title: [Retrospective estimation of the frequency of heterozygous beta-thalassemia in the Crimean Tartar population. Formulation of the problem. Estimation of the gametic contribution to a mixed population from frequencies of the ABO blood group genes].
abstract: Polymorphism of the beta-thalassemia gene frequency in non-indigenous populations of Central Asia, especially Crimean Tartars, is often explained by inter-ethnic marriages. The frequencies of these marriages, however, are not sufficient to produce the observed gene frequencies. Because of this, an estimation of the extent of Uzbek gametic contribution to the ethnic group of Crimean Tartar origin was conducted using data on the frequencies of ABO blood group genes. The maximum-likelihood estimate obtained (0.325) was used to determine the heterozygous beta-thalassemia frequency of the ancestral Crimean Tartar population.
authors.forename: A Iu
authors.initials: AIu
authors.lastname: Asanov
authors.forename: A S
authors.initials: AS
authors.lastname: Sergeev
authors.forename: S D
authors.initials: SD
authors.lastname: Nurbaev
mesh_terms: D000017:ABO Blood-Group System / Q000235:genetics*; D005006:Ethnicity / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D006579:Heterozygote; D006801:Humans; D008297:Male; D010063:Ovum; D010641:Phenotype; D011110:Polymorphism, Genetic; D012189:Retrospective Studies; D013094:Spermatozoa; D014610:Uzbekistan; D017086:beta-Thalassemia / Q000235:genetics*
chemical_list: D000017:ABO Blood-Group System
vernacular_title: Retrospektivnaia otsenka chastoty geterozigotnoĭ beta-talassemii v populiatsii krymskikh tatar. Postanovka problemy. Otsenka velichiny gametnogo vklada v smeshannuiu populiatsiiu po chastotam grupp krovi sistemy ABO.