title: Acute exposure to a 60 Hz magnetic field increases DNA strand breaks in rat brain cells.
abstract: Acute (2 h) exposure of rats to a 60 Hz magnetic field (flux densities 0.1, 0.25, and 0.5 mT) caused a dose-dependent increase in DNA strand breaks in brain cells of the animals (assayed by a microgel electrophoresis method at 4 h postexposure). An increase in single-strand DNA breaks was observed after exposure to magnetic fields of 0.1, 0.25, and 0.5 mT, whereas an increase in double-strand DNA breaks was observed at 0.25 and 0.5 mT. Because DNA strand breaks may affect cellular functions, lead to carcinogenesis and cell death, and be related to onset of neurodegenerative diseases, our data may have important implications for the possible health effects of exposure to 60 Hz magnetic fields.
authors.affiliation: Bioelectromagnetics Research Laboratory, University of Washington, Seattle 98195, USA.
authors.forename: H
authors.initials: H
authors.lastname: Lai
authors.forename: N P
authors.initials: NP
authors.lastname: Singh
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001921:Brain / Q000166:cytology / Q000528:radiation effects*; D004249:DNA Damage / Q000235:genetics / Q000528:radiation effects*; D004260:DNA Repair / Q000528:radiation effects; D004574:Electromagnetic Fields / Q000009:adverse effects*; D004587:Electrophoresis, Agar Gel; D004781:Environmental Exposure / Q000009:adverse effects; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley