title: Liver cirrhosis: epidemiological aspects in Italy.
abstract: In order to improve our knowledge of the incidence of liver cirrhosis in Italy, we conducted two epidemiological studies. The first study showed that about 15% of asymptomatic subjects with persistent increase in alanine aminotransferase had histological evidence of cirrhosis. In this setting, cirrhosis was associated with viral aetiology in 91.4% of cases. In the second study, which enrolled cirrhosis patients from 13 centres from all regions of the country, viral infections were detected in 82.6% of patients, the large majority of whom, 71.2%, were positive for hepatitis C virus (HCV). Alcohol abuse was present in 8.7% of cases as exclusive aetiological factor. All the patients were classified according to Child-Pugh and were scored as class A in 62.4%, as class B in 23.8% and as class C in 13.8% of cases. The age distribution showed that about 55% of cirrhosis patients were under 60 years of age; 34.3% of them had a Child-Pugh score of class B or C. These data show that HCV infection represents the predominant aetiological factor of cirrhosis in Italy and that cirrhosis can be found frequently in asymptomatic subjects.
authors.affiliation: Department of Infectious and Tropical Diseases, University of Rome La Sapienza, Italy.
authors.forename: C
authors.initials: C
authors.lastname: De Bac
authors.forename: C
authors.initials: C
authors.lastname: Clementi
authors.forename: F
authors.initials: F
authors.lastname: Duca
authors.forename: D
authors.initials: D
authors.lastname: Livoli
authors.forename: G
authors.initials: G
authors.lastname: Poliandri
authors.forename: A
authors.initials: A
authors.lastname: Bozza
authors.forename: A
authors.initials: A
authors.lastname: Osso
authors.forename: S
authors.initials: S
authors.lastname: Martuscelli
authors.forename: C
authors.initials: C
authors.lastname: Pasquazzi
authors.forename: P
authors.initials: P
authors.lastname: Petrucci
authors.forename: C
authors.initials: C
authors.lastname: Furlan
authors.forename: G
authors.initials: G
authors.lastname: Taliani
mesh_terms: D000437:Alcoholism / Q000150:complications; D005260:Female; D016174:Hepacivirus / Q000302:isolation & purification; D006526:Hepatitis C / Q000150:complications; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008103:Liver Cirrhosis / Q000453:epidemiology* / Q000821:virology; D008297:Male