Alpha-interferon and pregnancy in a patient with CML.
A 34-year-old woman on interferon for CML for 7 years, experienced problems with conception. Full work-up revealed a short luteal phase and therapy with clomiphene was initiated. Pregnancy occurred and a normal infant was delivered by C-section. The detailed infertility evaluation is described and the impact of interferon therapy on pregnancy is reviewed. Successful pregnancy appears possible in woman taking interferon on a chronic basis.
Lipton
J H
JH
Department of Medicine, Princess Margaret Hospital, Toronto, Ontario, Canada.
Derzko
C M
CM
Curtis
J
J
D000328:Adult; D000970:Antineoplastic Agents / Q000493:pharmacokinetics / Q000627:therapeutic use*; D018906:Antineoplastic Agents, Alkylating / Q000627:therapeutic use; D002996:Clomiphene / Q000627:therapeutic use; D005260:Female; D005300:Fertility Agents, Female / Q000627:therapeutic use; D006801:Humans; D006918:Hydroxyurea / Q000627:therapeutic use; D007231:Infant, Newborn; D007247:Infertility, Female / Q000188:drug therapy / Q000209:etiology; D016898:Interferon-alpha / Q000493:pharmacokinetics / Q000627:therapeutic use*; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000188:drug therapy*; D008297:Male; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D012074:Remission Induction
D000970:Antineoplastic Agents; D018906:Antineoplastic Agents, Alkylating; D005300:Fertility Agents, Female; D016898:Interferon-alpha; D002996:Clomiphene; D006918:Hydroxyurea