title: Isolated testicular relapse in an adolescent 5 years following allogeneic bone marrow transplantation for acute myelogenous leukemia.
abstract: A case of isolated testicular relapse occurring 5 years after allogeneic bone marrow transplantation (BMT) for acute myelogenous leukemia (AML) is reported. The patient presented with M4 AML at age 13 and underwent allogeneic BMT in first remission, 5 months after diagnosis. He had no acute graft-versus-host disease (GVHD) but developed mild chronic GVHD 5 months following transplant and received immunosuppressive therapy for the next 2 years. Five years post-transplant he had an isolated testicular relapse that was treated with chemotherapy and testicular radiation. The patient remains in remission 17 months following relapse and more than 15 months following the cessation of therapy.
authors.affiliation: Division of Hematology/Oncology, Children's Hospital, Boston, MA, USA.
authors.forename: L E
authors.initials: LE
authors.lastname: Lehmann
authors.forename: E C
authors.initials: EC
authors.lastname: Guinan
authors.forename: S L
authors.initials: SL
authors.lastname: Halpern
authors.forename: M J
authors.initials: MJ
authors.lastname: Donovan
authors.forename: B E
authors.initials: BE
authors.lastname: Bierer
authors.forename: S K
authors.initials: SK
authors.lastname: Parsons
mesh_terms: D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D016026:Bone Marrow Transplantation; D006801:Humans; D015479:Leukemia, Myelomonocytic, Acute / Q000628:therapy*; D008297:Male; D012008:Recurrence; D013736:Testicular Neoplasms / Q000188:drug therapy / Q000209:etiology* / Q000532:radiotherapy; D013997:Time Factors; D014184:Transplantation, Homologous