title: Parvovirus B19 infection in AIDS patients.
abstract: Bone marrow of 61 HIV-1-infected patients and 23 control patients was examined to determine the incidence of B19 infection and its clinical impact in HIV-1-infected persons. Of the 61 HIV-infected patients studied, ages ranged from 22-47 years with a mean of 33.2 years. There was a man:woman ratio of 3.8:1. With regard to staging of HIV disease at the time of bone marrow sampling, 52 patients were CDC group 4, 5 patients were CDC group 3, and 4 patients were CDC group 2. Control patients, were not known to be HIV-1-infected, and had one of the following conditions: lymphoma, leukaemia, thrombocytopenia, thrombocytosis, anaemia, multiple myeloma, raised serum IgM. Thirteen of 61 HIV-infected patients and 0 of 23 control patients were positive for B19 DNA in bone marrow (two-tailed P value = 0.016). Within the HIV-infected group, the average haemoglobin among persons testing B19 DNA positive (n = 13) was 11.1 g/dl, compared with 11.5 g/dl among persons testing B19 DNA negative (n = 48). In conclusion, B19 persistence may be common and frequently subclinical in AIDS patients.
authors.affiliation: Department of Bacteriology, Belfast City Hospital, Northern Ireland.
authors.forename: J R
authors.initials: JR
authors.lastname: Kerr
authors.forename: D
authors.initials: D
authors.lastname: Kane
authors.forename: B
authors.initials: B
authors.lastname: Crowley
authors.forename: N
authors.initials: N
authors.lastname: Leonard
authors.forename: S
authors.initials: S
authors.lastname: O'Briain
authors.forename: P V
authors.initials: PV
authors.lastname: Coyle
authors.forename: F
authors.initials: F
authors.lastname: Mulcahy
mesh_terms: D000328:Adult; D001853:Bone Marrow / Q000821:virology; D004279:DNA, Viral / Q000302:isolation & purification*; D005260:Female; D015658:HIV Infections / Q000150:complications*; D015497:HIV-1; D006402:Hematologic Diseases / Q000821:virology; D019337:Hematologic Neoplasms / Q000821:virology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010322:Parvoviridae Infections / Q000175:diagnosis*; D016732:Parvovirus B19, Human / Q000302:isolation & purification*; D016133:Polymerase Chain Reaction; D012680:Sensitivity and Specificity
chemical_list: D004279:DNA, Viral