title: Evaluation of the in vitro stability of gadolinium (III) polyoxometalates.
abstract: The gadolinium chelates of lacunary polyoxometalates were evaluated for in vitro stability against rat serum, diethylenetriaminepentaacetic acid (DTPA), endogenous metal cations, and DTPA-doped rat serum. The chelates dissociated rapidly in rat serum. Challenges by DTPA gave relatively slower dissociation rates, whereas challenges by endogenous metal cations (Fe(III), Zn(II), and Cu(II)) occurred at a rate comparable to the serum challenge, suggesting the instability in serum is due to a transmetalation mechanism. Challenges by DTPA-doped serum gave slower rates of dissociation than in native serum, verifying the transmetalation mechanism.
authors.affiliation: Department of Chemistry, Florida State University, Tallahassee 32306, USA.
authors.forename: W J
authors.initials: WJ
authors.lastname: Crooks
authors.forename: G R
authors.initials: GR
authors.lastname: Choppin
authors.forename: B E
authors.initials: BE
authors.lastname: Rogers
authors.forename: M J
authors.initials: MJ
authors.lastname: Welch
mesh_terms: D000818:Animals; D001711:Biotransformation; D004355:Drug Stability; D005682:Gadolinium / Q000097:blood / Q000493:pharmacokinetics*; D005857:Germanium; D008982:Molybdenum; D010087:Oxides / Q000097:blood / Q000493:pharmacokinetics*; D004369:Pentetic Acid / Q000493:pharmacokinetics*; D010758:Phosphorus; D011868:Radioisotopes / Q000097:blood / Q000493:pharmacokinetics*; D051381:Rats; D012825:Silicon; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D014414:Tungsten
chemical_list: D010087:Oxides; D011868:Radioisotopes; D005857:Germanium; D010758:Phosphorus; D004369:Pentetic Acid; D008982:Molybdenum; D005682:Gadolinium; D014414:Tungsten; D012825:Silicon