[Combined hereditary deficiency in factors VII and X revealed by a prolonged partial thromboplastin time].
BACKGROUND
Congenital factors VII and X deficiency is rare. Association of both deficiencies is exceptional.


METHODS
A 3 year-old boy, born to consanguinous Moroccan parents, had a prolonged partial thromboplastin time discovered fortuitously. This finding led to the diagnosis of combined factors VII and X deficiency. His siblings had the same deficiencies.


CONCLUSIONS
Profound deficiencies in factors VII and X are inherited following an autosomal-recessive mode. These deficiencies may be asymptomatic, only discovered by prolonged partial thromboplastin time. They may also be revealed by intracranial bleeding and other severe hemorrhages. Treatment consists of administration of factor VII or PPSB.
Boxus
G
G
Service de pédiatrie, clinique Notre-Dame de Grâce, Gosselies, Belgique.
Slacmeulder
M
M
Ninane
J
J
D001779:Blood Coagulation Factors / Q000627:therapeutic use; D002675:Child, Preschool; D005167:Factor VII / Q000627:therapeutic use; D005168:Factor VII Deficiency / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics*; D005171:Factor X Deficiency / Q000150:complications* / Q000175:diagnosis / Q000235:genetics*; D006801:Humans; D008297:Male; D010314:Partial Thromboplastin Time
D001779:Blood Coagulation Factors; C025667:prothrombin complex concentrates; D005167:Factor VII
Déficit héréditaire combiné en facteurs VII et X révélé par un allongement du temps de Quick.