title: Cyclophosphamide in severe steroid-resistant bronchiolitis obliterans organizing pneumonia.
abstract: A patient receiving carbamazepine and imipramine presented with severe bronchiolitis obliterans organizing pneumonia (BOOP). He developed progressive respiratory failure in spite of high-dose steroid treatment. Cyclophosphamide was given as adjunctive therapy, and a rapid improvement was seen. The authors suggest that an early therapeutic trial of cyclophosphamide should be considered in patients with BOOP who fail to respond to steroids.
authors.affiliation: Newcastle General Hospital, Newcastle upon Tyne, U.K.
authors.forename: I F
authors.initials: IF
authors.lastname: Purcell
authors.forename: S J
authors.initials: SJ
authors.lastname: Bourke
authors.forename: S M
authors.initials: SM
authors.lastname: Marshall
mesh_terms: D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D018549:Cryptogenic Organizing Pneumonia / Q000188:drug therapy*; D003520:Cyclophosphamide / Q000627:therapeutic use*; D004351:Drug Resistance; D004359:Drug Therapy, Combination; D006801:Humans; D008297:Male; D008875:Middle Aged; D011239:Prednisolone / Q000627:therapeutic use*
chemical_list: D000893:Anti-Inflammatory Agents; D003520:Cyclophosphamide; D011239:Prednisolone