title: Diagnosis and management of canine cortisol-secreting adrenal tumors.
abstract: Cortisol-secreting adrenal tumors are responsible for 10% to 15% of all cases of naturally occurring canine hyperadrenocorticism. Differentiation of adrenal-dependent hyperadrenocorticism from pituitary-dependent hyperadrenocorticism is very important because the recommended therapeutic approaches for each are different, and the prognosis also may be different. A stepwise approach to diagnosing and staging the disease is needed. Treatment options include surgery and administration of mitotane or ketoconazole.
authors.affiliation: Boston Road Animal Hospital, Springfield, USA.
authors.forename: P P
authors.initials: PP
authors.lastname: Kintzer
authors.forename: M E
authors.initials: ME
authors.lastname: Peterson
mesh_terms: D000236:Adenoma / Q000175:diagnosis / Q000628:therapy / Q000662:veterinary*; D000310:Adrenal Gland Neoplasms / Q000175:diagnosis / Q000628:therapy / Q000662:veterinary*; D000311:Adrenal Glands / Q000187:drug effects / Q000601:surgery; D000324:Adrenocorticotropic Hormone / Q000097:blood; D000818:Animals; D000935:Antifungal Agents / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use; D004283:Dog Diseases / Q000175:diagnosis* / Q000378:metabolism / Q000628:therapy*; D004285:Dogs; D006854:Hydrocortisone / Q000097:blood / Q000378:metabolism*; D007654:Ketoconazole / Q000627:therapeutic use; D008939:Mitotane / Q000627:therapeutic use; D011379:Prognosis
chemical_list: D000935:Antifungal Agents; D000970:Antineoplastic Agents; D008939:Mitotane; D000324:Adrenocorticotropic Hormone; D007654:Ketoconazole; D006854:Hydrocortisone