Long-term potentiation and depression in layer III and V pyramidal neurons of the cat sensorimotor cortex in vitro.
Synaptic plasticity of the cat sensorimotor cortex was examined intracellularly in vitro. After tetanic stimulation of the white matter, layer III and V pyramidal neurons showed long-term potentiation (LTP) of EPSPs in high incidence without GABA(A) antagonist. The incidence and magnitude of LTP were very conspicuous in layer V cells. After an NMDA receptor antagonist application, the synaptic potentiation was blocked completely in layer III but not in layer V cells. Long-term depression (LTD) of the evoked EPSPs was also induced by the same stimulation in some layer III cells, where a transient hyperpolarization of the membrane potential was observed during tetanus.
Kitagawa
H
H
Department of Physiology, Faculty of Medicine, Mie University, Tsu Mie, Japan. kitagawa@doc.medic.mie-u.ac.jp
Nishimura
Y
Y
Yoshioka
K
K
Lin
M
M
Yamamoto
T
T
D015763:2-Amino-5-phosphonovalerate / Q000494:pharmacology; D000818:Animals; D002415:Cats; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology; D066298:In Vitro Techniques; D017774:Long-Term Potentiation; D009044:Motor Cortex / Q000166:cytology / Q000502:physiology*; D009473:Neuronal Plasticity; D017966:Pyramidal Cells / Q000502:physiology*; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors / Q000502:physiology; D013003:Somatosensory Cortex / Q000166:cytology / Q000502:physiology*; D009435:Synaptic Transmission / Q000187:drug effects
D018691:Excitatory Amino Acid Antagonists; D016194:Receptors, N-Methyl-D-Aspartate; D015763:2-Amino-5-phosphonovalerate