title: Clinically defined vascular depression.
abstract: OBJECTIVE
  The authors' goal was to examine the clinical presentation of a group of depressed elderly patients with clinically defined risk factors for vascular depression compared with a group of elderly depressed patients without such risk factors.
  
  
  METHODS
  Cognitive deficits, disability, and depressive symptoms were examined in 33 consecutively recruited elderly patients defined as having vascular depression and 32 patients defined as having nonvascular depression according to their scores on the Cumulative Illness Rating Scale-Geriatrics.
  
  
  RESULTS
  The patients with vascular depression had greater overall cognitive impairment and disability than those with nonvascular depression. Fluency and naming were more impaired in patients with vascular depression, and they had more retardation and less agitation as well as less guilt feelings and greater lack of insight.
  
  
  CONCLUSIONS
  The symptoms of vascular depression are consistent with lesions that may damage striato-pallido-thalamo-cortical pathways and other areas. The concept of vascular depression can provide the impetus for investigations of prevention and treatment of cerebrovascular disease and for studies of the course of vascular depression and selection of antidepressants.
authors.affiliation: Cornell University Medical College, New York, USA.
authors.forename: G S
authors.initials: GS
authors.lastname: Alexopoulos
authors.forename: B S
authors.initials: BS
authors.lastname: Meyers
authors.forename: R C
authors.initials: RC
authors.lastname: Young
authors.forename: T
authors.initials: T
authors.lastname: Kakuma
authors.forename: D
authors.initials: D
authors.lastname: Silbersweig
authors.forename: M
authors.initials: M
authors.lastname: Charlson
mesh_terms: D017668:Age of Onset; D000368:Aged; D002561:Cerebrovascular Disorders / Q000175:diagnosis*; D003072:Cognition Disorders / Q000175:diagnosis; D003866:Depressive Disorder / Q000175:diagnosis*; D003937:Diagnosis, Differential; D004185:Disability Evaluation; D005260:Female; D015577:Geriatric Assessment; D006167:Guilt; D006801:Humans; D008297:Male; D011569:Psychiatric Status Rating Scales / Q000706:statistics & numerical data; D011595:Psychomotor Agitation / Q000175:diagnosis; D011596:Psychomotor Disorders / Q000175:diagnosis; D012720:Severity of Illness Index