title: The organisations of hereditary information.
abstract: The meaning of hereditary information is not simple. It includes not only what a system receives and transmits but particularly what it makes. The syntactic basis to hereditary information is also not straightforward. For example, is DNA instructions, or data, or both? The answer to this question requires an appreciation of the meaning of the information yet there are a number of possible semantic systems for describing hereditary information including proteins and development. The descriptive boundaries of hereditary information are examined by locating some general organising themes including hierarchy, ecology, regulation, epigenetic systems and talkback. Though metaphors have limits in terms of their explanatory power a number have influenced the development of biological thinking and biosystems have variously been represented as chemical laboratories, computers, electromechanical machines and societies. In this article a further metaphor is discussed, that of life-as-a-play or dance in which the trio of script (genome), cast (metabolism) and stage (cellular structure) co-exist and pre-exist the phenotypic life history which inherits them. A fuller examination of this trio provides an important perspective on the study of the organisations of information processing in hereditary systems.
authors.affiliation: Department of Computer Science, University of Liverpool, UK. r.c.paton@csc.liv.ac.uk
authors.forename: R
authors.initials: R
authors.lastname: Paton
mesh_terms: D005815:Genetic Code; D016678:Genome; D008957:Models, Genetic