Erythrophagocytosis and its relation to band 3 clustering in chronic myelogenous leukemia.
Band 3, a major erythrocyte membrane glycoprotein, undergoes topographic redistribution leading to enhanced clustering, in chronic myelogenous leukemia (CML). This is probably due to the binding of heme compounds to the CML erythrocyte membrane resulting from depletion of cellular levels of reduced glutathione (GSH). Band 3 clustering appears to be one of the factors associated with increased erythrophagocytosis in CML.
Das
A K
AK
Department of Chemistry, Bose Institute, Calcutta, India.
Sinha
A K
AK
Basu
J
J
D001457:Anion Exchange Protein 1, Erythrocyte / Q000378:metabolism*; D004912:Erythrocytes / Q000378:metabolism*; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000097:blood / Q000378:metabolism*; D015227:Lipid Peroxidation; D008264:Macrophages / Q000502:physiology; D010587:Phagocytosis
D001457:Anion Exchange Protein 1, Erythrocyte