Synthesis, conformational analysis and antidepressant activity of moclobemide new analogues.
Three new analogues of moclobemide are synthesized. Antidepressant activity of compounds assayed by the Porsolt method reveals that the morpholine ring in moclobemide is one of the key structural parts necessary for antidepressant activity. Superimposition of norepinephrine and gauche forms of serotonin and mociobemide suggest that the phenyl ring, electronegative group attached to the aromatic ring and the amine terminal group may serve as the recognition elements for binding to monoamine oxidase-A (MAO-A).
Ghanbarpour
A
A
Department of Organic Chemistry, Faculty of Pharmacy, Medical Science, University of Tehran, Iran.
Hadizadeh
F
F
Piri
F
F
Rashidi-Ranjbar
P
P
D000928:Antidepressive Agents / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology*; D001549:Benzamides / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology*; D020912:Moclobemide; D008968:Molecular Conformation; D008995:Monoamine Oxidase / Q000378:metabolism; D008996:Monoamine Oxidase Inhibitors / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D000928:Antidepressive Agents; D001549:Benzamides; D008996:Monoamine Oxidase Inhibitors; D008995:Monoamine Oxidase; D020912:Moclobemide