title: [Immunomodulation after parenteral glutamine administration in colorectal surgery].
abstract: The influence of parenteral L-alanyl-L-glutamine dipeptide on the cysteinyl-leukotriene (cys-LT) synthesizing capacity from neutrophils was studied in patients undergoing colonic surgery. The decrease in cys-LT, observed postoperatively, could be normalized with parenteral glutamine, while the cys-LT decrease persisted in controls. We conclude that the provision of glutamine in the postoperative state improves normalization of neutrophil functions (e.g., generation of cys-LT), which is an essential prerequisite for host defences.
authors.affiliation: Klinik für Anästhesiologie und operative Intensivmedizin, Ruhr-Universität Bochum.
authors.forename: B J
authors.initials: BJ
authors.lastname: Morlion
authors.forename: H P
authors.initials: HP
authors.lastname: Siedhoff
authors.forename: U
authors.initials: U
authors.lastname: Joosten
authors.forename: M
authors.initials: M
authors.lastname: Köller
authors.forename: W
authors.initials: W
authors.lastname: König
authors.forename: P
authors.initials: P
authors.lastname: Fürst
authors.forename: C
authors.initials: C
authors.lastname: Puchstein
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003110:Colonic Neoplasms / Q000276:immunology / Q000601:surgery*; D004151:Dipeptides / Q000008:administration & dosage*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D015289:Leukotrienes / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000276:immunology*; D010289:Parenteral Nutrition, Total; D011183:Postoperative Complications / Q000276:immunology*
chemical_list: D004151:Dipeptides; D015289:Leukotrienes; C054122:alanylglutamine
vernacular_title: Immunmodulation nach parenteraler Glutaminzufuhr in der Dickdarmchirurgie.