Treatment of hypertension.
Effectiveness of antihypertensive agents is assessed not only by systemic blood pressure levels, but by multiple parameters that reflect specific organ functions. Among antihypertensive agents, those which inhibit angiotensin actions show particular efficacy in ameliorating end organ damage. This efficacy likely reflects the central role that angiotensin has in regulating renal function by its multifaceted actions. We will therefore focus on the renin angiotensin system, and compare its actions on parameters of renal injury with other antihypertensive treatment approaches.
Fogo
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Department of Pathology, Vanderbilt University Medical Center, Nashville, TN 37232-2165, USA.
Kon
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D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use*; D000818:Animals; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D005919:Glomerular Filtration Rate; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D007674:Kidney Diseases / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D007678:Kidney Glomerulus / Q000187:drug effects* / Q000473:pathology; D011379:Prognosis
D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents