Activity of IFN-gamma in experimental Leishmania infantum murine visceral leishmaniasis.
The effect of recombinant interferon-gamma (rIFN-gamma) on Leishmania infantum infection was investigated in vivo. BALB/c mice were injected intravenously (i.v.) with 10(7) promastigotes of Leishmania infantum. rIFN-gamma, 10(6) U given intraperitoneally (i.p.) daily on 3 consecutive days or 4 times on alternate days from day 7 (d7) post infection, had no detectable effect on the parasite burdens in liver, spleen, and lungs as compared to untreated mice. However rIFN-gamma enhanced the activity of Glucantime (50 mg/kg/d intraperitoneally for 7 days) in the liver and in the lungs. The additive effect of rIFN-gamma was still observed at day 30 post-infection, i.e. 15 days after cessation of therapy. By contrast the combination of the two drugs had no activity against splenic parasites.
Garin
Y J
YJ
Laboratoire de Parasitologie-Mycologie, Faculté de Médecine Lariboisière-Saint Louis, Paris, France.
Sulahian
A
A
Gangneux
J P
JP
Derouin
F
F
D000818:Animals; D000981:Antiprotozoal Agents / Q000008:administration & dosage / Q000494:pharmacology*; D004195:Disease Models, Animal; D004334:Drug Administration Schedule; D005260:Female; D007371:Interferon-gamma / Q000008:administration & dosage / Q000494:pharmacology*; D018314:Leishmania infantum / Q000187:drug effects*; D007898:Leishmaniasis, Visceral; D008099:Liver / Q000382:microbiology; D008168:Lung / Q000382:microbiology; D008536:Meglumine / Q000494:pharmacology; D000077485:Meglumine Antimoniate; D051379:Mice; D008807:Mice, Inbred BALB C; D009942:Organometallic Compounds / Q000494:pharmacology; D011994:Recombinant Proteins; D013154:Spleen / Q000382:microbiology
D000981:Antiprotozoal Agents; D009942:Organometallic Compounds; D011994:Recombinant Proteins; D008536:Meglumine; D000077485:Meglumine Antimoniate; D007371:Interferon-gamma