title: Malignant change in an intradiploic epidermoid cyst.
abstract: We describe a unique case of an intra-diploic epidermoid cyst of the parietal and occipital right bone in a 43 year-old man. The tumor remained quiescent for 12 years and then spontaneously showed malignant changes with intra-cerebral involvement. Fatal outcome occurred one year after surgery, radiation therapy and chemotherapy because of a recurrence. Malignant transformation of the epithelium in epidermoid cyst is very rare. Our case is the first one where this transformation occurred spontaneously without previous surgery.
authors.affiliation: Department of Radiology, Hôpital Jeanne d'Arc, Toul, France.
authors.forename: C
authors.initials: C
authors.lastname: Hoeffel
authors.forename: N
authors.initials: N
authors.lastname: Heldt
authors.forename: C
authors.initials: C
authors.lastname: Chelle
authors.forename: M
authors.initials: M
authors.lastname: Claudon
authors.forename: J C
authors.initials: JC
authors.lastname: Hoeffel
mesh_terms: D000328:Adult; D001845:Bone Cysts / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D002294:Carcinoma, Squamous Cell / Q000473:pathology* / Q000628:therapy; D002471:Cell Transformation, Neoplastic; D003131:Combined Modality Therapy; D004814:Epidermal Cyst / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D011859:Radiography; D012888:Skull Neoplasms / Q000473:pathology* / Q000628:therapy