[Effect of saponins from Hedera taurica Carr. and modified muramylpeptides on replication of human immunodeficiency virus in vitro].
The effects of muramyldipeptide (MDP), several new MDP derivatives, and saponins derived from Hedera taurica Carr, on the in vitro replication of HIV-1 were studied. The coefficient of alteration of the rate of HIV replication was used to compare these reagents' effects on virus replication in Jurkat-tat cells. This coefficient was calculated as the ratio of concentrations of HIV p24 in supernatants to the amount of viable cells. Muramylpeptides boosted HIV replication. Only one modified muramylpeptide alpha-butyl-MDP and tauroside H2 were not capable of boosting HIV-1 antigen production.
Krivorutchenko
Iu L
IuL
Andronovskaia
I B
IB
Chirva
V Ia
VIa
Pertel'
S S
SS
Grishkovets
V I
VI
Zemliakov
A E
AE
Kur'ianov
V O
VO
Krivoshein
Iu S
IuS
D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000494:pharmacology*; D003470:Culture Media; D016655:HIV Core Protein p24 / Q000032:analysis; D015497:HIV-1 / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D019169:Jurkat Cells; D010944:Plants / Q000737:chemistry*; D012503:Saponins / Q000494:pharmacology*; D014779:Virus Replication / Q000187:drug effects*
D003470:Culture Media; D016655:HIV Core Protein p24; D012503:Saponins; D000119:Acetylmuramyl-Alanyl-Isoglutamine
Vliianie saponinov iz Hedera taurica Carr. i modifitsirovannykh muramilpeptidov na reproduktsiiu virusa immunodefitsita cheloveka in vitro.