Effect of human milk prostaglandins and lactoferrin on respiratory syncytial virus and rotavirus.
The effect of lactoferrin and prostaglandins E and F2 alpha on the growth of rotavirus and respiratory syncytial virus in cell culture was investigated. Lactoferrin inhibited the growth of respiratory syncytial virus at a concentration tenfold lower than that normally present in human milk. The prostaglandins had no effect on either virus growth, even at a concentration of 100-fold more than that found in human milk. Lactoferrin may have some antiviral properties in human milk in addition to its known antibacterial functions.
Grover
M
M
School of Microbiology, Latrobe University, Bundoora, Victoria, Australia.
Giouzeppos
O
O
Schnagl
R D
RD
May
J T
JT
D000818:Animals; D006801:Humans; D066298:In Vitro Techniques; D007781:Lactoferrin / Q000494:pharmacology*; D008892:Milk; D011453:Prostaglandins / Q000494:pharmacology*; D012136:Respiratory Syncytial Viruses / Q000187:drug effects*; D012401:Rotavirus / Q000187:drug effects*
D011453:Prostaglandins; D007781:Lactoferrin