Hepatoblastoma in an adult associated with c-met proto-oncogene imbalance.
A rare case of hepatoblastoma in a 61-year-old Japanese housewife is described. This liver tumor mainly consisted of two tissue components: embryonal hepatocytes and primitive mesenchymal tissue. Fetal hepatocytes with alpha-fetoprotein production, gland formation, cartilage and osteoid were also found in a small portion. Molecular analysis by slot blot method revealed increased copy numbers of c-met and K-sam proto-oncogenes and cyclin D1 genes. These findings suggest that alterations of these oncogenes might play a role in the development of adult hepatoblastoma.
Kuniyasu
H
H
First Department of Pathology, Hiroshima University School of Medicine, Japan.
Yasui
W
W
Shimamoto
F
F
Fujii
K
K
Nakahara
M
M
Asahara
T
T
Dohi
K
K
Tahara
E
E
D019938:Cyclin D1; D016213:Cyclins / Q000378:metabolism; D005260:Female; D018197:Hepatoblastoma / Q000209:etiology / Q000378:metabolism* / Q000473:pathology; D017228:Hepatocyte Growth Factor / Q000378:metabolism; D006801:Humans; D015151:Immunoblotting; D007150:Immunohistochemistry; D008113:Liver Neoplasms / Q000209:etiology / Q000378:metabolism* / Q000473:pathology; D008875:Middle Aged; D015513:Oncogene Proteins / Q000378:metabolism; D000090063:Proto-Oncogene Mas; D019859:Proto-Oncogene Proteins c-met; D020794:Receptor Protein-Tyrosine Kinases / Q000378:metabolism*; D051497:Receptor, Fibroblast Growth Factor, Type 2; D017468:Receptors, Fibroblast Growth Factor / Q000378:metabolism
D016213:Cyclins; C000715470:MAS1 protein, human; D015513:Oncogene Proteins; D000090063:Proto-Oncogene Mas; D017468:Receptors, Fibroblast Growth Factor; D019938:Cyclin D1; D017228:Hepatocyte Growth Factor; C496353:FGFR2 protein, human; D019859:Proto-Oncogene Proteins c-met; D020794:Receptor Protein-Tyrosine Kinases; D051497:Receptor, Fibroblast Growth Factor, Type 2