Circulating interleukin-6 in severe heart failure.
In a group of patients with New York Heart Association class IV heart failure, significant relations between interleukin-6 and tumor necrosis factor-alpha, and between levels of both interleukin-6 and tumor necrosis factor-alpha and plasma levels of norepinephrine were observed. The present study also demonstrates that in patients with heart failure, elevated levels of tumor necrosis factor-alpha and interleukin-6 may be present even without cachexia.
MacGowan
G A
GA
Division of Cardiology, University of Pittsburgh Medical Center, Pennsylvania 15213, USA.
Mann
D L
DL
Kormos
R L
RL
Feldman
A M
AM
Murali
S
S
D000328:Adult; D001794:Blood Pressure; D002100:Cachexia / Q000503:physiopathology; D006325:Heart Atria / Q000503:physiopathology; D006333:Heart Failure / Q000097:blood* / Q000503:physiopathology; D006439:Hemodynamics; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D008875:Middle Aged; D009638:Norepinephrine / Q000097:blood; D012720:Severity of Illness Index; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
D006454:Hemoglobins; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D009638:Norepinephrine