title: PET imaging of maze processing.
abstract: Covered maze traversal models nonverbal planning, involving sequential execution of moves using learned spatial maps. To determine the neural substrate involved in maze processing, eleven adults underwent [H(2)15O]-PET while performing motor control, following the computer; visual control, choosing the wall with more dead-ends; uncovered maze, traversing fully visible mazes; covered maze, traversing mazes only locally visible. Maze processing lateralizes to the right hemisphere: uncovered maze versus controls revealed area 23 and 29 activation; covered maze versus controls activated areas 8, 10 and 19. The extrastriate region may store path information, evoked by prefrontal areas for spatial planning and navigation.
authors.affiliation: Cognitive Neuroscience Section, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland 20892, USA.
authors.forename: S
authors.initials: S
authors.lastname: Flitman
authors.forename: J
authors.initials: J
authors.lastname: O'Grady
authors.forename: V
authors.initials: V
authors.lastname: Cooper
authors.forename: J
authors.initials: J
authors.lastname: Grafman
mesh_terms: D000293:Adolescent; D000328:Adult; D002560:Cerebrovascular Circulation / Q000502:physiology*; D003463:Cues; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D018782:Maze Learning / Q000502:physiology*; D011939:Mental Recall / Q000502:physiology; D009483:Neuropsychological Tests; D011597:Psychomotor Performance / Q000502:physiology; D013028:Space Perception / Q000502:physiology*; D014055:Tomography, Emission-Computed; D014785:Vision, Ocular / Q000502:physiology