Impact of adrenalectomy on 5-HT6 and 5-HT7 receptor gene expression in the rat hippocampus.
Both glucocorticoid excess and decreased serotonergic (5-HT) transmission may cause depression. The recently cloned 5-HT6 and 5-HT7 receptors have high affinity for antidepressants. Here, we show that pharmacological adrenalectomy increases 5-HT6 and 5-HT7 receptor mRNA expression in specific hippocampal subfields, effects partly reversed by corticosterone replacement. Increased 5-HT6 and 5-HT7 receptor expression may provide a basis, in part, for the therapeutic actions of adrenal steroid synthesis inhibitors in resistant depression.
Yau
J L
JL
Molecular Endocrinology Laboratory, Western General Hospital, Edinburgh, UK. jy@srv0.med.ed.ac.uk
Noble
J
J
Widdowson
J
J
Seckl
J R
JR
D000315:Adrenalectomy; D000818:Animals; D016375:Antisense Elements (Genetics); D003345:Corticosterone / Q000494:pharmacology*; D015342:DNA Probes; D018891:Dentate Gyrus / Q000378:metabolism; D006624:Hippocampus / Q000378:metabolism*; D008297:Male; D017966:Pyramidal Cells / Q000378:metabolism; D012333:RNA, Messenger / Q000096:biosynthesis; D051381:Rats; D017208:Rats, Wistar; D011985:Receptors, Serotonin / Q000096:biosynthesis*; D014158:Transcription, Genetic / Q000187:drug effects
D016375:Antisense Elements (Genetics); D015342:DNA Probes; D012333:RNA, Messenger; D011985:Receptors, Serotonin; C097216:serotonin 6 receptor; C104425:serotonin 7 receptor; D003345:Corticosterone