title: Gene therapy approaches to Parkinson's disease: preclinical to clinical trials, or what steps to take to get there from here?
abstract: Do "gene therapies" offer new approaches to the treatment of Parkinson's disease? The presentations of this symposium, as well as numerous published articles, suggest that they might. This article describes a preclinical in vivo gene therapy study in parkinsonian monkeys and briefly reviews the history of studies with novel cellular implantation approaches to Parkinson's disease as a basis for evaluating when and how gene therapy trials in Parkinson's patients might be appropriate. A number of concerns are raised.
authors.affiliation: Department of Psychiatry, Yale University School of Medicine, Hamden, Connecticut 06517, USA.
authors.forename: D E
authors.initials: DE
authors.lastname: Redmond
mesh_terms: D000818:Animals; D002986:Clinical Trials as Topic; D015316:Genetic Therapy; D006801:Humans; D010300:Parkinson Disease / Q000628:therapy*; D012107:Research Design