Synthesis of some new 2-methyl-4-(substituted benzylidene)1-phenyl-1,2,4 triazolo (3,4,-b) 1,4,5 thiadiazole as potential AChE inhibitory agents.
4-(1-aminophenyl)-1,2,4-triazolo[3,4,-b]1,3,4-thiadiozole (2) was prepared by treatment of 4-(1-aminophenyl)-5-mercapto-4-amino-1,2,4-S-triazole with carbondisulfide and KOH in methanol. This on further reaction with different 2-methyl-4-(substituted benzylidene)-oxazolin-5-ones gave 2-methyl-4-(substituted benzylidene)-1-phenyl-1,2,4[triazolo[3,4,-b]1,3,4-thiadiozoles. The compounds were screened for AChE inhibitory activity.
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Renu Tiwari, Department of Chemistry, Luicknow University, India.
Shanker
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D000818:Animals; D001597:Benzylidene Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D001921:Brain / Q000187:drug effects / Q000201:enzymology; D002800:Cholinesterase Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D013830:Thiadiazoles / Q000138:chemical synthesis* / Q000494:pharmacology
D001597:Benzylidene Compounds; D002800:Cholinesterase Inhibitors; D013830:Thiadiazoles