Nonbinomial distribution of relative neurite outgrowth in PC-12 cells.
Previously we reported the results of a series of experimental tests using PC-12 cells to examine the biological effect of prescribed combinations of both nerve growth factor and magnetic fields. Because our assay of the PC-12 cells is based on binary classification of the cells following treatment, our data might be expected to have a binomial distribution. However, our data consistently show a smaller variability than that predicted by the binomial distribution model. In this paper, we examine some possible reasons for this reduction in variability in our results.
Blackman
C F
CF
U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711-2055, USA.
House
D E
DE
Blanchard
J P
JP
D000465:Algorithms; D000818:Animals; D016010:Binomial Distribution; D002452:Cell Count; D003470:Culture Media; D003627:Data Interpretation, Statistical; D008280:Magnetics / Q000145:classification; D009414:Nerve Growth Factors / Q000494:pharmacology*; D016501:Neurites / Q000187:drug effects / Q000473:pathology*; D016716:PC12 Cells / Q000473:pathology*; D011336:Probability; D051381:Rats
D003470:Culture Media; D009414:Nerve Growth Factors