[Acute pharmacological test of clonidine in essential tremor].
Thirty-seven patients with essential tremor were given intramuscular clonidine injections of 0.3 mg. Physical examination and statistical analysis showed that response was highly positive (t = 13.47; p < 0.0001) 60 min after administration. The absence of peripheral alpha-adrenergic receptors for tremor suggest that the drug acts centrally, consistent with the theory that essential tremor originates in a central oscillating pacemaker.
Serrano Dueñas
M
M
Servicio de Neurología, Instituto Oftalmológico Santa Lucía, Quito, Ecuador.
D000316:Adrenergic alpha-Agonists / Q000008:administration & dosage / Q000627:therapeutic use; D000328:Adult; D000368:Aged; D003000:Clonidine / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D008297:Male; D008875:Middle Aged; D014202:Tremor / Q000188:drug therapy*
D000316:Adrenergic alpha-Agonists; D003000:Clonidine