Activate NF-kappa B or die?
Activation of the transcription factor NF-kappaB has been linked to apoptosis, with the factor playing either an anti-apoptotic or a pro-apoptotic role, depending on the type of cell in which it is expressed.
Baichwal
V R
VR
Tularik Inc., South San Francisco, California 94080, USA. vijay@tularik.com
Baeuerle
P A
PA
D000818:Animals; D000970:Antineoplastic Agents / Q000633:toxicity; D017209:Apoptosis / Q000187:drug effects; D018698:Glutamic Acid / Q000633:toxicity; D006801:Humans; D008954:Models, Biological; D016328:NF-kappa B / Q000096:biosynthesis / Q000187:drug effects / Q000502:physiology*; D018124:Receptors, Tumor Necrosis Factor / Q000502:physiology
D000970:Antineoplastic Agents; D016328:NF-kappa B; D018124:Receptors, Tumor Necrosis Factor; D018698:Glutamic Acid