title: MRI study of hepatic tumours following high intensity focused ultrasound surgery.
abstract: High intensity, focused ultrasound has considerable potential as a non-invasive surgical technique, with applications which include the treatment of benign prostatic hyperplasia and the elimination of metastatic disease in the liver. In this study, the use of MRI for treatment planning and subsequent monitoring of ultrasound therapy in the liver has been evaluated. In an experimental model both tumour bearing and normal liver lobes were treated invasively with high intensity focused beam ultrasound surgery. Subsequent changes in the tissue properties were investigated using MRI, in combination with the intravenous contrast agent, Gd-DTPA. The repair of ultrasound damaged tissue was followed until 8 weeks after treatment. The appearance of the MR images was compared with histological sections prepared from parallel experiments. Imaging and histology results showed excellent agreement, illustrating that MRI is well suited to the non-invasive observation of the effects of high intensity focused ultrasound therapy on tissue. Thus, as the clinical potential of ultrasound surgery is realized, MRI, together with the use of contrast agents, will be invaluable both in treatment planning and in monitoring the progress of a treated tumour.
authors.affiliation: CRC Clinical Magnetic Resonance Research Group, Institute of Cancer Research, Sutton, Surrey, UK.
authors.forename: I J
authors.initials: IJ
authors.lastname: Rowland
authors.forename: I
authors.initials: I
authors.lastname: Rivens
authors.forename: L
authors.initials: L
authors.lastname: Chen
authors.forename: C H
authors.initials: CH
authors.lastname: Lebozer
authors.forename: D J
authors.initials: DJ
authors.lastname: Collins
authors.forename: G R
authors.initials: GR
authors.lastname: ter Haar
authors.forename: M O
authors.initials: MO
authors.lastname: Leach
mesh_terms: D000818:Animals; D003287:Contrast Media; D005260:Female; D005354:Fibrosarcoma / Q000175:diagnosis / Q000628:therapy*; D019786:Gadolinium DTPA; D008099:Liver / Q000000981:diagnostic imaging*; D008113:Liver Neoplasms / Q000175:diagnosis / Q000628:therapy*; D008279:Magnetic Resonance Imaging; D009942:Organometallic Compounds; D004369:Pentetic Acid / Q000031:analogs & derivatives*; D051381:Rats; D011919:Rats, Inbred Strains; D016896:Treatment Outcome; D014464:Ultrasonic Therapy / Q000009:adverse effects*; D014463:Ultrasonography
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; D004369:Pentetic Acid; D019786:Gadolinium DTPA