Na+,K(+)-ATPase activity in neurons and glial cells of the olfactory cortex of the rat brain during the development of long-term potentiation.
Na+,K(+)-ATPase and Mg(2+)-ATPase activities were studied in neurons and glial cells of the olfactory cortex of the rat by quantitative cytophotometry in conditions of long-term potentiation (LTP), and significant changes in direction and extent were found. Na+,K(+)-ATPase activity decreased in neurons in the first 15 min after LTP, with subsequent elevation by 30 min. Mg(2+)-ATPase activity remained unchanged in these conditions. Glial cells showed significant increases in Na+,K(+)-ATPase activity in the initial period after LTP, with return to control by 30 min. Again, there were no significant changes in Mg(2+)-ATPase activity. The formation and persistence of LTP in neurons and glial cells was accompanied by significant changes in Na+,K(+)-ATPase activity, which were reciprocal in nature.
Glushchenko
T S
TS
Functional Neurochemistry Laboratory, I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg.
Izvarina
N L
NL
D000818:Animals; D017301:Ca(2+) Mg(2+)-ATPase / Q000378:metabolism; D004558:Electric Stimulation; D017774:Long-Term Potentiation / Q000502:physiology*; D009457:Neuroglia / Q000201:enzymology* / Q000502:physiology; D009474:Neurons / Q000201:enzymology* / Q000502:physiology; D009833:Olfactory Pathways / Q000201:enzymology* / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*
D017301:Ca(2+) Mg(2+)-ATPase; D000254:Sodium-Potassium-Exchanging ATPase