title: The effect of oral quercetin on UVB-induced tumor growth and local immunosuppression in SKH-1.
abstract: The effects of quercetin (4%) on UVB-induced carcinogenesis and immunosuppression were studied in hairless SKH-1 mice exposed daily to suberythemal UVB for 12/13 and 16/17 weeks. Macroscopic and microscopic examinations showed that quercetin did not affect the onset and growth of UVB-induced non-melanoma skin tumors. Quercetin prevented the UV-induced suppression of the contact hypersensitivity (CHS) and the reduction of the percentage of CD8-positive cells in spleen and lymph nodes. Other immunological parameters were not affected. Thus, the results indicate that oral intake of a high dose of quercetin does not prevent UVB-induced carcinogenesis, although it restores the skin-associated CHS response.
authors.affiliation: National Institute of Public Health and the Environment, Laboratory for Pathology and Immunobiology, Bilthoven, The Netherlands.
authors.forename: P A
authors.initials: PA
authors.lastname: Steerenberg
authors.forename: J
authors.initials: J
authors.lastname: Garssen
authors.forename: P M
authors.initials: PM
authors.lastname: Dortant
authors.forename: H
authors.initials: H
authors.lastname: van der Vliet
authors.forename: E
authors.initials: E
authors.lastname: Geerse
authors.forename: A P
authors.initials: AP
authors.lastname: Verlaan
authors.forename: W G
authors.initials: WG
authors.lastname: Goettsch
authors.forename: Y
authors.initials: Y
authors.lastname: Sontag
authors.forename: H B
authors.initials: HB
authors.lastname: Bueno-de-Mesquita
authors.forename: H
authors.initials: H
authors.lastname: Van Loveren
mesh_terms: D000284:Administration, Oral; D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D003877:Dermatitis, Contact; D051379:Mice; D008815:Mice, Inbred Strains; D009381:Neoplasms, Radiation-Induced / Q000473:pathology*; D011794:Quercetin / Q000008:administration & dosage / Q000494:pharmacology*; D012878:Skin Neoplasms / Q000276:immunology / Q000473:pathology*; D014466:Ultraviolet Rays
chemical_list: D011794:Quercetin