title: Purine metabolism in HIV-1 virus-infected T lymphocyte population.
abstract: Purine nucleotide metabolism has been studied in T-lymphocyte population in healthy subjects and in AIDS bearing patients. Nucleotide content was determined by HPLC. The overall rate of purine nucleotide synthesis was measured following the incorporation of 14C-formate into the nucleotides of a T cell suspension. The authors discuss the results, which indicate interesting variations in nucleotide content and a lower nucleotide synthesis, determined by kinetic studies.
authors.affiliation: Istituto di Biochimica e di Enzimologia, Siena, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Carlucci
authors.forename: A
authors.initials: A
authors.lastname: Tabucchi
authors.forename: D
authors.initials: D
authors.lastname: Perrett
authors.forename: M
authors.initials: M
authors.lastname: Pizzichini
authors.forename: F
authors.initials: F
authors.lastname: Rosi
authors.forename: R
authors.initials: R
authors.lastname: Pagani
authors.forename: E
authors.initials: E
authors.lastname: Marinello
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000378:metabolism*; D000328:Adult; D002851:Chromatography, High Pressure Liquid; D005260:Female; D015658:HIV Infections / Q000378:metabolism; D015497:HIV-1; D006801:Humans; D008297:Male; D008875:Middle Aged; D011685:Purine Nucleotides / Q000378:metabolism*; D013601:T-Lymphocytes / Q000378:metabolism*
chemical_list: D011685:Purine Nucleotides