Retinoid signalling and axial patterning during early vertebrate embryogenesis.
There are many indications that active retinoids are regulatory signals during vertebrate embryogenesis. Treating vertebrate embryos with retinoids can cause teratogenic defects, including specific derangements of the main body axis. Other data show that early vertebrate embryos contain physiologically relevant concentrations of active retinoids and express retinoid binding proteins and receptors; that knockouts of retinoid receptors can induce homeotic defects; and that relevant developmental control genes are regulated by retinoid response elements. Here, we discuss the possibility that retinoids are developmental signals which regulate axial patterning in the early vertebrate embryo.
Durston
A J
AJ
Hubrecht Laboratory, Netherlands Institute for Developmental Biology, Utrecht The Netherlands.
van der Wees
J
J
Pijnappel
W W
WW
Schilthuis
J G
JG
Godsave
S F
SF
D000818:Animals; D019521:Body Patterning / Q000187:drug effects; D018398:Homeodomain Proteins / Q000502:physiology; D018168:Receptors, Retinoic Acid / Q000502:physiology; D012176:Retinoids / Q000378:metabolism* / Q000494:pharmacology; D013723:Teratogens / Q000494:pharmacology; D014714:Vertebrates / Q000196:embryology; D014982:Xenopus laevis / Q000196:embryology*
D018398:Homeodomain Proteins; D018168:Receptors, Retinoic Acid; D012176:Retinoids; D013723:Teratogens