Mapping location of excitation during magnetic stimulation: effects of coil position.
We determined the location of excitation for different positions of a round and butterfly coil during in vitro magnetic stimulation of cut peripheral nerves. We analyzed the conditions under which excitation occurs, either at the termination or at the peak of the field gradients (first spatial derivative of the electric field). These results were then compared to predictions about the location of excitation sites from a theoretical model of magnetic stimulation of finite neuronal structures. Excitation along a straight nerve occurred at terminations when 1) a coil was positioned close to the end of a nerve (at least one diameter length from the end), 2) a nerve ended in a finite terminating impedance much greater than the axial resistance of the nerve, 3) the induced electric field was of sufficient magnitude, pointing in a direction away from the axis of a nerve. Excitation occurred at the negative peak of the field gradients along a nerve when 1) a coil was positioned far away from the ends of a nerve, 2) there were no geometric or volume conductor inhomogeneities around a nerve, and 3) it was of sufficient magnitude. Threshold strengths for excitation at terminations were significantly lower than that for field gradient excitation and comparable to that due to geometric and volume conductor inhomogeneities.
Nagarajan
S S
SS
Applied Neural Control Laboratory, Case Western Reserve University, Cleveland, OH 44106, USA.
Durand
D M
DM
Hsuing-Hsu
K
K
D000818:Animals; D004285:Dogs; D004558:Electric Stimulation; D055590:Electromagnetic Phenomena; D004594:Electrophysiology / Q000295:instrumentation*; D066298:In Vitro Techniques; D008959:Models, Neurological; D010791:Phrenic Nerve / Q000502:physiology; D011892:Rana catesbeiana; D012584:Sciatic Nerve / Q000502:physiology