Voltage-dependent effect of Al3+ on channel activities in hippocampal neurons.
The effects of Al3+ on Na+ and K+ channel activities in rat and rabbit hippocampal neurons have been examined. Al3+ mediated a pronounced voltage-dependent inhibition of single Na+ channel activities in inside-out patches excised from neuronal membranes. The reduction in channel activity was more substantial under defined conditions, particularly when changing the holding potential from -120 to -80 mV. This voltage-dependent block indicates that Al3+ can mainly inhibit the excitation of neurons with less negative resting potentials. The observed effect may be related to the pathogenetic mechanism of the specific action of Al3+ on defined types of neurons affected in neurodegenerative disorders such as Alzheimer's disease.
Kanazirska
M
M
Department of Medicine, Brigham & Women's Hospital, Boston, Massachusetts, USA.
Vassilev
P P
PP
Birzon
S Y
SY
Vassilev
P M
PM
D000535:Aluminum / Q000494:pharmacology*; D000818:Animals; D006624:Hippocampus / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D015640:Ion Channel Gating; D009474:Neurons / Q000187:drug effects / Q000378:metabolism; D015221:Potassium Channels / Q000187:drug effects* / Q000378:metabolism; D011817:Rabbits; D051381:Rats; D015222:Sodium Channels / Q000187:drug effects* / Q000378:metabolism
D015221:Potassium Channels; D015222:Sodium Channels; D000535:Aluminum