A peptide from the submandibular glands modulates inflammatory responses.
BACKGROUND
The cervical sympathetic trunk-submandibular gland (CST-SMG) axis plays an important role in inflammation. An immunoregulatory heptapeptide, submandibular gland peptide T (SGP-T), was isolated from submandibular glands, and several of its biological activities have been identified.


RESULTS
SGP-T reduced shock-induced hypotension and allergen-induced disruption of migrating myoelectric complexes and the magnitude of smooth muscle contraction. The heptapeptide inhibited the influx of neutrophils into carrageenin-soaked sponges.


CONCLUSIONS
SGP-T has several biological activities that collectively help explain the ability of the CST-SMG axis to regulate inflammation.
Mathison
R D
RD
Department of Physiology and Biophysics, Faculty of Medicine, University of Calgary, Canada.
Davison
J S
JS
Befus
A D
AD
D000707:Anaphylaxis / Q000517:prevention & control; D000818:Animals; D002634:Chemotaxis, Leukocyte / Q000187:drug effects; D007249:Inflammation / Q000276:immunology*; D009504:Neutrophils / Q000276:immunology; D009842:Oligopeptides / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013363:Submandibular Gland / Q000737:chemistry*
D009842:Oligopeptides