Liposome encapsulated doxorubicin transfer to the pelvic lymph nodes by endoscopic administration into the bladder wall: a preliminary report.
OBJECTIVE
Liposome encapsulated doxorubicin administered to the pelvic lymph nodes might be effective against pelvic node metastasis. We determined whether the drug can be delivered to the nodes via the bladder wall.


METHODS
Ten patients underwent endoscopic administration of 10 mg. liposomal doxorubicin into the bladder wall 3 days before cystectomy. The concentration of doxorubicin in the pelvic lymph nodes obtained at operation was measured.


RESULTS
No complication developed after drug administration. Almost all lymph nodes examined contained more than 100 ng./gm. doxorubicin (median 1,860).


CONCLUSIONS
Endoscopic administration of liposomal doxorubicin into the bladder wall may be an alternative method to deliver doxorubicin to the pelvic lymph nodes.
Tsuruta
T
T
Department of Urology, Shinshu University School of Medicine, Matsumoto, Japan.
Muraishi
O
O
Katsuyama
Y
Y
Murata
Y
Y
Ichino
M
M
Ogawa
A
A
D000368:Aged; D000369:Aged, 80 and over; D004317:Doxorubicin / Q000008:administration & dosage*; D004337:Drug Carriers; D005260:Female; D006801:Humans; D007267:Injections; D008081:Liposomes; D008198:Lymph Nodes; D008297:Male; D008875:Middle Aged; D010388:Pelvis; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy*
D004337:Drug Carriers; D008081:Liposomes; D004317:Doxorubicin