Kidney function in rats after 5/6 nephrectomy (5/6 NX); effort of treatment with vitamin E.
In adult female rats various kidney functions were measured 3 weeks after 5/6 nephrectomy (5/6 NX). The distinct rises in blood urea nitrogen and in renal excretion of proteins indicate the impairment of the kidney. In 5/6 NX rats, the renal excretion of creatinine, glucosaminoglycan, and of p-aminohippurate was diminished. The concentrations of hydroxypyroline and of free hydrogen ions were distinctly increased in urine samples from 5/6 NX rats. The concentration of lipid peroxides was enhanced in kidney tissue whereas 3 weeks after 5/6 NX the concentration of GSH and GSSG in the remnant kidney tissue was unchanged. Long-term administration of vitamin E increased its concentration in plasma, kidney, and liver. Nevertheless, daily treatment with vitamin E (1 or 10 mg/100 g b.w. s.c. for 5 weeks) did not reduce the degree of impairment of kidney function following 5/6 NX.
Bräunlich
H
H
Institute of Pharmacology and Toxicology, Faculty of Medicine, Friedrich Schiller University Jena, Germany.
Marx
F
F
Fleck
C
C
Stein
G
G
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D003404:Creatinine / Q000378:metabolism; D005260:Female; D005978:Glutathione / Q000378:metabolism; D006025:Glycosaminoglycans / Q000378:metabolism; D006909:Hydroxyproline / Q000378:metabolism; D007668:Kidney / Q000187:drug effects / Q000502:physiology* / Q000601:surgery; D007677:Kidney Function Tests; D008054:Lipid Peroxides / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D009392:Nephrectomy; D051381:Rats; D017208:Rats, Wistar; D014810:Vitamin E / Q000378:metabolism / Q000494:pharmacology*; D010130:p-Aminohippuric Acid / Q000378:metabolism
D006025:Glycosaminoglycans; D008054:Lipid Peroxides; C020341:glucosaminoglycans; D014810:Vitamin E; D003404:Creatinine; D005978:Glutathione; D006909:Hydroxyproline; D010130:p-Aminohippuric Acid