A summary statistic for measuring change from baseline.
A statistic, W, for measuring change from baseline is developed. Its distribution is found. Simulations using W and analysis of covariance (ANCOVA) are run and the results are compared. W is found to be less powerful than ANCOVA, yet is not seen to suffer some of the ill effects to which ANCOVA can fall prey, namely bias introduced by chance covariate imbalance.
Donahue
R M
RM
GlaxoWellcome, Research Triangle Park, North Carolina 27709, USA.
D000704:Analysis of Variance; D002986:Clinical Trials as Topic / Q000706:statistics & numerical data*; D003198:Computer Simulation; D003627:Data Interpretation, Statistical; D011336:Probability; D012107:Research Design