Pregnancy rates using CC/hMG or hMG alone.
OBJECTIVE
The purpose of our study was to determine which of the two drug regimens is more successful in achieving conception in the infertile couple.


METHODS
One hundred and sixty women with primary infertility were included in this study. Group A, consisted of 102 patients were treated with clomiphene citrate (CC) and human menopausal gonadotrophin (hMG). Group B, consisted of 58 patients were treated with hMG alone.


METHODS
This retrospective study was performed between April 1993 and March 1996, to compare the pregnancy rates in women using two drug regimens with ultrasound scan and serum E2 to monitor ovulation induction.


RESULTS
The pregnancy rate per patient in Group A was significantly higher than in Group B (46% vs 25.9%) as was the pregnancy rate per treatment cycle (31.3% vs 15.8%) pregnancy loss was lower in Group A than in Group B (17% vs 33.3%). The incidence of multiple pregnancy was 8.5% in Group A, and 13.3% in Group B. While the incidence of ovarian hyperstimulation syndrome was 3% in Group A, and 6.9% in Group B.


CONCLUSIONS
We concluded that the use of CC + hMG in an assisted conception programme gives a better pregnancy rate 46% than in the hMG alone 25.9%. These data with the use of U/S scan and serum E2 clearly showed that the use of CC + hMG is a successful and safe method for the treatment of infertile patients.
Ziadeh
S M
SM
Department of Obstetrics and Gynaecology, Jordan University of Science and Technology, Irbid, Jordan.
Zakaria
M R
MR
Abu-Hieja
A
A
D000328:Adult; D002996:Clomiphene / Q000008:administration & dosage / Q000494:pharmacology*; D004359:Drug Therapy, Combination; D004967:Estrogens / Q000097:blood; D005260:Female; D005298:Fertility / Q000187:drug effects* / Q000502:physiology; D005300:Fertility Agents, Female / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D015994:Incidence; D007275:Injections, Intravenous; D007597:Jordan / Q000453:epidemiology; D008596:Menotropins / Q000008:administration & dosage / Q000494:pharmacology*; D016471:Ovarian Hyperstimulation Syndrome / Q000453:epidemiology; D010060:Ovulation / Q000187:drug effects*; D010062:Ovulation Induction / Q000379:methods; D011247:Pregnancy; D018873:Pregnancy Rate; D012189:Retrospective Studies
D004967:Estrogens; D005300:Fertility Agents, Female; D002996:Clomiphene; D008596:Menotropins