title: Proliferative response of human and animal tumours to surgical wounding of normal tissues: onset, duration and inhibition.
abstract: Acceleration of secondary tumour growth and metastases following excision of a primary tumour has been attributed to the consequent removal of primary tumour-generated inhibitory factors. However, our studies have shown that surgical wounding of normal tissues significantly stimulated the growth of malignant tissues without the concomitant presence or excision of a tumour mass. A humoral stimulating component was indicated by the proliferative response of tumours and metastases distant from the surgical wound. All 16 human and murine tumours, of nine different histologies, showed a measurable acceleration of growth when implanted in surgically treated animals, suggesting that the ability of malignant tissue to respond to surgical wounding of normal tissue was not histologically or species specific. The proliferative surge of malignant tissues was detectable soon after wounding and had a duration of 2-3 days. The surgical wound as the source of the tumour-stimulating factor(s) was affirmed by the significant inhibition of tumour proliferative responses when a somatostatin analogue was applied topically to the surgical wound within 1 h of wounding, and/or during the critical tumour-stimulatory period of 1-2 days after wounding. A potential therapeutic window for reducing a risk factor that may be inadvertently imposed upon every surgical/oncology patient is indicated.
authors.affiliation: Biomeasure Inc., Milford, MA 01757-3650, USA.
authors.forename: A E
authors.initials: AE
authors.lastname: Bogden
authors.forename: J P
authors.initials: JP
authors.lastname: Moreau
authors.forename: P A
authors.initials: PA
authors.lastname: Eden
mesh_terms: D000818:Animals; D002455:Cell Division; D006801:Humans; D008175:Lung Neoplasms / Q000556:secondary; D051379:Mice; D008819:Mice, Nude; D009362:Neoplasm Metastasis; D009368:Neoplasm Transplantation; D010456:Peptides, Cyclic / Q000494:pharmacology; D013004:Somatostatin / Q000031:analogs & derivatives / Q000494:pharmacology; D013312:Stress, Physiological / Q000503:physiopathology; D013514:Surgical Procedures, Operative; D013997:Time Factors; D014407:Tumor Cells, Cultured; D014945:Wound Healing
chemical_list: D010456:Peptides, Cyclic; C060347:lanreotide; D013004:Somatostatin