title: Primary localized nodular tongue amyloidosis associated with Sjögren's syndrome.
abstract: We describe a case of primary localized nodular tongue amyloidosis associated with Sjögren's syndrome in a 62-year-old woman. The presence of Sjögren's syndrome was confirmed both serologically and histologically. The amyloid tumor, which was marginally excised, recurred 3 years later and was re-excised. Immunohistochemical examination revealed that the amyloid protein was of the AL (lambda-light chain) type. Infiltration of plasma cells was observed around the minor salivary glands of the tongue surrounded by amyloid. The relationship between the plasma cells and amyloid deposition is discussed.
authors.affiliation: Department of Otorhinolaryngology, Tokyo Medical and Dental University, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Haraguchi
authors.forename: K
authors.initials: K
authors.lastname: Ohashi
authors.forename: M
authors.initials: M
authors.lastname: Yamada
authors.forename: M
authors.initials: M
authors.lastname: Hasegawa
authors.forename: S
authors.initials: S
authors.lastname: Maeda
authors.forename: A
authors.initials: A
authors.lastname: Komatsuzaki
mesh_terms: D000682:Amyloid / Q000032:analysis; D000686:Amyloidosis / Q000150:complications* / Q000473:pathology; D003593:Cytoplasm / Q000648:ultrastructure; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D010950:Plasma Cells / Q000473:pathology / Q000648:ultrastructure; D012008:Recurrence; D012470:Salivary Glands, Minor / Q000473:pathology / Q000648:ultrastructure; D012859:Sjogren's Syndrome / Q000150:complications* / Q000473:pathology; D014059:Tongue / Q000473:pathology / Q000648:ultrastructure; D014060:Tongue Diseases / Q000150:complications* / Q000473:pathology
chemical_list: D000682:Amyloid; C035222:amyloid protein AL