Comparison of uptake of 99mTc-alkylisonitriles in the rat 9L gliosarcoma tumor model.
The accumulation of three 99mTc(I) alkyl isonitriles was compared in vitro and in vivo using 9L gliosarcoma cells. In vitro, the uptake of 99mTc-EIBI and 99mTc-EPI was higher than that of 99mTc-MIBI. In vivo, however, there was no difference in the tumor concentration at 15 or 60 min postinjection and only a small difference at 24 h. The differences in uptake observed in vitro are apparently offset in vivo by differences in delivery of the tracers to the tumor.
Packard
A B
AB
Division of Nuclear Medicine, Children's Hospital, Boston, MA 02115, USA.
Barbarics
E
E
Kronauge
J F
JF
Wen
P Y
PY
Day
P J
PJ
Jones
A G
AG
D000818:Animals; D001932:Brain Neoplasms / Q000000981:diagnostic imaging / Q000378:metabolism*; D018316:Gliosarcoma / Q000000981:diagnostic imaging / Q000378:metabolism*; D008297:Male; D009570:Nitriles / Q000493:pharmacokinetics*; D015609:Organotechnetium Compounds / Q000493:pharmacokinetics*; D011877:Radionuclide Imaging; D051381:Rats; D017256:Technetium Tc 99m Sestamibi / Q000493:pharmacokinetics*; D014018:Tissue Distribution; D014407:Tumor Cells, Cultured
D009570:Nitriles; D015609:Organotechnetium Compounds; C105923:technetium Tc 99m ethoxypropylisonitrile; C105922:technetium Tc 99m ethoxyisobutylisonitrile; D017256:Technetium Tc 99m Sestamibi