title: Two mosaic-YY males carrying asymmetric Y chromosomes.
abstract: Two patients were referred because of oligospermia and azospermia, respectively. Karyotypic analysis revealed two mosaic-YY males carrying asymmetric Y chromosomes. To our knowledge, no instance of double unequal Y chromosomes has been reported so far in human males. Results of fluorescent in situ hybridization (FISH) studies in spermatozoa from one of these patients revealed a significantly high number of hyperaploid spermatozoa.
authors.affiliation: Servizio di Genetica Medica, IRCCS, Ospedale CSS San Giovanni Rotondo, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Zelante
authors.forename: B
authors.initials: B
authors.lastname: Dallapiccola
authors.forename: S
authors.initials: S
authors.lastname: Calvano
authors.forename: E
authors.initials: E
authors.lastname: Memeo
authors.forename: P
authors.initials: P
authors.lastname: Gasparini
authors.forename: P
authors.initials: P
authors.lastname: Simi
authors.forename: S
authors.initials: S
authors.lastname: Rossi
authors.forename: P
authors.initials: P
authors.lastname: Finelli
authors.forename: M
authors.initials: M
authors.lastname: Rocchi
authors.forename: N
authors.initials: N
authors.lastname: Archidiacono
mesh_terms: D000328:Adult; D002869:Chromosome Aberrations; D003456:Cryptorchidism / Q000601:surgery; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D008297:Male; D009030:Mosaicism; D009845:Oligospermia / Q000235:genetics*; D011247:Pregnancy; D013094:Spermatozoa / Q000502:physiology; D013737:Testis / Q000473:pathology; D014998:Y Chromosome