[The role of the vasoconstrictor effect in realizing the radioprotective properties of indralin in experiments on dogs].
In the experiments on dogs, the role of a pharmacological circulatory hypoxia in the mechanism of radioprotective effect of indraline and mexamine was studied. Angiography revealed 20-40% vasoconstriction of major arteries of legs of animals, of pelvis and abdomen caused by mexamine (10 mg/kg) and the absence of a significant effect of indraline. Disruption of a regional blood circulation in the marrow and spleen (40-50% and 70-80%, respectively) was caused by indraline to the same extent as by mexamine. For indraline, a decrease in pO2 in the marrow was about 50%. With these hemodynamic disturbances, indraline showed 80 to 100% radioprotective effect, while mexamine was inefficient. Acute hypoxic hypoxia (5-7% O2) increased a post-radiation survival rate for dogs by 40%. The radioprotective effect of indraline was blocked by tropaphen and reduced in cases of breathing with pure oxygen. Splenectomy has no effect on radioprotective properties of indraline. Thus, a hypothesis of the mechanism of a radioprotective effect of alpha-adrenomimetics was proposed.
Vasin
M V
MV
Antipov
V V
VV
Chernov
G A
GA
Abramov
M M
MM
Gavriliuk
D N
DN
L'vova
T S
TS
Suvorov
N N
NN
D008735:5-Methoxytryptamine / Q000627:therapeutic use; D000208:Acute Disease; D000818:Animals; D003538:Cystamine / Q000627:therapeutic use; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D005260:Female; D005720:Gamma Rays; D000860:Hypoxia / Q000503:physiopathology; D008297:Male; D009584:Nitrogen; D010100:Oxygen; D010636:Phenols / Q000627:therapeutic use*; D011833:Radiation Injuries, Experimental / Q000188:drug therapy / Q000503:physiopathology; D011837:Radiation-Protective Agents / Q000627:therapeutic use*; D013997:Time Factors; D014662:Vasoconstrictor Agents / Q000627:therapeutic use*
D010636:Phenols; D011837:Radiation-Protective Agents; D014662:Vasoconstrictor Agents; C086896:indralin; C041364:nitrox; D008735:5-Methoxytryptamine; D009584:Nitrogen; D003538:Cystamine; D010100:Oxygen
Rol' vazokonstriktornogo éffekta v realizatsii protivoluchevykh svoĭstv indralina v opytakh na sobakakh.