Structural studies and synthetic applications of Baeyer-Villiger monooxygenases.
Baeyer-Villiger monooxygenases (BVMOs) are enzymes able to perform highly regio-plus steroselective nucleophilic and electrophilic biooxygenations on various substrates. The resultant chiral products (lactones and sulfoxides) can be valuable for the chemoenzymatic synthesis of a wide range of useful compounds. Recent studies have provided a number of alternative active-site models that attempt to explain the exquisite and unusual selectivity of BVMOs. This article reviews some of the established applications, and considers the merits of the various predictive models.
Willetts
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Department of Biological Sciences, University of Exeter, Devon, UK. A.J.Willetts@exeter.ac.uk
D000595:Amino Acid Sequence; D001665:Binding Sites; D005420:Flavoproteins / Q000737:chemistry* / Q000378:metabolism; D007700:Kinetics; D046911:Macromolecular Substances; D006899:Mixed Function Oxygenases / Q000737:chemistry* / Q000378:metabolism*; D008969:Molecular Sequence Data; D009243:NAD / Q000378:metabolism; D009249:NADP / Q000378:metabolism; D010105:Oxygenases / Q000737:chemistry* / Q000378:metabolism*; D013379:Substrate Specificity
D005420:Flavoproteins; D046911:Macromolecular Substances; D009243:NAD; D009249:NADP; D006899:Mixed Function Oxygenases; D010105:Oxygenases; C019961:cyclohexanone oxygenase