title: Effects of curvature and stenosis-like narrowing on wall shear stress in a coronary artery model with phasic flow.
abstract: To gain insight into the details of intracoronary flow we have used computational fluid dynamic techniques to determine the velocity and wall shear stress distributions in both steady- and phasic-flow models of a curved coronary artery with several degrees of stenosis. The steady-flow Reynolds number was 500 and the peak phasic flow Reynolds number was 700. Without stenosis and at 25% (area) stenosis wall shear stress and velocities are higher at the outer wall than the inner wall but retain the same direction as the superimposed flow. At higher stenoses laminar flow separation occurs and the inner wall is exposed to shear stresses that vary widely, both temporally and spatially.
authors.affiliation: Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.
authors.forename: V A
authors.initials: VA
authors.lastname: Nosovitsky
authors.forename: O J
authors.initials: OJ
authors.lastname: Ilegbusi
authors.forename: J
authors.initials: J
authors.lastname: Jiang
authors.forename: P H
authors.initials: PH
authors.lastname: Stone
authors.forename: C L
authors.initials: CL
authors.lastname: Feldman
mesh_terms: D001161:Arteriosclerosis / Q000473:pathology* / Q000503:physiopathology*; D001696:Biomechanical Phenomena; D001783:Blood Flow Velocity / Q000502:physiology; D003198:Computer Simulation; D003326:Coronary Circulation / Q000502:physiology; D003331:Coronary Vessels / Q000473:pathology* / Q000503:physiopathology*; D006801:Humans; D008955:Models, Cardiovascular