title: [The characteristics of the effect of obzidan on the cardiac hemodynamics in patients with an artificial pacemaker when used one time and over a course of treatment].
abstract: ECG investigations of cardiodynamics were performed in 47 patients subjected to isolated ventricular electrocardiostimulation on obsidan treatment. The drug was given in a single dose or in a course. Cardiodynamic effects were evaluated in 3 groups of patients: with hyperkinetic, eukinetic and hypokinetic circulation (17, 19 and 11 patients, respectively). Cardiohemodynamic effects of obsidan are shown to depend on type of circulation and features of intracardiac hemodynamics (fixed cardiac rhythm, atrioventricular dissociation, pathological ventricular asynchronism, valvular blood regurgitation). This potentiates cardiodepressive effects of obsidan in patients with hypokinetic circulation who experience deterioration of cardiac insufficiency.
authors.forename: B G
authors.initials: BG
authors.lastname: Iskenderov
authors.forename: I P
authors.initials: IP
authors.lastname: Tatarchenko
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage* / Q000494:pharmacology*; D000328:Adult; D000368:Aged; D002908:Chronic Disease; D003131:Combined Modality Therapy; D005260:Female; D006321:Heart / Q000187:drug effects* / Q000503:physiopathology; D006327:Heart Block / Q000209:etiology / Q000503:physiopathology / Q000628:therapy; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000150:complications / Q000503:physiopathology; D010138:Pacemaker, Artificial; D011433:Propranolol / Q000008:administration & dosage* / Q000494:pharmacology*
chemical_list: D000319:Adrenergic beta-Antagonists; D011433:Propranolol
vernacular_title: Osobennosti vliianiia obzidana na kardiogemodinamiku bol'nykh s iskusstvennym voditelem ritma serdtsa pri odnokratnom i kursovom primenenii.