title: [Mumps epidemic in the health area of Toledo with immunization intervention. Estimation of vaccine effectiveness].
abstract: BACKGROUND
  The aim of this study was to describe a mumps epidemic occurred among school children in Toledo, Spain, between 1993 and 1994 were vaccination was undertaken as control measure, and to estimate vaccine efficacy under field conditions.
  
  
  METHODS
  Attack rates for vaccinated (at 15 months of age) and unvaccinated population were calculated. A retrospective cohort study was designed to estimate vaccine efficacy.
  
  
  RESULTS
  A total of 19 outbreaks in different schools were declared. 216 cases and 4,059 contacts, between 10-17 years old, were investigated. The attack rate for the school population was 5.3%. By age, the highest attack rate was for those in the 12-13 age group (7.9%). Estimated vaccine efficacy was 76% (95% confidence interval 66-87%) for the whole study population: For children among 10-13 years old it was 87% (95% confidence interval 76-93%), and 46% (95% confidence interval 20-70%) for those aged 14-17 years.
  
  
  CONCLUSIONS
  Vaccination is a good control measure in mumps outbreaks (the attack rate for the study population was 5.1%). Vaccine efficacy was high for the 10-13 age group and in agreement with the results of seroepidemiological studies.
authors.affiliation: Sección de Información Sanitaria y Vigilancia Epidemiológica, Delegación Provincial de Sanidad de Toledo.
authors.forename: K
authors.initials: K
authors.lastname: Fernández de la Hoz Zeitler
authors.forename: C
authors.initials: C
authors.lastname: García Colmenero
authors.forename: M J
authors.initials: MJ
authors.lastname: Puchades Belenguer
authors.forename: C
authors.initials: C
authors.lastname: Verde López
authors.forename: J L
authors.initials: JL
authors.lastname: Carpintero Redondo
authors.forename: F
authors.initials: F
authors.lastname: Alcázar Casanova
mesh_terms: D000293:Adolescent; D002648:Child; D015331:Cohort Studies; D016001:Confidence Intervals; D004196:Disease Outbreaks; D005069:Evaluation Studies as Topic; D006801:Humans; D007223:Infant; D009107:Mumps / Q000453:epidemiology* / Q000517:prevention & control; D009108:Mumps Vaccine / Q000008:administration & dosage*; D012189:Retrospective Studies; D013030:Spain / Q000453:epidemiology
chemical_list: D009108:Mumps Vaccine
vernacular_title: Epidemia de parotiditis en el área sanitaria de Toledo con intervención mediante inmunización. Estimación de la efectividad de la vacuna.