title: Prognostic value of cardiac troponin T after noncardiac surgery: 6-month follow-up data.
abstract: OBJECTIVE
  We sought to evaluate the prognostic significance of cardiac troponin T (TnT) serum levels after noncardiac surgery.
  
  
  BACKGROUND
  Cardiac TnT has been found to be marker for myocardial injury, but elevations of TnT are common in patients undergoing noncardiac surgery without clinical evidence of severe ischemia.
  
  
  METHODS
  We studied 772 patients who underwent major noncardiac procedures and did not have major cardiovascular complications during their inpatient course. Total serum creatine kinase (CK) and cardiac TnT were measured according to a protocol that included sampling in the recovery room and during the next 2 days. A 6-month follow-up interview was performed for 722 (94%) of the patients.
  
  
  RESULTS
  Elevated cardiac TnT and CK-MB results were detected for 92 (12%) and 211 (27%) patients, respectively. During the follow-up period, there were 19 (2.5%) major cardiac complications, including 14 cardiac deaths, 3 nonfatal myocardial infarctions and 2 admissions for unstable angina. Compared with patients with cardiac TnT values < 0.1 ng/ml, patients with elevated TnT had a relative risk for cardiac events of 5.4 (95% confidence interval: 2.2 to 13, p = 0.001), whereas CK-MB was not correlated with postdischarge cardiac events. In multivariate logistic regression analysis adjusting for preoperative clinical and CK-MB data, a cardiac TnT value > 0.1 ng/ml was in independent correlate of cardiac events (adjusted odds ratio 4.6, p < 0.05). This correlation was a function of the relation of elevated TnT levels with postoperative in-hospital congestive heart failure and new sustained arrhythmias, suggesting that elevated postoperative TnT levels detected myocardial ischemia during these clinical events.
  
  
  CONCLUSIONS
  We conclude that an abnormal TnT level in patients undergoing noncardiac surgery may be a useful marker of ischemic disease and a predictor of 6-month prognosis.
authors.affiliation: Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
authors.forename: F
authors.initials: F
authors.lastname: Lopez-Jimenez
authors.forename: L
authors.initials: L
authors.lastname: Goldman
authors.forename: D B
authors.initials: DB
authors.lastname: Sacks
authors.forename: E J
authors.initials: EJ
authors.lastname: Thomas
authors.forename: P A
authors.initials: PA
authors.lastname: Johnson
authors.forename: E F
authors.initials: EF
authors.lastname: Cook
authors.forename: T H
authors.initials: TH
authors.lastname: Lee
mesh_terms: D001145:Arrhythmias, Cardiac / Q000097:blood* / Q000175:diagnosis; D015415:Biomarkers / Q000097:blood*; D015331:Cohort Studies; D003402:Creatine Kinase / Q000097:blood; D005260:Female; D005500:Follow-Up Studies; D006333:Heart Failure / Q000097:blood* / Q000175:diagnosis; D006801:Humans; D007527:Isoenzymes; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000175:diagnosis; D011183:Postoperative Complications / Q000097:blood* / Q000175:diagnosis; D011237:Predictive Value of Tests; D011379:Prognosis; D012680:Sensitivity and Specificity; D013514:Surgical Procedures, Operative; D013997:Time Factors; D014336:Troponin / Q000097:blood*; D020107:Troponin T
chemical_list: D015415:Biomarkers; D007527:Isoenzymes; D014336:Troponin; D020107:Troponin T; D003402:Creatine Kinase