title: Idiopathic thrombocytopenic purpura following allogeneic bone marrow transplantation--treatment with anti-D immunoglobulin.
abstract: A 38-year-old man developed idiopathic thrombocytopenic purpura (ITP) 8 months following allogeneic BMT while being treated for cGVHD with corticosteroids and tacrolimus (FK506). He received two courses of high-dose intravenous immunoglobulin (IvIG) which resulted in transient improvement. A single dose of intravenous anti-D immunoglobulin induced a durable response. Anti-D immunoglobulin is better tolerated, less complicated to administer, and less expensive than a course of IvIG.
authors.affiliation: Brigham and Women's Hospital, Department of Medicine, Boston, MA 02115, USA.
authors.forename: S J
authors.initials: SJ
authors.lastname: Lee
authors.forename: W H
authors.initials: WH
authors.lastname: Churchill
authors.forename: A
authors.initials: A
authors.lastname: Konugres
authors.forename: D G
authors.initials: DG
authors.lastname: Gilliland
authors.forename: J H
authors.initials: JH
authors.lastname: Antin
mesh_terms: D000328:Adult; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000188:drug therapy / Q000209:etiology; D018029:Rho(D) Immune Globulin / Q000008:administration & dosage*; D014184:Transplantation, Homologous
chemical_list: D018029:Rho(D) Immune Globulin