title: Response of choriocarcinoma to paclitaxel. Case report and review of resistance.
abstract: Paclitaxel has been reported to inhibit proliferation and to promote differentiation of choriocarcinoma cells. We report a case of a patient with high risk trophoblastic disease who had remission with paclitaxel. The mechanisms of paclitaxel resistance are reviewed.
authors.affiliation: Unidad de Quimioterapia, Hospital General de Mexico, Mexico, D.F.
authors.forename: R
authors.initials: R
authors.lastname: Gerson
authors.forename: A
authors.initials: A
authors.lastname: Serrano
authors.forename: M
authors.initials: M
authors.lastname: Del Carmen Bello
authors.forename: M
authors.initials: M
authors.lastname: Lazaro
authors.forename: A P
authors.initials: AP
authors.lastname: Kudelka
authors.forename: J J
authors.initials: JJ
authors.lastname: Kavanagh
mesh_terms: D000328:Adult; D000972:Antineoplastic Agents, Phytogenic / Q000627:therapeutic use*; D002822:Choriocarcinoma / Q000188:drug therapy*; D019008:Drug Resistance, Neoplasm; D005260:Female; D006801:Humans; D017239:Paclitaxel / Q000627:therapeutic use*; D011247:Pregnancy; D014328:Trophoblastic Neoplasms / Q000188:drug therapy*; D014594:Uterine Neoplasms / Q000188:drug therapy*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D017239:Paclitaxel