The inducible form of nitric oxide synthase (NOS2) isolated from murine macrophages maps near the nude mutation on mouse chromosome 11.
Nitric oxide synthase has been shown to mediate streptozocin-induced diabetes and to act as an antimicrobial agent in murine macrophages. Using a cDNA probe for the inducible form of nitric oxide synthase (Nos2) isolated from murine macrophages we have determined that the gene maps within 1 cM of the nude mutation on mouse Chromosome 11. The position of Nos2 was also mapped relative to the markers 115, Evi2, Cchlbl (previously unmapped), and Gfap. This map location is discussed relative to map locations for disease susceptibility loci involved in mediating cutaneous leishmaniasis (ScII) and autoimmune type-I diabetes (Idd4).
Mock
B A
BA
Laboratory of Genetics, NCI, National Institutes of Health, Bethesda, MD 20892, USA.
Krall
M M
MM
Byrd
L G
LG
Chin
H
H
Barton
C H
CH
Charles
I
I
Liew
F Y
FY
Blackwell
J
J
D000818:Animals; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics; D004790:Enzyme Induction / Q000235:genetics; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D016773:Leishmaniasis, Cutaneous / Q000235:genetics; D008264:Macrophages / Q000201:enzymology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude / Q000235:genetics*; D009115:Muridae; D019001:Nitric Oxide Synthase / Q000096:biosynthesis / Q000235:genetics*
D005819:Genetic Markers; D019001:Nitric Oxide Synthase