Marrow stromal cells as stem cells for nonhematopoietic tissues.
Marrow stromal cells can be isolated from other cells in marrow by their tendency to adhere to tissue culture plastic. The cells have many of the characteristics of stem cells for tissues that can roughly be defined as mesenchymal, because they can be differentiated in culture into osteoblasts, chondrocytes, adipocytes, and even myoblasts. Therefore, marrow stromal cells present an intriguing model for examining the differentiation of stem cells. Also, they have several characteristics that make them potentially useful for cell and gene therapy.
Prockop
D J
DJ
Center for Gene Therapy, Allegheny University of the Health Sciences, MCP-Hahnemann School of Medicine, 245 North 15 Street, Mail Stop 421, Philadelphia, PA 19102, USA. prockop@allegheny.edu
D017667:Adipocytes / Q000166:cytology; D000818:Animals; D001854:Bone Marrow Cells; D016026:Bone Marrow Transplantation; D002356:Cartilage / Q000166:cytology; D002454:Cell Differentiation; D002478:Cells, Cultured; D016207:Cytokines / Q000378:metabolism; D015316:Genetic Therapy; D006801:Humans; D018485:Muscle Fibers, Skeletal / Q000166:cytology; D010006:Osteoblasts / Q000166:cytology; D013234:Stem Cells / Q000166:cytology* / Q000502:physiology; D017154:Stromal Cells / Q000166:cytology* / Q000502:physiology
D016207:Cytokines