title: [Clinical significant of malassezia furfur specific IgE antibody in atopic dermatitis].
abstract: The clinical significance of AlaSTAT (DPC) Specific IgE for Malassezia furfur (Mf) was evaluated by testing the sera of 147 atopic dermatitis (AD) patients. Patients were from 0 to 52 years old, and the prevalence of positive assay results was analyzed by age, class of reactivity, and degree of face and body symptoms. Evaluations of rhinitis, seborrhea as complications and serum total IgE by RIST were included. The prevalence of Mf specific IgE positive sera was lowest in the 0-2 year age group, and increased swiftly in the 3-9 year age group. The older age is, the higher specific IgE antibody for Mf. The prevalence in the 0-2 year age group was significantly different from the other age groups. Although none of the positive results were above AlaSTAT class 2 in the 0-2 year age group, the positive result above AlaSTAT class 2 increased in the 3-9 year age group and was highest in the older age groups, reaching a peak prevalence at age 20 years. A group of age 20 years or older prevalence was significantly different from the 3-9 and 10-19 years old patients. The prevalence of positive did not correlate with face and body symptoms. Adults were more often Mf positive than children. An increasing prevalence of severe face symptoms in adults did correlate with the increased prevalence of Mf specific IgE in the in sera. The AlaSTAT class 3 and 4 results correlated with more severe face symptoms, and complications by seborrhea. The high AlaSTAT class results also corresponded to high total IgE values.
authors.affiliation: Department of Dermatology, Yokohama Rosai Hospital.
authors.forename: H
authors.initials: H
authors.lastname: Mukai
authors.forename: S
authors.initials: S
authors.lastname: Kaneko
authors.forename: N
authors.initials: N
authors.lastname: Saito
authors.forename: A
authors.initials: A
authors.lastname: Nagase
authors.forename: S
authors.initials: S
authors.lastname: Arai
authors.forename: M
authors.initials: M
authors.lastname: Hiramatsu
authors.forename: H
authors.initials: H
authors.lastname: Kato
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000908:Antibodies, Fungal / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D003876:Dermatitis, Atopic / Q000276:immunology*; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis*; D007223:Infant; D008290:Malassezia / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D015995:Prevalence
chemical_list: D000908:Antibodies, Fungal; D007073:Immunoglobulin E