title: Retinal nerve fiber layer changes and visual field loss in idiopathic intracranial hypertension.
abstract: OBJECTIVE
  The authors retrospectively analyzed changes in the retinal nerve fiber layer in patients with idiopathic intracranial hypertension and studied their relation to visual field loss to determine the clinical usefulness of retinal nerve fiber analysis in the clinical management of patients with papilledema.
  
  
  METHODS
  Retinal nerve fiber layer photographs and visual fields from 36 eyes of 21 patients with papilledema due to idiopathic intracranial hypertension were analyzed for abnormalities in a masked fashion.
  
  
  RESULTS
  Nerve fiber layer changes were found in 67% of eyes studied. Superior areas within the nerve fiber layer were affected 5.4 times more frequently than inferior regions. Visual field loss was more prevalent in eyes with diffuse nerve fiber layer loss (89%) than in eyes with slit defects (29%). The location of the nerve fiber layer changes correlated with corresponding areas of visual field loss. Nerve fiber layer changes were as common in mild to moderate as in atrophic papilledema; however, slit defects predominated in patients with mild to moderate papilledema, and diffuse loss predominated in atrophic papilledema.
  
  
  CONCLUSIONS
  Changes in the retinal nerve fiber layer observed in patients with idiopathic intracranial hypertension provide objective information regarding the status of their optic nerve and may improve their clinical management.
authors.affiliation: Department of Ophthalmology, Tufts University-New England Eye Center, Boston, MA, USA.
authors.forename: T R
authors.initials: TR
authors.lastname: Hedges
authors.forename: R H
authors.initials: RH
authors.lastname: Legge
authors.forename: E
authors.initials: E
authors.lastname: Peli
authors.forename: C J
authors.initials: CJ
authors.lastname: Yardley
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D005451:Fluorescein Angiography; D005654:Fundus Oculi; D006801:Humans; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology*; D009900:Optic Nerve / Q000473:pathology*; D010211:Papilledema / Q000209:etiology; D010781:Photography; D011559:Pseudotumor Cerebri / Q000150:complications*; D012160:Retina / Q000473:pathology*; D012189:Retrospective Studies; D014786:Vision Disorders / Q000209:etiology / Q000473:pathology*; D058609:Visual Field Tests; D014794:Visual Fields