Immunologic aspects of dermal and oral lichen planus: a review.
There have been many investigations, both experimental and epidemiologic, of the forms of LP affecting the skin and oral mucosae. These studies have provided a varied range of hypotheses to explain not only the factors determining susceptibility to and onset of this disease, but also the immunologic mechanisms leading to the pathosis with which LP is associated. Much progress has been made, especially through in vitro studies, regarding detailed aspects of the immunology of LP. However, data is often conflicting or incomplete. In this review we attempt to bring together the currently available data regarding the immunologic basis of LP.
Porter
S R
SR
Department of Oral Medicine, Eastman Dental Institute, London, UK.
Kirby
A
A
Olsen
I
I
Barrett
W
W
D000818:Animals; D000937:Antigen-Antibody Reactions; D015815:Cell Adhesion Molecules / Q000276:immunology; D016207:Cytokines / Q000096:biosynthesis; D003713:Dendritic Cells / Q000276:immunology; D016326:Extracellular Matrix Proteins / Q000276:immunology; D005192:Family Health; D006680:HLA Antigens / Q000276:immunology; D006801:Humans; D015603:Keratinocytes / Q000378:metabolism; D008010:Lichen Planus / Q000235:genetics / Q000276:immunology*; D017676:Lichen Planus, Oral / Q000235:genetics / Q000276:immunology*; D013601:T-Lymphocytes / Q000378:metabolism
D015815:Cell Adhesion Molecules; D016207:Cytokines; D016326:Extracellular Matrix Proteins; D006680:HLA Antigens