Genetic markers in standardbred trotters susceptible to the rhabdomyolysis syndrome.
The equine rhabdomyolysis syndrome (RHA) is believed to be multifactorial in origin; and could be caused by an interaction between genetic and environmental factors. In order to analyse its genetic background an association study was undertaken. Two sample groups of Standardbreds (Stb) which had suffered from RHA were compared to the total population of Swedish Standardbred trotters using recorded polymorphic genetic markers. The results showed that gene frequencies for several markers in the RHA groups differed significantly from those estimated for the total population. A rhabdomyolysis risk group could be characterised using 4 or 5 genetic marker loci.
Collinder
E
E
Department of Medicine and Surgery, Swedish University of Agricultural Sciences, Uppsala, Sweden.
Lindholm
A
A
Rasmuson
M
M
D000483:Alleles; D000818:Animals; D005260:Female; D005787:Gene Frequency; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D006734:Horse Diseases / Q000453:epidemiology / Q000209:etiology / Q000235:genetics*; D006736:Horses; D008297:Male; D008957:Models, Genetic; D011110:Polymorphism, Genetic; D012206:Rhabdomyolysis / Q000453:epidemiology / Q000235:genetics / Q000662:veterinary*; D012307:Risk Factors; D013548:Sweden / Q000453:epidemiology; D013577:Syndrome
D005819:Genetic Markers