The human transcriptional adaptor genes TADA2L and GCN5L2 colocalize to chromosome 17q12-q21 and display a similar tissue expression pattern.
The chromosomal locations and the tissue expression patterns of the human transcriptional adaptors TADA2L and GCN5L2 have been determined. Northern blot analysis across a range of human tissues revealed that both the TADA2L and the GCN5L2 mRNAs are expressed to varying degrees in all tissue types. Furthermore, in most tissue types, the genes are expressed at relatively similar levels, suggesting coordinated regulation of TADA2L and GCN5L2 transcription. Chromosomal mapping by fluorescence in situ hybridization indicated that these genes reside near each other on chromosome 17; TADA2L mapped within bands 17q12-q21, while GCN5L2 mapped distally within band 17q21.
Carter
K C
KC
Department of Molecular Biology, Human Genome Sciences, 9410 Key West Avenue, Rockville, Maryland 20850-3331, USA.
Wang
L
L
Shell
B K
BK
Zamir
I
I
Berger
S L
SL
Moore
P A
PA
D048868:Adaptor Proteins, Signal Transducing; D018797:Cell Cycle Proteins; D002874:Chromosome Mapping; D002886:Chromosomes, Human, Pair 17; D004268:DNA-Binding Proteins; D005786:Gene Expression Regulation; D051548:Histone Acetyltransferases; D006801:Humans; D017403:In Situ Hybridization; D009928:Organ Specificity; D015534:Trans-Activators / Q000235:genetics*; D014157:Transcription Factors / Q000235:genetics*; D050880:p300-CBP Transcription Factors; D000099224:p300-CBP-Associated Factor
D048868:Adaptor Proteins, Signal Transducing; D018797:Cell Cycle Proteins; D004268:DNA-Binding Proteins; D051548:Histone Acetyltransferases; D015534:Trans-Activators; D014157:Transcription Factors; D050880:p300-CBP Transcription Factors; D000099224:p300-CBP-Associated Factor; C097695:TADA2A protein, human