Antigenic diversity thresholds and hazard functions.
In this paper, we answer some points made in a recent paper by N.I. Stilianakis and coworkers on the antigenic diversity threshold model for acquired immune deficiency syndrome pathogenesis. An extended version of the model is then used to compute hazard functions for the human immunodeficiency virus incubation period that are in agreement with empirically observed hazard functions.
May
R M
RM
Department of Zoology, University of Oxford, England.
Stekel
D J
DJ
Nowak
M A
MA
D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology*; D000818:Animals; D000940:Antigenic Variation; D006678:HIV / Q000235:genetics / Q000502:physiology*; D015658:HIV Infections / Q000276:immunology*; D006801:Humans; D008962:Models, Theoretical; D016016:Proportional Hazards Models