Effect of UV-irradiation, gamma irradiation and praziquantel on infected Biomphalaria alexandrina snails.
Schistosomiasis control represent the main target of many research programme allover the world. Effect of physical (UV- and gamma-irradiation) treatment as well as chemical (PZQ) treatment on infected laboratory bred Biomphalria alexandrina snails have been studied. Gamma irradiation and PZQ-treatment induced high rate of mortality than UV-irradiated and non-treated control snails. The cercarial production was severely reduced as a result of UV-, gamma-irradiation and PZQ-treatment. Pre-patent period was significantly increased in gamma-irradiated and PZQ-treated groups than UV-irradiated and control groups. Gamma irradiation and PZQ-treatment showed severe effects on hermaphrodite gland and cercariae. Trials of experimental infection in swiss albino mice revealed that low rate of infection (9.7% and 1.3%) was induced by cercarial shedding from UV-irradiated and PZQ-treated snails respectively. Whereas, cercarial production of gamma-irradiated snails failed to induce infection in swiss mice.
Mostafa
B B
BB
Theodor Bilharz Research Institute, Imbaba, Giza, Egypt.
Gad
H S
HS
D000818:Animals; D000980:Antiplatyhelmintic Agents / Q000494:pharmacology*; D001700:Biomphalaria / Q000187:drug effects / Q000469:parasitology* / Q000528:radiation effects; D004199:Disease Vectors; D005260:Female; D005720:Gamma Rays; D051379:Mice; D011223:Praziquantel / Q000494:pharmacology*; D012547:Schistosoma / Q000187:drug effects / Q000502:physiology / Q000528:radiation effects; D012552:Schistosomiasis / Q000517:prevention & control*; D014466:Ultraviolet Rays
D000980:Antiplatyhelmintic Agents; D011223:Praziquantel