Protective effects of interleukin-11 in a murine model of ischemic bowel necrosis.
The present study examined the effect of interleukin-11 (IL-11) in a murine model of bowel ischemia (BI). Prophylactic IL-11 administration in BI mice (induced by occluding the superior mesenteric artery for 90 min) was associated with significantly decreased morbidity and mortality. IL-11-treated mice demonstrated rapid recovery of intestinal mucosa as evidenced by an increase in mitotic activity and suppression of apoptosis in intestinal crypt cells as well as increased peripheral platelet and leukocyte counts primarily due to an increase in peripheral lymphocyte number in BI mice. In contrast to vehicle-treated mice, which uniformly developed thrombocytopenia after ischemic injury, no IL-11-treated BI mice developed thrombocytopenia during the experimental period. These data suggest a role for IL-11 in the treatment of gastrointestinal mucosal diseases due to a wide variety of causative injuries.
Du
X
X
Herman B Wells Center for Pediatric Research, James Whitcomb Riley Hospital for Children, Indianapolis, Indiana 46202, USA.
Liu
Q
Q
Yang
Z
Z
Orazi
A
A
Rescorla
F J
FJ
Grosfeld
J L
JL
Williams
D A
DA
D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004761:Enterocolitis, Pseudomembranous / Q000628:therapy; D017370:Interleukin-11 / Q000494:pharmacology*; D007413:Intestinal Mucosa / Q000098:blood supply* / Q000166:cytology / Q000502:physiology; D007511:Ischemia / Q000188:drug therapy*; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D009336:Necrosis; D011994:Recombinant Proteins; D012038:Regeneration / Q000187:drug effects; D013921:Thrombocytopenia / Q000517:prevention & control
D017370:Interleukin-11; D011994:Recombinant Proteins