Lipoprotein glomerulopathy: a pediatric case report.
We report an 8-year-old girl with lipoprotein glomerulopathy who may have developed this condition as young as 4 years of age. To our knowledge this is the youngest reported case of this disease. Lipid studies of the patient and her family members revealed elevated concentrations of apolipoprotein E (apo E), the apo E phenotype E2/3, and the genotype E3/3. However, other families revealed no urinary abnormalities. Our findings suggest that an apo E abnormality may be responsible for the development of lipoprotein glomerulopathy. Genetic analysis of apo E is needed to clarify the pathogenesis.
Maruyama
K
K
Department of Pediatrics, Gunma University School of Medicine, Japan.
Arai
H
H
Ogawa
T
T
Tomizawa
S
S
Morikawa
A
A
D001053:Apolipoproteins / Q000097:blood; D001057:Apolipoproteins E / Q000097:blood / Q000235:genetics; D002648:Child; D005260:Female; D006801:Humans; D007668:Kidney / Q000473:pathology; D007674:Kidney Diseases / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D008074:Lipoproteins / Q000097:blood / Q000378:metabolism*; D010641:Phenotype
D001053:Apolipoproteins; D001057:Apolipoproteins E; D008074:Lipoproteins