[The cholinesterase reactivity of the Komandor squid Berryteuthis magister. Substrates and organophosphorus inhibitors].
With the substrate inhibition analysis it has been shown that the one enzyme is responsible for the choline-esterase activity of optic ganglia tissue of Comandor squid Berryteuthis magister from different regions of Bering and Japanese seas. The kinetic parameters of the choline-esterase hydrolysis with 8 choline esters have been determined. It demonstrates the wide spectrum of the substrate specificity of Comandor squid choline-esterase. The antienzyme efficiency for 18 organophosphorus inhibitors (among them 7 compounds containing acetylene group) has been investigated. Also the new information about choline-esterase "structure-action" connection for Comandor squid has been obtained. The quantitative differences in the substrate specificity and reactivity for organophosphorus inhibitors of choline-esterases of Comandor and Pacific squids have been obtained. It has not succeeded to find the intraspecific differences for Comandor squid species from various living zones using the investigated effects.
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D000818:Animals; D002800:Cholinesterase Inhibitors / Q000494:pharmacology*; D002802:Cholinesterases / Q000187:drug effects*; D049832:Decapodiformes / Q000187:drug effects / Q000201:enzymology*; D017952:Ganglia, Invertebrate / Q000187:drug effects / Q000201:enzymology; D017950:Ganglia, Sensory / Q000187:drug effects / Q000201:enzymology; D009943:Organophosphorus Compounds / Q000494:pharmacology*; D013045:Species Specificity; D013379:Substrate Specificity / Q000187:drug effects
D002800:Cholinesterase Inhibitors; D009943:Organophosphorus Compounds; D002802:Cholinesterases
Reaktsionnaia sposobnost' kholinésteraz komandorskogo kal'mara Berryteuthis magister. Substraty i fosfororganicheskie ingibitory.