A new metabolite of retinol: all-trans-4-oxo-retinol as a receptor activator and differentiation agent.
All-trans-4-oxo-retinol, a metabolite of retinol synthesized in mouse embryonal carcinoma F9 cells, is active in inducing differentiation of these cells. It also functions as a ligand of retinoic acid receptors and a transcriptional activator of reporter genes. These findings may dispel the notion that retinoic acids are the only transactivators of retinoid receptor-dependent pathways. However, there are weaknesses that need to be addressed in order to confirm the relevance of this retinol-mediated signaling pathway.
Ross
S A
SA
Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, MD 20892-4255, USA.
De Luca
L M
LM
D000818:Animals; D001665:Binding Sites; D015394:Molecular Structure; D018168:Receptors, Retinoic Acid / Q000737:chemistry / Q000187:drug effects* / Q000378:metabolism*; D014801:Vitamin A / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology
D018168:Receptors, Retinoic Acid; D014801:Vitamin A; C041819:4-oxoretinol