title: Transcriptional regulation of the Staphylococcus aureus collagen adhesion gene, cna.
abstract: We demonstrate that transcription of the Staphylococcus aureus collagen adhesin gene (cna) is temporally regulated, with expression being highest in exponentially growing cultures and falling to almost undetectable levels as cultures enter the post-exponential-growth phase. The temporal regulation of cna transcription was not affected by mutation of agr. We also demonstrate that the collagen adhesin is expressed by both agr+ and agr-negative S. aureus cells growing in bone.
authors.affiliation: Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock 72205, USA.
authors.forename: A F
authors.initials: AF
authors.lastname: Gillaspy
authors.forename: J M
authors.initials: JM
authors.lastname: Patti
authors.forename: M S
authors.initials: MS
authors.lastname: Smeltzer
mesh_terms: D018829:Adhesins, Bacterial / Q000235:genetics*; D001426:Bacterial Proteins / Q000235:genetics*; D003094:Collagen; D015964:Gene Expression Regulation, Bacterial; D013211:Staphylococcus aureus / Q000235:genetics*; D014158:Transcription, Genetic
chemical_list: D018829:Adhesins, Bacterial; D001426:Bacterial Proteins; C048165:adhesin, Staphylococcus aureus; D003094:Collagen