title: Beta-carotene did not work: aftermath of the ATBC study.
abstract: The results of the ATBC study, the first large intervention trial of antioxidants, were intriguing. While the possibility that beta-carotene may in some circumstances enhance carcinogenesis has now been confirmed in another large trial, the mechanisms of action remain obscure.
authors.affiliation: National Public Health Institute, Helsinki, Finland. matti.rautalahti@ktl.fi
authors.forename: M
authors.initials: M
authors.lastname: Rautalahti
authors.forename: D
authors.initials: D
authors.lastname: Albanes
authors.forename: J
authors.initials: J
authors.lastname: Virtamo
authors.forename: P R
authors.initials: PR
authors.lastname: Taylor
authors.forename: J K
authors.initials: JK
authors.lastname: Huttunen
authors.forename: O P
authors.initials: OP
authors.lastname: Heinonen
mesh_terms: D000368:Aged; D006801:Humans; D008175:Lung Neoplasms / Q000517:prevention & control*; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000517:prevention & control; D012907:Smoking; D014810:Vitamin E / Q000627:therapeutic use; D019207:beta Carotene / Q000627:therapeutic use*
chemical_list: D019207:beta Carotene; D014810:Vitamin E