[Rhythmic circulatory dysregulation in stiff man syndrome].
A woman with severe stiff-man syndrome showed periodic cardiovascular dysregulation. The blood pressure changed spontaneously every 5-10 min. This rhythm was also maintained after relaxation. However, the vegetative and motoric disturbances disappeared after intrathecal application of baclofen. It is speculated that spinal GABAergic mechanisms are responsible for the tonic regulation of the cardiovascular system.
Diedrich
U
U
Neurologische Universitätsklinik, Göttingen.
D001341:Autonomic Nervous System / Q000187:drug effects / Q000503:physiopathology; D001418:Baclofen / Q000008:administration & dosage; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D002319:Cardiovascular System / Q000294:innervation; D005260:Female; D018755:GABA Agonists / Q000008:administration & dosage; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology; D006439:Hemodynamics / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D007278:Injections, Spinal; D008875:Middle Aged; D013116:Spinal Cord / Q000187:drug effects / Q000503:physiopathology; D016750:Stiff-Person Syndrome / Q000188:drug therapy / Q000503:physiopathology*; D005680:gamma-Aminobutyric Acid / Q000502:physiology
D018755:GABA Agonists; D005680:gamma-Aminobutyric Acid; D001418:Baclofen
Rhythmische Kreislaufdysregulation bei Stiff-man-Syndrom.