Microbial pathogenesis: genomics and beyond.
The growing number of complete microbial genome sequences provides a powerful tool for studying the biology of microorganisms. In combination with assays for function, genomic-based approaches can facilitate efficient and directed research strategies to elucidate mechanisms of bacterial pathogenicity. As genomic information accrues, the challenge remains to construct a picture of the biology that accurately reflects how individual genes collaborate to create the complex world of microbial specialization.
Strauss
E J
EJ
Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305-5402, USA. estrauss@cmgm.stanford.edu
Falkow
S
S
D000818:Animals; D001419:Bacteria / Q000235:genetics* / Q000472:pathogenicity*; D001424:Bacterial Infections / Q000382:microbiology; D016208:Databases, Factual; D015964:Gene Expression Regulation, Bacterial; D005821:Genetic Techniques; D016680:Genome, Bacterial; D006801:Humans; D017422:Sequence Analysis, DNA; D014774:Virulence / Q000235:genetics*