[The biochemical and clinical aspects of the participation of granulocytes and their proteinases in a vascular wall lesion].
Some components of plasma and granulocyte proteolytic system, granulocyte activation degree were evaluated in 15 patients with nonspecific aortic arteritis (NAA) and 12 hereditary hypercholesterolemia (HHC) patients. Catepsin G activity in blood plasma of NAA and HHC patients was higher than in donors 8-9 and 6-fold, respectively (p < 0.001). Granulocyte collagenase activity, spontaneous NBT test values in them were higher than in donors 6 and 4-fold (p < 0.02 and p < 0.01, respectively), 2-fold (p < 0.005 and p < 0.001, respectively). The data obtained confirm the suggestion on the presence of an inflammatory component not only in pathogenesis of NAA, but also in HHC causation.
Ogloblina
O G
OG
Belova
L A
LA
Arkhakova
I A
IA
Domba
G Iu
GIu
Arabidze
G G
GG
Kukharchuk
V V
VV
D000293:Adolescent; D000328:Adult; D001025:Aortitis / Q000201:enzymology / Q000209:etiology*; D001167:Arteritis / Q000201:enzymology / Q000209:etiology*; D056649:Cathepsin G; D002403:Cathepsins / Q000097:blood; D017364:Collagenases / Q000097:blood; D010450:Endopeptidases / Q000097:blood*; D005260:Female; D006098:Granulocytes / Q000201:enzymology*; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000201:enzymology / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D012697:Serine Endopeptidases / Q000097:blood
D002403:Cathepsins; D010450:Endopeptidases; D012697:Serine Endopeptidases; C534094:CTSG protein, human; D056649:Cathepsin G; D017364:Collagenases
Biokhimicheskie i klinicheskie aspekty uchastiia granulotsitov i ikh proteinaz v porazhenii stenki sosudov.