Long-term exercise patterns and immune function in healthy older women. A report of preliminary findings.
The purpose of this study was to examine the relationship between active versus inactive lifestyle and immunocompetence in older women. A sample of 46 independently dwelling, ambulatory and mentally alert women 60-98 years was examined, 25 who rated themselves as 'active' and 21 who rated themselves as 'inactive'. Lymphocyte subpopulations were analyzed by flow cytometry using selected monoclonal antibodies. The self-reported active subjects (also validated by their current unsolicited participation in a formal exercise class) demonstrated significantly higher percent change in CD25 mitogen stimulated lymphocytes (P = 0.0335) than those who reported themselves to be sedentary.
Gueldner
S H
SH
School of Nursing, Pennsylvania State University, University Park 16802, USA.
Poon
L W
LW
La Via
M
M
Virella
G
G
Michel
Y
Y
Bramlett
M H
MH
Noble
C A
CA
Paulling
E
E
D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000276:immunology*; D000911:Antibodies, Monoclonal; D015703:Antigens, CD / Q000096:biosynthesis; D015444:Exercise; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D008019:Life Style; D008213:Lymphocyte Activation; D015375:Receptors, Interleukin-2 / Q000096:biosynthesis; D016176:T-Lymphocyte Subsets / Q000276:immunology*
D000911:Antibodies, Monoclonal; D015703:Antigens, CD; D015375:Receptors, Interleukin-2