Life and death in the cytoplasm: messages from the 3' end.
The cytoplasmic life of an mRNA revolves around the regulation of its localization, translation and stability. Interactions between the two ends of the mRNA may integrate translation and mRNA turnover. Regulatory elements in the region between the termination codon and poly(A) tail - the 3' untranslated region - have been identified in a wide variety of systems, as have been some of the key players with which these elements interact.
Wickens
M
M
Department of Biochemistry, University of Wisconsin, Madison, Wisconsin, 53706, USA. wickens@biochem.wisc.edu
Anderson
P
P
Jackson
R J
RJ
D000818:Animals; D003593:Cytoplasm; D006801:Humans; D009154:Mutation; D011061:Poly A; D014176:Protein Biosynthesis; D012333:RNA, Messenger; D012045:Regulatory Sequences, Nucleic Acid; D014157:Transcription Factors; D015003:Yeasts
D012333:RNA, Messenger; D014157:Transcription Factors; D011061:Poly A