title: Post-radiation valvular and coronary artery disease.
abstract: The authors report a case of mitro-aortic valvulopathy associated with single-vessel coronary disease, both probably caused by thoracic irradiation, initially for Hodgkin's lymphoma, and later for carcinoma of the breast. The patient was subjected to aortic valve replacement with a mechanical prosthesis, partial mitral annuloplasty and myocardial revascularization. This report underscores the importance of long-term follow up of patients subjected to mediastinal radiotherapy, because of the significant cardiac morbidity caused by this type of treatment.
authors.affiliation: University Hospital, Coimbra, Portugal.
authors.forename: A T
authors.initials: AT
authors.lastname: Gonzaga
authors.forename: M J
authors.initials: MJ
authors.lastname: Antunes
mesh_terms: D001022:Aortic Valve Insufficiency / Q000209:etiology* / Q000601:surgery; D001943:Breast Neoplasms / Q000532:radiotherapy; D017023:Coronary Angiography; D001026:Coronary Artery Bypass; D003327:Coronary Disease / Q000209:etiology* / Q000601:surgery; D018572:Disease-Free Survival; D005260:Female; D006350:Heart Valve Prosthesis; D006689:Hodgkin Disease / Q000532:radiotherapy; D006801:Humans; D008875:Middle Aged; D008944:Mitral Valve Insufficiency / Q000209:etiology* / Q000601:surgery; D011832:Radiation Injuries / Q000150:complications* / Q000175:diagnosis