Uveitis: is ocular toxoplasmosis only a clinical diagnosis?
Between 1981 and 1994, the detection of specific antibodies against Toxoplasma gondii was performed simultaneously in serum and aqueous humor from 90 patients, and the Witmer-Desmonts coefficient measuring the relative concentration of antibodies produced locally was calculated to confirm the clinical diagnosis of ocular toxoplasmosis. Thirty-seven results were positive (41.1%), 12 uncertain (13.3%) and 41 negative (45.6%). These results are compared with the data obtained by the polymerase chain reaction for the genomic detection of an infectious agent in the aqueous humor that have recently been published.
Bornand
J E
JE
Laboratoire Central de Virologie, Hôpital Cantonal Universitaire, Genève, Suisse.
de Gottrau
P
P
D000818:Animals; D000913:Antibodies, Protozoan / Q000032:analysis*; D001082:Aqueous Humor / Q000382:microbiology*; D002825:Chorioretinitis / Q000175:diagnosis / Q000469:parasitology; D003937:Diagnosis, Differential; D019084:Fluorescent Antibody Technique, Indirect; D006801:Humans; D016133:Polymerase Chain Reaction; D016053:RNA, Protozoan / Q000032:analysis; D012189:Retrospective Studies; D014122:Toxoplasma / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*; D014126:Toxoplasmosis, Ocular / Q000175:diagnosis* / Q000209:etiology; D014605:Uveitis / Q000175:diagnosis* / Q000469:parasitology
D000913:Antibodies, Protozoan; D016053:RNA, Protozoan