title: Signet-ring cell carcinoma of the endometrium: a primary tumor masquerading as a metastasis.
abstract: Extragenital metastases to the endometrium are unusual, but several histologic features have been suggested as highly suggestive or even pathognomonic for this diagnosis. We report an endometrial carcinoma with a prominent signet-ring cell morphology and a diffusely permeative pattern of infiltration, features that have been reported as indicating an extragenital metastasis. To the best of our knowledge, this is the first reported case of a signet-ring cell carcinoma of the endometrium. Gynecological pathologists should be aware of this entity because of its potential primary of metastatic signet-ring carcinoma to be endometrium.
authors.affiliation: Department of Pathology, Duke University Medical Center, Durham, North Carolina 27710, USA.
authors.forename: E E
authors.initials: EE
authors.lastname: Mooney
authors.forename: S J
authors.initials: SJ
authors.lastname: Robboy
authors.forename: C B
authors.initials: CB
authors.lastname: Hammond
authors.forename: A
authors.initials: A
authors.lastname: Berchuck
authors.forename: R C
authors.initials: RC
authors.lastname: Bentley
mesh_terms: D000368:Aged; D001706:Biopsy; D018279:Carcinoma, Signet Ring Cell / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D003937:Diagnosis, Differential; D016889:Endometrial Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D007044:Hysterectomy; D009362:Neoplasm Metastasis