Thrombopoietin. A review.
The regulator of platelet count is believed to be thrombopoietin (mpl ligand). It is thought to act on the megakaryocytic lineage affecting the proliferation of committed cells, the maturation of megakaryocytes and the blood platelet levels by activation of its receptor (the c-mpl). Recently, it has been purified and sequenced. Thrombopoietin offers potential applications for treatment of thrombocytopenia.
Baatout
S
S
Laboratory of Experimental Hematology and Oncology, Catholic University of Louvain, Brussels, Belgium.
D000818:Animals; D005786:Gene Expression Regulation; D006801:Humans; D008533:Megakaryocytes / Q000378:metabolism / Q000502:physiology; D009363:Neoplasm Proteins; D010976:Platelet Count; D011518:Proto-Oncogene Proteins / Q000235:genetics / Q000378:metabolism; D018121:Receptors, Cytokine; D053628:Receptors, Thrombopoietin; D013926:Thrombopoietin / Q000187:drug effects / Q000235:genetics / Q000378:metabolism / Q000502:physiology
D009363:Neoplasm Proteins; D011518:Proto-Oncogene Proteins; D018121:Receptors, Cytokine; D053628:Receptors, Thrombopoietin; C082218:MPL protein, human; D013926:Thrombopoietin