title: Contrasting patterns of nucleotide sequence variation at the glucose dehydrogenase (Gld) locus in different populations of Drosophila melanogaster.
abstract: We have analyzed nucleotide sequence variation at the Glucose dehydrogenase (Gld) locus from four populations of Drosophila melanogaster from four continents. All four population samples show a significant reduction in silent variation compared to the neutral expectation. The levels of silent variation across all four populations are consistent with the predictions of the background selection model; however, Zimbabwe has a remarkably low level of variation. In the face of dramatically reduced silent polymorphism, an amino acid variant, leading to the common allozyme polymorphism at Gld, remains in low to intermediate frequency in all non-African samples. In the Chinese population sample, the ratio of replacement to silent variation is significantly elevated compared to the neutral expectation. The difference in patterns of variation across these population samples suggests that selection on Gld (or the Gld region) has been different in the Chinese population than in the other three.
authors.affiliation: Section of Genetics and Development, Cornell University, Ithaca, NY14853, USA. mth3@cornell.edu
authors.forename: M T
authors.initials: MT
authors.lastname: Hamblin
authors.forename: C F
authors.initials: CF
authors.lastname: Aquadro
mesh_terms: D000818:Animals; D001483:Base Sequence; D002681:China; D004331:Drosophila melanogaster / Q000235:genetics*; D004484:Ecuador; D005260:Female; D005787:Gene Frequency; D014644:Genetic Variation; D005828:Genetics, Population; D042843:Glucose 1-Dehydrogenase; D005948:Glucose Dehydrogenases / Q000235:genetics*; D006239:Haplotypes / Q000235:genetics; D008297:Male; D008969:Molecular Sequence Data; D009657:North Carolina; D018807:Polymorphism, Single-Stranded Conformational; D012641:Selection, Genetic; D013045:Species Specificity; D015030:Zimbabwe
chemical_list: D005948:Glucose Dehydrogenases; D042843:Glucose 1-Dehydrogenase