[Mumps epidemic in the health area of Toledo with immunization intervention. Estimation of vaccine effectiveness].
BACKGROUND
The aim of this study was to describe a mumps epidemic occurred among school children in Toledo, Spain, between 1993 and 1994 were vaccination was undertaken as control measure, and to estimate vaccine efficacy under field conditions.


METHODS
Attack rates for vaccinated (at 15 months of age) and unvaccinated population were calculated. A retrospective cohort study was designed to estimate vaccine efficacy.


RESULTS
A total of 19 outbreaks in different schools were declared. 216 cases and 4,059 contacts, between 10-17 years old, were investigated. The attack rate for the school population was 5.3%. By age, the highest attack rate was for those in the 12-13 age group (7.9%). Estimated vaccine efficacy was 76% (95% confidence interval 66-87%) for the whole study population: For children among 10-13 years old it was 87% (95% confidence interval 76-93%), and 46% (95% confidence interval 20-70%) for those aged 14-17 years.


CONCLUSIONS
Vaccination is a good control measure in mumps outbreaks (the attack rate for the study population was 5.1%). Vaccine efficacy was high for the 10-13 age group and in agreement with the results of seroepidemiological studies.
Fernández de la Hoz Zeitler
K
K
Sección de Información Sanitaria y Vigilancia Epidemiológica, Delegación Provincial de Sanidad de Toledo.
García Colmenero
C
C
Puchades Belenguer
M J
MJ
Verde López
C
C
Carpintero Redondo
J L
JL
Alcázar Casanova
F
F
D000293:Adolescent; D002648:Child; D015331:Cohort Studies; D016001:Confidence Intervals; D004196:Disease Outbreaks; D005069:Evaluation Studies as Topic; D006801:Humans; D007223:Infant; D009107:Mumps / Q000453:epidemiology* / Q000517:prevention & control; D009108:Mumps Vaccine / Q000008:administration & dosage*; D012189:Retrospective Studies; D013030:Spain / Q000453:epidemiology
D009108:Mumps Vaccine
Epidemia de parotiditis en el área sanitaria de Toledo con intervención mediante inmunización. Estimación de la efectividad de la vacuna.