Experimental plasmacytomagenesis in mice.
This article discusses some of the mechanistic aspects of plasma cell tumor development. Plasmacytomagenesis, much like other forms of neoplastic development, is a highly complex process that develops in the B cell differentiation lineage. As more is learned about the molecular genetics of multiple myeloma and PCTs in mice, a unifying concept will emerge that possibly can explain the phenotypic differences in the two neoplastic cell processes as variants of a common process.
Potter
M
M
Laboratory of Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
D000818:Animals; D004195:Disease Models, Animal; D051379:Mice; D009101:Multiple Myeloma