title: A novel human complement component C7 phenotype detected in South Africa and proposed designation of the allele as C7*10.
abstract: A novel allotype of the seventh component of human complement was detected by isoelectric focusing. The band pattern showed a complete band-interval shift towards the cathode compared with the C7 1 allotype and it is proposed that the designation is C7 10. The allele C7*10 segregated in two South African Cape Coloured families and had a gene frequency of 0.006. It was also found to segregate together with a C6*rare allele.
authors.affiliation: Molecular Immunopathology Unit, MRC Centre, Cambridge, UK.
authors.forename: A
authors.initials: A
authors.lastname: Orren
authors.forename: R
authors.initials: R
authors.lastname: Würzner
authors.forename: P J
authors.initials: PJ
authors.lastname: Lachmann
authors.forename: M J
authors.initials: MJ
authors.lastname: Hobart
mesh_terms: D000483:Alleles; D003184:Complement C7 / Q000145:classification / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D010375:Pedigree; D010641:Phenotype; D013019:South Africa
chemical_list: D003184:Complement C7