Gene of LukF-PV-like component of Panton-Valentine leukocidin in Staphylococcus aureus P83 is linked with lukM.
Staphylococcus aureus P83 (ATCC 31890) produces five components, I to V for synergistic toxins, leukocidin and gamma-hemolysin [Sudo et al., Biosci. Biotech. Biochem., 56, 1786-1789 (1995)]. We report here the identification of component II, which is designated LukF-PV(P83) and its gene (lukF-PV(P83)). The lukF-PV(P83) gene was found to be one base downstream of the stop codon of the lukM gene. The deduced amino acid sequence of LukF-PV(P83) showed 78.4% identity with that of LukF-PV. The lukM and lukF-PV(P83) genes were encoded as one operon like that of Panton-Valentine leukocidin.
Kaneko
J
J
Department of Applied Biological Chemistry, Faculty of Agriculture, Tohoku University, Sendai, Japan.
Muramoto
K
K
Kamio
Y
Y
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D015153:Blotting, Western; D004591:Electrophoresis, Polyacrylamide Gel; D004912:Erythrocytes / Q000166:cytology / Q000187:drug effects; D006461:Hemolysis / Q000187:drug effects; D007956:Leukocidins / Q000737:chemistry / Q000235:genetics* / Q000633:toxicity; D008969:Molecular Sequence Data; D008970:Molecular Weight; D011817:Rabbits; D013211:Staphylococcus aureus / Q000235:genetics* / Q000378:metabolism
D007956:Leukocidins