title: Impact of severity of coronary artery stenosis and the collateral circulation on the functional outcome of dyssynergic myocardium after revascularization in patients with healed myocardial infarction and chronic left ventricular dysfunction.
abstract: The aim of this study was to assess the influence of the severity of coronary artery stenosis and the grade of collateral circulation on myocardial viability in patients with chronic left ventricular (LV) dysfunction undergoing coronary artery bypass grafting. Forty patients (age 59 +/- 8 years) with old myocardial infarction were studied by dobutamine stress echocardiography (DSE) before coronary artery bypass grafting. LV function was assessed using a 16-segment, 5-grade score model. Viability and functional recovery were respectively defined as a reduction in wall motion score > or = 1 at low-dose DSE and at follow-up echocardiograms obtained 3 months after surgery. There were 56 stenotic coronary arteries subtending severely dyssynergic myocardial segments, of which 38 were occluded. Among 186 severely dyssynergic segments, functional recovery occurred in 42 (23%). There was no significant difference between myocordial regions with patent or occluded coronary arteries with respect to prevalence of viability or functional recovery and percentage of viable or recovered segments relative to the total number of dyssynergic segments. In patients with total occlusion, these parameters were not different between regions with different collateral grades. Sensitivity, specificity, and accuracy of low-dose DSE for prediction of regional functional recovery were 71%, 90%, and 86%, respectively. It is concluded that in patients with chronic LV dysfunction, the presence of total occlusion of coronary arteries supplying severely dyssynergic regions does not imply a lower prevalence or extent of functional recovery after revascularization, regardless of the grade of angiographically visualized collaterals. Low-dose DSE can identify myocardial regions with a high probability of functional improvement after revascularization regardless of the severity of underlying coronary stenosis or collateralization of the involved coronary vessel.
authors.affiliation: Thoraxcenter, University Hospital Rotterdam-Dijkzigt, Erasmus University, The Netherlands.
authors.forename: A
authors.initials: A
authors.lastname: Elhendy
authors.forename: J H
authors.initials: JH
authors.lastname: Cornel
authors.forename: J R
authors.initials: JR
authors.lastname: Roelandt
authors.forename: P R
authors.initials: PR
authors.lastname: Nierop
authors.forename: R T
authors.initials: RT
authors.lastname: van Domburg
authors.forename: M L
authors.initials: ML
authors.lastname: Geleijnse
authors.forename: G
authors.initials: G
authors.lastname: Trocino
authors.forename: J J
authors.initials: JJ
authors.lastname: Bax
authors.forename: M M
authors.initials: MM
authors.lastname: Ibrahim
authors.forename: P M
authors.initials: PM
authors.lastname: Fioretti
mesh_terms: D003097:Collateral Circulation / Q000502:physiology; D017023:Coronary Angiography; D001026:Coronary Artery Bypass; D003326:Coronary Circulation / Q000502:physiology; D003327:Coronary Disease / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000503:physiopathology; D004280:Dobutamine; D004452:Echocardiography; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis / Q000503:physiopathology / Q000601:surgery*; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity; D016896:Treatment Outcome; D014654:Vascular Patency / Q000502:physiology; D018487:Ventricular Dysfunction, Left / Q000175:diagnosis / Q000503:physiopathology / Q000601:surgery*
chemical_list: D004280:Dobutamine