Medicinal foodstuffs. V. Moroheiya. (1): Absolute stereostructures of corchoionosides A, B, and C, histamine release inhibitors from the leaves of Vietnamese Corchorus olitorius L. (Tiliaceae).
Three new ionone glucosides named corchoionosides A, B, and C were isolated from the leaves of Corchorus olitorius, commonly called "moroheiya" in Japanese, together with seven known compounds, an ionone glucoside (6S,9R)-roseoside, a monoterpene glucoside betulalbuside A, two flavonol glucosides astragalin and isoquercitrin, two coumarin glucosides scopolin and cichoriine, and chlorogenic acid. The absolute stereostructures of corchoionosides A, B, and C were determined by chemical and physiochemical evidence, which included the result of application of a modified Mosher's method, the CD helicity rule, and chemical correlation with (6S,9R)-roseoside. Corchoionosides A and B and (6S,9R)-roseoside were found to inhibit the histamine release from rat peritoneal exudate cells induced by antigen-antibody reaction.
Yoshikawa
M
M
Kyoto Pharmaceutical University, Japan.
Shimada
H
H
Saka
M
M
Yoshizumi
S
S
Yamahara
J
J
Matsuda
H
H
D000818:Animals; D000937:Antigen-Antibody Reactions; D005960:Glucosides / Q000737:chemistry* / Q000494:pharmacology; D006636:Histamine Release / Q000187:drug effects; D008958:Models, Molecular; D010936:Plant Extracts / Q000737:chemistry*; D051381:Rats; D013237:Stereoisomerism
D005960:Glucosides; D010936:Plant Extracts; C105663:corchoionoside A; C105664:corchoionoside B; C105665:corchoionoside C