Adjunctive subconjunctival mitomycin C in glaucoma triple procedure.
OBJECTIVE
To evaluate the potential benefit of adjunctive subconjunctival mitomycin in patients with primary open-angle glaucoma undergoing primary trabeculectomy combined with phacoemulsification and intraocular lens implantation.


METHODS
Seventy-eight eyes of 78 patients with primary open-angle glaucoma with visually symptomatic cataracts and no previous incisional surgery were randomized to receive either no mitomycin C or a subconjunctival application of 1-, 3-, or 5-minute mitomycin C (0.5 mg/ml).


RESULTS
Follow-up (mean +/- standard deviation) was 21.0 +/- 7.7 months. The mean postoperative intraocular pressures were significantly lower with significantly less medications than the preoperative values at each follow-up time (1, 3, 6, 9, 12, 15 months, and last follow-up) for all groups (P < 0.05 for each). However, there was no significant difference at each follow-up time in intraocular pressure, medications, or best-corrected visual acuity among the four groups or between the control and the total mitomycin C group.


CONCLUSIONS
Adjunctive subconjunctival mitomycin C did not further improve the final intraocular pressure outcome of the primary trabeculectomy combined with phacoemulsification and intraocular lens implantation in patients with primary open-angle glaucoma. Future studies will determine the appropriate role, if any, for adjunctive mitomycin C in selected primary glaucoma triple procedures.
Shin
D H
DH
Kresge Eye Institute, Wayne State University School of Medicine, Detroit, MI 48201-1423, USA.
Simone
P A
PA
Song
M S
MS
Reed
S Y
SY
Juzych
M S
MS
Kim
C
C
Hughes
B A
BA
D000368:Aged; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage*; D002386:Cataract / Q000150:complications; D017024:Chemotherapy, Adjuvant; D003228:Conjunctiva; D005260:Female; D005500:Follow-Up Studies; D005902:Glaucoma, Open-Angle / Q000150:complications / Q000188:drug therapy / Q000601:surgery*; D006801:Humans; D007429:Intraocular Pressure; D007910:Lenses, Intraocular; D008297:Male; D016685:Mitomycin / Q000008:administration & dosage*; D018918:Phacoemulsification; D011446:Prospective Studies; D014130:Trabeculectomy; D014792:Visual Acuity
D000903:Antibiotics, Antineoplastic; D016685:Mitomycin