[Monoamines, monoamine metabolites, neuron specific enolase and myelin basic protein concentrations in cerebrospinal fluid of resuscitated patients].
Changes of monoamines, monoamine metabolites, neuron specific enolase (NSE) and myelin basic protein (MBP) levels in cerebrospinal fluid were measured in 8 patients for up to 7 days after cardiopulmonary resuscitation. The outcomes were assessed by the Glasgow Outcome Scale. One showed good recovery 3 developed a persistent vegetate state (PVS) and 4 became brain dead (BD). The concentration of NSE increased to a peak about 3 days after resuscitation, then gradually decreased. MBP also showed an increase with time up to 7 days. The time course suggests that neuronal and/or axonal damage progresses for several days after hypoxic or anoxic brain insult. NSE and MBP in the BD group were higher than those in the PVS group, thus CSF levels may be prognostic with regard to hypoxic brain injury. Tyrosine, dopamine, 3-methoxytyramine (3-MT), 3-dihydroxy-4-phenylacetic acid (DOPAC), homovanillic acid (HVA), vanillylmanderic acid (VMA), normetanephrine (NMN), metanephrine (MN), 3-methoxy-4-hydroxyphenylglycol (MHPG), vanillic acid (VA), tryptophan and 5-hydroxyindoleacetic acid (5-HIAA) concentrations were analyzed by HPLC with an electrochemical detector. Concentrations changed within 2 or 3 days after resuscitation, so concentrations at that period may indicate neuronal damage. However, there are some cases with abnormal NSE and MBP levels without abnormal monoamine levels, suggesting that differences in concentrations are not the consequence of the amount of affected neurons, but of the sites of regions.
Takahashi
T
T
Department of Neuropsychiatry, Tokyo Medical College, Japan.
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015306:Biogenic Monoamines / Q000134:cerebrospinal fluid* / Q000378:metabolism; D001926:Brain Death / Q000134:cerebrospinal fluid; D016887:Cardiopulmonary Resuscitation; D004298:Dopamine / Q000031:analogs & derivatives / Q000134:cerebrospinal fluid; D005260:Female; D015600:Glasgow Coma Scale; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000134:cerebrospinal fluid; D002534:Hypoxia, Brain / Q000134:cerebrospinal fluid* / Q000209:etiology; D008297:Male; D008676:Metanephrine / Q000134:cerebrospinal fluid; D008734:Methoxyhydroxyphenylglycol / Q000134:cerebrospinal fluid; D008875:Middle Aged; D004676:Myelin Basic Protein / Q000134:cerebrospinal fluid*; D018458:Persistent Vegetative State / Q000134:cerebrospinal fluid; D010751:Phosphopyruvate Hydratase / Q000134:cerebrospinal fluid*; D011379:Prognosis; D013997:Time Factors; D016896:Treatment Outcome; D014364:Tryptophan / Q000134:cerebrospinal fluid; D014443:Tyrosine / Q000134:cerebrospinal fluid; D014641:Vanillic Acid / Q000134:cerebrospinal fluid
D015306:Biogenic Monoamines; D004676:Myelin Basic Protein; D014443:Tyrosine; D008676:Metanephrine; D008734:Methoxyhydroxyphenylglycol; D006897:Hydroxyindoleacetic Acid; D014364:Tryptophan; D010751:Phosphopyruvate Hydratase; D014641:Vanillic Acid; C001746:3-methoxytyramine; D004298:Dopamine