Metabolic aspects of sleep apnea.
Sleep apnea is associated with abnormalities in metabolic function. First, there is a strong epidemiological link between central obesity and sleep apnea. Some evidence suggests that sleep apnea may promote weight gain or prevent weight loss by several mechanisms: reduction in anabolic (growth hormone and testosterone) hormone secretion, influences on energy balance and insulin sensitivity, and altered central serotonergic tone.
Grunstein
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Sleep Disorders Centre, Royal Prince Alfred Hospital, Camperdown, Sydney, Australia.
D004734:Energy Metabolism; D005260:Female; D013006:Growth Hormone / Q000172:deficiency; D013007:Growth Hormone-Releasing Hormone / Q000378:metabolism; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D008297:Male; D009765:Obesity / Q000150:complications; D011175:Positive-Pressure Respiration; D012737:Sex Factors; D012891:Sleep Apnea Syndromes / Q000209:etiology / Q000378:metabolism* / Q000628:therapy; D013739:Testosterone / Q000378:metabolism
D013739:Testosterone; D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone; D013007:Growth Hormone-Releasing Hormone