Absence of rebound effect with calcium carbonate.
This was an open, randomised balance cross-over study in 12 healthy male volunteers. The antacid activity of calcium carbonate plus magnesium carbonate (Rennie and hydrotalcite (Talcid), given in the recommended dose of 2 tablets 4 times daily, were compared using 24 h intragastric measurement of pH. The volunteers received 2 tablets of calcium carbonate plus magnesium carbonate or hydrotalcite according to a randomised order 1 h after each meal and at bedtime. Results showed that both treatments have similar antacid efficacy and a similar duration of action of about one hour. There was no evidence of acid 'rebound' following either treatment during the second and third hours following the administration of antacid.
Simoneau
G
G
Clinique Thérapeutique, Hôpital Lariboisière, Paris, France.
D000328:Adult; D000863:Antacids / Q000494:pharmacology*; D002118:Calcium / Q000097:blood; D002119:Calcium Carbonate / Q000494:pharmacology*; D018592:Cross-Over Studies; D005744:Gastric Acid / Q000378:metabolism; D005753:Gastric Mucosa / Q000187:drug effects* / Q000378:metabolism; D005755:Gastrins / Q000097:blood; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008274:Magnesium / Q000494:pharmacology*; D008297:Male
D000863:Antacids; D005755:Gastrins; C005479:magnesium carbonate; D002119:Calcium Carbonate; D008274:Magnesium; D002118:Calcium