A 41-kDa antigen of the rodent filaria Acanthocheilonema viteae with homologies to tropomyosin induces host-protective immune responses.
A purified 41-kDa protein of the rodent filaria Acanthocheilonema viteae was shown to protect jirds against a challenge infection. Subcutaneous immunization with the protein reduced the number of adult worms by up to 65% and the number of circulating microfilariae declined by up to 93% in these animals. The protein is located in the muscle tissues of adult worms and was identified as tropomyosin by N-terminal sequencing of the purified protein.
Hartmann
S
S
Department of Molecular Parasitology, Humboldt University, Berlin, Germany.
Adam
R
R
Marti
T
T
Kirsten
C
C
Seidinger
S
S
Lucius
R
R
D000595:Amino Acid Sequence; D000818:Animals; D000947:Antigens, Helminth / Q000737:chemistry / Q000627:therapeutic use*; D004153:Dipetalonema / Q000276:immunology*; D004154:Dipetalonema Infections / Q000517:prevention & control*; D005260:Female; D005849:Gerbillinae / Q000276:immunology / Q000469:parasitology*; D008297:Male; D008969:Molecular Sequence Data; D012376:Rodent Diseases / Q000517:prevention & control*; D017421:Sequence Analysis; D017386:Sequence Homology, Amino Acid; D014335:Tropomyosin / Q000737:chemistry; D014611:Vaccination
D000947:Antigens, Helminth; D014335:Tropomyosin