title: Increased serum and low-density-lipoprotein antioxidant potential after antioxidant supplementation in endurance athletes.
abstract: We studied the effect of antioxidant supplementation on acute exercise-induced lipid peroxidation and antioxidant potential measured in serum and low-density-lipoprotein (LDL) samples. Eight endurance athletes repeated a 31-km running exercise twice with an interval of 4 wk. During the 4 wk before the runs, the subjects took in a single-blind randomized order either a combination of antioxidant supplements (the antioxidant trial; 294 mg vitamin E, 1000 mg vitamin C, and 60 mg ubiquinone daily) or placebo (the placebo trial). Venous blood samples were taken before and immediately after the 31-km run in both trials. Antioxidant supplementation raised the LDL antioxidant potential (TRAP) (40% and 30%, P = 0.0031), serum TRAP (9% and 10%, P = 0.0037), and serum alpha-tocopherol concentration (by 59% and 66%, P = 0.0004) in both pre- and postexercise samples, respectively. The supplementation did not, however, affect the concentration of LDL diene conjugation (DC) or of serum DC. Physical exercise increased serum DC (by 18% and 10%, P = 0.0004) but not LDL-DC, and the quantity of the increment of serum DC was not affected by antioxidant intervention. The major cause for the increased LDL-TRAP and serum TRAP after antioxidant supplementation is apparently the elevation of the serum alpha-tocopherol concentration.
authors.affiliation: Paavo Nurmi Center, Sports Medical Research Unit, University of Turku, Finland.
authors.forename: T J
authors.initials: TJ
authors.lastname: Vasankari
authors.forename: U M
authors.initials: UM
authors.lastname: Kujala
authors.forename: T M
authors.initials: TM
authors.lastname: Vasankari
authors.forename: T
authors.initials: T
authors.lastname: Vuorimaa
authors.forename: M
authors.initials: M
authors.lastname: Ahotupa
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000378:metabolism* / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000494:pharmacology; D015444:Exercise / Q000502:physiology; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects* / Q000502:physiology; D008077:Lipoproteins, LDL / Q000097:blood*; D008297:Male; D010807:Physical Endurance / Q000502:physiology*; D012420:Running / Q000502:physiology; D016037:Single-Blind Method; D014451:Ubiquinone / Q000494:pharmacology; D014810:Vitamin E / Q000097:blood / Q000494:pharmacology
chemical_list: D000975:Antioxidants; D008077:Lipoproteins, LDL; D014451:Ubiquinone; D014810:Vitamin E; D001205:Ascorbic Acid