Remote astroglial response associated with synaptic degeneration results in a net increase of perisynaptic glial fibrillary acidic protein.
Remote astroglial response was evoked in the adult rat visual cortex by unilateral destruction of the corpus geniculatum laterale. Homogenates of ipsi- and contralateral (operated and control) visual cortices were analysed by immunoblotting. A peak increase in glial fibrillary acidic protein (GFAP) was observed 2 weeks after lesion which then declined but did not return to normal showing a time course similar to that of previously observed immunohistochemical changes. Findings prove that the mechanism underlying the enhanced immunoreactivity during remote astroglial response is an up-regulation of GFAP synthesis in the astroglial processes surrounding degenerating synapses.
Hajós
F
F
Department of Anatomy and Histology, University of Veterinary Science, Budapest, Hungary.
Jancsik
V
V
Sótonyi
P
P
D000818:Animals; D001253:Astrocytes / Q000378:metabolism / Q000502:physiology*; D003714:Denervation; D005074:Evoked Potentials, Visual / Q000502:physiology; D005260:Female; D005904:Glial Fibrillary Acidic Protein / Q000096:biosynthesis*; D007150:Immunohistochemistry; D008297:Male; D009410:Nerve Degeneration / Q000502:physiology; D051381:Rats; D013569:Synapses / Q000502:physiology; D015854:Up-Regulation; D014793:Visual Cortex / Q000033:anatomy & histology / Q000378:metabolism / Q000502:physiology
D005904:Glial Fibrillary Acidic Protein