Relationship between plasma endothelin-1 levels and myocardial ischemia induced by exercise testing.
At peak exercise, plasma endothelin-1 concentration increases in patients with effort angina as well as thallium-201 radionuclide perfusion defects; the opposite occurs in patients with normal scans and in healthy volunteers. It is concluded that exercise-induced ischemia correlates with enhanced endothelin-1 production.
Fontana
F
F
Dipartimento di Medicina Interna, Universita degli Studi di Bologna, Italy.
Tarsi
G
G
Boschi
S
S
De Iasio
R
R
Monetti
N
N
Bugiardini
R
R
D000787:Angina Pectoris / Q000097:blood* / Q000175:diagnosis / Q000000981:diagnostic imaging; D016022:Case-Control Studies; D019332:Endothelin-1 / Q000097:blood*; D005080:Exercise Test; D005260:Female; D006321:Heart / Q000000981:diagnostic imaging; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000097:blood* / Q000175:diagnosis / Q000000981:diagnostic imaging; D011877:Radionuclide Imaging; D013794:Thallium Radioisotopes
D019332:Endothelin-1; D013794:Thallium Radioisotopes