title: An efficient and robust PC program to calculate MR based regional cerebral blood volume maps.
abstract: In addition to morphological and anatomical information, functional information is increasingly used in clinical routine to assess pathological alterations of the brain. In addition to nuclear-medical methods there is a growing interest in using magnetic resonance imaging (MRI) to investigate tissue perfusion of the brain. The method employed is based on the indicator-dilution method after bolus injection of a contrast agent. In this paper we present the implementation of an efficient algorithm to calculate quantitatively the regional cerebral blood volume (rCBV). Computation requires about 1 min on a Macintosh Quadra 660AV. The results are represented as parameter images that allow global overall visual inspection as well as quantitative local evaluation by means of user-defined regions of interest.
authors.affiliation: Department of Diagnostic Radiology, Heinrich-Heine-University, Düsseldorf, Germany. hacklaen@uni-duesseldorf.de
authors.forename: T
authors.initials: T
authors.lastname: Hackländer
authors.forename: J R
authors.initials: JR
authors.lastname: Reichenbach
authors.forename: J
authors.initials: J
authors.lastname: Weule
authors.forename: U
authors.initials: U
authors.lastname: Mödder
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000465:Algorithms; D001479:Basal Ganglia / Q000098:blood supply; D002560:Cerebrovascular Circulation; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008432:Mathematical Computing; D008838:Microcomputers; D008875:Middle Aged; D015203:Reproducibility of Results; D012984:Software; D012985:Software Design; D014584:User-Computer Interface