title: Intra-operative gas exchange and post-operative hypoxaemia.
abstract: The relation between intra-operative gas exchange and post-operative oxygen saturation was examined using pulse oximetry (SpO2) 30 h after anaesthesia for upper abdominal surgery. The inspired oxygen partial pressure (PIO2) was varied during anaesthesia to produce a plot of PIO2 vs. SpO2. Gas exchange during anaesthesia was inferred from the relation between PIO2 and SpO2 which was described by its lateral and vertical displacement away from the position of a standard oxygen dissociation curve. With patients breathing air, the SpO2 was measured over a 10-min period at 30 h after surgery. The correlation coefficient of the lateral displacement with post-operative SpO2 was 0.7, and that of the vertical displacement with post-operative SpO2 was 0.66. The correlation coefficient of intra-operative SpO2 at PIO2 = 21 kPa with post-operative SpO2 was 0.69. It can be concluded that gas exchange abnormalities during anaesthesia deduced from the displacement of the PIO2 vs. SpO2 curve correlate with SpO2 30 h post-operatively and may help to identify patients at risk of post-operative hypoxaemia.
authors.affiliation: University Department of Anaesthesia, Addenbrookes Hospital, Cambridge, UK.
authors.forename: P G
authors.initials: PG
authors.lastname: Roe
authors.forename: R
authors.initials: R
authors.lastname: Gadelrab
authors.forename: D
authors.initials: D
authors.lastname: Sapsford
authors.forename: J G
authors.initials: JG
authors.lastname: Jones
mesh_terms: D000005:Abdomen / Q000601:surgery; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001785:Blood Gas Monitoring, Transcutaneous; D005260:Female; D006452:Hemoglobinometry; D006801:Humans; D000860:Hypoxia / Q000097:blood*; D007432:Intraoperative Period; D008297:Male; D008875:Middle Aged; D010092:Oximetry; D011183:Postoperative Complications / Q000097:blood* / Q000503:physiopathology; D011659:Pulmonary Gas Exchange / Q000502:physiology*