Effect of mild cold exposure on whole-body and net hindquarters glucose metabolism in sheep.
Isotope dilution using [U-13C]glucose was combined with measurement of hindquarters arteriovenous difference and blood flow to examine the effect of mild cold exposure on whole-body and net hindquarters glucose metabolism in sheep. Determinations were carried out in a thermoneutral environment (20 +/- 1 degrees C) and on day 5 of mild cold exposure (4 +/- 1 degrees C). Whole-body blood glucose turnover rate was 1.56 and 1.91 mg kg-1 min-1 in the thermoneutral environment and during mild cold exposure, respectively. Net hindquarters glucose uptake was 0.79 and 1.19 mg kg-1 min-1, corresponding to 50 and 61% of whole-body turnover rate, respectively. These results suggest that in sheep the contribution of glucose uptake by the hindquarters tended to increase during mild cold exposure, even though whole-body blood glucose turnover rate did not increase significantly.
Sano
H
H
Department of Bioscience and Technology, Iwate University, Morioka, Japan.
Fujita
T
T
Okoshi
Y
Y
Sasaki
M
M
Tsushida
M
M
Hara
S
S
Tomizawa
N
N
Ambo
K
K
D000818:Animals; D001783:Blood Flow Velocity / Q000502:physiology; D001831:Body Temperature / Q000502:physiology*; D001833:Body Temperature Regulation / Q000502:physiology*; D001835:Body Weight; D003080:Cold Temperature; D004734:Energy Metabolism; D005260:Female; D005947:Glucose / Q000378:metabolism*; D006339:Heart Rate / Q000502:physiology; D008297:Male; D012756:Sheep; D013696:Temperature
D005947:Glucose