title: In vitro activity of a new semisynthetic echinocandin, LY-303366, against systemic isolates of Candida species, Cryptococcus neoformans, Blastomyces dermatitidis, and Aspergillus species.
abstract: The in vitro activities of LY-303366, a new semisynthetic echinocandin, and comparators amphotericin B, 5-fluorocytosine, fluconazole, and ketoconazole against 205 systemic isolates of Candida species, Cryptococcus neoformans, Blastomyces dermatitidis, and Aspergillus species were determined. LY-303366 had MICs of < or = 0.32 microg/ml for all Candida albicans (n = 99), Candida glabrata (n = 18), and Candida tropicalis (n = 10) isolates tested. LY-303366 was also active against Aspergillus species (minimum effective concentration at which 90% of the isolates are inhibited, 0.02 microg/ml) (n = 20), was less active against Candida parapsilosis (MIC at which 90% of the isolates are inhibited [MIC90], 5.12 microg/ml) (n = 10), and was inactive against C. neoformans (MIC90, >10.24 microg/ml) (n = 15) and B. dermatitidis (MIC90, 16 microg/ml) (n = 29).
authors.affiliation: Department of Medical Microbiology and Faculty of Pharmacy, University of Manitoba, Winnipeg, Canada. ggzhanel@pcs.mb.ca
authors.forename: G G
authors.initials: GG
authors.lastname: Zhanel
authors.forename: J A
authors.initials: JA
authors.lastname: Karlowsky
authors.forename: G A
authors.initials: GA
authors.lastname: Harding
authors.forename: T V
authors.initials: TV
authors.lastname: Balko
authors.forename: S A
authors.initials: SA
authors.lastname: Zelenitsky
authors.forename: M
authors.initials: M
authors.lastname: Friesen
authors.forename: A
authors.initials: A
authors.lastname: Kabani
authors.forename: M
authors.initials: M
authors.lastname: Turik
authors.forename: D J
authors.initials: DJ
authors.lastname: Hoban
mesh_terms: D000077612:Anidulafungin; D000935:Antifungal Agents / Q000494:pharmacology*; D001230:Aspergillus / Q000187:drug effects; D001758:Blastomyces / Q000187:drug effects; D002175:Candida / Q000187:drug effects; D003455:Cryptococcus neoformans / Q000187:drug effects; D054714:Echinocandins; D005658:Fungi / Q000187:drug effects*; D006801:Humans; D008826:Microbial Sensitivity Tests; D009181:Mycoses / Q000382:microbiology; D010456:Peptides, Cyclic / Q000494:pharmacology*
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D010456:Peptides, Cyclic; D000077612:Anidulafungin