Preclinical and clinical studies of a collagen membrane (Bio-Gide).
Membranes are used to guide the repopulation of defects by preferred cells and to achieve a specific healing effect. The collagen membrane studied, Bio-Gide, was developed particularly for periodontal, peri-implant applications or to improve the ossification of bone defects of any origin. Bio-Gide is a bilayer membrane; one compact and smooth layer is covered by a particularly dense film, designed to prevent the invasion of soft tissue in a membrane-protected bone defect. The other, rough side of Bio-Gide must be placed towards the bone defect in order to make bone ingrowth possible. As a prerequisite for its therapeutic use in humans, the collagen matrix must be devoid of major immunogenicity. The immunological response to the membrane material was analysed in rabbits. Later, a clinical prospective study provided information about the bone regeneration effect under the Bio-Gide membrane inserted in six patients selected at random. The immune response to the collagen membrane Bio-Gide and the bone healing was tested in these patients when undergoing oral surgery.
Schlegel
A K
AK
Klinik und Poliklinik für Kieferchirurgie, Ludwig Maximilians Universität, München, Germany.
Möhler
H
H
Busch
F
F
Mehl
A
A
D000818:Animals; D001672:Biocompatible Materials; D002417:Cattle; D003094:Collagen / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D008567:Membranes, Artificial; D008963:Molar / Q000601:surgery; D010012:Osteogenesis; D011817:Rabbits; D011897:Random Allocation; D015203:Reproducibility of Results; D013515:Surgery, Oral; D013552:Swine; D014945:Wound Healing
C106416:Bio-Gide; D001672:Biocompatible Materials; D008567:Membranes, Artificial; D003094:Collagen