title: Is pregnancy smoking causal to testis cancer in sons? A hypothesis.
abstract: Inquiry studies into smoking during pregnancy as a possible cause of testis cancer in sons are found misinterpreted as purely negative. Danish quinquennial incidence rates for patients aged 25-39 years are compared with rates for tobacco-induced neoplasms among the corresponding maternal generation, primarily of bladder tumours including papillomas, and of lung both for ages 50-64 years, allowing for period of latency. Corresponding to a delay of increase, earlier demonstrated for incidence rates of testis cancer among men born 1939-1945, delays of increase are found for female bladder and lung with allowance for lag-times of 30 and 20 years respectively. Comparison of data from Scandinavian nationwide cancer registries show a noteworthy parallelism of trends from first to last plotting of testis/female bladder ratios. The rise for lung is found steeper in consequence of age distribution.
authors.affiliation: Danish Cancer Registry, Copenhagen.
authors.forename: J
authors.initials: J
authors.lastname: Clemmesen
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D015994:Incidence; D008175:Lung Neoplasms / Q000453:epidemiology / Q000209:etiology; D008297:Male; D008875:Middle Aged; D011247:Pregnancy; D011248:Pregnancy Complications; D012042:Registries; D012306:Risk; D012537:Scandinavian and Nordic Countries / Q000453:epidemiology; D012907:Smoking / Q000009:adverse effects*; D013736:Testicular Neoplasms / Q000453:epidemiology* / Q000209:etiology*; D001749:Urinary Bladder Neoplasms / Q000453:epidemiology / Q000209:etiology