Activation of group-II metabotropic glutamate receptors blocks induction of long-term potentiation and depotentiation in area CA1 of the rat in vivo.
The metabotropic glutamate receptor group-II agonist (1S,3S)-1-aminocyclopentane-1,3-dicarboxylic acid (1S,3S-ACPD; 5 microliters/10 mM, i.c.v.) prevented the induction of long-term potentiation and depotentiation in the CA1 area of the hippocampus in urethane-anaesthetised rats. These effects were prevented by the group-II metabotropic glutamate receptor antagonists alpha-methyl-(2S,3S,4S)-alpha-(carboxycyclopropyl)glycine (MCCG; 5 microliters/100 mM) and (RS)-alpha-methyl-4-tetrazolylphenylglycine (MTPG; 5 microliters/500 mM). The group-I antagonist (RS)-1-aminoindan-1,5-dicarboxylic acid (AIDA; 5 microliters/200 mM) or the group-III antagonist alpha-methyl-L-2-amino-4-phosphonobutyrate (MAP4; 5 microliters/100 mM) did not affect the block of the induction of long-term potentiation by 1S,3S-ACPD. It is concluded that activation of group-II metabotropic glutamate receptors can block both high-frequency stimulation-induced long term potentiation and low-frequency stimulation-induced depotentiation in the CA1 area in vivo.
Hölscher
C
C
Department of Pharmacology and Therapeutics, Trinity College, Dublin, Ireland. cholschr@tcd.ie
Anwyl
R
R
Rowan
M J
MJ
D000818:Animals; D003515:Cycloleucine / Q000031:analogs & derivatives / Q000494:pharmacology; D018690:Excitatory Amino Acid Agonists / Q000494:pharmacology; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology; D006624:Hippocampus / Q000187:drug effects* / Q000502:physiology; D017774:Long-Term Potentiation / Q000187:drug effects*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D018094:Receptors, Metabotropic Glutamate / Q000819:agonists* / Q000037:antagonists & inhibitors; D009435:Synaptic Transmission / Q000187:drug effects
D018690:Excitatory Amino Acid Agonists; D018691:Excitatory Amino Acid Antagonists; D018094:Receptors, Metabotropic Glutamate; D003515:Cycloleucine; C036361:1-amino-1,3-dicarboxycyclopentane