title: Derivative Y chromosome resulting from a t(Y;15) (q12;q11.2) in a boy with Prader-Willi syndrome.
abstract: Chromosome analysis of peripheral lymphocytes from a boy with Prader-Willi syndrome showed the presence of 45 chromosomes, including der(Y) resulting from a t(Y;15) (q12;q11.2). In situ hybridization using DYZ3 and D15S11 showed a positive signal and negative signal in derivative Y chromosome, respectively. The deficiency of 15pter q11.2 may not influence the clinical manifestation of Prader-Willi syndrome.
authors.affiliation: Department of Urology, Yamagata University, School of Medicine, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Suzuki
authors.forename: I
authors.initials: I
authors.lastname: Sasagawa
authors.forename: T
authors.initials: T
authors.lastname: Sawamura
authors.forename: M
authors.initials: M
authors.lastname: Ishigooka
authors.forename: H
authors.initials: H
authors.lastname: Kaneko
authors.forename: Y
authors.initials: Y
authors.lastname: Kubota
authors.forename: T
authors.initials: T
authors.lastname: Nakada
mesh_terms: D002675:Child, Preschool; D002884:Chromosomes, Human, Pair 15 / Q000235:genetics*; D006801:Humans; D007006:Hypogonadism / Q000175:diagnosis / Q000235:genetics*; D017403:In Situ Hybridization; D007621:Karyotyping; D008214:Lymphocytes / Q000737:chemistry; D008297:Male; D011218:Prader-Willi Syndrome / Q000175:diagnosis / Q000235:genetics*; D014178:Translocation, Genetic; D014998:Y Chromosome / Q000235:genetics*