title: Effect of glucagon on renal excretion of oxypurinol and purine bases.
abstract: OBJECTIVE
  To investigate whether glucagon increases the urinary excretion of oxypurinol and purine bases.
  
  
  METHODS
  We administered 1 mg glucagon intravenously to 5 healthy subjects taking 300 mg allopurinol orally, and determined plasma concentrations and urinary excretion of oxypurinol and purine bases.
  
  
  RESULTS
  Glucagon increased the urinary excretion and fractional clearances of uric acid, xanthine, and oxypurinol, together with an increase in creatinine clearance, while it decreased plasma concentrations of xanthine and hypoxanthine.
  
  
  CONCLUSIONS
  Glucagon-induced increases in urinary excretion of uric acid, xanthine, and oxypurinol were attributable to increases in the fractional clearances of uric acid, xanthine, and oxypurinol in addition to an increase in glomerular filtration rate. It is suggested that glucagon affects the renal common transport pathway of uric acid, xanthine, and oxypurinol by stimulating the release of a liver derived renal vasodilator.
authors.affiliation: Third Department of Internal Medicine, Hyogo College of Medicine, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Yamamoto
authors.forename: Y
authors.initials: Y
authors.lastname: Moriwaki
authors.forename: S
authors.initials: S
authors.lastname: Takahashi
authors.forename: Z
authors.initials: Z
authors.lastname: Tsutsumi
authors.forename: K
authors.initials: K
authors.lastname: Hiroishi
authors.forename: J
authors.initials: J
authors.lastname: Yamakita
authors.forename: T
authors.initials: T
authors.lastname: Nakano
authors.forename: K
authors.initials: K
authors.lastname: Higashino
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D002713:Chlorine / Q000097:blood; D003404:Creatinine / Q000378:metabolism; D000242:Cyclic AMP / Q000097:blood; D005934:Glucagon / Q000494:pharmacology*; D006801:Humans; D019271:Hypoxanthine / Q000097:blood / Q000652:urine; D007668:Kidney / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D009584:Nitrogen / Q000097:blood; D010117:Oxypurinol / Q000097:blood / Q000652:urine*; D010710:Phosphates / Q000097:blood; D011688:Purinones / Q000097:blood / Q000652:urine*; D012964:Sodium / Q000097:blood; D014527:Uric Acid / Q000097:blood / Q000652:urine; D019820:Xanthine; D014970:Xanthines / Q000097:blood / Q000652:urine
chemical_list: D001786:Blood Glucose; D010710:Phosphates; D011688:Purinones; D014970:Xanthines; D019820:Xanthine; D014527:Uric Acid; D019271:Hypoxanthine; D002713:Chlorine; D005934:Glucagon; D012964:Sodium; D003404:Creatinine; D000242:Cyclic AMP; D010117:Oxypurinol; D009584:Nitrogen