[An experimental study of the effect of immunomodulators on the immune response to the anatoxin components of adsorbed DPT vaccine against a background of poisoning].
An experiment of rabbits subjected to artificial lead intoxication revealed that after the immunization of the animals with adsorbed DPT vaccine myelopid and thymoptin exhibited practically the same immunomodulating activity with respect to antibody response to diphtheria and tetanus toxoids, exceeding that of rabbits without intoxication. Still the immunomodulators used in this experiment did not completely compensate the negative effect of intoxication on antibody response to the toxoids. For the first time after immunization with adsorbed DPT toxoid lymphocytes capable of binding diphtheria toxoid were detected and the specific features of their dynamics in comparison with the activity of antitoxin were established. Myelopid and thymoptin were found to modulate immune response, evaluated by the content of antigen-binding lymphocytes, the injection of thymoptin completely compensating the negative effect of intoxication.
Karal'nik
B V
BV
Markova
S G
SG
Savchenko
E Ia
EIa
D028341:Activins; D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000327:Adsorption; D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood; D001853:Bone Marrow; D003017:Clostridium tetani / Q000276:immunology; D003353:Corynebacterium diphtheriae / Q000276:immunology; D004168:Diphtheria Toxoid / Q000276:immunology*; D015721:Diphtheria-Tetanus-Pertussis Vaccine / Q000276:immunology*; D007855:Lead Poisoning / Q000276:immunology*; D009842:Oligopeptides; D010455:Peptides / Q000494:pharmacology*; D011817:Rabbits; D013745:Tetanus Toxoid / Q000276:immunology*; D013947:Thymosin / Q000031:analogs & derivatives* / Q000494:pharmacology; D013949:Thymus Extracts / Q000494:pharmacology*; D013997:Time Factors
D000276:Adjuvants, Immunologic; D000907:Antibodies, Bacterial; D004168:Diphtheria Toxoid; D015721:Diphtheria-Tetanus-Pertussis Vaccine; D009842:Oligopeptides; D010455:Peptides; D013745:Tetanus Toxoid; D013949:Thymus Extracts; C044147:activin B; D028341:Activins; C065652:timoptin; C048617:myelopeptides; D013947:Thymosin
Izuchenie v éksperimente vliianiia immunomoduliatorov na immunnyĭ otvet k anaktosinnym komponentam AKDS na fone intoksikatsii.