Current research on the immunomodulatory effect of allogeneic blood transfusion.
This review summarizes three aspects of current research on the immunomodulatory effect of allogeneic transfusion. Representatives of three laboratories-each of which is actively engaged in research on transfusion-induced immunomodulation-summarize their current investigative approach. First, current animal models of transfusion-induced immunomodulation are presented and research on the tumor growth-promoting effect of allogeneic transfusion is described. Second, mechanisms underlying an immunomodulatory effect of transfusion are summarized and experiments on the induction of transplant tolerance by selective introduction of donor-type MHC antigens is presented. Third, the potential clinical impact of increased infection and tumor recurrence resulting from transfusion-induced immunomodulation is assessed. The potential role of donor-derived hematopoietic stem cells is presented as an area of future investigation in the area of transfusion-induced immunomodulation.
Dzik
S
S
Deaconess Hospital, Boston, MA 02215, USA.
Blajchman
M A
MA
Blumberg
N
N
Kirkley
S A
SA
Heal
J M
JM
Wood
K
K
D019264:Adoptive Transfer; D000818:Animals; D001769:Blood / Q000276:immunology*; D001803:Blood Transfusion; D005544:Forecasting; D006082:Graft Enhancement, Immunologic; D006801:Humans; D007108:Immune Tolerance / Q000502:physiology; D007519:Isoantigens / Q000276:immunology; D016131:Lymphocyte Subsets / Q000276:immunology; D051379:Mice; D008815:Mice, Inbred Strains; D009362:Neoplasm Metastasis / Q000276:immunology; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology / Q000276:immunology; D065227:Transfusion Reaction; D014181:Transplantation Immunology; D014481:United States / Q000453:epidemiology
D007519:Isoantigens