Influence of hydrocortisone on the analgesic effect, toxicity and metabolism of aspirin in mice.
1. Hydrocortisone (HC; 80 mg/kg body weight, intraperitoneally for 4 days), both alone and in combination with acetylsalicylic acid (ASA; 160 mg/kg body weight, orally, for 4 days), decreased ASA general and specific toxicity via metabolic modulation of drug-metabolizing enzyme systems (intestinal ASA-esterase and hepatic UDP-glucuronyltransferase) and did not change the ASA analgesic effect. 2. ASA alone, given 4 for days, did not change the specific ASA toxicity, but increased its general acute toxicity, which was probably due to alterations in some intestinal and hepatic metabolizing enzyme systems.
Tantcheva
L
L
Institute of Physiology, Bulgarian Academy of Sciences, Sofia, Bulgaria.
Stoytchev
T
T
Rangelova
D
D
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000493:pharmacokinetics / Q000633:toxicity*; D001241:Aspirin / Q000493:pharmacokinetics / Q000633:toxicity*; D001760:Bleeding Time; D001835:Body Weight / Q000187:drug effects; D004347:Drug Interactions; D005753:Gastric Mucosa / Q000187:drug effects / Q000201:enzymology; D006854:Hydrocortisone / Q000494:pharmacology*; D007422:Intestines / Q000187:drug effects / Q000201:enzymology; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008297:Male; D051379:Mice; D010147:Pain Measurement / Q000187:drug effects
D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D001241:Aspirin; D006854:Hydrocortisone