Persistence of cyclopiazonic acid-induced endothelium-dependent vasodilatation in spontaneously hypertensive and streptozotocin-induced diabetic rats.
We recently reported that cyclopiazonic acid (CPA) releases a novel endothelium-derived relaxing factor that is not prostacyclin, nitric oxide or endothelium-derived hyperpolarizing factor in rat mesenteric arterial bed. The acetylcholine-induced vasodilatation of the isolated mesenteric bed in spontaneously hypertensive rats (SHR) was not different from that in Wistar Kyoto rats (WKY), but it was significantly smaller in streptozotocin (STZ)-induced diabetic rats than in age-matched controls. The CPA-induced vasodilatation was not affected in SHR or in STZ-induced diabetic rats. These results suggest that the CPA-induced endothelium-dependent vasodilatation is resistant to the effects of diabetes.
Kamata
K
K
Department of Physiology and Morphology, Hoshi University, Tokyo, Japan.
Hayashi
T
T
Umeda
F
F
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology*; D004730:Endothelium, Vascular / Q000187:drug effects; D006973:Hypertension / Q000188:drug therapy / Q000503:physiopathology*; D007211:Indoles / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D008638:Mesenteric Arteries / Q000187:drug effects / Q000378:metabolism; D009569:Nitric Oxide / Q000378:metabolism; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D013311:Streptozocin / Q000008:administration & dosage / Q000633:toxicity; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use
D007211:Indoles; D014665:Vasodilator Agents; D009569:Nitric Oxide; D013311:Streptozocin; D000242:Cyclic AMP; D000109:Acetylcholine; C000543:cyclopiazonic acid