[The neurology and neuromorphology of hemorrhagic fever with renal syndrome].
Direct observation of 160 patients (In acute period of the disease and within 10-year followup), examination of 220 case records and neuroanatomic study of 37 cases were performed to study nervous system in patients suffered from hemorrhagic fever with renal syndrome. Severe, persistent and wide-spread neurological symptoms were described as well as mnemic-intellectual disturbances. The latter were defined as encephalopathic syndrome with pronounced neurological deficit. The anatomic study (light and electron microscopy) revealed dystrophic alterations of nervous tissue as well as viruses and virus-like substance in many regions of the brain. The authors suppose that direct viral action was the reason for tissue damages of nervous system. The viral penetration through hematoencephalic barrier was not excluded either.
Novikova
L B
LB
Shakirova
G R
GR
Borisova
N A
NA
D000208:Acute Disease; D000328:Adult; D001921:Brain / Q000473:pathology; D005260:Female; D006480:Hemorrhagic Fever with Renal Syndrome / Q000150:complications / Q000473:pathology* / Q000523:psychology; D006801:Humans; D007668:Kidney / Q000473:pathology; D008297:Male; D008569:Memory Disorders / Q000209:etiology / Q000473:pathology / Q000523:psychology; D008875:Middle Aged
Nevrologiia i neĭromorfologiia gemorragicheskoĭ likhoradki s pochechnym sindromom.