title: Vitamin D levels in children with cystic fibrosis.
abstract: Serum levels of the important hormone 1,25-dihydroxyvitamin D (1,25-diOHD, calcitriol) have not been extensively evaluated in patients with cystic fibrosis (CF) during the critical period of skeletal growth and development. This study was a cross-sectional, observational assessment of 25-hydroxyvitamin D (25-OHD, calcidiol) and 1,25-diOHD levels in 54 patients with CF. The patients' ages ranged from 4.9 years to 19.5 years (mean, 11.0 years). Levels were correlated with pulmonary function tests, chest x-ray scores, height and weight Z scores, skinfold percentiles, CF genotype, serum chemistries, and use of a vitamin supplement. Levels were compared with those in more than 160 other pediatric patients living in the same region, and all assays were done in the same laboratory. Despite low-normal levels of the 25-OHD precursor, there was a high prevalence of low (18%) and marginal (18%) levels of 1,25-diOHD. None of the various parameters examined correlated with either 25-OHD or 1,25-diOHD levels. The cause, clinical significance, and treatment of low levels of this important hormone in children with CF warrant further study.
authors.affiliation: Department of Orthopaedics, University of North Carolina, Chapel Hill, USA.
authors.forename: R C
authors.initials: RC
authors.lastname: Henderson
authors.forename: G
authors.initials: G
authors.lastname: Lester
mesh_terms: D000293:Adolescent; D000328:Adult; D001827:Body Height; D001835:Body Weight; D002648:Child; D003430:Cross-Sectional Studies; D003550:Cystic Fibrosis / Q000097:blood* / Q000000981:diagnostic imaging / Q000235:genetics / Q000503:physiopathology; D005527:Food, Fortified; D005838:Genotype; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging / Q000503:physiopathology; D011859:Radiography; D012129:Respiratory Function Tests; D012885:Skinfold Thickness; D014807:Vitamin D / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood
chemical_list: D014807:Vitamin D; C097949:1,25-dihydroxyvitamin D