Decrease in cerebral free magnesium concentration following closed head injury and effects of VA-045 in rats.
1. We examined the alterations in cerebral free Mg2+ concentration in closed head injury (CHI) in rats and the effects of VA-045, a novel apovincaminic acid derivative, on them with in vivo 31P-NMR. 2. Free Mg2+ decreased by about 30% within 20 min after head impact and, afterward, it gradually decreased further to reach about 60% of the control level after 3 hr. VA-045 inhibited the decrease. 3. In nonimpacted rats, VA-045 did not alter the free Mg2+ level. 4. The decrease in cerebral free Mg2+ following CHI may be a critical factor in the development of irreversible tissue injury, and VA-045 may prevent it.
Suzuki
M
M
Department of Pharmacology, Saitama Medical School, Japan.
Nishina
M
M
Endo
M
M
Matsushita
K
K
Tetsuka
M
M
Shima
K
K
Okuyama
S
S
D000818:Animals; D001923:Brain Chemistry; D016489:Head Injuries, Closed / Q000378:metabolism*; D006863:Hydrogen-Ion Concentration; D008274:Magnesium / Q000032:analysis*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D008274:Magnesium