A novel monoclonal antibody which reacts with a high molecular weight neuronal cytoplasmic protein and myelin basic protein (MBP) in a patient with macroglobulinemia.
We report on the case of a 70-year-old man with primary macroglobulinemia who showed cranial polyneuropathy and extensive radiculoneuropathy. His serum contained an IgM lambda monoclonal antibody which reacted with both a high molecular weight protein in grey matter and purified myelin basic protein (MBP) on immunoblotting. In an immunohistochemical study, strong immunoreactivity was detected only in the cytoplasm of neurons and weak immunoreactivity was detected in myelin. These findings suggest that this antibody may be related to the pathogenesis of neuronal damage in patients with macroglobulinemia.
Kira
J
J
Department of Neurology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Inuzuka
T
T
Hozumi
I
I
Wada
H
H
Tanaka
K
K
Gondo
H
H
Sato
S
S
Tsuji
S
S
Kobayashi
T
T
D000368:Aged; D000911:Antibodies, Monoclonal; D000918:Antibody Specificity; D015153:Blotting, Western; D003593:Cytoplasm / Q000737:chemistry; D017809:Fatal Outcome; D006801:Humans; D007075:Immunoglobulin M / Q000032:analysis; D007150:Immunohistochemistry; D008297:Male; D004676:Myelin Basic Protein / Q000276:immunology*; D009474:Neurons / Q000737:chemistry / Q000276:immunology*; D008258:Waldenstrom Macroglobulinemia / Q000276:immunology*
D000911:Antibodies, Monoclonal; D007075:Immunoglobulin M; D004676:Myelin Basic Protein