title: Regional cerebral blood flow and oxygen metabolism in a patient with Korsakoff syndrome.
abstract: We report a functional neuroimaging study of a patient clinically diagnosed with Korsakoff syndrome. Positron emission tomography (PET) with the 15O inhalation method showed decreased regional cerebral blood flow (rCBF) and decreased regional cerebral metabolic ratio for oxygen (rCMRO2) in the bilateral fronto-temporal areas and in the left thalamus. These results suggest that dysfunction of the frontal-thalamic neural network plays a role in the disturbance of Korsakoff syndrome.
authors.affiliation: Divisions of Neuroimaging Research, Hyogo Institute for Aging Brain and Cognitive Disorders (HI-ABCD), Japan.
authors.forename: K
authors.initials: K
authors.lastname: Matsuda
authors.forename: S
authors.initials: S
authors.lastname: Yamaji
authors.forename: K
authors.initials: K
authors.lastname: Ishii
authors.forename: M
authors.initials: M
authors.lastname: Sasaki
authors.forename: S
authors.initials: S
authors.lastname: Sakamoto
authors.forename: H
authors.initials: H
authors.lastname: Kitagaki
authors.forename: T
authors.initials: T
authors.lastname: Imamura
authors.forename: E
authors.initials: E
authors.lastname: Mori
mesh_terms: D000425:Alcohol Amnestic Disorder / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000503:physiopathology*; D002560:Cerebrovascular Circulation; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010101:Oxygen Consumption; D010104:Oxygen Radioisotopes; D012039:Regional Blood Flow; D014018:Tissue Distribution; D014055:Tomography, Emission-Computed; D014899:Wernicke Encephalopathy / Q000000981:diagnostic imaging
chemical_list: D010104:Oxygen Radioisotopes