title: Uterine carcinosarcomas: incidence and trends in management and survival.
abstract: Our study's aim was to determine the incidence of uterine sarcomas in New York City (NYC) and evaluate trends in frequency, treatment, and survival of carcinosarcomas in two Brooklyn hospitals. Population-based cancer registry data for 1976-1985 were used to calculate the incidence of uterine sarcomas in NYC women. Medical records and histology slides of carcinosarcomas at two central Brooklyn hospitals from 1960 to 1995 were reviewed. The incidence of uterine sarcomas in black and white women in NYC was 33.4 and 17.0 per million (P < 0.01). Among 97 women with carcinosarcomas diagnosed in 1960-1995, 75% were diagnosed preoperatively, 82% had a hysterectomy, and 45% of those in clinical stage I were upstaged. Predictors of mortality included the presence of extrauterine extension, deep myometrial invasion, vascular space invasion, and gross residual disease, with only the first two being independent predictors of survival in a multivariate analysis. Adjunctive therapy shifted from radiation in 1960-1969 to cisplatin-based chemotherapy after 1980. In surgical stage III, survival increased significantly between 1960-1979 and 1980-1995, but improvement could not be ascribed to particular therapies. The incidence of uterine sarcomas in black women was twice that in white women. Surgical staging including omentectomy is recommended in the management of carcinosarcomas. Modern medical care may have improved the short-term prognosis of carcinosarcomas.
authors.affiliation: Department of Obstetrics and Gynecology, State University of New York-Health Science Center at Brooklyn, 11203, USA.
authors.forename: C D
authors.initials: CD
authors.lastname: Arrastia
authors.forename: R G
authors.initials: RG
authors.lastname: Fruchter
authors.forename: M
authors.initials: M
authors.lastname: Clark
authors.forename: M
authors.initials: M
authors.lastname: Maiman
authors.forename: J C
authors.initials: JC
authors.lastname: Remy
authors.forename: M
authors.initials: M
authors.lastname: Macasaet
authors.forename: E J
authors.initials: EJ
authors.lastname: Gates
authors.forename: T
authors.initials: T
authors.lastname: Di Maio
authors.forename: T
authors.initials: T
authors.lastname: Marzec
mesh_terms: D000328:Adult; D001741:Black or African American; D000368:Aged; D002296:Carcinosarcoma / Q000453:epidemiology / Q000401:mortality / Q000628:therapy; D004358:Drug Therapy / Q000639:trends*; D005260:Female; D006801:Humans; D007890:Leiomyosarcoma / Q000453:epidemiology / Q000401:mortality / Q000628:therapy; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009519:New York City / Q000453:epidemiology; D011379:Prognosis; D011878:Radiotherapy / Q000639:trends*; D012042:Registries; D013514:Surgical Procedures, Operative / Q000639:trends*; D015996:Survival Rate; D016896:Treatment Outcome; D014594:Uterine Neoplasms / Q000453:epidemiology / Q000401:mortality / Q000628:therapy; D044465:White People