title: Insulin-like growth factors and their binding proteins in the venous effluents of ovary and adrenal gland in severely hyperandrogenic women.
abstract: Insulin and insulin-like growth factors (IGF) are thought to play an important role in the pathogenesis of excessive androgen production. To explore this question further we measured the concentrations of IGF-I and -II and their binding proteins (IGFBP-1 and-3) in adrenal and ovarian vein samples of severely hyperandrogenic women (serum testosterone > 5 nmol/l) collected as part of their diagnostic work-up. The concentration of IGF-II was slightly but not significantly higher in the ovarian vein than in the adrenal and peripheral veins. The concentrations of IGF-I and IGFBP were identical in both the adrenal and ovarian veins and did not differ from those in the peripheral circulation. The concentration of IGFBP-1 was negatively correlated (r = -0.60, P > 0.05) with insulin and IGFBP-3 showed a strong positive correlation with IGF-1 (r = 0.90, P > 0.01). These results indicate that neither the ovary nor the adrenal gland contributes significantly to the circulating pool of IGF or their binding proteins in severely hyperandrogenic subjects. Hyperinsulinaemia is associated with low circulating IGFBP-1 concentrations and IGFBP-3 seems to be an excellent indicator of the peripheral IGF-I concentration. The concentrations of IGF-I suggested decreased somatotrophic activity in these obese, hyperinsulinaemic subjects.
authors.affiliation: Department of Obstetrics and Gynecology, University Central Hospital of Oulu, Kajaanintie, Finland.
authors.forename: H
authors.initials: H
authors.lastname: Martikainen
authors.forename: P
authors.initials: P
authors.lastname: Salmela
authors.forename: S
authors.initials: S
authors.lastname: Nuojua-Huttunen
authors.forename: J
authors.initials: J
authors.lastname: Perälä
authors.forename: S
authors.initials: S
authors.lastname: Leinonen
authors.forename: M
authors.initials: M
authors.lastname: Knip
authors.forename: A
authors.initials: A
authors.lastname: Ruokonen
mesh_terms: D000311:Adrenal Glands / Q000098:blood supply / Q000378:metabolism; D000328:Adult; D005260:Female; D006801:Humans; D017588:Hyperandrogenism / Q000503:physiopathology*; D018970:Insulin-Like Growth Factor Binding Protein 1 / Q000097:blood / Q000378:metabolism*; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000097:blood / Q000378:metabolism*; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D007335:Insulin-Like Growth Factor II / Q000378:metabolism*; D010053:Ovary / Q000098:blood supply / Q000378:metabolism; D014680:Veins
chemical_list: D018970:Insulin-Like Growth Factor Binding Protein 1; D018972:Insulin-Like Growth Factor Binding Protein 3; D007334:Insulin-Like Growth Factor I; D007335:Insulin-Like Growth Factor II