13beta,14beta-dihydroxy-13alpha-isopropylabietic acid, an elicitor of contact allergy.
Abietic acid isolated from colophony (W.W. grade) was selectively oxidized in the presence of KMnO4, into 13beta,14beta-dihydroxy-14alpha-isopropylabietic acid. The structure of the compound was elucidated using UV, IR, and NMR spectroscopy. Epicutaneous application of the dihydroxy acid to colophony-sensitized guinea pigs suggested the compound as an elicitor of contact allergy that had not been tested before in contact-sensitization reactions.
Khan
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Natural Drugs Division, PCSIR Laboratories, Peshawar, Pakistan.
Saeed
M A
MA
D045784:Abietanes; D000818:Animals; D003877:Dermatitis, Contact / Q000209:etiology*; D004224:Diterpenes / Q000378:metabolism / Q000633:toxicity*; D006168:Guinea Pigs; D010084:Oxidation-Reduction; D010616:Phenanthrenes / Q000378:metabolism / Q000633:toxicity*
D045784:Abietanes; D004224:Diterpenes; D010616:Phenanthrenes; C023710:abietic acid