A case of infantile Dubin-Johnson syndrome with high CT attenuation in the liver.
We report a case of Dubin-Johnson syndrome (DJS) with severe infantile cholestasis and elevated computed tomography (CT) attenuation of the liver. Increased levels of urinary coproporphyrin I were found as well as pigment granules in the hepatocytes and hepatosteatosis. The CT attenuation was markedly higher in the liver of this patient at the ages of 3 and 7 months than in the spleen or kidneys. This high attenuation may be a finding specific to infantile DJS and, therefore, abdominal CT may be helpful in the diagnosis.
Shimizu
T
T
Department of Pediatrics, Juntendo University School of Medicine, 3-1-3, Hongo, Bunkyo-ku, Tokyo 113, Japan.
Tawa
T
T
Maruyama
T
T
Oguchi
S
S
Yamashiro
Y
Y
Yabuta
K
K
D001707:Biopsy, Needle; D003306:Coproporphyrins / Q000652:urine; D006801:Humans; D007223:Infant; D007566:Jaundice, Chronic Idiopathic / Q000175:diagnosis / Q000000981:diagnostic imaging*; D008099:Liver / Q000000981:diagnostic imaging* / Q000473:pathology; D008297:Male; D014057:Tomography, X-Ray Computed
D003306:Coproporphyrins; C031467:coproporphyrin I