Correlation of interleukin-6 serum levels with bone density in postmenopausal women.
In order to identify possible correlations between interleukin-6 (IL-6) and hormonal and biochemical parameters of bone metabolism, or bone density, 24 postmenopausal women were studied. Serum IL-6, estradiol, calcium, phosphorus, osteocalcin, alkaline phosphatase, the urinary secretion of calcium, phosphorus and hydroxyproline, and bone density of the lumbar spine, femur and radius were measured. No significant correlation was found between IL-6 and the biochemical parameters. A negative correlation was found between IL-6 and serum estradiol, as well as between IL-6 and bone density in 5 out of 6 sites studied. It is possible that women with high IL-6 levels, may develop lower bone mass.
Papadopoulos
N G
NG
Garofalidis Research Centre, University of Athens, Greece.
Georganas
K
K
Skoutellas
V
V
Konstantellos
E
E
Lyritis
G P
GP
D015502:Absorptiometry, Photon; D000328:Adult; D000367:Age Factors; D015415:Biomarkers / Q000032:analysis; D015519:Bone Density; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D008875:Middle Aged; D010024:Osteoporosis / Q000175:diagnosis; D017698:Postmenopause
D015415:Biomarkers; D015850:Interleukin-6