Response of choriocarcinoma to paclitaxel. Case report and review of resistance.
Paclitaxel has been reported to inhibit proliferation and to promote differentiation of choriocarcinoma cells. We report a case of a patient with high risk trophoblastic disease who had remission with paclitaxel. The mechanisms of paclitaxel resistance are reviewed.
Gerson
R
R
Unidad de Quimioterapia, Hospital General de Mexico, Mexico, D.F.
Serrano
A
A
Del Carmen Bello
M
M
Lazaro
M
M
Kudelka
A P
AP
Kavanagh
J J
JJ
D000328:Adult; D000972:Antineoplastic Agents, Phytogenic / Q000627:therapeutic use*; D002822:Choriocarcinoma / Q000188:drug therapy*; D019008:Drug Resistance, Neoplasm; D005260:Female; D006801:Humans; D017239:Paclitaxel / Q000627:therapeutic use*; D011247:Pregnancy; D014328:Trophoblastic Neoplasms / Q000188:drug therapy*; D014594:Uterine Neoplasms / Q000188:drug therapy*
D000972:Antineoplastic Agents, Phytogenic; D017239:Paclitaxel