[The antimicrobial activity and cytotoxicity of anti-infective preparations in a human cell-culture model].
The complex evaluation of Polysept, a new antiseptic, by its antimicrobial activity with the determination of the minimal inhibiting concentration, its antiadhesive effect and its cytotoxic action with the determination of the minimal toxic dose is presented after preclinical trial, carried out on the culture of skin and lung fibroblasts of human embryo used as an experimental model. The presence of 50% human blood serum enhances the antimicrobial and antiadhesive effects and decreases the cytotoxic action of the antiseptic with respect to fibroblasts, which makes it a promising preparation not only for the treatment, but also for prophylaxis of wound infection.
Afinogenov
G E
GE
Eropkina
E M
EM
Bondarenko
V M
VM
Eropkin
M Iu
MIu
D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000633:toxicity; D000891:Anti-Infective Agents, Local / Q000494:pharmacology* / Q000633:toxicity; D002460:Cell Line; D002478:Cells, Cultured; D016895:Culture Media, Serum-Free; D004305:Dose-Response Relationship, Drug; D004622:Embryo, Mammalian; D004926:Escherichia coli / Q000187:drug effects; D005347:Fibroblasts / Q000187:drug effects; D006146:Guanidines / Q000494:pharmacology* / Q000633:toxicity; D006801:Humans; D008168:Lung; D008826:Microbial Sensitivity Tests / Q000379:methods; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D000644:Quaternary Ammonium Compounds / Q000494:pharmacology* / Q000633:toxicity; D012867:Skin; D013211:Staphylococcus aureus / Q000187:drug effects
D000900:Anti-Bacterial Agents; D000891:Anti-Infective Agents, Local; D016895:Culture Media, Serum-Free; D006146:Guanidines; D000644:Quaternary Ammonium Compounds; C060540:polyhexamethyleneguanidine; C031490:catamine AB
Issledovanie protivomikrobnoĭ aktivnosti i tsitotoksichnosti antiinfektsionnykh preparatov na modeli kul'tury kletok cheloveka.