Anti-M and anti-N reactivity with Tn and T activated cells.
Monoclonal (MoAB) anti-N and anti-M were tested against normal, T-activated, and Tn-activated RBCs. In vivo T and Tn activation affects the sialic acid expression on the RBCs which may affect the binding of antibodies to the M and/or N antigens. The majority of MoAB anti-M and anti-N in this workshop demonstrated some effect from in vivo T and Tn activation.
Harris
T
T
Pacific Northwest Region-American Red Cross, Portland, OR 97227, USA.
Lukasavage
T
T
D000937:Antigen-Antibody Reactions / Q000276:immunology*; D002236:Carbohydrate Conformation; D004912:Erythrocytes / Q000737:chemistry / Q000276:immunology*; D005690:Galactose / Q000737:chemistry*; D006801:Humans; D007519:Isoantigens / Q000276:immunology*; D008951:MNSs Blood-Group System / Q000276:immunology*; D009154:Mutation; D019158:N-Acetylneuraminic Acid / Q000737:chemistry*
D007519:Isoantigens; D008951:MNSs Blood-Group System; D019158:N-Acetylneuraminic Acid; D005690:Galactose