title: Development of invasive adenocarcinoma in a long-standing Kock continent ileostomy: report of a case.
abstract: The first case of adenocarcinoma developing in a continent ileostomy is reported. A healthy, 39-year-old man with a continent ileostomy for 17 years developed subacute obstructive symptoms and was found on endoscopy to have a large adenocarcinoma involving the intussusception valve. At operation, he was found to have a large tumor originating in the valve, extending through the reservoir, and involving the afferent ileal limb. A number of metastatic lymph nodes were identified in the mesentery of the small bowel. He underwent excision of the pouch and formation of an end ileostomy. He is currently undergoing adjuvant chemotherapy. Biochemical and morphologic changes in the ileal pouch, both in the pelvis and the continent ileostomy, are discussed. The implications of this apparent de novo cancer arising in an ileal pouch are discussed.
authors.affiliation: Division of Colon and Rectal Surgery, University of Texas Health Science Center, Houston, USA.
authors.forename: C L
authors.initials: CL
authors.lastname: Cox
authors.forename: D R
authors.initials: DR
authors.lastname: Butts
authors.forename: M P
authors.initials: MP
authors.lastname: Roberts
authors.forename: R A
authors.initials: RA
authors.lastname: Wessels
authors.forename: H R
authors.initials: HR
authors.lastname: Bailey
mesh_terms: D000230:Adenocarcinoma / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D000328:Adult; D000782:Aneuploidy; D003093:Colitis, Ulcerative / Q000601:surgery; D004273:DNA, Neoplasm / Q000032:analysis; D005434:Flow Cytometry; D006801:Humans; D007078:Ileal Neoplasms / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D007080:Ileocecal Valve; D008297:Male; D008940:Mitotic Index; D016737:Proctocolectomy, Restorative / Q000009:adverse effects*
chemical_list: D004273:DNA, Neoplasm