title: Coyolosa, a new hypoglycemic from Acrocomia mexicana.
abstract: From the methanol extract of the Arocomia mexicana root a new tetrahydropyrane compound was isolated. Its skeletal structure and relative stereochemistry were established by spectral analysis. Substituent effects have been determined with the hope of providing information about steric interactions and conformation of tetrahydropyran derivatives and carbohydrates. The extract showed a significant blood sugar lowering effect on normal and alloxan-diabetic mice when administered at 2.5 to 40 mg/kg i.p. doses, and exhibited a dose-dependent response in the mice models.
authors.affiliation: Universidad Autónoma Metropolitana-Xochimilco, México D.F., Mexico.
authors.forename: S
authors.initials: S
authors.lastname: Pérez
authors.forename: R M
authors.initials: RM
authors.lastname: Pérez
authors.forename: C
authors.initials: C
authors.lastname: Pérez
authors.forename: M A
authors.initials: MA
authors.lastname: Zavala
authors.forename: R
authors.initials: R
authors.lastname: Vargas
mesh_terms: D000818:Animals; D002725:Chloroform / Q000737:chemistry; D006586:Hexanes / Q000737:chemistry; D007004:Hypoglycemic Agents / Q000302:isolation & purification / Q000494:pharmacology*; D000432:Methanol / Q000737:chemistry; D051379:Mice; D008815:Mice, Inbred Strains; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D006586:Hexanes; D007004:Hypoglycemic Agents; D010936:Plant Extracts; D002725:Chloroform; D000432:Methanol