title: Breast implants in patients with differentiated and undifferentiated connective tissue disease.
abstract: OBJECTIVE
  To assess the frequency of breast implantation and the relationship of the implants to the onset of symptoms in patients with differentiated and undifferentiated connective tissue disease (CTD).
  
  
  METHODS
  We evaluated an inception cohort of patients with differentiated and undifferentiated CTD and symptoms of < 12 months duration when enrolled in 1983-1987. The risk of having breast implants in those patients with early symptoms of CTD was determined in comparison with that in a non-concurrent control group.
  
  
  RESULTS
  Only 3 of 323 women in the cohort had historical, physical, or chest radiographic evidence of breast implantation. In 1 of the 3 patients, the symptoms of CTD began before the breast implantation. The odds ratio was calculated at 1.15, with a 95% confidence interval ranging from 0.23 to 3.41.
  
  
  CONCLUSIONS
  This study showed an absence of significant risk for prior breast implantation surgery in patients with well-defined or undifferentiated CTD.
authors.affiliation: University of Utah School of Medicine, Salt Lake City 84132, USA.
authors.forename: H J
authors.initials: HJ
authors.lastname: Williams
authors.forename: M H
authors.initials: MH
authors.lastname: Weisman
authors.forename: C C
authors.initials: CC
authors.lastname: Berry
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001706:Biopsy; D001940:Breast / Q000473:pathology; D018427:Breast Implants / Q000009:adverse effects; D015331:Cohort Studies; D003240:Connective Tissue Diseases / Q000453:epidemiology* / Q000209:etiology; D005260:Female; D006801:Humans; D008875:Middle Aged; D015337:Multicenter Studies as Topic; D012307:Risk Factors; D012828:Silicones
chemical_list: D012828:Silicones