Fractures and phenylketonuria.
Parent or self-reported history of fractures in a group of patients aged from 0.3 to 33.6 years on dietary treatment for phenylketonuria was studied by means of a questionnaire. Twenty-one of 85 patients had a history of fracture compared with 18/98 sibling controls. There was no significant difference in the lifetime risk of fracture between patients and controls (chi 2 = 1.43, df = 1, p = 0.23), but a significantly higher risk of fracture was reported over the age of 8 y (chi 2 = 5.11, df = 1, p = 0.024), with a relative risk of 2.6 (95% confidence interval 1.1.6.1). We suggest this may be related either to deterioration in dietary control in this age group or to a cumulative disease-related or diet-related reduction in bone mass.
Greeves
L G
LG
Royal Belfast Hospital for Sick Children, Department of Child Health, UK.
Carson
D J
DJ
Magee
A
A
Patterson
C C
CC
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D015519:Bone Density; D002648:Child; D002675:Child, Preschool; D004035:Diet Therapy / Q000009:adverse effects; D050723:Fractures, Bone / Q000150:complications* / Q000209:etiology; D006801:Humans; D007223:Infant; D010661:Phenylketonurias / Q000150:complications* / Q000628:therapy; D012307:Risk Factors