title: Doppler index perfusion in the detection of hepatic metastases secondary to gastric carcinoma.
abstract: BACKGROUND
  The early detection of liver metastases in patients with gastric carcinoma is important for determining the appropriate therapy; however conventional imaging techniques are limited for detecting "occult" liver metastases. Previous studies have shown that the measurement of the Doppler perfusion index (DPI)-ratio of hepatic arterial to total liver blood flow-can detect the presence of even small hepatic tumors. In this study, we compared the measurement of DPI with computed tomography (CT) for detecting gastric liver metastases.
  
  
  METHODS
  At presentation, 43 patients with gastric carcinoma underwent CT scanning of the liver and after 12 hours of fasting, DPI measurement was carried out using Doppler sonography.
  
  
  RESULTS
  Both techniques detected overt liver metastases in 9 of the 43 patients. Of the 34 remaining patients with an apparently disease-free liver on the basis of CT, laparotomy, or laparoscopy, 14 subsequently develop liver metastases over a follow-up period of 4 years, 13 of which had been predicted by DPI at the time of presentation.
  
  
  CONCLUSIONS
  The data suggest that the measurement of the DPI is more sensitive than a CT scan for detecting liver metastases secondary to gastric carcinoma.
authors.affiliation: Department of Radiology, Royal Infirmary, Glasgow, United Kingdom.
authors.forename: E
authors.initials: E
authors.lastname: Leen
authors.forename: J R
authors.initials: JR
authors.lastname: Anderson
authors.forename: J
authors.initials: J
authors.lastname: Robertson
authors.forename: P
authors.initials: P
authors.lastname: O'Gorman
authors.forename: T G
authors.initials: TG
authors.lastname: Cooke
authors.forename: C S
authors.initials: CS
authors.lastname: McArdle
mesh_terms: D000368:Aged; D016009:Chi-Square Distribution; D005500:Follow-Up Studies; D006801:Humans; D010535:Laparoscopy; D007813:Laparotomy; D008102:Liver Circulation; D008113:Liver Neoplasms / Q000175:diagnosis* / Q000401:mortality / Q000503:physiopathology / Q000556:secondary*; D008175:Lung Neoplasms / Q000556:secondary; D008875:Middle Aged; D012680:Sensitivity and Specificity; D013274:Stomach Neoplasms / Q000401:mortality / Q000473:pathology*; D015996:Survival Rate; D014057:Tomography, X-Ray Computed; D018615:Ultrasonography, Doppler, Color; D018616:Ultrasonography, Doppler, Duplex