Endogenous and copper-induced lipid peroxidation and antioxidant activity of serum in hypercholesterolemic subjects.
Endogenous malondialdehyde and diene conjugate levels were increased in hypercholesterolemic subjects with serum cholesterol levels above 240 mg/dl as compared to normocholesterolemic subjects (below 20 mg/dl). A decrease in vitamin E/cholesterol and vitamin C/cholesterol ratios was observed in serum of hypercholesterolemic individuals. However, the susceptibility of serum to copper-induced lipid peroxidation and antioxidant activity were found unchanged. The present study indicates that hypercholesterolemic subjects have a high level of circulating lipid peroxides and that a higher tendency towards atherosclerosis in these subjects may be related to increased baseline levels of serum lipid peroxides.
Mehmetçik
G
G
Department of Biochemistry, Istanbul Faculty of Medicine, University of Istanbul, Capa, Turkey.
Toker
G
G
Uysal
M
M
D000328:Adult; D000975:Antioxidants / Q000378:metabolism*; D001205:Ascorbic Acid / Q000097:blood / Q000494:pharmacology; D002784:Cholesterol / Q000097:blood; D003300:Copper / Q000494:pharmacology*; D005231:Fatty Acids, Unsaturated / Q000097:blood; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood*; D015227:Lipid Peroxidation / Q000187:drug effects* / Q000502:physiology; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D014810:Vitamin E / Q000097:blood / Q000494:pharmacology
D000975:Antioxidants; D005231:Fatty Acids, Unsaturated; D014810:Vitamin E; D008315:Malondialdehyde; D003300:Copper; D002784:Cholesterol; D001205:Ascorbic Acid