[Positive seroconversion syphilis in a patient with acute lymphocytic leukemia after allogeneic bone marrow transplantation].
An acute lymphocytic leukemia patient underwent allogeneic bone marrow transplantation (BMT) from a sibling who was serologically positive for syphilis. After the donor was administered antibiotic therapy, the titration of treponema pallidum hemagglutination (TPHA) decreased from x1260 to x320. Thereafter, the graft consisting of mononuclear cells was transplanted. TPHA of the recipient turned positive on day +63, but became negative 1.5 years after BMT. Although the cause of the seroconversion of TPHA seemed to be the contamination of treponema to the graft, the adoptive transfer could not be ruled out as an another possible cause.
Naohara
T
T
Department of Internal Medicine,Sapporo Hokuyu Hospital.
Suzuki
G
G
Masauzi
N
N
Ohizumi
H
H
Kobayashi
N
N
Ogasawara
M
M
Kiyama
Y
Y
Saitoh
M
M
Higa
Y
Y
Kasai
M
M
D000328:Adult; D000658:Amoxicillin / Q000031:analogs & derivatives / Q000627:therapeutic use; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D006801:Humans; D016867:Immunocompromised Host; D008297:Male; D010406:Penicillins / Q000627:therapeutic use; D010878:Piperacillin / Q000627:therapeutic use; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000628:therapy*; D013587:Syphilis / Q000175:diagnosis / Q000188:drug therapy / Q000635:transmission*; D013588:Syphilis Serodiagnosis; D014184:Transplantation, Homologous
D010406:Penicillins; C037485:aspoxicillin; D000658:Amoxicillin; D010878:Piperacillin