title: Colposcopy as a tool for detection of human papillomavirus infection of uterine cervix in the setting of high prevalence of gynaecologic infections.
abstract: A cross sectional study involving 257 women from the Maternal and Child Health Centre (MCH) in Delhi was initiated for screening clinically, cytologically, colposcopically, and microbiologically for several gynaecologic infections. Eighty percent of the women had one or more gynaecologic infections and 31.1% had three or more infections. Cytology revealed changes suggestive of condyloma in 3 (1.2%) women only, while colposcopic examination suggested HPV changes in 117 (45.5%) women. A very high proportion of colposcopically detected lesions (78.6%) had evidence of HPV related changes in histology. The specificity of these lesions were further confirmed by Pan HPV DNA in-situ hybridisation, when 84% of the colposcopy is a valuable tool for detecting subclinical HPV lesions in a setting with high prevalence of gynaecologic infections.
authors.affiliation: Division of Clinical Research, Institute of Cytology and Preventive Oncology (ICMR), Maulana Azad Medical College Campus, Bahadur Shah Zafar Marg, New Delhi, India.
authors.forename: V
authors.initials: V
authors.lastname: Singh
authors.forename: A
authors.initials: A
authors.lastname: Parashari
authors.forename: P
authors.initials: P
authors.lastname: Sodhani
authors.forename: D
authors.initials: D
authors.lastname: Chattopadhya
authors.forename: L
authors.initials: L
authors.lastname: Satyanarayana
authors.forename: M M
authors.initials: MM
authors.lastname: Gupta
authors.forename: A
authors.initials: A
authors.lastname: Sehgal
mesh_terms: D003127:Colposcopy; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007194:India / Q000453:epidemiology; D027383:Papillomaviridae; D030361:Papillomavirus Infections / Q000175:diagnosis* / Q000453:epidemiology; D014412:Tumor Virus Infections / Q000175:diagnosis* / Q000453:epidemiology; D002577:Uterine Cervical Diseases / Q000175:diagnosis*