Inhibition by L-NA, a nitric oxide synthase inhibitor, of naloxone-precipitated withdrawal signs in a mouse model of cholestasis.
Following the naloxone administration in bile duct resected animals, striking opioid withdrawal signs are observed due to increased opioidergic tone. Pretreatment of animals with L-nitro arginine, a nitric oxide synthase inhibitor, reduces the naloxone-precipitated withdrawal signs as well as increase the antinociception. The results of this study support evidence for the involvement of the L-arg-nitric oxide pathway in opioidergic-dependent manifestation of cholestasis in an animal model.
Ghafourifar
P
P
Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Iran. pedramgf@bc.biol.ethz.ch
Dehpour
A R
AR
Akbarloo
N
N
D000698:Analgesia; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D002779:Cholestasis / Q000150:complications* / Q000378:metabolism; D008297:Male; D051379:Mice; D009270:Naloxone / Q000494:pharmacology*; D009292:Narcotic Antagonists / Q000494:pharmacology*; D019335:Nitroarginine / Q000494:pharmacology*; D018847:Opioid Peptides / Q000502:physiology*; D010147:Pain Measurement; D013375:Substance Withdrawal Syndrome / Q000517:prevention & control*
D009292:Narcotic Antagonists; D018847:Opioid Peptides; D019335:Nitroarginine; D009270:Naloxone