title: Granular cell dermatofibroma.
abstract: We herein describe the histopathologic findings of an otherwise stereotypical dermatofibroma replete with granular cells. The histopathologic diagnosis of dermatofibroma was underlined by immunohistochemical findings and ultrastructural examination. Cellular granularity is the result of cytoplasmic accumulation of lysosomal structures and can be observed not only in conventional granular cell tumor but in a variety of benign and malignant cutaneous neoplasms. Granular cell dermatofibroma represents a hitherto undescribed variant of dermatofibroma that can be added to the broad histopathologic spectrum of this benign fibrohistiocytic proliferation.
authors.affiliation: Department of Dermatology, University of Graz, Austria.
authors.forename: H P
authors.initials: HP
authors.lastname: Soyer
authors.forename: D
authors.initials: D
authors.lastname: Metze
authors.forename: H
authors.initials: H
authors.lastname: Kerl
mesh_terms: D000328:Adult; D002455:Cell Division; D003094:Collagen; D003593:Cytoplasm / Q000648:ultrastructure; D003594:Cytoplasmic Granules / Q000648:ultrastructure; D004817:Epidermis / Q000473:pathology / Q000648:ultrastructure; D005347:Fibroblasts / Q000473:pathology / Q000648:ultrastructure; D006644:Histiocytes / Q000473:pathology; D018219:Histiocytoma, Benign Fibrous / Q000473:pathology* / Q000648:ultrastructure; D006801:Humans; D007150:Immunohistochemistry; D015603:Keratinocytes / Q000473:pathology / Q000648:ultrastructure; D008247:Lysosomes / Q000648:ultrastructure; D008297:Male; D012867:Skin / Q000473:pathology / Q000648:ultrastructure; D012878:Skin Neoplasms / Q000473:pathology* / Q000648:ultrastructure; D014617:Vacuoles / Q000648:ultrastructure; D014746:Vimentin / Q000032:analysis
chemical_list: D014746:Vimentin; D003094:Collagen