[Diabetic keratopathy].
A variety of corneal complications which occur in diabetics were briefly reviewed and the importance of the recognition of diabetic keratopathy was emphasized. This particular disease emerges and persists following the undue stress including intraocular surgery or photocoagulation. A varied degree of epithelial disturbance such as superficial punctate keratopathy, persistent epithelial defect, or recurrent corneal erosion can take place based on suppressed cell division, deturgence of barrier function, deterioration of basal cell adhesion, or decreased corneal sensitivity. Corneal endothelium also exhibits abnormalities in cell morphology including coefficient variation or percentages of hexagonal cells so that corneal edema tends to persist postoperatively. The involvement of the polyol pathway has been implicated in the pathogenesis of these disorders.
Ohashi
Y
Y
Department of Ophthalmology, Ehime University School of Medicine, Japan.
D003316:Corneal Diseases / Q000209:etiology* / Q000473:pathology; D048909:Diabetes Complications; D006801:Humans