Anxiolytic-like effects of metabotropic glutamate antagonist (RS)-alpha-methylserine-O-phosphate in rats.
Using the conflict drinking Vogel test in rats as a model we examined the anxiolytic-like activity of (RS)-alpha-methylserine-O-phosphate (MSOP) and (RS)-alpha-methylserine-O-phosphate-monophenyl ester (MSOPPE), the antagonists of group III and II of mGluR, respectively, after their intrahippocampal administration. The results indicated that MSOP produced a dose dependent anticonflict effect in rats.
Chojnacka-Wójcik
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Institute of Pharmacology, Polish Academy of Sciences, Kraków, Poland.
Tatarczyńska
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Pilc
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D000818:Animals; D014151:Anti-Anxiety Agents / Q000008:administration & dosage / Q000494:pharmacology*; D003220:Conflict, Psychological; D004327:Drinking Behavior / Q000187:drug effects; D006624:Hippocampus; D008297:Male; D008845:Microinjections; D009943:Organophosphorus Compounds / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D018094:Receptors, Metabotropic Glutamate / Q000037:antagonists & inhibitors*; D012694:Serine / Q000031:analogs & derivatives
D014151:Anti-Anxiety Agents; D009943:Organophosphorus Compounds; D018094:Receptors, Metabotropic Glutamate; D012694:Serine