title: Modeling the interaction between arousal and chemical drive in sleep-disordered breathing.
abstract: We have measured the ventilatory response to acoustically induced arousal in normal subjects and patients with obstructive sleep apnea syndrome (OSAS). The arousal responses are similar in magnitude and time-course over the first 3 breaths, but in OSAS the subsequent response declines much more rapidly. Incorporation of these empirical findings into an existing model of sleep-disordered breathing allows an improved characterization of state-chemoreflex interactions. The shorter time-course of the arousal response in OSAS promotes greater ventilatory and state instability at low-to-intermediate levels of CO2 gain.
authors.affiliation: Biomedical Engineering Department, University of Southern California, Los Angeles 90007, USA.
authors.forename: M C
authors.initials: MC
authors.lastname: Khoo
authors.forename: R B
authors.initials: RB
authors.lastname: Berry
mesh_terms: D000293:Adolescent; D000328:Adult; D001143:Arousal; D004569:Electroencephalography; D004576:Electromyography; D006801:Humans; D008297:Male; D011175:Positive-Pressure Respiration; D012123:Pulmonary Ventilation; D012891:Sleep Apnea Syndromes / Q000175:diagnosis*; D014851:Wakefulness