Inhibitory effect of ethanolamine plasmalogen on iron- and copper-dependent lipid peroxidation.
The effect of ethanolamine plasmalogen (EtnPm) on lipid peroxidation was investigated in liposomal suspension of egg yolk phosphatidylcholine. EtnPm inhibited iron- and copper-dependent peroxidation in the presence of preformed hydroperoxides, although it was not effective for radical initiator mediated lipid peroxidation. EtnPm resulted in complete binding of iron to liposomal lipids, suggesting that EtnPm exerts its inhibitory effect on lipid peroxidation through inhibiting preformed peroxide decomposition by trapping transition metal ions.
Zommara
M
M
Department of Food Science and Technology, School of Agriculture, Kyushu University, Fukuoka, Japan.
Tachibana
N
N
Mitsui
K
K
Nakatani
N
N
Sakono
M
M
Ikeda
I
I
Imaizumi
K
K
D000975:Antioxidants / Q000494:pharmacology*; D003300:Copper / Q000378:metabolism*; D005609:Free Radicals / Q000378:metabolism; D066298:In Vitro Techniques; D007501:Iron / Q000378:metabolism*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008081:Liposomes; D010713:Phosphatidylcholines / Q000378:metabolism; D010955:Plasmalogens / Q000494:pharmacology*; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
D000975:Antioxidants; D005609:Free Radicals; D008081:Liposomes; D010713:Phosphatidylcholines; D010955:Plasmalogens; D017392:Thiobarbituric Acid Reactive Substances; C020791:phosphatidal ethanolamines; D003300:Copper; D007501:Iron