Troglitazone inhibits type 2KATP channel activity and depolarises tolbutamide-sensitive neurones in the rat ventromedial hypothalamus.
Patch-clamp recording techniques were used to examine the effect of troglitazone upon visually identified neurones contained in slices from the rat ventromedial hypothalamus. Bath application of 1-50 microM troglitazone depolarised tolbutamide-sensitive neurones in a poorly reversible manner. In outside-out patches, troglitazone inhibited KATP channel activity when added to the bath solution. It is concluded that troglitazone is a novel modulator of the type 2 KATP channel.
Lee
K
K
Parke Davis Neuroscience Research Centre, Cambridge University Forvie Site, UK.
Boden
P
P
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D002839:Chromans / Q000494:pharmacology*; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D008297:Male; D009474:Neurons / Q000737:chemistry / Q000187:drug effects* / Q000502:physiology; D009924:Organ Culture Techniques; D018408:Patch-Clamp Techniques; D026902:Potassium Channel Blockers; D051381:Rats; D017207:Rats, Sprague-Dawley; D013844:Thiazoles / Q000494:pharmacology*; D045162:Thiazolidinediones; D014044:Tolbutamide / Q000494:pharmacology*; D000077288:Troglitazone; D014697:Ventromedial Hypothalamic Nucleus / Q000737:chemistry* / Q000166:cytology / Q000187:drug effects
D002839:Chromans; D007004:Hypoglycemic Agents; D026902:Potassium Channel Blockers; D013844:Thiazoles; D045162:Thiazolidinediones; D000255:Adenosine Triphosphate; D014044:Tolbutamide; D000077288:Troglitazone