Correlation of susceptibility and resistance of twenty-five bacterial strains by analysis of MIC database of cephalosporins and oxacephalosporins.
MIC database of 1,407 cephalosporins and oxacephalosporins was utilized to characterize 25 bacterial strains including Gram-positive and Gram-negative bacteria. MIC values were converted to activity rank indices, and distribution patterns of these indices were compared among the bacterial strains. Salmonella enteritidis. No. 11 was the most susceptible bacterium, and the activity against this strain was ascribed to the binding of beta-lactams to the PBPs without any significant barrier to the approach of beta-lactams. Twenty-one strains were assumed to have similar types of PBPs to those of S. enteritidis No. 11 in the binding profile to beta-lactams. Comparison of the scatter diagrams of the activity rank indices revealed two different types of resistances arising from beta-lactamases (9 strains) and outer membrane permeability and/or active efflux (15 strains). The resistance factor arising from beta-lactamase was affected by the nature of the C-3 substituents of beta-lactams.
Kodama
Y
Y
Pharmaceutical Research Center, Meiji Seika Kaisha, Yokohama, Japan.
Inouye
S
S
D001419:Bacteria / Q000187:drug effects*; D002511:Cephalosporins / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D007256:Information Systems; D008826:Microbial Sensitivity Tests; D012477:Salmonella enteritidis / Q000187:drug effects; D013329:Structure-Activity Relationship
D002511:Cephalosporins