Toxicities of O-alkyl S-(2-dialkylaminoethyl) methyl phosphonothiolates (V-compounds).
Toxicities expressed as LD50 values of O-alkyl S-(2-dialkylaminoethyl) methyl phosphonothiolates in different species and different routes of administration were determined. Rats were more sensitive to these compounds than mice, rabbits and guinea-pigs were more sensitive than mice and rats. The most sensitive to these compounds were dogs. LD50 values varied in a wide range, however, a decrease of toxicity was observed in the following rank: i.v., i.m., s.c., i.p., p.o. and p.c., respectively. Depending on the route of administration, LD50 values varied from 5 g/kg (i.m., dogs) through tens of microgram/kg for the most part of compounds and routes of administration to hundreds, rarely thousands of g/kg (some chemicals, p.c. administration).
Vachek
J
J
Purkynĕ Military Medical Academy, Hradec Králové.
Gersl
V
V
Fusek
J
J
Krs
O
O
Skopec
F
F
Bajgar
J
J
D000818:Animals; D002619:Chemical Warfare Agents / Q000633:toxicity*; D004285:Dogs; D006168:Guinea Pigs; D051379:Mice; D009946:Organothiophosphorus Compounds / Q000008:administration & dosage / Q000633:toxicity*; D011817:Rabbits; D051381:Rats
D002619:Chemical Warfare Agents; D009946:Organothiophosphorus Compounds