Subretinal fibrosis in central serous chorioretinopathy.
OBJECTIVE
To report unusual and heretofore unreported visually damaging manifestations of severe central serous chorioretinopathy.


METHODS
Case studies.


RESULTS
Each of six male patients (average age, 40 years) had a form of severe central serous chorioretinopathy with at least one eye containing fibrin in the subretinal space that then developed into a subretinal fibrotic scar. Scar formation was followed by a tenting up of the macula, vascularization of the fibrosis (subretinal neovascularization), or a retinal pigment epithelial rip. Four of the seven eyes with subretinal fibrosis had severe visual loss (20/400 or worse).


CONCLUSIONS
Subretinal fibrin and other extracellular matrix molecules appear to stimulate the retinal pigment epithelium to undergo fibrous metaplasia, which results in subretinal fibrotic scar formation and other sequelae, all of which can lead to severe visual loss.
Schatz
H
H
Retina Research Fund, St. Mary's Medical Center, San Francisco, CA, USA.
McDonald
H R
HR
Johnson
R N
RN
Chan
C K
CK
Irvine
A R
AR
Berger
A R
AR
Folk
J C
JC
Robertson
D M
DM
D000328:Adult; D001826:Body Fluids; D015862:Choroid Diseases / Q000150:complications* / Q000473:pathology; D005122:Exudates and Transudates; D005337:Fibrin; D005355:Fibrosis / Q000209:etiology; D005451:Fluorescein Angiography; D005654:Fundus Oculi; D006801:Humans; D008297:Male; D008875:Middle Aged; D012160:Retina / Q000473:pathology*; D012163:Retinal Detachment / Q000209:etiology / Q000473:pathology; D012164:Retinal Diseases / Q000150:complications* / Q000473:pathology; D014786:Vision Disorders / Q000209:etiology; D014792:Visual Acuity
D005337:Fibrin