title: The mitochondrial genome of the mosquito Anopheles gambiae: DNA sequence, genome organization, and comparisons with mitochondrial sequences of other insects.
abstract: The entire 15,363 bp mitochondrial genome was cloned and sequenced from the mosquito Anopheles gambiae. With respect to the protein-coding genes, rRNA genes and the control region, the gene order was identical to that reported for other insects. There were significant differences, however, in the position and orientation of specific tRNA loci. The overall nucleotide composition was heavily biased towards adenine and thymine, which accounted for 77.6% of all nucleotides. Comparisons were made with the mitochondrial genomes of other insects on the basis genome size and organization, DNA and putative amino acid sequence data, nucleotide substitutions, codon usage and bias, and patterns of AT enrichment.
authors.affiliation: Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, Atlanta, GA 30314-3724, USA.
authors.forename: C B
authors.initials: CB
authors.lastname: Beard
authors.forename: D M
authors.initials: DM
authors.lastname: Hamm
authors.forename: F H
authors.initials: FH
authors.lastname: Collins
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000852:Anopheles / Q000145:classification / Q000235:genetics*; D001482:Base Composition; D001483:Base Sequence; D003062:Codon; D018076:DNA, Complementary; D004272:DNA, Mitochondrial / Q000235:genetics*; D017344:Genes, Insect; D016678:Genome; D008969:Molecular Sequence Data; D009690:Nucleic Acid Conformation; D010802:Phylogeny; D012335:RNA, Ribosomal / Q000235:genetics; D012343:RNA, Transfer
chemical_list: D003062:Codon; D018076:DNA, Complementary; D004272:DNA, Mitochondrial; D012335:RNA, Ribosomal; D012343:RNA, Transfer