[Hypertrophic cardiomyopathy complicating a prolonged corticotherapy for hemorrhagic rectocolitis].
BACKGROUND
The cardiac side-effects of corticosteroid therapy are very uncommon.


METHODS
A girl with ulcerative colitis developed at the age of 8 years an acute digestive episode despite prednisolone and total parenteral nutrition. The patient was then given intravenous methylprednisolone (2 mg/kg/d). Polypnea appeared 25 days later while blood pressure remained normal. Echocardiography revealed a cardiac hypertrophy associated with a systolic anterior motion of the mitral valve. Cardiac symptoms and echography findings returned to normal after reduction of corticosteroid therapy and its administration via the oral route.


CONCLUSIONS
Hypertrophic cardiomyopathy has been described in preterms treated with dexamethasone for bronchopulmonary dysplasia. It is exceptional in older children under corticosteroid therapy and its mechanism remains unknown.
Lhasbellaoui
F
F
Service de pharmacologie clinique, hôpital Robert-Debré, Paris, France.
Faure
C
C
Magnier
S
S
Guillonneau
M
M
Cézard
J P
JP
Navarro
J
J
Jacqz-Aigrain
E
E
D002312:Cardiomyopathy, Hypertrophic / Q000139:chemically induced*; D002675:Child, Preschool; D003093:Colitis, Ulcerative / Q000188:drug therapy*; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008775:Methylprednisolone / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D011239:Prednisolone / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D011241:Prednisone / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D013997:Time Factors
D005938:Glucocorticoids; D011239:Prednisolone; D011241:Prednisone; D008775:Methylprednisolone
Myocardiopathie hypertrophique compliquant une corticothérapie prolongée pour rectocolite hémorragique.