title: Cloning and characterization of the cDNA encoding mouse dipeptidyl peptidase I (cathepsin C).
abstract: The mouse dipeptidyl peptidase I cDNA has been cloned and sequenced and patterns of DPPI mRNA expression in various tissues characterized. Sequences encoding DPPI are highly conserved among mouse, rat and human and include an unusually long propeptide and a distinctive tyrosine adjacent to the active site cysteine.
authors.affiliation: Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas 75235-8577, USA. mjmcguir@ix.netcom.com
authors.forename: M J
authors.initials: MJ
authors.lastname: McGuire
authors.forename: P E
authors.initials: PE
authors.lastname: Lipsky
authors.forename: D L
authors.initials: DL
authors.lastname: Thiele
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D001665:Binding Sites; D015152:Blotting, Northern; D019556:COS Cells; D020789:Cathepsin C; D003001:Cloning, Molecular; D017124:Conserved Sequence; D003546:Cysteine Endopeptidases / Q000235:genetics; D018076:DNA, Complementary / Q000235:genetics; D004152:Dipeptidyl-Peptidases and Tripeptidyl-Peptidases / Q000235:genetics* / Q000378:metabolism*; D006801:Humans; D051379:Mice; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D051381:Rats; D011994:Recombinant Proteins / Q000235:genetics / Q000378:metabolism; D017422:Sequence Analysis, DNA; D017386:Sequence Homology, Amino Acid; D014018:Tissue Distribution; D014162:Transfection
chemical_list: D018076:DNA, Complementary; D011994:Recombinant Proteins; D004152:Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; D020789:Cathepsin C; D003546:Cysteine Endopeptidases