title: Primary intracerebral small-cell osteosarcoma in an adolescent girl: report of a case.
abstract: A young patient surviving four years after treatment for primary intracerebral small-cell osteosarcoma is reported. This 16-year-old girl presented with headaches, visual disturbance, and papilledema and was found to have a large, heavily calcified mass in the left parietal lobe. A gross total resection of the tumor was performed and pathologic analysis revealed a small-cell osteosarcoma. Thoracic computerized tomography (CT) scans and a complete bone scan showed no other lesions. The patient received adjuvant chemotherapy and radiotherapy. She continues to do well with no evidence of metastases or local recurrence 4 years after her initial presentation. The clinical, radiographic, surgical, pathologic, and immunohistochemical features of this case, along with therapeutic interventions and outcome, are presented.
authors.affiliation: Department of Neurosurgery, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA.
authors.forename: E P
authors.initials: EP
authors.lastname: Sipos
authors.forename: R J
authors.initials: RJ
authors.lastname: Tamargo
authors.forename: J I
authors.initials: JI
authors.lastname: Epstein
authors.forename: R B
authors.initials: RB
authors.lastname: North
mesh_terms: D000293:Adolescent; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001761:Bleomycin / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000473:pathology / Q000601:surgery / Q000628:therapy; D017024:Chemotherapy, Adjuvant; D002945:Cisplatin / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000627:therapeutic use; D003609:Dactinomycin / Q000627:therapeutic use; D004317:Doxorubicin / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D012516:Osteosarcoma / Q000473:pathology / Q000601:surgery / Q000628:therapy; D018714:Radiotherapy, Adjuvant
chemical_list: D000970:Antineoplastic Agents; D001761:Bleomycin; D003609:Dactinomycin; D004317:Doxorubicin; D003520:Cyclophosphamide; D002945:Cisplatin