Efficacy of two avian Salmonella-immune lymphokines against liver invasion in chickens by Salmonella serovars with different O-group antigens.
Newly hatched chicks are susceptible to organ invasion by various serovars of Salmonella. We have previously shown that intraperitoneal administration of Salmonella enteritidis-immune lymphokine (SEILK) increased resistance to organ invasion by S. enteritidis (SE) in day-of-hatch chicks. In the present study, we determined that Salmonella-immune lymphokines can provide protection against organ invasion by serovars that are unrelated to the original serovar used as an immunogen. Immune lymphokines were produced from the splenic T cells of mature hens immunized with either viable SE or Salmonella anatum (SA). Day-of-hatch chicks were treated with either SA-immune lymphokine (SAILK) or SEILK and challenged per os with either Salmonella typhimurium (ST) or SE 1 hr later. Liver samples were aseptically collected 20 hr later and were cultured to detect salmonella. We found that SAILK conferred resistance against invasion by either SE, a serogroup D organism, or ST, a serogroup B organism. Furthermore, SEILK reduced organ invasion by ST. These observations together reveal that the protection against organ invasion conferred by Salmonella-immune lymphokines is unrelated to the serovar-specific antigenic characteristics of the immunizing bacteria.
Ziprin
R L
RL
USDA, Agricultural Research Service, Food Animal Protection Research Laboratory, College Station, Texas 77845, USA.
Kogut
M H
MH
D000818:Animals; D002645:Chickens; D005260:Female; D007113:Immunity, Innate; D008099:Liver / Q000276:immunology* / Q000382:microbiology; D008222:Lymphokines / Q000096:biosynthesis* / Q000276:immunology; D019081:O Antigens / Q000276:immunology*; D012475:Salmonella / Q000276:immunology*; D012481:Salmonella Infections, Animal / Q000276:immunology*; D012477:Salmonella enteritidis / Q000276:immunology; D012486:Salmonella typhimurium / Q000276:immunology; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
D008222:Lymphokines; D019081:O Antigens