Borna disease virus antibodies and the deficit syndrome of schizophrenia.
We detected anti-Borna disease virus (BDV) antibodies at a 14.4% rate in patients with schizophrenia. The hypothesis of a higher rate of BDV seropositivity in deficit syndrome was borne out in a subset of 64 patients categorized according to the Schedule for the Deficit Syndrome with 5/15 seropositive deficit and 4/49 seropositive nondeficit (p < 0.05). This suggests that the antibodies and possibly a BDV-like virus are pathogenetically linked to this form of schizophrenia.
Waltrip
R W
RW
Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland at Baltimore, Catonsville 21228, USA.
Buchanan
R W
RW
Carpenter
W T
WT
Kirkpatrick
B
B
Summerfelt
A
A
Breier
A
A
Rubin
S A
SA
Carbone
K M
KM
D000328:Adult; D000342:Affective Symptoms / Q000821:virology*; D001891:Borna disease virus / Q000276:immunology*; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D003072:Cognition Disorders / Q000821:virology*; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008297:Male; D012559:Schizophrenia / Q000145:classification / Q000821:virology*; D013577:Syndrome