title: Retarded development of exoerythrocytic stages of the rodent malaria parasite Plasmodium berghei in human hepatoma cells by extracts from Dioncophyllaceae and Ancistrocladaceae species.
abstract: Retarded development of exoerythrocytic stages of the rodent malaria parasite Plasmodium berghei in human hepatoma cells by extracts from Dioncophyllaceae and Ancistrocladaceae species. International Journal for Parasitology 27: 29-32. Naphthylisoquinoline alkaloid-containing extracts (10 micrograms ml-1) of species belonging to the Dioncophyllaceae and the Ancistrocladaceae, 2 small tropical plant families, display pronounced in vitro activities against exoerythrocytic stages of Plasmodium berghei (Anka), developing in human hepatoma cells (Hep G2). The highest activities were obtained with CH2Cl2 root and bark extracts, and a CH2Cl2/NH3 leaf extract from Triphyophyllum peltatum, a CH2Cl2/NH3 root extract from Ancistrocladus abbreviatus, and a CH2Cl2 leaf extract from A. tectorius. The degrees of growth inhibition ranged within 27.7-70.0%. The commercially available drug primaquine diphosphate (25 micrograms ml-1) caused a comparable effect (62.1%) in the same test system.
authors.affiliation: Prins Leopold Instituut voor Tropische Geneeskunde, Antwerpen, Belgium.
authors.forename: G
authors.initials: G
authors.lastname: François
authors.forename: T
authors.initials: T
authors.lastname: Steenackers
authors.forename: G
authors.initials: G
authors.lastname: Timperman
authors.forename: L
authors.initials: L
authors.lastname: Aké Assi
authors.forename: R D
authors.initials: RD
authors.lastname: Haller
authors.forename: S
authors.initials: S
authors.lastname: Bär
authors.forename: M A
authors.initials: MA
authors.lastname: Isahakia
authors.forename: S A
authors.initials: SA
authors.lastname: Robertson
authors.forename: C
authors.initials: C
authors.lastname: Zhao
authors.forename: N J
authors.initials: NJ
authors.lastname: De Souza
authors.forename: J
authors.initials: J
authors.lastname: Holenz
authors.forename: G
authors.initials: G
authors.lastname: Bringmann
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D006528:Carcinoma, Hepatocellular; D002460:Cell Line; D006801:Humans; D008113:Liver Neoplasms; D008288:Malaria / Q000503:physiopathology*; D008519:Medicine, Traditional; D010936:Plant Extracts / Q000494:pharmacology*; D018517:Plant Roots; D018547:Plant Stems; D010946:Plants, Medicinal; D010962:Plasmodium berghei / Q000187:drug effects / Q000502:physiology*; D012377:Rodentia; D014407:Tumor Cells, Cultured
chemical_list: D000962:Antimalarials; D010936:Plant Extracts