Prognostic factors of prenatally diagnosed gastroschisis.
OBJECTIVE
To evaluate the prognosis of prenatally diagnosed gastroschisis.


METHODS
In a retrospective study, we analyzed the clinical and echographic data of gastroschisis. These data were correlated with fetal outcome including delivery, surgical procedure, follow-up in the neonatal intensive-case unit and in the gastropediatric unit.


RESULTS
Twenty cases were analyzed. The overall survival rate was 85%. Classical criteria were analyzed (maximal bowel dilatation, thickening of bowel wall). Fetuses with both severe perivisceritis and meconium-stained amniotic fluid were born earlier than fetuses with mild perivisceritis and normal amniotic fluid (p < 0.01).


CONCLUSIONS
Our data suggest that an inflammatory response could follow bowel exposure to amniotic fluid. This response could lead to perivisceritis and premature birth. This hypothesis is currently under investigation.
Luton
D
D
Département de Périnatalogie, Hôpital Robert-Debré, Paris, France.
De Lagausie
P
P
Guibourdenche
J
J
Oury
J F
JF
Vuillard
E
E
Sibony
O
O
Farnoux
C
C
Aigrain
Y
Y
Blot
P
P
D000293:Adolescent; D000328:Adult; D000653:Amniotic Fluid; D004064:Digestive System / Q000000981:diagnostic imaging; D004065:Digestive System Abnormalities; D013505:Digestive System Surgical Procedures; D005260:Female; D005315:Fetal Diseases / Q000000981:diagnostic imaging; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D015931:Intensive Care, Neonatal; D008470:Meconium; D011247:Pregnancy; D011379:Prognosis; D012189:Retrospective Studies; D016216:Ultrasonography, Prenatal; D014470:Umbilical Cord / Q000002:abnormalities*