Aflastatin A, a novel inhibitor of aflatoxin production by aflatoxigenic fungi.
Aflastatin A, a novel inhibitor of the production of aflatoxin by aflatoxigenic fungi, has been isolated from the solvent extract of mycelial cake of Streptomyces sp. and its molecular formula was determined as C62H115NO24. Aflastatin A completely inhibited aflatoxin production by Aspergillus parasiticus NRRL 2999 in liquid medium or on agar plate at a concentration of 0.5 microgram/ml. The mycelial growth of this fungus was not affected in the liquid medium at the same concentration, while the hyphal extension rate was reduced on the plate together with some morphological changes. The growth of the fungus was not completely inhibited even at a concentration of 100 micrograms/ml. Aflastatin A exhibits antimicrobial activity against some bacteria, yeasts and fungi as well as antitumor activity.
Ono
M
M
Research Institute, Morinaga and Co., Ltd., Yokohama, Japan.
Sakuda
S
S
Suzuki
A
A
Isogai
A
A
D000348:Aflatoxins / Q000096:biosynthesis*; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000903:Antibiotics, Antineoplastic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001230:Aspergillus / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004353:Drug Evaluation, Preclinical; D004352:Drug Resistance, Microbial; D008826:Microbial Sensitivity Tests; D008854:Microscopy, Electron; D015394:Molecular Structure; D011760:Pyrrolidinones; D013302:Streptomyces / Q000737:chemistry / Q000648:ultrastructure
D000348:Aflatoxins; D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; D000935:Antifungal Agents; D011760:Pyrrolidinones; C105377:aflastatin A