title: Gastric emptying following pylorus-preserving Whipple and duodenum-preserving pancreatic head resection in patients with chronic pancreatitis.
abstract: BACKGROUND
  After pylorus-preserving Whipple (PPW), delayed gastric emptying (DGE) is reported in up to 50% of these patients. We analyzed gastric emptying and hormonal adaptation of cholecystokinin (CCK), pancreatic polypeptide (PP), and gastrin following two surgical procedures for chronic pancreatitis (CP): the PPW and the duodenum-preserving pancreatic head resection (DPPHR).
  
  
  METHODS
  Ten patients underwent DPPHR and 10 underwent PPW for CP. Preoperatively and 10 days and 6 months postoperatively, gastric emptying (paracetamol absorption test) and CCK, gastrin, and PP were measured using a test meal stimulation.
  
  
  RESULTS
  The area under the serum paracetamol time curve for 0 to 120 minutes (AUC) showed no preoperative difference. Ten days postoperatively, the AUC was significantly reduced (P <0.05) after PPW but not after DPPHR. Six months postoperatively, AUC was comparable with the preoperative findings in DPPHR and PPW. The integrated 180-minute PP release was significantly reduced 10 days and 6 months postoperatively in both groups. The integrated 180-minute CCK release was decreased 10 days after PPW, but failed to be significant (P = 0.053). Gastrin levels were postoperatively unchanged.
  
  
  CONCLUSIONS
  Following DPPHR we found no delay in gastric emptying. In contrast, DGE occurs early after PPW. Our data may help explain the slower recovery in PPW patients with regard to weight gain and relief from pain, which may be due to the functional alteration of gastric emptying and motility after this type of surgery.
authors.affiliation: Department of General Surgery, University of Ulm, Germany.
authors.forename: M W
authors.initials: MW
authors.lastname: Müller
authors.forename: H
authors.initials: H
authors.lastname: Friess
authors.forename: H G
authors.initials: HG
authors.lastname: Beger
authors.forename: J
authors.initials: J
authors.lastname: Kleeff
authors.forename: B
authors.initials: B
authors.lastname: Lauterburg
authors.forename: B
authors.initials: B
authors.lastname: Glasbrenner
authors.forename: R L
authors.initials: RL
authors.lastname: Riepl
authors.forename: M W
authors.initials: MW
authors.lastname: Büchler
mesh_terms: D000082:Acetaminophen / Q000097:blood; D000328:Adult; D002766:Cholecystokinin / Q000097:blood; D002908:Chronic Disease; D005260:Female; D005746:Gastric Emptying; D005755:Gastrins / Q000097:blood; D006801:Humans; D008297:Male; D008875:Middle Aged; D010191:Pancreatic Polypeptide / Q000097:blood; D016577:Pancreaticoduodenectomy / Q000379:methods*; D010195:Pancreatitis / Q000097:blood / Q000503:physiopathology* / Q000601:surgery*; D011183:Postoperative Complications / Q000097:blood / Q000503:physiopathology*
chemical_list: D005755:Gastrins; D000082:Acetaminophen; D010191:Pancreatic Polypeptide; D002766:Cholecystokinin