Bone tissue reactions to an electrophoretically applied calcium phosphate coating.
Oral implants of a threaded design, calcium phosphate (CaP)-coated using an electrophoretic deposition technique, were compared to uncoated commercially pure (c.p.) titanium control in an animal study with 4 weeks and 6 months of follow-up, respectively. The 3D surface roughness of a CaP-coated implant was about three times greater than that of an uncoated control. Histomorphometric analyses of the direct bone-implant contact demonstrated a short-term advantage to the CaP-coated implants, whereas no significant difference to the uncoated titanium was found after 6 months. Comparison of the amount of bone inside or outside the threads showed similar values for test and control after 4 weeks. Significantly higher amounts of bone outside the uncoated c.p. titanium implants were measured after the long-term follow-up.
Gottlander
M
M
Department of Biomaterials/Handicap Research, University of Göteborg, Sweden.
Johansson
C B
CB
Wennerberg
A
A
Albrektsson
T
T
Radin
S
S
Ducheyne
P
P
D000818:Animals; D001672:Biocompatible Materials; D018786:Bone Substitutes; D001842:Bone and Bones / Q000187:drug effects; D002130:Calcium Phosphates / Q000494:pharmacology*; D004586:Electrophoresis / Q000379:methods; D008422:Materials Testing; D011817:Rabbits; D013499:Surface Properties; D013997:Time Factors; D014025:Titanium
D001672:Biocompatible Materials; D018786:Bone Substitutes; D002130:Calcium Phosphates; C485828:alpha-tricalcium phosphate; C485830:tetracalcium phosphate; C485838:calcium phosphate, monobasic, anhydrous; C020243:calcium phosphate; D014025:Titanium; C485829:calcium phosphate, dibasic, anhydrous