title: International Cooperative Ataxia Rating Scale for pharmacological assessment of the cerebellar syndrome. The Ataxia Neuropharmacology Committee of the World Federation of Neurology.
abstract: Despite the involvement of cerebellar ataxia in a large variety of conditions and its frequent association with other neurological symptoms, the quantification of the specific core of the cerebellar syndrome is possible and useful in Neurology. Recent studies have shown that cerebellar ataxia might be sensitive to various types of pharmacological agents, but the scales used for assessment were all different. With the long-term goal of double-blind controlled trials-multicentric and international-an ad hoc Committee of the World Federation of Neurology has worked to propose a one-hundred-point semi-quantitative International Cooperative Ataxia Rating Scale (ICARS). The scale proposed involves a compartimentalized quantification of postural and stance disorders, limb ataxia, dysarthria and oculomotor disorders, in order that a subscore concerning these symptoms may be separately studied. The weight of each symptomatologic compartment has been carefully designed. The members of the Committee agreed upon precise definitions of the tests, to minimize interobserver variations. The validation of this scale is in progress.
authors.affiliation: Ataxia Research Center, Hôpital Neurologique and Claude Bernard University, Lyon, France.
authors.forename: P
authors.initials: P
authors.lastname: Trouillas
authors.forename: T
authors.initials: T
authors.lastname: Takayanagi
authors.forename: M
authors.initials: M
authors.lastname: Hallett
authors.forename: R D
authors.initials: RD
authors.lastname: Currier
authors.forename: S H
authors.initials: SH
authors.lastname: Subramony
authors.forename: K
authors.initials: K
authors.lastname: Wessel
authors.forename: A
authors.initials: A
authors.lastname: Bryer
authors.forename: H C
authors.initials: HC
authors.lastname: Diener
authors.forename: S
authors.initials: S
authors.lastname: Massaquoi
authors.forename: C M
authors.initials: CM
authors.lastname: Gomez
authors.forename: P
authors.initials: P
authors.lastname: Coutinho
authors.forename: M
authors.initials: M
authors.lastname: Ben Hamida
authors.forename: G
authors.initials: G
authors.lastname: Campanella
authors.forename: A
authors.initials: A
authors.lastname: Filla
authors.forename: L
authors.initials: L
authors.lastname: Schut
authors.forename: D
authors.initials: D
authors.lastname: Timann
authors.forename: J
authors.initials: J
authors.lastname: Honnorat
authors.forename: N
authors.initials: N
authors.lastname: Nighoghossian
authors.forename: B
authors.initials: B
authors.lastname: Manyam
mesh_terms: D002524:Cerebellar Ataxia / Q000175:diagnosis / Q000503:physiopathology*; D005684:Gait / Q000502:physiology; D006801:Humans; D007596:Joints / Q000503:physiopathology; D009068:Movement / Q000502:physiology; D009801:Oculomotor Muscles / Q000503:physiopathology; D011187:Posture; D011597:Psychomotor Performance / Q000502:physiology; D012015:Reference Standards; D013064:Speech Disorders / Q000175:diagnosis / Q000503:physiopathology; D014202:Tremor / Q000175:diagnosis / Q000503:physiopathology; D016138:Walking