title: Modulation of lipoxygenase activity by bacterial hopanoids.
abstract: Tetrahydroxybacteriohopane (1), a bacterial hopanoid, inhibited soybean 15-lipoxygenase with an IC50 of about 10 microM. After per-O-acetylation of 1 no inhibition of the 15-lipoxygenase was observed. Two other bacterial hopanoids, tetrahydroxybacteriohopane glucosamine (2) and tetrahydroxybacteriohopane ether (3), stimulated the activity of soybean 15-lipoxygenase. The activities of two other arachidonic acid-metabolizing enzymes, human 5-lipoxygenase and prostaglandin H synthase, were unaffected by 1.
authors.affiliation: Eastern Regional Research Center, U.S. Department of Agriculture, Wyndmoor, Pennsylvania 19038, USA. rmoreau@arserrc.gov
authors.forename: R A
authors.initials: RA
authors.lastname: Moreau
authors.forename: J
authors.initials: J
authors.lastname: Agnew
authors.forename: K B
authors.initials: KB
authors.lastname: Hicks
authors.forename: M J
authors.initials: MJ
authors.lastname: Powell
mesh_terms: D001094:Arachidonate 5-Lipoxygenase / Q000378:metabolism; D006801:Humans; D016859:Lipoxygenase Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism; D011994:Recombinant Proteins / Q000737:chemistry; D013025:Glycine max / Q000201:enzymology; D014315:Triterpenes / Q000302:isolation & purification* / Q000494:pharmacology; D017355:Zymomonas / Q000737:chemistry
chemical_list: D016859:Lipoxygenase Inhibitors; D011994:Recombinant Proteins; D014315:Triterpenes; C054760:32,33,34,35-bacteriohopanetetrol; D001094:Arachidonate 5-Lipoxygenase; D011451:Prostaglandin-Endoperoxide Synthases