Interaction of fiber and energy registration in experimental colon carcinogens.
Male, F344 rats were fed ad libitum diets in which the fiber was either 10% wheat bran or 4% cellulose. The diets contained equivalent amounts of fiber. Other groups were fed wheat bran or cellulose-containing diets which were pair fed to the controls to provide 10, 20, or 30% energy restriction (ER). Colon cancer was induced by five weekly feedings of DMH. After 28 weeks, colon tumor incidence in the ad libitum fed groups was: cellulose 70%, wheat bran 42%. At 10, 20, or 30% ER tumor incidence was 46, 29, and 21% in rats fed cellulose and 17, 17, and 21% in those fed wheat bran, respectively. The data confirm the greater protective action of wheat bran compared to cellulose.
Kritchevsky
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The Wistar Institute, Philadelphia, PA 19104, USA.
Klurfeld
D M
DM
D019813:1,2-Dimethylhydrazine; D000236:Adenoma / Q000473:pathology / Q000517:prevention & control; D000818:Animals; D002273:Carcinogens; D003110:Colonic Neoplasms / Q000139:chemically induced / Q000473:pathology* / Q000517:prevention & control*; D004043:Dietary Fiber / Q000627:therapeutic use*; D004127:Dimethylhydrazines; D002149:Energy Intake; D008297:Male; D051381:Rats; D011916:Rats, Inbred F344
D002273:Carcinogens; D004043:Dietary Fiber; D004127:Dimethylhydrazines; D019813:1,2-Dimethylhydrazine