title: [The effect of septic complications on recovery in acute renal insufficiency in patients with multiple injuries].
abstract: Septic complication in patients (pts) with ARF are among the most important causes of mortality, especially in pts with polytrauma and multiple-organ failure. Prevention procedures, early and accurate diagnosis and persistent treatment in time are necessary to avoid septic shock. During the period od 27 months (1992-1994), 25 pts with wounds inflicted in war and AFT were treated by haemodialysis. Eighteen (72%) pts had septic complication. Eleven (71%) of them recovered from ARF, while 7 (39%) pts died despite the undertaken procedures. Nine pts (81%) with septic complication and ARF who improved their renal function were treated by one or more nephrotoxic antibiotics. Haemodialysis was initiated when average BUN concentration was 35.7 mmol/l and plasma creatinine level about 0.8 mmol/l. Simultaneously with symptomatic and substituting therapy, and surgical correction of polytrauma, approximately 9 haemodialysis in the period of 21 day were necessary for ARF recovery. In the group of pts who had no improvement of renal function, 6 (85%) received 1 or more nephrotoxic drugs. Approximately 5 haemodialysis were done in these pts, in a shorter period of time. In polytraumatized pts with ARF with septic complication, factors which potentiate hypercatabolism aggravate the prognosis of ARF, increase mortality, require a greater number of haemodialysis and significantly prolong the recovery time of ARF.
authors.affiliation: Institute of Urology and Nephrology, Clinical Centre of Serbia, Belgrade.
authors.forename: V
authors.initials: V
authors.lastname: Ostrić
authors.forename: M
authors.initials: M
authors.lastname: Radović
authors.forename: M
authors.initials: M
authors.lastname: Korolija
authors.forename: Lj
authors.initials: Lj
authors.lastname: Djukanović
authors.forename: A
authors.initials: A
authors.lastname: Mladenović
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology / Q000401:mortality* / Q000628:therapy; D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D009102:Multiple Organ Failure / Q000209:etiology; D009104:Multiple Trauma / Q000150:complications*; D011379:Prognosis; D018805:Sepsis / Q000150:complications*
vernacular_title: Uticaj septickih komplikacija na oporavak akutne insuficijencije bubrega kod politraumatizovanih bolesnika.