title: The effect of furazolidone and furaltadone on drug metabolism in rats.
abstract: This work examines the effect of oral treatment of rats with the nitrofuran drugs furazolidone (FZ) and furaltadone (F) at doses of 100, 200 and 400 mg/kg for 4 days, or F in the drinking water at concentrations of 0.1, 0.2 and 0.4% w/v for 14 days, on drug metabolism in vivo. FZ at doses of 200 and 400 mg/kg, and F at a dose of 400 mg/kg or at a concentration of 0.4% w/v in water depressed growth and prolonged pentobarbitone-induced sleeping time. Treatment also significantly increased the blood concentration of metronidazole when measured 30 and 40 min after metronidazole administration. Administration of tremorine (25 mg/kg, i.p.) to control vehicle-treated rats produced within 2-3 min tremors, piloerection, profuse salivation, defecation urination and chromodacryorrhesis (red tears). The onset of appearance of these signs was delayed to 7-12 min in rats pretreated with FZ or F (100 mg/kg, 4 days) or cimetidine (50 mg/kg, i.p.) given 45 min earlier. Taken together, these results suggest that FZ and F inhibit drug metabolism in rats. Treatment with these nitrofuran drugs may alter the disposition of certain drugs which may be given concomitantly with them.
authors.affiliation: Desert and Marine Environment Research Centre, Faculty of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates.
authors.forename: B H
authors.initials: BH
authors.lastname: Ali
authors.forename: M O
authors.initials: MO
authors.lastname: Tanira
authors.forename: A K
authors.initials: AK
authors.lastname: Bashir
mesh_terms: D000818:Animals; D000892:Anti-Infective Agents, Urinary / Q000494:pharmacology*; D001835:Body Weight / Q000187:drug effects; D004347:Drug Interactions; D005664:Furazolidone / Q000494:pharmacology*; D008297:Male; D008795:Metronidazole / Q000008:administration & dosage / Q000097:blood; D009581:Nitrofurans / Q000494:pharmacology*; D009929:Organ Size / Q000187:drug effects; D023303:Oxazolidinones; D010424:Pentobarbital / Q000008:administration & dosage / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012890:Sleep; D013737:Testis / Q000187:drug effects; D013997:Time Factors; D014202:Tremor / Q000139:chemically induced; D014203:Tremorine / Q000008:administration & dosage
chemical_list: D000892:Anti-Infective Agents, Urinary; D009581:Nitrofurans; D023303:Oxazolidinones; D008795:Metronidazole; D005664:Furazolidone; C007795:furaltadon; D010424:Pentobarbital; D014203:Tremorine