Beta-carotene did not work: aftermath of the ATBC study.
The results of the ATBC study, the first large intervention trial of antioxidants, were intriguing. While the possibility that beta-carotene may in some circumstances enhance carcinogenesis has now been confirmed in another large trial, the mechanisms of action remain obscure.
Rautalahti
M
M
National Public Health Institute, Helsinki, Finland. matti.rautalahti@ktl.fi
Albanes
D
D
Virtamo
J
J
Taylor
P R
PR
Huttunen
J K
JK
Heinonen
O P
OP
D000368:Aged; D006801:Humans; D008175:Lung Neoplasms / Q000517:prevention & control*; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000517:prevention & control; D012907:Smoking; D014810:Vitamin E / Q000627:therapeutic use; D019207:beta Carotene / Q000627:therapeutic use*
D019207:beta Carotene; D014810:Vitamin E