title: Thrombotic microangiopathy in renal transplant recipients treated with cyclosporin A.
abstract: Thrombotic microangiopathy is an uncommon but well described complication of renal transplantation. This study is a review of the case records of 18 patients with biopsy proven post transplant thrombotic microangiopathy, without cellular rejection. There was no single characteristic underlying cause of renal failure in native kidneys. Although only two (11%) patients had undergone previous transplantation, 16 (89%) had panel reactive antibodies (PRA). All patients received prophylactic antilymphocyte globulin, a single patient had cyclosporin A (CSA) at the time of transplant and in 16 patients CSA was introduced when graft function was established. On this protocol 16 (89%) patients had early graft function. All patients developed acute renal failure and 16 (89%) required dialysis. Nine (50%) patients developed hematological abnormalities. All patients were treated aggressively with anti-rejection therapy, CSA was temporarily withdrawn, and 2 (11%) patients received plasmapheresis. Seven (39%) patients lost their grafts. Renal function in the remaining patients recovered to serum creatinine levels ranging from 104 mumol/l to 430 mumol/l (1.2 mg% to 4.8 mg%). All patients with surviving grafts had CSA successfully reintroduced. This study indicates that there is an association between patients who develop posttransplant thrombotic microangiopathy after CSA administration and high PRA levels. The condition appears to respond to anti-rejection therapy and stopping CSA in the majority of cases. The safe reintroduction of CSA suggests that endothelial cell damage in the posttransplant period may be multifactorial and not solely due to CSA therapy.
authors.affiliation: Renal Transplant Program, University of Toronto, Ontario, Canada.
authors.forename: R
authors.initials: R
authors.lastname: Zent
authors.forename: A
authors.initials: A
authors.lastname: Katz
authors.forename: S
authors.initials: S
authors.lastname: Quaggin
authors.forename: D
authors.initials: D
authors.lastname: Cattran
authors.forename: J
authors.initials: J
authors.lastname: Wade
authors.forename: C
authors.initials: C
authors.lastname: Cardella
authors.forename: J
authors.initials: J
authors.lastname: Zaltzman
authors.forename: S
authors.initials: S
authors.lastname: Fenton
authors.forename: E
authors.initials: E
authors.lastname: Cole
mesh_terms: D000293:Adolescent; D000328:Adult; D001706:Biopsy; D016572:Cyclosporine / Q000009:adverse effects*; D006801:Humans; D007668:Kidney / Q000098:blood supply / Q000473:pathology*; D016030:Kidney Transplantation; D008833:Microcirculation / Q000473:pathology; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D013927:Thrombosis / Q000139:chemically induced*; D014652:Vascular Diseases / Q000139:chemically induced / Q000473:pathology*
chemical_list: D016572:Cyclosporine