Apoptosis: Bcl-2-related proteins get connected.
Bcl-2 family proteins are key intracellular regulators of programmed cell death. Several recent discoveries demonstrate how these proteins interact with the molecular machinery that controls and executes the cell-death programme, and how they can themselves be regulated by extracellular survival signals.
Jacobson
M D
MD
MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London, WC1E 6BT, UK. m.d.jacobson@ucl.ac.uk
D000818:Animals; D017209:Apoptosis; D017173:Caenorhabditis elegans; D029742:Caenorhabditis elegans Proteins; D002135:Calcium-Binding Proteins / Q000502:physiology; D002470:Cell Survival; D003546:Cysteine Endopeptidases / Q000378:metabolism; D015801:Helminth Proteins / Q000502:physiology; D006801:Humans; D008954:Models, Biological; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000502:physiology*; D015398:Signal Transduction
D029742:Caenorhabditis elegans Proteins; D002135:Calcium-Binding Proteins; C089224:Ced-4 protein, C elegans; D015801:Helminth Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D003546:Cysteine Endopeptidases