title: Hepatocellular necrosis associated with the subcutaneous injection of an intranasal Bordetella bronchiseptica-canine parainfluenza vaccine.
abstract: A three-year-old wire fox terrier inadvertently was given an intranasal Bordetella bronchiseptica and canine parainfluenza vaccine subcutaneously. The dog subsequently developed both a local inflammatory reaction at the injection site and acute, nonseptic hepatocellular degeneration and necrosis. The patient was treated successfully with intravenous fluids and amikacin. Two months after the injection, the serum bile acid concentrations and hepatic histopathology indicated the presence of continued hepatocellular disease.
authors.affiliation: Department of Medical Sciences, Veterinary of Medical Teaching Hospital, University of Wisconsin-Madison 53706, USA.
authors.forename: K
authors.initials: K
authors.lastname: Toshach
authors.forename: M W
authors.initials: MW
authors.lastname: Jackson
authors.forename: R R
authors.initials: RR
authors.lastname: Dubielzig
mesh_terms: D000281:Administration, Intranasal; D000583:Amikacin / Q000627:therapeutic use; D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001774:Blood Chemical Analysis / Q000662:veterinary; D001885:Bordetella Infections / Q000276:immunology / Q000517:prevention & control / Q000662:veterinary; D016950:Bordetella bronchiseptica / Q000276:immunology*; D004283:Dog Diseases / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D004285:Dogs; D005260:Female; D007279:Injections, Subcutaneous / Q000009:adverse effects / Q000662:veterinary; D008099:Liver / Q000473:pathology*; D008107:Liver Diseases / Q000188:drug therapy / Q000209:etiology / Q000662:veterinary*; D009336:Necrosis; D018184:Paramyxoviridae Infections / Q000276:immunology / Q000517:prevention & control / Q000662:veterinary; D018108:Respirovirus / Q000276:immunology*; D014765:Viral Vaccines / Q000008:administration & dosage / Q000009:adverse effects* / Q000276:immunology
chemical_list: D000900:Anti-Bacterial Agents; D014765:Viral Vaccines; D000583:Amikacin