title: Toxicities of O-alkyl S-(2-dialkylaminoethyl) methyl phosphonothiolates (V-compounds).
abstract: Toxicities expressed as LD50 values of O-alkyl S-(2-dialkylaminoethyl) methyl phosphonothiolates in different species and different routes of administration were determined. Rats were more sensitive to these compounds than mice, rabbits and guinea-pigs were more sensitive than mice and rats. The most sensitive to these compounds were dogs. LD50 values varied in a wide range, however, a decrease of toxicity was observed in the following rank: i.v., i.m., s.c., i.p., p.o. and p.c., respectively. Depending on the route of administration, LD50 values varied from 5 g/kg (i.m., dogs) through tens of microgram/kg for the most part of compounds and routes of administration to hundreds, rarely thousands of g/kg (some chemicals, p.c. administration).
authors.affiliation: Purkynĕ Military Medical Academy, Hradec Králové.
authors.forename: J
authors.initials: J
authors.lastname: Vachek
authors.forename: V
authors.initials: V
authors.lastname: Gersl
authors.forename: J
authors.initials: J
authors.lastname: Fusek
authors.forename: O
authors.initials: O
authors.lastname: Krs
authors.forename: F
authors.initials: F
authors.lastname: Skopec
authors.forename: J
authors.initials: J
authors.lastname: Bajgar
mesh_terms: D000818:Animals; D002619:Chemical Warfare Agents / Q000633:toxicity*; D004285:Dogs; D006168:Guinea Pigs; D051379:Mice; D009946:Organothiophosphorus Compounds / Q000008:administration & dosage / Q000633:toxicity*; D011817:Rabbits; D051381:Rats
chemical_list: D002619:Chemical Warfare Agents; D009946:Organothiophosphorus Compounds