title: Familial hydronephrosis unlinked to the HLA complex.
abstract: Clinical findings, management, and possible linkage of congenital hydronephrosis caused by ureteropelvic junction stenosis to the HLA complex were studied in four families. These families provide evidence of possible autosomal dominant inheritance. HLA class I antigen studies in all four and class II (HLA-DR) in three families were performed. These studies failed to show close linkage to the chromosome 6 markers in two families but there was consistent inheritance in the other two. Although formal linkage calculations are not presented, it is apparent that in some families HLA haplotyping is not useful in predicting prevence of renal obstruction.
authors.affiliation: Department of Medical Genetics and Fetal Medicine, Palacky University, Olomouc, Czech Republic.
authors.forename: A
authors.initials: A
authors.lastname: Santavá
authors.forename: A
authors.initials: A
authors.lastname: Utíkalová
authors.forename: A
authors.initials: A
authors.lastname: Bártová
authors.forename: J
authors.initials: J
authors.lastname: Drabek
authors.forename: J
authors.initials: J
authors.lastname: Santavý
authors.forename: J
authors.initials: J
authors.lastname: Scheinar
mesh_terms: D002648:Child; D002675:Child, Preschool; D008040:Genetic Linkage; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D000949:Histocompatibility Antigens Class II / Q000235:genetics*; D006801:Humans; D006869:Hydronephrosis / Q000151:congenital* / Q000235:genetics; D007223:Infant; D007668:Kidney / Q000002:abnormalities*; D010375:Pedigree; D014517:Ureteral Obstruction / Q000151:congenital* / Q000235:genetics
chemical_list: D015395:Histocompatibility Antigens Class I; D000949:Histocompatibility Antigens Class II