Caudate nucleus area in drug-induced parkinsonism.
This study examined caudate nuclei areas in 10 schizophrenic subjects with and 25 schizophrenic subjects without parkinsonian symptoms. The subjects with parkinsonian symptoms were found to have statistically significantly smaller right caudate nuclei and a trend towards smaller left caudates. Cortical measurements did not differ between the groups. These results are consistent with the suggestion that antipsychotic drugs exert some neurotoxic effects, but should be viewed as preliminary and require replication.
Brown
K W
KW
Central Scotland Healthcare NHS Trust, Bellsdyke Hospital, Larbert, Scotland, UK.
Wardlaw
J M
JM
White
T
T
Walker
N
N
D000368:Aged; D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001931:Brain Mapping; D002421:Caudate Nucleus / Q000000981:diagnostic imaging / Q000187:drug effects*; D004292:Dominance, Cerebral / Q000187:drug effects / Q000502:physiology; D005260:Female; D006801:Humans; D008134:Long-Term Care; D008297:Male; D008875:Middle Aged; D010302:Parkinson Disease, Secondary / Q000139:chemically induced* / Q000000981:diagnostic imaging; D012016:Reference Values; D012559:Schizophrenia / Q000188:drug therapy*; D012606:Scotland; D014057:Tomography, X-Ray Computed
D014150:Antipsychotic Agents