Active efflux of antimicrobial agents in wild-type strains of enterococci.
Enterococci are intrinsically resistant to numerous antimicrobial agents. We examined the energy-dependent efflux of radiolabeled drugs from four reference strains of Enterococcus faecalis and a strain of Enterococcus faecium and found that most strains pumped out norfloxacin and chloramphenicol. Efflux of tetracycline was detected only in certain strains.
Lynch
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C
Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA.
Courvalin
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Nikaido
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D000900:Anti-Bacterial Agents / Q000378:metabolism* / Q000494:pharmacology; D002701:Chloramphenicol / Q000378:metabolism / Q000494:pharmacology; D013293:Enterococcus faecalis / Q000187:drug effects / Q000378:metabolism*; D016984:Enterococcus faecium / Q000187:drug effects / Q000378:metabolism*; D008826:Microbial Sensitivity Tests; D009643:Norfloxacin / Q000378:metabolism / Q000494:pharmacology; D013752:Tetracycline / Q000378:metabolism / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D002701:Chloramphenicol; D013752:Tetracycline; D009643:Norfloxacin