Dispersion of ventricular activation and refractoriness in patients with idiopathic dilated cardiomyopathy.
We sought to evaluate the electrophysiologic substrate for ventricular arrhythmias and sudden cardiac death in patients with idiopathic dilated cardiomyopathy. When compared with controls, patients with cardiomyopathy had prolonged activation times, increased dispersion of activation and recovery, and prolonged duration of monophasic action potential recordings at 70%, but not at 90%, of repolarization.
Dinerman
J L
JL
Department of Medicine, The Johns Hopkins Hospital, Baltimore, Maryland, USA.
Berger
R
R
Haigney
M C
MC
Lawrence
J H
JH
Tomaselli
G F
GF
Calkins
H
H
D006328:Cardiac Catheterization; D002304:Cardiac Pacing, Artificial; D002311:Cardiomyopathy, Dilated / Q000175:diagnosis / Q000503:physiopathology*; D004562:Electrocardiography; D004594:Electrophysiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012815:Signal Processing, Computer-Assisted; D013997:Time Factors; D016276:Ventricular Function / Q000502:physiology*