title: Neuropathological studies on strains of senescence-accelerated mice (SAM) with age-related deficits in learning and memory.
abstract: In a series of inbred Senescence-Accelerated mice (SAM) strains, accelerated-senescence prone SAMP substrains show early onset and rapid advancement of senescence. SAMP8 and SAMP10, in particular, exhibit a significant age-related deterioration in memory and learning for passive and active avoidance tasks with, respectively, a low and high incidence of systemic senile amyloidosis. In the brains of both SAMP8 and SAMP10 strains, we have found numerous morphological alterations. Here we review the changes seen in both neuronal or glial components in SAMP8/P10 brains. They may serve as markers of the neuronal degeneration leading to the deficits in learning and memory.
authors.affiliation: Department of Neurology, Faculty of Medicine, Kyoto University, Japan. kawamata@hiabcd.go.jp
authors.forename: T
authors.initials: T
authors.lastname: Kawamata
authors.forename: I
authors.initials: I
authors.lastname: Akiguchi
authors.forename: H
authors.initials: H
authors.lastname: Yagi
authors.forename: M
authors.initials: M
authors.lastname: Irino
authors.forename: H
authors.initials: H
authors.lastname: Sugiyama
authors.forename: H
authors.initials: H
authors.lastname: Akiyama
authors.forename: A
authors.initials: A
authors.lastname: Shimada
authors.forename: M
authors.initials: M
authors.lastname: Takemura
authors.forename: M
authors.initials: M
authors.lastname: Ueno
authors.forename: T
authors.initials: T
authors.lastname: Kitabayashi
authors.forename: K
authors.initials: K
authors.lastname: Ohnishi
authors.forename: N
authors.initials: N
authors.lastname: Seriu
authors.forename: K
authors.initials: K
authors.lastname: Higuchi
authors.forename: M
authors.initials: M
authors.lastname: Hosokawa
authors.forename: T
authors.initials: T
authors.lastname: Takeda
mesh_terms: D000375:Aging / Q000235:genetics / Q000473:pathology* / Q000523:psychology; D000818:Animals; D007859:Learning Disabilities / Q000235:genetics / Q000473:pathology*; D008569:Memory Disorders / Q000235:genetics / Q000473:pathology*; D051379:Mice; D008815:Mice, Inbred Strains; D019150:Neuroaxonal Dystrophies / Q000473:pathology; D009474:Neurons / Q000473:pathology; D010641:Phenotype; D013997:Time Factors