T lymphocyte beta 2-adrenergic receptor function and density after acute myocardial infarction.
The T lymphocyte beta 2-adrenergic receptor (beta 2AR) density and function were compared in 15 patients suffering acute myocardial infarction and 10 patients with stable coronary artery disease (CAD). Density was determined using radioligand binding with 125IPIN, and function by in vitro cyclic adenosine 3',5'-monophosphate (cAMP) production. In patients suffering acute myocardial infarction, T lymphocyte beta 2AR density (823.8 +/- 480 sites/cell) was slightly but not significantly different from that in patients with stable CAD (629 +/- 301 sites/cell). There was no difference in T lymphocyte cAMP production at baseline (1.11 +/- 0.70 vs 1.04 +/- 0.49 pM/10(6) cells) or after isoproterenol stimulation (2.53 +/- 1.63 vs 2.62 +/- 2.05 pM/10(6) cells), respectively. Further study is necessary to determine if beta 2AR numbers on T lymphocytes are significantly increased after acute myocardial infarction.
McCoy
R A
RA
College of Pharmacy, University of Kentucky, Lexington, USA.
Clifton
G D
GD
Booth
D C
DC
Bartels
L A
LA
Chandler
M H
MH
D000368:Aged; D002395:Catecholamines / Q000097:blood; D002940:Circadian Rhythm; D003327:Coronary Disease / Q000097:blood; D000242:Cyclic AMP / Q000096:biosynthesis; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood*; D018343:Receptors, Adrenergic, beta-2 / Q000378:metabolism*; D013601:T-Lymphocytes / Q000378:metabolism*
D002395:Catecholamines; D018343:Receptors, Adrenergic, beta-2; D000242:Cyclic AMP