Comparison of cardiovascular changes after administration of gadodiamide injection and gadopentetate dimeglumine in dogs.
OBJECTIVE
The authors compared the cardiovascular effects of gadodiamide injection and gadopentetate dimeglumine.


METHODS
Gadodiamide injection or gadopentetate dimeglumine, each at doses of 0.3 or 1.5 mmol per kilogram of body weight, or saline volume control was administered intravenously in the cephalic vein of anesthetized dogs. Hemodynamic parameters, electrocardiographic parameters, and peripheral flow were measured.


RESULTS
Neither the low or high dose of gadodiamide injection caused statistically significant (P < .05) changes in any of the measured cardiovascular parameters. High doses of gadopentetate dimeglumine, however, significantly decreased left ventricular and systemic blood pressure and significantly depressed left ventricular contractility (P < .05).


CONCLUSIONS
Gadodiamide injection caused no observable cardiovascular effects, whereas high doses of gadopentetate dimeglumine caused cardio-depressive and hypotensive effects.
Bøkenes
J
J
Department of Pharmacology, Research and Development, Nycomed Imaging AS, Oslo, Norway.
Hustvedt
S O
SO
Refsum
H
H
D000818:Animals; D003287:Contrast Media / Q000008:administration & dosage / Q000633:toxicity*; D004285:Dogs; D004338:Drug Combinations; D005260:Female; D005682:Gadolinium / Q000008:administration & dosage / Q000633:toxicity*; D019786:Gadolinium DTPA; D006439:Hemodynamics / Q000187:drug effects*; D007275:Injections, Intravenous; D008297:Male; D008536:Meglumine / Q000008:administration & dosage / Q000633:toxicity*; D009942:Organometallic Compounds / Q000008:administration & dosage / Q000633:toxicity*; D004369:Pentetic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000633:toxicity
D003287:Contrast Media; D004338:Drug Combinations; D009942:Organometallic Compounds; D008536:Meglumine; D004369:Pentetic Acid; C064925:gadodiamide; D005682:Gadolinium; D019786:Gadolinium DTPA