[Causal relationship between GBV-C and fulminant hepatitis].
GBV-C is recently discovered RNA virus which appeared to be member of Flaviviridae. We previously reported the possible involvement of GBV-C in the etiology of fulminant hepatitis(FH). It is still controversial whether GBV-C cause FH. So far, the only reliable tool for the diagnosis of GBV-C is the detection of the viral genome using PCR. Detection of GBV-C in serum of patient with FH dose not necessarily mean that GBV-C is causal virus. Serial quantification of serum GBV-C RNA in patient with FH may reveal a pathogenetic role of GBV-C. Further study is needed to elucidate the relationship between FH and a specific strain of GBV-C.
Inoue
K
K
Showa University Fujigaoka Hospital, Division of Gastroenterology.
Yoshiba
M
M
Sekiyama
K
K
D001483:Base Sequence; D018067:Flaviviridae / Q000235:genetics / Q000302:isolation & purification / Q000472:pathogenicity*; D016679:Genome, Viral; D006525:Hepatitis, Viral, Human / Q000821:virology*; D006801:Humans; D016133:Polymerase Chain Reaction; D012367:RNA, Viral / Q000097:blood*; D014158:Transcription, Genetic
D012367:RNA, Viral