[Surgical procedure in children with medullary thyroid gland carcinoma with reference to multiple endocrine neoplasia type II].
Between 1988 and 1995 we treated ten patients aged 7-18 years for familial MTC or MEN II syndrome with a total of 17 operations. Using these surgical procedures, 6/9 patients remained free of tumor after 0-8 years (mean 4.5 years). In conclusion, we recommend thyroidectomy [1] in children younger than 5 years of age and a family history of MEN IIa; [2] in children younger than 3 years of age, presenting the characteristic phenotype of MEN IIb, both with a positive test for mutation of the RET protooncogene [4].
Schäfer
K
K
Abteilung Kinderchirurgie, Ruprecht-Karis-Universität, Heidelberg.
Senninger
N
N
Roth
H
H
Buhr
H J
HJ
D000293:Adolescent; D018276:Carcinoma, Medullary / Q000235:genetics / Q000601:surgery*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D018813:Multiple Endocrine Neoplasia Type 2a / Q000235:genetics / Q000601:surgery*; D018814:Multiple Endocrine Neoplasia Type 2b / Q000235:genetics / Q000601:surgery*; D009364:Neoplasm Recurrence, Local / Q000235:genetics / Q000601:surgery; D012086:Reoperation; D013964:Thyroid Neoplasms / Q000235:genetics / Q000601:surgery*; D013965:Thyroidectomy
Chirurgisches Vorgehen bei Kindern mit medullärem Schilddrüsenkarzinom unter Berücksichtigung der multiplen endokrinen Neoplasie Typ II.