[Acute theophylline intoxication as differential diagnosis of pneumothorax in an asthma patient].
The ambulance was called to a known asthmatic patient. On arrival, the team found a massively dyspnoeic, diaphoretic, non-cyanotic and somnolent patient. His medication consisted of oral theophylline (unknown dosage), fenoterol (metered-dose inhaler), as well as 8 mg oral prednisolone. On the day of emergency, the patient had been treated by two physicians who applied two doses of i.v. theophylline and one dose of s.c. terbutaline because of bronchoconstriction (dosage not documented). The patient's pulse was frequent with 200 beats/min, the blood pressure not measurable. Careful i.v. titration of metoprolol was started to decrease the patient's heart rate and increase diastolic filling and stroke volume. However, the patient showed a progressive circulatory collapse. Following diagnostic thoracocentesis to rule out a left-side pneumothorax, the patient required intubation and mechanical ventilation because of increasing cardiovascular instability. A tension pneumothorax developed immediately after mechanical ventilation and required rapid treatment with a chest tube. Nevertheless, CPR and intravenous infusion of catecholamines were necessary before the patient was referred to a medical intensive care unit where he died the same day in cardiogenic shock. Clinical signs and symptoms associated with an elevated theophylline plasma level make theophylline toxicity the probable causative event for the patient's emergency condition of acute theophylline intoxication.
Schaarschmidt
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Abteilung für Anästhesiologie, Universitäts-Krankenhaus Eppendorf.
Standl
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D000284:Administration, Oral; D001249:Asthma / Q000175:diagnosis / Q000188:drug therapy*; D001993:Bronchodilator Agents / Q000493:pharmacokinetics / Q000506:poisoning*; D003937:Diagnosis, Differential; D004305:Dose-Response Relationship, Drug; D062787:Drug Overdose / Q000097:blood / Q000175:diagnosis*; D017809:Fatal Outcome; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007262:Infusions, Intravenous; D007279:Injections, Subcutaneous; D008297:Male; D008508:Medication Errors; D008875:Middle Aged; D011030:Pneumothorax / Q000097:blood / Q000139:chemically induced* / Q000175:diagnosis; D012770:Shock, Cardiogenic / Q000139:chemically induced; D013726:Terbutaline / Q000493:pharmacokinetics / Q000506:poisoning*; D013806:Theophylline / Q000493:pharmacokinetics / Q000506:poisoning*
D001993:Bronchodilator Agents; D013806:Theophylline; D013726:Terbutaline