Histone acetyltransferases in control.
Several transcriptional regulators have been found to act as enzymes that acetylate histones. The targeted post-translational modification of histones within regulatory nucleoprotein complexes provides an attractive mechanism for controlling transcription within a chromatin environment.
Wade
P A
PA
Laboratory of Molecular Embryology, NICHHD, Bethesda, Maryland, 20892-5431, USA. awlme@helix.nih.gov
Wolffe
A P
AP
D000123:Acetyltransferases / Q000378:metabolism*; D000818:Animals; D002843:Chromatin / Q000502:physiology*; D005786:Gene Expression Regulation; D051548:Histone Acetyltransferases; D006655:Histone Deacetylases / Q000378:metabolism; D008954:Models, Biological; D012441:Saccharomyces cerevisiae / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins; D014158:Transcription, Genetic; D015533:Transcriptional Activation
D002843:Chromatin; D029701:Saccharomyces cerevisiae Proteins; D000123:Acetyltransferases; D051548:Histone Acetyltransferases; D006655:Histone Deacetylases