Biological effects of drug-loaded biodegradable membranes for guided bone regeneration.
The biological effects of drug-loaded biodegradable novel membrane for guided bone regeneration (GBR) was evaluated. The membranes were polyglycolic acid mesh coated with poly-L-lactic acid containing flurbiprofen, tetracycline or PDGF-BB. Porous structure was generated in the membranes by using a phase inversion method. The membrane was less toxic, nicely biodegradable and biocompatible for 8 wk after implantation in the dorsal skin of the rat. The drugs released from the membranes were shown to be effective for new bone formation. Tetracycline, flurbiprofen or PDGF-BB loaded membrane was markedly effective for osteoid tissue and new bone formation in the bony defect prepared in rat calvaria to compare with that by unloaded membrane. These results suggested that drug-loaded biodegradable barrier membrane might be a potential tool for GBR in periodontal therapy.
Chung
C P
CP
Department of Periodontology, College of Dentistry, Seoul National University, Korea.
Kim
D K
DK
Park
Y J
YJ
Nam
K H
KH
Lee
S J
SJ
D000704:Analysis of Variance; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000925:Anticoagulants / Q000494:pharmacology; D000077214:Becaplermin; D001673:Biodegradation, Environmental; D001861:Bone Regeneration / Q000187:drug effects*; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology; D005480:Flurbiprofen / Q000494:pharmacology; D048091:Guided Tissue Regeneration / Q000295:instrumentation*; D019344:Lactic Acid; D008567:Membranes, Artificial; D010982:Platelet-Derived Growth Factor / Q000494:pharmacology; D011091:Polyesters; D011108:Polymers; D020574:Proto-Oncogene Proteins c-sis; D051381:Rats; D017207:Rats, Sprague-Dawley; D012886:Skull; D018709:Statistics, Nonparametric; D013752:Tetracycline / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D000925:Anticoagulants; D016861:Cyclooxygenase Inhibitors; D008567:Membranes, Artificial; D010982:Platelet-Derived Growth Factor; D011091:Polyesters; D011108:Polymers; D020574:Proto-Oncogene Proteins c-sis; D000077214:Becaplermin; D019344:Lactic Acid; C033616:poly(lactide); D005480:Flurbiprofen; D013752:Tetracycline