title: Long-term exercise patterns and immune function in healthy older women. A report of preliminary findings.
abstract: The purpose of this study was to examine the relationship between active versus inactive lifestyle and immunocompetence in older women. A sample of 46 independently dwelling, ambulatory and mentally alert women 60-98 years was examined, 25 who rated themselves as 'active' and 21 who rated themselves as 'inactive'. Lymphocyte subpopulations were analyzed by flow cytometry using selected monoclonal antibodies. The self-reported active subjects (also validated by their current unsolicited participation in a formal exercise class) demonstrated significantly higher percent change in CD25 mitogen stimulated lymphocytes (P = 0.0335) than those who reported themselves to be sedentary.
authors.affiliation: School of Nursing, Pennsylvania State University, University Park 16802, USA.
authors.forename: S H
authors.initials: SH
authors.lastname: Gueldner
authors.forename: L W
authors.initials: LW
authors.lastname: Poon
authors.forename: M
authors.initials: M
authors.lastname: La Via
authors.forename: G
authors.initials: G
authors.lastname: Virella
authors.forename: Y
authors.initials: Y
authors.lastname: Michel
authors.forename: M H
authors.initials: MH
authors.lastname: Bramlett
authors.forename: C A
authors.initials: CA
authors.lastname: Noble
authors.forename: E
authors.initials: E
authors.lastname: Paulling
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000276:immunology*; D000911:Antibodies, Monoclonal; D015703:Antigens, CD / Q000096:biosynthesis; D015444:Exercise; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D008019:Life Style; D008213:Lymphocyte Activation; D015375:Receptors, Interleukin-2 / Q000096:biosynthesis; D016176:T-Lymphocyte Subsets / Q000276:immunology*
chemical_list: D000911:Antibodies, Monoclonal; D015703:Antigens, CD; D015375:Receptors, Interleukin-2