[Lipoprotein receptors. Old acquaintances and newcomers].
Lipoprotein receptors are plasma membrane proteins of high affinity which interact with circulating lipoprotein particles. The well characterized LDL receptor continues to be analysed and some new findings on its intracellular mechanisms of action have emerged. New lipoprotein receptors have recently been described: the chylomicron remnant receptor or LDL-related protein (LRP), the lipolysis stimulated receptor (LSR), the very low density lipoprotein receptor (VLDLR), the HDL receptor (HDLR) and the scavenger receptor (SR). The molecular details of the receptors will facilitate the development of new therapeutic means to improve receptor-mediated clearance of lipoproteins.
Ducobu
J
J
Service de Médecine Interne, Centre Hospitalier Universitaire de Tivoli, La Louvière.
D002914:Chylomicrons / Q000502:physiology; D006801:Humans; D008079:Lipoproteins, VLDL / Q000502:physiology; D008565:Membrane Proteins; D009154:Mutation; D011971:Receptors, Immunologic / Q000502:physiology; D011973:Receptors, LDL / Q000502:physiology; D018110:Receptors, Lipoprotein / Q000235:genetics / Q000502:physiology*; D051116:Receptors, Scavenger; D051122:Scavenger Receptors, Class B; D013329:Structure-Activity Relationship
D002914:Chylomicrons; D008079:Lipoproteins, VLDL; D008565:Membrane Proteins; D011971:Receptors, Immunologic; D011973:Receptors, LDL; D018110:Receptors, Lipoprotein; D051116:Receptors, Scavenger; C454739:Scarb1 protein, mouse; D051122:Scavenger Receptors, Class B; C036053:VLDL receptor; C028203:chylomicron receptor; C085992:lipolysis-stimulated receptor