[The effect of unilateral destruction of the caudate nucleus with kainic acid on the nature of the electrical activity in the rat brain in the wakefulness-sleep cycle].
The spectral and correlative analysis of the EEG of several brain structures (caudate nucleus, hippocamp, somatosensory, visual and auditory areas) in the wakefulness-sleep cycle in Wistar rats after the unilateral selective local lesions of the neurones in the head of the caudate nucleus with kainic acid was made. It was shown that after injection with kainic acid the spectral and correlative EEG parameters in rats during the wakefulness, slow-wave and fast-wave sleep were essentially normal. At the same time the burst of spindle-like activity from alpha-range and epileptiform discharges of typical multiple spikes were observed during the fast-wave sleep. This activity appearance in rats is considered as a result of the level of striatal inhibitory influences decreasing on the thalamus and hippocamp after the lesions of the head of the caudate nucleus in these animals.
Vataev
S I
SI
Titkov
E S
ES
Oganesian
G A
GA
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000502:physiology; D002421:Caudate Nucleus / Q000187:drug effects* / Q000502:physiology; D004567:Electrodes, Implanted; D004569:Electroencephalography / Q000187:drug effects / Q000706:statistics & numerical data; D004594:Electrophysiology; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology*; D007608:Kainic Acid / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012815:Signal Processing, Computer-Assisted; D012890:Sleep / Q000187:drug effects* / Q000502:physiology; D013997:Time Factors; D014851:Wakefulness / Q000187:drug effects* / Q000502:physiology
D018691:Excitatory Amino Acid Antagonists; D007608:Kainic Acid
Vliianie odnostoronnego razrusheniia khvostogo iadra kainovoĭ kisloty na kharakter élektricheskoĭ aktivnosti golovnogo mozga krys v tsikle bodrstvovanie--son.