[Immunologic response of the body in thyroid gland involvement due to incorporation of varying doses of 131I].
The body's immunological responses were examined in thyroid damage caused by the incorporation of varying 131I doses. The in-take of 131I in doses of 37, 74, and 148 KBc/g body weight caused reductions in the murine blood concentrations of thyroxin following 30, 60, and 180 days. The blood levels of triiodothyronine decreased 180 days after administration of 131I in a dose of 74 KBc/g body weight and 30, 60, and 180 days after incorporation of the radioisotope in a dose of 148 KBk/g body weight. Decreased concentrations of the both hormones were followed by the suppression of a humoral immune response to sheep red blood cells, diminished cell-mediated immunity in the mixed culture of lymphocytes. The inhibition of immune responses was correlated with the changes in the level of triiodothyronine.
Gurova
N V
NV
Shchebnikova
N E
NE
Isaeva
S A
SA
Solov'ev
A S
AS
D000818:Animals; D000917:Antibody Formation; D007457:Iodine Radioisotopes / Q000633:toxicity; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D011833:Radiation Injuries, Experimental / Q000276:immunology*; D013959:Thyroid Diseases / Q000209:etiology / Q000276:immunology*
D007457:Iodine Radioisotopes
Immunologicheskie reaktsii organizma pri porazhenii shchitovidnoĭ zhelezy, vyzvannom inkorporirovaniem razlichnykh doz 131I.