Thrombosis and restenosis after peripheral angioplasty: does acute 111indium-platelet accumulation predict angioplasty outcome?
OBJECTIVE
Use of platelet deposition to predict failure following angioplasty.


METHODS
Prospective study of angioplasty patients in a 9 months surveillance period.


METHODS
Thirty-eight successful angioplasty patients.


METHODS
Autologous 111indium-labelled platelets were re-injected immediately after angioplasty. Gamma camera and probe measures of radioactivity were obtained daily for 2-4 days and compared to a reference site to obtain a radioactivity ratio. Patient follow up was with duplex and arteriography from day 0 to 9 months or at angioplasty failure.


RESULTS
Thirty-one patients remained asymptomatic; two developed acute occlusion and five developed restenosis. Platelet accumulation (increased mean radioactivity ratio) occurred at all angioplasty sites and was significantly higher after acute occlusion (camera: 2.93 and probe: 1.93) compared to asymptomatic patients (camera: 1.25 and probe: 1.15) and restenotic patients (camera: 1.31 and probe: 1.23). Radioactivity ratio was not different in patients who later developed restenosis.


CONCLUSIONS
111Indium platelet radioactivity effectively detected acute angioplasty reocclusions, but was unable to predict subsequent angioplasty restenosis.
Nyamekye
I
I
Vascular Unit, U.C.L. Hospitals NHS Trust, Middlesex Hospital, London, U.K.
Costa
D
D
Raphael
M
M
Bishop
C C
CC
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D017130:Angioplasty / Q000009:adverse effects*; D001157:Arterial Occlusive Diseases / Q000097:blood* / Q000601:surgery*; D005260:Female; D006801:Humans; D007205:Indium Radioisotopes; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation; D011237:Predictive Value of Tests; D011446:Prospective Studies; D011877:Radionuclide Imaging; D012008:Recurrence; D013927:Thrombosis / Q000097:blood / Q000000981:diagnostic imaging / Q000209:etiology*; D016896:Treatment Outcome
D007205:Indium Radioisotopes