Plasma selectin levels in patients with Graves' disease.
Adhesion molecules relate to cell invasion of autoimmune thyroid disease. We studied plasma soluble P-Selectin (platelet activation-dependent granule-external membrane protein), E-Selectin (endothelial leukocyte adhesion molecule) and L-Selectin (leukocyte endothelial cell adhesion molecule-1) levels in patients with Graves' disease before and during methimazole treatment. Plasma P-, E- and L-Selectin levels in patients with untreated Graves' disease were significantly higher than those in normal subjects. Plasma P-Selectin levels decreased when their thyroid functions were normal for more than 6 months after the start of methimazole treatment. No significant change in plasma E- and L-Selectin levels in patients with Graves' disease was found between hyperthyroid state and euthyroid state after the start of methimazole treatment, but plasma L-Selectin levels in patients with untreated Graves' disease were significantly lower than those in the patients in the first euthyroid state. There was no significant correlation between plasma P-Selectin levels and serum FT4 levels, nor between plasma P-Selectin levels and serum FT3 levels. These results suggested that thyroid hormones might reflect expression of P-, L- and E-Selectin from endothelial cells, or lymphocytes, or platelets in patients with Graves' disease.
Hara
H
H
3rd Department of Internal Medicine, Showa University School of Medicine, Tokyo, Japan.
Sugita
E
E
Sato
R
R
Ban
Y
Y
D000328:Adult; D013956:Antithyroid Agents / Q000627:therapeutic use; D001323:Autoantibodies / Q000097:blood; D019040:E-Selectin / Q000097:blood*; D005260:Female; D006111:Graves Disease / Q000097:blood* / Q000188:drug therapy; D006801:Humans; D019041:L-Selectin / Q000097:blood*; D008297:Male; D008713:Methimazole / Q000627:therapeutic use; D008875:Middle Aged; D019007:P-Selectin / Q000097:blood*; D011989:Receptors, Thyrotropin / Q000276:immunology; D013968:Thyroiditis, Subacute / Q000097:blood; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
D013956:Antithyroid Agents; D001323:Autoantibodies; D019040:E-Selectin; D019007:P-Selectin; D011989:Receptors, Thyrotropin; D014284:Triiodothyronine; D019041:L-Selectin; D008713:Methimazole; D013972:Thyrotropin; D013974:Thyroxine