[The evaluation of the efficacy of immunization against plague by the modulation in the index of the macrophagal transformation of of the peripheral blood monocytes].
The subcutaneous and aerogenous immunization of experimental animals with live dried antiplague vaccine has been shown to modulate the macrophagal transformation index of peripheral blood monocytes (PBM) which correlates with the resistance of the animals to the causative agent of plague. This finding allows to recommend the use of PBM for the evaluation of the effectiveness of immunization with antiplague vaccine.
Verkina
L M
LM
Vasil'eva
G I
GI
Kiseleva
A K
AK
Moskalenko
V I
VI
D000280:Administration, Inhalation; D000818:Animals; D004353:Drug Evaluation, Preclinical; D006168:Guinea Pigs; D007114:Immunization / Q000379:methods; D007279:Injections, Subcutaneous; D008262:Macrophage Activation / Q000187:drug effects* / Q000276:immunology; D009000:Monocytes / Q000187:drug effects* / Q000276:immunology; D010930:Plague / Q000276:immunology / Q000517:prevention & control*; D010931:Plague Vaccine / Q000008:administration & dosage / Q000276:immunology*; D013997:Time Factors; D014613:Vaccines, Attenuated / Q000008:administration & dosage / Q000276:immunology
D010931:Plague Vaccine; D014613:Vaccines, Attenuated
Otsenka éffektivnosti immunizatsii protiv chumy po moduliatsii pokazatelia makrofagal'noĭ transformatsii monotsitov perifericheskoĭ krovi.