[Early postoperative infections after liver transplantation--pathogen spectrum and risk factors].
Infections occurring during the early postoperative phase after liver transplantation result in a significant rise in morbidity and mortality. The records of 279 orthoptic transplantations performed in 248 patients were analyzed retrospectively. 55.6% of all patients suffered from one or more episodes of bacterial and/or fungal infection during their postoperative hospitalisation. The median onset of bacterial/fungal infection was on day 7 after transplantation. Enterococci (42 episodes), Pseudomonas aeruginosa (38 episodes), staphylococci (37 episodes), Escherichia coli (17 episodes) and Candida albicans (11 episodes) were the most frequently detected organisms. 74 (29.8%) patients developed viral infections. 20 patients (8.1%) showed infection with cytomegalovirus (CMV), 32 patients (12.9%) with herpes simplex virus (HSV) and 6 patients (2.4%) with varicella zoster virus (VZV). 14 patients (5.6%) developed infection with both CMV and VZV. Triple infection with CMV, HSV and VZV occurred in one patient. Statistical analysis of potential risk factors showed a significant influence of blood volume replacement (p < 0.001) and occurrence of at least one rejection period (p < 0.02) for major bacterial/fungal infection and immunosuppression (p < 0.001), cold ischemic time (p < 0.04), occurrence of at least one rejection period (p < 0.005) and blood volume replacement (p < 0.04) for viral infection.
Götzinger
P
P
Abteilung für Transplantationschirurgie, Universitätsklinik für Chirurgie, AKH Wien.
Sautner
T
T
Wamser
P
P
Gebhard
B
B
Barlan
M
M
Steininger
R
R
Függer
R
R
Mühlbacher
F
F
D000293:Adolescent; D000328:Adult; D000368:Aged; D001424:Bacterial Infections / Q000175:diagnosis / Q000209:etiology; D002177:Candidiasis / Q000175:diagnosis / Q000209:etiology; D003428:Cross Infection / Q000175:diagnosis / Q000209:etiology*; D005260:Female; D006084:Graft Rejection / Q000175:diagnosis / Q000209:etiology; D006801:Humans; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D009894:Opportunistic Infections / Q000175:diagnosis / Q000209:etiology*; D012307:Risk Factors; D013530:Surgical Wound Infection / Q000175:diagnosis / Q000209:etiology*; D014777:Virus Diseases / Q000175:diagnosis / Q000209:etiology
Frühe postoperative Infektionen nach Lebertransplantation--Keimspektrum und Risikofaktoren.