Stimulatory effect of (R) alpha-methylhistamine on duodenal HCO3- secretion in anaesthetized rats.
The effect of the histamine H3 receptor agonist (R) alpha-methylhistamine on duodenal bicarbonate secretion was investigated in the anaesthetized rat. (R) alpha-methylhistamine (3-30 mumol/kg i.v.) caused a dose-dependent increase in alkaline secretion which was completely blocked by the H3 receptor antagonist clobenpropit (3 mumol/kg i.v.). This antagonist caused a slight reduction (19%) of the secretory response to PGE2 50 micrograms/kg i.v. These data indicate that the alkaline response to (R) alpha-methylhistamine is related to the activation of histamine H3 receptors and suggest that this could be an additional mechanism involved in the previously observed gastroprotective effect of this compound.
Coruzzi
G
G
Istituto di Farmacologia, Università di Parma, Italy.
Gambarelli
E
E
Bertaccini
G
G
D000758:Anesthesia; D000818:Animals; D001639:Bicarbonates / Q000378:metabolism*; D015232:Dinoprostone / Q000008:administration & dosage / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004386:Duodenum / Q000187:drug effects / Q000378:metabolism* / Q000601:surgery; D017442:Histamine Agonists / Q000008:administration & dosage / Q000494:pharmacology*; D006633:Histamine Antagonists / Q000008:administration & dosage / Q000494:pharmacology; D007093:Imidazoles / Q000494:pharmacology; D007262:Infusions, Intravenous; D008297:Male; D008761:Methylhistamines / Q000008:administration & dosage / Q000494:pharmacology*; D010120:Oxytocics / Q000008:administration & dosage / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013268:Stimulation, Chemical; D013890:Thiourea / Q000031:analogs & derivatives / Q000494:pharmacology
D001639:Bicarbonates; D017442:Histamine Agonists; D006633:Histamine Antagonists; D007093:Imidazoles; D008761:Methylhistamines; D010120:Oxytocics; C069357:alpha-methylhistamine; D013890:Thiourea; D015232:Dinoprostone; C086108:clobenpropit