Aspartate is enriched in sensory cells and subpopulations of non-neuronal cells in the guinea pig inner ear: a quantitative immunoelectron microscopic analysis.
The cellular and subcellular localization of aspartate in the guinea pig inner ear was studied by means of quantitative postembedding cytochemistry. High levels of aspartate immunoreactivity were found in neuronal compartments, including all types of hair cells, and afferent and efferent nerve fibers. In addition, sub-basilar tympanic cells, interdental cells, and the mesothelial cells in the Reissner's membrane were strongly immunoreactive. The present immunocytochemical results are consistent with the idea that aspartate is involved in neurotransmission in the inner ear, but also point to possible metabolic roles of aspartate.
Usami
S
S
Department of Otorhinolaryngology, Hirosaki University School of Medicine, Japan. usami@cc.hirosaki-u.ac.jp
Ottersen
O P
OP
D000818:Animals; D001224:Aspartic Acid / Q000378:metabolism*; D003051:Cochlea / Q000378:metabolism* / Q000648:ultrastructure*; D007758:Ear, Inner / Q000378:metabolism* / Q000648:ultrastructure*; D006168:Guinea Pigs; D007150:Immunohistochemistry; D016253:Microscopy, Immunoelectron
D001224:Aspartic Acid