Liposomes for drug targeting in the lymphatic system.
Suspensions, emulsions, solutions, and liposomes were used as carriers to deliver drugs endolymphatically in animals. The purpose was to find which preparation was best tolerated by lymph tissue while slowly releasing the highly concentrated drugs out of nodal depots. Large unilamellar liposomes manufactured by detergent dialysis yielded the best results.
Hirnle
P
P
Department of Gynecology, University of Tübingen, Germany.
D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000627:therapeutic use; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000627:therapeutic use; D000935:Antifungal Agents / Q000008:administration & dosage / Q000627:therapeutic use; D052176:Azulenes; D001761:Bleomycin / Q000008:administration & dosage / Q000627:therapeutic use; D016503:Drug Delivery Systems / Q000379:methods*; D007459:Iodized Oil / Q000627:therapeutic use; D008081:Liposomes; D008206:Lymphatic Diseases / Q000188:drug therapy; D008208:Lymphatic System / Q000378:metabolism*; D012717:Sesquiterpenes / Q000008:administration & dosage / Q000627:therapeutic use; D045789:Sesquiterpenes, Guaiane
D000890:Anti-Infective Agents; D000903:Antibiotics, Antineoplastic; D000935:Antifungal Agents; D052176:Azulenes; D008081:Liposomes; D012717:Sesquiterpenes; D045789:Sesquiterpenes, Guaiane; D001761:Bleomycin; C004451:guaiazulene; D007459:Iodized Oil