Cerebral blood flow velocity and pulsation in neonatal respiratory distress syndrome and periventricular hemorrhage.
The present study addressed the hypotheses that cerebral ischemia and/or excessive cerebral blood pulsation contribute to periventricular hemorrhage in preterm newborns with respiratory distress and that the pulse width is a valuable tool to estimate the contribution of cerebral blood pulsation. These hypotheses were tested by following preterm newborns at risk for respiratory distress and periventricular hemorrhage. We monitored for cerebral blood flow velocity (CBFV), cerebral pulse width, and cerebral pulsatility index; for patent ductus arteriosus, capillary Pco2, heart rate (HR) and behavior; and for the occurrence of respiratory distress and periventricular hemorrhage (PVH). The data obtained were analyzed with linear regression with the mode of respiration (spontaneous or supported) and postnatal age as additional covariates. We observed that (a) respiratory distress, either uncomplicated or complicated by PVH, correlates with a low CBFV and a high cerebral pulsatility index; (b) PVH also correlates with a high cerebral pulse width; (c) the increased pulse width precedes the onset of the hemorrhage; and (d) these CBF alterations can be partly attributed to ductal shunting and are ameliorated by mechanical ventilation.
Mullaart
R A
RA
Paediatric Hospital, Nijmegen, The Netherlands.
Hopman
J C
JC
Rotteveel
J J
JJ
Stoelinga
G B
GB
De Haan
A F
AF
Daniëls
O
O
D000704:Analysis of Variance; D001783:Blood Flow Velocity; D016022:Case-Control Studies; D002543:Cerebral Hemorrhage / Q000503:physiopathology*; D002552:Cerebral Ventricles; D002560:Cerebrovascular Circulation / Q000502:physiology*; D004374:Ductus Arteriosus, Patent / Q000150:complications / Q000503:physiopathology; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D011674:Pulse / Q000502:physiology*; D012121:Respiration, Artificial; D012127:Respiratory Distress Syndrome, Newborn / Q000209:etiology / Q000503:physiopathology*