Changes in symptomatology, hormones, lipids, and bone density after hysterectomy.
OBJECTIVE
To evaluate the differences in symptoms, hormone and lipid levels, and bone density in two groups of women.


METHODS
Two hundred eighty-five women who attended for climacteric study with previous simple hysterectomy were studied. Three groups were formed according to time since surgery (group I < 10 years, group II > or = 10 and < 20 years, and group III > or = 20 years). They were paired by age with a group without hysterectomy (control group) that also attended for climacteric study. None of them were receiving nor had received hormone replacement therapy. Age, body mass index, gestations, deliveries, and climacteric symptoms were analyzed for all subjects. Follicle-stimulating hormone (FSH), estradiol, total cholesterol, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol and triglyceride levels were determined, and atherogenic index was calculated. Bone density was measured with a Lunar DPXL appliance. Statistical analysis was done by the chi-square test, Student's t test, and linear regression analysis.


RESULTS
There were no differences among groups in body mass index, gestations, or deliveries. Depression was more frequent in the hysterectomy group, who also had lower levels of total cholesterol, HDL cholesterol, and FSH than controls.


CONCLUSIONS
It was observed that hysterectomy does not have a deleterious effect on hormone or lipid levels, nor on bone density, but depression was a frequent finding in hysterectomized women.
Carranza-Lira
S
S
Center for the Study of the Climacteric and the Menopause (CECLIMEN), Hospital de México, Mexico City, Mexico, USA.
Murillo-Uribe
A
A
Martínez Trejo
N
N
Santos-González
J
J
D015519:Bone Density; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D002979:Climacteric / Q000097:blood / Q000502:physiology* / Q000523:psychology; D015331:Cohort Studies; D003863:Depression / Q000453:epidemiology* / Q000209:etiology; D004958:Estradiol / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006728:Hormones / Q000097:blood*; D006801:Humans; D007044:Hysterectomy / Q000009:adverse effects*; D007989:Libido; D008055:Lipids / Q000097:blood*; D008875:Middle Aged; D012016:Reference Values; D012044:Regression Analysis; D014280:Triglycerides / Q000097:blood
D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D006728:Hormones; D008055:Lipids; D014280:Triglycerides; D004958:Estradiol; D005640:Follicle Stimulating Hormone