Flavonol and chalcone ester glycosides from Bidens leucantha.
Four new flavonol 7-O-glycosides 1-4 and a new chalcone ester glycoside 5 have been isolated from the leaves of Bidens leucantha along with four known chalcone ester glycosides 6-9. Their structures were elucidated using a combination of spectroscopic techniques. The in vitro anti-HIV activity of all the compounds was tested as part of our screening of potential anti-AIDS agents from medicinal plants. Although none of the flavonol glycosides was active, a moderate inhibitory effect on viral replication was exerted by chalcone ester glycoside 9.
De Tommasi
N
N
Centro Interdipartimentale di Chimica, Biologia e Technologie Farmaceutiche, Università degli Studi di Salerno, Italy.
Pizza
C
C
Aquino
R
R
Cumandà
J
J
Mahmood
N
N
D019380:Anti-HIV Agents / Q000302:isolation & purification* / Q000494:pharmacology; D002460:Cell Line; D002599:Chalcone / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D044948:Flavonols; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015497:HIV-1 / Q000187:drug effects; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D010946:Plants, Medicinal / Q000737:chemistry*; D016339:Spectrometry, Mass, Fast Atom Bombardment; D014779:Virus Replication / Q000187:drug effects
D019380:Anti-HIV Agents; D005419:Flavonoids; D044948:Flavonols; D006027:Glycosides; D002599:Chalcone