Effect of long-term 'corn peptide' ingestion on alcohol metabolism in stroke-prone spontaneously hypertensive rats with alcohol loading.
The effect of long-term 'corn peptide (CP)' ingestion on alcohol metabolism was investigated in stroke-prone spontaneously hypertensive rats (SHR-SP) with alcohol loading. Long-term CP ingestion in the EtOH/CP group did not significantly increase plasma GOT and GPT activities but markedly increased hepatic ADH and ALDH activities. Intragastric CP administration prior to a dose of 1.0 g/kg ethanol significantly lowered the blood ethanol concentration in SHR-SP which had been loaded with ethanol for a long time. Compared with non-loaded SHR-SP (control group), the rats loaded for a long time with ethanol (EtOH group) showed high concentrations of taurine, glycine and histidine in the plasma. The plasma threonine and proline concentrations were significantly elevated by long-term CP ingestion (EtOH/CP group), but the plasma alanine concentration was rather decreased. These results suggest that short- or long-term CP ingestion may enhance the alcohol metabolism within the body because of an increase in ADH and ALDH activities as well as the alleviation of alcohol-related hepatic injury.
Yamaguchi
M
M
Research Institute, Nihon Shokuhin Kako Co., Ltd., Fuji, Japan.
Nishikiori
F
F
Nozaki
O
O
Ito
M
M
Furukawa
Y
Y
D000079:Acetaldehyde / Q000097:blood; D000410:Alanine Transaminase / Q000097:blood; D000426:Alcohol Dehydrogenase / Q000378:metabolism; D000444:Aldehyde Dehydrogenase / Q000378:metabolism; D000596:Amino Acids / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001835:Body Weight; D004044:Dietary Proteins / Q000008:administration & dosage*; D000431:Ethanol / Q000008:administration & dosage / Q000378:metabolism*; D006973:Hypertension / Q000201:enzymology / Q000378:metabolism*; D008099:Liver / Q000201:enzymology; D008297:Male; D009042:Motivation; D051381:Rats; D011918:Rats, Inbred SHR; D003313:Zea mays
D000596:Amino Acids; D004044:Dietary Proteins; D000431:Ethanol; D000426:Alcohol Dehydrogenase; D000444:Aldehyde Dehydrogenase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000079:Acetaldehyde