title: Regeneration of tactile lamellar corpuscles of the rat after postnatal freeze injury.
abstract: Tactile lamellar corpuscles were studied after freeze injury of rat toe pads under normal conditions and following permanent denervation in 1- to 65-day-old animals. In the innervated skin, digital corpuscles redifferentiated in all age groups examined during development and maturation. Characteristic of the reinnervated skin was a great diversity in the shape and size of newly formed corpuscles. Small corpuscles with only 1-3 lamellae around their terminals and well-developed corpuscles of about normal size with up to 15 lamellae were sometimes found within the same sample of skin. The regenerated corpuscles were reduced in number; they reappeared in only 50% of dermal papillae in the toe pads after freeze injury in 7-week-old rats, compared with approximately 100% of dermal papillae that contained lamellar corpuscles in normal toe-pad skin. In denervated toes, occasional corpuscular lamellar structures appeared first after freeze injury applied to 34-day-old rats. In the toe pads denervated and injured by freezing in 42- and 49-day-old rats, lamellar structures redifferentiated in about 10% of the papillae, and in 23.5% after freeze injury applied to 2-month-old rats. Unsatisfactory preservation of basal laminae at the former sites of the corpuscles and in the acellular peripheral nerve stumps, and/or insufficient migration of Schwann cells, may be responsible for the absence or abortive regeneration of lamellar structures in denervated skin of food pads after freeze injury in young rats.
authors.affiliation: Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic. ijirm@biomed.cas.cz
authors.forename: I
authors.initials: I
authors.lastname: Jirmanová
authors.forename: P
authors.initials: P
authors.lastname: Dubový
authors.forename: J
authors.initials: J
authors.lastname: Zelená
mesh_terms: D000818:Animals; D005260:Female; D005528:Foot / Q000294:innervation / Q000473:pathology / Q000503:physiopathology*; D018409:Foot Injuries / Q000209:etiology / Q000473:pathology / Q000503:physiopathology*; D005615:Freezing; D006614:Hindlimb / Q000294:innervation / Q000503:physiopathology / Q000648:ultrastructure; D008297:Male; D008465:Mechanoreceptors / Q000254:growth & development / Q000502:physiology* / Q000648:ultrastructure; D051381:Rats; D017208:Rats, Wistar; D012038:Regeneration; D012867:Skin / Q000294:innervation / Q000473:pathology