title: Spiking fevers with clozapine treatment.
abstract: Clozapine often causes low-grade fever and less frequently spiking fever. We describe three cases of spiking fever that occurred in the first 3 weeks of clozapine therapy. A new set of side effects of clozapine is identified, which includes spiking fever, respiratory and gastrointestinal symptoms, and neutrophilia. Possible mechanisms are discussed.
authors.affiliation: Department of Clinical Psychobiology, New York State Psychiatric Institute, New York 10032, USA.
authors.forename: F
authors.initials: F
authors.lastname: Trémeau
authors.forename: S C
authors.initials: SC
authors.lastname: Clark
authors.forename: D
authors.initials: D
authors.lastname: Printz
authors.forename: L S
authors.initials: LS
authors.lastname: Kegeles
authors.forename: D
authors.initials: D
authors.lastname: Malaspina
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects*; D003024:Clozapine / Q000009:adverse effects*; D005260:Female; D005334:Fever / Q000139:chemically induced*; D005767:Gastrointestinal Diseases / Q000139:chemically induced; D006801:Humans; D007958:Leukocyte Count; D008171:Lung Diseases / Q000139:chemically induced; D008297:Male; D009504:Neutrophils; D011618:Psychotic Disorders / Q000188:drug therapy; D012563:Schizophrenia, Paranoid / Q000188:drug therapy
chemical_list: D014150:Antipsychotic Agents; D003024:Clozapine