Immunoprophylaxis of group B respiratory syncytial virus infection in cotton rats.
Two antigenic groups of respiratory syncytial virus (RSV) have been identified: A (RSV/A) and B (RSV/B). Topical administration of human IgG screened for high titers of antibody to RSV/A (RSVIg) is protective against RSV/A infection in the cotton rat model. The study attempted to determine if topical RSVIg would also be protective against RSV/B. Cotton rats were pretreated intranasally with RSVIg or with monospecific antiserum obtained from animals previously infected with RSV/A or RSV/B (day 0), challenged intranasally with RSV/A or RSV/B (day 1), and sacrificed for virus titration (day 5). Cotton rat antiserum to RSV/B protected against RSV/A and RSV/B, while antiserum to RSV/A protected only against RSV/A. RSVIg, although prepared on the basis of activity against RSV/A, was also protective against RSV/B.
Faverio
L A
LA
Department of Pediatrics, George Washington University School of Medicine and Health Sciences, Washington, DC, USA.
Piazza
F M
FM
Johnson
S A
SA
Darnell
M E
ME
Ottolini
M G
MG
Hemming
V G
VG
Prince
G A
GA
D000818:Animals; D006801:Humans; D007106:Immune Sera / Q000276:immunology; D007074:Immunoglobulin G / Q000276:immunology; D018357:Respiratory Syncytial Virus Infections / Q000517:prevention & control*; D012136:Respiratory Syncytial Viruses / Q000276:immunology*; D016205:Sigmodontinae
D007106:Immune Sera; D007074:Immunoglobulin G