title: D1 dopamine receptor mediation of social and nonsocial emotional reactivity in mice: effects of housing and strain difference in motor activity.
abstract: The study examined the effects of isolation housing and the role of D1 dopamine receptors on isolation-induced social and nonsocial (acoustic startle) reactivity in mice high (C57BL/6) and low (A) in motor activity. Isolation housing had no effect on acoustic startle but increased strain-specific forms of social reactivity. The D1 agonist dihydrexidine (DHX) increased acoustic startle in isolated mice of both strains, but this effect was more pronounced in C57BL/6 mice. In this strain, DHX and the D1 agonist SKF-81297 increased locomotor forms of social reactivity (e.g., escape, jump), whereas the D1 antagonist SCH-23390 increased stationary reactivity (e.g., freezing). In A mice, DHX and SKF-81297 increased and decreased stationary reactivity, respectively, whereas SCH-23390 had no effect on these behaviors. Administration of SKF-81297 after pretreatment with SCH-23390 or the D2 antagonist sulpiride confirmed the importance of D1 receptors in mediating specific forms of social reactivity in C57BL/6 mice. These results suggest an important relationship between social reactivity and motor activity and an important, albeit strain-dependent, role for D1 receptors in mediating specific emotional behaviors.
authors.affiliation: Department of Psychology, University of North Carolina at Chapel Hill, USA.
authors.forename: P L
authors.initials: PL
authors.lastname: Gendreau
authors.forename: J L
authors.initials: JL
authors.lastname: Gariépy
authors.forename: J M
authors.initials: JM
authors.lastname: Petitto
authors.forename: M H
authors.initials: MH
authors.lastname: Lewis
mesh_terms: D000818:Animals; D001143:Arousal / Q000187:drug effects / Q000502:physiology*; D001552:Benzazepines / Q000494:pharmacology; D018491:Dopamine Agonists / Q000494:pharmacology; D004644:Emotions / Q000187:drug effects / Q000502:physiology*; D005260:Female; D008297:Male; D051379:Mice; D008805:Mice, Inbred A; D008810:Mice, Inbred C57BL; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology*; D010617:Phenanthridines / Q000494:pharmacology; D017447:Receptors, Dopamine D1 / Q000187:drug effects / Q000502:physiology*; D013216:Reflex, Startle / Q000187:drug effects / Q000502:physiology; D012919:Social Behavior; D012934:Social Isolation; D013045:Species Specificity; D013469:Sulpiride / Q000494:pharmacology
chemical_list: D001552:Benzazepines; D018491:Dopamine Agonists; D010617:Phenanthridines; D017447:Receptors, Dopamine D1; C061532:dihydrexidine; C067113:SK&F 81297; D013469:Sulpiride