[What are the criteria for choosing a model for evaluating arterial antithrombotic therapy?].
The use of models of experimental arterial thrombosis both in vivo and ex vivo in animals and ex vivo in humans is an obligatory step to the understanding of mechanisms involved in thrombogenesis as well as in the evaluation of anti-thrombotic therapeutics. Arterial thrombogenesis is a complex phenomenon which involves multiple systems, mechanisms and parameters. Therefore studies of thrombogenesis from a pathological as well as a therapeutic point are necessary for understanding this problem in its entirety. For these reasons, it is necessary to use models as representative as possible of the human pathological condition. Besides these theoretical requirements, practical needs have also to be fulfilled (accessibility of the models, adaptation to the type of the technique to different animal model and/or of the size of the animal to the amount of molecule available, cost ...) which necessary lead to some promises. In this review we have tried to underline the criteria for the choice, characteristics, advantages and disadvantages of the major models commonly accepted and used, in such a form that the reader who may not be an expert in the field would be led either to choose a particular model for a specific purpose or to appreciate a paper or a report based on an experimental model of arterial thrombosis. In vitro models of arterial thrombosis are so far removed from reality and due to their nature can generate so much artifacts thus we have omitted their discussion from this paper.
André
P
P
INSERM U353, hôpital Saint-Louis, Paris.
Bal dit Sollier
C
C
Bonneau
M
M
Pignaud
G
G
Hainaud
P
P
Azzam
K
K
Drouet
L
L
D000818:Animals; D001158:Arteries / Q000293:injuries; D001775:Blood Circulation; D003362:Cost-Benefit Analysis; D004195:Disease Models, Animal; D004285:Dogs; D004730:Endothelium, Vascular; D004992:Ethics, Medical; D005069:Evaluation Studies as Topic; D005343:Fibrinolytic Agents / Q000494:pharmacology*; D006168:Guinea Pigs; D006801:Humans; D011817:Rabbits; D051381:Rats; D015203:Reproducibility of Results; D013045:Species Specificity; D013927:Thrombosis / Q000503:physiopathology
D005343:Fibrinolytic Agents
Sur quels critères choisir un modèle pour évaluer une thérapeutique antithrombotique artérielle?