Hormone replacement therapy: benefit and safety issues.
Based on evidence that hormone replacement therapy is cardioprotective, enthusiasm for universal hormone replacement therapy in postmenopausal women has grown Estrogens lower LDL, raise HDL, dilate arteries and reduce LDL oxidation potential. However, the benefits of hormone replacement therapy must be weighed against potential risks of thrombotic events, endometrial cancer and breast cancer. Data from randomized, placebo-controlled trials are not yet available to verify whether benefits exceed risk. Tabulating the evidence discussed below, most postmenopausal women will benefit from hormone replacement therapy.
Denke
M A
MA
University of Texas Southwestern Medical Center, Dallas, USA.
D015914:Estrogen Replacement Therapy / Q000009:adverse effects; D005260:Female; D006801:Humans; D006973:Hypertension / Q000209:etiology; D015228:Hypertriglyceridemia / Q000209:etiology; D008075:Lipoproteins, HDL / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood; D009376:Neoplasms, Hormone-Dependent / Q000473:pathology; D010024:Osteoporosis / Q000517:prevention & control; D017698:Postmenopause; D013927:Thrombosis / Q000209:etiology
D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL