title: Amyloid precursor protein mRNAs in Alzheimer's disease.
abstract: Hybridization studies of mRNA link genetic with neurochemical and neuropathological approaches to Alzheimer's disease (AD). Here we review the distribution and abundance of amyloid precursor protein mRNAs in normal and AD-afflicted brains. The expression of apolipoprotein E and presenilin mRNAs are also discussed.
authors.affiliation: Department of Psychiatry, University of Oxford. paul.harrison@psychiatry.ox.ac.uk
authors.forename: P J
authors.initials: PJ
authors.lastname: Harrison
authors.forename: W H
authors.initials: WH
authors.lastname: Wighton-Benn
authors.forename: J M
authors.initials: JM
authors.lastname: Heffernan
authors.forename: M W
authors.initials: MW
authors.lastname: Sanders
authors.forename: R C
authors.initials: RC
authors.lastname: Pearson
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism*; D016564:Amyloid beta-Protein Precursor / Q000235:genetics*; D000818:Animals; D001057:Apolipoproteins E / Q000235:genetics; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics; D053764:Presenilin-1; D053766:Presenilin-2; D012333:RNA, Messenger / Q000378:metabolism*; D014018:Tissue Distribution
chemical_list: D016564:Amyloid beta-Protein Precursor; D001057:Apolipoproteins E; D008565:Membrane Proteins; C508853:PSEN1 protein, human; C508861:PSEN2 protein, human; D053764:Presenilin-1; D053766:Presenilin-2; D012333:RNA, Messenger