Analysis of the cellular mechanism for halothane inhibition of brown adipose tissue thermogenesis.
In the present studies, halothane is demonstrated to have a general inhibitory effect on norepinephrine-induced cAMP accumulation, lipolysis and rate of oxygen consumption, but no obvious effect on the respiratory capacity of isolated mitochondria. Further studies are necessary to elucidate these effects of halothane on brown adipose tissue nonshivering thermogenesis. Such studies may contribute to the understanding of the molecular effects of volatile anesthetics.
Ohlson
K B
KB
Wenner-Gren Institute, Arrhenius Laboratories F3 Stockholm University, Sweden.
Lindahl
S G
SG
Cannon
B
B
Nedergaard
J
J
D015124:8-Bromo Cyclic Adenosine Monophosphate / Q000494:pharmacology; D002001:Adipose Tissue, Brown / Q000378:metabolism*; D000818:Animals; D001833:Body Temperature Regulation / Q000187:drug effects*; D002478:Cells, Cultured; D005576:Colforsin / Q000494:pharmacology; D000242:Cyclic AMP / Q000378:metabolism; D004734:Energy Metabolism / Q000187:drug effects; D005990:Glycerol / Q000378:metabolism; D006221:Halothane / Q000494:pharmacology*; D008053:Lipid Mobilization / Q000187:drug effects; D008928:Mitochondria / Q000378:metabolism; D009638:Norepinephrine / Q000502:physiology; D010101:Oxygen Consumption / Q000187:drug effects; D011943:Receptors, Adrenergic, beta / Q000187:drug effects; D013806:Theophylline / Q000494:pharmacology
D011943:Receptors, Adrenergic, beta; D005576:Colforsin; D015124:8-Bromo Cyclic Adenosine Monophosphate; D013806:Theophylline; D000242:Cyclic AMP; D005990:Glycerol; D006221:Halothane; D009638:Norepinephrine