title: The effect of strain state on the biostability of a poly(etherurethane urea) elastomer.
abstract: The effect of deformation state on degradation of a PEUU without added stabilizers was examined in an oxidative environment that simulates the in vivo biodegradation of the polymer. Polymer tubes were stressed uniaxially and biaxially over glass mandrels and treated in 20% hydrogen peroxide/0.1 M cobalt chloride solution for 12 days at 37 degrees C. The amount of degradation was determined from the ATR-FTIR peak height of the amorphous aliphatic ether absorbance at 1110 cm-1. If a uniaxial stress was applied, degradation was inhibited and the amount of surface ether remaining after treatment increased linearly with strain. If the stress was biaxial, the amount of degradation was not reduced unless the strain was greater than 200%. Decreased degradation correlated with the amount of soft-segment orientation. The decreased degradation rate was attributed to compaction of the polyether phase by orientation, which resulted in lower permeability to oxidative agents, particularly oxygen. Macroscopic damage was confined to a thin peeling surface layer if the stress was uniaxial. In comparison, biaxially stressed PEUU ruptured.
authors.affiliation: Department of Macromolecular Science, Case Western Reserve University, Cleveland, Ohio 44106-7202, USA.
authors.forename: M A
authors.initials: MA
authors.lastname: Schubert
authors.forename: M J
authors.initials: MJ
authors.lastname: Wiggins
authors.forename: J M
authors.initials: JM
authors.lastname: Anderson
authors.forename: A
authors.initials: A
authors.lastname: Hiltner
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry*; D003035:Cobalt; D004355:Drug Stability; D006861:Hydrogen Peroxide; D007700:Kinetics; D008855:Microscopy, Electron, Scanning; D011140:Polyurethanes / Q000737:chemistry*; D012408:Rubber / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D013314:Stress, Mechanical; D013997:Time Factors
chemical_list: D001672:Biocompatible Materials; D011140:Polyurethanes; D003035:Cobalt; D012408:Rubber; C044690:polyetherurethane urea; D006861:Hydrogen Peroxide; C018021:cobaltous chloride