title: [Spontaneous liver rupture after thrombolytic therapy with streptokinase].
abstract: Two months after an osteosynthesis of a Maisonneuve-fracture a 45-year-old patient developed a thrombosis of the deep veins on the side of the fracture. Subsequent to two days of lysis with Streptokinase a rupture of the liver occurred and was treated by hemihepatectomy. A traumatic event or a tumor could be excluded as reason for the rupture. Therefore a rupture of the liver due to the application of Streptokinase has to be assumed.
authors.affiliation: Klinik und Poliklinik für Chirurgie, Rheinischen Friedrich-Wilhelms-Universität, Born.
authors.forename: M
authors.initials: M
authors.lastname: Hinterthaner
authors.forename: M
authors.initials: M
authors.lastname: Kaminski
authors.forename: A
authors.initials: A
authors.lastname: Hirner
authors.forename: H P
authors.initials: HP
authors.lastname: Fischer
mesh_terms: D056486:Chemical and Drug Induced Liver Injury; D017809:Fatal Outcome; D005260:Female; D018409:Foot Injuries / Q000601:surgery*; D005593:Fracture Fixation, Internal; D006801:Humans; D008099:Liver / Q000473:pathology; D008107:Liver Diseases / Q000473:pathology; D008875:Middle Aged; D011183:Postoperative Complications / Q000139:chemically induced* / Q000188:drug therapy / Q000473:pathology; D012422:Rupture, Spontaneous; D013300:Streptokinase / Q000008:administration & dosage / Q000009:adverse effects*; D015912:Thrombolytic Therapy; D013924:Thrombophlebitis / Q000188:drug therapy*
chemical_list: D013300:Streptokinase