A comparison of myogenic and endothelial properties of myometrial and omental resistance vessels in late pregnancy.
OBJECTIVE
Our purpose was to compare myometrial and omental resistance arteries from term pregnant women with respect to myogenic behavior in the presence or absence of a nitric oxide synthase inhibitor and to compare distensibility and acetylcholine-mediated dilatation in these vessels.


METHODS
Intramyometrial (n = 17) and omental (n = 14) resistance arteries from term normal pregnant women were studied in a pressurized arteriograph system. Myogenic tone was evaluated during increments in intraluminal pressure from 20 to 120 mm Hg with and without inhibition of nitric oxide synthase. Endothelium-dependent relaxation was assessed by evaluating the response to acetylcholine (10(-6) mol/L) in arteries pressurized at 70 mm Hg.


RESULTS
Myogenic tone was greater at all pressure steps in the myometrial than in the omental arteries (p < 0.05). Inhibition of nitric oxide synthase with N(omega)-nitro-L-arginine had no influence on myogenic tone in either group. Relaxation to acetylcholine was greater in myometrial (18% +/- 4%) compared with omental vessels (7% +/- 2%, p < 0.05). The passive distensibility (Ca++-free solution and in the presence of papaverine) of arteries from the myometrium and the omentum was similar.


CONCLUSIONS
Normal pregnancy is associated with different mechanical properties of resistance vessels from the two vascular beds studied. Basal nitric oxide release does not modify myogenic tone, at least under no-flow conditions. Acetylcholine-induced relaxation is greater in myometrial than in omental arteries.
Kublickiene
K R
KR
Department of Obstetrics and Gynecology, Karolinska Institute, Huddinge University Hospital, Sweden.
Kublickas
M
M
Lindblom
B
B
Lunell
N O
NO
Nisell
H
H
D000109:Acetylcholine / Q000494:pharmacology; D005260:Female; D006801:Humans; D007743:Labor, Obstetric; D009215:Myometrium / Q000098:blood supply*; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors; D009852:Omentum / Q000098:blood supply*; D011247:Pregnancy; D011263:Pregnancy Trimester, Third; D011312:Pressure; D014655:Vascular Resistance / Q000187:drug effects
D019001:Nitric Oxide Synthase; D000109:Acetylcholine