title: Comparative three-year caries protection from an aluminum-containing and a fluoride-containing toothpaste.
abstract: In the present study, 2,087 fifth-graders (mean age: 12 years) from two cohorts entered a 3-year clinical toothpaste trial. The study subjects were randomly allocated to two groups: one group was a positive control using a 0.83% NaFPO3 toothpaste, while the other group brushed with a test toothpaste containing 1.77% KAl(SO4). Both toothpastes were used unsupervised at home. One set of bite-wing radiographs was obtained at the beginning of the trial and another at the 3-year follow-up. Clinical registrations of caries were performed by the municipal dentists responsible for the child's dental care. After 3 years, the mean caries increment was significantly higher in the group using the aluminum-containing toothpaste measured both clinically and radiographically.
authors.affiliation: Computer Science Section, Royal Dental College, Faculty of Health Sciences, University of Aarhus, Denmark.
authors.forename: J
authors.initials: J
authors.lastname: Heidmann
authors.forename: S
authors.initials: S
authors.lastname: Poulsen
mesh_terms: D000534:Alum Compounds / Q000627:therapeutic use*; D002327:Cariostatic Agents / Q000627:therapeutic use*; D002648:Child; D004245:DMF Index; D003731:Dental Caries / Q000517:prevention & control*; D004311:Double-Blind Method; D005260:Female; D005459:Fluorides / Q000627:therapeutic use; D006801:Humans; D015994:Incidence; D008137:Longitudinal Studies; D008297:Male; D010710:Phosphates / Q000627:therapeutic use; D012969:Sodium Fluoride / Q000627:therapeutic use*; D014100:Toothpastes / Q000627:therapeutic use*
chemical_list: D000534:Alum Compounds; D002327:Cariostatic Agents; D010710:Phosphates; D014100:Toothpastes; C012980:fluorophosphate; C041524:aluminum sulfate; D012969:Sodium Fluoride; D005459:Fluorides