Influence of lidocaine on the hemodynamic parameters in rabbits during general anesthesia.
The aim of the study was to investigate the combined influence of lidocaine and selected general anesthetics on the hemodynamic parameters in rabbits: arterial blood pressure, heart rate, cardiac output, stroke volume, peripheral vascular resistance, renal and hepatic blood flows. Lidocaine given during ketamine general anesthesia decreased markedly renal blood flow. Lidocaine administration intensified the disadvantageous influence of propofol, thiopental and pentobarbital on hepatic blood flow and during ketamine anesthesia lidocaine caused the decrease of hepatic blood flow, not observed after ketamine alone. During thiopental or pentobarbital anesthesia lidocaine may lead to a marked deceleration of heart rate. Lidocaine in thiopental, pentobarbital or propofol anesthesia appeased the hypotensive activities of these anesthetics.
Orszulak-Michalak
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Department of Pharmacodynamics, Medical Academy, Lódź, Poland.
D000768:Anesthesia, General; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D007649:Ketamine / Q000494:pharmacology; D008012:Lidocaine / Q000494:pharmacology*; D008102:Liver Circulation / Q000187:drug effects; D008297:Male; D010424:Pentobarbital / Q000494:pharmacology; D015742:Propofol / Q000494:pharmacology; D011817:Rabbits; D012079:Renal Circulation / Q000187:drug effects; D013318:Stroke Volume / Q000187:drug effects; D013874:Thiopental / Q000494:pharmacology; D014655:Vascular Resistance / Q000187:drug effects
D007649:Ketamine; D008012:Lidocaine; D010424:Pentobarbital; D013874:Thiopental; D015742:Propofol