title: Prevalence of hepatitis E in a central Italian town at high endemicity for hepatitis C virus.
abstract: In the spring of 1994, the occurrence of Hepatitis E virus antibodies was evaluated in 653 subjects representing all age-groups in the general population of a Central Italian town, where a high hepatitis C virus prevalence had been reported. The overall anti-HEV prevalence was 2.6% ranging from 1.4% in the 30-49 age-group to 5.7% (p < 0.01) in the 60-70 age-group; none of the subjects under 30 years of age were positive. Sociodemographic variables, such as family size and years of schooling were not associated with HEV exposure. Anti-HEV positivity was found in 1.8% (1/56) of the subjects who were positive for anti-HCV and in 2.7% (16/597) of those who were anti-HCV negative (O.R 1.5; C.I.: 95% = 0.2-11.7). Thus no association was found between HEV and HCV infections. These data suggest a past spread of HEV in this area and underline the occurrence of long-lasting antibodies in infected subjects.
authors.affiliation: Divisìone di Medicina, Ospedale di Montefiascone, I.S.S., Roma, Italy.
authors.forename: T
authors.initials: T
authors.lastname: Stroffolini
authors.forename: M
authors.initials: M
authors.lastname: Menchinelli
authors.forename: V
authors.initials: V
authors.lastname: Dambruoso
authors.forename: F
authors.initials: F
authors.lastname: Menniti Ippolito
authors.forename: A
authors.initials: A
authors.lastname: Costantino
authors.forename: M
authors.initials: M
authors.lastname: Rapicetta
authors.forename: R
authors.initials: R
authors.lastname: Lecce
authors.forename: G
authors.initials: G
authors.lastname: Taliani
mesh_terms: D000328:Adult; D000368:Aged; D019353:Endemic Diseases; D005260:Female; D016174:Hepacivirus / Q000276:immunology*; D006508:Hepatitis Antibodies / Q000032:analysis; D006526:Hepatitis C / Q000453:epidemiology / Q000821:virology; D018937:Hepatitis C Antibodies / Q000032:analysis*; D016751:Hepatitis E / Q000453:epidemiology* / Q000821:virology; D016752:Hepatitis E virus / Q000276:immunology*; D006801:Humans; D007124:Immunoenzyme Techniques; D007074:Immunoglobulin G / Q000276:immunology; D007558:Italy / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012189:Retrospective Studies; D011795:Surveys and Questionnaires; D014505:Urban Population
chemical_list: D006508:Hepatitis Antibodies; D018937:Hepatitis C Antibodies; D007074:Immunoglobulin G