title: Neuronal injury in experimental status epilepticus in the rat: role of acidosis.
abstract: Systemic and cerebral acidosis accompanies generalized tonic-clonic seizures and status epilepticus. Acidosis during status may be modified by neuromuscular paralysis, intubation and ventilation, or administration of a base, but the effect of acidosis on neuronal injury from status is uncertain. We studied the effect of acidosis, induced by hypercarbic ventilation, on heat-shock protein (HSP72) induction in rat brain as a measure of neuronal injury in experimental status epilepticus. Acidosis was found to attenuate neuronal injury, independent of its anticonvulsant effect.
authors.affiliation: Department of Neurology, University of Pittsburgh Medical School, PA 15213, USA.
authors.forename: M
authors.initials: M
authors.lastname: Sasahira
authors.forename: T
authors.initials: T
authors.lastname: Lowry
authors.forename: R P
authors.initials: RP
authors.lastname: Simon
mesh_terms: D000138:Acidosis / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000378:metabolism*; D004195:Disease Models, Animal; D006360:Heat-Shock Proteins / Q000378:metabolism*; D007150:Immunohistochemistry; D008297:Male; D009474:Neurons / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013226:Status Epilepticus / Q000378:metabolism*
chemical_list: D006360:Heat-Shock Proteins