title: Response of low density lipoprotein cholesterol levels to dietary change: contributions of different mechanisms.
abstract: In many individuals, LDL-cholesterol levels rise following increased consumption of dietary cholesterol or saturated and trans-monounsaturated fatty acids. In others, a reduction of cholesterogenesis fully compensates for these effects. In responding individuals, much of the increase in LDL-cholesterol observed may result directly from an increase in plasma cholesteryl ester transfer protein activity whose effect is not mediated by hepatic LDL receptors.
authors.affiliation: Cardiovascular Research Institute, University of California, San Francisco 94143, USA.
authors.forename: C J
authors.initials: CJ
authors.lastname: Fielding
mesh_terms: D002352:Carrier Proteins / Q000097:blood; D053480:Cholesterol Ester Transfer Proteins; D002791:Cholesterol, Dietary / Q000008:administration & dosage*; D008078:Cholesterol, LDL / Q000096:biosynthesis / Q000097:blood*; D004041:Dietary Fats / Q000008:administration & dosage*; D015536:Down-Regulation; D005227:Fatty Acids / Q000008:administration & dosage; D006023:Glycoproteins; D006801:Humans
chemical_list: C506642:CETP protein, human; D002352:Carrier Proteins; D053480:Cholesterol Ester Transfer Proteins; D002791:Cholesterol, Dietary; D008078:Cholesterol, LDL; D004041:Dietary Fats; D005227:Fatty Acids; D006023:Glycoproteins