Using genetic information to make surgical decisions: report of a case of a 13-year-old boy with colon cancer.
OBJECTIVE
We report the case of a boy aged 13 years who was diagnosed with a Dukes B obstructing cancer of the sigmoid colon. At the time of diagnosis, he underwent a Hartmann's procedure with end colostomy. Because of his unusually young age, he was referred to the Familial GI Cancer Registry at Mount Sinai Hospital for genetic assessment. A detailed pedigree revealed no significant history other than lung cancer in his maternal grandfather.


METHODS
We obtained his tumor specimen and performed molecular analysis of both normal colonic and tumor DNA. Specifically, we identified replication errors (RER) in the patient's tumor DNA when compared with normal colonic DNA. RER has been found in more than 90 percent of tumors from patients with Hereditary Nonpolyposis Colon Cancer (HNPCC) and is, thus, considered to be one of the hallmarks of this disease. Because HNPCC patients have a 40 percent risk of synchronous or metachronous tumors, the recommended surgery for HNPCC should be at least a subtotal colectomy with ileorectal anastomosis.


RESULTS
Based on molecular results, we were able to recommend that the patient have a subtotal colectomy performed instead of merely colostomy closure, to reduce his lifetime risk of developing further colon tumors and to make surveillance of the remaining rectum relatively easy. In this patient, we subsequently identified a germline mutation of the mismatch repair gene hMSH2 that is implicated in HNPCC. The possibility of HNPCC should be considered in adolescents who are diagnosed with colorectal cancer, so appropriate surgical decisions can be made.
Madlensky
L
L
Steve Atanas Stavro Familial GI Cancer Registry, Mount Sinai Hospital, Toronto, Ontario, Canada.
Bapat
B
B
Redston
M
M
Pearl
R
R
Gallinger
S
S
Cohen
Z
Z
D002288:Adenocarcinoma, Mucinous / Q000235:genetics* / Q000601:surgery*; D000293:Adolescent; D003082:Colectomy; D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000235:genetics* / Q000517:prevention & control; D003125:Colostomy; D004261:DNA Replication; D004273:DNA, Neoplasm / Q000235:genetics; D005817:Genetic Counseling; D006801:Humans; D008297:Male; D018895:Microsatellite Repeats; D010375:Pedigree; D012042:Registries; D012307:Risk Factors; D012811:Sigmoid Neoplasms / Q000235:genetics* / Q000601:surgery*
D004273:DNA, Neoplasm