Effects of dietary broccoli on human drug metabolising activity.
Eighteen volunteers received 500 g fresh broccoli every day for 12 days after a 6-day period of standard diet. The activity of CYP1A2, CYP2E1 and the estrone 2 and 16alpha-hydroxylation were determined prior to and after the broccoli diet. The average activity of CYP1A2 and the average 2/16alpha-hydroxyestrone ratio were increased 19% (P < 0.0005) and 29.5% (P < 0.05), respectively; however, no effects were observed on the CYP2E1 activity.
Kall
M A
MA
National Food Agency of Denmark, Mørkhøj Bygade, Søborg.
Vang
O
O
Clausen
J
J
D016588:Anticarcinogenic Agents / Q000378:metabolism*; D001189:Aryl Hydrocarbon Hydroxylases; D019388:Cytochrome P-450 CYP1A2 / Q000378:metabolism*; D065727:Cytochrome P-450 CYP2C8; D065729:Cytochrome P-450 CYP2C9; D019392:Cytochrome P-450 CYP2E1 / Q000378:metabolism*; D004032:Diet; D005982:Glutathione Transferase / Q000097:blood; D006801:Humans; D006894:Hydroxyestrones / Q000378:metabolism*; D007422:Intestines / Q000201:enzymology; D008099:Liver / Q000201:enzymology; D008214:Lymphocytes / Q000201:enzymology; D014675:Vegetables
D016588:Anticarcinogenic Agents; D006894:Hydroxyestrones; C026702:16-hydroxyestrone; C450260:CYP2C9 protein, human; D065729:Cytochrome P-450 CYP2C9; D019392:Cytochrome P-450 CYP2E1; D001189:Aryl Hydrocarbon Hydroxylases; C450259:CYP2C8 protein, human; D019388:Cytochrome P-450 CYP1A2; D065727:Cytochrome P-450 CYP2C8; D005982:Glutathione Transferase; C024980:2-hydroxyestrone