Regional eruptive neurofibromas.
A 71-year-old woman presented with multiple, flesh-colored, papular lesions on the left dorsal side of the hand which had erupted 5 years earlier. No cafè-au-lait spots, freckles, or Lisch nodules were detected. Family history did not disclose neurofibromas or abnormal pigmentation. Two biopsy specimens of the lesions showed circumscribed, non-encapsulated neurofibromas. Segmental neurofibromatosis is characterized by the unilateral, segmental appearance of neurofibromas and/or cafè-au-lait spots in the absence of genetic transmission. The authors discuss the significance of localized multiple cutaneous neurofibromas in the absence of family history and suggest the possibility of a cutaneous hamartoma.
Betti
R
R
Clinica Dermatologica IV, Università degli Studi di Milano, Ospedale S. Paolo, Italy.
Cerri
A
A
Gualandri
L
L
Moneghini
L
L
Crosti
C
C
D000368:Aged; D005260:Female; D006225:Hand; D006801:Humans; D017253:Neurofibromatoses / Q000473:pathology*; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000473:pathology*