title: Aggressive, socially disruptive and antisocial behaviour associated with fronto-temporal dementia.
abstract: BACKGROUND
  Research suggests an association between frontal and temporal injury and antisocial conduct. We studied the frequency of antisocial behaviours in fronto-temporal dementia (FTD) where pathology is anterior frontal-temporal, compared with Alzheimer's disease (AD) where pathology is primarily posterior temporal-parietal.
  
  
  METHODS
  The presence of antisocial conduct was compared in 22 FTD versus 22 AD subjects. All FTD patients had anterior frontal or temporal hypoperfusion with single photon emission computed tomography, whereas those with AD had posterior temporal-parietal hypoperfusion.
  
  
  RESULTS
  Ten FTD and one AD subject showed antisocial behaviours, which included assault, indecent exposure, shoplifting and hit-and-run driving. Three FTD subjects were arrested. This difference was highly significant (P = 0.004).
  
  
  CONCLUSIONS
  Degeneration of frontal and temporal lobes predisposes to antisocial behaviour. This study supports a relationship between frontal-temporal dysfunction and certain types of antisocial activities.
authors.affiliation: UCLA School of Medicine, USA.
authors.forename: B L
authors.initials: BL
authors.lastname: Miller
authors.forename: A
authors.initials: A
authors.lastname: Darby
authors.forename: D F
authors.initials: DF
authors.lastname: Benson
authors.forename: J L
authors.initials: JL
authors.lastname: Cummings
authors.forename: M H
authors.initials: MH
authors.lastname: Miller
mesh_terms: D000374:Aggression; D000544:Alzheimer Disease / Q000150:complications / Q000000981:diagnostic imaging; D000987:Antisocial Personality Disorder / Q000000981:diagnostic imaging / Q000523:psychology*; D003704:Dementia / Q000150:complications* / Q000000981:diagnostic imaging; D006801:Humans; D008297:Male; D008875:Middle Aged; D015609:Organotechnetium Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime; D015899:Tomography, Emission-Computed, Single-Photon; D014980:Xenon Radioisotopes
chemical_list: D015609:Organotechnetium Compounds; D010091:Oximes; D014980:Xenon Radioisotopes; D019690:Technetium Tc 99m Exametazime