title: A cellular automata model of enzyme kinetics.
abstract: We have developed a cellular automata model of an enzyme reaction with a substrate in water. The model produces Michaelis-Menten kinetics with good Lineweaver-Burk plots. The variation in affinity parameters predicts that, in general, hydrophobic substrates are more reactive with enzymes, this attribute being more important than the relationship between enzyme and substrate. The ease of generation and the illustrative value of the model lead us to believe that cellular automata models have a useful role in the study of dynamic phenomena such as enzyme kinetics.
authors.affiliation: Department of Medicinal Chemistry and Mathematical Sciences, Virginia Commonwealth University, Richmond 23298, USA.
authors.forename: L B
authors.initials: LB
authors.lastname: Kier
authors.forename: C K
authors.initials: CK
authors.lastname: Cheng
authors.forename: B
authors.initials: B
authors.lastname: Testa
authors.forename: P A
authors.initials: PA
authors.lastname: Carrupt
mesh_terms: D001331:Automation; D003198:Computer Simulation; D004798:Enzymes / Q000378:metabolism*; D007700:Kinetics; D008956:Models, Chemical
chemical_list: D004798:Enzymes