Interleukin-1 receptor blockade attenuates oxygen-derived free radical production and microcirculatory disturbances in ischemia/reperfusion injury in the liver.
Shirasugi
N
N
Department of Surgery, Keio University School of Medicine, Tokyo, Japan.
Wakabayashi
G
G
Shimazu
M
M
Shito
M
M
Kawachi
S
S
Kitajima
M
M
D000818:Animals; D002448:Cell Adhesion; D005260:Female; D005609:Free Radicals / Q000378:metabolism; D006801:Humans; D053590:Interleukin 1 Receptor Antagonist Protein; D007375:Interleukin-1 / Q000502:physiology; D007700:Kinetics; D007962:Leukocytes / Q000502:physiology*; D008099:Liver / Q000098:blood supply* / Q000187:drug effects / Q000378:metabolism; D008102:Liver Circulation / Q000187:drug effects / Q000502:physiology*; D008163:Luminescent Measurements; D008833:Microcirculation / Q000187:drug effects / Q000503:physiopathology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D017472:Receptors, Interleukin-1 / Q000037:antagonists & inhibitors*; D011994:Recombinant Proteins / Q000494:pharmacology; D015427:Reperfusion Injury / Q000503:physiopathology* / Q000517:prevention & control; D012795:Sialoglycoproteins / Q000494:pharmacology*
D005609:Free Radicals; C507763:IL1RN protein, human; D053590:Interleukin 1 Receptor Antagonist Protein; D007375:Interleukin-1; D017472:Receptors, Interleukin-1; D011994:Recombinant Proteins; D012795:Sialoglycoproteins