[Preoperative localization of parathyroid lesions with Tc-99m-MIBI/iodine 123].
OBJECTIVE
Assess the sensitivity of MIBI-Tc for the detection of parathyroid lesions and define the threshold of detection by evaluating contrast uptake at 20 minutes and 2 hours.


METHODS
Fifty-five operated and cured patients were studied. Image acquisitions were made 20 minutes and 2 hours after injection of 555 MBq MIBI-Tc then 2 hours after injection of 5.55 MBq iodine 123.


RESULTS
A total of 87 pathological glands were found including 47 adenomas (80 to 8820 mg) and 40 hyperplasias (44 to 2175 mg). Detection sensitivity was 81% for adenomas and 30% for hyperplasia, but the cell type did not appear to be a determining factor.


CONCLUSIONS
Scintigraphic visualization of parathyroid lesions is more frequent when there is a single lesion. At least one lesion was seen in 80% of the patients. The threshold of detection was 225 mg. Enhancement of parathyroid uptake with MIBI-Tc compared with the thyroid between 20 minutes and 2 hours was not a constant and of unknown origin.
Huglo
D
D
Institut de Médecine nucléaire et Imagerie fonctionnelle, Centre Hospitalier Régional et Universitaire de Lille.
Nocaudie
M
M
Lecomte-Houcke
M
M
Ziegels
P
P
Bailliez
A
A
Carnaille
B
B
Proye
C
C
Marchandise
X
X
D000236:Adenoma / Q000000981:diagnostic imaging; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D006961:Hyperparathyroidism / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D006965:Hyperplasia; D007457:Iodine Radioisotopes; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D010280:Parathyroid Glands / Q000000981:diagnostic imaging / Q000473:pathology / Q000648:ultrastructure; D011877:Radionuclide Imaging; D012680:Sensitivity and Specificity; D017256:Technetium Tc 99m Sestamibi
D007457:Iodine Radioisotopes; D017256:Technetium Tc 99m Sestamibi
Localisation préopératoire des lésions parathyroïdiennes par la scintigraphie 99mTc MIBI/iode 123.