title: Effect of Brussels sprouts on oxidative DNA-damage in man.
abstract: The effect of consumption of Brussels sprouts on the excretion of 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) into human urine was investigated. Ten non-smoking volunteers (five males and five females) were randomly assigned to two groups. Five volunteers started on a diet of 300 g of glucosinolate-free vegetables whereas the other five consumed 300 g of Brussels sprouts per day. After 1 week dietary regimes were reversed. Levels of 8-oxodG in 24-h urine samples were measured by high-performance liquid chromatography. In four of five males a reduction in 8-oxodG was found, whereas in the fifth male the 8-oxodG excretion was high in the control period and was even much higher in the sprouts period. In females no effect of consumption of Brussels sprouts on excretion of 8-oxodG was found. Our previous and present findings support the results of epidemiologic studies that consumption of brassica vegetables may diminish cancer risk.
authors.affiliation: TNO Nutrition and Food Research Institute, Zeist, The Netherlands. verhagen@voeding.tno.nl
authors.forename: H
authors.initials: H
authors.lastname: Verhagen
authors.forename: A
authors.initials: A
authors.lastname: de Vries
authors.forename: W A
authors.initials: WA
authors.lastname: Nijhoff
authors.forename: A
authors.initials: A
authors.lastname: Schouten
authors.forename: G
authors.initials: G
authors.lastname: van Poppel
authors.forename: W H
authors.initials: WH
authors.lastname: Peters
authors.forename: H
authors.initials: H
authors.lastname: van den Berg
mesh_terms: D000080242:8-Hydroxy-2'-Deoxyguanosine; D002851:Chromatography, High Pressure Liquid; D018592:Cross-Over Studies; D004249:DNA Damage; D003849:Deoxyguanosine / Q000031:analogs & derivatives* / Q000652:urine; D004032:Diet; D005260:Female; D006801:Humans; D008297:Male; D010084:Oxidation-Reduction; D012737:Sex Factors; D014675:Vegetables
chemical_list: D000080242:8-Hydroxy-2'-Deoxyguanosine; D003849:Deoxyguanosine