title: Factor-derived subsyndromes of schizophrenia and familial morbid risks.
abstract: Factor analysis was performed on OPCRIT checklist ratings from 66 patients with RDC schizophrenia. Eight substantive factors were found, characterised respectively by: positive formal thought disorder; first rank delusions; first rank hallucinations; inappropriate affect/bizarre behaviour; negative symptoms; grandiose/bizarre delusions; delusions of influence/persecution; and other hallucinations. A history of schizophrenia and other non-affective psychoses was ascertained in the probands' first-degree relatives using a family history approach. Illness in relatives was best predicted by probands' scores on subsyndromes derived from the inappropriate affect/bizarre behaviour and positive formal thought disorder factors.
authors.affiliation: Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff, UK.
authors.forename: A G
authors.initials: AG
authors.lastname: Cardno
authors.forename: P A
authors.initials: PA
authors.lastname: Holmans
authors.forename: I
authors.initials: I
authors.lastname: Harvey
authors.forename: M B
authors.initials: MB
authors.lastname: Williams
authors.forename: M J
authors.initials: MJ
authors.lastname: Owen
authors.forename: P
authors.initials: P
authors.lastname: McGuffin
mesh_terms: D000328:Adult; D016009:Chi-Square Distribution; D003430:Cross-Sectional Studies; D005163:Factor Analysis, Statistical; D005192:Family Health; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D012559:Schizophrenia / Q000145:classification* / Q000235:genetics / Q000503:physiopathology; D006113:United Kingdom