title: Pharmaceutical properties of freeze-dried formulations of egg albumin, several drugs and olive oil.
abstract: The freeze-dried ternary formulations of meclizine (MZ, an anti-motion sickness drug), prednisolone (PRED, an anti-inflammatory drug) and norfloxacin (NFLX, an anti-microbial drug) which are poorly water-soluble and are low bioavailability drugs, were prepared using egg albumin and olive oil. The powder X-ray diffractions, the dissolution rate and the bioavailabilities in vivo of these formulations were studied in comparison with each drug alone. By forming ternary formulations of these drugs, the dissolution rates of the drugs from the formulations were significantly improved compared with each drug alone. The results of their powder X-ray diffraction measurements showed that these drugs in the ternary formulations presented in an amorphous form, indicating increased dissolution rates. On the other hand, the plasma concentrations of these drugs increased significantly after oral administration in formulations to rats, except for the NFLX formulation, and the areas under the concentration-time curves (AUC) of the ternary formulations of MZ, PRED and NFLX were 2.1, 1.6 and 1.3 times those of the drugs alone, respectively. From these results, it was proven that formulations consisting of egg albumin, olive oil and poorly water-soluble drugs were useful preparations for improving the drug's disadvantageous pharmaceutical properties.
authors.affiliation: Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Tsuji
authors.forename: H
authors.initials: H
authors.lastname: Kakegawa
authors.forename: H
authors.initials: H
authors.lastname: Miyataka
authors.forename: M
authors.initials: M
authors.lastname: Nishiki
authors.forename: H
authors.initials: H
authors.lastname: Matsumoto
authors.forename: T
authors.initials: T
authors.lastname: Satoh
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000890:Anti-Infective Agents / Q000378:metabolism / Q000493:pharmacokinetics*; D000893:Anti-Inflammatory Agents / Q000378:metabolism / Q000493:pharmacokinetics*; D000932:Antiemetics / Q000378:metabolism / Q000493:pharmacokinetics*; D001682:Biological Availability; D001702:Biopharmaceutics; D002626:Chemistry, Pharmaceutical; D002851:Chromatography, High Pressure Liquid; D004339:Drug Compounding; D005612:Freeze Drying; D008297:Male; D008468:Meclizine / Q000378:metabolism / Q000493:pharmacokinetics*; D015394:Molecular Structure; D009643:Norfloxacin / Q000378:metabolism / Q000493:pharmacokinetics*; D000069463:Olive Oil; D010047:Ovalbumin; D010938:Plant Oils; D011239:Prednisolone / Q000378:metabolism / Q000493:pharmacokinetics*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012995:Solubility; D014961:X-Ray Diffraction
chemical_list: D000890:Anti-Infective Agents; D000893:Anti-Inflammatory Agents; D000932:Antiemetics; D000069463:Olive Oil; D010938:Plant Oils; D008468:Meclizine; D010047:Ovalbumin; D011239:Prednisolone; D009643:Norfloxacin