title: Antidepressants in panic disorder.
abstract: Antidepressants have been used to treat patients with panic disorder almost since these drugs were first introduced. Tricyclic antidepressants, monoamine oxidase inhibitors (MAOIs), serotonin selective reuptake inhibitors (SSRIs), and other antidepressants have all been studied, with varying results, in patients with panic disorder. The MAOIs are believed by some clinicians to be the most potent anti-panic agents, but their considerable side effects limit their use. The tricyclic antidepressants imipramine and clomipramine are well established in treating panic disorder, although today many clinicians choose an SSRI as their first-line agent. Data supporting this clinical preference for SSRIs are just now becoming available.
authors.affiliation: Department of Psychiatry, University of Wisconsin Medical School, Madison, USA.
authors.forename: J W
authors.initials: JW
authors.lastname: Jefferson
mesh_terms: D000928:Antidepressive Agents / Q000627:therapeutic use*; D000929:Antidepressive Agents, Tricyclic / Q000627:therapeutic use; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D006801:Humans; D007099:Imipramine / Q000627:therapeutic use; D008996:Monoamine Oxidase Inhibitors / Q000627:therapeutic use; D016584:Panic Disorder / Q000188:drug therapy*; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D000928:Antidepressive Agents; D000929:Antidepressive Agents, Tricyclic; D007099:Imipramine; D008996:Monoamine Oxidase Inhibitors; D017367:Selective Serotonin Reuptake Inhibitors