title: [The cholinesterase reactivity of the Komandor squid Berryteuthis magister. Substrates and organophosphorus inhibitors].
abstract: With the substrate inhibition analysis it has been shown that the one enzyme is responsible for the choline-esterase activity of optic ganglia tissue of Comandor squid Berryteuthis magister from different regions of Bering and Japanese seas. The kinetic parameters of the choline-esterase hydrolysis with 8 choline esters have been determined. It demonstrates the wide spectrum of the substrate specificity of Comandor squid choline-esterase. The antienzyme efficiency for 18 organophosphorus inhibitors (among them 7 compounds containing acetylene group) has been investigated. Also the new information about choline-esterase "structure-action" connection for Comandor squid has been obtained. The quantitative differences in the substrate specificity and reactivity for organophosphorus inhibitors of choline-esterases of Comandor and Pacific squids have been obtained. It has not succeeded to find the intraspecific differences for Comandor squid species from various living zones using the investigated effects.
authors.forename: E V
authors.initials: EV
authors.lastname: Rozengart
mesh_terms: D000818:Animals; D002800:Cholinesterase Inhibitors / Q000494:pharmacology*; D002802:Cholinesterases / Q000187:drug effects*; D049832:Decapodiformes / Q000187:drug effects / Q000201:enzymology*; D017952:Ganglia, Invertebrate / Q000187:drug effects / Q000201:enzymology; D017950:Ganglia, Sensory / Q000187:drug effects / Q000201:enzymology; D009943:Organophosphorus Compounds / Q000494:pharmacology*; D013045:Species Specificity; D013379:Substrate Specificity / Q000187:drug effects
chemical_list: D002800:Cholinesterase Inhibitors; D009943:Organophosphorus Compounds; D002802:Cholinesterases
vernacular_title: Reaktsionnaia sposobnost' kholinésteraz komandorskogo kal'mara Berryteuthis magister. Substraty i fosfororganicheskie ingibitory.