Nutrient intake and blood pressure in the Dietary Intervention Study in Children.
Delineating the role that diet plays in blood pressure levels in children is important for guiding dietary recommendations for the prevention of hypertension. The purpose of this study was to investigate relationships between dietary nutrients and blood pressure in children. Data were analyzed from 662 participants in the Dietary Intervention Study in Children who had elevated low-density lipoprotein cholesterol and were aged 8 to 11 years at baseline. Three 24-hour dietary recalls, systolic pressure, diastolic pressure, height, and weight were obtained at baseline, 1 year, and 3 years. Nutrients analyzed were the micronutrients calcium, magnesium, and potassium; the macronutrients protein, carbohydrates, total fat, saturated fat, polyunsaturated fat, and monounsaturated fat; dietary cholesterol; and total dietary fiber. Baseline and 3-year longitudinal relationships were examined through multivariate models on diastolic and systolic pressures separately, controlling for height, weight, sex, and total caloric intake. The following associations were found in longitudinal analyses: analyzing each nutrient separately, for systolic pressure, inverse associations with calcium (P < .05); magnesium, potassium, and protein (all P < .01); and fiber (P < .05), and direct associations with total fat and monounsaturated fat (both P < .05); for diastolic pressure, inverse associations with calcium (P < .01); magnesium and potassium (both P < .05), protein (P < .01); and carbohydrates and fiber (both P < .05), and direct associations with polyunsaturated fat (P < .01) and monounsaturated fat (P < .05). Analyzing all nutrients simultaneously, for systolic pressure, direct association with total fat (P < .01); for diastolic pressure, inverse associations with calcium (P < .01) and fiber (P < .05), and direct association with total and monounsaturated fats (both P < .05). Results from this sample of children with elevated low-density lipoprotein cholesterol indicate that dietary calcium, fiber, and fat may be important determinants of blood pressure level in children.
Simons-Morton
D G
DG
Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, Bethesda, MD 20892-7936, USA. simonsd@gwgate.nhlbi.nlh.gov
Hunsberger
S A
SA
Van Horn
L
L
Barton
B A
BA
Robson
A M
AM
McMahon
R P
RP
Muhonen
L E
LE
Kwiterovich
P O
PO
Lasser
N L
NL
Kimm
S Y
SY
Greenlick
M R
MR
D000367:Age Factors; D001794:Blood Pressure; D002648:Child; D002664:Child Nutritional Physiological Phenomena; D008078:Cholesterol, LDL / Q000097:blood; D003627:Data Interpretation, Statistical; D003971:Diastole; D004032:Diet; D002149:Energy Intake; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D012737:Sex Factors; D013599:Systole; D013997:Time Factors; D014131:Trace Elements / Q000008:administration & dosage
D008078:Cholesterol, LDL; D014131:Trace Elements