title: Timing, magnitude, and utility of surgical delay in the TRAM flap: I. Animal studies.
abstract: Surgical delay is an effective technique, but the precise timing of the delay effect and the required extent of the delay procedure are uncertain. We endeavored to study flap survival as a function of the duration of the delay period in a rat transverse rectus abdominis myocutaneous (TRAM) flap model. Two specific delay procedures (limited and extensive) were utilized, and flap survival was assessed after delay periods of 3, 7, 10, 14, 21, and 30 days (n > or = 7, all groups). A delay of 7 days or greater resulted in statistically significant improvement in flap survival in all groups. The delay effect appeared to be maximal at 14 days, and in the extensive delay group, a 14-day delay resulted in statistically greater flap survival than a 7-day delay. Improvement in flap survival was greater when an extensive delay procedure was used. Although the model system has limitations, the rat TRAM flap appears to be a suitable model for the study of the delay phenomenon. Possible clinical correlations are addressed in part II.
authors.affiliation: Yale University School of Medicine, New Haven, Conn., USA.
authors.forename: R J
authors.initials: RJ
authors.lastname: Restifo
authors.forename: S S
authors.initials: SS
authors.lastname: Ahmed
authors.forename: J S
authors.initials: JS
authors.lastname: Isenberg
authors.forename: J G
authors.initials: JG
authors.lastname: Thomson
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D004195:Disease Models, Animal; D005500:Follow-Up Studies; D006085:Graft Survival; D009336:Necrosis; D051381:Rats; D017207:Rats, Sprague-Dawley; D017568:Rectus Abdominis / Q000473:pathology / Q000637:transplantation*; D016038:Skin Transplantation / Q000145:classification / Q000379:methods* / Q000473:pathology; D013524:Surgical Flaps / Q000145:classification / Q000379:methods* / Q000473:pathology; D013536:Suture Techniques; D013997:Time Factors