Genetic heterogeneity of familial atrial myxoma syndromes (Carney complex).
Familial atrial myxomas may present as a component of the Carney complex, an autosomal dominant multiple neoplasia and lentiginosis syndrome. Although a gene defect for the Carney complex in some families maps to chromosome 2p, this syndrome is genetically heterogeneous, and other genetic loci also produce familial atrial myxomas.
Basson
C T
CT
Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.
MacRae
C A
CA
Korf
B
B
Merliss
A
A
D000328:Adult; D002648:Child; D002889:Chromosomes, Human, Pair 2; D005260:Female; D018740:Genetic Heterogeneity; D006325:Heart Atria; D006338:Heart Neoplasms / Q000235:genetics*; D006801:Humans; D008126:Lod Score; D008297:Male; D008875:Middle Aged; D009232:Myxoma / Q000235:genetics*; D009386:Neoplastic Syndromes, Hereditary / Q000235:genetics*; D010375:Pedigree; D012307:Risk Factors