title: Cranial bone grafting: biodegradable versus titanium fixation in a rabbit model.
abstract: Rigid internal fixation with miniplates and screws has enabled reconstructive surgeons to position bony segments precisely. Unfortunately, our present systems have been associated with a potential adverse effect on ultimate craniofacial growth and development. Also, they may be palpable, necessitating secondary procedures for removal of the hardware. We have been involved in an ongoing study evaluating the efficacy of a commercially developed biodegradable system. In this study, we compared biodegradable lag screw fixation with traditional titanium screw fixation in full-thickness, membranous bone grafts harvested from the zygomatic arches to the snout in a rabbit model. The results were compared with standard hematoxylin and eosin stains and laser densometry. Although this study adds further credence to the resorption of bone grafts, those secured with the polyglycolic acid screws demonstrated significantly less resorption than those maintained in position by traditional methods.
authors.affiliation: Department of Surgery, University of Miami, Florida 33101, USA.
authors.forename: S R
authors.initials: SR
authors.lastname: Thaller
authors.forename: C
authors.initials: C
authors.lastname: Moore
authors.forename: H
authors.initials: H
authors.lastname: Tesluk
authors.forename: R
authors.initials: R
authors.lastname: Holmes
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D001673:Biodegradation, Environmental; D001863:Bone Screws; D016025:Bone Transplantation / Q000295:instrumentation*; D008297:Male; D011100:Polyglycolic Acid; D011817:Rabbits; D012886:Skull / Q000601:surgery*; D014025:Titanium
chemical_list: D001672:Biocompatible Materials; D011100:Polyglycolic Acid; D014025:Titanium