Does angiotensin play a role in human fetal erythropoiesis?
Angiotensin affects the growth of many cell types and there have been suggestions that it could influence cells which respond to erythropoietin. During first trimester, human fetal haematopoietic cells are exquisitely responsive to erythropoietin and we have assessed the potential for angiotensin to also influence the growth of these cell types in a standard culture system. The data obtained from these studies indicate that angiotensin does not influence fetal haematopoiesis over a range of concentrations.
Anderson
E M
EM
Department of Immunology, Queen's medical Centre, Nottingham, UK.
Jones
D R
DR
Liu
D T
DT
Broughton Pipkin
F
F
D000804:Angiotensin II / Q000494:pharmacology*; D002478:Cells, Cultured; D004920:Erythropoiesis / Q000187:drug effects; D004921:Erythropoietin / Q000494:pharmacology; D005260:Female; D005333:Fetus; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D017228:Hepatocyte Growth Factor / Q000494:pharmacology; D006801:Humans; D008099:Liver / Q000166:cytology / Q000196:embryology* / Q000502:physiology; D011247:Pregnancy; D011261:Pregnancy Trimester, First
D004921:Erythropoietin; D000804:Angiotensin II; D017228:Hepatocyte Growth Factor