Impact of pregnancy and lactation on GABA(A) receptor and central-type and peripheral-type benzodiazepine receptors.
The effect of pregnancy and lactation on GABA(A) receptor and central- and peripheral-type benzodiazepine receptors (CBR and PBR, respectively) was studied in female Sprague-Dawley rats. Pregnancy was associated with increased CBR density (on day 19) in the hippocampus and with decreased [3H]Ro 15-1788-specific binding in the hypothalamus during pregnancy and lactation. A similar decrease in [3H]PK 11195-specific binding was observed in the hypothalamus and pituitary. An increase in PBR density in the ovary and uterus was observed during pregnancy, while adrenal PBR density was down-regulated during pregnancy and lactation. It seems that the hormonal changes occurring during pregnancy and lactation play a role in the regulation of CBR and PBR in discrete tissues.
Weizman
R
R
Tel Aviv Community Mental Health Center and Sackler Faculty of Medicine, Tel Aviv University, Israel.
Dagan
E
E
Snyder
S H
SH
Gavish
M
M
D000818:Animals; D002490:Central Nervous System / Q000378:metabolism*; D005260:Female; D005442:Flumazenil / Q000378:metabolism; D018757:GABA Modulators / Q000378:metabolism; D007546:Isoquinolines / Q000378:metabolism; D007774:Lactation / Q000378:metabolism*; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000378:metabolism*; D011388:Prolactin / Q000097:blood; D051381:Rats; D017207:Rats, Sprague-Dawley; D011963:Receptors, GABA-A / Q000145:classification* / Q000378:metabolism*; D014018:Tissue Distribution
D018757:GABA Modulators; D007546:Isoquinolines; D011963:Receptors, GABA-A; D005442:Flumazenil; D011388:Prolactin; C037850:PK 11195