The role of cell migration and microchimerism in the induction of tolerance after solid organ transplantation.
A new hypothesis has been proposed which states that microchimerism is the basis for the clinical tolerance seen in long-term survivors of solid organ transplants. Efforts to enhance microchimerism include simultaneous infusion of bone marrow of donor origin and transplantation of a solid organ. Studies are in progress to verify the phenomenon of microchimerism and its role in clinical tolerance.
Jindal
R M
RM
Department of Surgery, Indiana University School of Medicine, Indianapolis 46202, USA.
Sahota
A
A
D016026:Bone Marrow Transplantation; D002465:Cell Movement; D002678:Chimera; D006801:Humans; D007108:Immune Tolerance; D016377:Organ Transplantation; D011184:Postoperative Period; D014181:Transplantation Immunology