Lysosomal membrane stabilization by alpha-tocopherol against the damaging action of Vipera russelli venom phospholipase A2.
This investigation shows the membrane stabilizing effect of alpha-tocopherol against the damaging action of viper venom phospholipase A2 (PLA2). Liver lysosomal membranes from rats fed 100 mg and 200 mg alpha-tocopherol acetate per kilogram of diet were more resistant to damage by viper venom PLA2 compared with vitamin E-deficient rats. The membrane stabilizing effect of vitamin E is proposed to be due to the formation of a complex with the phospholipid hydrolysis products of the membrane.
Mukherjee
A K
AK
Department of Biochemistry, Burdwan Medical College, India.
Ghosal
S K
SK
Maity
C R
CR
D000818:Animals; D004032:Diet; D005260:Female; D007425:Intracellular Membranes / Q000187:drug effects; D008247:Lysosomes / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D010741:Phospholipases A / Q000494:pharmacology*; D054467:Phospholipases A2; D051381:Rats; D017208:Rats, Wistar; D017840:Daboia; D014757:Viper Venoms / Q000201:enzymology / Q000494:pharmacology*; D014810:Vitamin E / Q000097:blood / Q000494:pharmacology*; D014811:Vitamin E Deficiency
D014757:Viper Venoms; D014810:Vitamin E; D010741:Phospholipases A; D054467:Phospholipases A2