title: Treatment of childhood leukemia.
abstract: The development of successful therapy for most children with acute lymphoblastic leukemia can be attributed to sequential clinical studies that show the importance of combination chemotherapy, sanctuary-specific treatment, and supportive care measures. The relative resistance of acute myelogenous leukemia to chemotherapy led to strategies that include dose-intensified chemotherapy and bone marrow transplantation. The improvement in long-term survival for children with acute leukemia has been gratifying but also has been associated with late effects that underscore the need for careful follow-up and for designing risk-adapted therapies.
authors.affiliation: Harvard Medical School, Dana-Farber Cancer Institute, Children's Hospital, Boston, MA 02215, USA.
authors.forename: L B
authors.initials: LB
authors.lastname: Silverman
authors.forename: H J
authors.initials: HJ
authors.lastname: Weinstein
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D016026:Bone Marrow Transplantation; D002648:Child; D002869:Chromosome Aberrations; D002986:Clinical Trials as Topic; D003131:Combined Modality Therapy; D016371:Cranial Irradiation; D004334:Drug Administration Schedule; D006801:Humans; D016130:Immunophenotyping; D007938:Leukemia / Q000188:drug therapy / Q000235:genetics / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy / Q000628:therapy*; D017254:Leukemic Infiltration / Q000134:cerebrospinal fluid / Q000517:prevention & control; D008578:Meninges / Q000473:pathology; D015337:Multicenter Studies as Topic; D011379:Prognosis; D012008:Recurrence; D012074:Remission Induction; D012307:Risk Factors; D016896:Treatment Outcome