A murine model of adenomyosis: the effects of hyperprolactinemia induced by fluoxetine hydrochloride, a selective serotonin reuptake inhibitor, on adenomyosis induction in Wistar albino rats.
OBJECTIVE
The aim of this study was to investigate whether fluoxetine given to castrated and noncastrated rats caused hyperprolactinemia and its effects with respect to adenomyosis.


METHODS
Fluoxetine, a serotonin reuptake inhibitor, was given to Wistar Albino rats for 98 days to produce hyperprolactinemia. The drug was given to two groups consisting of castrated and noncastrated rats and compared to two groups of castrated and noncastrated controls. Prolactin levels were measured and the uteri of the rats were removed for histopathological analysis at the end of 98 days.


METHODS
Marmara University School of Medicine, Department of Histology and Embryology, Zeynep Kamil Women and Children's Hospital.


METHODS
Serum prolactin levels, uterine histopathology.


RESULTS
The prolactin levels of castrated and noncastrated groups treated with fluoxetine were statistically significantly higher when compared to their respective control groups. Histological studies revealed 11 cases of adenomyosis, all within the noncastrated group receiving fluoxetine.


CONCLUSIONS
It was suggested that high serum prolactin levels cause degeneration of myometrial cells in the presence of ovarian steroids that results in a myometrial invasion by endometrial stroma. This invasion eventually progresses to adenomyosis.
Fiçicioğlu
C
C
Department of Obstetrics and Gynecology, Zeynep Kamil Women and Children's Hospital, Istanbul, Turkey.
Tekin
H I
HI
Arioğlu
P F
PF
Okar
I
I
D000818:Animals; D018687:Antidepressive Agents, Second-Generation / Q000633:toxicity*; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D004715:Endometriosis / Q000209:etiology* / Q000473:pathology; D005260:Female; D005473:Fluoxetine / Q000633:toxicity*; D006966:Hyperprolactinemia / Q000139:chemically induced* / Q000473:pathology; D010052:Ovariectomy; D010053:Ovary / Q000502:physiology; D011446:Prospective Studies; D051381:Rats; D017208:Rats, Wistar; D017367:Selective Serotonin Reuptake Inhibitors / Q000633:toxicity*; D014599:Uterus / Q000187:drug effects
D018687:Antidepressive Agents, Second-Generation; D005473:Fluoxetine; D017367:Selective Serotonin Reuptake Inhibitors