The actions of ondansetron and dexamethasone to antagonise cisplatin-induced emesis in the ferret.
The ability of ondansetron and dexamethasone to antagonise cisplatin 10 mg/kg i.p. induced emesis was investigated in the ferret during a 24 h period. Ondansetron 0.5-5 mg/kg, as a single injection, effectively antagonised the response for approximately 4 h and revealed a subsequent response that was sensitive to further ondansetron treatment. The three times per day administration of dexamethasone 1 mg/kg i.p. alone or combined with ondansetron 1 mg/kg i.p. significantly reduced the vomiting response by 49 and 79%, respectively. The results are discussed in terms of their relevance to acute and delayed emesis in man.
Rudd
J A
JA
Department of Pharmacology, Faculty of Medicine, Chinese University of Hong Kong, Shatin. JAR@cuhk.edu.hk
Naylor
R J
RJ
D000818:Animals; D000932:Antiemetics / Q000627:therapeutic use*; D000970:Antineoplastic Agents; D001522:Behavior, Animal / Q000187:drug effects; D002945:Cisplatin; D003907:Dexamethasone / Q000627:therapeutic use*; D005289:Ferrets / Q000502:physiology*; D008297:Male; D017294:Ondansetron / Q000627:therapeutic use*; D014839:Vomiting / Q000139:chemically induced / Q000517:prevention & control*
D000932:Antiemetics; D000970:Antineoplastic Agents; D017294:Ondansetron; D003907:Dexamethasone; D002945:Cisplatin