title: Expression of Radical fringe in limb-bud ectoderm regulates apical ectodermal ridge formation.
abstract: The apical ectodermal ridge of the vertebrate limb bud lies at the junction of the dorsal and ventral ectoderm and directs patterning of the growing limb. Its formation is directed by the boundary between cells that do and cells that do not express the gene Radical fringe. This is similar to the establishment of the margin cells at the Drosophila wing dorsoventral border by fringe. Radical fringe expression in chick-limb dorsal ectoderm is established in part through repression by Engrailed-1 in the ventral ectoderm.
authors.affiliation: Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.
authors.forename: E
authors.initials: E
authors.lastname: Laufer
authors.forename: R
authors.initials: R
authors.lastname: Dahn
authors.forename: O E
authors.initials: OE
authors.lastname: Orozco
authors.forename: C Y
authors.initials: CY
authors.lastname: Yeo
authors.forename: J
authors.initials: J
authors.lastname: Pisenti
authors.forename: D
authors.initials: D
authors.lastname: Henrique
authors.forename: U K
authors.initials: UK
authors.lastname: Abbott
authors.forename: J F
authors.initials: JF
authors.lastname: Fallon
authors.forename: C
authors.initials: C
authors.lastname: Tabin
mesh_terms: D000818:Animals; D030161:Avian Proteins; D005075:Biological Evolution; D019521:Body Patterning / Q000235:genetics / Q000502:physiology; D002642:Chick Embryo; D003001:Cloning, Molecular; D004330:Drosophila / Q000196:embryology; D029721:Drosophila Proteins; D004475:Ectoderm / Q000502:physiology; D004627:Embryonic Induction / Q000502:physiology; D015870:Gene Expression; D005822:Genetic Vectors; D016695:Glycosyltransferases; D018398:Homeodomain Proteins / Q000502:physiology; D017403:In Situ Hybridization; D018878:Limb Buds / Q000196:embryology* / Q000502:physiology; D008565:Membrane Proteins / Q000378:metabolism; D009154:Mutation; D014176:Protein Biosynthesis; D011506:Proteins / Q000235:genetics / Q000502:physiology*; D051880:Receptors, Notch; D012190:Retroviridae / Q000235:genetics; D015398:Signal Transduction; D014921:Wings, Animal / Q000196:embryology
chemical_list: D030161:Avian Proteins; D029721:Drosophila Proteins; D018398:Homeodomain Proteins; D008565:Membrane Proteins; C497759:N protein, Drosophila; D011506:Proteins; D051880:Receptors, Notch; D016695:Glycosyltransferases; C498394:LFNG protein, Gallus gallus