Genomic structure and organization of a Q-like gene in the GRC-G/C region of the rat.
In the rat homologue of the mouse Q/TL region, grc-G/C, a TL-like gene (RT1.N) has been identified recently. This paper reports on a Q-like gene, designated RT1.0, that maps in the same region. It contains a 5' untranslated region (UT), signal peptide, alpha 3 domain, transmembrane region, cytoplasmic domain (three exons) and 3'UT region. Comparison with mouse class-I genes shows that the greatest similarity is to the H-2Q, K, D and L genes; it is very different from the TL genes of the mouse and rat. A sequence that includes many CT repeats occurs in the 3'UT region of RT1.0 and in three to five other class I-hybridizing fragments. Thus, the MHC-linked region of the rat contains both Q-like and TL-like class-I genes.
Rushton
J J
JJ
Department of Pathology, University of Pittsburgh School of Medicine, PA 15261, USA.
Misra
D N
DN
Kunz
H W
HW
Hassett
A L
AL
Gill
T J
TJ
D000818:Animals; D002874:Chromosome Mapping; D005260:Female; D005805:Genes, MHC Class I; D016678:Genome; D008285:Major Histocompatibility Complex; D008297:Male; D051379:Mice; D009690:Nucleic Acid Conformation; D051381:Rats