title: Proton MR spectroscopy in Pelizaeus-Merzbacher disease.
abstract: Proton MR spectroscopic findings in two patients with genetically defined Pelizaeus-Merzbacher disease revealed ratios of N-acetylaspartate/creatine and choline-containing compounds/creatine that were not significantly different from those found in a population of healthy subjects. These findings suggest that proton MR spectroscopy can aid in the diagnosis of Pelizaeus-Merzbacher disease.
authors.affiliation: Department of Pediatrics, Faculty of Medicine, University of Chiba, Japan.
authors.forename: J
authors.initials: J
authors.lastname: Takanashi
authors.forename: K
authors.initials: K
authors.lastname: Sugita
authors.forename: H
authors.initials: H
authors.lastname: Osaka
authors.forename: M
authors.initials: M
authors.lastname: Ishii
authors.forename: H
authors.initials: H
authors.lastname: Niimi
mesh_terms: D000293:Adolescent; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D002794:Choline / Q000378:metabolism; D003401:Creatine / Q000378:metabolism; D002549:Diffuse Cerebral Sclerosis of Schilder / Q000175:diagnosis* / Q000235:genetics / Q000503:physiopathology; D004734:Energy Metabolism / Q000502:physiology*; D005091:Exons; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D017354:Point Mutation / Q000235:genetics; D012016:Reference Values
chemical_list: D001224:Aspartic Acid; C000179:N-acetylaspartate; D003401:Creatine; D002794:Choline