title: A glucose-sensing polymer.
abstract: We have prepared a robust polymer that can be used to measure glucose concentrations in complex biological media. At alkaline pH, the metal-complexing polymer binds glucose and instantly releases protons in proportion to the glucose concentration over a clinically relevant range (0 to 25 mM). The inexpensive polymer is sufficiently selective to provide an easily measurable response to glucose in porcine plasma. The polymer's ability to function at nonphysiological pH (at which the buffer capacity of biological samples is small) makes it possible to design simple and inexpensive sensing devices based on measurement of changes in proton concentration.
authors.affiliation: Division of Chemistry and Chemical Engineering 210-41, California Institute of Technology, Pasadena 91125, USA.
authors.forename: G
authors.initials: G
authors.lastname: Chen
authors.forename: Z
authors.initials: Z
authors.lastname: Guan
authors.forename: C T
authors.initials: CT
authors.lastname: Chen
authors.forename: L
authors.initials: L
authors.lastname: Fu
authors.forename: V
authors.initials: V
authors.lastname: Sundaresan
authors.forename: F H
authors.initials: FH
authors.lastname: Arnold
mesh_terms: D000818:Animals; D015374:Biosensing Techniques; D001709:Biotechnology; D001786:Blood Glucose / Q000032:analysis*; D015190:Blood Glucose Self-Monitoring / Q000379:methods; D003300:Copper; D003922:Diabetes Mellitus, Type 1 / Q000097:blood; D006571:Heterocyclic Compounds; D006801:Humans; D006863:Hydrogen-Ion Concentration; D011108:Polymers; D011522:Protons; D013552:Swine
chemical_list: D001786:Blood Glucose; D006571:Heterocyclic Compounds; D011108:Polymers; D011522:Protons; C075712:1,4,7-triazacyclononane; D003300:Copper