The complete primary structure of Cw*1701 reveals a highly divergent HLA class I molecule.
Genotyping of the HLA-C locus by PCR-SSP has previously shown 100% association of B41 and B42 with a new allelic variant. Partial sequencing studies (exons 2-4) demonstrated that this PCR-SSP variant corresponded to the new allele Cw*1701. In this study we have characterized the whole coding region of Cw*1701 from a Bubi individual of Equatorial Guinea. Our results partially confirm the previously reported sequence and reveal that Cw*1701 has many new polymorphisms at several exons, including a 18-bp insertion in exon 5. Cw*1701 is thus a most unusual HLA-C molecule defining a third allelic lineage of this locus.
Herrero
M J
MJ
Servicio de Inmunología, Clínica Puerta de Híerro, Madrid, Spain.
Vilches
C
C
de Pablo
R
R
Puente
S
S
Kreisler
M
M
D000595:Amino Acid Sequence; D001483:Base Sequence; D018076:DNA, Complementary; D015236:HLA-C Antigens / Q000235:genetics*; D008969:Molecular Sequence Data; D017386:Sequence Homology, Amino Acid; D012689:Sequence Homology, Nucleic Acid
D018076:DNA, Complementary; D015236:HLA-C Antigens