Purine metabolism in HIV-1 virus-infected T lymphocyte population.
Purine nucleotide metabolism has been studied in T-lymphocyte population in healthy subjects and in AIDS bearing patients. Nucleotide content was determined by HPLC. The overall rate of purine nucleotide synthesis was measured following the incorporation of 14C-formate into the nucleotides of a T cell suspension. The authors discuss the results, which indicate interesting variations in nucleotide content and a lower nucleotide synthesis, determined by kinetic studies.
Carlucci
F
F
Istituto di Biochimica e di Enzimologia, Siena, Italy.
Tabucchi
A
A
Perrett
D
D
Pizzichini
M
M
Rosi
F
F
Pagani
R
R
Marinello
E
E
D000163:Acquired Immunodeficiency Syndrome / Q000378:metabolism*; D000328:Adult; D002851:Chromatography, High Pressure Liquid; D005260:Female; D015658:HIV Infections / Q000378:metabolism; D015497:HIV-1; D006801:Humans; D008297:Male; D008875:Middle Aged; D011685:Purine Nucleotides / Q000378:metabolism*; D013601:T-Lymphocytes / Q000378:metabolism*
D011685:Purine Nucleotides