title: Progression and prognosis of Crohn's colitis.
abstract: BACKGROUND
  Inflammation refractory to medical treatment frequently characterizes the course of Crohn's colitis, often leading to colectomy and need for a stoma. The influence of disease extent within the colon on prognosis and disease progress over time has not been studied so far.
  
  
  OBJECTIVE
  We evaluated the disease progress and the long-term outcome in 323 patients with Crohn's colitis followed-up for a mean of 9.8 years.
  
  
  METHODS
  The charts were analyzed retrospectively, the mean number of documented examinations was 18.5 per patient. The influence of disease pattern, rectal disease and perianal fistulas on the long-term outcome was evaluated using actuarial methods and independent factor analysis.
  
  
  RESULTS
  The probabilities of having pancolitis or rectal disease were 77.1% and 78.8% after 15 years, respectively, and higher in patients with initially left-sided or segmental colitis compared with right-sided colitis. The chance of having perianal fistulas was 43.3% after 15 years. The risk of undergoing resectional colonic surgery was 62.2% after 15 years and higher in the presence of right-sided colitis. The cumulative risk of colectomy was 18.2% after 15 years and higher in patients with pancolitis, left-sided colitis or in the presence of perianal fistulas. The 15-year probabilities of proctectomy (12%) and of having a temporary stoma (21%) were only influenced by the presence of perianal fistulas but not by rectal disease or pattern of colitis.
  
  
  CONCLUSIONS
  Most patients with colonic Crohn's disease will eventually have pancolitis but only 20% of them will loose the colon. The proctectomy rate is low despite a high frequency of rectal disease. Perianal fistulas and the presence of total or left-sided colonic involvement are adverse risk factors with regard to preservation of colonic length.
authors.affiliation: Department of Surgery, University of Tübingen.
authors.forename: F
authors.initials: F
authors.lastname: Makowiec
authors.forename: C
authors.initials: C
authors.lastname: Schmidtke
authors.forename: D
authors.initials: D
authors.lastname: Paczulla
authors.forename: R
authors.initials: R
authors.lastname: Lamberts
authors.forename: H D
authors.initials: HD
authors.lastname: Becker
authors.forename: M
authors.initials: M
authors.lastname: Starlinger
mesh_terms: D000328:Adult; D003082:Colectomy; D003106:Colon / Q000473:pathology; D003125:Colostomy; D003424:Crohn Disease / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007081:Ileostomy; D007082:Ileum / Q000473:pathology; D008297:Male; D012003:Rectal Fistula / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D012007:Rectum / Q000473:pathology; D016896:Treatment Outcome