Low mitochondrial glycerophosphate dehydrogenase activity in lymphocytes of women with gestational diabetes.
An abnormally low activity of mitochondrial FAD-linked glycerophosphate dehydrogenase (m-GDH), relative to the paired measurement of glutamate dehydrogenase, was found in CD3+ lymphocytes from 4 out of 14 mothers with gestational diabetes mellitus, but in none of 36 control mothers. The low m-GDH activity coincided with an abnormally high incidence of familial history for non-insulin-dependent diabetes. These findings are compatible with the view that an inherited or acquired defect of m-GDH may participate to the pathogenesis of beta-cell dysfunction in a subgroup of patients with gestational diabetes.
Vidal
J
J
Endocrinology Unit, Hospital Clinic, Barcelona, Spain.
Corominola
H
H
Cardona
F
F
Levy
I
I
Cararach
V
V
Gomis
R
R
Malaisse
W J
WJ
D000328:Adult; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology; D016640:Diabetes, Gestational / Q000201:enzymology*; D005260:Female; D005993:Glycerolphosphate Dehydrogenase / Q000378:metabolism*; D006801:Humans; D015994:Incidence; D007515:Islets of Langerhans / Q000201:enzymology; D008214:Lymphocytes / Q000201:enzymology*; D008928:Mitochondria / Q000201:enzymology*; D011247:Pregnancy
D005993:Glycerolphosphate Dehydrogenase