title: Comparison of in vivo red cell survival of donations collected by Haemonetics MCS versus conventional collection.
abstract: The Haemonetics Multicomponents System (MCS) cell separator allows concurrent donation of red cells in addition to platelets and/or plasma, thus increasing the versatility of apheresis donations. In vivo survival of autologous red cells obtained by MCS was compared with red cells collected conventionally. In this cross-over controlled study, five male volunteers donated one unit of red cells by MCS and one unit of whole blood by the conventional manual method, 3 months apart. After storing donations in SAG-M for 35 days under standard conditions, radioactive (51Cr)-labelled autologous red cells were injected into each donor. The post-transfusion recovery (PTR) of red cells at 24 and 48 h did not show any significant difference between red cells obtained manually and by MCS, indicating that processing differences have no detrimental effects on red cell survival.
authors.affiliation: North London Blood Centre, Colindale, UK.
authors.forename: F
authors.initials: F
authors.lastname: Regan
authors.forename: P
authors.initials: P
authors.lastname: Teesdale
authors.forename: S
authors.initials: S
authors.lastname: Garner
authors.forename: T
authors.initials: T
authors.lastname: Callaghan
authors.forename: M
authors.initials: M
authors.lastname: Brennan
authors.forename: M
authors.initials: M
authors.lastname: Contreras
mesh_terms: D001782:Blood Donors; D001793:Blood Preservation; D001800:Blood Specimen Collection / Q000379:methods*; D002469:Cell Separation / Q000295:instrumentation / Q000379:methods; D002470:Cell Survival; D017707:Erythrocyte Transfusion; D006801:Humans; D008297:Male