Proof that green tea tannin suppresses the increase in the blood methylguanidine level associated with renal failure.
The effects of a green tea tannin mixture and its individual tannin components on methylguanidine were examined in rats with renal failure. The green tea tannin mixture caused a dose-dependent decrease in methylguanidine, a substance which accumulates in the blood with the progression of renal failure. Among individual tannin components, the effect was most conspicuous with (-)-epigallocatechin 3-O-gallate and (-)-epicatechin 3-O-gallate, while other components not linked to gallic acid showed only weak effects. Thus, the effect on methylguanidine was found to vary among different types of tannin.
Yokozawa
T
T
Research Institute for Wakan-Yaku, Toyama Medical and Pharmaceutical University, Japan.
Dong
E
E
Oura
H
H
D000225:Adenine; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D004305:Dose-Response Relationship, Drug; D008297:Male; D008760:Methylguanidine / Q000097:blood*; D051381:Rats; D017208:Rats, Wistar; D051437:Renal Insufficiency / Q000097:blood* / Q000139:chemically induced; D013634:Tannins / Q000737:chemistry / Q000494:pharmacology*; D013662:Tea / Q000737:chemistry*
D013634:Tannins; D013662:Tea; D008760:Methylguanidine; D000225:Adenine