The effects of IFN-gamma activated mouse peritoneal and alveolar macrophages on Cryptosporidium parvum development.
Mouse peritoneal and alveolar macrophages were interacted in vitro with C. parvum oocysts and cultured in normal medium and in medium with IFN-gamma. The results showed that in vitro activation of macrophages by IFN-gamma limits C. parvum development although the inhibitory effect is not as potent as in other intracellular parasitic protozoa.
Martinez
F
F
Institute of Biotechnology, School of Science, University of Granada, Spain.
Rosales
M J
MJ
Diaz
J
J
Mascaro
C
C
D000818:Animals; D002478:Cells, Cultured; D016785:Cryptosporidium parvum / Q000254:growth & development*; D007371:Interferon-gamma / Q000494:pharmacology*; D008262:Macrophage Activation; D016676:Macrophages, Alveolar / Q000187:drug effects / Q000276:immunology* / Q000469:parasitology*; D017737:Macrophages, Peritoneal / Q000187:drug effects / Q000276:immunology* / Q000469:parasitology*; D051379:Mice; D013997:Time Factors
D007371:Interferon-gamma