[The effect of the prodigiozan stimulation of Kupffer cells on the development of perisinusoidal fibrosis in experimental hypervitaminosis A].
Perisinusoidal fibrosis development in experimental hypervitaminosis A and its combination with preliminary Kupffer cells stimulation with prodigiozan was studied in rat liver using light and electron microscopy. Reticular fibers volume density naturally growing after administration of large dozes of vitamin A, significantly reduces in appropriate terms of experiment after Kupffer cells stimulation with prodigiozan. Two cell type were distinguished in perisinusoidal space: typical fat-accumulating ones and fibroblast-like ones topographically closely connected with reticuline fibres. Endotheliocytes and Kupffer cells acquire dystrophic changes in prodigiozan introduction and hypervitaminosis A combination.
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D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004224:Diterpenes; D005260:Female; D006986:Hypervitaminosis A / Q000139:chemically induced* / Q000473:pathology; D007728:Kupffer Cells / Q000187:drug effects* / Q000473:pathology; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D008106:Liver Cirrhosis, Experimental / Q000139:chemically induced* / Q000473:pathology; D008854:Microscopy, Electron; D011354:Prodigiozan / Q000494:pharmacology*; D051381:Rats; D000084562:Retinyl Esters; D013268:Stimulation, Chemical; D013997:Time Factors; D014801:Vitamin A / Q000008:administration & dosage / Q000031:analogs & derivatives
D000900:Anti-Bacterial Agents; D004224:Diterpenes; D000084562:Retinyl Esters; D014801:Vitamin A; C009166:retinol acetate; D011354:Prodigiozan
Vliianie stimulirovaniia kletok Kupfera prodigiozanom na razvitie perisinusoidal'nogo fibroza pri éksperimental'nom gipervitaminoze A.