title: Yeast metallothionein gene expression in response to metals and oxidative stress.
abstract: Metals and oxygen are chemically linked in biological systems. Metals and oxygen play important roles in enzymatic reactions, metabolism, and signal transduction; however, metals and oxygen react to form highly toxic oxygen-derived free radical species. In this review we focus on the use of yeast cells, as unicellular eukaryotic model systems, to conduct studies aimed at understanding fundamental mechanisms for the sensation and protective responses to toxic metals and oxygen-derived radicals via the activation of yeast metallothionein gene expression.
authors.affiliation: Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor 48109-0606, USA.
authors.forename: X D
authors.initials: XD
authors.lastname: Liu
authors.forename: D J
authors.initials: DJ
authors.lastname: Thiele
mesh_terms: D000975:Antioxidants / Q000378:metabolism; D002175:Candida / Q000235:genetics / Q000378:metabolism; D002352:Carrier Proteins; D004268:DNA-Binding Proteins / Q000378:metabolism; D005656:Fungal Proteins / Q000378:metabolism / Q000494:pharmacology; D015966:Gene Expression Regulation, Fungal; D008668:Metallothionein / Q000235:genetics* / Q000378:metabolism; D008670:Metals / Q000494:pharmacology*; D018384:Oxidative Stress / Q000502:physiology*; D012441:Saccharomyces cerevisiae / Q000235:genetics* / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism; D015533:Transcriptional Activation / Q000235:genetics
chemical_list: D000975:Antioxidants; C500769:CUP1-1 protein, S cerevisiae; C060256:CUP2 protein, S cerevisiae; D002352:Carrier Proteins; D004268:DNA-Binding Proteins; D005656:Fungal Proteins; D008670:Metals; D029701:Saccharomyces cerevisiae Proteins; D014157:Transcription Factors; C007121:copper thionein; D008668:Metallothionein