[Screening for congenital toxoplasmosis: pregnancy outcome after prenatal diagnosis in 211 cases].
OBJECTIVE
To emphasize the importance of follow-up after birth of infants with an antenatal diagnosis of congenital toxoplasmosis.


METHODS
Retrospective study from July 1987 through January 31 1995 on 211 women (214 fetuses) who had undergone ovular biopsy for toxoplasmosis seroconversion during pregnancy.


RESULTS
Antenatal diagnosis was positive in 13 patients (6.2%). Four pregnancies were terminated during the second trimester. Delivery was triggered at 37 weeks gestation in one woman and in 8 others pregnancy was continued with Fansidar. All infants were born live with infraclinic disease. Two fetal deaths related to biopsy technique occurred (0.95%) and one pregnancy was terminated before the results had been obtained. Only 21.3% of the patients were delivered in our unit. A total of 197 infants were delivered with a negative antenatal diagnosis: 93 were healthy, 5 had congenital toxoplasmosis, 1 died at 3 months and 98 had no or incomplete follow-up.


CONCLUSIONS
Incomplete post-natal follow-up is in contradiction with the excellent performance of antenatal diagnosis of congenital toxoplasmosis. Greater care is needed, especially since now only an amniocentisis is required to detect the parasite genome with polymerase chain reaction.
Abboud
P
P
Service de Gynécologie-Obstétrique, CHU de Reims, Hôpital Maison Blanche.
Villena
I
I
Chemla
C
C
Leroux
B
B
Talmuld
M
M
Bednarczyk
L
L
Pinon
J M
JM
Quéreux
C
C
D000293:Adolescent; D000328:Adult; D001706:Biopsy / Q000009:adverse effects / Q000379:methods; D005260:Female; D006801:Humans; D008403:Mass Screening / Q000379:methods; D010053:Ovary / Q000469:parasitology*; D011247:Pregnancy; D011256:Pregnancy Outcome; D011296:Prenatal Diagnosis / Q000379:methods*; D012189:Retrospective Studies; D014125:Toxoplasmosis, Congenital / Q000469:parasitology / Q000517:prevention & control*
Dépistage de la toxoplasmose congénitale: devenir des grossesses après le diagnostic anténatal. A propos de 211 cas.