title: Reduced asthma symptoms with n-3 fatty acid ingestion are related to 5-series leukotriene production.
abstract: Asthma may respond to dietary modification, thereby reducing the need for pharmacologic agents. This study determined the effectiveness of n-3 polyunsaturated fatty acid (PUFA) ingestion in ameliorating methacholine-induced respiratory distress in an asthmatic population. The ability of urinary leukotriene excretion to predict efficacy of n-3 PUFA ingestion was assessed. After n-3 PUFAs in ratios to n-6 PUFAs of 0.1:1 and 0.5:1 were ingested sequentially for 1 mo each; patient respiratory indexes were assessed after each treatment. Forced vital capacity (FVC), forced expiratory volume for 1 s (FEV1), peak expiratory flow (PEF), and forced expiratory flow 25-75% (FEF 25-75) were measured along with weekly 24-h urinary leukotriene concentrations. With low n-3 PUFA ingestion, methacholine-induced respiratory distress increased. With high n-3 PUFA ingestion, alterations in urinary 5-series leukotriene excretion predicted treatment efficacy. Elevated n-3 PUFA ingestion resulted in a positive methacholine bronchoprovocation dose change in > 40% of the test subjects (responders). The provocative dose to cause a 20% reduction (PD20) in FEV1, FVC, PEF, and FEF25-75 values could not be calculated because of a lack of significant respiratory reduction. Conversely, elevated n-3 PUFA ingestion caused some of the patients (nonresponders) to further lose respiratory capacity. Five-series leukotriene excretion with high n-3 PUFA ingestion was significantly greater for responders than for nonresponders. A urinary ratio of 4-series to 5-series leukotrienes < 1, induced by n-3 PUFA ingestion, may predict respiratory benefit.
authors.affiliation: Nutrition/Department of Family and Consumer Science, University of Wyoming, Laramie 82071, USA. BROUGHTO@UWYO.EDU
authors.forename: K S
authors.initials: KS
authors.lastname: Broughton
authors.forename: C S
authors.initials: CS
authors.lastname: Johnson
authors.forename: B K
authors.initials: BK
authors.lastname: Pace
authors.forename: M
authors.initials: M
authors.lastname: Liebman
authors.forename: K M
authors.initials: KM
authors.lastname: Kleppinger
mesh_terms: D000328:Adult; D001249:Asthma / Q000178:diet therapy* / Q000378:metabolism* / Q000503:physiopathology; D015415:Biomarkers / Q000652:urine; D001985:Bronchial Provocation Tests; D004305:Dose-Response Relationship, Drug; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage / Q000627:therapeutic use*; D005541:Forced Expiratory Volume / Q000187:drug effects / Q000502:physiology; D006801:Humans; D015289:Leukotrienes / Q000378:metabolism* / Q000652:urine; D016210:Methacholine Chloride / Q000494:pharmacology; D011237:Predictive Value of Tests; D012119:Respiration / Q000187:drug effects / Q000502:physiology; D013997:Time Factors; D014797:Vital Capacity / Q000187:drug effects / Q000502:physiology
chemical_list: D015415:Biomarkers; D015525:Fatty Acids, Omega-3; D015289:Leukotrienes; D016210:Methacholine Chloride