Effects of ondansetron on short-term memory retrieval in mice.
Behavioral studies have shown cognitive improvements in various animal models of learning and memory using 5-HT3 receptor antagonists. The present study investigated the cognitive role of ondansetron, a selective 5-HT3 antagonist, in naive and scopolamine-treated mice. Ondansetron attenuated the performance deficits induced by scopolamine (0.3 mg/kg) with both doses employed, although 1.0 mg/kg ondansetron was more effective in ameliorating the deficits as compared to 0.1 mg/kg. However, none of the ondansetron doses (0.01, 0.1 and 1 mg/kg) influenced the performance of naive mice in the passive avoidance step-down paradigm. These results suggest that the 5-HT receptor system, particularly the 5-HT3 receptor, may play a modulating role in learning and memory phenomena in animals.
Roychoudhury
M
M
Pharmacology Division, Panjab University, Chandigarh, India.
Kulkarni
S K
SK
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D005260:Female; D008297:Male; D008570:Memory, Short-Term / Q000187:drug effects*; D051379:Mice; D008807:Mice, Inbred BALB C; D017294:Ondansetron / Q000494:pharmacology*
D017294:Ondansetron