title: Systemic reactions in U.S. Marine Corps personnel who received Japanese encephalitis vaccine.
abstract: The overall hypersensitivity reaction rate among 14,249 U.S. Marine Corps personnel who received 36,850 doses of an investigational Japanese encephalitis vaccine was 10.3 per 10,000 doses; reaction rates were 16.1 and 10.3 per 10,000 doses for the first two doses, and 2.0 per 10,000 doses for the third. The reaction rate was 26.7 per 10,000 vaccinees. Of 38 reactors, 26 had urticaria and/or angioedema, and 11 had pruritus. Vaccine reaction intervals clustered within 48 hours for dose 1, but the median reaction interval for dose 2 was 96 hours. A history of urticaria or allergic rhinitis was associated with an increased probability of a vaccine reaction.
authors.affiliation: Navy Environmental Health Center, Norfolk, Virginia, USA.
authors.forename: S W
authors.initials: SW
authors.lastname: Berg
authors.forename: B S
authors.initials: BS
authors.lastname: Mitchell
authors.forename: R K
authors.initials: RK
authors.lastname: Hanson
authors.forename: R P
authors.initials: RP
authors.lastname: Olafson
authors.forename: R P
authors.initials: RP
authors.lastname: Williams
authors.forename: J E
authors.initials: JE
authors.lastname: Tueller
authors.forename: R J
authors.initials: RJ
authors.lastname: Burton
authors.forename: D M
authors.initials: DM
authors.lastname: Novak
authors.forename: T F
authors.initials: TF
authors.lastname: Tsai
authors.forename: F S
authors.initials: FS
authors.lastname: Wignall
mesh_terms: D004664:Encephalitis Virus, Japanese / Q000276:immunology*; D006801:Humans; D007114:Immunization; D008889:Military Personnel; D014765:Viral Vaccines / Q000009:adverse effects*
chemical_list: D014765:Viral Vaccines