title: Excitatory and trophic action of GABA and related substances in newborn mice and organotypic cerebellar culture.
abstract: Muscimol and diazepam produced an excitatory effect on the behavior of newborn mice instead of depression as in mature animals. In organotypic culture of mouse cerebellum, muscimol increased intracellular Ca2+ concentration and chronic application of bicuculline reduced number of Purkinje cells.
authors.affiliation: Laboratory of Neurochemistry, National Institute of Physiological Sciences, Okazaki, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Obata
mesh_terms: D000375:Aging / Q000502:physiology; D000818:Animals; D000831:Animals, Newborn / Q000254:growth & development / Q000502:physiology*; D001640:Bicuculline / Q000494:pharmacology; D002118:Calcium / Q000378:metabolism; D002452:Cell Count / Q000187:drug effects; D002531:Cerebellum / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D003975:Diazepam / Q000494:pharmacology; D018682:GABA Agents / Q000494:pharmacology*; D018755:GABA Agonists / Q000494:pharmacology; D018756:GABA Antagonists / Q000494:pharmacology; D018757:GABA Modulators / Q000494:pharmacology; D007425:Intracellular Membranes / Q000378:metabolism; D051379:Mice; D008813:Mice, Inbred ICR; D009043:Motor Activity / Q000187:drug effects*; D009118:Muscimol / Q000494:pharmacology; D009924:Organ Culture Techniques; D011689:Purkinje Cells / Q000166:cytology / Q000502:physiology; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology*
chemical_list: D018682:GABA Agents; D018755:GABA Agonists; D018756:GABA Antagonists; D018757:GABA Modulators; D009118:Muscimol; D005680:gamma-Aminobutyric Acid; D003975:Diazepam; D002118:Calcium; D001640:Bicuculline