title: Atypical MRI features of Wilson's disease: high signal in globus pallidus on T1-weighted images.
abstract: Most reports of MRI in Wilson's disease have been of abnormal low-signal lesions on T1-weighted images and high signal intensity on T2-weighted images. In contrast, we report three patients who had high-signal lesions in the globus pallidus on T1-weighted images, a finding seen in patients with portal-systemic encephalopathy. The possible causes include the paramagnetic effect of copper or iron and accumulation of Alzheimer type II glial cells.
authors.affiliation: Third Department of Internal Medicine, National Defense Medical College, Saitama, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Mochizuki
authors.forename: K
authors.initials: K
authors.lastname: Kamakura
authors.forename: T
authors.initials: T
authors.lastname: Masaki
authors.forename: M
authors.initials: M
authors.lastname: Okano
authors.forename: N
authors.initials: N
authors.lastname: Nagata
authors.forename: A
authors.initials: A
authors.lastname: Inui
authors.forename: T
authors.initials: T
authors.lastname: Fujisawa
authors.forename: T
authors.initials: T
authors.lastname: Kaji
mesh_terms: D000328:Adult; D000544:Alzheimer Disease / Q000175:diagnosis; D003300:Copper / Q000378:metabolism; D003937:Diagnosis, Differential; D005260:Female; D005917:Globus Pallidus / Q000473:pathology*; D006501:Hepatic Encephalopathy / Q000175:diagnosis*; D006527:Hepatolenticular Degeneration / Q000175:diagnosis*; D006801:Humans; D007501:Iron / Q000378:metabolism; D008279:Magnetic Resonance Imaging; D008297:Male; D008636:Mesencephalon / Q000473:pathology; D009457:Neuroglia / Q000473:pathology; D011699:Putamen / Q000473:pathology
chemical_list: D003300:Copper; D007501:Iron