title: Frictional work in double-sided tablet compression.
abstract: The aim of this study was to evaluate the friction during double-sided tablet compression. Dicalcium phosphate dihydrate and lactose were tabletted with a compaction simulator with symmetrical and asymmetrical double-sided sawtooth punch displacement profiles. The estimation of force transmission in a powder column was based on an exponential equation, including the material parameter consisting of both the friction coefficient and Poisson's ratio. This parameter was predetermined from a single-sided compression. A novel equation was derived from a previously presented equation for friction work in single-sided tablet compression. The basic assumption was drawn from the linearly decreasing movement of infinitely thin particle layers, which are produced as the compressing punch surface approaches the other punch. This calculation was also based on the assumption that the equilibrium point, where the particles do not move, is halfway between the punches in the symmetrical profile and at a distance proportional to the amplitudes of the asymmetrical upper and lower sawtooth profiles. The tensile strength of tablets compressed with single-double-sided profiles was identical, and thus the behavior of the materials studied under compression was independent of the compression profiles. The friction work values that were calculated with the proposed expression for double-sided profiles were close to the theoretical values, as estimated by calculations based on compressions with single-sided profiles. In conclusion, the novel mathematical expression opens new possibilities for the evaluation of friction in double-sided compression; for example, in rotary press tabletting.
authors.affiliation: Department of Pharmaceutics, University of Kuopio, Finland.
authors.forename: A
authors.initials: A
authors.lastname: Muñoz-Ruiz
authors.forename: M
authors.initials: M
authors.lastname: Wihervaara
authors.forename: M
authors.initials: M
authors.lastname: Hakkinen
authors.forename: M
authors.initials: M
authors.lastname: Juslin
authors.forename: P
authors.initials: P
authors.lastname: Paronen
mesh_terms: D017276:Friction; D008422:Materials Testing; D008956:Models, Chemical; D013607:Tablets
chemical_list: D013607:Tablets