title: Evaluation of the effects of intravascular MR contrast media (gadolinium dendrimer) on 3D time of flight magnetic resonance angiography of the body.
abstract: The aims of this preliminary study were to establish the efficacy and minimum effective dose of TG(5)(FdDO3A)(52) gadolinium dendrimer for contrast-enhanced, three-dimensional (3D) time of flight (TOF) magnetic resonance angiography (MRA) of the body. In a dose ranging study in eight rabbits (Group A), each of two animals received 0.03; 0.02; 0.01; or 0.005 mmol/kg of the agent for 3D-TOF MRA of the pelvic circulation in the axial and coronal planes. An additional nine animals (Group B) received a dose of 0.02 mmol/kg for 3D-TOF MRA of the mediastinum, abdomen or of the lower limbs. Quantitative and qualitative analyses of the images from Group A demonstrated a dose-related reduction in saturation effects and improved visualization of vascular structures, with maximal augmentation of the contrast-to-noise ratio (CNR) at 0.03 mmol/kg. The dose of 0.02 mmol/kg was found to be the minimal effective dose at the three vascular regions.
authors.affiliation: Department of Radiology, University of California, San Francisco, CA, USA.
authors.forename: M W
authors.initials: MW
authors.lastname: Bourne
authors.forename: L
authors.initials: L
authors.lastname: Margerun
authors.forename: N
authors.initials: N
authors.lastname: Hylton
authors.forename: B
authors.initials: B
authors.lastname: Campion
authors.forename: J J
authors.initials: JJ
authors.lastname: Lai
authors.forename: N
authors.initials: N
authors.lastname: Derugin
authors.forename: C B
authors.initials: CB
authors.lastname: Higgins
mesh_terms: D000818:Animals; D001808:Blood Vessels / Q000033:anatomy & histology*; D003287:Contrast Media; D005260:Female; D005682:Gadolinium / Q000008:administration & dosage / Q000493:pharmacokinetics; D007091:Image Processing, Computer-Assisted; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008297:Male; D011817:Rabbits
chemical_list: D003287:Contrast Media; D005682:Gadolinium