title: ERP assessment of visual and auditory language processing in schizophrenia.
abstract: Language disturbance in schizophrenia has been recently attributed to disturbed priming mechanisms. In the present study, event-related potentials (ERPs), were recorded to final words in sentences presented to 13 chronic patients with schizophrenia and 12 normal controls. Half of the final words fit a sentence context and another half did not. The N400 (the ERP sensitive to language) latency was prolonged, and its amplitude was more negative to both correct and incorrect sentence endings in the group with schizophrenia relative to the group of normal controls. The early ERP components, N100 and P200, were similar in both groups. These results suggest that language abnormalities in schizophrenia are related to a dysfunction in the language system and not to a general cognitive dysfunction, and may be related to poor use of context in patients with schizophrenia.
authors.affiliation: Department of Psychiatry, Harvard Medical School, Massachusetts, USA. mnizniki@warren.med.harvard.edu
authors.forename: M A
authors.initials: MA
authors.lastname: Niznikiewicz
authors.forename: B F
authors.initials: BF
authors.lastname: O'Donnell
authors.forename: P G
authors.initials: PG
authors.lastname: Nestor
authors.forename: L
authors.initials: L
authors.lastname: Smith
authors.forename: S
authors.initials: S
authors.lastname: Law
authors.forename: M
authors.initials: M
authors.lastname: Karapelou
authors.forename: M E
authors.initials: ME
authors.lastname: Shenton
authors.forename: R W
authors.initials: RW
authors.lastname: McCarley
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D005074:Evoked Potentials, Visual / Q000502:physiology*; D006801:Humans; D007806:Language Disorders / Q000209:etiology / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011932:Reading; D012559:Schizophrenia / Q000150:complications / Q000503:physiopathology*; D013067:Speech Perception / Q000502:physiology*