Inhibition and attention deficit hyperactivity disorder.
This paper updates the author's earlier hypothesis that Attention Deficit Hyperactivity Disorder (ADHD) reflects underactivity in Gray's Behavioral Inhibition System. Five areas of research are reviewed: (1) studies using the stop-signal task, (2) studies of errors of commission, (3) a study of inhibition indexed by eye movements, (4) a neuroimaging study of the corpus callosum, and (5) a study on the prediction of response to methylphenidate. Data from the many different dependent variables in these studies are interpreted as supporting disinhibition as a core deficit in ADHD.
Quay
H C
HC
University of Miami, Coral Gables, Florida 33124, USA.
D001289:Attention Deficit Disorder with Hyperactivity / Q000175:diagnosis* / Q000188:drug therapy / Q000523:psychology; D001931:Brain Mapping; D000697:Central Nervous System Stimulants / Q000009:adverse effects / Q000627:therapeutic use; D002648:Child; D006801:Humans; D007266:Inhibition, Psychological; D008774:Methylphenidate / Q000627:therapeutic use
D000697:Central Nervous System Stimulants; D008774:Methylphenidate