title: [Nationally produced 153SmEDTMP in the palliative treatment of metastatic bone cancer pain].
abstract: 153SmEDTMP was obtained from enriched 152Sm irradiated at the 5 MW Chilean Research Reactor and labelled at a molar ratio of 15:1 pH 7.5. Biodistribution, autoradiography, radiochemical purity tests were done for evaluation. 40 patients were treated with 37-55 MBq/kg weight. Bone scans using 99mTcHMDP were obtained prior and after treatment. Bone marrow depression was observed in 37% of them and normal liver function in all of them. In 45% the pain dissapear completely, in 22.5% significantly decreased and partially in 30%. In 17 patients more than one dosis was injected. Our preliminary results indicate that 153SmEDTMP is a promising radiotherapeutic agent for palliative treatment of metastatic bone cancer pain and encourage its use specially because it can be produced in countries with low economic resources, thus a large number of patients can get the benefits of this new procedure.
authors.affiliation: Pontificia Universidad Católica de Chile, Santiago de Chile.
authors.forename: E
authors.initials: E
authors.lastname: Olea
authors.forename: M C
authors.initials: MC
authors.lastname: Gil
authors.forename: M
authors.initials: M
authors.lastname: Tomicic
authors.forename: G
authors.initials: G
authors.lastname: Araya
authors.forename: M
authors.initials: M
authors.lastname: Chandía
authors.forename: J C
authors.initials: JC
authors.lastname: Quintana
authors.forename: L
authors.initials: L
authors.lastname: Pinto
authors.forename: P
authors.initials: P
authors.lastname: Orellana
authors.forename: J
authors.initials: J
authors.lastname: Nagel
authors.forename: V
authors.initials: V
authors.lastname: Ortíz
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018712:Analgesics, Non-Narcotic / Q000627:therapeutic use*; D001859:Bone Neoplasms / Q000150:complications / Q000000981:diagnostic imaging / Q000556:secondary*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009942:Organometallic Compounds / Q000627:therapeutic use*; D009943:Organophosphorus Compounds / Q000627:therapeutic use*; D010148:Intractable Pain / Q000209:etiology / Q000532:radiotherapy*; D010166:Palliative Care; D011877:Radionuclide Imaging
chemical_list: D018712:Analgesics, Non-Narcotic; D009942:Organometallic Compounds; D009943:Organophosphorus Compounds; C061972:samarium Sm-153 lexidronam