Makaluvamine N: a new pyrroloiminoquinone from Zyzzya fuliginosa.
Makaluvamine N (1), a new pyrroloiminoquinone, was isolated from the Philippine sponge Zyzzya fuliginosa, together with the known compounds makaluvamines A, C, D, E (2-5), and I (6). The structure of 1 was determined by spectroscopic investigation. Makaluvamine N demonstrated an ability to inhibit the catalytic activity of topoisomerase II.
Venables
D A
DA
Department of Medicinal Chemistry, University of Utah, Salt Lake City 84112, USA.
Concepción
G P
GP
Matsumoto
S S
SS
Barrows
L R
LR
Ireland
C M
CM
D000818:Animals; D000970:Antineoplastic Agents / Q000302:isolation & purification* / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D011161:Porifera / Q000737:chemistry*; D011758:Pyrroles / Q000302:isolation & purification* / Q000494:pharmacology; D015363:Quinolones / Q000302:isolation & purification* / Q000494:pharmacology; D059005:Topoisomerase II Inhibitors; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; D011758:Pyrroles; D015363:Quinolones; D059005:Topoisomerase II Inhibitors; C106021:makaluvamine N