title: A two-backbone polymer model for interphase chromosome geometry.
abstract: A polymer model for the overall geometric structure of a human chromosome during the G0/G1 portion of cell-cycle interphase is constructed, based on fluorescence in situ hybridization data on distances between defined genomic sequences. The model consists of flexible giant loops, averaging about 6 million base pairs, with two random-walk backbones; it involves essentially three parameters. Numerical results based on properly selected values of parameters fit the data well.
authors.affiliation: Department of Mathematics, College of St. Scholastica, Duluth, MN 55811, USA. bliu@facl.css.edu
authors.forename: B
authors.initials: B
authors.lastname: Liu
authors.forename: R K
authors.initials: RK
authors.lastname: Sachs
mesh_terms: D002877:Chromosomes, Human / Q000235:genetics / Q000648:ultrastructure*; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007399:Interphase; D008433:Mathematics; D008957:Models, Genetic; D011108:Polymers
chemical_list: D011108:Polymers