title: Serum calcium and vitamin D status of patients with sickle cell disease in Curaçao.
abstract: We measured parameters of calcium homeostasis and vitamin D status in HbSS patients (median age 8 years, range 3-19; 8 females, 10 males) and matched HbAA controls living in the tropical island of Curaçao. Serum calcium concentration in HbSS patients [2.32(0.07)mmol/L] was lower (ANCOVA, P = 0.002) than that of HbAA controls [2.44(0.14)]. None of the subjects had hypocalcaemia. There were no differences in serum concentrations of phosphate, total protein, albumin, intact parathyroid hormone (PTH), 25-hydroxyvitamin D [87(27) nmol/L in patients, 86(15) nmol/L in controls) and 1,25-dihydroxyvitamin D. There were no significant relations between PTH and 25(OH)D. We conclude that vitamin D status of HbSS patients in Curaçao is adequate.
authors.affiliation: Central Laboratory for Clinical Chemistry, University Hospital, Groningen, The Netherlands.
authors.forename: F P
authors.initials: FP
authors.lastname: van der Dijs
authors.forename: F R
authors.initials: FR
authors.lastname: van der Klis
authors.forename: F D
authors.initials: FD
authors.lastname: Muskiet
authors.forename: F A
authors.initials: FA
authors.lastname: Muskiet
mesh_terms: D000293:Adolescent; D000328:Adult; D000755:Anemia, Sickle Cell / Q000097:blood*; D001798:Blood Proteins / Q000032:analysis; D002112:Calcifediol / Q000097:blood; D002117:Calcitriol / Q000097:blood; D002118:Calcium / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006706:Homeostasis; D006801:Humans; D008297:Male; D010281:Parathyroid Hormone / Q000097:blood; D010710:Phosphates / Q000097:blood; D015203:Reproducibility of Results; D014807:Vitamin D / Q000097:blood*; D014900:West Indies
chemical_list: D001798:Blood Proteins; D010281:Parathyroid Hormone; D010710:Phosphates; D014807:Vitamin D; D002117:Calcitriol; D002112:Calcifediol; D002118:Calcium