Immunohistochemical demonstration of fibrin II in gastric cancer tissue.
Immunohistochemistry was applied to AMeX-fixed sections of twelve cases of gastric carcinoma obtained at surgical resection to explore the occurrence and distribution of fibrin deposits in situ. Fibrinogen was distributed in abundance throughout perivascular zones and in the connective tissue of the tumor stroma. Fibrin II (des-fibrinopeptide B-type fibrin) was easily identified in a direct apposition to the surface membranes of viable carcinoma cells, predominantly at the host-tumor interface and in the regions immediately adjacent to the zones of angiogenesis. Further studies are required to identify the triggers of the coagulation reactions as well as fibrinolytic system components in the gastric cancer tissue.
Wojtukiewicz
M Z
MZ
Department of Hematology, Medical Academy, Białystok, Poland.
Zimnoch
L
L
Jaromin
J
J
Kłoczko
J
J
Bielawiec
M
M
Matuszewska
E A
EA
D002277:Carcinoma / Q000378:metabolism* / Q000473:pathology; D005337:Fibrin / Q000378:metabolism*; D005340:Fibrinogen / Q000378:metabolism; D005345:Fibrinopeptide B / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D066298:In Vitro Techniques; D013274:Stomach Neoplasms / Q000378:metabolism* / Q000473:pathology
D005345:Fibrinopeptide B; D005337:Fibrin; D005340:Fibrinogen