[Antioxidants in the treatment of schizophrenia (the correction of lipid peroxidation processes)].
It was established in the course of 185 schizophrenic patients' examination that intensification of lipid peroxidation (LP) took place in relapses of the disease. It was manifested either in increase of blood serum levels of both malonic dialdehyde and diene conjugates, or in decrease of erythrocytes' resistance to LP mediated hemolysis. Alterations in indices of either spontaneous or induced chemoluminescence were revealed too. LP indices were lower by the end of the treatment in hospital, but remained significantly higher than normal values. Application of antioxidants in combined treatment of schizophrenic patients promoted decrease of LP activity as well as improvement in mental state of patients. LP activity was high in the remission too. Determination of LP indices may have prognostic importance.
Kut'ko
I I
II
Frolov
V M
VM
Pustovoĭ
Iu G
IuG
Rachkauskas
G S
GS
Pavlenko
V V
VV
D000328:Adult; D000975:Antioxidants / Q000627:therapeutic use*; D014150:Antipsychotic Agents / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D005609:Free Radicals / Q000097:blood; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects*; D008054:Lipid Peroxides / Q000097:blood; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D012008:Recurrence; D012559:Schizophrenia / Q000097:blood / Q000188:drug therapy*
D000975:Antioxidants; D014150:Antipsychotic Agents; D005609:Free Radicals; D008054:Lipid Peroxides; D008315:Malondialdehyde
Antioksidanty v lechenii shizofrenii (korrektsiia protsessov perekisnogo okisleniia lipidov).