title: Tinospora cordifolia induces colony stimulating activity in serum.
abstract: Tinospora cordifolia (Tc) is an Indian medicinal plant with proven immunomodulatory activity. This study was performed to elucidate its possible mechanism of action. We measured CFU-GM Cotony forming units of the granulocyte-macrophage series in serum of mice treated with Tc. We found that 10 days treatment with Tc (100 mg/ kg/d) induced a significant (p < 0.01) increase in the number of CFU-GM (255 +/- 49.32 vs 38.51 +/- 9.98) This suggests that activation of macrophages by Tc leads to increase in GM-CSF which leads to leucocytosis and improved neutrophil function.
authors.affiliation: Dept of Pharmacology, Seth GS Medical College, Parel, Bombay, Maharashtra.
authors.forename: U M
authors.initials: UM
authors.lastname: Thatte
authors.forename: S G
authors.initials: SG
authors.lastname: Rao
authors.forename: S A
authors.initials: SA
authors.lastname: Dahanukar
mesh_terms: D000276:Adjuvants, Immunologic; D000818:Animals; D005260:Female; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000097:blood*; D008262:Macrophage Activation; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D010946:Plants, Medicinal
chemical_list: D000276:Adjuvants, Immunologic; D016178:Granulocyte-Macrophage Colony-Stimulating Factor