title: Bilateral versus single lung transplantation for chronic obstructive pulmonary disease.
abstract: OBJECTIVE
  Traditionally, despite ventilation/perfusion mismatch, single lung transplantation has been the mainstay for end-stage chronic obstructive pulmonary disease. We tested the hypothesis that bilateral sequential lung transplantation has better short- and intermediate-term results than single lung transplantation for chronic obstructive pulmonary disease.
  
  
  METHODS
  One hundred twenty-six consecutive lung transplants have been performed from November 1991 to March 1996. Seventy-six have been for chronic obstructive pulmonary disease. The diagnosis of this disease includes emphysema (80.3%), alpha 1-antitrypsin deficiency (9.2%), lymphangioleiomyomatosis (7.9%), and obliterative bronchiolitis (2.6%). Twenty-nine transplants have been bilateral and 47 have been single. Mean age was 55.3 for patients having single lung transplantation and 48.8 for those having bilateral lung transplantation (p = 0.001). The distribution of the diagnoses was similar between the two groups. At 6 months, there were 29 survivors of single lung transplantation and 20 survivors of bilateral lung transplantation, with complete data for evaluation. Pulmonary function tests and 6-minute walk tests were evaluated at a mean of 15.4 and 12.8 months after transplantation, respectively.
  
  
  RESULTS
  Sixty-day mortality was 21.3% for single lung transplantation versus only 3.45% for bilateral lung transplantation (p = 0.03). Additionally, Kaplan-Meier analysis revealed 1- and 2-year survivals of 71.1% and 63.3% for single lung transplantation versus 90% and 90% for bilateral lung transplantation, respectively. Multiple major morbidities were analyzed. Primary graft failure was significantly reduced in the bilateral group (p = 0.049). Both 6-minute walk tests and forced expiratory volume in 1 second were improved from baseline by both single and bilateral lung transplantation (p = 0.001).
  
  
  CONCLUSIONS
  Bilateral lung transplantation improves forced expiratory volume in 1 second and 6-minute walk tests significantly over single lung transplantation (p < 0.0001). Both perioperative mortality and Kaplan-Meier survival (to 3 years) are significantly improved when bilateral rather than single lung transplantation is used for chronic obstructive pulmonary disease in our series (p < 0.05). This is probably the result of significantly reduced primary graft failure.
authors.affiliation: Department of Cardiothoracic Surgery, University of Pennsylvania Medical Center, Philadelphia, USA.
authors.forename: J E
authors.initials: JE
authors.lastname: Bavaria
authors.forename: R
authors.initials: R
authors.lastname: Kotloff
authors.forename: H
authors.initials: H
authors.lastname: Palevsky
authors.forename: B
authors.initials: B
authors.lastname: Rosengard
authors.forename: J R
authors.initials: JR
authors.lastname: Roberts
authors.forename: P M
authors.initials: PM
authors.lastname: Wahl
authors.forename: N
authors.initials: N
authors.lastname: Blumenthal
authors.forename: C
authors.initials: C
authors.lastname: Archer
authors.forename: L R
authors.initials: LR
authors.lastname: Kaiser
mesh_terms: D000368:Aged; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D008171:Lung Diseases / Q000401:mortality / Q000503:physiopathology; D008173:Lung Diseases, Obstructive / Q000601:surgery*; D016040:Lung Transplantation / Q000379:methods* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D015996:Survival Rate; D016896:Treatment Outcome; D014797:Vital Capacity