title: Biological characteristics of adrenocortical carcinoma: a study of p53, IGF, EGF-r, Ki-67 and PCNA in 17 adrenocortical carcinomas.
abstract: Adrenocortical carcinoma (ACC) is a rare neoplasm with a poor prognosis. Prognostic factors are needed to identify patients who should be treated aggressively and those for which a less aggressive approach is warranted. As a result of advances within the field of immunohistochemistry, investigations of Ki-67, PCNA, IGF, EGF-r and p53 were performed in 17 ACC. The aim of this study was to clarify the role of Ki-67, PCNA, EGF-r, IGF and p53 in correlation to tumour behaviour and outcome. This retrospective study includes 16 patients, 10 women and 6 men, with a median age of 46 years. Nine tumours were hormonally functioning and 7 were non-functioning. The results obtained revealed that all tumours expressed PCNA and Ki-67 with median values of 59% and 14%, respectively, while p53 was negative in 88%, IGF negative in 82% and EGF-r positive in 94% of the tumours. No correlation was found between p53, IGF, EGF-r and survival rate. There was no interdependence between PCNA and Ki-67, or between PCNA, Ki-67 and the survival rate.
authors.affiliation: Department of Oncology, Akademiska sjukhuset, University Hospital, Uppsala, Sweden.
authors.forename: M
authors.initials: M
authors.lastname: Edgren
authors.forename: B
authors.initials: B
authors.lastname: Eriksson
authors.forename: E
authors.initials: E
authors.lastname: Wilander
authors.forename: J E
authors.initials: JE
authors.lastname: Westlin
authors.forename: S
authors.initials: S
authors.lastname: Nilsson
authors.forename: K
authors.initials: K
authors.lastname: Oberg
mesh_terms: D000306:Adrenal Cortex Neoplasms / Q000737:chemistry* / Q000401:mortality; D000328:Adult; D000368:Aged; D066246:ErbB Receptors / Q000032:analysis*; D005260:Female; D006801:Humans; D019394:Ki-67 Antigen / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D018809:Proliferating Cell Nuclear Antigen / Q000032:analysis*; D012189:Retrospective Studies; D013002:Somatomedins / Q000032:analysis*; D015996:Survival Rate; D016159:Tumor Suppressor Protein p53 / Q000032:analysis*
chemical_list: D019394:Ki-67 Antigen; D018809:Proliferating Cell Nuclear Antigen; D013002:Somatomedins; D016159:Tumor Suppressor Protein p53; D066246:ErbB Receptors