Radiographic assessment in osteoarthritis.
Plain film radiographs are widely used to quantify disease progression in osteoarthritis. Various methods proposed for assessing radiological progression include individual radiographic features (e.g., osteophytes), composite indices (e.g., Kellgren and Lawrence grading), and quantitative measures (e.g., joint space width measurement). We discuss the metrologic properties of these methods and suggest means for improving the quality of radiography in clinical trials.
Ravaud
P
P
Clinique de Rhumatologie, Hôpital Cochin, Paris, France.
Dougados
M
M
D002986:Clinical Trials as Topic / Q000379:methods*; D018450:Disease Progression; D006801:Humans; D010003:Osteoarthritis / Q000000981:diagnostic imaging*; D011379:Prognosis; D011859:Radiography; D012680:Sensitivity and Specificity; D016896:Treatment Outcome