The presence of antithyroid antibodies in euthyroid patients with unexplained infertility and tubal obstruction.
OBJECTIVE
The presence of antithyroid antibodies in euthyroid patients with unexplained infertility and tubal obstruction.


METHODS
The presence of antithyroid autoantibodies (microsomal and thyroglobulin) was measured in 40 patients with unexplained infertility, and 40 patients with tubal obstruction infertility, and compared to 40 healthy nulligravidae.


RESULTS
Eight patients (20%) in the unexplained infertility study group, seven (17.5%) in the tubal obstruction group and two (5%) in the healthy nulligravida group, were positive for antithyroid autoantibodies: five (12.5%) were positive for antimicrosomal antibodies, two (5%) were positive for antithyroglobulin antibodies, and one patient (2.5%) was positive for both. The tubal obstruction group comprised seven (17.5%) patients positive for antithyroid autoantibodies: four (10%) for antimicrosomal antibodies, two (5%) for antithyroglobulin antibodies, and one patient (2.5%) was positive for both. In the healthy nulligravidae group only two patients (5%) were positive for antithyroid antibodies: one for antimicrosomal and one for antithyroglobulin. No significant differences were found in the presence of antithyroid antibodies between patients with unexplained infertility and those with tubal obstruction infertility. Both groups differed significantly from the healthy controls with regard to the presence of antithyroid antibodies (P < 0.05).


CONCLUSIONS
Subclinical presence of antithyroid autoantibodies is characteristic of both unexplained and mechanical infertility, as opposed to healthy controls. Further investigation of larger groups is needed to determine the prevalence of antithyroid antibodies in the unique population of infertile women.
Geva
E
E
IVF Unit, Serlin Maternity Hospital, Sackler Faculty of Medicine, Tel Aviv University, Israel.
Lessing
J B
JB
Lerner-Geva
L
L
Azem
F
F
Yovel
I
I
Amit
A
A
D000328:Adult; D001323:Autoantibodies / Q000097:blood*; D005184:Fallopian Tube Diseases / Q000209:etiology* / Q000276:immunology*; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000209:etiology* / Q000276:immunology*; D008861:Microsomes / Q000276:immunology; D011247:Pregnancy; D013954:Thyroglobulin / Q000276:immunology; D013961:Thyroid Gland / Q000276:immunology* / Q000378:metabolism
D001323:Autoantibodies; D013954:Thyroglobulin