title: Clinical assessment of fluorescence cytoscopy during transurethral bladder resection in superficial bladder cancer.
abstract: The prognosis of superficial bladder cancer in terms of recurrence and disease progression is related to bladder tumor multiplicity and the presence of concomitant "plane" tumors such as high-grade dysplasia and carcinoma in situ. This study in 33 patients aimed to demonstrate the role of fluorescence cystoscopy in transurethral resection of superficial bladder cancer. The method is based on the detection of protoporphyrin-IX-induced fluorescence in urothelial cancer cells by topical administration of 5-aminolevulinic acid. The sensitivity and the specificity of this procedure on apparently normal mucosa in superficial bladder cancer are estimated to be 82.9% and 81.3%, respectively. Thus, fluorescence cytoscopy is a simple and reliable method for mapping the bladder mucosa, especially in the case of multifocal bladder disease, and it facilitates the screening of occult dysplasia.
authors.affiliation: Department of Urology, University Hospital, Lausanne, Switzerland.
authors.forename: P
authors.initials: P
authors.lastname: Jichlinski
authors.forename: G
authors.initials: G
authors.lastname: Wagnières
authors.forename: M
authors.initials: M
authors.lastname: Forrer
authors.forename: J
authors.initials: J
authors.lastname: Mizeret
authors.forename: L
authors.initials: L
authors.lastname: Guillou
authors.forename: M
authors.initials: M
authors.lastname: Oswald
authors.forename: F
authors.initials: F
authors.lastname: Schmidlin
authors.forename: P
authors.initials: P
authors.lastname: Graber
authors.forename: H
authors.initials: H
authors.lastname: Van den Bergh
authors.forename: H J
authors.initials: HJ
authors.lastname: Leisinger
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000622:Aminolevulinic Acid / Q000008:administration & dosage; D002295:Carcinoma, Transitional Cell / Q000737:chemistry / Q000175:diagnosis*; D020684:Cystoscopes; D003558:Cystoscopy / Q000379:methods*; D005069:Evaluation Studies as Topic; D005260:Female; D005453:Fluorescence; D006801:Humans; D007726:Krypton; D008297:Male; D008875:Middle Aged; D017319:Photosensitizing Agents / Q000032:analysis; D011524:Protoporphyrins / Q000032:analysis; D012680:Sensitivity and Specificity; D001743:Urinary Bladder / Q000737:chemistry; D001749:Urinary Bladder Neoplasms / Q000737:chemistry / Q000175:diagnosis*; D014556:Urine / Q000166:cytology; D014978:Xenon
chemical_list: D017319:Photosensitizing Agents; D011524:Protoporphyrins; D014978:Xenon; D007726:Krypton; D000622:Aminolevulinic Acid; C028025:protoporphyrin IX