Low levels of human decidua-associated protein 200 in uterine fluid reflect pathological conditions of the endometrium.
Uterine fluid levels of human decidua-associated protein (hDP) 200 were measured in regularly cycling fertile women, postmenopausal women with normal endometrium and in women with endometrial hyperplasia or endometrial carcinoma. A statistically significant decrease in hDP 200 levels (p < 0.0001) was observed in postmenopausal women and in women with endometrial hyperplasia or carcinoma as compared with regularly cycling women possessing a normal endometrium. Furthermore, a significant increase in the uterine fluid hDP 200 level (p < 0.0008) was observed in women with endometrial hyperplasia following treatment with medroxyprogesterone acetate. These findings suggest that uterine fluid hDP 200 may be a useful marker for screening endometrial pathology as a result of hormonal imbalance or as a result of malignant histological differentiation, and it may also be used to monitor the response of the endometrium to progestogen treatment.
Halperin
R
R
Department of Obstetrics and Gynecology, Assat Harofeh Medical Center, Zerifin, Israel.
Schneider
D
D
Maymon
R
R
Bukovsky
I
I
Hadas
E
E
D000328:Adult; D000368:Aged; D001826:Body Fluids / Q000737:chemistry*; D004714:Endometrial Hyperplasia / Q000175:diagnosis* / Q000188:drug therapy / Q000378:metabolism; D016889:Endometrial Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis* / Q000378:metabolism; D017258:Medroxyprogesterone Acetate / Q000627:therapeutic use; D008598:Menstruation; D008875:Middle Aged; D009367:Neoplasm Staging; D017698:Postmenopause; D011257:Pregnancy Proteins / Q000032:analysis* / Q000378:metabolism; D014599:Uterus / Q000378:metabolism*
D007136:Immunoglobulins; D011257:Pregnancy Proteins; C088113:decidua-associated protein 200; D017258:Medroxyprogesterone Acetate