Comparison of analytical methods in the determination of two venlafaxine fatalities.
Two venlafaxine (Effexor)-related deaths are reported with comparison of results from the analysis of specimens using capillary gas chromatography with a nitrogen-phosphorous detector (GC-NPD) and high-performance liquid chromatography (HPLC) using a UV-vis detector. Blood concentrations in Case 1 were 7.27 micrograms/mL venlafaxine and 5.03 micrograms/mL O-desmethylvenlafaxine, and Case 2 had 89.67 micrograms/mL venlafaxine with 3.44 micrograms/mL of the desmethyl metabolite. A comparison of analytical methods and specimen concentration is presented.
Long
C
C
Saint Louis University School of Medicine, Department of Pathology, Berkeley, Missouri 63134, USA.
Crifasi
J
J
Maginn
D
D
Graham
M
M
Teas
S
S
D000328:Adult; D018687:Antidepressive Agents, Second-Generation / Q000097:blood* / Q000506:poisoning; D002849:Chromatography, Gas; D002851:Chromatography, High Pressure Liquid; D003511:Cyclohexanols / Q000097:blood* / Q000506:poisoning; D000069468:Desvenlafaxine Succinate; D062787:Drug Overdose; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D000069470:Venlafaxine Hydrochloride
D018687:Antidepressive Agents, Second-Generation; D003511:Cyclohexanols; D000069470:Venlafaxine Hydrochloride; D000069468:Desvenlafaxine Succinate