Heliquinomycin, a new inhibitor of DNA helicase, produced by Streptomyces sp. MJ929-SF2 II. Structure determination of heliquinomycin.
The structure of heliquinomycin which was isolated from the culture broth of Streptomyces sp. MJ929-SF2 was studied by NMR spectroscopies, X-ray crystallographic analysis and degradation experiments. Heliquinomycin is the first member of glycosylated rubromycins and griseorhodins group antibiotics.
Chino
M
M
Institute of Microbial Chemistry, Tokyo, Japan.
Nishikawa
K
K
Tsuchida
T
T
Sawa
R
R
Nakamura
H
H
Nakamura
K T
KT
Muraoka
Y
Y
Ikeda
D
D
Naganawa
H
H
Sawa
T
T
Takeuchi
T
T
D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D016227:Benzoquinones / Q000737:chemistry / Q000494:pharmacology; D018360:Crystallography, X-Ray; D004265:DNA Helicases / Q000037:antagonists & inhibitors*; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D008968:Molecular Conformation; D015394:Molecular Structure; D013141:Spiro Compounds / Q000737:chemistry / Q000494:pharmacology; D013237:Stereoisomerism; D013302:Streptomyces / Q000737:chemistry*
D000900:Anti-Bacterial Agents; D016227:Benzoquinones; D004791:Enzyme Inhibitors; D013141:Spiro Compounds; C101772:heliquinomycin; D004265:DNA Helicases