title: Assessment of fibromyxoma cell proliferation in a tench (Tinca tinca L.) by the silver staining nucleolar organizer region (AgNOR) technique.
abstract: A previously described fibromyxoma in a tench was examined for AgNOR proteins and mitotic index to evaluate the cell proliferation of the different tissue areas forming the tumorous mass. The different areas were: myxoid (myxoid cells in a mucous ground substance with few reticular fibres), collagenous (fibroblast-like cells and collagenous fibres) and mixed areas (intermediate cytological and histological features). A significant (P < 0.01) difference in cell proliferative activity between the three different areas was found by the AgNOR technique and confirmed by the mitotic index. The myxoid areas appeared to be the true proliferative compartment of the tumour, whereas the collagenous areas probably played a structural role, related to low cellular proliferative activity. The AgNOR technique appeared to be a convenient method for the rapid evaluation of cell proliferation in fish tissues.
authors.affiliation: Dipartimento di Sanità Pubblica Veterinaria e Patologia Animale, Facoltà di Medicina Veterinaria, Università degli Studi di Bologna, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Manera
authors.forename: R
authors.initials: R
authors.lastname: Preziosi
authors.forename: S
authors.initials: S
authors.lastname: Biavati
mesh_terms: D000818:Animals; D002455:Cell Division; D003530:Cyprinidae; D005350:Fibroma / Q000473:pathology* / Q000662:veterinary*; D008940:Mitotic Index; D009697:Nucleolus Organizer Region / Q000473:pathology*; D016622:Silver Staining / Q000662:veterinary*; D012983:Soft Tissue Neoplasms / Q000473:pathology* / Q000662:veterinary*