Nitric oxide donors: effects of S-nitrosoglutathione and 4-phenyl-3-furoxancarbonitrile on ocular blood flow and retinal function recovery.
It is known that NO is involved in the regulation of intraocular pressure (IOP) and retinal function recovery after ischemia. Thus, S-nitrosoglutathione (RVC-588) and 4-phenyl-3-furoxancarbonitrile (RVC-589) as NO donor and precursor, respectively, were studied in terms of their ability to increase b-wave recovery of electroretinogram (ERG) and ocular blood flow. It was found that RVC-588 increased b-wave amplitude markedly from 28% (control) to 67% (treated) and the blood flow significantly in the retina, choroid, and ciliary body. In the case of RVC-589, the b-wave recovery was significantly increased from 30% (control) to 51% (treated) but was less marked than that of RVC-588. The blood flow in the eye tissues was not significantly increased by RVC-588, but there was a clear tendency to enhance in the retina, choroid and iris. These results indicate that NO can be released effectively from S-nitrosothiols but less significantly from furoxans.
Liu
S X
SX
Institute of Ocular Pharmacology, Texas A&M University College of Medicine, College Station, USA.
Xuan
B O
BO
Chen
Z
Z
Varma
R S
RS
Chiou
G C
GC
D000818:Animals; D004596:Electroretinography; D005123:Eye / Q000098:blood supply* / Q000187:drug effects; D005260:Female; D005978:Glutathione / Q000031:analogs & derivatives* / Q000494:pharmacology; D009569:Nitric Oxide / Q000502:physiology*; D009603:Nitroso Compounds / Q000494:pharmacology*; D009798:Ocular Hypertension / Q000503:physiopathology; D010069:Oxadiazoles / Q000494:pharmacology*; D011817:Rabbits; D051381:Rats; D012160:Retina / Q000187:drug effects / Q000502:physiology* / Q000503:physiopathology; D012161:Retinal Artery / Q000502:physiology; D026422:S-Nitrosoglutathione; D014665:Vasodilator Agents / Q000494:pharmacology*
C090933:4-phenyl-3-furoxancarbonitrile; D009603:Nitroso Compounds; D010069:Oxadiazoles; D014665:Vasodilator Agents; D009569:Nitric Oxide; D026422:S-Nitrosoglutathione; D005978:Glutathione