Splicing together the unfolded-protein response.
Recent work has identified a transcription factor, Hac1p, in the yeast Saccharomyces cerevisiae, as a component of a pathway that signals to the nucleus the presence of unfolded proteins in the endoplasmic reticulum and has shown that Hac1p expression is regulated by a novel RNA splicing pathway.
Shamu
C E
CE
Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA. shamu@bcmp.med.harvard.edu
D050976:Basic-Leucine Zipper Transcription Factors; D002467:Cell Nucleus / Q000502:physiology; D004721:Endoplasmic Reticulum / Q000502:physiology; D005656:Fungal Proteins / Q000096:biosynthesis / Q000502:physiology*; D015966:Gene Expression Regulation, Fungal; D016350:Leucine Zippers; D008954:Models, Biological; D017510:Protein Folding; D012326:RNA Splicing; D012333:RNA, Messenger / Q000096:biosynthesis; D012097:Repressor Proteins / Q000096:biosynthesis / Q000502:physiology*; D012441:Saccharomyces cerevisiae / Q000502:physiology* / Q000648:ultrastructure; D029701:Saccharomyces cerevisiae Proteins; D015398:Signal Transduction; D014157:Transcription Factors
D050976:Basic-Leucine Zipper Transcription Factors; D005656:Fungal Proteins; C091341:HAC1 protein, S cerevisiae; D012333:RNA, Messenger; D012097:Repressor Proteins; D029701:Saccharomyces cerevisiae Proteins; D014157:Transcription Factors