title: Analysis of prognostic factors and patterns of failure in dogs with periodontal tumors treated with megavoltage irradiation.
abstract: OBJECTIVE
  To determine quality and duration of progression-free survival (PFS) time in dogs with periodontal tumors after definitive megavoltage irradiation and to analyze prognostic factors for PFS time and patterns of treatment failure.
  
  
  METHODS
  Prospective clinical trial.
  
  
  METHODS
  47 dogs with acanthomatous, fibromatous, or ossifying epulis.
  
  
  METHODS
  Dogs were treated with 48 Gy over 4 weeks on an alternate-day schedule of 4 Gy/fraction. Multivariate analysis was done by use of Cox's proportional hazards regression model to determine prognostic factors for PFS time.
  
  
  RESULTS
  The only independent prognostic factor for PFS time was tumor T stage. Pattern of local tumor recurrence (marginal vs infield regrowth) was independent of clinical stage, tumor location, and site. In 4% of the dogs, severe acute radiation reactions in the final week of treatment resulted in treatment discontinuation. In 6.4% of the dogs, chronic radiation reactions included bone necrosis.
  
  
  CONCLUSIONS
  Irradiation was a safe and effective treatment of small (T1 and T2 stage) periodontal tumors. The usefulness of the radiation protocol in this study is limited in dogs with large (T3) tumors, particularly those located in the caudal half of the oral cavity, because of poor results and high risk of acute radiation toxicoses.
authors.affiliation: Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis 95616-8745, USA.
authors.forename: A P
authors.initials: AP
authors.lastname: Théon
authors.forename: C
authors.initials: C
authors.lastname: Rodriguez
authors.forename: S
authors.initials: S
authors.lastname: Griffey
authors.forename: B R
authors.initials: BR
authors.lastname: Madewell
mesh_terms: D000818:Animals; D018572:Disease-Free Survival; D004283:Dog Diseases / Q000532:radiotherapy*; D004285:Dogs; D005260:Female; D005882:Gingival Diseases / Q000532:radiotherapy / Q000662:veterinary*; D008297:Male; D015999:Multivariate Analysis; D009364:Neoplasm Recurrence, Local / Q000662:veterinary; D009369:Neoplasms / Q000532:radiotherapy / Q000662:veterinary; D010510:Periodontal Diseases / Q000532:radiotherapy / Q000662:veterinary*; D016016:Proportional Hazards Models; D011446:Prospective Studies; D011882:Radiotherapy, High-Energy / Q000662:veterinary*; D012307:Risk Factors