title: Evidence suggestive of a locus on chromosome 5q31 contributing to susceptibility for schizophrenia in German and Israeli families by multipoint affected sib-pair linkage analysis.
abstract: Suggestive evidence for a potential susceptibility locus for schizophrenia at 5q31 was obtained in two family samples. Sample I consisted of 14 families with schizophrenia and revealed for the marker IL9 a lod score of 1.8 by two point lod score analysis. Sample II comprised 44 families including four from sample I and was ascertained in order to employ affected sib-pair analysis by identity by descent. A lod score of 1.8 around the marker D5S399 was obtained by multipoint analysis. The lod score remained positive, but decreased to 1.27 when the four families from sample I were excluded in order to use sample II as a statistically independent replication sample. We propose a susceptibility locus for schizophrenia with probably minor contribution in the pedigrees under investigation.
authors.affiliation: Department of Psychiatry, University of Bonn, Germany.
authors.forename: S G
authors.initials: SG
authors.lastname: Schwab
authors.forename: G N
authors.initials: GN
authors.lastname: Eckstein
authors.forename: J
authors.initials: J
authors.lastname: Hallmayer
authors.forename: B
authors.initials: B
authors.lastname: Lerer
authors.forename: M
authors.initials: M
authors.lastname: Albus
authors.forename: M
authors.initials: M
authors.lastname: Borrmann
authors.forename: D
authors.initials: D
authors.lastname: Lichtermann
authors.forename: M A
authors.initials: MA
authors.lastname: Ertl
authors.forename: W
authors.initials: W
authors.lastname: Maier
authors.forename: D B
authors.initials: DB
authors.lastname: Wildenauer
mesh_terms: D002895:Chromosomes, Human, Pair 5 / Q000235:genetics*; D004198:Disease Susceptibility; D005838:Genotype; D005858:Germany / Q000453:epidemiology; D006801:Humans; D007557:Israel / Q000453:epidemiology; D008126:Lod Score; D008957:Models, Genetic; D010375:Pedigree; D011618:Psychotic Disorders / Q000453:epidemiology / Q000235:genetics; D012559:Schizophrenia / Q000453:epidemiology / Q000235:genetics*