Predominant role of local immunosuppressive effect in enhanced efficacy of liposomal FK506 in organ transplantation.
Liposomal FK506 is a new formulation of FK506 that increases FK506 levels in the liver and decreases them in the kidney in comparison to conventional IV formulation. In the present study, the efficacy of liposomal FK506 was evaluated in canine kidney and liver transplantation models. Liposomal FK506 increased the immunosuppressive efficacy of FK506 in the liver transplantation model, but decreased it in the kidney transplantation model. These results suggest that local immunosuppressive effects with increased intragraft FK506 level would play an important role in enhancing the immunosuppressive efficacy of liposomal FK506 in liver transplantation.
Ko
S
S
First Department of Surgery, Nara Medical University, Kashihara, Japan.
Nakajima
Y
Y
Kanehiro
H
H
Hisanaga
M
M
Horikawa
M
M
Aomatsu
Y
Y
Yagura
K
K
Kin
T
T
Ohyama
T
T
Nishio
K
K
Yamada
T
T
Nakano
H
H
D000818:Animals; D004285:Dogs; D004337:Drug Carriers; D005260:Female; D006085:Graft Survival; D007166:Immunosuppressive Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000627:therapeutic use; D007262:Infusions, Intravenous; D016030:Kidney Transplantation / Q000276:immunology*; D008081:Liposomes; D016031:Liver Transplantation / Q000276:immunology*; D008297:Male; D016559:Tacrolimus / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000627:therapeutic use
D004337:Drug Carriers; D007166:Immunosuppressive Agents; D008081:Liposomes; D016559:Tacrolimus