title: Neoplastic transformation of the pelvic pouch mucosa in patients with ulcerative colitis.
abstract: OBJECTIVE
  Some patients with ulcerative colitis (UC) receiving an ileal pelvic pouch with ileoanal anastomosis (IPAA) develop persistent severe villous atrophy in the pouch mucosa. To investigate if mucosal atrophy indicates a risk for subsequent neoplastic transformation of the ileal pouch mucosa, a follow-up study was undertaken.
  
  
  METHODS
  Seven patients with UC and an IPAA in whom persistent severe atrophy (type C) developed and 14 control patients with no or only slight atrophy (type A) were prospectively surveyed by flexible videoendoscopy with multiple biopsies for assessment of possible neoplastic changes.
  
  
  RESULTS
  The median time of the pouch in function was 9 years for both groups. Dysplasia was found in 5 of 7 patients in the type C group (71%) compared with none in the type A group (P < 0.001). Four patients had low-grade dysplasia, and 1 patient had sequential multifocal development into high-grade dysplasia. Multifocal DNA aneuploidy was found in 2 patients, 1 with low-grade and 1 with high-grade dysplasia.
  
  
  CONCLUSIONS
  Patients with UC and a long-standing IPAA who develop persistent severe mucosal atrophy are at risk also of neoplastic transformation of the pouch mucosa.
authors.affiliation: Department of Surgery, Karolinska Institute, Huddinge University Hospital, Sweden.
authors.forename: K
authors.initials: K
authors.lastname: Gullberg
authors.forename: D
authors.initials: D
authors.lastname: Ståhlberg
authors.forename: L
authors.initials: L
authors.lastname: Liljeqvist
authors.forename: B
authors.initials: B
authors.lastname: Tribukait
authors.forename: F P
authors.initials: FP
authors.lastname: Reinholt
authors.forename: B
authors.initials: B
authors.lastname: Veress
authors.forename: R
authors.initials: R
authors.lastname: Löfberg
mesh_terms: D000293:Adolescent; D000328:Adult; D000782:Aneuploidy; D001284:Atrophy; D002471:Cell Transformation, Neoplastic; D002648:Child; D003093:Colitis, Ulcerative / Q000235:genetics / Q000473:pathology* / Q000601:surgery*; D003106:Colon / Q000473:pathology; D004247:DNA / Q000235:genetics; D004724:Endoscopy; D005260:Female; D006801:Humans; D007413:Intestinal Mucosa / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011159:Population Surveillance; D016737:Proctocolectomy, Restorative; D011446:Prospective Studies; D012007:Rectum / Q000473:pathology
chemical_list: D004247:DNA