title: Evidence of osteolathyrism among patients suffering from neurolathyrism in Bangladesh.
abstract: In a study of 500 patients suffering from neurolathyrism in Bangladesh it was found that 60 (all male) complained of bone pain and showed skeletal deformities suggestive of osteolathyrism. On X-ray examination a failure of fusion in both vertebral and iliac epiphyses was found in two patients. At the age of these patients (30 and 37 years) such failure was considered a clear evidence of osteolathyrism. All 60 patients were accustomed to eating the green parts of Lathyrus sativus, which contain 2-cyanoethyl-isoxazolin-5-one, a compound that chemically and metabolically can produce the osteolathyrogen beta-aminopropionitrile (BAPN), as well as foods made from the seeds of the same plant which contain the neurotoxin 3-N-oxalyl-2,3-diaminopropanoic acid (beta-ODAP).
authors.affiliation: Institute for Post Graduate Medical Research, Shahbagh, Dhaka, Bangladesh.
authors.forename: A
authors.initials: A
authors.lastname: Haque
authors.forename: M
authors.initials: M
authors.lastname: Hossain
authors.forename: F
authors.initials: F
authors.lastname: Lambein
authors.forename: E A
authors.initials: EA
authors.lastname: Bell
mesh_terms: D000328:Adult; D000629:Aminopropionitrile / Q000009:adverse effects; D001459:Bangladesh / Q000453:epidemiology; D001847:Bone Diseases / Q000139:chemically induced / Q000000981:diagnostic imaging* / Q000453:epidemiology; D006615:Hip / Q000000981:diagnostic imaging; D006801:Humans; D007842:Lathyrism / Q000139:chemically induced / Q000000981:diagnostic imaging* / Q000453:epidemiology; D008297:Male; D009422:Nervous System Diseases / Q000453:epidemiology*; D009498:Neurotoxins / Q000009:adverse effects; D011859:Radiography; D013131:Spine / Q000000981:diagnostic imaging
chemical_list: D009498:Neurotoxins; D000629:Aminopropionitrile