Pharmacokinetics and bronchial diffusion of single daily dose amikacin in cystic fibrosis patients.
A single daily dose of amikacin 35 mg/kg by i.v. infusion over 30 min in 18 cystic fibrosis patients achieved mean serum peak and trough concentrations of 121.4 mg/L (+/- 37.3) and 0.88 mg/L (+/- 0.62), respectively. Pharmacokinetic parameters and bronchial diffusion of amikacin showed marked inter-patient variability. The highest concentrations in sputum were obtained at 2 h (10.95 +/- 7.55 mg/L) and decreased slowly to reach a mean concentration of 2.14 mg/L (range 0.2-3.8 mg/L) just before the following infusion. An increase in the body clearance of amikacin and a decrease in the volume of distribution according to age were observed.
Canis
F
F
Laboratoire de Bactériologie-Hygiène, Centre Hospitalier Régional et Universitaire, Lille, France.
Husson
M O
MO
Turck
D
D
Vic
P
P
Launay
V
V
Ategbo
S
S
Vincent
A
A
Courcol
R J
RJ
D000293:Adolescent; D000328:Adult; D000583:Amikacin / Q000008:administration & dosage / Q000032:analysis / Q000097:blood / Q000493:pharmacokinetics*; D001980:Bronchi / Q000737:chemistry / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D003550:Cystic Fibrosis / Q000097:blood / Q000378:metabolism*; D004058:Diffusion; D005260:Female; D016231:Fluorescence Polarization Immunoassay; D006207:Half-Life; D006801:Humans; D007223:Infant; D007262:Infusions, Intravenous; D008297:Male; D013183:Sputum / Q000737:chemistry
D000583:Amikacin