title: Ultrastructural changes in primary endings of deaf white cats.
abstract: Changes in brain structure occur as a consequence of altered experience. During maturation of the auditory nervous system, sensory deprivation is known to cause cell loss, abnormal axonal projections, and synaptic alterations. These animal data may be relevant to clinical observations that cochlear implants provide superior benefit for individuals who become deaf postlingually compared with those who become deaf prelingually. That is, implantation appears most efficacious if it occurs after functional connections are established but before deprivation-induced changes in the central auditory system. After this period, synaptic reorganization may underlie the diminished effectiveness of cochlear implants.
authors.affiliation: Center for Hearing Sciences, Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
authors.forename: D M
authors.initials: DM
authors.lastname: Huchton
authors.forename: T
authors.initials: T
authors.lastname: Pongstaporn
authors.forename: J K
authors.initials: JK
authors.lastname: Niparko
authors.forename: D K
authors.initials: DK
authors.lastname: Ryugo
mesh_terms: D000818:Animals; D002415:Cats; D017626:Cochlear Nucleus / Q000648:ultrastructure*; D003638:Deafness / Q000235:genetics / Q000473:pathology* / Q000503:physiopathology; D016057:Evoked Potentials, Auditory, Brain Stem; D005260:Female; D008297:Male; D008928:Mitochondria / Q000648:ultrastructure; D009411:Nerve Endings; D013569:Synapses / Q000648:ultrastructure*