title: [Therapy refractory arterial hypotension after heart operation].
abstract: Adrenalin insufficiency associated with adrenal hemorrhage, is a rare complication after cardiac surgery in neonates. A boy suffering from transposition of the great arteries, who had an arterial switch-operation on day three of his life, acquired a bilateral adrenal hemorrhage. Clinically the situation resembled a septic shock. Despite large doses of catecholamines, he continued to have severe arterial hypotension, anuria, and kyperkalemia. The clinical condition did not change, although sepsis specific therapy was initiated. Consequently adrenal insufficiency, as a possible postoperative complication, was considered and prednisolon, initially in a dose of 15 mg/kg/d, was administered. The clinical condition improved dramatically. The diagnosis could be confirmed by ultrasound examination and determination of cortisol and ACTH plasma levels. Adrenal insufficiency was only transitory, adrenal sonography on day 135 returned to normal. The surgical procedure on heart-lung bypass, the obligatory anticoagulation and the perioperative stress have to be considered as pathogenetic factors.
authors.affiliation: Abteilug für Neonatologie, angeborene Storungen und Intersivmedizin, Universitätsklinik für Kinder- und Jugendheilkunde Wien.
authors.forename: K
authors.initials: K
authors.lastname: Frenzel
authors.forename: G
authors.initials: G
authors.lastname: Burda
authors.forename: G
authors.initials: G
authors.lastname: Fürst
authors.forename: J
authors.initials: J
authors.lastname: Golej
authors.forename: M
authors.initials: M
authors.lastname: Hermon
authors.forename: G
authors.initials: G
authors.lastname: Trittenwein
authors.forename: A
authors.initials: A
authors.lastname: Pollak
mesh_terms: D000309:Adrenal Insufficiency / Q000097:blood / Q000188:drug therapy*; D000324:Adrenocorticotropic Hormone / Q000097:blood; D003937:Diagnosis, Differential; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D006439:Hemodynamics / Q000187:drug effects / Q000502:physiology; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007022:Hypotension / Q000097:blood / Q000188:drug therapy*; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D011183:Postoperative Complications / Q000097:blood / Q000188:drug therapy*; D011239:Prednisolone / Q000008:administration & dosage / Q000031:analogs & derivatives*; D014188:Transposition of Great Vessels / Q000601:surgery*
chemical_list: D000324:Adrenocorticotropic Hormone; D011239:Prednisolone; C021322:prednisolone hemisuccinate; D006854:Hydrocortisone