title: Indobufen induced modification of phospholipid composition in diabetic platelets.
abstract: The influence of indobufen (200 mg twice daily for 10 days) on platelet lipid peroxidation and phospholipid metabolism in diabetic patients was investigated. We have studied 18 patients with type I of diabetes mellitus. The duration of disease varied between 3 and 25 years (average 11 years). All patients showed symptoms of diabetic angiopathy. Investigations were carried out after restoring the carbohydrate balance. The following tests were performed before and after a 10 day treatment with indobufen: malondialdehyde, conjugated dienes and lipid hydroperoxides, phospholipids, fatty acids. We observed a significantly higher production of lipid peroxidation products in diabetic platelets compared to control platelets. After a 10 day treatment with indobufen the intensity of peroxidation lowered significantly. The phospholipid composition of diabetic platelets showed a significant increase in lysophosphoglycerides fraction compared to the control platelets. After the indobufen treatment a significant decrease in sphingomyelin content was observed. In other phospholipid fractions no significant differences were observed.
authors.affiliation: Department of Haematology, Medical Academy, Lublin, Poland.
authors.forename: A
authors.initials: A
authors.lastname: Dmoszyńska
authors.forename: B
authors.initials: B
authors.lastname: Sokołowska
authors.forename: A
authors.initials: A
authors.lastname: Walter-Croneck
authors.forename: K
authors.initials: K
authors.lastname: Przesmycki
authors.forename: A
authors.initials: A
authors.lastname: Ledwozyw
mesh_terms: D000328:Adult; D000368:Aged; D001792:Blood Platelets / Q000378:metabolism*; D003922:Diabetes Mellitus, Type 1 / Q000097:blood*; D003925:Diabetic Angiopathies / Q000097:blood; D005260:Female; D006801:Humans; D054833:Isoindoles; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D010654:Phenylbutyrates / Q000494:pharmacology*; D010712:Phosphatidic Acids / Q000097:blood; D010743:Phospholipids / Q000097:blood*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D013109:Sphingomyelins / Q000097:blood
chemical_list: D054833:Isoindoles; D010654:Phenylbutyrates; D010712:Phosphatidic Acids; D010743:Phospholipids; D010975:Platelet Aggregation Inhibitors; D013109:Sphingomyelins; C020371:indobufen