Complement activates neutrophils during PTCA procedure in patients with unstable angina pectoris.
We estimated adherence, aggregation and chemiluminescence of neutrophils as well as concentrations of C3c, C4 and C5 complement components and complement haemolytic activity (CH50) in 27 patients with unstable angina pectoris subjected to percutaneous transluminal coronary angioplasty (PTCA). The control group consisted of 12 patients with unstable angina pectoris, in whom coronary angiography was performed but PTCA was decided against for various reasons. Blood samples for examination were taken from coronary sinus and peripheral vein just before, 1 min and 20 min after PTCA or coronary angiography. We observed enhancement of neutrophil adherence, aggregation and chemiluminescence, and decrease in concentrations of C3c, C5 and complement haemolytic activity (CH50) after PTCA procedure. In conclusion we think that ischemia resulting from PTCA causes complement activation in an alternative pathway which seems to be connected with neutrophil activation.
Kowalski
J
J
First Department of Internal Medicine, Military School of Medicine, Lódź, Poland.
Kośmider
M
M
Pawlicki
L
L
Głowacka
E
E
Banasik
M
M
Baj
Z
Z
Ciećwierz
J
J
Paśnik
J
J
D000210:Acute-Phase Reaction / Q000175:diagnosis / Q000276:immunology; D000328:Adult; D000789:Angina, Unstable / Q000276:immunology / Q000628:therapy*; D015906:Angioplasty, Balloon, Coronary; D003167:Complement Activation / Q000276:immunology*; D015932:Complement C3c / Q000378:metabolism; D003182:Complement C5 / Q000378:metabolism; D015941:Complement Hemolytic Activity Assay; D003170:Complement Pathway, Alternative / Q000276:immunology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018375:Neutrophil Activation / Q000276:immunology; D009504:Neutrophils / Q000276:immunology*; D012016:Reference Values
D003182:Complement C5; D015932:Complement C3c