title: Brain monoamines and optokinetic performances in pigmented and albino rats.
abstract: The aim of this study was two-fold: 1) To provide in DA-HAN rats the basic brain monoamine data useful for later investigations of the neurochemical effects of sensory alterations and 2) to assess whether there is a relationship between the monoaminergic pattern in medial vestibular nuclei and optokinetic performances. We comparatively studied the regional brain monoamine distribution and the optokinetic performances in pigmented DA-HAN and albino Sprague-Dawley rats. As expected, the optokinetic responses and vestibulo-ocular reflex gain were by far more efficient in DA-HAN rats. Norepinephrine (NE), dopamine (DA), serotonin (5-HT) and their metabolites were determined in retina, brainstem nuclei and dopaminergic areas. DA-HAN rats exhibited an increased noradrenergic activity in the medial vestibular nuclei, locus coeruleus and anteroventral cochlear nucleus, an extended decrease of serotonergic activity in brainstem nuclei and increased DA stores with a reduced dopaminergic activity in most dopaminergic areas. These data confirm and extend the general findings that biochemical data obtained in one strain cannot be extrapolated to another strain. The possible role of the morphological neuronal abnormalities and functional impairment induced by albinism has been discussed especially in medial vestibular nucleus, cochlear nuclei and retina. Alternatively, behavioral factors may also explain some of the observed neurochemical differences.
authors.affiliation: URA CNRS 1447, Faculté de Médecine, Lyon, France.
authors.forename: H
authors.initials: H
authors.lastname: Cransac
authors.forename: L
authors.initials: L
authors.lastname: Peyrin
authors.forename: F
authors.initials: F
authors.lastname: Farhat
authors.forename: J M
authors.initials: JM
authors.lastname: Cottet-Emard
authors.forename: J M
authors.initials: JM
authors.lastname: Pequignot
authors.forename: A
authors.initials: A
authors.lastname: Reber
mesh_terms: D000417:Albinism / Q000378:metabolism / Q000503:physiopathology*; D000818:Animals; D015306:Biogenic Monoamines / Q000378:metabolism* / Q000502:physiology; D001923:Brain Chemistry / Q000502:physiology*; D017626:Cochlear Nucleus / Q000378:metabolism / Q000502:physiology; D004298:Dopamine / Q000378:metabolism / Q000502:physiology; D004594:Electrophysiology; D005133:Eye Movements / Q000502:physiology*; D008297:Male; D009419:Nerve Tissue Proteins / Q000378:metabolism; D009638:Norepinephrine / Q000378:metabolism / Q000502:physiology; D010858:Pigmentation / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012027:Reflex, Vestibulo-Ocular / Q000502:physiology; D012160:Retina / Q000378:metabolism / Q000502:physiology; D012701:Serotonin / Q000378:metabolism / Q000502:physiology
chemical_list: D015306:Biogenic Monoamines; D009419:Nerve Tissue Proteins; D012701:Serotonin; D004298:Dopamine; D009638:Norepinephrine