title: The effect of tryptophan depletion on mood in medication-free, former patients with major affective disorder.
abstract: Acute tryptophan depletion (ATD) induces transient clinical relapse in medicated patients with major affective disorder. Our objective was to determine whether this effect persists once patients are euthymic and off antidepressants. Thus, we examined the effects of ATD in fully remitted, medication-free, former patients with major depression (n = 14). ATD had no significant effect on mood. These results suggest that the previous report that ATD substantially lowers mood in pharmacologically treated patients reflects a reversal of mechanisms involved in the therapeutic effects of antidepressants. Alternatively, ATD might induce clinical relapse only in subgroups that have yet to be identified.
authors.affiliation: Department of Psychiatry, McGill University, Montreal, Canada.
authors.forename: M
authors.initials: M
authors.lastname: Leyton
authors.forename: S N
authors.initials: SN
authors.lastname: Young
authors.forename: P
authors.initials: P
authors.lastname: Blier
authors.forename: M A
authors.initials: MA
authors.lastname: Ellenbogen
authors.forename: R M
authors.initials: RM
authors.lastname: Palmour
authors.forename: A M
authors.initials: AM
authors.lastname: Ghadirian
authors.forename: C
authors.initials: C
authors.lastname: Benkelfat
mesh_terms: D000328:Adult; D000339:Affect / Q000502:physiology*; D004032:Diet; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019964:Mood Disorders / Q000378:metabolism* / Q000523:psychology*; D011569:Psychiatric Status Rating Scales; D014364:Tryptophan / Q000502:physiology*
chemical_list: D014364:Tryptophan