Detection of infection with human immunodeficiency virus type 1 before seroconversion: correlation with clinical symptoms and outcome.
Early (pre-seroconversion) infection with human immunodeficiency virus type 1 (HIV-1) was identified in 50 of 267 participants in the Multicenter AIDS Cohort Study. These 50 men had a positive EIA result, which detected IgM antibody (n = 35), p24 antigen, or serum HIV RNA (n = 15) at their last "seronegative" visit. At that visit, the mean CD4 lymphocyte number (890/mm3 vs. 1038/mm3) was significantly lower than in men who subsequently seroconverted but had no evidence of early infection. The decline in CD4 cells was slower and the duration of AIDS-free time longer in the 19 men who were symptomatic in comparison to the 31 asymptomatic men with early infection, but differences were not significant.
Phair
J P
JP
Department of Medicine, Northwestern University School of Medicine, and Howard Brown Health Center, Chicago, Illinois, USA.
Margolick
J B
JB
Jacobson
L P
LP
Phillips
J
J
Rinaldo
C
C
Kaslow
R
R
Chu
C
C
Giorgi
J V
JV
Henrard
D
D
D000163:Acquired Immunodeficiency Syndrome / Q000175:diagnosis*; D018791:CD4 Lymphocyte Count; D015483:HIV Antibodies / Q000097:blood; D006679:HIV Seropositivity / Q000276:immunology*; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D008297:Male; D012367:RNA, Viral / Q000032:analysis
D015483:HIV Antibodies; D012367:RNA, Viral