Architecture and function in the muscle sarcomere.
Striated muscle sarcomeres in vertebrates comprise ordered arrays of actin and myosin filaments, organized by an elaborate protein scaffold. Recent innovative work in a number of laboratories has greatly improved our knowledge of these structures, their organization and their interactions. Structural details have been reported on myosin filaments, actin filaments, Z-bands, M-bands, titin, and nebulin. Time-resolved X-ray diffraction and electron microscopy are revealing the molecular movements involved in force production and regulation.
Squire
J M
JM
Biophysics Section, Blackett Laboratory, Imperial College, London, SW7 2BZ, UK. j.squire@ic.ac.uk
D000199:Actins / Q000648:ultrastructure; D000818:Animals; D002352:Carrier Proteins / Q000648:ultrastructure; D064211:Connectin; D008958:Models, Molecular; D009119:Muscle Contraction; D009124:Muscle Proteins / Q000648:ultrastructure*; D009132:Muscles / Q000648:ultrastructure; D009218:Myosins / Q000648:ultrastructure; D011494:Protein Kinases / Q000648:ultrastructure; D012518:Sarcomeres / Q000648:ultrastructure*; D014961:X-Ray Diffraction
D000199:Actins; D002352:Carrier Proteins; D064211:Connectin; D009124:Muscle Proteins; D011494:Protein Kinases; D009218:Myosins