In-vivo activity and tolerance of conventional formulation versus fat emulsion formulation of amphotericin B in experimental disseminated candidiasis in neutropenic rabbits.
Amphotericin B can cause significant toxicity but this can be reduced by direct dilution into a fat emulsion (Intralipid). To investigate the potential use of amphotericin B diluted in Intralipid, a study was made of its activity in the treatment of subacute disseminated candidiasis in persistently granulocytopenic rabbits, compared with the same dose of amphotericin B diluted in dextrose. Amphotericin-B-fat emulsion was at least as effective as amphotericin-B-dextrose. Amphotericin-B-fat emulsion was significantly more effective than amphotericin-B-dextrose therapy in reducing candida colony counts in both kidney and liver tissues (P < 0.05). Furthermore, amphotericin-B-fat emulsion was found less toxic on the renal function than conventional amphotericin B (P < 0.05). From these experimental results, we conclude that amphotericin-B-fat emulsion (Intralipid) was at least as effective and less toxic than conventional amphotericin B.
Chavanet
P
P
Infectious Diseases Department, Hopital du Bocage, Dijon, France.
Duong
M
M
Buisson
M
M
Hamel
H
H
Dubois
C
C
Bonnin
A
A
Portier
H
H
D000666:Amphotericin B / Q000008:administration & dosage* / Q000627:therapeutic use / Q000633:toxicity; D000818:Animals; D002177:Candidiasis / Q000150:complications / Q000188:drug therapy*; D003404:Creatinine / Q000097:blood; D005217:Fat Emulsions, Intravenous; D005947:Glucose; D007668:Kidney / Q000187:drug effects; D008297:Male; D009503:Neutropenia / Q000150:complications / Q000503:physiopathology*; D011817:Rabbits; D014508:Urea / Q000097:blood
D005217:Fat Emulsions, Intravenous; D000666:Amphotericin B; D014508:Urea; D003404:Creatinine; D005947:Glucose