Reduction of oxazepam to desmethyldiazepam by human intestinal bacteria.
The biotransformation of oxazepam by Bifidobacterium bifidum was studied. The major metabolite was purified by chromatographic methods and found to be desmethyldiazepam using NMR, IR and other physicochemical data.
Okamura
T
T
Osaka Perfectural Institute of Public Health, Japan.
Sugiura
W
W
Miyazawa
M
M
D001644:Bifidobacterium / Q000502:physiology; D001711:Biotransformation; D006801:Humans; D007422:Intestines / Q000382:microbiology*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D015394:Molecular Structure; D003708:Nordazepam / Q000378:metabolism*; D010076:Oxazepam / Q000378:metabolism*; D010084:Oxidation-Reduction; D013053:Spectrophotometry
D003708:Nordazepam; D010076:Oxazepam