Lewis, secretor, and ABO phenotypes, and sulfomucin expression in gastric intestinal metaplasia.
The closely interrelated Lewis, secretor, and ABO phenotypes have long been linked to the risk of peptic ulcers and gastric cancer and may modulate the interaction between Helicobacter pylori and the gastric surface epithelium. We explored the association between the expression of sulfomucins in gastric intestinal metaplasia, a known marker of preneoplastic progression, and the expression of Lewis, secretor, and ABO phenotypes, in 523 subjects from Nariño, Colombia, and 856 subjects from northern Spain. In both study populations, Lewis (a+/b-) and nonsecretor phenotypes showed a significant positive association with the expression of sulfomucins (odds ratios, 2.4 and 2.6, respectively).
Torrado
J
J
Hospital Aránzazu, San Sebastián, Spain.
Ruiz
B
B
Garay
J
J
Cosme
A
A
Arenas
J I
JI
Bravo
J C
JC
Fontham
E
E
Correa
P
P
D000017:ABO Blood-Group System / Q000032:analysis*; D000293:Adolescent; D000328:Adult; D000368:Aged; D001706:Biopsy; D003105:Colombia; D003431:Cross-Cultural Comparison; D005260:Female; D005753:Gastric Mucosa / Q000473:pathology; D016481:Helicobacter Infections / Q000473:pathology; D016480:Helicobacter pylori; D006801:Humans; D007983:Lewis Blood Group Antigens / Q000032:analysis*; D008297:Male; D008679:Metaplasia; D008875:Middle Aged; D009077:Mucins / Q000032:analysis*; D010641:Phenotype; D011230:Precancerous Conditions / Q000473:pathology*; D012307:Risk Factors; D013030:Spain; D013274:Stomach Neoplasms / Q000473:pathology*
D000017:ABO Blood-Group System; D007983:Lewis Blood Group Antigens; D009077:Mucins; C012564:sulfomucin