title: Pathogenesis and management of bone lesions in multiple myeloma.
abstract: Osteolytic lesions are among the hallmarks of multiple myeloma (MM). On the other hand, they are rare in B cell malignancies other than MM. Data have shown a close relationship between myeloma cell growth factors and factors involved in the occurrence of bone lesions in MM. Biophosphonates, which are potent inhibitors of bone resorption to control MM-induced hypercalcemia, are of interest due to their ability to slow the progression of MM bone disease.
authors.affiliation: Institute of Biology, Nantes, France.
authors.forename: R
authors.initials: R
authors.lastname: Bataille
authors.forename: S C
authors.initials: SC
authors.lastname: Manolagas
authors.forename: J R
authors.initials: JR
authors.lastname: Berenson
mesh_terms: D001859:Bone Neoplasms / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D006801:Humans; D009101:Multiple Myeloma / Q000473:pathology / Q000503:physiopathology / Q000628:therapy