[An experimental study of the hemostatic system in acute radiation sickness exacerbated by skin burns].
The experiments on Wistar rats and mice (C57B16)F1 exposed to gamma irradiation at the doses of 4,5 to 7,5 Gy, alone and in combination with a III-B skin burn of 10-30% skin surface, showed that a combined injury results in a higher death rate. On a background of the bone marrow hemocytogenesis depression, a syndrome of disseminated intravascular blood coagulation and the irradiation-induced hemorrhagic syndrome develop. It was shown that the bone marrow depression and hemostasis disorders play an important role in the thanatogenesis of a combined radiation and thermal injury. The problems of diagnosis and therapy are discussed.
Ziablitskiĭ
V M
VM
Starosel'skaia
A N
AN
Romanovskaia
V N
VN
Zhavoronkov
L P
LP
Mikhal'skaia
T Iu
TIu
D000208:Acute Disease; D000818:Animals; D001780:Blood Coagulation Tests; D002056:Burns / Q000097:blood* / Q000401:mortality; D005260:Female; D005720:Gamma Rays; D006487:Hemostasis / Q000528:radiation effects*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D011833:Radiation Injuries, Experimental / Q000097:blood* / Q000150:complications / Q000401:mortality; D051381:Rats; D017208:Rats, Wistar; D012867:Skin / Q000293:injuries*; D013997:Time Factors
Eksøeromental'noe issledovanie sistemy gemostaza pri ostroĭ luchevoĭ bolezni, otiagoshchennoĭ ozhogom kozhi.