Blastomycosis of the eyelid.
BACKGROUND
Published reports indicate that eyelid involvement occurs in approximately 25% of patients with systemic blastomycosis and that mortality exceeds 60% in untreated patients. The purpose of this study is to investigate this purportedly frequent association.


METHODS
The Medical Diagnostic index of the Mayo Clinic was used to identify patients who were treated for blastomycosis from 1976 through 1993. The medical records of affected patients were reviewed.


RESULTS
Of 79 patients with blastomycosis, only 1 (1.27%; 95% confidence interval, 0.03%-6.85%) had eyelid involvement. The diagnosis of systemic disease was established in this patient after biopsy of the eyelid lesion, and the infection responded satisfactorily to treatment with itraconazole.


CONCLUSIONS
Contrary to previous reports, eyelid involvement with systemic blastomycosis is uncommon.
Bartley
G B
GB
Department of Ophthalmology, Mayo Clinic, Rochester, MN 55905, USA.
D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use; D001758:Blastomyces / Q000302:isolation & purification; D001759:Blastomycosis / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D015821:Eye Infections, Fungal / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D005141:Eyelid Diseases / Q000188:drug therapy / Q000382:microbiology* / Q000473:pathology; D005143:Eyelids / Q000382:microbiology; D006801:Humans; D017964:Itraconazole / Q000627:therapeutic use; D008297:Male; D016896:Treatment Outcome
D000935:Antifungal Agents; D017964:Itraconazole