Modulation of cranial bone healing with a heparin-like dextran derivative.
Substituted dextran polymers have been shown to bind growth factors and protect them from enzymatic degradation. Using this information, other researchers have been able to use these substituted dextrans to enhance the healing of bone in an environment where bone would otherwise not regenerate. We used substituted dextran polymers to evaluate their ability to accelerate the healing of cranial bone in a rabbit model. We were able to document a more rapid rate of healing and demonstrate micrographic evidence to support that conclusion. Possible mechanisms are postulated.
Albo
D
D
Department of Surgery, Medical College of Pennsylvania and Hahnemann University, Philadelphia 19129, USA.
Long
C
C
Jhala
N
N
Atkinson
B
B
Granick
M S
MS
Wang
T
T
Meddahi
A
A
Barritault
D
D
Solomon
M P
MP
D000704:Analysis of Variance; D000818:Animals; D001672:Biocompatible Materials / Q000494:pharmacology; D001861:Bone Regeneration / Q000187:drug effects* / Q000502:physiology; D003911:Dextrans / Q000494:pharmacology*; D006493:Heparin / Q000502:physiology; D006801:Humans; D011817:Rabbits; D016037:Single-Blind Method; D012886:Skull; D018709:Statistics, Nonparametric; D014945:Wound Healing / Q000187:drug effects*
D001672:Biocompatible Materials; D003911:Dextrans; C099253:CMDBS 25; D006493:Heparin