Serum level and gene polymorphism of angiotensin I converting enzyme in Japanese children.
The aim of the present study was to determine the distribution of the insertion/deletion polymorphism of angiotensin I converting enzyme (ACE) gene in Japanese children. In addition, the relationship between this polymorphism and serum ACE levels in the same population were analyzed. Insertion/deletion polymorphism located in intron 16 of the ACE gene was examined by polymerase chain reaction in Japanese children aged 10-15 years. Allele frequencies were 0.64 for the insertion allele and 0.36 for the deletion allele in 122 subjects. No association was found between genotypes in this polymorphism and the level of systolic or diastolic blood pressure. A significant relationship between this polymorphism and serum ACE activity was observed. These results suggest that interindividual variability of serum ACE level is strongly influenced by the ACE genotype as early as in childhood.
Yamamoto
K
K
Department of Pediatrics, Niigata University School of Medicine, Japan.
Kataoka
S
S
Hashimoto
N
N
Kakihara
T
T
Tanaka
A
A
Kawasaki
T
T
kikuchi
T
T
Takahashi
H
H
Uchiyama
M
M
D000293:Adolescent; D044466:Asian People / Q000235:genetics*; D002648:Child; D005260:Female; D017353:Gene Deletion; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007564:Japan; D008297:Male; D007703:Peptidyl-Dipeptidase A / Q000097:blood* / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic
D007703:Peptidyl-Dipeptidase A