title: [Current aspects of acute respiratory distress syndrome in children].
abstract: Acute respiratory distress syndrome (ARDS) is a frequent condition in pediatric intensive care units. The mortality remains high despite advances in conventional mechanical ventilation and aetiological treatment. Several animal studies have documented lung injury during mechanical ventilation with high tidal volume, and clinical investigations have shown that in human ARDS, most ventilation is distributed to the small areas of remaining aerated lung resulting in overdistension of these areas and lung injury ("baby lung" theory). Nevertheless the usefulness of extrapulmonary gas exchange remains much debated. New ventilatory strategies have been developed in order to reduce ventilator-induced lung injury and to improve systemic oxygenation but multicentric randomized clinical trials are needed before these strategies can be validated.
authors.affiliation: Unité de réanimation pédiatrique polyvalente, hôpital de Bicêtre, Le Kremlin-Bicêtre, France.
authors.forename: P
authors.initials: P
authors.lastname: Durand
authors.forename: C
authors.initials: C
authors.lastname: Le Pommelet
authors.forename: D
authors.initials: D
authors.lastname: Orbach
authors.forename: D
authors.initials: D
authors.lastname: Devictor
authors.forename: G
authors.initials: G
authors.lastname: Huault
mesh_terms: D000208:Acute Disease; D002245:Carbon Dioxide / Q000502:physiology; D002648:Child; D006801:Humans; D007231:Infant, Newborn; D010100:Oxygen / Q000502:physiology; D011379:Prognosis; D012121:Respiration, Artificial; D012127:Respiratory Distress Syndrome, Newborn / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology
chemical_list: D002245:Carbon Dioxide; D010100:Oxygen
vernacular_title: Aspects actuels du syndrome de détresse respiratoire aiguë de l'enfant.