title: Methotrexate pneumonitis after systemic treatment for ectopic pregnancy.
abstract: Pneumonitis is an infrequent complication of methotrexate therapy. Described is a case of pneumonitis after treatment of an ectopic pregnancy. A 20-year-old white woman, gravida 3, para 0, ectopic pregnancy 2, was treated for her third ectopic pregnancy with 88 mg (50 mg/m2) of intramuscular methotrexate. Four days later acute dyspnea, tachypnea, fever, patchy infiltrates on chest x-ray films, and a PO2 of 30 mm Hg developed. Respiratory distress resolved over 48 hours. Pneumonitis should be suspected in any patient treated with methotrexate who has unexplained dyspnea.
authors.affiliation: Department of Obstetrics and Gynecology, Medical College of Ohio, Toledo 43699-0008, USA.
authors.forename: T J
authors.initials: TJ
authors.lastname: Horrigan
authors.forename: J
authors.initials: J
authors.lastname: Fanning
authors.forename: M P
authors.initials: MP
authors.lastname: Marcotte
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008727:Methotrexate / Q000009:adverse effects*; D011014:Pneumonia / Q000139:chemically induced*; D011247:Pregnancy; D011274:Pregnancy, Tubal / Q000188:drug therapy*; D012422:Rupture, Spontaneous
chemical_list: D008727:Methotrexate