title: [Thymus in systemic lupus erythematosus].
abstract: The role of the thymus in pathogenesis of systemic lupus erythematosus confirms that SLE is a severe autoimmune disease with T-suppressor insufficiency. The latter may be caused by both congenital factors (incompetence of thymic epithelial cells or interleucin-2 defect) and acquired in the course of the disease as a result of inactivation of the thymic hormones or thymic epithelial cells by circulating inhibitors. Measurements of serum thymic factor and evaluation of cellular immunity discovered thymus-dependent failure of antiinfection defense in SLE patients. Tactivin treatment produced a 3-fold increase in thymic activity.
authors.affiliation: Department of Pediatric Diseases, MMA of IM Sechenov.
authors.forename: V I
authors.initials: VI
authors.lastname: Kartashova
authors.forename: O V
authors.initials: OV
authors.lastname: Zairat'iants
authors.forename: L R
authors.initials: LR
authors.lastname: Tarasova
mesh_terms: D000818:Animals; D001323:Autoantibodies / Q000096:biosynthesis; D006801:Humans; D007111:Immunity, Cellular; D008180:Lupus Erythematosus, Systemic / Q000276:immunology* / Q000378:metabolism; D013950:Thymus Gland / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D013951:Thymus Hormones / Q000378:metabolism
chemical_list: D001323:Autoantibodies; D013951:Thymus Hormones
vernacular_title: Timus pri sistemnoi krasnoi volchanke.