title: Long-term effects of neonatal sodium restriction on blood pressure.
abstract: In 1980, a randomized trial was conducted among 476 Dutch newborn infants to study the effect of a low or normal sodium diet on blood pressure during the first 6 months of life. At the end of the trial, systolic blood pressure in the low sodium group (n = 231) was 2.1 mm Hg lower than in the control group (n = 245). To investigate whether contrasting levels of sodium intake in infancy are associated with blood pressure differences in adolescence, we measured blood pressure in 167 children from the original cohort (35%) after 15 years of follow-up. We assessed the differences in systolic and diastolic blood pressure levels between the diet groups using a multivariate regression model with adjustment for potential confounders. The adjusted systolic blood pressure at follow-up was 3.6 mm Hg lower (95% confidence interval, -6.6 to -0.5) and the diastolic pressure was 2.2 mm Hg lower (95% confidence interval, -4.5 to 0.2) in children who had been assigned to the low sodium group (n = 71) compared with the control group (n = 96). These findings suggest that sodium intake in infancy may be important in relation to blood pressure later in life.
authors.affiliation: Department of Epidemiology and Biostatistics, Erasmus University Medical School, Rotterdam, The Netherlands. geleijnse@epib.fgg.eur.nl
authors.forename: J M
authors.initials: JM
authors.lastname: Geleijnse
authors.forename: A
authors.initials: A
authors.lastname: Hofman
authors.forename: J C
authors.initials: JC
authors.lastname: Witteman
authors.forename: A A
authors.initials: AA
authors.lastname: Hazebroek
authors.forename: H A
authors.initials: HA
authors.lastname: Valkenburg
authors.forename: D E
authors.initials: DE
authors.lastname: Grobbee
mesh_terms: D000293:Adolescent; D000367:Age Factors; D001794:Blood Pressure; D003971:Diastole; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007227:Infant Nutritional Physiological Phenomena; D007231:Infant, Newborn; D008297:Male; D015999:Multivariate Analysis; D009426:Netherlands; D012044:Regression Analysis; D012737:Sex Factors; D012982:Sodium, Dietary; D013599:Systole; D013997:Time Factors
chemical_list: D012982:Sodium, Dietary