title: High frequencies of CYP2C19 mutations and poor metabolism of proguanil in Vanuatu.
authors.forename: A
authors.initials: A
authors.lastname: Kaneko
authors.forename: O
authors.initials: O
authors.lastname: Kaneko
authors.forename: G
authors.initials: G
authors.lastname: Taleo
authors.forename: A
authors.initials: A
authors.lastname: Björkman
authors.forename: T
authors.initials: T
authors.lastname: Kobayakawa
mesh_terms: D000483:Alleles; D000962:Antimalarials / Q000378:metabolism*; D001189:Aryl Hydrocarbon Hydroxylases; D018890:Chemoprevention; D065731:Cytochrome P-450 CYP2C19; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics*; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D016778:Malaria, Falciparum / Q000517:prevention & control; D006899:Mixed Function Oxygenases / Q000235:genetics*; D009154:Mutation; D016133:Polymerase Chain Reaction; D002727:Proguanil / Q000378:metabolism*; D009514:Vanuatu
chemical_list: D000962:Antimalarials; D003577:Cytochrome P-450 Enzyme System; D006899:Mixed Function Oxygenases; D001189:Aryl Hydrocarbon Hydroxylases; C045793:CYP2C19 protein, human; D065731:Cytochrome P-450 CYP2C19; D002727:Proguanil