title: Characterization of clofazimine metabolites in humans by HPLC-electrospray mass spectrometry.
abstract: Clofazimine (CAS 2030-63-9) is an important drug used in the treatment of leprosy. Its important metabolites are investigated by thin layer chromatography (TLC), HPLC (diode array) and HPLC-electrospray mass spectrometry. The resulting analytical data, extraction, isolation and characterization methods are presented. Their applicability is described for human urine analysis.
authors.affiliation: Drug Metabolism Laboratory University College of Pharmaceutical Sciences, Kakatiya University, Warangal, India.
authors.forename: D R
authors.initials: DR
authors.lastname: Krishna
authors.forename: R N
authors.initials: RN
authors.lastname: Mamidi
authors.forename: U
authors.initials: U
authors.lastname: Hofmann
authors.forename: C M
authors.initials: CM
authors.lastname: Prabhakar
mesh_terms: D000328:Adult; D001711:Biotransformation; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D002991:Clofazimine / Q000493:pharmacokinetics* / Q000652:urine; D006801:Humans; D007917:Leprostatic Agents / Q000493:pharmacokinetics* / Q000652:urine; D008099:Liver / Q000201:enzymology; D008297:Male; D013058:Mass Spectrometry
chemical_list: D007917:Leprostatic Agents; D002991:Clofazimine