title: [Neuroendocrine carcinoma of the ampullar region with oat-cell histological features and adenocarcinoma].
abstract: We report a case of primary duodenal carcinoma showing neuroendocrine and glandular differentiation, in a 65-years-old male. Both components were closely related and transition between them was observed. The neuroendocrine component was composed of an undifferentiated "oat-cell" type, with positive immunostaining for neuroendocrine and epithelial markers. Ultrastructural findings confirmed this double differentiation, with dense cytoplasmatic granules of neurosecretory type. The neuroendocrine component showed greater aggressiveness with lymph node metastasis.
authors.affiliation: Servicio de Anatomía Patológica, Hospital Covadonga, Universidad de Oviedo.
authors.forename: M F
authors.initials: MF
authors.lastname: Fresno
authors.forename: P
authors.initials: P
authors.lastname: Floriano
authors.forename: J M
authors.initials: JM
authors.lastname: Díaz Iglesias
authors.forename: P
authors.initials: P
authors.lastname: Ablanedo
authors.forename: M J
authors.initials: MJ
authors.lastname: Pérez del Río
authors.forename: L
authors.initials: L
authors.lastname: Barneo
authors.forename: A
authors.initials: A
authors.lastname: Herrero
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D000368:Aged; D014670:Ampulla of Vater / Q000473:pathology / Q000601:surgery; D001706:Biopsy; D018288:Carcinoma, Small Cell / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D003138:Common Bile Duct Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D004379:Duodenal Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery
vernacular_title: Carcinoma neuroendocrino de la región ampular con rasgos histológicos de "oat-cell" y adenocarcinoma.