[Toxic habits in relation to cancer of the larynx].
Various modifiable toxic risk factors for cancer of the larynx were evaluated in our geographic area in a retrospective epidemiological study of a sample of 373 patients diagnosed as cancer of the larynx chosen randomly at the La Fe Hospital of Valencia Spain over a 5-year period. A "z" test of the contrast of proportions of the laryngeal cancer series studied and the results of a National Health Survey showed significant differences between the two study populations (p < 0.05). Compared with the National Health Survey, smoking had an odds ratio (OR) of 72.21 (33.10 < OR < 166.31) (p < 0.05, Mantel-Haenszel test). The association between smoking and cancer of the larynx increased with the dose. Alcohol consumption had an OR: 1.52 (1.09 < OR < 2.11) (p < 0.05, Mantel-Haenszel test). Smoking carried a risk of 71.21 and had an etiological fraction of 98.61% (IC 95%: 65.17-100%), thus representing 98.61% of all etiological factors. Control of smoking could have prevented 65.17-100% of cases of cancer of the larynx (243 cases in our series). Alcohol consumption had a risk of 0.52 and etiological fraction of 34.21% (IC 95%: 2.38-100%). Control of alcohol use could have prevented cancer of the larynx in 2.38-100% of cases (9 cases in our series).
Morales Suárez-Varela
M M
MM
Unidad de Investigación Clínico-Epidemiológica, Hospital Dr. Peset. Valencia.
Llopis González
A
A
Moreno Guillem
E
E
Martínez Selva
M I
MI
Vitoria Miñana
I
I
Gisbert
V
V
D000293:Adolescent; D000328:Adult; D000368:Aged; D000428:Alcohol Drinking; D002648:Child; D002675:Child, Preschool; D000431:Ethanol; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D007822:Laryngeal Neoplasms / Q000453:epidemiology / Q000209:etiology* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure / Q000009:adverse effects; D010947:Plants, Toxic; D011897:Random Allocation; D012907:Smoking / Q000009:adverse effects*; D013030:Spain / Q000453:epidemiology; D019966:Substance-Related Disorders / Q000150:complications; D014026:Nicotiana
D000431:Ethanol