Bidirectional blockade of CD4 and MHC class II molecules is an effective immunosuppressive treatment.
Ito
H
H
First Department of Surgery, Yamaguchi University School of Medicine, Japan.
Hamano
K
K
Shirasawa
B
B
Tsuboi
H
H
Esato
K
K
Wood
K J
KJ
D000818:Animals; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D015704:CD4 Antigens / Q000276:immunology*; D016207:Cytokines / Q000096:biosynthesis*; D006085:Graft Survival; D016027:Heart Transplantation / Q000276:immunology*; D000949:Histocompatibility Antigens Class II / Q000276:immunology*; D007165:Immunosuppression Therapy / Q000379:methods; D000922:Immunotoxins / Q000627:therapeutic use*; D007371:Interferon-gamma / Q000096:biosynthesis; D015847:Interleukin-4 / Q000096:biosynthesis; D007959:Lymphocyte Culture Test, Mixed; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL
D000911:Antibodies, Monoclonal; D015704:CD4 Antigens; D016207:Cytokines; D000949:Histocompatibility Antigens Class II; D000922:Immunotoxins; D015847:Interleukin-4; D007371:Interferon-gamma