Wound healing following radiation therapy: a review.
Radiation therapy may interrupt normal wound healing mechanisms. Changes in vasculature, effects on fibroblasts, and varying levels of regulatory growth factors result in the potential for altered wound healing whether radiation is given before or after surgery. Surgical factors, such as incision size, as well as radiation parameters, including dose and fractionation, are important considerations in developing overall treatment plans. Experience suggests that certain practical measures may diminish the risk of morbidity, and investigations are ongoing.
Tibbs
M K
MK
Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA.
D002455:Cell Division / Q000502:physiology; D005347:Fibroblasts / Q000502:physiology / Q000528:radiation effects; D006801:Humans; D011183:Postoperative Complications / Q000503:physiopathology; D011832:Radiation Injuries / Q000503:physiopathology; D011878:Radiotherapy / Q000009:adverse effects; D012867:Skin / Q000528:radiation effects*; D014945:Wound Healing / Q000502:physiology / Q000528:radiation effects*; D014947:Wounds and Injuries / Q000503:physiopathology