Physical mapping of the 5 Mb D9S196-D9S180 interval harboring the basal cell nevus syndrome gene and localization of six genes in this region.
The basal cell nevus syndrome (Gorlin syndrome) is characterized by multiple basal cell carcinomas and diverse developmental defects. The gene responsible for this syndrome has been mapped previously to a 2 cM interval between D9S196 and D9S 180 at 9q22.3, and very recently mutations of a candidate gene in this region--the human homolog of the Drosophila patched gene have been identified. We report here on physical mapping studies integrating a contig of yeast artificial chromosomes and bacterial artificial chromosomes with a long-range map spanning approximately 5 Mb between the recombination-determined flanking markers. Six genes have been mapped to this interval.
Xie
J
J
Department of Dermatology, San Francisco General Hospital, California 94110, USA.
Quinn
A
A
Zhang
X
X
Bare
J
J
Rothman
A
A
Collins
C
C
Cutone
S
S
Rutter
M
M
McCormick
M K
MK
Epstein
E
E
D015067:17-Hydroxysteroid Dehydrogenases / Q000235:genetics; D000818:Animals; D001478:Basal Cell Nevus Syndrome / Q000235:genetics*; D002874:Chromosome Mapping; D018244:Chromosomes, Artificial, Yeast; D002899:Chromosomes, Human, Pair 9 / Q000235:genetics; D004330:Drosophila / Q000235:genetics; D006597:Fructose-Bisphosphatase / Q000235:genetics; D017344:Genes, Insect; D005819:Genetic Markers; D006801:Humans; D011110:Polymorphism, Genetic; D039381:RNA Cap-Binding Proteins; D016601:RNA-Binding Proteins / Q000235:genetics; D012091:Repetitive Sequences, Nucleic Acid; D012689:Sequence Homology, Nucleic Acid; D016324:Sequence Tagged Sites
D005819:Genetic Markers; D039381:RNA Cap-Binding Proteins; D016601:RNA-Binding Proteins; D015067:17-Hydroxysteroid Dehydrogenases; D006597:Fructose-Bisphosphatase