Atypical MRI features of Wilson's disease: high signal in globus pallidus on T1-weighted images.
Most reports of MRI in Wilson's disease have been of abnormal low-signal lesions on T1-weighted images and high signal intensity on T2-weighted images. In contrast, we report three patients who had high-signal lesions in the globus pallidus on T1-weighted images, a finding seen in patients with portal-systemic encephalopathy. The possible causes include the paramagnetic effect of copper or iron and accumulation of Alzheimer type II glial cells.
Mochizuki
H
H
Third Department of Internal Medicine, National Defense Medical College, Saitama, Japan.
Kamakura
K
K
Masaki
T
T
Okano
M
M
Nagata
N
N
Inui
A
A
Fujisawa
T
T
Kaji
T
T
D000328:Adult; D000544:Alzheimer Disease / Q000175:diagnosis; D003300:Copper / Q000378:metabolism; D003937:Diagnosis, Differential; D005260:Female; D005917:Globus Pallidus / Q000473:pathology*; D006501:Hepatic Encephalopathy / Q000175:diagnosis*; D006527:Hepatolenticular Degeneration / Q000175:diagnosis*; D006801:Humans; D007501:Iron / Q000378:metabolism; D008279:Magnetic Resonance Imaging; D008297:Male; D008636:Mesencephalon / Q000473:pathology; D009457:Neuroglia / Q000473:pathology; D011699:Putamen / Q000473:pathology
D003300:Copper; D007501:Iron