title: Primary radiotherapy of T1 and T2 glottic carcinoma--analysis of treatment results and prognostic factors in 223 patients.
abstract: Treatment results in 223 patients with T1 and T2 glottic carcinoma were analysed. A multivariate analysis was performed to evaluate the prognostic significance of factors related to tumour, patient and treatment. Locoregional control after radiotherapy was 90% for 129 patients with T1 tumours and 73% for 94 with T2 tumours. Disease-specific survival was 96% and 81% for patients with T1 and T2 tumours, respectively. In the multivariate analysis of locoregional control, subglottic extension contributed prognostic information to T-stage. In the univariate analysis, number of involved tumour sites, cord mobility and treatment interruption had a significant influence, which was lost in the multivariate analysis. Age gave additional prognostic information in the multivariate analysis of disease-specific survival. Significant adverse effects of radiotherapy were found in 9 patients (4%). Forty-nine patients (22%) had a second malignancy, 11 (5%) diagnosed before the glottic carcinoma.
authors.affiliation: Department of Oncology, Linköping University Hospital, Sweden.
authors.forename: C
authors.initials: C
authors.lastname: Klintenberg
authors.forename: J
authors.initials: J
authors.lastname: Lundgren
authors.forename: G
authors.initials: G
authors.lastname: Adell
authors.forename: M
authors.initials: M
authors.lastname: Tytor
authors.forename: L
authors.initials: L
authors.lastname: Norberg-Spaak
authors.forename: R
authors.initials: R
authors.lastname: Edelman
authors.forename: J M
authors.initials: JM
authors.lastname: Carstensen
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D005260:Female; D005931:Glottis; D006801:Humans; D007822:Laryngeal Neoplasms / Q000532:radiotherapy*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009378:Neoplasms, Multiple Primary; D011379:Prognosis; D011878:Radiotherapy / Q000009:adverse effects; D011879:Radiotherapy Dosage; D011881:Radiotherapy, Computer-Assisted