[The characteristics of the immune response in acute viral hepatitis B].
The clinical and pathogenetic importance of a number of features characterizing cell-mediated immunity and nonspecific protective factors in acute virus hepatitis B. 124 patients with hepatitis B virus (HBV) infection were placed under observation. Of these, 115 patients had acute virus hepatitis B, 6 patients had acute virus hepatitis of mixed etiology (B + delta) and 3 patients had chronic virus hepatitis B. The study included, besides the detection of virus hepatitis markers and the biochemical analysis of blood, the determination of subpopulations of peripheral blood lymphocytes (CD3, CD4, CD8, CD57), the functional activity of natural killers, characteristics of the interferon status, serum neopterin and beta 2-microglobulin in blood serum. Considerable changes in cell-mediated immunity and the interferon system were found to occur and the optimum immune response in acute virus hepatitis B was characterized.
Cheshik
S G
SG
Golban
T D
TD
Kuznetsov
V P
VP
D000208:Acute Disease; D000328:Adult; D000917:Antibody Formation; D001708:Biopterins / Q000031:analogs & derivatives / Q000097:blood; D002908:Chronic Disease; D005260:Female; D006509:Hepatitis B / Q000209:etiology / Q000276:immunology*; D003699:Hepatitis D / Q000209:etiology / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular; D007372:Interferons / Q000097:blood; D008297:Male; D019798:Neopterin; D016176:T-Lymphocyte Subsets / Q000276:immunology; D001613:beta 2-Microglobulin / Q000032:analysis
D001613:beta 2-Microglobulin; D001708:Biopterins; D019798:Neopterin; D007372:Interferons
Nekotorye osobennosti immunnogo otveta pri ostrom virusnom gepatite B.