title: Role of wavefront curvature in propagation of cardiac impulse.
abstract: It is traditionally assumed that impulse propagation in cardiac muscle is determined by the combination of two factors: (1) the active properties of cardiac cell membranes and (2) the passive electrical characteristics of the network formed by cardiac cells. However, advances made recently in the theory of generic excitable media suggest that an additional factor-the geometry of excitation wavefronts -may play an important role. In particular, impulse propagation strongly depends on the wavefront curvature on a small spatial scale. In the heart, excitation wavefronts have pronounced curvatures in several situations including waves initiated by small electrodes, waves emerging from narrow tissue structures, and waves propagating around the sharp edges of anatomical obstacles or around a zone of functional conduction block during spiral wave rotation. In this short review we consider the theoretical background relating impulse propagation to wavefront curvature and we estimate the role of wavefront curvature in electrical stimulation, formation of conduction block, and the dynamic behavior of spiral waves.
authors.affiliation: Department of Physiology, University of Berne, Switzerland. fast@pyl.unibe.ch
authors.forename: V G
authors.initials: VG
authors.lastname: Fast
authors.forename: A G
authors.initials: AG
authors.lastname: Kléber
mesh_terms: D006327:Heart Block / Q000503:physiopathology*; D006329:Heart Conduction System / Q000502:physiology*; D006801:Humans; D008955:Models, Cardiovascular