The enigma of pyloric stenosis. Some thoughts on the aetiology.
A theory is advanced about the cause of pyloric stenosis of infancy (PS). Developmental changes will conspire to produce pathogenetic gastric hyperacidity within the first 4 weeks of life in babies who develop PS. The prime cause will be an increased gastric acidity due to a genetically determined supernormal parietal cell mass. This theory satisfactorily explains many known clinical features.
Rogers
I M
IM
South Tyneside Health Care Trust, South Shields, Tyne and Wear, UK.
D000367:Age Factors; D005260:Female; D005744:Gastric Acid / Q000378:metabolism*; D005755:Gastrins / Q000097:blood; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D010295:Parietal Cells, Gastric / Q000473:pathology; D011707:Pyloric Stenosis / Q000453:epidemiology / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D012307:Risk Factors; D013997:Time Factors
D005755:Gastrins