title: Synthesis, crystal structure, and characterization of two metal-quinolone compounds.
abstract: Two novel metal-quinolone compounds have been synthesized and characterized by analytical, spectroscopic, and X-ray diffraction methods. The crystal structure of both, (erxH2) [FeCl4]Cl and (kinoH2)[CuCl4]. H2O, is presented and discussed (erxH2 = doubly protonated form of enrofloxacin, kinoH2 = doubly protonated form of the second quinolone). In both compounds, the hydrogen atom is bonded between the 4-keto oxygen O(1) and carboxylic oxygen O(11), thus preventing the bonding of the metal to this part of the molecule. Antimicrobial activities of metal-quinolone compounds were tested against different microorganisms.
authors.affiliation: Faculty of Chemistry and Chemical Technology, University of Ljubljana, Slovenia.
authors.forename: I
authors.initials: I
authors.lastname: Turel
authors.forename: I
authors.initials: I
authors.lastname: Leban
authors.forename: G
authors.initials: G
authors.lastname: Klintschar
authors.forename: N
authors.initials: N
authors.lastname: Bukovec
authors.forename: S
authors.initials: S
authors.lastname: Zalar
mesh_terms: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D018360:Crystallography, X-Ray; D005658:Fungi / Q000187:drug effects; D008670:Metals; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D015394:Molecular Structure; D015363:Quinolones / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D008670:Metals; D015363:Quinolones