[Renal function and histologic findings in immunoglobulin A nephropathy].
We investigated 28 patients with IgA nephropathy. Discriminatory analysis was the method used to determine discriminatory power of certain clinical and pathohistological parameters. Semiquantitatively were determined pathohistological parameters: glomerular index in range 0-10, vascular index 1-4, interstitial fibrosis 0-10, interstitial infiltration 0-3, tubular atrophy 0-3. Nephrotic syndrome (symbolic value), quantitative proteinuria and creatinine clearance at the time of biopsy and year after (continual variable) were used as clinical parameters. Discriminatory power was determined as a degree of decreasing Shennon's entropy by distinction of patients according to value of creatinine clearance at the time of biopsy, and a year after biopsy. Discriminatory power was measured in he information measurement units (bit). Based on discriminatory-predictive analysis we determined that glomerula changes and interstitial fibrosis had an equal effect (discriminatory power) on renal function at the time of biopsy and a year latter, as well as predictive value of these histological parameters and creatinine clearance at the time of biopsy.
Banković-Calić
N
N
Institute of Urology and Nephrology, Clinical Centre of Serbia, Belgrade.
Sindjić
M
M
Milosavljević
M
M
Pavlović
S
S
Velimirović
D
D
Djukonović
Lj
Lj
D000328:Adult; D003404:Creatinine / Q000378:metabolism; D005260:Female; D005922:Glomerulonephritis, IGA / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D007668:Kidney / Q000473:pathology / Q000503:physiopathology; D008297:Male
D003404:Creatinine
Funcija bubrega i histoloski nalaz u nefropatiji imunoglbulina A.