Influence of zopiclone, a new generation hypnotic, on the intermediate stage and paradoxical sleep in the rat.
This study examined the influence of zopiclone, a third generation hypnotic, on the transition from slow wave sleep to paradoxical sleep (PS) which is increased at the expense of PS by barbiturates and benzodiazepines. The compound decreased sleep latency and increased the latency of the intermediate stage (IS) and PS at 2.5, 5 and 7.5 mg/kg IP. The amount of the IS was decreased because of the decrease in phase number up to 6 h at all doses. PS amount was decreased during 2 h at 2.5 mg/kg and during 4 h at 5 and 7.5 mg/kg also because of the decrease in phase number. The IS never substituted for PS. The IS spindle characteristics were not modified and the theta rhythm frequency slightly decreased at 5 mg/kg (IS) and 7.5 mg/kg (PS).
Gauthier
P
P
Laboratoire de Psychophysiologie, Faculté des Sciences, Université de Nice Sophia Antipolis, France.
Arnaud
C
C
Stutzmann
J M
JM
Gottesmann
C
C
D000818:Animals; D053961:Azabicyclo Compounds; D004569:Electroencephalography / Q000187:drug effects; D006993:Hypnotics and Sedatives / Q000494:pharmacology*; D008297:Male; D010879:Piperazines / Q000494:pharmacology*; D017286:Polysomnography; D051381:Rats; D017208:Rats, Wistar; D012894:Sleep Stages / Q000187:drug effects*; D012895:Sleep, REM / Q000187:drug effects*; D013826:Theta Rhythm / Q000187:drug effects
D053961:Azabicyclo Compounds; D006993:Hypnotics and Sedatives; D010879:Piperazines; C515050:zopiclone