Erythrocyte hemolysis by organic tin and lead compounds.
The effect of trialkyllead and trialkyltin on pig erythrocyte hemolysis has been studied and compared. The results of experiments showed that the hemolytic activity of organoleads increases with their hydrophobicity and follows the sequence: triethyllead chloride < tri-n-propyllead chloride < tributyllead chloride. And similarly in the case of organotins: triethyltin chloride < tri-n-propyltin chloride < tributyltin chloride. Comparison of the hemolytic activity of organoleads and organotins indicates that the lead compounds exhibit higher hemolytic activity. The methods of quantum chemistry allowed to determine the maximum electric potential of the ions R3Pb+ and R3Sn+, and suggest a relationship between the potential and toxicity.
Kleszcyńska
H
H
Department of Physics and Biophysics, Agricultural University, Wrocław, Poland.
Hładyszowski
J
J
Pruchnik
H
H
Przestalski
S
S
D000818:Animals; D004912:Erythrocytes / Q000187:drug effects* / Q000502:physiology; D006461:Hemolysis; D007700:Kinetics; D007854:Lead / Q000494:pharmacology*; D009942:Organometallic Compounds / Q000494:pharmacology*; D009947:Organotin Compounds / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013552:Swine
D009942:Organometallic Compounds; D009947:Organotin Compounds; D007854:Lead