title: Single-stage stereotactic diagnosis and radiosurgery: feasibility and cost implications.
abstract: We compared the efficacy and the hospital charges of either single-stage or two-stage stereotactic diagnosis and radiosurgery procedures. Twelve patients underwent either one-stage or two-stage diagnosis and management of their brain tumors. Both techniques utilize high-resolution intraoperative stereotactic image-guided technology and rapid touch preparation (imprint) cytopathological techniques to confirm the presence of neoplasm. Following this pathologic diagnosis, six patients immediately underwent stereotactic radiosurgery employing the same frame application and dose planning based on preoperative and intraoperative images. Six patients underwent two-stage procedures, i.e., discharge from the hospital after histopathological diagnosis followed by readmission, reapplication of the stereotactic head frame, and repeat neuroradiological imaging prior to radiosurgery. Requirements for success of the single-stage procedure include intraoperative stereotactic high-resolution imaging, a hospital-wide ethernet system for transferring neurodiagnostic images, and expertise in rapid touch-preparation histopathological technique for accurate diagnosis. Intraoperative computed tomography imaging after biopsy confirmed the target accuracy and lack of movement of the target after brain biopsy. The advantages of the single-stage approach include reduced length of overall hospital stay, simultaneous histopathological diagnosis and therapy in a single hospital admission, and reduced total hospital charges. For patients highly suspected of having brain tumors and for whom stereotactic radiosurgery will be utilized in the treatment, single-stage stereotactic diagnosis immediately followed by radiosurgery is an accurate, effective, and potentially less costly management strategy than a two-stage approach.
authors.affiliation: Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pennsylvania, USA.
authors.forename: P C
authors.initials: PC
authors.lastname: Gerszten
authors.forename: L D
authors.initials: LD
authors.lastname: Lunsford
authors.forename: M J
authors.initials: MJ
authors.lastname: Rutigliano
authors.forename: D
authors.initials: D
authors.lastname: Kondziolka
authors.forename: J C
authors.initials: JC
authors.lastname: Flickinger
authors.forename: A J
authors.initials: AJ
authors.lastname: Martínez
mesh_terms: D000328:Adult; D000368:Aged; D001707:Biopsy, Needle / Q000191:economics / Q000379:methods*; D001932:Brain Neoplasms / Q000175:diagnosis / Q000191:economics / Q000601:surgery*; D003365:Costs and Cost Analysis; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D016634:Radiosurgery / Q000191:economics; D013238:Stereotaxic Techniques; D013813:Therapy, Computer-Assisted