title: A study of tolerance in a concordant xenograft model.
abstract: Antibody-mediated rejection appears to constitute the major difference between concordant xenografts and allografts in nonhuman primates. Consistent with its known effect on antibody responses, 5-7 addition of DSG to the conditioning regimen has extended concordant primate xenograft survival for up to 6 months after discontinuation of conventional immunosuppression. In contrast to our observations in recipients of renal allografts, donor-specific skin graft rejection can occur and even in long-term recipients may induce rejection of a previously accepted renal xenograft.
authors.affiliation: Transplant Unit, Massachusetts General Hospital, Boston, USA.
authors.forename: A M
authors.initials: AM
authors.lastname: Bartholomew
authors.forename: A B
authors.initials: AB
authors.lastname: Cosimi
authors.forename: D H
authors.initials: DH
authors.lastname: Sachs
authors.forename: M
authors.initials: M
authors.lastname: Bailin
authors.forename: S
authors.initials: S
authors.lastname: Boskovic
authors.forename: R
authors.initials: R
authors.lastname: Colvin
authors.forename: H
authors.initials: H
authors.lastname: Hong
authors.forename: M
authors.initials: M
authors.lastname: Johnson
authors.forename: M
authors.initials: M
authors.lastname: Kimikawa
authors.forename: A
authors.initials: A
authors.lastname: Leguern
authors.forename: S
authors.initials: S
authors.lastname: Meehan
authors.forename: T
authors.initials: T
authors.lastname: Sablinski
authors.forename: S L
authors.initials: SL
authors.lastname: Wee
authors.forename: J
authors.initials: J
authors.lastname: Powelson
mesh_terms: D000818:Animals; D000910:Antibodies, Heterophile / Q000097:blood; D000917:Antibody Formation; D000961:Antilymphocyte Serum / Q000627:therapeutic use; D016026:Bone Marrow Transplantation / Q000276:immunology*; D016572:Cyclosporine / Q000494:pharmacology; D006084:Graft Rejection / Q000276:immunology*; D006085:Graft Survival; D006146:Guanidines / Q000494:pharmacology; D007111:Immunity, Cellular; D007074:Immunoglobulin G / Q000097:blood; D007165:Immunosuppression Therapy / Q000379:methods; D007166:Immunosuppressive Agents / Q000494:pharmacology; D016030:Kidney Transplantation / Q000276:immunology*; D008252:Macaca fascicularis; D010215:Papio; D013156:Splenectomy; D013950:Thymus Gland / Q000528:radiation effects; D014183:Transplantation, Heterologous / Q000276:immunology* / Q000473:pathology; D014916:Whole-Body Irradiation
chemical_list: D000910:Antibodies, Heterophile; D000961:Antilymphocyte Serum; D006146:Guanidines; D007074:Immunoglobulin G; D007166:Immunosuppressive Agents; D016572:Cyclosporine; C037258:gusperimus