Cystic squamous cell carcinomas in the lungs of Syrian golden hamsters induced by coal oven flue exhaust mixed with pyrolized tar pitch in combination with benzo(a)pyrene.
Among a variety of induced pulmonary tumours, cystic squamous cell carcinomas were observed in five Syrian hamsters that inhaled a mixture of pyrolized tar pitch with coal oven flue exhaust (PCE) and additionally received intratracheal injections of benzo(a)pyrene. The histological appearance of these particular tumours is described, compared to similar tumour types in rats and the susceptibility of both species to inert particles is discussed.
Rittinghausen
S
S
Fraunhofer Institute of Toxicology and Aerosol Research, Department of Pathology, Hannover, Germany.
Dungworth
D L
DL
Dasenbrock
C
C
Ernst
H
H
Mohr
U
U
D000818:Animals; D001564:Benzo(a)pyrene / Q000633:toxicity*; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced* / Q000473:pathology; D003033:Coal Tar / Q000633:toxicity*; D006224:Cricetinae; D005260:Female; D005740:Gases; D007442:Intubation, Intratracheal; D008175:Lung Neoplasms / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D008647:Mesocricetus; D051381:Rats; D013045:Species Specificity
D005740:Gases; D001564:Benzo(a)pyrene; D003033:Coal Tar