Expression of serine/threonine kinase receptors in traumatic brain injury.
The aim of this study was to investigate the expression of serine/threonine kinase receptors in the brain following traumatic brain injury. We report here that, the recently cloned and characterized bone morphogenetic protein (BMP) receptor type II (BMPR-II) and the activin receptor type IA (ActR-1) Act: mRNAs were simultaneously up-regulated in neurones in the dentate gyrus 6 h after a mild cerebral contusion injury. This findings was specific for these receptors since other investigated genes (i.e. ActR-II, ActR-IB, trkB and c-fos) showed other temporal patterns. These data suggest that type I and type II receptors act together in signal transduction in vivo and that BMPs may be involved in neuronal plasticity after traumatic brain injury.
Lewén
A
A
Department of Neurosurgery, Uppsala University Hospital and Biomedical Centre, Sweden.
Söderström
S
S
Hillered
L
L
Ebendal
T
T
D000818:Animals; D052006:Bone Morphogenetic Protein Receptors, Type II; D001930:Brain Injuries / Q000378:metabolism*; D017403:In Situ Hybridization; D008297:Male; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D017459:Receptors, Amino Acid / Q000378:metabolism*; D014542:Uridine Monophosphate / Q000031:analogs & derivatives* / Q000378:metabolism
D017459:Receptors, Amino Acid; C028372:1-(5'-phospho-beta-D-ribofuranosyl)barbituric acid; D014542:Uridine Monophosphate; D017346:Protein Serine-Threonine Kinases; C498220:Bmpr2 protein, rat; D052006:Bone Morphogenetic Protein Receptors, Type II