title: Perioperative alterations of the thromboelastography in patients receiving one-stage bilateral total knee arthroplasty.
abstract: BACKGROUND
  Total knee arthroplasty is associated with activation of coagulation and fibrinolytic system in the perioperative period. The coagulation and fibrinolytic activation in one-stage bilateral total knee arthroplasty has not been described before. Thromboelastography is a real-time aid in the monitoring of coagulation and is clinically valuable in the evaluation of whole blood hemostasis. We evaluated the coagulation and fibrinolysis system activation during and after one-stage bilateral total knee arthroplasty by thromboelastography.
  
  
  METHODS
  Twenty patients, ASA class I-II, undergoing one stage bilateral total knee arthroplasty were included in this study. All patients received continuous spinal anesthesia with isobaric 0.2% bupivacaine. Arterial blood samples were obtained for thromboelastography in the following sequences (1) after induction of anesthesia (baseline), (2) 20 min after releasing tourniquet of the first leg (3) 20 min after releasing tourniquet of the second leg, (4) 2 h postoperatively, (5) 24 h postoperatively.
  
  
  RESULTS
  There was a significant shortening of reaction time (R value) after deflation of the first leg tourniquet, and a further decrease of R value after deflation of the second leg tourniquet and two hours postoperatively. The perioperative change of coagulation time was similar to that of R value. The maximum amplitude decreased after releasing tourniquet of the second leg and two hours postoperatively.
  
  
  CONCLUSIONS
  The activation of coagulation, as monitored by thromboelastography, is predominant in one-stage bilateral total knee arthroplasty after releasing tourniquet of the second leg and returns to baseline 24 h postoperatively.
authors.affiliation: Department of Anesthesiology, National Taiwan University Hospital, Taipei, R.O.C.
authors.forename: H W
authors.initials: HW
authors.lastname: Hsu
authors.forename: C H
authors.initials: CH
authors.lastname: Huang
authors.forename: Y
authors.initials: Y
authors.lastname: Chang
authors.forename: R L
authors.initials: RL
authors.lastname: Shih
authors.forename: L K
authors.initials: LK
authors.lastname: Chen
authors.forename: T L
authors.initials: TL
authors.lastname: Chen
mesh_terms: D000368:Aged; D001777:Blood Coagulation; D005260:Female; D006801:Humans; D007720:Knee Prosthesis; D008297:Male; D008875:Middle Aged; D013916:Thrombelastography