title: Clinical characteristics of severe peripheral neuropathy induced by docetaxel (Taxotere).
abstract: BACKGROUND
  Docetaxel, a semi-synthetic taxane may cause a usually mild sensory neuropathy. We describe the clinical characteristics of five patients who developed a more severe neuropathy following treatment with docetaxel.
  
  
  METHODS
  All patients were treated in phase II studies with 100 mg/m2 docetaxel in three weekly cycles, without steroid administration.
  
  
  RESULTS
  The clinical picture in these patients was dominated by a sensory neuropathy, but in one case severe weakness was present. Another patient developed Lhermitte's sign. Signs and symptoms are usually reversible after discontinuation of docetaxel administration, but in three patients symptoms worsened for some time after the end of treatment before improvement occurred.
  
  
  CONCLUSIONS
  Severe docetaxel neuropathy may especially occur following treatment with cumulative dosage over 600 mg/m2; in patients treated with this dosage a moderate or severe neuropathy may not be rare.
authors.affiliation: Department of Neuro-Oncology, Rotterdam Cancer Institute, The Netherlands.
authors.forename: P H
authors.initials: PH
authors.lastname: Hilkens
authors.forename: J
authors.initials: J
authors.lastname: Verweij
authors.forename: C J
authors.initials: CJ
authors.lastname: Vecht
authors.forename: G
authors.initials: G
authors.lastname: Stoter
authors.forename: M J
authors.initials: MJ
authors.lastname: van den Bent
mesh_terms: D000328:Adult; D000368:Aged; D000972:Antineoplastic Agents, Phytogenic / Q000009:adverse effects*; D000077143:Docetaxel; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017239:Paclitaxel / Q000009:adverse effects / Q000031:analogs & derivatives*; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced*; D043823:Taxoids
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D043823:Taxoids; D000077143:Docetaxel; D017239:Paclitaxel