title: Uniform irradiation of irregularly shaped cavities for photodynamic therapy.
abstract: It is difficult to achieve a uniform light distribution in irregularly shaped cavities. We have conducted a study on the use of hollow 'integrating' moulds for more uniform light delivery of photodynamic therapy in irregularly shaped cavities such as the oral cavity. Simple geometries such as a cubical box, a sphere, a cylinder and a 'bottle-neck' geometry have been investigated experimentally and the results have been compared with computed light distributions obtained using the 'radiosity method'. A high reflection coefficient of the mould and the best uniform direct irradiance possible on the inside of the mould were found to be important determinants for achieving a uniform light distribution.
authors.affiliation: Laser Centre, Academic Medical Centre, Amsterdam, The Netherlands.
authors.forename: A I
authors.initials: AI
authors.lastname: Rem
authors.forename: M J
authors.initials: MJ
authors.lastname: van Gemert
authors.forename: F W
authors.initials: FW
authors.lastname: van der Meulen
authors.forename: G H
authors.initials: GH
authors.lastname: Gijsbers
authors.forename: J F
authors.initials: JF
authors.lastname: Beek
mesh_terms: D006283:Health Physics / Q000379:methods; D008433:Mathematics; D008962:Models, Theoretical; D010778:Photochemotherapy / Q000379:methods*; D011879:Radiotherapy Dosage / Q000592:standards; D012542:Scattering, Radiation