title: Solitary fibrous tumor of the spinal cord.
abstract: We report a case of primary solitary fibrous tumor occurring in the intramedullary thoracic spinal cord in a 47-year-old man. The tumor predominately consisted of spindle cells separated by abundant collagen; a few areas of hemangiopericytomatous morphology were also present. The diagnosis was confirmed by immunohistochemistry and electron microscopy. The tumor was reactive to vimentin and CD34 but was negative for glial fibrillary acid protein (GFAP), S-100, smooth muscle actin, epithelial membrane antigen, HMB-45, myelin basic protein, and keratin; ultrastructural examination showed fairly undifferentiated cells within a collagenous matrix, few tight junctions, and sparse extravascular basement membrane. The occurrence of this tumor within the spinal cord parenchyma and in other extraserosal sites emphasizes the current belief that solitary fibrous tumors arise from mesenchymal tissues and are not restricted to the pleura and other serosal surfaces. Furthermore, solitary fibrous tumor is an entity that must be considered in the differential diagnosis of spindle cell central nervous system neoplasms.
authors.affiliation: Department of Pathology, University of Virginia School of Medicine, Charlottesville 22908, USA.
authors.forename: S R
authors.initials: SR
authors.lastname: Alston
authors.forename: P C
authors.initials: PC
authors.lastname: Francel
authors.forename: J A
authors.initials: JA
authors.lastname: Jane
mesh_terms: D003937:Diagnosis, Differential; D005350:Fibroma / Q000473:pathology / Q000648:ultrastructure; D006393:Hemangiopericytoma / Q000473:pathology / Q000648:ultrastructure; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008577:Meningeal Neoplasms / Q000473:pathology* / Q000648:ultrastructure; D008579:Meningioma / Q000473:pathology* / Q000648:ultrastructure; D008875:Middle Aged; D013120:Spinal Cord Neoplasms / Q000473:pathology* / Q000648:ultrastructure; D013899:Thoracic Neoplasms / Q000473:pathology* / Q000648:ultrastructure