c-Jun and GST-pi expression in human plasma cells.
Bone marrow samples from 33 patients affected by MM and MGUS, and 8 patients not affected by lymphoproliferative diseases were studied for expression of c-Jun (a component of the transcription factor AP-1) and glutathione-S-transferase pi (GST-pi) using immunocytochemical methods. A high and frequent expression of these two proteins was found both in MM and MGUS patients (31/33 patients positive for c-Jun and 29/33 patients positive for GST-pi) and in controls not affected by monoclonal gammopathy (7/8 patients positive for both c-Jun and GST-pi). No statistically significant correlation was found between c-Jun- and GST-pi-positive plasma cells. The expression of these two proteins was not related to clinical or laboratory data. Our results seem to confirm a possible role of the transcriptional complex AP-1 in activating GST-pi promoter in human plasma cells.
Di Simone
D
D
Department of Oncology, University of Pisa, Italy.
Galimberti
S
S
Mattii
L
L
Petrini
M
M
D000368:Aged; D004790:Enzyme Induction; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D016758:Genes, jun; D005982:Glutathione Transferase / Q000096:biosynthesis* / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000378:metabolism / Q000473:pathology; D009363:Neoplasm Proteins / Q000096:biosynthesis* / Q000235:genetics; D014411:Neoplastic Stem Cells / Q000378:metabolism*; D010265:Paraproteinemias / Q000378:metabolism* / Q000473:pathology; D010950:Plasma Cells / Q000378:metabolism*; D016755:Proto-Oncogene Proteins c-jun / Q000096:biosynthesis*; D018808:Transcription Factor AP-1 / Q000096:biosynthesis* / Q000235:genetics
D009363:Neoplasm Proteins; D016755:Proto-Oncogene Proteins c-jun; D018808:Transcription Factor AP-1; D005982:Glutathione Transferase