Zero interaction response surfaces for combined-action assessment.
Combined-action assessment requires first the calculation of combination effects expected for the case of no interaction. In a second step the experimental combination effects have to be compared to the expected ones in order to classify the combination as synergistic or antagonistic. Adopting the response surface methodology, a new procedure for the calculation of zero interaction response surfaces which can be applied both to various criteria for defining zero interaction and to various types of dose-response relations is proposed. The approach requires only information from single-agent dose-response relations, but provides nevertheless a comprehensive overview over the complete dose range under study. It can replace the tedious isobolographic analysis if the dose-additivity criterion is adopted.
Sühnel
J
J
Institut für Molekulare Biotechnologie, Jena, Germany.
D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D004357:Drug Synergism; D015386:Hazardous Substances / Q000009:adverse effects*; D008956:Models, Chemical; D012044:Regression Analysis
D015386:Hazardous Substances