The effect of thiola, piroxicam and diltiazem on the uterine contractility of gamma-irradiated rats.
Accidental radiation exposure raises concern for functional modifications in the uterine physiology. In the current work, total body gamma-irradiation (0.7, 1.4 and 2.1 Gy) of non-pregnant adult female albino rats increased significantly the frequency and amplitude of uterine contractions in vivo. Administration of Thiola (a sulfhydryl containing agent) in doses of 100 or 250 mg kg-1, pre-irradiation or Piroxicam (a potent prostaglandin inhibitor) in a dose of 2 mg kg-1, pre- or post-irradiation failed to normalize the changes induced by gamma-irradiation. However, administration of Diltiazem (a Ca2+ channel blocker, 8 mg kg-1) pre- or post-irradiation caused a significant decrease in the frequency of uterine contractions (21% and 24% respectively) in comparison to the uterotonic pattern of gamma-irradiation alone. The results indicate a promising tocolytic activity of Diltiazem against the uterotonic effect of gamma-radiation.
Elsayed
E M
EM
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt.
Ramadan
L A
LA
Abdel Aziz
A A
AA
Moustafa
A M
AM
Hamada
F M
FM
D000818:Animals; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D004110:Diltiazem / Q000494:pharmacology*; D005260:Female; D005720:Gamma Rays; D010894:Piroxicam / Q000494:pharmacology*; D011448:Prostaglandin Antagonists / Q000494:pharmacology*; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D051381:Rats; D008625:Tiopronin / Q000494:pharmacology*; D014590:Uterine Contraction / Q000187:drug effects / Q000528:radiation effects*; D014916:Whole-Body Irradiation
D002121:Calcium Channel Blockers; D011448:Prostaglandin Antagonists; D011837:Radiation-Protective Agents; D010894:Piroxicam; D008625:Tiopronin; D004110:Diltiazem