title: Bilateral reduction mammoplasty in a patient treated with calcium channel blocker and cyclosporine after renal transplant: a case report.
abstract: A 28-year-old woman with end-stage renal disease secondary to diabetes mellitus and hypertension underwent cadaver renal transplant in April 1992. After surgery, she developed bilateral breast enlargement while she was taking cyclosporine for immunosuppression therapy and felodipine, a calcium channel blocker, for blood pressure control. She underwent bilateral reduction mammoplasty in June 1995 to treat progressive breast enlargement which interfered with her normal life activities. Through mechanisms only partially understood, calcium channel blockers and cyclosporine are reported to increase the serum prolactin level, producing gynecomastia in men. There is no report in current literature to support a similar phenomenon in women.
authors.affiliation: Department of Surgery, The University of Tennessee Medical Center at Knoxville 37920, USA.
authors.forename: Y
authors.initials: Y
authors.lastname: Pan
authors.forename: A
authors.initials: A
authors.lastname: Grindstaff
authors.forename: D
authors.initials: D
authors.lastname: Cassada
authors.forename: M
authors.initials: M
authors.lastname: Goldman
authors.forename: J
authors.initials: J
authors.lastname: Taylor
mesh_terms: D000328:Adult; D001941:Breast Diseases / Q000097:blood / Q000139:chemically induced* / Q000601:surgery*; D002102:Cadaver; D002121:Calcium Channel Blockers / Q000009:adverse effects*; D016572:Cyclosporine / Q000009:adverse effects*; D015736:Felodipine / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D007676:Kidney Failure, Chronic / Q000601:surgery*; D016030:Kidney Transplantation; D008297:Male; D016462:Mammaplasty; D011388:Prolactin / Q000097:blood
chemical_list: D002121:Calcium Channel Blockers; D007166:Immunosuppressive Agents; D016572:Cyclosporine; D011388:Prolactin; D015736:Felodipine