Chromosome analyses in a rhabdoid tumor of the brain.
A malignant rhabdoid tumor of the brain from a 19-month-old child was studied. Two related clones, 46,XX,-8,+der(8)t(8;22)(p11;q?12)x2,-22,del(22)(q12q?13) and 46,XX-8,+der(8)t(8;22) (p11;q?12) x2,-22,r(22) were found after chromosome analyses of primary and recurrent tumor, and multiple nude mouse passages of the tumor. Breakpoints were studied using FISH.
Klopfenstein
K
K
Department of Hematology/Oncology, Children's Hospital Medical Center, Cincinnati, Ohio 45229, USA.
Soukup
S
S
Blough
R
R
Mazewski
C
C
Ballard
E
E
Gotwals
B
B
Lampkin
B
B
D000818:Animals; D001932:Brain Neoplasms / Q000235:genetics*; D002872:Chromosome Deletion; D002892:Chromosomes, Human, Pair 22; D002898:Chromosomes, Human, Pair 8; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007223:Infant; D007621:Karyotyping; D051379:Mice; D008819:Mice, Nude; D018335:Rhabdoid Tumor / Q000235:genetics*; D014178:Translocation, Genetic