title: Agyria-pachygyria: cerebral perfusion studies by 99mTc-HMPAO SPECT [corrected].
abstract: Cerebral perfusion was investigated in three patients with agyria-pachygyria by using 99mTc-HMPAO SPECT in order to study the distribution of blood flow. Diffuse cortical hypoperfusion was found in all three infants. The visual cortex was not identifiable in two of the cases. The basal ganglia and cerebellum were prominent by their normal high activity, while tracer uptake was very low in the thalamus. The possible role of improper development of interneuronal connections and abnormal vascular pattern in background of the perfusion defect is discussed.
authors.affiliation: Department of Nuclear Medicine, Tawam Hospital, Al Ain, United Arab Emirates.
authors.forename: A R
authors.initials: AR
authors.lastname: al-Suhaili
authors.forename: L
authors.initials: L
authors.lastname: Sztriha
authors.forename: V
authors.initials: V
authors.lastname: Prais
authors.forename: M
authors.initials: M
authors.lastname: Nork
mesh_terms: D002540:Cerebral Cortex / Q000002:abnormalities* / Q000033:anatomy & histology / Q000098:blood supply; D002560:Cerebrovascular Circulation / Q000502:physiology*; D002675:Child, Preschool; D004569:Electroencephalography; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging; D008297:Male; D015609:Organotechnetium Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime; D015899:Tomography, Emission-Computed, Single-Photon; D014057:Tomography, X-Ray Computed
chemical_list: D015609:Organotechnetium Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime