title: Kinetic analysis of rubidium and thallium as deposited myocardial blood flow tracers in isolated rabbit heart.
abstract: Evaluation of myocardial perfusion with tracers such as thallium and rubidium is based on the assumption that tissue tracer content is proportional to flow. The purpose of this study was to evaluate the relationship between flow and tissue tracer content of 201Tl and 83Rb in the isolated perfused rabbit heart. 83Rb (86-day half-life), an isotope that is not used clinically, was used as a subsitute for 82Rb (76-s half-life) to improve the accuracy and precision of data acquisition. The multiple indicator-dilution technique was employed with two independent computational approaches. The first approach explicitly deconvolved 201Tl and 83Rb venous concentration curves by the intravascular reference tracer curve. The second approach used a conventional analysis. Both approaches showed that there was more early washout of 83Rb than 201Tl and that the heart retained 201Tl better than 83Rb within 2 min after isotope introduction. These data indicate that 201Tl is a better perfusion tracer than 83Rb in the isolated rabbit heart.
authors.affiliation: E.O. Lawrence Berkeley National Laboratory, Center for Functional Imaging, California 94720, USA.
authors.forename: R C
authors.initials: RC
authors.lastname: Marshall
authors.forename: S E
authors.initials: SE
authors.lastname: Taylor
authors.forename: P
authors.initials: P
authors.lastname: Powers-Risius
authors.forename: B W
authors.initials: BW
authors.lastname: Reutter
authors.forename: A
authors.initials: A
authors.lastname: Kuruc
authors.forename: P G
authors.initials: PG
authors.lastname: Coxson
authors.forename: R H
authors.initials: RH
authors.lastname: Huesman
authors.forename: T F
authors.initials: TF
authors.lastname: Budinger
mesh_terms: D000818:Animals; D003326:Coronary Circulation; D004912:Erythrocytes / Q000378:metabolism; D006321:Heart / Q000000981:diagnostic imaging*; D066298:In Vitro Techniques; D007700:Kinetics; D008955:Models, Cardiovascular; D009206:Myocardium / Q000378:metabolism*; D011817:Rabbits; D011877:Radionuclide Imaging; D012039:Regional Blood Flow; D012414:Rubidium Radioisotopes / Q000493:pharmacokinetics*; D013794:Thallium Radioisotopes / Q000493:pharmacokinetics*; D013997:Time Factors
chemical_list: D012414:Rubidium Radioisotopes; D013794:Thallium Radioisotopes