title: [Prospective study of infective complications in newborns with fine silicone catheters used for parenteral nutrition infusion].
abstract: OBJECTIVE
  Percutaneous silastic central venous catheters have contributed to improve the care of neonates. They are quite safe; however, sometimes complications occur, with infections being the most frequent. A prospective study was undertaken in our NICU to know the rate of catheter-related sepsis, the influence of the duration of catheterization, the predominant portal of entry and the microorganisms isolated.
  
  
  METHODS
  Fifty-two catheters were analyzed. Cultures were obtained once a week by aspiration from the catheter hub, the luer-lock connection and parenteral nutrition solution directly from the bag. If sepsis was suspected, blood cultures were obtained from a different vein. The tip was cultured after catheter withdrawal by the semiquantitative technique of Maki.
  
  
  RESULTS
  Nineteen catheters (36.5%), 19 luer-lock connections (21.3%) and 7 parenteral nutrition solutions were colonized. We found a significant increase of the rate of colonization after the catheter had been in place 3 weeks or more (p < 0.05). Coagulase negative Staphylococcus was isolated in 75.7% of the samples. The rate of catheter related sepsis was 15.4% (7/8 caused by coagulase negative Staphylococcus).
  
  
  CONCLUSIONS
  Catheter related sepsis may be more frequent than expected it colonization of the catheter were analyzed systematically. Screening catheter colonization allows an earlier diagnosis of pathogens if sepsis develops. Finally, we believe that the use of sterile techniques to handle the catheter and connections will further decrease catheter related infections.
authors.affiliation: Departamento de Pediatría, Hospital Universitario Materno Infantil Infanta Cristina, Badajoz.
authors.forename: R
authors.initials: R
authors.lastname: Hernández Rastrollo
authors.forename: E
authors.initials: E
authors.lastname: Agulla Rodiño
authors.forename: E M
authors.initials: EM
authors.lastname: Martínez Tallo
authors.forename: J
authors.initials: J
authors.lastname: Espinosa Ruiz-Cabal
authors.forename: J
authors.initials: J
authors.lastname: Mediero Almendros
mesh_terms: D002404:Catheterization / Q000295:instrumentation*; D004866:Equipment Contamination / Q000706:statistics & numerical data*; D006801:Humans; D007231:Infant, Newborn; D007239:Infections / Q000453:epidemiology / Q000209:etiology*; D010288:Parenteral Nutrition / Q000295:instrumentation*; D011446:Prospective Studies; D012828:Silicones
chemical_list: D012828:Silicones