title: Distribution and functions of platelet-derived growth factors and their receptors during embryogenesis.
abstract: Platelet-derived growth factors (PDGFs) are soluble proteins that mediate intercellular signaling via receptor tyrosine kinases. The patterns of PDGF and PDGF receptor expression during embryogenesis are complex and dynamic and suggest that signaling can be autocrine or paracrine, depending on the particular tissue and the stage of development. Mesenchymal cells throughout the embryo and within some developing organs produce PDGF receptors, whereas their ligands are often produced by adjacent epithelial or endothelial cells. Disruption of PDGF signaling in the embryo leads to morphogenetic defects and embryonic or perinatal lethality. Tissues that are particularly susceptible to the absence of PDGF signaling are migrating mesoderm cells during gastrulation, nonneuronal neural crest cell derivatives, and kidney mesangial cells. These tissues share the common feature of undergoing epithelial-mesenchymal transitions. We review current knowledge of the distribution of PDGF ligands and receptors and discuss how this distribution may relate to several roles for PDGF during embryogenesis, particularly the regulation of mesenchymal cell behavior.
authors.affiliation: Department of Cell Biology, Harvard Medical School, Boston Massachusetts 02115, USA.
authors.forename: P
authors.initials: P
authors.lastname: Ataliotis
authors.forename: M
authors.initials: M
authors.lastname: Mercola
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D002465:Cell Movement; D004622:Embryo, Mammalian / Q000378:metabolism*; D005314:Embryonic and Fetal Development; D005260:Female; D005333:Fetus / Q000378:metabolism*; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D051379:Mice; D010982:Platelet-Derived Growth Factor / Q000032:analysis / Q000378:metabolism*; D011247:Pregnancy; D051381:Rats; D017479:Receptors, Platelet-Derived Growth Factor / Q000032:analysis / Q000378:metabolism*
chemical_list: D010982:Platelet-Derived Growth Factor; D017479:Receptors, Platelet-Derived Growth Factor