title: Age-related normal uptake of 99mTc-MDP in the lower spine.
abstract: OBJECTIVE
  The uptake of 99mTc-MDP in the lower spine was quantified in connection with ordinary bone scintigraphy.
  
  
  METHODS
  Fifty-seven women and seventy-two men (aged 20-69 y), with no signs of metabolic or malignant disease and no history of back pain or atraumatic fractures, were included in the study.
  
  
  RESULTS
  The women showed an increase in 99mTc-MDP uptake from the age of 20 y to about 45 y with a decrease from the time of menopause. In contrast to women, the uptake in men showed a slight decrease from the age of 20 y to about 50 y and thereafter a more marked decrease was seen. The major difference between men and women is the high premenopausal uptake in the female skeleton.
  
  
  CONCLUSIONS
  An understanding of age-related changes in 99mTc-MDP uptake, which are indices of the skeletal metabolism, is of importance especially in prevention and treatment of osteoporosis, a common disorder in postmenopausal women.
authors.affiliation: Department of Clinical Physiology, Centralsjukhuset, Kristianstad, Sweden.
authors.forename: G M
authors.initials: GM
authors.lastname: Sundkvist
authors.forename: B
authors.initials: B
authors.lastname: Lilja
authors.forename: S
authors.initials: S
authors.lastname: Mattsson
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging / Q000502:physiology*; D001842:Bone and Bones / Q000000981:diagnostic imaging / Q000378:metabolism*; D005260:Female; D015902:Gamma Cameras; D006801:Humans; D008297:Male; D008875:Middle Aged; D017697:Premenopause; D011877:Radionuclide Imaging; D012727:Sex Characteristics; D013131:Spine / Q000000981:diagnostic imaging / Q000254:growth & development / Q000378:metabolism*; D013669:Technetium Tc 99m Medronate / Q000493:pharmacokinetics*
chemical_list: D013669:Technetium Tc 99m Medronate