Synaptic and non-synaptic plasticity between individual pyramidal cells in the rat hippocampus in vitro.
We report here two forms of activity-dependent plasticity of the transfer of neuronal information between pairs of monosynaptically coupled pyramidal cells. In a first part, we discuss the induction of long-term bidirectional changes in excitatory synaptic transmission following defined regimes of neuronal activity. In a second part, we provide evidence that the conditions in which the presynaptic action potential is elicited determine whether it will successfully propagate along the presynaptic axon.
Debanne
D
D
Brain Research Institute, Zurich, Switzerland.
Gähwiler
B H
BH
Thompson
S M
SM
D000818:Animals; D001640:Bicuculline / Q000494:pharmacology; D002478:Cells, Cultured; D005071:Evoked Potentials / Q000187:drug effects; D006624:Hippocampus / Q000502:physiology*; D066298:In Vitro Techniques; D009473:Neuronal Plasticity; D017966:Pyramidal Cells / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D018091:Receptors, AMPA / Q000502:physiology; D016194:Receptors, N-Methyl-D-Aspartate / Q000502:physiology; D013569:Synapses / Q000187:drug effects / Q000502:physiology*; D009435:Synaptic Transmission / Q000187:drug effects
D018091:Receptors, AMPA; D016194:Receptors, N-Methyl-D-Aspartate; D001640:Bicuculline