[The alteration of PyNPase activity in breast cancers due to preoperative oral administration of 5'-DFUR].
To estimate the alteration of pyrimidine nucleoside phosphorylase (PyNPase) activity by 5'-DFUR, we determined its activity in the breast tissue of two patient groups. Group A (21 patients) were given 5'-DFUR (mean 9,000 mg) preoperatively, and group B (21 patients) were given no anticancer agents. There were no significant differences between the groups in background factors such as age, clinical stage and pathological features. Comparison of PyNPase activity in both groups among specimens of carcinoma, normal breast glands and lymph nodes revealed that the activity in carcinomas and lymph nodes was significantly higher than in normal breast glands. Comparison of group A with group B showed that group A had lower activity in carcinomas and lymph nodes than in group B, although the difference was not significant. An inter-group comparison of carcinomas was made in detail by subgrouping according to age and pathological features. In group B, PyNPase activity in older patients (> or = 50 y.o) was significantly higher than in younger patients (< 50 y.o), and papillotubular carcinomas had significantly lower activity than solid tubular and scirrhous carcinomas. However, in group A these data could not be determined. These results suggest that PyNPase activity in group A was possibly decreased by 5'-DFUR.
Akao
S
S
Dept. of Surgery, Koshigaya Hospital, Dokkyo University School of Medicine.
Yoshida
M
M
Abe
S
S
Kojima
M
M
Ishikawa
H
H
Soma
R
R
D000284:Administration, Oral; D000328:Adult; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000201:enzymology*; D005260:Female; D005467:Floxuridine / Q000008:administration & dosage*; D006801:Humans; D008875:Middle Aged; D010430:Pentosyltransferases / Q000378:metabolism*; D011300:Preoperative Care; D057845:Pyrimidine Phosphorylases
D000970:Antineoplastic Agents; D005467:Floxuridine; D010430:Pentosyltransferases; D057845:Pyrimidine Phosphorylases; C025034:doxifluridine