title: Cardiovascular risk factors during sequentially combined 17 beta oestradiol and dydrogesterone (Femoston); results from a one-year study in postmenopausal women.
abstract: OBJECTIVE
  To assess the effects of Femoston (2 mg micronised 17 beta oestradiol daily, sequentially combined in one tablet with 10 mg dydrogesterone for 14 days per 28 day cycle) on the serum lipid profile of postmenopausal women.
  
  
  METHODS
  188 healthy postmenopausal women with intact uteri (aged 40 to 65 years) were enrolled in an open, multicentre, one-year study. Serum lipids and lipoproteins were measured at baseline and after 3, 6 and 12 months.
  
  
  RESULTS
  A total of 155 women completed the one-year study. Mean serum levels of total cholesterol and low-density lipoprotein (LDL)-cholesterol were significantly reduced (P < 0.01) at all assessments compared with baseline; the reductions observed at the final assessment were 5 and 20%, respectively. A significant increase of 20% (P < 0.01) was seen in high-density lipoprotein (HDL)-cholesterol levels by month 12. Mean levels of triglycerides were also increased (p < 0.01). Blood pressure and heart rate remained unchanged throughout the study.
  
  
  CONCLUSIONS
  The results show that the overall effects of Femoston on the serum lipid profile are comparable to those found with oestrogen therapy alone and should reduce the risk of cardiovascular disease in postmenopausal women.
authors.affiliation: Jewish General Hospital, Montréal, Quebec, Canada.
authors.forename: M
authors.initials: M
authors.lastname: Gelfand
authors.forename: P
authors.initials: P
authors.lastname: Fugère
authors.forename: F
authors.initials: F
authors.lastname: Bissonnette
mesh_terms: D000328:Adult; D000368:Aged; D001794:Blood Pressure; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D004338:Drug Combinations; D004394:Dydrogesterone / Q000008:administration & dosage / Q000627:therapeutic use*; D004958:Estradiol / Q000008:administration & dosage / Q000627:therapeutic use*; D015914:Estrogen Replacement Therapy; D005260:Female; D005500:Follow-Up Studies; D006331:Heart Diseases / Q000209:etiology*; D006339:Heart Rate; D006801:Humans; D008055:Lipids / Q000097:blood; D008074:Lipoproteins / Q000097:blood; D008875:Middle Aged; D017698:Postmenopause / Q000097:blood; D045167:Progesterone Congeners / Q000008:administration & dosage / Q000627:therapeutic use*; D012307:Risk Factors; D013607:Tablets; D014280:Triglycerides / Q000097:blood
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D004338:Drug Combinations; D008055:Lipids; D008074:Lipoproteins; D045167:Progesterone Congeners; D013607:Tablets; D014280:Triglycerides; D004958:Estradiol; D004394:Dydrogesterone; D002784:Cholesterol