Derivative Y chromosome resulting from a t(Y;15) (q12;q11.2) in a boy with Prader-Willi syndrome.
Chromosome analysis of peripheral lymphocytes from a boy with Prader-Willi syndrome showed the presence of 45 chromosomes, including der(Y) resulting from a t(Y;15) (q12;q11.2). In situ hybridization using DYZ3 and D15S11 showed a positive signal and negative signal in derivative Y chromosome, respectively. The deficiency of 15pter q11.2 may not influence the clinical manifestation of Prader-Willi syndrome.
Suzuki
Y
Y
Department of Urology, Yamagata University, School of Medicine, Japan.
Sasagawa
I
I
Sawamura
T
T
Ishigooka
M
M
Kaneko
H
H
Kubota
Y
Y
Nakada
T
T
D002675:Child, Preschool; D002884:Chromosomes, Human, Pair 15 / Q000235:genetics*; D006801:Humans; D007006:Hypogonadism / Q000175:diagnosis / Q000235:genetics*; D017403:In Situ Hybridization; D007621:Karyotyping; D008214:Lymphocytes / Q000737:chemistry; D008297:Male; D011218:Prader-Willi Syndrome / Q000175:diagnosis / Q000235:genetics*; D014178:Translocation, Genetic; D014998:Y Chromosome / Q000235:genetics*