title: [Acute cocaine intoxication with fatal outcome].
abstract: The clinical course and some toxicologic-analytical aspects of an acute intoxication with cocaine are presented. Diagnosis was made by the induced toxicologic emergency investigation since neither symptoms nor clinical test results or anamnestic data showed relevant diagnostic information. Based on the results of the analytic investigation, we concluded it was a suicide based on long-term abuse of cocaine. Because of the unusually high concentrations of cocaine und cocaine metabolites in the body of liquids and tissues, it seemed probable that the patient was intoxicated with a lethal dose of at least 1 g cocaine. This case report underlines the importance of clinical and toxicological investigations in the diagnostic procedure of unclear comata and the importance of forensic toxicological analysis in clarifying anamnestic questions.
authors.affiliation: Klinik und Poliklinik für Anaesthesiologie und Intensivtherapie, Medizinischen Fakultät, Universität Rostock.
authors.forename: I
authors.initials: I
authors.lastname: Rudolph
authors.forename: B
authors.initials: B
authors.lastname: Tiefenbach
authors.forename: D
authors.initials: D
authors.lastname: Tiess
authors.forename: R
authors.initials: R
authors.lastname: Wegener
authors.forename: R
authors.initials: R
authors.lastname: Kloock
authors.forename: M
authors.initials: M
authors.lastname: Kobow
mesh_terms: D000328:Adult; D003042:Cocaine / Q000493:pharmacokinetics / Q000506:poisoning*; D062787:Drug Overdose / Q000097:blood*; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D009293:Opioid-Related Disorders / Q000097:blood*; D013405:Suicide; D014018:Tissue Distribution
chemical_list: D003042:Cocaine
vernacular_title: Akute Cocain-Intoxikation mit tödlichem Ausgang.