A role for secretory phospholipase A2 and C-reactive protein in the removal of injured cells.
The acute phase response is initiated in response to infection or physical trauma and is characterized by an increase in the levels of some plasma proteins. Here, Erik Hack and colleagues suggest that the combined actions of two of these acute phase proteins, secretory phospholipase A2 and C-reactive protein, may serve to promote phagocytosis of injured cells and tissue debris, thereby enhancing inflammation and tissue damage.
Hack
C E
CE
Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, Amsterdam, The Netherlands.
Wolbink
G J
GJ
Schalkwijk
C
C
Speijer
H
H
Hermens
W T
WT
van den Bosch
H
H
D000210:Acute-Phase Reaction / Q000276:immunology; D000818:Animals; D002097:C-Reactive Protein / Q000276:immunology*; D003167:Complement Activation; D006801:Humans; D010587:Phagocytosis / Q000276:immunology; D010741:Phospholipases A / Q000276:immunology*; D054467:Phospholipases A2
D002097:C-Reactive Protein; D010741:Phospholipases A; D054467:Phospholipases A2