The challenge posed by endocrine-disrupting chemicals.
Rapid regulatory developments in the area of environmental endocrine disruption present a series of potential problems that are identified and illustrated with examples taken from the recent literature. A list of priorities is provided, including the need for additional epidemiological and wildlife studies, the derivation of a coordinated testing strategy, agreement on the toxicities expected of endocrine disrupting agents, and acceptance that whole animal assays will be uniquely critical in this area of toxicology. The intrinsic difficulty of attempting to simultaneously study all aspects of endocrine disruption indicates the need to reduce the scope of the problem, which can be achieved by first studying toxicities mediated by sex hormone receptors.
Ashby
J
J
Zeneca, Macclesfield, Cheshire, United Kingdom.
Houthoff
E
E
Kennedy
S J
SJ
Stevens
J
J
Bars
R
R
Jekat
F W
FW
Campbell
P
P
Van Miller
J
J
Carpanini
F M
FM
Randall
G L
GL
D059002:Androgen Receptor Antagonists; D000818:Animals; D001943:Breast Neoplasms / Q000139:chemically induced; D002273:Carcinogens / Q000009:adverse effects* / Q000592:standards / Q000633:toxicity; D004785:Environmental Pollutants / Q000009:adverse effects* / Q000633:toxicity; D005260:Female; D006801:Humans; D008297:Male; D051379:Mice; D051381:Rats; D011960:Receptors, Estrogen / Q000819:agonists*; D013094:Spermatozoa / Q000187:drug effects; D013329:Structure-Activity Relationship; D018675:Toxicity Tests / Q000592:standards
D059002:Androgen Receptor Antagonists; D002273:Carcinogens; D004785:Environmental Pollutants; D011960:Receptors, Estrogen