Inhibition of human platelet cathepsin A by non-steroidal anti-inflammatory drugs--in vitro study.
Since the lysosomal proteases appear at site of inflammation they may be a target for non-steroidal anti-inflammatory drugs (NSAIDs). In in vitro study the inhibition of human platelet cathepsin A by NSAIDs was found. Indomethacin, phenacetin and aminophenazone were the most potent inhibitors of cathepsin A. Acetylsalicylic acid added to platelet lysate inhibited cathepsin A in the same extent as salicylate. The inhibition was time-dependent and reversed after dialysis. Mixed type of inhibition by salicylate was shown.
Ostrowska
H
H
Department of Instrumental Analysis, Medical Academy, Bialystok, Poland.
D000632:Aminopyrine / Q000494:pharmacology; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001241:Aspirin / Q000494:pharmacology; D001792:Blood Platelets / Q000201:enzymology*; D002268:Carboxypeptidases / Q000037:antagonists & inhibitors* / Q000097:blood; D043402:Cathepsin A; D006801:Humans; D066298:In Vitro Techniques; D007213:Indomethacin / Q000494:pharmacology; D010615:Phenacetin / Q000494:pharmacology; D012459:Salicylates / Q000494:pharmacology; D020156:Salicylic Acid
D000894:Anti-Inflammatory Agents, Non-Steroidal; D012459:Salicylates; D000632:Aminopyrine; D002268:Carboxypeptidases; C468629:CTSA protein, human; D043402:Cathepsin A; D010615:Phenacetin; D020156:Salicylic Acid; D001241:Aspirin; D007213:Indomethacin