title: Focal segmental glomerulosclerosis in primates infected with a simian immunodeficiency virus.
abstract: Focal and segmental glomerulosclerosis (FSG) with endothelial tubuloreticular inclusions (TRIs) is the typical lesion of human HIV-associated glomerulopathy. Autopsy studies showed the presence of FSG in 3 of 15 macaques dying 15-120 weeks after experimental infection with a simian immunodeficiency virus (SIVMne). Ultrastructural studies generally revealed numerous endothelial TRIs (also present in normals), mesangial expansion, and evidence of mesangial cell injury. One additional animal had a small-vessel polyarteritis with a proliferative and focally crescentic glomerulonephritis; seven animals had mild, multifocal interstitial nephritis. All animals had documented viremia after infection; 14 of 15 developed antibodies to SIV postinoculation. Additional postmortem findings included severe enterocolitis, encephalitis, and opportunistic infections. In contrast, autopsy studies of macaques infected with a type D simian retrovirus (SAIDS-D/Washington, SRV-2) for similar periods of time (n = 40) showed no evidence of FSG. One SRV-infected animal had a mild proliferative glomerulonephritis. These studies indicate SIV-infected primates may provide a relevant model for study of human HIV-associated nephropathy. They also indicate the variable pathology that can be seen in primate infections of distinct retrovirus types, each of which produces a simian immunodeficiency state that resembles human AIDS.
authors.affiliation: Department of Pathology, School of Medicine, University of Washington, Seattle 98195, USA.
authors.forename: C E
authors.initials: CE
authors.lastname: Alpers
authors.forename: C C
authors.initials: CC
authors.lastname: Tsai
authors.forename: K L
authors.initials: KL
authors.lastname: Hudkins
authors.forename: Y
authors.initials: Y
authors.lastname: Cui
authors.forename: L
authors.initials: L
authors.lastname: Kuller
authors.forename: R E
authors.initials: RE
authors.lastname: Benveniste
authors.forename: J M
authors.initials: JM
authors.lastname: Ward
authors.forename: W R
authors.initials: WR
authors.lastname: Morton
mesh_terms: D016263:AIDS-Associated Nephropathy; D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D018791:CD4 Lymphocyte Count; D004195:Disease Models, Animal; D004727:Endothelium / Q000821:virology; D015432:Glomerulonephritis, Membranoproliferative / Q000473:pathology / Q000821:virology; D005923:Glomerulosclerosis, Focal Segmental / Q000473:pathology* / Q000821:virology; D006801:Humans; D007668:Kidney / Q000473:pathology* / Q000821:virology; D008251:Macaca; D009395:Nephritis, Interstitial / Q000473:pathology / Q000821:virology; D010488:Polyarteritis Nodosa / Q000473:pathology / Q000821:virology; D012333:RNA, Messenger / Q000032:analysis; D012367:RNA, Viral / Q000032:analysis; D015301:Retroviruses, Simian; D016097:Simian Acquired Immunodeficiency Syndrome / Q000276:immunology / Q000473:pathology* / Q000821:virology; D015302:Simian Immunodeficiency Virus / Q000276:immunology / Q000302:isolation & purification
chemical_list: D000914:Antibodies, Viral; D012333:RNA, Messenger; D012367:RNA, Viral