Effect of antiorthostatic hypokinetic/hypodynamia on urinary endothelin-1 and N-acetyl-beta-D-glucosaminidase excretion in rats.
In an experimental model with rats in head-down suspension, plasma levels and urinary excretion of endothelin-1 (ET-1) and urinary excretion of N-acetyl-beta-D-glucosaminidase (EC 3.2.1.30; NAG) were determined. Significant variations in time in the effective plasma ET-1 levels in the superior and inferior cava vessel blood of animals maintained for 6 days in hypogravity with respect to controls were observed. We not only found a transient increase in urinary NAG activity but also that the levels of U-ET-1 increased during head-down suspension. The simultaneous evaluation at urinary level of these two parameters could be an indication that there are different sites of renal parenchymal involvement or injury during antiorthostatic hypokinesis.
Capodicasa
E
E
Istituto di Medicina Interna e Scienze Oncologiche, Università di Perugia, Italy.
Tassi
C
C
Rossi
R
R
Mezzasoma
L
L
Valiani
M
M
Biondi
R
R
D000118:Acetylglucosaminidase / Q000652:urine*; D000818:Animals; D003345:Corticosterone / Q000097:blood; D003404:Creatinine / Q000652:urine; D019332:Endothelin-1 / Q000097:blood / Q000378:metabolism* / Q000652:urine; D016232:Endothelins / Q000378:metabolism; D018475:Head-Down Tilt / Q000502:physiology*; D007103:Immobilization / Q000502:physiology*; D007668:Kidney / Q000378:metabolism*; D008297:Male; D011498:Protein Precursors / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley
D019332:Endothelin-1; D016232:Endothelins; D011498:Protein Precursors; D003404:Creatinine; D000118:Acetylglucosaminidase; D003345:Corticosterone