Anterior chamber concentrations of vancomycin in the irrigating solution at the end of cataract surgery.
OBJECTIVE
To verify that therapeutic levels of vancomycin were present in the irrigating solution at the end of cataract surgery.


METHODS
Service d'ophtalmologie, Université de Limoges, France.


METHODS
An irrigating solution that contained 20 mg/L of vancomycin was used in 15 patients having phacoemulsification. Antibiotic concentrations in the phacoemulsification handpiece and in the aqueous humor were measured at the end of surgery.


RESULTS
Passage through the phacoemulsifier did not affect antibiotic concentration. In the aqueous humor, after wound closure, the concentration constantly exceeded the minimal inhibitory concentration of the principal gram-positive bacteria responsible for human endophthalmitis.


CONCLUSIONS
Vancomycin added to the irrigating solution used during cataract surgery was found in effective concentrations in the anterior chamber at the end of surgery.
Adenis
J P
JP
Service d'ophtalmologie, Université de Limoges, Faculté de Médecine, France.
Robert
P Y
PY
Mounier
M
M
Denis
F
F
D000368:Aged; D000369:Aged, 80 and over; D000867:Anterior Chamber / Q000378:metabolism*; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use; D019072:Antibiotic Prophylaxis / Q000379:methods; D001082:Aqueous Humor / Q000378:metabolism; D009877:Endophthalmitis / Q000517:prevention & control; D015818:Eye Infections, Bacterial / Q000517:prevention & control; D005260:Female; D006801:Humans; D007432:Intraoperative Period; D008297:Male; D008875:Middle Aged; D018918:Phacoemulsification / Q000379:methods*; D011183:Postoperative Complications / Q000517:prevention & control; D007507:Therapeutic Irrigation; D014640:Vancomycin / Q000008:administration & dosage / Q000493:pharmacokinetics*
D000900:Anti-Bacterial Agents; D014640:Vancomycin