Successful treatment of sclerosing cervicitis and fibrosing mediastinitis with tamoxifen.
Fibrosing mediastinitis and sclerosing cervicitis are fibrosclerotic disorders akin to retroperitoneal fibrosis, with presenting symptoms related to local pain or viscus obstruction or both. No definitive treatment is known. This is the first report of these disorders dramatically responding to tamoxifen citrate and prednisone.
Savelli
B A
BA
Providence Medical Center, Department of Medical Education, Oregon Health Sciences University, Portland, USA.
Parshley
M
M
Morganroth
M L
ML
D000328:Adult; D016588:Anticarcinogenic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D005355:Fibrosis; D006801:Humans; D008480:Mediastinitis / Q000188:drug therapy*; D009333:Neck / Q000473:pathology*; D011241:Prednisone / Q000008:administration & dosage; D012598:Sclerosis; D013629:Tamoxifen / Q000008:administration & dosage / Q000627:therapeutic use*
D016588:Anticarcinogenic Agents; D013629:Tamoxifen; D011241:Prednisone