title: Pattern visual evoked potentials represent an early index for the evolution of optic chiasma syndrome of tumoral etiology.
abstract: The use of visual evoked potentials in the detection of optic chiasma syndrome of tumoral etiology has been controversial in the literature. In our study the pattern visual evoked potentials (PVEP) were recorded in 22 healthy free volunteers and in 32 patients with optic chiasma syndrome (OCS) produced by tumors of the hypothalamic-pituitary area, mainly pituitary adenomas with suprasellar extension, proved by CT scan. The PVEP were recorded bilateral after monocular photic stimulation of each atropinized eye, in parallel with a complete ophthalmologic exam consisting in visual field, visual acuity and optic fundus. The main results showed that the latencies P100 recorded bilateral were correlated (p < 0.01) with the types of visual field deficiency, in each hemifield. The changes in P100 latency are more sensitive than the evolution of visual field deficiency by campimetry. The same correlation was observed between the "W" form of P wave with the visual field defect. A significant decrease (p < 0.05) of the amplitude of P100 was observed only if the visual acuity was less than 1/2. It is suggested that the PVEP is a reliable index of diagnosis and evolution for the optic chiasma syndrome aside the usual ophthalmologic exam.
authors.affiliation: Department of Endocrinology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.
authors.forename: C
authors.initials: C
authors.lastname: Badiu
authors.forename: A
authors.initials: A
authors.lastname: Serbănescu
authors.forename: M
authors.initials: M
authors.lastname: Coculescu
mesh_terms: D000293:Adolescent; D000328:Adult; D005074:Evoked Potentials, Visual; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009885:Ophthalmology / Q000379:methods*; D009897:Optic Chiasm / Q000503:physiopathology*; D010911:Pituitary Neoplasms / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology*; D015175:Prolactinoma / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology*; D014786:Vision Disorders / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology