title: [A long-term histological prognosis after IFN therapy for chronic hepatitis C].
abstract: In 72 chronic hepatitis C patients treated with IFN, liver biopsies were performed before and after IFN treatment, and histological changes were examined. In complete responders, the grading score improved significantly since 6-mo after IFN treatment, and the staging score improved significantly since 12-mo after IFN treatment. In long-term responders underwent a following liver biopsy 4-5 yr after IFN treatments; 5 had normal liver histology. In partial responders, both the grading and staging score did not improve significantly. But, in the cases who had sustained normalization of ALT levels after IFN treatment, both the grading and staging score improved after treatment. In non-responders, both the grading and staging score did not improve significantly.
authors.affiliation: Department of Gastroenterology, Kanto-Teishin Hospital.
authors.forename: M
authors.initials: M
authors.lastname: Terada
authors.forename: F
authors.initials: F
authors.lastname: Ikegami
authors.forename: M
authors.initials: M
authors.lastname: Oota
authors.forename: T
authors.initials: T
authors.lastname: Ooyama
authors.forename: S
authors.initials: S
authors.lastname: Sezai
authors.forename: M
authors.initials: M
authors.lastname: Ito
authors.forename: Y
authors.initials: Y
authors.lastname: Sakurai
authors.forename: K
authors.initials: K
authors.lastname: Kamisaka
authors.forename: T
authors.initials: T
authors.lastname: Abe
authors.forename: S
authors.initials: S
authors.lastname: Takasu
authors.forename: Y
authors.initials: Y
authors.lastname: Tanaka
mesh_terms: D001706:Biopsy; D002908:Chronic Disease; D005260:Female; D006526:Hepatitis C / Q000473:pathology / Q000628:therapy*; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000627:therapeutic use*; D008099:Liver / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011994:Recombinant Proteins
chemical_list: D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins