Pharmacological prophylaxis of bleeding in surgical patients treated with aspirin.
A Medline search and subsequent meta-analysis shows that pre-operative aspirin increases blood loss and transfusion requirements in patients undergoing coronary artery bypass grafting. Both aprotinin and desmopressin are effective in counteracting this. There are almost no data on the effects of bleeding of aspirin, aprotinin and desmopressin in other procedures.
Flordal
P A
PA
Department of Surgery, Danderyd Hospital, Sweden.
D007611:Aprotinin / Q000627:therapeutic use*; D001241:Aspirin / Q000009:adverse effects*; D016063:Blood Loss, Surgical / Q000517:prevention & control*; D003894:Deamino Arginine Vasopressin / Q000627:therapeutic use*; D006490:Hemostatics / Q000627:therapeutic use*; D006801:Humans; D010975:Platelet Aggregation Inhibitors / Q000009:adverse effects*
D006490:Hemostatics; D010975:Platelet Aggregation Inhibitors; D007611:Aprotinin; D003894:Deamino Arginine Vasopressin; D001241:Aspirin