[A new method for the comparative quantitative assessment of a radiomodifying effect].
A new criterion for the quantitative estimation of a radioprotective effect (radioprotector efficiency) is suggested. This is an integral index of protection. Biologically, this is an estimation of a proportion of animals survived, the survival rate in the experimental and control groups of exposed objects in the studied dose range. The methods of assessing the criterion, and its advantages over the commonly used dose reduction factor (DRF) are described. The efficiency of Cystamine, Naphthysin, Indralin, Thymogen, Lymphokinin, Prodigiosan, and Polyribonate are considered using the suggested criterion. A new method of a comparative estimation of the radioprotective effect is suggested.
Boĭko
V N
VN
Zholus
R B
RB
Legeza
V I
VI
D000818:Animals; D004307:Dose-Response Relationship, Radiation; D004353:Drug Evaluation, Preclinical; D005720:Gamma Rays; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D011833:Radiation Injuries, Experimental / Q000401:mortality / Q000517:prevention & control; D011837:Radiation-Protective Agents / Q000627:therapeutic use*; D012044:Regression Analysis
D011837:Radiation-Protective Agents
Novyĭ metod sravnitel'noĭ kolichestvennoĭ otsenki radiomodifitsiruiushchego éffekta.