The effect of oral quercetin on UVB-induced tumor growth and local immunosuppression in SKH-1.
The effects of quercetin (4%) on UVB-induced carcinogenesis and immunosuppression were studied in hairless SKH-1 mice exposed daily to suberythemal UVB for 12/13 and 16/17 weeks. Macroscopic and microscopic examinations showed that quercetin did not affect the onset and growth of UVB-induced non-melanoma skin tumors. Quercetin prevented the UV-induced suppression of the contact hypersensitivity (CHS) and the reduction of the percentage of CD8-positive cells in spleen and lymph nodes. Other immunological parameters were not affected. Thus, the results indicate that oral intake of a high dose of quercetin does not prevent UVB-induced carcinogenesis, although it restores the skin-associated CHS response.
Steerenberg
P A
PA
National Institute of Public Health and the Environment, Laboratory for Pathology and Immunobiology, Bilthoven, The Netherlands.
Garssen
J
J
Dortant
P M
PM
van der Vliet
H
H
Geerse
E
E
Verlaan
A P
AP
Goettsch
W G
WG
Sontag
Y
Y
Bueno-de-Mesquita
H B
HB
Van Loveren
H
H
D000284:Administration, Oral; D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D003877:Dermatitis, Contact; D051379:Mice; D008815:Mice, Inbred Strains; D009381:Neoplasms, Radiation-Induced / Q000473:pathology*; D011794:Quercetin / Q000008:administration & dosage / Q000494:pharmacology*; D012878:Skin Neoplasms / Q000276:immunology / Q000473:pathology*; D014466:Ultraviolet Rays
D011794:Quercetin