title: Assessment of reproductive disorders and birth defects in communities near hazardous chemical sites. I. Birth defects and developmental disorders.
abstract: Members of the workgroup on birth defects and developmental disorders discussed methods to assess structural anomalies, genetic changes and mutations, fetal and infant mortality, functional deficits, and impaired fetal and neonatal growth. Tier 1 assessments for all five adverse reproductive outcomes consist of questionnaires and reviews of medical records rather than laboratory testing of biologic specimens. The work-group members noted a role for neurodevelopmental testing and for limited genetic studies, such as karyotyping in Tier 2 assessments. Emerging methodologies to identify chromosomal aberrations, DNA adducts, and repair inhibition were reserved for Tier 3.
authors.affiliation: University of North Carolina, Chapel Hill, USA.
authors.forename: D A
authors.initials: DA
authors.lastname: Savitz
authors.forename: R L
authors.initials: RL
authors.lastname: Bornschein
authors.forename: R W
authors.initials: RW
authors.lastname: Amler
authors.forename: F I
authors.initials: FI
authors.lastname: Bove
authors.forename: L D
authors.initials: LD
authors.lastname: Edmonds
authors.forename: J W
authors.initials: JW
authors.lastname: Hanson
authors.forename: W E
authors.initials: WE
authors.lastname: Kaye
authors.forename: M
authors.initials: M
authors.lastname: Khoury
authors.forename: M
authors.initials: M
authors.lastname: Kiely
authors.forename: G K
authors.initials: GK
authors.lastname: Lemasters
authors.forename: L E
authors.initials: LE
authors.lastname: Sever
authors.forename: T H
authors.initials: TH
authors.lastname: Shepard
authors.forename: R F
authors.initials: RF
authors.lastname: Spengler
authors.forename: K K
authors.initials: KK
authors.lastname: Steinberg
authors.forename: M
authors.initials: M
authors.lastname: Yeargin-Allsopp
mesh_terms: D000328:Adult; D002675:Child, Preschool; D000013:Congenital Abnormalities / Q000453:epidemiology* / Q000209:etiology; D002658:Developmental Disabilities / Q000453:epidemiology* / Q000209:etiology; D004781:Environmental Exposure / Q000009:adverse effects*; D005260:Female; D005313:Fetal Death / Q000453:epidemiology*; D006256:Hazardous Waste / Q000009:adverse effects*; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D012042:Registries; D014481:United States / Q000453:epidemiology
chemical_list: D006256:Hazardous Waste