title: A prospective randomized study of three types of platelet concentrates in patients with haematological malignancy: corrected platelet count increments and frequency of nonhaemolytic febrile transfusion reactions.
abstract: We prospectively randomized 51 patients with haematological malignancy requiring platelet concentrates (PCs) to receive either single donor platelet-pheresis products (SD-PC), PCs made from pooled buffy coats (BC-PC) or pooled units of platelets made by the platelet-rich plasma method (PRP-PC). The leucocyte content of each type of PC was 0.33 (0.03-13.5), 5.68 (0.19-99.0) and 365 (65-910) x 10(6); median (range), respectively; P < 0.0001. All red cell transfusions were leucodepleted by filtration. Statistical comparison of the probability of the occurrence of a nonhaemolytic febrile transfusion reaction (NHFTR) following transfusion of PCs in patients in each group showed a significant decrease for the SD-PC and BC-PC groups (0.031 and 0.038, respectively) when compared with PRP-PC (0.171); P = 0.0001. The actual corrected platelet count increments (CCI) at 1-6 and 18-24 h post-transfusion for all three types of PC did not differ significantly. We conclude that transfusion of PRP-PC is associated with a significant increase in NHFTR.
authors.affiliation: National Blood Service, South-west Centre, Bristol, UK.
authors.forename: N A
authors.initials: NA
authors.lastname: Anderson
authors.forename: S
authors.initials: S
authors.lastname: Gray
authors.forename: J A
authors.initials: JA
authors.lastname: Copplestone
authors.forename: D C
authors.initials: DC
authors.lastname: Chan
authors.forename: M
authors.initials: M
authors.lastname: Hamon
authors.forename: A G
authors.initials: AG
authors.lastname: Prentice
authors.forename: S A
authors.initials: SA
authors.lastname: Johnson
authors.forename: M
authors.initials: M
authors.lastname: Phillips
authors.forename: G
authors.initials: G
authors.lastname: van Waeg
authors.forename: A
authors.initials: A
authors.lastname: Oakhill
authors.forename: S
authors.initials: S
authors.lastname: Abeyasekera
authors.forename: D H
authors.initials: DH
authors.lastname: Pamphilon
mesh_terms: D000328:Adult; D005260:Female; D019337:Hematologic Neoplasms / Q000150:complications*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010976:Platelet Count; D017713:Platelet Transfusion / Q000009:adverse effects / Q000379:methods*; D011446:Prospective Studies; D013921:Thrombocytopenia / Q000209:etiology / Q000628:therapy*