Dietary sucrose and starch affect dysplastic characteristics in carcinogen-induced aberrant crypt foci in rat colon.
To study whether dietary carbohydrates affect dysplasia in aberrant crypt foci (ACF), rats treated with 1,2-dimethilhydrazine (DMH) were fed for three months with diets containing 46% sucrose or corn starch. The number of ACF/colon in the two dietary groups was similar (P = 0.58), but ACF were smaller in the starch than in sucrose group (P < 0.05). ACF in the starch group also showed less severe goblet cell dysplasia, more sulphomucins and less sialomucins than in the sucrose group (P < 0.05), indicating that corn starch protects against colon carcinogenesis while sucrose in the diet is detrimental, promoting the dysplasia of preneoplastic lesions like ACF.
Caderni
G
G
Department of Pharmacology, University of Florence, Italy.
Lancioni
L
L
Luceri
C
C
Giannini
A
A
Lodovici
M
M
Biggeri
A
A
Dolara
P
P
D019813:1,2-Dimethylhydrazine; D000818:Animals; D002273:Carcinogens; D003110:Colonic Neoplasms / Q000517:prevention & control*; D019422:Dietary Sucrose / Q000627:therapeutic use*; D004127:Dimethylhydrazines; D005260:Female; D007413:Intestinal Mucosa / Q000187:drug effects / Q000473:pathology; D009077:Mucins / Q000096:biosynthesis / Q000737:chemistry; D011230:Precancerous Conditions / Q000139:chemically induced / Q000473:pathology* / Q000517:prevention & control; D051381:Rats; D017207:Rats, Sprague-Dawley; D013213:Starch / Q000627:therapeutic use*
D002273:Carcinogens; D019422:Dietary Sucrose; D004127:Dimethylhydrazines; D009077:Mucins; D013213:Starch; D019813:1,2-Dimethylhydrazine