title: Rising serum values of beta-subunit human chorionic gonadotrophin (hCG) in patients with progressive vulvar carcinomas.
abstract: Elevated serum levels of the beta-subunit of human chorionic gonadotrophin (hCG) were measured in 50% of patients with locoregional recurrences or progressive vulvar carcinoma (n = 14). At diagnosis of vulvar cancer, however, the incidence of elevated serum levels was low (5%) in 104 patients. The rising serum levels during progression of disease indicate that the synthesis of the beta-subunit hCG can be increased in vulvar carcinoma.
authors.affiliation: Department of Obstetrics and Gynaecology, University Hospital Groningen, The Netherlands.
authors.forename: H W
authors.initials: HW
authors.lastname: de Bruijn
authors.forename: K A
authors.initials: KA
authors.lastname: ten Hoor
authors.forename: M
authors.initials: M
authors.lastname: Krans
authors.forename: A G
authors.initials: AG
authors.lastname: van der Zee
mesh_terms: D014408:Biomarkers, Tumor; D002294:Carcinoma, Squamous Cell / Q000097:blood* / Q000503:physiopathology / Q000601:surgery; D018997:Chorionic Gonadotropin, beta Subunit, Human / Q000097:blood*; D018450:Disease Progression; D005260:Female; D006801:Humans; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D014846:Vulvar Neoplasms / Q000097:blood* / Q000503:physiopathology / Q000601:surgery
chemical_list: D014408:Biomarkers, Tumor; D018997:Chorionic Gonadotropin, beta Subunit, Human