Soluble interleukin-2 receptor in primary and secondary Sjögren's syndrome.
Serum levels of soluble interleukin-2 receptor (sIL2-R) were studied in patients with or without Sjögren's syndrome (SS). The mean sIL2-R level was significantly higher (P < 0.0001) in those with autoimmune diseases, whether with or without SS, than in healthy people. The serum level of sIL2-R did not help to distinguish primary from secondary SS, or the absence of this syndrome in patients with autoimmune diseases. We found a correlation between the sIL2-R level and the presence of SS-A and SS-B antibodies or antinuclear antibody levels, and no correlation with other serological and clinical markers. Salivary gland anomalies were always accompanied by high sIL2-R levels, but there was no correlation between sIL2-R levels and degree of glandular lesion. Routine determination of sIL2-R in patients with dry syndrome is likely to prove useful for ruling out SS without resorting to invasive testing.
Tomás
S
S
Department of Medicine, Hospital Mútua de Terrassa, Barcelona, Spain.
Coll
J
J
Palazón
X
X
D000974:Antibodies, Antinuclear / Q000032:analysis; D001327:Autoimmune Diseases / Q000097:blood; D015415:Biomarkers; D019084:Fluorescent Antibody Technique, Indirect; D006801:Humans; D007150:Immunohistochemistry; D015375:Receptors, Interleukin-2 / Q000032:analysis / Q000097:blood*; D012469:Salivary Glands / Q000276:immunology / Q000473:pathology; D012859:Sjogren's Syndrome / Q000097:blood* / Q000175:diagnosis / Q000209:etiology
D000974:Antibodies, Antinuclear; D015415:Biomarkers; D015375:Receptors, Interleukin-2; C035356:SS-A antibodies; C035357:SS-B antibodies