Involvement of cytokines in cachexia induced by T-cell leukaemia in the rat.
The objective of this study was to investigate the involvement of cytokines (IL-1, IL-6 and TNF-alpha) in cachexia induced by T-cell leukaemia in the rat. Leukaemic rats exhibited a marked and significant increase in circulating IL-6 concentration from days 12-17 corresponding to the period of weight loss after induction of leukaemia. IL-6 plasma bioactivity correlated significantly with spleen weight and weight loss, implicating IL-6 in the cachectic response. In contrast, IL-1 and TNF-alpha plasma bioactivities were not increased compared to control rats, indicating that these cytokines are not circulating mediators of cachexia induced by T-cell leukaemia in the rat. These data suggest that IL-6 produced by the host may contribute to cachexia induced by T-cell leukaemia.
Roe
S Y
SY
University of Manchester, United Kingdom.
Cooper
A L
AL
Morris
I D
ID
Hopkins
S J
SJ
Rothwell
N J
NJ
D000818:Animals; D002100:Cachexia / Q000209:etiology / Q000378:metabolism*; D007375:Interleukin-1 / Q000097:blood / Q000502:physiology*; D015850:Interleukin-6 / Q000097:blood / Q000502:physiology*; D015458:Leukemia, T-Cell / Q000150:complications / Q000378:metabolism*; D008297:Male; D051381:Rats; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology*
D007375:Interleukin-1; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha