title: Timing of maternal-infant HIV transmission: associations between intrapartum factors and early polymerase chain reaction results. New York City Perinatal HIV Transmission Collaborative Study Group.
abstract: OBJECTIVE
  To investigate the hypothesis that labour and delivery events, perinatal characteristics, and maternal factors are only associated with intrapartum HIV transmission, and not with intrauterine HIV transmission.
  
  
  METHODS
  In the New York City Perinatal HIV Transmission Collaborative Study 276 infants of HIV-infected women were followed prospectively and had results of early polymerase chain reaction (PCR) tests available. Among infected children, intrauterine infection was presumed if HIV DNA was detected by PCR in samples collected from children aged < or = 3 days, and intrapartum infection was presumed if HIV DNA was not detected in these early samples. The proportion of infants with presumed intrauterine and intrapartum infections were compared by selected intrapartum, perinatal and maternal characteristics.
  
  
  RESULTS
  Presumed intrapartum infection was found in 7% of infants delivered by Cesarean section and, among infants delivered vaginally, those with longer duration of membrane rupture (> 4 h) were significantly more likely to have presumed intrapartum HIV infection (22%) than those with shorter duration (9%; P = 0.02). There were no differences in presumed intrauterine HIV infection by mode of delivery or longer duration of membrane rupture. Infants born preterm and small for gestational age had significantly higher risks of presumed intrapartum infection, but only those who were small for gestational age had higher risks of intrauterine infection.
  
  
  CONCLUSIONS
  Our results support the notion that selected intrapartum conditions, long duration of membrane rupture prior to delivery in particular, are independent risk factors for maternal-infant transmission, and suggest that preterm infants may be especially vulnerable to intrapartum HIV exposure.
authors.affiliation: Sergievsky Center, Columbia University, New York, NY 10032, USA.
authors.forename: L
authors.initials: L
authors.lastname: Kuhn
authors.forename: E J
authors.initials: EJ
authors.lastname: Abrams
authors.forename: P B
authors.initials: PB
authors.lastname: Matheson
authors.forename: P A
authors.initials: PA
authors.lastname: Thomas
authors.forename: G
authors.initials: G
authors.lastname: Lambert
authors.forename: M
authors.initials: M
authors.lastname: Bamji
authors.forename: B
authors.initials: B
authors.lastname: Greenberg
authors.forename: R W
authors.initials: RW
authors.lastname: Steketee
authors.forename: D M
authors.initials: DM
authors.lastname: Thea
mesh_terms: D001724:Birth Weight; D036861:Delivery, Obstetric; D005260:Female; D005500:Follow-Up Studies; D006678:HIV / Q000235:genetics / Q000302:isolation & purification; D015658:HIV Infections / Q000635:transmission*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D018445:Infectious Disease Transmission, Vertical; D016133:Polymerase Chain Reaction; D011247:Pregnancy; D011446:Prospective Studies; D013997:Time Factors