Induction of anticardiolipin antibody and/or lupus anticoagulant in rabbits by immunization with lipoteichoic acid, lipopolysaccharide and lipid A.
It still remains unclear how anti-phospholipid antibody develops in a specific patient group, however, it is possible that certain microorganism(s) may cause anti-cardiolipin antibody (aCL) development since aCL is frequently detected in patients with Treponema pallidum (TP) and/or other infectious diseases. Accordingly, we conducted an investigation to clarify whether or not anticardiolipin antibody (aCL) and/or lupus anticoagulant (LA) can be induced in rabbits by immunization with Gram-positive or -negative microorganism derivatives, such as lipoteichoic acid, lipopolysaccharide and lipid A. We detected the induction of SLE type-aCL (beta 2GPI-dependent) and LA in some rabbits immunized with lipid A and lipoteichoic acid, thereby suggesting that some microorganisms may contribute to even the production of pathogenic (SLE-type) antiphospholipid antibody.
Gotoh
M
M
Department of Medicine, Teikyo University School of Medicine, Tokyo, Japan.
Matsuda
J
J
D000818:Animals; D017153:Antibodies, Anticardiolipin / Q000276:immunology*; D000917:Antibody Formation; D007114:Immunization; D008050:Lipid A / Q000276:immunology*; D008070:Lipopolysaccharides / Q000276:immunology*; D016682:Lupus Coagulation Inhibitor / Q000276:immunology*; D011817:Rabbits; D013682:Teichoic Acids / Q000276:immunology*
D017153:Antibodies, Anticardiolipin; D008050:Lipid A; D008070:Lipopolysaccharides; D016682:Lupus Coagulation Inhibitor; D013682:Teichoic Acids; C009900:lipoteichoic acid