The dopamine D3 receptor antagonist, (+)-S 14297, blocks the cataleptic properties of haloperidol in rats.
In contrast to haloperidol, the selective dopamine D3 receptor antagonist, (+)-S 11566 [(+/-)-[7-(N,N-dipropylamino)-5,6,7,8-tetrahydro- naphtho(2,3b)dihydro,2,3-furanel]] and its active isomer, (+)-S 14297, induced neither catalepsy nor reduced conditioned avoidance responses in rats. (+)-S 11566 and (+)-S 14297 did, however, dose-dependently abolish the cataleptic actions of haloperidol. This action was expressed stereospecifically inasmuch as (-)-S 17777, the inactive distomer of (+)-S 14297, was ineffective. Further, the influence of haloperidol upon conditioned avoidance responses was not affected by (+)-S 14297. These data suggest that blockade of dopamine D3 receptors may inhibit the extrapyramidal but not-as based on the conditioned avoidance response paradigm-antipsychotic actions of neuroleptics.
Millan
M J
MJ
Centre de Recherches de Croissy, Department de Psychopharmacologie, Paris, France.
Gressier
H
H
Brocco
M
M
D015081:2-Naphthylamine / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D014150:Antipsychotic Agents / Q000633:toxicity*; D001362:Avoidance Learning / Q000187:drug effects; D002375:Catalepsy / Q000139:chemically induced / Q000503:physiopathology* / Q000517:prevention & control; D065127:Dopamine D2 Receptor Antagonists; D004305:Dose-Response Relationship, Drug; D005663:Furans / Q000494:pharmacology*; D006220:Haloperidol / Q000633:toxicity*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D050637:Receptors, Dopamine D3; D013237:Stereoisomerism
D014150:Antipsychotic Agents; D065127:Dopamine D2 Receptor Antagonists; C493595:Drd3 protein, rat; D005663:Furans; D050637:Receptors, Dopamine D3; C090812:7-(N,N-dipropylamino)-5,6,7,8-tetrahydronaphtho(2,3-b)dihydro-2,3-furan; D015081:2-Naphthylamine; D006220:Haloperidol