title: The human erythroid-specific transcription factor EKLF localizes to chromosome 19p13.12-p13.13.
abstract: Erythroid Krüppel-like factor (EKLF) is a trans-acting factor that binds specifically to the beta-globin promoter CACCC box. EKLF is essential for adult erythroid development in mice. We have cloned and sequenced a cDNA encoding the human homologue of this gene, which shares 69% identity with the mEKLF protein. The expression of hEKLF is restricted to fetal liver and adult bone marrow. The genomic locus of hEKLF was mapped to chromosomal band 19p13.12-p13.13, using fluorescence in situ hybridization.
authors.affiliation: Division of Experimental Hematology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
authors.forename: J H
authors.initials: JH
authors.lastname: van Ree
authors.forename: M A
authors.initials: MA
authors.lastname: Roskrow
authors.forename: A M
authors.initials: AM
authors.lastname: Becher
authors.forename: R
authors.initials: R
authors.lastname: McNall
authors.forename: V A
authors.initials: VA
authors.lastname: Valentine
authors.forename: S M
authors.initials: SM
authors.lastname: Jane
authors.forename: J M
authors.initials: JM
authors.lastname: Cunningham
mesh_terms: D000595:Amino Acid Sequence; D002874:Chromosome Mapping; D002888:Chromosomes, Human, Pair 19; D003001:Cloning, Molecular; D018076:DNA, Complementary; D004268:DNA-Binding Proteins / Q000235:genetics*; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D051741:Kruppel-Like Transcription Factors; D008969:Molecular Sequence Data; D017386:Sequence Homology, Amino Acid; D014157:Transcription Factors / Q000235:genetics*
chemical_list: D018076:DNA, Complementary; D004268:DNA-Binding Proteins; D051741:Kruppel-Like Transcription Factors; D014157:Transcription Factors; C080774:erythroid Kruppel-like factor