title: [Systemic granulomatous reaction in hip prosthesis. Apropos of 2 anatomoclinical cases].
abstract: OBJECTIVE
  The production of particulate wear debris is a recognised complication of joint arthroplasty. Focus was made on local tissue reactions. Systemic distribution of wear debris are less know. We report two new cases of distant granulomatous reaction.
  
  
  METHODS
  The first case concerned a 71-year-old man with lymph node histiocytosis incidentally discovered during the staging of a prostatic carcinoma. The second case concerned a 61-year-old man with a visceral granulomatosis reaction (liver, spleen and lymph node) associated to hepatic ans splenic enlargement.
  
  
  METHODS
  We realised an histological analysis of several tissue specimens for these two patients and for one case an inductively coupled plasma-mass spectrometry technique (ICPMS).
  
  
  RESULTS
  In all specimens we identified a foreign body granulomatous reaction characterized by the presence of particles coming from hip arthroplasty. The ICPMS identified titanium in spleen.
  
  
  CONCLUSIONS
  Distant granulomatous reaction are generally localised in regional lymph nodes and discovered by accident. A systemic granulomatous reaction attributable to wear particles raises the question of long term biocompatibility of prosthetic materials.
  
  
  CONCLUSIONS
  Besides local reaction, it is of utmost importance that physicians involved in prosthetic field take into consideration the possible systemic adverse effect of wear particles from arthroplasty.
authors.affiliation: Service d'Anatomie Pathologique, CHU Nord, Grenoble.
authors.forename: M
authors.initials: M
authors.lastname: Peoc'h
authors.forename: D
authors.initials: D
authors.lastname: Pasquier
authors.forename: V
authors.initials: V
authors.lastname: Ducros
authors.forename: C
authors.initials: C
authors.lastname: Moulin
authors.forename: F
authors.initials: F
authors.lastname: Bost
authors.forename: C
authors.initials: C
authors.lastname: Faure
authors.forename: B
authors.initials: B
authors.lastname: Pasquier
mesh_terms: D000368:Aged; D001672:Biocompatible Materials / Q000009:adverse effects; D005548:Foreign-Body Migration / Q000209:etiology / Q000473:pathology*; D015745:Granuloma, Foreign-Body / Q000209:etiology / Q000473:pathology*; D006622:Hip Prosthesis / Q000009:adverse effects*; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D016348:Osseointegration
chemical_list: D001672:Biocompatible Materials