title: [Cerebrospinal fluid in the diagnosis of cerebro-meningeal metastasis from malignant melanoma arising from giant congenital melanocytic nevus: case report].
abstract: We describe the case of a 28-year-old man with a giant congenital melanocytic nevus (GCMN) with malignant transformation to melanoma and metastasis on the central nervous system (CNS). We also make a summary of the pathological features from both lesions (GCMN and Melanoma), the occurrence of malignancy of GCMN, the organs more frequently involved with metastatic melanoma--with emphasis to involvement of CNS--just as the factors that cause malignant transformation of GCMN; the methods to diagnose metastases in CNS--emphasizing the importance of cerebrospinal fluid--and some therapeutical modalities for the metastatic melanoma in CNS.
authors.affiliation: Escola Paulista de Medicina (EPM) da Universidade Federal de São Paulo(UNIFESP), Brasil.
authors.forename: J A
authors.initials: JA
authors.lastname: Rolim
authors.forename: O G
authors.initials: OG
authors.lastname: Barsottini
authors.forename: G F
authors.initials: GF
authors.lastname: Prado
authors.forename: F
authors.initials: F
authors.lastname: Nakandakare
authors.forename: M L
authors.initials: ML
authors.lastname: Reis
authors.forename: J B
authors.initials: JB
authors.lastname: Reis-Filho
mesh_terms: D000328:Adult; D001932:Brain Neoplasms / Q000134:cerebrospinal fluid* / Q000175:diagnosis / Q000556:secondary*; D006801:Humans; D008297:Male; D008545:Melanoma / Q000473:pathology*; D008577:Meningeal Neoplasms / Q000134:cerebrospinal fluid* / Q000175:diagnosis / Q000556:secondary*; D009378:Neoplasms, Multiple Primary / Q000473:pathology*; D009508:Nevus, Pigmented / Q000151:congenital* / Q000473:pathology*; D012878:Skin Neoplasms / Q000151:congenital* / Q000473:pathology*