Cardiopulmonary responses to intravenous infusion of soluble and relatively insoluble gases.
BACKGROUND
Carbon dioxide is the current gas of choice for pneumoperitoneum, but hemodynamic and acid-base effects secondary to its systemic absorption have been reported. Various studies have suggested inert gases as alternatives.


METHODS
We studied the cardiopulmonary responses to intravenous infusion of carbon dioxide, nitrous oxide, argon, helium, and nitrogen in anesthetized swine. The gas was infused into the femoral vein at a rate of 0.1 ml . kg-1 . min-1 for 30 min. The changes in end-tidal CO2, mean arterial pressure, hemodynamics, and arterial blood gases were compared to baseline values.


RESULTS
No animals died during infusion of the soluble gases (CO2 and N2O). Three of the five pigs infused with nitrogen died suddenly at 20 and 30 min of infusion. The animals in the insoluble gas groups (Ar, He, N2) experienced clinical pulmonary gas embolism and severe acidemia, hypercapnea and tachycardia.


CONCLUSIONS
Venous gas embolism is poorly tolerated when the gas is relatively insoluble. Insoluble gases should not be used for pneumoperitoneum when there is any risk of venous gas embolism.
Roberts
M W
MW
Department of Surgery, University of California Davis Medical Center, 4301 X Street, Room 2310, Sacramento, CA 95817, USA.
Mathiesen
K A
KA
Ho
H S
HS
Wolfe
B M
BM
D000818:Animals; D001128:Argon / Q000008:administration & dosage / Q000494:pharmacology; D002245:Carbon Dioxide / Q000008:administration & dosage / Q000494:pharmacology; D004618:Embolism, Air / Q000209:etiology*; D005260:Female; D005740:Gases / Q000008:administration & dosage / Q000494:pharmacology*; D006371:Helium / Q000008:administration & dosage / Q000494:pharmacology; D006439:Hemodynamics / Q000187:drug effects; D007262:Infusions, Intravenous; D008297:Male; D009584:Nitrogen / Q000008:administration & dosage / Q000494:pharmacology; D009609:Nitrous Oxide / Q000008:administration & dosage / Q000494:pharmacology; D011028:Pneumoperitoneum, Artificial / Q000009:adverse effects; D011655:Pulmonary Embolism / Q000209:etiology*; D012307:Risk Factors; D013552:Swine
D005740:Gases; D002245:Carbon Dioxide; D006371:Helium; D001128:Argon; D009609:Nitrous Oxide; D009584:Nitrogen