Behavioral and neurochemical effects of a chronic choline-deficient diet in the rat.
Chronic administration of a choline-deficient diet for 20 days caused no modification in ACh levels in the cortex, hippocampus and olfactory system of the rat and an increase in the density (Bmax) of the muscarinic receptors in the hippocampus. The choline-deficient diet caused no modification in noradrenaline levels and a reduction in the density of alpha1-adrenoceptors in the cortex, hippocampus and olfactory system. This paper discusses the possibility that these neurochemical effects are correlated with the reduction in spontaneous memory decay which was observed in the staircase maze after 20 days of a choline-deficient diet.
Molinengo
L
L
Istituto di Farmacologia e Farmacognosia, Universitá di Torino, Italy.
Orsetti
M
M
Ghi
P
P
D000109:Acetylcholine / Q000378:metabolism; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001923:Brain Chemistry / Q000187:drug effects*; D002796:Choline Deficiency / Q000378:metabolism* / Q000523:psychology*; D004032:Diet; D007700:Kinetics; D008297:Male; D018782:Maze Learning / Q000187:drug effects / Q000502:physiology; D008568:Memory / Q000502:physiology; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D018340:Receptors, Adrenergic, alpha-1 / Q000187:drug effects / Q000378:metabolism; D011976:Receptors, Muscarinic / Q000187:drug effects / Q000378:metabolism
D018340:Receptors, Adrenergic, alpha-1; D011976:Receptors, Muscarinic; D000109:Acetylcholine; D009638:Norepinephrine