Antiallergic activity of alkyl substituted pyrazolo[3, 4-d]pyrimidine (compound 88-765).
Compound 88-765 (4-amino-6-methylthio-1-(2', 2'-diethoxyethyl)-1 H-pyrazolo[3, 4-d]pyrimidine) has shown potent antiallergic activity in experimental models. The compound inhibited the passive cutaneous anaphylaxis (PCA) reaction in rats in dose-dependent manner (5-100 mg/kg, po) by 47 to 87%. In mice it inhibited PCA by 78% at 50 mg/kg, po. It also inhibited mast cell degranulation of normal and passively sensitised rats induced by compound 48/80 and egg albumin, respectively. These effects of Compound 88-765 were comparable with that of disodium cromoglycate (DSCG). The results suggest that compound 88-765 possesses potent antiallergic activity.
Gupta
P P
PP
Division of Pharmacology, Central Drug Research Institute, Lucknow, India.
Srimal
R C
RC
Avasthi
K
K
Garg
N
N
Chandra
T
T
Bhakuni
D S
DS
D000818:Animals; D018926:Anti-Allergic Agents / Q000494:pharmacology*; D004205:Cromolyn Sodium / Q000494:pharmacology; D008297:Male; D008407:Mast Cells / Q000187:drug effects; D051379:Mice; D010323:Passive Cutaneous Anaphylaxis / Q000187:drug effects; D011720:Pyrazoles / Q000494:pharmacology*; D011743:Pyrimidines / Q000494:pharmacology*; D051381:Rats
D018926:Anti-Allergic Agents; D011720:Pyrazoles; D011743:Pyrimidines; C105901:4-amino-6-methylthio-1-(2',2'-diethoxyethyl)-1H-pyrazolo(3,4-d)pyrimidine; D004205:Cromolyn Sodium