title: Effect of L364.718 during suckling on the sensitivity to the hypophagic effect of cholecystokinin in adult rats.
abstract: 1. In the present study it was investigated whether drugs acting at the cholecystokinin (CCK)-A receptor given to rat pups may result in long-lasting changes in body weight or regulation of food intake controlled by CCK. 2. From day 3 to day 10 of life, male and female Wistar rat pups were treated with the CCK-A receptor antagonist L-364.718 and the CCK-A + B agonist CCK-8S. 3. In adult rats, treated with L364.718 during suckling, the sensitivity to the acute hypophagic action of CCK-8S was weaker or abolished compared to adults treated with saline during suckling. In adult rats given CCK-8S during suckling acute treatment with CCK-8S reduced food intake to the same extent as in the group treated with saline postnatally. 4. These data show that early postnatal treatment with the CCK-A receptor antagonist L364.718 has an impact on the hypophagic response to CCK-8S in later life.
authors.affiliation: Institute of Pharmacology and Toxicology, Medical Faculty (Charité), Humboldt University, Berlin, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Voits
authors.forename: S
authors.initials: S
authors.lastname: Rödel
authors.forename: S
authors.initials: S
authors.lastname: Förster
authors.forename: A
authors.initials: A
authors.lastname: Plagemann
authors.forename: H
authors.initials: H
authors.lastname: Fink
mesh_terms: D000818:Animals; D001570:Benzodiazepinones / Q000494:pharmacology*; D001835:Body Weight / Q000187:drug effects*; D020109:Devazepide; D004435:Eating / Q000187:drug effects*; D005260:Female; D006727:Hormone Antagonists / Q000494:pharmacology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D011949:Receptors, Cholecystokinin / Q000187:drug effects*; D012737:Sex Factors; D012844:Sincalide / Q000494:pharmacology
chemical_list: D001570:Benzodiazepinones; D006727:Hormone Antagonists; D011949:Receptors, Cholecystokinin; D020109:Devazepide; D012844:Sincalide