title: The prediction of total body water and extracellular water from bioelectric impedance in obese children.
abstract: OBJECTIVE
  To assess the reliability of bioelectric impedance analysis (BIA) for predicting total body water (TBW) and extracellular water (ECW) in obese children.
  
  
  METHODS
  Comparison of five prediction models based on: (i) body weight (Wt), (ii) the impedance (Z) index (ZI = height2/Z), (iii) the association of Wt and ZI, (iv) the body surface area (SA) to impedance ratio (SA:Z) and, (v) the body volume (V) to impedance ratio (V:Z).
  
  
  METHODS
  Thirty obese and 25 control children of 11.2 +/- 1.8 y of age.
  
  
  METHODS
  TBW and ECW were assessed by deuterium and bromide dilution; Z was measured at frequencies of 5,50 and 100 kHz.
  
  
  RESULTS
  In controls, Wt explained 11% more variance of TBW than ZI (r2 = 0.977, SEE = 0.9 I, CV = 3.8%) and the association of Wt and ZI improved the prediction of TBW only slightly (r2 = 0.982, SEE = 0.8 I, CV = 3.5%). The SA:Z and V:Z indexes explained 6 and 33% less variance of TBW respectively as compared to Wt alone. In obese subjects, ZI explained 4% more variance of TBW than Wt (r2 = 0.914, SEE = 1.8 I, CV = 6.4%) and the SA:Z ratio was the most accurate predictor of TBW (r2 = 0.959, SEE = 1.2 I, CV = 4.4%). However, the increase in the explained variance of TBW associated to the use of the SA:Z ratio was of only 1% as compared to the association of ZI and Wt. The V:Z ratio explained 9% less of variance of TBW as compared to ZI. In both control and obese subjects, the association of Wt and ZI offered the best prediction of ECW (r2 = 0.807, SEE = 1.564 I and r2 = 0.826, SEE = 1.035 I, respectively). However, the values of CV were much higher in controls than in obese children (17.5% vs 8.4%) owing to their lower ECW and greater variability in ECW%. ZI was the most accurate predictor of TBW on the pooled sample (n = 55; r2 = 0.910, SEE = 1.932 I; CV = 7.4%). However, it was a poor predictor of ECW on the same sample owing to its high CV (n = 55; r2 = 0.866, SEE = 1.806 I, CV = 17.0%).
  
  
  CONCLUSIONS
  The body surface area to impedance ratio is the most accurate predictor of TBW in obese children but the association of ZI and Wt may be of more interest when BIA is used to estimate both TBW and ECW. The impedance index offers a good prediction of TBW but not of ECW in children with different levels of fatness.
authors.affiliation: Dipartimento di Scienze Biomediche, Università degli Studi, Modena, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Bedogni
authors.forename: M R
authors.initials: MR
authors.lastname: Bollea
authors.forename: S
authors.initials: S
authors.lastname: Severi
authors.forename: O
authors.initials: O
authors.lastname: Trunfio
authors.forename: A M
authors.initials: AM
authors.lastname: Manzieri
authors.forename: N
authors.initials: N
authors.lastname: Battistini
mesh_terms: D001823:Body Composition; D001834:Body Water; D001835:Body Weight; D016022:Case-Control Studies; D002648:Child; D017097:Electric Impedance; D005110:Extracellular Space; D005260:Female; D006801:Humans; D008297:Male; D009765:Obesity / Q000503:physiopathology*; D011237:Predictive Value of Tests