title: [Cytokines in vaccines and interferon preparations].
abstract: Virus vaccines prepared on the basis of cells of mammals (rabies, poliomyelitis, measles and hepatitis A vaccines) contain cytokines (IL-1 beta, IL-6, TNF-alpha), whose concentration depends on the kind of the vaccine. Cell lines (green monkey kidney cells, VERO, 4647), used for the preparation of commercial and experimental vaccines, do not produce spontaneously any of the above cytokines. Cell line L-68, used for the manufacture of experimental measles vaccine, is capable of the spontaneous synthesis of IL-6. In Russian and foreign preparations of interferon the presence of IL-1 beta and TNF-alpha has been detected; the content of these cytokines is determined by the specific features of the methods used manufacturing these preparations.
authors.forename: S E
authors.initials: SE
authors.lastname: Akol'zina
authors.forename: Zh I
authors.initials: ZhI
authors.lastname: Avdeeva
authors.forename: M P
authors.initials: MP
authors.lastname: Potapnev
authors.forename: A V
authors.initials: AV
authors.lastname: Vozniuk
authors.forename: L V
authors.initials: LV
authors.lastname: Nevskaia
authors.forename: N A
authors.initials: NA
authors.lastname: Alpatova
authors.forename: G G
authors.initials: GG
authors.lastname: Ter-Gabriél'iants
authors.forename: N V
authors.initials: NV
authors.lastname: Medunitsyn
mesh_terms: D000818:Animals; D002460:Cell Line; D002478:Cells, Cultured; D006224:Cricetinae; D016207:Cytokines / Q000032:analysis*; D006507:Hepatovirus / Q000276:immunology; D007372:Interferons / Q000032:analysis*; D007375:Interleukin-1 / Q000032:analysis; D015850:Interleukin-6 / Q000032:analysis; D008458:Measles Vaccine / Q000032:analysis*; D011054:Poliovirus Vaccine, Inactivated / Q000032:analysis*; D011819:Rabies Vaccines / Q000032:analysis*; D011994:Recombinant Proteins / Q000032:analysis; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis; D014761:Viral Hepatitis Vaccines / Q000032:analysis*
chemical_list: D016207:Cytokines; D007375:Interleukin-1; D015850:Interleukin-6; D008458:Measles Vaccine; D011054:Poliovirus Vaccine, Inactivated; D011819:Rabies Vaccines; D011994:Recombinant Proteins; D014409:Tumor Necrosis Factor-alpha; D014761:Viral Hepatitis Vaccines; D007372:Interferons
vernacular_title: Tsitokiny v vaktsinakh i preparatakh interferona.