Renal side-effects of long-term lithium treatment.
The beta 2-Mg (beta 2-microglobulin) and GAG (glycosaminogyclan) excretions in 107 patients with bipolar disorder who had been on lithium treatment for 1-15 years were compared with 29 matched psychiatric control patients. 24-h urine volume, urine beta 2-Mg, GAG values were significantly higher, and maximal urinary osmolality was significantly lower in patients on lithium than in controls. No relationship was found between creatinine clearances and duration of illness, duration of lithium treatment and daily lithium dosages. Duration of lithium treatment was not related to the concentrating capacity. The beta 2-Mg excretion rates were significantly higher in patients with manifest polyuria and with severe concentration defect.
Coşkunol
H
H
Department of Psychiatry, Faculty of Medicine, Ege University, Bornova, Izmir, Turkey.
Vahip
S
S
Mees
E D
ED
Başçi
A
A
Bayindir
O
O
Tuğlulaŕ
I
I
D000328:Adult; D001485:Basement Membrane / Q000187:drug effects; D001714:Bipolar Disorder / Q000188:drug therapy* / Q000652:urine; D003404:Creatinine / Q000652:urine; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006025:Glycosaminoglycans / Q000652:urine; D006801:Humans; D007671:Kidney Concentrating Ability / Q000187:drug effects; D007677:Kidney Function Tests; D007678:Kidney Glomerulus / Q000187:drug effects; D007687:Kidney Tubules, Proximal / Q000187:drug effects; D018021:Lithium Chloride / Q000008:administration & dosage / Q000009:adverse effects*; D008134:Long-Term Care; D008297:Male; D008875:Middle Aged; D011141:Polyuria / Q000139:chemically induced* / Q000652:urine; D001613:beta 2-Microglobulin / Q000652:urine
D006025:Glycosaminoglycans; D001613:beta 2-Microglobulin; D003404:Creatinine; D018021:Lithium Chloride