title: Redistribution of synaptic efficacy: a mechanism to generate infinite synaptic input diversity from a homogeneous population of neurons without changing absolute synaptic efficacies.
abstract: Changing the reliability of neurotransmitter release results in a change in the efficacy of low frequency synaptic transmission and in the rate of high frequency synaptic depression thus it can not cause an uniform change in strength of synapses and instead results in a change in the dynamics of synaptic transmission referred to as 'redistribution of synaptic efficacy' (RSE). Since the change in synaptic transmission associated with RSE depends on the history of action potential activity it is concluded that RSE serves as a mechanism to generate a potentially infinite diversity of synaptic input.
authors.affiliation: Department of Neurobiology, Weizmann Institute for Science, Rehovot, Israel.
authors.forename: H
authors.initials: H
authors.lastname: Markram
authors.forename: M
authors.initials: M
authors.lastname: Tsodyks
mesh_terms: D000200:Action Potentials / Q000502:physiology; D000818:Animals; D005071:Evoked Potentials / Q000502:physiology; D009412:Nerve Fibers / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D018377:Neurotransmitter Agents / Q000378:metabolism*; D016012:Poisson Distribution; D011336:Probability; D009435:Synaptic Transmission / Q000502:physiology*
chemical_list: D018377:Neurotransmitter Agents