Urinary excretion of deprenyl metabolites.
(+)-Deprenyl metabolites in rat's urine, such as nordeprenyl. methamphetamine amphetamine and p-hydroxy. methamphetamine were identified by HPLC-MS. After oral administration of 10 mg of pure (-)- and (+)-deprenyl to human volunteers, their urine was analyzed by gas chromatography. The concentration of methamphetamine was found to be overwhelming in the case of the (-)-isomer, while amphetamine and methamphetamine were excreted in equal amounts when (+)-deprenyl was administered. The metabolic processes of deprenyl resulted in metabolites possessing different lipophilicity, as it has been shown by planar displacement chromatography.
Lengyel
J
J
Central Isotope Laboratory, Semmelweis University of Medicine, Budapest, Hungary.
Magyar
K
K
Hollósi
I
I
Bartók
T
T
Báthori
M
M
Kalász
H
H
Fürst
S
S
D000818:Animals; D002849:Chromatography, Gas / Q000379:methods*; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D002855:Chromatography, Thin Layer / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D013058:Mass Spectrometry / Q000379:methods*; D008996:Monoamine Oxidase Inhibitors / Q000008:administration & dosage / Q000378:metabolism / Q000652:urine*; D051381:Rats; D017208:Rats, Wistar; D012642:Selegiline / Q000008:administration & dosage / Q000378:metabolism / Q000652:urine*
D008996:Monoamine Oxidase Inhibitors; D012642:Selegiline