Chromosome translocation-mediated conversion of a tumor suppressor gene into a dominant oncogene: fusion of EWS1 to WT1 in desmoplastic small round cell tumors.
Rauscher
F J
FJ
Wistar Institute, Philadelphia, PA 19104, USA. rauscher@wista.wistar.upenn.edu
D000293:Adolescent; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D004268:DNA-Binding Proteins / Q000235:genetics* / Q000502:physiology; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D016162:Genes, Wilms Tumor; D034441:Heterogeneous-Nuclear Ribonucleoproteins; D006801:Humans; D008297:Male; D008957:Models, Genetic; D015514:Oncogene Proteins, Fusion / Q000235:genetics* / Q000502:physiology; D009857:Oncogenes; D012261:Ribonucleoproteins / Q000235:genetics* / Q000502:physiology; D012512:Sarcoma, Ewing / Q000235:genetics / Q000473:pathology; D018228:Sarcoma, Small Cell / Q000235:genetics* / Q000473:pathology; D014157:Transcription Factors / Q000235:genetics* / Q000502:physiology; D014178:Translocation, Genetic; D025721:WT1 Proteins; D016335:Zinc Fingers / Q000235:genetics / Q000502:physiology
D004268:DNA-Binding Proteins; C106032:EWS1-WT1 fusion protein, human; D034441:Heterogeneous-Nuclear Ribonucleoproteins; D015514:Oncogene Proteins, Fusion; D012261:Ribonucleoproteins; D014157:Transcription Factors; D025721:WT1 Proteins