title: (-)-Nicotine produces conditioned place preference in Lewis, but not Fischer 344 rats.
abstract: In this study, we sought to determine if Fischer 344 (F344) and Lewis rats showed different conditioned place preference (CPP) responses to subcutaneously administered (-)-nicotine. Lewis rats displayed a CPP response to (-)-nicotine after five pairings, whereas F344 rats showed no preference for nicotine compared to vehicle. After 10 pairings, the F344 rats showed a conditioned place aversion to (-)-nicotine, whereas the Lewis rats still displayed a significant CPP response. These results suggest that the differences in appetitiveness shown between Lewis and F344 rats to other drugs of abuse extend also to (-)-nicotine.
authors.affiliation: Department of Pharmaceutical Sciences, St. John's University, Jamaica, New York 11439, USA.
authors.forename: B
authors.initials: B
authors.lastname: Horan
authors.forename: M
authors.initials: M
authors.lastname: Smith
authors.forename: E L
authors.initials: EL
authors.lastname: Gardner
authors.forename: M
authors.initials: M
authors.lastname: Lepore
authors.forename: C R
authors.initials: CR
authors.lastname: Ashby
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D003213:Conditioning, Psychological / Q000187:drug effects*; D008297:Male; D009538:Nicotine / Q000494:pharmacology*; D051381:Rats; D011916:Rats, Inbred F344; D011917:Rats, Inbred Lew
chemical_list: D009538:Nicotine