title: The human gene encoding FKBP-rapamycin associated protein (FRAP) maps to chromosomal band 1p36.2.
abstract: FKBP-rapamycin associated protein (FRAP) is a phosphatidylinositol kinase (PIK)-related kinase implicated in the inhibition of progression through G1 of the cell cycle. The PIK-related kinases are a growing family of proteins involved in cell-cycle checkpoints, DNA repair and recombination. We have mapped the human FRAP gene to chromosome 1p36.2, a region consistently deleted in neuroblastomas.
authors.affiliation: Molecular Medicine Unit, University of Leeds, St. James's University Hospital, UK. desnl@stjames.leeds.ac.uk
authors.forename: N J
authors.initials: NJ
authors.lastname: Lench
authors.forename: R
authors.initials: R
authors.lastname: Macadam
authors.forename: A F
authors.initials: AF
authors.lastname: Markham
mesh_terms: D001483:Base Sequence; D002352:Carrier Proteins / Q000235:genetics; D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1; D006801:Humans; D020104:Immunophilins; D017404:In Situ Hybridization, Fluorescence; D008969:Molecular Sequence Data; D017853:Phosphotransferases (Alcohol Group Acceptor); D058570:TOR Serine-Threonine Kinases
chemical_list: D002352:Carrier Proteins; D017853:Phosphotransferases (Alcohol Group Acceptor); C546842:MTOR protein, human; D058570:TOR Serine-Threonine Kinases; D020104:Immunophilins