title: Diet and calorie restriction.
abstract: Current data suggest that the life spans of commonly held rodent species have decreased and the occurrence of tumors occurs earlier in the lifespan of ad libitum-fed animals. The most likely cause of this change in the life span of barrier-reared genetically defined animals is increased body weight. The effects of caloric restriction on a variety of functional measures and on age-dependent tumors and lesions are the focus of this presentation. Recommendations for caloric restriction, or at least "dietary control," will be discussed.
authors.affiliation: Biology of Aging Program, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA.
authors.forename: R L
authors.initials: RL
authors.lastname: Sprott
mesh_terms: D000818:Animals; D001835:Body Weight / Q000502:physiology; D004032:Diet; D002149:Energy Intake; D005260:Female; D008136:Longevity / Q000502:physiology*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D051381:Rats; D011919:Rats, Inbred Strains