[Effects of iron deficiency on toxic action of nitrites and endogenous synthesis of N-nitrosamines].
Separate or joint ingestions of water solutions of sodium nitrite and/or N-diethylamine by rats fed iron deficiency diet caused sharp increasing of N-nitrosodiethylamine level in stomach, a decreasing of Hb and increasing of MetHb concentrations in blood of animal. These effects were greater on iron deficient diet than on control diet. The nitrite ingestion caused a decline level of cytochrome P-450 and inhibition of lipid peroxidation in rat liver.
Vlaskina
S G
SG
Zhukova
G F
GF
Alekseeva
I A
IA
Aleshko-Ozhevskiĭ
Iu P
IuP
Khotimchenko
S A
SA
D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000032:analysis; D004048:Diethylamines / Q000008:administration & dosage; D004052:Diethylnitrosamine / Q000032:analysis; D006454:Hemoglobins / Q000032:analysis; D007501:Iron / Q000097:blood / Q000652:urine; D000090463:Iron Deficiencies; D015227:Lipid Peroxidation; D008099:Liver / Q000187:drug effects; D008297:Male; D008706:Methemoglobin / Q000032:analysis; D009573:Nitrites / Q000633:toxicity*; D009602:Nitrosamines; D051381:Rats; D017208:Rats, Wistar; D012977:Sodium Nitrite / Q000008:administration & dosage; D013270:Stomach / Q000737:chemistry
D004048:Diethylamines; D006454:Hemoglobins; D009573:Nitrites; D009602:Nitrosamines; D004052:Diethylnitrosamine; D008706:Methemoglobin; D003577:Cytochrome P-450 Enzyme System; C034281:diethylamine; D007501:Iron; D012977:Sodium Nitrite