New antihepatotoxic cerebroside from Lycium chinense fruits.
Two cerebrosides isolated from Lycium chinense fruits have been characterized as 1-O-beta-D-glucopyranosyl-(2S, 3R,4E,8Z)-2-N-palmitoyloctadecasphinga-4,8-dienine+ ++ (1) and 1-O-beta-D-glucopyranosyl -(2S,3R,4E,8Z)-2-N-(2'-hydroxypalmitoyl)octadecasph inga-4,8-dienine (2). While 2 is already known, the structure of 1 was determined by spectral and chemical studies. Incubation of CCl4-intoxicated hepatocytes with 1 and 2, respectively, significantly reduced the levels of glutamic pyruvic transaminase (GPT) and sorbitol dehydrogenase (SDH) released by injured cells.
Kim
S Y
SY
College of Pharmacy, Seoul National University, Korea.
Choi
Y H
YH
Huh
H
H
Kim
J
J
Kim
Y C
YC
Lee
H S
HS
D000818:Animals; D002478:Cells, Cultured; D002554:Cerebrosides / Q000302:isolation & purification* / Q000494:pharmacology; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy*; D006868:Hydrolysis; D008099:Liver / Q000166:cytology / Q000187:drug effects / Q000201:enzymology; D009682:Magnetic Resonance Spectroscopy; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D016339:Spectrometry, Mass, Fast Atom Bombardment
C105636:1-O-glucopyranosyl-2-N-palmitoyloctadecasphinga-4,8-dienine; D002554:Cerebrosides; C068190:soya-cerebroside I