[Synthesis and antibacterial properties of pyrido[2,3-b]pyrazine derivatives].
Novel pyrido[2,3-b]pyrazine 1,4-dioxide and pyrido [2,3-b]pyrazine 1-oxide derivatives were synthesized from furazano [4,5-b]pyridine 3-oxide and the enolic form of 1,3-diketones or beta-ketoesters catalyzed by silica gel or molecular sieves. Their antibacterial activities were evaluated. As the results of anti-bacterial screening tests in vitro, pyrido[2,3-b]pyrazine 1,4-dioxide derivatives revealed strong activities, but pyrido[2,3-b]pyrazine 1-oxide derivatives revealed no activities.
Miyazawa
T
T
College of Pharmacy, Nihon University, Chiba, Japan.
Takabatake
T
T
Hasegawa
M
M
D000900:Anti-Bacterial Agents / Q000009:adverse effects / Q000138:chemical synthesis / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D004352:Drug Resistance, Microbial; D011719:Pyrazines / Q000138:chemical synthesis* / Q000494:pharmacology; D011725:Pyridines / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D011719:Pyrazines; D011725:Pyridines