[Glucose--friend or foe of the hypoxic-ischemic brain?].
Glucose is the most important cerebral fuel. During severe hypoxia-ischemia anaerobic glycolysis may partly replace oxidative phosphorylation as a source of energy, and in this situation high glucose levels may improve energy production. Despite this, it has been shown convincingly that, in adult animals, a high glucose level before global, cerebral ischemia increases the damage. In newborn animals the results are species-dependent. The importance of postischemic glucose levels is more uncertain. Few clinical intervention studies have been carried out, but some tentative guidelines can nevertheless be suggested.
Rootwelt
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Barneklinikken, Rikshospitalet, Oslo.
D000328:Adult; D002545:Brain Ischemia / Q000378:metabolism*; D002648:Child; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D002534:Hypoxia, Brain / Q000378:metabolism*; D007223:Infant
D005947:Glucose
Glukose--venn eller fiende av den hypoksisk-iskemiske hjerne?