Physiopathology of H3-receptors and pharmacology of betahistine.
This article reviews published research on the physiology of histamine H3-receptors. The function of this inhibitory autoreceptor, its localisation and influence on histaminergic neurones as well as histamine-controlled processes are presented together with the role of H3-receptors in the vestibular system. In addition to a summary of the properties of the main H3-agonists and -antagonists, the pharmacology of betahistine and its place in the treatment of vertigo are discussed.
Van Cauwenberge
P B
PB
Department of Otorhinolaryngology, University Hospital of Ghent, Belgium.
De Moor
S E
SE
D000818:Animals; D001621:Betahistine / Q000494:pharmacology*; D017442:Histamine Agonists / Q000494:pharmacology*; D006801:Humans; D018100:Receptors, Histamine H3 / Q000502:physiology*; D014722:Vestibule, Labyrinth / Q000187:drug effects / Q000502:physiology*
D017442:Histamine Agonists; D018100:Receptors, Histamine H3; D001621:Betahistine