Three new cryptophycins from Nostoc sp. GSV 224.
Cryptophycin 46 (2), -175 (3), and -176(4) have been identified as three new trace constituents of Nostoc sp. GSV 224. Cryptophycin-46 is an epimer of cryptophycin-3 (5) and to date is the only naturally occurring analogue having the S configuration at C-10 (C-2 in Unit B). Cryptophycins-175 and -176 also differ in unit B where 3 is the O-methyl analogue of cryptophycin-45 (6) and 4 is the O-desmethyl analogue of cryptophycin-21 (8). The relative and absolute stereochemistries of the three new analogues have been related to known cryptophycins by synthesis.
Subbaraju
G V
GV
Department of Chemistry, University of Hawaii, Honolulu 96822, USA.
Golakoti
T
T
Patterson
G M
GM
Moore
R E
RE
D002851:Chromatography, High Pressure Liquid; D000458:Cyanobacteria / Q000737:chemistry*; D047630:Depsipeptides; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007624:KB Cells; D007769:Lactams / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D007783:Lactones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D014407:Tumor Cells, Cultured
D047630:Depsipeptides; D007769:Lactams; D007783:Lactones; C105639:cryptophycin 175; C105640:cryptophycin 176; C105638:cryptophycin 46