Genetic factors regulate processes related to anxiety in mice.
The propensity for anxiety-related behavior has been studied by comparing two highly inbred strains of mice, ABP/Le and C57BL/6ByJ, in two behavioral procedures, open-field and light-dark preference. Their Mendelian F2 population allowed us to evaluate the putative involvement of four easily identifiable loci in anxiogenic processes. In fact, chromosomal regions containing the brown, pink-eyed dilution and short-ear loci on the 4th, 7th and 9th chromosomes respectively are associated with anxiety-related behavior patterns. In addition, binding of [3H]flumazenil to brain GABA(A) receptors was measured as a biochemical index that may be associated with observed behavior patterns.
Clément
Y
Y
U.R.A. C.N.R.S. 1957, Groupe hospitalier Pitié-Salpêtrière, Paris, France.
Proeschel
M F
MF
Bondoux
D
D
Girard
F
F
Launay
J M
JM
Chapouthier
G
G
D000818:Animals; D001007:Anxiety / Q000235:genetics*; D001522:Behavior, Animal / Q000502:physiology; D001921:Brain / Q000378:metabolism; D002755:Choice Behavior; D002874:Chromosome Mapping; D003624:Darkness; D005442:Flumazenil / Q000378:metabolism; D018757:GABA Modulators / Q000378:metabolism; D008027:Light; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008815:Mice, Inbred Strains; D011963:Receptors, GABA-A / Q000378:metabolism
D018757:GABA Modulators; D011963:Receptors, GABA-A; D005442:Flumazenil