Ginseng pretreatment protects against transient global cerebral ischemia in the rat: measurement of local cerebral glucose utilization by [14C]deoxyglucose autoradiography.
The effect of ginseng on brain glucose metabolism has been determined in normal and transient cerebral ischemic rat using the autoradiographic [14C]2-deoxyglucose method. Ginseng had no effect on local cerebral glucose utilization (LCGU) in normal rat. By contrast, in rats subjected to 30 min of four vessel occlusion, a significant reduction of LCGU was shown in parts of the cortex and striatum in comparison to the control group. One-week administration of ginseng at 200 mg/kg/d before the occlusion produced an improvement of LCGU compared with the untreated group. These findings indicate that ginseng has some protective effects against brain damage in transient global cerebral ischemia.
Choi
S R
SR
Department of Radiopharmaceutical Chemistry, Faculty of Pharmaceutical Science, Kyoto University, Japan.
Saji
H
H
Iida
Y
Y
Magata
Y
Y
Yokoyama
A
A
D000818:Animals; D001345:Autoradiography; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D002545:Brain Ischemia / Q000188:drug therapy* / Q000378:metabolism; D002250:Carbon Radioisotopes; D003847:Deoxyglucose; D004195:Disease Models, Animal; D005947:Glucose / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D005894:Panax; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal; D051381:Rats; D017208:Rats, Wistar
D002250:Carbon Radioisotopes; D010936:Plant Extracts; D003847:Deoxyglucose; D005947:Glucose