Growth hormone release of interleukin-1 alpha, interferon-gamma and interleukin-4 from murine splenocytes stimulated with staphylococcal protein A, toxic shock syndrome toxin-1 and streptococcal lysin S.
We investigated changes in the IL-1 alpha, IFN-gamma and IL-4 release from splenocytes in the presence of growth hormone (GH). Splenocytes were stimulated with Protein A (PA), Toxic Shock Syndrome Toxin-1 (TSST-1) and Streptolysin S (SLS). In the presence of GH, splenocytes stimulated with PA, induced a 40% and 50% drop in IL-1 alpha and IFN-gamma release respectively, compared to controls, while no changes were shown in IL-4 release. The release of IFN-gamma by TSST-1-stimulated splenocytes fell by 30%, while no changes were shown in IL-1 alpha and IL-4 release after GH. The release of IL-1 alpha by SLS-stimulated splenocytes increased by 50% in the presence of GH. No changes were shown in IFN-gamma and IL-4 release. The results are discussed in terms of the possibility of an expanding function for these endocrine peptides within the immune system.
Galdiero
M
M
Dipartimento di Patologia, Facolta' di Veterinaria, Universita' degli Studi di Napoli, Federico II Italy.
Vitiello
M
M
Scarfogliero
P
P
Sommese
L
L
D000818:Animals; D001426:Bacterial Proteins / Q000494:pharmacology*; D001427:Bacterial Toxins; D016207:Cytokines / Q000378:metabolism*; D004768:Enterotoxins / Q000494:pharmacology*; D013006:Growth Hormone / Q000494:pharmacology*; D007371:Interferon-gamma / Q000378:metabolism; D007375:Interleukin-1 / Q000378:metabolism*; D015847:Interleukin-4 / Q000378:metabolism; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D013154:Spleen / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D013205:Staphylococcal Protein A / Q000494:pharmacology*; D018089:Superantigens
D001426:Bacterial Proteins; D001427:Bacterial Toxins; D016207:Cytokines; D004768:Enterotoxins; D007375:Interleukin-1; D013205:Staphylococcal Protein A; D018089:Superantigens; C030107:enterotoxin F, Staphylococcal; D015847:Interleukin-4; D007371:Interferon-gamma; D013006:Growth Hormone