title: Outer membrane proteins and elastase of Pseudomonas aeruginosa after the postantibiotic effect induced by amikacin.
abstract: Postantibiotic effects were induced in three Pseudomonas aeruginosa strains after short-term treatment (30 min) with amikacin at suprainhibitory concentrations in the range of 0.6-1.2 h (2 x MIC) and of 3.0-4.4 h (4 x MIC). Significant suppression of P. aeruginosa elastase activity was found after treatment with amikacin at 4 x MIC concentration (to 10-69.2% of the control values); 2 x MIC was less effective. The profile of outer membrane proteins of P. aeruginosa was not changed after treatment with amikacin at both concentrations.
authors.affiliation: Institute of Preventive and Clinical Medicine, Bratislava, Slovak Republic.
authors.forename: A
authors.initials: A
authors.lastname: Hostacká
authors.forename: E
authors.initials: E
authors.lastname: Karelová
mesh_terms: D000583:Amikacin / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001425:Bacterial Outer Membrane Proteins / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D008826:Microbial Sensitivity Tests; D010196:Pancreatic Elastase / Q000187:drug effects*; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D001425:Bacterial Outer Membrane Proteins; D000583:Amikacin; D010196:Pancreatic Elastase