The Yin-Yang of cobalamin biochemistry.
The cobalamins are B12 cofactors with a reactive cobalt-carbon bond at their core and support the activity of two mammalian enzymes that are both medically important. The reactive organometallic bond of the cofactor can be cleaved either homolytically or heterolytically, but what determines how the enzymes control the fate of this bond?
Banerjee
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Biochemistry Department University of Nebraska Lincoln, NE 68588-0664, USA.
D013766:5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase / Q000737:chemistry / Q000378:metabolism; D014805:Vitamin B 12 / Q000737:chemistry / Q000378:metabolism*
D013766:5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; D014805:Vitamin B 12