title: Synthesis of a new potent anti-angiogenic agent, 17 alpha-acetoxy-9 alpha-fluoro-6 alpha-methylprogesterone (9 alpha-fluoromedroxyprogesterone acetate [FMPA]).
abstract: A new anti-angiogenic agent, 17 alpha-acetoxy-9 alpha-fluoro-6 alpha-methylprogesterone (9 alpha-fluoromedoroxyprogesterone acetate [FMPA, 9] was synthetized in a 10-step sequence. FMPA (9) had about two orders of magnitude stronger anti-angiogenic activity than medroxyprogesterone acetate (MPA), as estimated in a bioassay involving chorioallantoic membranes of growing chick embryos.
authors.affiliation: Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, Hiroshima, Japan.
authors.forename: E
authors.initials: E
authors.lastname: Sugino
authors.forename: S
authors.initials: S
authors.lastname: Fujimori
authors.forename: S
authors.initials: S
authors.lastname: Hibino
authors.forename: T
authors.initials: T
authors.lastname: Choshi
authors.forename: Y
authors.initials: Y
authors.lastname: Ichihara
authors.forename: Y
authors.initials: Y
authors.lastname: Sato
authors.forename: T
authors.initials: T
authors.lastname: Yamaji
authors.forename: H
authors.initials: H
authors.lastname: Tsuboi
authors.forename: N
authors.initials: N
authors.lastname: Murata
authors.forename: M
authors.initials: M
authors.lastname: Uchida
authors.forename: M
authors.initials: M
authors.lastname: Shimamura
authors.forename: T
authors.initials: T
authors.lastname: Oikawa
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002642:Chick Embryo; D017258:Medroxyprogesterone Acetate / Q000494:pharmacology; D018919:Neovascularization, Physiologic / Q000187:drug effects*; D011374:Progesterone / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology
chemical_list: C105228:17-acetoxy-9-fluoro-6-methylprogesterone; D000970:Antineoplastic Agents; D011374:Progesterone; D017258:Medroxyprogesterone Acetate