title: Liposome encapsulated doxorubicin transfer to the pelvic lymph nodes by endoscopic administration into the bladder wall: a preliminary report.
abstract: OBJECTIVE
  Liposome encapsulated doxorubicin administered to the pelvic lymph nodes might be effective against pelvic node metastasis. We determined whether the drug can be delivered to the nodes via the bladder wall.
  
  
  METHODS
  Ten patients underwent endoscopic administration of 10 mg. liposomal doxorubicin into the bladder wall 3 days before cystectomy. The concentration of doxorubicin in the pelvic lymph nodes obtained at operation was measured.
  
  
  RESULTS
  No complication developed after drug administration. Almost all lymph nodes examined contained more than 100 ng./gm. doxorubicin (median 1,860).
  
  
  CONCLUSIONS
  Endoscopic administration of liposomal doxorubicin into the bladder wall may be an alternative method to deliver doxorubicin to the pelvic lymph nodes.
authors.affiliation: Department of Urology, Shinshu University School of Medicine, Matsumoto, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Tsuruta
authors.forename: O
authors.initials: O
authors.lastname: Muraishi
authors.forename: Y
authors.initials: Y
authors.lastname: Katsuyama
authors.forename: Y
authors.initials: Y
authors.lastname: Murata
authors.forename: M
authors.initials: M
authors.lastname: Ichino
authors.forename: A
authors.initials: A
authors.lastname: Ogawa
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D004317:Doxorubicin / Q000008:administration & dosage*; D004337:Drug Carriers; D005260:Female; D006801:Humans; D007267:Injections; D008081:Liposomes; D008198:Lymph Nodes; D008297:Male; D008875:Middle Aged; D010388:Pelvis; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy*
chemical_list: D004337:Drug Carriers; D008081:Liposomes; D004317:Doxorubicin