Relationship between upper gastrointestinal bleeding and non steroidal anti-inflammatory drugs in children.
The authors evaluated the relationship between drug intake and upper gastrointestinal (GI) bleeding. The endoscopic files of the previous 2 years were reviewed and the incidence and age and sex distribution recorded. GI bleeding is indication for a high percentage of lower endoscopies and a low percentage of upper endoscopies. On the other hand, although rarer upper GI bleeding is more severe and frequently related to drug ingestion. About 50% of cases showed gastric erosions secondary to drug intake. A relation between gastric bleeding and paracetamol is considered, as is the possibility of preventing secondary severe bleeding by pharmacologic gastric protection in children with risk factors such as chronic use of other drugs or portal hypertension.
Li Voti
G
G
Department of Pediatric Surgery, Palermo University, via Cardinale Rampolla 1, I-90142 Palermo, Italy.
Acierno
C
C
Tulone
V
V
Cataliotti
F
F
D000082:Acetaminophen / Q000009:adverse effects*; D018712:Analgesics, Non-Narcotic / Q000009:adverse effects*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D002675:Child, Preschool; D005260:Female; D005756:Gastritis / Q000139:chemically induced / Q000453:epidemiology; D006396:Hematemesis / Q000139:chemically induced* / Q000453:epidemiology; D006801:Humans; D008297:Male; D012189:Retrospective Studies
D018712:Analgesics, Non-Narcotic; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000082:Acetaminophen