[Cushing syndrome disclosing bronchial neuroendocrine carcinoma: value of scintigraphy with octreotide].
A 44-year-old man presenting with atypical maniac behavior and hypokaliemia was diagnosed with Cushing's syndrome and treated in emergency by bilateral adrenalectomy. Endocrine investigations were suggestive of an ectopic adrenocorticotropic (ACTH) secretion, both at baseline (mean ACTH levels = 215 pg/mL, beta-lipotropic hormone = 2329 pg/mL; molar ratio > 5) and after pharmacodynamic testing (lack of inhibition of ACTH by dexamethasone, blunted ACTH response to corticotropin releasing hormone). Ectopic ACTH secretion was investigated while pituitary ACTH secretion was suppressed by dexamethasone. A paradoxical rise of ACTH from 384 to 717 pg/mL was observed after subcutaneous administration of 500 micrograms octreotide. A right lung tumor that remained occult for 7 years was only revealed by octreotide scintigraphy, despite annual chest tomodensitometric examinations. Right inferior lung lobectomy allowed allowed for removal of a 13 mm tumor corresponding to a bronchial neuroendocrine carcinoma with positive immunostaining for ACTH. Mediastinal lymph nodes were histologically normal. Perioperative ACTH measurements, showing a more than 50% decrease from baseline at 15 minutes after tumor resection, were suggestive of complete tumor removal. This was confirmed 10 days postoperatively by undetectable ACTH levels and by a negative octreotide scintigraphy after surgery. This case report of an occult ACTH secreting bronchial neuroendocrine carcinoma illustrates the diagnostic value of octreotide scintigraphy, and the prognostic value of perioperative ACTH measurements in such cases.
Vallette
S
S
Service de médecine interne, CHU de la Timone, Marseille, France.
Disdier
P
P
Morange-Ramos
I
I
Thomas
P A
PA
Azorin
J M
JM
Jaquet
P
P
Weiller
P J
PJ
Brue
T
T
D000182:ACTH Syndrome, Ectopic / Q000000981:diagnostic imaging; D000328:Adult; D001984:Bronchial Neoplasms / Q000150:complications* / Q000000981:diagnostic imaging / Q000378:metabolism; D018278:Carcinoma, Neuroendocrine / Q000150:complications* / Q000000981:diagnostic imaging / Q000378:metabolism; D003480:Cushing Syndrome / Q000209:etiology*; D006728:Hormones; D006801:Humans; D008297:Male; D015282:Octreotide; D011877:Radionuclide Imaging
D006728:Hormones; D015282:Octreotide
Syndrome de Cushing révélateur d'un carcinome neuroendocrine bronchique: intérêt de la scintigraphie à l'octréotide.