Distribution of blood lead levels in a birth cohort of New Zealanders at age 21.
Little is known about lead exposure in the general population of young adults. In this study, whole blood lead concentration (PbB) was determined in a sample of the Dunedin Multidisciplinary Health and Development Study, a well-documented birth cohort of New Zealanders aged 21 years in 1993-1994. PbB in those who consented to venipuncture at 21 years of age (n = 779; 411 males, 368 females) was compared to PbB for the same cohort at age 11 years. The PbB at age 21 ranged from 0.4 to 56 micrograms/dl with a geometric mean of 4.5 micrograms/dl (95% CI, 4.3-4.7 micrograms/dl). Only three individuals had a PbB above 30 micrograms/dl. Males had significantly higher PbB than females (geometric mean 6.0 vs. 3.2 micrograms/dl; p < 0.0001). The PbB at age 21 was 53% lower than in the same individuals at age 11 (geometric mean 4.8 vs. 10.2 micrograms/dl; p < 0.001; n = 480) and the correlation between corresponding values was weak (r = 0.19; p < 0.001). PbB at age 21 showed significant associations with high risk occupational activities, recreational exposure, domicile close to a main road, smoking, and male sex. Blood lead concentrations continue to fall in New Zealand, but occupational and recreational activities remain a significant source of lead exposure.
Fawcett
J P
JP
School of Pharmacy, University of Otago, Dunedin, New Zealand.
Williams
S M
SM
Heydon
J L
JL
Walmsley
T A
TA
Menkes
D B
DB
D000328:Adult; D015331:Cohort Studies; D016001:Confidence Intervals; D003430:Cross-Sectional Studies; D004781:Environmental Exposure / Q000706:statistics & numerical data*; D005260:Female; D006801:Humans; D007854:Lead / Q000097:blood*; D008137:Longitudinal Studies; D008297:Male; D009520:New Zealand / Q000453:epidemiology; D012044:Regression Analysis; D012307:Risk Factors; D017678:Sex Distribution
D007854:Lead