Blockade of morphine-induced hindlimb myoclonic seizures in mice by ketamine.
Morphine administration can lead to a variety of side-effects, including myoclonus. In an animal model, high morphine doses given intrathecally elicit hindlimb myoclonic seizures which are not influenced by traditional opioid receptor antagonists, such as naloxone. Ketamine prevents this seizure-like activity in a dose-dependent manner. The response is stereoselective, with S-ketamine far more potent than R-ketamine. A competitive NMDA antagonist, NPC17742, also prevents the seizures, although less potently than ketamine. Dextromethorphan has limited activity in this model, while haloperidol and pentothal are without any effect.
Kolesnikov
Y
Y
Department of Anesthesiology, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.
Jain
S
S
Wilson
R
R
Pasternak
G W
GW
D000596:Amino Acids / Q000494:pharmacology; D000701:Analgesics, Opioid / Q000009:adverse effects* / Q000037:antagonists & inhibitors; D000818:Animals; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004831:Epilepsies, Myoclonic / Q000139:chemically induced / Q000188:drug therapy*; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology*; D006614:Hindlimb; D007649:Ketamine / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009020:Morphine / Q000009:adverse effects* / Q000037:antagonists & inhibitors; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors*; D013237:Stereoisomerism
D000596:Amino Acids; D000701:Analgesics, Opioid; D018691:Excitatory Amino Acid Antagonists; D016194:Receptors, N-Methyl-D-Aspartate; C060212:NPC 12626; D007649:Ketamine; D009020:Morphine