An increased gamma delta T cell population in the intestine of thymus-leukemia antigen transgenic mice.
In an approach to study thymic leukemia antigen's (TL's) function, we have developed transgenic mice that express T18d on virtually all somatic cells; in such mice, we initially observed changes in T cells within the thymus and lymph nodes as well as the ability of TL to undergo recognition by splenic T cells. As phase II of our study, we now present the results on the composition of gut T cell populations which may be a better measure of TL's true function. We have demonstrated an increase in the number of gamma delta T cells as well as the increase in gamma delta T cells expressing the V gamma 2 chain. These cells appear to be both CD4 and CD8 negative. This suggests that TL may select for a subset of gamma delta T cells within the gut and bolsters earlier reports implicating an H-2T regional gene product as the major histocompatibility complex ligand for gamma delta T cells.
Sharma
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P
Department of Microbiology, Pennsylvania State University College of Medicine, Hershey 17033, USA.
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M J
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Poritz
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Koltun
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Chorney
M J
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D000818:Animals; D000957:Antigens, Viral, Tumor / Q000235:genetics / Q000276:immunology; D002454:Cell Differentiation / Q000276:immunology; D004847:Epithelial Cells; D004848:Epithelium / Q000276:immunology; D005434:Flow Cytometry; D007421:Intestine, Small / Q000166:cytology / Q000276:immunology*; D008213:Lymphocyte Activation; D008562:Membrane Glycoproteins / Q000235:genetics* / Q000276:immunology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000032:analysis*; D016176:T-Lymphocyte Subsets / Q000166:cytology / Q000276:immunology*
D000957:Antigens, Viral, Tumor; D008562:Membrane Glycoproteins; D016692:Receptors, Antigen, T-Cell, gamma-delta; C028388:thymus-leukemia antigens