Very long-chain fatty acid pattern in crush syndrome patients in the Kobe earthquake.
Profiles of very long-chain fatty acid were studied in the erythrocyte membrane of healthy controls and four patients with crush syndrome caused by the Great-Hanshin Earthquake. The identities of cis-17-hexacosenoic acid (C26:1) and hexacosanoic acid (C26:0) were verified by gas chromatography-mass spectrometry (GC-MS). The ratios C26:1/C22:0, C26:0/C22:0, C24:1/C22:0, and C20:1/C22:0 also were elevated. These findings suggest that active oxygen species and/or free radicals generated by ischemia-reperfusion in the crush syndrome result in beta-oxidation disorders in peroxisomes.
Miwa
A
A
Department of Legal Medicine, Kobe University School of Medicine, Japan.
Adachi
J
J
Mizuno
K
K
Tatsuno
Y
Y
D000328:Adult; D000368:Aged; D003444:Crush Syndrome / Q000097:blood*; D004190:Disasters; D004910:Erythrocyte Membrane / Q000737:chemistry; D005227:Fatty Acids / Q000097:blood* / Q000737:chemistry; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged
D005227:Fatty Acids; C017364:hexacosanoic acid