title: Cutaneous leiomyomas lack estrogen and progesterone receptor immunoreactivity.
abstract: Gonadotropin-releasing hormone analog therapy is useful in treating uterine and some extrauterine smooth muscle tumors. These smooth muscle tumors have been demonstrated to have estrogen receptor and progesterone receptor immunoreactivity. The estrogen receptor and progesterone receptor immunoreactivity of smooth muscle tumors of the skin has not been reported. We evaluated 15 examples of cutaneous leiomyomas for estrogen receptor and progesterone receptor with ER-1D5 antibody and PGR-1A6 antibody. None of the 15 cutaneous leiomyomas demonstrated positive staining by this method. The tumorigenesis of cutaneous leiomyomas does not appear to be related to estrogen or progesterone receptor-mediated effects.
authors.affiliation: Department of Pathology, University of Tennessee Medical Center at Knoxville 37920, USA.
authors.forename: K M
authors.initials: KM
authors.lastname: McGinley
authors.forename: S
authors.initials: S
authors.lastname: Bryant
authors.forename: A A
authors.initials: AA
authors.lastname: Kattine
authors.forename: J F
authors.initials: JF
authors.lastname: Fitzgibbon
authors.forename: P B
authors.initials: PB
authors.lastname: Googe
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006651:Histocytochemistry; D006801:Humans; D007889:Leiomyoma / Q000737:chemistry / Q000276:immunology* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011960:Receptors, Estrogen / Q000737:chemistry / Q000276:immunology* / Q000378:metabolism; D011980:Receptors, Progesterone / Q000737:chemistry / Q000276:immunology* / Q000378:metabolism; D012878:Skin Neoplasms / Q000737:chemistry / Q000276:immunology* / Q000473:pathology; D013194:Staining and Labeling
chemical_list: D011960:Receptors, Estrogen; D011980:Receptors, Progesterone