title: Prevalence of antimicrobial resistance among 723 outpatient clinical isolates of Moraxella catarrhalis in the United States in 1994 and 1995: results of a 30-center national surveillance study.
abstract: Seven hundred twenty-three isolates of Moraxella catarrhalis obtained from outpatients with a variety of infections in 30 medical centers in the United States between 1 November 1994 and 30 April 1995 were characterized in a central laboratory. The overall rate of beta-lactamase production was 95.3%. When the National Committee for Clinical Laboratory Standards MIC interpretive breakpoints for Haemophilus influenzae were applied, percentages of strains found to be susceptible to selected oral antimicrobial agents were as follows: azithromycin, clarithromycin, and erythromycin, 100%; tetracycline and chloramphenicol, 100%; amoxicillin-clavulanate, 100%; cefixime, 99.3%; cefpodoxime, 99.0%; cefaclor, 99.4%; loracarbef, 99.0%; cefuroxime, 98.5%; cefprozil, 94.3%; and trimethoprim-sulfamethoxazole, 93.5%.
authors.affiliation: Clinical Microbiology Laboratories, University of Massachusetts, Worcester 01655, USA.
authors.forename: G V
authors.initials: GV
authors.lastname: Doern
authors.forename: A B
authors.initials: AB
authors.lastname: Brueggemann
authors.forename: G
authors.initials: G
authors.lastname: Pierce
authors.forename: T
authors.initials: T
authors.lastname: Hogan
authors.forename: H P
authors.initials: HP
authors.lastname: Holley
authors.forename: A
authors.initials: A
authors.lastname: Rauch
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D006801:Humans; D008826:Microbial Sensitivity Tests; D001936:Moraxella catarrhalis / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification; D016870:Neisseriaceae Infections / Q000382:microbiology*; D011159:Population Surveillance; D014481:United States
chemical_list: D000900:Anti-Bacterial Agents