title: The equivalent bronchodilator effects of salbutamol formulated in chlorofluorocarbon and hydrofluoroalkane-134a metered dose inhalers on the histamine-induced pulmonary response in dogs.
abstract: OBJECTIVE
  The bronchodilator effect of salbutamol formulated in hydrofluoroalkane-134a (HFA-134a), a chlorofluorocarbon (CFC)-free propellant for metered dose inhalation (MDI) devices, was compared with that of salbutamol formulated in CFC in anesthetized dogs.
  
  
  METHODS
  Bronchospasms were induced by the intravenous injection of histamine, and bronchial resistance was measured by the method of Konzett and Rossler.
  
  
  RESULTS
  While the placebo vehicles (HFA-134a and CFC propellants) had no significant effect on histamine-induced bronchospasms, the salbutamol/HFA-134a and salbutamol/CFC MDI formulations had equivalent dose-related inhibitory effects.
  
  
  CONCLUSIONS
  These data indicated that salbutamol formulated in HFA-134a and that in CFC propellant are bioequivalent.
authors.affiliation: Dainippon Pharmaceutical Co., Ltd., Osaka, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Nogami-Itoh
authors.forename: I
authors.initials: I
authors.lastname: Yakuo
authors.forename: D M
authors.initials: DM
authors.lastname: Hammerbeck
authors.forename: R L
authors.initials: RL
authors.lastname: Miller
authors.forename: K
authors.initials: K
authors.lastname: Takeyama
mesh_terms: D000420:Albuterol / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D016084:Bronchoconstriction / Q000187:drug effects* / Q000502:physiology; D001993:Bronchodilator Agents / Q000494:pharmacology*; D017402:Chlorofluorocarbons; D004285:Dogs; D006339:Heart Rate / Q000187:drug effects; D006632:Histamine / Q000494:pharmacology*; D006845:Hydrocarbons, Fluorinated; D008297:Male; D009330:Nebulizers and Vaporizers; D013810:Therapeutic Equivalency; D005466:Fluorocarbons
chemical_list: D000420:Albuterol; D001993:Bronchodilator Agents; D017402:Chlorofluorocarbons; D006632:Histamine; D006845:Hydrocarbons, Fluorinated; C094049:apaflurane; D005466:Fluorocarbons