Early effects of ganciclovir therapy on the quantity of cytomegalovirus DNA in leukocytes of immunocompromised patients.
The cytomegalovirus (CMV) DNA load in leukocytes was measured in 26 immunocompromised patients with CMV disease before and after 10 days of intravenous ganciclovir therapy. Before therapy, the circulating DNA burden of bone marrow transplant recipients was significantly lower than that of other transplant or AIDS patients. Ganciclovir induction therapy significantly decreased the viral DNA load in the leukocyte populations of most patients.
Boivin
G
G
Department of Microbiology, Université Laval, Quebec City, Quebec, Canada.
Quirk
M R
MR
Kringstad
B A
BA
Germain
M
M
Jordan
M C
MC
D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology / Q000378:metabolism; D000998:Antiviral Agents / Q000627:therapeutic use*; D016026:Bone Marrow Transplantation / Q000276:immunology; D003587:Cytomegalovirus / Q000378:metabolism*; D003586:Cytomegalovirus Infections / Q000188:drug therapy / Q000378:metabolism / Q000821:virology*; D004279:DNA, Viral / Q000032:analysis / Q000378:metabolism*; D015774:Ganciclovir / Q000627:therapeutic use*; D006801:Humans; D007962:Leukocytes / Q000737:chemistry / Q000378:metabolism*; D009504:Neutrophils / Q000737:chemistry / Q000378:metabolism; D016377:Organ Transplantation / Q000502:physiology; D016133:Polymerase Chain Reaction
D000998:Antiviral Agents; D004279:DNA, Viral; D015774:Ganciclovir