title: Immunoprophylaxis of group B respiratory syncytial virus infection in cotton rats.
abstract: Two antigenic groups of respiratory syncytial virus (RSV) have been identified: A (RSV/A) and B (RSV/B). Topical administration of human IgG screened for high titers of antibody to RSV/A (RSVIg) is protective against RSV/A infection in the cotton rat model. The study attempted to determine if topical RSVIg would also be protective against RSV/B. Cotton rats were pretreated intranasally with RSVIg or with monospecific antiserum obtained from animals previously infected with RSV/A or RSV/B (day 0), challenged intranasally with RSV/A or RSV/B (day 1), and sacrificed for virus titration (day 5). Cotton rat antiserum to RSV/B protected against RSV/A and RSV/B, while antiserum to RSV/A protected only against RSV/A. RSVIg, although prepared on the basis of activity against RSV/A, was also protective against RSV/B.
authors.affiliation: Department of Pediatrics, George Washington University School of Medicine and Health Sciences, Washington, DC, USA.
authors.forename: L A
authors.initials: LA
authors.lastname: Faverio
authors.forename: F M
authors.initials: FM
authors.lastname: Piazza
authors.forename: S A
authors.initials: SA
authors.lastname: Johnson
authors.forename: M E
authors.initials: ME
authors.lastname: Darnell
authors.forename: M G
authors.initials: MG
authors.lastname: Ottolini
authors.forename: V G
authors.initials: VG
authors.lastname: Hemming
authors.forename: G A
authors.initials: GA
authors.lastname: Prince
mesh_terms: D000818:Animals; D006801:Humans; D007106:Immune Sera / Q000276:immunology; D007074:Immunoglobulin G / Q000276:immunology; D018357:Respiratory Syncytial Virus Infections / Q000517:prevention & control*; D012136:Respiratory Syncytial Viruses / Q000276:immunology*; D016205:Sigmodontinae
chemical_list: D007106:Immune Sera; D007074:Immunoglobulin G