The chromosomal organization of the human endogenous retrovirus-like sequence HERV-H: clustering of the HERV-H sequences in a 300-kb region close to the GRPR locus on the X chromosome.
Within the haploid genome there are approximately 1,000 copies of the human endogenous retrovirus-like sequence, HERV-H. Although these sequences are scattered throughout the entire genome, in situ hybridization experiments revealed that there are discrete clusters positioned on chromosomes 1 p and 7 q. In this study, we have located three HERV-H sequences which were unexpectedly clustered within a 300-kilobase region close to the GRPR locus on the X chromosome. In previous studies, no clustering of this sequence has been reported at this locus. Our finding demonstrates that, like other repetitive sequences, clustering of HERV-H occurs in the human genome, although these sequences may not always be detected by in situ hybridization methods.
Shiraishi
M
M
Oncogene Division, National Cancer Center Research Institute, Tokyo, Japan. mshirais@ncc.go.jp
Alitalo
T
T
Sekiya
T
T
D001483:Base Sequence; D015139:Blotting, Southern; D002874:Chromosome Mapping; D018244:Chromosomes, Artificial, Yeast; D003360:Cosmids; D004279:DNA, Viral / Q000235:genetics*; D015698:Genomic Library; D006801:Humans; D008969:Molecular Sequence Data; D005810:Multigene Family; D012091:Repetitive Sequences, Nucleic Acid / Q000235:genetics*; D012190:Retroviridae / Q000235:genetics*; D016415:Sequence Alignment; D017422:Sequence Analysis, DNA; D012689:Sequence Homology, Nucleic Acid; D014960:X Chromosome / Q000235:genetics*
D004279:DNA, Viral