Two new isomers of domoic acid from a red alga, Chondria armata.
Isodomoic acids G and H, two new isomers of the neurotoxin domoic acid, along with isodomoic acids A, B, E and F, were isolated from a red alga, Chondria armata, collected at the southern tip of Kyushu Island. The structures of two of these were deduced to be (E, E) and (Z, E) isomers of 2-carboxy-4-(5-carboxy-l-methyl-2-hexenylidene)-3-pyrro- lidineacetic acid, based on electrospray ionization mass and [1H]nuclear magnetic resonance spectral analyses including [1H-1H]correlation spectroscopy and nuclear Overhauser effect correlation spectroscopy.
Zaman
L
L
Laboratory of Marine Botany and Environmental Science, Faculty of Fisheries, Kagoshima University, Japan.
Arakawa
O
O
Shimosu
A
A
Onoue
Y
Y
Nishio
S
S
Shida
Y
Y
Noguchi
T
T
D002851:Chromatography, High Pressure Liquid; D007536:Isomerism; D007608:Kainic Acid / Q000031:analogs & derivatives* / Q000032:analysis / Q000737:chemistry / Q000302:isolation & purification; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D015394:Molecular Structure; D009467:Neuromuscular Depolarizing Agents / Q000032:analysis / Q000737:chemistry / Q000302:isolation & purification*; D000461:Rhodophyta
D009467:Neuromuscular Depolarizing Agents; C012301:domoic acid; D007608:Kainic Acid