Cellular fibrous histiocytoma of the skin: evidence of a clonal process with different karyotype from dermatofibrosarcoma.
Recently, a distinct variant of cutaneous fibrous histiocytoma (FH) has been histologically characterized as a "cellular" subtype. This variant is often mistaken for sarcoma, including dermatofibrosarcoma protuberans. We report a case of cellular FH of the skin in which the cytogenetic analysis demonstrated a novel chromosome pattern, possibly allowing distinction from its histologic simulants.
Vanni
R
R
Istituto di Biologia Generale, University of Cagliari, Italy.
Marras
S
S
Faa
G
G
Licheri
S
S
Daniele
G M
GM
Fletcher
C D
CD
D000328:Adult; D002883:Chromosomes, Human, Pair 14; D002886:Chromosomes, Human, Pair 17; D002892:Chromosomes, Human, Pair 22; D018223:Dermatofibrosarcoma / Q000235:genetics* / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D018219:Histiocytoma, Benign Fibrous / Q000235:genetics* / Q000473:pathology; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D012878:Skin Neoplasms / Q000235:genetics* / Q000473:pathology