Effect of particle shape of acetyl salicylic acid powders on gastric damages in rats.
In this study the correlation between particle shape of acetyl salicylic acid (ASA) powders and gastric damage was studied. It is highly possible that different pharmaceutical particulate systems having different shape factors, cause different damages in contact with stomach walls. In this study five types of ASA powders in the same size range with different shape factors were chosen. From different shape factors, two important known as "elongation" and "sphericity" were selected and by means of "image analyser" were quantitatively calculated. The highest measured shape factor for elongation was 5.9 and for sphericity was 3.7, and the smallest shape factor for elongation was 1.4 and for sphericity was 1.4. For animal study, a suspension of each powder was orally administered by feeding needle, and drug was entered into the stomaches of fasting rats. After four hours, rats were killed and their stomaches were observed. Maximum number of ulcers were produced by particles with corrugated flat surfaces and the least damage was produced by particles with elongated bodies. Therefore, the most important factor resulting highly intensive ulcers in rat stomach, is flaky particles with corrugated shapes.
Zolfaghari
M E
ME
Darou Pakhsh Pharmaceutical Research Center, Tehran, Iran.
Dhepour
A R
AR
Mousavi
N
N
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage* / Q000009:adverse effects*; D001241:Aspirin / Q000008:administration & dosage* / Q000009:adverse effects*; D005753:Gastric Mucosa / Q000473:pathology; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013272:Stomach Diseases / Q000139:chemically induced / Q000473:pathology*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D001241:Aspirin