title: [Diagnosis of renal tubular dysfunction in insulin-dependent diabetes mellitus].
abstract: Urinary levels of beta 2 microglobulin (beta 2 MG) and dipeptidipeptidse IV (DPP IV) were measured in 30 insulin dependent diabetes mellitus children aged 5 to 18 years. The control group consisted of 30 healthy children. Metabolic control (HbA1C) and the duration of diabetes were directly correlated with the levels of beta 2 MG and DPP IV. Beta 2 MG urinary levels were significantly increased in the diabetic group (MV = 0.340 +/- 0.076 mg/l) as compared with the controls (MV = 0.081 +/- 0.012 mg/l, p < 0.05). These values correlated only with the duration of diabetes and not with the HbA1C. DPP IV excretion was elevated in all diabetic patients (MV = 6.40 +/- 0.83 j/l). Significant correlations were not identified between urinary DPPIV excretion and the duration of diabetes and metabolic control.
authors.affiliation: Children's Hospital, Nish.
authors.forename: E
authors.initials: E
authors.lastname: Golubović
authors.forename: V
authors.initials: V
authors.lastname: Stefanović
authors.forename: S
authors.initials: S
authors.lastname: Zivić
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000503:physiopathology; D003928:Diabetic Nephropathies / Q000175:diagnosis* / Q000503:physiopathology; D018819:Dipeptidyl Peptidase 4 / Q000652:urine; D006801:Humans; D007684:Kidney Tubules / Q000503:physiopathology*; D001613:beta 2-Microglobulin / Q000652:urine
chemical_list: D001613:beta 2-Microglobulin; D018819:Dipeptidyl Peptidase 4
vernacular_title: Dijagnostika disfunkcije tubula bubrega u dijabetesu melitusu zavisnom od insulina.