Phenotype of mice lacking functional Deleted in colorectal cancer (Dcc) gene.
The DCC (Deleted in colorectal cancer) gene was first identified as a candidate for a tumour-suppressor gene on human chromosome 18q. More recently, in vitro studies in rodents have provided evidence that DCC might function as a receptor for the axonal chemoattractant netrin-1. Inactivation of the murine Dcc gene caused defects in axonal projections that are similar to those observed in netrin-1-deficient mice but did not affect growth, differentiation, morphogenesis or tumorigenesis in mouse intestine. These observations fail to support a tumour-suppressor function for Dcc, but are consistent with the hypothesis that DCC is a component of a receptor for netrin-1.
Fazeli
A
A
Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Cambridge 02142, USA.
Dickinson
S L
SL
Hermiston
M L
ML
Tighe
R V
RV
Steen
R G
RG
Small
C G
CG
Stoeckli
E T
ET
Keino-Masu
K
K
Masu
M
M
Rayburn
H
H
Simons
J
J
Bronson
R T
RT
Gordon
J I
JI
Tessier-Lavigne
M
M
Weinberg
R A
RA
D000818:Animals; D001369:Axons / Q000473:pathology; D001921:Brain / Q000002:abnormalities / Q000196:embryology; D001932:Brain Neoplasms / Q000235:genetics; D015815:Cell Adhesion Molecules / Q000235:genetics / Q000502:physiology*; D002455:Cell Division; D002678:Chimera; D002874:Chromosome Mapping; D015179:Colorectal Neoplasms / Q000235:genetics; D000075389:DCC Receptor; D018390:Gene Targeting; D016163:Genes, DCC; D006801:Humans; D007413:Intestinal Mucosa / Q000473:pathology; D007414:Intestinal Neoplasms / Q000235:genetics*; D007417:Intestinal Polyps / Q000235:genetics; D051379:Mice; D008810:Mice, Inbred C57BL; D016296:Mutagenesis; D009414:Nerve Growth Factors / Q000502:physiology; D000075388:Netrin-1; D010641:Phenotype; D011956:Receptors, Cell Surface / Q000378:metabolism; D013116:Spinal Cord / Q000002:abnormalities / Q000196:embryology; D025521:Tumor Suppressor Proteins
D015815:Cell Adhesion Molecules; D000075389:DCC Receptor; C501909:DCC protein, human; C501910:Dcc protein, mouse; C000617351:NTN1 protein, human; D009414:Nerve Growth Factors; C000617353:Ntn1 protein, mouse; D011956:Receptors, Cell Surface; D025521:Tumor Suppressor Proteins; D000075388:Netrin-1