Comparison of in vivo red cell survival of donations collected by Haemonetics MCS versus conventional collection.
The Haemonetics Multicomponents System (MCS) cell separator allows concurrent donation of red cells in addition to platelets and/or plasma, thus increasing the versatility of apheresis donations. In vivo survival of autologous red cells obtained by MCS was compared with red cells collected conventionally. In this cross-over controlled study, five male volunteers donated one unit of red cells by MCS and one unit of whole blood by the conventional manual method, 3 months apart. After storing donations in SAG-M for 35 days under standard conditions, radioactive (51Cr)-labelled autologous red cells were injected into each donor. The post-transfusion recovery (PTR) of red cells at 24 and 48 h did not show any significant difference between red cells obtained manually and by MCS, indicating that processing differences have no detrimental effects on red cell survival.
Regan
F
F
North London Blood Centre, Colindale, UK.
Teesdale
P
P
Garner
S
S
Callaghan
T
T
Brennan
M
M
Contreras
M
M
D001782:Blood Donors; D001793:Blood Preservation; D001800:Blood Specimen Collection / Q000379:methods*; D002469:Cell Separation / Q000295:instrumentation / Q000379:methods; D002470:Cell Survival; D017707:Erythrocyte Transfusion; D006801:Humans; D008297:Male