title: Temporal production of streptococcal erythrogenic toxin B (streptococcal cysteine proteinase) in response to nutrient depletion.
abstract: The effects of various growth conditions on the production of streptococcal erythrogenic toxin B (streptococcal pyrogenic exotoxin B [SPE B]) by Streptococcus pyogenes were analyzed. SPE B was detected in broth culture supernatant fluid only during the stationary phase of growth when glucose and other potential carbon sources were depleted from the medium. Additionally, SPE B production was inhibited when the concentration of glucose in the medium was maintained. These results suggest that SPE B is secreted under conditions of starvation and may be involved in nutrient acquisition.
authors.affiliation: Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City 73190, USA. mchaussee@nih.gov
authors.forename: M S
authors.initials: MS
authors.lastname: Chaussee
authors.forename: E R
authors.initials: ER
authors.lastname: Phillips
authors.forename: J J
authors.initials: JJ
authors.lastname: Ferretti
mesh_terms: D002244:Carbon / Q000378:metabolism; D003470:Culture Media / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism; D016196:S Phase; D013297:Streptococcus pyogenes / Q000254:growth & development / Q000378:metabolism*; D013301:Streptolysins / Q000032:analysis / Q000096:biosynthesis*
chemical_list: D003470:Culture Media; D013301:Streptolysins; D002244:Carbon; D005947:Glucose