Threshold-distance measures from electrical stimulation of human brainstem.
Threshold current levels for electrical stimulation of a single human brainstem via an auditory prosthesis are compared with postmortem measures of the distance between the electrode and stimulated structures. The results compare well with the summary of threshold-distance measures from animal experiments compiled by Ranck. The correspondence between the human and animal data gives confidence that the extent of current spread (distance to stimulable neural units) can be well estimated from the current level at threshold for 200 microseconds/phase biphasic pulses. This is of particular interest in electrical stimulation of the human central nervous system, where localization of stimulation is of paramount importance.
Shannon
R V
RV
House Ear Institute, Los Angeles, CA 90057, USA.
Moore
J K
JK
McCreery
D B
DB
Portillo
F
F
D000818:Animals; D001309:Auditory Threshold; D001933:Brain Stem / Q000502:physiology*; D003054:Cochlear Implants; D003638:Deafness / Q000209:etiology / Q000628:therapy*; D004599:Electric Stimulation Therapy; D004567:Electrodes, Implanted; D005260:Female; D006801:Humans; D016518:Neurofibromatosis 2 / Q000601:surgery; D011180:Postmortem Changes; D011571:Psychoacoustics; D013067:Speech Perception