title: Incidence of chromosomal abnormalities in 153 pregnancies with ultrasound detected fetal abnormalities.
abstract: One hundred and fifty-three patients with fetal abnormalities diagnosed on ultrasound were karyotyped between January 1992 and December 1993. There were 19 (12.4%) fetuses with chromosomal abnormalities. The risk of chromosomal aberrations in the malformed fetuses were increased in the presence of intrauterine growth retardation (15.4%), oligohydramnios (20%) and polyhydramnios (25%). Fetal karyotyping is thus essential in the management of such pregnancies.
authors.affiliation: Department of Obstetrics & Gynaecology, National University Hospital, Singapore.
authors.forename: S
authors.initials: S
authors.lastname: Chew
authors.forename: C
authors.initials: C
authors.lastname: Anandakumar
authors.forename: V
authors.initials: V
authors.lastname: Jayanthi
authors.forename: Y C
authors.initials: YC
authors.lastname: Wong
authors.forename: D
authors.initials: D
authors.lastname: Chia
authors.forename: S
authors.initials: S
authors.lastname: Arulkumaran
authors.forename: S S
authors.initials: SS
authors.lastname: Ratnam
mesh_terms: D002869:Chromosome Aberrations / Q000000981:diagnostic imaging*; D025063:Chromosome Disorders; D000013:Congenital Abnormalities / Q000000981:diagnostic imaging* / Q000196:embryology / Q000235:genetics; D005260:Female; D005315:Fetal Diseases / Q000000981:diagnostic imaging* / Q000235:genetics; D005317:Fetal Growth Retardation / Q000000981:diagnostic imaging; D006801:Humans; D007621:Karyotyping; D016104:Oligohydramnios / Q000000981:diagnostic imaging; D006831:Polyhydramnios / Q000000981:diagnostic imaging; D011247:Pregnancy; D012189:Retrospective Studies; D016216:Ultrasonography, Prenatal