Fundamental metabolic difference between cold stored lungs and livers and kidneys.
Short preservation times for lungs, are the main obstacle to exchange organs and increase the number of lung transplantations. In abdominal organ preservation UW solution has extended preservation times by including impermeable anions, adenosine and scavengers to prevent parenchymal cell swelling, to improve ATP regeneration and to inhibit reactive oxygen radicals. Metabolic changes in rabbit lungs, cold stored in UW-solution were compared with changes in rabbit livers and kidneys. Rabbit lungs swell during rewarming after a short storage period as opposed to livers and kidneys. They furthermore accumulate significantly more potassium while maintaining high ATP concentration throughout storage and reperfusion.
Schilling
M
M
Department of Visceral and Transplant Surgery, University of Bern.
Tilton
B
B
Beltzer
F O
FO
Southard
J H
JH
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D015925:Cryopreservation; D004734:Energy Metabolism / Q000502:physiology*; D016030:Kidney Transplantation / Q000502:physiology*; D016031:Liver Transplantation / Q000502:physiology*; D016040:Lung Transplantation / Q000502:physiology*; D009926:Organ Preservation; D011188:Potassium / Q000378:metabolism; D011817:Rabbits; D014022:Tissue Survival / Q000502:physiology
D000255:Adenosine Triphosphate; D011188:Potassium