title: Successful excision of hemorrhagic cavernous angioma in a patient with severe factor VII deficiency: perioperative treatment with factor VII concentrate.
abstract: A case of an uncomplicated neurosurgical procedure in a patient affected by a rare bleeding disorder is described. The interest is twofold: first because of the possible influence of underlying coagulopathy in disclosing the vascular anomaly. And second although surgery in factor VII deficiency has been reported before, with and without replacement therapy, to our knowledge, this is the first neurosurgical case in which factor VII concentrate was used. This treatment allowed safe surgery and protected the patient from complications associated with plasma and protrombin complex use.
authors.affiliation: Division of Neurosurgery, San Camillo Hospital, Rome, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Brunori
authors.forename: R
authors.initials: R
authors.lastname: Greco
authors.forename: G
authors.initials: G
authors.lastname: Oddi
authors.forename: A
authors.initials: A
authors.lastname: de Blasio
authors.forename: F
authors.initials: F
authors.lastname: Chiappetta
mesh_terms: D000328:Adult; D001932:Brain Neoplasms / Q000097:blood / Q000175:diagnosis / Q000601:surgery*; D002543:Cerebral Hemorrhage / Q000097:blood / Q000175:diagnosis / Q000601:surgery*; D003399:Craniotomy; D005167:Factor VII / Q000008:administration & dosage*; D005168:Factor VII Deficiency / Q000097:blood / Q000150:complications / Q000601:surgery*; D006392:Hemangioma, Cavernous / Q000097:blood / Q000175:diagnosis / Q000601:surgery*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008866:Microsurgery; D010296:Parietal Lobe / Q000473:pathology / Q000601:surgery; D011292:Premedication
chemical_list: D005167:Factor VII