[Olifen action on mutagenesis in human lymphocytes].
Antihypoxic drug olifen has been studied for effect in 72-hour PHA-stimulated cultures of blood lymphocytes in 15 healthy donors and 35 patients with diseases accompanied by enhanced mutagenesis in lymphocytes (rheumatoid arthritis, systemic lupus erythematosus, hypophyseal adenoma, neoplasms, chronic intoxications). Olifen has no mutagenic effect on mutagenesis in lymphocytes in a wide dose range. In diseases with intensive mutagenesis in lymphocytes olifen exhibits antimutagenic effect without lymphopoiesis.
Mazurov
V I
VI
Military Medical Academy, Saint-Petersburg.
Filev
L V
LV
Sinopal'nikov
D O
DO
Enokhin
S F
SF
Petrova
T N
TN
Medvedev
I V
IV
Volchek
I V
IV
Bykhovets
I V
IV
D000328:Adult; D000975:Antioxidants / Q000008:administration & dosage / Q000627:therapeutic use*; D001782:Blood Donors; D018929:Cell Culture Techniques; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects* / Q000502:physiology; D008875:Middle Aged; D016296:Mutagenesis / Q000187:drug effects*; D010647:Phenyl Ethers / Q000008:administration & dosage / Q000627:therapeutic use*
D000975:Antioxidants; D010647:Phenyl Ethers; C085806:olifen