Protection afforded by pyruvate during acute rejection of small-bowel allografts is mediated by inhibition of oxygen-free radicals and cytolytic activity (perforin and granzyme-B mRNA expression) in activated leukocytes.
Cicalese
L
L
Thomas E. Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pennsylvania 15213, USA.
Iyengar
A
A
Subbotin
V
V
Aitouche
A
A
Rastellini
C
C
Rao
A S
AS
Stanko
R T
RT
D000818:Animals; D005609:Free Radicals / Q000037:antagonists & inhibitors; D006084:Graft Rejection / Q000517:prevention & control*; D053804:Granzymes; D007421:Intestine, Small / Q000637:transplantation*; D007962:Leukocytes / Q000187:drug effects / Q000502:physiology*; D008562:Membrane Glycoproteins / Q000096:biosynthesis* / Q000097:blood; D054353:Perforin; D052899:Pore Forming Cytotoxic Proteins; D011773:Pyruvates / Q000494:pharmacology*; D012333:RNA, Messenger / Q000096:biosynthesis; D051381:Rats; D011912:Rats, Inbred ACI; D011917:Rats, Inbred Lew; D012697:Serine Endopeptidases / Q000096:biosynthesis* / Q000097:blood; D013602:T-Lymphocytes, Cytotoxic / Q000187:drug effects / Q000502:physiology; D014158:Transcription, Genetic / Q000187:drug effects*; D014184:Transplantation, Homologous / Q000276:immunology*
D005609:Free Radicals; D008562:Membrane Glycoproteins; D052899:Pore Forming Cytotoxic Proteins; D011773:Pyruvates; D012333:RNA, Messenger; D054353:Perforin; D053804:Granzymes; C509215:Gzmb protein, rat; D012697:Serine Endopeptidases