Enantioselective accumulation of (--)-pinoresinol through O-demethylation of (+/-)-eudesmin by Aspergillus niger.
Microbial transformation of (+/-)-eudesmin by Aspergillus niger was investigated. Enantioselective accumulation of (--)-pinoresinol was shown through O-demethylation of (+/-)-eudesmin. This fungus O- demethylated both enantiomers of eudesmin, but the conversion rates for each enantiomer were clearly different.
Kasahara
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Department of Applied Chemistry, Faculty of Science and Engineering, Kinki University, Kowakae, Osaka, Japan.
Miyazawa
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Kameoka
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H
D001234:Aspergillus niger / Q000378:metabolism*; D001711:Biotransformation; D005663:Furans / Q000378:metabolism / Q000493:pharmacokinetics*; D017705:Lignans; D008745:Methylation; D013237:Stereoisomerism
D005663:Furans; D017705:Lignans; C105875:eudesmin; C103298:pinoresinol