title: Coeliac disease in Galway, Ireland 1971-1990.
abstract: Recent studies have reported changes in the incidence of coeliac disease and in its presentation. We carried out a retrospective study looking at the incidence and clinical features of coeliac disease in Galway children over a 20 year period. The study period was divided in two parts. (I) Patients diagnosed between 1971 and 1980 and (II) between 1981 and 1990. Comparison was made between demographic and clinical data in these two periods. There were 97 cases of coeliac disease diagnosed in children resident in Galway over the 20 year period. 71 patients were diagnosed in period I and 26 in period II. The median age at diagnosis in period I was 1.41 years and 4.95 years in period II. There were more females diagnosed in period I. Growth data, histology and enzyme levels were similar in both groups. Diarrhoea and vomiting were the major presenting symptoms in both periods but more patients presented with wasting or abdominal protuberance in the latter period. Our data support the concept that coeliac disease in childhood is declining, and is presenting at a later age.
authors.affiliation: Department of Paediatrics, University College Hospital Galway.
authors.forename: S N
authors.initials: SN
authors.lastname: Gumaa
authors.forename: B
authors.initials: B
authors.lastname: McNicholl
authors.forename: B
authors.initials: B
authors.lastname: Egan-Mitchell
authors.forename: K
authors.initials: K
authors.lastname: Connolly
authors.forename: B G
authors.initials: BG
authors.lastname: Loftus
mesh_terms: D000293:Adolescent; D002446:Celiac Disease / Q000453:epidemiology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D007494:Ireland / Q000453:epidemiology; D008297:Male; D015995:Prevalence; D012189:Retrospective Studies