Effect of the basidiomycete Poria cocos on experimental dermatitis and other inflammatory conditions.
The hydroalcoholic extract from P. cocos was examined for oral and topical anti-inflammatory activities. It proved to be active against carrageenan, arachidonic acid, tetradecanoyl phorbol acetate (TPA) acute edemas, TPA chronic inflammation and oxazolone delayed hypersensitivity in mice. Two lanostane-type triterpenes were isolated and identified by spectroscopic methods as dehydrotumulosic and pachymic acids. Their ID50 on acute TPA edema was 4.7 x 10(-3) and 6.8 x 10(-4) mumol/ear, respectively.
Cuellar
M J
MJ
Departament de Farmacologia, Facultat de Farmacia, Universitat de València, Spain.
Giner
R M
RM
Recio
M C
MC
Just
M J
MJ
Mañez
S
S
Rios
J L
JL
D000284:Administration, Oral; D000287:Administration, Topical; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D016718:Arachidonic Acid / Q000494:pharmacology; D001487:Basidiomycota / Q000737:chemistry*; D002351:Carrageenan / Q000494:pharmacology; D003872:Dermatitis / Q000188:drug therapy*; D005260:Female; D007249:Inflammation / Q000188:drug therapy*; D051379:Mice; D010936:Plant Extracts / Q000627:therapeutic use*; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology; D014315:Triterpenes / Q000008:administration & dosage / Q000627:therapeutic use
D000893:Anti-Inflammatory Agents; D010936:Plant Extracts; D014315:Triterpenes; D016718:Arachidonic Acid; D002351:Carrageenan; D013755:Tetradecanoylphorbol Acetate