Cobalt-55 positron emission tomography in ischemic stroke.
After acute cerebral stroke, the (peri-) infarct tissue is characterized by calcium (Ca)-mediated neuronal damage and inflammatory processes. Monitoring Ca-mediated damage using the isotope cobalt-55 (Co) as a Ca-tracer may enable PET-imaging of this tissue. Since the fate of (peri-) infarct tissue determines clinical outcome, Co-PET may have prognostic value in stroke. Six stroke patients were examined with Co-PET, MRI and a middle cerebral artery (mca) stroke scale (Orgogozo). In every patient, specific Co-accumulation in the appropriate brain region was seen, irrespective of the integrity of the blood-brain barrier. This pilot study suggests Co-PET as a diagnostic tool in stroke, which may provide additional information on the clinical outcome. Validation of method in larger patient series is necessary.
Jansen
H M
HM
Department of Neurology, Groningen University Hospital, The Netherlands.
Paans
A M
AM
vd Vliet
A M
AM
Veenma-van der Duin
L
L
Bolwijn-Meijer
C J
CJ
Pruim
J
J
Willemsen
A T
AT
Franssen
E J
EJ
Minderhoud
J M
JM
Korf
J
J
D000368:Aged; D000369:Aged, 80 and over; D001812:Blood-Brain Barrier / Q000502:physiology; D001925:Brain Damage, Chronic / Q000000981:diagnostic imaging* / Q000503:physiopathology; D001931:Brain Mapping; D015220:Calcium Channels / Q000502:physiology*; D016893:Carotid Stenosis / Q000000981:diagnostic imaging / Q000503:physiopathology; D002540:Cerebral Cortex / Q000098:blood supply / Q000000981:diagnostic imaging; D002544:Cerebral Infarction / Q000000981:diagnostic imaging* / Q000503:physiopathology; D003037:Cobalt Radioisotopes; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D012039:Regional Blood Flow / Q000502:physiology; D014022:Tissue Survival / Q000502:physiology; D014055:Tomography, Emission-Computed / Q000379:methods*
D015220:Calcium Channels; D003037:Cobalt Radioisotopes