Effects of nifedipine and diltiazem on pharmacokinetics of cefpodoxime following its oral administration.
We compared the effects of nifedipine and diltiazem on the uptake of cefpodoxime proxetil (CP). The study was aimed at establishing the impact of increased mesenteric blood flow due to calcium channel blockers on passive transport. Twelve volunteers were given CP (200 mg) orally in a crossover design. The absorption, disposition, and elimination parameters of cefpodoxime were compared among the following three treatment groups: CP alone, CP following oral administration of diltiazem (60 mg), or CP following oral administration of nifedipine (20 mg). No statistically significant difference in pharmacokinetic parameters was observed between the three treatment groups.
Deslandes
A
A
Service de Pharmacie Clinique et des Biomatériaw, Institut National de la Santé et de la Recherche Médicale, Paris, France.
Camus
F
F
Lacroix
C
C
Carbon
C
C
Farinotti
R
R
D000284:Administration, Oral; D000328:Adult; D000900:Anti-Bacterial Agents / Q000097:blood / Q000493:pharmacokinetics*; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D015296:Ceftizoxime / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics; D018592:Cross-Over Studies; D004110:Diltiazem / Q000494:pharmacology*; D004347:Drug Interactions; D006801:Humans; D008297:Male; D009543:Nifedipine / Q000494:pharmacology*; D013152:Splanchnic Circulation / Q000187:drug effects; D000097627:Cefpodoxime Proxetil
D000900:Anti-Bacterial Agents; D002121:Calcium Channel Blockers; D015296:Ceftizoxime; D004110:Diltiazem; D009543:Nifedipine; D000097627:Cefpodoxime Proxetil