[New chemical method for synthesis of O-linked glycopeptides].
The diphenylketone Shiff-base appeared to be a very good protection from amino groups of serine and threonine for glycosylation reaction. O-Glycosides of these amino acids with different monosaccharides, aminosugars and deoxysugars were obtained with excellent yield and very high stereoselectivity. Products of glycosylation reactions were used as building blocks for solid phase glycopeptide synthesis.
Polt
R L
RL
Department of Chemistry, University of Arizona, Tucson, USA.
Szabo
L
L
Ramza
J
J
D006020:Glycopeptides / Q000138:chemical synthesis*; D006031:Glycosylation
D006020:Glycopeptides
Nowa chemiczna metoda syntezy O-połaczonych glikopeptydów.