Adenosine and neuropathic pain.
Recent studies have reported the possibilities of relieving neuropathic pain by administering adenosine or its analogs. In order to determine if there exists a metabolic anomaly of this nucleoside in patients with neuropathic pain, circulating adenosine levels were compared in three patient groups. The first was composed of individuals suffering from neuropathic pain, the second of patients with nervous system lesions in the absence of pain, and the third was composed of patients suffering from pain resulting from excessive nociception. The adenosine blood levels of these patients were compared to those of a control group. Finally, adenosine in the cerebrospinal fluid (CSF) of some patients was also assayed. The results show that there are reduced levels of blood and CSF adenosine in patients with neuropathic pain. This adenosine deficiency could explain the potential therapeutic effects of administering adenosine or its analogs.
Guieu
R
R
Laboratoire de Biochimie, URA CNRS 1455, Faculté de Médecine Secteur Nord, Marseille, France.
Peragut
J C
JC
Roussel
P
P
Hassani
H
H
Sampieri
F
F
Bechis
G
G
Gola
R
R
Rochat
H
H
D000241:Adenosine / Q000097:blood / Q000134:cerebrospinal fluid / Q000627:therapeutic use*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009437:Neuralgia / Q000097:blood / Q000134:cerebrospinal fluid / Q000188:drug therapy*
D000241:Adenosine