title: Gentamicin retinal toxicity after cataract surgery in an eye that underwent vitrectomy.
abstract: A cataract developed in a 23-year-old man 4 months after a vitrectomy to repair a traumatic retinal detachment. An uneventful phacoemulsification was performed, using antibiotic-fortified infusion solution. Afterward, a large area of atrophic retina, consistent with gentamicin toxicity, was observed in the macula. The patient remains stable with 20/200 best-corrected acuity. The authors suggest that because the vitreous had been removed, gentamicin was able to settle over the macula during the entire cataract procedure. Therefore, gentamicin should be used intracamerally with caution, especially in eyes in which vitrectomy has been performed.
authors.affiliation: Mt. Sinai School of Medicine, New York, NY, USA.
authors.forename: J D
authors.initials: JD
authors.lastname: Rosenbaum
authors.forename: D M
authors.initials: DM
authors.lastname: Krumholz
authors.forename: D M
authors.initials: DM
authors.lastname: Metz
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D002386:Cataract / Q000209:etiology; D005131:Eye Injuries / Q000601:surgery; D005451:Fluorescein Angiography; D005500:Follow-Up Studies; D005654:Fundus Oculi; D005839:Gentamicins / Q000009:adverse effects*; D006801:Humans; D008297:Male; D018918:Phacoemulsification; D012160:Retina / Q000187:drug effects* / Q000293:injuries / Q000601:surgery; D012163:Retinal Detachment / Q000209:etiology / Q000601:surgery; D012164:Retinal Diseases / Q000139:chemically induced*; D014821:Vitrectomy / Q000009:adverse effects*; D014949:Wounds, Nonpenetrating / Q000601:surgery
chemical_list: D000900:Anti-Bacterial Agents; D005839:Gentamicins