title: Petrous apex cholesterol granulomas: evolution and management.
abstract: Petrous apex cholesterol granulomas result from obstruction of the normal aeration of the petrous air cells and have traditionally been treated by drainage and stent placement via a transtemporal approach. The immediate results were quite satisfying, but recurrence rates as high as 60% have been reported in some series. The authors present their experience treating 14 patients with petrous apex cholesterol granulomas. An extended middle fossa approach and a petrosal approach were used for eight and two patients, respectively. All underwent complete removal of the granuloma and cyst wall followed by obliteration of the cavity with a pedicled strip of temporalis muscle. No recurrences were seen at a mean follow-up period of 3.8 years. Four patients who did not undergo surgery are being followed clinically and with serial magnetic resonance images. Additionally, the clinical and radiographic findings in this series give new insights into the origin and continued growth of these lesions and confirm what had been described previously only in experimental models. It is concluded that petrous apex cholesterol granulomas feature a continuum of both clinical and radiographic findings and radical removal via an extended middle fossa approach is advocated.
authors.affiliation: Department of Neurosurgery, University of Arkansas for Medical Sciences, Little Rock, USA.
authors.forename: M B
authors.initials: MB
authors.lastname: Eisenberg
authors.forename: G
authors.initials: G
authors.lastname: Haddad
authors.forename: O
authors.initials: O
authors.lastname: Al-Mefty
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000716:Anatomy, Artistic; D001847:Bone Diseases / Q000209:etiology / Q000473:pathology / Q000601:surgery; D002784:Cholesterol / Q000378:metabolism*; D005260:Female; D006099:Granuloma / Q000209:etiology* / Q000473:pathology / Q000601:surgery*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008488:Medical Illustration; D008875:Middle Aged; D010579:Petrous Bone; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D002784:Cholesterol