title: Mechanism and regulation of transcriptional elongation and termination by RNA polymerase II.
abstract: Over the past year, key advances in several areas of research on the structure and function of the RNA polymerase (pol II) elongation complex have shed considerable light on the mechanisms governing the elongation stage of eukaryotic mRNA synthesis. Novel features of the regulation of elongation by DNA and RNA binding transcriptional activators have been brought to light; the mechanisms of action of elongation factors that suppress pausing and premature arrest by transcribing pol II have been defined in greater detail; and novel elongation factors implicated in human disease have been identified and characterized.
authors.affiliation: Program in Molecular and Cell Biology, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, Oklahoma, 73104, USA.
authors.forename: A
authors.initials: A
authors.lastname: Shilatifard
authors.forename: J W
authors.initials: JW
authors.lastname: Conaway
authors.forename: R C
authors.initials: RC
authors.lastname: Conaway
mesh_terms: D000818:Animals; D006801:Humans; D010441:Peptide Chain Elongation, Translational; D010445:Peptide Elongation Factors / Q000378:metabolism; D012319:RNA Polymerase II / Q000378:metabolism*; D015534:Trans-Activators / Q000378:metabolism; D014158:Transcription, Genetic
chemical_list: D010445:Peptide Elongation Factors; D015534:Trans-Activators; D012319:RNA Polymerase II