Genotype of cytochrome P450 2E1 and alcohol-related blood pressure elevation in Japanese men.
Three-hundred-and-sixty-seven unrelated Japanese male workers aged between 36 and 61 years were analysed for the genotypes of cytochrome P450 2E1 (CYP2E1), and the association with alcohol-related health effects including blood pressure (BP) elevation. Homozygous for the c1 (wild) gene was found in 204 men (55%), homozygous for the c2 (variant) gene in 17 (5%), and heterozygous in 146 (40%). Arithmetic means of alcohol consumed per week in the genotypes of c1/c1, c1/c2 and c2/c2 were 218, 257 and 211 g, respectively, and were not statistically different. BP was elevated with the increase in alcohol consumption, and was significantly higher in the c2/c2 genotype than in the other genotypes among the subjects consuming 200 g or more of alcohol per week. Serum uric acid did not correlate with alcohol consumption in the whole subjects, but it was also higher in drinkers having the c2/c2 genotype. Although the number of subjects was too small for a definite conclusion to be drawn, these results suggest to some extent that Japanese men having the c2/c2 genotype of CYP2E1 are more sensitive to the pressor effect of alcohol. Further studies are required to confirm this.
Yamada
Y
Y
Department of Hygiene, Kanazawa Medical University Uchinada, Ishikawa, Japan.
Ikai
E
E
Honda
R
R
Tsuritani
I
I
D000328:Adult; D000428:Alcohol Drinking; D044466:Asian People / Q000235:genetics*; D001794:Blood Pressure / Q000187:drug effects* / Q000235:genetics; D019392:Cytochrome P-450 CYP2E1 / Q000235:genetics*; D005838:Genotype; D006801:Humans; D007564:Japan / Q000208:ethnology; D008297:Male; D008875:Middle Aged
D019392:Cytochrome P-450 CYP2E1