Plasticity of the hippocampal-prefrontal cortex synapses.
This paper summarizes experiments showing that the direct excitatory glutamergic pathway projecting from area CA1 and subiculum to the prefrontal cortex in the rat express a long-lasting NMDA receptor-dependent form of LTP that can be induced for several days in the freely-moving rat. Other experiments examined its functional significance in learning and the role of dopamine in the regulation of hippocampal-prefrontal cortex plasticity.
Jay
T M
TM
Laboratoire de Neurobiologie de l'Apprentissage et de la Mémoire, CNRS-URA 1491, Université Paris Sud, Orsay, France.
Burette
F
F
Laroche
S
S
D000818:Animals; D004298:Dopamine / Q000494:pharmacology / Q000502:physiology; D006624:Hippocampus / Q000502:physiology*; D007858:Learning / Q000502:physiology*; D017774:Long-Term Potentiation / Q000187:drug effects / Q000502:physiology; D009473:Neuronal Plasticity; D017397:Prefrontal Cortex / Q000502:physiology*; D017966:Pyramidal Cells / Q000502:physiology*; D051381:Rats; D016194:Receptors, N-Methyl-D-Aspartate / Q000502:physiology; D013569:Synapses / Q000502:physiology*
D016194:Receptors, N-Methyl-D-Aspartate; D004298:Dopamine