title: T-cell receptors: is the repertoire inherently MHC-specific?
abstract: A debate over whether the observed specificity of the naive T-cell receptor repertoire for major histocompatibility complex molecules arises before or after selection within the thymus has apparently been settled in favour of the former by a series of new experiments.
authors.affiliation: Section of Immunobiology, Yale University School of Medicine and Howard Hughes Medical Institute, New Haven, Connecticut, 06520-8011, USA.
authors.forename: C A
authors.initials: CA
authors.lastname: Janeway
authors.forename: A V
authors.initials: AV
authors.lastname: Chervonsky
authors.forename: D
authors.initials: D
authors.lastname: Sant'Angelo
mesh_terms: D000818:Animals; D005805:Genes, MHC Class I; D005802:Genes, MHC Class II; D007108:Immune Tolerance; D008285:Major Histocompatibility Complex; D051379:Mice; D011948:Receptors, Antigen, T-Cell / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*; D013950:Thymus Gland / Q000276:immunology
chemical_list: D011948:Receptors, Antigen, T-Cell