A novel approach to reduce the unwanted gastric side-effects of orally administered non-steroidal anti-inflammatory drugs in rats.
Among experimental circumstances both cysteine and glutathione, given in the same time as indomethacin or piroxicam, are capable to decrease the unwanted gastric side-effects of the non-steroidal anti-inflammatory drugs. Similar effects were encountered with prostacyclin or D-penicillamine therapy as well but additional prostacyclin therapy is expensive and complicated (its biological half-life is too short;) D-penicillamine has numerous other, non gastrointestinal side-effects, therefore these two latter substances seem to be inferior compared to the previously mentioned ones. Therefore we conclude that in the human non-steroidal anti-inflammatory therapy it would be worthwhile to apply those drugs with a small amount of either cysteine or glutathione to decrease their unwanted side-effects. This assumption is strengthened by the fact that neither cysteine nor glutathione is an unnatural material in the body.
Balint
G A
GA
Department of Neurology and Psychiatry, Albert Szent-Györgyi Medical University, Szeged, Hungary.
D000284:Administration, Oral; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000009:adverse effects*; D003545:Cysteine / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D011464:Epoprostenol / Q000627:therapeutic use; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects*; D005767:Gastrointestinal Diseases / Q000139:chemically induced / Q000188:drug therapy / Q000517:prevention & control*; D005978:Glutathione / Q000627:therapeutic use*; D007213:Indomethacin / Q000008:administration & dosage / Q000009:adverse effects*; D010396:Penicillamine / Q000627:therapeutic use; D010894:Piroxicam / Q000008:administration & dosage / Q000009:adverse effects*; D051381:Rats; D017208:Rats, Wistar
D000894:Anti-Inflammatory Agents, Non-Steroidal; D010894:Piroxicam; D011464:Epoprostenol; D005978:Glutathione; D010396:Penicillamine; D003545:Cysteine; D007213:Indomethacin