[Role of the thymus and normal microbial flora on plasma fibronectin concentration in mice treated with immunomodulatory drugs].
The plasma fibronectin (pFN) concentration (cc)-determined by electro-immunodiffusion method-of untreated genetically or artificially athymic mice, or treated with TP-4 (thymus hormone sequence analog synthetic preparation) showed no significant difference from their euthymic or untreated controls. In contrast, the pFN cc in mice with different microbiological state showed significant alterations; the highest level occurred in conventional mice. The lower level in germfree mice was increased by bacterial monocontamination. The alternation from SPF into conventional state in athymic mice or treatment of athymic and euthymic mice with Bordetella pertussis vaccine also resulted in the increase of the pFN cc. Based on these and earlier results, it was assumed that the pFN cc is independent from the presence or absence of the thymus, but it depends on the actual microbiological state of the macroorganism.
Anderlik
P
P
Semmelweis Orvostudományi Egyetem, Mikrobiológiai Intézet, Budapest.
Antmann
K
K
Cseh
K
K
Kalabay
L
L
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D005353:Fibronectins / Q000097:blood*; D005856:Germ-Free Life; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D010446:Peptide Fragments / Q000494:pharmacology*; D010567:Pertussis Vaccine / Q000276:immunology*; D013946:Thymopoietins / Q000494:pharmacology*; D013950:Thymus Gland / Q000276:immunology / Q000502:physiology*
D000276:Adjuvants, Immunologic; D005353:Fibronectins; D010446:Peptide Fragments; D010567:Pertussis Vaccine; D013946:Thymopoietins; C045802:thymocartin
A thymus és a mikrobaflóra plazma fibronektin szintet befolyásoló szerepének vizsgálata immunmoduláns készítményekkel kezelt egerekben.