title: Multicentric Castleman's disease with an increased serum level of macrophage colony-stimulating factor.
abstract: We describe a 74-year-old patient with multicentric Castleman's disease (MCD) whose serum macrophage colony-stimulating factor level was elevated. Serum levels of tumor necrosis factor-alpha and interleukin 6 were also elevated at presentation, and they returned to normal levels after chemotherapy. Although the total serum cholesterol level was below normal on admission, it increased after chemotherapy. These results suggest that the activation of monocytes or macrophages may be involved in certain pathological phenomena in MCD.
authors.affiliation: Department of Internal Medicine, Hakodate Municipal Hospital, Hokkaido, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Lee
authors.forename: M
authors.initials: M
authors.lastname: Hirokawa
authors.forename: S
authors.initials: S
authors.lastname: Matuoka
authors.forename: H
authors.initials: H
authors.lastname: Hasegawa
authors.forename: H
authors.initials: H
authors.lastname: Nanjo
authors.forename: T
authors.initials: T
authors.lastname: Matsushima
authors.forename: H
authors.initials: H
authors.lastname: Imatani
authors.forename: A B
authors.initials: AB
authors.lastname: Miura
mesh_terms: D000368:Aged; D005871:Castleman Disease / Q000097:blood* / Q000503:physiopathology; D006801:Humans; D016173:Macrophage Colony-Stimulating Factor / Q000097:blood*; D008297:Male
chemical_list: D016173:Macrophage Colony-Stimulating Factor