First-pass metabolism of ethanol is negligible in rat gastric mucosa.
Controversy exists concerning whether first-pass metabolism of imbibed ethanol occurs in the gastric mucosa or liver. We assessed ethanol metabolism in rat gastric mucosa by determining to what extent intact [14C]ethanol in body water plus hepatic metabolism could account for [14C]ethanol absorbed from the pylorus-ligated stomach. Intact [14C]ethanol in systemic body water accounted for 84 +/- 1.9% of the [14C]ethanol absorbed from the stomach over a 30-min period. Assuming a 15 ml/min hepatic blood flow, the predicted hepatic metabolism of [14C]ethanol over the 30 min of the study was 18% of the dose. The sum of intact [14C]ethanol and predicted hepatic metabolism accounted for 100% of the ethanol absorbed from the stomach. We conclude that negligible metabolism of ethanol occurred in the gastric mucosa.
Levitt
M D
MD
Research Service, Veterans Administration Medical Center, Minneapolis, Minnesota 55417, USA.
Furne
J
J
DeMaster
E
E
D000426:Alcohol Dehydrogenase / Q000502:physiology*; D000818:Animals; D000431:Ethanol / Q000493:pharmacokinetics*; D005753:Gastric Mucosa / Q000378:metabolism*; D008099:Liver / Q000201:enzymology; D008297:Male; D008657:Metabolic Clearance Rate / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley
D000431:Ethanol; D000426:Alcohol Dehydrogenase