title: Predictive factors used to justify hysterectomy after loop conization: increasing age and severity of disease.
abstract: OBJECTIVE
  To determine the interpretability and significance of the traditional factors used to predict residual dysplasia in hysterectomy specimens after loop conization.
  
  
  METHODS
  Loop electrosurgical cervical conization was performed on 372 patients. Ninety three women had a hysterectomy within 6 months of the loop conization. Residual disease was defined as cervical intraepithelial neoplasia or cancer in the hysterectomy specimen.
  
  
  RESULTS
  Of the 93 patients having a subsequent hysterectomy, 36 (38.7%) has residual disease in their hysterectomy specimen. The mean age of the patients with residual disease in the post loop conization hysterectomy specimen was 42.22. The mean age of those free of residual disease was 29.42. By multivariate analysis, dysplasia involving the ectocervical margin (p = 0.34) and the endocervical margin (p = 0.35) was not predictive of disease in the hysterectomy specimens. Endocervical curettage (p = 0.005), glandular involvement (p = 0.01), loop conization pathology findings (p < 0.05) and cytological examination (p < 0.001) were predictive of residual dysplasia.
  
  
  CONCLUSIONS
  Cytological reports, increasing age, severity of disease, gland involvement and endocervical curettage were the only factors that accurately predicted residual dysplasia. The presence or absence of dysplasia in the loop conization, ectocervical margin and endocervical margin was not predictive of residual dysplasia in post loop conization hysterectomy specimens.
authors.affiliation: 2nd Department of Obstetrics and Gynecology, Areteion Hospital, Athens University, Greece.
authors.forename: D
authors.initials: D
authors.lastname: Kalogirou
authors.forename: G
authors.initials: G
authors.lastname: Antoniou
authors.forename: P
authors.initials: P
authors.lastname: Karakitsos
authors.forename: D
authors.initials: D
authors.lastname: Botsis
authors.forename: O
authors.initials: O
authors.lastname: Kalogirou
authors.forename: L
authors.initials: L
authors.lastname: Giannikos
mesh_terms: D000328:Adult; D000367:Age Factors; D002584:Cervix Uteri / Q000473:pathology / Q000601:surgery; D019092:Conization / Q000379:methods*; D004598:Electrosurgery / Q000379:methods; D005260:Female; D006801:Humans; D007044:Hysterectomy / Q000379:methods*; D008875:Middle Aged; D018365:Neoplasm, Residual / Q000453:epidemiology / Q000473:pathology; D011237:Predictive Value of Tests; D015995:Prevalence; D012720:Severity of Illness Index; D002578:Uterine Cervical Dysplasia / Q000473:pathology* / Q000601:surgery*; D002583:Uterine Cervical Neoplasms / Q000473:pathology* / Q000601:surgery*