title: Ontogeny of androgen receptor-like immunoreactivity in the reproductive tract of male Monodelphis domestica.
abstract: The distribution of nuclear androgen receptor-like immunoreactivity was studied in the reproductive tract of the developing and adult gray short-tailed Brazilian opossum (Monodelphis domestica), using the well-characterized rabbit polyclonal androgen receptor antibody, PG21. Androgen receptor-like immunoreactivity was first detected on the fifth day of postnatal age, in the mesenchymal tissues of the ductus deferens, gubernaculum testis, inguinal, and scrotal areas; the urogenital sinus; and the genital tubercle. Androgen receptor-like immunoreactivity was first seen in the interstitial cells of the epididymis at 45 days of age; the testes developed androgen receptor-like immunoreactivity at 60 days of age. The epithelium of prostatic glands contained androgen receptor-like immunoreactivity only in the adult. The presence of androgen receptor-like immunoreactivity during development correlated well with the known androgen dependence of the differentiation of most reproductive organs.
authors.affiliation: Department of Veterinary Anatomy, Iowa State University, Ames 50011, USA. ioana@iastate.edu
authors.forename: I M
authors.initials: IM
authors.lastname: Sonea
authors.forename: J
authors.initials: J
authors.lastname: Iqbal
authors.forename: G S
authors.initials: GS
authors.lastname: Prins
authors.forename: C D
authors.initials: CD
authors.lastname: Jacobson
mesh_terms: D000375:Aging / Q000378:metabolism*; D000818:Animals; D000831:Animals, Newborn; D000906:Antibodies; D002030:Bulbourethral Glands / Q000378:metabolism; D004822:Epididymis / Q000378:metabolism; D004848:Epithelium / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental; D005837:Genitalia, Male / Q000166:cytology / Q000254:growth & development / Q000378:metabolism*; D007150:Immunohistochemistry; D008297:Male; D008648:Mesoderm / Q000378:metabolism; D009893:Opossums; D011467:Prostate / Q000378:metabolism; D011817:Rabbits; D011944:Receptors, Androgen / Q000032:analysis / Q000096:biosynthesis*; D012708:Sertoli Cells / Q000378:metabolism; D013737:Testis / Q000378:metabolism
chemical_list: D000906:Antibodies; D011944:Receptors, Androgen