Feasibility of ion-pair/supercritical fluid extraction of an ionic compound--pseudoephedrine hydrochloride.
The supercritical fluid extraction (SFE) of an ionic compound, pseudoephedrine hydrochloride, from a spiked-sand surface was successfully demonstrated. The effect of carbon dioxide density (CO2), supercritical fluid composition (pure vs. methanol modified), and the addition of a commonly used reversed-phase liquid chromatographic ion-pairing reagent, 1-heptanesulfonic acid, sodium salt, on extraction efficiency was examined. The extraction recoveries of pseudoephedrine hydrochloride with the addition of the ion-pairing reagent from a spiked-sand surface were shown to be statistically greater than the extraction recoveries without the ion-pairing reagent with both pure and methanol-modified carbon dioxide.
Eckard
P R
PR
Virginia Polytechnic Institute and State University, Department of Chemistry, Blacksburg 24061, USA.
Taylor
L T
LT
D002623:Chemistry Techniques, Analytical / Q000379:methods; D004809:Ephedrine / Q000032:analysis* / Q000302:isolation & purification; D005240:Feasibility Studies; D007477:Ions
D007477:Ions; D004809:Ephedrine