Methotrexate pneumonitis after systemic treatment for ectopic pregnancy.
Pneumonitis is an infrequent complication of methotrexate therapy. Described is a case of pneumonitis after treatment of an ectopic pregnancy. A 20-year-old white woman, gravida 3, para 0, ectopic pregnancy 2, was treated for her third ectopic pregnancy with 88 mg (50 mg/m2) of intramuscular methotrexate. Four days later acute dyspnea, tachypnea, fever, patchy infiltrates on chest x-ray films, and a PO2 of 30 mm Hg developed. Respiratory distress resolved over 48 hours. Pneumonitis should be suspected in any patient treated with methotrexate who has unexplained dyspnea.
Horrigan
T J
TJ
Department of Obstetrics and Gynecology, Medical College of Ohio, Toledo 43699-0008, USA.
Fanning
J
J
Marcotte
M P
MP
D000328:Adult; D005260:Female; D006801:Humans; D008727:Methotrexate / Q000009:adverse effects*; D011014:Pneumonia / Q000139:chemically induced*; D011247:Pregnancy; D011274:Pregnancy, Tubal / Q000188:drug therapy*; D012422:Rupture, Spontaneous
D008727:Methotrexate