title: [Postoperative hormone therapy of breast cancer (analysis of overall survival)].
abstract: A third series of randomized evaluation of postoperative (adjuvant) hormone therapy (tamoxifen, sinestrol and orimeten) was carried out in breast cancer patients. The study group involved 1.332 reproductive and postmenopausal females with stage I-III tumors. The investigation established quite a range of 10-year survival evidence versus stage and reproductive status; however, no significant differences were recorded in either of the groups. Untoward side-effects were more frequent when treating with diethyl-stilbestrol (over 30%) than with tamoxifen (3.5%). No significant differences were registered in five-year total and recurrence-free survival in the treatment with orimeten or tamoxifen.
authors.forename: V F
authors.initials: VF
authors.lastname: Semiglazov
authors.forename: V G
authors.initials: VG
authors.lastname: Ivanov
authors.forename: O A
authors.initials: OA
authors.lastname: Ivanova
authors.forename: V M
authors.initials: VM
authors.lastname: Moiseenko
authors.forename: E V
authors.initials: EV
authors.lastname: Tsyrlina
authors.forename: N I
authors.initials: NI
authors.lastname: Barash
authors.forename: R T
authors.initials: RT
authors.lastname: Popova
authors.forename: N S
authors.initials: NS
authors.lastname: Migmanova
authors.forename: I K
authors.initials: IK
authors.lastname: Seleznev
authors.forename: A A
authors.initials: AA
authors.lastname: Bozhok
mesh_terms: D000328:Adult; D000616:Aminoglutethimide / Q000627:therapeutic use; D018931:Antineoplastic Agents, Hormonal / Q000009:adverse effects / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000401:mortality* / Q000473:pathology / Q000601:surgery; D017024:Chemotherapy, Adjuvant; D004028:Dienestrol / Q000627:therapeutic use; D004968:Estrogens, Non-Steroidal / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D016019:Survival Analysis; D013629:Tamoxifen / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D018931:Antineoplastic Agents, Hormonal; D004968:Estrogens, Non-Steroidal; D013629:Tamoxifen; D000616:Aminoglutethimide; D004028:Dienestrol