title: Pathophysiology and treatment implications of hypertension in the African-American population.
abstract: Regardless of the etiology, hypertension remains a major public health problem in African-Americans and is associated with significant morbidity and mortality. Additional data on the pathophysiology of this disease in this population are needed, as are data on the best therapies to decrease the high complication rate. Because many of the large studies on hypertension have included few African-Americans, recruitment of this ethnic group into clinical trials should be promoted. Further studies into the genetic factors in the pathophysiology of racial differences in hypertension may shed more light on this complex issue.
authors.affiliation: Clinical Hypertension Program, University Hospitals of Cleveland, Case Western Reserve University School of Medicine, Ohio, USA.
authors.forename: M
authors.initials: M
authors.lastname: Rahman
authors.forename: J G
authors.initials: JG
authors.lastname: Douglas
authors.forename: J T
authors.initials: JT
authors.lastname: Wright
mesh_terms: D000959:Antihypertensive Agents / Q000627:therapeutic use; D044383:Black People; D002318:Cardiovascular Diseases / Q000209:etiology; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000235:genetics / Q000503:physiopathology / Q000628:therapy*; D007674:Kidney Diseases / Q000209:etiology; D044469:Racial Groups; D012959:Socioeconomic Factors; D014481:United States; D001741:Black or African American
chemical_list: D000959:Antihypertensive Agents