title: Cyclins, cyclin-dependent kinases and differentiation.
abstract: Cyclin-dependent kinases and their regulatory subunits, the cyclins, are known to regulate progression through the cell cycle. Yet these same proteins are often expressed in non-cycling, differentiated cells. This review surveys the available information about cyclins and cyclin-dependent kinases in differentiated cells and explores the possibility that these proteins may have important functions that are independent of cell cycle regulation.
authors.affiliation: Laboratory of Molecular and Developmental Biology, National Eye Institute, NIH, Bethesda, MD 20892-2730, USA.
authors.forename: C Y
authors.initials: CY
authors.lastname: Gao
authors.forename: P S
authors.initials: PS
authors.lastname: Zelenka
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000502:physiology; D002454:Cell Differentiation / Q000502:physiology*; D018844:Cyclin-Dependent Kinases / Q000145:classification / Q000235:genetics / Q000502:physiology*; D016213:Cyclins / Q000145:classification / Q000235:genetics / Q000502:physiology*; D018507:Gene Expression Regulation, Developmental; D008954:Models, Biological; D005810:Multigene Family; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism; D014158:Transcription, Genetic
chemical_list: D016213:Cyclins; D018844:Cyclin-Dependent Kinases