title: Can misoprostol and omeprazole reduce nicotine and ethanol induced gastric mucosal injury? A quantitative macroscopic and microscopic analysis in rats.
abstract: We compared the effects of misoprostol, omeprazole and methylcellulose (control) on gastric mucosal injury induced by nicotine and/or ethanol. The results demonstrate that misoprostol and omeprazole each significantly reduce macroscopic injury and deep injury at a microscopic level (P < 0.05) induced by nicotine alone, ethanol alone or a combination of ethanol and nicotine. Misoprostol and omeprazole each reduced the leakage of fluorescein isothiocyanate-albumin into the interstitium in the gastric mucosa. Misoprostol and omeprazole are each effective in preventing injury induced by nicotine and ethanol and vascular factors are involved.
authors.affiliation: Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong.
authors.forename: W M
authors.initials: WM
authors.lastname: Hui
authors.forename: J
authors.initials: J
authors.lastname: Ho
authors.forename: B W
authors.initials: BW
authors.lastname: Chen
authors.forename: C H
authors.initials: CH
authors.lastname: Cho
authors.forename: F J
authors.initials: FJ
authors.lastname: Branicki
authors.forename: S K
authors.initials: SK
authors.lastname: Lam
mesh_terms: D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D000431:Ethanol / Q000009:adverse effects*; D016650:Fluorescein-5-isothiocyanate; D005456:Fluorescent Dyes; D005753:Gastric Mucosa / Q000187:drug effects*; D008297:Male; D016595:Misoprostol / Q000494:pharmacology*; D009538:Nicotine / Q000009:adverse effects*; D009853:Omeprazole / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000897:Anti-Ulcer Agents; D005456:Fluorescent Dyes; D016595:Misoprostol; D000431:Ethanol; D009538:Nicotine; D016650:Fluorescein-5-isothiocyanate; D009853:Omeprazole