Peroxynitrite inhibits glutathione S-conjugate transport.
Peroxynitrite was demonstrated to inhibit the active efflux of glutathione S-conjugates (2,4-dinitrophenyl-S-glutathione and bimane-S-glutathione) from human erythrocytes and the erythrocyte membrane ATPase activity stimulated by glutathione S-conjugates. As the multidrug resistance-associated protein (MRP) is responsible for the transport of glutathione S-conjugates in mammalian cells, these results point to the possibility of the effect of peroxynitrite on the MRP function.
Soszyński
M
M
Department of Molecular Biophysics, University of Lódź, Poland. sosmirek@krysia.uni.lodz.pl
Bartosz
G
G
D001692:Biological Transport / Q000187:drug effects; D001643:Bridged Bicyclo Compounds / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004912:Erythrocytes / Q000378:metabolism*; D005978:Glutathione / Q000031:analogs & derivatives* / Q000378:metabolism; D006801:Humans; D009566:Nitrates / Q000494:pharmacology*
D001643:Bridged Bicyclo Compounds; D009566:Nitrates; C080120:glutathione-bimane; C030190:S-(2,4-dinitrophenyl)glutathione; C039642:peroxynitric acid; D005978:Glutathione