title: [Treatment of spasticity with botulinum toxin and muscle afferent block].
abstract: Spasticity is partly caused by disinhibition of spinal stretch reflex activity and blocking of the group Ia afferents may improve its clinical symptoms. Since muscle afferent block has been successfully used for treating dystonia, this method may become useful for treating spasticity as well. We injected diluted lidocaine (0.5%, 50 ml/session) and ethanol (5 ml) into thigh adductors (for leg crossing), medial hamstrings (for medial rotation of the leg), quadriceps femoris (for hyperextension of the knee), tibialis posterior and triceps surae muscles (pes equinovarus deformity), biceps brachii and forearm flexors (for flexion deformities of the upper extremity) in 12 patients with spasticity. Although the duration of action was short (< 1 day) at first, it was gradually prolonged to several weeks by repeating the injection every 3-4 days. The final outcome was comparable to that obtained by botulinum toxin injection in the same group of patients. This method may prove its promise as a means of treating spasticity.
authors.affiliation: Department of Neurology, Kyoto University Hospital.
authors.forename: R
authors.initials: R
authors.lastname: Kaji
authors.forename: T
authors.initials: T
authors.lastname: Mezaki
authors.forename: T
authors.initials: T
authors.lastname: Kubori
authors.forename: N
authors.initials: N
authors.lastname: Murase
authors.forename: J
authors.initials: J
authors.lastname: Kimura
mesh_terms: D000328:Adult; D001905:Botulinum Toxins / Q000627:therapeutic use*; D006801:Humans; D008875:Middle Aged; D009128:Muscle Spasticity / Q000628:therapy*; D009407:Nerve Block / Q000379:methods*
chemical_list: D001905:Botulinum Toxins