title: Recombinant and nonrecombinant factor XIII and its effect on bone ingrowth and strength of fixation.
abstract: Thirty cylindrical, commercially pure, titanium fiber, porous-coated Ti6Al4V implants were inserted press-fit into the proximal humeral portion of 30 sheep humeri to determine the systemic effect of recombinant factor XIII and placenta-derived factor XIII concentrate on bone ingrowth and strength of fixation. For both the recombinant factor XIII and the factor XIII concentrate group, the volume of bone ingrowth and the strength of fixation were higher than for the control specimens. However, the difference was only significant for the factor XIII concentrate group.
authors.affiliation: Zentrum Operative Medizin II, Philipps Universität, Marburg, Germany.
authors.forename: H
authors.initials: H
authors.lastname: Kienapfel
authors.forename: R
authors.initials: R
authors.lastname: Swain
authors.forename: A
authors.initials: A
authors.lastname: Hettel
authors.forename: A
authors.initials: A
authors.lastname: Wilke
authors.forename: M
authors.initials: M
authors.lastname: Koller
authors.forename: P
authors.initials: P
authors.lastname: Griss
mesh_terms: D000818:Animals; D015478:Antigens, Heterophile / Q000032:analysis; D001696:Biomechanical Phenomena; D016723:Bone Remodeling / Q000187:drug effects; D004195:Disease Models, Animal; D004797:Enzyme-Linked Immunosorbent Assay; D005176:Factor XIII / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D015999:Multivariate Analysis; D016348:Osseointegration / Q000187:drug effects*; D016062:Porosity; D019736:Prostheses and Implants; D011994:Recombinant Proteins / Q000627:therapeutic use; D012756:Sheep; D014025:Titanium / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D015478:Antigens, Heterophile; D011994:Recombinant Proteins; D005176:Factor XIII; D014025:Titanium