[A comparative evaluation of the efficacy of different methods for the decorporation of plutonium from the respiratory organs].
The behavior of plutonium in the organism and the mechanism of formation of absorbed doses in rats of different age were studied in a comparative aspect. The efficiency of CaDTPA depending on the animal's age and the usage was estimated. Under similar conditions, the efficiency of early single injections of CaDTPA to rat cubs was 2.3 (skeleton) or 3.3 (liver) times lower than that for mature rats. Attempts of modifying the kinetics of low-transportable plutonium-239 by stimulation of pulmonary alveolar macrophages failed.
Liubchanskiĭ
E R
ER
Sokhranich
A L
AL
Sokol'nikov
M E
ME
D000042:Absorption; D000375:Aging / Q000187:drug effects / Q000528:radiation effects; D000818:Animals; D001842:Bone and Bones / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects; D002614:Chelating Agents / Q000627:therapeutic use; D003666:Decontamination / Q000379:methods*; D004353:Drug Evaluation, Preclinical; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects; D004369:Pentetic Acid / Q000627:therapeutic use; D011005:Plutonium / Q000493:pharmacokinetics / Q000633:toxicity*; D011833:Radiation Injuries, Experimental / Q000188:drug therapy / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012137:Respiratory System / Q000187:drug effects / Q000528:radiation effects*; D013997:Time Factors
D002614:Chelating Agents; D011005:Plutonium; D004369:Pentetic Acid
Sravnitel'naia otsenka éffektivnosti razlichnykh metodov dekorporatsii organov dykhaniia ot plutoniia.