Aortic blood momentum--the more the better for the ejecting heart in vivo?
OBJECTIVE
The aim of the present study was to test two hypotheses: (1) the momentum of the blood flowing out of the left ventricle toward the aorta (inertia force) plays an important role in the initiation of decay and the maximum rate of decay (peak (-dP/dt)) of left ventricular pressure (P); (2) a normal heart itself generates the inertia force which enhances its function.


METHODS
The contribution of the inertia force to (-dP/dt) was theoretically given as rho c alpha, where rho is the blood density, c the pulse wave velocity, and alpha the deceleration rate of aortic blood flow. The correlations of peak (-dP/dt) with rho c alpha and with the time constant (tau) of the pressure decay during isovolumic relaxation, which was considered to represent myocardial relaxation characteristics, were compared in seven dogs. We developed a method of grading the strength of the inertia force, using the phase loop of left ventricular pressure (dP/dt vs. P relation). The method was applied to the records of 25 patients with ischemic heart disease, from which high fidelity left ventricular pressure recordings were available.


RESULTS
The correlation of peak (-dP/dt) with rho c alpha was much higher than with tau (0.75 vs. -0.46). 16 of the 25 patients showed evidence of the inertia force. However, other patients showed no inertia force. The strength of the inertia force showed a significant (P < 0.05) correlation with left ventricular end-diastolic pressure (r = -0.46), cardiac index (r = 0.62), stroke volume index (r = 0.69), ejection fraction (r = 0.46), and peak (-dP/dt) (r = 0.56).


CONCLUSIONS
The inertia force of late systolic aortic flow contributed to ventricular relaxation in the normal heart.
Sugawara
M
M
Heart Institute of Japan, Tokyo Women's Medical College, Japan. prsuga@hij.twmc.ac.jp
Uchida
K
K
Kondoh
Y
Y
Magosaki
N
N
Niki
K
K
Jones
C J
CJ
Sugimachi
M
M
Sunagawa
K
K
D000368:Aged; D000818:Animals; D001011:Aorta; D001696:Biomechanical Phenomena; D004285:Dogs; D005260:Female; D006321:Heart / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008955:Models, Cardiovascular; D009200:Myocardial Contraction / Q000502:physiology*; D017202:Myocardial Ischemia / Q000503:physiopathology; D013599:Systole; D017725:Ventricular Pressure / Q000502:physiology