title: Lifetime co-occurrence of DSM-III-R alcohol abuse and dependence with other psychiatric disorders in the National Comorbidity Survey.
abstract: OBJECTIVE
  To study patterns of co-occurrence of lifetime DSM-III-R alcohol disorders in a household sample.
  
  
  METHODS
  Data came from the National Comorbidity Survey (NCS), a nationally representative household survey. Diagnoses were based on a modified version of the Composite International Diagnostic Interview.
  
  
  RESULTS
  Respondents with lifetime NCS/DSM-III-R alcohol abuse or dependence had a high probability of carrying at least 1 other lifetime NCS/DSM-III-R diagnosis. Retrospective reports have suggested that most lifetime co-occurring alcohol disorders begin at a later age than at least 1 other NCS/DSM-III-R disorder. Earlier disorders are generally stronger predictors of alcohol dependence than alcohol abuse and stronger among women than men. Lifetime co-occurrence is positively, but weakly, associated with the persistence of alcohol abuse among men and of alcohol dependence among both men and women.
  
  
  CONCLUSIONS
  Caution is needed in interpreting the results due to the fact that diagnoses were made by nonclinicians and results are based on retrospective reports of the age at onset. Within the context of these limitations, though, these results show that alcohol abuse and dependence are often associated with other lifetime DSM-III-R disorders and suggest that, at least in recent cohorts, the alcohol use disorders are usually temporally secondary. Prospective data and data based on clinically confirmed diagnoses are needed to verify these findings.
authors.affiliation: Department of Health Care Policy, Harvard Medical School, Boston, Mass, USA.
authors.forename: R C
authors.initials: RC
authors.lastname: Kessler
authors.forename: R M
authors.initials: RM
authors.lastname: Crum
authors.forename: L A
authors.initials: LA
authors.lastname: Warner
authors.forename: C B
authors.initials: CB
authors.lastname: Nelson
authors.forename: J
authors.initials: J
authors.lastname: Schulenberg
authors.forename: J C
authors.initials: JC
authors.lastname: Anthony
mesh_terms: D017668:Age of Onset; D000437:Alcoholism / Q000453:epidemiology*; D015897:Comorbidity; D005260:Female; D006306:Health Surveys; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000453:epidemiology*; D015995:Prevalence; D011336:Probability; D012189:Retrospective Studies; D012737:Sex Factors; D014481:United States / Q000453:epidemiology