Recombinant interleukin-1 promotes leishmaniasis in susceptible mice.
Interleukin-1 exacerbates leishmanial lesions in Leishmania major-infected BALB/c mice. Indomethacin can modulate the effect of IL-1, so at least part of the IL-1 effect on disease progression is due to the induction of prostaglandin synthesis.
Ajdary
S
S
Immunology Department, Pasteur Institute of Iran, Tehran, Iran.
Hosseini
M H
MH
Alimohammadian
M H
MH
D000818:Animals; D018450:Disease Progression; D007213:Indomethacin / Q000276:immunology; D007375:Interleukin-1 / Q000276:immunology*; D016773:Leishmaniasis, Cutaneous / Q000209:etiology / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D011453:Prostaglandins / Q000096:biosynthesis; D011994:Recombinant Proteins / Q000276:immunology
D007375:Interleukin-1; D011453:Prostaglandins; D011994:Recombinant Proteins; D007213:Indomethacin