Comparative effects of beta2-adrenergic agonists on muscle waste associated with tumour growth.
The implantation of the Yoshida AH-130 ascites hepatoma (a fast growing tumour) to rats resulted in a dramatic loss of both white adipose tissue and muscle (skeletal and cardiac) mass. Administration of beta2-adrenergic agonists to tumour-bearing rats resulted in a partial recovery of skeletal muscle and heart mass. Treatment of the tumour-bearing animals with the different drugs (salbutamol, salmeterol and clenbuterol) did not influence tumour growth or food intake so it can be suggested that the effects were solely due to metabolic changes. In addition, while the three drugs had clear effects on gastrocnemius muscles, clenbuterol and salbutamol had also an effect on soleus, and salbutamol had a clear effect on cardiac muscle. It is suggested that any of the studied beta2-adrenergic agonists (but perhaps, particularly salmeterol) could be used clinically in the treatment of cancer cachexia.
Carbó
N
N
Departament de Bioquímica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Spain.
López-Soriano
J
J
Tarragó
T
T
González
O
O
Llovera
M
M
López-Soriano
F J
FJ
Argilés
J M
JM
D000273:Adipose Tissue / Q000187:drug effects; D000318:Adrenergic beta-Agonists / Q000494:pharmacology*; D000420:Albuterol / Q000031:analogs & derivatives / Q000494:pharmacology; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002100:Cachexia / Q000209:etiology; D002976:Clenbuterol / Q000494:pharmacology; D004435:Eating / Q000187:drug effects; D008114:Liver Neoplasms, Experimental / Q000150:complications*; D008297:Male; D009124:Muscle Proteins / Q000187:drug effects*; D009133:Muscular Atrophy / Q000188:drug therapy*; D051381:Rats; D017208:Rats, Wistar; D000068299:Salmeterol Xinafoate
D000318:Adrenergic beta-Agonists; D009124:Muscle Proteins; D000068299:Salmeterol Xinafoate; D000420:Albuterol; D002976:Clenbuterol