High frequencies of CYP2C19 mutations and poor metabolism of proguanil in Vanuatu.
Kaneko
A
A
Kaneko
O
O
Taleo
G
G
Björkman
A
A
Kobayakawa
T
T
D000483:Alleles; D000962:Antimalarials / Q000378:metabolism*; D001189:Aryl Hydrocarbon Hydroxylases; D018890:Chemoprevention; D065731:Cytochrome P-450 CYP2C19; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics*; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D016778:Malaria, Falciparum / Q000517:prevention & control; D006899:Mixed Function Oxygenases / Q000235:genetics*; D009154:Mutation; D016133:Polymerase Chain Reaction; D002727:Proguanil / Q000378:metabolism*; D009514:Vanuatu
D000962:Antimalarials; D003577:Cytochrome P-450 Enzyme System; D006899:Mixed Function Oxygenases; D001189:Aryl Hydrocarbon Hydroxylases; C045793:CYP2C19 protein, human; D065731:Cytochrome P-450 CYP2C19; D002727:Proguanil