[Early postirradiation changes in Na+ and fluid transport across alveolar epithelium in rats].
To study changes in Na+ and fluid transport that occur soon after irradiation of the thorax, we used fluid-filled isolated rat lungs. Irradiation 15 Gy of 60Co doubled the fluid absorption rate across the alveolar epithelium within 2 weeks, but fluid absorption had returned to the baseline values by 3 weeks after irradiation. The timing of this change in fluid absorption was parallel to the time course of Na+ escape across alveolar epithelium and the two correlated closely. These data suggest that a dysfunction of alveolar epithelial Na+ transport is involved in the development of pulmonary edema after irradiation of the thorax.
Suzuki
S
S
Department of Thoracic Surgery, Tohoku University, Sendai.
Noda
M
M
Abe
Y
Y
Sugita
M
M
Ono
S
S
Tanita
T
T
Koike
K
K
Fujimura
S
S
D000818:Animals; D001692:Biological Transport; D001826:Body Fluids / Q000378:metabolism*; D004848:Epithelium / Q000378:metabolism; D066298:In Vitro Techniques; D008297:Male; D011650:Pulmonary Alveoli / Q000378:metabolism*; D017564:Radiation Pneumonitis / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012964:Sodium / Q000378:metabolism*
D012964:Sodium