5-benzyloxy-2-thiocyanatomethyl-4-pyranone, a novel heterocyclic compound: synthesis, structure determination and effects on neoplastic cell growth.
The present study was undertaken to prepare a novel 4-pyranone compound 5-benzylaxy-2-thiocyanatomethyl-4-pyranone as well as to investigate its effects on neoplastic cell growth. Three cell lines (murine leukemia L1210, human leukemia K562 and rat pituitary GH4C1 cells) were used in our experiments. The cell growth, DNA, RNA, protein synthesis, and cytoplasmatic protein phosphorylation after the treatment of GH4C1 cells with 5-benzyloxy-2-thiocyanatomethyl-4-pyranone were investigated. We found that the above new 4-pyranone derivative at 2.6 microM significantly (p < 0.05) inhibits neoplastic cell growth, and inhibits (p < 0.05) DNA synthesis.
Bransová
J
J
Institute of Experimental Endocrinology, Slovak Academy of Sciences, Bratislava, Slovak Republic.
Uher
M
M
Novotný
L
L
Brtko
J
J
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D004247:DNA / Q000096:biosynthesis; D006801:Humans; D007939:Leukemia L1210 / Q000188:drug therapy; D010766:Phosphorylation; D011753:Pyrones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D051381:Rats; D013861:Thiocyanates / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D011753:Pyrones; D013861:Thiocyanates; C105766:5-benzyloxy-2-thiocyanatomethyl-4-pyranone; D004247:DNA