title: Long-term effects of localized spinal radiation therapy on vertebral fractures and focal lesions appearance in patients with multiple myeloma.
abstract: The occurrence of new vertebral fractures and focal marrow lesions was determined and compared in irradiated and nonirradiated vertebrae of 12 patients with multiple myeloma (MM), prospectively followed using magnetic resonance imaging (MRI) of the thoraco-lumbar spine after localized spinal radiation therapy. During follow-up (mean 35 months), fractures appeared in 5% of irradiated vertebrae and in 20% of nonirradiated vertebrae: new focal lesions appeared in 4% of irradiated vertebrae and in 27% of nonirradiated vertebrae. This study demonstrates a beneficial long-term effect of localized radiation therapy, consisting of a reduced incidence of vertebral fractures and focal marrow lesions in irradiated vertebrae.
authors.affiliation: Department of Haematology, St Luc University Hospital, University of Louvain, Brussels, Belgium.
authors.forename: F
authors.initials: F
authors.lastname: Lecouvet
authors.forename: F
authors.initials: F
authors.lastname: Richard
authors.forename: B
authors.initials: B
authors.lastname: Vande Berg
authors.forename: J
authors.initials: J
authors.lastname: Malghem
authors.forename: B
authors.initials: B
authors.lastname: Maldague
authors.forename: J
authors.initials: J
authors.lastname: Jamart
authors.forename: A
authors.initials: A
authors.lastname: Ferrant
authors.forename: J L
authors.initials: JL
authors.lastname: Michaux
mesh_terms: D000368:Aged; D001855:Bone Marrow Diseases / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000473:pathology / Q000532:radiotherapy*; D011446:Prospective Studies; D013117:Spinal Cord Compression / Q000175:diagnosis; D016103:Spinal Fractures / Q000175:diagnosis / Q000532:radiotherapy*; D016896:Treatment Outcome