title: Spontaneous corneal rupture in Noonan syndrome. A case report.
abstract: OBJECTIVE
  A variety of ocular and periocular manifestations have been described in Noonan syndrome. Collagen abnormalities have been described; however, to our knowledge spontaneous corneal rupture has not been reported. A forty-three-year-old female who presented with spontaneous corneal rupture was later diagnosed as having Noonan syndrome.
  
  
  CONCLUSIONS
  Collagen abnormalities have been described with Noonan syndrome and this is likely the cause of corneal rupture in this patient.
authors.affiliation: Department of Ophthalmology, Louisiana State University Medical School- Shreveport 71130-3932, USA.
authors.forename: Y K
authors.initials: YK
authors.lastname: Au
authors.forename: W P
authors.initials: WP
authors.lastname: Collins
authors.forename: J S
authors.initials: JS
authors.lastname: Patel
authors.forename: A
authors.initials: A
authors.lastname: Asamoah
mesh_terms: D000328:Adult; D003094:Collagen / Q000378:metabolism; D003315:Cornea / Q000473:pathology*; D003316:Corneal Diseases / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D009634:Noonan Syndrome / Q000150:complications* / Q000235:genetics / Q000378:metabolism; D010375:Pedigree; D012422:Rupture, Spontaneous / Q000209:etiology / Q000473:pathology / Q000601:surgery; D014792:Visual Acuity
chemical_list: D003094:Collagen