title: Cytogenetic analysis of several pseudomyxoma peritonei lesions originating from a mucinous cystadenoma of the appendix.
abstract: Epithelial proliferative lesions of the appendix are rare and have never been studied cytogenetically. We present the chromosomal banding analysis of four successfully short-term cultured samples from pseudomyxoma peritonei lesions originating from a cystadenoma of the appendix. All four sample contained clonal chromosome abnormalities. In three of them, the clone 46,XX,der(6)?del(6)(q16q21)?del(6)(q27) was found, whereas a clone with the karyotype 46,XX,t(2;17)(p21;p13),t(6;12)(p21;q13),t(12;15)(q24;q15) was detected in the fourth sample. Our findings support the view that pseudomyxoma peritonei originates by spreading from a primary mucinous neoplasm of an intraperitoneal organ rather than through mucinous metaplasia or multifocal primary neoplastic transformation of the peritoneum.
authors.affiliation: Department of Genetics, Norwegian Radium Hospital, Oslo, Norway.
authors.forename: M R
authors.initials: MR
authors.lastname: Teixeira
authors.forename: H
authors.initials: H
authors.lastname: Qvist
authors.forename: K E
authors.initials: KE
authors.lastname: Giercksky
authors.forename: P J
authors.initials: PJ
authors.lastname: Bøhler
authors.forename: S
authors.initials: S
authors.lastname: Heim
mesh_terms: D000328:Adult; D001063:Appendiceal Neoplasms / Q000235:genetics* / Q000473:pathology; D002869:Chromosome Aberrations; D002896:Chromosomes, Human, Pair 6 / Q000235:genetics; D018291:Cystadenoma, Mucinous / Q000235:genetics* / Q000473:pathology; D006801:Humans; D007621:Karyotyping; D008297:Male; D011553:Pseudomyxoma Peritonei / Q000235:genetics*