title: Triterpene saponins from Cyclamen mirabile and their biological activities.
abstract: Six saponins, cyclaminorin (1), deglucocyclamin (2), cyclacoumin (3), cyclamin (4), isocyclamin (5), and mirabilin (6) were isolated from the tubers of Cyclamen mirabile. Compound 6 is a new natural compound, and its structure was established as 3-[O-beta-[[beta-D-xylopyranosyl-(1-->2)]- [beta-D-glycopyranosyl-(1-->6)]-beta-D-glucopyranosyl-(1-->4)]-[be ta-D- glucopyranosyl-(1-->2)]-alpha-L-arabinopyranosyl]-3 beta,16 alpha,28-trihydroxyolean-12-en-30-oic acid (6). The structure elucidation of this compound was accomplished using both spectral and chemical methods. Antimicrobial and uterocontractile activities of the saponins were also investigated.
authors.affiliation: Department of Pharmacognosy, Hacettepe University, Faculty of Pharmacy, Ankara, Turkey.
authors.forename: T
authors.initials: T
authors.lastname: Caliş
authors.forename: M E
authors.initials: ME
authors.lastname: Satana
authors.forename: A
authors.initials: A
authors.lastname: Yürüker
authors.forename: P
authors.initials: P
authors.lastname: Kelican
authors.forename: R
authors.initials: R
authors.lastname: Demirdamar
authors.forename: R
authors.initials: R
authors.lastname: Alaçam
authors.forename: N
authors.initials: N
authors.lastname: Tanker
authors.forename: H
authors.initials: H
authors.lastname: Rüegger
authors.forename: O
authors.initials: O
authors.lastname: Sticher
mesh_terms: D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D000900:Anti-Bacterial Agents / Q000302:isolation & purification* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D005260:Female; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D009828:Oleanolic Acid / Q000031:analogs & derivatives*; D018517:Plant Roots / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D012503:Saponins / Q000302:isolation & purification* / Q000494:pharmacology; D016339:Spectrometry, Mass, Fast Atom Bombardment; D014315:Triterpenes / Q000302:isolation & purification* / Q000494:pharmacology; D014590:Uterine Contraction / Q000187:drug effects*
chemical_list: D000900:Anti-Bacterial Agents; D012503:Saponins; D014315:Triterpenes; C105644:mirabilin; D009828:Oleanolic Acid; D000109:Acetylcholine