A comparison of mucosal inflammatory responses to Giardia muris in resistant B10 and susceptible BALB/c mice.
In the first three weeks of primary Giardia muris infections B10 mice clear infection more rapidly than BALB/c mice. There is evidence that interferon-gamma contributes to the relative resistance of B10 mice. The nature of the functional contribution of interferon-gamma is unclear and does not relate to the secretory or serum antibody response. Mucosal inflammatory events in these strains have been studied. Apart from a small rise in both strains of goblet cell and mucosal mast cell numbers, associated with release of mast cell protease-1 in serum, no inflammatory infiltrate was observed at the time trophozoites were cleared from the intestinal lumen. Inhibition of mast cell products (5-hydroxytryptamine and histamine) by cyproheptadine enhanced the intensity of infection in both strains. The relative resistance of B10 mice could not be explained in terms of the mucosal inflammatory response.
Venkatesan
P
P
Department of Life Science, University of Nottingham, UK.
Finch
R G
RG
Wakelin
D
D
D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D053818:Chymases; D005260:Female; D005872:Giardia / Q000276:immunology*; D005873:Giardiasis / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D018928:Immunity, Mucosal; D007249:Inflammation / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D007413:Intestinal Mucosa / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D008407:Mast Cells / Q000276:immunology / Q000473:pathology; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D009569:Nitric Oxide / Q000096:biosynthesis; D012697:Serine Endopeptidases / Q000097:blood; D013045:Species Specificity
D000975:Antioxidants; D009569:Nitric Oxide; D012697:Serine Endopeptidases; D053818:Chymases; C509230:Mcpt1 protein, mouse