title: [Stability of rifampicin in eyedrops].
abstract: The best composition of rifampicin eye-drops for extemporaneous preparation in pharmacies was developed by the authors. The stability of the eye-drops has been studied and storage condition and shelf-life were determined. The preparation, may be stored at minus 12 degrees C for one month and may be subsequently used when stored between 2 and 8 degrees C after the first opening for five days. Rifampicin and its degradation products have been separated by TLC using silicagel layer and chloroform-methanol (42 : 58) eluent. After separation of rifampicin and its degradation products their quantity have been determined by densitometry at 475 wavelength (540 nm for rifampicin quinone). This rifampicin eye-drops have been recommended for inclusion into the 7th Edition of the Official Model Prescriptions (Formulae Normales).
authors.affiliation: Országos Gyógyszerészeti Intézet, Budapest.
authors.forename: K
authors.initials: K
authors.lastname: Izer
authors.forename: I
authors.initials: I
authors.lastname: Török
authors.forename: G
authors.initials: G
authors.lastname: Magyarné Pintér
authors.forename: L E
authors.initials: LE
authors.lastname: Varsányi
authors.forename: J
authors.initials: J
authors.lastname: Lipták
mesh_terms: D002855:Chromatography, Thin Layer; D004355:Drug Stability; D015394:Molecular Structure; D009883:Ophthalmic Solutions; D012293:Rifampin / Q000031:analogs & derivatives / Q000302:isolation & purification
chemical_list: D009883:Ophthalmic Solutions; D012293:Rifampin
vernacular_title: Rifampicin tartalmú szemcseppek stabilitásának vizsgálata.