title: Training improves endothelium-dependent vasodilation in resistance vessels of patients with heart failure.
abstract: The effects of physical training on endothelium-dependent vasodilation in skeletal muscle resistance vessels were investigated in patients with heart failure. Forearm blood flows (ml.min-1.100 ml-1) in response to brachial arterial administration of acetylcholine (5 x 10(-5) and 5 x 10(-4) M at 1 ml/min) and nitroglycerin (5 x 10(-6) and 5 x 10(-5) M at 1 ml/min) were determined by strain-gauge venous occlusion plethysmography before and after 8 wk of daily handgrip exercise in 12 patients with chronic heart failure. After 8 wk of daily handgrip exercise, the vasodilatory responses to acetylcholine significantly increased from pretraining values, i.e., 16.6 +/- 2.0 vs. 8.6 +/- 1.3 ml.min-1.100 ml-1 (P < 0.05) and 27.5 +/- 1.5 vs. 14.6 +/- 1.7 ml.min-1.100 ml-1 (P < 0.05), respectively, whereas the vasodilatory responses to nitroglycerin did not change. Handgrip exercise training appears to specifically enhance endothelium-dependent vasodilation in the forearm skeletal muscle circulation of patients with heart failure.
authors.affiliation: Department of Medicine, Albert Einstein College of Medicine, Bronx 10461, USA.
authors.forename: S D
authors.initials: SD
authors.lastname: Katz
authors.forename: J
authors.initials: J
authors.lastname: Yuen
authors.forename: R
authors.initials: R
authors.lastname: Bijou
authors.forename: T H
authors.initials: TH
authors.lastname: LeJemtel
mesh_terms: D000109:Acetylcholine / Q000008:administration & dosage; D001794:Blood Pressure; D001945:Breathing Exercises; D002311:Cardiomyopathy, Dilated / Q000503:physiopathology*; D004730:Endothelium, Vascular / Q000502:physiology*; D005260:Female; D005542:Forearm / Q000098:blood supply; D018737:Hand Strength; D006333:Heart Failure / Q000503:physiopathology*; D006801:Humans; D007261:Infusions, Intra-Arterial; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000098:blood supply / Q000502:physiology; D005996:Nitroglycerin / Q000008:administration & dosage; D012039:Regional Blood Flow; D014664:Vasodilation / Q000502:physiology*; D014665:Vasodilator Agents / Q000008:administration & dosage
chemical_list: D014665:Vasodilator Agents; D005996:Nitroglycerin; D000109:Acetylcholine