title: Structure-activity relationship in the induction of chromosomal aberrations and spindle disturbances in Chinese hamster epithelial liver cells by regioisomeric phenanthrene quinones.
abstract: Four regioisomeric phenanthrene (PH) quinones (Q) were investigated for their ability to induce chromosomal damage and spindle disturbances. PH 1,4-Q and PH 1,2-Q induced structural as well as numerical chromosomal aberrations, whereas the isomers PH 9,10-Q and PH 3,4-Q were virtually inactive in this respect, However, all four compounds enhanced the frequency of c-mitoses.
authors.affiliation: European Centre for the Validation of Alternative Methods (ECVAM), J.R.C. Environmental Institute, Ispra (Va), Italy.
authors.forename: G
authors.initials: G
authors.lastname: Turchi
authors.forename: H R
authors.initials: HR
authors.lastname: Glatt
authors.forename: A
authors.initials: A
authors.lastname: Seidel
authors.forename: A
authors.initials: A
authors.lastname: Puliti
authors.forename: I
authors.initials: I
authors.lastname: Sbrana
mesh_terms: D000818:Animals; D002460:Cell Line; D002842:Chromatids / Q000187:drug effects; D002869:Chromosome Aberrations; D006224:Cricetinae; D003412:Cricetulus; D004848:Epithelium / Q000187:drug effects; D007536:Isomerism; D008099:Liver / Q000166:cytology / Q000187:drug effects*; D008940:Mitotic Index / Q000187:drug effects; D009153:Mutagens; D010616:Phenanthrenes / Q000633:toxicity*; D008941:Spindle Apparatus / Q000187:drug effects*; D013329:Structure-Activity Relationship
chemical_list: D009153:Mutagens; D010616:Phenanthrenes; C005399:9,10-phenanthrenequinone; C105961:3,4-phenanthrenequinone; C105959:1,4-phenanthrenequinone; C105960:1,2-phenanthrenequinone