Radiopharmacokinetic data for 99mTc-ABP--a new radiopharmaceutical for bone scanning: comparison with 99mTc-MDP.
Technetium-99m-labeled alendronate is a new radiopharmaceutical for bone scanning developed under strict quality control at the INNSZ. The purpose of this work was to compare the radiopharmacokinetic data and the dosimetry of 99mTc-ABP and 99mTc-MDP in 10 volunteers, after it was tested in laboratory animals. 99mTc-ABP has shorter mean residence time (MRT) and t 1/2 beta; is less protein bound; has a higher renal clearance; smaller Vdss, and similar bone uptake at 1 and 2 h. 99mTc-ABP gives less radiation exposure to the patient with a 740 MBq dose, and the quality of the bone scan is excellent. 99mTc-ABP is a better radiopharmaceutical than 99mTc-MDP for bone scanning.
Arteaga de Murphy
C
C
Instituto Nacional de Nutrición Salvador Zubirán, México City, México.
Meléndez-Alafort
L
L
Montoya-Molina
C E
CE
Sepúlveda-Méndez
J
J
D000328:Adult; D019386:Alendronate / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics; D000818:Animals; D019540:Area Under Curve; D001842:Bone and Bones / Q000000981:diagnostic imaging*; D005260:Female; D006207:Half-Life; D006801:Humans; D008297:Male; D051379:Mice; D015609:Organotechnetium Compounds / Q000097:blood / Q000493:pharmacokinetics*; D011817:Rabbits; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000097:blood / Q000493:pharmacokinetics*; D051381:Rats; D017208:Rats, Wistar; D013669:Technetium Tc 99m Medronate / Q000097:blood / Q000493:pharmacokinetics*; D014018:Tissue Distribution
D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; C105924:technetium Tc 99m alendronate; D019386:Alendronate; D013669:Technetium Tc 99m Medronate