Review of the fetal radiation doses received from 59Fe kinetic studies at Vanderbilt University in the 1940's.
Fetal radiation dose estimates were calculated for women who received oral administrations of 59Fe at Vanderbilt University in the 1940's. A similar dosimetry analysis was performed by Dyer and Brill in 1972; the availability of recently developed physical models of the pregnant female at different stages of gestation and of a new kinetic model for iron metabolism afforded an opportunity to re-evaluate these doses. Radiation dose estimates for the fetus (and fetal liver in three cases) were calculated for a number of oral and intravenous studies using these new models and the available data about the original experiments. The total fetal doses do not appear to have exceeded a few hundred microgray (a few tens of millirad) for the majority of the study subjects. Considerable uncertainty exists, however, in the amount of activity administered to these subjects.
Stabin
M G
MG
Oak Ridge Institute for Science and Education, TN 37831-0117, USA.
Stubbs
J B
JB
Russell
J R
JR
D000284:Administration, Oral; D005314:Embryonic and Fetal Development; D005260:Female; D005865:Gestational Age; D006801:Humans; D007504:Iron Radioisotopes / Q000008:administration & dosage / Q000493:pharmacokinetics*; D007700:Kinetics; D008099:Liver / Q000196:embryology / Q000378:metabolism; D008954:Models, Biological; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D013714:Tennessee; D014018:Tissue Distribution; D014495:Universities
D007504:Iron Radioisotopes