Fetal plasma lipid peroxide levels in pregnancies complicated by preeclampsia.
Fetal levels of a representative lipid peroxide malondialdehyde (MDA) were measured as an index of oxidative stress in pregnancies complicated by preeclampsia (n = 19) and in normal pregnancy (n = 23). PO2, PCO2 and pH were also measured in umbilical venous blood obtained by cordocentesis. Plasma MDA levels rose an average of 26% above those of normal pregnancy (p < 0.05) and the elevation correlated inversely with umbilical venous PO2 and pH. The results indicate that fetal oxidative stress occurs in preeclampsia before the onset of labor.
Kato
H
H
Department of Obstetrics and Gynecology, Nippon Medical School, Tokyo, Japan.
Yoneyama
Y
Y
Araki
T
T
D000328:Adult; D002245:Carbon Dioxide / Q000097:blood; D005260:Female; D005312:Fetal Blood / Q000378:metabolism*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008054:Lipid Peroxides / Q000097:blood*; D008315:Malondialdehyde / Q000097:blood; D010100:Oxygen / Q000097:blood; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy; D014471:Umbilical Veins
D008054:Lipid Peroxides; D002245:Carbon Dioxide; D008315:Malondialdehyde; D010100:Oxygen