Murine hepatic p53, RB, and CDK inhibitory protein expression following acute 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure.
This study examined the expression of murine hepatic tumor suppressor and cell cycle inhibitory proteins in response to acute 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) dosing in Balb/c mice. Elevations in expression of p53, retinoblastoma (Rb) protein, p16Ink4, p21Waf1 and p27Kip1 were observed six days after a single dose of 0.25, 0.5, 1 or 2 micrograms TCDD/kg. These data suggest that the TCDD-induced inhibition of hepatocyte proliferation in vivo could be attributed to the expression of cell cycle inhibitory proteins.
Rininger
J A
JA
Paracelsian Inc. Langmuir Laboratories, Ithaca, NY 14850, USA.
Stoffregen
D A
DA
Babish
J G
JG
D000818:Animals; D002352:Carrier Proteins / Q000096:biosynthesis; D002453:Cell Cycle / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D019941:Cyclin-Dependent Kinase Inhibitor p16; D018844:Cyclin-Dependent Kinases / Q000037:antagonists & inhibitors*; D004791:Enzyme Inhibitors / Q000378:metabolism*; D005260:Female; D016147:Genes, Tumor Suppressor; D016158:Genes, p53; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D000072317:Polychlorinated Dibenzodioxins / Q000633:toxicity*; D016160:Retinoblastoma Protein / Q000096:biosynthesis*
D002352:Carrier Proteins; D019941:Cyclin-Dependent Kinase Inhibitor p16; D004791:Enzyme Inhibitors; D000072317:Polychlorinated Dibenzodioxins; D016160:Retinoblastoma Protein; D018844:Cyclin-Dependent Kinases