[Morphogenetic studies in oncology].
Our laboratory morphogenetic studies have shown that most esophageal and intestinal tumors arise de novo, i.e. they are not necessarily preceded by the so-called "precancerous lesions". This is particularly true in the case of soft-tissue sarcoma (malignant fibrous histiocytoma and malignant hemangioendothelioma) which never involve "presarcoma" development. However, those investigations provided morphological characteristics of such early preinvasive cancers as carcinoma in situ and superficial cancer. Histological studies showed malignant fibrous histiocytoma to be low-differentiated sarcoma of fibroblastic origin. Wide-range morphogenetic potentialities of derivatives of the neural crest (miogenic differentiation) and Muller's epithelium (manifestation of connective-tissue properties) during tumor growth were identified in the course of the histogenetic examination of Triton experimental tumor and electron microscopy investigation of endometrial and ovarian tumor cells cultured in soft agar.
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D000818:Animals; D002471:Cell Transformation, Neoplastic; D016889:Endometrial Neoplasms / Q000473:pathology; D004938:Esophageal Neoplasms / Q000473:pathology; D005260:Female; D006390:Hemangioendothelioma / Q000473:pathology; D018219:Histiocytoma, Benign Fibrous / Q000473:pathology; D007414:Intestinal Neoplasms / Q000473:pathology; D009374:Neoplasms, Experimental / Q000235:genetics / Q000473:pathology*; D010051:Ovarian Neoplasms / Q000473:pathology; D014407:Tumor Cells, Cultured