Excitatory and trophic action of GABA and related substances in newborn mice and organotypic cerebellar culture.
Muscimol and diazepam produced an excitatory effect on the behavior of newborn mice instead of depression as in mature animals. In organotypic culture of mouse cerebellum, muscimol increased intracellular Ca2+ concentration and chronic application of bicuculline reduced number of Purkinje cells.
Obata
K
K
Laboratory of Neurochemistry, National Institute of Physiological Sciences, Okazaki, Japan.
D000375:Aging / Q000502:physiology; D000818:Animals; D000831:Animals, Newborn / Q000254:growth & development / Q000502:physiology*; D001640:Bicuculline / Q000494:pharmacology; D002118:Calcium / Q000378:metabolism; D002452:Cell Count / Q000187:drug effects; D002531:Cerebellum / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D003975:Diazepam / Q000494:pharmacology; D018682:GABA Agents / Q000494:pharmacology*; D018755:GABA Agonists / Q000494:pharmacology; D018756:GABA Antagonists / Q000494:pharmacology; D018757:GABA Modulators / Q000494:pharmacology; D007425:Intracellular Membranes / Q000378:metabolism; D051379:Mice; D008813:Mice, Inbred ICR; D009043:Motor Activity / Q000187:drug effects*; D009118:Muscimol / Q000494:pharmacology; D009924:Organ Culture Techniques; D011689:Purkinje Cells / Q000166:cytology / Q000502:physiology; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology*
D018682:GABA Agents; D018755:GABA Agonists; D018756:GABA Antagonists; D018757:GABA Modulators; D009118:Muscimol; D005680:gamma-Aminobutyric Acid; D003975:Diazepam; D002118:Calcium; D001640:Bicuculline