title: Pulmonary embolism: detection with MR perfusion imaging of lung--a feasibility study.
abstract: OBJECTIVE
  To evaluate the feasibility of magnetic resonance (MR) perfusion imaging in the human lung to help detect perfusion defects distal to suspected pulmonary embolism.
  
  
  METHODS
  Seven patients suspected of having pulmonary embolism first underwent ventilation-perfusion lung scintigraphy followed by MR perfusion imaging with rapid acquisition of two sets of dynamic images in the coronal and transaxial planes. A bolus of 0.05 mmol per kilogram of body weight gadopentetate dimeglumine or gadodiamide was administered. Single images obtained in each section that showed peak signal intensity from the first passage of contrast material were evaluated visually. An analysis of change in signal intensity over time was performed both on a pixel-by-pixel basis and in selected regions of interest.
  
  
  RESULTS
  In the seven patients, a total of 18 regions of lung tissue with perfusion defects were shown on the ventilation-perfusion scans. In 16 of these regions, MR perfusion images showed a reduced peak signal intensity during first passage of the contrast agent. Perfusion defects could be detected in both the coronal and the transaxial planes on MR perfusion images.
  
  
  CONCLUSIONS
  MR perfusion imaging was feasible for detection of perfusion defects distal to a pulmonary embolism.
authors.affiliation: Department of Medicine, University Hospital, Trondheim, Norway.
authors.forename: T
authors.initials: T
authors.lastname: Amundsen
authors.forename: J
authors.initials: J
authors.lastname: Kvaerness
authors.forename: R A
authors.initials: RA
authors.lastname: Jones
authors.forename: A
authors.initials: A
authors.lastname: Waage
authors.forename: L
authors.initials: L
authors.lastname: Bjermer
authors.forename: G
authors.initials: G
authors.lastname: Nilsen
authors.forename: O
authors.initials: O
authors.lastname: Haraldseth
mesh_terms: D000328:Adult; D000368:Aged; D003287:Contrast Media; D004338:Drug Combinations; D005240:Feasibility Studies; D005260:Female; D005682:Gadolinium; D019786:Gadolinium DTPA; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008536:Meglumine; D008875:Middle Aged; D009942:Organometallic Compounds; D004369:Pentetic Acid / Q000031:analogs & derivatives; D011655:Pulmonary Embolism / Q000175:diagnosis* / Q000000981:diagnostic imaging; D011877:Radionuclide Imaging; D014692:Ventilation-Perfusion Ratio
chemical_list: D003287:Contrast Media; D004338:Drug Combinations; D009942:Organometallic Compounds; D008536:Meglumine; D004369:Pentetic Acid; C064925:gadodiamide; D005682:Gadolinium; D019786:Gadolinium DTPA