Southwestern Internal Medicine Conference: medical management of nephrolithiasis--a new, simplified approach for general practice.
Considerable progress has been made regarding pathophysiology, diagnosis, and medical prevention of recurrent renal stone formation. The medical approach is not applied widely because of the availability of extracorporeal shockwave lithotripsy and the complexity of medical diagnostic and treatment modalities. In this review, a simplified program for the medical management of stones is described. From analysis of stone risk factors in 24-hour urine specimens, uncomplicated calcium stone disease is separated from other stone diseases. The uncomplicated calcium stone disease, comprising the illness in the majority of patients with recurrent renal calculi, is characterized by normocalcemia, normouricemia, calcium stones, and the absence of urinary tract infection, bowel disease, or marked hyperoxaluria. Uncomplicated calcium stone disease is separated into a hypercalciuric group and a normocalciuric group. In the simplified treatment program, the hypercalciuric group would be offered thiazide plus potassium citrate, whereas the normocalciuric group would receive potassium citrate alone.
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University of Texas Southwestern Medical Center, Dallas 75235-8885, USA.
D001581:Benzothiadiazines; D002118:Calcium / Q000652:urine; D019343:Citric Acid / Q000652:urine; D004032:Diet / Q000009:adverse effects; D004232:Diuretics; D005194:Family Practice; D006073:Gout / Q000503:physiopathology; D006801:Humans; D007669:Kidney Calculi / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology; D019357:Potassium Citrate / Q000627:therapeutic use; D049993:Sodium Chloride Symporter Inhibitors / Q000627:therapeutic use
D001581:Benzothiadiazines; D004232:Diuretics; D049993:Sodium Chloride Symporter Inhibitors; D019343:Citric Acid; D019357:Potassium Citrate; D002118:Calcium