Symptom base rates after chemical exposure for white, Hispanic and African-Americans.
The results of a symptom checklist of three matched-pair studies (N = 460) of the following exposed groups are presented: Study 1, a primarily white community (N = 220) environmentally exposed to the pesticide metam sodium; Study 2, a Hispanic group (N = 180) who worked in a microelectronics plant and had extensive past exposure (M = 6.7 yrs) to multiple organic hydrocarbon solvents; and Study 3, an African-American group (N = 168) environmentally exposed to sulfuric acid. Each exposed group was compared to a matched (race, age +/- 3 years, gender, education +/- 2 years and number of children) unexposed reference group, resulting in 90 pairs for the white metam sodium group, 62 pairs for the Hispanic organic solvent group, and 78 pairs for the African-American sulfuric acid group. Symptom prevalence rates and relative risk ratios show very strong associations: in Study 1, the relative risk for all 33 symptoms ranged from 1.5 to 37; in Study 2, the relative risk for 31 of the symptoms ranged from 1.5 to 11.1; and in Study 3, the relative risk for 16 of the symptoms ranged from 1.5 to 6. Mann Whitney U results of each symptom indicate significantly greater symptomatology in the exposed vs. the reference groups in all three studies: in Study 1, at p < .01 for all 33 symptoms; in Study 2, at p < .01 for 31 symptoms, and p < .05 for one additional symptom; and in Study 3, at p < .01 for 24 symptoms and p < .05 for another three symptoms. These results suggest a robust symptom complex following chemical exposure regardless of specific chemical.
Bowler
R M
RM
San Francisco State University, I.N.S.E.R.M., Paris, France.
Huel
G
G
Mergler
D
D
Cone
J E
JE
Rauch
S S
SS
Hartney
C
C
D000328:Adult; D044383:Black People; D004781:Environmental Exposure; D005260:Female; D006630:Hispanic or Latino; D006801:Humans; D008297:Male; D008875:Middle Aged; D009420:Nervous System / Q000187:drug effects*; D009498:Neurotoxins / Q000633:toxicity*; D012997:Solvents / Q000633:toxicity*; D013464:Sulfuric Acids / Q000633:toxicity*; D013859:Thiocarbamates / Q000633:toxicity*; D044465:White People; D001741:Black or African American
D009498:Neurotoxins; D012997:Solvents; D013464:Sulfuric Acids; D013859:Thiocarbamates; C008435:methyldithiocarbamate; C033158:sulfuric acid