Enhancing effect of L-carnitine on some abnormal signs induced by pentylenetetrazol.
L-carnitine (CRT) is known to enhance penetration of some drugs of chemical groups across biological barriers. The aim of the study is to contribute to the problem of influencing the blood-brain-barrier (BBB) under CRT administration. In the case of validity of this presumption, CRT would be able to increase some effects of the central analeptic drug pentylenetetrazol (PTZ). Two different experimental schedules were chosen in respect of PTZ administration. The first one was an administration of a high convulsive dose of 100 mg/kg PTZ, the second one was a repeated administration of low (i.e., subconvulsive) doses of PTZ. CRT increased the total score of abnormal signs induced by a convulsive dose of PTZ. Moreover, CRT was able to accelerate the development of kindling induced by repeated administration of low doses of PTZ.
Herink
J
J
Purkynĕ Military Medical Academy, Hradec Králové.
D000818:Animals; D001812:Blood-Brain Barrier / Q000187:drug effects*; D002331:Carnitine / Q000494:pharmacology*; D003292:Convulsants / Q000008:administration & dosage*; D008297:Male; D010433:Pentylenetetrazole / Q000008:administration & dosage*; D051381:Rats; D017208:Rats, Wistar; D012640:Seizures / Q000139:chemically induced / Q000503:physiopathology*
D003292:Convulsants; D002331:Carnitine; D010433:Pentylenetetrazole