title: Congenital leukaemia with a mixed phenotype of megakaryoblasts and erythroblasts: a case report and characterization of the blasts.
abstract: We present a congenital leukaemia with a mixed phenotype of megakaryoblasts and erythroblasts. A newborn male with exopthalmus and multiple skin nodules, had bone marrow blasts which expressed CD41b, CD42b, glycophorin-A and haemoglobin, but monocyte or lymphoid markers were negative. The patient achieved a complete remission with chemotherapy. Blasts cultured for a few months expressed erythroid markers but lost the megakaryocytic phenotype, although addition of phorbol ester induced the latter phenotype. Spontaneous colony formation was observed in semi-solid culture and the number of colonies was increased by erythropoietin. Detailed studies further indicated the heterogeneity of congenital leukaemia.
authors.affiliation: Department of Haematology and Oncology, National Children's Hospital, Tokyo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Mori
authors.forename: H
authors.initials: H
authors.lastname: Kaneko
authors.forename: M A
authors.initials: MA
authors.lastname: Kumagai
authors.forename: J
authors.initials: J
authors.lastname: Miyauchi
authors.forename: Y
authors.initials: Y
authors.lastname: Kaneko
authors.forename: J
authors.initials: J
authors.lastname: Fujimoto
authors.forename: Y
authors.initials: Y
authors.lastname: Tsunematsu
mesh_terms: D004900:Erythroblasts / Q000473:pathology*; D006801:Humans; D007231:Infant, Newborn; D007938:Leukemia / Q000151:congenital* / Q000473:pathology; D008297:Male; D008533:Megakaryocytes / Q000473:pathology*; D010641:Phenotype; D014407:Tumor Cells, Cultured