Effects of lovastatin on the fatty acid desaturation in a human lung mucoepidermoid carcinoma grown in nude mice.
The effect of lovastatin, a hypocholesterolemic drug, on tumor growth and desaturase activity was studied in a human lung mucoepidermoid carcinoma (HLMC) grown in nude mice. After administration of a diet supplemented with 25 mg% (w/w) lovastatin for 30 days the growth of HLMC was not inhibited. Liver and tumor phospholipid/cholesterol ratio was increased in lovastatin group but serum cholesterol was unaffected. Treatment with lovastatin increased delta 5 and delta 9 desaturation in tumor microsomes, whereas delta 6 desaturation did not change in tumors of treated mice. The changes were not reflected in the fatty acid composition of total tumor lipids.
de Bravo
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MG
Instituto de Investigaciones Bioquimicas de La Plata (INIBIOLP), Facultad de Ciencias Medicas, Argentina.
Schinella
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Polo
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Tournier
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D000818:Animals; D000924:Anticholesteremic Agents / Q000008:administration & dosage*; D018277:Carcinoma, Mucoepidermoid / Q000378:metabolism*; D004032:Diet; D005227:Fatty Acids / Q000378:metabolism*; D006801:Humans; D008148:Lovastatin / Q000008:administration & dosage*; D008175:Lung Neoplasms / Q000378:metabolism*; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000378:metabolism*
D000924:Anticholesteremic Agents; D005227:Fatty Acids; D008148:Lovastatin