title: Exercise capacity after His bundle ablation and rate response ventricular pacing for drug refractory chronic atrial fibrillation.
abstract: OBJECTIVE
  To evaluate exercise capacity of patients with chronic atrial fibrillation in whom His bundle ablation followed by ventricular rate response pacing (VVIR) was carried out because of drug refractoriness.
  
  
  METHODS
  Prospective study.
  
  
  METHODS
  25 consecutive patients, all with chronic symptomatic drug refractory atrial fibrillation, underwent His bundle ablation. Before this intervention all patients were on antiarrhythmic drugs to attain acceptable heart rate control and to relief symptoms.
  
  
  METHODS
  Exercise capacity, including measurements of VO2, was examined before and after a mean interval of seven months following His bundle ablation.
  
  
  RESULTS
  Exercise capacity after His bundle ablation increased from a mean of 109 (SD 49) W to 118 (46) W (P < 0.002), but VO2 at peak exercise did not change significantly. Maximum exercise capacity was achieved with a significantly lower maximum driven heart rate than the spontaneous heart rate before ablation.
  
  
  CONCLUSIONS
  Exercise capacity of patients who underwent His bundle ablation followed by VVIR pacing remained unchanged or improved during a mean follow up of seven months. Larger patient populations with longer follow up are necessary to examine determinants of improved exercise capacity.
authors.affiliation: Department of Cardiology, St Antonius Hospital, Nieuwegein, The Netherlands.
authors.forename: E M
authors.initials: EM
authors.lastname: Buys
authors.forename: N M
authors.initials: NM
authors.lastname: van Hemel
authors.forename: J C
authors.initials: JC
authors.lastname: Kelder
authors.forename: C A
authors.initials: CA
authors.lastname: Ascoop
authors.forename: P F
authors.initials: PF
authors.lastname: van Dessel
authors.forename: L
authors.initials: L
authors.lastname: Bakema
authors.forename: J H
authors.initials: JH
authors.lastname: Kingma
mesh_terms: D001281:Atrial Fibrillation / Q000503:physiopathology / Q000601:surgery* / Q000628:therapy; D002036:Bundle of His / Q000601:surgery*; D002304:Cardiac Pacing, Artificial; D017115:Catheter Ablation; D003131:Combined Modality Therapy; D005080:Exercise Test; D017079:Exercise Tolerance; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010138:Pacemaker, Artificial