title: Laparoscopic vs open appendectomy. A randomized clinical trial.
abstract: BACKGROUND
  A randomized clinical trial was performed to compare open appendectomy (OA) and laparoscopic appendectomy (LA).
  
  
  METHODS
  201 patients with similar characteristics of appendicitis were randomized to either OA or LA. Operative time and technique, reintroduction of diet, postoperative pain, use of analgesia, hospital stay, and complications were documented.
  
  
  RESULTS
  104 patients were allocated to the OA group and 97 to the LA group. Postoperative pain was significantly less in the LA group on the 1st (p < 0.001) and 2nd (p < 0.001) postoperative day, resulting in less use of analgesics on both days (p < 0.001). Restoration of diet was similar in both groups. Mean operative time was longer in the LA group: 61 vs 41 min (p < 0.001). Postoperative complications did not differ in either group, except for wound infections (six OA group vs zero LA group, p < 0.05). Mean hospital stay was similar in both groups.
  
  
  CONCLUSIONS
  LA results in less postoperative pain and fewer wound infections. The laparoscopic procedure is technically more demanding to perform, resulting in longer operative time.
authors.affiliation: Department of General Surgery, University Hospital Dijkzigt, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands.
authors.forename: G
authors.initials: G
authors.lastname: Kazemier
authors.forename: G R
authors.initials: GR
authors.lastname: de Zeeuw
authors.forename: J F
authors.initials: JF
authors.lastname: Lange
authors.forename: W C
authors.initials: WC
authors.lastname: Hop
authors.forename: H J
authors.initials: HJ
authors.lastname: Bonjer
mesh_terms: D000208:Acute Disease; D000328:Adult; D001062:Appendectomy / Q000379:methods*; D001064:Appendicitis / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D010535:Laparoscopy; D007902:Length of Stay; D008297:Male; D010149:Postoperative Pain / Q000453:epidemiology; D011183:Postoperative Complications / Q000453:epidemiology; D013997:Time Factors