Further studies of the role of hippocampal synaptic plasticity in spatial learning: is hippocampal LTP a mechanism for automatically recording attended experience?
Rats trained as normal animals on a delayed matching-to-place task until they were fully familiar with the environment and the strategy required for effective performance were treated with a CSF or D-AP5 at a dose shown to be sufficient to block LTP in vivo. A striking delay-dependent impairment was observed in the AP5-treated animals. These findings indicate that 1-trial event memory depends on NMDA receptors.
Morris
R G
RG
Department of Pharmacology, University of Edinburgh, UK.
D015763:2-Amino-5-phosphonovalerate / Q000494:pharmacology; D000818:Animals; D006624:Hippocampus / Q000502:physiology*; D017774:Long-Term Potentiation / Q000187:drug effects; D018782:Maze Learning / Q000187:drug effects / Q000502:physiology*; D008568:Memory / Q000502:physiology*; D009473:Neuronal Plasticity; D051381:Rats; D013028:Space Perception / Q000502:physiology; D013569:Synapses / Q000187:drug effects / Q000502:physiology*; D013997:Time Factors
D015763:2-Amino-5-phosphonovalerate