Impulsive aggression in personality disorder correlates with platelet 5-HT2A receptor binding.
The purpose of this study was to examine the relationship between platelet 5-HT2A receptor binding and aggressive behavior. 125I-LSD Bmax and Kd values were measured for 22 subjects meeting DMS-III-R criteria for one or more personality disorders and 12 healthy volunteer subjects. Aggression and impulsivity were assessed using the Buss-Durkee Hostility Inventory (BDHI) Assault scale, Life History of Aggression (LHA) scale, and the Barratt-11 Impulsiveness scale (BIS-11). Bmax and Kd values did not differ between personality disordered subjects and healthy volunteers. However, both Bmax and Kd values correlated positively with BDHI Assault scores in personality-disordered subjects but not in healthy volunteer subjects. These results suggest that assaultiveness in personality-disordered subjects may covary with increasing numbers, but decreasing affinity, of platelet 5-HT2A receptor sites labeled by 125I-LSD.
Coccaro
E F
EF
Department of Psychiatry, Medical College of Pennsylvania, Philadelphia 19129, USA.
Kavoussi
R J
RJ
Sheline
Y I
YI
Berman
M E
ME
Csernansky
J G
JG
D000328:Adult; D000374:Aggression / Q000502:physiology*; D001792:Blood Platelets / Q000378:metabolism*; D005260:Female; D006801:Humans; D008238:Lysergic Acid Diethylamide / Q000378:metabolism; D008297:Male; D010554:Personality Disorders / Q000378:metabolism / Q000503:physiopathology*; D011569:Psychiatric Status Rating Scales; D044402:Receptor, Serotonin, 5-HT2A; D011985:Receptors, Serotonin / Q000378:metabolism*; D012702:Serotonin Antagonists / Q000378:metabolism
D044402:Receptor, Serotonin, 5-HT2A; D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D008238:Lysergic Acid Diethylamide