Effect of progressive incremental exercise and beta-adrenergic blockade on erythrocyte ion concentrations.
Ion concentrations in whole blood, plasma, and erythrocytes from arterialized venous blood were examined in eight healthy males performing incremental exercise tests to fatigue on an electrically braked cycle ergometer. Exercise was performed during control and low dose (LD) and high dose (HD) of propranolol (beta-blockade). The LD and HD resulted in a significant decrease in peak heart rate compared with control, while peak oxygen uptake during HD was significantly less than either control or LD. Plasma potassium concentration ([K+]) increased significantly during exercise for control, LD, and HD, while LD and HD plasma [K+] were both significantly greater than control. Erythrocyte [K+] increased significantly for control to 119.2 +/- 1.3 mmol/L, for LD to 116.9 +/- 2.0 mmol/L, and for HD to 117.7 +/- 1.2 mmol/L. Plasma lactate concentration ([Lac-]) increased significantly during exercise for control, LD, and HD. Erythrocyte [Lac-] increased significantly for control to 6.4 +/- 0.8 mmol/L, for LD to 6.4 +/- 0.6 mmol/L, and for HD to 5.0 +/- 0.5 mmol/L, with HD [Lac-] less than either control or LD. beta-Blockade did not significantly alter the percent change in mean corpuscular volume (% delta MCV) during exercise. The results indicate that incremental exercise produces an increase in erythrocyte [Lac-] and [K+]. Although beta-blockade increased plasma [K+] at peak exercise, there was no alteration in erythrocyte [K+] response. The treatment did not impair the ability of the erythrocyte to maintain MCV.
McKelvie
R S
RS
Preventive Cardiology and Therapeutics Program, Hamilton Civic Hospitals, Ambrose Cardiorespiratory Unit, McMaster Health Sciences Centre, ON, Canada.
Jones
N L
NL
Heigenhauser
G J
GJ
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000328:Adult; D002712:Chlorides / Q000097:blood*; D004305:Dose-Response Relationship, Drug; D004912:Erythrocytes / Q000187:drug effects* / Q000378:metabolism*; D015444:Exercise / Q000502:physiology*; D006400:Hematocrit; D006454:Hemoglobins / Q000187:drug effects; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007477:Ions; D019344:Lactic Acid / Q000097:blood*; D008297:Male; D011188:Potassium / Q000097:blood*; D011433:Propranolol / Q000494:pharmacology*; D012964:Sodium / Q000097:blood*
D000319:Adrenergic beta-Antagonists; D002712:Chlorides; D006454:Hemoglobins; D007477:Ions; D019344:Lactic Acid; D012964:Sodium; D011433:Propranolol; D011188:Potassium