[The period of termination of nasal symptoms in Japanese cedar pollinosis patients and factors participating in the termination of symptoms].
We investigated when nasal symptoms in 219 patients with cedar pollinosis terminated in 1995. To study factors participating in symptom termination, we examined the rate of positive CAP RAST for antigens other than Japanese cedar in 121 patients, as well as nasal hypersensitivity to histamine and the number of basophilic cells or eosinophils in the surface layer of nasal mucosa in 53 patients before, during and after the Japanese cedar-cypress season. There were peak periods for the termination of nasal symptoms between the end of April and early May. Seventy percent of the patients had symptoms not only during the Japanese cedar season but also during the Japanese cypress season, and 23% of the patients had symptoms that persisted after the Japanese cypress season ended. In the group of patients with persistent symptoms after May date group), the rate of positive CAP RAST for tree pollens other than Japanese cedar or cypress was higher than that in the early group of patients. Moreover in the late group, nasal hypersensitivity to histamine after the season ended remained significantly higher than that in the early group of patients. However, the number of basophilic cells or eosinophils after the season ended showed no significant difference between the early and late groups. In conclusion, sensitization for tree pollens other than Japanese cedar or cypress and nasal hypersensitivity after the season were important factors participating in the termination of nasal symptoms.
Ito
Y
Y
Department of Otorhinolaryngology, Tsu National Hospital.
Takahashi
Y
Y
Matsuura
T
T
Kobayashi
M
M
D000328:Adult; D001491:Basophils / Q000276:immunology; D004804:Eosinophils / Q000276:immunology; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D009297:Nasal Mucosa / Q000276:immunology / Q000503:physiopathology*; D011058:Pollen; D011852:Radioallergosorbent Test; D006255:Rhinitis, Allergic, Seasonal / Q000276:immunology* / Q000503:physiopathology*; D012621:Seasons; D014197:Trees