Adsorption of plasma proteins to DMAA hydrogels obtained by ionizing radiation and its relationship with blood compatibility.
The interaction of plasma proteins such as albumin, gamma-globulin, and fibrinogen with the surface of graft copolymers DMAA-G-PTFE, DMAA-G-PETFE, and DMAA-G-PE obtained by radiation graft polymerization was studied. The adsorption of serum proteins was affected by the hydrophilicity of the graft copolymers. Increased albumin adsorption and decreased fibrinogen and gamma-globulin adsorption with increasing grafting levels was shown. A certain range of degrees of grafting showed an improved blood compatibility of the polymeric surfaces due to the existence of a hydrophilic/hydrophobic balance on the polymers. The results suggest that the DMAA-G-PTFE, DMAA-G-PETFE, and DMAA-G-PE graft copolymers can be used as biomaterials for long-term use in cardiovascular systems.
de Queiroz
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Escola Federal de Engenharia de Itajubá, Instituto de Ciências, MG, Brazil.
Castro
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SC
Higa
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OZ
D000178:Acrylamides / Q000737:chemistry / Q000378:metabolism*; D000327:Adsorption; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry / Q000378:metabolism; D001792:Blood Platelets / Q000378:metabolism / Q000648:ultrastructure; D002417:Cattle; D002448:Cell Adhesion / Q000502:physiology; D005340:Fibrinogen / Q000378:metabolism*; D005782:Gels / Q000528:radiation effects; D006801:Humans; D008855:Microscopy, Electron, Scanning; D016011:Normal Distribution; D010976:Platelet Count; D011095:Polyethylenes / Q000737:chemistry / Q000378:metabolism; D011108:Polymers; D011138:Polytetrafluoroethylene / Q000737:chemistry / Q000378:metabolism; D011485:Protein Binding; D012710:Serum Albumin, Bovine / Q000378:metabolism*; D013052:Spectrometry, X-Ray Emission; D014867:Water / Q000378:metabolism; D005719:gamma-Globulins / Q000378:metabolism*
D000178:Acrylamides; D001672:Biocompatible Materials; D005782:Gels; D011095:Polyethylenes; D011108:Polymers; D005719:gamma-Globulins; D014867:Water; D012710:Serum Albumin, Bovine; D005340:Fibrinogen; D011138:Polytetrafluoroethylene; C099046:N,N-dimethylacrylamide