Tumor progression and oxidant-antioxidant status.
We previously reported on a paradoxical oxidant-antioxidant status in breast cancer patients, more so in pre-menopausal than menopausal women. In this study, measurements were performed on 146 patients with various carcinomas. Vitamin E/total cholesterol increased and plasma malondialdehyde decreased with tumor size and progression. To investigate the difference between young pre-menopausal and aged menopausal breast cancer patients, the same measurements were performed in 365 breast cancer patients according to pathology, tumor size and estrogen receptors. The oxidant-antioxidant status varied with these prognosis factors in the same pattern, and was more pronounced in young than aged women.
Gerber
M
M
Groupe d'Epidémiologie Métabolique, INSERM-CRLC, Montpellier, France.
Astre
C
C
Ségala
C
C
Saintot
M
M
Scali
J
J
Simony-Lafontaine
J
J
Grenier
J
J
Pujol
H
H
D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002278:Carcinoma in Situ / Q000097:blood; D018270:Carcinoma, Ductal, Breast / Q000097:blood; D016022:Case-Control Studies; D002784:Cholesterol / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000097:blood*; D008875:Middle Aged; D009369:Neoplasms / Q000097:blood*; D012737:Sex Factors; D014810:Vitamin E / Q000097:blood*
D014810:Vitamin E; D008315:Malondialdehyde; D002784:Cholesterol