title: Prognostic variables and results of salvage treatment in Hodgkin's disease.
abstract: Treatment results and prognostic variables were studied in 549 adult patients with Hodgkin's disease after first-line and salvage treatment. After first-line treatment, 479 out of 549 patients (87%) achieved complete remission (CR). During a mean observation time of 74 months, 99 patients (21%) relapsed. Sixty-nine patients (70% of relapsed patients) achieved a second CR. Variables predicting poor response (< CR) and shortened survival after first-line treatment were advanced disease, B-symptoms and age >60 years. In relapsing patients, age >60 years, relapse within 12 months and non-CR after relapse treatment predicted a poor prognosis, and none of these patients were alive after 10 years. Localized disease at diagnosis and relapse, and relapse later than 24 months predicted a good prognosis with 10-year survival after relapse of 68% and 57%, respectively. Patients with a second relapse had 5-year survival of 28% and 10-year survival of 14%. Based on the prognostic variables at first-line treatment and at relapse, selection of patients to more intensive treatment is discussed.
authors.affiliation: Department of Oncology, The Norwegian Radium Hospital, Oslo.
authors.forename: A F
authors.initials: AF
authors.lastname: Abrahamsen
authors.forename: E
authors.initials: E
authors.lastname: Hannisdal
authors.forename: O
authors.initials: O
authors.lastname: Nome
authors.forename: R F
authors.initials: RF
authors.lastname: Elgio
authors.forename: H
authors.initials: H
authors.lastname: Holte
authors.forename: B
authors.initials: B
authors.lastname: Hager
authors.forename: R
authors.initials: R
authors.lastname: Langholm
authors.forename: S
authors.initials: S
authors.lastname: Kvaløy
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D005260:Female; D006689:Hodgkin Disease / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D011379:Prognosis; D018714:Radiotherapy, Adjuvant; D012189:Retrospective Studies; D016879:Salvage Therapy; D016019:Survival Analysis; D013997:Time Factors; D016896:Treatment Outcome