Collective binding properties of receptor arrays.
Binding kinetics of receptor arrays can differ dramatically from that of the isolated receptor. We simulate synaptic transmission using a microscopically accurate Brownian dynamics routine. We study the factors governing the rise and decay of the activation probability as a function of the number of transmitter molecules released. Using a realistic receptor array geometry, the simulation reproduces the time course of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor-mediated excitatory postsynaptic currents. A consistent interpretation of experimentally observed synaptic currents in terms of rebinding and spatial correlations is discussed.
Agmon
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Department of Physical Chemistry, Hebrew University, Jerusalem, Israel. agmon@batata.fh.huji.ac.il
Edelstein
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D000818:Animals; D001665:Binding Sites; D003198:Computer Simulation; D004058:Diffusion; D018690:Excitatory Amino Acid Agonists; D006624:Hippocampus / Q000378:metabolism; D007700:Kinetics; D008433:Mathematics; D009469:Neuromuscular Junction / Q000378:metabolism; D018377:Neurotransmitter Agents / Q000378:metabolism; D011485:Protein Binding; D051381:Rats; D018091:Receptors, AMPA / Q000378:metabolism; D011950:Receptors, Cholinergic / Q000378:metabolism; D017981:Receptors, Neurotransmitter / Q000378:metabolism*; D012984:Software; D009435:Synaptic Transmission; D018350:alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid / Q000378:metabolism
D018690:Excitatory Amino Acid Agonists; D018377:Neurotransmitter Agents; D018091:Receptors, AMPA; D011950:Receptors, Cholinergic; D017981:Receptors, Neurotransmitter; D018350:alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid