title: Correlation between umbilical artery and vein levels of interleukin-6 and soluble intracellular adhesion molecule-1.
abstract: This study was designed to determine whether umbilical artery levels of both interleukin-6 (IL-6) and soluble intracellular adhesion molecule-1 (sICAM-1) correlate with levels in the umbilical vein. Paired umbilical artery-vein specimens were assayed for IL-6 and sICAM-1. The paired-sign test was used to compare umbilical artery vein levels of IL-6 and sICAM-1. Spearman rank correlation was used to determine relationships between paired umbilical artery-vein levels for a variety of clinical subgroups. For 23 paired samples overall, umbilical artery levels were greater than corresponding vein levels for both IL-6 (P = .039) and sICAM-1 (P = .035). Artery-vein correlations were significant for IL-6 (rho = 0.845, P = .001) and sICAM-1 (rho = 0.806, P = .0002). Correlations were not influenced by prematurity, route of delivery, labor, or neonatal sepsis. In conclusion, umbilical artery levels of IL-6 and sICAM-1 correlate significantly with umbilical vein levels.
authors.affiliation: Department of Obstetrics, Gynecology and Reproductive Sciences, University of Medicine and Dentistry of New Jersey, New Brunswick, 08903-0591, USA.
authors.forename: J C
authors.initials: JC
authors.lastname: Smulian
authors.forename: W A
authors.initials: WA
authors.lastname: Campbell
authors.forename: A M
authors.initials: AM
authors.lastname: Vintzileos
authors.forename: J F
authors.initials: JF
authors.lastname: Rodis
mesh_terms: D000293:Adolescent; D000328:Adult; D002585:Cesarean Section; D005260:Female; D005317:Fetal Growth Retardation / Q000097:blood; D005322:Premature Rupture of Fetal Membranes / Q000097:blood; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood*; D007752:Obstetric Labor, Premature / Q000097:blood*; D011225:Pre-Eclampsia / Q000097:blood; D011247:Pregnancy; D014469:Umbilical Arteries; D014471:Umbilical Veins
chemical_list: D015850:Interleukin-6; D018799:Intercellular Adhesion Molecule-1