Characterization of clofazimine metabolites in humans by HPLC-electrospray mass spectrometry.
Clofazimine (CAS 2030-63-9) is an important drug used in the treatment of leprosy. Its important metabolites are investigated by thin layer chromatography (TLC), HPLC (diode array) and HPLC-electrospray mass spectrometry. The resulting analytical data, extraction, isolation and characterization methods are presented. Their applicability is described for human urine analysis.
Krishna
D R
DR
Drug Metabolism Laboratory University College of Pharmaceutical Sciences, Kakatiya University, Warangal, India.
Mamidi
R N
RN
Hofmann
U
U
Prabhakar
C M
CM
D000328:Adult; D001711:Biotransformation; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D002991:Clofazimine / Q000493:pharmacokinetics* / Q000652:urine; D006801:Humans; D007917:Leprostatic Agents / Q000493:pharmacokinetics* / Q000652:urine; D008099:Liver / Q000201:enzymology; D008297:Male; D013058:Mass Spectrometry
D007917:Leprostatic Agents; D002991:Clofazimine