The effects of triethanolamine myristate, a fatty acid salt, on the availability of riboflavin in humans.
A human study examined the effect of administering a triethanolamine myristate tablet 30 min prior to or concomitantly with a fast release riboflavin tablet and a slow release riboflavin tablet. There was no significant difference between any of the treatments although treatments with the slow release riboflavin resulted in greater urinary excretion of riboflavin. It is possible that a difference may only be seen within subjects because gastric emptying has a large intraindividual variation. When triethanolamine myristate is administered to delay gastric emptying, the inhibition may be affected by the individual's normal transit rate. Another reason-might be lack of sufficient bile salts in the fasting state, reducing chyme and micelle formation, or a higher dose of triethanolamine myristate may have been needed to detect a difference.
Forusz
H
H
University of Cincinnati, USA.
Ritschel
W A
WA
D000328:Adult; D016503:Drug Delivery Systems; D004347:Drug Interactions; D004983:Ethanolamines / Q000008:administration & dosage / Q000494:pharmacology*; D005746:Gastric Emptying / Q000187:drug effects*; D006801:Humans; D008297:Male; D019814:Myristic Acid; D009227:Myristic Acids / Q000493:pharmacokinetics*; D012256:Riboflavin / Q000008:administration & dosage / Q000493:pharmacokinetics*
D004983:Ethanolamines; D009227:Myristic Acids; D019814:Myristic Acid; C009546:triethanolamine; D012256:Riboflavin