title: [Complications of nasal CPAP therapy. Consequences for general practice].
abstract: BACKGROUND
  The prevalence of the obstructive sleep apnea syndrome is about 5% in the entire population. The amount of treatment-indications grows for this particular sleep-related breathing disorder due to the increasing usage of diagnostic screening tests. In most cases, the positive-pressure ventilation, PPV (nCPAP, nBiPAP) is considered as a highly effective form of treatment, in comparison to other treating methods. The residential polysomnographic supervised adjustment of the treatment is optimally applied to most of the patients. Due to the increasing number of the treated patients, the reports about the appearance of short-termed side effects during the adjustment of the PPV become more frequent.
  
  
  RESULTS
  We report on 9 patients who showed complications during the initial stage of treatment. The most common one, during the nCPAP-therapy, was the increase of central apneas. Because of this complication, a rapid optimization of the respiratory pressure or a change to a nBiPAP-therapy was necessary in 5 of the patients. 2 of the patients showed cardiac arrhythmias, some of which were severe. One patient produced a remarkable central hypoventilation during the initial phase of a nCPAP-therapy. The nBiPAP-titration combined with right-heart-catheter monitoring could demonstrate in another patient a possible cardiac decompensation through an increased ventilatory pressure.
  
  
  CONCLUSIONS
  The risk of a positive-pressure ventilation is higher in patients with accompanying cardiac, pulmonary, neuropsychiatric and/or otorhinolaryngologic disorders. Considering the various predisposing factors of the patients we suggest an intensive apparative monitoring as well as stuff-supervision during the introduction to a respiratory treatment. If complications appear, a rapid improvement of the ventilatory pressure or a change to another respiratory treatment is indicated.
authors.affiliation: Medizinische Klinik I. Schlafmedizinisches Zentrum, Charité, Berlin.
authors.forename: I
authors.initials: I
authors.lastname: Fietze
authors.forename: P L
authors.initials: PL
authors.lastname: Bölcskei
authors.forename: K
authors.initials: K
authors.lastname: Hörmann
authors.forename: R
authors.initials: R
authors.lastname: Lund
authors.forename: G
authors.initials: G
authors.lastname: Mayer
authors.forename: D
authors.initials: D
authors.lastname: Müller
authors.forename: J H
authors.initials: JH
authors.lastname: Peter
authors.forename: K
authors.initials: K
authors.lastname: Rasche
authors.forename: K H
authors.initials: KH
authors.lastname: Rühle
authors.forename: B
authors.initials: B
authors.lastname: Sanner
authors.forename: R
authors.initials: R
authors.lastname: Schmatzler
authors.forename: A
authors.initials: A
authors.lastname: Stammnitz
authors.forename: M E
authors.initials: ME
authors.lastname: Schläfke
mesh_terms: D000368:Aged; D002318:Cardiovascular Diseases / Q000150:complications* / Q000175:diagnosis; D015716:Electrocardiography, Ambulatory; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017286:Polysomnography; D011175:Positive-Pressure Respiration / Q000009:adverse effects* / Q000295:instrumentation; D012307:Risk Factors; D012891:Sleep Apnea Syndromes / Q000628:therapy*; D016896:Treatment Outcome
vernacular_title: Komplikationen bei der nasalen CPAP-Therapie. Konsequenzen für die Praxis.