title: [Drug-induced rhabdomyolysis and lesions of peripheral nerves. Sequelae of local ischemia within the scope of circulatory collapse?].
abstract: We report on two patients with severe rhabdomyolysis and peripheral nerve involvement after drug intoxication. Nerve conduction studies of the paretic extremities of both patients could be performed within 12 h of the onset. Several nerves revealed evidence of conduction blocks in the paretic extremities. One of the patients who had taken heroin died and postmortem examination was performed. A drug-induced immune vasculitis could not be demonstrated. Besides striated muscle necrosis, extensive myocardial fragmentation was shown. Territorial ischemia, resulting from systemic hypotension and mechanical compression of arteries, seems to have been the cause of the myonecroses and peripheral nerve damage in the unconscious patients.
authors.affiliation: Neurologische Klinik, Ruhr-Universität, Bochum.
authors.forename: G
authors.initials: G
authors.lastname: Amoiridis
authors.forename: L
authors.initials: L
authors.lastname: Schöls
authors.forename: D
authors.initials: D
authors.lastname: Pöhlau
authors.forename: K
authors.initials: K
authors.lastname: Berger
authors.forename: W
authors.initials: W
authors.lastname: Niemczyk
authors.forename: H
authors.initials: H
authors.lastname: Przuntek
mesh_terms: D000293:Adolescent; D000328:Adult; D002186:Cannabinoids / Q000009:adverse effects; D000431:Ethanol / Q000009:adverse effects; D017809:Fatal Outcome; D005260:Female; D005445:Flunitrazepam / Q000009:adverse effects; D006323:Heart Arrest / Q000139:chemically induced* / Q000175:diagnosis / Q000473:pathology; D003932:Heroin / Q000009:adverse effects; D006801:Humans; D013287:Illicit Drugs / Q000009:adverse effects*; D007511:Ischemia / Q000139:chemically induced* / Q000175:diagnosis / Q000473:pathology; D007866:Leg / Q000294:innervation; D008297:Male; D018482:Muscle, Skeletal / Q000294:innervation; D009460:Neurologic Examination / Q000187:drug effects; D010525:Peripheral Nerves / Q000098:blood supply* / Q000473:pathology; D011619:Psychotropic Drugs / Q000009:adverse effects*; D012206:Rhabdomyolysis / Q000139:chemically induced* / Q000175:diagnosis / Q000473:pathology; D019966:Substance-Related Disorders / Q000150:complications*; D009435:Synaptic Transmission / Q000187:drug effects
chemical_list: D002186:Cannabinoids; D013287:Illicit Drugs; D011619:Psychotropic Drugs; D000431:Ethanol; D005445:Flunitrazepam; D003932:Heroin
vernacular_title: Drogeninduzierte Rhabdomyolyse und Läsionen peripherer Nervenstränge. Folge einer territorialen Ischämie im Rahmen eines Kreislaufkollapses?