[Vascularization of the human embryonic neocortex in the rat anterior chamber under cyclosporine A immunosuppression].
Fragments of 9 weeks hyman embryo neocortex were grafted into the rat eye anterior chamber. To prevent rejection cyclosporin A was introduced to the animals. Vascular network forming in transplants was studied for 5 weeks 3 days endothelial buds from the iris vessels appeared in transplants. After 10 days capillaries with erythrocytes appeared in the graft on the border with iris. 3 weeks later vascular network achieved its maximal development, occupying almost the entire graft thickness. The vessels developed diverged from the norm: they had variceal widenings, and focal distribution with significant non-vascular gaps.
Puchkov
V F
VF
Otellin
V A
VA
Smirnov
E B
EB
D000818:Animals; D000867:Anterior Chamber; D016380:Brain Tissue Transplantation / Q000473:pathology; D002540:Cerebral Cortex / Q000098:blood supply* / Q000196:embryology / Q000637:transplantation*; D016572:Cyclosporine / Q000494:pharmacology*; D016332:Fetal Tissue Transplantation / Q000473:pathology; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors; D016042:Transplantation, Heterotopic / Q000473:pathology
D007166:Immunosuppressive Agents; D016572:Cyclosporine
Vaskuliarizatsiia neokorteksa émbrionov cheloveka v peredneĭ kamere glaza krysy v usloviiakh immunosupressii tsiklosporinom A.