title: Elevated levels of circulating soluble adhesion molecules in patients with nonrheumatic aortic stenosis.
abstract: Increased serum levels of soluble adhesion molecules are found in various disorders of inflammatory or immunologic etiology. We found elevated levels of the soluble adhesion molecules ICAM-1, VCAM-1, and E-selectin in patients with nonrheumatic aortic stenosis, suggesting that inflammation may be important in the pathogenesis of this condition, which is generally believed to be degenerative.
authors.affiliation: Department of Cardiology, St. James's Hospital, Dublin, Republic of Ireland.
authors.forename: C N
authors.initials: CN
authors.lastname: Shahi
authors.forename: N K
authors.initials: NK
authors.lastname: Ghaisas
authors.forename: M
authors.initials: M
authors.lastname: Goggins
authors.forename: B
authors.initials: B
authors.lastname: Foley
authors.forename: P
authors.initials: P
authors.lastname: Crean
authors.forename: D
authors.initials: D
authors.lastname: Kelleher
authors.forename: M
authors.initials: M
authors.lastname: Walsh
mesh_terms: D001024:Aortic Valve Stenosis / Q000097:blood* / Q000209:etiology; D016022:Case-Control Studies; D019040:E-Selectin / Q000097:blood*; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D019010:Vascular Cell Adhesion Molecule-1 / Q000097:blood*
chemical_list: D019040:E-Selectin; D019010:Vascular Cell Adhesion Molecule-1; D018799:Intercellular Adhesion Molecule-1