Clinical significance of IgG Fc receptors and Fc gamma R-directed immunotherapies.
Fc receptors for IgG (Fc gamma Rs) can trigger the inflammatory, cytotoxic and hypersensitivity functions of immune effector cells. Activation or deactivation of effector cells via Fc gamma Rs can be exploited to develop novel therapies for cancer, infectious diseases and autoimmune disorders. Initial results of clinical trials for several Fc gamma R-directed immunotherapies show the potential promise of this approach.
Deo
Y M
YM
Medarex Inc., Annandale, NJ 08801, USA. YashDeo@injersey.com
Graziano
R F
RF
Repp
R
R
van de Winkel
J G
JG
D000818:Animals; D018033:Antibodies, Bispecific / Q000627:therapeutic use; D001327:Autoimmune Diseases / Q000276:immunology / Q000628:therapy; D003141:Communicable Diseases / Q000276:immunology / Q000628:therapy; D006801:Humans; D007167:Immunotherapy; D009369:Neoplasms / Q000276:immunology / Q000628:therapy; D017452:Receptors, IgG / Q000737:chemistry / Q000276:immunology
D018033:Antibodies, Bispecific; D017452:Receptors, IgG