title: Reduction of the allergenicity of soybean by treatment with proteases.
abstract: Soybeans were treated with proteases to reduce allergenicity. By immunoblotting with a monoclonal antibody against a major soybean allergen (Gly m Bd 30K), two of eight proteases so far tested were selected to achieve a reduction in allergenicity. Both antigenicity to the monoclonal antibody and allergenicity to the sera from soybean-sensitive patients proved to be markedly reduced by processing with either protease. Thus, soybeans treated with an appropriate protease may possibly be supplied as a hypoallergenic foodstuff for patients.
authors.affiliation: Department of Nutrition, School of Medicine, University of Tokushima, Japan.
authors.forename: R
authors.initials: R
authors.lastname: Yamanishi
authors.forename: H
authors.initials: H
authors.lastname: Tsuji
authors.forename: N
authors.initials: N
authors.lastname: Bando
authors.forename: Y
authors.initials: Y
authors.lastname: Yamada
authors.forename: Y
authors.initials: Y
authors.lastname: Nadaoka
authors.forename: T
authors.initials: T
authors.lastname: Huang
authors.forename: K
authors.initials: K
authors.lastname: Nishikawa
authors.forename: S
authors.initials: S
authors.lastname: Emoto
authors.forename: T
authors.initials: T
authors.lastname: Ogawa
mesh_terms: D000328:Adult; D000485:Allergens / Q000276:immunology*; D052179:Antigens, Plant; D010450:Endopeptidases / Q000494:pharmacology*; D005260:Female; D005512:Food Hypersensitivity / Q000276:immunology; D006801:Humans; D006868:Hydrolysis; D008297:Male; D010940:Plant Proteins / Q000276:immunology*; D030262:Soybean Proteins; D013025:Glycine max / Q000276:immunology*
chemical_list: D000485:Allergens; D052179:Antigens, Plant; C103236:Gly m BD 30K protein, Glycine max; D010940:Plant Proteins; D030262:Soybean Proteins; D010450:Endopeptidases