[Effect of anthocyanins on human connective tissue metabolism in the human].
BACKGROUND
Diabetic retinopathy can lead to blindness. This is due to an abnormally increased synthesis of connective tissue in order to a) repair leaking capillaries and b) formation of new capillaries.


METHODS
Twelve adult diabetics were treated with 600 mg anthocyanosides per day for two months. Samples of gingiva tissue were taken before and after treatment. Incubated with radio-active labeled amino acids, the measure of radioactivity from different connective tissue extracts can show a changed protein biosynthesis activity.


RESULTS
The use of radio-active labeled amino acids show significant decrease of biosynthesis-activity of connective tissue especially polymeric collagen and structure-glycoproteins by anthocyanoside medication.


CONCLUSIONS
Anthocyanosides help to prevent diabetics from injuries caused by malfunction of synthesis-activities throughout normal diabetic medical treatment.
Boniface
R
R
Labor für Bindegewebsbiochemie, Medizinische Fakultät, Universität Paris, Val de Marne.
Robert
A M
AM
D000284:Administration, Oral; D000328:Adult; D000872:Anthocyanins / Q000008:administration & dosage*; D001485:Basement Membrane / Q000187:drug effects / Q000473:pathology; D001813:Blood-Retinal Barrier / Q000187:drug effects; D003238:Connective Tissue / Q000187:drug effects / Q000473:pathology; D003930:Diabetic Retinopathy / Q000188:drug therapy* / Q000473:pathology; D005109:Extracellular Matrix / Q000187:drug effects / Q000473:pathology; D005260:Female; D006025:Glycosaminoglycans / Q000378:metabolism*; D006801:Humans; D008297:Male
D000872:Anthocyanins; D006025:Glycosaminoglycans
Einfluss von Anthocyanen auf den Bindegewebsmetabolismus beim Menschen.