[Neovir, an interferon inductor, modifies expression of steroid hormone receptors in hormone-dependent tissues and restores sensitivity to tamoxifen in patients with inoperable breast cancer].
A low-molecular inductor of interferon-neovir-was found to increase the expression of estrogen and progesterone receptors in the uterus of ovariectomized rats weighing 210-230 g. It also gave more edge to progesterone receptors and reduced the receptor-reducing effect of tamoxifen in relatively young rats weighing 120-140 g. Sensitivity of breast tumor tissue to tamoxifen was restored and a 60-170 day-long period (observation time) of stabilization of the process ensued in 8 out of 10 patients, following administration of a total dose of 2,000 mg neovir (during one month) to patients with extensive breast tumors resistant to tamoxifen.
Surkov
K G
KG
Tsyrlina
E V
EV
Konstantinova
M M
MM
Bersteĭn
L M
LM
D000166:Acridines / Q000627:therapeutic use*; D000818:Animals; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use*; D019008:Drug Resistance, Neoplasm; D004359:Drug Therapy, Combination; D005260:Female; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects*; D012739:Gonadal Steroid Hormones / Q000096:biosynthesis*; D006801:Humans; D007369:Interferon Inducers / Q000627:therapeutic use*; D008325:Mammary Neoplasms, Experimental / Q000188:drug therapy* / Q000503:physiopathology; D009376:Neoplasms, Hormone-Dependent / Q000188:drug therapy* / Q000503:physiopathology; D051381:Rats; D013629:Tamoxifen / Q000627:therapeutic use*
D000166:Acridines; D018931:Antineoplastic Agents, Hormonal; D012739:Gonadal Steroid Hormones; D007369:Interferon Inducers; D013629:Tamoxifen; C077681:Camedon