Blockade of spontaneous posttraining performance improvement in mice by NMDA antagonists.
We investigated the effects of immediate post-training systemic administration of gamma-L-glutamyl-L-aspartate (gamma-LGLA) and 3-(2-carboxypiperazine-4-yl)-propyl-1-phosphonate (CPP), antagonists at the N-methyl-D-aspartate receptor, in a lever-press task in two inbred strains of mice. When retention performance was tested in control animals 24 h after partial acquisition of the task. BALB/c mice exhibited a spontaneous performance improvement whereas C57BL/6J mice did not gamma-LGLA at doses of 2.5 and 25 mumol/kg and CPP at doses ranging between 0.025 and 2.5 mumol/kg blocked the spontaneous performance improvement found in BALB/c mice but had no apparent effects on the retention performance of C57BL/6J mice. These data suggest that retention impairment induced by CPP and gamma-LGLA in BALB/c mice results from an interference with posttraining memory processes.
Mélan
C
C
Laboratoire de Psychophysiologie, Université Louis Pasteur, URA 1295 CNRS, Strasbourg, France. melan@cict.fr
Eichenlaub
D
D
Ungerer
A
A
Messier
C
C
Destrade
C
C
D000818:Animals; D003216:Conditioning, Operant / Q000187:drug effects; D004151:Dipeptides / Q000494:pharmacology; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology*; D005793:Generalization, Psychological / Q000187:drug effects; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D010879:Piperazines / Q000494:pharmacology; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors*; D012153:Retention, Psychology / Q000187:drug effects* / Q000502:physiology; D013045:Species Specificity
D004151:Dipeptides; D018691:Excitatory Amino Acid Antagonists; D010879:Piperazines; D016194:Receptors, N-Methyl-D-Aspartate; C065286:SDZ EAA 494; C021030:gamma-glutamylaspartic acid