Ulcerogenesis: integrating the roles of Helicobacter pylori and acid secretion in duodenal ulcer.
The pathogenesis of duodenal ulcer appears to be multifactorial, involving an imbalance between "aggressive" (e.g., acid and pepsin) and "defensive" (e.g., prostaglandin production, mucus/mucosal barrier, bicarbonate production, blood flow, cell regeneration) factors. Historically, the management of peptic ulcer disease has focused on controlling gastric acid secretion. Recent evidence suggests that Helicobacter pylori infection underlies many of the acid and gastrin abnormalities observed in duodenal ulcer disease and that it plays a pivotal role in the development of gastritis and ulceration.
Peura
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Department of Medicine, University of Virginia School of Medicine, Charlottesville 22908, USA.
D004381:Duodenal Ulcer / Q000209:etiology* / Q000503:physiopathology; D004386:Duodenum / Q000473:pathology; D005753:Gastric Mucosa / Q000378:metabolism*; D005756:Gastritis / Q000150:complications / Q000503:physiopathology; D016481:Helicobacter Infections / Q000150:complications* / Q000503:physiopathology; D016480:Helicobacter pylori; D006801:Humans; D008679:Metaplasia / Q000150:complications / Q000503:physiopathology