Trauma-induced striatal CNTF and BDNF mRNA in hemiparkinsonian rats.
Surgical implantation of tissues into the brain causes trauma to the region receiving the graft. This study shows that real or simulated striatal trauma in hemiparkinsonian rats leads to increased expression of two trophic factor mRNAs: ciliary neurotrophic factor (CNTF) and brain-derived neurotrophic factor (BDNF). The baseline expression of BDNF mRNA was also markedly lower in dopamine-depleted striatum than in normal striatum in non-traumatized (control) hemiparkinsonian rats. Striatal CNTF message was relatively symmetrical in the non-traumatized (control) hemiparkinsonian rats. Host production of these and other trophic factors may play important roles in the response to tissue grafting, to enhance graft survival and as a stimulus to regenerative collateral axonal sprouting.
Plunkett
R J
RJ
Department of Neurosurgery, SUNY at Buffalo, USA.
Ip
N Y
NY
Asada
H
H
Friedman
B
B
Pan
L
L
Kaseloo
P A
PA
Parfitt
M M
MM
D000818:Animals; D016380:Brain Tissue Transplantation / Q000502:physiology*; D019208:Brain-Derived Neurotrophic Factor / Q000378:metabolism*; D020934:Ciliary Neurotrophic Factor; D004195:Disease Models, Animal; D017403:In Situ Hybridization; D008297:Male; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D010300:Parkinson Disease / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley
D019208:Brain-Derived Neurotrophic Factor; D020934:Ciliary Neurotrophic Factor; D009419:Nerve Tissue Proteins; D012333:RNA, Messenger