Foodborne outbreaks of human toxoplasmosis.
Two outbreaks of acute toxoplasmosis involving 8 adult patients in Korea were linked to eating uncooked pork. In the first outbreak, 3 patients developed unilateral chorioretinitis within 3 months of eating a meal consisting of raw spleen and liver of a wild pig. In the second outbreak, 5 of 11 soldiers who ate a meal consisting of raw liver of a domestic pig developed lymphadenopathy. All 8 patients had high levels of IgG Toxoplasma gondii antibodies (> or = 1:1024) in the Sabin-Feldman dye test, modified agglutination test incorporating mercaptoethanol, and latex agglutination test. T. gondii IgM antibodies persisted in these patients for several months. Most patients had a favorable response to anti-T. gondii chemotherapy with pyrimethamine and sulfanomides.
Choi
W Y
WY
Department of Parasitology, School of Medicine, Catholic University of Korea, Seoul.
Nam
H W
HW
Kwak
N H
NH
Huh
W
W
Kim
Y R
YR
Kang
M W
MW
Cho
S Y
SY
Dubey
J P
JP
D000328:Adult; D000372:Agglutination Tests; D000818:Animals; D000890:Anti-Infective Agents / Q000627:therapeutic use; D000913:Antibodies, Protozoan / Q000097:blood; D004196:Disease Outbreaks; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007723:Korea / Q000453:epidemiology; D008297:Male; D008460:Meat / Q000469:parasitology*; D008875:Middle Aged; D011739:Pyrimethamine / Q000627:therapeutic use; D013449:Sulfonamides / Q000627:therapeutic use; D013552:Swine; D014123:Toxoplasmosis / Q000188:drug therapy / Q000453:epidemiology* / Q000276:immunology / Q000635:transmission; D014126:Toxoplasmosis, Ocular / Q000188:drug therapy / Q000635:transmission
D000890:Anti-Infective Agents; D000913:Antibodies, Protozoan; D007074:Immunoglobulin G; D013449:Sulfonamides; D011739:Pyrimethamine