title: Treatment of systemic hypertension in cats with amlodipine besylate.
abstract: Amlodipine besylate, a calcium channel blocker, was used to treat (mean +/- standard deviation [SD], 127 +/- 68 days) 12 cats with systemic hypertension. Amlodipine was administered orally at a dosage of 0.625 mg per cat (range, 0.08 to 0.23 mg/kg body weight; mean dose +/- SD, 0.17 +/- 0.04 mg/kg body weight) once daily as a single agent. Average indirect systolic blood pressure measurements in the 12 cases decreased significantly from 198 to 155 mmHg during amlodipine treatment. Significant changes in body weight and serum creatinine and potassium concentrations were not detected. Amlodipine appears to be a safe and effective oral treatment for systemic hypertension in cats when used chronically once daily as a single agent.
authors.affiliation: Department of Medical Sciences, University of Wisconsin-Madison 53706, USA.
authors.forename: R A
authors.initials: RA
authors.lastname: Henik
authors.forename: P S
authors.initials: PS
authors.lastname: Snyder
authors.forename: L M
authors.initials: LM
authors.lastname: Volk
mesh_terms: D000284:Administration, Oral; D017311:Amlodipine / Q000009:adverse effects / Q000592:standards / Q000627:therapeutic use*; D000818:Animals; D000959:Antihypertensive Agents / Q000009:adverse effects / Q000592:standards / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D001835:Body Weight / Q000187:drug effects / Q000502:physiology; D002121:Calcium Channel Blockers / Q000009:adverse effects / Q000592:standards / Q000627:therapeutic use*; D002371:Cat Diseases / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D002415:Cats; D003404:Creatinine / Q000097:blood; D004305:Dose-Response Relationship, Drug; D005260:Female; D006973:Hypertension / Q000188:drug therapy / Q000503:physiopathology / Q000662:veterinary*; D008297:Male; D011188:Potassium / Q000097:blood; D012189:Retrospective Studies
chemical_list: D000959:Antihypertensive Agents; D002121:Calcium Channel Blockers; D017311:Amlodipine; D003404:Creatinine; D011188:Potassium