title: DNA gyrase as a drug target.
abstract: DNA gyrase is a remarkable enzyme, catalysing the seemingly complex reaction of DNA supercoiling. As gyrase is essential in prokaryotes, it is a good target for antibacterial agents. These agents have diverse chemical structures and interact with gyrase in a variety of ways.
authors.affiliation: Dept of Biochemistry, University of Leicester, UK. ony@leicester.ac.uk
authors.forename: A
authors.initials: A
authors.lastname: Maxwell
mesh_terms: D003374:Coumarins / Q000494:pharmacology; D004250:DNA Topoisomerases, Type II / Q000737:chemistry; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005544:Forecasting; D015363:Quinolones / Q000494:pharmacology; D059005:Topoisomerase II Inhibitors
chemical_list: D003374:Coumarins; D004791:Enzyme Inhibitors; D015363:Quinolones; D059005:Topoisomerase II Inhibitors; D004250:DNA Topoisomerases, Type II