The effect of furazolidone and furaltadone on drug metabolism in rats.
This work examines the effect of oral treatment of rats with the nitrofuran drugs furazolidone (FZ) and furaltadone (F) at doses of 100, 200 and 400 mg/kg for 4 days, or F in the drinking water at concentrations of 0.1, 0.2 and 0.4% w/v for 14 days, on drug metabolism in vivo. FZ at doses of 200 and 400 mg/kg, and F at a dose of 400 mg/kg or at a concentration of 0.4% w/v in water depressed growth and prolonged pentobarbitone-induced sleeping time. Treatment also significantly increased the blood concentration of metronidazole when measured 30 and 40 min after metronidazole administration. Administration of tremorine (25 mg/kg, i.p.) to control vehicle-treated rats produced within 2-3 min tremors, piloerection, profuse salivation, defecation urination and chromodacryorrhesis (red tears). The onset of appearance of these signs was delayed to 7-12 min in rats pretreated with FZ or F (100 mg/kg, 4 days) or cimetidine (50 mg/kg, i.p.) given 45 min earlier. Taken together, these results suggest that FZ and F inhibit drug metabolism in rats. Treatment with these nitrofuran drugs may alter the disposition of certain drugs which may be given concomitantly with them.
Ali
B H
BH
Desert and Marine Environment Research Centre, Faculty of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates.
Tanira
M O
MO
Bashir
A K
AK
D000818:Animals; D000892:Anti-Infective Agents, Urinary / Q000494:pharmacology*; D001835:Body Weight / Q000187:drug effects; D004347:Drug Interactions; D005664:Furazolidone / Q000494:pharmacology*; D008297:Male; D008795:Metronidazole / Q000008:administration & dosage / Q000097:blood; D009581:Nitrofurans / Q000494:pharmacology*; D009929:Organ Size / Q000187:drug effects; D023303:Oxazolidinones; D010424:Pentobarbital / Q000008:administration & dosage / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012890:Sleep; D013737:Testis / Q000187:drug effects; D013997:Time Factors; D014202:Tremor / Q000139:chemically induced; D014203:Tremorine / Q000008:administration & dosage
D000892:Anti-Infective Agents, Urinary; D009581:Nitrofurans; D023303:Oxazolidinones; D008795:Metronidazole; D005664:Furazolidone; C007795:furaltadon; D010424:Pentobarbital; D014203:Tremorine