Chemoenzymatic synthesis of the Thomsen-Friedenreich antigen determinant.
The efficient chemoenzymatic synthesis of the Thomsen-Friedenreich antigen determinant is demonstrated under transglycosylation conditions employing beta-galactosidase from bovine testes.
Gambert
U
U
Institut für Organische Chemie, Universität Hamburg, Germany.
Thiem
J
J
D000818:Animals; D000951:Antigens, Neoplasm; D015295:Antigens, Tumor-Associated, Carbohydrate / Q000737:chemistry*; D002417:Cattle; D004187:Disaccharides / Q000138:chemical synthesis* / Q000737:chemistry; D000939:Epitopes / Q000737:chemistry*; D006031:Glycosylation; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D015394:Molecular Structure; D013737:Testis / Q000201:enzymology; D001616:beta-Galactosidase
D000951:Antigens, Neoplasm; D015295:Antigens, Tumor-Associated, Carbohydrate; D004187:Disaccharides; D000939:Epitopes; D007202:Indicators and Reagents; C016467:Thomsen-Friedenreich antigen; D001616:beta-Galactosidase