Effect of increased bromide intake on iodine excretion in rats.
The time course of iodine excretion in adult male rats substantially differs from bromine excretion. Bromine is excreted at a single rate, whereas iodine evinces two excretion rates. Even a strong increase in bromide intake in experimental animals failed to affect the rate of iodine excretion but it lowered the fraction of iodine accumulated in the thyroid gland by 20% probably by affecting the transport of iodide into the thyroid gland.
Vobecký
M
M
Academy of Sciences of Czech Republic, Institute of Analytical Chemistry, Praha, Czech Republic.
Babický
A
A
Lener
J
J
D000818:Animals; D001965:Bromides / Q000008:administration & dosage / Q000494:pharmacology*; D001966:Bromine / Q000378:metabolism*; D006207:Half-Life; D007279:Injections, Subcutaneous; D007455:Iodine / Q000378:metabolism*; D007457:Iodine Radioisotopes; D007553:Isotope Labeling; D008297:Male; D011877:Radionuclide Imaging; D051381:Rats; D017208:Rats, Wistar; D013961:Thyroid Gland / Q000000981:diagnostic imaging / Q000378:metabolism*; D014915:Whole-Body Counting
D001965:Bromides; D007457:Iodine Radioisotopes; D007455:Iodine; D001966:Bromine