title: Fibrolipomatous hamartoma: MR imaging findings.
abstract: OBJECTIVE
  To analyze the MR imaging features of fibrolipomatous hamartoma (FLH) of nerves.
  
  
  METHODS
  MR imaging studies from six patients (three men and three women) were retrospectively reviewed by three musculoskeletal radiologists. In four patients, a biopsy of the nerve lesion was performed. In two patients, biopsy data were unavailable and the diagnosis was based on the clinical history combined with the MR imaging findings.
  
  
  CONCLUSIONS
  MR imaging demonstrated fusiform nerve enlargement that was caused by fatty proliferation and thickening of nerve bundles. Nerve bundles appeared as serpentine tubular structures, hypointense on both T1- and T2-weighted images. The degree of fatty proliferation varied among patients. In addition, significant variation in the distribution of fat along the course of the nerves was noted. In three patients, FLH followed the branching pattern of the nerves, a characteristic pathologic finding. In two patients, intramuscular fat deposition (biceps and tibialis posterior muscles) was present. MR imaging findings of FLH are typical, allowing a confident diagnosis. The variation of fatty proliferation among patients and involved nerves as well as the tendency of the abnormalities to follow the branching pattern of the nerves is well demonstrated with MR imaging. FLH may present as an isolated nerve lesion, may be associated with intramuscular fat deposition, or may occur as a feature of macrodystrophia lipomatosa (MDL).
authors.affiliation: Department of Radiology, Veterans Affairs Medical Center and University of California, San Diego 92161, USA.
authors.forename: M
authors.initials: M
authors.lastname: De Maeseneer
authors.forename: S
authors.initials: S
authors.lastname: Jaovisidha
authors.forename: L
authors.initials: L
authors.lastname: Lenchik
authors.forename: D
authors.initials: D
authors.lastname: Witte
authors.forename: M E
authors.initials: ME
authors.lastname: Schweitzer
authors.forename: D J
authors.initials: DJ
authors.lastname: Sartoris
authors.forename: D
authors.initials: D
authors.lastname: Resnick
mesh_terms: D000328:Adult; D005260:Female; D006222:Hamartoma / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008475:Median Nerve / Q000473:pathology; D008875:Middle Aged; D010523:Peripheral Nervous System Diseases / Q000175:diagnosis* / Q000473:pathology; D010543:Peroneal Nerve / Q000473:pathology; D012189:Retrospective Studies; D013979:Tibial Nerve / Q000473:pathology