Humoral and cell-mediated immune responses following lesions of the nucleus basalis magnocellularis in the rat.
The present study was undertaken to elucidate whether electrolytic lesions of nucleus basalis magnocellularis--NBM (an animal model of Alzheimer's disease--AD) may influence humoral and cellular immune responses in adult male Wistar rats. For this purpose intact control (IC), sham-operated (SO) and NBM-lesioned rats were divided into two main groups: (1) rats immunized with sheep red blood cells (SRBC) for plaque-forming cell (PFC) response and anti-SRBC agglutinins, and (2) rats immunized with bovine serum albumin in complete Freund's adjuvant (BSA-CFA) for anti-BSA antibody production, Arthus and delayed hypersensitivity skin reaction to BSA. PFC responses and anti-SRBC agglutinins as well as diameter and expression of edema/induration of Arthus/delayed skin reaction and titer of anti-BSA antibody were significantly lower in NBM lesioned rats (compared to IC and SO). The results showed that in NBM-lesioned rats both the humoral and cellular immune responses were suppressed.
Popović
M
M
Immunology Research Center Branislav Jankovic.
Jovanova-Nesić
K
K
Popović
N
N
Ugresić
N
N
Kostić
V
V
Rakić
L
L
D000372:Agglutination Tests; D000544:Alzheimer Disease / Q000276:immunology*; D000818:Animals; D000917:Antibody Formation / Q000502:physiology*; D001183:Arthus Reaction; D001479:Basal Ganglia / Q000293:injuries* / Q000502:physiology; D001835:Body Weight / Q000502:physiology; D004912:Erythrocytes / Q000276:immunology; D006412:Hematopoietic Stem Cells; D006967:Hypersensitivity / Q000276:immunology; D007111:Immunity, Cellular / Q000502:physiology*; D008297:Male; D009929:Organ Size / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D012882:Skin Tests