title: [Resection of nephroblastoma: problems and complications--evaluation of the Nephroblastoma Study SIOP 9/GPOH].
abstract: The german SIOP 9/GPOH trial and study registered 486 patients with Wilms' tumor (1/89-3/94). Preoperative chemotherapy was the general approach. The indication for primary surgery was limited (age < 0.5 and > 16 years, uncertainty of diagnosis, emergency). Wilms' tumors were operated in 482 patients (4 died preoperatively) in 78 centres. Surgical and histological reports were analyzed concerning intra- and perioperative problems and complications. A total of 60% of pretreated and 39.8% of untreated tumors had local stage I. Nephroblastomas ruptured intraoperatively in 6.0% after pretreatment versus 11.5% in primary surgery. A tumor thrombus in the inferior vena cava complicated surgery in 3.1% of cases. A total of 14.3% of all histologically positive lymphnodes were correctly biopsied by the surgeon despite their normal macroscopic aspect. The overall rate of intra- and perioperative complications was low.
authors.affiliation: Abteilung für Kinderchirurgie, Universität Heidelberg.
authors.forename: H
authors.initials: H
authors.lastname: Roth
authors.forename: A
authors.initials: A
authors.lastname: Weirich
authors.forename: R
authors.initials: R
authors.lastname: Ludwig
authors.forename: R
authors.initials: R
authors.lastname: Daum
authors.forename: H
authors.initials: H
authors.lastname: Zimmermann
mesh_terms: D000293:Adolescent; D000328:Adult; D017024:Chemotherapy, Adjuvant; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007668:Kidney / Q000473:pathology; D007680:Kidney Neoplasms / Q000188:drug therapy / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D008297:Male; D009367:Neoplasm Staging; D009392:Nephrectomy; D012042:Registries; D015996:Survival Rate; D014057:Tomography, X-Ray Computed; D009396:Wilms Tumor / Q000188:drug therapy / Q000401:mortality / Q000473:pathology / Q000601:surgery*
vernacular_title: Die Resektion des Nephroblastoms: Probleme und Komplikationen--Auswertungen zur Nephroblastomstudie SIOP 9/GPOH.