Lichenoid changes in mycosis fungoides.
BACKGROUND
The lichenoid tissue reaction (LTR) is present in a variety of dermatoses. Numerous histologic variants of mycosis fungoides (MF) have also been described.


OBJECTIVE
Our purpose was to analyze a subset of patients with mycosis fungoides (MF) who had a prominent LTR at the time of presentation.


METHODS
Clinical and pathologic features were evaluated in 12 patients with MF and an LTR.


RESULTS
The primary complaint was intense pruritus (in 10 of 12 patients). An accelerated course was noted in one half of the patients including four with Sézary syndrome. Four patients died: two with Sézary syndrome and two with extensive patch/plaque MF. Lymphocyte atypia, prominent basal cell layer epidermotropism, and the presence of plasma cells and eosinophils may help to distinguish lichenoid MF from lichen planus.


CONCLUSIONS
A subset of patients with MF present with lichenoid changes. The pathologic features may have a striking resemblance to lichen planus. Our findings suggest that lichenoid changes in MF tend to be associated with intense pruritus and may connote a poor prognosis.
Guitart
J
J
Department of Dermatology, Northwestern University Medical Center, Chicago, IL 60611, USA.
Peduto
M
M
Caro
W A
WA
Roenigk
H H
HH
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D017512:Lichenoid Eruptions / Q000150:complications*; D008297:Male; D008875:Middle Aged; D009182:Mycosis Fungoides / Q000150:complications / Q000276:immunology / Q000473:pathology*; D012751:Sezary Syndrome / Q000150:complications / Q000473:pathology; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000150:complications / Q000276:immunology / Q000473:pathology*