Molecular mimicry between Helicobacter pylori and the host.
Helicobacter pylori lipopolysaccharide (LPS) expresses Lewis x and Lewis y blood group antigens that are identical to those occurring in the human gastric mucosa. During infection, antibodies against LPS, which bind to host Lewis antigens, may be induced. These consequently recognize gastric glycoprotein targets and cause autoimmune inflammation.
Appelmelk
B J
BJ
Dept of Medical Microbiology, Vrije Universiteit, Amsterdam, The Netherlands. bj.appelmelk.mm@med.vu.nl
Negrini
R
R
Moran
A P
AP
Kuipers
E J
EJ
D000818:Animals; D000911:Antibodies, Monoclonal / Q000096:biosynthesis; D001323:Autoantibodies / Q000096:biosynthesis; D001426:Bacterial Proteins / Q000235:genetics / Q000276:immunology; D005753:Gastric Mucosa / Q000276:immunology; D016481:Helicobacter Infections / Q000209:etiology / Q000276:immunology / Q000473:pathology; D016480:Helicobacter pylori / Q000235:genetics / Q000276:immunology* / Q000472:pathogenicity; D006801:Humans; D007983:Lewis Blood Group Antigens / Q000276:immunology; D008070:Lipopolysaccharides / Q000276:immunology; D051379:Mice; D018716:Molecular Mimicry
D000911:Antibodies, Monoclonal; D001323:Autoantibodies; D001426:Bacterial Proteins; D007983:Lewis Blood Group Antigens; D008070:Lipopolysaccharides