Comparative hypocholesterolemic effects of capybara (Hydrochoerus hydrochaeris dabbenei) oil, horse oil, and sardine oil in cholesterol-fed rats.
The hypocholesterolemic efficacy of various polyunsaturated fatty acids was compared in rats given cholesterol-enriched diets. Capybara oil (CO, linoleic + alpha-linolenic acids), horse oil (HO, alpha-linolenic acid), and sardine oil (SO, eicosapentaenoic + docosahexaenoic acids) were added to diets at 50 g/kg. The weight gain, food intake, and liver weight in the CO-fed group were significantly higher than those in other groups during the 6-wk experimental period. The serum total and very low density lipoprotein (VLDL) + intermediate density lipoprotein (IDL) + low density lipoprotein (LDL) cholesterol concentrations of the CO-fed and SO-fed groups were significantly lower than in the HO-fed group after 6 wk. The serum high density lipoprotein cholesterol concentration in the SO-fed group was significantly higher than that in the CO-fed and HO-fed groups. The fecal neutral sterol concentration in the CO-fed group was reduced significantly compared with the other groups, and the fecal bile acid concentration in the HO-fed group was significantly higher than that in the SO-fed group. The results of this study demonstrate that CO lowers the serum total cholesterol and VLDL + IDL + LDL-cholesterol concentrations in the presence of excess cholesterol in the diet as well as SO.
Fukushima
M
M
Department of Bioresource Chemistry, Obihiro University of Agriculture and Veterinary Medicine, Hokkaido, Japan.
Takayama
Y
Y
Habaguchi
T
T
Nakano
M
M
D000818:Animals; D000924:Anticholesteremic Agents / Q000494:pharmacology*; D001835:Body Weight; D002784:Cholesterol / Q000097:blood*; D002790:Cholesterol 7-alpha-Hydroxylase / Q000378:metabolism; D004041:Dietary Fats / Q000494:pharmacology*; D004281:Docosahexaenoic Acids / Q000494:pharmacology; D015118:Eicosapentaenoic Acid / Q000494:pharmacology; D002149:Energy Intake; D005243:Feces / Q000737:chemistry; D005395:Fish Oils / Q000494:pharmacology*; D005399:Fishes; D006736:Horses; D019787:Linoleic Acid; D008041:Linoleic Acids / Q000494:pharmacology*; D008055:Lipids / Q000737:chemistry; D008099:Liver / Q000201:enzymology; D008297:Male; D009821:Oils / Q000494:pharmacology*; D009929:Organ Size; D051381:Rats; D011916:Rats, Inbred F344; D012377:Rodentia; D017962:alpha-Linolenic Acid / Q000494:pharmacology*
D000924:Anticholesteremic Agents; D004041:Dietary Fats; D005395:Fish Oils; D008041:Linoleic Acids; D008055:Lipids; D009821:Oils; D017962:alpha-Linolenic Acid; D004281:Docosahexaenoic Acids; D002784:Cholesterol; D019787:Linoleic Acid; D015118:Eicosapentaenoic Acid; D002790:Cholesterol 7-alpha-Hydroxylase