Behavioural phenotypes and family stress in three mental retardation syndromes.
The behavioural phenotype of 30 fragile-X, 35 Prader-Willi and 35 Williams-Beuren syndrome children was explored using a psychometric approach. Results confirmed some distinct behaviours as syndrome-specific, but revealed a high degree of within-syndrome variability and overlap between syndromes as well. Parental stress was high in each of the groups, but was mediated by maternal dissatisfaction with family relationships. A multimethod approach with detailed syndrome-specific observations is recommended for further research.
Sarimski
K
K
Kinderzentrum, München, Germany.
D002648:Child; D002653:Child Behavior Disorders / Q000235:genetics* / Q000523:psychology; D002675:Child, Preschool; D017281:Cost of Illness; D005260:Female; D005600:Fragile X Syndrome / Q000235:genetics* / Q000523:psychology; D006801:Humans; D007223:Infant; D008607:Intellectual Disability / Q000235:genetics* / Q000523:psychology; D008297:Male; D010552:Personality Assessment / Q000706:statistics & numerical data; D010641:Phenotype; D011218:Prader-Willi Syndrome / Q000235:genetics* / Q000523:psychology; D011594:Psychometrics; D013315:Stress, Psychological / Q000150:complications*; D018980:Williams Syndrome / Q000235:genetics* / Q000523:psychology