Aortic vessel wall characteristics and blood pressure in children with intrauterine growth retardation and abnormal foetal aortic blood flow.
Blood pressure and pulsatile diameter changes of the abdominal aorta were measured in 68 children (mean age 9 years), with varying degrees of intrauterine growth retardation who were previously examined in their intrauterine life with Doppler velocimetry of the thoracic descending aorta. Diastolic blood pressure was lower (p < 0.05) and pulse pressure was increased (p < 0.01) in children with a birthweight small for gestational age as compared to those with a birthweight appropriate for gestational age. Systolic blood pressure was positively associated with relative increase in weight from birth up to the time of examination (p < 0.01), but not to early catch-up growth. Aortic vessel wall diameters were smaller in children born small for gestational age, both before and after correction for current body surface area (p < 0.01). Blood pressure and aortic vessel wall characteristics exhibited no relationship to the foetal aortic Doppler wave-form. Changes in foetal haemodynamics associated with intrauterine growth retardation do not appear to contribute to a later increase in blood pressure. Within a group of foetuses with suspected growth retardation, increasing foetal weight deviation and a birthweight small for gestational age is associated with lower diastolic blood pressure at 9 years of age.
Ley
D
D
Department of Pediatrics, Lund University Hospital, Sweden.
Stale
H
H
Marsal
K
K
D000886:Anthropometry; D001012:Aorta, Abdominal / Q000196:embryology* / Q000502:physiology*; D001783:Blood Flow Velocity; D001794:Blood Pressure; D001835:Body Weight; D002648:Child; D002675:Child, Preschool; D005317:Fetal Growth Retardation / Q000175:diagnosis*; D005865:Gestational Age; D006439:Hemodynamics; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D011446:Prospective Studies; D012923:Social Class