title: The proteasome.
abstract: The proteasome is a macromolecular assembly that is designed to confine proteolytic activity to an inner cavity. Access to the central proteolytic nanocompartment is restricted to unfolded proteins, which necessitates a functional coupling of the 20S proteasome to a substrate-recognition and unfolding machinery. Significant progress has been made during the past two years in elucidating the structural principles and the enzymatic mechanism of the 20S proteasome.
authors.affiliation: Max-Planck-Institut für Biochemie, Department of Structural Biology, D-82152, Martinsried b. München, Germany. baumeist@alf.biochem.mpg.de
authors.forename: W
authors.initials: W
authors.lastname: Baumeister
authors.forename: A
authors.initials: A
authors.lastname: Lupas
mesh_terms: D003546:Cysteine Endopeptidases / Q000648:ultrastructure*; D008854:Microscopy, Electron; D008958:Models, Molecular; D009097:Multienzyme Complexes / Q000648:ultrastructure*; D046988:Proteasome Endopeptidase Complex; D017433:Protein Structure, Secondary; D017434:Protein Structure, Tertiary; D013822:Thermoplasma
chemical_list: D009097:Multienzyme Complexes; D003546:Cysteine Endopeptidases; D046988:Proteasome Endopeptidase Complex