[Occlusion of the central retinal vein after vaccination against viral hepatitis B with recombinant vaccines. 4 cases].
OBJECTIVE
Hepatitis B vaccination has been proven to be effective and well-tolerated. Certain neurological, ocular or systemic complications have, however, been reported to be induced by the vaccine. Clinicians should be aware of exceptional ocular complications.


METHODS
Four patients under 50 years of age developed occlusion of the central vein of the retina after vaccination with recombinant hepatitis B vaccine. None of the classical causes of occlusion of the central vein of the retina could be evidenced.


CONCLUSIONS
Several pathophysiological hypotheses have been proposed to explain these ocular manifestations after vaccination: role of immunocomplexes, antigenic cross-reactions, role of immediate hypersensitivity, simulation of a pathogenic lymphocyte repertoire. None of these hypotheses is entirely satisfactory. It is important however to emphasize the need for a complete general evaluation, including an ophthalmological examination in the presence of unexplained ocular manifestations following hepatitis B vaccination.
Granel
B
B
Service de Médecine, CHU de la Timone, Marseille.
Disdier
P
P
Devin
F
F
Swiader
L
L
Riss
J M
JM
Coupier
L
L
Harlé
J R
JR
Jouglard
J
J
Weiller
P J
PJ
D000328:Adult; D005260:Female; D017325:Hepatitis B Vaccines / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012170:Retinal Vein Occlusion / Q000139:chemically induced* / Q000276:immunology / Q000503:physiopathology; D013997:Time Factors; D014614:Vaccines, Synthetic / Q000009:adverse effects*
D017325:Hepatitis B Vaccines; D014614:Vaccines, Synthetic
Occlusion de la veine centrale de la rétine après vaccination contre l'hépatite virale B par vaccin recombinant. Quatre observations.