title: Prognostic significance of non-gastric malignancy after treatment of early gastric cancer.
abstract: BACKGROUND
  The recurrence rate of early gastric cancer is low and so second malignancies developing after treatment of this cancer have potential prognostic significance.
  
  
  METHODS
  Some 633 patients with early gastric cancer were studied. The median observation time was 123 months. To examine the characteristics of patients with early gastric cancer and subsequent malignancy, two groups of patients, those with and those without non-gastric malignancy, were compared using univariate analysis with respect to various clinicopathological factors. To determine which parameters were independently significant, computer-based multivariate discriminant function analysis was applied. To estimate the prognostic significance of non-gastric malignancy, death rates from these diseases in patients treated for early gastric cancer were compared with the mortality rates attributable to the same diseases in the general population of Japan.
  
  
  RESULTS
  The frequency of other malignancies, 9.6 per cent (61 of 633), was significantly higher than those gastric cancer recurrence rate of 2.4 per cent (15 of 633). After treatment for early gastric cancer patients with subsequent non-gastric malignancy had a significantly poorer outcome than those free from other cancers. Lung cancers were the major neoplasms occurring after the treatment of early gastric cancer. Univariate and multivariate analysis revealed male sex to be an independent risk factor for the subsequent development of non-gastric malignancy. Comparison of mortality rates revealed that men with early gastric cancer have a higher risk of death from non-gastric malignancy than the general male population.
  
  
  CONCLUSIONS
  These results suggest that systemic surveillance is particularly important for male patients after the treatment of early gastric cancer.
authors.affiliation: First Department of Surgery, Faculty of Medicine, University of Tokyo, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Seto
authors.forename: H
authors.initials: H
authors.lastname: Nagawa
authors.forename: T
authors.initials: T
authors.lastname: Muto
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016609:Neoplasms, Second Primary / Q000401:mortality*; D011379:Prognosis; D012737:Sex Factors; D013274:Stomach Neoplasms / Q000601:surgery*; D015996:Survival Rate; D013997:Time Factors