A hepatic graft tuberculosis transmitted from a living-related donor.
Exclusion of occult diseases in the donor organ and prevention of infectious disease transmission are minimal requirements in organ transplantation. We report here a case of hepatic graft tuberculosis, which was most likely transmitted by the graft from the living-related donor. The course of the recipient included tuberculosis, rejection, and other infections, which led to vanishing bile duct syndrome. Due to various infections and tuberculosis, as well as a strong interaction between rifampicin and tacrolimus, the patient died of pneumonia on day 273 after transplantation. This case emphasizes the importance of care in the selection of a living-related donor for liver transplantation.
Kiuchi
T
T
Department of Transplant Surgery, Kyoto University Faculty of Medicine, Japan.
Inomata
Y
Y
Uemoto
S
S
Satomura
K
K
Egawa
H
H
Okajima
H
H
Yamaoka
Y
Y
Tanaka
K
K
D000328:Adult; D004347:Drug Interactions; D017809:Fatal Outcome; D005260:Female; D005500:Follow-Up Studies; D006084:Graft Rejection; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000627:therapeutic use; D007223:Infant; D008107:Liver Diseases; D008111:Liver Function Tests; D016031:Liver Transplantation / Q000502:physiology; D019520:Living Donors; D009035:Mothers; D011183:Postoperative Complications; D012293:Rifampin / Q000009:adverse effects / Q000627:therapeutic use; D016559:Tacrolimus / Q000009:adverse effects / Q000627:therapeutic use; D014376:Tuberculosis / Q000635:transmission*
D007166:Immunosuppressive Agents; D012293:Rifampin; D016559:Tacrolimus