Management and design of the maintenance of SAM mouse strains: an animal model for accelerated senescence and age-associated disorders.
The Senescence-Accelerated Mouse (SAM) was established by inbreeding and pedigree selection based on the life span, degree of senescence, as well as the incidence and degree of several age-associated disorders. At first, SAM strains were developed under conventional conditions, but now some strains are also maintained under specific pathogen-free conditions. There are many methods used to maintain such strains of mice; our methods will be introduced as one example of how to develop and maintain strains of mice used in aging research.
Hosokawa
M
M
Department of Senescence Biology, Kyoto University, Japan.
Abe
T
T
Higuchi
K
K
Shimakawa
K
K
Omori
Y
Y
Matsushita
T
T
Kogishi
K
K
Deguchi
E
E
Kishimoto
Y
Y
Yasuoka
K
K
Takeda
T
T
D000375:Aging / Q000235:genetics*; D000818:Animals; D005856:Germ-Free Life; D006799:Housing, Animal; D051379:Mice; D008815:Mice, Inbred Strains; D008954:Models, Biological; D010375:Pedigree; D012641:Selection, Genetic; D013997:Time Factors