title: An interactive Web site providing major histocompatibility ligand predictions: application to HIV research.
abstract: EpiMatrix/HIV, a tool that is currently available on the World Wide Web, enables researchers to screen HIV proteins for potential MHC ligands. We have performed a comparison of EpiMatrix predictions to 158 published allotype-specific HLA-associated peptides (MHC ligands) derived from 133 proteins. The top 10 ranked EpiMatrix predictions for each of the 158 HLA allotype-protein pairs were selected for comparison with these published ligands. EpiMatrix correctly identified 134 of 158 published ligands (85%). The algorithm is now available for use by the HIV research community at the URL http:/(/)www.EpiMatrix.com/HIV.
authors.affiliation: TB/HIV Research Laboratory, Brown University School of Medicine, Providence, Rhode Island 02912, USA.
authors.forename: A S
authors.initials: AS
authors.lastname: De Groot
authors.forename: B M
authors.initials: BM
authors.lastname: Jesdale
authors.forename: E
authors.initials: E
authors.lastname: Szu
authors.forename: J R
authors.initials: JR
authors.lastname: Schafer
authors.forename: R M
authors.initials: RM
authors.lastname: Chicz
authors.forename: G
authors.initials: G
authors.lastname: Deocampo
mesh_terms: D003195:Computer Communication Networks / Q000458:organization & administration; D001330:Electronic Data Processing; D015658:HIV Infections / Q000276:immunology*; D006680:HLA Antigens / Q000276:immunology; D006801:Humans; D008285:Major Histocompatibility Complex / Q000276:immunology*; D010455:Peptides / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D006680:HLA Antigens; D010455:Peptides