Design of highly potent noncovalent thrombin inhibitors that utilize a novel lipophilic binding pocket in the thrombin active site.
Tucker
T J
TJ
Department of Medicinal Chemistry, Merck Research Laboratories, West Point, Pennsylvania 19486, USA.
Lumma
W C
WC
Mulichak
A M
AM
Chen
Z
Z
Naylor-Olsen
A M
AM
Lewis
S D
SD
Lucas
R
R
Freidinger
R M
RM
Kuo
L C
LC
D001665:Binding Sites; D018360:Crystallography, X-Ray; D003514:Cyclohexylamines / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D004151:Dipeptides / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D015195:Drug Design; D005343:Fibrinolytic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D006860:Hydrogen Bonding; D015394:Molecular Structure; D011485:Protein Binding; D013917:Thrombin / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000378:metabolism
D003514:Cyclohexylamines; D004151:Dipeptides; D005343:Fibrinolytic Agents; D013917:Thrombin