A case of primary cutaneous cryptococcosis.
The case of a 77-year-old man in whom a large digital ulcer with undermined edges was due to cutaneous infection by Cryptococcus neoformans variety neoformans serotype D, probably following direct inoculation, is reported. Long-term steroid treatment for chronic obstructive pulmonary disease may have been a risk factor. A 12-day course of intravenous amphotericin B at a cumulative dose of 750 mg, followed by oral fluconazole at a daily dose of 600 mg for six weeks, resulted in healing of the skin lesion. Manifestations of primary cutaneous cryptococcosis in immunocompetent or immunocompromised patients are reviewed.
Vogelaers
D
D
Department of Internal Medicine, University Hospital Ghent, Belgium.
Petrovic
M
M
Deroo
M
M
Verplancke
P
P
Claessens
Y
Y
Naeyaert
J M
JM
Afschrift
M
M
D000284:Administration, Oral; D000368:Aged; D000666:Amphotericin B / Q000008:administration & dosage / Q000627:therapeutic use; D000935:Antifungal Agents / Q000008:administration & dosage / Q000627:therapeutic use; D003453:Cryptococcosis / Q000175:diagnosis* / Q000188:drug therapy; D003455:Cryptococcus neoformans; D003881:Dermatomycoses / Q000175:diagnosis* / Q000188:drug therapy; D005385:Fingers / Q000382:microbiology*; D015725:Fluconazole / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D016867:Immunocompromised Host; D008173:Lung Diseases, Obstructive / Q000150:complications / Q000188:drug therapy; D008297:Male; D013256:Steroids / Q000009:adverse effects / Q000627:therapeutic use
D000935:Antifungal Agents; D013256:Steroids; D000666:Amphotericin B; D015725:Fluconazole