Evidence for antiradical and antioxidant properties of four biologically active N,N-diethylaminoethyl ethers of flavanone oximes: a comparison with natural polyphenolic flavonoid (rutin) action.
The antiradical and antioxidant activities of four biologically active N,N-diethyloaminoethyl ethers of flavanone oximes (N,N-DEAEFo) were investigated in vitro and compared with these of polyphenolic flavonoid (rutin). Four experimental models were used: iron- and ascorbate driven Fenton systems, gamma-radiolysis, xanthine/xanthine oxidase system and diphenylpicrylhydrazyl (DPPH) radical scavenging. The results clearly indicate that N,N-DEAEFo are acting as promising antioxidants and radioprotectors comparable to rutin activities: they should prove to be useful under acute oxidative stress conditions for which both properties were required.
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Institute of Applied Radiation Chemistry, Technical University of Lódź, Poland. media@mitr.p.lodz.pl
Kochman
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Karolczak
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D000975:Antioxidants / Q000494:pharmacology*; D044950:Flavanones; D005419:Flavonoids / Q000494:pharmacology*; D016166:Free Radical Scavengers / Q000494:pharmacology; D007501:Iron / Q000494:pharmacology; D007502:Iron Chelating Agents / Q000494:pharmacology; D010091:Oximes / Q000494:pharmacology*; D012431:Rutin / Q000494:pharmacology*
D000975:Antioxidants; D044950:Flavanones; D005419:Flavonoids; D016166:Free Radical Scavengers; D007502:Iron Chelating Agents; D010091:Oximes; D012431:Rutin; D007501:Iron; C028610:flavanone