Cyclophosphamide in severe steroid-resistant bronchiolitis obliterans organizing pneumonia.
A patient receiving carbamazepine and imipramine presented with severe bronchiolitis obliterans organizing pneumonia (BOOP). He developed progressive respiratory failure in spite of high-dose steroid treatment. Cyclophosphamide was given as adjunctive therapy, and a rapid improvement was seen. The authors suggest that an early therapeutic trial of cyclophosphamide should be considered in patients with BOOP who fail to respond to steroids.
Purcell
I F
IF
Newcastle General Hospital, Newcastle upon Tyne, U.K.
Bourke
S J
SJ
Marshall
S M
SM
D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D018549:Cryptogenic Organizing Pneumonia / Q000188:drug therapy*; D003520:Cyclophosphamide / Q000627:therapeutic use*; D004351:Drug Resistance; D004359:Drug Therapy, Combination; D006801:Humans; D008297:Male; D008875:Middle Aged; D011239:Prednisolone / Q000627:therapeutic use*
D000893:Anti-Inflammatory Agents; D003520:Cyclophosphamide; D011239:Prednisolone