Cytokine pattern in the cerebrospinal fluid from patients with GBS and CIDP.
Macrophage-colony stimulating factor (M-CSF) and, less frequently, IL-1 beta and IL-6 were detected in the cerebrospinal fluid (SF) from Guillain-Barré syndrome (GBS) patients. IL-1 alpha, IL-2, IL-10, TNF alpha, and IFN gamma were not found. Detectable cytokine levels were not observed in chronic inflammatory demyelinating polyneuropathy (CIDP) SF nor in any of the sera studied. These findings suggest a prominent intrathecal activation of cells of the monocyte/macrophage lineage (Mø) in GBS, and further support the hypothesis of a crucial role for Mø in GBS immunopathology.
Sivieri
S
S
Department of Neurological Sciences, University of Padua, Padova, Italy.
Ferrarini
A M
AM
Lolli
F
F
Matà
S
S
Pinto
F
F
Tavolato
B
B
Gallo
P
P
D016207:Cytokines / Q000134:cerebrospinal fluid*; D003711:Demyelinating Diseases / Q000134:cerebrospinal fluid*; D006801:Humans; D011129:Polyradiculoneuropathy / Q000134:cerebrospinal fluid*
D016207:Cytokines