Transcriptional expression of gastrin mRNA in Helicobacter pylori infected patients.
In order to study the association between gastrin and H. pylori infection the density of antral G cells was evaluated by transcriptional expression of gastrin mRNA using a sensitive cold probe labelled with digoxigenin. the study group included 22 patients with symptomatic H. pylori positive gastritis and/or duodenal ulcer, 12 of whom were re-evaluated after eradication of H. pylori and 6 controls. The number of G cells per high power field in H.pylori positive patients (26.68 +/- 9.51) was significantly higher (P < 0.01) compared to controls (5.83 +/- 3.37). Among the 12 patients re-evaluated after H. pylori eradication, there was a significant decrease (P < 0.001) in the number of G cells (13.5 +/- 5.44) compared to pre-eradication value (26.25 +/- 8.0). The present study suggests that increased transcriptional expression of gastrin is directly related to H. pylori infection.
Gupta
A
A
Department of Experimental Medicine, Postgraduate Institute of Medical Education & Research, Chandigarh.
Rana
S V
SV
Goenka
M K
MK
Kukreja
R S
RS
D000293:Adolescent; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D005260:Female; D005755:Gastrins / Q000235:genetics*; D016481:Helicobacter Infections / Q000378:metabolism*; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D008875:Middle Aged; D012333:RNA, Messenger / Q000096:biosynthesis*; D014158:Transcription, Genetic
D005755:Gastrins; D012333:RNA, Messenger