title: Do mammography, sonography, and MR mammography have a diagnostic benefit compared with mammography and sonography?
abstract: OBJECTIVE
  The purpose of our study was to assess the added value of MR mammography, mammography, and sonography compared with mammography and sonography in diagnostic evaluation of the breast.
  
  
  METHODS
  We evaluated reports of MR mammography, conventional mammography, and sonography of the breast in 89 patients who had been referred for surgical biopsy. The dynamic MR mammography examinations were obtained on a 1.0-T MR imager using a double-breast coil and a three-dimensional axial fast low-angle shot sequence. Each type of study was interpreted by a different observer. All mammograms and sonograms were available to all observers. Without knowledge of biopsy results, observers classified mammograms and sonograms (which we call the standard method) as well as mammograms, sonograms, and MR mammograms (which we call the combined method). Classifications were on a per-breast basis: no disease; probably a benign or malignant lesion; and most likely a benign or malignant lesion. A classification of no disease or most likely a benign or malignant lesion was considered to represent a high confidence of the observer in the diagnosis.
  
  
  RESULTS
  Of 98 breasts evaluated with the standard method, observer confidence was high for 44% of all malignant lesions versus 86% with the combined method. The highest specificity (92%) was achieved by interpretation of the standard method (combined method, 64%). The highest sensitivity (95%) was achieved by interpretation of the combined method (standard method, 83%). Overall accuracy was 87% for the standard method and 83% for the combined method. In separate analyses of nonpalpable and palpable lesions, the combined method achieved an accuracy of 74% for nonpalpable lesions and 88% for palpable lesions. The standard method achieved an accuracy of 85% for nonpalpable lesions and 88% for palpable lesions.
  
  
  CONCLUSIONS
  MR mammography as an adjunct to mammography and sonography reveals breast cancer with a higher confidence and sensitivity than do mammography and sonography only. The combined method can be recommended if the greatest possible sensitivity or negative predictive value is wanted. However, the combined method is not useful for screening or workup of suspicious lesions because of its lower specificity and accuracy.
authors.affiliation: University of Tübingen, Abteilung Radiologische Diagnostik, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Müller-Schimpfle
authors.forename: P
authors.initials: P
authors.lastname: Stoll
authors.forename: W
authors.initials: W
authors.lastname: Stern
authors.forename: S
authors.initials: S
authors.lastname: Kurz
authors.forename: F
authors.initials: F
authors.lastname: Dammann
authors.forename: C D
authors.initials: CD
authors.lastname: Claussen
mesh_terms: D001940:Breast / Q000473:pathology; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging; D003287:Contrast Media; D004338:Drug Combinations; D005069:Evaluation Studies as Topic; D005260:Female; D019786:Gadolinium DTPA; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008327:Mammography; D008536:Meglumine; D008875:Middle Aged; D009942:Organometallic Compounds; D004369:Pentetic Acid / Q000031:analogs & derivatives; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D016217:Ultrasonography, Mammary
chemical_list: D003287:Contrast Media; D004338:Drug Combinations; D009942:Organometallic Compounds; D008536:Meglumine; D004369:Pentetic Acid; D019786:Gadolinium DTPA