Activation of the prefrontal, occipital and parietal cortices during go/no-go discrimination tasks in the monkey as revealed by positron emission tomography.
The regions of the monkey brain involved in cognito-behavioral tasks were mapped using the H2(15)O positron emission tomography (PET) activation technique. Monkeys performed hand movements in an asymmetrically rewarded go/no-go reaction-time task with discrimination between green (go) and red (no-go) light signals. Regional cerebral blood flow (rCBF) was measured during the go/no-go task and a control task in which only go signals were presented. In the go/no-go task, when compared with the control, a significant increase in rCBF was noted in the following regions: (1) the principal sulci; (2) the anterodorsal frontal pole; (3) the anterior part of the inferior occipital sulcus which appeared to be the V4; and (4) the parieto-occipital region. The increase in the principal sulci may be related to the no-go decision and motor suppression in the area, as interpreted in our previous electrophysiological studies. The present results appear to support electrophysiological observations on visual perception and motor suppression and reflect a mode of their functional integration.
Tsujimoto
T
T
Department of Integrative Brain Science, Graduate School of Medicine, Kyoto University, Japan. j51387@sakura.kudpc.kyoto-u.ac.jp
Ogawa
M
M
Nishikawa
S
S
Tsukada
H
H
Kakiuchi
T
T
Sasaki
K
K
D000818:Animals; D002540:Cerebral Cortex / Q000098:blood supply / Q000502:physiology*; D002560:Cerebrovascular Circulation / Q000502:physiology; D003118:Color Perception / Q000502:physiology; D004193:Discrimination Learning / Q000502:physiology*; D005260:Female; D008251:Macaca; D009778:Occipital Lobe / Q000098:blood supply / Q000502:physiology; D010296:Parietal Lobe / Q000098:blood supply / Q000502:physiology; D010775:Photic Stimulation; D017397:Prefrontal Cortex / Q000098:blood supply / Q000502:physiology; D014055:Tomography, Emission-Computed