title: [Are ISS and PTS unsuitable trauma scores for prediction of (possible) post-traumatic lung failure?].
abstract: Prostanoids are inflammatory mediators which originate from endothelial cells following local tissue damage. That is why plasma levels of prostanoids are possible markers of inflammatory response and severity of trauma. We were able to demonstrate that the systemic release of prostanoids does not depend on the score values (ISS, PTS) but rather on different trauma patterns (chest trauma, head injury). Influencing vascular permeability and resistance elevated plasma levels of prostanoids may explain the impairment of pulmonary function in traumatized patients. It seems to be useful to re-evaluate the scoring systems with respect to chest trauma and head injury.
authors.affiliation: Abteilung für Unfallchirurgie, Hand- und Wiederherstellungschirurgie, Universität Ulm.
authors.forename: F
authors.initials: F
authors.lastname: Gebhard
authors.forename: M
authors.initials: M
authors.lastname: Rösch
authors.forename: W
authors.initials: W
authors.lastname: Strecker
authors.forename: L
authors.initials: L
authors.lastname: Kinzl
authors.forename: U B
authors.initials: UB
authors.lastname: Brückner
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D003422:Critical Care; D005260:Female; D006801:Humans; D015601:Injury Severity Score; D008297:Male; D008875:Middle Aged; D009104:Multiple Trauma / Q000145:classification / Q000401:mortality* / Q000628:therapy; D011237:Predictive Value of Tests; D011379:Prognosis; D011453:Prostaglandins / Q000097:blood; D012128:Respiratory Distress Syndrome / Q000145:classification / Q000401:mortality* / Q000628:therapy; D012131:Respiratory Insufficiency / Q000145:classification / Q000401:mortality* / Q000628:therapy; D018746:Systemic Inflammatory Response Syndrome / Q000145:classification / Q000401:mortality / Q000628:therapy; D015599:Trauma Severity Indices
chemical_list: D011453:Prostaglandins
vernacular_title: Sind ISS und PTS untaugliche Trauma Scores zur Vorhersage eines (möglichen) posttraumatischen Lungenversagens?