Transition-metal saccharide chemistry and biology: saccharide complexes of Cu(II) and their effect on in vivo metallothionein synthesis in mice.
Monosaccharide (D-Glc, D-Fru, D-Gal, D-Xyl, D-Rib) and disaccharide (Mal) complexes of Cu(II) were synthesized from two different precursors, viz. [NEt4]2 [CuCl2Br2] and CuCl2.2H2O, in nonaqueous media, and isolated in the solid state. The complexes were found to be primarily dimeric and trimeric and water soluble. These were characterized by diffuse reflectance, aqueous solution absorption, CD, FTIR, magnetic susceptibility, EPR, EXAFS, XANES, and elemental analysis. Aqueous solution stability in the pH range 4-8 was studied by cyclic voltammetry and absorption spectroscopy. The effect of subcutaneously injected Cu-Fru, Cu-Xyl, and Cu-Rib complexes on the in vivo metallothionein synthesis in mice was found to be significant in liver, but not in brain, in accordance with the observed copper accumulation in these tissues.
Bandwar
R P
RP
Department of Chemistry, Indian Institute of Technology, Bombay, India.
Rao
C P
CP
Giralt
M
M
Hidalgo
J
J
Kulkarni
G U
GU
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D002942:Circular Dichroism; D003300:Copper / Q000737:chemistry* / Q000494:pharmacology*; D004187:Disaccharides / Q000737:chemistry* / Q000494:pharmacology*; D004355:Drug Stability; D004578:Electron Spin Resonance Spectroscopy; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008668:Metallothionein / Q000096:biosynthesis*; D051379:Mice; D009005:Monosaccharides / Q000737:chemistry* / Q000494:pharmacology*; D009942:Organometallic Compounds / Q000737:chemistry / Q000494:pharmacology; D012996:Solutions; D013053:Spectrophotometry; D017550:Spectroscopy, Fourier Transform Infrared
D004187:Disaccharides; D009005:Monosaccharides; D009942:Organometallic Compounds; D012996:Solutions; D003300:Copper; D008668:Metallothionein