Combination therapy in Kala-azar.
128 untreated cases of Kala-azar were divided in 4 equal groups of 32, Group A was treated with Sodium Stibogluconate (SSG) in the dose of 20 mg/kg/body wt. for 30 days. Group B was treated SSG plus allopurinol in the dose of 20 mg/kg/body wt. orally in divided dosage for 30 days. Group C received SSG plus Ketoconazole 600 mg orally in divided dosage for 30 days. Group D in addition to SSG also received levamisole in single oral daily dose of 13 mg/kg/body wt. for 30 days. Response of Group B, C and D was compared to Group A. Results from this study revealed combination of allopurinol with SSG to be statistically not superior to SSG alone.
Singh
N K
NK
Kala-azar Research Centre, Barhmpura, Muzaffarpur.
Jha
T K
TK
Singh
I J
IJ
Jha
S
S
D000328:Adult; D000493:Allopurinol / Q000009:adverse effects / Q000627:therapeutic use; D000967:Antimony Sodium Gluconate / Q000009:adverse effects / Q000627:therapeutic use; D000981:Antiprotozoal Agents / Q000009:adverse effects / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007654:Ketoconazole / Q000009:adverse effects / Q000627:therapeutic use; D007898:Leishmaniasis, Visceral / Q000188:drug therapy*; D007978:Levamisole / Q000009:adverse effects / Q000627:therapeutic use; D008297:Male
D000981:Antiprotozoal Agents; D007978:Levamisole; D000493:Allopurinol; D007654:Ketoconazole; D000967:Antimony Sodium Gluconate