Lactate transport across the bovine rumen epithelium in vitro.
The in vitro transport of L-lactate across rumen epithelium was found to be a passive, mass-action regulated diffusion, and no saturable transport mechanisms were involved at concentrations from 2-20 mmol/L. During this increase in L-lactate concentrations the epithelial resistance and potential difference increased significantly, indicating an epithelial change towards a more tight epithelium. The net sodium transport was significantly reduced by 45% at 20 mmol/L lactate as compared to lactate free conditions.
Møller
P D
PD
Department of Animal Physiology, Royal Veterinary and Agricultural University, Copenhagen, Denmark.
Diernaes
L
L
Sehested
J
J
Hyldgaard-Jensen
J
J
Skadhauge
E
E
D000818:Animals; D001692:Biological Transport / Q000187:drug effects / Q000502:physiology; D002417:Cattle / Q000378:metabolism* / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D004848:Epithelium / Q000378:metabolism / Q000502:physiology; D066298:In Vitro Techniques; D007773:Lactates / Q000378:metabolism / Q000493:pharmacokinetics* / Q000494:pharmacology; D012044:Regression Analysis; D012417:Rumen / Q000378:metabolism* / Q000502:physiology; D012964:Sodium / Q000378:metabolism / Q000493:pharmacokinetics
D007773:Lactates; D012964:Sodium