Cisapride in the prophylaxis of equine post operative ileus.
Cisapride and domperidone were both effective in restoring electrical and mechanical activity, coordination between gastric and small intestinal activity cycles and the stomach to anus transit time in three ponies in which post operative ileus was induced experimentally. Cisapride (0.1 mg/kg bodyweight intramuscularly) for three to eight doses prevented idiopathic post operative ileus in 22 clinical cases requiring colic surgery. The only side effects after cisapride were increased bowel sounds and slight, transient sounds of discomfort. No adverse side effects were seen in 16 cases following anastomosis or enterotomy. Cisapride appears safe and effective in the prophylaxis of equine post operative ileus.
Gerring
E L
EL
Department of Surgery and Obstetrics, Royal Veterinary College, North Mymms, Herts.
King
J N
JN
D000818:Animals; D000932:Antiemetics / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use; D018678:Cholinergic Agents / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D020117:Cisapride; D004294:Domperidone / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects / Q000502:physiology; D006734:Horse Diseases / Q000188:drug therapy / Q000517:prevention & control*; D006736:Horses; D007415:Intestinal Obstruction / Q000188:drug therapy / Q000517:prevention & control / Q000662:veterinary*; D007421:Intestine, Small / Q000187:drug effects / Q000502:physiology; D008297:Male; D010880:Piperidines / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D011183:Postoperative Complications / Q000188:drug therapy / Q000517:prevention & control / Q000662:veterinary*
D000932:Antiemetics; D018678:Cholinergic Agents; D010880:Piperidines; D004294:Domperidone; D020117:Cisapride