Alcohol, GABAA-benzodiazepine receptor complex, and aggression.
Neurobiological investigations have become productive since experimental protocols were developed that engender large increases in aggressive behavior after acute alcohol challenges in individual experimental animals. Recent developments extended the heightened aggressive behavior to rats that self-administered alcohol shortly before the social confrontation. Quantitative ethological analysis revealed that alcohol prolongs "bursts" of aggressive acts and displays and disrupts communication between the aggressive animal and the opponent who defends, submits, or flees. Pharmacological modulation of the GABAA receptor with benzodiazepine agonists and neuroactive steroids results in dose-dependent biphasic changes in aggressive behavior that mimic the dose-effect function of alcohol; benzodiazepines potentiate the aggression-heightening effects of alcohol as well as the behaviorally suppressive effects; and antagonists at benzodiazepine receptors prevented the aggression-heightening effects of alcohol. The maturational and experiential origins for potentially distinctive GABAA receptor characteristics in individuals who exhibit heightened aggressive behavior await identification.
Miczek
K A
KA
Department of Psychology, Tufts University, Medford, Massachusetts 02155, USA.
DeBold
J F
JF
van Erp
A M
AM
Tornatzky
W
W
D000374:Aggression / Q000187:drug effects* / Q000502:physiology; D000428:Alcohol Drinking / Q000009:adverse effects / Q000503:physiopathology; D000435:Alcoholic Intoxication / Q000503:physiopathology; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000503:physiopathology; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000494:pharmacology*; D006801:Humans; D051381:Rats; D011963:Receptors, GABA-A / Q000187:drug effects* / Q000502:physiology
D011963:Receptors, GABA-A; D000431:Ethanol