title: Ras-GTPase activating protein (GAP): a putative effector for Ras.
abstract: One attractive candidate for a Ras effector protein, other than the Raf kinases, is Ras-GAP. Indeed, recent literature suggests that besides the Raf/MAP kinase cascade, additional pathways must be stimulated to elicit a full biological response to Ras. Ras binds the COOH terminal domain of Ras-GAP, while the NH2 terminal domain appears to be essential for triggering downstream signals. Since Ras-GAP itself has no obvious enzymatic function that might explain a role in processes associated with proliferation, differentiation or apoptosis, candidates for downstream Ras-GAP effectors that fulfill this role remain to be identified. The newly found GAP-SH3 domain Binding Protein (G3BP) may be one of these. This review will briefly overview the candidates Ras effectors and discuss the results that position Ras-GAP as a critical effector downstream of Ras.
authors.affiliation: RPR Gene Medicine, CRVA, Vitry/Seine, France.
authors.forename: B
authors.initials: B
authors.lastname: Tocque
authors.forename: I
authors.initials: I
authors.lastname: Delumeau
authors.forename: F
authors.initials: F
authors.lastname: Parker
authors.forename: F
authors.initials: F
authors.lastname: Maurier
authors.forename: M C
authors.initials: MC
authors.lastname: Multon
authors.forename: F
authors.initials: F
authors.lastname: Schweighoffer
mesh_terms: D000818:Animals; D020690:GTPase-Activating Proteins; D006801:Humans; D011506:Proteins / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*; D020703:ras GTPase-Activating Proteins; D018631:ras Proteins / Q000378:metabolism*
chemical_list: D020690:GTPase-Activating Proteins; D011506:Proteins; D020703:ras GTPase-Activating Proteins; D018631:ras Proteins