Effects of continuous venovenous hemofiltration on cardiopulmonary function in a porcine model of endotoxin-induced shock.
OBJECTIVE
To determine whether continuous venovenous hemofiltration, proposed to remove inflammatory mediators from circulation, would resolve cardiopulmonary derangements in a model of established endotoxic shock.


METHODS
16 clinically normal pigs.


METHODS
Endotoxin was infused, IV, into anesthetized pigs for a total of 50 minutes. Thirty minutes after termination of the infusion period, extracorporeal circulation was initiated through a 50-kd diafilter, or past the filter without ultrafiltrate formation. Cardiac and respiratory variables were monitored for a period of 4 hours.


RESULTS
Infusion of lipopolysaccharide resulted in a severe hypodynamic circulatory state, with significant decreases in mean arterial pressure and cardiac output concurrent with a significant increase in pulmonary arterial pressure. Hemofiltration was not associated with any correction of lipopolysaccharide-induced cardiopulmonary derangements.


CONCLUSIONS
Continuous venovenous hemofiltration, as used in this acute experiment, did not improve cardiopulmonary dysfunction during endotoxic shock.


CONCLUSIONS
Continuous venovenous hemofiltration needs further investigation before it can be recommended as a clinically effective treatment.
Murphey
E D
ED
Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Purdue University, West Lafayette, IN 47907, USA.
Fessler
J F
JF
Bottoms
G D
GD
Latshaw
H
H
Johnson
M
M
Mueller
B
B
Clark
W
W
Macias
W
W
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D002302:Cardiac Output / Q000187:drug effects / Q000502:physiology; D002319:Cardiovascular System / Q000187:drug effects / Q000503:physiopathology*; D004195:Disease Models, Animal; D005260:Female; D006440:Hemofiltration / Q000379:methods / Q000662:veterinary*; D008070:Lipopolysaccharides / Q000494:pharmacology; D008170:Lung Compliance / Q000187:drug effects / Q000502:physiology; D008297:Male; D010313:Partial Pressure; D011669:Pulmonary Wedge Pressure / Q000187:drug effects / Q000502:physiology; D012137:Respiratory System / Q000187:drug effects / Q000503:physiopathology*; D012772:Shock, Septic / Q000503:physiopathology / Q000628:therapy / Q000662:veterinary*; D013552:Swine; D013553:Swine Diseases / Q000139:chemically induced / Q000503:physiopathology* / Q000628:therapy; D013997:Time Factors
D008070:Lipopolysaccharides