[Specification of cell destiny in early Caenorhabditis elegans embryo].
Embryogenesis of the nematode Caenorhabditis elegans has been described completely on a cell-by-cell basis and found to be essentially invariant. With this knowledge in hands, micromanipulated embryos and mutants have been analyzed for cell lineage defects and the distribution of specific gene products. The results challenge the classical view of cell-autonomous development in nematodes and indicate that the early embryo of C. elegans is a highly dynamic system. A network of inductive events between neighboring cells is being revealed, which is necessary to assign different developmental programs to blastomeres. In those cases where molecules involved in these cell-cell interactions have been identified, homologies to cell surface receptors, ligands and transcription factors found in other systems have become obvious.
Schierenberg
E
E
Zoologisches Institut, Universität Köln, Germany.
D000818:Animals; D017173:Caenorhabditis elegans / Q000196:embryology*; D002455:Cell Division; D004625:Embryo, Nonmammalian / Q000166:cytology* / Q000502:physiology*; D004627:Embryonic Induction