title: Dosimetry of 60Co and 192Ir gamma-irradiated agarose gels by proton relaxation time measurement and NMR imaging, in a 0-100 Gy dose range.
abstract: Localized irradiation of the skin and subcutaneous tissues with large single doses of gamma rays can induce immediate effects characterized by erythema, desquamation, and necrosis. Correlations between the evolution of the lesions and dosimetry studies have to be established by biophysical methods. NMR studies of the effects of an irradiated Fricke solution might be a means of controlling the delivered irradiation doses. After exposition to ionizing radiations, ferrous ions are transformed into ferric ions. Both are paramagnetic ions, and proton spin-lattice relaxation is accelerated depending on the oxidation reaction. In this study, solution of ammonium ferrous sulfate in an acid environment was incorporated into a gelling substance made with agarose, so that T1 weighted image contrast could be used to detect ferric ion formation. Experiments with 192Ir and 60Co gamma rays with doses in the 0 to 100 Gy range were conducted with Fe2+ concentrations of 0.5, 1, 1.5, and 2 mM in a gelling substance containing 4% agarose. A relationship was established between the amount of Fe3+ created and the spin-lattice proton relaxation rate, which led to a straightforward dose-effect relation. The use of such high doses allowed us to reproduce realistic conditions of accidental overexposure. A linear relationship was obtained between the doses absorbed and the NMR parameters measured (T1 and relative image intensity).
authors.affiliation: Laboratoire de Résonance Magnétique Nucleaire-CNRS D2057, UniversitéClaude Bernard Lyon I, Villeurbanne, France.
authors.forename: A
authors.initials: A
authors.lastname: Chalansonnet
authors.forename: J L
authors.initials: JL
authors.lastname: Bonnat
authors.forename: Y
authors.initials: Y
authors.lastname: Tricaud
authors.forename: J L
authors.initials: JL
authors.lastname: Lefaix
authors.forename: A
authors.initials: A
authors.lastname: Briguet
mesh_terms: D003037:Cobalt Radioisotopes; D005720:Gamma Rays; D005782:Gels; D006801:Humans; D007496:Iridium Radioisotopes; D007501:Iron; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D019047:Phantoms, Imaging; D012685:Sepharose
chemical_list: D003037:Cobalt Radioisotopes; D005782:Gels; D007496:Iridium Radioisotopes; D012685:Sepharose; D007501:Iron