T-call development: is notch a key player in lineage decisions?
At two consecutive 'checkpoints' in their development, T cells have to be rescued from programmed cell death and to choose between distinct lineage fates; recent results show that the Notch transmembrane receptor can significantly influence T-cell development at both of these points.
von Boehmer
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Institut Necker, INSERM 373, Facult-e de M-edecine, Necker 156, rue de Vaugirard, F-75730, Paris Cedex 15, France.
D000818:Animals; D017209:Apoptosis; D016694:Gene Rearrangement, delta-Chain T-Cell Antigen Receptor; D015334:Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor; D008285:Major Histocompatibility Complex; D008565:Membrane Proteins / Q000276:immunology*; D018448:Models, Immunological; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000276:immunology; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000276:immunology; D011956:Receptors, Cell Surface / Q000276:immunology; D051880:Receptors, Notch; D016176:T-Lymphocyte Subsets / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology* / Q000502:physiology
D008565:Membrane Proteins; D016693:Receptors, Antigen, T-Cell, alpha-beta; D016692:Receptors, Antigen, T-Cell, gamma-delta; D011956:Receptors, Cell Surface; D051880:Receptors, Notch