title: Race and survival from breast cancer: based on Cancer and Leukemia Group B trial 8541.
abstract: OBJECTIVE
  The purpose of this research was to evaluate the prognostic significance of race and survival in stage II breast cancer among women treated with adjuvant chemotherapy in the Cancer and Leukemia Group B (CALGB) trial 8541.
  
  
  METHODS
  A total of 1572 patients with node-positive breast cancer were entered in CALGB trial 8541. This study opened in January 1985 and randomized patients to receive "high-dose," "standard-dose," or "low-dose" adjuvant CAF (cyclophosphamide, doxorubicin, and fluorouracil) chemotherapy. Patients were stratified according to treatment of the primary lesion (mastectomy or breast conservation), menopausal status, number of positive lymph nodes, and estrogen-receptor status. Twelve percent of the patients entered in this study were African-American, 84% were white, and 4% were of other racial backgrounds.
  
  
  RESULTS
  African-Americans and whites were evenly distributed on all three arms. In a univariate analysis, African-Americans were more likely to have a reduced survival and shorter time to relapse than other patients. Race was moderately associated with tumor size, receptor status, and type of surgery. In a multivariate analysis, after adjusting for the dose of chemotherapy, number of lymph nodes, estrogen-receptor status, and age, race was no longer of prognostic significance.
  
  
  CONCLUSIONS
  After adjustment for other well-recognized prognostic factors, race appears to have no independent prognostic significance for survival from stage II breast cancer among women receiving adjuvant CAF chemotherapy.
authors.affiliation: Department of Radiation Oncology, University of California, San Francisco 94143-0226, USA.
authors.forename: M
authors.initials: M
authors.lastname: Roach
authors.forename: C
authors.initials: C
authors.lastname: Cirrincione
authors.forename: D
authors.initials: D
authors.lastname: Budman
authors.forename: D
authors.initials: D
authors.lastname: Hayes
authors.forename: D
authors.initials: D
authors.lastname: Berry
authors.forename: J
authors.initials: J
authors.lastname: Younger
authors.forename: R
authors.initials: R
authors.lastname: Hart
authors.forename: I C
authors.initials: IC
authors.lastname: Henderson
mesh_terms: D044383:Black People; D001943:Breast Neoplasms / Q000188:drug therapy / Q000208:ethnology* / Q000401:mortality* / Q000473:pathology; D017024:Chemotherapy, Adjuvant; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D009367:Neoplasm Staging; D011446:Prospective Studies; D012044:Regression Analysis; D044465:White People; D001741:Black or African American