title: Acute renal failure after binge drinking of alcohol and nonsteroidal antiinflammatory drug ingestion.
abstract: A case of reversible acute renal failure (ARF) following binge drinking together with the transient use of a nonsteroidal antiinflammatory drug (NSAID) is described. After binge drinking. the patient experienced hyperdipsia, and the volume of his urine decreased. Subsequently, he took an NSAID to relieve systemic joint pain associated with low grade fever, and then he had complete anuria. One day after taking the NSAID, he visited our hospital, and was found to have severe renal dysfunction accompanied by severe liver damage (blood urea nitrogen and creatinine concentrations were 57 and 5.4 mg/dl, respectively). The impaired renal function progressed over the first three hospital days, as reflected by an elevated creatinine concentration to 11.6 mg/dl. Nine treatment sessions of hemodialysis were, therefore, required to recover the loss of renal function. The present case suggests that binge drinking may be a potential risk factor for ARF in the presence of NSAIDs.
authors.affiliation: Department of Internal Medicine, Saiseikai Central Hospital, Tokyo.
authors.forename: N
authors.initials: N
authors.lastname: Tsuboi
authors.forename: H
authors.initials: H
authors.lastname: Yoshida
authors.forename: K
authors.initials: K
authors.lastname: Shibamura
authors.forename: M
authors.initials: M
authors.lastname: Hikita
authors.forename: H
authors.initials: H
authors.lastname: Tomonari
authors.forename: S
authors.initials: S
authors.lastname: Kuriyama
authors.forename: O
authors.initials: O
authors.lastname: Sakai
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology*; D000428:Alcohol Drinking / Q000009:adverse effects*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D003681:Dehydration / Q000209:etiology; D000431:Ethanol / Q000506:poisoning*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012206:Rhabdomyolysis / Q000209:etiology
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000431:Ethanol