[Gastroesophageal reflux and esophageal motility disorders in infants with vagal hyperreflectivity presenting severe syncope].
OBJECTIVE
The aim of the study was to evaluate the prevalence of gastroesophageal reflux and abnormalities of esophageal motility in a population of neonates referred for apparently life threatening event (ALTE) and presenting vagal hyperreflectivity.


METHODS
The study included 17 infants, who were examined after an ALTE. They were admitted at a mean age of 11.7 weeks (range 1-40 weeks). Vagal hyperreflectivity was confirmed in each infant by oculocardiac reflex. Before treatment, 24-hour intraesophageal pH-monitoring and esophageal manometry were performed.


RESULTS
pH-monitoring and esophageal manometry were both normal in only two patients. pH-monitoring showed pathological reflux (% of time with pH < 4 more than 4.8%) in 10/17 (59%) patients. Manometric studies showed esophageal dysmotility in 12/17 (71%) of patients. Hypertensive lower sphincter was noted in 11/17 (65%) infants. Patients with normal manometry were older than patients presenting with esophageal dysmotility (P < 0.05).


CONCLUSIONS
This study shows a high frequency of gastroesophageal reflux and dysmotility in infants with vagal hyperreflectivity. Hypertensive lower esophageal sphincter as well as vagal hyperreflectivity may correspond to dysmaturity of autonomous nervous system and facilitate the occurrence of ALTE.
Michaud
L
L
Service de pédiatrie, gastroentérologie pédiatrique et génétique médicale, CHU, hôpital Claude-Huriez, Lille, France.
Lamblin
M D
MD
Carpentier
C
C
Engles
M C
MC
Gottrand
F
F
Piotte
M
M
Guieu
J D
JD
Lequien
P
P
Turck
D
D
D015154:Esophageal Motility Disorders / Q000150:complications*; D004947:Esophagus / Q000503:physiopathology; D005260:Female; D005764:Gastroesophageal Reflux / Q000150:complications*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008365:Manometry; D011446:Prospective Studies; D012018:Reflex; D013575:Syncope / Q000150:complications*; D014630:Vagus Nerve / Q000503:physiopathology*
Reflux gastroesophagien et troubles de la motricité oesophagienne chez des nourrissons porteurs d'une hyper-réflectivité vagale ayant présenté un malaise grave.