[Somatostatin receptors. A new way to diagnosis and therapy of neuroendocrine tumors].
Verification of the presence of somatostatin receptors on neuroendocrine tumour cells opened up unique diagnostic and therapeutic possibilities. Long-acting somatostatin analogues are currently used to alleviate symptoms of excessive hormone synthesis in patients with such tumours. Radiolabelled somatostatin analogues can be used both for high specificity and high sensitivity scintigraphic localisation of such tumours and for intraoperative scintillation detection. Detailed studies in patients and in tumour cells in vitro have shown 111In-octreotide uptake to be high and retention times long in tumour tissue, and have yielded evidence of intracellular localisation of the radionuclide. These findings thus showed somatostatin receptor-mediated radiotherapy to be a possible treatment alternative after close characterisation of the individual tumour. In the future, it may be possible to use other peptide receptors (e g, growth factor receptors) according to the same principles as applied in the case of somatostatin receptors.
Wängberg
B
B
Avdelningen för kirurgi, Sahlgrenska sjukhuset, Göteborg.
Nilsson
O
O
Wigander
A
A
Johansson
V
V
Forssell-Aronsson
E
E
Andersson
P
P
Fjälling
M
M
Tisell
L E
LE
Ahlman
H
H
D001345:Autoradiography; D003131:Combined Modality Therapy; D006801:Humans; D018358:Neuroendocrine Tumors / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000628:therapy; D011877:Radionuclide Imaging; D017481:Receptors, Somatostatin / Q000235:genetics / Q000378:metabolism
D017481:Receptors, Somatostatin
Somatostatinreceptorer. Ny väg till diagnos och terapi av neuroendokrina tumörer.