Oxidized low density lipoproteins impair peripheral blood mononuclear cell proliferation and cytokine production.
Oxidized low density lipoproteins (ox-LDL) are known to behave as physiological pro-oxidants leading to the formation of intracellular reactive oxygen species. The presence of these altered lipoproteins in the human plasma has been associated with a number of morbid states, including atherosclerosis and immuno-deficiency. Common features of such pathological conditions seem to be represented by several alterations occurring in the immune system. In this work we analyze the in vitro effects of ox-LDL on both proliferative response and cytokine production of normal human peripheral blood mononuclear cells (PBMC). Our results indicate that ox-LDL significantly inhibit proliferative response and modulate cytokine network interfering both at protein secretion and mRNA synthesis level.
Viora
M
M
Department of Immunology, Istituto Superiore di Sanità, Rome, Italy.
Straface
E
E
Di Genova
G
G
Fattorossi
A
A
Rivabene
R
R
Camponeschi
B
B
Masella
R
R
Malorni
W
W
D002455:Cell Division / Q000187:drug effects; D016207:Cytokines / Q000096:biosynthesis* / Q000187:drug effects / Q000235:genetics / Q000378:metabolism; D006801:Humans; D007376:Interleukin-2 / Q000494:pharmacology; D007963:Leukocytes, Mononuclear / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D008077:Lipoproteins, LDL / Q000494:pharmacology*; D008934:Mitogens / Q000494:pharmacology; D010084:Oxidation-Reduction; D012333:RNA, Messenger / Q000096:biosynthesis; D014373:Tuberculin / Q000494:pharmacology
D016207:Cytokines; D007376:Interleukin-2; D008077:Lipoproteins, LDL; D008934:Mitogens; D012333:RNA, Messenger; D014373:Tuberculin; C099252:oxidized low density lipoprotein