Autonomic orienting and the allocation of processing resources in schizophrenia patients and putatively at-risk individuals.
The differential allocation of attentional resources to attended and ignored stimuli was examined by measuring skin conductance orienting responses and secondary reaction time in relatively asymptomatic schizophrenia outpatients, demographically matched normal controls, college students putatively at risk for psychosis, and a college student control group. At-risk participants were those with extreme scores on scales for either anhedonia or perceptual aberration-magical ideation (per-mags). Compared to control groups, the patients and per-mags showed secondary reaction time results suggesting a delay in the differential allocation of attentional resources. This deficit was observed particularly in patients and matched controls with few or no skin conductance orienting responses, suggesting that impaired autonomic orienting is related to underlying cognitive-attentional vulnerability factors.
Hazlett
E A
EA
Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029-6574, USA. hazlett@msvax.mssm.edu
Dawson
M E
ME
Filion
D L
DL
Schell
A M
AM
Nuechterlein
K H
KH
D000293:Adolescent; D000328:Adult; D001288:Attention / Q000502:physiology*; D001341:Autonomic Nervous System / Q000503:physiopathology*; D005260:Female; D005712:Galvanic Skin Response / Q000502:physiology; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D011569:Psychiatric Status Rating Scales; D011618:Psychotic Disorders / Q000175:diagnosis / Q000503:physiopathology* / Q000523:psychology; D011930:Reaction Time / Q000502:physiology; D012307:Risk Factors; D012559:Schizophrenia / Q000175:diagnosis / Q000503:physiopathology*; D012565:Schizophrenic Psychology; D012569:Schizotypal Personality Disorder / Q000175:diagnosis / Q000503:physiopathology* / Q000523:psychology; D013334:Students / Q000523:psychology