title: Characterization of plasmalogen-selective phospholipase A2 from bovine brain.
abstract: Plasmalogens are hydrolyzed by a plasmalogen-selective phospholipase A2. This enzyme, purified from bovine brain, does not require Ca2+ and is localized in cytosol. It has a molecular mass of 39 kDa and is strongly inhibited by glycosaminoglycans, gangliosides, and sialoglycoproteins. These molecules may be involved in the regulation of its enzymic activity. Plasmalogen-selective phospholipase A2 plays an important role in the release of free fatty acids and platelet-activating factor during trauma.
authors.affiliation: Department of Medical Biochemistry, Ohio State University, Columbus 43210-1218, USA.
authors.forename: H C
authors.initials: HC
authors.lastname: Yang
authors.forename: A A
authors.initials: AA
authors.lastname: Farooqui
authors.forename: L A
authors.initials: LA
authors.lastname: Horrocks
mesh_terms: D000818:Animals; D001921:Brain / Q000201:enzymology; D001923:Brain Chemistry / Q000502:physiology*; D002417:Cattle; D006801:Humans; D010741:Phospholipases A / Q000378:metabolism*; D054467:Phospholipases A2; D010955:Plasmalogens / Q000378:metabolism*; D010972:Platelet Activating Factor / Q000378:metabolism
chemical_list: D010955:Plasmalogens; D010972:Platelet Activating Factor; D010741:Phospholipases A; D054467:Phospholipases A2