Polyclonal Ki-67 expression in transitional cell carcinoma of the bladder.
The proliferation kinetics of 101 cases of transitional cell carcinoma (TCC) and seven cases of transitional cell carcinoma-in-situ of the bladder were assessed following staining with polyclonal Ki-67 antibody (pKi-67). Labeling indices ranged from 49% to 60.2% with a mean value of 22.2% for all cases. A significant association between pKi-67 indices, tumor grade and tumor stage was observed, with significant differences between pKi-67 indices of Grade 1 and 3 tumors and Grade 2 and 3 tumors. Significant differences in labeling indices were also found between superficial (Ta) tumors and both musculoinvasive (T2/T3a) tumors and those infiltrating the perivesical fat (T3b). pKi-67 indices for carcinoma-in-situ were similar to those noted for Grade 1 TCC. No difference in pKi-67 index was found when tumors were classified according to the morphology of the tumor invasion front. It is concluded that pKi-67 index is a useful marker for tumor progression for vesical TCC and that this immunohistochemical stain may assist clinical assessment of the potential behaviour of tumors in individual cases.
Jones
H L
HL
Department of Pathology, Wellington School of Medicine, New Zealand.
Delahunt
B
B
Bethwaite
P B
PB
Thornton
A
A
D000951:Antigens, Neoplasm / Q000032:analysis*; D002295:Carcinoma, Transitional Cell / Q000276:immunology* / Q000473:pathology; D002455:Cell Division / Q000276:immunology; D018450:Disease Progression; D006801:Humans; D019394:Ki-67 Antigen / Q000032:analysis*; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D001749:Urinary Bladder Neoplasms / Q000276:immunology* / Q000473:pathology
D000951:Antigens, Neoplasm; D019394:Ki-67 Antigen