title: Intercellular adhesion molecule-1 in proliferative vitreoretinopathy.
abstract: OBJECTIVE
  To measure vitreous levels of the soluble intercellular adhesion molecule (sICAM-1) in eyes with rhegmatogenous retinal detachment (RRD) complicated or uncomplicated by proliferative vitreoretinopathy (PVR) to investigate whether levels of this molecule related to history of previous retinal surgery or to the duration and severity of PVR.
  
  
  METHODS
  The authors measured vitreous sICAM-1 by enzyme-linked immunosorbent assay in 28 eyes with PVR and 35 eyes with uncomplicated RRD. Vitreous from 10 eyes with macular holes and from 12 cadaveric eye donors were used as control specimens.
  
  
  RESULTS
  Vitreous sICAM-1 levels were higher in the group with RRD complicated by PVR as a whole than in the group with RRD alone or in the control groups. In patients with no previous retinal surgery, there was no difference in vitreous sICAM-1 levels between the groups with RRD alone and RRD complicated by PVR. However, in patients who had undergone previous external surgery, those with PVR showed higher levels of vitreous sICAM-1 than those with RRD alone. In PVR, raised levels of sICAM-1 were associated preferentially with a history of previous vitrectomy as well as with a longer duration of the condition, although these levels were not related to the grade of PVR. In eyes with RRD alone, the levels of sICAM-1 were not enhanced with the duration of the detachment. Despite showing high vitreous levels of sICAM-1, patients with PVR did not exhibit increased serum levels of this adhesion molecule.
  
  
  CONCLUSIONS
  The current observations suggest that those persons in whom PVR develops may have an impairment of the mechanisms that control the inflammatory response to retinal trauma. Persistently raised vitreous levels of sICAM-1 point to the continued operation of cytokine-mediated vascular reactions at the blood-retinal barrier.
authors.affiliation: Department of Immunology, St. Thomas' Hospital, UMDS, London, England.
authors.forename: G A
authors.initials: GA
authors.lastname: Limb
authors.forename: A H
authors.initials: AH
authors.lastname: Chignell
authors.forename: C J
authors.initials: CJ
authors.lastname: Cole
authors.forename: W T
authors.initials: WT
authors.lastname: Green
authors.forename: L
authors.initials: L
authors.lastname: Webster
authors.forename: R D
authors.initials: RD
authors.lastname: Hollifield
authors.forename: D C
authors.initials: DC
authors.lastname: Dumonde
mesh_terms: D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000378:metabolism*; D008297:Male; D012163:Retinal Detachment / Q000150:complications / Q000378:metabolism; D018630:Vitreoretinopathy, Proliferative / Q000209:etiology / Q000378:metabolism*; D014822:Vitreous Body / Q000378:metabolism
chemical_list: D018799:Intercellular Adhesion Molecule-1