Lymphocyte activation in allergic reactions elicited by small-molecular-weight compounds.
The involvement of cytochrome-P450-dependent metabolism of small-molecular-weight compounds as a prerequisite for an optimal lymphocyte response to those compounds is discussed on the basis of studies with compound such as p-phenylenediamine, sulfamethoxazole, chloramphenicol and fragrances. Subsequently, data on cytochrome P450 activity and CYP gene expression in monocytes and MAC-6 cells for cytochromes P450 2E1 and 3A4 are presented.
Merk
H F
HF
Department of Dermatology, University Hospital, RWTH Aachen, Germany.
Baron
J
J
Hertl
M
M
Niederau
D
D
Rübben
A
A
D002701:Chloramphenicol / Q000276:immunology; D003577:Cytochrome P-450 Enzyme System / Q000502:physiology; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology*; D008213:Lymphocyte Activation; D008970:Molecular Weight; D009000:Monocytes / Q000201:enzymology; D010655:Phenylenediamines / Q000276:immunology; D013449:Sulfonamides / Q000276:immunology
D010655:Phenylenediamines; D013449:Sulfonamides; D002701:Chloramphenicol; D003577:Cytochrome P-450 Enzyme System; C029728:4-phenylenediamine