A possible role of pre-existing IgM/IgG antibodies in determining immune response type.
On the basis of the data indicating the existence of two types of immuno-protection, namely macrophage-mediated and mast cell-basophil-mediated, it is argued that by reacting with potential pathogens, pre-existing IgM and IgG antibodies (both natural and induced by environmental microflora) might promote involvement of macrophages in the presentation process, favouring the generation of pathogen-specific T helper 1 (Th1), but not Th2, responses. Alternatively, the failure of these antibodies to effectively recognize pathogens might be associated with active involvement of pathogen-specific B cells in presenting Ag and, as a consequence, with the predominant development of Th2, rather than Th1, responses.
Seledtsov
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VI
Institute of Clinical Immunology, Novosibirsk, Russia.
Seledtsova
G V
GV
D000818:Animals; D017951:Antigen Presentation; D000947:Antigens, Helminth / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology; D006801:Humans; D007104:Immune Adherence Reaction; D007074:Immunoglobulin G / Q000276:immunology*; D007075:Immunoglobulin M / Q000276:immunology*; D008264:Macrophages / Q000276:immunology*; D008407:Mast Cells / Q000276:immunology*; D018448:Models, Immunological; D018417:Th1 Cells / Q000276:immunology*; D018418:Th2 Cells / Q000276:immunology*
D000947:Antigens, Helminth; D007074:Immunoglobulin G; D007075:Immunoglobulin M