Effect of N,N-dimethylalkylamine N-oxides on the activity of purified sarcoplasmic reticulum (Ca-Mg)ATPase.
Amphiphilic N,N-dimethylalkylamine N-oxides (abbreviation CnNO, n is the number of carbon atoms in the alkyl substituent) modulate the activity of the purified sarcoplasmic reticulum (Ca-Mg)ATPase. The phase of insensivity or slight stimulation of the activity at lower homologue concentrations is followed by the inhibition phase at higher concentrations. The potency to inhibit at high concentrations is maximal for the homologue with the alkyl chain length n = 16. The inhibition could be caused by the binding of homologues to binding sites at the protein/lipid bilayer interface.
Andriamainty
F
F
Faculty of Pharmacy, J. A. Comenius University, Bratislava, Slovak Republic.
Filípek
J
J
Devínský
F
F
Balgavý
P
P
D000588:Amines / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D017301:Ca(2+) Mg(2+)-ATPase / Q000037:antagonists & inhibitors*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D005260:Female; D066298:In Vitro Techniques; D008051:Lipid Bilayers / Q000737:chemistry; D010087:Oxides / Q000138:chemical synthesis* / Q000494:pharmacology; D011817:Rabbits; D012519:Sarcoplasmic Reticulum / Q000187:drug effects / Q000201:enzymology*; D014961:X-Ray Diffraction
D000588:Amines; D004791:Enzyme Inhibitors; D008051:Lipid Bilayers; D010087:Oxides; D017301:Ca(2+) Mg(2+)-ATPase