title: Acute otitis media in pediatrics: are there rational issues for empiric therapy?
abstract: BACKGROUND
  Acute otitis media in children is a significant clinical problem that requires a rational approach to treatment. The condition is extremely common and has important economic implications. At present there is considerable controversy over the most appropriate strategy and over the use and choice of antibiotics.
  
  
  OBJECTIVE
  To analyze the various factors that influence therapeutic decisions and consider how these may assist in the formulation of a rational approach to therapy.
  
  
  CONCLUSIONS
  Otitis media has a multifactorial etiology but it is extremely difficult to differentiate between bacterial and viral causes on clinical grounds. Culture of the middle ear fluid is rarely practicable; however, nasal swabs are relatively noninvasive and can provide useful microbiologic information, especially in excluding a bacterial cause. Published information provides little guidance on the most appropriate therapy; a rational approach to treatment is based on many considerations including the local epidemiology. The minimum criteria for the empiric choice of an antibiotic for acute otitis media are that it should be rapidly bactericidal and reach adequate concentrations in the middle ear fluid. In areas where beta-lactamase-producing strains are prevalent, a beta-lactamase-stable antibiotic should be chosen; good absorption from the gastrointestinal tract and high and consistent penetration into the middle ear are important characteristics. Compliance-enhancing factors such as fewer doses per day and good palatability are also important.
authors.affiliation: Department of Paediatrics, University of Milan, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Boccazzi
authors.forename: P
authors.initials: P
authors.lastname: Careddu
mesh_terms: D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000175:diagnosis / Q000188:drug therapy; D002648:Child; D002675:Child, Preschool; D004358:Drug Therapy / Q000191:economics; D004432:Ear, Middle / Q000378:metabolism; D019348:Empiricism; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D010033:Otitis Media / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D010349:Patient Compliance; D010818:Practice Patterns, Physicians'; D014777:Virus Diseases / Q000175:diagnosis / Q000188:drug therapy; D001618:beta-Lactamases / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D001618:beta-Lactamases