Metastatic lobular carcinoma of the breast diagnosed in cervicovaginal samples. A case report.
BACKGROUND
Malignant tumors with extragenital origins are rare in cervicovaginal samples.


METHODS
A case of metastatic lobular carcinoma of the breast was diagnosed in a cervicovaginal smear. Histologic correlation was performed. Marker studies for carcinoembryonic antigen, human milk fat globule membrane, epidermal growth factor receptor, epithelial membrane antigen and cytokeratin were positive.


CONCLUSIONS
Recognition of extrauterine cancer in the cervicovaginal smear has important diagnostic, prognostic, and therapeutic implications.
Mallow
D W
DW
Department of Pathology, Duke University Medical Center, Durham, North Carolina 27710, USA.
Humphrey
P A
PA
Soper
J T
JT
Johnston
W W
WW
D000230:Adenocarcinoma / Q000737:chemistry / Q000556:secondary / Q000601:surgery; D000328:Adult; D014408:Biomarkers, Tumor; D001943:Breast Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D002272:Carcinoembryonic Antigen / Q000032:analysis; D018275:Carcinoma, Lobular / Q000737:chemistry / Q000556:secondary* / Q000601:surgery; D016889:Endometrial Neoplasms / Q000737:chemistry / Q000556:secondary* / Q000601:surgery; D066246:ErbB Receptors / Q000032:analysis; D005260:Female; D006801:Humans; D007044:Hysterectomy; D007633:Keratins / Q000032:analysis; D008408:Mastectomy; D008562:Membrane Glycoproteins / Q000032:analysis; D008894:Milk Proteins / Q000032:analysis; D018396:Mucin-1 / Q000032:analysis; D002583:Uterine Cervical Neoplasms / Q000737:chemistry / Q000556:secondary* / Q000601:surgery; D014626:Vaginal Smears
D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen; D008562:Membrane Glycoproteins; D008894:Milk Proteins; D018396:Mucin-1; D007633:Keratins; D066246:ErbB Receptors