Cyclins, cyclin-dependent kinases and differentiation.
Cyclin-dependent kinases and their regulatory subunits, the cyclins, are known to regulate progression through the cell cycle. Yet these same proteins are often expressed in non-cycling, differentiated cells. This review surveys the available information about cyclins and cyclin-dependent kinases in differentiated cells and explores the possibility that these proteins may have important functions that are independent of cell cycle regulation.
Gao
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CY
Laboratory of Molecular and Developmental Biology, National Eye Institute, NIH, Bethesda, MD 20892-2730, USA.
Zelenka
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PS
D000818:Animals; D017209:Apoptosis / Q000502:physiology; D002454:Cell Differentiation / Q000502:physiology*; D018844:Cyclin-Dependent Kinases / Q000145:classification / Q000235:genetics / Q000502:physiology*; D016213:Cyclins / Q000145:classification / Q000235:genetics / Q000502:physiology*; D018507:Gene Expression Regulation, Developmental; D008954:Models, Biological; D005810:Multigene Family; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism; D014158:Transcription, Genetic
D016213:Cyclins; D018844:Cyclin-Dependent Kinases