title: Evaluation of hylan b gel as a soft-tissue augmentation implant material.
abstract: BACKGROUND
  The ideal soft tissue augmentation material should be an inert, safe, volume-filling material that is easy to use and remains in place over time. Hylan b gel, a cross-linked hyaluronic acid, may have many of these characteristics.
  
  
  OBJECTIVE
  We assessed the potential value of hylan b gel as a soft tissue augmentation material.
  
  
  METHODS
  A 12-month guinea pig model was used to investigate the tissue effects of hylan b gel versus "collagen" controls.
  
  
  RESULTS
  Hylan b gel was found to be biologically compatible and stable in dermal tissues. At 1 year, only hylan b gel implants were evident (12 of 16 test sites).
  
  
  CONCLUSIONS
  In this model hylan b gel performed favorably when compared with the most commonly used soft-tissue augmentation products. The material possesses many desirable implant material characteristics.
authors.affiliation: Dermatology Clinical Research, Veterans Medical Center, San Diego, California 92161, USA.
authors.forename: D
authors.initials: D
authors.lastname: Piacquadio
authors.forename: M
authors.initials: M
authors.lastname: Jarcho
authors.forename: R
authors.initials: R
authors.lastname: Goltz
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000008:administration & dosage* / Q000009:adverse effects; D002482:Cellulose / Q000008:administration & dosage* / Q000009:adverse effects; D003094:Collagen / Q000008:administration & dosage / Q000009:adverse effects; D004338:Drug Combinations; D006168:Guinea Pigs; D006584:Hexamethonium Compounds / Q000008:administration & dosage* / Q000009:adverse effects; D006820:Hyaluronic Acid / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D007249:Inflammation / Q000473:pathology; D013047:Specific Pathogen-Free Organisms; D013635:Tantalum / Q000008:administration & dosage* / Q000009:adverse effects; D013917:Thrombin / Q000008:administration & dosage* / Q000009:adverse effects; D013997:Time Factors
chemical_list: D001672:Biocompatible Materials; D004338:Drug Combinations; D006584:Hexamethonium Compounds; C070509:hylan gel; D013635:Tantalum; D002482:Cellulose; D006820:Hyaluronic Acid; D003094:Collagen; D013917:Thrombin