Relationship between HLA-C locus and restenosis after coronary artery balloon angioplasty.
OBJECTIVE
To determine the relationship between human leukocyte antigen (HLA) loci and restenosis after percutaneous transluminal coronary angioplasty (PTCA).


METHODS
Cross-sectional study in patients treated by PTCA at Juntendo University Hospital, Tokyo, Japan.


METHODS
A total of 65 patients (58 males and 7 females) with coronary artery stenosis who were consecutively selected between October 1994 and June 1995.


METHODS
Significant relationships between the restenosis and the HLA-Cw1.


RESULTS
Among HLA-C locus, Cw1 was negatively related to restenosis (multivariate adjusted odds ratio, 0.19; 95% confidence interval, 0.06-0.63; P=.007).


CONCLUSIONS
In HLA typing, Cw1 may be a useful marker for the prediction of restenosis after PTCA.
Watanabe
Y
Y
Department of Cardiology, Juntendo University, Japan.
Yamada
N
N
Yokoi
H
H
Fujiwara
Y
Y
Mokuno
H
H
Daida
H
H
Yamaguchi
H
H
D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D015415:Biomarkers; D003327:Coronary Disease / Q000235:genetics* / Q000276:immunology / Q000628:therapy*; D003430:Cross-Sectional Studies; D005260:Female; D015236:HLA-C Antigens / Q000235:genetics*; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D010641:Phenotype; D012008:Recurrence
D015415:Biomarkers; D015236:HLA-C Antigens; C047431:HLA-Cw1 antigen