CML blast crisis resulting in biliary obstruction following BMT.
Allogeneic BMT is the treatment of choice for various hematologic malignancies. Despite careful patient scrutiny, a large number of patients experience significant morbidity and mortality due to procedure-related toxicity. Hepatobiliary toxicity presenting as biliary cholestasis, due to the preparative regimen (ie venoocclusive disease), supportive pharmaceuticals, and/or GVHD have been implicated. We report a unique cause of cholestasis in a patient undergoing BMT for CML. The cholestasis was found to be secondary to relapsed leukemia, which resulted in a granulocytic sarcoma obstructing the biliary ductal system.
Fleming
D R
DR
Division of Hematology/Oncology, University of Louisville, KY 40202, USA.
Slone
S P
SP
D001752:Blast Crisis / Q000150:complications*; D016026:Bone Marrow Transplantation / Q000009:adverse effects; D002779:Cholestasis / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology; D006504:Hepatic Veno-Occlusive Disease / Q000000981:diagnostic imaging / Q000209:etiology / Q000473:pathology; D006801:Humans; D015466:Leukemia, Myeloid, Chronic-Phase / Q000150:complications* / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D011859:Radiography; D012008:Recurrence; D014184:Transplantation, Homologous