title: Exhaustive physical exercise increases frequency of micronuclei.
abstract: Micronucleus (MN) tests were performed on PHA-stimulated blood lymphocytes of six healthy volunteers before and after two exhaustive sprints, causing lactate concentrations in the peripheral blood between 9.6 and 12.4 mmol/l. The number of micronuclei was significantly increased after 24-48 h in all six subjects. The mean of the total group increased from 37 MN per 3000 binucleated cells before exercise to 56 and 55 MN 24 and 48 h after exercise, respectively. These differences were also significant. These results indicate that exhaustive physical exercise causes severe mutations at the chromosome level in blood lymphocytes.
authors.affiliation: Department of Human Biology and Human Genetics, University of Kaiserslautern, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Schiffl
authors.forename: C
authors.initials: C
authors.lastname: Zieres
authors.forename: H
authors.initials: H
authors.lastname: Zankl
mesh_terms: D000328:Adult; D002478:Cells, Cultured; D015444:Exercise; D005260:Female; D006801:Humans; D007773:Lactates / Q000097:blood; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000166:cytology / Q000502:physiology*; D008297:Male; D048629:Micronuclei, Chromosome-Defective / Q000502:physiology* / Q000648:ultrastructure; D015162:Micronucleus Tests; D005082:Physical Exertion; D012420:Running; D012907:Smoking
chemical_list: D007773:Lactates