title: Sex differences in mutation rate in higher primates estimated from AMG intron sequences.
abstract: To study sex differences in mutation rate in primates, we sequenced the third introns of the AMGX and AMGY genes from humans, orangutans, and squirrel monkeys and estimated that the male-to-female ratio of mutation rate is alpha = 5.14 with the 95% confidence interval (2.42, 16.6). Combining this data set and the data sets from ZFX/ZFY and SMCX/SMCY introns, we obtained an estimate of alpha = 5.06 with the 95% confidence interval reduced to (3.24, 8.79). The alpha value is significantly higher in higher primates than in rodents.
authors.affiliation: Human Genetics Center, SPH, University of Texas, P.O. Box 20334, Houston, TX 77225, USA.
authors.forename: W
authors.initials: W
authors.lastname: Huang
authors.forename: B H
authors.initials: BH
authors.lastname: Chang
authors.forename: X
authors.initials: X
authors.lastname: Gu
authors.forename: D
authors.initials: D
authors.lastname: Hewett-Emmett
authors.forename: W
authors.initials: W
authors.lastname: Li
mesh_terms: D000818:Animals; D016001:Confidence Intervals; D005260:Female; D006801:Humans; D007438:Introns; D008099:Liver / Q000378:metabolism; D008297:Male; D008957:Models, Genetic; D009154:Mutation; D010215:Papio / Q000235:genetics; D011148:Pongo pygmaeus / Q000235:genetics; D011323:Primates / Q000235:genetics*; D012377:Rodentia; D012453:Saimiri / Q000235:genetics; D012727:Sex Characteristics; D013045:Species Specificity; D013995:Time; D014960:X Chromosome; D014998:Y Chromosome