[Immunomodulation after parenteral glutamine administration in colorectal surgery].
The influence of parenteral L-alanyl-L-glutamine dipeptide on the cysteinyl-leukotriene (cys-LT) synthesizing capacity from neutrophils was studied in patients undergoing colonic surgery. The decrease in cys-LT, observed postoperatively, could be normalized with parenteral glutamine, while the cys-LT decrease persisted in controls. We conclude that the provision of glutamine in the postoperative state improves normalization of neutrophil functions (e.g., generation of cys-LT), which is an essential prerequisite for host defences.
Morlion
B J
BJ
Klinik für Anästhesiologie und operative Intensivmedizin, Ruhr-Universität Bochum.
Siedhoff
H P
HP
Joosten
U
U
Köller
M
M
König
W
W
Fürst
P
P
Puchstein
C
C
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003110:Colonic Neoplasms / Q000276:immunology / Q000601:surgery*; D004151:Dipeptides / Q000008:administration & dosage*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D015289:Leukotrienes / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000276:immunology*; D010289:Parenteral Nutrition, Total; D011183:Postoperative Complications / Q000276:immunology*
D004151:Dipeptides; D015289:Leukotrienes; C054122:alanylglutamine
Immunmodulation nach parenteraler Glutaminzufuhr in der Dickdarmchirurgie.