title: Measurement and metabolism of isoflavonoids and lignans in the human male.
abstract: Asian men, who consume a low fat/high fibre soya-based diet, have very much lower incidence of prostate cancer than men from North America and Europe. The soya bean is a rich source of the isoflavonic phyto-oestrogens, daidzein, genistein and equol, compounds which may be cancer-protective in Asian populations. The lignans, enterolactone and enterodiol, plant oestrogens derived from cereals and vegetables, may act in a similar manner in vegetarian men. We report here on the measurement of isoflavonoids and lignans, by gas chromatography-mass spectrometry, in prostatic fluid of men from Asia and Europe and also on the metabolism of these compounds in Western men following dietary supplementation.
authors.affiliation: Tenovus Cancer Research Centre, U.W.C.M., Cardiff, UK.
authors.forename: M S
authors.initials: MS
authors.lastname: Morton
authors.forename: A
authors.initials: A
authors.lastname: Matos-Ferreira
authors.forename: L
authors.initials: L
authors.lastname: Abranches-Monteiro
authors.forename: R
authors.initials: R
authors.lastname: Correia
authors.forename: N
authors.initials: N
authors.lastname: Blacklock
authors.forename: P S
authors.initials: PS
authors.lastname: Chan
authors.forename: C
authors.initials: C
authors.lastname: Cheng
authors.forename: S
authors.initials: S
authors.lastname: Lloyd
authors.forename: W
authors.initials: W
authors.lastname: Chieh-ping
authors.forename: K
authors.initials: K
authors.lastname: Griffiths
mesh_terms: D000328:Adult; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D007529:Isoflavones / Q000032:analysis* / Q000378:metabolism*; D017705:Lignans / Q000032:analysis* / Q000378:metabolism*; D008043:Linseed Oil / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011467:Prostate / Q000378:metabolism*; D013025:Glycine max / Q000378:metabolism*; D013997:Time Factors
chemical_list: D007529:Isoflavones; D017705:Lignans; D008043:Linseed Oil