title: [Ifosfamide chemotherapy ineffective for advanced pancreatic carcinoma].
abstract: Ifosfamide chemotherapy was studied in 20 patients with advanced pancreatic carcinoma. It was administered at a dose of 1.2-1.5 g/body/day for 5 consecutive days every 3-4 weeks, and the patients treated over 2 courses were registered in our trial. Eleven patients had not received prior chemotherapy. Results achieved were as follows: PR in one patient, NC in 9 patients, and PD in 10 patients. The response rate was 5% and the median survival time was 17 weeks. Toxic effects included anorexia (80%), nausea and vomiting (65%), alopecia (20%), mental disturbance (20%), granulocytopenia (20%), thrombocytopenia (5%), and no renalurological disturbance. We concluded that ifosfamide was not effective for chemotherapy of advanced pancreatic carcinoma.
authors.affiliation: Dept. of Gastroenterology, Saitama Cancer Center Hospital.
authors.forename: T
authors.initials: T
authors.lastname: Fujiki
authors.forename: K
authors.initials: K
authors.lastname: Futatsuki
authors.forename: S
authors.initials: S
authors.lastname: Akazawa
authors.forename: K
authors.initials: K
authors.lastname: Yamamoto
authors.forename: Y
authors.initials: Y
authors.lastname: Kanda
authors.forename: A
authors.initials: A
authors.lastname: Yamato
authors.forename: K
authors.initials: K
authors.lastname: Terashi
authors.forename: Y
authors.initials: Y
authors.lastname: Suda
mesh_terms: D000328:Adult; D000368:Aged; D000855:Anorexia / Q000139:chemically induced; D018906:Antineoplastic Agents, Alkylating / Q000009:adverse effects / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007069:Ifosfamide / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009325:Nausea / Q000139:chemically induced; D010190:Pancreatic Neoplasms / Q000188:drug therapy* / Q000401:mortality; D016019:Survival Analysis; D014839:Vomiting / Q000139:chemically induced
chemical_list: D018906:Antineoplastic Agents, Alkylating; D007069:Ifosfamide