title: Bik and Bak induce apoptosis downstream of CrmA but upstream of inhibitor of apoptosis.
abstract: Recent studies have identified a number of cell death pathway components. In this study, we describe the role that two such components, Bik and Bak, play in initiating the apoptotic program. These Bcl-2 family members engage the death pathway downstream of the block imposed by the serpin CrmA, but upstream of the block initiated by cellular inhibitors of apoptosis, which are a family of molecules characterized by a conserved baculovirus inhibitor of apoptosis repeat motif. Distal death pathway components activated by Bik and Bak are similar to those activated by the CD-95 (Fas/Apo1) and tumor necrosis factor death receptors.
authors.affiliation: Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109, USA.
authors.forename: K
authors.initials: K
authors.lastname: Orth
authors.forename: V M
authors.initials: VM
authors.lastname: Dixit
mesh_terms: D017209:Apoptosis / Q000187:drug effects / Q000235:genetics; D051017:Apoptosis Regulatory Proteins; D053179:Caspase 7; D020169:Caspases; D003546:Cysteine Endopeptidases / Q000378:metabolism; D015853:Cysteine Proteinase Inhibitors / Q000494:pharmacology*; D004789:Enzyme Activation; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins; D008565:Membrane Proteins / Q000378:metabolism*; D024101:Mitochondrial Proteins; D008954:Models, Biological; D011506:Proteins / Q000378:metabolism*; D015843:Serpins / Q000235:genetics / Q000378:metabolism*; D014407:Tumor Cells, Cultured; D014764:Viral Proteins / Q000494:pharmacology*; D050998:bcl-2 Homologous Antagonist-Killer Protein
chemical_list: D051017:Apoptosis Regulatory Proteins; C494772:BAK1 protein, human; C096820:BIK protein, human; D015853:Cysteine Proteinase Inhibitors; D051034:Inhibitor of Apoptosis Proteins; D008565:Membrane Proteins; D024101:Mitochondrial Proteins; D011506:Proteins; D015843:Serpins; D014764:Viral Proteins; D050998:bcl-2 Homologous Antagonist-Killer Protein; C086430:inhibitor of apoptosis, Nucleopolyhedrovirus; C074641:interleukin-1beta-converting enzyme inhibitor; C505520:CASP7 protein, human; D053179:Caspase 7; D020169:Caspases; D003546:Cysteine Endopeptidases