title: Transforming growth factor-beta localization during mouse prostate morphogenesis and in prostatic growth abnormalities.
abstract: Growth and morphogenesis of the prostate involves mesenchymal-epithelial interactions. Transforming growth factor-beta 1 (TGF-beta1) is one growth factor that may play a role in these paracrine interactions. We have localized TGF-beta1 by molecular and immunohistochemical analysis in the developing mouse prostate. Accumulations of TGF-beta1 protein were localized in the mesenchyme surrounding ductules in fetal and neonatal prostate. Previous studies in the mouse prostate reconstitution (MPR) model system have localized accumulations of TGF-beta1 to regions of oncogene-induced abnormalities. In surgically excised adult human prostate tissues, localized accumulations of TGF-beta1 are associated with prostate cancer and benign prostatic hyperplasia (BPH). Intracellular TGF-beta1 was more often associated with stromal cells in BPH and with neoplastic epithelial cells in prostate cancer. The production and accumulation of TGF-beta1 appears to involve interactions between mesenchymal and epithelial cells. Further experimental studies may clarify the relationships between TGF-beta1 and abnormal prostatic growth.
authors.affiliation: Scott Department of Urology, Baylor College of Medicine, Houston, Texas, USA.
authors.forename: T L
authors.initials: TL
authors.lastname: Timme
authors.forename: G
authors.initials: G
authors.lastname: Yang
authors.forename: L D
authors.initials: LD
authors.lastname: Truong
authors.forename: D
authors.initials: D
authors.lastname: Kadmon
authors.forename: S H
authors.initials: SH
authors.lastname: Park
authors.forename: T C
authors.initials: TC
authors.lastname: Thompson
mesh_terms: D000818:Animals; D005314:Embryonic and Fetal Development; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D051379:Mice; D011467:Prostate / Q000196:embryology* / Q000378:metabolism*; D011470:Prostatic Hyperplasia / Q000378:metabolism*; D011471:Prostatic Neoplasms / Q000378:metabolism*; D016212:Transforming Growth Factor beta / Q000378:metabolism*
chemical_list: D016212:Transforming Growth Factor beta