title: Schizophrenia and chromosome 6p.
abstract: Several studies have recently reported genetic linkage between markers located on the short arm of chromosome 6 and schizophrenia. Valid conclusions, however, are difficult to formulate because chromosomal markers that yielded positive results span a relatively large region of chromosome 6, and studies did not necessarily obtain consistent results with regard to the particular loci tested. Here, we report a meta-analysis of the results of linkage studies of schizophrenia that used chromosome 6p markers. After conducting a systematic search, nine different studies were selected for the analysis using defined criteria. Pooled P values were obtained for all common markers investigated and provided additional support for a major susceptibility locus for schizophrenia in this region. In addition, two markers located 2 cM apart, D6S274 and D6S285, provided the most significant results. These findings may help narrow the chromosomal region in the search for a major gene implicated in schizophrenia.
authors.affiliation: Department of Neurology and Neuroscience, McGill University, Montreal, Canada.
authors.forename: G
authors.initials: G
authors.lastname: Turecki
authors.forename: G A
authors.initials: GA
authors.lastname: Rouleau
authors.forename: R
authors.initials: R
authors.lastname: Joober
authors.forename: J
authors.initials: J
authors.lastname: Mari
authors.forename: K
authors.initials: K
authors.lastname: Morgan
mesh_terms: D002896:Chromosomes, Human, Pair 6; D008040:Genetic Linkage; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D006801:Humans; D012559:Schizophrenia / Q000235:genetics*
chemical_list: D005819:Genetic Markers