Respiratory and electrocortical responses to acoustic stimulation.
Although sleep-related obstructive apnea is most often associated with transient arousal, the impact of this arousal on respiratory control remains unclear. We employed binaural tone bursts (.5 second duration) to elicit repetitive transient arousals from sleep during polygraphic recordings in 5 adult volunteers. By this method, we elicited repetitive transient arousals with a mean duration of approximately 10 seconds from all stages of sleep. With respect to the 3 pre-stimulus breaths, acoustic stimulation was associated with increased tidal volume and decreased inspiratory duration for at least 4 breaths. These respiratory responses to acoustic stimulation were not significantly influenced by either presence of transient arousal from sleep or the sleep state from which arousal occurred. We conclude that transient electro-cortical state changes may be repeatedly evoked from all sleep stages by transient acoustic stimulation in normal sleepers. This sensory stimulation represents a significant respiratory stimulus even when generalized arousal from sleep does not occur.
Carley
D W
DW
Department of Medicine, University of Illinois College of Medicine at Chicago, Chicago 60612, USA.
Applebaum
R
R
Basner
R C
RC
Onal
E
E
Lopata
M
M
D000161:Acoustic Stimulation; D000328:Adult; D001143:Arousal; D004558:Electric Stimulation; D004569:Electroencephalography; D004576:Electromyography; D005260:Female; D006801:Humans; D008297:Male; D012123:Pulmonary Ventilation; D012891:Sleep Apnea Syndromes; D012895:Sleep, REM; D013997:Time Factors