title: The significance of tumor necrosis factor (TNF) levels for rejection of joint allograft.
abstract: This paper describes the efficacy of utilizing Tumor Necrosis Factor-alpha (TNF) as a detectable parameter of acute rejection after bone allografts. The authors used a bone-joint allograft model, transferring vascularized allograft knee joints across a major histocompatibility barrier, using three groups of rats divided into controls, non-immunosuppressed, and immunosuppressed with cyclosporine. The paper supplies preliminary information suggesting that TNF may be a marker for early bone-joint allograft rejection.
authors.affiliation: Department of Orthopedic Surgery, Yamanashi Medical College, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Watanabe
authors.forename: K
authors.initials: K
authors.lastname: Nagasawa
authors.forename: Y
authors.initials: Y
authors.lastname: Hamada
authors.forename: T
authors.initials: T
authors.lastname: Toshima
authors.forename: Y
authors.initials: Y
authors.lastname: Sakano
authors.forename: N
authors.initials: N
authors.lastname: Akamatsu
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood; D016025:Bone Transplantation / Q000473:pathology; D016572:Cyclosporine / Q000627:therapeutic use; D006084:Graft Rejection / Q000097:blood* / Q000473:pathology; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007719:Knee Joint / Q000601:surgery*; D051381:Rats; D011914:Rats, Inbred BN; D011916:Rats, Inbred F344; D014184:Transplantation, Homologous; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D007166:Immunosuppressive Agents; D014409:Tumor Necrosis Factor-alpha; D016572:Cyclosporine