Plasma deoxycholic acid is related to deoxycholic acid in faecal water.
Bile acids are considered as a risk factor for colorectal carcinogenesis. They were analysed in samples of faecal water and plasma of fasting heparine blood from 23 urolithiasis patients. Linear regression showed that the highest percentage of variance (52%) was explained by the model: plasma deoxycholic acid (micromol/l) = -3.11 + 0.96(+/-0.25*) 10log deoxycholic acid in faecal water (micromol/l) + 0.35(+/-0.15*) pH of faecal water -0.41(+/-0.19#) defacation frequency (number of stools/day); *P < 0.05, #P = 0.055. In future studies, analysing blood levels of unconjugated deoxycholic acid may substitute faecal measurements.
van Faassen
A
A
Department of Urology, University Hospital, Maastricht, The Netherlands.
Ochsenkühn
T
T
Houterman
S
S
van der Ploeg
E M
EM
Bueno-de-Mesquita
B H
BH
Ocké
M C
MC
Bayerdörffer
E
E
Janknegt
R A
RA
D002756:Cholagogues and Choleretics / Q000032:analysis*; D003840:Deoxycholic Acid / Q000032:analysis* / Q000097:blood; D005243:Feces / Q000737:chemistry*; D006801:Humans
D002756:Cholagogues and Choleretics; D003840:Deoxycholic Acid