title: [Manifestations of immunopathology and validation of immunotherapy of diabetic retinopathy].
abstract: Three-year clinical and immunological studies of 378 patients with diabetic retinopathy revealed involvement of the T- and B-immunity systems and the specific features of the local autoimmune response to the retinal S-antigen, which manifest during the early preclinical stage of diabetic retinopathy. The progress of retinopathy is associated with augmenting insufficiency of T-suppressors, inhibition of lymphocyte blastogenesis with phytohemagglutinin, and an increase in the levels of B-lymphocytes, IgM, and circulating immune complexes in the blood. Two abnormalities of autoimmune response of the eye to S-antigen were observed in patients with the proliferative forms: hypersensitivity and insufficiency of the immune response. A moderate level of S-antigen in tears is a protective factor, stabilizing retinopathy. The authors validate the significance of immunological test for predicting the course of retinopathy and emphasize the differentiated approach to local and total-system's correction of immune disorders in diabetics.
authors.forename: N S
authors.initials: NS
authors.lastname: Zaĭtseva
authors.forename: L K
authors.initials: LK
authors.lastname: Dudnikova
authors.forename: O S
authors.initials: OS
authors.lastname: Slepova
authors.forename: L S
authors.initials: LS
authors.lastname: Li
authors.forename: N B
authors.initials: NB
authors.lastname: Smirnova
authors.forename: M V
authors.initials: MV
authors.lastname: Zueva
authors.forename: G R
authors.initials: GR
authors.lastname: Kalamkarov
authors.forename: T F
authors.initials: TF
authors.lastname: Shevchenko
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001402:B-Lymphocytes / Q000276:immunology; D002648:Child; D003930:Diabetic Retinopathy / Q000276:immunology* / Q000628:therapy; D006801:Humans; D007167:Immunotherapy; D008875:Middle Aged; D011379:Prognosis; D013601:T-Lymphocytes / Q000276:immunology; D013666:Tears / Q000276:immunology; D013997:Time Factors