title: Immunological response in laparoscopic surgery.
abstract: Immunological response to surgical trauma may be protected during laparoscopic surgery. A less surgical trauma, in comparison with conventional surgery, may explained these important advantages. Plasma and macrophages studies have demonstrated that laparoscopic cholecystectomy causes less depression of cell mediated immunity than open cholecystectomy. What will be the impact of this immunological protection in laparoscopic advanced and oncological surgery? Experimental studies have showed that laparoscopic techniques in advanced and oncological surgery may have important advantages concerning the "preservation of the immune status" of the patient. That will imply in the future a lower percentage of infections, local recurrence and even a lower percentage of distant metastases. On the other hand, the appearance of tumor implants in the port sites after laparoscopic resection for cancer is a significant drawback of this procedure. Proper investigations have to be carried out in order to find the cause and the solution of this dilemma.
authors.affiliation: Department of Histology, Academic Hospital, Vrije Universiteit Amsterdam, The Netherlands.
authors.forename: M J
authors.initials: MJ
authors.lastname: Smit
authors.forename: R H
authors.initials: RH
authors.lastname: Beelen
authors.forename: Q A
authors.initials: QA
authors.lastname: Eijsbouts
authors.forename: S
authors.initials: S
authors.lastname: Meijer
authors.forename: M A
authors.initials: MA
authors.lastname: Cuesta
mesh_terms: D000210:Acute-Phase Reaction / Q000276:immunology*; D002763:Cholecystectomy; D017081:Cholecystectomy, Laparoscopic; D006801:Humans; D007108:Immune Tolerance; D007109:Immunity; D007121:Immunocompetence; D010535:Laparoscopy