title: Plasma alpha 1-acid glycoprotein in chickens infected with infectious bursal disease virus.
abstract: The concentration and affinity to concanavalin A (ConA) of plasma alpha 1-acid glycoprotein (AGP) and AGP levels in extracts of liver tissues were investigated in specific-pathogen-free chickens infected with the highly virulent HPS-2 strain or virulent reference GBF-1 strain of infectious bursal disease virus. The plasma AGP value in uninfected control 3- to 7-wk-old chickens was 161.8 +/- 25.8 micrograms/ml (mean +/- SD), and ConA-unreactive and ConA-reactive AGP comprised 47% and 63% of total AGP. Increases in AGP levels in plasma and liver extracts were observed in both the HPS-2 and the GBF-1 groups, although albumin levels decreased. The plasma AGP values were higher in the HPS-2 group than in the GBF-1 group through the experimental period. In the HPS-2 group, ConA-reactive AGP reached levels 6.8-fold greater than control values and comprised 80% of total AGP at 4 days post-inoculation. In the lipopolysaccharide group, a great increase in ConA-reactive AGP was observed.
authors.affiliation: Department of Veterinary Pathology, Faculty of Agriculture, Yamaguchi University, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Inoue
authors.forename: W
authors.initials: W
authors.lastname: Satoh
authors.forename: H
authors.initials: H
authors.lastname: Murakami
mesh_terms: D000818:Animals; D018175:Birnaviridae Infections / Q000097:blood* / Q000473:pathology; D002645:Chickens; D003208:Concanavalin A; D007243:Infectious bursal disease virus / Q000302:isolation & purification / Q000472:pathogenicity; D008099:Liver / Q000473:pathology*; D009961:Orosomucoid / Q000032:analysis*; D012016:Reference Values; D012709:Serum Albumin / Q000032:analysis; D013997:Time Factors; D014774:Virulence
chemical_list: D009961:Orosomucoid; D012709:Serum Albumin; D003208:Concanavalin A