Summary of serological test results on the monoclonal antibodies to non-specific erythrocytes antigens.
Monoclonal antibodies from the 2D3 Section (Other Non-specific Erythrocyte Antigens) of the Third International Workshop & Symposium on Monoclonal Antibodies Against Human Red Blood Cell and Related Antigens were tested using standard serological tube methods. Each antibody was tested to determine the presence of prozoning. A selected panel of red blood cells was tested against each antibody at different phases. Anti-CD44 specificities were weaker or non-reactive with Lu(a-b-) InLu cells and 2 sources (2D3-1 and 2D3-2) were slightly decreased with Ko cells. Anti-CD47 and antibodies to Rh related molecules showed decreased or no reactivity with Rh null cells. Anti-CD99 showed weak or no reactivity with Gy-, LW:-3 and cord blood cells.
Lukasavage
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Pacific Northwest Region American Red Cross, Portland, OR 97227, USA.
Harris
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D000911:Antibodies, Monoclonal; D015703:Antigens, CD / Q000276:immunology*; D000939:Epitopes; D004912:Erythrocytes / Q000276:immunology*; D006801:Humans; D007519:Isoantigens / Q000276:immunology*; D010641:Phenotype; D012699:Serology
D000911:Antibodies, Monoclonal; D015703:Antigens, CD; D000939:Epitopes; D007519:Isoantigens