title: Atropine decreases drinking but not feeding and induces less hypothalamic acetylcholine release in diabetic rats.
abstract: Drinking, feeding and hypothalamic extracellular acetylcholine (ACh) release was measured before and after the administration of several doses of atropine sulfate in streptozotocin (STZ)-diabetic and normal rats. Drinking but not feeding was dose-relatedly decreased by i.p. or intrahypothalamic injections of atropine in STZ-diabetic rats. Hypothalamic ACh release, as measured by microdialysis, increased less (dose-related) in diabetic than normal rats following an i.p. administration of atropine. Ach basal levels were the same in both groups. These results are discussed in terms of a hyperactive hypothalamic cholinergic (muscarinic) system involved in the diabetic polydipsia.
authors.affiliation: Laboratory of Behavioral Physiology, School of Medicine, Los Andes University, Mérida, Venezuela.
authors.forename: E
authors.initials: E
authors.lastname: Murzi
authors.forename: P
authors.initials: P
authors.lastname: Rada
authors.forename: M
authors.initials: M
authors.lastname: Puig de Parada
authors.forename: M A
authors.initials: MA
authors.lastname: Parada
authors.forename: B
authors.initials: B
authors.lastname: Valecillos
authors.forename: C A
authors.initials: CA
authors.lastname: Tilac
authors.forename: L
authors.initials: L
authors.lastname: Hernandez
mesh_terms: D000109:Acetylcholine / Q000378:metabolism*; D000818:Animals; D001285:Atropine / Q000494:pharmacology*; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D004326:Drinking / Q000187:drug effects*; D004435:Eating / Q000187:drug effects*; D007031:Hypothalamus / Q000187:drug effects / Q000378:metabolism*; D007267:Injections; D007274:Injections, Intraperitoneal; D008297:Male; D017551:Microdialysis; D018727:Muscarinic Antagonists / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012016:Reference Values
chemical_list: D018727:Muscarinic Antagonists; D001285:Atropine; D000109:Acetylcholine