title: [Antithrombotic therapy in patients with mechanical valve prostheses].
abstract: Mechanical valvular prostheses have the advantage of longevity but carry a risk of thrombosis which is itself dependent on many haemodynamic, haemostatic and parietal factors. Antithrombotic therapy in patients with mechanical valvular prostheses is based on vitamin-K antagonists, the optimal dosage of which should reflect the type and location of the prosthesis and the underlying pathology. The patient with a mechanical valvular prosthesis treated by oral anticoagulation must be fully informed and regularly followed up. Special situations: extracardiac surgery, dental extraction, gastrointestinal endoscopy, require specific, well established management.
authors.affiliation: Service de cardiologie, Hôpital cardiologique du Haut-Lévêque, Pessac.
authors.forename: R
authors.initials: R
authors.lastname: Roudaut
authors.forename: M F
authors.initials: MF
authors.lastname: Lorient-Roudaut
mesh_terms: D000284:Administration, Oral; D000925:Anticoagulants / Q000494:pharmacology / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D006350:Heart Valve Prosthesis; D006493:Heparin / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D010353:Patient Education as Topic; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*; D011247:Pregnancy; D013923:Thromboembolism / Q000517:prevention & control*; D016896:Treatment Outcome; D014812:Vitamin K / Q000037:antagonists & inhibitors*
chemical_list: D000925:Anticoagulants; D010975:Platelet Aggregation Inhibitors; D014812:Vitamin K; D006493:Heparin
vernacular_title: Traitement antithrombotique chez le porteur de prothèse valvulaire mécanique.