DNA gyrase as a drug target.
DNA gyrase is a remarkable enzyme, catalysing the seemingly complex reaction of DNA supercoiling. As gyrase is essential in prokaryotes, it is a good target for antibacterial agents. These agents have diverse chemical structures and interact with gyrase in a variety of ways.
Maxwell
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Dept of Biochemistry, University of Leicester, UK. ony@leicester.ac.uk
D003374:Coumarins / Q000494:pharmacology; D004250:DNA Topoisomerases, Type II / Q000737:chemistry; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005544:Forecasting; D015363:Quinolones / Q000494:pharmacology; D059005:Topoisomerase II Inhibitors
D003374:Coumarins; D004791:Enzyme Inhibitors; D015363:Quinolones; D059005:Topoisomerase II Inhibitors; D004250:DNA Topoisomerases, Type II