title: Design of highly potent noncovalent thrombin inhibitors that utilize a novel lipophilic binding pocket in the thrombin active site.
authors.affiliation: Department of Medicinal Chemistry, Merck Research Laboratories, West Point, Pennsylvania 19486, USA.
authors.forename: T J
authors.initials: TJ
authors.lastname: Tucker
authors.forename: W C
authors.initials: WC
authors.lastname: Lumma
authors.forename: A M
authors.initials: AM
authors.lastname: Mulichak
authors.forename: Z
authors.initials: Z
authors.lastname: Chen
authors.forename: A M
authors.initials: AM
authors.lastname: Naylor-Olsen
authors.forename: S D
authors.initials: SD
authors.lastname: Lewis
authors.forename: R
authors.initials: R
authors.lastname: Lucas
authors.forename: R M
authors.initials: RM
authors.lastname: Freidinger
authors.forename: L C
authors.initials: LC
authors.lastname: Kuo
mesh_terms: D001665:Binding Sites; D018360:Crystallography, X-Ray; D003514:Cyclohexylamines / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D004151:Dipeptides / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D015195:Drug Design; D005343:Fibrinolytic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D006860:Hydrogen Bonding; D015394:Molecular Structure; D011485:Protein Binding; D013917:Thrombin / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000378:metabolism
chemical_list: D003514:Cyclohexylamines; D004151:Dipeptides; D005343:Fibrinolytic Agents; D013917:Thrombin