title: Human papillomavirus DNA in urine specimens of men with condyloma acuminatum.
abstract: OBJECTIVE
  Because warts are often found in the male urethra, human papillomavirus (HPV) may well be present in urine of patients with urethral condylomata.
  
  
  OBJECTIVE
  To detect HPV DNA in urine specimens of men with condylomata acuminata using polymerase chain reaction.
  
  
  METHODS
  Forty-seven urine specimens and 25 paraffin-embedded tissues of condylomata acuminata were obtained from men. Of the 47 urine specimens, 29 were from patients with urethral condylomata, 3 from patients with penile condylomata only, and 15 from control subjects without condylomata. Both L1 consensus primers and type-specific primers for-HPV 6, 11, 16, 18, and 33 were used.
  
  
  RESULTS
  HPV DNA was detected in 22 of the 29 (76%) urine specimens from patients with urethral condylomata, in none of the 3 urine specimens from patients with penile condylomata, and in none of the 15 controls. Paraffin-embedded tissues of all 25 condylomas were positive for HPV DNA. The HPV types detected in urine were identical to those detected in urethral condylomas.
  
  
  CONCLUSIONS
  HPV DNA is present in urine of patients with urethral condylomata. Urine may be used for noninvasive screening of asymptomatic HPV infections of the male genital tract. Detection of HPV DNA in urine may be useful for monitoring the response to treatment of urethral condylomata.
authors.affiliation: Department of Obstetrics and Gynecology, University of Helsinki, Finland.
authors.forename: A
authors.initials: A
authors.lastname: Iwasawa
authors.forename: E
authors.initials: E
authors.lastname: Hiltunen-Back
authors.forename: T
authors.initials: T
authors.lastname: Reunala
authors.forename: P
authors.initials: P
authors.lastname: Nieminen
authors.forename: J
authors.initials: J
authors.lastname: Paavonen
mesh_terms: D000328:Adult; D003218:Condylomata Acuminata / Q000821:virology*; D004279:DNA, Viral / Q000652:urine*; D006801:Humans; D008297:Male; D008875:Middle Aged; D027383:Papillomaviridae / Q000235:genetics*; D016133:Polymerase Chain Reaction; D014522:Urethral Diseases / Q000821:virology*
chemical_list: D004279:DNA, Viral