title: Clinical analgesic equivalence for morphine and hydromorphone with prolonged PCA.
abstract: A morphine to hydromorphone equivalence ratio of 7:1 has become the accepted standard, but evidence supporting it comes from single dose studies performed before the advent of patient controlled analgesia (PCA). We compared morphine and hydromorphone use with PCA in bone marrow transplantation patients who required opioids for the control of severe oral mucositis over several days or weeks. An exploratory analysis of clinical records from 102 patients (981 patient days) who used PCA opioids for varying periods of up to 50 days suggested a morphine to hydromorphone use ratio of 3:1. To clarify this observation, we studied a subset of patients under matched conditions. During a 7 day window in which mean oral mucositis severity did not vary across drug use groups and pain scores did not vary over time, patients in both groups gave equal pain relief satisfaction scores. Thirty-six patients who used morphine and 21 who used hydromorphone contributed data on pain, satisfaction with pain control, and drug consumption. We observed an average morphine/hydromorphone ratio of 3:1. This differs markedly from historical single dose studies used in published dose equivalency recommendations implying that other equivalency ratios in clinical use may be inappropriate.
authors.affiliation: Pain and Toxicity Research Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98104, USA.
authors.forename: P J
authors.initials: PJ
authors.lastname: Dunbar
authors.forename: C R
authors.initials: CR
authors.lastname: Chapman
authors.forename: F P
authors.initials: FP
authors.lastname: Buckley
authors.forename: J R
authors.initials: JR
authors.lastname: Gavrin
mesh_terms: D000328:Adult; D016058:Analgesia, Patient-Controlled; D000701:Analgesics, Opioid / Q000493:pharmacokinetics*; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D004091:Hydromorphone / Q000493:pharmacokinetics*; D008297:Male; D009020:Morphine / Q000493:pharmacokinetics*; D009061:Mouth Mucosa; D010146:Pain / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D010147:Pain Measurement; D011446:Prospective Studies; D013280:Stomatitis / Q000150:complications / Q000378:metabolism; D013810:Therapeutic Equivalency
chemical_list: D000701:Analgesics, Opioid; D009020:Morphine; D004091:Hydromorphone