Potassium and magnesium retaining triamterene derivatives.
This work represents a summary of studies carried out with potassium and magnesium retaining triamterene derivatives. The synthesis, analytics and physico-chemical characteristics of those substances are described. Furthermore, the relationships between the chemical structure and electrolyte excretion, pharmacokinetics, metabolism and toxicity are demonstrated. An expanded model regarding the mode of action of triamterene and its derivatives is also presented.
Priewer
H
H
Du Pont Pharma GmbH, Bad Homburg, Germany.
Ullrich
F
F
D000818:Animals; D004232:Diuretics / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D008274:Magnesium / Q000378:metabolism*; D011188:Potassium / Q000378:metabolism*; D014223:Triamterene / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology*
D004232:Diuretics; D008274:Magnesium; D011188:Potassium; D014223:Triamterene