title: Flavonol and chalcone ester glycosides from Bidens leucantha.
abstract: Four new flavonol 7-O-glycosides 1-4 and a new chalcone ester glycoside 5 have been isolated from the leaves of Bidens leucantha along with four known chalcone ester glycosides 6-9. Their structures were elucidated using a combination of spectroscopic techniques. The in vitro anti-HIV activity of all the compounds was tested as part of our screening of potential anti-AIDS agents from medicinal plants. Although none of the flavonol glycosides was active, a moderate inhibitory effect on viral replication was exerted by chalcone ester glycoside 9.
authors.affiliation: Centro Interdipartimentale di Chimica, Biologia e Technologie Farmaceutiche, Università degli Studi di Salerno, Italy.
authors.forename: N
authors.initials: N
authors.lastname: De Tommasi
authors.forename: C
authors.initials: C
authors.lastname: Pizza
authors.forename: R
authors.initials: R
authors.lastname: Aquino
authors.forename: J
authors.initials: J
authors.lastname: Cumandà
authors.forename: N
authors.initials: N
authors.lastname: Mahmood
mesh_terms: D019380:Anti-HIV Agents / Q000302:isolation & purification* / Q000494:pharmacology; D002460:Cell Line; D002599:Chalcone / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D044948:Flavonols; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015497:HIV-1 / Q000187:drug effects; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D010946:Plants, Medicinal / Q000737:chemistry*; D016339:Spectrometry, Mass, Fast Atom Bombardment; D014779:Virus Replication / Q000187:drug effects
chemical_list: D019380:Anti-HIV Agents; D005419:Flavonoids; D044948:Flavonols; D006027:Glycosides; D002599:Chalcone