title: Chromosome analyses in a rhabdoid tumor of the brain.
abstract: A malignant rhabdoid tumor of the brain from a 19-month-old child was studied. Two related clones, 46,XX,-8,+der(8)t(8;22)(p11;q?12)x2,-22,del(22)(q12q?13) and 46,XX-8,+der(8)t(8;22) (p11;q?12) x2,-22,r(22) were found after chromosome analyses of primary and recurrent tumor, and multiple nude mouse passages of the tumor. Breakpoints were studied using FISH.
authors.affiliation: Department of Hematology/Oncology, Children's Hospital Medical Center, Cincinnati, Ohio 45229, USA.
authors.forename: K
authors.initials: K
authors.lastname: Klopfenstein
authors.forename: S
authors.initials: S
authors.lastname: Soukup
authors.forename: R
authors.initials: R
authors.lastname: Blough
authors.forename: C
authors.initials: C
authors.lastname: Mazewski
authors.forename: E
authors.initials: E
authors.lastname: Ballard
authors.forename: B
authors.initials: B
authors.lastname: Gotwals
authors.forename: B
authors.initials: B
authors.lastname: Lampkin
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000235:genetics*; D002872:Chromosome Deletion; D002892:Chromosomes, Human, Pair 22; D002898:Chromosomes, Human, Pair 8; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007223:Infant; D007621:Karyotyping; D051379:Mice; D008819:Mice, Nude; D018335:Rhabdoid Tumor / Q000235:genetics*; D014178:Translocation, Genetic