Ethanol and polyamine metabolism: physiologic and pathologic implications: a review.
This review summarizes the effects of ethanol on the metabolism of polyamines (putrescine, spermidine, and spermine), which are endogenous polycations required for cell physiology, growth, and differentiation. Polyamines regulate DNA, RNA, and protein syntheses; stabilize ribosomes, membranes, and nucleic acids; and protect the cell against lipid peroxidation. Polyamine biosynthesis and catabolism may change after acute and chronic ethanol treatment, thereby playing a negative or positive role in the ethanol-induced injury on liver, extrahepatic tissues, embryo, and fetus.
Sessa
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Centro di Studio sulla Patologia Cellulare, CNR, Milan, Italy.
Perin
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D000435:Alcoholic Intoxication / Q000503:physiopathology*; D000437:Alcoholism / Q000503:physiopathology*; D000818:Animals; D000431:Ethanol / Q000493:pharmacokinetics* / Q000633:toxicity; D005260:Female; D063647:Fetal Alcohol Spectrum Disorders / Q000503:physiopathology; D006632:Histamine / Q000502:physiology; D006801:Humans; D007231:Infant, Newborn; D008099:Liver / Q000503:physiopathology; D008108:Liver Diseases, Alcoholic / Q000503:physiopathology; D011247:Pregnancy; D011700:Putrescine / Q000378:metabolism*; D013095:Spermidine / Q000378:metabolism*; D013096:Spermine / Q000378:metabolism*
D013096:Spermine; D000431:Ethanol; D006632:Histamine; D013095:Spermidine; D011700:Putrescine