[Comparison of serum concentrations of once and twice daily administration of ultra-retard theophylline in school children with bronchial asthma].
It was the aim of our study to find out whether once-daily administration of an ultra-retard preparation is meaningful also during childhood if compared to twice-daily application. To this end we examined 11 children (6 girls, 5 boys) between 7 and 16 years of age (median 12 years) who were suffering from bronchial asthma. The same theophylline daily dose was administered for 10 days each either as a single dose in the evening (20.00 hrs) or subdivided into two single doses (9.00 and 20.00 hrs). Dosage was according to age between 11 and 24 mg/kg body weight and day. The median values of blood serum concentration of theophylline of the once-daily or twice-daily administration in the "steady state" did not show any significant difference in the course of the 24-hour observation. The maximum effective concentration was attained after 12 hours in case of the once-daily application and after 8 hours with the twice-daily application. Summing up, our data indicate that good control of asthma bronchiale can be achieved even with once-daily administration of an ultra-retard preparation also in childhood. With both regimens the blood serum concentrations showed a satisfactorily low variability over 24 hours.
Liebke
C
C
Kinderklinik, Virchow-Klinikum, Humbold-Universität zu Berlin.
Niggemann
B
B
Wahn
U
U
D000293:Adolescent; D001249:Asthma / Q000097:blood / Q000188:drug therapy*; D001993:Bronchodilator Agents / Q000008:administration & dosage* / Q000009:adverse effects / Q000493:pharmacokinetics; D002648:Child; D003692:Delayed-Action Preparations; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D013806:Theophylline / Q000008:administration & dosage* / Q000009:adverse effects / Q000493:pharmacokinetics; D016896:Treatment Outcome
D001993:Bronchodilator Agents; D003692:Delayed-Action Preparations; D013806:Theophylline
Vergleich der Serumkonzentrationen bei einmal und zweimal täglicher Applikation eines ultraretardierten Theophyllin-Präparates bei Schulkindern mit Asthma bronchiale.