Polymorphism of the tumour necrosis factor beta gene in multiple sclerosis and rheumatoid arthritis.
We evaluated the TNF-beta gene polymorphism in two HLA-associated autoimmune diseases, multiple sclerosis (MS) and rheumatoid arthritis (RA). The TNF-beta allele and genotype frequencies were not significantly different in the patient populations, compared to controls. An increased frequency of the TNF-beta*2 allele was observed in HLA-DR2+ vs. HLA-DR2- MS patients. No such association was seen in HLA-DR4+ RA patients.
Vandevyver
C
C
Department of Immunology/Biotechnology, Dr L. Willems-Institut, Diepenbeek, Belgium.
Raus
P
P
Stinissen
P
P
Philippaerts
L
L
Cassiman
J J
JJ
Raus
J
J
D000483:Alleles; D001172:Arthritis, Rheumatoid / Q000453:epidemiology / Q000235:genetics*; D001327:Autoimmune Diseases / Q000453:epidemiology / Q000235:genetics*; D004198:Disease Susceptibility; D005838:Genotype; D015802:HLA-DR2 Antigen / Q000235:genetics; D015804:HLA-DR4 Antigen / Q000235:genetics; D006801:Humans; D008233:Lymphotoxin-alpha / Q000235:genetics*; D009103:Multiple Sclerosis / Q000453:epidemiology / Q000235:genetics*; D011110:Polymorphism, Genetic; D012306:Risk
D015802:HLA-DR2 Antigen; D015804:HLA-DR4 Antigen; D008233:Lymphotoxin-alpha