Genetic markers in primary open-angle glaucoma.
OBJECTIVE
To investigate possible associations between genetic markers and Primary Open-Angle Glaucoma (POAG).


METHODS
A number of genetic markers were typed in 84 unrelated patients with POAG and compared with a random sample of healthy individuals. The markers were Transferrin, Group Specific Component, G1m (1), G1m (2) and G3m (5) Allotypes, Adenylate Kinase, Adenosin Deaminase, Glyoxalase I and Acid Phosphatase and PCR-based markers HLA-DQA1 and D1S80.


RESULTS
No significant differences were found except the strong association between the group of POAG patients and Acid Phosphatase ACP*C allele (chi 2 = 32.86; p < 0.0001).


CONCLUSIONS
Since Acid Phosphatase gene is localized to chromosome 2p23, this result could be a first comprehensive step in the localization of POAG genes.
Abecia
E
E
Department of Ophthalmology, 'Miguel Servet' Hospital, Zaragoza, Spain.
Martínez-Jarreta
B
B
Casalod
Y
Y
Bell
B
B
Pinilla
I
I
Honrubia
F M
FM
D000135:Acid Phosphatase / Q000235:genetics; D000243:Adenosine Deaminase / Q000235:genetics; D000263:Adenylate Kinase / Q000235:genetics; D004247:DNA / Q000032:analysis*; D017931:DNA Primers / Q000737:chemistry; D004591:Electrophoresis, Polyacrylamide Gel; D005787:Gene Frequency / Q000235:genetics*; D005819:Genetic Markers; D005902:Glaucoma, Open-Angle / Q000235:genetics*; D006683:HLA-DQ Antigens / Q000235:genetics; D059848:HLA-DQ alpha-Chains; D006801:Humans; D007129:Immunoglobulin Gm Allotypes / Q000235:genetics; D007791:Lactoylglutathione Lyase / Q000235:genetics; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012307:Risk Factors; D014168:Transferrin / Q000235:genetics; D014809:Vitamin D-Binding Protein / Q000235:genetics
D017931:DNA Primers; D005819:Genetic Markers; D006683:HLA-DQ Antigens; D059848:HLA-DQ alpha-Chains; C069050:HLA-DQA1 antigen; D007129:Immunoglobulin Gm Allotypes; D014168:Transferrin; D014809:Vitamin D-Binding Protein; D004247:DNA; D000263:Adenylate Kinase; D000135:Acid Phosphatase; D000243:Adenosine Deaminase; D007791:Lactoylglutathione Lyase