title: Doxymycine-cyanoacrylate treatment of recurrent aphthous ulcers.
abstract: OBJECTIVE
  This study addressed the efficacy of singularly applied topical doxymycine in the pain relief treatment of recurrent aphthous stomatitis.
  
  
  METHODS
  Thirty-one patients with recurrent aphthous lesions were examined and divided randomly in two groups. Experimental group (n = 15) received a topical application of doxymycine and controls (n = 16) received calcii gluconase in the same manner. Medications were covered by isobutyl cyanoacrylate (Iso-Dent). Application was made only once during the recurrent aphthous ulcer episode.
  
  
  RESULTS
  Patients recorded their pain level on a visual analog scale for 10 days during healing. Pain decreased more rapidly in the experimental group, and a statistically significant difference (p < 0.05) in the pain intensity was found from the second to the seventh day after application of doxymycine.
  
  
  CONCLUSIONS
  In recurrent aphthous ulcers, singular treatment of topical doxymycine-cyanoacrylate relieves the pain intensity remarkably for 6 days after a 1 day latency period. Topical doxymycine treatment further exerts potential to directly prevent tissue destruction and to indirectly suppress host inflammatory reaction.
authors.affiliation: Institute of Dentistry, University of Oulu, Finland.
authors.forename: L
authors.initials: L
authors.lastname: Ylikontiola
authors.forename: T
authors.initials: T
authors.lastname: Sorsa
authors.forename: R
authors.initials: R
authors.lastname: Häyrinen-Immonen
authors.forename: T
authors.initials: T
authors.lastname: Salo
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage* / Q000627:therapeutic use; D003487:Cyanoacrylates; D004318:Doxycycline / Q000008:administration & dosage* / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005157:Facial Pain / Q000188:drug therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement; D013281:Stomatitis, Aphthous / Q000188:drug therapy*; D014014:Tissue Adhesives
chemical_list: D000900:Anti-Bacterial Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D003487:Cyanoacrylates; D014014:Tissue Adhesives; C061006:isodent; D004318:Doxycycline