Neurotrophin-3-like immunoreactivity and Trk C expression in human spinal motoneurones in amyotrophic lateral sclerosis.
We have demonstrated neurotrophin-3 (NT-3)-like immunoreactivity and tyrosine kinase C (Trk C) receptor expression in motoneurones in postmortem amyotrophic lateral sclerosis (ALS) and control human spinal cord sections. We report that NT-3-like immunoreactivity in motoneurones is decreased in ALS when compared to control tissue. Trk C is expressed in low abundance in both control and ALS motoneurones. These findings are of importance in developing therapeutic strategies for ALS.
Duberley
R M
RM
Department of Anatomy and Developmental Biology, Royal Free Hospital School of Medicine, London, UK.
Johnson
I P
IP
Anand
P
P
Leigh
P N
PN
Cairns
N J
NJ
D000368:Aged; D000369:Aged, 80 and over; D000690:Amyotrophic Lateral Sclerosis / Q000378:metabolism*; D005260:Female; D015870:Gene Expression / Q000502:physiology; D006801:Humans; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D008297:Male; D008875:Middle Aged; D009046:Motor Neurons / Q000737:chemistry* / Q000502:physiology; D009414:Nerve Growth Factors / Q000032:analysis / Q000276:immunology*; D020933:Neurotrophin 3; D012333:RNA, Messenger / Q000032:analysis; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics*; D020812:Receptor, trkC; D017475:Receptors, Nerve Growth Factor / Q000235:genetics*; D013116:Spinal Cord / Q000166:cytology*
D009414:Nerve Growth Factors; D020933:Neurotrophin 3; D012333:RNA, Messenger; D017475:Receptors, Nerve Growth Factor; D020794:Receptor Protein-Tyrosine Kinases; D020812:Receptor, trkC