No evidence of linkage for cleft lip with or without cleft palate to a marker near the transforming growth factor alpha locus in two populations.
Nonsyndromic cleft lip with or without cleft palate is a common birth defect, affecting approximately 1 in 1,000 Caucasian newborns. Thirty-five multiplex families from the mid-Atlantic region of the United States and 22 families from central Mexico with a nonsyndromic form of cleft lip with or without cleft palate were selected for a linkage analysis. A tetranucleotide repeat marker (D2S443) located on the same yeast artificial chromosome as the transforming growth factor alpha locus was tested for linkage to a putative susceptibility Mendelian locus under varying levels of pentrance. No evidence for linkage between D2S443 and a susceptibility locus for cleft lip with or without cleft palate was found. Insight is given to explain this outcome in spite of the statistically significant associations found by other investigators.
Wyszynski
D F
DF
Department of Epidemiology, School of Hygiene and Public Health, Johns Hopkins University, Baltimore, Md. 21205, USA.
Maestri
N
N
Lewanda
A F
AF
McIntosh
I
I
Smith
E A
EA
García-Delgado
C
C
Vinageras-Guarneros
E
E
Wulfsberg
E
E
Beaty
T H
TH
D002874:Chromosome Mapping; D002971:Cleft Lip / Q000235:genetics*; D002972:Cleft Palate / Q000235:genetics*; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D018895:Microsatellite Repeats; D016211:Transforming Growth Factor alpha / Q000235:genetics*
D005819:Genetic Markers; D016211:Transforming Growth Factor alpha