Bovine viral diarrhoea virus infection in bone marrow of experimentally infected calves.
Colostrum-deprived calves were inoculated with either a field isolate of bovine viral diarrhoea virus (BVDV) containing cytopathogenic (CP) and noncytopathogenic (NCP) biotypes or with only the NCP biotype. Paraffin wax-embedded sections of bone marrow from these calves, examined by means of an immunoperoxidase method, showed BVDV antigen in megakaryocytes and myeloid cells. Infection of such cells may play a role in the pathogenesis of thrombocytopenia, leucopenia and neutropenia, as reported in cattle infected with BVDV.
Spagnuolo
M
M
Veterinary Sciences Division, Department of Agriculture for Northern Ireland, Belfast, Northern Ireland.
Kennedy
S
S
Foster
J C
JC
Moffett
D A
DA
Adair
B M
BM
D000208:Acute Disease; D000284:Administration, Oral; D000818:Animals; D000956:Antigens, Viral / Q000276:immunology; D001853:Bone Marrow / Q000276:immunology / Q000473:pathology / Q000821:virology*; D001912:Bovine Virus Diarrhea-Mucosal Disease / Q000276:immunology / Q000473:pathology / Q000821:virology*; D002417:Cattle; D001908:Diarrhea Viruses, Bovine Viral / Q000276:immunology / Q000302:isolation & purification; D007442:Intubation, Intratracheal
D000956:Antigens, Viral