[Kinetics of elimination of diazepam after intravenous injection in horses].
Diazepam is used in veterinary medicine as sedative and pre-anaesthetic agent. This publication describes the plasma-concentration time curve for diazepam and its metabolite in horses suffering from colic after intravenous application as pre-anaesthetic agent. Elimination half-life (t1/2 beta) after a dose of 0.05-0.08 mg/kg (30-50 mg Diazepam per horse) was 7.5 to 13.2 h. Total clearance (Cltot) between 1.86 and 3.44 ml/min/kg was detected and apparent volume of distribution in steady state (Vdiss) was 1.98 to 2.25 l/kg. Diazepam was still found in serum after 24 h. The metabolite oxazepam could be found in plasma. Its elimination half-life was 14-16.5 hours.
Shini
S
S
Stipendiatin der Katholischen Akademischen Austauschdienstes Res. (KAAD), Veterinärmedizinischen Fakultät der agrarwissenschaftlichen Universität Tirana, Albanien.
Klaus
A M
AM
Hapke
H J
HJ
D000759:Adjuvants, Anesthesia / Q000008:administration & dosage / Q000493:pharmacokinetics*; D000818:Animals; D003975:Diazepam / Q000008:administration & dosage / Q000493:pharmacokinetics*; D006207:Half-Life; D006736:Horses; D006993:Hypnotics and Sedatives / Q000008:administration & dosage / Q000493:pharmacokinetics*; D007275:Injections, Intravenous; D008657:Metabolic Clearance Rate; D010076:Oxazepam / Q000097:blood
D000759:Adjuvants, Anesthesia; D006993:Hypnotics and Sedatives; D010076:Oxazepam; D003975:Diazepam
Eliminationskinetik von Diazepam nach intravenöser Applikation beim Pferd.