[Bilateral leg ulcers with pathologic evidence of small vessel vasculitis by skin biopsy during hydroxyurea therapy of chronic myelogenous leukemia].
We report a 45-year-old male with chronic myelogenous leukemia (CML) who experienced skin ulcers of the left lateral malleolus and dorsum of both feet. He had been treated with hydroxyurea (HU) for 2 years. His leg ulcers improved after HU was discontinued. Skin biopsy of the ulcerated lesion revealed that the lesion is compatible with small vessel vasculitis, but circulating immune complexes (C1q, anti-C3d antibody) were negative. Although the precise mechanism of the skin ulcer is unknown, we must take into consideration the skin changes were secondary to hydroxyurea therapy in myeloproliferative disorders.
Tomiyama
J
J
Department of Internal Medicine, Tokyo Metropolitan Bokuto General Hospital.
Yano
K
K
Uchino
S
S
Ito
T
T
Kudo
H
H
Irimajiri
J
J
Ohkubo
H
H
Kanazawa
A
A
Kawahara
Y
Y
D000970:Antineoplastic Agents / Q000009:adverse effects*; D001706:Biopsy; D006801:Humans; D006918:Hydroxyurea / Q000009:adverse effects*; D007871:Leg Ulcer / Q000139:chemically induced* / Q000473:pathology; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D012867:Skin / Q000098:blood supply / Q000473:pathology*; D014657:Vasculitis / Q000139:chemically induced* / Q000473:pathology
D000970:Antineoplastic Agents; D006918:Hydroxyurea