Consciousness in waking and dreaming: the roles of neuronal oscillation and neuromodulation in determining similarities and differences.
State-dependent aspects of consciousness are explored with particular attention to waking and dreaming. First, those phenomenological differences between waking and dreaming that have been established through subjective reports are reviewed. These differences are robustly expressed in most aspects of consciousness including perception, attention, memory, emotion, orientation, and thought. Next, the roles of high frequency neuronal oscillation and neuromodulation are explored in waking and rapid eye movement sleep, the stage of sleep with which the most intense dreaming is associated. The high frequency neuronal oscillations serve similar functions in the wake and rapid eye movement states sleep but neuromodulation is very different in the two states. The collective high frequency oscillatory activity gives coherence to spatially separate neurons but, because of the different neuromodulation, the binding of sensory input in the wake state is very different from the binding of internally perceived input during rapid eye movement sleep. An explanatory model is presented which states that neuromodulation, as well as input source and brain activation level differentiate states of the brain, while the self-organized collective neuronal oscillations unify consciousness via long range correlations.
Kahn
D
D
Department of Psychiatry, Harvard Medical School, Boston, MA 02115, U.S.A.
Pace-Schott
E F
EF
Hobson
J A
JA
D003243:Consciousness / Q000502:physiology*; D004325:Dreams / Q000502:physiology*; D004569:Electroencephalography; D006801:Humans; D009474:Neurons / Q000502:physiology*; D012895:Sleep, REM / Q000502:physiology; D014851:Wakefulness / Q000502:physiology*