[The efficacy and reactogenicity of a cell-free staphylococcal vaccine in the immunotherapy of patients with chronic pyodermas].
The clinical effectiveness, reactogenicity and immunological activity of cell free staphylococcal vaccine in the immunotherapy of chronic pyoderma patients under the conditions of controlled trials were studied. Immunotherapy was carried out in combination with traditional methods of treatment. A group of 39 patient received cell free staphylococcal vaccine subcutaneously; the second control group (30 patients) received the commercial preparation of staphylococcal antiphagin and the third group (31 patients) was treated by traditional methods without vaccines. The study revealed that cell free staphylococcal vaccine had low reactogenicity and was well tolerated by patients; in contrast to the methods of treatment in the control groups, the vaccine stimulated an increased levels of specific antibodies and IgA in the blood of the patients. Immunotherapy with cell free staphylococcal vaccine led to clinical convalescence and remission in 1-3 years (the term of observation) in 71.8% of cases. In the two control groups such effect did not exceed 23%.
Efremova
V N
VN
Egorova
N B
NB
Masiukova
S A
SA
Kuz'mina
L A
LA
Gervazieva
V B
VB
D016009:Chi-Square Distribution; D002908:Chronic Disease; D003131:Combined Modality Therapy; D004359:Drug Therapy, Combination; D006801:Humans; D007136:Immunoglobulins / Q000097:blood / Q000187:drug effects; D011711:Pyoderma / Q000276:immunology / Q000628:therapy*; D012074:Remission Induction; D013207:Staphylococcal Skin Infections / Q000276:immunology / Q000628:therapy*; D013209:Staphylococcal Vaccines / Q000009:adverse effects / Q000627:therapeutic use*; D013997:Time Factors
D007136:Immunoglobulins; D013209:Staphylococcal Vaccines; C034359:antifagin
Effektivnost' i reaktogennost' beskletochnoĭ stafilokokkovoĭ vaktsiny pri immunoterapii bol'nykh khronicheskimi piodermiiami.