Relationship between gallbladder bile concentration and motility in conscious dogs: role of cholecystokinin.
The relationship between gallbladder (GB) bile concentration and motility was studied in conscious dogs. The 12-h GB bile concentrations between meals could be divided into three periods: diluting, minimum, and concentrating periods. During the diluting period, inhibition of GB contractions by a CCKA receptor antagonist, atropine or hexamethonium, resulted in concentration of GB bile, whereas during the concentrating period, CCK-8 shifted the concentration process back to dilution. The GB appears to absorb water continuously from GB bile, which is not regulated by cholinergic or CCKA receptors. The postprandial progressive dilution of GB bile is brought about by GB pumping controlled by cholecystokinin (CCK).
Muramatsu
S
S
Gastrointestinal Research Laboratory, Gumma University, Maebashi, Japan.
Sonobe
K
K
Mizumoto
A
A
Yamada
T
T
Itoh
Z
Z
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D001570:Benzodiazepinones / Q000494:pharmacology; D001646:Bile / Q000378:metabolism*; D001663:Bilirubin / Q000378:metabolism; D002766:Cholecystokinin / Q000502:physiology*; D020109:Devazepide; D004285:Dogs; D004386:Duodenum / Q000187:drug effects; D005502:Food; D005704:Gallbladder / Q000187:drug effects / Q000502:physiology*; D005769:Gastrointestinal Motility; D018738:Hexamethonium / Q000494:pharmacology; D006727:Hormone Antagonists / Q000494:pharmacology; D011706:Pyloric Antrum / Q000187:drug effects; D043886:Receptor, Cholecystokinin A; D011949:Receptors, Cholecystokinin / Q000037:antagonists & inhibitors*; D012844:Sincalide / Q000494:pharmacology*; D012964:Sodium / Q000378:metabolism
D001570:Benzodiazepinones; D006727:Hormone Antagonists; D043886:Receptor, Cholecystokinin A; D011949:Receptors, Cholecystokinin; D018738:Hexamethonium; D001285:Atropine; D002766:Cholecystokinin; D012964:Sodium; D020109:Devazepide; D012844:Sincalide; D001663:Bilirubin