title: Altered postprandial motility in chronic pancreatitis: role of malabsorption.
abstract: OBJECTIVE
  Intraileal nutrients modulate gastrointestinal motility, but effects of maldigestion on postprandial motility are unknown. The aim of this study was to compare motor responses with ileal nutrient exposure in health and pancreatic insufficiency after a meal or intraluminal perfusion.
  
  
  METHODS
  After oroileal multilumen intubation for duodeno-jejuno-ileal sampling, marker perfusion, and motility recording, 14 normal subjects and 12 patients with severe pancreatic insufficiency received a labeled liquid meal twice, either with placebo or pancreatin. Effects of intraileal nutrient perfusion on fed motility induced by duodenal amino acid perfusion were also investigated.
  
  
  RESULTS
  Compared with normals, untreated patients had greater cumulative ileal nutrient delivery (69 +/- 21 vs. 487 +/- 232 kJ), shorter fed pattern (196 +/- 22 vs. 131 +/- 14 minutes), greater 90% gastric emptying (163 +/- 12 vs. 128 +/- 10 minutes), and faster small intestinal transit (86 +/- 9 vs. 44 +/- 6 minutes). Pancreatin reversed these changes. Ileal nutrient perfusion converted fed into interdigestive-like motility in normals (7 of 8) and patients (4 of 5).
  
  
  CONCLUSIONS
  In subjects with pancreatic insufficiency, a low-energy liquid meal induces shorter fed motor pattern associated with accelerated gastric emptying and intestinal transit compared with healthy subjects. Because changes responded to enzyme treatment and could be reproduced by ileal nutrient perfusion, ileal delivery of malabsorbed chyme may be involved as a mechanism.
authors.affiliation: Department of Medicine, Israelitic Hospital, Hamburg, Germany.
authors.forename: P
authors.initials: P
authors.lastname: Layer
authors.forename: M R
authors.initials: MR
authors.lastname: von der Ohe
authors.forename: J J
authors.initials: JJ
authors.lastname: Holst
authors.forename: J B
authors.initials: JB
authors.lastname: Jansen
authors.forename: D
authors.initials: D
authors.lastname: Grandt
authors.forename: G
authors.initials: G
authors.lastname: Holtmann
authors.forename: H
authors.initials: H
authors.lastname: Goebell
mesh_terms: D000328:Adult; D015415:Biomarkers; D001786:Blood Glucose / Q000032:analysis; D002908:Chronic Disease; D004063:Digestion; D004435:Eating; D005260:Female; D005769:Gastrointestinal Motility; D006728:Hormones / Q000097:blood; D006801:Humans; D007408:Intestinal Absorption; D007421:Intestine, Small / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009747:Nutritional Physiological Phenomena; D010194:Pancreatin / Q000627:therapeutic use; D010195:Pancreatitis / Q000378:metabolism* / Q000503:physiopathology*; D012016:Reference Values
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D006728:Hormones; D010194:Pancreatin