Influence of inhomogeneities in muscle tissue on single-fibre action potentials: a model study.
The influence of changes in electrical conductivity, due to the muscle boundary, layers and compartments of intramuscular connective tissue and blood vessels, on computed single-muscle fibre action potentials (SFAPs) in rat hindleg muscle is calculated. The position of the active fibre is varied throughout the muscle. For fibres close to the muscle boundary, peak-to-peak voltages of SFAPs increase by up to a factor of 3 compared with the unbounded situation. For inner fibres, the presence of nearby connective tissue compartments causes an increase of up to 40%. A blood vessel in the neighbourhood of the active fibre leads to a decrease of at most 20%, for recording sites between the active fibre and the blood vessel. For recording sites beyond the blood vessel, peak-to-peak voltages increase by up to 20%.
Rutten
W L
WL
University of Twente, Department of Electrical Engineering, Enschede, The Netherlands. rtn@eltn.utwente.nl
van Veen
B K
BK
Stroeve
S H
SH
Boom
H B
HB
Wallinga
W
W
D000200:Action Potentials; D000818:Animals; D008954:Models, Biological; D018485:Muscle Fibers, Skeletal / Q000502:physiology; D018482:Muscle, Skeletal / Q000033:anatomy & histology / Q000502:physiology*; D051381:Rats