title: Novastan anticoagulation during renal stent implant in a patient with heparin-induced thrombocytopenia.
abstract: We describe a case of a 70-year-old male who underwent coronary artery bypass surgery which was complicated by multiple thrombotic events associated with HIT. The thrombotic events were treated with intravenous argatroban (Novastan). During the hospitalization the patient was found to require percutaneous bilateral renal artery revascularization for acute renal failure. The revascularization procedure was successfully accomplished with a high dose argatroban regimen. We present our report of a successful anticoagulation strategy during a peripheral intervention in a patient with HIT and the laboratory data which support this strategy.
authors.affiliation: Columbus Hospital, Chicago, IL 60614, USA.
authors.forename: B E
authors.initials: BE
authors.lastname: Lewis
authors.forename: E D
authors.initials: ED
authors.lastname: Grassman
authors.forename: L
authors.initials: L
authors.lastname: Wrona
authors.forename: Y
authors.initials: Y
authors.lastname: Rangel
mesh_terms: D000368:Aged; D000925:Anticoagulants / Q000009:adverse effects*; D001120:Arginine / Q000031:analogs & derivatives; D001026:Coronary Artery Bypass; D006493:Heparin / Q000009:adverse effects*; D006801:Humans; D007431:Intraoperative Complications / Q000517:prevention & control; D007668:Kidney / Q000601:surgery*; D008297:Male; D010875:Pipecolic Acids / Q000008:administration & dosage*; D015607:Stents; D013449:Sulfonamides; D013921:Thrombocytopenia / Q000139:chemically induced* / Q000188:drug therapy
chemical_list: D000925:Anticoagulants; D010875:Pipecolic Acids; D013449:Sulfonamides; D006493:Heparin; D001120:Arginine; C031942:argatroban