The poly(C) region affects progression of encephalomyocarditis virus infection in Langerhans' islets but not in the myocardium.
The diabetogenic variant PV2 of encephalomyocarditis virus was cloned, and three recombinants differing in their 5' poly(C) tracts were analyzed. It is shown that the poly(C) region is not essential for infectivity in mice but does influence the virus load and degree of pathological lesions within the Langerhans' islets but not in the myocardium.
Zimmermann
A
A
Institut für Virologie der Universität zu Köln, Cologne, Germany.
Botta
A
A
Arnold
G
G
Eggers
H J
HJ
Nelsen-Salz
B
B
D000818:Animals; D001483:Base Sequence; D018188:Cardiovirus Infections / Q000473:pathology*; D004686:Encephalomyocarditis virus / Q000472:pathogenicity*; D007515:Islets of Langerhans / Q000473:pathology*; D051379:Mice; D008969:Molecular Sequence Data; D009206:Myocardium / Q000473:pathology*; D011066:Poly C / Q000633:toxicity*
D011066:Poly C