title: Dexamethasone, cyclophosphamide, idarubicin and etoposide (DC-IE): a novel, intensive induction chemotherapy regimen for patients with high-risk multiple myeloma.
abstract: We evaluated toxicities and responses to a novel, dose intensive and time sequenced, chemotherapy programme (DC-IE) in 45 patients with high-risk myeloma. DC-IE consisted of: dexamethasone (days 1-4); cyclophosphamide (day 5); idarubicin and etoposide (days 8-10). Complete response (CR) was achieved in four patients, six patients achieved near complete responses (nCR) and 21 patients achieved a partial remission (PR). Overall response rate was 76% (CI 56-94%) for newly diagnosed patients (n = 21) and 62% (CI 36-81%) for relapsed/refractory patients (n = 24). Toxicities were limited to myelosuppression; two patients died of sepsis during neutropenia (4%). DC-IE is active and tolerable for high-risk multiple myeloma, including patients with relapsed or refractory disease to anthracycline containing regimens.
authors.affiliation: Divisions of Bone Marrow Transplantation, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA.
authors.forename: O F
authors.initials: OF
authors.lastname: Ballester
authors.forename: L C
authors.initials: LC
authors.lastname: Moscinski
authors.forename: K K
authors.initials: KK
authors.lastname: Fields
authors.forename: J W
authors.initials: JW
authors.lastname: Hiemenz
authors.forename: P E
authors.initials: PE
authors.lastname: Zorsky
authors.forename: S C
authors.initials: SC
authors.lastname: Goldstein
authors.forename: H I
authors.initials: HI
authors.lastname: Saba
authors.forename: A S
authors.initials: AS
authors.lastname: Spiers
authors.forename: L
authors.initials: L
authors.lastname: Kronish
authors.forename: P
authors.initials: P
authors.lastname: Sullivan
authors.forename: G J
authors.initials: GJ
authors.lastname: Elfenbein
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000009:adverse effects; D003907:Dexamethasone / Q000008:administration & dosage / Q000009:adverse effects; D005047:Etoposide / Q000008:administration & dosage / Q000009:adverse effects; D005260:Female; D006801:Humans; D015255:Idarubicin / Q000008:administration & dosage / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000188:drug therapy*; D009503:Neutropenia / Q000139:chemically induced; D015996:Survival Rate; D016896:Treatment Outcome
chemical_list: D005047:Etoposide; D003907:Dexamethasone; D003520:Cyclophosphamide; D015255:Idarubicin