title: [Peritoneal and subcutaneous administration of cefazolin as perioperative antibiotic prophylaxis in colorectal operations. Prospective randomized comparative study of 200 patients].
abstract: The prophylactic effect of a intraoperative intraperitoneal and subcutaneous application of cefazolin versus a single shot i.v. prophylaxis was investigated. Additionally, we registered the concentration of cefazolin in the serum and the peritoneal fluid in 22 patients. We randomized 200 patients of whom 189 were included in the study. Ninety-two patients received the prophylaxis i.v. (group 1) and 97 topically (group 2). In 4 (2.1%) wound infections occurred [3(3.3%) group 1 and 1 (1.0%) in group 2]. The difference was not significant. The concentration of cefazolin in the serum was significantly higher at 1 h and 2 h postoperatively in group 2. We conclude that a topical application of antibiotics is possible to prevent surgical wound infection.
authors.affiliation: Klinik für Gefässchirurgie am Katharinenhospital, Stuttgart.
authors.forename: J
authors.initials: J
authors.lastname: Quendt
authors.forename: I
authors.initials: I
authors.lastname: Blank
authors.forename: W
authors.initials: W
authors.lastname: Seidel
mesh_terms: D000368:Aged; D019072:Antibiotic Prophylaxis; D001682:Biological Availability; D002437:Cefazolin / Q000008:administration & dosage* / Q000009:adverse effects / Q000493:pharmacokinetics; D002511:Cephalosporins / Q000008:administration & dosage* / Q000009:adverse effects / Q000493:pharmacokinetics; D015179:Colorectal Neoplasms / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D007274:Injections, Intraperitoneal; D007275:Injections, Intravenous; D007279:Injections, Subcutaneous; D008297:Male; D011446:Prospective Studies; D013530:Surgical Wound Infection / Q000097:blood / Q000517:prevention & control*
chemical_list: D002511:Cephalosporins; D002437:Cefazolin
vernacular_title: Peritoneale und subkutane Applikation von Cefazolin als perioperative Antibiotikaprophylaxe bei kolorektalen Operationen. Prospektive randomisierte Vergleichsstudie bei 200 Patienten.