Fulminant course of a microinvasive vulvar carcinoma in an immunosuppressed woman.
Iatrogenic immune suppression following renal transplantation is frequently associated with certain neoplasms, including vulvar carcinoma. We describe a patient with a vulvar carcinoma less than 1 mm depth of invasion and less than 3 mm superficial spread 12 years after renal transplantation. A simple vulvectomy was performed but 4 months later disease recurred in the inguinal nodes. The patient died 20 months later with progressive disease in the retroperitoneum and liver metastases.
Volgger
B
B
Department of Obstetrics and Gynecology, University Hospital Innsbruck, Austria.
Marth
C
C
Zeimet
A
A
Müller-Holzner
E
E
Ruth
N
N
Dapunt
O
O
D000328:Adult; D001379:Azathioprine / Q000009:adverse effects; D002273:Carcinogens / Q000009:adverse effects; D002278:Carcinoma in Situ / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D002294:Carcinoma, Squamous Cell / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D003218:Condylomata Acuminata / Q000473:pathology; D018450:Disease Progression; D005260:Female; D006801:Humans; D007165:Immunosuppression Therapy; D007166:Immunosuppressive Agents / Q000009:adverse effects; D016030:Kidney Transplantation / Q000009:adverse effects / Q000276:immunology; D008113:Liver Neoplasms / Q000556:secondary; D008207:Lymphatic Metastasis; D009361:Neoplasm Invasiveness; D009378:Neoplasms, Multiple Primary / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D011241:Prednisone / Q000009:adverse effects; D012307:Risk Factors; D014844:Vulva / Q000473:pathology / Q000601:surgery; D014845:Vulvar Diseases / Q000473:pathology; D014846:Vulvar Neoplasms / Q000209:etiology* / Q000473:pathology / Q000601:surgery
D002273:Carcinogens; D007166:Immunosuppressive Agents; D001379:Azathioprine; D011241:Prednisone