The cytotoxic interaction of inorganic trace elements with EDTA and cisplatin in sensitive and resistant human ovarian cancer cells.
Cisplatin (CDDP)-sensitive and -resistant human ovarian cells were studied in vitro with the objective of enhancing CDDP cytotoxicity by the addition of a metal and the chelate ethylenediaminetetraacetic acid (EDTA), to the CDDP. Chelateable elements, such as bismuth, calcium, cadmium, copper, iron, magnesium, selenium, vanadium, and zinc, when added to CDDP and in the presence of EDTA increased the cytotoxicity of the CDDP as compared to CDDP treatment alone.
Maier
R H
RH
Department of Surgery, School of Medicine, East Carolina University, Greenville, North Carolina 27858-4354, USA.
Purser
S M
SM
Nicholson
D L
DL
Pories
W J
WJ
D000970:Antineoplastic Agents / Q000494:pharmacology*; D002118:Calcium / Q000494:pharmacology; D016923:Cell Death; D002614:Chelating Agents / Q000494:pharmacology; D002945:Cisplatin / Q000494:pharmacology*; D019008:Drug Resistance, Neoplasm; D004492:Edetic Acid / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008274:Magnesium / Q000494:pharmacology; D010051:Ovarian Neoplasms / Q000473:pathology*; D014131:Trace Elements / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D002614:Chelating Agents; D014131:Trace Elements; D004492:Edetic Acid; D008274:Magnesium; D002945:Cisplatin; D002118:Calcium