Subcutaneous crystal-storing histiocytosis associated with lymphoplasmacytic lymphoma (immunocytoma)
A case of massive crystal-storing histiocytosis with extensive involvement of the subcutaneous adipose tissue in a 61-year-old caucasian woman with a lymphoplasmacytic lymphoma (immunocytoma) in transformation to a large cell lymphoma is presented. Paraffin-section immunohistochemistry demonstrated a monoclonal IgM/ kappa immunphenotype of the lymphoma cells and revealed IgM/kappa and, to a lesser extent, IgG/lambda in the crystal-containing histiocytes. Ultrastructurally, the electron dense intracytoplasmic crystals had variables shapes, were occasionally membrane-bound and measured up to 6 microns. The finding are briefly discussed.
Kaufmann
O
O
Institute of Pathology, Charité University Hospital, Berlin, Germany.
Hansen
A
A
Deicke
P
P
Burmester
G R
GR
Dietel
M
M
D003460:Crystallization; D005260:Female; D015614:Histiocytosis / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007136:Immunoglobulins / Q000378:metabolism; D007150:Immunohistochemistry; D002479:Inclusion Bodies / Q000378:metabolism; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000150:complications* / Q000473:pathology; D008854:Microscopy, Electron; D008875:Middle Aged; D012871:Skin Diseases / Q000150:complications* / Q000378:metabolism / Q000473:pathology
D007136:Immunoglobulins