Enantiomeric resolution by HPLC of axial chiral amides using amylose tris[(S)-1-phenylethylcarbamate].
The enantiomeric resolution of a series of N-arylamides was examined on amylose tris[(S)-1-phenylethylcarbamate] coated onto aminopropylated 7 microns silica with 500 A diameter pores and on naked silica 5 microns particle size with 500 A diameter pores. The enantiomeric resolution obtained for this series was excellent on both columns. The enantioselectivity of cellulose and amylose tris(3,5-dimethylphenylcarbamate) coated onto APS-Hypersil (120 A pore size, 5 microns particle size) was also investigated for this series of compounds.
Cass
Q B
QB
Departamento de Química, Universidade Federal de São Carlos, Brazil.
Degani
A L
AL
Tiritan
M E
ME
Matlin
S A
SA
Curran
D P
DP
Balog
A
A
D000577:Amides / Q000737:chemistry / Q000302:isolation & purification*; D000688:Amylose / Q000031:analogs & derivatives* / Q000737:chemistry; D002482:Cellulose; D002851:Chromatography, High Pressure Liquid; D007475:Ion Exchange Resins; D010316:Particle Size; D013056:Spectrophotometry, Ultraviolet; D013237:Stereoisomerism
D000577:Amides; D007475:Ion Exchange Resins; C106151:amylose tris(1-phenylethylcarbamate); D002482:Cellulose; D000688:Amylose