Massive gastric hemorrhage induced by buffered aspirin in a greyhound.
A 13-year-old, neutered male greyhound was presented with severe hematemesis and hematochezia following only three doses of buffered aspirin that were within therapeutic recommendations. Transfusion of seven units of whole blood was required to stabilize the patient. Diagnostic evaluation failed to reveal an underlying disease state that could have predisposed the dog to massive gastric hemorrhage. This is the first report of buffered aspirin causing clinically significant disease during routine administration.
Shaw
N
N
Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville 32610-0126, USA.
Burrows
C F
CF
King
R R
RR
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D001241:Aspirin / Q000009:adverse effects*; D001808:Blood Vessels / Q000187:drug effects / Q000473:pathology; D004283:Dog Diseases / Q000139:chemically induced* / Q000473:pathology; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D005753:Gastric Mucosa / Q000737:chemistry / Q000378:metabolism / Q000473:pathology; D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced / Q000473:pathology / Q000662:veterinary*; D006632:Histamine / Q000032:analysis / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D008297:Male; D011453:Prostaglandins / Q000032:analysis / Q000378:metabolism; D013272:Stomach Diseases / Q000139:chemically induced / Q000473:pathology / Q000662:veterinary*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D011453:Prostaglandins; D006632:Histamine; D001241:Aspirin