[Early endotoxin tolerance--a preventive concept against infection].
After induction of early-phase endotoxin tolerance in a porcine endotoxin shock model over a period of 3-4 days a highly significant survival-time extension (p < or = 0.0001) was achieved. The protective effect of the unspecific tolerant state led to a significant enhancement of cardiorespiratory parameters during the continuous endotoxin challenge. However, the level of tolerance is relative and can be overcome by increasing the endotoxin challenge dose.
Staubach
K H
KH
Klinik für Chirurgie, Medizinische Universität zu Lübeck.
Jonas
S
S
Kooistra
A
A
Bruch
H P
HP
D000818:Animals; D001427:Bacterial Toxins / Q000276:immunology*; D019446:Endotoxemia / Q000276:immunology*; D004731:Endotoxins / Q000276:immunology*; D007108:Immune Tolerance / Q000276:immunology; D008070:Lipopolysaccharides / Q000276:immunology*; D012475:Salmonella / Q000276:immunology*; D012772:Shock, Septic / Q000276:immunology*; D013552:Swine
D001427:Bacterial Toxins; D004731:Endotoxins; D008070:Lipopolysaccharides; C027952:salmonella toxin
Die frühe Endotoxintoleranz--ein prophylaktisches Konzept gegen Sepsis.