Delayed vasovasostomy: experimental study using fibrin glue.
We compare delayed vasectomy reversals performed in rats using fibrin glue combined with 3 transmural sutures or a conventional microsurgical technique. Forty Sprague-Dawley rats underwent bilateral vasectomy followed 2 weeks later by bilateral vasovasostomy using fibrin glue or a conventional microsurgical suture technique. Our protocol evaluated fertility rates after a 3-week mating period, sperm granuloma formation, histological changes at the anastomotic site, longitudinal tensile strength and mean testicular weight. The fibrin glue technique required significantly reduced operative time (p < 0.0005) and showed statistically lower tensile strength performance (p < 0.0005). All other parameters showed no statistical difference between the two techniques. Fibrin-glued vasovasostomy is efficient in a delayed protocol and deserves further clinical experience.
Vankemmel
O
O
Clinique Urologique, Centre Hospitalier Universitaire de Lille, France.
Rigot
J M
JM
Burnouf
T
T
Mazeman
E
E
D000818:Animals; D005298:Fertility / Q000502:physiology; D015718:Fibrin Tissue Adhesive; D005500:Follow-Up Studies; D006099:Granuloma / Q000473:pathology; D008297:Male; D008866:Microsurgery / Q000379:methods; D009929:Organ Size; D011183:Postoperative Complications / Q000473:pathology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013536:Suture Techniques; D013737:Testis / Q000473:pathology; D014014:Tissue Adhesives; D014669:Vasovasostomy / Q000379:methods*
D015718:Fibrin Tissue Adhesive; D014014:Tissue Adhesives