title: Anticipation of onset age in hereditary essential tremor.
abstract: The genetic anticipation phenomenon has been described in several neurological disorders, often associated with unstable trinucleotide repeats in the affected genes. The occurrence of this phenomenon in hereditary essential tremor is still debated. We describe a family in which three male members with essential tremor showed a progressive anticipation in onset age and an increased severity of clinical symptomatology.
authors.affiliation: Dipartimento di Scienze Neurologiche; V Clinica Neurologica, Università degli Studi di Roma La Sapienza, Roma, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Bragoni
authors.forename: G
authors.initials: G
authors.lastname: Fabbrini
authors.forename: S
authors.initials: S
authors.lastname: Di Legge
authors.forename: M
authors.initials: M
authors.lastname: Altieri
authors.forename: V
authors.initials: V
authors.lastname: Di Piero
mesh_terms: D000328:Adult; D002492:Central Nervous System Depressants / Q000494:pharmacology; D000431:Ethanol / Q000494:pharmacology; D006225:Hand / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D011597:Psychomotor Performance / Q000187:drug effects; D014202:Tremor / Q000235:genetics* / Q000503:physiopathology
chemical_list: D002492:Central Nervous System Depressants; D000431:Ethanol