title: Testing electromagnetic fields for potential carcinogenic activity: a critical review of animal models.
abstract: In order to assess the potential of electromagnetic fields (EMF) to influence the process of carcinogenesis, it will be necessary to supplement epidemiological studies with controlled laboratory studies in animals. There are now a number of suitable assays available that focus on different histopathological forms of cancer and on different stages of carcinogenesis--induction, promotion, progression. In this review we discuss eight major systems in the context of this generalized carcinogenesis paradigm. Our aim is to bring together what is currently known about the biology of carcinogenesis in these systems in order to provide a context for evaluating EMF results as they become available. We also critically discuss EMF test results that have so far been obtained in the animal models reviewed. Most of the 19 completed studies identified were negative. However, suggestive positive results were reported in three promotion assays (in rat mammary gland, in rat liver, and in mouse skin), and in one multigeneration study in mice. Results in the rat liver assay and in the multigeneration study have only been reported in abstract form and cannot be adequately evaluated. Positive results reported in both the rat mammary gland and the mouse skin systems are of weak statistical significance and have not been independently replicated. However, it may be of interest that effects in both systems appear primarily to involve the progression stage of carcinogenesis. We suggest that more definitive conclusions as to the carcinogenic potential of EMF may require expanded test protocols that reinforce traditional carcinogenesis end points with biochemical or other parameters reflective of biological processes known to be associated with carcinogenesis in the different systems.
authors.affiliation: Electric Power Research Institute, Palo Alto, California 94303, USA. 102733.2717@compuserve.com
authors.forename: J
authors.initials: J
authors.lastname: McCann
authors.forename: R
authors.initials: R
authors.lastname: Kavet
authors.forename: C N
authors.initials: CN
authors.lastname: Rafferty
mesh_terms: D000818:Animals; D003043:Cocarcinogenesis; D004195:Disease Models, Animal; D004574:Electromagnetic Fields / Q000009:adverse effects*; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D007942:Leukemia, Experimental / Q000209:etiology; D008297:Male; D051379:Mice; D008822:Mice, Transgenic; D009369:Neoplasms / Q000209:etiology; D009374:Neoplasms, Experimental / Q000209:etiology*; D051381:Rats