Spiking fevers with clozapine treatment.
Clozapine often causes low-grade fever and less frequently spiking fever. We describe three cases of spiking fever that occurred in the first 3 weeks of clozapine therapy. A new set of side effects of clozapine is identified, which includes spiking fever, respiratory and gastrointestinal symptoms, and neutrophilia. Possible mechanisms are discussed.
Trémeau
F
F
Department of Clinical Psychobiology, New York State Psychiatric Institute, New York 10032, USA.
Clark
S C
SC
Printz
D
D
Kegeles
L S
LS
Malaspina
D
D
D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects*; D003024:Clozapine / Q000009:adverse effects*; D005260:Female; D005334:Fever / Q000139:chemically induced*; D005767:Gastrointestinal Diseases / Q000139:chemically induced; D006801:Humans; D007958:Leukocyte Count; D008171:Lung Diseases / Q000139:chemically induced; D008297:Male; D009504:Neutrophils; D011618:Psychotic Disorders / Q000188:drug therapy; D012563:Schizophrenia, Paranoid / Q000188:drug therapy
D014150:Antipsychotic Agents; D003024:Clozapine