Effect of gentamicin dosing interval on efficacy of penicillin or ceftriaxone treatment of experimental endocarditis due to penicillin-susceptible, ceftriaxone-tolerant viridans group streptococci.
The efficacy of ceftriaxone or penicillin alone or combined with gentamicin at different dosing intervals was evaluated in experimental endocarditis due to a penicillin-susceptible, ceftriaxone-tolerant strain of Streptococcus sanguis I. The difference between monotherapy with ceftriaxone and procaine penicillin approached statistical significance (P = 0.052). Ceftriaxone combined with gentamicin administered as a single daily dose was less effective than was procaine penicillin combined with gentamicin administered in a single daily dose or in three divided doses.
Brandt
C M
CM
Division of Infectious Diseases, Mayo Clinic, Rochester, Minnesota 55905, USA.
Warner
C B
CB
Rouse
M S
MS
Steckelberg
J M
JM
Wilson
W R
WR
D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D002443:Ceftriaxone / Q000008:administration & dosage / Q000627:therapeutic use; D004352:Drug Resistance, Microbial; D004359:Drug Therapy, Combination / Q000008:administration & dosage* / Q000627:therapeutic use; D004697:Endocarditis, Bacterial / Q000188:drug therapy*; D005839:Gentamicins / Q000008:administration & dosage / Q000627:therapeutic use; D008826:Microbial Sensitivity Tests; D010402:Penicillin G Procaine / Q000008:administration & dosage / Q000627:therapeutic use; D011817:Rabbits; D013290:Streptococcal Infections / Q000188:drug therapy*; D013298:Streptococcus sanguis / Q000187:drug effects*
D000900:Anti-Bacterial Agents; D005839:Gentamicins; D010402:Penicillin G Procaine; D002443:Ceftriaxone