title: Subretinal fibrosis in central serous chorioretinopathy.
abstract: OBJECTIVE
  To report unusual and heretofore unreported visually damaging manifestations of severe central serous chorioretinopathy.
  
  
  METHODS
  Case studies.
  
  
  RESULTS
  Each of six male patients (average age, 40 years) had a form of severe central serous chorioretinopathy with at least one eye containing fibrin in the subretinal space that then developed into a subretinal fibrotic scar. Scar formation was followed by a tenting up of the macula, vascularization of the fibrosis (subretinal neovascularization), or a retinal pigment epithelial rip. Four of the seven eyes with subretinal fibrosis had severe visual loss (20/400 or worse).
  
  
  CONCLUSIONS
  Subretinal fibrin and other extracellular matrix molecules appear to stimulate the retinal pigment epithelium to undergo fibrous metaplasia, which results in subretinal fibrotic scar formation and other sequelae, all of which can lead to severe visual loss.
authors.affiliation: Retina Research Fund, St. Mary's Medical Center, San Francisco, CA, USA.
authors.forename: H
authors.initials: H
authors.lastname: Schatz
authors.forename: H R
authors.initials: HR
authors.lastname: McDonald
authors.forename: R N
authors.initials: RN
authors.lastname: Johnson
authors.forename: C K
authors.initials: CK
authors.lastname: Chan
authors.forename: A R
authors.initials: AR
authors.lastname: Irvine
authors.forename: A R
authors.initials: AR
authors.lastname: Berger
authors.forename: J C
authors.initials: JC
authors.lastname: Folk
authors.forename: D M
authors.initials: DM
authors.lastname: Robertson
mesh_terms: D000328:Adult; D001826:Body Fluids; D015862:Choroid Diseases / Q000150:complications* / Q000473:pathology; D005122:Exudates and Transudates; D005337:Fibrin; D005355:Fibrosis / Q000209:etiology; D005451:Fluorescein Angiography; D005654:Fundus Oculi; D006801:Humans; D008297:Male; D008875:Middle Aged; D012160:Retina / Q000473:pathology*; D012163:Retinal Detachment / Q000209:etiology / Q000473:pathology; D012164:Retinal Diseases / Q000150:complications* / Q000473:pathology; D014786:Vision Disorders / Q000209:etiology; D014792:Visual Acuity
chemical_list: D005337:Fibrin