Anticomplement activity of lysine complexes of propolis phenolic constituents and their synthetic analogs.
Several phenolic constituents of propolis and their synthetic analogs were derivatized with L-lysine. The ability of these complexes to alter complement activity was estimated in vitro in human serum. The influence of selected complexes on C3 hemolytic activity via classical pathway (CP) and alternative pathway (AP) and on zymosan-induced AP activation was determined. The results suppose that the anticomplement effect of the complexes might be related to the interaction with C3 complement component.
Georgieva
P
P
Bulgarian Academy of Sciences, Institute of Microbiology, Sofia, Bulgaria.
Ivanovska
N
N
Bankova
V
V
Popov
S
S
D003169:Complement Inactivator Proteins / Q000494:pharmacology*; D003170:Complement Pathway, Alternative / Q000187:drug effects*; D003171:Complement Pathway, Classical / Q000187:drug effects*; D004952:Esters; D044950:Flavanones; D005419:Flavonoids / Q000494:pharmacology; D006461:Hemolysis / Q000187:drug effects*; D006801:Humans; D008239:Lysine; D010636:Phenols / Q000494:pharmacology*; D011429:Propolis / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D015054:Zymosan / Q000494:pharmacology
D003169:Complement Inactivator Proteins; D004952:Esters; D044950:Flavanones; D005419:Flavonoids; D010636:Phenols; D011429:Propolis; D015054:Zymosan; D008239:Lysine; C028610:flavanone