title: Comparison of uptake of 99mTc-alkylisonitriles in the rat 9L gliosarcoma tumor model.
abstract: The accumulation of three 99mTc(I) alkyl isonitriles was compared in vitro and in vivo using 9L gliosarcoma cells. In vitro, the uptake of 99mTc-EIBI and 99mTc-EPI was higher than that of 99mTc-MIBI. In vivo, however, there was no difference in the tumor concentration at 15 or 60 min postinjection and only a small difference at 24 h. The differences in uptake observed in vitro are apparently offset in vivo by differences in delivery of the tracers to the tumor.
authors.affiliation: Division of Nuclear Medicine, Children's Hospital, Boston, MA 02115, USA.
authors.forename: A B
authors.initials: AB
authors.lastname: Packard
authors.forename: E
authors.initials: E
authors.lastname: Barbarics
authors.forename: J F
authors.initials: JF
authors.lastname: Kronauge
authors.forename: P Y
authors.initials: PY
authors.lastname: Wen
authors.forename: P J
authors.initials: PJ
authors.lastname: Day
authors.forename: A G
authors.initials: AG
authors.lastname: Jones
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000000981:diagnostic imaging / Q000378:metabolism*; D018316:Gliosarcoma / Q000000981:diagnostic imaging / Q000378:metabolism*; D008297:Male; D009570:Nitriles / Q000493:pharmacokinetics*; D015609:Organotechnetium Compounds / Q000493:pharmacokinetics*; D011877:Radionuclide Imaging; D051381:Rats; D017256:Technetium Tc 99m Sestamibi / Q000493:pharmacokinetics*; D014018:Tissue Distribution; D014407:Tumor Cells, Cultured
chemical_list: D009570:Nitriles; D015609:Organotechnetium Compounds; C105923:technetium Tc 99m ethoxypropylisonitrile; C105922:technetium Tc 99m ethoxyisobutylisonitrile; D017256:Technetium Tc 99m Sestamibi