title: Makaluvamine N: a new pyrroloiminoquinone from Zyzzya fuliginosa.
abstract: Makaluvamine N (1), a new pyrroloiminoquinone, was isolated from the Philippine sponge Zyzzya fuliginosa, together with the known compounds makaluvamines A, C, D, E (2-5), and I (6). The structure of 1 was determined by spectroscopic investigation. Makaluvamine N demonstrated an ability to inhibit the catalytic activity of topoisomerase II.
authors.affiliation: Department of Medicinal Chemistry, University of Utah, Salt Lake City 84112, USA.
authors.forename: D A
authors.initials: DA
authors.lastname: Venables
authors.forename: G P
authors.initials: GP
authors.lastname: Concepción
authors.forename: S S
authors.initials: SS
authors.lastname: Matsumoto
authors.forename: L R
authors.initials: LR
authors.lastname: Barrows
authors.forename: C M
authors.initials: CM
authors.lastname: Ireland
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000302:isolation & purification* / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D011161:Porifera / Q000737:chemistry*; D011758:Pyrroles / Q000302:isolation & purification* / Q000494:pharmacology; D015363:Quinolones / Q000302:isolation & purification* / Q000494:pharmacology; D059005:Topoisomerase II Inhibitors; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; D011758:Pyrroles; D015363:Quinolones; D059005:Topoisomerase II Inhibitors; C106021:makaluvamine N