[Antistreptococcal immunity in rheumatism and urban ecological risk factors].
143 rheumatic patients and 40 healthy subjects exposed to different air pollution have been studied. In three representative groups the following parameters were studied: immunocompetent cell function (by leukocyte migration inhibition with streptococcal antigen), humoral response (by antibodies to streptococcus A polysaccharide shown at immunodiffusion), titres of antistreptolysin 0 (ASL0) and antistreptohyaluronidase (ASH). High hypersensitivity of delayed type was registered in patients from clean zones. In those breathing with polluted air there were elevated levels of antibodies to A-polysaccharide. ASL0 and ASH, their high titer in summer evidencing toxic influence of photo-oxidants. Based on the data obtained it is possible to predict the risk of greater rheumatism activity in zone with greater air pollution.
Amanzholova
Sh A
ShA
D000328:Adult; D000393:Air Pollutants / Q000009:adverse effects; D000917:Antibody Formation; D000989:Antistreptolysin / Q000097:blood; D004463:Ecology; D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D008297:Male; D008875:Middle Aged; D012216:Rheumatic Diseases / Q000276:immunology*; D012307:Risk Factors; D013297:Streptococcus pyogenes / Q000276:immunology*; D014505:Urban Population
D000393:Air Pollutants; D000989:Antistreptolysin; C019708:antistreptohyaluronidase
Protivostreptokokkovyĭ immunitet pri revmatizme i urboékologicheskie faktory riska.