title: Alteration of left ventricular diastolic function during coronary angioplasty-induced ischemia: a color M-mode Doppler study.
abstract: OBJECTIVE
  The aim of this study was to assess the effects of ischemia on diastolic function by analyzing flow propagation velocity with color M-mode Doppler echocardigraphy.
  
  
  BACKGROUND
  Color M-mode Doppler echocardiography has been proposed as a method of assessing left ventricular filling.
  
  
  METHODS
  Color M-mode Doppler echocardiography and measurement of hemodynamic data were performed simultaneously at baseline and during angioplasty-induced ischemia. Tau was compared with flow propagation velocity. Late diastolic indexes, left ventricular pressure and flow cessation time were also investigated.
  
  
  RESULTS
  During ischemia, left ventricular relaxation rate (tau) increased, whereas flow propagation velocity decreased, from (mean +/- SD) 46.8 +/- 10 ms to 72.6 +/- 18.3 ms and from 59.8 +/- 15.8 cm/s to 30 +/- 8 cm/s, respectively (all p < 0.0001). The maximal slowing of flow propagation velocity was observed 20 to 30 s after the beginning of the inflation, coexisting with a notch on the ascending limb of the negative rate of rise of the left ventricular pressure (dP/dt) curve. Flow propagation velocity was correlated with tau both at baseline (r = 0.53, p < 0.05) and during inflation (r = 0.53, p < 0.03). Left ventricular end-diastolic pressure increased during ischemia from 13.5 +/- 8 mm Hg at baseline to 27.5 +/- 7 mm Hg, while a premature cessation of the entering flow occurred -13.8 +/- 23 ms before the next Q wave onset, compared with 4.5 +/- 19.6 ms after the Q wave onset at baseline (all p < 0.0001).
  
  
  CONCLUSIONS
  The analysis of flow propagation velocity showed that early filling is highly dependent on left ventricular relaxation rate, particularly through the phenomenon of asynchrony. During ischemia, the premature cessation of late filling is associated with increased diastolic pressures.
authors.affiliation: Unité de Recherche U,400 de l'Institut National de la Santé et de la Recherche Médicale, Créteil, France.
authors.forename: A M
authors.initials: AM
authors.lastname: Duval-Moulin
authors.forename: P
authors.initials: P
authors.lastname: Dupouy
authors.forename: P
authors.initials: P
authors.lastname: Brun
authors.forename: F
authors.initials: F
authors.lastname: Zhuang
authors.forename: G
authors.initials: G
authors.lastname: Pelle
authors.forename: Y
authors.initials: Y
authors.lastname: Perez
authors.forename: E
authors.initials: E
authors.lastname: Teiger
authors.forename: A
authors.initials: A
authors.lastname: Castaigne
authors.forename: P
authors.initials: P
authors.lastname: Gueret
authors.forename: J L
authors.initials: JL
authors.lastname: Dubois-Randé
mesh_terms: D015906:Angioplasty, Balloon, Coronary; D001783:Blood Flow Velocity / Q000502:physiology; D006328:Cardiac Catheterization; D003326:Coronary Circulation / Q000502:physiology; D003327:Coronary Disease / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000628:therapy; D003971:Diastole / Q000502:physiology*; D018618:Echocardiography, Doppler, Color; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D012815:Signal Processing, Computer-Assisted; D013318:Stroke Volume / Q000502:physiology; D013997:Time Factors; D016277:Ventricular Function, Left / Q000502:physiology*