title: Further clinical delineation and increased morbidity in males with osteopathia striata with cranial sclerosis: an X-linked disorder?
abstract: Osteopathia striata with cranial sclerosis (OS-CS) is a bone dysplasia characterized by hypertelorism, macrocephaly, frontal bossing, broad nasal bridge, palate anomalies, hearing deficits, and mental retardation. The radiographic findings include cranial sclerosis, linear striations in the long bones and iliac wings, small poorly aerated sinuses, scoliosis, and increased bone density. The sensory deficits are disabling, but the condition generally is not life threatening. We describe 4 brothers with the characteristics of OS-CS, 3 of whom have died from more serious complications of the disorder. The mother of these children, and her only daughter, have the mildest phenotype with the typical linear striations in the long bones and macrocephaly. OS-CS is thought to be autosomal dominant with complete penetrance and variable expressivity. Our observations could be consistent with X-linkage, since there is milder expression in the female relatives. In addition, we recognize absent fibulae, malrotation, and omphalocele as new manifestations as well as congenital heart disease.
authors.affiliation: Division of Human Genetics and Molecular Biology, The Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, 19104, USA.
authors.forename: J E
authors.initials: JE
authors.lastname: Pellegrino
authors.forename: D M
authors.initials: DM
authors.lastname: McDonald-McGinn
authors.forename: A
authors.initials: A
authors.lastname: Schneider
authors.forename: R I
authors.initials: RI
authors.lastname: Markowitz
authors.forename: E H
authors.initials: EH
authors.lastname: Zackai
mesh_terms: D001848:Bone Diseases, Developmental / Q000151:congenital* / Q000000981:diagnostic imaging; D001842:Bone and Bones / Q000002:abnormalities* / Q000000981:diagnostic imaging; D005190:Family; D005260:Female; D008040:Genetic Linkage; D006554:Hernia, Umbilical; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D011859:Radiography; D012598:Sclerosis / Q000151:congenital*; D012886:Skull / Q000000981:diagnostic imaging / Q000473:pathology*; D014960:X Chromosome / Q000235:genetics