Molecular mechanisms of defective eosinophil apoptosis in diseases associated with eosinophilia.
Apoptosis is a necessary process to maintain correct cell numbers in a multicellular organism. Defects in this process may contribute to the pathogenesis of a number of human diseases. We have suggested that inhibition of apoptosis in eosinophils by cytokines such as IL-5 and GM-CSF may play an important role in the pathogenesis of allergic disorders. Here, we review our recent progress in understanding the processes regulating eosinophil apoptosis.
Simon
H U
HU
Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos. hus@SIAF.unizh.ch
D017209:Apoptosis; D004802:Eosinophilia / Q000503:physiopathology*; D004804:Eosinophils / Q000502:physiology*; D006801:Humans; D015848:Interleukin-5 / Q000502:physiology; D016187:Receptors, Granulocyte-Macrophage Colony-Stimulating Factor / Q000502:physiology; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000502:physiology
D015848:Interleukin-5; D016187:Receptors, Granulocyte-Macrophage Colony-Stimulating Factor