Presence of papillomavirus infections in genital lesions of women in Romania.
This study is aimed at establishing the presence of HPV infection in Romania, in women with various benign or malignant anogenital lesions. A number of 76 tissue samples were investigated by nucleic acid hybridization in the dot-blot techniques for identifying the HPVs presence and their serotypes and 35 sera were tested by the immunodot-blot technique in order to detect the presence of antiHPV16 E6 and E7 proteins antibodies. The results obtained suggest the incidence of HPV16 infection is high not only in persons with different tumours or other anogenital lesions (approximately 585), but also in apparently healthy women (3 of 4 cases).
Stoian
M
M
Stefan S. Nicolau Institute of Virology, Bucharest, Romania.
Anton
G
G
Achim
R
R
Repanovici
R
R
D000914:Antibodies, Viral / Q000097:blood; D000956:Antigens, Viral / Q000276:immunology; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D005831:Genital Diseases, Female / Q000453:epidemiology / Q000821:virology*; D006801:Humans; D009856:Oncogene Proteins, Viral / Q000276:immunology; D027383:Papillomaviridae / Q000145:classification / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*; D050725:Papillomavirus E7 Proteins; D030361:Papillomavirus Infections / Q000097:blood / Q000150:complications* / Q000453:epidemiology; D012097:Repressor Proteins; D012383:Romania / Q000453:epidemiology; D012703:Serotyping; D014412:Tumor Virus Infections / Q000097:blood / Q000150:complications* / Q000453:epidemiology
D000914:Antibodies, Viral; D000956:Antigens, Viral; D004279:DNA, Viral; C068651:E6 protein, Human papillomavirus type 16; D009856:Oncogene Proteins, Viral; D050725:Papillomavirus E7 Proteins; D012097:Repressor Proteins; C069119:oncogene protein E4, Human papillomavirus type 16; C059731:oncogene protein E7, Human papillomavirus type 16