Therapeutic efficacy of obidoxime or HI-6 with atropine against intoxication with some nerve agents in mice.
1 The toxicity of pinacolyl methylphosphonofluoridate (soman, GD), cyclohexyl methylphosphonofluoridate (cyclohe xylsarin, GF) and 2-dimethylaminoethyl-(dimethylamido)-phosphonofluoridate (GV) and the therapeutic efficacy of two oximes (obidoxime and HI-6) in combination with atropine against mentioned nerve agents were evaluated in mice. 2 The 24-h i.m. LD50 of GD was 101 micrograms/kg (99.5-104.0), LD50 of GF was 170 micrograms/kg (151.0-190.0 and LD50 of GV was 25.2 micrograms/kg (23.0-27.7). 3 The efficacy of two oximes, obidoxime (15 and 30 mg/kg) or HI-6 (15 and 30 mg/kg) in combination with atropine (21 mg/kg) was tested. HI-6 was significantly more effective in reducing mortality than obidoxime following poisoning with all three nerve agents. 4 Higher doses of both oximes showed significantly more effective therapeutic efficacy against all nerve agents studied.
Kassa
J
J
Purkynĕ Military Medical Academy, Hradec Králové.
Bajgar
J
J
D000818:Animals; D000931:Antidotes / Q000627:therapeutic use*; D002619:Chemical Warfare Agents / Q000506:poisoning*; D002801:Cholinesterase Reactivators / Q000627:therapeutic use*; D005260:Female; D005739:Gas Poisoning / Q000188:drug therapy*; D051379:Mice; D009768:Obidoxime Chloride / Q000627:therapeutic use*; D062025:Organophosphate Poisoning; D009943:Organophosphorus Compounds; D010091:Oximes; D011726:Pyridinium Compounds / Q000627:therapeutic use*; D012524:Sarin / Q000031:analogs & derivatives / Q000506:poisoning; D012999:Soman / Q000506:poisoning
D000931:Antidotes; D002619:Chemical Warfare Agents; D002801:Cholinesterase Reactivators; D009943:Organophosphorus Compounds; D010091:Oximes; D011726:Pyridinium Compounds; C086875:2-dimethylaminoethyl-(dimethylamido)fluorophosphate; D009768:Obidoxime Chloride; D012999:Soman; D012524:Sarin; C022870:asoxime chloride