Omental delivery of prostaglandin E1 effectively increases portal venous blood flow in 66%-hepatectomized rats.
Changes in portal venous blood flow (PVF) and systemic arterial blood pressure (SAP) were examined following prostaglandin E1 (PGE) application to the greater omentum and femoral vein in 66%-hepatectomized rats. PVF increased when PGE was administered to the omentum and femoral vein at 7.5 micrograms/kg per min for 2 min. The magnitude of PVF response due to both administrations was dose-dependent, but the duration of the PVF response in the omental application was longer than that in the femoral administration. SAP was unchanged after omental application, while femoral administration reduced SAP concomitant with an increase in PVF. These results suggest that, in this hepatectomized model, the omentum is a better site for PGE administration than the vein, and that omental PGE delivery is also effective for enhancing PVF without inducing any changes in SAP.
Aono
T
T
Department of Surgery, Niigata University School of Medicine, Japan.
Sakaguchi
T
T
Fujita
N
N
Shimizu
T
T
Tsukada
K
K
Hatakeyama
K
K
D000527:Alprostadil / Q000008:administration & dosage*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects* / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D005268:Femoral Vein; D006498:Hepatectomy; D007262:Infusions, Intravenous; D007263:Infusions, Parenteral; D008102:Liver Circulation; D008297:Male; D009852:Omentum / Q000502:physiology; D011169:Portal Vein / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D012039:Regional Blood Flow / Q000187:drug effects
D000527:Alprostadil