title: A piezocomposite shock wave generator with electronic focusing capability: application for producing cavitation-induced lesions in rabbit liver.
abstract: In this work, a piezocomposite shock wave generator with electronic focusing capability is presented. The system is composed of a bidimensional array and its electronic hardware. The array is composed of 274 independent piezocomposite transducers arranged in a spherical shell of 280 mm in diameter and focused at 190 mm from its surface. The electronic hardware includes 274 x 6.6 kV distinct impulse generators. For the purpose of performing the electronic steering of shock waves, the delay time of each channel can be adjusted from 100 ns to 100 microseconds in steps of 100 ns. In order to enhance the effect of cavitation at the focus for the purpose of tissue destruction, the pressure-time waveform starts with a half cycle of negative pressure with a peak amplitude of about -150 x 10(5) Pa, followed by a very steep shock front with a positive peak pressure > 1000 x 10(5) Pa and a rise time of about 10 ns. Using this generator, the cavitation-induced lesions in rabbit liver were studied. To obtain a predefined lesion volume, two methods of scanning were used: mechanical and electronic. Comparison of the lesions obtained by these two methods shows that they have identical macroscopic and histological characteristics, which justify the feasibility of electronic beam steering of shock waves in tissue destruction applications.
authors.affiliation: INSERM, Unité 281, Lyon, France. Jahan@Lyon151.Inserm.Fr
authors.forename: J
authors.initials: J
authors.lastname: Tavakkoli
authors.forename: A
authors.initials: A
authors.lastname: Birer
authors.forename: A
authors.initials: A
authors.lastname: Arefiev
authors.forename: F
authors.initials: F
authors.lastname: Prat
authors.forename: J Y
authors.initials: JY
authors.lastname: Chapelon
authors.forename: D
authors.initials: D
authors.lastname: Cathignol
mesh_terms: D000818:Animals; D008096:Lithotripsy / Q000295:instrumentation*; D008099:Liver / Q000000981:diagnostic imaging / Q000473:pathology*; D009336:Necrosis; D011817:Rabbits; D014159:Transducers; D014463:Ultrasonography