Photoactivation of the nitric oxide donor SIN-1.
This study investigates whether nitric oxide (NO) release from linsidomine (SIN-1), the active metabolite of the antianginal drug molsidomine, is light sensitive. A 9-h irradiation with polychromatic visible light increased the formation of nitrite (NO index metabolite) from SIN-1 (1 mM) by 61% as compared to control samples incubated in the dark. Under the same conditions (9-h irradiation) the concentration of oxygen decreased to 2% of control. However, oxygen consumption was substantially reduced when light was excluded (35% recovery after 9 h). These results show that irradiation with visible light markedly enhances the oxygen-dependent NO release from SIN-1. Thus, sydnonimines appear to be suitable model compounds for the development of photoactivatable NO donors.
Ullrich
T
T
Department of Pharmacology and Toxicology, School of Pharmacy, Martin Luther University, Halle (Saale), Germany.
Oberle
S
S
Abate
A
A
Schröder
H
H
D008981:Molsidomine / Q000031:analogs & derivatives* / Q000737:chemistry; D009569:Nitric Oxide / Q000138:chemical synthesis*; D009599:Nitroprusside / Q000737:chemistry; D010777:Photochemistry
D009599:Nitroprusside; D009569:Nitric Oxide; C002385:linsidomine; D008981:Molsidomine