title: Review and hypothesis: the eosinophil and peripartum heart disease (myocarditis and coronary artery dissection)--coincidence or pathogenetic significance?
abstract: OBJECTIVE
  To examine a possible relationship between peripartum heart disease (myocarditis and spontaneous coronary dissection) and the presence of eosinophils.
  
  
  BACKGROUND
  Eosinophils have been shown to have potential collagenolytic and cytotoxic activity. Eosinophils may play a role in postpartum uterine involution. The presence of eosinophils in spontaneous coronary dissection and myocarditis in the postpartum period raises the possibility of a role for eosinophils in these diseases.
  
  
  METHODS
  We reviewed the files of one of us (S.M.F.) for cases of peripartum myocarditis and spontaneous coronary dissection and assessed the frequency of eosinophilic inflammation. Seventeen postpartum myocarditis and/or cardiomyopathy cases were found and two spontaneous coronary dissections. Fifteen sex- and age-matched controls on non-postpartum myocarditis and borderline myocarditis were evaluated and eosinophil counts per unit area compared. Also, a Medline search of all previously published cases of spontaneous coronary dissection was performed back to 1966.
  
  
  RESULTS
  Of the 16 heart biopsies and one autopsy in the peripartum period, 10 were shown to contain easily identified eosinophils (6 myocarditis, 1 borderline, 3 cardiomyopathy). When presence of eosinophils was compared with the control group, a statistically significant difference was obtained (P = 0.036). The two new spontaneous coronary dissection cases had eosinophils along the dissection plane; the literature search produced 13 of 24 autopsied peripartum spontaneous coronary dissections with eosinophils for a total of 15 of 26 with our cases.
  
  
  CONCLUSIONS
  An association exists between eosinophils and peripartum cardiac disease (myocarditis and spontaneous coronary dissection). The role of eosinophils in labor, uterine involution and collagenolysis and the possible relation to cardiac disease are discussed.
authors.affiliation: Department of Pathology, Albert Einstein College of Medicine, Bronx, NY, USA.
authors.forename: A C
authors.initials: AC
authors.lastname: Borczuk
authors.forename: K H
authors.initials: KH
authors.lastname: van Hoeven
authors.forename: S M
authors.initials: SM
authors.lastname: Factor
mesh_terms: D000784:Aortic Dissection / Q000276:immunology*; D003323:Coronary Aneurysm / Q000276:immunology*; D004804:Eosinophils / Q000502:physiology*; D005260:Female; D006801:Humans; D009205:Myocarditis / Q000276:immunology*; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000276:immunology*