title: The 17p-syndrome: a distinct myelodysplastic syndrome entity?
abstract: The 17p- syndrome is a subset of myelodysplastic syndrome characterized by "typical" dysgranulopoïesis, combining a pseudo-Pelger-Hüet and a deletion of the short arm of chromosome 17. We describe two patients; one with de novo myelodysplastic syndrome (RAEB), one with secondary MDS (RAEB-T). Both showed a 17p- deletion resulting from tanslocations involving 17p associated with an additional complex cytogenetics, and both of them had a particular type of dysgranulopoiesis, combining pseudo-Pelger-Hüet anomaly.
authors.affiliation: Centre Hospitalier V. Dupouy--Sce de Biologie Clinique--Argenteuil, France.
authors.forename: L
authors.initials: L
authors.lastname: Jary
authors.forename: H
authors.initials: H
authors.lastname: Mossafa
authors.forename: C
authors.initials: C
authors.lastname: Fourcade
authors.forename: P
authors.initials: P
authors.lastname: Genet
authors.forename: M
authors.initials: M
authors.lastname: Pulik
authors.forename: G
authors.initials: G
authors.lastname: Flandrin
mesh_terms: D000368:Aged; D002869:Chromosome Aberrations / Q000473:pathology*; D002871:Chromosome Banding; D025063:Chromosome Disorders; D002886:Chromosomes, Human, Pair 17; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000235:genetics* / Q000473:pathology