Expression and in-vivo modulation of alpha- and beta-adrenoceptors on human natural killer (CD16+) cells.
Expression and in-vivo modulation of beta- and alpha-adrenoceptors on peripheral human natural killer (CD16+) cells was investigated. Ligand binding studies revealed that CD16+ lymphocytes express beta2, alpha1-, alpha2- but not beta1-adrenoceptors. Infusion of adrenaline, but not noradrenaline, significantly decreased beta2- and alpha1-adrenoceptor numbers on NK cells. Both catecholamines did not appreciably alter alpha2-adrenoceptor numbers. Additional analyses showed that adrenaline administration increases alpha2-adrenoceptor numbers on peripheral mononuclear blood cells (PBMC) and T-cell subsets (CD4+, CD8+) in contrast to decreased receptor numbers on CD16+ cells. These data demonstrate a specific effect of increasing levels of circulating catecholamines on beta2-adrenoceptors on NK cells.
Jetschmann
J U
JU
Division of Clinical Immunology, Hannover Medical School, Germany.
Benschop
R J
RJ
Jacobs
R
R
Kemper
A
A
Oberbeck
R
R
Schmidt
R E
RE
Schedlowski
M
M
D000322:Adrenergic Agonists / Q000494:pharmacology; D000316:Adrenergic alpha-Agonists / Q000494:pharmacology; D000328:Adult; D015704:CD4 Antigens / Q000032:analysis; D016827:CD8 Antigens / Q000032:analysis; D004837:Epinephrine / Q000494:pharmacology; D006801:Humans; D007694:Killer Cells, Natural / Q000187:drug effects / Q000276:immunology / Q000378:metabolism*; D008297:Male; D009000:Monocytes / Q000187:drug effects / Q000378:metabolism; D009638:Norepinephrine / Q000494:pharmacology; D011942:Receptors, Adrenergic, alpha / Q000378:metabolism*; D011943:Receptors, Adrenergic, beta / Q000378:metabolism*; D017452:Receptors, IgG / Q000032:analysis; D016176:T-Lymphocyte Subsets / Q000187:drug effects / Q000378:metabolism
D000322:Adrenergic Agonists; D000316:Adrenergic alpha-Agonists; D015704:CD4 Antigens; D016827:CD8 Antigens; D011942:Receptors, Adrenergic, alpha; D011943:Receptors, Adrenergic, beta; D017452:Receptors, IgG; D009638:Norepinephrine; D004837:Epinephrine