title: Determinants of resting energy expenditure in obese non-diabetic caucasian women.
abstract: OBJECTIVE
  To investigate the determinants of resting energy expenditure (REE) in obese non-diabetic Caucasian women.
  
  
  METHODS
  A cross-sectional survey study before the beginning of a weight-reduction program.
  
  
  METHODS
  141 obese, non-diabetic women of Caucasian origin (BMI 34.8 +/- 3.7 kg/m2, age 43.2 +/- 8.0 y, mean +/- s.d.).
  
  
  METHODS
  Resting energy expenditure (an indirect calorimetry), body composition (a bioelectrical impedance), fat distribution (anthropometry) and heart rate (ECG) were determined after 12 h overnight fast and apolipoprotein E phenotype was examined.
  
  
  RESULTS
  In a linear multiple regression analysis fat-free mass, fat mass and age together with heart rate and waist-hip ratio emerged as significant determinants of REE. In the other regression model, also serum insulin emerged as a significant determinant of REE, in addition to fat-free mass, fat mass and age. There was no significant differences in REE among the different apolipoprotein E phenotype groups.
  
  
  CONCLUSIONS
  Besides fat-free mass, also fat mass, age, heart rate, waist-hip-ratio, and serum insulin level make a significant contribution to REE in obese women.
authors.affiliation: Department of Clinical Nutrition, University of Kuopio, Finland.
authors.forename: L
authors.initials: L
authors.lastname: Karhunen
authors.forename: A
authors.initials: A
authors.lastname: Franssila-Kallunki
authors.forename: A
authors.initials: A
authors.lastname: Rissanen
authors.forename: K
authors.initials: K
authors.lastname: Kervinen
authors.forename: Y A
authors.initials: YA
authors.lastname: Kesäniemi
authors.forename: M
authors.initials: M
authors.lastname: Uusitupa
mesh_terms: D000273:Adipose Tissue; D000328:Adult; D001057:Apolipoproteins E / Q000097:blood; D001823:Body Composition; D001824:Body Constitution; D002153:Calorimetry, Indirect; D003430:Cross-Sectional Studies; D017097:Electric Impedance; D004734:Energy Metabolism; D005260:Female; D006339:Heart Rate; D006801:Humans; D009765:Obesity / Q000378:metabolism*; D010641:Phenotype; D012044:Regression Analysis; D012146:Rest; D012907:Smoking
chemical_list: D001057:Apolipoproteins E