title: Comparison of ossification of demineralized bone, hydroxyapatite, Gelfoam, and bone wax in cranial defect repair.
abstract: Demineralized bone allografts in the repair of calvarial defects are compared with other common bone fillers. This study uses a video-digitizing radiographic analysis of calvarial defect ossification to determine calcification of bone defects and its relation to postoperative clinical examination and regional controls. The postoperative clinical results at 3 months demonstrated that bony healing was greatest in bur holes filled with demineralized bone and hydroxyapatite. Radiographic analysis demonstrated calcification of demineralized bone-filled defects compared to bone wax- and Gelfoam-filled regions. Hydroxyapatite granules are radiographically dense, thus not allowing accurate measurement of true bone healing. The results suggest that demineralized bone and hydroxyapatite provide better structural support via bone healing to defined calvarial defects than do Gelfoam and bone wax.
authors.affiliation: Department of Plastic and Reconstructive Surgery, Cleveland Clinic Foundation, OH 44195, USA.
authors.forename: F A
authors.initials: FA
authors.lastname: Papay
authors.forename: L
authors.initials: L
authors.lastname: Morales
authors.forename: O F
authors.initials: OF
authors.lastname: Ahmed
authors.forename: D
authors.initials: D
authors.lastname: Neth
authors.forename: S
authors.initials: S
authors.lastname: Reger
authors.forename: J
authors.initials: J
authors.lastname: Zins
mesh_terms: D001861:Bone Regeneration; D018786:Bone Substitutes; D016025:Bone Transplantation / Q000379:methods; D002648:Child; D003399:Craniotomy / Q000379:methods; D017886:Durapatite; D005260:Female; D005781:Gelatin Sponge, Absorbable; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D016348:Osseointegration; D010012:Osteogenesis; D010168:Palmitates; D012886:Skull / Q000601:surgery*; D014885:Waxes; D014945:Wound Healing
chemical_list: D018786:Bone Substitutes; D010168:Palmitates; D014885:Waxes; D017886:Durapatite