Effects of flunarizine and nitrendipine on electroconvulsive shock- and clonidine-induced amnesia.
This study was designed to examine the calcium channel blockers flunarizine and nitrendipine for their ability to prevent electroconvulsive shock (ECS)- or clonidine-induced deterioration of the inhibitory avoidance performance (step-down) in rats. Flunarizine (10 mg/kg) and nitrendipine (40 mg/kg) were found to prevent the ECS- or clonidine-provoked amnesia after oral administration for 12 days. The mechanisms of action of the two drugs are considered. The results of this study further suggest that calcium antagonists might be useful in the treatment of cognitive disorders.
Genkova-Papazova
M
M
Laboratory of Pharmacology of the CNS, Bulgarian Academy of Sciences, Sofia, Bulgaria.
Petkova
B P
BP
Lazarova-Bakarova
M
M
Boyanova
E
E
Staneva-Stoytcheva
D
D
D000316:Adrenergic alpha-Agonists / Q000633:toxicity; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D003000:Clonidine / Q000633:toxicity; D004597:Electroshock / Q000009:adverse effects; D005444:Flunarizine / Q000494:pharmacology*; D008297:Male; D008568:Memory / Q000187:drug effects* / Q000502:physiology; D009568:Nitrendipine / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D000316:Adrenergic alpha-Agonists; D002121:Calcium Channel Blockers; D009568:Nitrendipine; D003000:Clonidine; D005444:Flunarizine