The human gene encoding FKBP-rapamycin associated protein (FRAP) maps to chromosomal band 1p36.2.
FKBP-rapamycin associated protein (FRAP) is a phosphatidylinositol kinase (PIK)-related kinase implicated in the inhibition of progression through G1 of the cell cycle. The PIK-related kinases are a growing family of proteins involved in cell-cycle checkpoints, DNA repair and recombination. We have mapped the human FRAP gene to chromosome 1p36.2, a region consistently deleted in neuroblastomas.
Lench
N J
NJ
Molecular Medicine Unit, University of Leeds, St. James's University Hospital, UK. desnl@stjames.leeds.ac.uk
Macadam
R
R
Markham
A F
AF
D001483:Base Sequence; D002352:Carrier Proteins / Q000235:genetics; D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1; D006801:Humans; D020104:Immunophilins; D017404:In Situ Hybridization, Fluorescence; D008969:Molecular Sequence Data; D017853:Phosphotransferases (Alcohol Group Acceptor); D058570:TOR Serine-Threonine Kinases
D002352:Carrier Proteins; D017853:Phosphotransferases (Alcohol Group Acceptor); C546842:MTOR protein, human; D058570:TOR Serine-Threonine Kinases; D020104:Immunophilins