title: X chromosome map at 75-kb STS resolution, revealing extremes of recombination and GC content.
abstract: A YAC/STS map of the X chromosome has reached an inter-STS resolution of 75 kb. The map density is sufficient to provide YACs or other large-insert clones that are cross-validated as sequencing substrates across the chromosome. Marker density also permits estimates of regional gene content and a detailed comparison of genetic and physical map distances. Five regions are detected with relatively high G + C, correlated with gene richness; and a 17-Mb region with very low recombination is revealed between the Xq13.3 [XIST] and Xq21.3 XY homology loci.
authors.affiliation: Center for Genetics in Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
authors.forename: R
authors.initials: R
authors.lastname: Nagaraja
authors.forename: S
authors.initials: S
authors.lastname: MacMillan
authors.forename: J
authors.initials: J
authors.lastname: Kere
authors.forename: C
authors.initials: C
authors.lastname: Jones
authors.forename: S
authors.initials: S
authors.lastname: Griffin
authors.forename: M
authors.initials: M
authors.lastname: Schmatz
authors.forename: J
authors.initials: J
authors.lastname: Terrell
authors.forename: M
authors.initials: M
authors.lastname: Shomaker
authors.forename: C
authors.initials: C
authors.lastname: Jermak
authors.forename: C
authors.initials: C
authors.lastname: Hott
authors.forename: M
authors.initials: M
authors.lastname: Masisi
authors.forename: S
authors.initials: S
authors.lastname: Mumm
authors.forename: A
authors.initials: A
authors.lastname: Srivastava
authors.forename: G
authors.initials: G
authors.lastname: Pilia
authors.forename: T
authors.initials: T
authors.lastname: Featherstone
authors.forename: R
authors.initials: R
authors.lastname: Mazzarella
authors.forename: S
authors.initials: S
authors.lastname: Kesterson
authors.forename: B
authors.initials: B
authors.lastname: McCauley
authors.forename: B
authors.initials: B
authors.lastname: Railey
authors.forename: F
authors.initials: F
authors.lastname: Burough
authors.forename: V
authors.initials: V
authors.lastname: Nowotny
authors.forename: M
authors.initials: M
authors.lastname: D'Urso
authors.forename: D
authors.initials: D
authors.lastname: States
authors.forename: B
authors.initials: B
authors.lastname: Brownstein
authors.forename: D
authors.initials: D
authors.lastname: Schlessinger
mesh_terms: D001482:Base Composition / Q000235:genetics; D002874:Chromosome Mapping / Q000379:methods; D018244:Chromosomes, Artificial, Yeast / Q000235:genetics; D003597:Cytosine Nucleotides / Q000235:genetics; D018076:DNA, Complementary / Q000235:genetics; D015870:Gene Expression / Q000235:genetics; D015698:Genomic Library; D006150:Guanine Nucleotides / Q000235:genetics; D006801:Humans; D016324:Sequence Tagged Sites; D014960:X Chromosome / Q000235:genetics*
chemical_list: D003597:Cytosine Nucleotides; D018076:DNA, Complementary; D006150:Guanine Nucleotides