The effects of varying dietary n-6 to n-3 fatty acid ratios on platelet reactivity, coagulation screening assays, and antithrombin III activity in dogs.
Thirty beagles were placed on diets containing ratios of n-6 to n-3 fatty acids ranging from 5:1 to 100:1 for 12 weeks to determine the effects of these diets on platelet reactivity, coagulation screening assays, and antithrombin III activity. Although small changes were observed in adenosine diphosphate (ADP)-, collagen-, and arachidonic acid-induced platelet aggregation and 14C-serotonin release, fibrinogen concentrations, and antithrombin III activities during the 12-week study, these changes were not of clinical significance and did not correlate with the varying ratios of n-6 to n-3 fatty acids.
Boudreaux
M K
MK
Department of Pathobiology, College of Veterinary Medicine, Auburn University, Alabama 36849-5519, USA.
Reinhart
G A
GA
Vaughn
D M
DM
Spano
J S
JS
Mooney
M
M
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000818:Animals; D000990:Antithrombin III / Q000032:analysis*; D001095:Arachidonic Acids / Q000494:pharmacology; D001777:Blood Coagulation / Q000187:drug effects* / Q000502:physiology; D001780:Blood Coagulation Tests / Q000379:methods / Q000662:veterinary; D001792:Blood Platelets / Q000187:drug effects* / Q000502:physiology; D002250:Carbon Radioisotopes; D003094:Collagen / Q000494:pharmacology; D004032:Diet / Q000592:standards / Q000662:veterinary; D004042:Dietary Fats, Unsaturated / Q000494:pharmacology*; D004285:Dogs / Q000097:blood* / Q000502:physiology; D015118:Eicosapentaenoic Acid / Q000031:analogs & derivatives / Q000096:biosynthesis; D004837:Epinephrine / Q000494:pharmacology; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage / Q000494:pharmacology*; D043371:Fatty Acids, Omega-6; D005231:Fatty Acids, Unsaturated / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D005340:Fibrinogen / Q000032:analysis; D007975:Leukotriene B4 / Q000031:analogs & derivatives / Q000096:biosynthesis; D008297:Male; D010314:Partial Thromboplastin Time; D010974:Platelet Aggregation / Q000187:drug effects / Q000502:physiology; D010976:Platelet Count / Q000662:veterinary; D011517:Prothrombin Time; D012701:Serotonin / Q000378:metabolism
D001095:Arachidonic Acids; D002250:Carbon Radioisotopes; D004042:Dietary Fats, Unsaturated; D015525:Fatty Acids, Omega-3; D043371:Fatty Acids, Omega-6; D005231:Fatty Acids, Unsaturated; D007975:Leukotriene B4; D012701:Serotonin; D000244:Adenosine Diphosphate; C040212:leukotriene B5; D000990:Antithrombin III; D005340:Fibrinogen; D003094:Collagen; D015118:Eicosapentaenoic Acid; D004837:Epinephrine