title: [Suppression of the reproduction of the human immunodeficiency virus (HIV) with a cytokine-like antiviral factor].
abstract: Cytokine-like antivirus factor, obtained from the culture fluid of chick embryo fibroblasts, was found to possess inhibitory activity with respect to HIV-1 (strains 1/Zmb and RF). The treatment of HIV-infected cell culture with cytokine-like factor was accompanied by a decrease in the cytopathic effect of the agent without manifestations of cytotoxicity. The combined use of the cytokine-like factor and azidothymidine at near-threshold concentrations was not accompanied by an increase in the antivirus effect, observed after the use of each preparation separately.
authors.forename: N V
authors.initials: NV
authors.lastname: Gribkova
authors.forename: V F
authors.initials: VF
authors.lastname: Eremin
authors.forename: V I
authors.initials: VI
authors.lastname: Votiakov
authors.forename: M Iu
authors.initials: MIu
authors.lastname: Shchelkanov
authors.forename: T A
authors.initials: TA
authors.lastname: Pashkova
authors.forename: E V
authors.initials: EV
authors.lastname: Karamov
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000302:isolation & purification / Q000494:pharmacology*; D002642:Chick Embryo; D003470:Culture Media; D016207:Cytokines / Q000302:isolation & purification / Q000494:pharmacology*; D003588:Cytopathogenic Effect, Viral / Q000187:drug effects; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D015497:HIV-1 / Q000187:drug effects* / Q000502:physiology; D014776:Virus Cultivation; D014779:Virus Replication / Q000187:drug effects*; D015215:Zidovudine / Q000494:pharmacology
chemical_list: D000998:Antiviral Agents; D003470:Culture Media; D016207:Cytokines; D015215:Zidovudine
vernacular_title: Podavlenie reproduktsii virusa immunodefitsita cheloveka (VICh) tsitokinopodobnym antivirusnym faktorom.