Trinucleotide repetition and fragile X syndrome.
Insufficiently appreciated as a cause of learning disability and other behavioral problems, fragile X syndrome accounts for almost 10% of inherited mental retardation. Identification of the specific mutation as a dramatic trinucleotide expansion inaugurates an era of accurate diagnosis, and goes far toward explaining the syndrome's inheritance patterns, in which risk varies as the disease descends through a family.
Warren
S T
ST
Emory University School of Medicine, Atlanta, USA.
D000595:Amino Acid Sequence; D005260:Female; D005600:Fragile X Syndrome / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008297:Male; D008967:Molecular Biology; D010375:Pedigree; D010641:Phenotype; D012737:Sex Factors; D018911:Trinucleotide Repeats / Q000235:genetics*