The development and evaluation of a diluter-ultraviolet spectrophotometric analysis system for the determination of drugs in solutions and suspensions.
An automated system has been developed and validated for the analysis of liquid formulations (solution and suspension). The system comprises a multi-place magnetic stirrer, a diluter and a diode array UV spectrophotometer. The system can handle a wide range of drug formulation concentrations (> 200 mg ml-1) and gives excellent precision and accuracy with no detectable carryover. The analysis acceptance parameters are user-definable and the analysis process, including interpretation and reporting of the data, is fully automated.
Law
B
B
Safety of Medicines Department, Zeneca Pharmaceuticals, Alderley Park, Macclesfield, UK.
Hough
P
P
D002626:Chemistry, Pharmaceutical / Q000379:methods; D005069:Evaluation Studies as Topic; D004364:Pharmaceutical Preparations / Q000032:analysis*; D015203:Reproducibility of Results; D012996:Solutions; D013056:Spectrophotometry, Ultraviolet / Q000295:instrumentation / Q000379:methods*; D013535:Suspensions
D004364:Pharmaceutical Preparations; D012996:Solutions; D013535:Suspensions