title: Intrahepatic metastatic nodules of hepatocellular carcinoma detected at lipiodol-CT: imaging-pathologic correlation.
abstract: BACKGROUND
  The purpose of this study was to determine whether tiny (< 2 cm) areas of iodized-oil retention diagnosed as intrahepatic metastatic nodules of hepatocellular carcinoma (HCC) at computed tomography (CT) following intraarterial injection of Lipiodol (Lipiodol-CT) correlate with truly cancerous foci on the corresponding sectioned pathologic specimens.
  
  
  METHODS
  Thirty-two consecutive patients with biopsy-proven HCC (26 men and six women, aged 41-72 years) underwent prospective evaluation with Lipiodol-CT before undergoing surgery (hepatic resection, 30 patients; liver transplantation, two patients). Imaging findings were correlated with intraoperative and pathologic findings.
  
  
  RESULTS
  Twenty-one areas of retained Lipiodol (0.5-1.6 cm in diameter, mean +/- SD: 0.9 +/- 0.3 cm) had features consistent with intrahepatic metastatic nodules of HCC on Lipiodol-CT scans. Nineteen of the 21 areas correlated with tumor deposits at pathologic examination of the surgical specimens, whereas two of 21 were due to abnormal retention of iodized oil within noncancerous liver parenchyma. The positive predictive value of findings at Lipiodol-CT for the diagnosis of intrahepatic metastatic nodule of HCC was 90.5%.
  
  
  CONCLUSIONS
  Findings at Lipiodol-CT enable a reliable diagnosis of intrahepatic metastatic nodules of HCC.
authors.affiliation: Department of Radiology, University of Pisa, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Lencioni
authors.forename: F
authors.initials: F
authors.lastname: Pinto
authors.forename: N
authors.initials: N
authors.lastname: Armillotta
authors.forename: M
authors.initials: M
authors.lastname: Di Giulio
authors.forename: P
authors.initials: P
authors.lastname: Gaeta
authors.forename: G
authors.initials: G
authors.lastname: Di Candio
authors.forename: S
authors.initials: S
authors.lastname: Marchi
authors.forename: C
authors.initials: C
authors.lastname: Bartolozzi
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000000981:diagnostic imaging* / Q000473:pathology / Q000556:secondary*; D003287:Contrast Media; D005260:Female; D006801:Humans; D007459:Iodized Oil; D008099:Liver / Q000473:pathology; D008113:Liver Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology / Q000556:secondary*; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed
chemical_list: D003287:Contrast Media; D007459:Iodized Oil