[Inhibition of secretion in pancreas surgery reduces postoperative complication rate: a meta analysis of 4 multicenter studies].
We report on a meta-analysis of four randomized, placebo-controlled, double-blind multicenter trials evaluating the role of perioperative octreotide treatment in the prevention of postoperative complications following elective pancreatic surgery. From a total of 963 patients (483 placebo, 480 octreotide), the postoperative complication rate (329 placebo, 206 octreotide) and the number of patients with postoperative complications (placebo 38%, octreotide 22%) were significantly higher in the placebo groups compared with the octreotide groups. Postoperative morality was comparable between the placebo (3.9%) and the octreotide (3.5%) groups. These data indicate that perioperative application of octreotide can prevent postoperative complications following pancreatic surgery.
Friess
H
H
Klinik für Viszerale und Transplantationschirurgie, Universität Bern, Inselspital.
Uhl
W
W
Schilling
M
M
Büchler
M W
MW
D004311:Double-Blind Method; D005500:Follow-Up Studies; D006801:Humans; D007279:Injections, Subcutaneous; D015337:Multicenter Studies as Topic; D015282:Octreotide / Q000008:administration & dosage*; D010189:Pancreatic Juice / Q000187:drug effects* / Q000378:metabolism; D011182:Postoperative Care; D011183:Postoperative Complications / Q000401:mortality / Q000517:prevention & control*; D016032:Randomized Controlled Trials as Topic; D015996:Survival Rate
D015282:Octreotide
Sekretionshemmung in der Pankreaschirurgie reduziert die postoperative Komplikationsrate: Eine Metaanalyse von vier Multizenterstudien.