[Immunogenetic mechanisms in autoimmune processes: disorders of immune regulatory mechanisms, genetic determination of autoimmunity, effector mechanisms of autoimmune processes and their therapy].
Autoimmune disease represent a great social and medical problem. 5 to 7% of population suffer from these chronic debilitating disorders. Our knowledge about the immune system and the genetic determination of its components and processes has considerably increased in the fast few years. The purpose of the two articles on autoimmunity published in the previous and this issue is to offer a reader a topical status of the development in this field. Autoantigens, their presentation to T lymphocytes and superantigens were discussed in the first article. The breakdown of regulatory mechanisms of immunity, the genetic basis of autoimmunity, the effector mechanisms responsible for tissue damages and their therapy are reviewed in the presented article. (Tab. 4, Fig. 1.).
Buc
M
M
Imunologický ústav Lekarskej fakulty Univerzity Komenského v Bratislave, Slovakia. buc@fmed.uniba.sk
D001327:Autoimmune Diseases / Q000276:immunology* / Q000628:therapy; D015551:Autoimmunity / Q000235:genetics / Q000276:immunology*; D006801:Humans