X chromosome map at 75-kb STS resolution, revealing extremes of recombination and GC content.
A YAC/STS map of the X chromosome has reached an inter-STS resolution of 75 kb. The map density is sufficient to provide YACs or other large-insert clones that are cross-validated as sequencing substrates across the chromosome. Marker density also permits estimates of regional gene content and a detailed comparison of genetic and physical map distances. Five regions are detected with relatively high G + C, correlated with gene richness; and a 17-Mb region with very low recombination is revealed between the Xq13.3 [XIST] and Xq21.3 XY homology loci.
Nagaraja
R
R
Center for Genetics in Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
MacMillan
S
S
Kere
J
J
Jones
C
C
Griffin
S
S
Schmatz
M
M
Terrell
J
J
Shomaker
M
M
Jermak
C
C
Hott
C
C
Masisi
M
M
Mumm
S
S
Srivastava
A
A
Pilia
G
G
Featherstone
T
T
Mazzarella
R
R
Kesterson
S
S
McCauley
B
B
Railey
B
B
Burough
F
F
Nowotny
V
V
D'Urso
M
M
States
D
D
Brownstein
B
B
Schlessinger
D
D
D001482:Base Composition / Q000235:genetics; D002874:Chromosome Mapping / Q000379:methods; D018244:Chromosomes, Artificial, Yeast / Q000235:genetics; D003597:Cytosine Nucleotides / Q000235:genetics; D018076:DNA, Complementary / Q000235:genetics; D015870:Gene Expression / Q000235:genetics; D015698:Genomic Library; D006150:Guanine Nucleotides / Q000235:genetics; D006801:Humans; D016324:Sequence Tagged Sites; D014960:X Chromosome / Q000235:genetics*
D003597:Cytosine Nucleotides; D018076:DNA, Complementary; D006150:Guanine Nucleotides