Ether lipid metabolism, GPI anchor biosynthesis, and signal transduction are putative targets for anti-leishmanial alkyl phospholipid analogues.
Lux
H
H
King's College London, United Kingdom.
Hart
D T
DT
Parker
P J
PJ
Klenner
T
T
D000818:Animals; D000981:Antiprotozoal Agents / Q000494:pharmacology*; D017261:Glycosylphosphatidylinositols / Q000096:biosynthesis*; D007527:Isoenzymes / Q000037:antagonists & inhibitors / Q000378:metabolism; D007894:Leishmania mexicana / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D007928:Lethal Dose 50; D050356:Lipid Metabolism; D010743:Phospholipids / Q000494:pharmacology*; D011493:Protein Kinase C / Q000037:antagonists & inhibitors / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects*
D000981:Antiprotozoal Agents; D017261:Glycosylphosphatidylinositols; D007527:Isoenzymes; D010743:Phospholipids; D011493:Protein Kinase C