title: Lipoprotein glomerulopathy: a pediatric case report.
abstract: We report an 8-year-old girl with lipoprotein glomerulopathy who may have developed this condition as young as 4 years of age. To our knowledge this is the youngest reported case of this disease. Lipid studies of the patient and her family members revealed elevated concentrations of apolipoprotein E (apo E), the apo E phenotype E2/3, and the genotype E3/3. However, other families revealed no urinary abnormalities. Our findings suggest that an apo E abnormality may be responsible for the development of lipoprotein glomerulopathy. Genetic analysis of apo E is needed to clarify the pathogenesis.
authors.affiliation: Department of Pediatrics, Gunma University School of Medicine, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Maruyama
authors.forename: H
authors.initials: H
authors.lastname: Arai
authors.forename: T
authors.initials: T
authors.lastname: Ogawa
authors.forename: S
authors.initials: S
authors.lastname: Tomizawa
authors.forename: A
authors.initials: A
authors.lastname: Morikawa
mesh_terms: D001053:Apolipoproteins / Q000097:blood; D001057:Apolipoproteins E / Q000097:blood / Q000235:genetics; D002648:Child; D005260:Female; D006801:Humans; D007668:Kidney / Q000473:pathology; D007674:Kidney Diseases / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D008074:Lipoproteins / Q000097:blood / Q000378:metabolism*; D010641:Phenotype
chemical_list: D001053:Apolipoproteins; D001057:Apolipoproteins E; D008074:Lipoproteins