title: p53 Protein accumulation is a specific marker of malignant potential in Barrett's metaplasia.
abstract: Our aim was to determine the sensitivity and specificity of p53 accumulation as a marker of malignant potential in Barrett's metaplasia (BM). One hundred eighty biopsies from 61 patients with BM were evaluated for p53 accumulation by immunohistochemistry. Of 25 patients with LGD, 9 had p53-positive biopsies, and of these 5 (56%) developed HGD/CA, whereas 16 had p53-negative biopsies and none (0%) developed HGD/CA after similar follow-up times (P = 0.0108). As a marker of malignant potential in BM, p53 accumulation has a sensitivity of 100%, specificity of 93%, and a predictive value of a positive test of 0.56, compared to sensitivity of 100%, specificity of 64%, and predictive value of a positive test of 0.2 for a histologic diagnosis of LGD. We conclude that: (1) p53 accumulation is more specific and has better predictive value for subsequent development of HGD/CA than histologic diagnosis of LGD. (2) Patients with LGD and p53-positive biopsies are more likely to develop HGD/CA; therefore, they should be followed up more closely than those with LGD and p53-negative biopsies.
authors.affiliation: Department of Pathology, Baylor College of Medicine and the Methodist Hospital, Houston, Texas 77030, USA.
authors.forename: M
authors.initials: M
authors.lastname: Younes
authors.forename: A
authors.initials: A
authors.lastname: Ertan
authors.forename: L V
authors.initials: LV
authors.lastname: Lechago
authors.forename: J R
authors.initials: JR
authors.lastname: Somoano
authors.forename: J
authors.initials: J
authors.lastname: Lechago
mesh_terms: D001471:Barrett Esophagus / Q000150:complications / Q000378:metabolism* / Q000473:pathology; D014408:Biomarkers, Tumor / Q000378:metabolism*; D001706:Biopsy; D002277:Carcinoma / Q000175:diagnosis; D004938:Esophageal Neoplasms / Q000150:complications / Q000175:diagnosis*; D004947:Esophagus / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D008679:Metaplasia; D011230:Precancerous Conditions / Q000378:metabolism; D012680:Sensitivity and Specificity; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; D016159:Tumor Suppressor Protein p53