title: Reduction of oxazepam to desmethyldiazepam by human intestinal bacteria.
abstract: The biotransformation of oxazepam by Bifidobacterium bifidum was studied. The major metabolite was purified by chromatographic methods and found to be desmethyldiazepam using NMR, IR and other physicochemical data.
authors.affiliation: Osaka Perfectural Institute of Public Health, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Okamura
authors.forename: W
authors.initials: W
authors.lastname: Sugiura
authors.forename: M
authors.initials: M
authors.lastname: Miyazawa
mesh_terms: D001644:Bifidobacterium / Q000502:physiology; D001711:Biotransformation; D006801:Humans; D007422:Intestines / Q000382:microbiology*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D015394:Molecular Structure; D003708:Nordazepam / Q000378:metabolism*; D010076:Oxazepam / Q000378:metabolism*; D010084:Oxidation-Reduction; D013053:Spectrophotometry
chemical_list: D003708:Nordazepam; D010076:Oxazepam