[The serum level of soluble interleukin-2 receptors in patients with rheumatoid arthritis].
Rheumatoid arthritis is a systemic chronic inflammatory disease characterized by development of severe destruction of the joints caused by uncontrollable activation of cellular immunity. Activated T-lymphocytes synthesize interleukin-2 (IL-2) and specific membrane soluble receptors (sIL-2r) for this cytokine. The level of sIL-2r release is proportional to the number of molecules expressed on the membrane of activated immunocompetent cells. The data are provided for 59 patients with a significant RA diagnosis according to criteria of the American Rheumatology Board. Serum sIL-2r level was measured by enzyme immunoassay. It was found higher in RA patients than in controls (p < 0.001). Concentrations of sIL-2r increased with activation of RA. It is suggested that determination of sIL-2r extends potentialities of laboratory diagnosis of RA activity which is important for evaluating effectivity of the treatment and RA prognosis.
Medvedev
A N
AN
Korshunov
N I
NI
Nasonov
E L
EL
Baranov
A A
AA
Shilkina
N P
NP
D000293:Adolescent; D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000097:blood* / Q000175:diagnosis; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D015375:Receptors, Interleukin-2 / Q000097:blood*; D012995:Solubility
D015375:Receptors, Interleukin-2
Syvorotochnyĭ uroven' rastvorimykh interleĭkinov-2-retseptorov u bol'nykh revmatoidnym artritom.