Sperm head abnormalities and dominant lethal effects of formaldehyde in albino rats.
The effects of formaldehyde exposure have been investigated in rats by two short-term in vivo mutagenicity tests (sperm head abnormality and dominant lethal mutation assays). Five daily interperitonial injections of formaldehyde resulted in a statistically significant increase in induction of sperm head abnormalities at 0.125 to 0.500 mg/kg. The frequency of dominant lethal mutations in female rats sired by males exposed to formaldehyde was significantly higher than the control group. There was also a reduction of fertile matings in females mated 1-7 days after treatment of males with formaldehyde. The genetic and environmental health implications of the results are discussed.
Odeigah
P G
PG
Department of Biological Sciences, University of Lagos, Akoka, Nigeria.
D000818:Animals; D005260:Female; D005557:Formaldehyde / Q000633:toxicity*; D005799:Genes, Dominant; D005804:Genes, Lethal; D008297:Male; D009153:Mutagens / Q000633:toxicity*; D018812:Paternal Exposure; D051381:Rats; D011919:Rats, Inbred Strains; D013077:Sperm Head / Q000187:drug effects* / Q000473:pathology; D013094:Spermatozoa / Q000002:abnormalities* / Q000187:drug effects
D009153:Mutagens; D005557:Formaldehyde