Isolation and phylogenetic characterization of Ebola viruses causing different outbreaks in Gabon.
Three outbreaks of Ebola hemorrhagic fever have recently occurred in Gabon. Virus has been isolated from clinical materials from all three outbreaks, and nucleotide sequence analysis of the glycoprotein gene of the isolates and virus present in clinical samples has been carried out. These data indicate that each of the three outbreaks should be considered an independent emergence of a different Ebola virus of the Zaire subtype. As in earlier Ebola virus outbreaks, no genetic variability was detected between virus samples taken during an individual outbreak.
Georges-Courbot
M C
MC
Centre International de Recherches Médicales, Franceville, Gabon.
Sanchez
A
A
Lu
C Y
CY
Baize
S
S
Leroy
E
E
Lansout-Soukate
J
J
Tévi-Bénissan
C
C
Georges
A J
AJ
Trappier
S G
SG
Zaki
S R
SR
Swanepoel
R
R
Leman
P A
PA
Rollin
P E
PE
Peters
C J
CJ
Nichol
S T
ST
Ksiazek
T G
TG
D000818:Animals; D018420:Ape Diseases / Q000473:pathology / Q000821:virology; D004196:Disease Outbreaks; D029043:Ebolavirus / Q000235:genetics* / Q000302:isolation & purification* / Q000472:pathogenicity; D005681:Gabon / Q000453:epidemiology; D005814:Genes, Viral; D014644:Genetic Variation; D006023:Glycoproteins / Q000235:genetics; D019142:Hemorrhagic Fever, Ebola / Q000453:epidemiology* / Q000662:veterinary / Q000821:virology*; D006801:Humans; D002679:Pan troglodytes; D010802:Phylogeny; D012367:RNA, Viral / Q000235:genetics / Q000302:isolation & purification; D014764:Viral Proteins / Q000235:genetics; D015678:Viral Structural Proteins / Q000235:genetics
D006023:Glycoproteins; D012367:RNA, Viral; D014764:Viral Proteins; D015678:Viral Structural Proteins