title: Intraspecific variation of Echinococcus granulosus and related species with emphasis on their infectivity to humans.
abstract: Four species are presently recognised within the genus Echinococcus, namely Echinococcus granulosus, E. multilocularis, E. oligarthrus and E. vogeli, which are infective to humans. Evidence for strain diversity within the species E. granulosus, previously mainly based on morphological, biological and biochemical features, has been principally confirmed by recent genetic studies. Several molecular techniques are now available which allow the identification of E. granulosus strains. Epidemiological evidence and molecular studies indicate that the so-called sheep, cattle and cervid strains of E. granulosus are infective to humans, while the horse, camel and pig strains may be less or not infective, but this question warrants further studies. A recent study indicates that E. granulosus infecting patients in Poland shares close molecular affinity with a genotype of pig origin (G7) but exhibits some clear differences. Therefore, it may represent a previously undescribed genotype of E. granulosus, designated as G9. Phylogenetic analysis of molecular data has demonstrated the need to reappraise the taxonomic status of currently recognised strains. Clear evidence for strain variation in the other species of Echinococcus does not exist at present.
authors.affiliation: Institute of Parasitology, University of Zürich, Switzerland. jeckert@vetparas.unizh.ch
authors.forename: J
authors.initials: J
authors.lastname: Eckert
authors.forename: R C
authors.initials: RC
authors.lastname: Thompson
mesh_terms: D000818:Animals; D004446:Echinococcus / Q000145:classification* / Q000472:pathogenicity*; D006801:Humans; D013045:Species Specificity