title: Conductance-based integrate-and-fire models.
abstract: A conductance-based model of Na+ and K+ currents underlying action potential generation is introduced by simplifying the quantitative model of Hodgkin and Huxley (HH). If the time course of rate constants can be approximated by a pulse, HH equations can be solved analytically. Pulse-based (PB) models generate action potentials very similar to the HH model but are computationally faster. Unlike the classical integrate-and-fire (IAF) approach, they take into account the changes of conductances during and after the spike, which have a determinant influence in shaping neuronal responses. Similarities and differences among PB, IAF, and HH models are illustrated for three cases: high-frequency repetitive firing, spike timing following random synaptic inputs, and network behavior in the presence of intrinsic currents.
authors.affiliation: Department of Physiology, Laval University School of Medicine, Québec, Canada.
authors.forename: A
authors.initials: A
authors.lastname: Destexhe
mesh_terms: D000200:Action Potentials / Q000502:physiology; D003198:Computer Simulation; D004594:Electrophysiology; D007473:Ion Channels / Q000502:physiology*; D008564:Membrane Potentials / Q000502:physiology; D016571:Neural Networks, Computer; D015221:Potassium Channels / Q000502:physiology; D015222:Sodium Channels / Q000502:physiology
chemical_list: D007473:Ion Channels; D015221:Potassium Channels; D015222:Sodium Channels