Endotoxin shock-associated hypothermia. How and why does it occur?
In sum, our results indicate that LPS shock-associated hypothermia involves the following major mechanisms: 1) a decrease in the threshold Tb for activation of cold thermogenesis; 2) the resultant widening of the interthreshold zone; and 3) cold-seeking behavior. We speculate that, in severe systemic inflammation, this hypothermia constitutes an adaptive response.
Romanovsky
A A
AA
Department of Physiology, University of Kanazawa Medical School, Japan. romanovs@ohsu.edu
Shido
O
O
Sakurada
S
S
Sugimoto
N
N
Nagasaka
T
T
D000818:Animals; D001794:Blood Pressure; D001833:Body Temperature Regulation / Q000187:drug effects; D007031:Hypothalamus / Q000502:physiology; D007035:Hypothermia / Q000209:etiology*; D008070:Lipopolysaccharides / Q000633:toxicity; D010101:Oxygen Consumption; D051381:Rats; D017208:Rats, Wistar; D012772:Shock, Septic / Q000503:physiopathology*; D012867:Skin / Q000098:blood supply; D014664:Vasodilation
D008070:Lipopolysaccharides