title: [Metalloproteinases in the extracellular matrix: structure and activity].
abstract: The matrix metalloproteinases (MMP) are a multigenic family involving 14 enzymes which can cleave most, if not all, the components of the extracellular matrix (interstitium and basement membranes). The present work reports on the main structural characteristics, the substrate preference and the site synthesis of these proteinases and their inhibitors (TIMP). Human MMPs are produced by various cell types and are involved in the remodelling of the extracellular matrix in many physiological and pathophysiological circumstances. Elastolytic MMPs produced by monocytes and/or macrophages (matrilysin, gelatinases, macrophage elastase) are likely to be implicated in the development of acquired pulmonary emphysema.
authors.affiliation: Unité INSERM 295, Faculté de Médecine de Rouen, Saint-Etienne du Rouvray.
authors.forename: A
authors.initials: A
authors.lastname: Cuvelier
authors.forename: C
authors.initials: C
authors.lastname: Kuntz
authors.forename: R
authors.initials: R
authors.lastname: Sesboüé
authors.forename: J F
authors.initials: JF
authors.lastname: Muir
authors.forename: J P
authors.initials: JP
authors.lastname: Martin
mesh_terms: D005109:Extracellular Matrix / Q000201:enzymology*; D006801:Humans; D008666:Metalloendopeptidases / Q000037:antagonists & inhibitors / Q000737:chemistry* / Q000145:classification / Q000502:physiology*; D011656:Pulmonary Emphysema / Q000201:enzymology; D013379:Substrate Specificity
chemical_list: D008666:Metalloendopeptidases
vernacular_title: Les métalloprotéinases de la matrice extracellulaire (MMP): structure et activité.