title: Cis/carboplatin + vinorelbine +/- radiotherapy in stage III and IV non small cell lung carcinoma.
abstract: The aim of this study was the retrospective evaluation of the effectiveness of cis/carboplatin + vinorelbine +/- radiotherapy in 118 patients with advanced non small cell lung carcinoma (NSCLC). To evaluate the response, pts were divided into three groups: a) Stage III pts. who received both chemotherapy and radiotherapy treatment (RC + RP = 43.75%, median survival 16.25 months); b) Stage III pts. who underwent only CT because RT was contraindicated (RC + RP = 21.95%, median survival 12.7 months); c) Stage II pts treated with CT alone (RC + RP = 20%, median survival = 12.1 months). Toxicity was mild. The results of the present study, both in terms of response rate and survival, confirm the effectiveness of the combination cis/carboplatin + vinorelbine +/- radiotherapy as palliative treatment of advanced NSCLC.
authors.affiliation: Oncology and Chemotherapy Dept., Fatebenefratelli and Oftalmico Hospital, Milan, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Tomirotti
authors.forename: B
authors.initials: B
authors.lastname: Galassi
authors.forename: M
authors.initials: M
authors.lastname: Dambrosio
authors.forename: V
authors.initials: V
authors.lastname: Fossati
authors.forename: G
authors.initials: G
authors.lastname: Gramegna
authors.forename: F
authors.initials: F
authors.lastname: Colombo
authors.forename: R
authors.initials: R
authors.lastname: Rovej
authors.forename: A
authors.initials: A
authors.lastname: Scanni
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D016190:Carboplatin / Q000008:administration & dosage; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy*; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D012189:Retrospective Studies; D014747:Vinblastine / Q000008:administration & dosage / Q000031:analogs & derivatives; D000077235:Vinorelbine
chemical_list: D014747:Vinblastine; D016190:Carboplatin; D002945:Cisplatin; D000077235:Vinorelbine