Indirect bright light improves circadian rest-activity rhythm disturbances in demented patients.
Light is known to be an important modulator of circadian rhythms. We tested the hypothesis than an enduring increase in the daytime environmental illumination level improves rest-activity rhythm disturbances in demented patients. Actigraphy was performed before, during, and after 4 weeks of increased illumination in the living rooms of 22 patients with dementia clinically diagnosed as probable Alzheimer's disease, multi-infarct dementia, dementia associated with alcoholism, or normal pressure hydrocephalus. The results indicated that during increased illumination, the stability of the rest-activity rhythm increased in patients with intact vision, but not in visually impaired patients.
Van Someren
E J
EJ
Graduate School of Neurosciences Amsterdam, Netherlands.
Kessler
A
A
Mirmiran
M
M
Swaab
D F
DF
D000368:Aged; D000369:Aged, 80 and over; D000437:Alcoholism / Q000150:complications; D000544:Alzheimer Disease / Q000628:therapy*; D002940:Circadian Rhythm; D003704:Dementia / Q000628:therapy*; D015161:Dementia, Multi-Infarct / Q000628:therapy; D005260:Female; D015577:Geriatric Assessment; D006801:Humans; D006850:Hydrocephalus, Normal Pressure / Q000150:complications; D008297:Male; D008875:Middle Aged; D010789:Phototherapy; D012890:Sleep; D012931:Social Environment; D016896:Treatment Outcome; D014851:Wakefulness