title: Basophilic leukemia in a dog.
abstract: Basophilic leukemia with thrombocytosis was diagnosed in a 4-year-old Shih Tzu. This diagnosis was based on cytochemical staining and cytologic examination of blood and bone marrow smears. Hydroxyurea, an inhibitor of DNA synthesis, at a dose of 50 mg/kg PO bid induced hematologic remission after 7 days of treatment. Adverse effects observed included pruritus, erythema of the ventral abdomen, generalized alopecia, and possibly, diabetes mellitus. The dog remained in remission for 21 months before becoming lethargic, at which time the owners requested euthanasia but did not allow a necropsy.
authors.affiliation: Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville 37901-1071, USA.
authors.forename: E A
authors.initials: EA
authors.lastname: Mears
authors.forename: R E
authors.initials: RE
authors.lastname: Raskin
authors.forename: A M
authors.initials: AM
authors.lastname: Legendre
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001854:Bone Marrow Cells; D004283:Dog Diseases / Q000188:drug therapy / Q000473:pathology*; D004285:Dogs; D005260:Female; D006918:Hydroxyurea / Q000627:therapeutic use; D015471:Leukemia, Basophilic, Acute / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D007962:Leukocytes / Q000187:drug effects; D013922:Thrombocytosis / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*
chemical_list: D000970:Antineoplastic Agents; D006918:Hydroxyurea