title: Management and design of the maintenance of SAM mouse strains: an animal model for accelerated senescence and age-associated disorders.
abstract: The Senescence-Accelerated Mouse (SAM) was established by inbreeding and pedigree selection based on the life span, degree of senescence, as well as the incidence and degree of several age-associated disorders. At first, SAM strains were developed under conventional conditions, but now some strains are also maintained under specific pathogen-free conditions. There are many methods used to maintain such strains of mice; our methods will be introduced as one example of how to develop and maintain strains of mice used in aging research.
authors.affiliation: Department of Senescence Biology, Kyoto University, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Hosokawa
authors.forename: T
authors.initials: T
authors.lastname: Abe
authors.forename: K
authors.initials: K
authors.lastname: Higuchi
authors.forename: K
authors.initials: K
authors.lastname: Shimakawa
authors.forename: Y
authors.initials: Y
authors.lastname: Omori
authors.forename: T
authors.initials: T
authors.lastname: Matsushita
authors.forename: K
authors.initials: K
authors.lastname: Kogishi
authors.forename: E
authors.initials: E
authors.lastname: Deguchi
authors.forename: Y
authors.initials: Y
authors.lastname: Kishimoto
authors.forename: K
authors.initials: K
authors.lastname: Yasuoka
authors.forename: T
authors.initials: T
authors.lastname: Takeda
mesh_terms: D000375:Aging / Q000235:genetics*; D000818:Animals; D005856:Germ-Free Life; D006799:Housing, Animal; D051379:Mice; D008815:Mice, Inbred Strains; D008954:Models, Biological; D010375:Pedigree; D012641:Selection, Genetic; D013997:Time Factors