Peripheral neuroepithelioma (peripheral primitive neuroectodermal tumor) of the uterine cervix.
We report here a case of peripheral neuroepithelioma arising in the uterine cervix. A 44-year-old female had complained of irregular genital bleeding for several months and was diagnosed as extraosseous Ewing's sarcoma (EOE) from biopsy specimens initially. The tumor cells, which were intensely stained by periodic acid-Schiff (PAS) and digested with diastase, were uniformly small and round, had hyperchromatic nuclei and scant, indistinct cytoplasm. The surgically-removed tumor cells were immunohistochemically stained with antisera against neuro-specific enolase (NSE), tyrosine hydroxylase. In ultrastructural study, neurosecretory granules were observed. Finally we diagnosed this case as peripheral neuroepithelioma (peripheral primitive neuroectodermal tumor, PNET).
Sato
S
S
Department of Obstetrics and Gynecology, Tohoku University School of Medicine, Sendai, Japan.
Yajima
A
A
Kimura
N
N
Namiki
T
T
Furuhashi
N
N
Sakuma
H
H
D000328:Adult; D001706:Biopsy; D004396:Coloring Agents; D003594:Cytoplasmic Granules / Q000473:pathology / Q000648:ultrastructure; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D018241:Neuroectodermal Tumors, Primitive, Peripheral / Q000473:pathology* / Q000601:surgery / Q000648:ultrastructure; D010751:Phosphopyruvate Hydratase / Q000032:analysis; D012512:Sarcoma, Ewing / Q000473:pathology; D014446:Tyrosine 3-Monooxygenase / Q000032:analysis; D002583:Uterine Cervical Neoplasms / Q000473:pathology* / Q000601:surgery / Q000648:ultrastructure
D004396:Coloring Agents; D014446:Tyrosine 3-Monooxygenase; D010751:Phosphopyruvate Hydratase