title: [Isolated thyroid nodule. Comparative value of cyto-puncture and scintigraphy].
abstract: OBJECTIVE
  Nodular thyroid disease, indicated by the presence of single or multiple nodules within the thyroid gland is a common clinical problem, the main question remains the malignancy. Radionuclide scanning, ultrasonography and fine needle aspiration biopsy have been helpful to distinguish benign from malignant nodules and to select patients for surgery.
  
  
  METHODS
  We performed a prospective study to assess the comparative value of fine needle nonaspiration biopsy and thyroid scinti scan in the management of 412 patients operated for solitary thyroid nodule.
  
  
  RESULTS
  Sensitivity and negative predictive values were the same for both methods, but specificity of cytology was greater than that of thyroid scinti scan (80.53% vs. 10.47%, p < 0.001).
  
  
  CONCLUSIONS
  Thyroid radionuclide scanning remains valuable in the evaluation of a cytological benign solitary thyroid nodule when TSH value is low, in order to distinguish toxic adenoma from cold nodule in Graves' disease.
authors.affiliation: Service d'Endocrinologie, Nutrition, Médicine interne, CHU d'Angers.
authors.forename: M
authors.initials: M
authors.lastname: Duquenne
authors.forename: V
authors.initials: V
authors.lastname: Rohmer
authors.forename: S
authors.initials: S
authors.lastname: Guyetant
authors.forename: G
authors.initials: G
authors.lastname: Becouarn
authors.forename: N
authors.initials: N
authors.lastname: Dion Barbot
authors.forename: J P
authors.initials: JP
authors.lastname: Saint André
authors.forename: J
authors.initials: J
authors.lastname: Ronceray
authors.forename: J C
authors.initials: JC
authors.lastname: Bigorgne
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001707:Biopsy, Needle; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011446:Prospective Studies; D011877:Radionuclide Imaging; D012680:Sensitivity and Specificity; D013964:Thyroid Neoplasms / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000473:pathology; D016606:Thyroid Nodule / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D013972:Thyrotropin / Q000097:blood
chemical_list: D013972:Thyrotropin