Leukemogenesis by Moloney murine leukemia virus: a multistep process.
Moloney murine leukemia virus is a prototypical simple retrovirus that has been an extremely useful model for leukemogenesis. Important steps in leukemogenesis include proviral activation of cellular proto-oncogenes, generation of mink cell focus-inducing recombinants, and early (preleukemic) virus-induced changes in hematopoiesis.
Fan
H
H
Dept of Molecular Biology, University of California, Irvine 92717, USA. hyfan@uci.edu
D000818:Animals; D003043:Cocarcinogenesis; D015972:Gene Expression Regulation, Neoplastic; D007942:Leukemia, Experimental / Q000209:etiology*; D051379:Mice; D008908:Mink Cell Focus-Inducing Viruses / Q000235:genetics / Q000472:pathogenicity; D008979:Moloney murine leukemia virus / Q000235:genetics / Q000472:pathogenicity*; D011289:Preleukemia / Q000209:etiology; D011519:Proto-Oncogenes; D011995:Recombination, Genetic; D012192:Retroviridae Infections / Q000209:etiology*; D014412:Tumor Virus Infections / Q000209:etiology*