A two-backbone polymer model for interphase chromosome geometry.
A polymer model for the overall geometric structure of a human chromosome during the G0/G1 portion of cell-cycle interphase is constructed, based on fluorescence in situ hybridization data on distances between defined genomic sequences. The model consists of flexible giant loops, averaging about 6 million base pairs, with two random-walk backbones; it involves essentially three parameters. Numerical results based on properly selected values of parameters fit the data well.
Liu
B
B
Department of Mathematics, College of St. Scholastica, Duluth, MN 55811, USA. bliu@facl.css.edu
Sachs
R K
RK
D002877:Chromosomes, Human / Q000235:genetics / Q000648:ultrastructure*; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007399:Interphase; D008433:Mathematics; D008957:Models, Genetic; D011108:Polymers
D011108:Polymers