title: [Evaluation by poison control centers of minaprine from the modification of tablet dosages].
abstract: By 1990, the Clin Midy (SANOFI) laboratory had modified the dose of Cantor tablets: the content of active drug (minaprine) increased (50 to 100 mg). Therefore, acute intoxication by minaprine can be serious, with generalized seizures, resisting the classic treatment. We tried to evaluate the possible consequences of this change of dose for the gravity of suicide attempts. 1091 voluntary acute intoxications have been collected by the national French Poisons Centres data bank, 226 of them by the Poisons center of Marseilles. We have compared, by the chi 2 method, the frequencies of seizure and death, before and after 1990. Results are significant, confirming an increased gravity of these intoxications since the modification of dosage. Then, the laboratory reduced the number of tablets per box. We don't know if this measure will be efficient.
authors.affiliation: Centre antipoisons de Marseille-Hôpital Salvator.
authors.forename: J
authors.initials: J
authors.lastname: Jouglard
authors.forename: C
authors.initials: C
authors.lastname: Perringue
authors.forename: J
authors.initials: J
authors.lastname: Goujard
authors.forename: A
authors.initials: A
authors.lastname: Servetti
authors.forename: J M
authors.initials: JM
authors.lastname: David
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000928:Antidepressive Agents / Q000008:administration & dosage* / Q000506:poisoning*; D002648:Child; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009026:Mortality; D011039:Poison Control Centers / Q000706:statistics & numerical data; D011724:Pyridazines / Q000008:administration & dosage* / Q000506:poisoning*; D012640:Seizures / Q000139:chemically induced / Q000453:epidemiology; D013406:Suicide, Attempted / Q000706:statistics & numerical data; D013607:Tablets
chemical_list: D000928:Antidepressive Agents; D011724:Pyridazines; D013607:Tablets; C006149:minaprine