title: Protein-tyrosine phosphorylation in the Archaea.
abstract: Sulfolobus sulfataricus ATCC 35091, Haloferax volcanii, and Methanosarcina thermophila TM-1, representing the Euryarchaeota and Crenarchaeota subdomains of the Archaea, contain proteins which are phosphorylated on tyrosine. These data raise fundamental questions as to the origin and evolution of tyrosine phosphorylation, a protein modification that is of pivotal importance in the regulation of the physiology of eukaryotic cells.
authors.affiliation: Department of Biochemistry and Anaerobic Microbiology, Virginia Polytechnic Institute and State University, Blacksburg 24061, USA.
authors.forename: S C
authors.initials: SC
authors.lastname: Smith
authors.forename: P J
authors.initials: PJ
authors.lastname: Kennelly
authors.forename: M
authors.initials: M
authors.lastname: Potts
mesh_terms: D001105:Archaea / Q000378:metabolism*; D001426:Bacterial Proteins / Q000378:metabolism*; D017020:Methanosarcina / Q000378:metabolism*; D008970:Molecular Weight; D010750:Phosphoproteins / Q000378:metabolism*; D019000:Phosphotyrosine / Q000378:metabolism*; D016944:Sulfolobus / Q000378:metabolism*
chemical_list: D001426:Bacterial Proteins; D010750:Phosphoproteins; D019000:Phosphotyrosine