title: Age is not a limiting factor for radical radiotherapy in pelvic malignancies.
abstract: OBJECTIVE
  Pelvic radiotherapy (RT) toxicity in the elderly is poorly documented. We developed a study aiming to evaluate whether or not a limit of age could be identified beyond which toxicities in patients receiving pelvic RT were more frequent or more severe.
  
  
  METHODS
  1619 patients with pelvic cancers enrolled in nine EORTC trials, RT arms, were retrospectively studied. Patients were split into six age ranges from 50 years to 70 years and over. Survivals and late toxicity occurrence were calculated with the Kaplan-Meier method and comparison between age groups with the logrank test. A trend test was done to examine if chronological age had an impact on acute toxicity occurrence.
  
  
  RESULTS
  Survival was comparable in each age group for prostate (P = 0.18), uterus (0.41), anal canal cancer (P = 0.6) and slightly better for the younger group of rectum cancer (P = 0.04). A total of 1722 acute and 514 late grade > or = 1 were recorded. Acute nausea/ vomiting, skin complications and performance status deterioration were significantly more frequent in younger patients. There was no trend toward more aged patients to experience diarrhea (P = 0.149) and after adjustment on RT dose, acute urinary complications were observed equally in each age range (P = 0.32). Eighty percent of patients were free of late complication at 5 years in each age range (P = 0.79). For the grade > 2 late side-effects, a plateau was observed after 1 year at near 9% without any difference (P = 0.06) nor trend (P = 0.13) between age-groups.
  
  
  CONCLUSIONS
  Age per se is not a limiting factor for radical radiotherapy in pelvic malignancies.
authors.affiliation: Department of Radiotherapy-Oncology, Hôpital de la Timone, Marseille, France.
authors.forename: T
authors.initials: T
authors.lastname: Pignon
authors.forename: J C
authors.initials: JC
authors.lastname: Horiot
authors.forename: M
authors.initials: M
authors.lastname: Bolla
authors.forename: H
authors.initials: H
authors.lastname: van Poppel
authors.forename: H
authors.initials: H
authors.lastname: Bartelink
authors.forename: F
authors.initials: F
authors.lastname: Roelofsen
authors.forename: F
authors.initials: F
authors.lastname: Pene
authors.forename: A
authors.initials: A
authors.lastname: Gerard
authors.forename: N
authors.initials: N
authors.lastname: Einhorn
authors.forename: T D
authors.initials: TD
authors.lastname: Nguyen
authors.forename: M
authors.initials: M
authors.lastname: Vanglabbeke
authors.forename: P
authors.initials: P
authors.lastname: Scalliet
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D003967:Diarrhea / Q000209:etiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009325:Nausea / Q000209:etiology; D010386:Pelvic Neoplasms / Q000532:radiotherapy*; D010865:Pilot Projects; D011878:Radiotherapy / Q000009:adverse effects; D012189:Retrospective Studies; D012735:Sexual Dysfunction, Physiological / Q000209:etiology; D012867:Skin / Q000528:radiation effects; D014555:Urination Disorders / Q000209:etiology; D014839:Vomiting / Q000209:etiology