Initial experience with collagen-filled Guglielmi detachable coils for endovascular treatment of experimental aneurysms.
OBJECTIVE
To evaluate the effectiveness of Guglielmi detachable coils (GDCs) filled with collagen threads in the permanent treatment of experimental aneurysms.


METHODS
Seventeen side-wall aneurysms were surgically constructed in the canine common carotid artery; six were treated with conventional GDCs and 11 with collagen-filled GDCs. One aneurysms was removed at 1 week, the others were studied by digital subtraction angiography for a period of 8 to 12 weeks. Longitudinal sections of all aneurysms were examined by light microscopy.


RESULTS
Angiograms obtained throughout the follow-up period showed no significant difference between aneurysms treated with conventional GDCs and those treated with collagen-filled GDCs. Light microscopy revealed a dense meshwork of newly formed collagen and fibroblasts near the collagen-filled GDCs, whereas a loose cellular meshwork surrounded the conventional GDCs at 8 and 12 weeks after treatment.


CONCLUSIONS
Collagen threads within GDCs do not noticeably improve angiographic treatment of experimental aneurysms; however, these threads did induce local proliferation of fibroblasts and production of collagen within the aneurysmal cavities.
Szikora
I
I
Stroke Research Institute, Department of Neurosurgery, State University of New York at Buffalo, School of Medicine and Biomedical Sciences 14209, USA.
Wakhloo
A K
AK
Guterman
L R
LR
Chavis
T D
TD
Dawson
R C
RC
Hergenrother
R W
RW
Twyford
R H
RH
Hopkins
L N
LN
D000783:Aneurysm / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy*; D015901:Angiography, Digital Subtraction; D000818:Animals; D002340:Carotid Artery Diseases / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy*; D017536:Carotid Artery, Common / Q000000981:diagnostic imaging / Q000473:pathology; D003094:Collagen / Q000737:chemistry; D003287:Contrast Media; D004285:Dogs; D004621:Embolization, Therapeutic / Q000295:instrumentation*; D004867:Equipment Design; D005347:Fibroblasts / Q000473:pathology; D005500:Follow-Up Studies; D013499:Surface Properties; D014654:Vascular Patency
D003287:Contrast Media; D003094:Collagen