title: Effects of clomethiazole on radial-arm maze performance following global forebrain ischemia in gerbils.
abstract: The functional and neuroanatomical protective effects of clomethiazole (CMZ) were examined in an animal model of global forebrain ischemia. Gerbils underwent sham-surgery or were rendered ischemic by the application of aneurysm clips to both carotid arteries for 6 min. Three treatment groups received CMZ (50 mg/kg, 100 mg/kg, or 150 mg/kg) 30 min before ischemia, and one group was given 150 mg/kg of CMZ 30 min after ischemia. Following recovery, the gerbils were tested in a radial-arm maze to assess memory functions. Histological evaluation was assessed blindly using a percentile scoring system. The results indicate that pre-ischemic treatment with 100 mg/kg and 150 mg/kg of CMZ reduced brain damage and working memory errors significantly. Treatment dosage of 150 mg/kg of CMZ was the most effective in preventing neuronal damage in the hippocampus and eliminating the working memory deficit typically induced by ischemia.
authors.affiliation: Department of Psychology, University of Saskatchewan, Saskatoon, Canada.
authors.forename: S P
authors.initials: SP
authors.lastname: Liang
authors.forename: R
authors.initials: R
authors.lastname: Kanthan
authors.forename: A
authors.initials: A
authors.lastname: Shuaib
authors.forename: T
authors.initials: T
authors.lastname: Wishart
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001921:Brain / Q000473:pathology; D002545:Brain Ischemia / Q000473:pathology / Q000503:physiopathology* / Q000523:psychology; D002719:Chlormethiazole / Q000494:pharmacology*; D005849:Gerbillinae; D008297:Male; D018782:Maze Learning / Q000187:drug effects*; D008568:Memory / Q000187:drug effects; D009043:Motor Activity / Q000187:drug effects*; D018696:Neuroprotective Agents / Q000494:pharmacology*; D016548:Prosencephalon / Q000098:blood supply*
chemical_list: D018696:Neuroprotective Agents; D002719:Chlormethiazole