title: Pharmacological modulation of the cardiovascular response to hypertonic NaCl injection in the anteroventral area of the rat brain third ventricle.
abstract: The anteroventral area of the rat brain third ventricle (AV3V) was stimulated by stereotaxically placed microinjections (1 microliter) of hypertonic 1.5 mol/l NaCl and the responses of mean arterial pressure (MAP) and heart rate (HR) were recorded. Previous injection of terazosin or propranolol (5.0 micrograms) into AV3V, 15 min before 1.5 mol/l NaCl microinjection, did not alter the cardiovascular response pattern induced by 1.5 mol/l NaCl. Prior AV3V treatment with ketanserin (1.0 microgram) significantly reduced (p < 0.01) the MAP and HR increase induced by 1.0 microliter of 1.5 mol/l NaCl without changing basal cardiovascular parameters. Prior AV3V treatment with losartan (10.0 micrograms) significantly reduced (p < 0.01) the hypertension and tachycardia induced by hypertonic NaCl administration. Thus, AV3V serotonin and angiotensin II-sensitive neurons may exert an excitatory role on blood pressure and HR involved with the sympathetic discharge produced by hypertonic NaCl stimulation.
authors.affiliation: Department of Pharmacology, J.M. Vargas School of Medicine, San José, Caracas, Venezuela.
authors.forename: F
authors.initials: F
authors.lastname: Rosa
authors.forename: J
authors.initials: J
authors.lastname: Vásquez
authors.forename: J
authors.initials: J
authors.lastname: Lupi
authors.forename: E
authors.initials: E
authors.lastname: Lezama
authors.forename: E
authors.initials: E
authors.lastname: Romero-Vecchione
mesh_terms: D000803:Angiotensin I / Q000378:metabolism; D057911:Angiotensin Receptor Antagonists; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D007276:Injections, Intraventricular; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D018340:Receptors, Adrenergic, alpha-1 / Q000187:drug effects / Q000378:metabolism; D011943:Receptors, Adrenergic, beta / Q000187:drug effects / Q000378:metabolism; D011945:Receptors, Angiotensin / Q000187:drug effects; D011985:Receptors, Serotonin / Q000187:drug effects; D012462:Saline Solution, Hypertonic; D013238:Stereotaxic Techniques; D014667:Vasopressins / Q000037:antagonists & inhibitors
chemical_list: D057911:Angiotensin Receptor Antagonists; D018340:Receptors, Adrenergic, alpha-1; D011943:Receptors, Adrenergic, beta; D011945:Receptors, Angiotensin; D011985:Receptors, Serotonin; D012462:Saline Solution, Hypertonic; D014667:Vasopressins; D000803:Angiotensin I