title: The role of Serratia marcescens in soft contact lens associated ocular infections. A review.
abstract: Serratia marcescens is a Gram negative rod which for a century and a half was considered a harmless saphrophyte. However, medical technology and the use of antibacterial agents have created ecological niches for this bacterium, which is now a medical problem. The bacterium is encountered in connection with contact lens keratitis, often associated with contaminated contact lens solutions. The concentrations of chlorhexidin and thiomersal required in contact lens solution to suppress the bacterium have been proved toxic to the eye. Modern contact lens solutions with biguanids have rapid killing kinetics, while in solutions with polyquaternium S. marcescens can survive in reduced numbers for up to 72 hours. The adherence of a specific isolate of Serratia to hydrogel lenses increased with decreased water content of the lenses. However, there has been no correlation between hydrophobicity markers or hemagglutinins and adherence to contact lenses or urinary tract epithelium. When handling medical plastic devices, such as contact lenses, strictly enforced hygiene remains the most important method to combat environmental bacteria such as Serratia marcescens.
authors.affiliation: Department of Environmental Health and Infectious Diseases Control, Karolinska Hospital, Stockholm, Sweden.
authors.forename: P A
authors.initials: PA
authors.lastname: Parment
mesh_terms: D000818:Animals; D001422:Bacterial Adhesion; D018639:Contact Lens Solutions / Q000009:adverse effects; D003263:Contact Lenses, Hydrophilic / Q000009:adverse effects*; D003315:Cornea / Q000382:microbiology*; D004202:Disinfectants / Q000627:therapeutic use; D004866:Equipment Contamination; D015818:Eye Infections, Bacterial / Q000188:drug therapy / Q000209:etiology*; D006388:Hemagglutinins / Q000378:metabolism; D006801:Humans; D007634:Keratitis / Q000188:drug therapy / Q000382:microbiology*; D016868:Serratia Infections / Q000188:drug therapy / Q000209:etiology*; D012706:Serratia marcescens / Q000502:physiology*
chemical_list: D018639:Contact Lens Solutions; D004202:Disinfectants; D006388:Hemagglutinins