HSP70-Hom NcoI polymorphism and HLA-associations in the Finnish population and in patients with ankylosing spondylitis or reactive arthritis.
The NcoI polymorphism of the HSP70-Hom gene was investigated in the Finnish population and in two HLA-B27-associated autoimmune diseases. The two HSP70-Hom alleles were shown to be strongly associated to some specific HLA-B/DR haplotypes in random Finnish population and the segregation of the alleles as a part of these haplotypes was confirmed in 18 families. In addition, the HSP70-Hom alleles of 31 patients with ankylosing spondylitis (AS) and 38 with reactive arthritis (ReA) were compared with each other and with 56 unrelated healthy HLA-B27 positive individuals. The results indicated that the HSP70-Hom polymorphic variation is not connected independently to the different pathogenesis of AS and ReA, as no statistically significant differences between the patient groups and/or controls could be found. The HSP70-Hom status was investigated also in 28 homozygous HLA typing cells and when compared with previously published results of HSP70-l and HSP70-2 polymorphisms, it appeared that these three MHC Class-III linked HSP70 genes segregated in fixed allelic combinations.
Westman
P
P
Tissue Typing Laboratory, Finnish Red Cross Blood Transfusion Service, Helsinki, Finland.
Partanen
J
J
Leirisalo-Repo
M
M
Koskimies
S
S
D016918:Arthritis, Reactive / Q000235:genetics* / Q000276:immunology; D002460:Cell Line; D015252:Deoxyribonucleases, Type II Site-Specific / Q000378:metabolism; D005387:Finland; D006680:HLA Antigens / Q000235:genetics*; D015796:HLA-B27 Antigen / Q000235:genetics; D018840:HSP70 Heat-Shock Proteins / Q000235:genetics*; D006720:Homozygote; D006801:Humans; D011110:Polymorphism, Genetic; D000091402:Prohibitins; D013167:Spondylitis, Ankylosing / Q000235:genetics* / Q000276:immunology
D006680:HLA Antigens; D015796:HLA-B27 Antigen; D018840:HSP70 Heat-Shock Proteins; C000717331:PHB2 protein, human; D000091402:Prohibitins; C052380:endodeoxyribonuclease NcoI; D015252:Deoxyribonucleases, Type II Site-Specific