title: Coexistence of tetrasomy 8 and trisomy 8 in a case with myeloid metaplasia with myelofibrosis.
abstract: We present a case of myeloid metaplasia with myelofibrosis (MM/MF), with tetrasomy 8 as the sole cytogenetic abnormality detected by conventional cytogenetic studies. Tetrasomy 8 was also detected by in situ interphase studies and confirmed by chromosome painting in metaphase. To our knowledge, this is the first case of MM/MF with tetrasomy 8. Noteworthy is the association with neurofibromatosis.
authors.affiliation: Laboratori de Citologia Hematologica, Hospital Central l'Aliança, Barcelona, Spain.
authors.forename: F
authors.initials: F
authors.lastname: Solé
authors.forename: J M
authors.initials: JM
authors.lastname: de Pablos
authors.forename: S
authors.initials: S
authors.lastname: Woessner
authors.forename: M M
authors.initials: MM
authors.lastname: Pérez
authors.forename: M
authors.initials: M
authors.lastname: Jurado
authors.forename: B
authors.initials: B
authors.lastname: Espinet
authors.forename: P
authors.initials: P
authors.lastname: Grao
authors.forename: A
authors.initials: A
authors.lastname: Moratalla
authors.forename: J
authors.initials: J
authors.lastname: Esquivias
mesh_terms: D000328:Adult; D002898:Chromosomes, Human, Pair 8; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D017253:Neurofibromatoses / Q000150:complications; D011123:Polyploidy; D055728:Primary Myelofibrosis / Q000150:complications* / Q000235:genetics* / Q000473:pathology; D014314:Trisomy