Effect of glucagon on renal excretion of oxypurinol and purine bases.
OBJECTIVE
To investigate whether glucagon increases the urinary excretion of oxypurinol and purine bases.


METHODS
We administered 1 mg glucagon intravenously to 5 healthy subjects taking 300 mg allopurinol orally, and determined plasma concentrations and urinary excretion of oxypurinol and purine bases.


RESULTS
Glucagon increased the urinary excretion and fractional clearances of uric acid, xanthine, and oxypurinol, together with an increase in creatinine clearance, while it decreased plasma concentrations of xanthine and hypoxanthine.


CONCLUSIONS
Glucagon-induced increases in urinary excretion of uric acid, xanthine, and oxypurinol were attributable to increases in the fractional clearances of uric acid, xanthine, and oxypurinol in addition to an increase in glomerular filtration rate. It is suggested that glucagon affects the renal common transport pathway of uric acid, xanthine, and oxypurinol by stimulating the release of a liver derived renal vasodilator.
Yamamoto
T
T
Third Department of Internal Medicine, Hyogo College of Medicine, Japan.
Moriwaki
Y
Y
Takahashi
S
S
Tsutsumi
Z
Z
Hiroishi
K
K
Yamakita
J
J
Nakano
T
T
Higashino
K
K
D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D002713:Chlorine / Q000097:blood; D003404:Creatinine / Q000378:metabolism; D000242:Cyclic AMP / Q000097:blood; D005934:Glucagon / Q000494:pharmacology*; D006801:Humans; D019271:Hypoxanthine / Q000097:blood / Q000652:urine; D007668:Kidney / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D009584:Nitrogen / Q000097:blood; D010117:Oxypurinol / Q000097:blood / Q000652:urine*; D010710:Phosphates / Q000097:blood; D011688:Purinones / Q000097:blood / Q000652:urine*; D012964:Sodium / Q000097:blood; D014527:Uric Acid / Q000097:blood / Q000652:urine; D019820:Xanthine; D014970:Xanthines / Q000097:blood / Q000652:urine
D001786:Blood Glucose; D010710:Phosphates; D011688:Purinones; D014970:Xanthines; D019820:Xanthine; D014527:Uric Acid; D019271:Hypoxanthine; D002713:Chlorine; D005934:Glucagon; D012964:Sodium; D003404:Creatinine; D000242:Cyclic AMP; D010117:Oxypurinol; D009584:Nitrogen