title: Fractures and phenylketonuria.
abstract: Parent or self-reported history of fractures in a group of patients aged from 0.3 to 33.6 years on dietary treatment for phenylketonuria was studied by means of a questionnaire. Twenty-one of 85 patients had a history of fracture compared with 18/98 sibling controls. There was no significant difference in the lifetime risk of fracture between patients and controls (chi 2 = 1.43, df = 1, p = 0.23), but a significantly higher risk of fracture was reported over the age of 8 y (chi 2 = 5.11, df = 1, p = 0.024), with a relative risk of 2.6 (95% confidence interval 1.1.6.1). We suggest this may be related either to deterioration in dietary control in this age group or to a cumulative disease-related or diet-related reduction in bone mass.
authors.affiliation: Royal Belfast Hospital for Sick Children, Department of Child Health, UK.
authors.forename: L G
authors.initials: LG
authors.lastname: Greeves
authors.forename: D J
authors.initials: DJ
authors.lastname: Carson
authors.forename: A
authors.initials: A
authors.lastname: Magee
authors.forename: C C
authors.initials: CC
authors.lastname: Patterson
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D015519:Bone Density; D002648:Child; D002675:Child, Preschool; D004035:Diet Therapy / Q000009:adverse effects; D050723:Fractures, Bone / Q000150:complications* / Q000209:etiology; D006801:Humans; D007223:Infant; D010661:Phenylketonurias / Q000150:complications* / Q000628:therapy; D012307:Risk Factors