title: Age-related changes in the compound action potentials of the eighth nerve in guinea pigs.
abstract: The eighth nerve compound action potential (CAP) in 95 guinea pigs was measured using click stimuli to investigate age-related changes in their neural auditory thresholds. The animals were separated into three groups: group A (n = 43, 86 ears; 2-4 months old); group B (n = 29; 58 ears, 13-15 months old); and group C (n = 23; 46 ears, 23-25 months old). With increasing age, a gradual elevation of CAP thresholds was clearly seen among the three groups. The negative peak (N1) latencies of the CAP were prolonged, and the N1 amplitudes of the CAP decreased. There were significant differences in N1 latencies among the three groups and in N1 amplitudes between groups A and B, and between groups A and C. However, the rate of decline of the thresholds as well as the input-output function curves of the CAP varied in some of the oldest animals, suggesting that there were some individual differences in degenerative aging processes of the auditory system.
authors.affiliation: Department of Otorhinolaryngology, Yamanashi Medical University, Japan.
authors.forename: I
authors.initials: I
authors.lastname: Nozawa
authors.forename: S
authors.initials: S
authors.lastname: Imamura
authors.forename: K
authors.initials: K
authors.lastname: Hashimoto
authors.forename: S
authors.initials: S
authors.lastname: Shimomura
authors.forename: Y
authors.initials: Y
authors.lastname: Murakami
mesh_terms: D000161:Acoustic Stimulation; D000818:Animals; D001309:Auditory Threshold / Q000502:physiology*; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D006168:Guinea Pigs; D011930:Reaction Time / Q000502:physiology; D012016:Reference Values; D000159:Vestibulocochlear Nerve / Q000502:physiology*