title: Systemic immune response to Streptococcal and Staphylococcal lipoteichoic acids in children with recurrent tonsillitis.
abstract: The antibodies to LTA of Streptococcus pyogenes (S. pyogenes) and of Staphylococcus aureus (S. aureus) in sera from 110 children with or without recurrent tonsillitis were assayed by enzyme-linked immunosorbent assay (ELISA). The antibody of IgA class was not detected in any sera. There was a significant positive correlation between IgG and IgM antibody levels to LTA of S. pyogenes and those to LTA of S. aureus. There was no significant correlation between anti-LTA IgM antibody and age or episodes of tonsillitis. However, serum anti-LTA IgG levels in younger patients ( < or = 7 y.o.) were significantly lower than those in their elders (>7 y.o.) (anti-S. pyogenes; p = 0.0007, anti-S. aureus; p = 0.007). Serum anti-LTA IgG antibody levels correlated inversely with episodes of tonsillitis in younger patients ( < 7 y.o.) (S. pyogenes: r = -0.362, p = 0.0082, S. aureus: r = -0.276, p = 0.047). These findings suggest that systemic hyposensitivity to LTA of S. pyogenes and S. aureus may be a possible cause of habitualness of tonsillitis in young children.
authors.affiliation: Department of Otolaryngology, Sapporo Medical University, School of Medicine, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Yokoyama
authors.forename: Y
authors.initials: Y
authors.lastname: Harabuchi
authors.forename: H
authors.initials: H
authors.lastname: Kodama
authors.forename: H
authors.initials: H
authors.lastname: Murakata
authors.forename: A
authors.initials: A
authors.lastname: Kataura
mesh_terms: D002648:Child; D002675:Child, Preschool; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood*; D007074:Immunoglobulin G / Q000097:blood*; D007075:Immunoglobulin M / Q000097:blood*; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D013211:Staphylococcus aureus / Q000302:isolation & purification* / Q000472:pathogenicity; D013297:Streptococcus pyogenes / Q000302:isolation & purification* / Q000472:pathogenicity; D014069:Tonsillitis / Q000209:etiology / Q000276:immunology* / Q000382:microbiology
chemical_list: D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M