title: [Levels of pituitary-thyroid axis hormones in men during the course of chronic active hepatitis and liver cirrhosis].
abstract: Influence of liver pathology on changes in concentrations of individual thyroid hormones, in spite of extensive investigations, remains obscure and the presented opinions are conditionary. The aim of the work was to show whether impairment of liver function (cirrhosis, chronic active hepatitis CAH) affects basic concentrations of TT3, TT4, fT3, fT4 and TSH. The investigations were carried out in 30 males (mean age 51.8 years) with cirrhosis of the liver and in 30 males (mean age 38.9 years) with CAH. The diagnosis was established on the basis of the clinical picture, results of biochemical and serological blood tests, as well as on histopathological examination of liver samples. The control group consisted of 20 male healthy volunteers. Fasting blood samples were collected between 7 and 8 a.m. Concentrations of TT3, TT4, fT3, fT4 and TSH were estimated with the RIA method. A significant decline of TT3, TT4, fT3, fT4 concentration and TT3/TT4 index in males with liver cirrhosis were observed.
authors.affiliation: Katedra i Zakład Patofizjołogii Slaskiej Akademii Medycznej w Zabrzu.
authors.forename: B
authors.initials: B
authors.lastname: Marek
mesh_terms: D000328:Adult; D006521:Hepatitis, Chronic / Q000503:physiopathology*; D006801:Humans; D008103:Liver Cirrhosis / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D010907:Pituitary Hormones / Q000502:physiology; D011863:Radioimmunoassay; D013963:Thyroid Hormones / Q000502:physiology*
chemical_list: D010907:Pituitary Hormones; D013963:Thyroid Hormones
vernacular_title: Stezenie hormonów osi przysadkowo-tarczycowej u mezczyzn w przebiegu przewlekłego aktywnego zapalenia watroby i marskości watroby.