Vigabatrin-induced gingival overgrowth.
Vigabatrin is a relatively new medication used in the treatment of epilepsia. The present report concerns the use of vigabatrin by a 19-year-old woman. The patient manifested marked gingival overgrowth compatible clinically and histologically with the overgrowth induced by phenytoin, cyclosporine and calcium channel blockers. This is the 1st report of vigabatrin-induced gingival overgrowth. Clinicians should be aware of similar lesions in patients using new anticonvulsants.
Katz
J
J
Department of Oral Medicine, Sheba Medical Center, Tel Hashomer, Israel.
Givol
N
N
Chaushu
G
G
Taicher
S
S
Shemer
J
J
D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects*; D002121:Calcium Channel Blockers / Q000009:adverse effects; D016572:Cyclosporine / Q000009:adverse effects; D017029:Epilepsy, Complex Partial / Q000188:drug therapy; D005260:Female; D005500:Follow-Up Studies; D019214:Gingival Overgrowth / Q000139:chemically induced*; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects; D010672:Phenytoin / Q000009:adverse effects; D020888:Vigabatrin; D005680:gamma-Aminobutyric Acid / Q000009:adverse effects / Q000031:analogs & derivatives*
D000927:Anticonvulsants; D002121:Calcium Channel Blockers; D007166:Immunosuppressive Agents; D005680:gamma-Aminobutyric Acid; D010672:Phenytoin; D016572:Cyclosporine; D020888:Vigabatrin