Analysis of the tyrosine hydroxylase and dopamine D4 receptor genes in a Croatian sample of bipolar I and unipolar patients.
We selected 83 patients with bipolar disorder type I or unipolar recurrent major depression and 71 healthy controls for genetic analysis of the tyrosine hydroxylase and the dopamine D4 receptor gene. No significant association was found between bipolar disorder type I and unipolar recurrent major depression and the polymorphisms located near these genes. Therefore, the hypothesis that the tyrosine hydroxylase and the dopamine D4 receptor genes may be involved in the etiology of bipolar disorder and unipolar recurrent major depression is not supported in our study.
Oruc
L
L
Neurogenetics Laboratory, Flanders Interuniversity Institute for Biotechnology, University of Antwerp, Belgium.
Verheyen
G R
GR
Furac
I
I
Jakovljević
M
M
Ivezić
S
S
Raeymaekers
P
P
Van Broeckhoven
C
C
D000328:Adult; D000368:Aged; D001714:Bipolar Disorder / Q000201:enzymology / Q000235:genetics*; D017523:Croatia; D003866:Depressive Disorder / Q000201:enzymology / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D017448:Receptors, Dopamine D2 / Q000235:genetics*; D050638:Receptors, Dopamine D4; D014446:Tyrosine 3-Monooxygenase / Q000235:genetics*
C493599:DRD4 protein, human; D017448:Receptors, Dopamine D2; D050638:Receptors, Dopamine D4; D014446:Tyrosine 3-Monooxygenase