title: Wada memory and timing of stimulus presentation.
abstract: We compared Wada memory performance for stimuli presented at two timing intervals following amobarbital injection in 47 non-lesional patients with complex partial seizures (L = 26; R = 21). A significant interaction between seizure focus and timing of presentation was present (P < 0.03). Memory performance for objects whose presentation began approximately 50-55 s following amobarbital administration differed as a function of ipsilateral vs. contralateral injection at a very high level of statistical significance (P < 0.00001). Items presented approximately 4 min, 30 s post injection were also related to seizure onset literality, but at a lower statistical level (P < 0.01). Presentation of Wada memory stimuli earlier during hemispheric anaesthesia yields results that are more sensitive to lateralized temporal lobe seizure onset than does presentation of items later during the procedure.
authors.affiliation: Department of Neurology, Medical College of Georgia, Augusta 30912-3275, USA.
authors.forename: D W
authors.initials: DW
authors.lastname: Loring
authors.forename: K J
authors.initials: KJ
authors.lastname: Meador
authors.forename: G P
authors.initials: GP
authors.lastname: Lee
authors.forename: M E
authors.initials: ME
authors.lastname: Nichols
authors.forename: D W
authors.initials: DW
authors.lastname: King
authors.forename: A M
authors.initials: AM
authors.lastname: Murro
authors.forename: Y D
authors.initials: YD
authors.lastname: Park
authors.forename: J R
authors.initials: JR
authors.lastname: Smith
mesh_terms: D000328:Adult; D000654:Amobarbital; D002339:Carotid Arteries; D003071:Cognition; D017029:Epilepsy, Complex Partial / Q000503:physiopathology / Q000523:psychology* / Q000601:surgery; D007839:Functional Laterality; D006801:Humans; D007269:Injections, Intra-Arterial; D008568:Memory; D009483:Neuropsychological Tests; D013702:Temporal Lobe / Q000601:surgery; D013997:Time Factors
chemical_list: D000654:Amobarbital