Stimulation of NF-kappa B activation and gene expression by platelet-activating factor.
PAF stimulation of NF-kappa B activation and transcription of immediate-early genes have been investigated in peripheral blood mononuclear cells and in transfected Chinese hamster ovary cells expressing the cloned PAF receptor. These studies identified a G protein-coupled pathway for PAF induction of gene expression and transcription factor activation, which differs from the mechanisms employed by other immediate-early gene inducers. Potential significance of PAF induced NF-kappa B activation is discussed.
Ye
R D
RD
Department of Immunology, Scripps Research Institute, La Jolla, California 92037, USA.
Kravchenko
V V
VV
Pan
Z
Z
Feng
L
L
D000818:Animals; D016466:CHO Cells; D006224:Cricetinae; D015870:Gene Expression / Q000187:drug effects*; D005786:Gene Expression Regulation / Q000187:drug effects; D006801:Humans; D051379:Mice; D016328:NF-kappa B / Q000235:genetics / Q000378:metabolism*; D010972:Platelet Activating Factor / Q000494:pharmacology*; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology; D014162:Transfection
D016328:NF-kappa B; D010972:Platelet Activating Factor