Growth performance, endocrine, and metabolite responses of finishing hogs to porcine prolactin.
Prolactin, a member of the somatotropin-prolactin-placental lactogen gene family, increases feed intake and rate of weight gain in several species. To determine whether prolactin affects growth performance and carcass composition in swine, recombinant porcine prolactin (rpPRL) was administered to finishing hogs. Doses of 0, 2, 4, 8, and 16 mg of rpPRL/d and 4 mg of recombinant porcine somatotropin (rpST)/d were administered to groups of seven barrows and seven gilts initially weighing 75.0 +/- .2 kg for a 28-d period. Recombinant pPRL did not alter feed intake or growth rate or affect carcass composition. In addition, most growth-related blood variables did not change, although plasma IGF-I was increased in the 8 and 16 mg of rpPRL treatment groups. At slaughter, mammary development was apparent in rpPRL-treated gilts and was characterized by distended alveolar and ductal lumina and presence of secretory material. In rPST-treated hogs, feed intake was decreased 28% (P < .01), gain/feed was increased more in barrows than in gilts (59 vs 39%, treatment x sex interaction, P = .035), and growth rate was increased 22%, but in barrows only (treatment x sex interaction P = .005). Compared with those in control hogs, circulating concentrations of IGF-I, insulin, and glucose were 175, 311, and 22% higher, respectively, and of blood urea nitrogen were 62% lower in rpST-treated hogs (P < .05). These results suggest that rpPRL, at the doses administered, does not increase feed intake in finishing hogs in contrast to rats and other species.
McLaughlin
C L
CL
Protiva Unit of Monsanto Company, St. Louis, MO 63198, USA.
Byatt
J C
JC
Curran
D F
DF
Veenhuizen
J J
JJ
McGrath
M F
MF
Buonomo
F C
FC
Hintz
R L
RL
Baile
C A
CA
D000704:Analysis of Variance; D000818:Animals; D001786:Blood Glucose / Q000032:analysis / Q000378:metabolism; D001806:Blood Urea Nitrogen; D001823:Body Composition / Q000187:drug effects / Q000502:physiology; D050260:Carbohydrate Metabolism; D004396:Coloring Agents; D004305:Dose-Response Relationship, Drug; D004435:Eating / Q000187:drug effects / Q000502:physiology; D004702:Endocrine Glands / Q000187:drug effects / Q000502:physiology*; D005260:Female; D013006:Growth Hormone / Q000008:administration & dosage / Q000494:pharmacology; D007267:Injections; D007328:Insulin / Q000097:blood; D007334:Insulin-Like Growth Factor I / Q000032:analysis / Q000378:metabolism; D007457:Iodine Radioisotopes; D008297:Male; D008321:Mammary Glands, Animal / Q000166:cytology / Q000502:physiology; D018482:Muscle, Skeletal / Q000033:anatomy & histology / Q000187:drug effects; D011388:Prolactin / Q000008:administration & dosage / Q000494:pharmacology*; D011506:Proteins / Q000378:metabolism; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000494:pharmacology; D013552:Swine / Q000254:growth & development* / Q000378:metabolism* / Q000502:physiology; D015430:Weight Gain / Q000187:drug effects / Q000502:physiology
D001786:Blood Glucose; D004396:Coloring Agents; D007328:Insulin; D007457:Iodine Radioisotopes; D011506:Proteins; D011994:Recombinant Proteins; D007334:Insulin-Like Growth Factor I; D011388:Prolactin; D013006:Growth Hormone