title: Intracranial Hodgkin's disease in two patients with familial Hodgkin's disease.
abstract: Intracranial Hodgkin's disease is very rare and is often a terminal event. The case of a 33-year-old man who relapsed in the anterior pituitary gland without other evidence of disease 6 months after extended field radiation therapy for Stage IIA Hodgkin's disease is presented. He remains well with no evidence of disease five years after surgery and chemotherapy for intracranial relapse. The case of a 16-year-old boy with a dural relapse of Hodgkin's disease associated with positive cerebrospinal fluid cytology is also presented. These two patients are members of different families each with multiple cases of Hodgkin's disease. Central nervous system involvement with Hodgkin's disease may be more frequent in familial Hodgkin's disease in which immune deficiency is common.
authors.affiliation: Department of Oncology, Albert Einstein Cancer Center, Bronx, New York 10467, USA.
authors.forename: M Y
authors.initials: MY
authors.lastname: Ashigbi
authors.forename: U
authors.initials: U
authors.lastname: Venkatraj
authors.forename: V
authors.initials: V
authors.lastname: Agarwal
authors.forename: J
authors.initials: J
authors.lastname: Bello
authors.forename: P H
authors.initials: PH
authors.lastname: Wiernik
mesh_terms: D000293:Adolescent; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000473:pathology / Q000628:therapy*; D003131:Combined Modality Therapy; D005192:Family Health; D017809:Fatal Outcome; D006689:Hodgkin Disease / Q000473:pathology / Q000628:therapy*; D006801:Humans; D008130:Lomustine / Q000008:administration & dosage; D008297:Male; D008942:Mitoxantrone / Q000008:administration & dosage; D012008:Recurrence; D012074:Remission Induction; D014747:Vinblastine / Q000008:administration & dosage
chemical_list: D014747:Vinblastine; D008130:Lomustine; D008942:Mitoxantrone