title: Subcutaneous crystal-storing histiocytosis associated with lymphoplasmacytic lymphoma (immunocytoma)
abstract: A case of massive crystal-storing histiocytosis with extensive involvement of the subcutaneous adipose tissue in a 61-year-old caucasian woman with a lymphoplasmacytic lymphoma (immunocytoma) in transformation to a large cell lymphoma is presented. Paraffin-section immunohistochemistry demonstrated a monoclonal IgM/ kappa immunphenotype of the lymphoma cells and revealed IgM/kappa and, to a lesser extent, IgG/lambda in the crystal-containing histiocytes. Ultrastructurally, the electron dense intracytoplasmic crystals had variables shapes, were occasionally membrane-bound and measured up to 6 microns. The finding are briefly discussed.
authors.affiliation: Institute of Pathology, Charité University Hospital, Berlin, Germany.
authors.forename: O
authors.initials: O
authors.lastname: Kaufmann
authors.forename: A
authors.initials: A
authors.lastname: Hansen
authors.forename: P
authors.initials: P
authors.lastname: Deicke
authors.forename: G R
authors.initials: GR
authors.lastname: Burmester
authors.forename: M
authors.initials: M
authors.lastname: Dietel
mesh_terms: D003460:Crystallization; D005260:Female; D015614:Histiocytosis / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007136:Immunoglobulins / Q000378:metabolism; D007150:Immunohistochemistry; D002479:Inclusion Bodies / Q000378:metabolism; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000150:complications* / Q000473:pathology; D008854:Microscopy, Electron; D008875:Middle Aged; D012871:Skin Diseases / Q000150:complications* / Q000378:metabolism / Q000473:pathology
chemical_list: D007136:Immunoglobulins