The oncogenic potential of eleven avian adenovirus strains.
Oncogenic potentials of 11 strains of avian adenovirus representing 10 serotypes were investigated in 22 litters of 1-day-old Syrian hamsters (Mesocricetus auratus). Hamsters were inoculated via two routes: subcutaneous dose of 0.12 ml and intracerebral dose of 0.02 ml. Six strains, Indiana-C (Ind-C), chicken embryo lethal orphan (CELO), Stein, 75-1A, B-3, and A-2, induced fibrosarcomas subcutaneously at the inoculation site. Hamsters inoculated intracerebrally with Ind-C, CELO, Stein, B-3, and A-2 developed carcinomas of the choroid plexus. Strain 75-1A virus produced tumors on subcutaneous inoculation but failed to produce tumors on intracerebral inoculation. The Tipton, J-2, T-8, C-2B, and X-11 strains did not produce tumors in hamsters. Uninoculated control hamsters did not develop tumors.
Dhillon
A S
AS
Department of Microbiology and Pathology, College of Veterinary Medicine, Washington State University-Puyallup 98371-4919, USA.
Jack
O K
OK
D000257:Adenoviridae Infections / Q000473:pathology*; D000818:Animals; D000259:Aviadenovirus / Q000145:classification / Q000302:isolation & purification / Q000472:pathogenicity*; D002277:Carcinoma / Q000821:virology*; D002645:Chickens; D016545:Choroid Plexus Neoplasms / Q000821:virology*; D006224:Cricetinae; D005354:Fibrosarcoma / Q000821:virology*; D008647:Mesocricetus; D012703:Serotyping; D012878:Skin Neoplasms / Q000821:virology; D013045:Species Specificity