title: Candida tropicalis arthritis in a patient with acute myeloid leukemia successfully treated with fluconazole: case report and review of the literature.
abstract: The case of a 77-year-old woman with acute myeloid leukemia who developed Candida tropicalis septic arthritis of the knee after remission-inducing chemotherapy is reported. A literature review of C. tropicalis non-prosthetic arthritis is included. The isolate was susceptible to fluconazole (MIC 0.25 mg/l). She was treated with fluconazole (400 mg orally) and frequent relieving synovial aspirations. After 1 month of antifungal therapy the synovial fluid became culture negative. Fluconazole concentration in the synovial fluid and serum were 20 mg/l and 19.4 mg/l, respectively. The patient was treated for a total of 7 months and made a full recovery. This is the first report of the successful use of fluconazole in the treatment of septic arthritis due to C. tropicalis.
authors.affiliation: Dept. of Medical Microbiology, Bosch Medicentrum, Den Bosch, The Netherlands.
authors.forename: G
authors.initials: G
authors.lastname: Weers-Pothoff
authors.forename: J F
authors.initials: JF
authors.lastname: Havermans
authors.forename: J
authors.initials: J
authors.lastname: Kamphuis
authors.forename: H A
authors.initials: HA
authors.lastname: Sinnige
authors.forename: J F
authors.initials: JF
authors.lastname: Meis
mesh_terms: D000368:Aged; D000935:Antifungal Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001170:Arthritis, Infectious / Q000150:complications* / Q000188:drug therapy*; D002177:Candidiasis / Q000150:complications* / Q000188:drug therapy*; D002648:Child; D005260:Female; D015725:Fluconazole / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007231:Infant, Newborn; D007717:Knee / Q000382:microbiology; D015470:Leukemia, Myeloid, Acute / Q000150:complications*; D008297:Male; D008875:Middle Aged; D012782:Shoulder / Q000382:microbiology
chemical_list: D000935:Antifungal Agents; D015725:Fluconazole