title: Systemic and hepatic hemodynamic changes in acute liver injury.
abstract: Systemic and hepatic circulatory changes were studied in rats over the course of acute liver injury. Hepatic injury was induced by intraperitoneal injection of D-galactosamine (1.1 g/kg), and systemic and hepatic hemodynamics were measured over a 72-h period using a radioactive microsphere technique with direct measurement of arterial, portal venous, and hepatic venous blood oxygen content. Cardiac output increased to a maximum at 48 h, producing a marked increase (450%) in hepatic arterial blood flow so that it became the dominant supply of oxygen at the time of maximal hepatic injury. A subsequent increase in portal venous flow resulted in an overall increase in total hepatic blood flow of 500%. At this point the oxygen delivery by the hepatic arterial and portal venous systems was equal. These circulatory changes returned to control values by 72 h with recovery of liver function. These results demonstrate the development of a hyperdynamic circulation and a marked change in the normal relationship between portal venous and hepatic arterial blood flows that occur during hepatic injury.
authors.affiliation: Institute of Liver Studies, King's College School of Medicine and Dentistry, London, UK.
authors.forename: A J
authors.initials: AJ
authors.lastname: Makin
authors.forename: R D
authors.initials: RD
authors.lastname: Hughes
authors.forename: R
authors.initials: R
authors.lastname: Williams
mesh_terms: D000208:Acute Disease; D000818:Animals; D001794:Blood Pressure; D001835:Body Weight; D002302:Cardiac Output; D005688:Galactosamine / Q000633:toxicity; D005690:Galactose / Q000378:metabolism; D006439:Hemodynamics; D006499:Hepatic Artery; D008099:Liver / Q000098:blood supply / Q000293:injuries* / Q000378:metabolism; D008102:Liver Circulation; D010100:Oxygen / Q000097:blood; D010101:Oxygen Consumption; D011169:Portal Vein; D051381:Rats; D017208:Rats, Wistar; D013152:Splanchnic Circulation; D013997:Time Factors; D014655:Vascular Resistance
chemical_list: D005688:Galactosamine; D010100:Oxygen; D005690:Galactose