Latent herpes simplex virus type 1 gene expression in ganglia innervating the human gastrointestinal tract.
Using in situ hybridization, we demonstrated that latent herpes simplex virus type 1 (HSV-1) gene expression is prevalent in human adult nodose ganglia. This suggests that infection of gastrointestinal sensory nerves, probably through swallowed virus-laden oral secretions, occurs commonly and that HSV-1 reactivating from this site may play a role in recurrent gastrointestinal disorders.
Gesser
R M
RM
Division of Allergy, Immunology and Infectious Diseases, The Children's Hospital of Philadelphia, Pennsylvania 19104, USA. gesser@email.chop.edu
Koo
S C
SC
D000368:Aged; D000369:Aged, 80 and over; D016375:Antisense Elements (Genetics); D005260:Female; D015870:Gene Expression; D018259:Herpesvirus 1, Human / Q000235:genetics* / Q000502:physiology; D006801:Humans; D017403:In Situ Hybridization; D008297:Male; D008875:Middle Aged; D009620:Nodose Ganglion / Q000821:virology*; D012333:RNA, Messenger / Q000032:analysis; D017735:Virus Latency
D016375:Antisense Elements (Genetics); D012333:RNA, Messenger