title: [Dynamics of the haplotype frequencies in populations: study using the Monte Carlo method].
abstract: A program that simulates random genetic drift, random mating, recombination, natural selection, and mutation process was developed to study the influence of these processes on the evolutionary dynamics of haplotype frequencies in populations. The program can track nine sites, each including up to 15 alleles. The program application was illustrated by the study of frequency dynamics in the HOXB haplotypes (17q) in different populations. The simulation results confirmed the hypothesis, which was proposed on the basis of the experimental data, that, in the absence of recurrent mutations, population mixing, and natural selection, the harmonic mean of the effective population size from the moment of New World colonization up to now was more than 1000.
authors.affiliation: Yale University, Department of Genetics, New Haven 06520, USA.
authors.forename: E L
authors.initials: EL
authors.lastname: Grigorenko
authors.forename: A A
authors.initials: AA
authors.lastname: Shikanian
authors.forename: D R
authors.initials: DR
authors.lastname: Kidd
authors.forename: R
authors.initials: R
authors.lastname: Dorig
authors.forename: K K
authors.initials: KK
authors.lastname: Kidd
mesh_terms: D000483:Alleles; D002874:Chromosome Mapping; D003198:Computer Simulation; D005787:Gene Frequency; D006239:Haplotypes; D006801:Humans; D008957:Models, Genetic; D009010:Monte Carlo Method; D011995:Recombination, Genetic; D012641:Selection, Genetic; D012984:Software
vernacular_title: Dinamika chastot gaplotipov v populiatsiiakh: issledovanie metodom Monte Karlo.