A mouse model of Borrelia meningitis after intradermal injection.
Both young and adult C3H/HeN mice developed meningitis within 3 weeks of intradermal inoculation with a newly identified uncultivable Borrelia species, an agent of human relapsing fever. Meningoencephalitis with perivascular infiltrates and plexitis developed at approximately 25 days after inoculation. Infiltrates were composed of B and plasma cells and monocytes. This model recreated the meningitis associated with spirochetal infections through an intradermal route of infection.
Garcia-Monco
J C
JC
Seccion de Neurologia, Hospital de Galdacano, Vizcaya, Spain.
Miller
N S
NS
Backenson
P B
PB
Anda
P
P
Benach
J L
JL
D000375:Aging; D000818:Animals; D001402:B-Lymphocytes / Q000473:pathology; D001898:Borrelia / Q000145:classification* / Q000302:isolation & purification; D001899:Borrelia Infections / Q000473:pathology / Q000503:physiopathology*; D001921:Brain / Q000473:pathology*; D006801:Humans; D016920:Meningitis, Bacterial / Q000473:pathology / Q000503:physiopathology*; D008590:Meningoencephalitis / Q000473:pathology / Q000503:physiopathology*; D051379:Mice; D008809:Mice, Inbred C3H; D009000:Monocytes / Q000473:pathology; D010950:Plasma Cells / Q000473:pathology; D012061:Relapsing Fever / Q000382:microbiology; D013997:Time Factors