title: Treatment-related disseminated necrotizing leukoencephalopathy with characteristic contrast enhancement of the white matter.
abstract: This report describes unique contrast enhancement of the white matter on T1-weighted magnetic resonance images of two patients with disseminated necrotizing leukoencephalopathy, which developed from acute lymphoblastic leukemia treated with high-dose methotrexate. In both patients, the enhancement was more pronounced near the base of the brain than at the vertex. Necropsy of the first case revealed loss of myelination and necrosis of the white matter. Possible mechanisms causing such a leukoencephalopathy are discussed.
authors.affiliation: Department of Radiology, Tohoku University School of Medicine, Sendai, Japan.
authors.forename: S N
authors.initials: SN
authors.lastname: Laxmi
authors.forename: S
authors.initials: S
authors.lastname: Takahashi
authors.forename: K
authors.initials: K
authors.lastname: Matsumoto
authors.forename: S
authors.initials: S
authors.lastname: Higano
authors.forename: N
authors.initials: N
authors.lastname: Kurihara
authors.forename: M
authors.initials: M
authors.lastname: Imaizumi
authors.forename: K
authors.initials: K
authors.lastname: Abe
authors.forename: Y
authors.initials: Y
authors.lastname: Itoyama
authors.forename: K
authors.initials: K
authors.lastname: Sakamoto
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use; D001812:Blood-Brain Barrier / Q000187:drug effects / Q000528:radiation effects; D001921:Brain / Q000187:drug effects / Q000473:pathology / Q000528:radiation effects; D002540:Cerebral Cortex / Q000187:drug effects / Q000473:pathology / Q000528:radiation effects; D002648:Child; D003131:Combined Modality Therapy; D003287:Contrast Media; D016371:Cranial Irradiation; D003711:Demyelinating Diseases / Q000139:chemically induced* / Q000175:diagnosis / Q000473:pathology; D004305:Dose-Response Relationship, Drug; D004673:Encephalomyelitis, Acute Disseminated / Q000139:chemically induced* / Q000175:diagnosis / Q000473:pathology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage / Q000009:adverse effects*; D009413:Nerve Fibers, Myelinated / Q000187:drug effects / Q000473:pathology / Q000528:radiation effects; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy; D018714:Radiotherapy, Adjuvant
chemical_list: D003287:Contrast Media; D008727:Methotrexate