title: Comparison of immunofiltration assay of plasma D-dimer with diagnostic imaging in deep vein thrombosis.
abstract: This prospective study was designed to assess the diagnostic sensitivity, specificity and negative predictive value of the NycoCard D-dimer plasma immunofiltration assay in patients with suspected deep vein thrombosis (DVT) confirmed by ultrasonography/venography. 84 medical patients were recruited: 43 patients (51%) had proven venous thrombosis, 33 by venography and 10 by ultrasonography. The sensitivity of NycoCard D-dimer in patients with DVT was 95.3%, the specificity was 22.0% and the negative predictive value was 81.8%. An algorithm including the NycoCard D-dimer test for the acute management of DVT is proposed. This would enable low-risk patients to be discharged early from hospital, without imaging or anticoagulant therapy.
authors.affiliation: Department of Haematology, St Helier NHS Trust, Surrey.
authors.forename: S B
authors.initials: SB
authors.lastname: Killick
authors.forename: P G
authors.initials: PG
authors.lastname: Pentek
authors.forename: J E
authors.initials: JE
authors.lastname: Mercieca
authors.forename: M F
authors.initials: MF
authors.lastname: Clarke
authors.forename: D H
authors.initials: DH
authors.lastname: Bevan
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000933:Antifibrinolytic Agents / Q000032:analysis*; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis*; D005374:Filtration; D006801:Humans; D007118:Immunoassay / Q000379:methods* / Q000592:standards; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011859:Radiography; D012680:Sensitivity and Specificity; D013924:Thrombophlebitis / Q000175:diagnosis* / Q000000981:diagnostic imaging; D014463:Ultrasonography
chemical_list: D000933:Antifibrinolytic Agents; D005338:Fibrin Fibrinogen Degradation Products; C036309:fibrin fragment D