title: Taches de bougie.
abstract: BACKGROUND
  Posterior segment lesions, including taches de bougie, may be the presenting sign of sarcoidosis. In patients with unrecognized sarcoidosis, taches de bougie may be misinterpreted as the lesions of birdshot chorioretinopathy (BCR) or multifocal choroiditis (MFC).
  
  
  METHODS
  In a retrospective study, the authors identified 22 patients with taches de bougie and sarcoidosis. A tissue biopsy showed noncaseating granulomas in 17 patients. All available ophthalmic and medical records of these patients were reviewed.
  
  
  RESULTS
  Two patterns of taches de bougie were observed. Sixteen patients (73%) had small, discrete white spots in the inferior or nasal periphery, indistinguishable from the lesions of MFC. In six patients (27%), larger, posterior, pale yellow-orange streaks developed that were identical to the lesions of BCR. Visual prognosis was better with posterior streaks. The chest x-ray was normal in 5 of 16 patients with peripheral spots and in 3 of 6 patients with posterior streaks. Serum angiotensin-converting enzyme was negative in 5 of 14 patients. Gallium scan showed increased hilar uptake in five patients, three of whom had a normal chest x-ray. Human lymphocyte antigen A29 was positive in one of nine patients.
  
  
  CONCLUSIONS
  Sarcoidosis should be considered in patients with fundus findings that resemble BCR or MFC. Initial evaluation should include chest x-ray and testing the angiotensin-converting enzyme level. These test results may be negative in patients outside the 20- to 40-year age group for typical sarcoid. Further evaluation with nondirected conjunctival biopsy and whole-body gallium scan may be indicated in certain patients, including (1) those with BCR or MFC with normal chest x-ray and elevated angiotensin-converting enzyme level; (2) patients older than 50 years with MFC; or (3) human lymphocyte antigen A29-negative BCR.
authors.affiliation: Retina Service, Wills Eye Hospital, Philadelphia, Pennsylvania, USA.
authors.forename: T R
authors.initials: TR
authors.lastname: Vrabec
authors.forename: J J
authors.initials: JJ
authors.lastname: Augsburger
authors.forename: D H
authors.initials: DH
authors.lastname: Fischer
authors.forename: J B
authors.initials: JB
authors.lastname: Belmont
authors.forename: D
authors.initials: D
authors.lastname: Tashayyod
authors.forename: H L
authors.initials: HL
authors.lastname: Israel
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001706:Biopsy; D002648:Child; D002675:Child, Preschool; D015862:Choroid Diseases / Q000097:blood / Q000175:diagnosis* / Q000503:physiopathology; D003937:Diagnosis, Differential; D005260:Female; D005451:Fluorescein Angiography; D005500:Follow-Up Studies; D005654:Fundus Oculi; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000097:blood; D010781:Photography; D011379:Prognosis; D012164:Retinal Diseases / Q000097:blood / Q000175:diagnosis* / Q000503:physiopathology; D012189:Retrospective Studies; D012507:Sarcoidosis / Q000097:blood / Q000175:diagnosis* / Q000503:physiopathology; D014792:Visual Acuity
chemical_list: D007703:Peptidyl-Dipeptidase A