BCG specificity of an inhibitory seric factor from tuberculosis anergic patients that acts on non-adherent PPD reactive cells.
The effect of tuberculosis anergic immune sera adsorbed with BCG was studied on cocultures of adherent and non-adherent cells from PPD+ tuberculosis patient (TBP PPD+). This effect on the cocultures was quantified by lymphocyte transformation (LT) test using PPD as antigen. Only those cocultures with non-adherent cells from TBP PPD+ patients treated with anergic sera, inhibited the LT response induced by PPD, whereas sera adsorption with BCG eliminated the inhibitory effect.
Mejía-López
H
H
Departamento de Microbiología-Parasitología, Facultad de Medicina UNAM, México, D. F., México.
Martínez-García
L G
LG
Zenteno
E
E
Salazar
M A
MA
Selman
M
M
Taylor
M L
ML
D000327:Adsorption; D000907:Antibodies, Bacterial / Q000276:immunology; D001500:BCG Vaccine / Q000276:immunology* / Q000494:pharmacology*; D002448:Cell Adhesion / Q000502:physiology; D002478:Cells, Cultured; D006801:Humans; D008213:Lymphocyte Activation; D009169:Mycobacterium tuberculosis / Q000276:immunology; D012680:Sensitivity and Specificity; D014374:Tuberculin Test; D014397:Tuberculosis, Pulmonary / Q000097:blood* / Q000276:immunology*
D000907:Antibodies, Bacterial; D001500:BCG Vaccine