title: Ultrasound tissue characterization of breast biopsy specimens: expanded study.
abstract: Tissue classification by examining sets of ultrasound parameters is an elusive goal. We report analysis of measurements of ultrasound speed, attenuation and backscatter in the range 3 to 8 MHz in breast tissues at 37 C. Statistical discriminant analysis and neural net analysis were employed. Data were acquired from 24 biopsy and 7 mastectomy specimens. Best separation of the classes normal, benign, and malignant occurred in the 18 cases where two tissue classes were present in the same specimen and parameters were corrected for within-patient mean; then 85-90% of cases in test sets were correctly classified. Most errors comprised misclassified benign cases. The neural net was comparable to discriminant analysis and slightly superior in separating normal and malignant classes.
authors.affiliation: Bioengineering Research Laboratory, SRI International, Manlo Park, California 94025, USA.
authors.forename: C L
authors.initials: CL
authors.lastname: Mortensen
authors.forename: P D
authors.initials: PD
authors.lastname: Edmonds
authors.forename: Y
authors.initials: Y
authors.lastname: Gorfu
authors.forename: J R
authors.initials: JR
authors.lastname: Hill
authors.forename: J F
authors.initials: JF
authors.lastname: Jensen
authors.forename: P
authors.initials: P
authors.lastname: Schattner
authors.forename: L A
authors.initials: LA
authors.lastname: Shifrin
authors.forename: A D
authors.initials: AD
authors.lastname: Valdes
authors.forename: S S
authors.initials: SS
authors.lastname: Jeffrey
authors.forename: L J
authors.initials: LJ
authors.lastname: Esserman
mesh_terms: D001940:Breast / Q000473:pathology*; D001943:Breast Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology; D016002:Discriminant Analysis; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D066298:In Vitro Techniques; D016571:Neural Networks, Computer; D012680:Sensitivity and Specificity; D016217:Ultrasonography, Mammary