title: [Mixed-type pancreatoblastoma. Report of a clinical case].
abstract: Pancreatoblastoma is a very rare tumor of the pancreas, affecting children in the first decade of life. Ultrasound and CT scan may be useful but pre-operative diagnosis is often quite difficult. High level of seric alpha-fetoprotein could be suggestive of pancreatoblastoma. The definitive diagnosis is however made by histologists when an organoid structure, well encapsulated, consisting of acinar cells with zymogen-like granules and squamoid corpuscle is demonstrated, sometimes associated with mesenchymal tissue (mixed-type pancreatoblastoma). Immunohistochemical studies may help in differentiating pancreatoblastoma from papillary cystic tumors, acinar cell carcinomas and endocrine pancreatic tumors of the pancreas. We report a case of mixed-type pancreatoblastoma in a 12-year-old female patient, located in the head of the pancreas. The treatment has been surgical, consisting of a duodeno-cephalo-pancreasectomy. Neither radiotherapy nor chemotherapy has been performed. The patient is alive, without recurrence, four months after the operation. Diagnostic, therapeutic and prognostic aspects are discussed.
authors.affiliation: Dipartimento di Chirurgia, Università degli Studi, Catania.
authors.forename: S
authors.initials: S
authors.lastname: Latteri
authors.forename: G
authors.initials: G
authors.lastname: Russo
authors.forename: R
authors.initials: R
authors.lastname: Vecchio
authors.forename: G
authors.initials: G
authors.lastname: Meli
authors.forename: F
authors.initials: F
authors.lastname: Latteri
mesh_terms: D002648:Child; D005260:Female; D006801:Humans; D010190:Pancreatic Neoplasms / Q000473:pathology*
vernacular_title: Pancreatoblastoma di tipo misto. Presentazione di un caso clinico.