title: Interleukin-10 in preovulatory follicular fluid of patients undergoing in-vitro fertilization and embryo transfer.
abstract: OBJECTIVE
  The present study aimed at investigating the presence of Interleukin-10 (IL-10) in preovulatory follicular fluid (FF) and its possible correlation with 17-beta-estradiol (E2) and progesterone (P) levels, and treatment outcome in patients undergoing in-vitro fertilization-embryo transfer (IVF-ET).
  
  
  METHODS
  Twenty consecutive patients with tubal factor infertility who underwent oocyte retrieval for IVF-ET were assayed for pooled, preovulatory FF levels of IL-10, E2, and P.
  
  
  RESULTS
  The mean FF levels of IL-10, E2, and P were 78.7 +/- 104.7 pg/ml, 2,787.0 +/- 726.1 pg/ml, and 1.5 +/- 0.8 ng/ml, respectively. No correlation was found between preovulatory FF concentration of IL-10, E2, oocyte number, oocyte fertilization rate, embryo quality, and pregnancy rate. The levels of IL-10 were found to be negatively correlated with P concentration, although not significantly (P = 0.057).
  
  
  CONCLUSIONS
  Interleukin-10 exists in the preovulatory FF. Further investigations are needed to determine the role of IL-10 in the folliculogenesis.
authors.affiliation: In-Vitro Fertilization Unit, Serlin Maternity Hospital, Tel Aviv University, Israel.
authors.forename: E
authors.initials: E
authors.lastname: Geva
authors.forename: J B
authors.initials: JB
authors.lastname: Lessing
authors.forename: L
authors.initials: L
authors.lastname: Lerner-Geva
authors.forename: F
authors.initials: F
authors.lastname: Azem
authors.forename: I
authors.initials: I
authors.lastname: Yovel
authors.forename: D
authors.initials: D
authors.lastname: Ben-Yosef
authors.forename: U
authors.initials: U
authors.lastname: Barkai
authors.forename: A
authors.initials: A
authors.lastname: Amit
mesh_terms: D000328:Adult; D004624:Embryo Transfer; D004958:Estradiol / Q000378:metabolism; D005260:Female; D005307:Fertilization in Vitro; D015571:Follicular Fluid / Q000737:chemistry / Q000378:metabolism*; D005498:Follicular Phase / Q000276:immunology*; D006801:Humans; D016753:Interleukin-10 / Q000378:metabolism*; D011374:Progesterone / Q000378:metabolism
chemical_list: D016753:Interleukin-10; D011374:Progesterone; D004958:Estradiol