T2 relaxation time of bone marrow water and lipid: correlation with serum ferritin in normal individuals.
OBJECTIVE
This study investigated the correlation between the iron content of bone marrow and the transverse relaxation times (T2 values) of bone marrow water and lipid on MRI.


METHODS
The T2 of the water and lipid fractions of bone marrow was selectively measured in the L1-3 vertebral bodies using the chemical shift misregistration effect on MRI. Results were compared to the serum ferritin levels in 27 healthy subjects.


RESULTS
The 1/T2 of the water fraction ws strongly correlated with the serum ferritin, but there was no correlation between the 1/T2 of the lipid fraction and serum ferritin.


CONCLUSIONS
Selective T2 measurement of the water fraction in bone marrow allows precise estimation of the marrow iron content.
Ishijima
H
H
Department of Diagnostic Radiology, Gunma University Hospital, Japan.
Ishizaka
H
H
Aoki
J
J
Inoue
T
T
Endo
K
K
D000328:Adult; D001834:Body Water / Q000378:metabolism*; D001853:Bone Marrow / Q000737:chemistry*; D005260:Female; D005293:Ferritins / Q000097:blood*; D006801:Humans; D007501:Iron / Q000032:analysis; D008055:Lipids / Q000032:analysis*; D008159:Lumbar Vertebrae; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D012016:Reference Values
D008055:Lipids; D005293:Ferritins; D007501:Iron