Effect of chronic treatment with imipramine on interleukin 1 and interleukin 2 production by splenocytes obtained from rats subjected to a chronic mild stress model of depression.
A depression-like state was induced by chronic (3-week) exposure of Wistar rats to a very mild, unpredictable stress which is a model of depression, developed by Willner's group. Five-week daily administration of imipramine reversed the stress-induced deficit in sucrose consumption. Eight-week stress induced an increase in the ability of splenocytes to produce interleukin 1 (IL-1) and interleukin 2 (IL-2) and to proliferate after stimulation with concanavalin A. Antidepressant effects of imipramine were accompanied by a decrease in the ability of splenocytes to produce IL-1 and IL-2 and to proliferate. Administration of imipramine alone did not modify the activity of those cells.
Kubera
M
M
Institute of Pharmacology, Polish Academy of Sciences, Kraków, Poland.
Symbirtsev
A
A
Basta-Kaim
A
A
Borycz
J
J
Roman
A
A
Papp
M
M
Claesson
M
M
D000818:Animals; D000929:Antidepressive Agents, Tricyclic / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D002908:Chronic Disease; D003208:Concanavalin A / Q000494:pharmacology; D003863:Depression / Q000378:metabolism*; D007099:Imipramine / Q000494:pharmacology*; D007375:Interleukin-1 / Q000096:biosynthesis*; D007376:Interleukin-2 / Q000096:biosynthesis*; D015850:Interleukin-6 / Q000096:biosynthesis; D008297:Male; D008934:Mitogens / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013154:Spleen / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D013315:Stress, Psychological / Q000378:metabolism*
D000929:Antidepressive Agents, Tricyclic; D007375:Interleukin-1; D007376:Interleukin-2; D015850:Interleukin-6; D008934:Mitogens; D003208:Concanavalin A; D007099:Imipramine