Serum levels of intercellular adhesion molecule-1 and E-selectin in patients with acute ischaemic stroke.
To investigate the role of circulating intercellular adhesion molecule-1 (ICAM-1) and E-selectin in ischaemic stroke, serum levels of ICAM-1 and E-selectin were measured by ELISA in 51 patients with acute ischaemic stroke within 24 h, and in 25 age-matched healthy controls and 10 young healthy volunteers. Carotid Doppler ultrasonography showed a significant stenosis (> 50%) of the carotid or vertebrobasilar artery in 11 of 51 stroke patients. Serum levels of ICAM-1 [mean (SE)] were higher (P < 0.01) in patients with ischaemic stroke [381 (30) ng/ ml] than in age-matched controls [271 (27) ng/ml] and young controls [246 (6) ng/ml]. There was no significant difference in serum E-selectin levels [mean (SE)] among stroke patients, age-matched and young controls [47 (6), 39 (3), and 41 (3) ng/ ml, respectively; P = NS]. The leucocyte count [mean (SD)] was higher (P < 0.01) in patients with ischaemic stroke [8310 (2800)] than in age-matched controls [6040 (930)]. Serum levels of ICAM-1 and E-selectin did not significantly differ between patients with or without abnormal carotid or vertebrobasilar artery disease. In conclusion, serum ICAM-1 level and leucocyte count were elevated in acute ischaemic stroke within 24 h, while the E-selectin level did not change significantly. This finding suggests that adhesion molecules may play an important role in the post-rolling process of leucocyte-endothelial cell interaction in acute ischaemic stroke.
Shyu
K G
KG
Department of Emergency Medicine, Shin Kong Wu Ho-Su Memorial Hospital, Shih Lin Taipei, Taiwan.
Chang
H
H
Lin
C C
CC
D000368:Aged; D002545:Brain Ischemia / Q000097:blood* / Q000145:classification; D002343:Carotid Artery, Internal / Q000000981:diagnostic imaging; D019040:E-Selectin / Q000097:blood*; D005260:Female; D015600:Glasgow Coma Scale; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D007958:Leukocyte Count; D008297:Male; D011446:Prospective Studies; D012307:Risk Factors; D018616:Ultrasonography, Doppler, Duplex; D014711:Vertebral Artery / Q000000981:diagnostic imaging
D019040:E-Selectin; D018799:Intercellular Adhesion Molecule-1