title: Enterobacteria-infected T cells as antigen-presenting cells for cytotoxic CD8 T cells: a contribution to the self-limitation of cellular immune reactions in reactive arthritis?
abstract: In enterobacteria-induced reactive arthritis (ReA), different T cell subsets play a role in the induction and maintenance of the synovitic process. Synovial fluid-derived alphabeta CD4, alphabeta CD8, and gammadelta T lymphocyte clones (TLC) that recognize Yersinia or Salmonella antigens on professional antigen-presenting cells (APC) have been characterized, and T cells themselves can function as nonprofessional APC. T cells were infected with the facultatively intracellular, arthritogenic enterobacterium Yersinia enterocolitica O:3. A CD8 TLC isolated from a patient with Yersinia-induced ReA recognized and efficiently lysed autologous and allogeneic Yersinia-infected T cells. Infected cytotoxic T lymphocytes (CTL) had a reduced lytic capacity against syngeneic and allogeneic infected target cells, suggesting that the infection of CTL by bacteria may represent a mechanism of immune escape. In ReA, antigen presentation by T cells may modify the antibacterial immune response and may also contribute to network control mechanisms of T cell-mediated cytotoxicity.
authors.affiliation: First Department of Medicine, Johannes Gutenberg-University of Mainz, Germany.
authors.forename: B
authors.initials: B
authors.lastname: Ackermann
authors.forename: M S
authors.initials: MS
authors.lastname: Staege
authors.forename: A B
authors.initials: AB
authors.lastname: Reske-Kunz
authors.forename: H P
authors.initials: HP
authors.lastname: Dienes
authors.forename: K H
authors.initials: KH
authors.lastname: Meyer zum Büschenfelde
authors.forename: E
authors.initials: E
authors.lastname: Märker-Hermann
mesh_terms: D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology / Q000382:microbiology*; D000942:Antigens, Bacterial / Q000276:immunology*; D016918:Arthritis, Reactive / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology / Q000382:microbiology; D002999:Clone Cells; D006801:Humans; D007111:Immunity, Cellular; D007739:L Cells; D051379:Mice; D008854:Microscopy, Electron; D000091402:Prohibitins; D012486:Salmonella typhimurium / Q000276:immunology*; D016176:T-Lymphocyte Subsets / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology / Q000382:microbiology* / Q000648:ultrastructure; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology / Q000382:microbiology*; D014407:Tumor Cells, Cultured; D015009:Yersinia Infections / Q000276:immunology*; D015008:Yersinia enterocolitica / Q000276:immunology*
chemical_list: D000942:Antigens, Bacterial; C000717331:PHB2 protein, human; D000091402:Prohibitins