title: Cancer mortality in a Chinese population exposed to hexavalent chromium in water.
abstract: This report is a clarification and further analysis of our previously published mortality study regarding groundwater contamination with hexavalent chromium (Cr+6) in the JinZhou area of China between 1965 and 1978. In our previous report, we stated that a significant excess of overall cancer mortality was observed (P = 0.04) in five Cr(+6)-contaminated villages combined. Further analysis revealed no clear statistical increase in cancer mortality in the three villages adjacent to the source of the contamination (P = 0.25), where 57% of the wells exceeded the European Community safe drinking water standard of 0.05 ppm Cr+6. These results do not indicate an association of cancer mortality with exposure to Cr(+6)-contaminated groundwater, but might reflect the influence of lifestyle or environmental factors not related to Cr+6. Further follow-up of this cohort is recommended.
authors.affiliation: JinZhou Health and Anti-Epidemic Station, JinZhou City, Liao-Ning Province, China.
authors.forename: J D
authors.initials: JD
authors.lastname: Zhang
authors.forename: S
authors.initials: S
authors.lastname: Li
mesh_terms: D002274:Carcinogens, Environmental / Q000009:adverse effects*; D002681:China / Q000453:epidemiology; D002857:Chromium / Q000009:adverse effects* / Q000032:analysis; D006801:Humans; D008175:Lung Neoplasms / Q000401:mortality; D009369:Neoplasms / Q000453:epidemiology / Q000401:mortality*; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000401:mortality; D014873:Water Pollutants / Q000009:adverse effects* / Q000032:analysis; D014881:Water Supply / Q000032:analysis
chemical_list: D002274:Carcinogens, Environmental; D014873:Water Pollutants; D002857:Chromium; C074702:chromium hexavalent ion