Cholelithiasis in cirrhotic patients. (Analysis of cholelithiasis among patients with liver cirrhosis in São Paulo, Brazil).
During the past 20 years, several authors have reported increased prevalence of cholelithiasis in liver cirrhosis. This biliary disease has been implicated with the deterioration of liver function, liver disease of alcoholic origin or even the presence of hypersplenism in this patient population. This study analyzes the incidence and possible factors which are responsible for promoting cholelithiasis in cirrhosis. The study included 110 cirrhotic patients of a private center specialized in treating liver diseases. The incidence of cholelithiasis was 27.3% (25.3% in males and 33.3% in females). There was no correlation between liver function defined by Child's classification or through the laboratory examinations (AST, ALT, AP, GGT, PT, Alb, TB, DB, PA) and the presence of gallstones. No evidence was found that the etiology of cirrhosis or the presence/absence of hypersplenism affected the prevalence of cholelithiasis in this population. In conclusion, an increased prevalence of cholelithiasis was verified in this population of cirrhotics but the pathogenesis is still obscure.
Genzini
T
T
Centro Terapêutico Especializado em Fígado (Liver Therapy Center)-CETEFI Hospital Beneficência Portuguesa de São Paulo, Brazil.
de Miranda
M P
MP
de Oliveira e Silva
A
A
de Souza
C P
CP
Silva
F A
FA
de Melo
C R
CR
dos Santos
T E
TE
Cardoso
E S
ES
Santo
G C
GC
Lee
M P
MP
D'Albuquerque
L A
LA
D000293:Adolescent; D000328:Adult; D000368:Aged; D001938:Brazil / Q000453:epidemiology; D016009:Chi-Square Distribution; D002648:Child; D002675:Child, Preschool; D002769:Cholelithiasis / Q000150:complications* / Q000453:epidemiology / Q000601:surgery; D003627:Data Interpretation, Statistical; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D008103:Liver Cirrhosis / Q000150:complications*; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012307:Risk Factors