Gender differences in cortical glucose metabolism in Alzheimer's disease and normal aging.
Male Alzheimer's disease patients, studied with 18-fluoro-2-deoxyglucose positron emission tomography while performing a verbal memory test, showed a right-greater-than-left asymmetry of cortical metabolism that tended to be greater than that in healthy, age-matched control subjects. This asymmetry was absent in female patients, preliminarily suggesting a propensity for left hemispheric involvement in the Alzheimer's disease process in males.
Siegel
B V
BV
Department of Psychiatry, University of California, Irvine, USA.
Shihabuddin
L
L
Buchsbaum
M S
MS
Starr
A
A
Haier
R J
RJ
Valladares Neto
D C
DC
D000368:Aged; D000375:Aging; D000544:Alzheimer Disease / Q000000981:diagnostic imaging / Q000378:metabolism*; D002540:Cerebral Cortex / Q000000981:diagnostic imaging / Q000378:metabolism*; D005260:Female; D007839:Functional Laterality; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D012737:Sex Factors; D014055:Tomography, Emission-Computed
D005947:Glucose