Anti-inflammatory activity of some novel 1-[3-(aroylo)] and one 1-[3-(aryloxy)]-propyl aminothiazole in correlation with structure and lipophilicity.
The effect of some new 1-[3-(aroylo)] and one 1-[3-[aryloxy)]-propyl aminothiazole on inflammation was investigated in the carrageenin-induced mouse paw edema (36-58% edema inhibition). In addition they exhibited significant analgesic activity (55-80.6%) in the writhing test. Their antioxidant activity in vitro using the stable free radical 1.1-diphenyl-2-picrylhydrazyl (DPPH), was determined. Antiproteolytic ability and beta-glucuronidase inhibition have been studied. The tested compounds did not inhibit soybean 12-lipoxygenase. RM values, as an expression of lipophilicity, were determined.
Hadjipavlou-Litina
D J
DJ
Department of Pharmaceutical Chemistry, School of Pharmacy, University of Thessaloniki, Greece.
Geronikaki
A A
AA
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects; D015764:Bepridil / Q000031:analogs & derivatives; D001713:Biphenyl Compounds; D002351:Carrageenan; D002855:Chromatography, Thin Layer; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D005609:Free Radicals; D005966:Glucuronidase / Q000037:antagonists & inhibitors; D008297:Male; D051379:Mice; D008806:Mice, Inbred AKR; D010851:Picrates; D013329:Structure-Activity Relationship; D013844:Thiazoles / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000975:Antioxidants; D001713:Biphenyl Compounds; D005609:Free Radicals; D010851:Picrates; D013844:Thiazoles; D015764:Bepridil; D002351:Carrageenan; C004931:1,1-diphenyl-2-picrylhydrazyl; D005966:Glucuronidase