[Hypereosinophilia after allogeneic bone marrow transplantation. A possible role of IL-5 overproduction by donor T-cells chronic GVHD].
Chronic graft-versus-host disease (GVHD) is thought to result from abnormalities of several cytokine regulations in vivo. We analyzed interleukin-5 (IL-5) production by peripheral lymphocytes in a patient showing hypereosinophilia associated with chronic GVHD after allogeneic bone marrow transplantation. IL-5 production by activated T-lymphocytes which are known to play a major role in chronic GVHD was upregulated when stimulated by PMA + ionomycin. Therefore, hypereosinophilia observed in our patient may be correlated with IL-5 production in donor T-lymphocytes.
Masumoto
A
A
4th department of Internal Medicine, Tokai University School of Medicine.
Sasao
T
T
Yoshiba
F
F
Kato
S
S
Mori
A
A
Okudaira
H
H
Hotta
T
T
D000293:Adolescent; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D002908:Chronic Disease; D004802:Eosinophilia / Q000209:etiology*; D006086:Graft vs Host Disease / Q000276:immunology*; D006801:Humans; D015848:Interleukin-5 / Q000096:biosynthesis*; D008297:Male; D013601:T-Lymphocytes / Q000276:immunology*; D014019:Tissue Donors; D014184:Transplantation, Homologous
D015848:Interleukin-5