[Humoral immunity and the distribution of HLA antigens in patients with chronic pancreatitis].
132 chronic pancreatitis patients were studied for humoral immunity components and HLA antigens distribution. Antibodies to pancreatic tissue, insulin, o-DNA, d-DNA, n-DNA, ds-RNA were recognized in 44.5, 21.8, 41.8, 29.1, 20.9, 19.1% of chronic pancreatitis patients, respectively. Most pronounced immunological shifts occurred in aggravation of the disease. HLA-antigen typing was indicative of more frequent incidence in chronic pancreatitis patients of antigens HLA A1, B8, B27, Cw1 and less frequent occurrence of antigens A2, Cw4. The results evidence nonuniform etiology and pathogenesis of chronic pancreatitis.
Zhukov
N A
NA
Trukhan
D I
DI
D000328:Adult; D000368:Aged; D000914:Antibodies, Viral / Q000097:blood; D000917:Antibody Formation; D001323:Autoantibodies / Q000097:blood; D002908:Chronic Disease; D004247:DNA / Q000276:immunology; D029822:Enterovirus B, Human / Q000276:immunology; D005260:Female; D006680:HLA Antigens / Q000097:blood*; D006801:Humans; D007330:Insulin Antibodies / Q000097:blood; D008297:Male; D008875:Middle Aged; D010179:Pancreas / Q000276:immunology; D010195:Pancreatitis / Q000208:ethnology / Q000209:etiology / Q000276:immunology*; D012008:Recurrence; D012800:Siberia / Q000453:epidemiology
D000914:Antibodies, Viral; D001323:Autoantibodies; D006680:HLA Antigens; D007330:Insulin Antibodies; D004247:DNA