title: Partial structure, chromosome localization, and expression of the mouse Icln gene.
abstract: The molecular identities of most volume-regulated ion channel proteins and putative regulatory elements are currently unknown. Recently, a role for a nucleotide-sensitive chloride conductance regulator, ICln, in the function of a ubiquitous volume-regulated chloride channel has been suggested. Here, we report the cloning of a fragment of the mouse Icln gene and identification of probable Icln pseudogenes. The functional Icln gene was mapped independently to human chromosome 11q13.5-q14 and mouse chromosome 7 (50.3 cM). ICln mRNA was shown to be abundantly expressed and evenly distributed in all mouse tissues examined and at four stages of embryonic development, consistent with the proposed role of ICln in the regulation of a ubiquitous chloride channel.
authors.affiliation: Children's Hospital Medical Center, Harvard Medical School, Enders Building, Room 1309, 320 Longwood Avenue, Boston, Massachusetts 02115, USA.
authors.forename: K
authors.initials: K
authors.lastname: Wickman
authors.forename: M F
authors.initials: MF
authors.lastname: Seldin
authors.forename: M R
authors.initials: MR
authors.lastname: James
authors.forename: S J
authors.initials: SJ
authors.lastname: Gendler
authors.forename: D E
authors.initials: DE
authors.lastname: Clapham
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D018118:Chloride Channels / Q000737:chemistry / Q000235:genetics*; D002874:Chromosome Mapping; D017124:Conserved Sequence; D005786:Gene Expression Regulation; D006801:Humans; D051379:Mice; D008969:Molecular Sequence Data; D011506:Proteins / Q000737:chemistry / Q000235:genetics*; D016415:Sequence Alignment
chemical_list: D018118:Chloride Channels; D011506:Proteins