title: Dammarane saponins from Zizyphus lotus.
abstract: Four dammarane-type saponins were isolated by means of centrifugal partition chromatography from the root bark of Zizyphus lotus. Their structures were elucidated using a combination of 1D and 2D 1H and 13C NMR spectra and mass spectroscopy. One of these glycosides is the known jujuboside A. The others are three new dammarane saponins, identified as 3-O-beta-D-glucopyranosyl(1-->6)-beta-D-glucopyranosyl (1-->3)-[alpha-L-rhamnopyranosyl(1-->2)]-alpha-L-arabinopyranosyl jujubogenin = jujuboside C, 3-O-alpha-L-rhamnopyranosyl (1-->2)-[beta-D-glucopyranosyl(1-->3)]-beta-D-galactopyranosyl lotogenin = lotoside I, and 3-O-alpha-L-rhamnopyranosyl(1-->2)-[beta-D-glucopyranosyl (1-->3)]-beta-D-glucopyranosyl lotogenin = lotoside II. Lotogenin is a new dammarane derivative identified as (15R, 16R, 20R, 22R)-16 beta, 22-epoxydammar-24-ene-3 beta, 15 alpha, 16 alpha, 20 beta-tetraol.
authors.affiliation: Faculté de Pharmacie (URA au CNRS 492), Reims, France.
authors.forename: J H
authors.initials: JH
authors.lastname: Renault
authors.forename: K
authors.initials: K
authors.lastname: Ghedira
authors.forename: P
authors.initials: P
authors.lastname: Thepenier
authors.forename: C
authors.initials: C
authors.lastname: Lavaud
authors.forename: M
authors.initials: M
authors.lastname: Zeches-Hanrot
authors.forename: L
authors.initials: L
authors.lastname: Le Men-Olivier
mesh_terms: D002240:Carbohydrate Sequence; D009682:Magnetic Resonance Spectroscopy; D008969:Molecular Sequence Data; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013256:Steroids / Q000737:chemistry / Q000302:isolation & purification*; D014315:Triterpenes; D000097669:Dammaranes
chemical_list: D013256:Steroids; D014315:Triterpenes; D000097669:Dammaranes