The human basonuclin gene.
The human gene for basonuclin, a zinc-finger protein of keratinocytes, has been cloned, sequenced and assigned to chromosome 15. The transcription unit spans nearly 29 kb of sequence. The coding region is distributed over five exons, and the three pairs of zinc fingers are encoded by the last two. The 5' flanking sequence and first exon are unusually rich in G+C and in CpG dinucleotides. This region contains numerous target sites for the transcription factor Sp1.
Teumer
J
J
Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
Tseng
H
H
Green
H
H
D000595:Amino Acid Sequence; D000818:Animals; D001482:Base Composition; D001483:Base Sequence; D002874:Chromosome Mapping; D002884:Chromosomes, Human, Pair 15; D003001:Cloning, Molecular; D018076:DNA, Complementary; D004268:DNA-Binding Proteins; D005091:Exons; D006801:Humans; D006822:Hybrid Cells; D007438:Introns; D008969:Molecular Sequence Data; D010750:Phosphoproteins; D011506:Proteins / Q000235:genetics*; D012377:Rodentia; D014157:Transcription Factors; D016335:Zinc Fingers / Q000235:genetics
D018076:DNA, Complementary; D004268:DNA-Binding Proteins; D010750:Phosphoproteins; D011506:Proteins; D014157:Transcription Factors; C077914:BNC1 protein, human