Relevance of the application of pharmacokinetic-pharmacodynamic modelling concepts in drug development. The "wooden shoe' paradigm.
Breimer
D D
DD
Leiden/Amsterdam Center for Drug Research, Division of Pharmacology, Leiden University, The Netherlands.
Danhof
M
M
D000818:Animals; D002986:Clinical Trials as Topic; D004305:Dose-Response Relationship, Drug; D016503:Drug Delivery Systems / Q000592:standards; D015195:Drug Design; D006801:Humans; D008956:Models, Chemical; D010599:Pharmacokinetics; D010600:Pharmacology / Q000379:methods*