title: Clinical evaluation of tetracycline HCl conditioning in the treatment of gingival recessions. A comparative study.
abstract: Thirty Class I and Class II recessions in 30 patients were treated with a modified subepithelial connective tissue graft procedure. Fifteen recessions in the test group received a tetracycline hydrochloride (50 mg/ml) root treatment for 5 minutes (TTC-HCl group); the remaining 15 recessions composed the control group and received a citric acid root treatment for 3 minutes (CA group). Clinical assessments were taken at baseline and at 6 months. The differences between treatments were not statistically significant. In the central area of the recession, the mean percentage of root coverage was 81.7% corresponding to a mean percentage of 79.3% and 84.0% for the TTC-HCl and the CA group, respectively. In the test group, 6 of the 15 recessions exhibited complete root coverage; the gingival augmentation was 57.8%. In the control group, 8 of the 15 recessions exhibited complete root coverage; the gingival augmentation was 43.6%. The mean surface area of root exposure was reduced from 11.53 mm2 and 13.30 mm2 to 0.34 mm2 and 0.29 mm2 for the TTC-HCl group and the CA group, respectively. This reduction corresponds to a mean percentage of 97.4% root coverage for both groups. Within the limits of this study, the results indicate that tetracycline hydrochloride and citric acid root conditioning have comparable clinical effects in root coverage surgical therapy. The data also suggest that the measurement of the surface area of the recession is a more accurate criterion in the evaluation of the mean percentage of root coverage than a single central vertical linear measurement.
authors.affiliation: Department of Periodontology, School of Dentistry, Paris University, France.
authors.forename: P
authors.initials: P
authors.lastname: Bouchard
authors.forename: R
authors.initials: R
authors.lastname: Nilveus
authors.forename: D
authors.initials: D
authors.lastname: Etienne
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D019343:Citric Acid / Q000008:administration & dosage / Q000627:therapeutic use; D003131:Combined Modality Therapy; D003238:Connective Tissue / Q000637:transplantation; D005260:Female; D005881:Gingiva / Q000187:drug effects / Q000473:pathology; D005888:Gingival Pocket / Q000188:drug therapy / Q000473:pathology / Q000601:surgery; D005889:Gingival Recession / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D013524:Surgical Flaps / Q000379:methods; D013752:Tetracycline / Q000008:administration & dosage / Q000627:therapeutic use*; D014092:Tooth Root / Q000187:drug effects / Q000473:pathology
chemical_list: D000900:Anti-Bacterial Agents; D019343:Citric Acid; D013752:Tetracycline