[Influence of anemia on hemodynamic changes in patients with cirrhosis].
OBJECTIVE
The aim of this retrospective study was to evaluate the systemic and splanchnic hemodynamic changes induced by anemia in patients with cirrhosis.


METHODS
148 patients (Child-Pugh A: 46 patients, Child-Pugh B: 64 patients and Child-Pugh C: 38 patients) were included in the study. Anemia was defined by a blood hemoglobin level < 12 g/dL. A systemic and splanchnic hemodynamic study was performed in all patients.


RESULTS
A significant elevation of the hepatic venous pressure gradient was observed in Child-Pugh A patients with anemia but not in Child-Pugh B and C patients. In the 2 latter groups, cardiac index was significantly increased and systemic vascular resistance decreased in patients with anemia.


CONCLUSIONS
Anemia may worsen the hemodynamic changes associated with cirrhosis.
Denié
C
C
Laboratoire d'Hémodynamique Splanchnique, Unité de Recherche de Physiopathologie Hépatique, INSERM U-24, Clichy.
Poynard
T
T
Gadano
A
A
Vachiery
F
F
Soupison
T
T
Elman
A
A
Valla
D
D
Moreau
R
R
Lebrec
D
D
D000328:Adult; D000740:Anemia / Q000209:etiology / Q000503:physiopathology*; D005260:Female; D006439:Hemodynamics; D006509:Hepatitis B / Q000150:complications; D006526:Hepatitis C / Q000150:complications; D006801:Humans; D006975:Hypertension, Portal / Q000209:etiology / Q000503:physiopathology; D008103:Liver Cirrhosis / Q000150:complications / Q000503:physiopathology*; D008104:Liver Cirrhosis, Alcoholic / Q000150:complications / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013152:Splanchnic Circulation; D014655:Vascular Resistance
Influence de l'anémie sur les modifications hémodynamiques des malades atteints de cirrhose.