The toxic oil syndrome: an example of an exogenously induced autoimmune reaction. Toxic oil syndrome.
The toxic oil syndrome (TOS) is a chemically induced autoimmune-like reaction in humans. The etiologic agent(s) have so far not clearly been identified. A short overview is given on this disease which is associated with a unique antibody specificity to cryptic epitopes of C-reactive protein in affected patients. In addition a murine model for TOS is described which suggests that genetic susceptibility might play a role in inducing a similar syndrome in mice. These differences are reflected in the immunological alterations and cytokine production caused by the toxicant.
Bell
S A
SA
Department of Dermatology, Ludwig-Maximilians-University Munich, Germany.
D000814:Aniline Compounds / Q000506:poisoning; D000818:Animals; D001323:Autoantibodies / Q000276:immunology; D001327:Autoimmune Diseases / Q000139:chemically induced / Q000276:immunology*; D015551:Autoimmunity; D002097:C-Reactive Protein / Q000276:immunology*; D005229:Fatty Acids, Monounsaturated; D006801:Humans; D051379:Mice; D010938:Plant Oils / Q000506:poisoning*; D000074262:Rapeseed Oil
D000814:Aniline Compounds; D001323:Autoantibodies; D005229:Fatty Acids, Monounsaturated; D010938:Plant Oils; D000074262:Rapeseed Oil; D002097:C-Reactive Protein