title: Elevation of serum creatine kinase during treatment with antithyroid drugs in patients with hyperthyroidism due to Graves disease. A novel side effect of antithyroid drugs.
abstract: We describe 4 patients with Graves disease who had abnormal increases of serum creatine kinase (CK) concentrations during treatment with antithyroid medications. Three of the patients experienced myalgia and muscle cramps. All of the patients manifested an increase in serum CK levels 1 to 3 months after the administration of antithyroid drugs. Thyrotropin concentrations and cardiac systolic time indexes during the elevation of serum CK concentrations were not consistent with hypothyroidism. The mechanisms are not obvious, but it is likely that the rapid decrease of thyroid hormones in tissues may temporarily cause hypothyroid states, resulting in alterations in CK concentrations. It is suggested that hasty correction of thyrotoxicosis should be avoided in susceptible patients, unless the thyrotoxic conditions are critical.
authors.affiliation: Department of Geriatrics, Shinshu University School of Medicine, Matsumoto, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Suzuki
authors.forename: K
authors.initials: K
authors.lastname: Ichikawa
authors.forename: M
authors.initials: M
authors.lastname: Nagai
authors.forename: M
authors.initials: M
authors.lastname: Mikoshiba
authors.forename: J
authors.initials: J
authors.lastname: Mori
authors.forename: A
authors.initials: A
authors.lastname: Kaneko
authors.forename: R
authors.initials: R
authors.lastname: Sekine
authors.forename: N
authors.initials: N
authors.lastname: Asanuma
authors.forename: M
authors.initials: M
authors.lastname: Hara
authors.forename: Y
authors.initials: Y
authors.lastname: Nishii
authors.forename: K
authors.initials: K
authors.lastname: Yamauchi
authors.forename: T
authors.initials: T
authors.lastname: Aizawa
authors.forename: K
authors.initials: K
authors.lastname: Hashizume
mesh_terms: D000328:Adult; D013956:Antithyroid Agents / Q000009:adverse effects* / Q000627:therapeutic use; D003402:Creatine Kinase / Q000097:blood* / Q000187:drug effects*; D005260:Female; D006111:Graves Disease / Q000097:blood* / Q000150:complications*; D006801:Humans; D006980:Hyperthyroidism / Q000097:blood* / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D008713:Methimazole / Q000009:adverse effects* / Q000627:therapeutic use; D013963:Thyroid Hormones / Q000097:blood
chemical_list: D013956:Antithyroid Agents; D013963:Thyroid Hormones; D008713:Methimazole; D003402:Creatine Kinase