Hepatitis GB virus C genome in the serum of aplastic anaemia patients receiving frequent blood transfusions.
GB virus C (GBV-C) RNA was detected in five of 18 patients with aplastic anaemia who had received blood transfusions, whereas it was not detected in eight patients who had not received any transfusions. Antibody against hepatitis C virus (anti-HCV) was detected in nine patients in the transfusion group, compared with one of eight who had not received any transfusions. Therefore, the route of transmission of both GBV-C and HCV in these patients appeared to have been multiple blood transfusion. Since all of the GBV-C RNA-positive patients harboured anti-HCV, GBV-C seems to frequently superinfect with HCV. Neither GBV-C nor HCV is likely to have been a causative agent of the anaemia in the cases examined.
Moriyama
K
K
Immunology Division, Jichi Medical School, Tochigi-Ken, Japan.
Okamura
T
T
Nakano
S
S
D000293:Adolescent; D000328:Adult; D000368:Aged; D000741:Anemia, Aplastic / Q000628:therapy* / Q000821:virology; D001803:Blood Transfusion; D005260:Female; D018067:Flaviviridae / Q000302:isolation & purification*; D006514:Hepatitis B Surface Antigens / Q000097:blood; D006526:Hepatitis C / Q000635:transmission; D018937:Hepatitis C Antibodies / Q000097:blood*; D006525:Hepatitis, Viral, Human / Q000635:transmission; D006801:Humans; D008297:Male; D008875:Middle Aged; D012367:RNA, Viral / Q000032:analysis; D065227:Transfusion Reaction
D006514:Hepatitis B Surface Antigens; D018937:Hepatitis C Antibodies; D012367:RNA, Viral