title: Inhibition and attention deficit hyperactivity disorder.
abstract: This paper updates the author's earlier hypothesis that Attention Deficit Hyperactivity Disorder (ADHD) reflects underactivity in Gray's Behavioral Inhibition System. Five areas of research are reviewed: (1) studies using the stop-signal task, (2) studies of errors of commission, (3) a study of inhibition indexed by eye movements, (4) a neuroimaging study of the corpus callosum, and (5) a study on the prediction of response to methylphenidate. Data from the many different dependent variables in these studies are interpreted as supporting disinhibition as a core deficit in ADHD.
authors.affiliation: University of Miami, Coral Gables, Florida 33124, USA.
authors.forename: H C
authors.initials: HC
authors.lastname: Quay
mesh_terms: D001289:Attention Deficit Disorder with Hyperactivity / Q000175:diagnosis* / Q000188:drug therapy / Q000523:psychology; D001931:Brain Mapping; D000697:Central Nervous System Stimulants / Q000009:adverse effects / Q000627:therapeutic use; D002648:Child; D006801:Humans; D007266:Inhibition, Psychological; D008774:Methylphenidate / Q000627:therapeutic use
chemical_list: D000697:Central Nervous System Stimulants; D008774:Methylphenidate