title: Anatomical and physiological simulation for respiratory mechanics.
abstract: Injuries in trauma affect anatomical structures, indirectly affecting physiological systems through mechanical behavior and physical proximity. This paper describes the theory for and preliminary results from our approach to couple a three-dimensional (3-D) anatomical model of the chest with a physiological model of respiratory mechanics. In particular, we investigated behavior in quiet, normal breathing and in an open, sucking chest wound. We envision that our integrated simulation of respiratory anatomy and respiratory mechanics could assist students in visualizing and predicting relationships between structural-anatomical and functional-physiological changes in an interactive, 3-D environment.
authors.affiliation: Center for Human Modeling and Simulation, University of Pennsylvania, Philadelphia 19104-6389, USA. kaye@linc.cis.upenn.edu
authors.forename: J
authors.initials: J
authors.lastname: Kaye
authors.forename: F P
authors.initials: FP
authors.lastname: Primiano
authors.forename: D
authors.initials: D
authors.lastname: Metaxas
mesh_terms: D003198:Computer Simulation; D003194:Computer-Assisted Instruction; D004501:Education, Medical; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008168:Lung / Q000503:physiopathology; D011030:Pneumothorax / Q000209:etiology / Q000503:physiopathology*; D015656:Respiratory Mechanics; D013898:Thoracic Injuries / Q000150:complications / Q000503:physiopathology*; D013909:Thorax / Q000503:physiopathology; D014950:Wounds, Penetrating / Q000503:physiopathology