title: [Course of ischemic risk in treated atheromatous hypertensive patients. The PRIHAM study (Prognosis of Ischemic Risk in Atheromatous Patients under Mediatensyl)].
abstract: Hypertension is one of the major cardiovascular risk factors. However it seldom occurs alone in a patient and the antihypertensive treatment should be taken into account when assessing global cardiovascular status. The PRIHAM study was an open study which enrolled 3,216 hypertensive atheromatous patients who already has had a clinical ischaemic accident. Patients were followed-up for 3 years. The lowering effect on cardiovascular risk, starting from the fifteenth month was confirmed to the end of 36-month study. The effect on blood pressure was observed from the third month. Stabilized blood pressure observed within the first year persisted throughout the three years without tachyphylaxis. It was effective on SBP (-14.4%) and on DBP (-15%) while maintaining a stable heart rate both in the supine position or immediately upon standing or after 3 minutes in the standing position. Tolerance was globally judged as good or very good by the investigating practitioners and the patients expressed an improvement in their feeling of well-being. In conclusion, from the level of effectiveness obtained and the low incidence of adverse effects, urapidil appears well adapted and easy to manage in a population with a particularly high cardiovascular risk.
authors.affiliation: Service de Médecine Interne, CH Pitié-Salpêtrière, Paris.
authors.forename: P
authors.initials: P
authors.lastname: Godeau
authors.forename: F A
authors.initials: FA
authors.lastname: Allaert
authors.forename: J
authors.initials: J
authors.lastname: Barrier
authors.forename: O
authors.initials: O
authors.lastname: Blétry
authors.forename: B
authors.initials: B
authors.lastname: Chamontin
authors.forename: B
authors.initials: B
authors.lastname: Devulder
authors.forename: M
authors.initials: M
authors.lastname: Godin
authors.forename: L
authors.initials: L
authors.lastname: Guillevin
authors.forename: J L
authors.initials: JL
authors.lastname: Guilmot
authors.forename: R
authors.initials: R
authors.lastname: Luccioni
authors.forename: J
authors.initials: J
authors.lastname: Ninet
authors.forename: J M
authors.initials: JM
authors.lastname: Serise
authors.forename: F M
authors.initials: FM
authors.lastname: Zannad
mesh_terms: D000328:Adult; D000368:Aged; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001161:Arteriosclerosis / Q000150:complications / Q000188:drug therapy*; D004341:Drug Evaluation; D004562:Electrocardiography; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy*; D007511:Ischemia / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control*; D008297:Male; D008875:Middle Aged; D010879:Piperazines / Q000627:therapeutic use*; D012307:Risk Factors; D013997:Time Factors
chemical_list: D000959:Antihypertensive Agents; D010879:Piperazines; C015568:urapidil
vernacular_title: Etude de l'évolution du risque ischémique de l'hypertendu athéromateux traité. Etude PRIHAM (Pronostic du Risque Ischémique de l'Hypertendu Athéromateux sous Mediatensyl.