The anti-inflammatory effects of ketoprofen in animal experiments.
The authors investigated the anti-inflammatory actions of ketoprofen using a battery of tests: in the rat paw oedema test induced by five different inciters, in the capillary permeability test, and in measuring the interleukin-8 (IL-8) production and superoxide dismutase (SOD) activity. The findings in these studies show that ketoprofen inhibits rat paw oedema, suppresses capillary permeability, reduces IL-8 production and increases SOD activity in the acetic-acid-induced inflammatory state. These results would seem to provide a clear rationale for exploring the usefulness of ketoprofen in the treatment of acute and chronic inflammatory diseases.
Wang
L M
LM
Department of Preventive Medicine, Tokyo Medical and Dental University, Japan.
Toyoshima
A
A
Mineshita
S
S
Wang
X X
XX
Yamamoto
T
T
Nomura
Y
Y
Yang
L
L
Koikei
Y
Y
Shiba
K
K
Honda
Y
Y
D019342:Acetic Acid / Q000008:administration & dosage / Q000633:toxicity; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D001557:Benzenesulfonates / Q000737:chemistry; D001920:Bradykinin / Q000008:administration & dosage / Q000633:toxicity; D002199:Capillary Permeability / Q000187:drug effects; D002351:Carrageenan / Q000008:administration & dosage / Q000633:toxicity; D004396:Coloring Agents / Q000737:chemistry; D004195:Disease Models, Animal; D004427:Ear Diseases / Q000188:drug therapy; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D004797:Enzyme-Linked Immunosorbent Assay; D006614:Hindlimb; D007249:Inflammation / Q000188:drug therapy*; D007274:Injections, Intraperitoneal; D007275:Injections, Intravenous; D016209:Interleukin-8 / Q000096:biosynthesis; D007660:Ketoprofen / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000378:metabolism; D014992:Xylenes / Q000008:administration & dosage / Q000633:toxicity
D000894:Anti-Inflammatory Agents, Non-Steroidal; D001557:Benzenesulfonates; D004396:Coloring Agents; D016209:Interleukin-8; D014992:Xylenes; D002351:Carrageenan; D007660:Ketoprofen; D013482:Superoxide Dismutase; C006796:brilliant blue; D019342:Acetic Acid; D001920:Bradykinin