Synchronous primary neuroendocrine carcinoma and adenocarcinoma in Barrett's esophagus.
We report a case of a synchronous primary small-cell carcinoma and adenocarcinoma of the esophagus with ectopic gastrin and calcitonin production. The double primary carcinomas appeared to arise from dysplastic Barrett's mucosa in a 43-year-old woman with a long history of reflux esophagitis. She is one of the few reported long-term survivors treated by surgical resection and combination chemotherapy. The histopathology and treatment of this rare tumor are briefly discussed.
Saw
E C
EC
Department of Surgery, Kaiser Permanente Medical Center, Hayward, California 94545-4297, U.S.A.
Yu
G S
GS
Wagner
G
G
Heng
Y
Y
D000230:Adenocarcinoma / Q000150:complications / Q000473:pathology*; D000328:Adult; D001471:Barrett Esophagus / Q000150:complications* / Q000473:pathology; D018278:Carcinoma, Neuroendocrine / Q000150:complications / Q000473:pathology; D018288:Carcinoma, Small Cell / Q000150:complications / Q000473:pathology*; D004938:Esophageal Neoplasms / Q000150:complications / Q000473:pathology*; D005260:Female; D006801:Humans; D009378:Neoplasms, Multiple Primary / Q000150:complications / Q000473:pathology*