[Detection of GBV-C RNA among non B non C hepatocellular carcinoma patients].
Recently, an RNA virus member of the flaviviridae, GBVirus C(GBV-C) was isolated from the serum of patient with cryptogenic hepatitis, but clinical significance for this virus has been not known now. To estimate the prevalence of GBV-C, we investigated the presence of GBV-C RNA by reverse transcription-nested polymerase chain reaction in the serum from various liver disease patients. The results were summarized as follows: [Table: see text] Among these, only 5 patients gave positive results, and these 5 cases had the history of blood transfusion before. Especially both non B non C HCC patient and non A non B non C fulminant hepatitis patient were negative for GBV-C on admission, while positive after blood transfusion as treatment. In the non B non C HCC patient, GBV-C RNA persisted over a period of several months after transfusion, while no remarkable elevation of ALT was observed. These results demonstrated that GBV-C/HGV may be transfusion-transmissible, and may not associated with severe chronic liver disease such as liver cirrhosis or HCC.
Kitamoto
M
M
First Department of Internal Medicine, Hiroshima University School of Medicine.
Moriya
T
T
Sasaki
F
F
Katayama
K
K
Yoshizawa
H
H
Asahara
T
T
Nakanishi
T
T
D015415:Biomarkers / Q000097:blood; D006528:Carcinoma, Hepatocellular / Q000821:virology*; D018067:Flaviviridae / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D008113:Liver Neoplasms / Q000821:virology*; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D012367:RNA, Viral / Q000097:blood*; D065227:Transfusion Reaction
D015415:Biomarkers; D012367:RNA, Viral