Randomised double blind study of hypotonic oral rehydration solution in diarrhoea.
A hypotonic (osmolality 224 mmol/l, sodium 60 mmol/l) oral rehydration solution (ORS) was compared with an isotonic high glucose ORS (osmolality 304 mmol/l, sodium 60 mmol/l) in children with acute diarrhoea in a randomised double blind study. The stool output and hence the mean consumption of ORS for maintenance hydration was less (p = 0.036) in patients receiving hypotonic (69 ml/kg) than isotonic (97 ml/kg) ORS. Hypotonic ORS was more effective in patients with rotavirus positive than with rotavirus negative diarrhoea.
Rautanen
T
T
Department of Paediatrics, Jorvi Hospital, Espoo, Finland.
Kurki
S
S
Vesikari
T
T
D000208:Acute Disease; D000257:Adenoviridae Infections / Q000150:complications / Q000628:therapy; D003967:Diarrhea / Q000628:therapy* / Q000821:virology; D004311:Double-Blind Method; D005260:Female; D005440:Fluid Therapy; D006801:Humans; D007038:Hypotonic Solutions; D007223:Infant; D008297:Male; D009994:Osmolar Concentration; D015532:Rehydration Solutions / Q000737:chemistry / Q000627:therapeutic use*; D012400:Rotavirus Infections / Q000150:complications / Q000628:therapy; D012964:Sodium / Q000627:therapeutic use*
D007038:Hypotonic Solutions; D015532:Rehydration Solutions; D012964:Sodium