title: The nature of spatiotemporal changes in cerebral hemodynamics as manifested in functional magnetic resonance imaging.
abstract: The nature of changes in rapidly acquired magnetic resonance images of the brain was studied by using a denoising method and spectral techniques optimally suited to short time series. It was found that the stimulus related changes have a complex spatiotemporal structure even for simple visual stimuli. Apart from a low frequency window, the non-stimulus-related changes were found to correspond in detail to either breathing or heartbeat, although these two sources show different patterns of spatial coherence in the image. At low frequencies, oscillations with frequencies around 0.1 Hz were observed, also with nontrivial space-time structure, which are likely to be vasomotor in origin.
authors.affiliation: Bell Laboratories, Lucent Technologies, Murray Hill, New Jersey 07974, USA.
authors.forename: P P
authors.initials: PP
authors.lastname: Mitra
authors.forename: S
authors.initials: S
authors.lastname: Ogawa
authors.forename: X
authors.initials: X
authors.lastname: Hu
authors.forename: K
authors.initials: K
authors.lastname: Uğurbil
mesh_terms: D001808:Blood Vessels / Q000502:physiology; D001921:Brain / Q000098:blood supply / Q000502:physiology*; D002560:Cerebrovascular Circulation; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D010775:Photic Stimulation