[Chronic treatment with tween-80 (5%) or n-stearoyl glycine on the antimobility effects of imipramine in the forced swimming test in mice].
Chronic (7 days) administration of N-stearoyl glycine (SG) or Tween-80 (5%) suppress the antiimmobility effect of Imipramine, in the forced swimming test on mice, whereas the antiimmobility effect of SG is suppressed only after chronic treatment with SG. These results suggest that chronic SG treatment could desensitize the glycinergic site of the NMDA receptors and that chronic Tween-80 (5%) administration could inactivate the glutamatergic site of the NMDA receptors or disturb some modulation, other than glycinergic, of the NMDA ionic channel. The latter could be important in an environmental or experimental viewpoint.
Vamvakidès
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A
Laboratoire de pharmacologie expérimentale-Faculté de Médecine d'Athènes, Grèce.
D000818:Animals; D000929:Antidepressive Agents, Tricyclic / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D005079:Excipients / Q000494:pharmacology*; D007099:Imipramine / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D008297:Male; D051379:Mice; D009068:Movement / Q000187:drug effects; D011136:Polysorbates / Q000494:pharmacology*; D016194:Receptors, N-Methyl-D-Aspartate / Q000187:drug effects; D013229:Stearic Acids / Q000494:pharmacology*; D013550:Swimming
D000929:Antidepressive Agents, Tricyclic; D005079:Excipients; D011136:Polysorbates; D016194:Receptors, N-Methyl-D-Aspartate; D013229:Stearic Acids; C104915:N-stearoylglycine; D007099:Imipramine
Le traitement chronique par le Tween-80 (5%) n'affecte pas l'effect antiimmobilité de la N-stéaroyl glycine, mais supprime celui de l'Imipramine, au test de la nage forcée chez la souris.