title: Cancer of the nasal cavity and paranasal sinuses. Prognosis and outcome of treatment.
abstract: A retrospective study of 121 patients, 77 men and 44 women, with sino-nasal cancer, admitted to the National University Hospital, Rigshospitalet, during the period 1983 1993, is presented. The median follow-up time was 21 months, (range 3 124). Forty-six percent of the tumors originated from the nasal cavity, 29% from the maxillary sinuses and 5% from the ethmoid sinuses. In 18% of the cases, the site of origin was not clear due to advanced local growth. Sixty-five patients received primary radiation therapy with curative intention of whom 5 underwent secondary surgery. Forty-nine patients underwent primary surgery, 38 of them received postoperative radiation therapy. The overall 5-year survival rate in this material was 35% and the disease-specific 5-year survival was 45%. Patients with well-differentiated squamous cell carcinomas had a significantly higher 5-year survival rate than patients with poorly differentiated carcinomas and patients with regional metastases had a significantly poorer 5-year survival than patients without. The 5-year local control was 48% (41/121). Six of 9 patients with regional metastases at admission were controlled locally, whereas 16 patients developed regional metastases after primary treatment.
authors.affiliation: Department of Otolaryngology, Head & Neck Surgery, National University Hospital, Rigshospitalet, Copenhagen, Denmark.
authors.forename: M H
authors.initials: MH
authors.lastname: Jakobsen
authors.forename: S K
authors.initials: SK
authors.lastname: Larsen
authors.forename: J
authors.initials: J
authors.lastname: Kirkegaard
authors.forename: H S
authors.initials: HS
authors.lastname: Hansen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma / Q000175:diagnosis / Q000628:therapy; D003131:Combined Modality Therapy; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000175:diagnosis / Q000628:therapy; D008297:Male; D008545:Melanoma / Q000175:diagnosis / Q000628:therapy; D008875:Middle Aged; D009669:Nose Neoplasms / Q000175:diagnosis* / Q000628:therapy*; D010255:Paranasal Sinus Neoplasms / Q000175:diagnosis* / Q000628:therapy*; D011379:Prognosis; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D016019:Survival Analysis; D016896:Treatment Outcome