[Study of anti-HIV activity of the yeast RNA-tilorone molecular complex].
Anti-HIV activity of the molecular complex forming during interaction between yeast RNA and tilorone was studied in vitro on the models of acute and chronic infection. Addition of this agent to the cells infected with HIV-1/IIIB and HIV-1/BRU decreased the virus reproduction controlled by assessing the viability of cells, syncytium production, and accumulation of p24 antigen in culture medium. The authors hypothesize that the detected anti-HIV effect is due to its capacity to produce type I interferon and direct antiviral action.
Karpov
A V
AV
Antonenko
S V
SV
Barbasheva
E V
EV
Spivak
N Ia
NIa
D019380:Anti-HIV Agents / Q000494:pharmacology*; D002460:Cell Line; D015497:HIV-1 / Q000187:drug effects / Q000502:physiology; D006801:Humans; D007369:Interferon Inducers / Q000494:pharmacology*; D012331:RNA, Fungal / Q000737:chemistry / Q000494:pharmacology*; D013994:Tilorone / Q000737:chemistry / Q000494:pharmacology*; D014779:Virus Replication / Q000187:drug effects
D019380:Anti-HIV Agents; D007369:Interferon Inducers; D012331:RNA, Fungal; D013994:Tilorone
Izuchenie anti-VICh-aktivnosti molekuliarnogo kompleksa drozhzhevaia RNK-tiloron.