title: Amyloid precursor protein in guinea pigs--complete cDNA sequence and alternative splicing.
abstract: We present the cDNA sequence of the guinea pig amyloid precursor protein comprising the complete coding sequence of 770 amino-acid residues. By alternative splicing of three exons transcripts encoding for 695, 714 and 751 amino acids and all forms previously denoted as L-APP are also generated. Guinea pig amyloid precursor protein was shown to exhibit extensive sequence similarity to its human and murine homologues of approx. 97% at the protein level which implies an evolutionary conserved but yet not fully understood physiological function.
authors.affiliation: Department of Neurochemistry, University of Leipzig, Germany. beckm@server3.medizin.uni-leipzig.de
authors.forename: M
authors.initials: M
authors.lastname: Beck
authors.forename: D
authors.initials: D
authors.lastname: Müller
authors.forename: V
authors.initials: V
authors.lastname: Bigl
mesh_terms: D017398:Alternative Splicing; D000595:Amino Acid Sequence; D016564:Amyloid beta-Protein Precursor / Q000145:classification / Q000235:genetics*; D000818:Animals; D001483:Base Sequence; D018076:DNA, Complementary / Q000235:genetics; D019143:Evolution, Molecular; D006168:Guinea Pigs; D008969:Molecular Sequence Data; D010802:Phylogeny; D012333:RNA, Messenger / Q000235:genetics; D017386:Sequence Homology, Amino Acid
chemical_list: D016564:Amyloid beta-Protein Precursor; D018076:DNA, Complementary; D012333:RNA, Messenger