title: Neuropsychological correlates of syndromes in schizophrenia.
abstract: BACKGROUND
  On the basis of Liddle's three-syndrome model of schizophrenia, it was predicted that: (1) symptoms of psychomotor poverty would be particularly correlated with impaired performance on neuropsychological tests likely to reflect functioning of the dorsolateral prefrontal cortex; (2) disorganisation would be particularly correlated with impaired performance on tests sensitive to medio-basal prefrontal functioning; and (3) reality distortion would be particularly correlated with measures sensitive to temporal lobe functioning.
  
  
  METHODS
  The above hypotheses were tested on 87 subjects with a confirmed diagnosis of schizophrenia. Patients' symptoms were scored for each of the three syndromes. Patients completed six neuropsychological tests designed to measure impairment in specific areas of the brain.
  
  
  RESULTS
  There was no support for the first two hypotheses. There was, however, evidence of a specific relationship between reality distortion and neuropsychological performance usually considered to be related to left temporal lobe functioning.
  
  
  CONCLUSIONS
  Although not directly supporting the first two hypotheses; the results are, in general, consistent with there being different cortical-subcortical circuits associated with each of psychomotor poverty and disorganisation. Temporal lobe functioning appears to have particular significance for the reality distortion syndrome.
authors.affiliation: London Health Sciences Centre, Ontario, Canada.
authors.forename: R M
authors.initials: RM
authors.lastname: Norman
authors.forename: A K
authors.initials: AK
authors.lastname: Malla
authors.forename: S L
authors.initials: SL
authors.lastname: Morrison-Stewart
authors.forename: E
authors.initials: E
authors.lastname: Helmes
authors.forename: P C
authors.initials: PC
authors.lastname: Williamson
authors.forename: J
authors.initials: J
authors.lastname: Thomas
authors.forename: L
authors.initials: L
authors.lastname: Cortese
mesh_terms: D000328:Adult; D001927:Brain Diseases / Q000523:psychology; D005260:Female; D005625:Frontal Lobe / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D017397:Prefrontal Cortex / Q000503:physiopathology; D011596:Psychomotor Disorders / Q000523:psychology*; D012565:Schizophrenic Psychology; D013577:Syndrome; D013702:Temporal Lobe / Q000503:physiopathology