Vitamin C inhibits random migration of malignant pleural effusion mononuclear cells.
Although many epidemiological studies indicate protective effect of vitamin C against a variety of human malignancies its mechanism(s) of action is questionable. The presented results show that the part of its effect may be accomplished by mononuclear cells, as necessary participants in body defence. Namely, in a long-term in vitro assay we tested vitamin C influence on random migration ability of malignant pleural effusion mononuclears (PEM) obtained from breast cancer patients. Vitamin C in a dose- (50-500 micrograms) and time-dependent (4-44 h) manner inhibited PEM motility, suggesting that immobilization of cells in situ may contribute to its beneficial effect in human cancers.
Prokić
L
L
Institute of Physiology, Medical Faculty, Belgrade, Yugoslavia.
Vilić
I
I
Vucković-Dekić
L
L
Nesković-Konstatinović
Z
Z
Susnjar
S
S
D001205:Ascorbic Acid / Q000494:pharmacology*; D001943:Breast Neoplasms / Q000188:drug therapy / Q000276:immunology; D002277:Carcinoma / Q000188:drug therapy / Q000276:immunology / Q000556:secondary; D002464:Cell Migration Inhibition; D002465:Cell Movement / Q000187:drug effects* / Q000276:immunology; D005260:Female; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000187:drug effects* / Q000276:immunology; D016066:Pleural Effusion, Malignant / Q000188:drug therapy* / Q000276:immunology* / Q000473:pathology; D010997:Pleural Neoplasms / Q000188:drug therapy / Q000276:immunology / Q000556:secondary
D001205:Ascorbic Acid