title: [Mechanisms of the regulation of adrenergic beta-receptors].
abstract: Adrenaline and noradrenaline exert their effects via specific adrenergic receptors. Of the nine known subtypes of these receptors, the beta 1-subtype mediates an increase in cardiac contractility, while the beta 2-subtype is responsible for vasodilatation. These receptors are not just simple signal transducers but components of a complex and highly regulated signalling machinery. A loss of sensitivity of this machinery may be induced by exogenous as well as endogenous stimuli (= desensitisation). Desensitisation of cardiac beta-adrenergic receptors may contribute to contractile dysfunction in chronic heart failure.
authors.affiliation: Institut für Pharmakologie und Toxikologie, Würzburg.
authors.forename: M J
authors.initials: MJ
authors.lastname: Lohse
mesh_terms: D000818:Animals; D004837:Epinephrine / Q000502:physiology; D019204:GTP-Binding Proteins / Q000502:physiology; D006333:Heart Failure / Q000503:physiopathology*; D006801:Humans; D009200:Myocardial Contraction / Q000502:physiology; D009638:Norepinephrine / Q000502:physiology; D018342:Receptors, Adrenergic, beta-1 / Q000502:physiology*; D018343:Receptors, Adrenergic, beta-2 / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology; D014664:Vasodilation / Q000502:physiology
chemical_list: D018342:Receptors, Adrenergic, beta-1; D018343:Receptors, Adrenergic, beta-2; D019204:GTP-Binding Proteins; D009638:Norepinephrine; D004837:Epinephrine
vernacular_title: Mechanismen der Regulation beta-adrenerger Rezeptoren.