Plasma selenium in healthy man before and after nutratherapy.
Females (n = 28) and males (n = 39) had their plasma analysed for selenium (Se), ubiquinone, alpha-tocopherol (vitamin E), the essential fatty acid (EFA) classes: omega-3 (omega-3, n-3) and omega-6 (omega-6, n-6) fatty acids. Selenium averaged 0.99 +/- 0.03 mumol/l and was positively related to plasma ubiquinone, alpha-tocopherol and the EFA index: the omega-6/omega-3 ratio. Food supplements (nutratherapy) with the lipophilic antioxidants ubiquinone and alpha-tocopherol (Q + E) had no effect on selenium but the addition of omega-3 fatty acids as a fish oil concentrate (Q + E + n-3) had (1.12 +/- 0.05 mumol/l, + 36%, p < 0.001). (Q + E) and (Q + E + n-3) with the addition of selenium (200 micrograms or 2.5 mumol a day) raised selenium but not higher than (Q + E + n-3) itself (1.17 +/- 0.12 mumol/l, p < 0.05). After (Q + E) alone, selenium was related as at base-line to both ubiquinone and alpha-tocopherol but not to any marker for EFA. After (Q + E + n-3), selenium was only related to ubiquinone. An unsatisfactory alpha-tocopherol nutratherapy was suggested as the explanation. EFA or markers for EFA were in no situation related to plasma selenium.
Karlsson
J
J
OBLA AB, Vaxholm, Sweden.
Lundgren
G
G
Rønneberg
R
R
D000328:Adult; D000975:Antioxidants; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage / Q000097:blood; D043371:Fatty Acids, Omega-6; D005231:Fatty Acids, Unsaturated / Q000097:blood; D005260:Female; D005395:Fish Oils / Q000008:administration & dosage; D006801:Humans; D008297:Male; D009747:Nutritional Physiological Phenomena; D012643:Selenium / Q000008:administration & dosage / Q000097:blood*; D014451:Ubiquinone / Q000008:administration & dosage / Q000097:blood; D014810:Vitamin E / Q000008:administration & dosage / Q000097:blood
D000975:Antioxidants; D015525:Fatty Acids, Omega-3; D043371:Fatty Acids, Omega-6; D005231:Fatty Acids, Unsaturated; D005395:Fish Oils; D014451:Ubiquinone; D014810:Vitamin E; D012643:Selenium