title: Prolonged duration of standing up is an early dopa-sensitive abnormality in Parkinson's disease.
abstract: We studied the influence of dopaminergic medication on the duration of standing up, static posture and gait in five patients with Parkinson's disease (Hoehn and Yahr stage 1.5 to 3) and four healthy controls, using an optoelectronic camera system. Duration of standing up was prolonged in patients, while static posture and gait were largely unaffected. The prolonged duration of standing up was corrected by dopaminergic medication. These results suggest that an increased duration of standing up is a relatively early and dopa-sensitive abnormality in Parkinson's disease.
authors.affiliation: Department of Neurology, Leiden University Hospital, The Netherlands.
authors.forename: B R
authors.initials: BR
authors.lastname: Bloem
authors.forename: K I
authors.initials: KI
authors.lastname: Roon
authors.forename: N J
authors.initials: NJ
authors.lastname: Delleman
authors.forename: J G
authors.initials: JG
authors.lastname: van Dijk
authors.forename: R A
authors.initials: RA
authors.lastname: Roos
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D015259:Dopamine Agents / Q000627:therapeutic use*; D004582:Electronics, Medical; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009068:Movement; D055095:Optics and Photonics / Q000295:instrumentation; D010300:Parkinson Disease / Q000188:drug therapy*; D010865:Pilot Projects; D011187:Posture / Q000502:physiology*; D013997:Time Factors
chemical_list: D015259:Dopamine Agents