title: Plasma deoxycholic acid is related to deoxycholic acid in faecal water.
abstract: Bile acids are considered as a risk factor for colorectal carcinogenesis. They were analysed in samples of faecal water and plasma of fasting heparine blood from 23 urolithiasis patients. Linear regression showed that the highest percentage of variance (52%) was explained by the model: plasma deoxycholic acid (micromol/l) = -3.11 + 0.96(+/-0.25*) 10log deoxycholic acid in faecal water (micromol/l) + 0.35(+/-0.15*) pH of faecal water -0.41(+/-0.19#) defacation frequency (number of stools/day); *P < 0.05, #P = 0.055. In future studies, analysing blood levels of unconjugated deoxycholic acid may substitute faecal measurements.
authors.affiliation: Department of Urology, University Hospital, Maastricht, The Netherlands.
authors.forename: A
authors.initials: A
authors.lastname: van Faassen
authors.forename: T
authors.initials: T
authors.lastname: Ochsenkühn
authors.forename: S
authors.initials: S
authors.lastname: Houterman
authors.forename: E M
authors.initials: EM
authors.lastname: van der Ploeg
authors.forename: B H
authors.initials: BH
authors.lastname: Bueno-de-Mesquita
authors.forename: M C
authors.initials: MC
authors.lastname: Ocké
authors.forename: E
authors.initials: E
authors.lastname: Bayerdörffer
authors.forename: R A
authors.initials: RA
authors.lastname: Janknegt
mesh_terms: D002756:Cholagogues and Choleretics / Q000032:analysis*; D003840:Deoxycholic Acid / Q000032:analysis* / Q000097:blood; D005243:Feces / Q000737:chemistry*; D006801:Humans
chemical_list: D002756:Cholagogues and Choleretics; D003840:Deoxycholic Acid