Therapeutic strategies in the prevention of acute renal failure.
The mechanisms involved and the potentially useful therapeutic strategies in the prevention of acute renal failure (ARF) are briefly reviewed. Factors mentioned are the role of calcium channel blockers, the antioxidant agents, heme oxygenase induction, and ferritin synthesis; and of substances with hemodynamic actions in ARF; such as endothelin, atrial natriuretic peptide, urodilatin, PAF antagonist, prostaglandins, diuretics, and dopamine. The loss of tubular epithelium polarity, the mechanisms involved in this process, and the usefulness of arginine-glycine-aspartic acid peptide and anti-ICAM antibodies in the prevention of tubular obstruction are also reviewed.
García
R E
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Department of Nephrology, A. Nef Hospital, Faculty of Medicine, Universidad de Valparaíso, Chile.
D058186:Acute Kidney Injury / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control*; D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D001685:Biological Factors / Q000627:therapeutic use*; D002118:Calcium / Q000378:metabolism; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000276:immunology; D007501:Iron / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000502:physiology
D000975:Antioxidants; D001685:Biological Factors; D002121:Calcium Channel Blockers; D017382:Reactive Oxygen Species; D018799:Intercellular Adhesion Molecule-1; D000255:Adenosine Triphosphate; D007501:Iron; D002118:Calcium