Comparison of the effects of antidepressant drugs on the level of cAMP in the rat striatum and nucleus accumbens septi.
The effect of acute and repeated administration of three antidepressant drugs with various pharmacological profile: imipramine (IMI), (+)-oxaprotiline (OXA) and citalopram (CIT) on the level of cAMP in the rat striatum (STR) and nucleus accumbens septi (NAS) was studied. Acute and chronic IMI treatment reduced the basal level and the stimulatory effect of forskolin, quinpirole and Gpp(NHp) (guanosine-5'-imidotriphosphate). Forskolin-stimulated level of cAMP was increased in both of examined structures not only following IMI administration but also after acute and repeated administration of CIT and OXA. It is noteworthy that the increase in the sensitivity of adenylate cyclase to forskolin was significantly attenuated by the blockade of D1 receptor with SCH 23390 in the STR, except for CIT. Similar results were obtained in NAS after administration of OXA and CIT. The obtained results indicate that the effect of the antidepressant drugs used on the level of cAMP in the examined brain structures of the rat strongly depends on the pharmacological profile of the given drug.
Rogoz
R
R
Institute of Pharmacology, Polish Academy of Sciences, Kraków, Poland.
Dziedzicka-Wasylewska
M
M
D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D000929:Antidepressive Agents, Tricyclic / Q000494:pharmacology; D015283:Citalopram / Q000494:pharmacology; D005576:Colforsin / Q000494:pharmacology; D000242:Cyclic AMP / Q000378:metabolism*; D018491:Dopamine Agonists / Q000494:pharmacology; D006165:Guanylyl Imidodiphosphate / Q000494:pharmacology; D007099:Imipramine / Q000494:pharmacology; D008297:Male; D008376:Maprotiline / Q000031:analogs & derivatives / Q000494:pharmacology; D017072:Neostriatum / Q000187:drug effects / Q000378:metabolism*; D009714:Nucleus Accumbens / Q000187:drug effects / Q000378:metabolism*; D019257:Quinpirole / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D017447:Receptors, Dopamine D1 / Q000037:antagonists & inhibitors; D017367:Selective Serotonin Reuptake Inhibitors / Q000494:pharmacology
D000928:Antidepressive Agents; D000929:Antidepressive Agents, Tricyclic; D015283:Citalopram; D005576:Colforsin; D000242:Cyclic AMP; D018491:Dopamine Agonists; D006165:Guanylyl Imidodiphosphate; D007099:Imipramine; D008376:Maprotiline; D019257:Quinpirole; D017447:Receptors, Dopamine D1; D017367:Selective Serotonin Reuptake Inhibitors; C027299:hydroxymaprotilin