Immunopathology of onchocerciasis: a role for eosinophils in onchocercal dermatitis and keratitis.
This review has sought to demonstrate that eosinophils have an important role in the immunopathology of onchocercal dermatitis and keratitis. The most compelling evidence is the consistent presence of eosinophils and eosinophil granule proteins at the site of tissue damage, either after parasite death or direct injection of parasite antigens. A more definitive role for eosinophils in onchocercal keratitis will be determined using IL-5 gene knockout mice (an animal model of onchocercal dermatitis has yet to be established). Identification of chemoattractants and adhesion molecules necessary for eosinophil recruitment will indicate possible approaches to immune intervention.
Pearlman
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Division of Geographic Medicine, CWRU School of Medicine, Cleveland, Ohio, USA.
D000818:Animals; D000909:Antibodies, Helminth / Q000276:immunology*; D000947:Antigens, Helminth / Q000276:immunology; D003315:Cornea / Q000469:parasitology / Q000473:pathology; D004802:Eosinophilia / Q000209:etiology / Q000276:immunology; D004804:Eosinophils / Q000502:physiology*; D006168:Guinea Pigs; D006801:Humans; D015848:Interleukin-5 / Q000502:physiology; D051379:Mice; D008842:Microfilariae; D017181:Onchocerca volvulus / Q000254:growth & development / Q000276:immunology*; D009855:Onchocerciasis / Q000150:complications / Q000276:immunology* / Q000473:pathology; D015827:Onchocerciasis, Ocular / Q000150:complications / Q000276:immunology / Q000473:pathology; D011817:Rabbits; D012876:Skin Diseases, Parasitic / Q000276:immunology / Q000473:pathology; D018418:Th2 Cells / Q000276:immunology
D000909:Antibodies, Helminth; D000947:Antigens, Helminth; D015848:Interleukin-5