Evidence of osteolathyrism among patients suffering from neurolathyrism in Bangladesh.
In a study of 500 patients suffering from neurolathyrism in Bangladesh it was found that 60 (all male) complained of bone pain and showed skeletal deformities suggestive of osteolathyrism. On X-ray examination a failure of fusion in both vertebral and iliac epiphyses was found in two patients. At the age of these patients (30 and 37 years) such failure was considered a clear evidence of osteolathyrism. All 60 patients were accustomed to eating the green parts of Lathyrus sativus, which contain 2-cyanoethyl-isoxazolin-5-one, a compound that chemically and metabolically can produce the osteolathyrogen beta-aminopropionitrile (BAPN), as well as foods made from the seeds of the same plant which contain the neurotoxin 3-N-oxalyl-2,3-diaminopropanoic acid (beta-ODAP).
Haque
A
A
Institute for Post Graduate Medical Research, Shahbagh, Dhaka, Bangladesh.
Hossain
M
M
Lambein
F
F
Bell
E A
EA
D000328:Adult; D000629:Aminopropionitrile / Q000009:adverse effects; D001459:Bangladesh / Q000453:epidemiology; D001847:Bone Diseases / Q000139:chemically induced / Q000000981:diagnostic imaging* / Q000453:epidemiology; D006615:Hip / Q000000981:diagnostic imaging; D006801:Humans; D007842:Lathyrism / Q000139:chemically induced / Q000000981:diagnostic imaging* / Q000453:epidemiology; D008297:Male; D009422:Nervous System Diseases / Q000453:epidemiology*; D009498:Neurotoxins / Q000009:adverse effects; D011859:Radiography; D013131:Spine / Q000000981:diagnostic imaging
D009498:Neurotoxins; D000629:Aminopropionitrile