Exclusion of CAG/CTG trinucleotide repeat loci which map to chromosome 4 in bipolar disorder and schizophrenia.
The hypothesis that expanded trinucleotide repeats contribute to the pathogenesis of schizophrenia and bipolar disorder has been recently supported by three independent studies which have shown that patients with either disorder tend to have larger CAG/CTG repeat expansion detection products than controls. In an attempt to identify the specific expanded CAG/CTG locus or loci which are associated with schizophrenia and bipolar disorder, we determined the repeat size at CAG/CTG loci mapping to candidate regions for psychosis. In this study we report our findings from eight loci which map to chromosome 4. We conclude that these loci are unlikely candidates for CAG/CTG repeat expansion in schizophrenia and bipolar disorder.
Speight
G
G
Division of Psychological Medicine, University of Wales College of Medicine, Cardiff, UK.
Guy
C
C
Bowen
T
T
Asherson
P
P
McGuffin
P
P
Craddock
N
N
Owen
M J
MJ
O'Donovan
M C
MC
D001714:Bipolar Disorder / Q000235:genetics*; D002874:Chromosome Mapping; D002894:Chromosomes, Human, Pair 4; D006801:Humans; D012559:Schizophrenia / Q000235:genetics*; D018911:Trinucleotide Repeats