title: [The use of intraoperative topical bupivacaine in the control of postoperative pain following laparoscopic cholecystectomy].
abstract: Taking the starting point of a trial conducted on female patients who had undergone laparoscopic gynaecologic operations, which shows a good control of the postoperative pain through intraperitoneal infusion of local anaesthetic during the operation, the authors have proposed to reproduce the study on patients undergoing a laparoscopic cholecystectomy. The trial was conducted on two groups, a 50 patients each, undergoing an intraperitoneal infusion of local anaesthetic (bupivacaine) and placebo (physiologic solution) respectively. The results regarding the rate of patients who had felt postoperative pain (88% in the first group, 96% in the second group) and the different places of it, the pain in the right shoulder particularly (28% in the first group, 22% in the second), the intensity in the time and the different requests of analgesics new recorded. The results don't show statistically significant differences and they are different from the gynaecologic ones. The authors suggest, as reasons for these differences, the various moments of the liquid inoculation (at the beginning of the operation in gynaecology, at the end of it in cholecystectomy) and the Trendelemburg position of patients during the gynaecologic operation, on the contrary of cholecystectomy operations. They suggest, in the end, that the trials esecutions on numerically larger groups could bring more significant results.
authors.affiliation: Istituto di Clinica Chirurgica Università degli Studi-Torino.
authors.forename: M
authors.initials: M
authors.lastname: Fornari
authors.forename: C
authors.initials: C
authors.lastname: Miglietta
authors.forename: S
authors.initials: S
authors.lastname: Di Gioia
authors.forename: C
authors.initials: C
authors.lastname: Garrone
authors.forename: M
authors.initials: M
authors.lastname: Morino
mesh_terms: D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D000368:Aged; D000779:Anesthetics, Local / Q000008:administration & dosage*; D002045:Bupivacaine / Q000008:administration & dosage*; D017081:Cholecystectomy, Laparoscopic / Q000009:adverse effects*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007432:Intraoperative Period; D008297:Male; D008875:Middle Aged; D010149:Postoperative Pain / Q000517:prevention & control*
chemical_list: D000779:Anesthetics, Local; D002045:Bupivacaine
vernacular_title: L'utilizzo della bupivacaina per via topica intraoperatoria nel controllo del dolore postoperatorio dopo colecistectomia laparoscopica.