title: Intravenous albumin prevents moderate-severe ovarian hyperstimulation in in-vitro fertilization patients: a prospective, randomized and controlled study.
abstract: OBJECTIVE
  To assess the effectiveness of intravenous administration of albumin in prevention of ovarian hyperstimulation syndrome (OHSS) in patients of an in-vitro fertilization program.
  
  
  METHODS
  Prospective randomized study. Patients with hCG day E2 levels are 11010 pmol/l (3000 pg/ml) or more were recruited into two groups. Group A (n = 27) received 10 g 20%, 50 ml human albumin infusion before oocyte pick-up and no medication was administered in Group B (n = 28).
  
  
  RESULTS
  Patients were similar in terms of cycle characteristics. No moderate-severe OHSS developed in Group A whereas one severe OHSS case and four moderate OHSS cases developed in Group B. Statistical analysis revealed a significant (P < 0.05) protection in albumin treated group.
  
  
  CONCLUSIONS
  Human albumin proves effectiveness in prevention of moderate-severe OHSS.
authors.affiliation: Reproductive Endocrinology and IVF Unit, Dr. Zekai Tahir Burak Women's Hospital, Ankara, Turkey.
authors.forename: A Z
authors.initials: AZ
authors.lastname: Isik
authors.forename: O
authors.initials: O
authors.lastname: Gokmen
authors.forename: H B
authors.initials: HB
authors.lastname: Zeyneloglu
authors.forename: S
authors.initials: S
authors.lastname: Kara
authors.forename: G
authors.initials: G
authors.lastname: Keles
authors.forename: B
authors.initials: B
authors.lastname: Gulekli
mesh_terms: D000328:Adult; D000418:Albumins / Q000008:administration & dosage / Q000627:therapeutic use*; D006063:Chorionic Gonadotropin / Q000008:administration & dosage; D004958:Estradiol / Q000097:blood; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007262:Infusions, Intravenous; D016471:Ovarian Hyperstimulation Syndrome / Q000517:prevention & control*; D011247:Pregnancy; D011446:Prospective Studies
chemical_list: D000418:Albumins; D006063:Chorionic Gonadotropin; D004958:Estradiol