[In vitro studies of DNA synthesis inhibition by hyperthermia (42.5 degrees C, 120 min) and cytostatic drugs in embryonal tumors and sarcomas in childhood].
The effect of hyperthermia (HT), (42.5 degrees C, 120 min), cytostatic agents and the simultaneous application of HT and cytostatics on embryonal tumors and sarcomas in children was studied using an autoradiographic in vitro method. The 3H-thymidine and 3H-uridine incorporation inhibition was measured. HT inhibits DNA and RNA synthesis in a range of 42.0%-51.0% and 45.6%-58.3%. HT enhances the effect of the cytostatic agents ADM, CPM, cis-PL, BLM and BCNU highly significantly. In each case and without exception the simultaneous application of HT and cytostatics overcomes primary resistance to HT or the cytostatic concerned.
Willnow
U
U
Medizinische Einrichtungen, Heinrich-Heine Universität, Klinik für Kinderchirurgie, Düsseldorf.
Dumon
K
K
D000970:Antineoplastic Agents / Q000494:pharmacology*; D001345:Autoradiography; D002455:Cell Division / Q000187:drug effects*; D002470:Cell Survival / Q000187:drug effects; D002648:Child; D003131:Combined Modality Therapy; D004261:DNA Replication / Q000187:drug effects*; D019008:Drug Resistance, Neoplasm; D006801:Humans; D006979:Hyperthermia, Induced; D009373:Neoplasms, Germ Cell and Embryonal / Q000473:pathology*; D012509:Sarcoma / Q000473:pathology*; D014407:Tumor Cells, Cultured / Q000187:drug effects*; D014410:Tumor Stem Cell Assay
D000970:Antineoplastic Agents
In vitro-Untersuchungen der DNA-Synthesehemmung durch Hyperthermie (42.5 degrees C, 120 min) und Zytostatika bei embryonalen Tumoren und Sarkomen des Kindesalters.