title: The development and evaluation of a diluter-ultraviolet spectrophotometric analysis system for the determination of drugs in solutions and suspensions.
abstract: An automated system has been developed and validated for the analysis of liquid formulations (solution and suspension). The system comprises a multi-place magnetic stirrer, a diluter and a diode array UV spectrophotometer. The system can handle a wide range of drug formulation concentrations (> 200 mg ml-1) and gives excellent precision and accuracy with no detectable carryover. The analysis acceptance parameters are user-definable and the analysis process, including interpretation and reporting of the data, is fully automated.
authors.affiliation: Safety of Medicines Department, Zeneca Pharmaceuticals, Alderley Park, Macclesfield, UK.
authors.forename: B
authors.initials: B
authors.lastname: Law
authors.forename: P
authors.initials: P
authors.lastname: Hough
mesh_terms: D002626:Chemistry, Pharmaceutical / Q000379:methods; D005069:Evaluation Studies as Topic; D004364:Pharmaceutical Preparations / Q000032:analysis*; D015203:Reproducibility of Results; D012996:Solutions; D013056:Spectrophotometry, Ultraviolet / Q000295:instrumentation / Q000379:methods*; D013535:Suspensions
chemical_list: D004364:Pharmaceutical Preparations; D012996:Solutions; D013535:Suspensions