[Surgical treatment of primary hyperparathyroidism].
Neck exploration due to suspicion of primary hyperparathyroidism (pHPT) was performed in 309 instances (298 patients) during a 17 year period, in 44 instances (14%) as a second operation after former goitre surgery or surgery for pHPT. Adenomas were found in 247 patients (83%), 12 patients had double adenomas and one triple adenoma. Hyperplasia was registered in 34 patients (11%) and three had parathyroid cancer. Median weight of adenomas was 1200 mg and hyperplasia 1500 mg. In 14 patients only normal glands were identified. In six of these 14 patients the diagnosis was later withdrawn. In 276 out of 292 patients with pHPT normocalcaemia was established, 16 patients remained hypercalcaemic. Success-rate concerning verification of pHPT was therefore 97% (284 out of 292) and concerning attainment of normocalcaemia 95% (276 out of 292). There was one perioperative death due to myocardial infarction. Four patients had transient unilateral recurrent nerve injury. In one patient with parathyroid cancer vocal cord paralysis was permanent. Follow-up after at least one year revealed normocalcaemia in 91% of the patients, hypercalcaemia in 7% and hypocalcaemia in 2%. Twenty percent of the patients had died 0-12 years, median 2.8 years postoperatively. Death was related to the degree of hyperparathyroidism evaluated by weight of abnormal parathyroid tissue.
Mollerup
C L
CL
Kirurgisk afdeling D, Rigshospitalet.
Antonsen
H K
HK
Graversen
H P
HP
Blichert-Toft
M
M
D000236:Adenoma / Q000150:complications / Q000473:pathology / Q000601:surgery; D000293:Adolescent; D000328:Adult; D000368:Aged; D006801:Humans; D006934:Hypercalcemia; D006961:Hyperparathyroidism / Q000097:blood / Q000209:etiology / Q000601:surgery*; D006965:Hyperplasia; D008875:Middle Aged; D010280:Parathyroid Glands / Q000473:pathology; D010282:Parathyroid Neoplasms / Q000150:complications / Q000473:pathology / Q000601:surgery; D016105:Parathyroidectomy; D011183:Postoperative Complications / Q000175:diagnosis
Kirurgisk behandling af primaer hyperparatyreoidisme.