title: Endocrinological and clinical analysis of hyperprolactinemic patients with and without ultrasonically diagnosed polycystic ovarian changes.
abstract: In the present study we aimed to identify the relationship of hyperprolactinemia and polycystic ovarian changes. We retrospectively analyzed the endocrinological and clinical features of 79 hyperprolactinemic patients detected during a 3-year period ending in March 1995. Patients who had hypothyroidism, macroprolactinoma and drug-induced hyperprolactinemia were excluded from the study. Among 61 hyperprolactinemic patients, 41 (67.2%) had ultrasonographically diagnosed polycystic ovaries (PCO). Prolactin levels in the PCO and non-PCO groups were 32.8 +/- 5.8 and 36.7 +/- 5.1 ng/dl, respectively, which was a significant difference (p < 0.05). Hirsutism was associated with hyperprolactinemia in 55.7% of the patients and was found to be more frequent in the PCO (58.8%) than the non-PCO group (41.2%). The mean Ferriman Gallwey scores and both total and free testosterone levels were significantly higher in the PCO group in comparison to the non-PCO group. In addition, a significantly higher body mass index was detected in patients with PCO. We documented a frequent association between hyperprolactinemia and polycystic ovarian changes and suggested that hyperprolactinemia in PCO is most likely related to a pathologic-endocrinologic milieu.
authors.affiliation: Department of Reproductive Endocrinology, IVF-ET Clinic, Dr. Zekai Tahir Burak Women's Hospital, Ankara, Turkey.
authors.forename: A Z
authors.initials: AZ
authors.lastname: Işik
authors.forename: B
authors.initials: B
authors.lastname: Gülekli
authors.forename: C G
authors.initials: CG
authors.lastname: Zorlu
authors.forename: T
authors.initials: T
authors.lastname: Ergin
authors.forename: O
authors.initials: O
authors.lastname: Gökmen
mesh_terms: D000568:Amenorrhea / Q000209:etiology; D015992:Body Mass Index; D005260:Female; D006628:Hirsutism / Q000150:complications; D006801:Humans; D006966:Hyperprolactinemia / Q000097:blood / Q000150:complications*; D007986:Luteinizing Hormone / Q000097:blood; D009839:Oligomenorrhea / Q000209:etiology; D011085:Polycystic Ovary Syndrome / Q000150:complications* / Q000000981:diagnostic imaging*; D012189:Retrospective Studies; D013739:Testosterone / Q000097:blood; D014463:Ultrasonography
chemical_list: D013739:Testosterone; D007986:Luteinizing Hormone