title: Sensitivity of Aeromonas hydrophila carbapenemase to delta3-cephems: comparative study with other metallo-beta-lactamases.
abstract: Ceftriaxone and ceftriaxone S-oxide behaved as inactivators against the metallo-beta-lactamase of Aeromonas hydrophila AE036 and as substrates for the zinc beta-lactamase produced by Bacillus cereus (569/H/9) and Stenotrophomonas maltophilia ULA 511. Moreover, RO 09-1428, a catechol-cephalosporin, was not recognized by the A. hydrophila enzyme. Panipenem, cephalosporin C, cephalosporin C-gamma-lactone, and loracarbef were substrates for the three studied beta-lactamases.
authors.affiliation: Dipartimento di Scienze e Tecnologie Biomediche Cattedra di Chimica Biologica e di Enzimologia, Università degli Studi dell'Aquila, Coppito (L'Aquila), Italy.
authors.forename: A
authors.initials: A
authors.lastname: Felici
authors.forename: M
authors.initials: M
authors.lastname: Perilli
authors.forename: N
authors.initials: N
authors.lastname: Franceschini
authors.forename: G M
authors.initials: GM
authors.lastname: Rossolini
authors.forename: M
authors.initials: M
authors.lastname: Galleni
authors.forename: J M
authors.initials: JM
authors.lastname: Frere
authors.forename: A
authors.initials: A
authors.lastname: Oratore
authors.forename: G
authors.initials: G
authors.lastname: Amicosante
mesh_terms: D016980:Aeromonas hydrophila / Q000187:drug effects / Q000201:enzymology*; D001426:Bacterial Proteins; D003524:Cyclosporins / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D006868:Hydrolysis; D007700:Kinetics; D065093:beta-Lactamase Inhibitors; D001618:beta-Lactamases
chemical_list: D001426:Bacterial Proteins; D003524:Cyclosporins; D004791:Enzyme Inhibitors; D065093:beta-Lactamase Inhibitors; D001618:beta-Lactamases; C063912:carbapenemase