title: Distribution of HLA-A*28 alleles in a Spanish population.
abstract: DNA oligotyping was used to determine HLA-A28 subtypes in 25 unrelated Caucasian individuals living in or around Seville, Spain. Results showed that HLA-A*6802 was the most frequent allele, found in 14 individuals (53.8%), followed by HLA-68.3, which was present in eight subjects (30.8%), and both combined represented 84.6% of A28+ individuals in the area. The HLA-A*6801 allele was found in three individuals (11.5%), whereas HLA-A*6901 was present in one subject only (3.8%). Results indicate that the distribution of HLA-A28 alleles can vary among different Caucasoid populations. In this way, the high frequency obtained for A*6802 supports previous studies suggesting that the HLA-A*6802 allele was prevalent in people of the Mediterranean basin, in contrast to A*6801, prevalent in northern European populations.
authors.affiliation: Department of Immunology, University Hospital of the Virgin of Rocío, Seville, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Yélamos
authors.forename: M F
authors.initials: MF
authors.lastname: González
authors.forename: J R
authors.initials: JR
authors.lastname: García-Lozano
authors.forename: B
authors.initials: B
authors.lastname: Sánchez
mesh_terms: D000483:Alleles; D004247:DNA / Q000032:analysis; D005787:Gene Frequency; D015234:HLA-A Antigens / Q000235:genetics*; D006801:Humans; D013030:Spain
chemical_list: D015234:HLA-A Antigens; C037164:HLA-A28 antigen; D004247:DNA