title: Successful immunomodulation with intravenous gamma globulin and cyclophosphamide in an alloimmunized heart transplant recipient.
abstract: A highly human leukocyte antigen-sensitized heart transplant candidate underwent immunomodulation with intravenous gamma globulin and cyclophosphamide. His panel reactive antibody screen fell from 64% to 14%. He underwent successful orthotopic heart transplantation with a histoincompatible, T-cell cross-match-negative heart without the development of hyperacute rejection. The combination of intravenous gamma globulin and cyclophosphamide may be a simple and effective means to overcome the human leukocyte antigen-barrier in sensitized heart transplant candidates.
authors.affiliation: Division of Cardiology, University of California, San Francisco 94143-0124, USA.
authors.forename: T
authors.initials: T
authors.lastname: De Marco
authors.forename: L E
authors.initials: LE
authors.lastname: Damon
authors.forename: B
authors.initials: B
authors.lastname: Colombe
authors.forename: F
authors.initials: F
authors.lastname: Keith
authors.forename: K
authors.initials: K
authors.lastname: Chatterjee
authors.forename: M R
authors.initials: MR
authors.lastname: Garovoy
mesh_terms: D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000008:administration & dosage*; D006084:Graft Rejection / Q000276:immunology / Q000628:therapy*; D006333:Heart Failure / Q000276:immunology / Q000628:therapy*; D016027:Heart Transplantation / Q000276:immunology*; D006650:Histocompatibility Testing; D006801:Humans; D007116:Immunization, Passive; D007166:Immunosuppressive Agents / Q000008:administration & dosage*; D007519:Isoantigens / Q000097:blood*; D008297:Male; D008875:Middle Aged
chemical_list: D007166:Immunosuppressive Agents; D007519:Isoantigens; D003520:Cyclophosphamide