Gene targeting: things go better with Cre.
New technologies are changing the way in which gene targeting experiments are being designed. It is now becoming possible to analyze gene function in defined tissues at specific times during the life of a mouse.
Jiang
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R
The Jackson Laboratory, Bar Harbor, Maine, 04609, USA.
Gridley
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T
D000818:Animals; D017101:Bacteriophage P1 / Q000201:enzymology / Q000235:genetics; D018014:Gene Transfer Techniques; D017930:Genes, Reporter; D019426:Integrases / Q000096:biosynthesis / Q000378:metabolism*; D051379:Mice; D008822:Mice, Transgenic; D011401:Promoter Regions, Genetic; D016548:Prosencephalon / Q000378:metabolism; D012091:Repetitive Sequences, Nucleic Acid; D014764:Viral Proteins; D001616:beta-Galactosidase / Q000096:biosynthesis
D014764:Viral Proteins; C045073:Cre recombinase; D019426:Integrases; D001616:beta-Galactosidase