Deleterious effects of prostaglandin E2 in oesophageal carcinogenesis.
Oesophageal carcinoma is a devastating disease with a poor prognosis. This hypothesis shows how prostaglandin E2 exerts carcinogenic effects in the oesophagus. The contribution of prostaglandin E2 is related to other factors that predispose to oesophageal carcinoma. The implication of the hypothesis is that nonsteroidal anti-inflammatory drugs such as aspirin may be useful in the prevention of oesophageal carcinoma.
Morgan
G
G
West Glamorgan Health Authorities, Swansea, UK.
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D002273:Carcinogens; D002294:Carcinoma, Squamous Cell / Q000209:etiology / Q000503:physiopathology* / Q000517:prevention & control; D015232:Dinoprostone / Q000502:physiology*; D004938:Esophageal Neoplasms / Q000209:etiology / Q000503:physiopathology* / Q000517:prevention & control; D004941:Esophagitis / Q000188:drug therapy; D006801:Humans; D008954:Models, Biological
D000894:Anti-Inflammatory Agents, Non-Steroidal; D002273:Carcinogens; D015232:Dinoprostone