A magnetization transfer study of white matter in siblings of multiple sclerosis patients.
In this study, we evaluated magnetization transfer ratio values in the brain white matter of siblings of multiple sclerosis (MS) patients and compared them to those obtained in sex- and age-matched normal controls. No statistically significant difference was found between the two groups for all the white matter areas studied (frontal and occipital lobes, centrum semiovale, periventricular white matter, internal capsule, genu and splenium of the corpus callosum).
Filippi
M
M
Department of Neurology, Scientific Institute Ospedale San Raffaele, University of Milan, Italy.
Campi
A
A
Martino
G
G
Colombo
B
B
Comi
G
G
D000328:Adult; D003337:Corpus Callosum / Q000473:pathology; D005192:Family Health; D005260:Female; D005625:Frontal Lobe / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D016555:Matched-Pair Analysis; D009103:Multiple Sclerosis / Q000453:epidemiology / Q000473:pathology*; D009412:Nerve Fibers / Q000473:pathology; D009679:Nuclear Family; D012307:Risk Factors