Adoptive transfer of immunity induced with chloroquine attenuated Plasmodium yoelii nigeriensis from immune to immunologically naive mice.
Immunity was induced in albino mice using Chloroquine-attenuated Plasmodium yoelii nigeriensis which had been maintained under drug pressure in 4 passages. Attempts were made to adoptively transfer immunity from the immune to immunologically naive mice by means of serum, spleen and thoracic duct extracts. None of them conferred complete immunity on the recipients but some protection was gained. This was evident from the prolongation of both the pre-patent periods of the infection and the survival periods of the host mice. The best protection conferred by the different extracts was seen in groups that received 0.4 ml serum, 0.9 ml spleen and 1.2 ml thoracic duct extracts whose survival periods lasted 23, 21 and 15 days respectively as compared to 9 days for the controls.
Kimbi
H K
HK
Department of Medical Microbiology and Parasitology, College of Medicine of the University of Lagos, Nigeria.
Fagbenro-Beyioku
A F
AF
D019264:Adoptive Transfer / Q000379:methods*; D000818:Animals; D000962:Antimalarials; D001769:Blood / Q000276:immunology; D002457:Cell Extracts / Q000276:immunology; D002738:Chloroquine; D004351:Drug Resistance; D051379:Mice; D010967:Plasmodium yoelii / Q000187:drug effects* / Q000276:immunology*; D013154:Spleen / Q000276:immunology; D013897:Thoracic Duct / Q000276:immunology
D000962:Antimalarials; D002457:Cell Extracts; D002738:Chloroquine