title: A reproducible repositioning method for serial magnetic resonance imaging studies of the brain in treatment trials for multiple sclerosis.
abstract: Serial MRI is an important measure of disease progression in evaluating the treatment of multiple sclerosis (MS). Accurate comparisons of scans for lesion activity and lesion volume require precise repositioning of patients. A simple, reproducible repositioning method is described. In a multicenter treatment trial of MS using beta-interferon-1b, this method has been successful, with only 1.1% of scans being rejected because of poor repositioning.
authors.affiliation: NMR Research Group, Institute of Neurology, London, United Kingdom.
authors.forename: H L
authors.initials: HL
authors.lastname: Gallagher
authors.forename: D G
authors.initials: DG
authors.lastname: MacManus
authors.forename: S L
authors.initials: SL
authors.lastname: Webb
authors.forename: D H
authors.initials: DH
authors.lastname: Miller
mesh_terms: D000276:Adjuvants, Immunologic / Q000627:therapeutic use; D001921:Brain / Q000473:pathology*; D018450:Disease Progression; D005069:Evaluation Studies as Topic; D006801:Humans; D016899:Interferon-beta / Q000627:therapeutic use; D008279:Magnetic Resonance Imaging / Q000295:instrumentation / Q000379:methods*; D009103:Multiple Sclerosis / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D000276:Adjuvants, Immunologic; D016899:Interferon-beta