Antitumour and anti-AIDS triterpenes from Celastrus hindsii.
Four new triterpene compounds, celasdin-A, celasdin-C, anti-AIDS celasdin-B and cytotoxic maytenfolone-A, were isolated from Celastrus hindsii. The structural determination of maytenfolone-A, celasdin-A, celasdin-B and celasdin-C, as well as the structure-activity relationships of these new compounds and derivatives, are discussed. Maytenfolone-A was further confirmed by X-ray studies. Biological evaluation showed that Maytenfolone-A demonstrated cytotoxicity against hepatoma (HEPA-2B, ED50 = 2.3 micrograms ml-1) and nasopharynx carcinoma (KB, ED50 = 3.8 micrograms ml-1). Celasdin-B was found to exhibit anti-HIV replication activity in H9 lymphocyte cells with an EC50 of 0.8 microgram ml-1).
Kuo
Y H
YH
National Research Institute of Chinese Medicine, Taipei, Taiwan, R.O.C.
Kuo
L M
LM
D019380:Anti-HIV Agents / Q000302:isolation & purification* / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology; D006678:HIV / Q000187:drug effects / Q000502:physiology; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D010944:Plants / Q000737:chemistry*; D014315:Triterpenes / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured; D014779:Virus Replication / Q000187:drug effects
D019380:Anti-HIV Agents; D000972:Antineoplastic Agents, Phytogenic; D014315:Triterpenes