E2A-Pbx1 induces growth, blocks differentiation, and interacts with other homeodomain proteins regulating normal differentiation.
Kamps
M P
MP
Department of Pathology, University of California, San Diego, School of Medicine, La Jolla 92093-0612, USA.
D000818:Animals; D001402:B-Lymphocytes / Q000473:pathology*; D002454:Cell Differentiation / Q000502:physiology*; D002455:Cell Division; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics / Q000648:ultrastructure; D002888:Chromosomes, Human, Pair 19 / Q000235:genetics / Q000648:ultrastructure; D004247:DNA / Q000235:genetics / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000235:genetics / Q000502:physiology*; D018507:Gene Expression Regulation, Developmental; D015973:Gene Expression Regulation, Leukemic; D005801:Genes, Homeobox; D018398:Homeodomain Proteins / Q000145:classification / Q000235:genetics / Q000502:physiology*; D006801:Humans; D046911:Macromolecular Substances; D051379:Mice; D005810:Multigene Family; D014411:Neoplastic Stem Cells / Q000473:pathology*; D015514:Oncogene Proteins, Fusion / Q000235:genetics / Q000502:physiology*; D000075062:Pre-B-Cell Leukemia Transcription Factor 1; D015452:Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics* / Q000473:pathology; D011485:Protein Binding; D011518:Proto-Oncogene Proteins / Q000235:genetics / Q000502:physiology*; D013045:Species Specificity; D014158:Transcription, Genetic; D014178:Translocation, Genetic; D014714:Vertebrates / Q000235:genetics / Q000378:metabolism
D004268:DNA-Binding Proteins; D018398:Homeodomain Proteins; D046911:Macromolecular Substances; D015514:Oncogene Proteins, Fusion; D000075062:Pre-B-Cell Leukemia Transcription Factor 1; D011518:Proto-Oncogene Proteins; C083400:PBX1 protein, human; C089847:E2A-Pbx1 fusion protein; D004247:DNA