Evidence of the involvement of biogenic amines in the antinociceptive effect of a vouacapan extracted from Pterodon polygalaeflorus Benth.
In view of the extensive use of Pterodon species in Brazilian folk medicine, the present investigation was performed to examine the involvement of biogenic amines in antinociceptive by a vouacapan (6 alpha-7 beta-dihydroxy vouacapan-17 beta-oate), extracted from seeds of Pterodon polygalaeflorus Benth), using acetic acid writhing test in mice. The alpha 2-adrenergic (yohimbine) and D2-dopaminergic (domperidone) antagonists and the pretreatment with the peripheral noradrenergic depletor, guanethidine partially inhibited the antinociceptive effect of vouacapan. Dopamine and D2 dopaminergic agonist (Ly 17155) caused antinociceptive that was not antagonized by naloxone but by domperidone, whereas noradrenaline induce pain. A synergistic analgesic effect was obtained when vouacapan was associated with clonidine or dopamine. These results indicate that vouacapan acts, at least in part, through activation of the catecholaminergic system.
Duarte
I D
ID
Departamento de Farmacologia, UFMG, Belo Horizonte, M.G., Brazil.
Ferreira-Alves
D L
DL
Veloso
D P
DP
Nakamura-Craig
M
M
D018712:Analgesics, Non-Narcotic / Q000494:pharmacology*; D000818:Animals; D001938:Brazil; D003000:Clonidine / Q000494:pharmacology; D004224:Diterpenes / Q000494:pharmacology*; D004294:Domperidone / Q000494:pharmacology; D004298:Dopamine / Q000502:physiology*; D006145:Guanethidine / Q000494:pharmacology; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology; D010946:Plants, Medicinal; D015016:Yohimbine / Q000494:pharmacology
D018712:Analgesics, Non-Narcotic; D004224:Diterpenes; D010936:Plant Extracts; D015016:Yohimbine; C073437:vouacapan; D004294:Domperidone; D003000:Clonidine; D004298:Dopamine; D006145:Guanethidine