Effect of SM-12502 on disseminated intravascular coagulation (DIC) in tumor-bearing rats.
To investigate the role of PAF in tumor-associated disseminated intravascular coagulation (DIC), we have established the tumor-induced DIC model in rats and examined the effect of PAF-antagonist as compared with commonly used anti-DIC drugs. Four days after the intraperitoneal inoculation of rat ascites hepatoma AH-130, DIC-like hematological parameter changes such as decrease in platelet count, prolongation of PTT and increase in FDP were observed. In addition, serum levels of GOT and GPT were increased, indicating that liver injury was provoked. PAF-antagonist SM-12502 inhibited the development of DIC (PT, PTT and FDP) and liver injury. These results indicate that PAF plays an important role in tumor-associated DIC as well as accompanying organ failure.
Morooka
S
S
Sumitomo Pharmaceuticals Research Center, Osaka, Japan.
Natsume
Y
Y
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D004211:Disseminated Intravascular Coagulation / Q000188:drug therapy* / Q000209:etiology; D007275:Injections, Intravenous; D008114:Liver Neoplasms, Experimental / Q000150:complications*; D008297:Male; D009368:Neoplasm Transplantation; D010972:Platelet Activating Factor / Q000037:antagonists & inhibitors*; D051381:Rats; D017208:Rats, Wistar; D013844:Thiazoles / Q000494:pharmacology*; D053778:Thiazolidines; D013997:Time Factors; D014407:Tumor Cells, Cultured
D010972:Platelet Activating Factor; D013844:Thiazoles; D053778:Thiazolidines; C065776:3,5-dimethyl-2-(3-pyridyl)thiazolidin-4-one; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase