title: [Use of fluoroquinolones in rheumatology].
abstract: The efficacy and tolerance of 3 fluoroquinolones (ciprofloxacin, pefloxacin, lomefloxacin) were studied in 157 patients with rheumatic diseases concurrent with infection-induced abnormalities. Infection cure was achieved in 123 (78.6%) patients, as evidenced by clinical, microbiological, and serological studies. The tolerance of fluoroquinolones was regarded as good, satisfactory, and poor in 114 (72.6%), 37 (23.6%), and 6 (3.8%) patients, respectively. All representative drugs of the fluoroquinolones series produced typical adverse reactions. The authors consider it expedient to make further clinical studies to test the optimal treatment regimens and to expand indications for the use of fluoroquinolones in this group of patients.
authors.forename: B S
authors.initials: BS
authors.lastname: Belov
authors.forename: S V
authors.initials: SV
authors.lastname: Shubin
authors.forename: V A
authors.initials: VA
authors.lastname: Nasonova
authors.forename: S I
authors.initials: SI
authors.lastname: Soldatova
authors.forename: G M
authors.initials: GM
authors.lastname: Tarasova
authors.forename: M M
authors.initials: MM
authors.lastname: Urumova
authors.forename: M A
authors.initials: MA
authors.lastname: Ushakova
authors.forename: L P
authors.initials: LP
authors.lastname: Anan'eva
mesh_terms: D000293:Adolescent; D000328:Adult; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002939:Ciprofloxacin / Q000008:administration & dosage / Q000627:therapeutic use*; D004361:Drug Tolerance; D005260:Female; D024841:Fluoroquinolones; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D015366:Pefloxacin / Q000008:administration & dosage / Q000627:therapeutic use*; D015363:Quinolones / Q000008:administration & dosage / Q000627:therapeutic use*; D012216:Rheumatic Diseases / Q000188:drug therapy*; D013997:Time Factors
chemical_list: D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D015363:Quinolones; D015366:Pefloxacin; D002939:Ciprofloxacin; C053091:lomefloxacin
vernacular_title: Primenenie ftorkhinolonov v revmatologii.