Hemorheology in cerebral ischemia.
In the acute phase of ischemic stroke blood viscosity has been raised due to impaired plasticity of the erythrocytes and high value of plasma viscosity. Leukocyte membrane elasticity disfunction has also affected cerebral microcirculation. Stroke patients with concomitant hypertension indicated lower fibrinogen molecules contribution to the inter-red cells connections than the group without this additional disease. Persistence of abnormal hemorheological parameters has been observed following cerebral ischemia with increased blood and plasma viscosity, reduced plasticity of erythrocytes, higher fibrinogen level and increased erythrocytes aggregation, which suggests their role as possible risk factors. The selective plasmapheresis application beneficially influenced cerebral blood flow in microcirculation by means of hermorheological disturbances correction.
Kowal
P
P
Department of Neurology, School of Medicine, Poznań.
D000208:Acute Disease; D001809:Blood Viscosity; D002545:Brain Ischemia / Q000097:blood* / Q000628:therapy; D002561:Cerebrovascular Disorders / Q000097:blood* / Q000628:therapy; D004903:Erythrocyte Aggregation; D004907:Erythrocyte Deformability; D005340:Fibrinogen / Q000032:analysis; D018056:Hemorheology; D006801:Humans; D008875:Middle Aged; D010956:Plasmapheresis
D005340:Fibrinogen