title: Olaquindox-induced airborne photoallergic contact dermatitis followed by transient or persistent light reactions in 15 pig breeders.
abstract: There have been no previous reports of photosensitivity following photoallergy to airborne olaquindox in a large group. 15 pig breeders, with photo-distributed dermatitis related to olaquindox dust, were investigated to study the nature, promoting factors, and course of this disease. Minimal erythema doses for UVA and UVB were established before photopatch testing and at intervals thereafter. All patients presented with olaquindox-induced photoallergy. In 14 cases, this was followed by prolonged increased sensitivity to UVA. 7 patients also displayed an increased sensitivity to UVB. 13 farmers came into contact with olaquindox in mineral feed (1000 mg/kg) and only 2 in final feed (50 mg/kg). 8 patients avoided further contact with olaquindox because of warnings in the media. Allergies and photoallergies to other occupational substances preceded or followed olaquindox (photo)allergy. Because of their increased sensitivity to light, most of these farmers used sunscreens, and 2 of them developed (photo)allergy to UV-absorbers. As a result of our studies, we recommend photopatch testing for olaquindox in pig breeders with photo-distributed dermatitis. This would enable the early recognition of photoallergy to olaquindox and the prevention of persistent light reaction.
authors.affiliation: Department of Dermatology, University of Göttingen, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Schauder
authors.forename: W
authors.initials: W
authors.lastname: Schröder
authors.forename: J
authors.initials: J
authors.lastname: Geier
mesh_terms: D000328:Adult; D000368:Aged; D000382:Agricultural Workers' Diseases / Q000175:diagnosis / Q000209:etiology / Q000517:prevention & control; D000395:Air Pollutants, Occupational / Q000009:adverse effects; D000485:Allergens / Q000009:adverse effects; D000821:Animal Feed / Q000009:adverse effects*; D000818:Animals; D009783:Dermatitis, Occupational / Q000175:diagnosis / Q000209:etiology* / Q000517:prevention & control; D017454:Dermatitis, Photoallergic / Q000175:diagnosis / Q000209:etiology* / Q000517:prevention & control; D003875:Drug Eruptions; D004391:Dust; D005145:Face; D005260:Female; D006801:Humans; D008297:Male; D008397:Masks; D008875:Middle Aged; D016273:Occupational Exposure / Q000009:adverse effects; D010328:Patch Tests; D011810:Quinoxalines / Q000009:adverse effects*; D012189:Retrospective Studies; D012867:Skin / Q000187:drug effects / Q000528:radiation effects; D013473:Sunscreening Agents / Q000627:therapeutic use; D013552:Swine; D014466:Ultraviolet Rays / Q000009:adverse effects*
chemical_list: D000395:Air Pollutants, Occupational; D000485:Allergens; D004391:Dust; D011810:Quinoxalines; D013473:Sunscreening Agents; C013168:olaquindox