Effect of inferior mesenteric artery ligation on the healing of colonic anastomoses in rats.
OBJECTIVE
To evaluate the healing of single-layer end-to-end colonic anastomoses in rats in which the inferior mesenteric artery had been ligated.


METHODS
Controlled experiment.


METHODS
Medical school, Poland.


METHODS
20, 2-month-old inbred Buffalo rats (n = 10 in each group).


METHODS
Laparotomy with ligation of the inferior mesenteric artery (laparotomy alone in the control group), followed by segmental colonic resection and primary anastomosis 24 hours later, and resection of the anastomosis 4 days later.


METHODS
Degree of contamination and inflammation of peritoneal cavity and histological evaluation of the anastomosis.


RESULTS
No animal died and no anastomosis leaked. There were no histological differences in the extent of early healing between the groups. In 2 animals in the experimental group pathogens were grown from the peritoneal culture (Escherichia coli and Bacteroides fragilis in each case).


CONCLUSIONS
High ligation of the inferior mesenteric artery had no deleterious effect on the healing of colonic anastomoses in rats.
Wojczys
R
R
1st Department of Surgery, University of Medicine, Wrocław, Poland.
Bednarz
W
W
D000714:Anastomosis, Surgical; D000818:Animals; D003106:Colon / Q000601:surgery*; D005260:Female; D008026:Ligation; D017537:Mesenteric Artery, Inferior / Q000601:surgery*; D051381:Rats; D011919:Rats, Inbred Strains; D014945:Wound Healing