Acetylsalicylate and salicylates in foods.
Acetylsalicylic acid is effective in the prevention of cardiovascular disease. It was suggested that fruits and vegetables provide unknown amounts of acetylsalicylic acid. We could not find any acetylsalicylic acid in 30 foods using HPLC with fluorescence detection (detection limits: 0.02 mg/kg for fresh, and 0.2 mg/kg for dried products). We showed that urinary excretion of salicylates is a valid indicator for intake, and found a median salicylate excretion of 10 micromol (1.4 mg) in 24 h urine of 17 volunteers eating a variety of diets. Our data suggest that the content of (acetyl)salicylic acid of diets may be too low to affect disease risk.
Janssen
P L
PL
Department of Human Nutrition, Agricultural University, Wageningen, The Netherlands. karin.janssen@et3.voed.wau.nl
Katan
M B
MB
van Staveren
W A
WA
Hollman
P C
PC
Venema
D P
DP
D001241:Aspirin / Q000032:analysis* / Q000494:pharmacology / Q000652:urine*; D002851:Chromatography, High Pressure Liquid; D018592:Cross-Over Studies; D005504:Food Analysis; D005638:Fruit / Q000737:chemistry; D006801:Humans; D019684:Magnoliopsida / Q000737:chemistry; D012459:Salicylates / Q000032:analysis* / Q000494:pharmacology / Q000652:urine*; D017365:Spices / Q000032:analysis; D014675:Vegetables / Q000737:chemistry
D012459:Salicylates; D001241:Aspirin