title: Membranous obstruction of the inferior vena cava in a patient with factor V Leiden: evidence for a post-thrombotic aetiology.
abstract: BACKGROUND
  Membranous obstruction of the inferior vena cava is a rare cause of hepatic venous outflow obstruction in Caucasians. There has been much debate in the literature about its aetiology.
  
  
  RESULTS
  We describe a Caucasian with hepatic venous outflow obstruction due to an inferior vena cava web, who was found to have hypercoagulability due to factor V Leiden. Following balloon rupture of the membrane and anticoagulation, his symptoms resolved and he has remained well for a year.
  
  
  CONCLUSIONS
  The age at presentation in this patient, the presence of hypercoagulability and the excellent response to membrane rupture and anticoagulation suggest that in this case the membrane may have been derived from organised thrombus. Balloon rupture of the membrane and anticoagulation appears to be an effective treatment in such cases.
authors.affiliation: Department of Liver Transplantation and Hepatobiliary Medicine, Royal Free Hospital, London, UK.
authors.forename: C
authors.initials: C
authors.lastname: Blanshard
authors.forename: G
authors.initials: G
authors.lastname: Dodge
authors.forename: J
authors.initials: J
authors.lastname: Pasi
authors.forename: M
authors.initials: M
authors.lastname: Ormiston
authors.forename: R
authors.initials: R
authors.lastname: Dick
authors.forename: A K
authors.initials: AK
authors.lastname: Burroughs
mesh_terms: D000925:Anticoagulants / Q000627:therapeutic use; D001778:Blood Coagulation Disorders / Q000097:blood / Q000150:complications*; D006502:Budd-Chiari Syndrome / Q000097:blood / Q000150:complications; D002404:Catheterization; D005165:Factor V / Q000378:metabolism*; D005500:Follow-Up Studies; D006504:Hepatic Veno-Occlusive Disease / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D011486:Protein C / Q000378:metabolism; D014682:Vena Cava, Inferior; D014859:Warfarin / Q000627:therapeutic use
chemical_list: D000925:Anticoagulants; D011486:Protein C; C095381:factor V Leiden; D014859:Warfarin; D005165:Factor V