Isotretinoin-induced vasculitis imitating polyarteritis nodosa, with perinuclear antineutrophil cytoplasmic antibody in titers correlated with clinical symptoms.
The adverse effects of retinoids on bones and joints are being increasingly documented. A case is reported in which isotretinoin was considered responsible for polyarteritis-like vasculitis. Perinuclear antineutrophil cytoplasmic antibodies were present in titers that correlated with clinical and laboratory test abnormalities.
Chochrad
D
D
Internal Medicine Department, Tournai Medical and Surgical Institute, Belgium.
Langhendries
J P
JP
Stolear
J C
JC
Godin
J
J
D000152:Acne Vulgaris / Q000188:drug therapy; D000293:Adolescent; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000032:analysis*; D003937:Diagnosis, Differential; D006801:Humans; D015474:Isotretinoin / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D010488:Polyarteritis Nodosa / Q000175:diagnosis*; D014657:Vasculitis / Q000139:chemically induced* / Q000175:diagnosis* / Q000276:immunology
D019268:Antibodies, Antineutrophil Cytoplasmic; D015474:Isotretinoin