title: A clinical and histologic examination in humans of the osseous response to implanted natural bone mineral.
abstract: The purpose of this study was to assess the osseous response to implanted particles of an anorganic xenograft bone mineral. Bio-Oss, in six patients with severely resorbed alveolar ridges. The observation period varied between 9 and 44 months; in five of six patients, long-term bone regeneration around the implants was observed. Histologic examination of biopsy material obtained from the graft area showed Bio-Oss particles still present in all patients after the varying observation periods. This raises the question whether Bio-Oss may be regarded as a resorbable material, as previously reported.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Söder Hospital, Stockholm, Sweden.
authors.forename: A
authors.initials: A
authors.lastname: Skoglund
authors.forename: P
authors.initials: P
authors.lastname: Hising
authors.forename: C
authors.initials: C
authors.lastname: Young
mesh_terms: D000368:Aged; D000539:Alveolar Process / Q000473:pathology*; D000540:Alveolar Ridge Augmentation / Q000379:methods*; D001672:Biocompatible Materials / Q000627:therapeutic use*; D001861:Bone Regeneration; D001862:Bone Resorption / Q000601:surgery; D003758:Dental Implantation, Endosseous; D015921:Dental Implants; D005260:Female; D005500:Follow-Up Studies; D015726:Giant Cells / Q000473:pathology; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008336:Mandibular Diseases / Q000601:surgery; D008439:Maxillary Diseases / Q000601:surgery; D008875:Middle Aged; D008903:Minerals / Q000627:therapeutic use*; D010006:Osteoblasts / Q000473:pathology; D019736:Prostheses and Implants; D014183:Transplantation, Heterologous
chemical_list: C077540:Bio-Oss; D001672:Biocompatible Materials; D015921:Dental Implants; D008903:Minerals