Does subclinical hypothyroidism explain the increased susceptibility of women to torsades de pointes?
Among 20 consecutive patients (65% women) with drug-associated torsades de pointes, chemical evidence for hypothyroidism was found in only 10% of both women and men. Subclinical hypothyroidism is therefore unlikely to account for the consistently observed sex difference in the propensity to torsades de pointes.
Lehmann
M H
MH
The Arrhythmia Center and Department of Medicine/Sinai Hospital, Detroit, Michigan 48235, USA.
Frankovich
D
D
Baga
J J
JJ
Pires
L A
LA
Schuger
C D
CD
Steinman
R T
RT
Rabinowe
S L
SL
D000368:Aged; D000889:Anti-Arrhythmia Agents / Q000009:adverse effects* / Q000627:therapeutic use; D004198:Disease Susceptibility; D004562:Electrocardiography; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology; D008297:Male; D012307:Risk Factors; D012737:Sex Factors; D016171:Torsades de Pointes / Q000139:chemically induced* / Q000453:epidemiology / Q000209:etiology
D000889:Anti-Arrhythmia Agents