Autoantibody profile in African-American patients with lupus nephritis.
Lupus nephritis (LN) is one of the major risk factors for morbidity and overall mortality in systemic lupus erythematosus (SLE). Its pathogenesis is multifactorial, and a number of risk factors, including serological markers, have been identified in recent years, correlating with clinical course and disease severity. Furthermore, a distinctive autoantibody profile has recently been reported in African-American SLE women with LN. The aim of this study was to characterize the autoantibody profile in 222 African-American SLE patients, 94 with LN and 128 without. Only anti-dsDNA achieved statistical significance between the two groups (P < 0.05). Fourteen (14.9%) patients with LN and 15 (11.7%) without it exhibited positive anti-Ro/SS-A, anti-Sm, and anti-nRNP, but without anti-La/SS-B (P > 0.6). We conclude that African-American SLE patients with LN do not exhibit a specific or distinctive autoantibody profile. However, our data confirm the value of anti-dsDNA in SLE patients with LN.
García
C O
CO
Department of Medicine, Louisiana State University Medical Center, New Orleans, USA.
Molina
J F
JF
Gutiérrez-Ureña
S
S
Scopelitis
E
E
Wilson
W A
WA
Gharavi
A E
AE
Espinoza
L R
LR
D000293:Adolescent; D000328:Adult; D001323:Autoantibodies / Q000097:blood / Q000276:immunology*; D044383:Black People; D005260:Female; D006801:Humans; D008181:Lupus Nephritis / Q000276:immunology*; D008297:Male; D001741:Black or African American
D001323:Autoantibodies