Alcohol intake decreases brain Zonisamide concentration in inbred EL mice.
This study was undertaken to evaluate the effect of ethanol intake on the anticonvulsive effects of Zonisamide (ZNS), a sulfonamide derivative. EL mice, which are highly susceptible to seizures, were given a 10% ethanol solution ad lib for 1-4 weeks. In mice given ethanol for 4 weeks, seizures were not suppressed by ZNS at a dose of 75 mg kg-1, i.p. Serum ZNS concentrations following ethanol consumption for 1-4 weeks were higher than in untreated mice; however, brain ZNS concentrations following ethanol consumption were lower than those in untreated mice. These results suggest that alcohol intake decreases the brain concentration of ZNS, but not the serum concentration.
Nagatomo
I
I
Department of Neuropsychiatry, Faculty of Medicine, Kagoshima University, Japan.
Akasaki
Y
Y
Uchida
M
M
Takigawa
M
M
D000818:Animals; D000927:Anticonvulsants / Q000378:metabolism*; D001921:Brain / Q000187:drug effects*; D000431:Ethanol / Q000494:pharmacology*; D007555:Isoxazoles / Q000378:metabolism*; D051379:Mice; D000078305:Zonisamide
D000927:Anticonvulsants; D007555:Isoxazoles; D000431:Ethanol; D000078305:Zonisamide