Chromosomal localization of the human urothelial "tetraspan" gene, UPK1B, to 3q13.3-q21 and detection of a TaqI polymorphism.
The TI1/UPK1b gene codes for a protein of the "tetraspan" family and is expressed as a differentiation product of the mammalian urothelium. A partial genomic clone of the human homologue of the TI1/UPK1b gene was isolated and used as probe to localize the human gene to chromosome 3q13.3-q21 by in situ hybridization. Using the same probe, a TaqI restriction fragment length polymorphism, with 29% heterozygosity, was identified by Southern analysis.
Finch
J L
JL
Department of Surgery, The University of Adelaide, Woodville, South Australia, 5011, Australia.
Webb
G C
GC
Evdokiou
A
A
Cowled
P A
PA
D002874:Chromosome Mapping; D002893:Chromosomes, Human, Pair 3; D003001:Cloning, Molecular; D006801:Humans; D012150:Polymorphism, Restriction Fragment Length; D011506:Proteins / Q000235:genetics*; D019459:Urothelium / Q000378:metabolism*
D011506:Proteins