High resolution imaging of native biological sample surfaces using scanning probe microscopy.
The possibility of acquiring high resolution topographs using scanning probe microscopes under physiological conditions allows the observation of biomolecules at work. Progress has recently been made in imaging protein-DNA complexes, individual oligomers and protein arrays. Scanning probe microscopes are now tools that complement X-ray crystallography and electron microscopy.
Engel
A
A
ME Müller Institute for Structural Biology, Biozentrum, Klingelbergstr 70, CH-4056, Basel, Switzerland. aengel@ubaclu.unibas.ch
Schoenenberger
C A
CA
Müller
D J
DJ
D001425:Bacterial Outer Membrane Proteins / Q000648:ultrastructure; D018360:Crystallography, X-Ray; D004247:DNA / Q000648:ultrastructure*; D004268:DNA-Binding Proteins / Q000648:ultrastructure*; D046911:Macromolecular Substances; D008853:Microscopy / Q000295:instrumentation / Q000379:methods*; D008854:Microscopy, Electron; D010957:Plasmids; D011487:Protein Conformation; D013499:Surface Properties
D001425:Bacterial Outer Membrane Proteins; D004268:DNA-Binding Proteins; D046911:Macromolecular Substances; D004247:DNA