Time course of manganese superoxide dismutase concentrations in serum of alcohol-dependent patients during abstinence.
Mean manganese superoxide dismutase (Mn-SOD) concentrations in the serum of patients suffering from alcohol dependence is almost twice as high as in serum of non-dependent controls. In order to investigate the time course of this parameter during abstinence, we determined it at different time points. Patients had mean Mn-SOD serum concentrations (+/-S.D.) of 150.4 +/- 76.3, 121.1 +/- 40.7, 94.6 +/- 37.8 micrograms/ml at 1, 10 and 40 days after abstinence compared to 76.3 +/- 16.9 micrograms/ml as mean Mn-SOD value in the control group. Although the Mn-SOD concentration tended to normalise during abstinence, the differences between index and control group remained significant up to the last measurement at day 40.
Thome
J
J
Department of Psychiatry, University of Würzburg, Germany.
Nara
K
K
Foley
P
P
Gsell
W
W
Wiesbeck
G A
GA
Böning
J
J
Riederer
P
P
D000328:Adult; D000437:Alcoholism / Q000201:enzymology / Q000534:rehabilitation*; D005260:Female; D005609:Free Radicals; D006801:Humans; D008297:Male; D010343:Patient Admission; D012016:Reference Values; D013482:Superoxide Dismutase / Q000097:blood*
D005609:Free Radicals; D013482:Superoxide Dismutase