title: Protection against noise trauma by sound conditioning.
abstract: Sound conditioning provides protection against a subsequent noise trauma. The sound conditioning paradigm consists of a low-level, long-term, non-damaging acoustic stimulus (1 kHz, 81 dB SPL x 24 days). Morphological and physiological alterations are not induced by the sound conditioning stimulus alone. In addition, the middle ear muscles have been shown not to be influenced by sound conditioning. It has been shown that after exposure to a traumatic stimulus, sound conditioning protects the outer hair cell morphology (fewer missing outer hair cells), as well as physiology (distortion product otoacoustic emissions) compared to an unconditioned group exposed only to the traumatic stimulus. Further studies are needed in order to establish the underlying mechanisms for the phenomenon of sound conditioning. Nevertheless, since sound-conditioning experiments have been successfully applied to human subjects our understanding of hearing impaired individuals has been enhanced.
authors.affiliation: Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
authors.forename: B
authors.initials: B
authors.lastname: Canlon
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D003051:Cochlea / Q000503:physiopathology; D004432:Ear, Middle / Q000503:physiopathology; D006168:Guinea Pigs; D018072:Hair Cells, Auditory, Outer / Q000473:pathology / Q000503:physiopathology; D006317:Hearing Loss, Noise-Induced / Q000503:physiopathology* / Q000517:prevention & control* / Q000534:rehabilitation; D006801:Humans; D013016:Sound / Q000009:adverse effects