title: A t(9;11) translocation in childhood acute mixed leukemia.
abstract: We present the case of a child with acute lymphoid leukemia (ALL) who was morphologically classified as FAB L1 (PAS and peroxidase were negative). Remission was achieved with an ALL-type protocol (GBTLI). Five months after the discontinuation of therapy, the patient presented mixed leukemia (CD10, CD19, CD13 and CD33 were positive) with t (9;11) (p21;q23) translocation. Unfortunately, as cytogenetic and immunophenotype studies were not performed at diagnosis, two possibilities could be considered for the relapse; secondary mixed leukemia with clonal chromosome changes, or mixed leukemia from the beginning.
authors.affiliation: Department of Hematology, Escola Paulista de Medicina, São Paulo, Brazil.
authors.forename: M L
authors.initials: ML
authors.lastname: Chauffaille
authors.forename: M
authors.initials: M
authors.lastname: Yamamoto
authors.forename: V
authors.initials: V
authors.lastname: Odone Filho
authors.forename: M T
authors.initials: MT
authors.lastname: Almeida
authors.forename: P
authors.initials: P
authors.lastname: Maluf Júnior
authors.forename: L M
authors.initials: LM
authors.lastname: Cristofani
authors.forename: J
authors.initials: J
authors.lastname: Kerbauy
authors.forename: S C
authors.initials: SC
authors.lastname: Raimondi
mesh_terms: D002648:Child; D006801:Humans; D007621:Karyotyping; D015456:Leukemia, Biphenotypic, Acute / Q000235:genetics*; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics*; D014178:Translocation, Genetic