Outer membrane proteins and elastase of Pseudomonas aeruginosa after the postantibiotic effect induced by amikacin.
Postantibiotic effects were induced in three Pseudomonas aeruginosa strains after short-term treatment (30 min) with amikacin at suprainhibitory concentrations in the range of 0.6-1.2 h (2 x MIC) and of 3.0-4.4 h (4 x MIC). Significant suppression of P. aeruginosa elastase activity was found after treatment with amikacin at 4 x MIC concentration (to 10-69.2% of the control values); 2 x MIC was less effective. The profile of outer membrane proteins of P. aeruginosa was not changed after treatment with amikacin at both concentrations.
Hostacká
A
A
Institute of Preventive and Clinical Medicine, Bratislava, Slovak Republic.
Karelová
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E
D000583:Amikacin / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001425:Bacterial Outer Membrane Proteins / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D008826:Microbial Sensitivity Tests; D010196:Pancreatic Elastase / Q000187:drug effects*; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000378:metabolism
D000900:Anti-Bacterial Agents; D001425:Bacterial Outer Membrane Proteins; D000583:Amikacin; D010196:Pancreatic Elastase