Structure-activity relationship in the induction of chromosomal aberrations and spindle disturbances in Chinese hamster epithelial liver cells by regioisomeric phenanthrene quinones.
Four regioisomeric phenanthrene (PH) quinones (Q) were investigated for their ability to induce chromosomal damage and spindle disturbances. PH 1,4-Q and PH 1,2-Q induced structural as well as numerical chromosomal aberrations, whereas the isomers PH 9,10-Q and PH 3,4-Q were virtually inactive in this respect, However, all four compounds enhanced the frequency of c-mitoses.
Turchi
G
G
European Centre for the Validation of Alternative Methods (ECVAM), J.R.C. Environmental Institute, Ispra (Va), Italy.
Glatt
H R
HR
Seidel
A
A
Puliti
A
A
Sbrana
I
I
D000818:Animals; D002460:Cell Line; D002842:Chromatids / Q000187:drug effects; D002869:Chromosome Aberrations; D006224:Cricetinae; D003412:Cricetulus; D004848:Epithelium / Q000187:drug effects; D007536:Isomerism; D008099:Liver / Q000166:cytology / Q000187:drug effects*; D008940:Mitotic Index / Q000187:drug effects; D009153:Mutagens; D010616:Phenanthrenes / Q000633:toxicity*; D008941:Spindle Apparatus / Q000187:drug effects*; D013329:Structure-Activity Relationship
D009153:Mutagens; D010616:Phenanthrenes; C005399:9,10-phenanthrenequinone; C105961:3,4-phenanthrenequinone; C105959:1,4-phenanthrenequinone; C105960:1,2-phenanthrenequinone