title: Reduction of telencephalin immunoreactivity in the brain of patients with Alzheimer's disease.
abstract: Telencephalin (TLN) is a cell adhesion molecule expressed in the telencephalon of the mammalian central nervous system. We have investigated immunohistochemically the expression of TLN in human brain tissue from control subjects and patients with Alzheimer's disease (AD). In control brain, neuropil of the gray matter was stained diffusely with the anti-TLN antibody. TLN immunoreactivity was markedly decreased in the brain of AD patients, particularly in the hippocampal formation.
authors.affiliation: Department of Psychiatry, Yokohama City University, School of Medine, Yokohama, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Hino
authors.forename: K
authors.initials: K
authors.lastname: Mori
authors.forename: Y
authors.initials: Y
authors.lastname: Yoshihara
authors.forename: E
authors.initials: E
authors.lastname: Iseki
authors.forename: H
authors.initials: H
authors.lastname: Akiyama
authors.forename: T
authors.initials: T
authors.lastname: Nishimura
authors.forename: K
authors.initials: K
authors.lastname: Ikeda
authors.forename: K
authors.initials: K
authors.lastname: Kosaka
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000378:metabolism*; D001921:Brain / Q000378:metabolism*; D002102:Cadaver; D015815:Cell Adhesion Molecules; D005260:Female; D006624:Hippocampus / Q000378:metabolism; D006801:Humans; D015151:Immunoblotting; D007150:Immunohistochemistry; D008297:Male; D008562:Membrane Glycoproteins / Q000378:metabolism*; D008875:Middle Aged; D009415:Nerve Net / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D010487:Periaqueductal Gray / Q000378:metabolism; D012016:Reference Values; D014018:Tissue Distribution
chemical_list: D015815:Cell Adhesion Molecules; C086747:ICAM5 protein, human; D008562:Membrane Glycoproteins; D009419:Nerve Tissue Proteins