[Trends and perspectives in environmental oncology].
Environmental oncology is a discipline concerned with studies of multi-aspect relationships between environment and living organisms exposed to the modifying influence of carcinogenic agents. It also deals with general biological regularities involved in neoplasm development as well as their prevention in different species including man, animals and plants. Various investigations conducted at the Laboratory and supported with Russian and foreign grants (1991-1996) are briefly discussed. Among them are biotesting environmental carcinogens (aminoanthraquinons, by-products of drinking water chlorination, development of new testing systems and objects of detection involved in identification of genotoxic substances (criteria for formation of short-term test batteries and evaluation of perspectives, methods and results), investigation of xenobiotic metabolic activation (enzyme imprinting in adult animals), search for anticarcinogens (classification of carcinogenesis inhibitors, development of testing systems for modifiers selection), and establishing environment-related regularities of tumor growth. Vistas in environmental oncology development are discussed.
Khudoleĭ
V V
VV
Mizgirev
I V
IV
D000818:Animals; D002273:Carcinogens / Q000009:adverse effects*; D004787:Environmental Pollution; D006801:Humans; D009369:Neoplasms / Q000191:economics / Q000209:etiology* / Q000517:prevention & control*; D012109:Research Support as Topic; D012426:Russia
D002273:Carcinogens