title: Hypocholesterolemic efficacy of garlic-smelling flower Adenocalymma alliaceum Miers. in experimental rats.
abstract: Dried flower of A. alliaceum when fed at 2% level in diet for 6 weeks to experimental rats rendered hypercholesterolemic by cholesterol feeding, exhibited blood cholesterol lowering effect. Cholesterol lowering efficacy of these garlic smelling flowers was similar to garlic oil fed at 0.002% level. Animals fed A. alliaceum flowers excreted higher amounts of neutral and acidic sterols in faeces similar to onion or asafoetida fed (at 2% dietary level) rats. A. alliaceum significantly lowered the absorption of dietary cholesterol from intestine like other sulfur containing spices, viz. garlic oil, onion and asafoetida. It is inferred from this study that limitation in intestinal cholesterol absorption is responsible for cholesterol lowering effect of this flower in hypercholesterolemic animals.
authors.affiliation: Department of Biochemistry and Nutrition, Central Food Technological Research Institute, Mysore, India.
authors.forename: M R
authors.initials: MR
authors.lastname: Srinivasan
authors.forename: K
authors.initials: K
authors.lastname: Srinivasan
mesh_terms: D000818:Animals; D000924:Anticholesteremic Agents / Q000494:pharmacology*; D005260:Female; D005737:Garlic; D009812:Odorants; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000924:Anticholesteremic Agents; D010936:Plant Extracts