title: Ventilation by external high-frequency oscillations improves cardiac function after coronary artery bypass grafting.
abstract: OBJECTIVE
  To compare the effects of ventilation with intermittent positive pressure and external high frequency oscillation by the Hayek Oscillator during the first 5 h after coronary artery bypass grafting.
  
  
  METHODS
  Eleven patients were randomized to intermittent positive pressure ventilation throughout the observation period (5 h), while 13 patients were initially ventilated with intermittent positive pressure ventilation, then by external high-frequency oscillations for 4 h, changing to positive pressure ventilation for the last hour.
  
  
  RESULTS
  Cardiac index, stroke volume index, right ventricular stroke work index, right ventricular end-diastolic volume index and mixed venous oxygen saturation were significantly increased during ventilation with external high-frequency oscillations, and arteriovenous oxygen content difference was significantly reduced. There were no significant inter- or intragroup differences in fluid accumulation, mean arterial blood pressure, arterial blood gases, pulmonary artery pressure, central venous pressure, pulmonary capillary wedge pressure, heart rate, systemic vascular resistance index, pulmonary vascular resistance index, intrapulmonary shunt fraction, right ventricular ejection fraction, right ventricular end-systolic volume index and left ventricular stroke work index.
  
  
  CONCLUSIONS
  Ventilation by external high-frequency oscillations increases cardiac index and improves tissue perfusion. The increased pumping of the heart is probably caused by changes of the intracardiac pressure-volume relationship. The Hayek Oscillator may have distinct cardiovascular benefits as ventilatory assistance in postoperative cardiac surgical patients.
authors.affiliation: Department of Thoracic Surgery, Karolinska Hospital, Stockholm, Sweden.
authors.forename: B
authors.initials: B
authors.lastname: Sidenö
authors.forename: J
authors.initials: J
authors.lastname: Vaage
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001026:Coronary Artery Bypass; D003326:Coronary Circulation / Q000502:physiology; D003327:Coronary Disease / Q000503:physiopathology / Q000601:surgery*; D003422:Critical Care; D006439:Hemodynamics / Q000502:physiology*; D006612:High-Frequency Ventilation; D006801:Humans; D007385:Intermittent Positive-Pressure Ventilation; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D011182:Postoperative Care; D011183:Postoperative Complications / Q000503:physiopathology*
chemical_list: D010100:Oxygen