[Functional reserve of the exocrine pancreas in Sjögren's syndrome].
Exocrine pancreatic function was studied in a homogeneous group of 33 female patients aged 42-67 years. Of these patients, 11 were classified as rheumatoid arthritis (RA), 11 as Sjögren's syndrome I (SSI) and 11 as Sjögren's syndrome associated with RA (SSII). Clinical features, laboratory tests and special instrumental techniques excluded gastroenteric-hepatobiliary causes of pancreatic diseases. These patients were subjected to direct pancreatic stimulation with secretin and caerulein (S. Cae test). Test results, compared to control-group (10 voluntary healthy females) showed, in the last 30 m of stimulation, a statistically significant decrease (p < 0.05) in duodenal juice volume, bicarbonates and trypsin in 6 cases (54.5%) of SSI and in 3 cases (27.2%) of RA. SSII S. Cae test showed a decrease of volume and bicarbonates in 6 patients (54.5%) and in only 4 of these (36.4%) it was associated with a concomitant decrease in trypsin levels. Authors discuss the subclinical exocrine pancreatic function in relationship to sicca-syndrome, possible immunological factors and primary disease of pancreatic ducts.
D'Ambrosi
A
A
Istituto di Medicina Interna I, Università, Ferrara.
Verzola
A
A
Gennaro
P
P
Gatto
S
S
Catellani
M
M
La Corte
R
R
D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology; D001639:Bicarbonates / Q000097:blood; D002108:Ceruletide; D010188:Exocrine Pancreatic Insufficiency / Q000175:diagnosis / Q000209:etiology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D010179:Pancreas / Q000503:physiopathology*; D010186:Pancreatic Function Tests; D012633:Secretin; D012859:Sjogren's Syndrome / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology*; D014357:Trypsin / Q000097:blood
D001639:Bicarbonates; D012633:Secretin; D002108:Ceruletide; D014357:Trypsin
La riserva funzionale del pancreas esocrino in corso di sindrome di Sjögren.