title: Agreement between peripheral venous and arterial lactate levels.
abstract: OBJECTIVE
  To test the hypothesis that measurements of peripheral venous lactate (V-LACT) can be substituted for arterial lactate (A-LACT) in predicting arterial hyperlactacidemia.
  
  
  METHODS
  We conducted a prospective comparison of paired A-LACT and V-LACT measurements obtained from a convenience sample of 74 ED patients who presented to an urban, public teaching hospital, 70% of whom had abnormal A-LACT.
  
  
  RESULTS
  Mean A-LACT and V-LACT were 2.8 mmol/L and 3.0 mmol/L, respectively. A-LACT and V-LACT were strongly correlated (r2 = .89). Simultaneous multivariate adjustment for tourniquet time and for time elapsed between drawing of A-LACT and V-LACT had no effect on this correlation. Although the mean difference between V-LACT and A-LACT was only .22 mmol/L, the range that included 95% of the disagreement between paired measurements in individual patients was-1.3 mmol/L to 1.7 mmol/L. When A-LACT and V-LACT levels were each divided into normal and abnormal (elevated) groups, V-LACT showed 94% sensitivity (95% confidence interval [CI], 83% to 99%), 57% specificity (95% CI, 34% to 78%), a positive likelihood ratio of 2.2, and a negative likelihood ratio of .1. A-LACT values were used as the criterion standard for these calculations.
  
  
  CONCLUSIONS
  Correlation between A-LACT and V-LACT was high in this cohort of patients, but agreement is imperfect. The odds of arterial hyperlactacidemia appear to be reduced substantially by the finding of a normal V-LACT but are only marginally increased if the V-LACT is increased. Caution should be used in the routine substitution of V-LACT for A-LACT.
authors.affiliation: Department of Emergency Medicine, Albert Einstein College of Medicine, Bronx, New York, USA. ejg@ix.netcom.com
authors.forename: E J
authors.initials: EJ
authors.lastname: Gallagher
authors.forename: K
authors.initials: K
authors.lastname: Rodriguez
authors.forename: M
authors.initials: M
authors.lastname: Touger
mesh_terms: D000140:Acidosis, Lactic / Q000097:blood*; D000293:Adolescent; D000328:Adult; D000368:Aged; D001158:Arteries; D001784:Blood Gas Analysis / Q000379:methods; D015331:Cohort Studies; D016001:Confidence Intervals; D005260:Female; D006801:Humans; D007773:Lactates / Q000097:blood*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D013997:Time Factors; D014111:Tourniquets; D014680:Veins
chemical_list: D007773:Lactates