title: A mouse model of Borrelia meningitis after intradermal injection.
abstract: Both young and adult C3H/HeN mice developed meningitis within 3 weeks of intradermal inoculation with a newly identified uncultivable Borrelia species, an agent of human relapsing fever. Meningoencephalitis with perivascular infiltrates and plexitis developed at approximately 25 days after inoculation. Infiltrates were composed of B and plasma cells and monocytes. This model recreated the meningitis associated with spirochetal infections through an intradermal route of infection.
authors.affiliation: Seccion de Neurologia, Hospital de Galdacano, Vizcaya, Spain.
authors.forename: J C
authors.initials: JC
authors.lastname: Garcia-Monco
authors.forename: N S
authors.initials: NS
authors.lastname: Miller
authors.forename: P B
authors.initials: PB
authors.lastname: Backenson
authors.forename: P
authors.initials: P
authors.lastname: Anda
authors.forename: J L
authors.initials: JL
authors.lastname: Benach
mesh_terms: D000375:Aging; D000818:Animals; D001402:B-Lymphocytes / Q000473:pathology; D001898:Borrelia / Q000145:classification* / Q000302:isolation & purification; D001899:Borrelia Infections / Q000473:pathology / Q000503:physiopathology*; D001921:Brain / Q000473:pathology*; D006801:Humans; D016920:Meningitis, Bacterial / Q000473:pathology / Q000503:physiopathology*; D008590:Meningoencephalitis / Q000473:pathology / Q000503:physiopathology*; D051379:Mice; D008809:Mice, Inbred C3H; D009000:Monocytes / Q000473:pathology; D010950:Plasma Cells / Q000473:pathology; D012061:Relapsing Fever / Q000382:microbiology; D013997:Time Factors