Pregnancy associated diffuse malignant fibrous mesothelioma of peritoneum. Immunohistochemical studies of ectopic decidual reaction and concomitant myofibroblastic and mesothelial proliferations.
A case of diffuse proliferations in the peritoneum in a 24-year-old woman several months post partum has been reported. Multinodular growth of myofibroblastic cells without atypia was observed, which predominated and revealed a positive immunohistochemical reaction to muscle-specific actin and vimentin, and dispersed clusters of mesothelial cells showing a positive reaction to cytokeratin and vimentin, with moderate atypia and scarce mitotic figures. On cesarean section the greater omentum contained an ectopic decidua in the form of a nodule. Decidual cells, in part transforming into spindle-shaped cells, showed the presence of desmin. Multifocal proliferation of myofibroblasts, most probably of metaplastic type, concomitant with pregnancy-induced peritoneal deciduosis and diffuse progressive mesothelial proliferations has been identified.
Urbańczyk
K
K
Department of Clinical and Experimental Pathomorphology, Jagiellonian University Medical College, Kraków.
Hajduk
A
A
Stachura
J
J
D000328:Adult; D002828:Choristoma / Q000378:metabolism* / Q000473:pathology; D003656:Decidua / Q000737:chemistry* / Q000473:pathology; D004848:Epithelium / Q000378:metabolism / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008654:Mesothelioma / Q000737:chemistry* / Q000473:pathology; D010534:Peritoneal Neoplasms / Q000737:chemistry* / Q000473:pathology; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000378:metabolism* / Q000473:pathology