title: Auditory threshold sensitivity of the human neonate as measured by the auditory brainstem response.
abstract: The absolute auditory sensitivity of the human newborn infant was investigated using auditory brainstem response thresholds (ABR). ABRs were elicited with clicks and tone-bursts of 0.5, 1.5, 4.0 and 8.0 kHz, embedded in notched noise, in healthy, full-term human neonates and young adults with known, normal-hearing sensitivity. Stimuli were calibrated using a probe microphone positioned near the tympanic membrane in the ear canal of each subject to control for differences in resonance characteristics of infant and adult ear canals. ABR thresholds were also characterized relative to group psychophysical thresholds (nHL) and relative to individual psychophysical threshold or sensation level (SL) for the adult subjects. Infant ABR thresholds measured in p.e. SPL for all stimuli are elevated by to 3-25 dB relative to adult thresholds. Threshold elevation is greatest for the high-frequency stimuli. Result are consistent with neural immaturity for high-frequency stimuli in the auditory system of human neonates.
authors.affiliation: Children's Auditory Research and Evaluation Center, House Ear Institute, Los Angeles, CA 90057, USA. sininger@hei.org
authors.forename: Y S
authors.initials: YS
authors.lastname: Sininger
authors.forename: C
authors.initials: C
authors.lastname: Abdala
authors.forename: B
authors.initials: B
authors.lastname: Cone-Wesson
mesh_terms: D000161:Acoustic Stimulation; D000328:Adult; D001309:Auditory Threshold / Q000502:physiology*; D002138:Calibration; D016057:Evoked Potentials, Auditory, Brain Stem / Q000502:physiology*; D005260:Female; D006801:Humans; D007231:Infant, Newborn / Q000502:physiology*; D008297:Male; D014432:Tympanic Membrane / Q000502:physiology