Decomposition of cisplatin in aqueous solutions containing chlorides by ultrasonic energy and light.
Decomposition of cisplatin in an aqueous 0.15 M chloride solution by diffuse daylight, by monochromatic light, and by ultrasonic energy was studied using a new HPLC method. The relative sensitivity of cisplatin to light copies the curve of the absorption spectrum of cisplatin with maximum at ca. 300 nm; however, any light below 500 nm must be avoided. Sonication also leads to a rapid decomposition of cisplatin. Irradiation by diffuse daylight or sonication of the cisplatin solutions for 5 min leads to ca. 1% amminetrichloroplatinate(II). Using HPLC analysis with diode-array spectrophotometric detection, the main decomposition product was identified as amminetrichloroplatinate(II).
Macka
M
M
Research Institute of Fine Chemicals, Lachema, a. s., Brno, Czech Republic.
Borák
J
J
Seménková
L
L
Kiss
F
F
D000970:Antineoplastic Agents / Q000737:chemistry*; D002712:Chlorides / Q000494:pharmacology*; D002945:Cisplatin / Q000737:chemistry* / Q000528:radiation effects; D004355:Drug Stability; D008027:Light; D012996:Solutions; D014465:Ultrasonics
D000970:Antineoplastic Agents; D002712:Chlorides; D012996:Solutions; D002945:Cisplatin