[Use of antihypoxants and antioxidants for pharmaco-correction of disorders of water metabolism in the liver and small intestine after vagotomy].
Bilateral subdiaphragmatic vagotomy in rats leads to hepatic and small intestinal water metabolic disorders appeared as higher levels of total water, longer spin-grid (T1) and spin-spin (T2) relaxation and impaired correlation between T1 and T2. The time course of changes in water metabolism in the liver is one-sided (maximum after 7 days) at the same time in the small intestine is two-sided (maximum after 7 and 30 days). The antihypoxant tomerzole and the antioxidant dibunol produce a partial normalizing effect on water metabolism in the studied viscera of the animals vagotomized (at day 30), the highest efficiency was demonstrated by dibunol whose pharmacological activity is the greatest in the small intestine.
Tsybulevskiĭ
A Iu
AIu
Dubovaia
T K
TK
Sergeev
A I
AI
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D007421:Intestine, Small / Q000187:drug effects* / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D010455:Peptides / Q000627:therapeutic use*; D051381:Rats; D014628:Vagotomy / Q000009:adverse effects*; D014883:Water-Electrolyte Imbalance / Q000188:drug therapy*
D000975:Antioxidants; D010455:Peptides; C053892:cytomedins
Primenenie antigipoksantov i antioksidantov dlia farmakokorrektsii narusheniĭ metabolizma vody v pecheni i tonkoĭ kishke posle vagotomii.