title: Fibrosis of the lung and pleura and long-term exposure to wollastonite.
abstract: OBJECTIVE
  The purpose of this study was to determine whether long-term exposure to wollastonite causes fibrosis of the lung and pleura in humans.
  
  
  METHODS
  Forty-nine workers (mean exposure 25 years) in a Finnish limestone-wollastonite mine and mill were examined. Their work histories and symptoms of chronic bronchitis were recorded. The chest radiographs were classified according to the classification of the International Labour Office (1980); a radiographic follow-up from 1981 to 1990 was included. Spirometry and diffusion capacity were measured. Four workers underwent high-resolution computed tomography (HRCT) and bronchoalveolar lavage (BAL). Lung tissue specimens were available for 2 workers. Mineral fibers and asbestos bodies were analyzed from the BAL fluid and lung tissue specimens, which were also analyzed for lung fibrosis.
  
  
  RESULTS
  Two workers (4%) had small irregular lung opacities (ILO 1/0), 1 worker (2%) ILO 0/1 of the s/t type. HRCT revealed no parenchymal fibrosis in the 2 workers with the ILO 1/0 classification. Of the 9 workers (18%) with pleural plaques, 5 had been exposed to asbestos. Multivariate logistic regression analyses revealed no association of plaques with the duration of wollastonite or asbestos exposure. Wollastonite fibers or bodies were not found in any of the 4 workers who underwent BAL, nor in either of the workers whose lung tissue specimens were available.
  
  
  CONCLUSIONS
  No evidence was found that long-term exposure to wollastonite causes parenchymal fibrosis of the lung and pleura. Furthermore, the findings indicate that wollastonite fibers are poorly retained in human lungs.
authors.affiliation: Finnish Institute of Occupational Health, Helsinki, Finland.
authors.forename: H O
authors.initials: HO
authors.lastname: Koskinen
authors.forename: H L
authors.initials: HL
authors.lastname: Nordman
authors.forename: A J
authors.initials: AJ
authors.lastname: Zitting
authors.forename: H T
authors.initials: HT
authors.lastname: Suoranta
authors.forename: S L
authors.initials: SL
authors.lastname: Anttila
authors.forename: O S
authors.initials: OS
authors.lastname: Taikina-aho
authors.forename: R A
authors.initials: RA
authors.lastname: Luukkonen
mesh_terms: D000328:Adult; D000368:Aged; D017610:Calcium Compounds / Q000506:poisoning*; D005260:Female; D005355:Fibrosis; D005387:Finland; D005500:Follow-Up Studies; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D008906:Mining; D009784:Occupational Diseases / Q000139:chemically induced* / Q000175:diagnosis; D010994:Pleura / Q000473:pathology*; D011658:Pulmonary Fibrosis / Q000139:chemically induced* / Q000175:diagnosis; D017640:Silicates / Q000506:poisoning*
chemical_list: D017610:Calcium Compounds; D017640:Silicates; C031293:calcium silicate