[Opioid mechanisms of the analgesic action of cocaine].
Rat experiments revealed a dose-dependent and naloxone-dependent analgetic effect of cocaine (0.5-3.0 mg/kg), evaluated by the tail-flick test. The cocaine-sensitive animals were morphine-sensitive and the cocaine-insensitive ones were morphine-insensitive. In some cocaine-insensitive rats, the use of cocaine led to that the first phase characterized by the lack of changes in nociception was followed by a hyperalgesic phase. It is suggested that cocaine produces an analgetic effect mainly via the delta-opioid mechanism.
Litvinova
S V
SV
Aristova
V V
VV
Shul'goskiĭ
V V
VV
Meshcheriakov
A F
AF
Kaliuzhnyĭ
L V
LV
D000701:Analgesics, Opioid / Q000494:pharmacology*; D000818:Animals; D003042:Cocaine / Q000494:pharmacology*; D008297:Male; D010147:Pain Measurement; D051381:Rats; D017208:Rats, Wistar; D013696:Temperature
D000701:Analgesics, Opioid; D003042:Cocaine
Opioidnye mekhanizmy anal'geticheskogo deĭstviia kokaina.