title: Gene targeting: things go better with Cre.
abstract: New technologies are changing the way in which gene targeting experiments are being designed. It is now becoming possible to analyze gene function in defined tissues at specific times during the life of a mouse.
authors.affiliation: The Jackson Laboratory, Bar Harbor, Maine, 04609, USA.
authors.forename: R
authors.initials: R
authors.lastname: Jiang
authors.forename: T
authors.initials: T
authors.lastname: Gridley
mesh_terms: D000818:Animals; D017101:Bacteriophage P1 / Q000201:enzymology / Q000235:genetics; D018014:Gene Transfer Techniques; D017930:Genes, Reporter; D019426:Integrases / Q000096:biosynthesis / Q000378:metabolism*; D051379:Mice; D008822:Mice, Transgenic; D011401:Promoter Regions, Genetic; D016548:Prosencephalon / Q000378:metabolism; D012091:Repetitive Sequences, Nucleic Acid; D014764:Viral Proteins; D001616:beta-Galactosidase / Q000096:biosynthesis
chemical_list: D014764:Viral Proteins; C045073:Cre recombinase; D019426:Integrases; D001616:beta-Galactosidase