title: [Molecular biology markers of neuroblastoma as the basis for a therapy concept].
abstract: Molecular biological markers that influence prognosis should be considered in the optimization of therapy for disseminated forms of neuroblastoma. Some of these markers include: N-myc amplification, deletion of 1p36, ploidy, and trk expression. Neuroblastoma without N-myc amplification and high trk expression show a favorable outcome and would enable a more gentle chemotherapy treatment. Neuroblastomas with N-myc amplification and lack of trk expression behave extremely unfavorably and require an even more intensive treatment.
authors.affiliation: Klinikum Schnarrenberg, Abteilung Kinderchirurgie, Universität Tübingen.
authors.forename: R
authors.initials: R
authors.lastname: Girgert
authors.forename: J
authors.initials: J
authors.lastname: Treuner
authors.forename: P
authors.initials: P
authors.lastname: Schweizer
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000235:genetics*; D017024:Chemotherapy, Adjuvant; D002648:Child; D002869:Chromosome Aberrations / Q000235:genetics*; D003131:Combined Modality Therapy; D006801:Humans; D009367:Neoplasm Staging; D009447:Neuroblastoma / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology; D011379:Prognosis
chemical_list: D014408:Biomarkers, Tumor
vernacular_title: Molekularbiologische Merkmale des Neuroblastoms als Grundlage eines Therapiekonzepts.