Control of immunoglobulin gene rearrangements in developing B cells.
The antigen receptor on B lymphocytes is the product of a series of gene rearrangements which ends when a functional receptor gene is assembled. Recent work has shown that the receptor-associated molecules Ig alpha and Ig beta provide the signals that lead to inhibition of further recombination. Furthermore, Ig beta has been implicated in initiating the last step of the recombination reaction.
Papavasiliou
F
F
Laboratory of Molecular Immunology, Howard Hughes Medical Institute, Rockefeller University, New York, NY 10021, USA. papavaf@rockvax.rockefeller.edu
Jankovic
M
M
Gong
S
S
Nussenzweig
M C
MC
D000818:Animals; D001402:B-Lymphocytes / Q000502:physiology*; D015322:Gene Rearrangement, B-Lymphocyte / Q000502:physiology*; D006801:Humans; D051379:Mice; D011947:Receptors, Antigen, B-Cell / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology
D011947:Receptors, Antigen, B-Cell