title: [Physiopathology of cerebral circulation].
abstract: Autoregulation of the cerebral circulation is the key mechanism that keeps CBF constant within wide limits of arterial pressure. The mechanism for autoregulation and the influence of arterial hypertension and extracranial carotid stenosis are discussed. Brain function and metabolism are critically dependent on sufficient CBF and oxygen supply. Cerebral ischemia occurs when flow drops below about 10-15 ml/100 g/min. Metabolic and therapeutic aspects of acute cerebral ischemia are discussed.
authors.affiliation: Dipartimento di Medicina Interna e Sanità Publica, Università degli Studi di L'Aquila.
authors.forename: A
authors.initials: A
authors.lastname: Carolei
authors.forename: R
authors.initials: R
authors.lastname: Totaro
authors.forename: M
authors.initials: M
authors.lastname: Baldassarre
mesh_terms: D000208:Acute Disease; D002545:Brain Ischemia / Q000503:physiopathology; D002560:Cerebrovascular Circulation / Q000502:physiology*; D006706:Homeostasis; D006801:Humans