Gastric mucosal injury by nonsteroidal anti-inflammatory drugs is reduced by (R)-alpha-methylhistamine and its pro-drugs in the rat.
Morini
G
G
Institute of Pharmacology, University of Parma, Italy.
Grandi
D
D
Krause
M
M
Schunack
W
W
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D001241:Aspirin / Q000009:adverse effects; D005744:Gastric Acid / Q000378:metabolism; D005753:Gastric Mucosa / Q000187:drug effects*; D017442:Histamine Agonists / Q000627:therapeutic use*; D007213:Indomethacin / Q000009:adverse effects; D008297:Male; D008761:Methylhistamines / Q000627:therapeutic use*; D011355:Prodrugs / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D013276:Stomach Ulcer / Q000139:chemically induced* / Q000517:prevention & control*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D017442:Histamine Agonists; D008761:Methylhistamines; D011355:Prodrugs; C069357:alpha-methylhistamine; D001241:Aspirin; D007213:Indomethacin