The roles of gamma 1 heavy chain membrane expression and cytoplasmic tail in IgG1 responses.
In antibody responses, B cells switch from the expression of immunoglobulin (Ig) mu and delta heavy (H) chains to that of other Ig classes (alpha, gamma, or epsilon), each with a distinct effector function. Membrane-bound forms of alpha, gamma, and epsilon, but not mu and delta, have highly conserved cytoplasmic tails. Mutant mice unable to express membrane gamma1 H chains or producing tailless gamma1 H chains failed to generate efficient IgG1 responses and IgG1 memory. H chain membrane expression after class switching is thus required for these functions, and class switching equips the B cell antigen receptor with a regulatory cytoplasmic tail that naïve B cells lack.
Kaisho
T
T
Institute for Genetics, University of Cologne, Weyertal 121, D-50931 Cologne, Germany. tkaisho@home.hyo-med.ac.jp
Schwenk
F
F
Rajewsky
K
K
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D003593:Cytoplasm; D018390:Gene Targeting; D007114:Immunization; D017578:Immunoglobulin Class Switching; D007074:Immunoglobulin G / Q000096:biosynthesis / Q000097:blood / Q000276:immunology*; D007142:Immunoglobulin gamma-Chains / Q000737:chemistry / Q000235:genetics / Q000276:immunology*; D007156:Immunologic Memory; D051379:Mice; D009154:Mutation; D011947:Receptors, Antigen, B-Cell / Q000737:chemistry / Q000235:genetics / Q000276:immunology*
D007074:Immunoglobulin G; D007142:Immunoglobulin gamma-Chains; D011947:Receptors, Antigen, B-Cell