title: Antisocial personality disorder and aggression in recently abstinent cocaine dependent subjects.
abstract: To study the relationship between cocaine abstinence symptoms, personality, and aggression, we used the Point Subtraction Aggression Paradigm (PSAP) to measure aggression in 18 subjects admitted for the treatment of cocaine dependence. Eight subjects met criteria for antisocial personality disorder (ASPD). There was a significant correlation between presence of ASPD and frequency of aggressive responding by stepwise multiple regression. When presence of ASPD was factored out of the correlations, there was no significant relationship between aggressive responding and cocaine craving, withdrawal symptoms, amount of cocaine used, or length of time since use. These preliminary results suggest that in cocaine dependent individuals seeking treatment, current aggression is most dependent on the individual's previous aggressive behavior.
authors.affiliation: Department of Psychiatry and Behavioral Sciences, University of Texas Houston Health Science Center, Harris County Psychiatric Center 77021, USA.
authors.forename: F G
authors.initials: FG
authors.lastname: Moeller
authors.forename: D M
authors.initials: DM
authors.lastname: Dougherty
authors.forename: T
authors.initials: T
authors.lastname: Rustin
authors.forename: A C
authors.initials: AC
authors.lastname: Swann
authors.forename: T J
authors.initials: TJ
authors.lastname: Allen
authors.forename: N
authors.initials: N
authors.lastname: Shah
authors.forename: D R
authors.initials: DR
authors.lastname: Cherek
mesh_terms: D000328:Adult; D000374:Aggression / Q000523:psychology*; D000987:Antisocial Personality Disorder / Q000175:diagnosis* / Q000523:psychology; D003042:Cocaine / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D010552:Personality Assessment; D013375:Substance Withdrawal Syndrome / Q000175:diagnosis* / Q000523:psychology; D019966:Substance-Related Disorders / Q000523:psychology / Q000534:rehabilitation*
chemical_list: D003042:Cocaine