title: Avian influenza A virus induced stunting syndrome-like disease in chicks.
abstract: Two-day-old specific-pathogen free chicks were inoculated with type A influenza virus (A/whistling swan/Shimane/499/83 (H5N3) through the air sac. Inoculated chicks showed mild to severe diarrhea and lesions of pancreatitis and atrophy of the pancreas, thymus and bursa of Fabricius. One chick died on each of days 4, 6 and 14 postinoculation (PI). Reduced weight gain was conspicuous from day 22 PI. Positive immunoreaction to the virus antigen was detected in the pancreas, kidneys, liver, lungs and air sacs, and cecal lamina propria. Virus recovery persisted longer in the pancreas. Some of these findings conformed to those of stunting syndrome.
authors.affiliation: Department of Veterinary Pathology, Faculty of Agriculture, Tottori University, Japan.
authors.forename: F D
authors.initials: FD
authors.lastname: Silvano
authors.forename: Y
authors.initials: Y
authors.lastname: Kanata
authors.forename: M
authors.initials: M
authors.lastname: Takeuchi
authors.forename: A
authors.initials: A
authors.lastname: Shimada
authors.forename: K
authors.initials: K
authors.lastname: Otsuki
authors.forename: T
authors.initials: T
authors.lastname: Umemura
mesh_terms: D000400:Air Sacs / Q000276:immunology / Q000821:virology; D000818:Animals; D000956:Antigens, Viral / Q000032:analysis / Q000276:immunology; D001284:Atrophy; D002060:Bursa of Fabricius / Q000473:pathology; D002645:Chickens; D006130:Growth Disorders / Q000473:pathology / Q000662:veterinary* / Q000821:virology; D009980:Influenza A virus / Q000276:immunology / Q000502:physiology*; D007668:Kidney / Q000276:immunology / Q000821:virology; D008099:Liver / Q000276:immunology / Q000821:virology; D008168:Lung / Q000276:immunology / Q000821:virology; D010179:Pancreas / Q000473:pathology; D010195:Pancreatitis / Q000209:etiology / Q000473:pathology / Q000662:veterinary; D011201:Poultry Diseases / Q000473:pathology / Q000503:physiopathology / Q000821:virology*; D012044:Regression Analysis; D013577:Syndrome; D013950:Thymus Gland / Q000473:pathology; D015430:Weight Gain / Q000502:physiology
chemical_list: D000956:Antigens, Viral