[Suppression of the reproduction of the human immunodeficiency virus (HIV) with a cytokine-like antiviral factor].
Cytokine-like antivirus factor, obtained from the culture fluid of chick embryo fibroblasts, was found to possess inhibitory activity with respect to HIV-1 (strains 1/Zmb and RF). The treatment of HIV-infected cell culture with cytokine-like factor was accompanied by a decrease in the cytopathic effect of the agent without manifestations of cytotoxicity. The combined use of the cytokine-like factor and azidothymidine at near-threshold concentrations was not accompanied by an increase in the antivirus effect, observed after the use of each preparation separately.
Gribkova
N V
NV
Eremin
V F
VF
Votiakov
V I
VI
Shchelkanov
M Iu
MIu
Pashkova
T A
TA
Karamov
E V
EV
D000818:Animals; D000998:Antiviral Agents / Q000302:isolation & purification / Q000494:pharmacology*; D002642:Chick Embryo; D003470:Culture Media; D016207:Cytokines / Q000302:isolation & purification / Q000494:pharmacology*; D003588:Cytopathogenic Effect, Viral / Q000187:drug effects; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D015497:HIV-1 / Q000187:drug effects* / Q000502:physiology; D014776:Virus Cultivation; D014779:Virus Replication / Q000187:drug effects*; D015215:Zidovudine / Q000494:pharmacology
D000998:Antiviral Agents; D003470:Culture Media; D016207:Cytokines; D015215:Zidovudine
Podavlenie reproduktsii virusa immunodefitsita cheloveka (VICh) tsitokinopodobnym antivirusnym faktorom.