Can misoprostol and omeprazole reduce nicotine and ethanol induced gastric mucosal injury? A quantitative macroscopic and microscopic analysis in rats.
We compared the effects of misoprostol, omeprazole and methylcellulose (control) on gastric mucosal injury induced by nicotine and/or ethanol. The results demonstrate that misoprostol and omeprazole each significantly reduce macroscopic injury and deep injury at a microscopic level (P < 0.05) induced by nicotine alone, ethanol alone or a combination of ethanol and nicotine. Misoprostol and omeprazole each reduced the leakage of fluorescein isothiocyanate-albumin into the interstitium in the gastric mucosa. Misoprostol and omeprazole are each effective in preventing injury induced by nicotine and ethanol and vascular factors are involved.
Hui
W M
WM
Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong.
Ho
J
J
Chen
B W
BW
Cho
C H
CH
Branicki
F J
FJ
Lam
S K
SK
D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D000431:Ethanol / Q000009:adverse effects*; D016650:Fluorescein-5-isothiocyanate; D005456:Fluorescent Dyes; D005753:Gastric Mucosa / Q000187:drug effects*; D008297:Male; D016595:Misoprostol / Q000494:pharmacology*; D009538:Nicotine / Q000009:adverse effects*; D009853:Omeprazole / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley
D000897:Anti-Ulcer Agents; D005456:Fluorescent Dyes; D016595:Misoprostol; D000431:Ethanol; D009538:Nicotine; D016650:Fluorescein-5-isothiocyanate; D009853:Omeprazole