title: Clinical, pathological and molecular genetic findings in small intestinal follicle centre cell lymphoma.
abstract: A 44-year-old male was evaluated for an iron deficiency anemia. Endoscopic investigation revealed marked serpiginous ulceration of the proximal small intestine due to a B cell lymphoma. Endoscopic small intestinal mucosal biopsies revealed a nodular lymphoid infiltrate, and polymerase chain reaction of biopsy material from the same site demonstrated rearrangement of the bcl-2 gene, the molecular equivalent of the t(14;18) chromosomal translocation. Primary small bowel follicular small cleaved cell lymphoma was diagnosed. Endoscopic tissue biopsies for immunophenotyping, molecular genetic studies or both are a valuable diagnostic aid for precise classification of lymphoid neoplasms in the gastrointestinal tract.
authors.affiliation: Department of Medicine (Gastroenterology), University of British Columbia, Vancouver.
authors.forename: H J
authors.initials: HJ
authors.lastname: Freeman
authors.forename: M E
authors.initials: ME
authors.lastname: Anderson
authors.forename: R D
authors.initials: RD
authors.lastname: Gascoyne
mesh_terms: D000328:Adult; D018798:Anemia, Iron-Deficiency / Q000175:diagnosis / Q000503:physiopathology; D001706:Biopsy; D003937:Diagnosis, Differential; D016099:Endoscopy, Gastrointestinal; D005753:Gastric Mucosa / Q000473:pathology; D019254:Genes, bcl-2 / Q000235:genetics; D006801:Humans; D007421:Intestine, Small / Q000473:pathology; D016393:Lymphoma, B-Cell / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology*; D008224:Lymphoma, Follicular / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology*; D008297:Male; D016133:Polymerase Chain Reaction; D014057:Tomography, X-Ray Computed