title: [Measles vaccination by the aerosol method in Mexico].
abstract: The present work describes the anti-measles vaccination program by the inhaled aerosol method undertaken in Mexico between 1988 and 1990. Detailed descriptions are given of the equipment, staff, training programs, promotion and campaigns. The vaccine is specified: Edmonston-Zagreb strain cultured in diploid cells at the Instituto Nacional de Virología of the Secretaría de Salud in Mexico with titres varying from 1045 plaque forming units (PFU/ml) to 1048 PFU/ml administered in a 30 sec inhalation with aerosol. During this exposure period, 2800 to 4000 PFU per child are estimated to enter the child, of which approximately 25% is the retained doses, i.e. 700 to 1000 PFU/child. A total of 3760684 children of school and pre-school age have been vaccinated in 13 of the 32 federal entities of the country. No undesirable effects of any importance were observed, and the limited serological and field studies support the effectiveness and security of this method. On the other hand, the method is much cheaper, faster and better accepted by the population than the subcutaneous injection.
authors.affiliation: Academia Nacional de Medicina, México.
authors.forename: J
authors.initials: J
authors.lastname: Fernández-de Castro
authors.forename: J
authors.initials: J
authors.lastname: Kumate-Rodríguez
authors.forename: J
authors.initials: J
authors.lastname: Sepúlveda
authors.forename: J M
authors.initials: JM
authors.lastname: Ramírez-Isunza
authors.forename: J L
authors.initials: JL
authors.lastname: Valdespino-Gómez
mesh_terms: D000336:Aerosols; D002648:Child; D002675:Child, Preschool; D005069:Evaluation Studies as Topic; D006801:Humans; D007223:Infant; D008457:Measles / Q000517:prevention & control*; D008458:Measles Vaccine / Q000008:administration & dosage*; D008800:Mexico; D014611:Vaccination / Q000379:methods*
chemical_list: D000336:Aerosols; D008458:Measles Vaccine
vernacular_title: La vacunación antisarampionosa en México por el método de aerosol.