The effects of diltiazem on superior mesenteric artery ligation. An experimental study.
The effects of diltiazem on an experimental study of Superior Mesenteric Artery ligation were studied on three rat groups comprising controls (N = 5), SMA ligation (N = 8), and SMA ligation and diltizem (0.25 mg/kg injection), (N = 8). Creatine phosphokinase, lactic dehydrogenase, aspartate transaminase and alanine transaminase venous blood levels were significantly decreased after diltiazem injection compared with the SMA ligation group. Histopathologic examinations revealed that diltiazem partly protected the small intestine from ischemic changes.
Topaloğlu
U
U
4th Surgical Clinic, Haydarpaşa State Hospital, Istanbul, Turkey.
Yilmazcan
A
A
Peker
O
O
Diren
S
S
Türkalp
I
I
Unalmişer
S
S
D000818:Animals; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D004110:Diltiazem / Q000494:pharmacology*; D005260:Female; D007421:Intestine, Small / Q000098:blood supply / Q000187:drug effects; D007511:Ischemia / Q000517:prevention & control; D008026:Ligation; D017538:Mesenteric Artery, Superior / Q000601:surgery; D051381:Rats; D017208:Rats, Wistar; D013152:Splanchnic Circulation / Q000187:drug effects*
D002121:Calcium Channel Blockers; D004110:Diltiazem