A t(9;11) translocation in childhood acute mixed leukemia.
We present the case of a child with acute lymphoid leukemia (ALL) who was morphologically classified as FAB L1 (PAS and peroxidase were negative). Remission was achieved with an ALL-type protocol (GBTLI). Five months after the discontinuation of therapy, the patient presented mixed leukemia (CD10, CD19, CD13 and CD33 were positive) with t (9;11) (p21;q23) translocation. Unfortunately, as cytogenetic and immunophenotype studies were not performed at diagnosis, two possibilities could be considered for the relapse; secondary mixed leukemia with clonal chromosome changes, or mixed leukemia from the beginning.
Chauffaille
M L
ML
Department of Hematology, Escola Paulista de Medicina, São Paulo, Brazil.
Yamamoto
M
M
Odone Filho
V
V
Almeida
M T
MT
Maluf Júnior
P
P
Cristofani
L M
LM
Kerbauy
J
J
Raimondi
S C
SC
D002648:Child; D006801:Humans; D007621:Karyotyping; D015456:Leukemia, Biphenotypic, Acute / Q000235:genetics*; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics*; D014178:Translocation, Genetic