5-Fluorouracil reduces scarring after strabismus surgery.
OBJECTIVE
To examine the effect of topically administered 5-fluorouracil during strabismus surgery on post-operative scarring and the strength of the tendon-muscle union.


METHODS
Bilateral superior and inferior rectus muscle recessions were performed on 10 Stauffland white rabbits. The operated muscles in one eye received a 5-min topical application of 50 mg/mL solution of 5-fluorouracil (5-FU). The fellow eye received placebo treatment with a 5-min application of balanced sterile saline. Both eyes were enucleated 29 days postoperatively and examined for evidence of scarring. The tensile strength of both treated and untreated muscles was measured. Two additional rabbits received no surgery but had their eyes enucleated to serve as controls for tensile strength measurements.


RESULTS
A significant reduction (P = 0.0001) in the amount of scarring was noted in eyes treated with 5-FU. A reduction in the tensile strength of both operated groups compared with the unoperated groups (P = 2.72 x 10(-12)) was noted, with a small but significant difference between the two operated groups (P = 0.0423).


CONCLUSIONS
This study suggests that 5-FU may be a useful adjunctive therapy in strabismus surgery, especially when extensive postoperative scarring is expected.
Andreo
L K
LK
Fitzsimons Army Medical Center, Department of Ophthalmology, Aurora, Colorado, USA.
Uyemura
M J
MJ
Enzenauer
R W
RW
D000287:Administration, Topical; D000818:Animals; D000963:Antimetabolites / Q000008:administration & dosage / Q000627:therapeutic use*; D002921:Cicatrix / Q000503:physiopathology / Q000517:prevention & control*; D004195:Disease Models, Animal; D005472:Fluorouracil / Q000008:administration & dosage / Q000627:therapeutic use*; D005500:Follow-Up Studies; D007432:Intraoperative Period; D009801:Oculomotor Muscles / Q000503:physiopathology / Q000601:surgery; D009883:Ophthalmic Solutions; D011183:Postoperative Complications / Q000517:prevention & control; D011817:Rabbits; D013285:Strabismus / Q000601:surgery*; D013718:Tensile Strength / Q000502:physiology
D000963:Antimetabolites; D009883:Ophthalmic Solutions; D005472:Fluorouracil