title: Involvement of the chromosomal region 11q13 in renal oncocytoma: case report and literature review.
abstract: Renal oncocytomas comprise a cytogenetically heterogeneous group of tumors consisting potentially of cytogenetic distinguishable subgroups. Review of the literature revealed loss of chromosome 1 and Y as a possible anomaly for at least one subset oncocytomas. The frequent finding of rearrangements involving chromosome 11 band q13 characterizes another subset of oncocytomas. We report the cytogenetic and pathological features of a renal oncocytoma diagnosed in a 72-year-old woman and found a t(9;11)(p23;q13) as a consistent abnormality. This supports the idea that translocations involving 11q13 define a further subset of oncocytoma.
authors.affiliation: Department of Hematology, Johannes-Gutenberg University, Mainz, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Neuhaus
authors.forename: T
authors.initials: T
authors.lastname: Dijkhuizen
authors.forename: E
authors.initials: E
authors.lastname: van den Berg
authors.forename: S
authors.initials: S
authors.lastname: Störkel
authors.forename: M
authors.initials: M
authors.lastname: Stöckle
authors.forename: B
authors.initials: B
authors.lastname: Mensch
authors.forename: C
authors.initials: C
authors.lastname: Huber
authors.forename: H J
authors.initials: HJ
authors.lastname: Decker
mesh_terms: D018249:Adenoma, Oxyphilic / Q000235:genetics*; D000368:Aged; D002869:Chromosome Aberrations / Q000473:pathology*; D002871:Chromosome Banding; D025063:Chromosome Disorders; D002880:Chromosomes, Human, Pair 11; D002890:Chromosomes, Human, Pair 20; D002891:Chromosomes, Human, Pair 21; D002899:Chromosomes, Human, Pair 9; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000235:genetics*; D014178:Translocation, Genetic