title: Genes involved in T-cell receptor-mediated apoptosis of thymocytes and T-cell hybridomas.
abstract: Stimulation of the T-cell receptor complex in resting T cells leads to activation. However, antigenic stimulation of immature T lymphocytes and activated mature T cells results in apoptosis. Recent work suggests that distinct signaling pathways in T cells mediate cell death and cell activation. In this article, genes that are involved in apoptosis of immature T cells and T-cell hybridomas are discussed.
authors.affiliation: Department of Molecular & Cell Biology, UC Berkeley 94720-3200, USA.
authors.forename: A
authors.initials: A
authors.lastname: Winoto
mesh_terms: D017209:Apoptosis / Q000235:genetics*; D004268:DNA-Binding Proteins / Q000235:genetics; D006825:Hybridomas; D017730:Ki-1 Antigen / Q000235:genetics; D057105:Nuclear Receptor Subfamily 4, Group A, Member 1; D011948:Receptors, Antigen, T-Cell / Q000378:metabolism; D018160:Receptors, Cytoplasmic and Nuclear; D011987:Receptors, Steroid; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000276:immunology*; D013950:Thymus Gland / Q000166:cytology / Q000276:immunology*; D014157:Transcription Factors / Q000235:genetics; D019014:fas Receptor / Q000235:genetics
chemical_list: D004268:DNA-Binding Proteins; D017730:Ki-1 Antigen; D057105:Nuclear Receptor Subfamily 4, Group A, Member 1; D011948:Receptors, Antigen, T-Cell; D018160:Receptors, Cytoplasmic and Nuclear; D011987:Receptors, Steroid; D014157:Transcription Factors; D019014:fas Receptor