CT demonstration of periorbital graft-versus-host disease.
A 13-year-old boy who had undergone allogenic bone marrow transplantation for treatment of acute lymphocytic leukemia presented with bilateral periorbital rash and swelling. A CT scan showed bilateral symmetric periorbital swelling, subconjunctival fluid collections, and lacrimal gland enlargement. The patient was initially treated for presumed cellulitis. However, persistently negative regional cultures (eye, nasopharynx), a rapid response to immunosuppressive therapy after several days of nonresponse to intravenous antibiotic therapy, and ultimately, results of a skin biopsy confirmed the diagnosis of acute graft-versus-host disease.
Cole
J W
JW
Department of Radiology, University of Michigan Hospitals, Ann Arbor 48109, USA.
Quint
D J
DJ
Hutchinson
R J
RJ
Yanik
G A
GA
D000208:Acute Disease; D000293:Adolescent; D000900:Anti-Bacterial Agents; D001706:Biopsy; D016026:Bone Marrow Transplantation / Q000009:adverse effects; D002481:Cellulitis / Q000188:drug therapy / Q000473:pathology; D004359:Drug Therapy, Combination / Q000008:administration & dosage / Q000627:therapeutic use; D004487:Edema / Q000473:pathology; D005122:Exudates and Transudates; D006086:Graft vs Host Disease / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007275:Injections, Intravenous; D007766:Lacrimal Apparatus Diseases / Q000473:pathology; D008297:Male; D009916:Orbital Diseases / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000473:pathology; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000628:therapy; D012867:Skin / Q000473:pathology; D014057:Tomography, X-Ray Computed; D014184:Transplantation, Homologous; D014581:Urticaria / Q000473:pathology
D000900:Anti-Bacterial Agents; D007166:Immunosuppressive Agents