title: [Etiologic distribution of children with congenital defects].
abstract: BACKGROUND
  Although it has been generally admitted that we know the cause of congenital malformations in about 40% of the cases, these data are based on very few studies.
  
  
  METHODS
  Here we present the distribution of 22,784 malformed infants in our country by type of cause of their defects.
  
  
  RESULTS
  Our results show a great impact of chromosomal alterations in causing congenital anomalies. On the other hand, performing the chromosomal study will enable the diagnosis of genetic entities, as well as environmental ones that are clinically similar to the clinical patterns produced by chromosomal abnormalities.
  
  
  CONCLUSIONS
  We can recognize the cause of congenital defects in a proportion higher than the 40% which is generally accepted. Nowadays, there is no reason that justifies not performing a chromosomal study with high resolution band techniques in infants with congenital defects.
authors.affiliation: ECEMC Dpto. de Farmacología, Facultad de Medicina, Universidad Complutense de Madrid.
authors.forename: M L
authors.initials: ML
authors.lastname: Martínez Frías
authors.forename: E
authors.initials: E
authors.lastname: Rodríguez Pinilla
authors.forename: E
authors.initials: E
authors.lastname: Bermejo Sánchez
authors.forename: M
authors.initials: M
authors.lastname: Urioste Azcorra
authors.forename: A
authors.initials: A
authors.lastname: Villa Milla
authors.forename: I
authors.initials: I
authors.lastname: Lorda Sánchez
authors.forename: J L
authors.initials: JL
authors.lastname: Frías
mesh_terms: D000013:Congenital Abnormalities / Q000453:epidemiology* / Q000209:etiology*; D006801:Humans; D007231:Infant, Newborn