Immunohistochemical analyses of p53 protein expression in breast cancers in Taiwan: a clinicopathologic study.
Immunohistochemical analysis of the p53 protein was performed on paraffin sections of tumor tissue from 210 breast cancer patients. All patients had a follow-up period of more than 5 years. Protein expression of p53 was detected in 64 patients (30.5%). There was significant correlation between p53 protein expression and a high histologic grade (grade II vs grade I/II, 49% vs 23.6%, p = 0.0008) and high mitotic index (> or = 10/10 hpf vs < 10/10 hpf, 42.9% vs 19.6%, p = 0.0004), but not with axillary node status, stromal lymphocytic infiltration, or estrogen receptor or progesterone receptor status. We found that p53 protein expression was not a significant factor in predicting 5-year mortality.
Chu
J S
JS
Department of Pathology, National Taiwan University, Taipei, ROC.
Lee
W J
WJ
Chang
K J
KJ
Hsu
H C
HC
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D005260:Female; D005819:Genetic Markers; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D012189:Retrospective Studies; D016019:Survival Analysis; D013624:Taiwan / Q000453:epidemiology; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*
D005819:Genetic Markers; D016159:Tumor Suppressor Protein p53