Retinoic acid, neoplasia, differentiation and development.
Retinoic acid has pronounced effects on cultures of neoplastic cells. These have attracted the attention of pathologists, but it is important to note that much of the critical data about retinoic acid has been obtained from the current extension of our knowledge in the field of development. Some of these changes are reviewed here.
Berry
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Department of Morbid Anatomy and Histopathology, Royal London Hospital, Whitechapel, UK. C.L. Berry@mds.qmw.ac.uk
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000196:embryology; D002454:Cell Differentiation / Q000187:drug effects*; D002490:Central Nervous System / Q000187:drug effects / Q000196:embryology / Q000254:growth & development; D018878:Limb Buds / Q000187:drug effects / Q000196:embryology; D018168:Receptors, Retinoic Acid / Q000502:physiology; D014212:Tretinoin / Q000494:pharmacology*
D018168:Receptors, Retinoic Acid; D014212:Tretinoin