Factor-derived subsyndromes of schizophrenia and familial morbid risks.
Factor analysis was performed on OPCRIT checklist ratings from 66 patients with RDC schizophrenia. Eight substantive factors were found, characterised respectively by: positive formal thought disorder; first rank delusions; first rank hallucinations; inappropriate affect/bizarre behaviour; negative symptoms; grandiose/bizarre delusions; delusions of influence/persecution; and other hallucinations. A history of schizophrenia and other non-affective psychoses was ascertained in the probands' first-degree relatives using a family history approach. Illness in relatives was best predicted by probands' scores on subsyndromes derived from the inappropriate affect/bizarre behaviour and positive formal thought disorder factors.
Cardno
A G
AG
Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff, UK.
Holmans
P A
PA
Harvey
I
I
Williams
M B
MB
Owen
M J
MJ
McGuffin
P
P
D000328:Adult; D016009:Chi-Square Distribution; D003430:Cross-Sectional Studies; D005163:Factor Analysis, Statistical; D005192:Family Health; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D012559:Schizophrenia / Q000145:classification* / Q000235:genetics / Q000503:physiopathology; D006113:United Kingdom