A study of tolerance in a concordant xenograft model.
Antibody-mediated rejection appears to constitute the major difference between concordant xenografts and allografts in nonhuman primates. Consistent with its known effect on antibody responses, 5-7 addition of DSG to the conditioning regimen has extended concordant primate xenograft survival for up to 6 months after discontinuation of conventional immunosuppression. In contrast to our observations in recipients of renal allografts, donor-specific skin graft rejection can occur and even in long-term recipients may induce rejection of a previously accepted renal xenograft.
Bartholomew
A M
AM
Transplant Unit, Massachusetts General Hospital, Boston, USA.
Cosimi
A B
AB
Sachs
D H
DH
Bailin
M
M
Boskovic
S
S
Colvin
R
R
Hong
H
H
Johnson
M
M
Kimikawa
M
M
Leguern
A
A
Meehan
S
S
Sablinski
T
T
Wee
S L
SL
Powelson
J
J
D000818:Animals; D000910:Antibodies, Heterophile / Q000097:blood; D000917:Antibody Formation; D000961:Antilymphocyte Serum / Q000627:therapeutic use; D016026:Bone Marrow Transplantation / Q000276:immunology*; D016572:Cyclosporine / Q000494:pharmacology; D006084:Graft Rejection / Q000276:immunology*; D006085:Graft Survival; D006146:Guanidines / Q000494:pharmacology; D007111:Immunity, Cellular; D007074:Immunoglobulin G / Q000097:blood; D007165:Immunosuppression Therapy / Q000379:methods; D007166:Immunosuppressive Agents / Q000494:pharmacology; D016030:Kidney Transplantation / Q000276:immunology*; D008252:Macaca fascicularis; D010215:Papio; D013156:Splenectomy; D013950:Thymus Gland / Q000528:radiation effects; D014183:Transplantation, Heterologous / Q000276:immunology* / Q000473:pathology; D014916:Whole-Body Irradiation
D000910:Antibodies, Heterophile; D000961:Antilymphocyte Serum; D006146:Guanidines; D007074:Immunoglobulin G; D007166:Immunosuppressive Agents; D016572:Cyclosporine; C037258:gusperimus