A comparison of patients with major depressive disorder recruited through newspaper advertising versus consultation referrals for clinical drug trials.
Difficulties in recruiting patients for clinical trials have plagued investigators for many years. One concern is the generalizability of clinical trial results to community practice, that is, whether volunteers recruited through advertising are homogeneous with those seeking treatment in a clinical setting. This article retrospectively compares the baseline characteristics of patients recruited through newspaper advertisements with those recruited through consultation referrals by reviewing the charts of 54 patients enrolled in two clinical trials for major depressive disorder (MDD). We examined demographic data, background information, clinical histories, and baseline status. Results indicated homogeneity for most variables. The consultation group was significantly more likely to have had previous treatment for the current episode of depression. These results suggest that, although the advertisement and consultation groups were very similar, the drug naivety of the advertisement group may make them a preferred source in terms of generalizability to community practice.
Miller
C A
CA
Institute of Mental Health Research, Ottawa, Ontario, Canada.
Hooper
C L
CL
Bakish
D
D
D000328:Adult; D002986:Clinical Trials as Topic / Q000592:standards*; D003866:Depressive Disorder / Q000188:drug therapy* / Q000523:psychology; D005260:Female; D006801:Humans; D008297:Male; D009524:Newspapers as Topic; D010361:Patients; D012017:Referral and Consultation; D012189:Retrospective Studies