Antimalarial activity of 1,4-epidioxy-bisabola-2,12-diene derivatives.
1,4-Epidioxy-bisabola-2,12-diene (3) and aromatic hydroperoxides (4, 5) were prepared by photoxidation of gamma-curcumene (1). Reduction and esterification of 6 and 7 afforded compounds 9 to 10. All compounds were tested in vitro for antimalarial activity. The activity could not be increased significantly, compared with 3. The most active compounds, 3 and 9, did not show in vivo antimalarial activity in mice.
Rücker
G
G
Institut für Pharmazeutische Chemie, Universität Bonn.
Breitmaier
E
E
Manns
D
D
Maier
W
W
Marek
A
A
Heinzmann
B
B
Heiden
K
K
Seggewies
S
S
D000818:Animals; D000962:Antimalarials / Q000138:chemical synthesis* / Q000494:pharmacology*; D003474:Curcumin / Q000031:analogs & derivatives / Q000737:chemistry; D005260:Female; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008815:Mice, Inbred Strains; D010777:Photochemistry; D012717:Sesquiterpenes / Q000138:chemical synthesis* / Q000494:pharmacology*
C106120:1,4-epidioxybisabola-2,12-diene; D000962:Antimalarials; D012717:Sesquiterpenes; D003474:Curcumin