title: Effects of RP 55778, a tumor necrosis factor alpha synthesis inhibitor, on antiviral activity of dideoxynucleosides.
abstract: Tumor necrosis factor alpha (TNF-alpha) is overexpressed during human immunodeficiency virus (HIV) infection. RP 55778, a TNF-alpha synthesis inhibitor, decreases HIV replication in monocytes/macrophages. Therapeutic use of RP 55778 in vivo, like that of other biological response modifiers, would theoretically require association with dideoxynucleosides. We have evaluated here the combinatory effects of zidovudine (AZT) or dideoxyinosine (ddI) and RP 55778. This TNF-alpha inhibitor antagonizes the antiviral effects of both dideoxynucleosides, especially AZT. The more favorable anti-HIV activity of ddI in resting cells may explain these unequal degrees of antagonism.
authors.affiliation: Service de Neurovirologie, CEA, DSV/DRM/SSA, IPSC, Fontenay aux Roses, France. clayette@dsvidf.cea.fr
authors.forename: P
authors.initials: P
authors.lastname: Clayette
authors.forename: N
authors.initials: N
authors.lastname: Dereuddre-Bosquet
authors.forename: M
authors.initials: M
authors.lastname: Martin
authors.forename: P
authors.initials: P
authors.lastname: Fretier
authors.forename: D
authors.initials: D
authors.lastname: Dormont
mesh_terms: D019380:Anti-HIV Agents / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D015224:Dideoxynucleosides / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D015497:HIV-1 / Q000187:drug effects*; D006801:Humans; D008826:Microbial Sensitivity Tests; D011725:Pyridines / Q000494:pharmacology*; D013844:Thiazoles / Q000494:pharmacology*; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors* / Q000096:biosynthesis*; D014779:Virus Replication / Q000187:drug effects; D015215:Zidovudine / Q000037:antagonists & inhibitors / Q000494:pharmacology
chemical_list: D019380:Anti-HIV Agents; D015224:Dideoxynucleosides; D011725:Pyridines; D013844:Thiazoles; D014409:Tumor Necrosis Factor-alpha; D015215:Zidovudine; C052520:3-(3-pyridinyl)-1H,3H-pyrrolo(1,2-c)thiazole-7-carboxamide