title: Heliquinomycin, a new inhibitor of DNA helicase, produced by Streptomyces sp. MJ929-SF2 II. Structure determination of heliquinomycin.
abstract: The structure of heliquinomycin which was isolated from the culture broth of Streptomyces sp. MJ929-SF2 was studied by NMR spectroscopies, X-ray crystallographic analysis and degradation experiments. Heliquinomycin is the first member of glycosylated rubromycins and griseorhodins group antibiotics.
authors.affiliation: Institute of Microbial Chemistry, Tokyo, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Chino
authors.forename: K
authors.initials: K
authors.lastname: Nishikawa
authors.forename: T
authors.initials: T
authors.lastname: Tsuchida
authors.forename: R
authors.initials: R
authors.lastname: Sawa
authors.forename: H
authors.initials: H
authors.lastname: Nakamura
authors.forename: K T
authors.initials: KT
authors.lastname: Nakamura
authors.forename: Y
authors.initials: Y
authors.lastname: Muraoka
authors.forename: D
authors.initials: D
authors.lastname: Ikeda
authors.forename: H
authors.initials: H
authors.lastname: Naganawa
authors.forename: T
authors.initials: T
authors.lastname: Sawa
authors.forename: T
authors.initials: T
authors.lastname: Takeuchi
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D016227:Benzoquinones / Q000737:chemistry / Q000494:pharmacology; D018360:Crystallography, X-Ray; D004265:DNA Helicases / Q000037:antagonists & inhibitors*; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D008968:Molecular Conformation; D015394:Molecular Structure; D013141:Spiro Compounds / Q000737:chemistry / Q000494:pharmacology; D013237:Stereoisomerism; D013302:Streptomyces / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D016227:Benzoquinones; D004791:Enzyme Inhibitors; D013141:Spiro Compounds; C101772:heliquinomycin; D004265:DNA Helicases