Variable effects of iodinated contrast media on different rabbit arteries in vitro.
Vasoconstriction caused by iodinated contrast media (CM) has been considered specific for the renal artery only. We examined the vascular effect of CM in rabbit carotid, aorta, renal, iliac, mesenteric and celiac arteries and found that other arteries also respond with a contraction to CM. Isolated arterial rings were exposed to diatrizoate (high osmolar CM), iohexol (low osmolar CM) or glucose solution, and the isometric contraction response was expressed as percentage of an initial KCl control contraction. Diatrizoate evoked contractions of 82% (carotid), 63% (aorta), 30% (renal), 24% (iliac), 28% (mesenteric) and 18% (celiac), respectively. Iohexol caused contractions of 31% (carotid), 24% (aorta), 15% (renal) and 14% (iliac), whereas the mesenteric and celiac arteries were relaxed by iohexol. A high osmolar glucose solution elicited contractions of 78%, 77%, 11%, 27%, 3% and 5%, respectively, in the arteries. CM have contraction potency in arterial vasculature other than the renal artery.
Rauch
D
D
Department of Surgery, University of Wisconsin, School of Medicine and VA Medical Center, Madison 53705, USA.
Drescher
P
P
Knes
J M
JM
Madsen
P O
PO
D000818:Animals; D001011:Aorta / Q000187:drug effects / Q000502:physiology; D001158:Arteries / Q000187:drug effects / Q000502:physiology*; D002339:Carotid Arteries / Q000187:drug effects / Q000502:physiology; D002445:Celiac Artery / Q000187:drug effects / Q000502:physiology; D003287:Contrast Media / Q000494:pharmacology*; D003973:Diatrizoate / Q000494:pharmacology; D005947:Glucose / Q000494:pharmacology; D007083:Iliac Artery / Q000187:drug effects / Q000502:physiology; D066298:In Vitro Techniques; D007472:Iohexol / Q000494:pharmacology; D008638:Mesenteric Arteries / Q000187:drug effects / Q000502:physiology; D008954:Models, Biological; D009994:Osmolar Concentration; D011817:Rabbits; D012077:Renal Artery / Q000187:drug effects / Q000502:physiology; D014661:Vasoconstriction / Q000187:drug effects*
D003287:Contrast Media; D003973:Diatrizoate; D007472:Iohexol; D005947:Glucose