The development of nonpeptide angiotensin II receptor antagonists: a success story.
The modulation of the renin-angiotensin system continues to be an important target in drug design. The development of nonpeptide angiotensin II receptor antagonists offers a new tool in treatment of hypertension. Starting from benzimidazole lead structures detailed structure-activity analyses, molecular modeling methods, and dedicated syntheses led to the development of potent, orally active antihypertensive drugs.
Höltje
H D
HD
Institute for Pharmaceutical Chemistry, Heinrich-Heine-University Düsseldorf, Germany.
Jessen
G
G
Höltje
M
M
D000804:Angiotensin II / Q000378:metabolism*; D057911:Angiotensin Receptor Antagonists; D000818:Animals; D006801:Humans; D012084:Renin-Angiotensin System / Q000187:drug effects / Q000502:physiology
D057911:Angiotensin Receptor Antagonists; D000804:Angiotensin II