Histological and ultrastructural study of one case of oral bacillary angiomatosis in HIV disease and review of the literature.
Bacillary angiomatosis (BA) is a new clinicopathological entity defined as a pseudo-neoplastic capillary proliferation secondary to an opportunistic infection by one of two Rochalimaea sp.: R. quintana or R. henselae. Although BA is a recently recognised entity, numerous cases have been reported. Most of the patients affected are reported to have low absolute CD4 lymphocyte counts associated with AIDS. Yet, very few oral cases associated or not with cutaneous lesions have been reported or simply identified. Histopathological and ultrastructural features of one case of oral BA with gingival and palatal lesions are presented. Clinical aspects of oral BA do not hold pathognomonic features and the lesions may resemble either a reactive lesion of the gingiva, pyogenic granuloma or Kaposi's sarcoma. The lesion is characteristically composed of circumscribed lobular capillary proliferations and the presence of granular amphophilic material on haematoxylin and eosin sections surrounded by neutrophils and neutrophilic debris is a clue to diagnosis. Demonstration of bacilli in the interstitium by the Warthin-Starry silver method or, better, by electron microscopy is diagnostic. BA may contribute to the death of the patient but erythromycin has proved to be very effective treatment.
Monteil
R A
RA
Oral Pathobiology Laboratory, Faculty of Dental Surgery, University of Nice, France.
Michiels
J F
JF
Hofman
P
P
Saint-Paul
M C
MC
Hitzig
C
C
Perrin
C
C
Santini
J
J
D017088:AIDS-Related Opportunistic Infections / Q000473:pathology*; D000328:Adult; D016917:Angiomatosis, Bacillary / Q000209:etiology* / Q000473:pathology; D001473:Bartonella / Q000302:isolation & purification* / Q000648:ultrastructure; D001706:Biopsy; D005881:Gingiva / Q000473:pathology; D006679:HIV Seropositivity / Q000150:complications / Q000382:microbiology*; D015497:HIV-1; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D009059:Mouth Diseases / Q000382:microbiology* / Q000473:pathology; D009061:Mouth Mucosa / Q000382:microbiology / Q000473:pathology* / Q000648:ultrastructure; D010159:Palate / Q000473:pathology