title: [Does stopping of oral feeding favour the occurrence of auriculoventricular block in premature infants treated with diphemanil?].
abstract: BACKGROUND
  Bradycardia in preterm infants may require anticholinergic therapy (diphemanil methylsulphate). Such treatment may cause prolongation of QT interval and auriculoventricular block.
  
  
  METHODS
  Three premature infants born before 34 weeks of gestational age were given 6-8 mg/kg/d diphemanil because they suffered from bradycardiac episodes. Aggravation and/or persistence of bradycardia required withdrawal of gavage feeding: heart block occurred within a few hours which subsided after cessation of diphemanil and oral refeeding. Diphemanil at progressive dosage was later introduced safely in two of these infants.
  
  
  CONCLUSIONS
  The short interval of time between the oral feeding withdrawal and occurrence of heart block justified therapy be stopped or transiently reduced whenever oral feeding must be interrupted.
authors.affiliation: Service de médecine néonatale, centre de pédiatrie Gatien-de-Clocheville, Tours, France.
authors.forename: M
authors.initials: M
authors.lastname: Guérois
authors.forename: A
authors.initials: A
authors.lastname: Favre
authors.forename: F
authors.initials: F
authors.lastname: Gold
authors.forename: M H
authors.initials: MH
authors.lastname: Blond
authors.forename: A
authors.initials: A
authors.lastname: Chantepie
authors.forename: C
authors.initials: C
authors.lastname: Rondeau
authors.forename: N
authors.initials: N
authors.lastname: Ramponi
authors.forename: E
authors.initials: E
authors.lastname: Autret
mesh_terms: D000284:Administration, Oral; D005260:Female; D006327:Heart Block / Q000139:chemically induced*; D006801:Humans; D007227:Infant Nutritional Physiological Phenomena; D007231:Infant, Newborn; D007234:Infant, Premature; D008297:Male; D010276:Parasympatholytics / Q000009:adverse effects*; D010880:Piperidines / Q000009:adverse effects*
chemical_list: D010276:Parasympatholytics; D010880:Piperidines; C028209:diphemanil methylsulfate
vernacular_title: L'arrêt de l'alimentation orale favorise-t-il la survenue d'un bloc auriculoventriculaire chez les prématurés traités par diphémanil?