[Improvement of expected and final height in girls with central precocious puberty treated with gonadotropin releasing hormone analogues].
BACKGROUND
To evaluate the effect of GnRH-analogue triptoreline on the predicted adult height and final height in central precocious puberty (CPP).


METHODS
The study included 14 girls with CPP treated for 1-6 years with triptoreline depot (75 micrograms/kg/28 days/i.m.; group 1). The criteria for diagnosis included the following: compelling evidence of rapid progression of puberty, with a bone age (BA) greater than 2 SD above the mean value for chronological age (CA) associated with poor initial predicted final height and growth speed greater than 2 SD above the mean value for age. In addition we obtained data from 6 untreated girls with advanced puberty and good predicted adult height followed during the same period of time (group II). 7 of 14 girls of group I and 5 of 6 girls of group II attained final height.


RESULTS
A decrease in growth speed and an increase and in CA/BA ratio were observed after three years of treatment (+4.9 +/- 0.7 SD to -1.45 +/- 2.63 SD and 0.62 +/- 0.14 to 0.74 +/- 0.09 respectively; P = 0.034; n = 6). The predicted adult height increased significantly after two years of treatment (153.1 +/- 4.49 to 156.94 +/- 5 cm; p = 0.041; n = 10) and was more evident after three years of treatment (153.84 +/- 5.77 to 160.7 +/- 7.5 cm; p = 0.03; n = 6). The final height of 7 girls of group I who attained it was similar to target height (161 +/- 3.1 vs. 159 +/- 1.3 cm; NS) and greater than initial predicted adult height (161 +/- 3.1 vs. 154 +/- 2.1 cm; p = 0.044) and than final height of the 5 girls of group II (161 +/- 3.1 vs. 154.28 +/- 6.1 cm).


CONCLUSIONS
Triptorelin depot improves predicted adult height and final height of girls with early central puberty may be over their target height.
Gómez
F
F
Servicio de Pediatría, Hospital General de Elx, Alicante.
Picó
A M
AM
Vargas
F
F
Mauri
M
M
D001827:Body Height; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives*; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology; D011379:Prognosis; D011629:Puberty, Precocious / Q000188:drug therapy* / Q000503:physiopathology; D013997:Time Factors; D017329:Triptorelin Pamoate / Q000627:therapeutic use*
D017329:Triptorelin Pamoate; D007987:Gonadotropin-Releasing Hormone
Mejoría del pronóstico de talla y de la talla final en niñas con pubertad precoz central tratadas con análogos de la hormona liberadora de gonadotropinas.