[Molecular evolutionary analysis of GB viruses and hepatitis G virus].
Recently, new blood-transfusion transmissible viruses, called hepatitis G virus(HGV) and GB virus-C(GBV-C), have been reported. It was found that two viruses were independent isolates of the same virus, the genomic structure resembled that of flavivirus family, and GBV-C/HGV was closely related to HCV. To elucidate the evolutionary relationship between hepatitis C virus(HCV) and GBV-C/HGV, we constructed the phylogenetic trees for the putative RNA helicase and the RNA-dependent RNA polymerase regions of the Flaviviridae by UPGMA. The tree showed that HCV was closely related to GB virus-B(GBV-B) and HGV was more nearer to GB virus-A(GBV-A) rather than HCV.
Ohba
K
K
Second Department of Medicine, Nagoya City University Medical School.
Mizokami
M
M
D000595:Amino Acid Sequence; D019143:Evolution, Molecular; D018067:Flaviviridae / Q000201:enzymology / Q000235:genetics*; D016174:Hepacivirus / Q000201:enzymology / Q000235:genetics; D008969:Molecular Sequence Data; D010802:Phylogeny; D020365:RNA Helicases; D012316:RNA Nucleotidyltransferases / Q000737:chemistry; D012324:RNA-Dependent RNA Polymerase / Q000737:chemistry; D017386:Sequence Homology, Amino Acid
D012316:RNA Nucleotidyltransferases; D012324:RNA-Dependent RNA Polymerase; D020365:RNA Helicases