Indomethacin and nordihydroguaiaretic acid inhibition of amyloid beta protein (25-35) activation of phospholipases A2 and D of LA-N-2 cells.
Amyloid beta protein (25-35) stimulates the phospholipase A2, C and D activation of LA-N-2 cells. Nordihydroguaiaretic acid reduced the phospholipase D activation by 30% (P < 0.008) and indomethacin reduced the phospholipase A2 activation by 58% (P < .001). There were no reductions of the amyloid beta protein activations by acetylsalicylic acid (ASA), gentisic acid, sulindac sulfone and acetaminophen. The activation of phospholipase C by amyloid beta protein was unaffected by these compounds.
Singh
I N
IN
Department of Biochemistry and Molecular Biology, University of Manitoba, Winnipeg, Canada.
Sorrentino
G
G
Sitar
D S
DS
Kanfer
J N
JN
D016564:Amyloid beta-Protein Precursor / Q000187:drug effects*; D001932:Brain Neoplasms / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007213:Indomethacin / Q000494:pharmacology*; D009637:Masoprocol / Q000494:pharmacology*; D009447:Neuroblastoma / Q000378:metabolism; D010740:Phospholipases / Q000187:drug effects*; D014407:Tumor Cells, Cultured / Q000187:drug effects
D016564:Amyloid beta-Protein Precursor; D009637:Masoprocol; D010740:Phospholipases; D007213:Indomethacin