Measurement and metabolism of isoflavonoids and lignans in the human male.
Asian men, who consume a low fat/high fibre soya-based diet, have very much lower incidence of prostate cancer than men from North America and Europe. The soya bean is a rich source of the isoflavonic phyto-oestrogens, daidzein, genistein and equol, compounds which may be cancer-protective in Asian populations. The lignans, enterolactone and enterodiol, plant oestrogens derived from cereals and vegetables, may act in a similar manner in vegetarian men. We report here on the measurement of isoflavonoids and lignans, by gas chromatography-mass spectrometry, in prostatic fluid of men from Asia and Europe and also on the metabolism of these compounds in Western men following dietary supplementation.
Morton
M S
MS
Tenovus Cancer Research Centre, U.W.C.M., Cardiff, UK.
Matos-Ferreira
A
A
Abranches-Monteiro
L
L
Correia
R
R
Blacklock
N
N
Chan
P S
PS
Cheng
C
C
Lloyd
S
S
Chieh-ping
W
W
Griffiths
K
K
D000328:Adult; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D007529:Isoflavones / Q000032:analysis* / Q000378:metabolism*; D017705:Lignans / Q000032:analysis* / Q000378:metabolism*; D008043:Linseed Oil / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011467:Prostate / Q000378:metabolism*; D013025:Glycine max / Q000378:metabolism*; D013997:Time Factors
D007529:Isoflavones; D017705:Lignans; D008043:Linseed Oil