title: High resolution imaging of native biological sample surfaces using scanning probe microscopy.
abstract: The possibility of acquiring high resolution topographs using scanning probe microscopes under physiological conditions allows the observation of biomolecules at work. Progress has recently been made in imaging protein-DNA complexes, individual oligomers and protein arrays. Scanning probe microscopes are now tools that complement X-ray crystallography and electron microscopy.
authors.affiliation: ME Müller Institute for Structural Biology, Biozentrum, Klingelbergstr 70, CH-4056, Basel, Switzerland. aengel@ubaclu.unibas.ch
authors.forename: A
authors.initials: A
authors.lastname: Engel
authors.forename: C A
authors.initials: CA
authors.lastname: Schoenenberger
authors.forename: D J
authors.initials: DJ
authors.lastname: Müller
mesh_terms: D001425:Bacterial Outer Membrane Proteins / Q000648:ultrastructure; D018360:Crystallography, X-Ray; D004247:DNA / Q000648:ultrastructure*; D004268:DNA-Binding Proteins / Q000648:ultrastructure*; D046911:Macromolecular Substances; D008853:Microscopy / Q000295:instrumentation / Q000379:methods*; D008854:Microscopy, Electron; D010957:Plasmids; D011487:Protein Conformation; D013499:Surface Properties
chemical_list: D001425:Bacterial Outer Membrane Proteins; D004268:DNA-Binding Proteins; D046911:Macromolecular Substances; D004247:DNA