title: Active efflux of antimicrobial agents in wild-type strains of enterococci.
abstract: Enterococci are intrinsically resistant to numerous antimicrobial agents. We examined the energy-dependent efflux of radiolabeled drugs from four reference strains of Enterococcus faecalis and a strain of Enterococcus faecium and found that most strains pumped out norfloxacin and chloramphenicol. Efflux of tetracycline was detected only in certain strains.
authors.affiliation: Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA.
authors.forename: C
authors.initials: C
authors.lastname: Lynch
authors.forename: P
authors.initials: P
authors.lastname: Courvalin
authors.forename: H
authors.initials: H
authors.lastname: Nikaido
mesh_terms: D000900:Anti-Bacterial Agents / Q000378:metabolism* / Q000494:pharmacology; D002701:Chloramphenicol / Q000378:metabolism / Q000494:pharmacology; D013293:Enterococcus faecalis / Q000187:drug effects / Q000378:metabolism*; D016984:Enterococcus faecium / Q000187:drug effects / Q000378:metabolism*; D008826:Microbial Sensitivity Tests; D009643:Norfloxacin / Q000378:metabolism / Q000494:pharmacology; D013752:Tetracycline / Q000378:metabolism / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D002701:Chloramphenicol; D013752:Tetracycline; D009643:Norfloxacin