Enterobacteria-infected T cells as antigen-presenting cells for cytotoxic CD8 T cells: a contribution to the self-limitation of cellular immune reactions in reactive arthritis?
In enterobacteria-induced reactive arthritis (ReA), different T cell subsets play a role in the induction and maintenance of the synovitic process. Synovial fluid-derived alphabeta CD4, alphabeta CD8, and gammadelta T lymphocyte clones (TLC) that recognize Yersinia or Salmonella antigens on professional antigen-presenting cells (APC) have been characterized, and T cells themselves can function as nonprofessional APC. T cells were infected with the facultatively intracellular, arthritogenic enterobacterium Yersinia enterocolitica O:3. A CD8 TLC isolated from a patient with Yersinia-induced ReA recognized and efficiently lysed autologous and allogeneic Yersinia-infected T cells. Infected cytotoxic T lymphocytes (CTL) had a reduced lytic capacity against syngeneic and allogeneic infected target cells, suggesting that the infection of CTL by bacteria may represent a mechanism of immune escape. In ReA, antigen presentation by T cells may modify the antibacterial immune response and may also contribute to network control mechanisms of T cell-mediated cytotoxicity.
Ackermann
B
B
First Department of Medicine, Johannes Gutenberg-University of Mainz, Germany.
Staege
M S
MS
Reske-Kunz
A B
AB
Dienes
H P
HP
Meyer zum Büschenfelde
K H
KH
Märker-Hermann
E
E
D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology / Q000382:microbiology*; D000942:Antigens, Bacterial / Q000276:immunology*; D016918:Arthritis, Reactive / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology / Q000382:microbiology; D002999:Clone Cells; D006801:Humans; D007111:Immunity, Cellular; D007739:L Cells; D051379:Mice; D008854:Microscopy, Electron; D000091402:Prohibitins; D012486:Salmonella typhimurium / Q000276:immunology*; D016176:T-Lymphocyte Subsets / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology / Q000382:microbiology* / Q000648:ultrastructure; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology / Q000382:microbiology*; D014407:Tumor Cells, Cultured; D015009:Yersinia Infections / Q000276:immunology*; D015008:Yersinia enterocolitica / Q000276:immunology*
D000942:Antigens, Bacterial; C000717331:PHB2 protein, human; D000091402:Prohibitins