title: Immunohistochemical colocalization of GTP cyclohydrolase I in the nigrostriatal system with tyrosine hydroxylase.
abstract: Immunohistochemical colocalization of GTP cyclohydrolase I (GCH) in the mouse nigrostriatal system with tyrosine hydroxylase or aromatic L-amino acid decarboxylase in the somata and terminals of GCH-positive catecholaminergic neurons are proved for the first time by a double-labeling immunofluorescence method with a confocal laser-scanning microscope. GCH-immunoreactive somata in the mouse substantia nigra have synaptic contacts with monoaminergic and non-monoaminergic terminals.
authors.affiliation: Department of Anatomy, School of Medicine, Fujita Health University, Aichi, Japan.
authors.forename: I
authors.initials: I
authors.lastname: Nagatsu
authors.forename: R
authors.initials: R
authors.lastname: Arai
authors.forename: M
authors.initials: M
authors.lastname: Sakai
authors.forename: Y
authors.initials: Y
authors.lastname: Yamawaki
authors.forename: T
authors.initials: T
authors.lastname: Takeuchi
authors.forename: N
authors.initials: N
authors.lastname: Karasawa
authors.forename: T
authors.initials: T
authors.lastname: Nagatsu
mesh_terms: D000818:Animals; D006136:GTP Cyclohydrolase / Q000378:metabolism*; D007150:Immunohistochemistry; D008297:Male; D051379:Mice; D008854:Microscopy, Electron; D013378:Substantia Nigra / Q000201:enzymology* / Q000648:ultrastructure; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism*; D014793:Visual Cortex / Q000201:enzymology* / Q000648:ultrastructure
chemical_list: D014446:Tyrosine 3-Monooxygenase; D006136:GTP Cyclohydrolase