Nature of the T lymphocytes in lymphocyte predominance Hodgkin's disease.
Little is known about the function of the T lymphocytes in lymphocyte predominance Hodgkin's disease. We report here the case of a 37-year-old man with a diffuse LPHD, featuring a similar increase in T lymphocytes in both the peripheral blood and the tumor, thus allowing for their characterization by functional assays. These cells were CD4+CD45RO+ and produced high amounts of IL-2 and IFN-gamma, consistent with a TH1-type profile. This subset of T helper cells is involved in cellular immunity and could reflect a cytotoxic reaction directed against the neoplastic cells.
Dargent
J L
JL
Department of Pathology, ULB-Hopital Erasme, Brussels, Belgium.
Schandene
L
L
Kornreich
A
A
Lespagnard
L
L
Cochaux
P
P
Jagodzinski
R
R
Capel
P
P
Velu
T
T
Neve
P
P
D000328:Adult; D015703:Antigens, CD / Q000032:analysis; D005434:Flow Cytometry; D006689:Hodgkin Disease / Q000097:blood / Q000276:immunology / Q000473:pathology*; D006801:Humans; D007111:Immunity, Cellular / Q000502:physiology; D007371:Interferon-gamma / Q000096:biosynthesis; D007376:Interleukin-2 / Q000096:biosynthesis; D008213:Lymphocyte Activation; D008297:Male; D013601:T-Lymphocytes / Q000276:immunology / Q000378:metabolism / Q000502:physiology*
D015703:Antigens, CD; D007376:Interleukin-2; D007371:Interferon-gamma