Increases in the effects of albendazole on Echinococcus multilocularis metacestodes by the dipeptide methyl ester (Phe-Phe-OMe).
Three months after infection with Echinococcus multilocularis, Mongolian gerbils were given either the dipeptide methyl ester (Phe-Phe-OMe) or a combination of Phe-Phe-OMe plus albendazole to treat alveolar echinococcosis. Each drug was given orally at the daily dose of 50 mg/kg of body weight following various administration regimens. Histologic and ultrastructural studies of parasites recovered from infected gerbil tissues showed that the dipeptide methyl ester increases the effect of albendazole.
Sarciron
M E
ME
Department of Parasitology and Medical Mycology, Claude Bernard University, Lyon, France.
Walchshofer
N
N
Walbaum
S
S
Arsac
C
C
Descotes
J
J
Petavy
A F
AF
Paris
J
J
D015766:Albendazole / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D000818:Animals; D000871:Anthelmintics / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D004151:Dipeptides / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D004338:Drug Combinations; D004444:Echinococcosis, Hepatic / Q000188:drug therapy*; D004446:Echinococcus / Q000187:drug effects* / Q000648:ultrastructure; D005260:Female; D005849:Gerbillinae; D008297:Male; D051379:Mice; D008854:Microscopy, Electron; D015842:Serine Proteinase Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity
D000871:Anthelmintics; D004151:Dipeptides; D004338:Drug Combinations; D015842:Serine Proteinase Inhibitors; C063009:phenylalanylphenylalanine methyl ester; D015766:Albendazole