[Effect of lactin and thyroidin on systemic hemodynamics and oxygen regimen of the body in hemorrhagic shock].
The experiments on 28 unconscious male cats revealed the antishock effect of thyroidin (0.15 g/kg, intraperitoneally) through the positive myocardial inotropic effect, which, in addition to enhanced total peripheral vascular resistance, caused elevated blood pressure (BP). The antishock effect of thyroidin was substantially enhanced after a single intravenous injection of lactin (50 U/kg), as expressed by the recovery of plasma volumes, cardiac output at the expense of cardiac systolic volumes, and elevated BP. Thyroidin may be used only as an ingredient of combined antishock therapy as it induces intensive of oxidative process, as evidenced by higher utilization co-efficient for oxygen and its uptake at the baseline levels in shock, and by short-term elevations of blood temperatures.
Dzhurko
B I
BI
D000818:Animals; D002415:Cats; D006439:Hemodynamics / Q000187:drug effects*; D007785:Lactose / Q000627:therapeutic use*; D010100:Oxygen / Q000378:metabolism*; D012771:Shock, Hemorrhagic / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D013963:Thyroid Hormones / Q000627:therapeutic use*
D013963:Thyroid Hormones; C004227:thyroidin; D007785:Lactose; D010100:Oxygen
Vliianie laktina i tireoidina na sistemnuiu gemodinamiku i kislorodnyĭ rezhim organizma pri gemorragicheskom shoke.