Apoptosis as a possible cause of wall thinning in end-stage hypertrophic cardiomyopathy.
A 15-year-old boy with hypertrophic cardiomyopathy died of congestive heart failure with progressive left ventricular wall thinning with poor systolic function. Microscopic examination revealed patchy fibrosis in the ventricular myocardium with wall thinning, and immunohistochemical evaluation of apoptosis showed apoptotic cells and bodies in the destroyed myocytes along the border between the fibrotic area and myofibril.
Ino
T
T
Department of Pediatrics, Juntendo University School of Medicine, Tokyo, Japan.
Nishimoto
K
K
Okubo
M
M
Akimoto
K
K
Yabuta
K
K
Kawai
S
S
Okada
R
R
Sueyoshi
N
N
D000293:Adolescent; D017209:Apoptosis; D002312:Cardiomyopathy, Hypertrophic / Q000150:complications / Q000473:pathology* / Q000503:physiopathology*; D004452:Echocardiography; D017809:Fatal Outcome; D006333:Heart Failure / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D018487:Ventricular Dysfunction, Left / Q000150:complications / Q000209:etiology / Q000473:pathology / Q000503:physiopathology