title: Cutting complexity down to size.
abstract: The proteasome is the most complex eukaryotic macromolecular assembly yet seen in fine detail. The structure reveals completely unexpected mechanisms by which the proteasome neatly chops up unwanted proteins for disposal or display to the immune system.
authors.forename: D I
authors.initials: DI
authors.lastname: Stuart
authors.forename: E Y
authors.initials: EY
authors.lastname: Jones
mesh_terms: D001105:Archaea / Q000737:chemistry / Q000201:enzymology; D001665:Binding Sites; D003546:Cysteine Endopeptidases / Q000737:chemistry* / Q000378:metabolism; D015394:Molecular Structure; D009097:Multienzyme Complexes / Q000737:chemistry* / Q000378:metabolism; D046988:Proteasome Endopeptidase Complex; D011487:Protein Conformation; D011506:Proteins / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000737:chemistry
chemical_list: D009097:Multienzyme Complexes; D011506:Proteins; D003546:Cysteine Endopeptidases; D046988:Proteasome Endopeptidase Complex