[Antioxidants and angiogenetic factor associated with age-related macular degeneration (exudative type)].
To confirm the hypothesis that antioxidants and angiogenetic factors may be associated with the development of age-related macular degeneration (exudative type), we compared serum levels of vitamins A, C, and E and carotinoid, zinc, selenium and b-FGF (basic-fibroblast growth factor) in 35 patients with age-related macular degeneration (exudative type) with the levels in 66 controls. The average serum zinc level was significantly lower in the patient group than in the control group. Serum vitamin E-alpha levels also tended to be lower. Most serum b-FGF levels were below the standard value in each group. Based on the above results, we conclude that subnormal levels of zinc and vitamin E may be associated with the development of age-related macular degeneration.
Ishihara
N
N
Department of Ophthalmology, Nihon University School of Medicine, Tokyo, Japan.
Yuzawa
M
M
Tamakoshi
A
A
D000368:Aged; D001205:Ascorbic Acid / Q000097:blood; D002338:Carotenoids / Q000097:blood; D016222:Fibroblast Growth Factor 2 / Q000097:blood; D006801:Humans; D008268:Macular Degeneration / Q000097:blood*; D008875:Middle Aged; D012643:Selenium / Q000097:blood; D014801:Vitamin A / Q000097:blood; D014810:Vitamin E / Q000097:blood; D015032:Zinc / Q000097:blood
D016222:Fibroblast Growth Factor 2; D014801:Vitamin A; D014810:Vitamin E; D002338:Carotenoids; D012643:Selenium; D015032:Zinc; D001205:Ascorbic Acid