title: Does subclinical hypothyroidism explain the increased susceptibility of women to torsades de pointes?
abstract: Among 20 consecutive patients (65% women) with drug-associated torsades de pointes, chemical evidence for hypothyroidism was found in only 10% of both women and men. Subclinical hypothyroidism is therefore unlikely to account for the consistently observed sex difference in the propensity to torsades de pointes.
authors.affiliation: The Arrhythmia Center and Department of Medicine/Sinai Hospital, Detroit, Michigan 48235, USA.
authors.forename: M H
authors.initials: MH
authors.lastname: Lehmann
authors.forename: D
authors.initials: D
authors.lastname: Frankovich
authors.forename: J J
authors.initials: JJ
authors.lastname: Baga
authors.forename: L A
authors.initials: LA
authors.lastname: Pires
authors.forename: C D
authors.initials: CD
authors.lastname: Schuger
authors.forename: R T
authors.initials: RT
authors.lastname: Steinman
authors.forename: S L
authors.initials: SL
authors.lastname: Rabinowe
mesh_terms: D000368:Aged; D000889:Anti-Arrhythmia Agents / Q000009:adverse effects* / Q000627:therapeutic use; D004198:Disease Susceptibility; D004562:Electrocardiography; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology; D008297:Male; D012307:Risk Factors; D012737:Sex Factors; D016171:Torsades de Pointes / Q000139:chemically induced* / Q000453:epidemiology / Q000209:etiology
chemical_list: D000889:Anti-Arrhythmia Agents