title: Carborundum, a bulk similar to dietary fibers but chemically inert, does not decrease colon carcinogenesis.
abstract: Dietary fibers might lower the risk of colorectal cancer, maybe because of their bulking effect. We tested the protection afforded by an inert bulk against carcinogenesis. Thirty rats received an azoxymethane injection and were allocated to a control diet, or to a diet supplemented with 10% carborundum. After 100 days the colons were scored for aberrant crypt foci. Compared to controls, the fecal weight was doubled in carborundum-fed rats (P < 0.001), but the aberrant crypt foci multiplicity was not changed (P = 0.92). The results do not support the hypothesis that intestinal dilution by an inert bulk can protect against colon cancer.
authors.affiliation: Ecole Nationale Vétérinaire, Laboratoire de Sécurité des Aliments, Institut National de la Recherche Agronomique, Toulouse, France.
authors.forename: D E
authors.initials: DE
authors.lastname: Corpet
authors.forename: S
authors.initials: S
authors.lastname: Taché
authors.forename: G
authors.initials: G
authors.lastname: Peiffer
mesh_terms: D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D001647:Bile Acids and Salts / Q000096:biosynthesis; D002244:Carbon / Q000378:metabolism / Q000627:therapeutic use*; D017554:Carbon Compounds, Inorganic; D003110:Colonic Neoplasms / Q000139:chemically induced / Q000517:prevention & control*; D004043:Dietary Fiber / Q000378:metabolism / Q000627:therapeutic use*; D005243:Feces / Q000737:chemistry; D005260:Female; D007413:Intestinal Mucosa / Q000187:drug effects / Q000473:pathology; D011230:Precancerous Conditions / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D051381:Rats; D011916:Rats, Inbred F344; D012825:Silicon; D017655:Silicon Compounds / Q000378:metabolism / Q000627:therapeutic use*
chemical_list: D001647:Bile Acids and Salts; D017554:Carbon Compounds, Inorganic; D004043:Dietary Fiber; D017655:Silicon Compounds; C517455:carborundum; D002244:Carbon; D000469:Alkaline Phosphatase; C022088:silicon carbide; D012825:Silicon