Extracorporeal membrane oxygenation for transport of hypoxaemic patients with severe ARDS.
Conventional inter-hospital transfer of patients with severe acute respiratory distress syndrome (ARDS) in need of extracorporeal membrane oxygenation (ECMO) may be risky and in severe hypoxaemic patients may be associated with cerebral hypoxia and death. Therefore, we began a phase 1 study to evaluate the feasibility, complications and outcome of inter-hospital transport of these patients using veno-venous ECMO. Eight patients with severe ARDS and a PaO2/FIO2 < 6.7 kPa at a PEEP > or = 10 cm H2O were placed on a mobile ECMO at the referring hospital. The 495 (SD 123) km inter-hospital transport via a special ground ambulance took 341 (151) min. After transfer, blood-gas tensions were improved in spite of less optimal ventilator settings, compared with data before the start of ECMO. No significant complications occurred. Six patients survived and were discharged from hospital; two patients died because of multiple organ failure. We conclude that initiation of ECMO in hypoxaemic patients before inter-hospital transfer is feasible and enables safe transport to an ECMO centre.
Rossaint
R
R
Klinik für Anaesthesiologie und operative Intensivmedizin, Virchow-Klinikum der Medizinischen Fakultät der Humboldt-Universität zu Berlin, Germany.
Pappert
D
D
Gerlach
H
H
Lewandowski
K
K
Keh
D
D
Falke
K
K
D000328:Adult; D000553:Ambulatory Care / Q000379:methods; D002648:Child; D015199:Extracorporeal Membrane Oxygenation; D005240:Feasibility Studies; D005260:Female; D006439:Hemodynamics; D006801:Humans; D000860:Hypoxia / Q000503:physiopathology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D010360:Patient Transfer / Q000379:methods*; D011659:Pulmonary Gas Exchange; D012128:Respiratory Distress Syndrome / Q000503:physiopathology / Q000628:therapy*; D016896:Treatment Outcome