The genetics of Tourette syndrome.
Tourette syndrome has significant genetic determinants. The mode of transmission, while mildly controversial, generally is thought to be due to a single major locus inherited either as an autosomal dominant trait with reduced penetrance, or as a trait with intermediate inheritance in which some heterozygotes manifest the disorder. These is evidence for a Tourette syndrome spectrum of symptoms that includes obsessive-compulsive disorder. Systematic genome linkage studies of Tourette syndrome are progressing, but to date there are no significant linkage findings, although the search has included many neurologically relevant candidate genes.
Alsobrook
J P
JP
Child Study Center, Yale University School of Medicine, New Haven, Connecticut 06520-7900, USA.
Pauls
D L
DL
D004200:Diseases in Twins; D008040:Genetic Linkage; D006801:Humans; D007173:Imprinting, Psychological; D010641:Phenotype; D005879:Tourette Syndrome / Q000235:genetics*