Production of [11C]CH3I by single pass reaction of [11C]CH4 with I2.
We report a single pass gas phase route to [11C]CH3I based on production of I from I2 at elevated temperature. I abstracts H from CH4 to yield CH3, which reacts with I2 to form CH3I. A fiber optic spectrometer was used to measure the I2 vapor concentration. [11C]CH3I yield increased with I2 concentration until excessive amounts of condensed I2 began to trap the 11C. The yield of [11C]CH3I was > 50% from [11C]CH4I; its specific activity was 12,000 Ci/mmole. The synthesis takes only 4 min after 11CH4 production and can be repeated without system cleanup.
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J M
JM
Imaging Research Laboratory, UW Medical Center University of Washington, Seattle 98195-6004, USA. jeanne@u.washington.edu
Krohn
K A
KA
Clark
J C
JC
D002250:Carbon Radioisotopes; D006847:Hydrocarbons, Iodinated / Q000138:chemical synthesis* / Q000737:chemistry
D002250:Carbon Radioisotopes; D006847:Hydrocarbons, Iodinated; C014055:methyl iodide