Euglena gracilis as a supplementary test organism for detecting biologically active compounds.
The mutagenic activity of more than 120 antimicrobial agents and protective components was investigated. Only Kathon showed a consistent increase in revertant counts in the Ames test on Salmonella typhimurium. The hereditary bleaching test on Euglena gracilis used for detecting extranuclear mutations, showed positive results for Kathon, triethanolamine and diamine silver tetraborate.
Macor
M
M
Department of Molecular Biology, Faculty of Science, Comenius University, Bratislava, Slovakia.
Beno
J
J
Grones
J
J
Siekel
P
P
Novotný
J
J
D000818:Animals; D001681:Biological Assay / Q000379:methods; D001881:Borates / Q000009:adverse effects* / Q000494:pharmacology; D003358:Cosmetics / Q000009:adverse effects* / Q000494:pharmacology; D003604:Czechoslovakia; D004983:Ethanolamines / Q000009:adverse effects* / Q000494:pharmacology; D005056:Euglena gracilis / Q000187:drug effects* / Q000235:genetics; D006203:Hair Preparations / Q000009:adverse effects* / Q000494:pharmacology; D016296:Mutagenesis; D009152:Mutagenicity Tests / Q000379:methods*; D012486:Salmonella typhimurium / Q000187:drug effects; D013844:Thiazoles / Q000009:adverse effects* / Q000494:pharmacology
D001881:Borates; D003358:Cosmetics; D004983:Ethanolamines; D006203:Hair Preparations; D013844:Thiazoles; C021755:tetraborate; C037057:Kathon 886; C009546:triethanolamine