title: Interactions between HIV and hepatitis B virus in homosexual men: effects on the natural history of infection.
abstract: OBJECTIVE
  Hepatitis B virus (HBV) and HIV infections share risk-factors; therefore coinfection is common. Interactions have been reported but controlled studies have been limited. Our objective was to study the effect of HIV infection on the natural history of chronic HBV infection and the reverse effect of the HBV carrier state on HIV infection.
  
  
  METHODS
  Prospective observational cohort study.
  
  
  METHODS
  Open-access outpatient HIV/genitourinary medicine clinic at a Central London hospital.
  
  
  METHODS
  Total of 152 untreated homosexual male HBV carriers and 212 HBV surface antigen-negative controls (41.4 and 70.3% HIV-seropositive, respectively).
  
  
  METHODS
  The rate of loss of serum HBV e antigen (HBeAg) and its reappearance in HIV-infected and HIV-uninfected HBV carriers; serum HBV DNA levels measured by dot-blot hybridization assay), HBV DNA polymerase activity and liver transaminase activities, the progression of HIV infection to symptomatic disease or AIDS in HIV-infected compared with HBV-HIV coinfected patients.
  
  
  RESULTS
  In HIV-infected HBV carriers, serum HBV DNA polymerase activity was higher, alanine aminotransferase was lower and loss of serum HBeAg (mean follow-up, 2.8 years) occurred at a lower rate when compared with HIV-uninfected HBV carriers (estimated relative hazard, 0.39; 95% confidence interval, 0.161-0.942) Concomitant chronic HBV infection had no detectable effect on the rate of progression of HIV disease after correction for lead-time bias.
  
  
  CONCLUSIONS
  This study strengthens the evidence for a significant effect of HIV infection on the natural history of chronic HBV infection, which by prolonging the period of infectivity could have an important impact on the epidemiology of HBV infection in regions, or patient groups, with high HIV seroprevalence. There was no evidence of an important effect of HBV carriage on HIV disease progression.
authors.affiliation: Department of Sexually transmitted Diseases, University College London Medical School, UK.
authors.forename: R J
authors.initials: RJ
authors.lastname: Gilson
authors.forename: A E
authors.initials: AE
authors.lastname: Hawkins
authors.forename: M R
authors.initials: MR
authors.lastname: Beecham
authors.forename: E
authors.initials: E
authors.lastname: Ross
authors.forename: J
authors.initials: J
authors.lastname: Waite
authors.forename: M
authors.initials: M
authors.lastname: Briggs
authors.forename: T
authors.initials: T
authors.lastname: McNally
authors.forename: G E
authors.initials: GE
authors.lastname: Kelly
authors.forename: R S
authors.initials: RS
authors.lastname: Tedder
authors.forename: I V
authors.initials: IV
authors.lastname: Weller
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000453:epidemiology; D000328:Adult; D015331:Cohort Studies; D015658:HIV Infections / Q000150:complications / Q000453:epidemiology*; D015497:HIV-1 / Q000302:isolation & purification*; D006509:Hepatitis B / Q000150:complications / Q000453:epidemiology*; D006515:Hepatitis B virus / Q000302:isolation & purification*; D018451:Homosexuality, Male; D006801:Humans; D008297:Male; D015995:Prevalence; D011446:Prospective Studies; D012307:Risk Factors