title: Myocardial fluid balance in acute hypertension.
abstract: OBJECTIVE
  We hypothesized that (1) acute arterial hypertension increases myocardial microvascular fluid filtration and (2) the combination of acute arterial hypertension and coronary sinus pressure elevation may increase myocardial microvascular filtration sufficiently to estimate the osmotic reflection coefficient of the myocardial exchange vessels.
  
  
  METHODS
  In nine mechanically ventilated dogs we cannulated the prenodal major cardiac lymph trunk. With the use of central venous phenylephrine infusion, mean arterial pressure (MAP) was raised progressively to 120, 160, and 180 mm Hg. In five dogs we additionally raised coronary sinus pressure (CSP) to 20 and 40 mm Hg. At each manipulation of MAP and/or CSP, we measured indexes of myocardial lymphatic function and lymph-to-plasma concentration ratios for total protein (CL(TP)/CP(TP) and albumin (CL(alb)/CP(alb)).
  
  
  RESULTS
  Myocardial lymph flow rate (QL; microL/min) increased exponentially (QL = 10.9.e0.014.(MAP) and myocardial lymph driving pressure (PL; mm Hg) increased linearly (PL = 2.30 + 0.20 + 0.20 . MAP) following increases, whereas CL(TP)/CP(TP) and CL(alb)/CP(alb) decreases from 0.67 +/- 0.07 (SD) to 0.56 +/- 0.10 and from 0.91 +/- 0.05 to 0.75 +/- 0.11, respectively. Adding CSP elevation increased QL up to 12 times control associated with further CL(TP)/C(TP) and CL(alb)/CP(alb) decreases to 0.49 +/- 0.05 and 0.59 +/- 0.02, respectively.
  
  
  CONCLUSIONS
  We conclude that hypertensive arterial pressures are, at least in part, transmitted to the myocardial microvascular exchange vessels in the intact animal leading to increased microvascular fluid filtration. However, the combination of acute arterial hypertension and coronary sinus pressure elevation is not sufficient to produce filtration independence required for myocardial osmotic reflection coefficient determination.
authors.affiliation: Department of Anesthesiology, University of Texas Medical School, Houston 77030, USA.
authors.forename: U
authors.initials: U
authors.lastname: Mehlhorn
authors.forename: K L
authors.initials: KL
authors.lastname: Davis
authors.forename: G A
authors.initials: GA
authors.lastname: Laine
authors.forename: H J
authors.initials: HJ
authors.lastname: Geissler
authors.forename: S J
authors.initials: SJ
authors.lastname: Allen
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002404:Catheterization; D003331:Coronary Vessels / Q000503:physiopathology*; D004285:Dogs; D004487:Edema; D006321:Heart / Q000503:physiopathology*; D006439:Hemodynamics; D006973:Hypertension / Q000503:physiopathology*; D008196:Lymph / Q000502:physiology; D008297:Male; D008833:Microcirculation / Q000502:physiology; D010656:Phenylephrine / Q000494:pharmacology; D014882:Water-Electrolyte Balance / Q000502:physiology*
chemical_list: D010656:Phenylephrine