Recurrent type III membranoproliferative glomerulonephritis after kidney transplantation.
The first well-documented case of recurrent type III membranoproliferative glomerulonephritis after kidney transplantation is reported in this article. A 48-year-old man was admitted to the hospital because of nephrotic syndrome and moderate renal failure. The renal biopsy showed double-contour images at light microscopy. Electron microscopy revealed electron-dense deposits in the mesangium and in both the subepithelial and subendothelial sides of the basement membrane. Subepithelial deposits were sometimes hump-like and produced an irregular disruption of the lamina densa. A diagnosis of type III membranoproliferative glomerulonephritis was suggested. The patient had a rapid decrease in renal function and received dialysis in 3 months. Three years later, he received a cadaveric kidney transplant, and subsequently recovered normal renal function. Proteinuria appeared after 13 months, and a biopsy of the graft demonstrated recurrence of the original disease. Seven years after transplantation, he returned to hemodialysis.
Morales
J M
JM
Department of Nephrology, Hospital Universitario 12 de Octubre, Madrid, Spain.
Martinez
M A
MA
Muñoz de Bustillo
E
E
Muñoz
M A
MA
Gota
R
R
Usera
G
G
D001706:Biopsy; D015432:Glomerulonephritis, Membranoproliferative / Q000209:etiology*; D006801:Humans; D007672:Kidney Cortex / Q000473:pathology / Q000648:ultrastructure; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D012008:Recurrence