Bioavailability of phenytoin and anticonvulsant activity after oral administration of phenytoin-bis-hydroxyisobutyrate to rats.
Scriba
G K
GK
Department of Pharmaceutical Chemistry, School of Pharmacy, University of Münster, Germany.
Lambert
D M
DM
D000284:Administration, Oral; D000818:Animals; D000927:Anticonvulsants / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use; D001682:Biological Availability; D006885:Hydroxybutyrates / Q000493:pharmacokinetics*; D008297:Male; D010672:Phenytoin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics* / Q000627:therapeutic use; D011355:Prodrugs; D051381:Rats; D017208:Rats, Wistar; D012640:Seizures / Q000188:drug therapy*
D000927:Anticonvulsants; D006885:Hydroxybutyrates; D011355:Prodrugs; C106138:phenytoin-bis-hydroxyisobutyrate; D010672:Phenytoin