Small noncleaved cell lymphoma in an adolescent with the XYY syndrome.
A 19-year-old male was diagnosed with stage III abdominal small noncleaved cell (SNCC) non-Hodgkin lymphoma (NHL). Cytogenetic evaluation of the tumor revealed a complex karyotype which included the t(8;14)(q24;q32), classically associated with this lymphoma histotype, and an extra Y chromosome. After remission was obtained, cytogenetic analysis of bone marrow cells and PHA-stimulated peripheral blood lymphocytes disclosed a normal karyotype except for the persistence of an extra Y chromosome, diagnostic of the XYY syndrome. This is the first reported case of SNCC NHL in an adolescent with the XYY syndrome.
Sandlund
J T
JT
Department of Hematology-Oncology, St. Jude Children's Research Hospital, Memphis, TN 38101, USA.
Raimondi
S C
SC
D000782:Aneuploidy; D002871:Chromosome Banding; D003131:Combined Modality Therapy; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000150:complications* / Q000235:genetics / Q000628:therapy; D008297:Male; D013577:Syndrome; D014997:XYY Karyotype