[Changes in lymphocytopoiesis in the thymus gland of the progeny of rats receiving progesterone].
Thymus cellular content was studied in newborns and 7- and 14-days pups whose mothers were treated with progesterone in different terms of pregnancy. Progesterone was administered daily in therapeutic (0.3 mg) and tenfold (3.0 mg) dozes. It was demonstrated that progesterone impact on the cellular content of the gland depends on the duration and terms of treatment. In short time introduction of progesterone in any dose changes of lymphopoiesis were observed either in newborns (in treatment from day 10 to day 12) or both in newborns and 7-days pups (in treatment from day 15 to day 17). In administration of progesterone through the entire pregnancy lymphopoiesis was changing in newborns and 7-days pups. No changes of poiesis were observed in 14-days pups in all cases. Long-term treatment with progesterone in tenfold doze caused extension of gestation up to 26-27 days fetal mortality and even some rats death. Significant alteration of cell content was found in thymus of newborns.
Churilova
N I
NI
Val'kovich
E I
EI
D000375:Aging / Q000187:drug effects; D000818:Animals; D000831:Animals, Newborn; D004305:Dose-Response Relationship, Drug; D005260:Female; D006411:Hematopoiesis, Extramedullary / Q000187:drug effects*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D011374:Progesterone / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D013601:T-Lymphocytes / Q000166:cytology / Q000187:drug effects*; D013950:Thymus Gland / Q000166:cytology / Q000187:drug effects*; D013997:Time Factors
D011374:Progesterone
Izmeneniia limfotsitopoéza v vilochkoĭ zheleze u potomstva krys, poluchavshikh progesteron.