Presynaptic inhibition by serotonin: a possible mechanism for switching motor output of the hypoglossal nucleus.
We examined the influence of serotonin (5-HT), an important state-dependent neuromodulator, on synaptic transmission to hypoglossal motoneurons (HMs). Our data demonstrate that 5-HT acts presynaptically to inhibit excitatory (glutamatergic) synaptic currents recorded in HMs. We discuss this result in relation to the role of 5-HT in state-dependent modulation of respiration-related activity in HMs.
Singer
J H
JH
Department of Physiology and Biophysics, University of Washington School of Medicine, Seattle 98195-7290, USA.
Berger
A J
AJ
D046508:Culture Techniques; D018698:Glutamic Acid / Q000378:metabolism; D006801:Humans; D007002:Hypoglossal Nerve / Q000187:drug effects*; D009046:Motor Neurons / Q000187:drug effects*; D017661:Receptors, Presynaptic / Q000187:drug effects*; D012701:Serotonin / Q000494:pharmacology*; D009435:Synaptic Transmission / Q000187:drug effects*
D017661:Receptors, Presynaptic; D012701:Serotonin; D018698:Glutamic Acid