title: Parathormone, 1,25 dihydroxyvitamin D and prostaglandin E2 correlation in children with idiopathic hypercalciuria.
abstract: As urinary prostaglandin excretion might be involved in idiopathic hypercalciuria, we studied the excretion of prostaglandin E2 and calcium together with serum prostaglandin E2, parathormone and 1,25 dihydroxyvitamin D in 20 patients and 11 controls Idiopathic hypercalciuric patients showed increased levels of urinary prostaglandin E2-like activity, which is correlated with calcium excretion. Although no change was observed in serum parathormone level in control and hypercalciuric patients, there was a positive correlation between serum 1,25 dihydroxyvitamin D and prostaglandin E2-like activity. These findings suggest that prostaglandin E2 could play a role in the hypercalciuria syndrome, possibly by increasing 1,25 dihydroxyvitamin D synthesis.
authors.affiliation: Department of Paediatry, Faculty of Medicine, Gazi University Ankara, Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Hasanoğlu
authors.forename: Z S
authors.initials: ZS
authors.lastname: Ercan
authors.forename: N
authors.initials: N
authors.lastname: Buyan
authors.forename: N
authors.initials: N
authors.lastname: Memioğlu
authors.forename: E
authors.initials: E
authors.lastname: Hasanoğlu
mesh_terms: D002117:Calcitriol / Q000097:blood*; D002118:Calcium / Q000652:urine*; D016022:Case-Control Studies; D002648:Child; D015232:Dinoprostone / Q000097:blood* / Q000652:urine*; D005260:Female; D006801:Humans; D008297:Male; D010281:Parathyroid Hormone / Q000097:blood*; D013577:Syndrome
chemical_list: D010281:Parathyroid Hormone; D002117:Calcitriol; D015232:Dinoprostone; D002118:Calcium