Decreased in vitro fertilization efficiencies in the presence of specific cyritestin peptides.
Synthetic peptides corresponding to specific regions of the mouse acrosomal transmembrane protein cyritestin have been used as competitors in in vitro fertilization experiments. One peptide representing a putative egg-receptor binding site within the disintegrin domain of cyritestin lowered the fertilization rate to 30% of the normal value.
Linder
B
B
Institut für Genetik, Heinrich-Heine-Universität, Düsseldorf, Germany.
Heinlein
U A
UA
D051722:ADAM Proteins; D000177:Acrosome / Q000737:chemistry; D000595:Amino Acid Sequence; D000818:Animals; D005260:Female; D005307:Fertilization in Vitro / Q000187:drug effects*; D008297:Male; D008562:Membrane Glycoproteins / Q000737:chemistry / Q000494:pharmacology*; D008666:Metalloendopeptidases / Q000737:chemistry / Q000494:pharmacology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008969:Molecular Sequence Data
D008562:Membrane Glycoproteins; D051722:ADAM Proteins; C499566:ADAM3A protein, human; C485429:Adam3 protein, mouse; D008666:Metalloendopeptidases