title: The syndrome of inappropriate antidiuretic hormone secretion in a patient with Whipple's disease.
abstract: We report the case of a patient with central nervous system Whipple's disease who developed the syndrome of inappropriate antidiuretic hormone secretion (SIADH). The patient did not exhibit any gastrointestinal symptoms and initially was diagnosed based on neurologic findings and a duodenal biopsy that was positive for Tropheryma whippelii by the polymerase chain reaction. Radiologic involvement of the hypothalamus suggested Whipple's disease as the likely etiology of the syndrome of inappropriate antidiuretic hormone secretion. With antimicrobial therapy, the patient's serum sodium level and symptoms showed improvement.
authors.affiliation: Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, USA.
authors.forename: M A
authors.initials: MA
authors.lastname: Marinella
authors.forename: W
authors.initials: W
authors.lastname: Chey
mesh_terms: D039903:Actinobacteria / Q000302:isolation & purification; D004386:Duodenum / Q000382:microbiology; D006801:Humans; D007027:Hypothalamic Diseases / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy; D007177:Inappropriate ADH Syndrome / Q000188:drug therapy / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000627:therapeutic use; D008061:Whipple Disease / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy
chemical_list: D015662:Trimethoprim, Sulfamethoxazole Drug Combination