title: Slice location dependence of aortic regurgitation measurements with MR phase velocity mapping.
abstract: Although several methods have been used clinically to assess aortic regurgitation (AR), there is no "gold standard" for regurgitant volume measurement. Magnetic resonance phase velocity mapping (PVM) can be used for noninvasive blood flow measurements. To evaluate the accuracy of PVM in quantifying AR with a single imaging slice in the ascending aorta, in vitro experiments were performed by using a compliant aortic model. Attention was focused on determining the slice location that provided the best results. The most accurate measurements were taken between the aortic valve annulus and the coronary ostia where the measured (Y) and actual (X) flow rate had close agreement (Y = 0.954 x + 0.126, r2 = 0.995, standard deviation of error = 0.139 L/min). Beyond the coronary ostia, coronary flow and aortic compliance negatively affected the accuracy of the measurements. In vivo measurements taken on patients with AR showed the same tendency with the in vitro results. In making decisions regarding patient treatment, diagnostic accuracy is very important. The results from this study suggest that higher accuracy is achieved by placing the slice between the aortic valve and the coronary ostia and that this is the region where attention should be focused for further clinical investigation.
authors.affiliation: Cardiovascular Fluid Mechanics Laboratory, School of Chemical Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332-0100, USA.
authors.forename: G P
authors.initials: GP
authors.lastname: Chatzimavroudis
authors.forename: P G
authors.initials: PG
authors.lastname: Walker
authors.forename: J N
authors.initials: JN
authors.lastname: Oshinski
authors.forename: R H
authors.initials: RH
authors.lastname: Franch
authors.forename: R I
authors.initials: RI
authors.lastname: Pettigrew
authors.forename: A P
authors.initials: AP
authors.lastname: Yoganathan
mesh_terms: D001011:Aorta / Q000473:pathology; D001021:Aortic Valve / Q000473:pathology; D001022:Aortic Valve Insufficiency / Q000150:complications / Q000473:pathology / Q000503:physiopathology*; D001783:Blood Flow Velocity / Q000502:physiology*; D003187:Compliance; D003331:Coronary Vessels / Q000473:pathology / Q000503:physiopathology; D017352:Echo-Planar Imaging / Q000379:methods*; D006801:Humans; D015588:Observer Variation; D019047:Phantoms, Imaging; D018487:Ventricular Dysfunction, Left / Q000209:etiology / Q000473:pathology / Q000503:physiopathology