Ovarian response to purified FSH in infertile women with long-standing hypogonadotrophic hypogonadism.
It has previously been proposed that all anovulatory women requiring exogenous gonadotrophin therapy could be treated by purified FSH alone in the follicular phase. We have studied the ovarian response to purified FSH in 5 amenorrhoeic women with low endogenous LH production as a result of long-standing hypothalamic amenorrhoea. Follicles developed in all of the women but the rise in oestradiol was very slow. As a consequence of the HCG injection being delayed to allow the follicles to become functionally mature, too many follicles attained a preovulatory size. After the treatment was changed to more conventional preparations containing both FSH and LH, the women had improved ovarian responses and 3 of them conceived. It is clear that FSH alone will promote follicular growth but that LH is needed to stimulate follicular function. We conclude that LH does play an important role in follicular maturation and that it is a critical component of exogenous gonadotrophin therapy for women with prolonged hypogonadotrophic hypogonadism.
Fox
R
R
University of Bristol, Department of Obstetrics and Gynaecology, St Michael's Hospital, United Kingdom.
Ekeroma
A
A
Wardle
P
P
D000328:Adult; D000568:Amenorrhea / Q000188:drug therapy / Q000503:physiopathology; D005260:Female; D005640:Follicle Stimulating Hormone / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D007006:Hypogonadism / Q000188:drug therapy / Q000503:physiopathology*; D007247:Infertility, Female / Q000503:physiopathology*; D006080:Ovarian Follicle / Q000187:drug effects / Q000502:physiology; D010053:Ovary / Q000187:drug effects* / Q000503:physiopathology*
D005640:Follicle Stimulating Hormone