title: Physical mapping of the 5 Mb D9S196-D9S180 interval harboring the basal cell nevus syndrome gene and localization of six genes in this region.
abstract: The basal cell nevus syndrome (Gorlin syndrome) is characterized by multiple basal cell carcinomas and diverse developmental defects. The gene responsible for this syndrome has been mapped previously to a 2 cM interval between D9S196 and D9S 180 at 9q22.3, and very recently mutations of a candidate gene in this region--the human homolog of the Drosophila patched gene have been identified. We report here on physical mapping studies integrating a contig of yeast artificial chromosomes and bacterial artificial chromosomes with a long-range map spanning approximately 5 Mb between the recombination-determined flanking markers. Six genes have been mapped to this interval.
authors.affiliation: Department of Dermatology, San Francisco General Hospital, California 94110, USA.
authors.forename: J
authors.initials: J
authors.lastname: Xie
authors.forename: A
authors.initials: A
authors.lastname: Quinn
authors.forename: X
authors.initials: X
authors.lastname: Zhang
authors.forename: J
authors.initials: J
authors.lastname: Bare
authors.forename: A
authors.initials: A
authors.lastname: Rothman
authors.forename: C
authors.initials: C
authors.lastname: Collins
authors.forename: S
authors.initials: S
authors.lastname: Cutone
authors.forename: M
authors.initials: M
authors.lastname: Rutter
authors.forename: M K
authors.initials: MK
authors.lastname: McCormick
authors.forename: E
authors.initials: E
authors.lastname: Epstein
mesh_terms: D015067:17-Hydroxysteroid Dehydrogenases / Q000235:genetics; D000818:Animals; D001478:Basal Cell Nevus Syndrome / Q000235:genetics*; D002874:Chromosome Mapping; D018244:Chromosomes, Artificial, Yeast; D002899:Chromosomes, Human, Pair 9 / Q000235:genetics; D004330:Drosophila / Q000235:genetics; D006597:Fructose-Bisphosphatase / Q000235:genetics; D017344:Genes, Insect; D005819:Genetic Markers; D006801:Humans; D011110:Polymorphism, Genetic; D039381:RNA Cap-Binding Proteins; D016601:RNA-Binding Proteins / Q000235:genetics; D012091:Repetitive Sequences, Nucleic Acid; D012689:Sequence Homology, Nucleic Acid; D016324:Sequence Tagged Sites
chemical_list: D005819:Genetic Markers; D039381:RNA Cap-Binding Proteins; D016601:RNA-Binding Proteins; D015067:17-Hydroxysteroid Dehydrogenases; D006597:Fructose-Bisphosphatase