Growth factors in bladder cancer.
This article is an overview of peptide growth factors, their receptors, and signal-transduction pathways that play a role in bladder cancer. Included in this overview are epidermal growth factor receptor and its ligands, erbB2, fibroblast growth factors, insulin-like growth factor, the transferrin receptor, and transforming growth factor-beta. The use of growth factors or growth factor receptors for diagnostic and therapeutic interventions is also discussed.
Liebert
M
M
Department of Urology and Cell Biology, The University of Texas, Houston 77030, USA.
D000818:Animals; D066246:ErbB Receptors / Q000378:metabolism; D005346:Fibroblast Growth Factors / Q000378:metabolism; D018734:Genes, erbB-2; D006133:Growth Substances / Q000378:metabolism*; D006801:Humans; D011990:Receptors, Transferrin / Q000378:metabolism; D013002:Somatomedins / Q000378:metabolism; D016212:Transforming Growth Factor beta / Q000378:metabolism; D001749:Urinary Bladder Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000628:therapy
D006133:Growth Substances; D011990:Receptors, Transferrin; D013002:Somatomedins; D016212:Transforming Growth Factor beta; D005346:Fibroblast Growth Factors; D066246:ErbB Receptors