[Age differences in topic concentrations and activity of H2- and B2-receptors in the larynx and trachea].
H2- and B2-receptors concentrations and activity were measured in 12 adult (6-7-month-old) and 12 young (1.5-2-month-old) rabbits by vascular reactions to histamine and bradykinin with and without prior usage of relevant specific receptor blocker. The findings suggest that concentration and activity of H2- and B2-receptors in young animals are the highest in the larynx. In mature animals-partially in trachea. With aging these concentrations and activity diminish in the larynx and rise in the trachea, the changes of B2-receptors are more significant.
Aslanian
G G
GG
NII of Pediatrics and Pediatric Surgery MZ RF, Moscow.
D000367:Age Factors; D000375:Aging / Q000378:metabolism*; D000818:Animals; D065168:Bradykinin Receptor Antagonists; D006635:Histamine H2 Antagonists / Q000494:pharmacology; D000960:Hypolipidemic Agents / Q000494:pharmacology; D007830:Larynx / Q000098:blood supply / Q000187:drug effects / Q000378:metabolism*; D008785:Metiamide / Q000494:pharmacology; D008833:Microcirculation / Q000187:drug effects / Q000502:physiology; D011727:Pyridinolcarbamate / Q000494:pharmacology; D011817:Rabbits; D018002:Receptors, Bradykinin / Q000378:metabolism*; D011970:Receptors, Histamine H2 / Q000187:drug effects / Q000378:metabolism*; D014132:Trachea / Q000098:blood supply / Q000187:drug effects / Q000378:metabolism*
D065168:Bradykinin Receptor Antagonists; D006635:Histamine H2 Antagonists; D000960:Hypolipidemic Agents; D018002:Receptors, Bradykinin; D011970:Receptors, Histamine H2; D008785:Metiamide; D011727:Pyridinolcarbamate
Vozrastnye razlichiia topicheskoi kontsentratsii i aktivnosti H2- i B2-retseptorov v gortani i trakhee.