title: Genotoxicity of nitro musks in the micronucleus test with human lymphocytes in vitro and the human hepatoma cell line Hep G2.
abstract: The nitro musk compounds musk xylene (1-tert.-butyl-3,5-dimethyl-2,4,6-trinitrobenzene), musk ketone (4-tert.-butyl-3,5-dinitro-2,6-dimethylacetophenone), musk ambrette (1-tert.-butyl-4-methyl-6-methoxy-3,5-dinitrobenzene), musk moskene (1,1,3,3,5-pentamethyl-4,6-dinitroindane) and musk tibetene (1-tert.-butyl-3,4,5-trimethyl-2,6-dinitrobenzene) were tested for their genotoxic activity in the micronucleus test (MN) with human lymphocytes in vitro and the human hepatoma cell line Hep G2. Compound concentrations were employed up to cytotoxic doses. Musk xylene, musk ketone, musk ambrette, musk moskene and musk tibetene revealed no genotoxicity in the micronucleus test with human lymphocytes and with the human hepatoma cell line Hep G2.
authors.affiliation: Medical Institute for General Hygiene and Environmental Health, University of Göttingen, FRG.
authors.forename: S
authors.initials: S
authors.lastname: Kevekordes
authors.forename: A
authors.initials: A
authors.lastname: Zaulig
authors.forename: H
authors.initials: H
authors.lastname: Dunkelberg
mesh_terms: D000328:Adult; D006528:Carcinoma, Hepatocellular; D002478:Cells, Cultured; D016009:Chi-Square Distribution; D004136:Dinitrobenzenes / Q000633:toxicity; D006801:Humans; D007189:Indans / Q000633:toxicity; D008113:Liver Neoplasms; D008214:Lymphocytes / Q000166:cytology / Q000187:drug effects*; D015162:Micronucleus Tests; D009153:Mutagens / Q000633:toxicity*; D010476:Perfume / Q000633:toxicity*; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured; D014874:Water Pollutants, Chemical / Q000633:toxicity*; D014992:Xylenes / Q000633:toxicity
chemical_list: D004136:Dinitrobenzenes; D007189:Indans; D009153:Mutagens; D010476:Perfume; D014874:Water Pollutants, Chemical; D014992:Xylenes; C042842:musk tibetine; C042841:moskene; C031447:musk xylene; C031448:musk ketone; C020422:musk ambrette (artificial)