Circulating antibody secreting cells and humoral antibody response after parenteral immunization with a meningococcal polysaccharide vaccine.
Antibody-secreting cells (ASC) and serum antibody response were measured in 15 adult volunteers immunized subcutaneously with group A and C meningococcal polysaccharide vaccine. The vaccine induced an IgA-dominated ASC response both to meningococcal group A (Men A) and group C (Men C) polysaccharides suggesting an activation of mucosa-committed B cells. Also the relative increase in serum IgA antibodies was higher than in IgC or IgM antibodies. The results support earlier studies showing that the T-cell independent polysaccharide antigens induce an IgA dominated antibody response and a mucosal response may be induced also by systemic administration.
Nieminen
T
T
National Public Health Institute, Helsinki, Finland.
Kayhty
H
H
Kantele
A
A
D000328:Adult; D000907:Antibodies, Bacterial / Q000097:blood*; D000921:Antibody-Producing Cells / Q000276:immunology*; D001428:Bacterial Vaccines / Q000276:immunology*; D002452:Cell Count; D005260:Female; D006801:Humans; D007114:Immunization; D008297:Male; D022401:Meningococcal Vaccines; D008875:Middle Aged
D000907:Antibodies, Bacterial; D001428:Bacterial Vaccines; D022401:Meningococcal Vaccines