title: Decreased in vitro fertilization efficiencies in the presence of specific cyritestin peptides.
abstract: Synthetic peptides corresponding to specific regions of the mouse acrosomal transmembrane protein cyritestin have been used as competitors in in vitro fertilization experiments. One peptide representing a putative egg-receptor binding site within the disintegrin domain of cyritestin lowered the fertilization rate to 30% of the normal value.
authors.affiliation: Institut für Genetik, Heinrich-Heine-Universität, Düsseldorf, Germany.
authors.forename: B
authors.initials: B
authors.lastname: Linder
authors.forename: U A
authors.initials: UA
authors.lastname: Heinlein
mesh_terms: D051722:ADAM Proteins; D000177:Acrosome / Q000737:chemistry; D000595:Amino Acid Sequence; D000818:Animals; D005260:Female; D005307:Fertilization in Vitro / Q000187:drug effects*; D008297:Male; D008562:Membrane Glycoproteins / Q000737:chemistry / Q000494:pharmacology*; D008666:Metalloendopeptidases / Q000737:chemistry / Q000494:pharmacology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008969:Molecular Sequence Data
chemical_list: D008562:Membrane Glycoproteins; D051722:ADAM Proteins; C499566:ADAM3A protein, human; C485429:Adam3 protein, mouse; D008666:Metalloendopeptidases