title: Expression of nitric oxide synthase in the cerebral microvasculature after traumatic brain injury in the rat.
abstract: Reduced nicotinamide adenine dinucleotide phosphate-diaphorase (NADPHd) histochemistry and nitric oxide synthase (NOS) immunocytochemistry were performed on sections of brain after moderate traumatic brain injury. There was a pronounced increase in NADPHd reactivity and an induction of the endothelial NOS (eNOS) isoform in microvessels surrounding the cortical contusion by 24 h post-injury. This altered microvascular state may contribute to barrier breakdown and hyperemia which characterize traumatic brain injury.
authors.affiliation: Department of Neurosurgery, University of California and San Francisco General Hospital, 94110, USA.
authors.forename: C S
authors.initials: CS
authors.lastname: Cobbs
authors.forename: A
authors.initials: A
authors.lastname: Fenoy
authors.forename: D S
authors.initials: DS
authors.lastname: Bredt
authors.forename: L J
authors.initials: LJ
authors.lastname: Noble
mesh_terms: D000818:Animals; D001808:Blood Vessels / Q000201:enzymology; D001924:Brain Concussion / Q000201:enzymology*; D002560:Cerebrovascular Circulation; D004730:Endothelium, Vascular / Q000201:enzymology; D006651:Histocytochemistry; D007150:Immunohistochemistry; D008833:Microcirculation; D009252:NADPH Dehydrogenase / Q000378:metabolism; D019001:Nitric Oxide Synthase / Q000378:metabolism*; D051381:Rats
chemical_list: D019001:Nitric Oxide Synthase; D009252:NADPH Dehydrogenase