title: Acute supraglottitis in adults: early indicators of airway obstruction.
abstract: OBJECTIVE
  To show that cardinal signs of upper airway obstruction are characteristically absent in the early phases of potentially fatal supraglottitis.
  
  
  METHODS
  The hospital records of 9 previously healthy adults who died from autopsy-proven supraglottitis within 12 hours after sudden onset of severe sore throat.
  
  
  RESULTS
  Six patients who were discharged from the emergency room with a diagnosis of pharyngitis died at home within 4 hours after dismissal. Three patients suspected of supraglottitis were admitted and treated medically; by the time signs of respiratory obstruction appeared, attempts at airway intervention failed. None of the 9 patients presented with symptoms or signs of respiratory distress, but all gave a history of fulminant sore throat associated with chills and fever. In all patients, the pulse rate was above 100 per minute.
  
  
  CONCLUSIONS
  In the early phases of acute supraglottitis, the most reliable indicator of impending airway obstruction is a rapidly developing severe sore throat. Dyspnea, tachypnea, retractions, stridor, and cyanosis are manifestations of advanced stages of the infection and should not be awaited to determine the need for airway intervention.
authors.affiliation: Department of Otolaryngology, Head and Neck Surgery, Washington Hospital Center, DC 20010, USA.
authors.forename: Z E
authors.initials: ZE
authors.lastname: Deeb
mesh_terms: D000328:Adult; D000402:Airway Obstruction / Q000175:diagnosis* / Q000209:etiology / Q000401:mortality; D005931:Glottis; D006801:Humans; D007827:Laryngitis / Q000150:complications / Q000175:diagnosis* / Q000401:mortality; D008297:Male; D013997:Time Factors