Relationship between interleukin-8 levels and myeloperoxidase activity in human gastric mucosa.
Although interleukin (IL)-8 is well known as a chemotactic agent for neutrophil migration in vitro, the relationship between IL-8 activity and the degree of neutrophil infiltration in gastric mucosa is still unclear. In the present study, we investigated IL-8 and myeloperoxidase activity, a marker of neutrophil infiltration, in gastric antral mucosa using biopsy samples in 23 patients with no gastric lesions. The results indicate that there is a good correlation between IL-8 and myeloperoxidase activity (y = 0.173x + 13.9; r = 0.49, P < 0.01). Furthermore, IL-8 and myeloperoxidase activity are significantly higher in Helicobacter pylori-positive patients than in H. pylori-negative patients. In conclusion, an increase of IL-8 activity in the gastric mucosa causes increased neutrophil infiltration in human gastric mucosa and H. pylori infection accelerates these reactions in the mucosa.
Sasayama
Y
Y
Department of Medicine, Osaka University School of Medicine, Suita, Japan.
Kawano
S
S
Tsuji
S
S
Fusamoto
H
H
Kamada
T
T
Fukui
H
H
Yoneda
S
S
Okishio
T
T
D000368:Aged; D002167:Campylobacter / Q000302:isolation & purification; D005260:Female; D005753:Gastric Mucosa / Q000201:enzymology* / Q000382:microbiology; D016480:Helicobacter pylori / Q000302:isolation & purification; D006801:Humans; D016209:Interleukin-8 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009195:Peroxidase / Q000378:metabolism*
D016209:Interleukin-8; D009195:Peroxidase