Clinical significance of soluble interleukin-2 receptor.
The measurement of soluble interleukin-2 receptor in serum has been shown to be useful in a variety of clinical conditions. In autoimmune disorders sIL-2R level correlates with the disease activity and reflects in-vivo immune system activation. Markedly elevated sIL-2R levels were found in certain hematologic malignancies such as adult T-cell leukemia and hairy cell leukemia. In hairy cell leukemia it reflects the tumor burden and response to therapy and can be used as a reliable non-invasive marker of disease activity. The sIL-2R levels at diagnosis predict reliably prognosis in non-Hodgkin lymphoma and in Hodgkin's disease.
Chrobák
L
L
1st Department of Medicine Charles University Faculty of Medicine.
D001327:Autoimmune Diseases / Q000175:diagnosis; D015415:Biomarkers / Q000097:blood*; D006084:Graft Rejection / Q000175:diagnosis; D019337:Hematologic Neoplasms / Q000175:diagnosis; D006801:Humans; D015375:Receptors, Interleukin-2 / Q000097:blood*; D012995:Solubility
D015415:Biomarkers; D015375:Receptors, Interleukin-2