The effects of cholecystokinin A and B receptor antagonists, devazepide and L 365260, on citalopram-induced decrease of exploratory behaviour in rat.
The present study has been divided into two sets. In the first set, the aim of the experiments was to investigate the dose-response effect of selective serotonin re-uptake inhibitor (SSRI) citalopram on rat exploratory behaviour in the elevated plus-maze. In the second set of experiments, the effect of cholecystokinin (CCK) CCKA and CCKB receptor antagonists, devazepide and L 365260, on citalopram-induced decrease of exploratory behaviour in the elevated plus-maze was studied. Citalopram (5 and 10 mg/kg) decreased the number of open and total arm entries, line crossings on open arms, and percentage of time spent exploring in open arm. Dose 15 mg/kg was without any effect on rat exploratory behaviour. Devazepide (0.01 and 1.0 mg/kg) failed to modify any of the citalopram-induced changes observed. L 365260 (1.0 mg/kg) reversed most of the effects of citalopram: the numbers of open and total arm entries, the number of line crossings, and the percentage of time spent exploring in open arms. L 365260 at dose level 0.01 mg/kg was ineffective. These results support the involvement of the CCKB receptor subtype in SSRI-induced anxiogenic-like effects in rodents.
Matto
V
V
Department of Pharmacology, University of Tartu, Estonia.
Harro
J
J
Allikmets
L
L
D000818:Animals; D001570:Benzodiazepinones / Q000494:pharmacology*; D015283:Citalopram / Q000008:administration & dosage; D020109:Devazepide; D005106:Exploratory Behavior / Q000187:drug effects*; D006727:Hormone Antagonists / Q000494:pharmacology*; D008297:Male; D010671:Phenylurea Compounds; D051381:Rats; D017208:Rats, Wistar; D011949:Receptors, Cholecystokinin / Q000037:antagonists & inhibitors*; D017367:Selective Serotonin Reuptake Inhibitors / Q000008:administration & dosage; D012844:Sincalide / Q000037:antagonists & inhibitors*
D001570:Benzodiazepinones; D015283:Citalopram; D020109:Devazepide; D006727:Hormone Antagonists; D010671:Phenylurea Compounds; D011949:Receptors, Cholecystokinin; D017367:Selective Serotonin Reuptake Inhibitors; D012844:Sincalide; C058121:L 365260