title: Nonbinomial distribution of relative neurite outgrowth in PC-12 cells.
abstract: Previously we reported the results of a series of experimental tests using PC-12 cells to examine the biological effect of prescribed combinations of both nerve growth factor and magnetic fields. Because our assay of the PC-12 cells is based on binary classification of the cells following treatment, our data might be expected to have a binomial distribution. However, our data consistently show a smaller variability than that predicted by the binomial distribution model. In this paper, we examine some possible reasons for this reduction in variability in our results.
authors.affiliation: U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711-2055, USA.
authors.forename: C F
authors.initials: CF
authors.lastname: Blackman
authors.forename: D E
authors.initials: DE
authors.lastname: House
authors.forename: J P
authors.initials: JP
authors.lastname: Blanchard
mesh_terms: D000465:Algorithms; D000818:Animals; D016010:Binomial Distribution; D002452:Cell Count; D003470:Culture Media; D003627:Data Interpretation, Statistical; D008280:Magnetics / Q000145:classification; D009414:Nerve Growth Factors / Q000494:pharmacology*; D016501:Neurites / Q000187:drug effects / Q000473:pathology*; D016716:PC12 Cells / Q000473:pathology*; D011336:Probability; D051381:Rats
chemical_list: D003470:Culture Media; D009414:Nerve Growth Factors