No evidence of association between dopamine D3 receptor gene and bipolar affective disorder.
A recent study reported a possible association between allele 1 of the dopamine D3 receptor gene and bipolar affective disorder using the haplotype relative risk approach. In attempt to replicate these findings, we used similar family-based methods, such as the Haplotype-Based Haplotype Relative Risk method and the Transmission Disequilibrium Test, in a sample of 44 bipolar probands from Sardinia with both parents available. Using the Bal I restriction enzyme site polymorphism of Lannfelt et al. (1992), no differences were found between transmitted and non-transmitted alleles and no evidence of linkage disequilibrium was observed.
Piccardi
M P
MP
Department of Neurosciences B.B. Brodie, University of Cagliari, Italy.
Severino
G
G
Bocchetta
A
A
Palmas
M A
MA
Ruiu
S
S
Del Zompo
M
M
D000483:Alleles; D001714:Bipolar Disorder / Q000235:genetics*; D005838:Genotype; D006239:Haplotypes; D006579:Heterozygote; D006801:Humans; D015810:Linkage Disequilibrium; D011110:Polymorphism, Genetic; D017448:Receptors, Dopamine D2 / Q000235:genetics*; D050637:Receptors, Dopamine D3
C493593:DRD3 protein, human; D017448:Receptors, Dopamine D2; D050637:Receptors, Dopamine D3