CREB phosphorylation in the nucleus of the solitary tract and parabrachial nucleus is not altered by peripheral cholecystokinin that induces c-Fos.
Ca ++/cAMP response element binding protein (CREB), phosphoCREB, and c-Fos-like (c-FL) immunoreactivity (IR) were examined in the nucleus of the solitary tract (NTS) and parabrachial nucleus (PBN) after peripheral cholecystokinin (CCK). c-FLIR was observed only after CCK, but CCK did not alter high basal levels of CREB-IR and phosphoCREB-IR. PhosphoCREB may be necessary but is not sufficient to induce c-Fos after CCK injection.
Houpt
T A
TA
E.W. Bourne Behavioral Research Laboratory, Department of Psychiatry, Cornell University Medical College, White Plains, NY 10605, USA. tah2@cornell.edu
D000818:Animals; D002766:Cholecystokinin / Q000494:pharmacology*; D017362:Cyclic AMP Response Element-Binding Protein / Q000032:analysis / Q000378:metabolism*; D004435:Eating / Q000502:physiology; D017781:Genes, Immediate-Early / Q000502:physiology; D007150:Immunohistochemistry; D008297:Male; D010766:Phosphorylation; D016760:Proto-Oncogene Proteins c-fos / Q000096:biosynthesis* / Q000378:metabolism; D051381:Rats; D017552:Solitary Nucleus / Q000737:chemistry* / Q000187:drug effects / Q000378:metabolism; D014157:Transcription Factors / Q000502:physiology
D017362:Cyclic AMP Response Element-Binding Protein; D016760:Proto-Oncogene Proteins c-fos; D014157:Transcription Factors; D002766:Cholecystokinin