Upper limit for intestinal absorption of a dilute glucose solution in men at rest.
We studied gastric and intestinal function by gastric intubation/intestinal perfusion in six healthy male volunteers to evaluate optimal use of a 6% glucose-electrolyte (GES) solution. Gastric volume, residual volume, emptying rate, and secretion were measured for an initial 763 +/- 19 ml gastric load of GES and at the beginning and end of four additional gastric loads (2.2 ml.kg-1; approximately 180 ml) given at 10-min intervals. The relatively high gastric (713 +/- 58 ml) and residual (507 +/- 26 ml) volumes maintained a high gastric emptying rate (19.5 +/- 1.4 ml.min-1). Composition of the GES emptied into the duodenum was also measured in this first experiment. In a second experiment, this modified solution was infused (triple lumen tube) into the duodenum at a rate equal to gastric emptying rate, or at 38 or 77% greater rates. Absorption of water (11.3-12.9 ml.h-1.cm-1) and glucose 4.3-5.6 mmol.h-1.cm-1) were similar at all perfusion rates during the second experiment. We conclude that duodenojejunal segmental absorption rates of water and glucose produced by a rapid, sustained gastric emptying rate cannot be increased by delivering a greater load of glucose and water by intestinal perfusion.
Duchman
S M
SM
Department of Exercise Science, University of Iowa, Iowa City 52242, USA.
Ryan
A J
AJ
Schedl
H P
HP
Summers
R W
RW
Bleiler
T L
TL
Gisolfi
C V
CV
D000328:Adult; D004386:Duodenum / Q000502:physiology; D004573:Electrolytes / Q000008:administration & dosage; D005746:Gastric Emptying / Q000502:physiology*; D005947:Glucose / Q000008:administration & dosage / Q000378:metabolism*; D006801:Humans; D007408:Intestinal Absorption / Q000502:physiology*; D007441:Intubation, Gastrointestinal; D008297:Male; D015532:Rehydration Solutions / Q000378:metabolism*; D012146:Rest
D004573:Electrolytes; D015532:Rehydration Solutions; D005947:Glucose