Effect of C-peptide on insulin and glucagon release by isolated perfused rat pancreas.
Administration of rat C-peptide (0.1 mumol/l) to isolated rat pancrease failed to inhibit insulin release induced by a high concentration of D-glucose (11.1 mmol/l) but prevented the progressive increase in insulin output otherwise observed during prolonged perfusion in the presence of 3.3 mmol/l glucose and 5.0 mmol/l L-arginine. In these experiments, C-peptide failed to affect glucagon output. The findings suggest that in suitable conditions C-peptide can inhibit insulin release.
Leclercq-Meyer
V
V
Laboratory of Experimental Medicine, Brussels Free University, Belgium.
Malaisse
W J
WJ
Johansson
B L
BL
Wahren
J
J
D000818:Animals; D002096:C-Peptide / Q000494:pharmacology*; D005260:Female; D005934:Glucagon / Q000378:metabolism*; D005947:Glucose / Q000494:pharmacology; D066298:In Vitro Techniques; D007328:Insulin / Q000378:metabolism*; D007329:Insulin Antagonists; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000187:drug effects / Q000378:metabolism*; D007700:Kinetics; D010477:Perfusion; D051381:Rats; D017208:Rats, Wistar
D002096:C-Peptide; D007328:Insulin; D007329:Insulin Antagonists; D005934:Glucagon; D005947:Glucose