title: Prospective randomized study of drainage and resection on non-occlusive segmental portal hypertension in chronic pancreatitis.
abstract: BACKGROUND
  In chronic pancreatitis, compression of the splenic vein and superior mesenteric vein (SMV) by an inflammatory mass may cause segmental portal hypertension. Drainage and resection are the principles of surgery for chronic pancreatitis. This study was devised to evaluate the effect of drainage and resection on venous splanchnic blood flow in patients with non-occlusive segmental portal hypertension.
  
  
  METHODS
  In 14 of 30 patients with chronic pancreatitis predominantly involving the pancreatic head, segmental portal hypertension due to compression of the splenic vein and SMV was detected by means of indirect splenomesentericoportography and Doppler ultrasonography. None of these 14 patients had symptomatic gastric fundic varices. They were allocated randomly to surgical drainage or resection. Median follow-up was 30 (range 12-48) months.
  
  
  RESULTS
  In the resection group, mean(s.d.) splenic vein blood flow increased from 316(46) ml/min before operation to 396(57) ml/min at follow-up (P < 0.01). In the drainage group, preoperative splenic vein blood flow (318(37) ml/min) was not increased after operation (322(37) ml/min). Mean(s.d.) SMV flow increased from 292(42) ml/min before operation to 436(64) ml/min at follow-up (P < 0.01) in the resection group. In the drainage group mean(s.d.) SMV blood flow was 296(32) ml/min before operation and 314(34) ml/min at follow-up. No patient developed fundic gastric varices during follow-up.
  
  
  CONCLUSIONS
  In non-occlusive segmental portal hypertension due to chronic pancreatitis, resection, but not drainage, restores normal venous splanchnic blood flow.
authors.affiliation: Department of General Surgery, University Hospital Eppendorf, University of Hamburg, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Bloechle
authors.forename: C
authors.initials: C
authors.lastname: Busch
authors.forename: C
authors.initials: C
authors.lastname: Tesch
authors.forename: V
authors.initials: V
authors.lastname: Nicolas
authors.forename: K F
authors.initials: KF
authors.lastname: Binmoeller
authors.forename: N
authors.initials: N
authors.lastname: Soehendra
authors.forename: J R
authors.initials: JR
authors.lastname: Izbicki
mesh_terms: D000328:Adult; D001783:Blood Flow Velocity; D001803:Blood Transfusion; D002908:Chronic Disease; D003251:Constriction, Pathologic; D004322:Drainage; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006975:Hypertension, Portal / Q000503:physiopathology / Q000601:surgery*; D008297:Male; D017538:Mesenteric Artery, Superior; D010195:Pancreatitis / Q000503:physiopathology / Q000601:surgery*; D011169:Portal Vein; D011446:Prospective Studies; D013162:Splenic Vein; D018608:Ultrasonography, Doppler