title: Accuracy of asthma treatment in schoolchildren in NSW, Australia.
abstract: Insufficient use of anti-inflammatory drugs, such as inhaled corticosteroids and cromoglycate, may contribute to the disease burden associated with asthma. Conversely, aggressive treatment of mild disease may result in avoidable costs and/or adverse drug effects. The aim of this study was to determine the relationship between asthma severity and inhaled corticosteroid/cromoglycate use in a large (n=4,909) random sample of children, aged 8-11 yrs, in NSW, Australia. Asthma and its treatment were assessed by questionnaire responses. Asthma, defined as diagnosis plus current wheeze, was present in 901 children (18% of the sample), of whom 225 (5%) had moderate asthma, defined as asthma plus additional symptoms (sleep disturbance), utilization (hospital, casualty), or disability (reduced activity, school absence). Use of inhaled corticosteroid/cromoglycate was reported by 636 children (13% of the sample). Determinants of use included: asthma diagnosis, current wheeze, and troublesome dry nocturnal cough. There was also a strong relationship between anti-inflammatory treatment and a multicomponent asthma severity score constructed for each child. Inhaled corticosteroids and/or cromoglycate were used by 56% of the children with asthma (24% daily) and by 76% of children with moderate asthma (42% daily). Undertreatment, defined as less than daily inhaled corticosteroids/cromoglycate in moderate asthma, was identified in 130 children (14% of those with asthma or 3% of the sample). Conversely, apparently aggressive treatment, defined as inhaled corticosteroid/cromoglycate use in children with persistent minimal symptoms (asthma severity score of less than 3) was identified in 101 children (2% of the sample). Although there were significant differences between regions in the choice of anti-inflammatory drugs and in the prevalence both of undertreatment and apparently aggressive treatment, there was no clear relationship to regional utilization of emergency and hospital services for asthma. Nevertheless, the frequency of undertreatment suggests an opportunity to reduce asthma morbidity by more consistent application of current therapeutic guidelines.
authors.affiliation: Dept of Medicine, University of Western Ontario, London, Canada.
authors.forename: N A
authors.initials: NA
authors.lastname: Paterson
authors.forename: J K
authors.initials: JK
authors.lastname: Peat
authors.forename: C M
authors.initials: CM
authors.lastname: Mellis
authors.forename: W
authors.initials: W
authors.lastname: Xuan
authors.forename: A J
authors.initials: AJ
authors.lastname: Woolcock
mesh_terms: D000280:Administration, Inhalation; D018927:Anti-Asthmatic Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D001249:Asthma / Q000175:diagnosis / Q000188:drug therapy* / Q000453:epidemiology; D016022:Case-Control Studies; D002648:Child; D004205:Cromolyn Sodium / Q000008:administration & dosage* / Q000627:therapeutic use; D004363:Drug Utilization; D006801:Humans; D009517:New South Wales / Q000453:epidemiology; D010818:Practice Patterns, Physicians'; D015995:Prevalence; D012494:Sampling Studies; D012720:Severity of Illness Index; D013256:Steroids; D011795:Surveys and Questionnaires
chemical_list: D018927:Anti-Asthmatic Agents; D000893:Anti-Inflammatory Agents; D013256:Steroids; D004205:Cromolyn Sodium