title: Hepatic transplantation in children under 3 months of age: a single centre's experience.
abstract: Liver transplantation in neonates represents a major medical and technical challenge particularly in babies weighing less than 5 kg. The authors report the experience of 10 liver transplants in 9 babies (6 boys and 3 girls), mean age, 6 weeks (range, 2 to 11); median weight, 3.7 kg (range, 2.4 to 5). All had fulminant hepatic failure caused by neonatal haemochromatosis (n = 3), non-A non-B hepatitis (n = 3), total parenteral nutrition induced (n = 1), hepatitis B (n = 1), and hepatic haemangio-endothelioma (n = 1). One child underwent retransplantation for hepatic artery thrombosis. Immunosuppression was by Cyclosporine A-based triple therapy in all cases. All received a reduced size graft consisting of left lobe (n = 1), left lateral segment (n = 6) and monosegment III (n = 3). In nine cases the donor hepatic artery was anastomosed to an iliac artery conduit from the infrarenal aorta, and a Roux loop was used for bile duct reconstruction. Primary abdominal wound closure was possible in six patients, skin closure alone in one, and a silastic patch was used in three. Complications included infection (n = 5), bowel perforation (n = 2), diaphragmatic perforation (n = 2), bile leak (n = 1), hepatic artery thrombosis (n = 1), and portal vein thrombosis (n = 1). None of the babies experienced acute rejection. Currently five of the nine recipients are alive with good graft function at a mean follow-up of 22 months (range, 5 to 58). Of the four deaths, two were related to infection (one in combination with portal vein thrombosis), one to multiorgan failure and fluid overload, and one to early graft dysfunction and sepsis after undergoing retransplantation for hepatic artery thrombosis. From our experience liver transplantation offers a promising option for the treatment of severe liver disease in children less than 3 months old.
authors.affiliation: Liver Transplant Surgical Service, King's College Hospital, London, England.
authors.forename: H
authors.initials: H
authors.lastname: Bonatti
authors.forename: P
authors.initials: P
authors.lastname: Muiesan
authors.forename: S
authors.initials: S
authors.lastname: Connelly
authors.forename: A
authors.initials: A
authors.lastname: Baker
authors.forename: G
authors.initials: G
authors.lastname: Mieli-Vergani
authors.forename: P
authors.initials: P
authors.lastname: Gibbs
authors.forename: N
authors.initials: N
authors.lastname: Heaton
authors.forename: M
authors.initials: M
authors.lastname: Rela
mesh_terms: D000367:Age Factors; D019072:Antibiotic Prophylaxis; D016572:Cyclosporine / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007223:Infant; D007231:Infant, Newborn; D017093:Liver Failure / Q000601:surgery*; D016031:Liver Transplantation / Q000379:methods; D008297:Male; D008485:Medical Audit; D011183:Postoperative Complications; D012189:Retrospective Studies
chemical_list: D007166:Immunosuppressive Agents; D016572:Cyclosporine