[Follow-up on alpha-glutathione-S-transferase serum level following liver transplantation].
The authors followed up six patients after allograft liver transplantation which have been held in the Transplantation and Surgical Clinic. They routinely examined the serum samples of the patients in the post-transplantation period and made a comparison between the serum concentration of alpha-glutathione-S-transferase (alpha-SGT) and conventional liver function enzymes, like aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in association with acute liver allograft rejection. In two cases the authors found that the alpha-glutathione-S-transferase indicated the allograft liver acute rejection-proved by biopsy-2 days earlier than the transminases. In 1 case the alpha-glutathione-S-transferase serum level decrease followed the early post-transplant high level, showed the normalisation of the liver function, but on the 3, day the new elevation was detected, indicating the early acute rejection, the transminases serum levels in all early post-transplant period were elevated. The results of the follow-up-corresponding with the foreign researches-proved that the alpha-glutathione-S-transferase is a reliable marker of the allograft liver acute rejection, in some cases indicates the rejection diagnosis earlier than the conventional liver function enzymes like transaminases.
Varga
M
M
Semmelweis Orvostudományi Egyetem, Transzplantációs és Sebészeti Klinika, Budapest.
Sárváry
E
E
Sulyok
B
B
Perner
F
F
D000410:Alanine Transaminase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D005500:Follow-Up Studies; D005982:Glutathione Transferase / Q000097:blood*; D006084:Graft Rejection / Q000201:enzymology; D006801:Humans; D016031:Liver Transplantation; D011184:Postoperative Period; D014184:Transplantation, Homologous
D005982:Glutathione Transferase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase
Alfa-glutation-S-transzferáz szérumszint követése májtranszplantáció után.