title: A case of acute eosinophilic granulocytic leukemia with PML-RAR alpha fusion gene expression and response to all-trans retinoic acid.
abstract: A typical case of eosinophilic granulocytic leukemia with PML-RAR alpha fusion gene expression is reported. The patient achieved complete remission after oral administration of all-trans retinoic acid without any exposure to cytotoxic agents. The facts strongly suggest that the genetic event occurred at the level of pluripotent stem cells.
authors.affiliation: Department of Internal Medicine, Shanghai Chang-Zheng Hospital, China.
authors.forename: R Q
authors.initials: RQ
authors.lastname: Yu
authors.forename: W
authors.initials: W
authors.lastname: Huang
authors.forename: S J
authors.initials: SJ
authors.lastname: Chen
authors.forename: S D
authors.initials: SD
authors.lastname: Jiang
authors.forename: Z
authors.initials: Z
authors.lastname: Chen
mesh_terms: D000368:Aged; D005260:Female; D015870:Gene Expression; D006801:Humans; D015472:Leukemia, Eosinophilic, Acute / Q000188:drug therapy / Q000235:genetics*; D009363:Neoplasm Proteins / Q000032:analysis*; D015514:Oncogene Proteins, Fusion / Q000032:analysis*; D012074:Remission Induction; D014212:Tretinoin / Q000494:pharmacology / Q000627:therapeutic use*; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D009363:Neoplasm Proteins; D015514:Oncogene Proteins, Fusion; C093476:promyelocytic leukemia-retinoic acid receptor alpha fusion oncoprotein; D014212:Tretinoin