title: Platelet-activating factor (PAF): signalling and adhesion in cell-cell interactions.
abstract: Signalling by PAF is closely linked to adhesive interactions between cells of the inflammatory and vascular systems. It acts as a juxtacrine signal that alters the activity of beta 2 integrins on myeloid leukocytes (Figure 1), and works in concert with P-selectin at the surfaces of endothelial cells (Figure 2 and text). Observations in models of flow and in vivo support the original experiments using cultured endothelium under static conditions that indicated that PAF acts at this vascular interface. P-selectin modifies and integrates signals delivered through the PAF receptor on monocytes (Figure 4). Adhesion via P-selectin and engagement of beta 2 integrins modify signals leading to PAF synthesis (text and Figure 5). The intimate relationship between adhesive events and signalling by PAF may be a critical determinant in its roles in physiologic and pathologic responses.
authors.affiliation: Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, Utah.
authors.forename: G A
authors.initials: GA
authors.lastname: Zimmerman
authors.forename: M R
authors.initials: MR
authors.lastname: Elstad
authors.forename: D E
authors.initials: DE
authors.lastname: Lorant
authors.forename: T M
authors.initials: TM
authors.lastname: Mclntyre
authors.forename: S M
authors.initials: SM
authors.lastname: Prescott
authors.forename: M K
authors.initials: MK
authors.lastname: Topham
authors.forename: A S
authors.initials: AS
authors.lastname: Weyrich
authors.forename: R E
authors.initials: RE
authors.lastname: Whatley
mesh_terms: D000818:Animals; D002448:Cell Adhesion / Q000502:physiology*; D002450:Cell Communication / Q000502:physiology*; D006801:Humans; D007365:Intercellular Junctions / Q000502:physiology; D010972:Platelet Activating Factor / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D010972:Platelet Activating Factor