title: Intraamniotic prostaglandin F2 alpha for pregnancy termination in the second and early third trimesters of pregnancy.
abstract: OBJECTIVE
  To examine the effectiveness and safety of intraamniotic prostaglandin F2 alpha (PGF2 alpha) instillation during second- and early third-trimester termination of pregnancy.
  
  
  METHODS
  The study group consisted of 173 women between 18 and 32 weeks of gestation admitted for termination of pregnancy with a live, singleton fetus. The procedure included intraamniotic instillation of 40 mg PGF2 alpha. In cases of failed induction; after 24 hours an additional procedure (repeated PGF2 alpha injection, oxytocin augmentation or extraovular balloon installation) was performed.
  
  
  RESULTS
  The mean induction-to-abortion interval was 27 +/- 17 hours, 26 minutes. The induction-to-abortion interval was not significantly influenced by parity, maternal age, indication for pregnancy termination or gestational age at the time of the procedure. Complications were related to a longer induction-to-abortion interval (35 hours, 41 minutes +/- 26 hours, 15 minutes in complicated cases as compared to 25 hours, 43 minutes +/- 15 hours, 28 minutes, P = .012). However, complications were uncommon.
  
  
  CONCLUSIONS
  Intraamniotic PGF2 alpha instillation was safely used for termination of pregnancy, even at advanced gestational ages. The induction-to-abortion interval is the main factor influencing complications and is important as a catalyst for cases that fail to abort within 24 hours.
authors.affiliation: Department of Obstetrics and Gynaecology, Chaim Sheba Medical Center, Tel Hashomer, Israel.
authors.forename: S
authors.initials: S
authors.lastname: Lipitz
authors.forename: D
authors.initials: D
authors.lastname: Grisaru
authors.forename: A
authors.initials: A
authors.lastname: Libshiz
authors.forename: Z
authors.initials: Z
authors.lastname: Rotstein
authors.forename: E
authors.initials: E
authors.lastname: Schiff
authors.forename: A
authors.initials: A
authors.lastname: Lidor
authors.forename: R
authors.initials: R
authors.lastname: Achiron
mesh_terms: D000032:Abortion, Therapeutic / Q000379:methods; D000328:Adult; D000650:Amnion; D015237:Dinoprost / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007267:Injections; D010120:Oxytocics / Q000008:administration & dosage*; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D011263:Pregnancy Trimester, Third
chemical_list: D010120:Oxytocics; D015237:Dinoprost