Two mosaic-YY males carrying asymmetric Y chromosomes.
Two patients were referred because of oligospermia and azospermia, respectively. Karyotypic analysis revealed two mosaic-YY males carrying asymmetric Y chromosomes. To our knowledge, no instance of double unequal Y chromosomes has been reported so far in human males. Results of fluorescent in situ hybridization (FISH) studies in spermatozoa from one of these patients revealed a significantly high number of hyperaploid spermatozoa.
Zelante
L
L
Servizio di Genetica Medica, IRCCS, Ospedale CSS San Giovanni Rotondo, Italy.
Dallapiccola
B
B
Calvano
S
S
Memeo
E
E
Gasparini
P
P
Simi
P
P
Rossi
S
S
Finelli
P
P
Rocchi
M
M
Archidiacono
N
N
D000328:Adult; D002869:Chromosome Aberrations; D003456:Cryptorchidism / Q000601:surgery; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D008297:Male; D009030:Mosaicism; D009845:Oligospermia / Q000235:genetics*; D011247:Pregnancy; D013094:Spermatozoa / Q000502:physiology; D013737:Testis / Q000473:pathology; D014998:Y Chromosome