Theodore R. Woodward Award. Age-related decline in growth hormone secretion: clinical significance and potential reversibility.
Acute and chronic stimulation of GH secretion occurred after administration of MK-677 in normal elderly subjects and IGF-I was increased during four weeks of treatment. The activation of the GH/ IGF-I axis was achieved without adversely affecting ACTH, cortisol or prolactin secretion.
Thorner
M O
MO
Department of Medicine, University of Virginia Health Sciences Center, Charlottesville 22908, USA. MOT@virginia.edu
D000273:Adipose Tissue / Q000033:anatomy & histology / Q000187:drug effects; D000293:Adolescent; D000328:Adult; D000368:Aged; D000375:Aging / Q000097:blood / Q000473:pathology / Q000502:physiology*; D001363:Awards and Prizes; D002648:Child; D015510:Clinical Medicine; D005260:Female; D019382:Human Growth Hormone / Q000172:deficiency / Q000378:metabolism*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007211:Indoles / Q000494:pharmacology; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009842:Oligopeptides / Q000494:pharmacology; D011388:Prolactin / Q000097:blood; D012955:Societies, Medical; D013141:Spiro Compounds / Q000494:pharmacology; D014481:United States
D007211:Indoles; D009842:Oligopeptides; D013141:Spiro Compounds; D019382:Human Growth Hormone; C041048:growth hormone releasing hexapeptide; D007334:Insulin-Like Growth Factor I; D011388:Prolactin; C094817:ibutamoren mesylate; D006854:Hydrocortisone