title: Pathway specificity of l-isoproterenol indicates beta-adrenergic modulation of the Schaffer collateral pathway in field CA1 in the rat hippocampal slice.
abstract: Behavioral relevance of norepinephrine is associated with neuronal processing underlying arousal, affect, attention, learning and memory, and is associated with beta-adrenergic modifications of neuronal activation in the hippocampal formation. This study utilized l-isoproterenol to initiate pathway-specific activation of afferents to hippocampal CA1 pyramidal cells. The consistent effects of l-isoproterenol on the initiation of action potentials to field CA1 pyramidal neurons to single-pulse stimulation was repeatedly associated with the activation of the Schaffer collateral pathway. In contrast, l-isoproterenol plus single-pulse stimulation never elicited action potential initiation of the perforant pathway to CA1. We interpret these results as indicating that beta-adrenergic modification underlies the augmentation of information processing via the Schaffer collateral pathway in the trisynaptic circuit vs the direct perforant pathway.
authors.affiliation: School of Human Development and Communication Sciences, University of Texas at Dallas, USA.
authors.forename: V
authors.initials: V
authors.lastname: Nejtek
authors.forename: D
authors.initials: D
authors.lastname: Dahl
mesh_terms: D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D001640:Bicuculline / Q000031:analogs & derivatives / Q000494:pharmacology; D004558:Electric Stimulation; D006624:Hippocampus / Q000187:drug effects / Q000502:physiology*; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000494:pharmacology*; D008297:Male; D017966:Pyramidal Cells / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D011943:Receptors, Adrenergic, beta / Q000502:physiology*; D009435:Synaptic Transmission / Q000187:drug effects; D013997:Time Factors
chemical_list: D011943:Receptors, Adrenergic, beta; C017069:bicuculline methiodide; D007545:Isoproterenol; D001640:Bicuculline