title: Low-frequency ultradian insulin rhythms are coupled to cardiovascular, autonomic, and neuroendocrine rhythms.
abstract: Plasma insulin levels were assayed to compare with earlier reported rhythms of the cardiovascular, autonomic, and neuroendocrine systems in 10 resting normal adults over 5-6 h. Our earlier report included time-series analysis for impedance cardiography measures of stroke volume, heart rate, cardiac output, thoracic fluid index, ejection velocity index, and ventricular ejection time; automated cuff measures of systolic, diastolic, and mean arterial pressures; the nasal cycle as a marker of lateralized autonomic tone; and indwelling venous catheters for sampling blood every 7.5 min to assay for adrenocorticotropic hormone, luteinizing hormone, epinephrine, and norepinephrine. Insulin was later assayed from the same plasma samples. Time-series analysis using the fast orthogonal search method of Korenberg detected insulin periodicities at ranges of 220-340, 115-145, 70-100, and 40-65, with significance across subjects at ranges of 115-145, 70-100, and 40-65 min. Significant periods for the other parameters were reported earlier at 220-340, 170-215, 115-145, 70-100, and 40-65 min, with periods at 115-145, 70-100, and 40-65 min dominating across parameters. These results suggest that insulin secretion has a common pacemaker (the hypothalamus) or a mutually entrained pacemaker with the autonomic, cardiovascular, and neuroendocrine systems.
authors.affiliation: Institute for Nonlinear Science, University of California, San Diego, La Jolla 92093-0402, USA.
authors.forename: D S
authors.initials: DS
authors.lastname: Shannahoff-Khalsa
authors.forename: B
authors.initials: B
authors.lastname: Kennedy
authors.forename: F E
authors.initials: FE
authors.lastname: Yates
authors.forename: M G
authors.initials: MG
authors.lastname: Ziegler
mesh_terms: D000204:Activity Cycles; D000324:Adrenocorticotropic Hormone / Q000097:blood / Q000378:metabolism; D000328:Adult; D001341:Autonomic Nervous System / Q000502:physiology*; D001683:Biological Clocks; D001794:Blood Pressure; D002302:Cardiac Output; D003971:Diastole; D004837:Epinephrine / Q000097:blood / Q000378:metabolism; D005260:Female; D006339:Heart Rate; D006439:Hemodynamics; D006728:Hormones / Q000097:blood / Q000378:metabolism*; D006801:Humans; D007031:Hypothalamus / Q000502:physiology; D007328:Insulin / Q000097:blood / Q000378:metabolism*; D000078790:Insulin Secretion; D007986:Luteinizing Hormone / Q000097:blood / Q000378:metabolism; D008297:Male; D009638:Norepinephrine / Q000097:blood / Q000378:metabolism; D009666:Nose; D012016:Reference Values; D013318:Stroke Volume; D013599:Systole; D014655:Vascular Resistance
chemical_list: D006728:Hormones; D007328:Insulin; D000324:Adrenocorticotropic Hormone; D007986:Luteinizing Hormone; D009638:Norepinephrine; D004837:Epinephrine