Reproductive assessment by continuous breeding: evolving study design and summaries of ninety studies.
The Reproductive Assessment by Continuous Breeding (RACB) design has been used by the National Toxicology Program for approximately 15 years. This article details the evolutions in the thinking behind the design and the end points used in the identification of hazards to reproduction. Means of nominating chemicals are provided, and both early and current designs are described as well as some proposed changes for the future. This introduction is followed by a text and tabular summary of each study performed to date. We hope that this will not only be an explicit presentation of the findings of this testing program to date, but will help stimulate thinking about new ways to detect and measure reproductive toxicity in rodents, and help identify new relationships among the end points that are measured in such studies.
Chapin
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National Institute of Environmental Health Sciences and National Toxicology Program, Research Triangle Park, North Carolina 27709, USA. chapin@niehs.nih.gov
Sloane
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D000178:Acrylamides / Q000633:toxicity; D000822:Animal Husbandry; D000818:Animals; D004785:Environmental Pollutants / Q000633:toxicity*; D004987:Ethers / Q000633:toxicity; D005260:Female; D006801:Humans; D008297:Male; D010795:Phthalic Acids / Q000633:toxicity; D011247:Pregnancy; D051381:Rats; D012098:Reproduction / Q000187:drug effects*; D012107:Research Design; D014116:Toxicology
D000178:Acrylamides; D004785:Environmental Pollutants; D004987:Ethers; D010795:Phthalic Acids