Diagnosis and successful in utero treatment of a fetal goitrous hyperthyroidism caused by maternal Graves' disease. A case report.
A case of maternal treated Graves' disease associated with hyperthyroid fetal goiter is presented. Fetal goiter is diagnosed by ultrasound and hyperthyroidism is confirmed by fetal blood sampling. Fetal thyroid status is normalized by maternal carbamizole treatment whereas the mother is euthyroid with replacement therapy after subtotal thyroidectomy. Repeated funipuncture allows us to adjust the fetal treatment. The infant is euthyroid at birth. Pathogenesis, diagnosis and treatment of fetal thyrotoxicosis complicated with maternal Graves' disease are discussed.
Heckel
S
S
Department of Obstetrical Ultrasound and Fetal Medicine, Hôpital de Hautepierre, Strasbourg, France.
Favre
R
R
Schlienger
J L
JL
Soskin
P
P
D000328:Adult; D013956:Antithyroid Agents / Q000008:administration & dosage / Q000627:therapeutic use; D002231:Carbimazole / Q000008:administration & dosage / Q000627:therapeutic use; D005260:Female; D005312:Fetal Blood / Q000737:chemistry; D005315:Fetal Diseases / Q000000981:diagnostic imaging* / Q000188:drug therapy; D006042:Goiter / Q000000981:diagnostic imaging* / Q000188:drug therapy; D006111:Graves Disease / Q000150:complications* / Q000601:surgery; D006801:Humans; D006980:Hyperthyroidism / Q000097:blood / Q000175:diagnosis* / Q000188:drug therapy; D011247:Pregnancy; D011248:Pregnancy Complications / Q000601:surgery; D013965:Thyroidectomy; D016216:Ultrasonography, Prenatal
D013956:Antithyroid Agents; D002231:Carbimazole