title: Cobalt-55 positron emission tomography in ischemic stroke.
abstract: After acute cerebral stroke, the (peri-) infarct tissue is characterized by calcium (Ca)-mediated neuronal damage and inflammatory processes. Monitoring Ca-mediated damage using the isotope cobalt-55 (Co) as a Ca-tracer may enable PET-imaging of this tissue. Since the fate of (peri-) infarct tissue determines clinical outcome, Co-PET may have prognostic value in stroke. Six stroke patients were examined with Co-PET, MRI and a middle cerebral artery (mca) stroke scale (Orgogozo). In every patient, specific Co-accumulation in the appropriate brain region was seen, irrespective of the integrity of the blood-brain barrier. This pilot study suggests Co-PET as a diagnostic tool in stroke, which may provide additional information on the clinical outcome. Validation of method in larger patient series is necessary.
authors.affiliation: Department of Neurology, Groningen University Hospital, The Netherlands.
authors.forename: H M
authors.initials: HM
authors.lastname: Jansen
authors.forename: A M
authors.initials: AM
authors.lastname: Paans
authors.forename: A M
authors.initials: AM
authors.lastname: vd Vliet
authors.forename: L
authors.initials: L
authors.lastname: Veenma-van der Duin
authors.forename: C J
authors.initials: CJ
authors.lastname: Bolwijn-Meijer
authors.forename: J
authors.initials: J
authors.lastname: Pruim
authors.forename: A T
authors.initials: AT
authors.lastname: Willemsen
authors.forename: E J
authors.initials: EJ
authors.lastname: Franssen
authors.forename: J M
authors.initials: JM
authors.lastname: Minderhoud
authors.forename: J
authors.initials: J
authors.lastname: Korf
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001812:Blood-Brain Barrier / Q000502:physiology; D001925:Brain Damage, Chronic / Q000000981:diagnostic imaging* / Q000503:physiopathology; D001931:Brain Mapping; D015220:Calcium Channels / Q000502:physiology*; D016893:Carotid Stenosis / Q000000981:diagnostic imaging / Q000503:physiopathology; D002540:Cerebral Cortex / Q000098:blood supply / Q000000981:diagnostic imaging; D002544:Cerebral Infarction / Q000000981:diagnostic imaging* / Q000503:physiopathology; D003037:Cobalt Radioisotopes; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D012039:Regional Blood Flow / Q000502:physiology; D014022:Tissue Survival / Q000502:physiology; D014055:Tomography, Emission-Computed / Q000379:methods*
chemical_list: D015220:Calcium Channels; D003037:Cobalt Radioisotopes