title: [Effect of anthocyanins on human connective tissue metabolism in the human].
abstract: BACKGROUND
  Diabetic retinopathy can lead to blindness. This is due to an abnormally increased synthesis of connective tissue in order to a) repair leaking capillaries and b) formation of new capillaries.
  
  
  METHODS
  Twelve adult diabetics were treated with 600 mg anthocyanosides per day for two months. Samples of gingiva tissue were taken before and after treatment. Incubated with radio-active labeled amino acids, the measure of radioactivity from different connective tissue extracts can show a changed protein biosynthesis activity.
  
  
  RESULTS
  The use of radio-active labeled amino acids show significant decrease of biosynthesis-activity of connective tissue especially polymeric collagen and structure-glycoproteins by anthocyanoside medication.
  
  
  CONCLUSIONS
  Anthocyanosides help to prevent diabetics from injuries caused by malfunction of synthesis-activities throughout normal diabetic medical treatment.
authors.affiliation: Labor für Bindegewebsbiochemie, Medizinische Fakultät, Universität Paris, Val de Marne.
authors.forename: R
authors.initials: R
authors.lastname: Boniface
authors.forename: A M
authors.initials: AM
authors.lastname: Robert
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000872:Anthocyanins / Q000008:administration & dosage*; D001485:Basement Membrane / Q000187:drug effects / Q000473:pathology; D001813:Blood-Retinal Barrier / Q000187:drug effects; D003238:Connective Tissue / Q000187:drug effects / Q000473:pathology; D003930:Diabetic Retinopathy / Q000188:drug therapy* / Q000473:pathology; D005109:Extracellular Matrix / Q000187:drug effects / Q000473:pathology; D005260:Female; D006025:Glycosaminoglycans / Q000378:metabolism*; D006801:Humans; D008297:Male
chemical_list: D000872:Anthocyanins; D006025:Glycosaminoglycans
vernacular_title: Einfluss von Anthocyanen auf den Bindegewebsmetabolismus beim Menschen.