title: mu-Opioid receptor binding in chicken brain in relation to degree of food restriction: a quantitative autoradiographic study.
abstract: Quantitative receptor autoradiography was used to measure differences in [3H]DAGO binding to mu-opioid receptors in selected fore- and midbrain regions of chickens subject to varying degrees of chronic food restriction: either R (a recommended restricted ration), 2R (twice recommended restricted ration) or AL (ad libitum). A significant increase in binding of 75% was observed in the paleostriatum primitivum (a homologue of the mammalian globus pallidus) with the R treatment compared to the 2R and AL treatments. This finding concurs with results of earlier pharmacological manipulations with opioid antagonists, which indicated that activation of mu-opioid receptors plays a contributory role in reinforcement of post-feeding oral stereotypies in chickens subject to the same R treatment.
authors.affiliation: Brain and Behaviour Research Group, Department of Biology, The Open University, Milton Keynes, UK.
authors.forename: M G
authors.initials: MG
authors.lastname: Stewart
authors.forename: C J
authors.initials: CJ
authors.lastname: Savory
authors.forename: E
authors.initials: E
authors.lastname: Harrison
mesh_terms: D000818:Animals; D001345:Autoradiography; D001665:Binding Sites / Q000187:drug effects*; D001921:Brain / Q000187:drug effects*; D002645:Chickens; D005260:Female; D005508:Food Deprivation / Q000502:physiology*; D017450:Receptors, Opioid, mu / Q000187:drug effects*
chemical_list: D017450:Receptors, Opioid, mu