title: Regulation of rat neuronal nitric oxide synthase activity by chronic alcoholization.
abstract: Rat neuronal nitric oxide (NO) synthase (nNOS) activity was measured in frontal cortex, hippocampus, striatum and cerebellum using the assay of [3H]citrulline, following chronic alcoholization. The Km and Vmax values were significantly increased in the frontal cortex and in the striatum, and were not affected in the cerebellum and hippocampus.
authors.affiliation: INSERM U295, Université de Médecine Pharmacie, Saint Etienne du Rouvray, France.
authors.forename: M
authors.initials: M
authors.lastname: Naassila
authors.forename: F
authors.initials: F
authors.lastname: Beauge
authors.forename: M
authors.initials: M
authors.lastname: Daoust
mesh_terms: D000437:Alcoholism / Q000201:enzymology*; D000818:Animals; D001921:Brain / Q000201:enzymology*; D001931:Brain Mapping; D003342:Corpus Striatum / Q000201:enzymology; D004790:Enzyme Induction / Q000187:drug effects; D000431:Ethanol / Q000633:toxicity; D005625:Frontal Lobe / Q000201:enzymology; D008297:Male; D009474:Neurons / Q000201:enzymology; D019001:Nitric Oxide Synthase / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000431:Ethanol; D019001:Nitric Oxide Synthase