Nitric oxide in the periendothelial area of femoral vein of the dog assessed in vivo by a porphyrinic sensor.
Nitric oxide concentration in the periendothelial are of the femoral vein in anaesthetized dogs was measured directly with a catheter- protected porphyrinic sensor. A 2- to 4-fold increase occurred in the basal NO concentration of 90 +/- 12 nM after acetylcholine injection (1-1.5 micrograms/kg). A linear correlation was found between femoral artery blood flow and NO concentration in the periendothelial area of the femoral vein. Noradrenaline decreased NO levels below the detection limit of the porphyrinic sensor (10 nM).
Gerová
M
M
Institute of Normal and Pathological Physiology, Slovak Academy of Sciences, Bratislava, Slovak Republic.
Mesáros
S
S
Kittová
M
M
Hatrik
S
S
Kristek
F
F
Malinski
T
T
D000109:Acetylcholine / Q000494:pharmacology; D000758:Anesthesia; D000818:Animals; D001783:Blood Flow Velocity; D001794:Blood Pressure / Q000187:drug effects; D004285:Dogs; D004730:Endothelium, Vascular / Q000737:chemistry* / Q000378:metabolism / Q000648:ultrastructure; D005260:Female; D005263:Femoral Artery / Q000502:physiology; D005268:Femoral Vein / Q000378:metabolism* / Q000648:ultrastructure; D005976:Glutaral; D008297:Male; D008839:Microelectrodes; D008854:Microscopy, Electron; D009569:Nitric Oxide / Q000097:blood*; D009638:Norepinephrine / Q000494:pharmacology; D011166:Porphyrins / Q000737:chemistry*; D016707:Tissue Fixation; D014662:Vasoconstrictor Agents / Q000494:pharmacology
D011166:Porphyrins; D014662:Vasoconstrictor Agents; D009569:Nitric Oxide; D000109:Acetylcholine; D005976:Glutaral; D009638:Norepinephrine