title: [Cefpirome--a fourth generation antibiotic for the treatment of severe hospital infections].
abstract: The efficacy of cefpirome was estimated in the treatment of 12 patients with severe hospital infection in the Municipal Hospital No. 7. The positive clinical effect at the background of the cefpirome use was recorded in 11 patients. The eradication of the primary pathogens was stated in 10 patients. 116 isolates were tested for their susceptibility to cefpirome. 92 per cent of the isolates from outpatients and 79 per cent of the isolates from inpatients proved to be susceptible to the antibiotic. The results of the cefpirome use in the treatment of patients with various infections in 6 hospitals of Moscow were analyzed. The positive clinical effect was observed in 103 out of 111 patients (93 per cent). The eradication of the primary pathogens was recorded in 90 out of 102 patients (88 per cent). In the treatment of the lower respiratory tract infection, urinary tract infection and surgical infection the positive clinical results were stated in 91, 95 and 96 per cent of the cases respectively. Insignificant or moderate side effects of the drug were observed in 17 patients. Discontinuation of the drug use because of the side effects was required in 2 of them. The results showed that the use of cefpirome in the monotherapy of various severe hospital infections was efficient and safe.
authors.forename: S V
authors.initials: SV
authors.lastname: Iakovlev
authors.forename: L I
authors.initials: LI
authors.lastname: Dvoretskiĭ
authors.forename: T V
authors.initials: TV
authors.lastname: Shakhova
authors.forename: L V
authors.initials: LV
authors.lastname: Eremina
mesh_terms: D000328:Adult; D002511:Cephalosporins / Q000009:adverse effects / Q000627:therapeutic use*; D003428:Cross Infection / Q000188:drug therapy* / Q000382:microbiology; D006773:Hospitals, Municipal; D006801:Humans; D008826:Microbial Sensitivity Tests; D012426:Russia; D016896:Treatment Outcome; D000097572:Cefpirome
chemical_list: D002511:Cephalosporins; D000097572:Cefpirome