[Genetic aspects of endometriosis: features of the distribution of polymorphic gene frequencies].
In a group of patients with endometriosis and in a control group of healthy women, the polymorphism of the following systems were studied: ABO and RH blood-group systems; serum proteins haptoglobin (HP), transferrin (TF), vitamin D-transporting protein (GC), protease inhibitor (PI), and the third component of the complement (C3); serum enzymes-amylase of the loci 1 and 2 (AMY1 and AMY2), pseudocholinesterase (E2), and alkaline phosphatase (PP); erythrocytic enzymes-acid phosphatase (ACP1), phosphoglucomutase (PGM1), superoxide dismutase (SOD-A), esterase D (ESD), and glyoxalase (GLO1). Statistically significant differences between the groups compared were established for five genetic systems: ABO, E2, C3, TF, and PGM1. Among patient with endometriosis, the rare alleles of the locus ESD-ESD5 and ESD7-were found, along with ESD 5-5 homozygotes. Several genetic loci can be involved in the pathogenesis of endometriosis; their products can be specifically realized due to peculiarities of biochemical reactions in the organisms of people predisposed to this pathology.
Spitsyn
V A
VA
Andreeva
E N
EN
Adamian
L V
LV
Agapova
R K
RK
Sandoval'
Kh R
KhR
D000017:ABO Blood-Group System / Q000235:genetics; D000293:Adolescent; D000328:Adult; D000483:Alleles; D002091:Butyrylcholinesterase / Q000235:genetics; D016022:Case-Control Studies; D003176:Complement C3 / Q000235:genetics; D004715:Endometriosis / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D006580:Genetic Carrier Screening; D005819:Genetic Markers; D006801:Humans; D007519:Isoantigens / Q000235:genetics; D008875:Middle Aged; D010641:Phenotype; D010733:Phosphoglucomutase / Q000235:genetics; D011110:Polymorphism, Genetic; D014168:Transferrin / Q000235:genetics
D000017:ABO Blood-Group System; D003176:Complement C3; D005819:Genetic Markers; D007519:Isoantigens; D014168:Transferrin; D002091:Butyrylcholinesterase; D010733:Phosphoglucomutase
Geneticheskie aspekty éndometrioza: osobennosti raspredeleniia chastot polimorfnykh genov.