Fortuitous diagnosis of the association of hemoglobin J-Broussais with beta + thalassemia.
The authors report a case, not described so far in literature, of an association of HbJ-Broussais [alpha (90 (PG2) lys-->asn beta 2] with beta + thalassemia in a young girl born of Italian father and Breton mother. This association is clinically silent. Biochemistry revealed, besides HbA, the presence of HbJ-Broussais in the proportion of 19.4% and HbA2 value of 3.9%. These percentages, slightly lower than expected, are explained. A familial study is presented.
Durou
M R
MR
Laboratoire de biochimie, Centre Hospitalier et Universitaire, Hôpital Sud, Rennes, France.
Ribault
A
A
Dufour
M J
MJ
Gallou
G
G
Ruelland
A
A
Le Gall
E
E
Cloarec
L
L
Legras
B
B
D002648:Child; D005260:Female; D006448:Hemoglobin J / Q000235:genetics*; D006801:Humans; D010375:Pedigree; D017086:beta-Thalassemia / Q000235:genetics*
D006448:Hemoglobin J