title: Eccrine syringofibroadenoma surrounding a squamous cell carcinoma: a case report.
abstract: A 91-year-old man presented with a 9.0 x 7.0 cm exophytic mass on the dorsum of the right foot, surrounded by a scaling hyperkeratotic plaque-like lesion that had been present for many years. He had similar long-standing hyperkeratotic plaque-like lesions on both legs. Histopathologic examination of the exophytic mass revealed a well-differentiated squamous cell carcinoma surrounded by an eccrine syringofibroadenoma (ESFA). Histochemistry, immunohistochemistry and electron microscopy support this diagnosis. To our knowledge, this is the only reported case of ESFA being intimately associated with a malignant neoplasm.
authors.affiliation: Department of Pathology, State University of New York Health Science Center at Brooklyn 11203, USA.
authors.forename: S M
authors.initials: SM
authors.lastname: Lele
authors.forename: E S
authors.initials: ES
authors.lastname: Gloster
authors.forename: E R
authors.initials: ER
authors.lastname: Heilman
authors.forename: P C
authors.initials: PC
authors.lastname: Chen
authors.forename: C K
authors.initials: CK
authors.lastname: Chen
authors.forename: A P
authors.initials: AP
authors.lastname: Anzil
authors.forename: J N
authors.initials: JN
authors.lastname: Pozner
authors.forename: M J
authors.initials: MJ
authors.lastname: Reardon
mesh_terms: D006607:Adenoma, Sweat Gland / Q000473:pathology* / Q000648:ultrastructure; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000473:pathology* / Q000648:ultrastructure; D018226:Fibroadenoma / Q000473:pathology* / Q000648:ultrastructure; D005534:Foot Diseases / Q000473:pathology*; D006801:Humans; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000473:pathology* / Q000648:ultrastructure; D013544:Sweat Gland Neoplasms / Q000473:pathology* / Q000648:ultrastructure