title: The complete primary structure of Cw*1701 reveals a highly divergent HLA class I molecule.
abstract: Genotyping of the HLA-C locus by PCR-SSP has previously shown 100% association of B41 and B42 with a new allelic variant. Partial sequencing studies (exons 2-4) demonstrated that this PCR-SSP variant corresponded to the new allele Cw*1701. In this study we have characterized the whole coding region of Cw*1701 from a Bubi individual of Equatorial Guinea. Our results partially confirm the previously reported sequence and reveal that Cw*1701 has many new polymorphisms at several exons, including a 18-bp insertion in exon 5. Cw*1701 is thus a most unusual HLA-C molecule defining a third allelic lineage of this locus.
authors.affiliation: Servicio de Inmunología, Clínica Puerta de Híerro, Madrid, Spain.
authors.forename: M J
authors.initials: MJ
authors.lastname: Herrero
authors.forename: C
authors.initials: C
authors.lastname: Vilches
authors.forename: R
authors.initials: R
authors.lastname: de Pablo
authors.forename: S
authors.initials: S
authors.lastname: Puente
authors.forename: M
authors.initials: M
authors.lastname: Kreisler
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D018076:DNA, Complementary; D015236:HLA-C Antigens / Q000235:genetics*; D008969:Molecular Sequence Data; D017386:Sequence Homology, Amino Acid; D012689:Sequence Homology, Nucleic Acid
chemical_list: D018076:DNA, Complementary; D015236:HLA-C Antigens