title: Methimazole-induced severe aplastic anemia: unsuccessful treatment with recombinant human granulocyte-monocyte colony-stimulating factor.
abstract: Aplastic anemia is a rare but severe complication of thionamide therapy. Although colony-stimulating factors have been used extensively in thionamide-induced agranulocytosis with good results, the same might not apply to aplastic anemia. We present a case of a patient with methimazole-induced aplastic anemia in which, as administration of recombinant human granulocyte-monocyte colony-stimulating factor for a week did not result in an increase in peripheral blood cell count, standard immunosuppressive treatment was needed to restore normal hematopoiesis. The clinical characteristics of this patient are compared with those of previous cases of thionamide-induced aplastic anemia, especially with the only other reported patient in which colony-stimulating factors were used.
authors.affiliation: Department of Endocrinology, Hospital Ramón y Cajal, Madrid, Spain.
authors.forename: H F
authors.initials: HF
authors.lastname: Escobar-Morreale
authors.forename: P
authors.initials: P
authors.lastname: Bravo
authors.forename: R
authors.initials: R
authors.lastname: García-Robles
authors.forename: J
authors.initials: J
authors.lastname: García-Laraña
authors.forename: H
authors.initials: H
authors.lastname: de la Calle
authors.forename: J M
authors.initials: JM
authors.lastname: Sancho
mesh_terms: D000741:Anemia, Aplastic / Q000139:chemically induced* / Q000188:drug therapy* / Q000473:pathology; D000961:Antilymphocyte Serum / Q000627:therapeutic use; D013956:Antithyroid Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001772:Blood Cell Count; D001853:Bone Marrow / Q000473:pathology; D016572:Cyclosporine / Q000627:therapeutic use; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000627:therapeutic use*; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008713:Methimazole / Q000009:adverse effects* / Q000627:therapeutic use; D008875:Middle Aged; D011994:Recombinant Proteins
chemical_list: D000961:Antilymphocyte Serum; D013956:Antithyroid Agents; D005938:Glucocorticoids; D006454:Hemoglobins; D007166:Immunosuppressive Agents; D011994:Recombinant Proteins; D008713:Methimazole; D016178:Granulocyte-Macrophage Colony-Stimulating Factor; D016572:Cyclosporine