title: Aberrant expression and function of p53 in T-cells immortalized by HTLV-I Tax1.
abstract: The expression and function of p53 tumor suppressor protein was investigated in T-cells immortalized by the Tax1 protein of HTLV-I. Conformationally wild-type p53 was expressed at elevated levels in Tax1-immortalized T-cells by post-transcriptional mechanisms when compared with normal T-cells. Luciferase assays with a reporter plasmid containing p53-binding sites revealed an impairment in the transactivating function of p53 in Tax1-immortalized T-cells. Our results suggest an important role for Tax1 in the aberrant expression and function of p53 observed in many HTLV-I transformed cells.
authors.affiliation: Virology Division, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Akagi
authors.forename: H
authors.initials: H
authors.lastname: Ono
authors.forename: N
authors.initials: N
authors.lastname: Tsuchida
authors.forename: K
authors.initials: K
authors.lastname: Shimotohno
mesh_terms: D015496:CD4-Positive T-Lymphocytes / Q000378:metabolism*; D002461:Cell Line, Transformed; D002472:Cell Transformation, Viral; D016356:Gene Products, tax / Q000502:physiology*; D015368:Human T-lymphotropic virus 1 / Q000502:physiology*; D006801:Humans; D019169:Jurkat Cells; D015533:Transcriptional Activation; D014162:Transfection; D016159:Tumor Suppressor Protein p53 / Q000096:biosynthesis* / Q000737:chemistry / Q000502:physiology*
chemical_list: D016356:Gene Products, tax; D016159:Tumor Suppressor Protein p53