title: Developmental patterns of aluminum and five essential mineral elements in the central nervous system of the fetal and infant guinea pig.
abstract: Al is found in the developing conceptus, but little information is available concerning its tissue distribution and its changes in concentration with age. Because Al has affinity for many of the same biological ligands as the essential mineral cations Ca, Mg, Zn, Fe, and Mn, we hypothesized that Al might show a pattern of developmental concentrations that was similar to one or more of these elements in the brain, a major target of Al toxicity. Concentrations of Al, Ca, Mg, Zn, Fe, and Mn were measured in spinal cord, brainstem, cerebellum, and forebrain of guinea pig fetuses on gestation day (GD) 30 and 45, at birth, and on postnatal day (PND) 3, 6, and 12. Dams were fed commercial guinea pig chow, which contained 47 micrograms Al/g. Tissue Al and Mn were measured with electrothermal atomic absorption spectrophotometry (ETAAS), and the other elements with inductively coupled axial plasma spectroscopy (ICAP-AES). Al concentrations in the brain regions were highest in spinal cord, brainstem, and cerebellum, and decreased during late gestation and lactation. Al did not show marked increases in regional brain concentrations during the final third of gestation as did Fe, Mg, and Zn. In contrast to Fe and Ca, Al did not accumulate in placenta. Al was the only element to show higher concentrations in spinal cord than in any other tissue at birth. In summary, the tissue distribution of Al did not follow that of essential cations as examined in this study.
authors.affiliation: Department of Internal Medicine, University of California, Davis, CA 95616, USA.
authors.forename: M S
authors.initials: MS
authors.lastname: Golub
authors.forename: B
authors.initials: B
authors.lastname: Han
authors.forename: C L
authors.initials: CL
authors.lastname: Keen
mesh_terms: D000535:Aluminum / Q000378:metabolism* / Q000494:pharmacology; D000704:Analysis of Variance; D000818:Animals; D000831:Animals, Newborn; D001835:Body Weight / Q000187:drug effects; D001933:Brain Stem / Q000187:drug effects / Q000196:embryology / Q000378:metabolism; D002118:Calcium / Q000378:metabolism / Q000494:pharmacology; D002490:Central Nervous System / Q000187:drug effects* / Q000196:embryology / Q000378:metabolism; D002531:Cerebellum / Q000187:drug effects / Q000196:embryology / Q000378:metabolism; D005314:Embryonic and Fetal Development / Q000187:drug effects*; D005260:Female; D005865:Gestational Age; D006168:Guinea Pigs; D007501:Iron / Q000378:metabolism / Q000494:pharmacology; D007774:Lactation; D008099:Liver / Q000187:drug effects / Q000196:embryology / Q000378:metabolism; D008274:Magnesium / Q000378:metabolism / Q000494:pharmacology; D008345:Manganese / Q000378:metabolism / Q000494:pharmacology; D011247:Pregnancy; D011897:Random Allocation; D013054:Spectrophotometry, Atomic; D013116:Spinal Cord / Q000187:drug effects / Q000196:embryology / Q000378:metabolism; D014018:Tissue Distribution; D014131:Trace Elements / Q000378:metabolism* / Q000494:pharmacology; D015032:Zinc / Q000378:metabolism / Q000494:pharmacology
chemical_list: D014131:Trace Elements; D008345:Manganese; D000535:Aluminum; D007501:Iron; D008274:Magnesium; D015032:Zinc; D002118:Calcium