title: Deconstructing the nucleus: global architecture from local interactions.
abstract: Recent advances in fluorescence in situ hybridization and three-dimensional microscopy have revealed a high degree of large-scale order in the nucleus, indicating that the position of each gene within the nucleus is not random. As with any other biological phenomenon, this large-scale organization must ultimately be specified by molecular interactions. Biochemical and molecular investigations have revealed a small set of local molecular-scale interactions that can be used together in a combinatorial fashion to establish a global large-scale nuclear architecture.
authors.affiliation: Department of Biochemistry and Biophysics, University of California, San Francisco, California, 94143, USA.
authors.forename: W F
authors.initials: WF
authors.lastname: Marshall
authors.forename: J C
authors.initials: JC
authors.lastname: Fung
authors.forename: J W
authors.initials: JW
authors.lastname: Sedat
mesh_terms: D000818:Animals; D002467:Cell Nucleus / Q000235:genetics / Q000502:physiology; D002843:Chromatin; D002875:Chromosomes; D005544:Forecasting; D006801:Humans
chemical_list: D002843:Chromatin