title: [Clinico-morphologic reconsideration of anaplastic lymphoma. Retrospective study of 60 patients with aggressive clinical course and multiple recurrences].
abstract: OBJECTIVE
  To identify anaplastic large cell lymphoma Ki-1+ (ALCL-Ki-1+) among a group of patients with aggressive Hodgkin's disease (HD) and to know the biological behaviour of the neoplasia (ALCL-Ki-1+).
  
  
  METHODS
  Biopsies and clinical data of sixty patients with previous morphological diagnosis of HD lymphocytic depletion (LD), syncytial variant of nodular esclerosis (NE-II) and other subtypes of HD with aggressive clinical features were reviewed. A morphological, immunohistochemical (IHQ), proliferative and flow cytometric (FCM) studies were performed in lymph node biopsies.
  
  
  RESULTS
  Morphological study and IHQ identify three groups: 15 patients (25%) lymphocytic predominance (LP) HD, 36 (60%) ALCL-Ki-1+ and 9 (15%) of non-Hodgkin's lymphoma (NHL) and unclassifiable cases. Nine cases of LP show anaplastic and variable immunophenotype being the rest of B-cell nature. 75% of LP patients showed long survival and frequent second neoplasias (47%). ALCL-Ki-1+ group had good initial response to therapy (84%) and multiple relapses, 67% showed CD15 positive marker (the so-called ALCL-HD related).
  
  
  CONCLUSIONS
  A retrospective study of a selected group of patients previously diagnosed of aggressive HD showed different pathological subtypes: LP, LP with anaplastic areas, ALCL-Ki-1+ Hr (Hodgkin's related) and ALCL-Ki-1+ (classical type), all of them were CD30+, which could represent different stages of the same neoplasia.
authors.affiliation: Departamento de Oncología, Fudación Jiménez Díaz, Universidad Autónoma, Madrid.
authors.forename: A G
authors.initials: AG
authors.lastname: Ageitos
authors.forename: C
authors.initials: C
authors.lastname: Rivas
authors.forename: F
authors.initials: F
authors.lastname: Lobo
authors.forename: G
authors.initials: G
authors.lastname: Obeso
authors.forename: B
authors.initials: B
authors.lastname: Marcos
authors.forename: I
authors.initials: I
authors.lastname: Gonzalo
authors.forename: G
authors.initials: G
authors.lastname: Echezarreta
authors.forename: R G
authors.initials: RG
authors.lastname: Delgado
authors.forename: H
authors.initials: H
authors.lastname: Oliva
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D005260:Female; D006801:Humans; D017728:Lymphoma, Large-Cell, Anaplastic / Q000401:mortality / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology / Q000473:pathology*; D012189:Retrospective Studies; D015996:Survival Rate