Trypanosoma cruzi stocks isolated from acute Chagas disease patients lead to lethal murine infection.
Ten Trypanosoma cruzi stocks recently isolated from patients in acute and chronic phases of Chagas disease were inoculated to susceptible (A/Sn) mice. The mice were inoculated with 10(4) trypomastigotes intraperitoneally and monitored for parasitaemia and mortality for up to 300 d. The results demonstrated that (i) T. cruzi stocks isolated from patients in the acute phase killed animals, while stocks from patients in the chronic phase did not; (ii) survival curves differed statistically among mice infected with lethal stocks, and (iii) parasite burden did not affect the mortality rate of mice.
Oliveira
E C
EC
Departamento de Parasitologia, Universidade Federal de Goiás, Goiânia, Brazil.
Stefani
M M
MM
Campos
D E
DE
Andrade
A L
AL
Silva
S A
SA
Rassi
A
A
Luquetti
A O
AO
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000818:Animals; D014355:Chagas Disease / Q000469:parasitology*; D002648:Child; D002908:Chronic Disease; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D051379:Mice; D008875:Middle Aged; D018512:Parasitemia / Q000469:parasitology*; D016019:Survival Analysis; D014349:Trypanosoma cruzi / Q000302:isolation & purification / Q000472:pathogenicity*