title: Long-term potentiation and depression in layer III and V pyramidal neurons of the cat sensorimotor cortex in vitro.
abstract: Synaptic plasticity of the cat sensorimotor cortex was examined intracellularly in vitro. After tetanic stimulation of the white matter, layer III and V pyramidal neurons showed long-term potentiation (LTP) of EPSPs in high incidence without GABA(A) antagonist. The incidence and magnitude of LTP were very conspicuous in layer V cells. After an NMDA receptor antagonist application, the synaptic potentiation was blocked completely in layer III but not in layer V cells. Long-term depression (LTD) of the evoked EPSPs was also induced by the same stimulation in some layer III cells, where a transient hyperpolarization of the membrane potential was observed during tetanus.
authors.affiliation: Department of Physiology, Faculty of Medicine, Mie University, Tsu Mie, Japan. kitagawa@doc.medic.mie-u.ac.jp
authors.forename: H
authors.initials: H
authors.lastname: Kitagawa
authors.forename: Y
authors.initials: Y
authors.lastname: Nishimura
authors.forename: K
authors.initials: K
authors.lastname: Yoshioka
authors.forename: M
authors.initials: M
authors.lastname: Lin
authors.forename: T
authors.initials: T
authors.lastname: Yamamoto
mesh_terms: D015763:2-Amino-5-phosphonovalerate / Q000494:pharmacology; D000818:Animals; D002415:Cats; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology; D066298:In Vitro Techniques; D017774:Long-Term Potentiation; D009044:Motor Cortex / Q000166:cytology / Q000502:physiology*; D009473:Neuronal Plasticity; D017966:Pyramidal Cells / Q000502:physiology*; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors / Q000502:physiology; D013003:Somatosensory Cortex / Q000166:cytology / Q000502:physiology*; D009435:Synaptic Transmission / Q000187:drug effects
chemical_list: D018691:Excitatory Amino Acid Antagonists; D016194:Receptors, N-Methyl-D-Aspartate; D015763:2-Amino-5-phosphonovalerate