Angioscopic assessment of coronary lesions underlying thrombus.
This study examines the characteristics of coronary lesions in which thrombus is found as assessed by angioscopy before percutaneous transluminal coronary angioplasty in patients with various coronary syndromes. Our findings demonstrate that the plaque underlying intracoronary thrombus is usually yellow and/or disrupted, and support in vitro observations that lipid-rich plaques are highly thrombogenic and that disruption of these plaques is associated with in situ thrombosis.
Waxman
S
S
Cardiovascular Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA.
Mittleman
M A
MA
Zarich
S W
SW
Fitzpatrick
P J
PJ
Lewis
S M
SM
Leeman
D E
DE
Shubrooks
S J
SJ
Snyder
J T
JT
Muller
J E
JE
Nesto
R W
RW
D017546:Angioscopy; D003327:Coronary Disease / Q000150:complications* / Q000175:diagnosis* / Q000209:etiology; D003328:Coronary Thrombosis / Q000209:etiology* / Q000473:pathology*; D006801:Humans; D012307:Risk Factors