title: Impact of intrauterine growth restriction on neurodevelopmental and growth outcomes in very low birthweight infants.
abstract: The impact of intrauterine growth restriction (IUGR) in very low birthweight preterm infants weighing < or = 1250 g was determined by comparing longitudinal growth and neurodevelopmental outcome to an adjusted age of 36 months in 52 intrauterine growth restricted children, with 55 birthweight-matched and 56 gestational age-matched children. None of these children had chromosomal anomalies, congenital infections, or major congenital malformations. Gestational ages of intrauterine growth restricted, birthweight- and gestational age-matched infants were 30 (+/-3), 26 (+/-2), 29 (+/-2) weeks: birthweights were 842 (+/-232), 872 (+/-201) and 1094 (+/-142) g, respectively. Intrauterine growth restricted children had fewer complications during initial hospitalization (p < 0.05), and had lower weights and head circumferences at follow-up (p < 0.05). No significant differences were present in major neurodevelopmental disabilities between the intrauterine growth restricted and two comparison groups. Persistence of microcephaly was associated with adverse neurodevelopmental outcome.
authors.affiliation: Department of Pediatrics, University of Calgary, Alberta, Canada.
authors.forename: H
authors.initials: H
authors.lastname: Amin
authors.forename: N
authors.initials: N
authors.lastname: Singhal
authors.forename: R S
authors.initials: RS
authors.lastname: Sauve
mesh_terms: D000886:Anthropometry; D001034:Apgar Score; D002547:Cerebral Palsy / Q000209:etiology*; D005260:Female; D005317:Fetal Growth Retardation / Q000150:complications*; D005500:Follow-Up Studies; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D019102:Infant, Very Low Birth Weight; D008607:Intellectual Disability / Q000209:etiology*; D008297:Male; D008831:Microcephaly / Q000209:etiology*; D010468:Perceptual Disorders / Q000209:etiology*; D011446:Prospective Studies; D012737:Sex Factors