New azidometalkojates and their biological activity.
Azidometalkojates of the general formula MX2 (M = Cu, Mn, Mg, Zn or Ni and X = 5-hydroxy-2-azidomethyl-4H-pyran-4-one) were prepared and tested for antibacterial, antifungal and cytotoxic effects. The mangan and zinc derivatives are not active against any the tested microorganisms. A weak antibacterial activity was found with the copper derivative. The strongest antifungal effects were shown by the nickel derivative while the highest cytotoxic effect on HeLa cells was manifested by the zinc derivative.
Hudecová
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Department of Biochemistry and Microbiology, Faculty of Chemical Technology, Slovak Technical University, Bratislava, Slovakia.
Jantová
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Melník
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M
Uher
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M
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D002412:Cations; D003300:Copper; D015195:Drug Design; D005658:Fungi / Q000187:drug effects; D006367:HeLa Cells / Q000187:drug effects; D006801:Humans; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D011753:Pyrones / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
C106811:5-hydroxy-2-azidomethyl-4H-pyran-4-one; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D000970:Antineoplastic Agents; D002412:Cations; D011753:Pyrones; C011890:kojic acid; D003300:Copper