title: Arteriovenous malformation of the vein of Galen in three neonates: emphasis on associated early ischaemic brain damage.
abstract: Vein of Galen malformation is a rare intracranial disorder in newborns. In recent years the survival rate has improved due to improvement in endovascular treatment of this abnormality. We describe three neonates with a vein of Galen malformation for whom treatment was not attempted because of associated severe cerebral damage, of antenatal origin in two and of perinatal origin in the other. Autopsy was performed in two neonates. Periventricular leukomalacia was present in both cases, associated in one case with cortical infarction, gliosis and atrophy.
  
  
  CONCLUSIONS
  We recommend careful evaluation of associated cerebral damage prior to attempted treatment of the vein of Galen malformation.
authors.affiliation: Department of Neonatology, Wilhelmina Children's Hospital, Utrecht, The Netherlands.
authors.forename: T J
authors.initials: TJ
authors.lastname: de Koning
authors.forename: R
authors.initials: R
authors.lastname: Gooskens
authors.forename: R
authors.initials: R
authors.lastname: Veenhoven
authors.forename: E J
authors.initials: EJ
authors.lastname: Meijboom
authors.forename: G H
authors.initials: GH
authors.lastname: Jansen
authors.forename: P
authors.initials: P
authors.lastname: Lasjaunias
authors.forename: L S
authors.initials: LS
authors.lastname: de Vries
mesh_terms: D001284:Atrophy; D001921:Brain / Q000473:pathology; D001925:Brain Damage, Chronic / Q000151:congenital* / Q000175:diagnosis; D002545:Brain Ischemia / Q000151:congenital* / Q000175:diagnosis; D002550:Cerebral Veins / Q000002:abnormalities* / Q000473:pathology; D004453:Echoencephalography; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D002538:Intracranial Arteriovenous Malformations / Q000175:diagnosis*; D007969:Leukomalacia, Periventricular / Q000175:diagnosis; D008297:Male; D014057:Tomography, X-Ray Computed