Evidence suggestive of a locus on chromosome 5q31 contributing to susceptibility for schizophrenia in German and Israeli families by multipoint affected sib-pair linkage analysis.
Suggestive evidence for a potential susceptibility locus for schizophrenia at 5q31 was obtained in two family samples. Sample I consisted of 14 families with schizophrenia and revealed for the marker IL9 a lod score of 1.8 by two point lod score analysis. Sample II comprised 44 families including four from sample I and was ascertained in order to employ affected sib-pair analysis by identity by descent. A lod score of 1.8 around the marker D5S399 was obtained by multipoint analysis. The lod score remained positive, but decreased to 1.27 when the four families from sample I were excluded in order to use sample II as a statistically independent replication sample. We propose a susceptibility locus for schizophrenia with probably minor contribution in the pedigrees under investigation.
Schwab
S G
SG
Department of Psychiatry, University of Bonn, Germany.
Eckstein
G N
GN
Hallmayer
J
J
Lerer
B
B
Albus
M
M
Borrmann
M
M
Lichtermann
D
D
Ertl
M A
MA
Maier
W
W
Wildenauer
D B
DB
D002895:Chromosomes, Human, Pair 5 / Q000235:genetics*; D004198:Disease Susceptibility; D005838:Genotype; D005858:Germany / Q000453:epidemiology; D006801:Humans; D007557:Israel / Q000453:epidemiology; D008126:Lod Score; D008957:Models, Genetic; D010375:Pedigree; D011618:Psychotic Disorders / Q000453:epidemiology / Q000235:genetics; D012559:Schizophrenia / Q000453:epidemiology / Q000235:genetics*