title: Relationship between hepatic blood flow, liver tests, haemodynamic values and clinical characteristics in patients with chronic liver disease.
abstract: Although hepatic blood flow (HBF) has been measured in patients with liver disease for many years, the results of these studies have not provided clear information concerning the usefulness of this measurement. Hepatic blood flow was measured in 392 patients with either cirrhosis (n = 356) or hepatic fibrosis (n = 36). The control group included 59 subjects with normal liver architecture. Hepatic clearance of indocyanine green (ICG) was markedly reduced in patients with cirrhosis and hepatic fibrosis compared with controls (182 +/- 5, 276 +/- 22 and 421 +/- 25 mL/min, respectively). In patients with cirrhosis, ICG clearance and extraction were significantly correlated, but were not correlated to HBF. Although HBF did not differ between patients with cirrhosis and controls (1.26 +/- 0.04 vs 1.35 +/- 0.07 L/min, respectively), patients with hepatic fibrosis had lower HBF (1.04 +/- 0.07 L/min; P < 0.05). In patients with cirrhosis, no correlation was observed between HBF and cardiac output, mean arterial pressure, azygos blood flow, the hepatic venous pressure gradient or Pugh's score. However, a significant difference in HBF was observed in patients with and without hepatic encephalopathy (1.00 +/- 0.09 vs 1.28 +/- 0.03 L/min, respectively; P < 0.05). In conclusion, the present study shows that, in patients with cirrhosis, HBF is normal and is not related to other haemodynamic values or liver tests. These results discourage the measurement of HBF in the evaluation of patients with cirrhosis.
authors.affiliation: Laboratoire d'Hémodynamique Splanchnique, Unité de Recherches de Physiopathologie Hépatique (INSERM U-24), Hôpital Beaujon, Clichy, France.
authors.forename: A
authors.initials: A
authors.lastname: Gadano
authors.forename: A
authors.initials: A
authors.lastname: Hadengue
authors.forename: F
authors.initials: F
authors.lastname: Vachiery
authors.forename: R
authors.initials: R
authors.lastname: Moreau
authors.forename: P
authors.initials: P
authors.lastname: Sogni
authors.forename: T
authors.initials: T
authors.lastname: Soupison
authors.forename: S
authors.initials: S
authors.lastname: Yang
authors.forename: S
authors.initials: S
authors.lastname: Cailmail
authors.forename: D
authors.initials: D
authors.lastname: Lebrec
mesh_terms: D000368:Aged; D002908:Chronic Disease; D004396:Coloring Agents; D005260:Female; D006439:Hemodynamics; D006801:Humans; D007208:Indocyanine Green; D008099:Liver / Q000503:physiopathology*; D008102:Liver Circulation; D008103:Liver Cirrhosis / Q000503:physiopathology*; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D012016:Reference Values
chemical_list: D004396:Coloring Agents; D007208:Indocyanine Green