Chronic electroconvulsive shock but not lithium reduces density of (+)[3H]pentazocine binding sites in rat hippocampus.
The aim of the present study was to investigate the effect of chronic treatment with electroconvulsive shock (ECS) or lithium on (+)[3H]pentazocine binding to sigma-1 receptors in the rat hippocampus. Chronic ECS resulted in a reduction in the density with no change in affinity of (+)[3H]pentazocine binding to sigma-1 receptors in the rat hippocampus. Chronic lithium administration, however, failed to affect this binding. These data suggest that sigma-1 receptors may be involved in the mechanism of antidepressive but not antimanic therapy.
Nowak
G
G
Institute of Pharmacology, Polish Academy of Sciences, Kraków, Poland.
D000818:Animals; D001665:Binding Sites / Q000187:drug effects; D004597:Electroshock; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism*; D008094:Lithium / Q000494:pharmacology*; D008297:Male; D010423:Pentazocine / Q000378:metabolism*; D011485:Protein Binding / Q000187:drug effects; D011849:Radioactive Tracers; D051381:Rats; D017208:Rats, Wistar; D017480:Receptors, sigma / Q000187:drug effects / Q000378:metabolism; D014316:Tritium
D011849:Radioactive Tracers; D017480:Receptors, sigma; D014316:Tritium; D008094:Lithium; D010423:Pentazocine