title: Lidocaine-induced CNS toxicity--a case report.
abstract: Lidocaine is the first local anesthetic of the amide type to be introduced to clinical practice. It is a versatile drug and in anesthesia, is the most commonly used local anesthetic because of its aptness of potency, rapid onset, moderate duration of action and topical activity. It is relatively safe and useful in many other clinical settings. Unfortunately, systemic intoxication and psychotic reaction associated with its use often occur because of its popularity and wider safety margin, for which guide in use is often ignored and overdose becomes commonplace. Moreover, due to its universality in use seldom reports have recently dealt with lidocaine, particularly regarding its toxic reaction. Here, we present a case of lidocaine intoxication occurring during circumcision for a reviewal of the problem. A healthy young male, weighing 65 kg, underwent circumcision for phimosis under penile block with 2% lidocaine which totaled 600 mg. Twenty minutes after injection the patient developed headache, tinnitus, visual and auditory disturbances. Muscle twitching over the mouth angles, trismus and rigidity of extremities were also noted. Later in the course he became restless, agitative, hallucinative, talkative, and verbose with repetitious words. The whole course of the disorder lasted about 5 h. It was believed that lidocaine-induced CNS intoxication, manifested by psychotic reaction broke out. Treatment with thiopental was not very impressive. Also, we took this opportunity to discuss and review the toxic reaction associated with the use of lidocaine, its risk factors, mechanism, treatment and prevention. The complicated associations of lidocaine-induced CNS toxic reaction with central control of behavior and the neurotransmitter systems (adrenergic, dopaminergic and serotonin) were also touched.
authors.affiliation: Department of Anesthesiology, Taipei Municipal Yang Ming Hospital, Taiwan, R.O.C.
authors.forename: Y Y
authors.initials: YY
authors.lastname: Chiang
authors.forename: K F
authors.initials: KF
authors.lastname: Tseng
authors.forename: Y W
authors.initials: YW
authors.lastname: Lih
authors.forename: T C
authors.initials: TC
authors.lastname: Tsai
authors.forename: C T
authors.initials: CT
authors.lastname: Liu
authors.forename: H K
authors.initials: HK
authors.lastname: Leung
mesh_terms: D000328:Adult; D000779:Anesthetics, Local / Q000009:adverse effects*; D001921:Brain / Q000187:drug effects*; D006801:Humans; D008012:Lidocaine / Q000009:adverse effects*; D008297:Male
chemical_list: D000779:Anesthetics, Local; D008012:Lidocaine