Effect of stobadine on gastric mucosal injury after ischaemia/reperfusion.
The ability of stobadine to prevent gastric mucosal injury was tested in rat gastric ischaemia induced by 30 min clamping of the coeliac artery with subsequent 30 min reperfusion. Serious injury of gastric mucosa (macroscopic and microscopic) and the increase of microvascular permeability was found after ischaemia/reperfusion in rats without stobadine. After oral pretreatment with stobadine (5 mg.kg-1, 30 min before surgery), the development of gastric mucosal lesions and changes of vascular permeability were significantly decreased.
Mojzis
J
J
Department of Pharmacology, Medical Faculty, Safarik University, Kosice, Slovak Republic.
Pomfy
M
M
Kohút
A
A
Benes
L
L
Nicák
A
A
Mirossay
L
L
D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D002199:Capillary Permeability / Q000187:drug effects / Q000502:physiology; D002243:Carbolines / Q000494:pharmacology*; D005753:Gastric Mucosa / Q000098:blood supply / Q000473:pathology*; D007511:Ischemia / Q000150:complications / Q000473:pathology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012039:Regional Blood Flow / Q000502:physiology; D015427:Reperfusion Injury / Q000150:complications / Q000473:pathology*; D013276:Stomach Ulcer / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*
D000897:Anti-Ulcer Agents; D002243:Carbolines; C100106:dicarbine