title: Review of the fetal radiation doses received from 59Fe kinetic studies at Vanderbilt University in the 1940's.
abstract: Fetal radiation dose estimates were calculated for women who received oral administrations of 59Fe at Vanderbilt University in the 1940's. A similar dosimetry analysis was performed by Dyer and Brill in 1972; the availability of recently developed physical models of the pregnant female at different stages of gestation and of a new kinetic model for iron metabolism afforded an opportunity to re-evaluate these doses. Radiation dose estimates for the fetus (and fetal liver in three cases) were calculated for a number of oral and intravenous studies using these new models and the available data about the original experiments. The total fetal doses do not appear to have exceeded a few hundred microgray (a few tens of millirad) for the majority of the study subjects. Considerable uncertainty exists, however, in the amount of activity administered to these subjects.
authors.affiliation: Oak Ridge Institute for Science and Education, TN 37831-0117, USA.
authors.forename: M G
authors.initials: MG
authors.lastname: Stabin
authors.forename: J B
authors.initials: JB
authors.lastname: Stubbs
authors.forename: J R
authors.initials: JR
authors.lastname: Russell
mesh_terms: D000284:Administration, Oral; D005314:Embryonic and Fetal Development; D005260:Female; D005865:Gestational Age; D006801:Humans; D007504:Iron Radioisotopes / Q000008:administration & dosage / Q000493:pharmacokinetics*; D007700:Kinetics; D008099:Liver / Q000196:embryology / Q000378:metabolism; D008954:Models, Biological; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D013714:Tennessee; D014018:Tissue Distribution; D014495:Universities
chemical_list: D007504:Iron Radioisotopes