Cyclosporine A affects serotonergic mechanisms in uremic rats.
The aim of this study was to investigate the mechanism of cyclosporine-induced hypertension in respect to its action on blood serotonergic system. The experiment was carried out on healthy rats and animals with experimental chronic renal failure. Cyclosporine A (CsA) injected into the healthy and uremic rats caused an increase in systolic blood pressure. This effect was completely abolished by ketanserin, an antagonist of 5-HT2 receptors. Concomitantly a rise in blood and platelet serotonin concentration was observed. It is concluded that serotonin may play a role in the development of hypertension caused by CsA. Moreover, ketanserin may serve as a drug for pharmacological protection of CsA-induced rise of blood pressure in uremia.
Krygicz
D
D
Department of Pharmacodynamics, Medical Academy, Białystok, Poland.
Azzadin
A
A
Pawlak
R
R
Małyszko
J S
JS
Pawlak
D
D
Myśliwiec
M
M
Buczko
W
W
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D016572:Cyclosporine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D007650:Ketanserin / Q000494:pharmacology; D007676:Kidney Failure, Chronic / Q000503:physiopathology; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D012701:Serotonin / Q000097:blood / Q000502:physiology*; D014511:Uremia / Q000503:physiopathology*
D012701:Serotonin; D000244:Adenosine Diphosphate; D016572:Cyclosporine; D007650:Ketanserin