N-acetyl-S-(dichlorophenyl)cysteines as suitable biomarkers for the monitoring of occupational exposure to 1,2-dichlorobenzene.
A method has been developed for the simultaneous analysis of the isomeric N-acetyl-S-(dichlorophenyl)cysteines (also known as dichlorophenylmercapturic acids, DCPMAs) in urine. This procedure allows the determination of 2,3- and 3,4-DCPMAs at the concentrations expected in the urine samples of employees occupationally exposed to 1,2-dichlorobenzene (1,2-DCB). The results of a 1,2-DCB exposure study under standardized conditions show a first-order kinetic for the excretion of DCPMAs, as well as acceptable linear correlations between the urinary concentrations of DCPMAs and the amount of inhaled 1,2-DCB. It therefore seems it would be possible to derive a biological tolerance value for 1,2-DCB based on isomeric DCPMAs as analytical parameters.
Zenser
L P
LP
Institut und Poliklinik für Arbeits und Sozialmedizin, Justus-Liebig-Universität, Giessen, Germany.
Lang
A
A
Knecht
U
U
D000111:Acetylcysteine / Q000031:analogs & derivatives* / Q000652:urine; D015415:Biomarkers / Q000652:urine*; D002722:Chlorobenzenes / Q000378:metabolism*; D004784:Environmental Monitoring / Q000379:methods*; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D007306:Insecticides / Q000378:metabolism*; D009784:Occupational Diseases / Q000209:etiology / Q000652:urine*; D016273:Occupational Exposure / Q000009:adverse effects
D015415:Biomarkers; D002722:Chlorobenzenes; D007306:Insecticides; C107354:N-acetyl-S-(3,4-dichlorophenyl)cysteine; C004726:2-dichlorobenzene; C107355:N-acetyl-S-(2,3-dichlorophenyl)cysteine; D000111:Acetylcysteine