Inhibition of CD28-B7 T-cell costimulatory activation pathway affects intragraft cytokine and growth factor expression in chronic renal allograft rejection.
Nadeau
K
K
Surgical Research Laboratory, Harvard Medical School, Boston, Massachusetto 02115, USA.
Azuma
H
H
Chandraker
A
A
Sayegh
M H
MH
Tilney
N L
NL
D000069594:Abatacept; D000818:Animals; D015703:Antigens, CD; D000943:Antigens, Differentiation / Q000627:therapeutic use; D018122:B7-1 Antigen / Q000502:physiology*; D018106:CD28 Antigens / Q000502:physiology*; D060908:CTLA-4 Antigen; D016572:Cyclosporine / Q000627:therapeutic use; D016207:Cytokines / Q000096:biosynthesis*; D006084:Graft Rejection / Q000276:immunology* / Q000628:therapy; D006133:Growth Substances / Q000096:biosynthesis*; D018796:Immunoconjugates; D007165:Immunosuppression Therapy / Q000379:methods; D016030:Kidney Transplantation / Q000276:immunology*; D008213:Lymphocyte Activation; D051381:Rats; D011916:Rats, Inbred F344; D011917:Rats, Inbred Lew; D013601:T-Lymphocytes / Q000276:immunology*; D013997:Time Factors; D014184:Transplantation, Homologous
D015703:Antigens, CD; D000943:Antigens, Differentiation; D018122:B7-1 Antigen; D018106:CD28 Antigens; D060908:CTLA-4 Antigen; D016207:Cytokines; D006133:Growth Substances; D018796:Immunoconjugates; D000069594:Abatacept; D016572:Cyclosporine