Effectiveness of psychological and pharmacological treatments for obsessive-compulsive disorder: a quantitative review.
Quantitative review of the controlled treatment outcome literature for obsessive-compulsive disorder (OCD) showed that exposure with response prevention was highly effective in reducing OCD symptoms. Cognitive approaches were also found to be at least as effective as exposure procedures. It appears that both cognitive and exposure interventions involve some overlapping procedures and capitalize on similar mechanisms of change. Serotonergic medication, particularly clomipramine, also substantially reduced OCD symptoms. However, clomipramine may not be particularly superior to other serotonergic medication. The relationship between side effects and effect size in medication trials was explored.
Abramowitz
J S
JS
Department of Psychology, University of Memphis, Tennessee 38152, USA. jabramowitz@cc.memphis.edu
D001521:Behavior Therapy / Q000592:standards*; D002997:Clomipramine / Q000627:therapeutic use*; D015928:Cognitive Behavioral Therapy / Q000592:standards; D018849:Controlled Clinical Trials as Topic / Q000706:statistics & numerical data; D006801:Humans; D009771:Obsessive-Compulsive Disorder / Q000628:therapy*; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use*; D016896:Treatment Outcome
D002997:Clomipramine; D017367:Selective Serotonin Reuptake Inhibitors