title: Acquired angioedema.
abstract: Acquired angioedema (AAE) is a rare disorder that has been categorized into two forms, AAE-I and AAE-II. AAE-I is associated with other diseases, most commonly B-cell lymphoproliferative disorders. AAE-II is defined by the presence of an autoantibody directed against the C1-inhibitor molecule. Differentiating AAE-I from AAE-II is vital because different therapeutic interventions are required for each type. This review summarizes the clinical aspects, pathophysiology, and management of AAE compared with the types of hereditary angioedema.
authors.affiliation: Department of Medicine, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Camden 08053, USA.
authors.forename: W R
authors.initials: WR
authors.lastname: Heymann
mesh_terms: D000799:Angioedema / Q000150:complications / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D003174:Complement C1 Inactivator Proteins / Q000235:genetics; D006801:Humans
chemical_list: D003174:Complement C1 Inactivator Proteins