5-HT1A receptor binding sites in post-mortem brain samples from depressed suicides and controls.
5-HT1A receptor binding sites were measured, by saturation binding with [3H]8-OH-DPAT, in frontal and occipital cortex, hippocampus and amygdala obtained at post-mortem examination from suicide victims with a firm retrospective diagnosis of depression, and matched controls. The number of 5-HT1A binding sites did not differ significantly between suicides and controls, either in the total sample or when the suicides were divided on the basis of violence of death or recent antidepressant treatment.
Lowther
S
S
Department of Pharmacology and Clinical Pharmacology, St. George's Hospital Medical School, London, UK.
De Paermentier
F
F
Cheetham
S C
SC
Crompton
M R
MR
Katona
C L
CL
Horton
R W
RW
D000293:Adolescent; D000328:Adult; D000368:Aged; D000679:Amygdala / Q000187:drug effects / Q000473:pathology; D000928:Antidepressive Agents / Q000506:poisoning / Q000627:therapeutic use; D001921:Brain / Q000187:drug effects / Q000473:pathology*; D002423:Cause of Death; D002540:Cerebral Cortex / Q000187:drug effects / Q000473:pathology; D003866:Depressive Disorder / Q000473:pathology* / Q000523:psychology; D062787:Drug Overdose / Q000473:pathology; D005260:Female; D006624:Hippocampus / Q000187:drug effects / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011180:Postmortem Changes; D011985:Receptors, Serotonin / Q000032:analysis* / Q000187:drug effects; D044263:Receptors, Serotonin, 5-HT1; D013405:Suicide / Q000523:psychology*; D000092864:Suicide Prevention
D000928:Antidepressive Agents; D011985:Receptors, Serotonin; D044263:Receptors, Serotonin, 5-HT1