Gabapentin, ineffective in normal rats, markedly reduces C-fibre evoked responses after inflammation.
Gabapentin (Neurontin) is a novel anticonvulsant with an as yet unknown mechanism of action. This electrophysiological study investigated the potential antinociceptive actions of systemically administered gabapentin in normal animals and after inflammation induced by the injection of carrageenan. Gabapentin facilitated the noxious evoked responses of dorsal horn neurones recorded in normal animals. In complete contrast, gabapentin strongly and dose-dependently inhibited the C-fibre evoked response and post-discharge, but not the A beta-fibre evoked response, of neurones recorded in animals 3 h after the injection of carrageenan. This unique and selective profile of gabapentin may provide a novel treatment for clinical inflammatory pain states.
Stanfa
L C
LC
Department of Pharmacology, University College London, UK.
Singh
L
L
Williams
R G
RG
Dickenson
A H
AH
D000085:Acetates / Q000494:pharmacology*; D000344:Afferent Pathways / Q000187:drug effects / Q000502:physiology / Q000503:physiopathology; D000588:Amines; D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D002351:Carrageenan; D003509:Cyclohexanecarboxylic Acids; D004558:Electric Stimulation; D005071:Evoked Potentials / Q000187:drug effects*; D000077206:Gabapentin; D007249:Inflammation / Q000139:chemically induced / Q000503:physiopathology*; D008297:Male; D009412:Nerve Fibers / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012016:Reference Values; D013116:Spinal Cord / Q000187:drug effects / Q000502:physiology* / Q000503:physiopathology; D005680:gamma-Aminobutyric Acid
D000085:Acetates; D000588:Amines; D000700:Analgesics; D003509:Cyclohexanecarboxylic Acids; D005680:gamma-Aminobutyric Acid; D000077206:Gabapentin; D002351:Carrageenan