title: Response to an iron fortification programme in relation to vitamin A status in 6-12-year-old school children.
abstract: Plasma retinol and indices of iron status were measured in 148 school children (6-12 years) receiving a soup fortified with iron and vitamin C for a period of 15 weeks. The most significant change in serum iron (P = 0.0005) and transferrin saturation (P = 0.0002) was seen in subjects with plasma retinol > or = 40 micrograms/dl, while subjects with plasma retinol < 20 micrograms/dl showed no response. Serum ferritin improved most in the retinol categories < 40 micrograms/dl, suggesting that the absorption of iron was not impaired by marginal vitamin A status, but that it was rather the mobilisation of iron from stores that was affected. Changes in vitamin A status correlated positively and significantly with changes in serum iron (r = 0.37; P = 0.0001) transferrin saturation (r = 0.27; P = 0.004) and haemoglobin (r = 0.21; P = 0.03), but negatively with serum ferritin (r = -0.28; P = 0.003). The presence of marginal vitamin A deficiency in a community may limit the effectiveness of an iron intervention programme and vitamin A status should therefore also be considered when such programmes are planned.
authors.affiliation: National Research Programme for Nutritional Intervention, Medical Research Council, Parow, South Africa.
authors.forename: M E
authors.initials: ME
authors.lastname: van Stuijvenberg
authors.forename: M
authors.initials: M
authors.lastname: Kruger
authors.forename: C J
authors.initials: CJ
authors.lastname: Badenhorst
authors.forename: E P
authors.initials: EP
authors.lastname: Mansvelt
authors.forename: J A
authors.initials: JA
authors.lastname: Laubscher
mesh_terms: D001205:Ascorbic Acid / Q000008:administration & dosage*; D002648:Child; D005293:Ferritins / Q000378:metabolism; D005527:Food, Fortified; D006400:Hematocrit; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007501:Iron / Q000008:administration & dosage* / Q000097:blood; D009752:Nutritional Status; D013019:South Africa; D014168:Transferrin / Q000378:metabolism; D014801:Vitamin A / Q000097:blood*
chemical_list: D006454:Hemoglobins; D014168:Transferrin; D014801:Vitamin A; D005293:Ferritins; D007501:Iron; D001205:Ascorbic Acid