[The morphochemical characteristics of the reaction of the motor structures of the brain to hyper- and hypofunction of the dopaminergic system].
The investigation of protein (aminopeptidase activity, structured proteins) and of mediator metabolism (monoaminoxidase A and B activities, acetylcholine esterase, Ca(2+)-uptake) was carried out in rat brain motor structures. The study was performed during chronic L-DOPA and haloperidol administration that is under the conditions of hyper- and hypofunction of dopaminergic system. Some peculiarities and differences of sensomotor cortex and nucleus caudatus' reactions to the dysfunction of DA system were revealed at the cellular and subcellular levels. The results show the existence of high morpho-biochemical plasticity of brain structures mentioned above.
Gershteĭn
L M
LM
Dovedova
E L
EL
Dobrynina
M T
MT
Sergutina
A V
AV
Rakhmanova
V I
VI
D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects; D002421:Caudate Nucleus / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D015259:Dopamine Agents / Q000494:pharmacology; D018492:Dopamine Antagonists / Q000494:pharmacology; D006220:Haloperidol / Q000494:pharmacology; D006651:Histocytochemistry; D007980:Levodopa / Q000494:pharmacology; D009044:Motor Cortex / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D009474:Neurons / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar; D011954:Receptors, Dopamine / Q000187:drug effects / Q000502:physiology*
D015259:Dopamine Agents; D018492:Dopamine Antagonists; D011954:Receptors, Dopamine; D007980:Levodopa; D006220:Haloperidol
Morfokhimicheskie osobennosti reaktsii dvigatel'nykh struktur mozga na giper- i gipofunktsiiu dofaminergicheskoĭ sistemy.