Presence of S-100 beta in cholinergic neurones of the rat hindbrain.
The double staining of S-100 beta and choline acetyltransferase (ChAT) revealed that S-100 beta immunoreactivity was localized in most, but not in all, cholinergic neurones in the somatomotor nuclei of the cranial nerves and in the ambiguus nucleus. S-100 beta was present in almost all cholinergic neurones in the brain stem reticular, red, vestibular (excluding medial), mesencephalic trigeminal and cerebellar nuclei. However, S-100 beta immunoreactivity was lacking in cholinergic neurones in the parabrachial complex, the dorsal motor nucleus of the vagal nerve and most sensory nuclei. No S-100 beta-positive neurones lacked ChAT immunoreactivity. Taken together with the fact that the vulnerability of motoneurones to axotomy is markedly reduced in the first 3 postnatal weeks, during which period neuronal S-100 beta appears and increases, a possible effect of S-100 beta on the survival of cholinergic motoneurones may be suggested.
Yang
Q
Q
Department of Anatomy and Cell Biology, University of Göteborg, Sweden.
Hamberger
A
A
Khatibi
N
N
Stigbrand
T
T
Haglid
K G
KG
D000818:Animals; D002795:Choline O-Acetyltransferase / Q000378:metabolism; D019084:Fluorescent Antibody Technique, Indirect; D007124:Immunoenzyme Techniques; D007150:Immunohistochemistry; D008297:Male; D009474:Neurons / Q000378:metabolism*; D010275:Parasympathetic Nervous System / Q000166:cytology / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012249:Rhombencephalon / Q000166:cytology / Q000378:metabolism*; D009418:S100 Proteins / Q000378:metabolism*
D009418:S100 Proteins; D002795:Choline O-Acetyltransferase