title: A hepatic graft tuberculosis transmitted from a living-related donor.
abstract: Exclusion of occult diseases in the donor organ and prevention of infectious disease transmission are minimal requirements in organ transplantation. We report here a case of hepatic graft tuberculosis, which was most likely transmitted by the graft from the living-related donor. The course of the recipient included tuberculosis, rejection, and other infections, which led to vanishing bile duct syndrome. Due to various infections and tuberculosis, as well as a strong interaction between rifampicin and tacrolimus, the patient died of pneumonia on day 273 after transplantation. This case emphasizes the importance of care in the selection of a living-related donor for liver transplantation.
authors.affiliation: Department of Transplant Surgery, Kyoto University Faculty of Medicine, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Kiuchi
authors.forename: Y
authors.initials: Y
authors.lastname: Inomata
authors.forename: S
authors.initials: S
authors.lastname: Uemoto
authors.forename: K
authors.initials: K
authors.lastname: Satomura
authors.forename: H
authors.initials: H
authors.lastname: Egawa
authors.forename: H
authors.initials: H
authors.lastname: Okajima
authors.forename: Y
authors.initials: Y
authors.lastname: Yamaoka
authors.forename: K
authors.initials: K
authors.lastname: Tanaka
mesh_terms: D000328:Adult; D004347:Drug Interactions; D017809:Fatal Outcome; D005260:Female; D005500:Follow-Up Studies; D006084:Graft Rejection; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000627:therapeutic use; D007223:Infant; D008107:Liver Diseases; D008111:Liver Function Tests; D016031:Liver Transplantation / Q000502:physiology; D019520:Living Donors; D009035:Mothers; D011183:Postoperative Complications; D012293:Rifampin / Q000009:adverse effects / Q000627:therapeutic use; D016559:Tacrolimus / Q000009:adverse effects / Q000627:therapeutic use; D014376:Tuberculosis / Q000635:transmission*
chemical_list: D007166:Immunosuppressive Agents; D012293:Rifampin; D016559:Tacrolimus