Cra and the control of carbon flux via metabolic pathways.
The catabolite repressor-activator (Cra) protein controls the direction of carbon flux through metabolic pathways in enteric bacteria. Cra binds to the control regions of target genes and exerts a negative effect on the expression of genes encoding glycolytic and Entner-Doudoroff enzymes, while exerting a positive effect on genes encoding Krebs cycle, glyoxylate shunt and gluconeogenic enzymes. Cra mediates cyclic AMP-independent catabolite repression of positively Cra-regulated genes and catabolite activation of negatively Cra-controlled genes.
Ramseier
T M
TM
Department of Biology, University of California at San Diego, La Jolla 92093-0116, USA.
D001419:Bacteria / Q000235:genetics / Q000378:metabolism*; D001426:Bacterial Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D050260:Carbohydrate Metabolism; D015964:Gene Expression Regulation, Bacterial; D066298:In Vitro Techniques; D012097:Repressor Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D056968:Lac Repressors
D001426:Bacterial Proteins; D012097:Repressor Proteins; C068837:FruR protein, Bacteria; D056968:Lac Repressors