title: [Preliminary study of the safety and immunogenicity of the attenuated VD47/25 strain of camelpoxvirus].
abstract: The safety and immunogenicity of the attenuated VD47/25 strain of camelpoxvirus were tested on 30 camel calves in Mauritania. Post-inoculation clinical symptoms were absent during the 40 days of observation. Serum samples collected during this period showed low levels of neutralizing antibodies (1/4-1/16). In vivo titration of a virulent strain of camelpoxvirus in vaccinated camels and control animals enabled the calculation of the PD50 (50% protective dose) which contained the equivalent of 10(3.7) TCID50 (50% cell culture infective dose). Other studies are still required to determine the dose of this vaccine needed to protect 95% of vaccinated animals.
authors.affiliation: CIRAD-EMVT, Montpellier, France.
authors.lastname: Nguyen-Ba-Vy
authors.forename: L
authors.initials: L
authors.lastname: Guerre
authors.forename: G
authors.initials: G
authors.lastname: Saint-Martin
mesh_terms: D000818:Animals; D002162:Camelus; D011212:Poxviridae / Q000276:immunology*; D014613:Vaccines, Attenuated / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology; D014765:Viral Vaccines / Q000008:administration & dosage* / Q000009:adverse effects / Q000276:immunology
chemical_list: D014613:Vaccines, Attenuated; D014765:Viral Vaccines
vernacular_title: Etude préliminaire de l'innocuité et du pouvoir immunogène de la souche atténuée VD47/25 de camelpoxvirus.