title: [Genetic organization of GBV-C].
abstract: Genome of GBV-C have 5' and 3' untranslated region and a coding region of 2842 amino acid. In comparison with other flaviviruses, GBV-C lacks the sequence coding typical CORE protein at the N terminus of putative polyprotein. In the putative structure region, E1 and E2, three potential glycosylation sites(Asn-X-Ser/Thr) were conserved in all isolates. In the putative NS3 region, conserved elements found in RNA helicases with nucleotide triphosphate(NTP) binding motif, GSGKS(residue 1097-1101) and DECH(residue 1184-1187), were observed. In addition, a sequence motif found in all viral RNA-dependent RNA polymerase, GDD(residue 2587-2589) was also conserved in NS5B region.
authors.affiliation: Diagnostic Division, Tonen Corporation.
authors.forename: K
authors.initials: K
authors.lastname: Yamaguchi
authors.forename: S
authors.initials: S
authors.lastname: Yagi
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D018067:Flaviviridae / Q000737:chemistry / Q000235:genetics*; D016679:Genome, Viral; D008969:Molecular Sequence Data; D012689:Sequence Homology, Nucleic Acid; D014158:Transcription, Genetic; D014764:Viral Proteins / Q000737:chemistry
chemical_list: D014764:Viral Proteins