Gastroprotective effect of malotilate in indomethacin- and ethanol-induced gastric mucosal damage.
Malotilate as a synthetic substance shares comparable hepatoprotective properties with various flavonoids. The gastroprotective effect of some flavonoids prompted us to ascertain the similar effectiveness of malotilate. The possible gastroprotectivity was examined in gastric mucosal damage in rats induced by indomethacin (20 mg.kg-1) or ethanol (96%). Oral pretreatment with malotilate (25, 50, 100, 200 and 400 mg.kg-1) reduced the extent of lesions induced by both indomethacin and ethanol. Histological analyses also revealed a mitigating effect on the severity of gastric mucosal lesions. Similar results were obtained in the group of rats pretreated with 5 mg.kg-1 indomethacin followed by oral administration of 96% ethanol. This finding suggests that the effect of malotilate on rat gastric mucosa is independent of endogenous prostaglandin production.
Mirossay
L
L
Department of Pharmacology, Faculty of Medicine, Safárik University, Kosice, Slovak Republic.
Mojzis
J
J
Sallingová
Z
Z
Bodnar
J
J
Benický
M
M
Böör
A
A
Kohút
A
A
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D000431:Ethanol; D005753:Gastric Mucosa / Q000473:pathology; D007213:Indomethacin; D008297:Male; D008314:Malonates / Q000494:pharmacology*; D011453:Prostaglandins / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013276:Stomach Ulcer / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D013392:Sucralfate / Q000494:pharmacology
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000897:Anti-Ulcer Agents; D008314:Malonates; D011453:Prostaglandins; D000431:Ethanol; D013392:Sucralfate; C024808:diisopropyl 1,3-dithiol-2-ylidenemalonate; D007213:Indomethacin