title: Antimalarial activity of 1,4-epidioxy-bisabola-2,12-diene derivatives.
abstract: 1,4-Epidioxy-bisabola-2,12-diene (3) and aromatic hydroperoxides (4, 5) were prepared by photoxidation of gamma-curcumene (1). Reduction and esterification of 6 and 7 afforded compounds 9 to 10. All compounds were tested in vitro for antimalarial activity. The activity could not be increased significantly, compared with 3. The most active compounds, 3 and 9, did not show in vivo antimalarial activity in mice.
authors.affiliation: Institut für Pharmazeutische Chemie, Universität Bonn.
authors.forename: G
authors.initials: G
authors.lastname: Rücker
authors.forename: E
authors.initials: E
authors.lastname: Breitmaier
authors.forename: D
authors.initials: D
authors.lastname: Manns
authors.forename: W
authors.initials: W
authors.lastname: Maier
authors.forename: A
authors.initials: A
authors.lastname: Marek
authors.forename: B
authors.initials: B
authors.lastname: Heinzmann
authors.forename: K
authors.initials: K
authors.lastname: Heiden
authors.forename: S
authors.initials: S
authors.lastname: Seggewies
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000138:chemical synthesis* / Q000494:pharmacology*; D003474:Curcumin / Q000031:analogs & derivatives / Q000737:chemistry; D005260:Female; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008815:Mice, Inbred Strains; D010777:Photochemistry; D012717:Sesquiterpenes / Q000138:chemical synthesis* / Q000494:pharmacology*
chemical_list: C106120:1,4-epidioxybisabola-2,12-diene; D000962:Antimalarials; D012717:Sesquiterpenes; D003474:Curcumin