title: Effect of restraint stress on feeding behavior of rats.
abstract: The expression of appetite reflects the complex functioning of a psychobiological system organized in different levels closely related to each other, in which emotional changes can influence feeding behavior. Benzodiazepines are widely used as anxiolytics and can change behaviors caused by stress. The aim of the present study was to verify the feeding behavior of rats, submitted or not to fasting, after acute and chronic restraint stress. We also evaluated the response to the ingestion of sweet food of chronically restrained animals after the administration of diazepam. Male adult Wistar rats were exposed to restraint 1 h/day for 50 days in the chronic model. In the acute model, there was a single exposure. Four hours after the stress, the animals were placed in a lightened area in the presence of 10 pellets of sweet food (Froot Loops). The number of ingested Froot Loops was measured during a period of 3 min in the presence or absence of fasting. The groups acutely stressed showed ingestion similar to that of the control group, whether they had been fasted or not. The chronically stressed animals showed increased ingestion of sweet food. Diazepam given 60 min before the test session of the stressed rats reduced the ingestion of these animals to control levels. Thus, the chronic stress increases appetite for sweet food, independently of hunger, and diazepam is able to reverse this behavior.
authors.affiliation: Department of Pharmacology, Instituto de Biociências, UFRGS, (Centro), Porto Alegre, RS, Brazil.
authors.forename: D R
authors.initials: DR
authors.lastname: Ely
authors.forename: V
authors.initials: V
authors.lastname: Dapper
authors.forename: J
authors.initials: J
authors.lastname: Marasca
authors.forename: J B
authors.initials: JB
authors.lastname: Corrêa
authors.forename: G D
authors.initials: GD
authors.lastname: Gamaro
authors.forename: M H
authors.initials: MH
authors.lastname: Xavier
authors.forename: M B
authors.initials: MB
authors.lastname: Michalowski
authors.forename: D
authors.initials: D
authors.lastname: Catelli
authors.forename: R
authors.initials: R
authors.lastname: Rosat
authors.forename: M B
authors.initials: MB
authors.lastname: Ferreira
authors.forename: C
authors.initials: C
authors.lastname: Dalmaz
mesh_terms: D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology; D001066:Appetite / Q000187:drug effects / Q000502:physiology; D001835:Body Weight; D003975:Diazepam / Q000494:pharmacology; D005215:Fasting; D005247:Feeding Behavior / Q000187:drug effects / Q000502:physiology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012149:Restraint, Physical; D013312:Stress, Physiological / Q000503:physiopathology*; D013549:Sweetening Agents / Q000494:pharmacology; D013997:Time Factors
chemical_list: D014151:Anti-Anxiety Agents; D013549:Sweetening Agents; D003975:Diazepam