title: Brain energy metabolism, cognitive function and down-regulated oxidative phosphorylation in Alzheimer disease.
abstract: Reduced brain glucose utilization in early stages of Alzheimer disease, as measured with in vivo positron emission tomography, reflects potentially reversible down-regulation of gene expression for oxidative phosphorylation within neuronal mitochondria. Such down-regulation may occur when neuronal energy demand is first reduced by synaptic dysfunction or loss.
authors.affiliation: Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA. sir@helix.nih.gov
authors.forename: S I
authors.initials: SI
authors.lastname: Rapoport
authors.forename: K
authors.initials: K
authors.lastname: Hatanpää
authors.forename: D R
authors.initials: DR
authors.lastname: Brady
authors.forename: K
authors.initials: K
authors.lastname: Chandrasekaran
mesh_terms: D000544:Alzheimer Disease / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000503:physiopathology; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000503:physiopathology; D003071:Cognition; D004734:Energy Metabolism; D006801:Humans; D010085:Oxidative Phosphorylation; D014055:Tomography, Emission-Computed