Induction of lymphocyte apoptosis by a novel immunosuppressant FTY720: relation with Fas, Bcl-2 and Bax expression.
Li
X K
XK
Department of Experimental Surgery & Bioengineering, National Children's Medical Research Center, Tokyo, Japan.
Shinomiya
T
T
Enosawa
S
S
Kakefuda
T
T
Amemiya
H
H
Suzuki
S
S
D000284:Administration, Oral; D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D002478:Cells, Cultured; D000068876:Fingolimod Hydrochloride; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000494:pharmacology*; D019169:Jurkat Cells; D007700:Kinetics; D008214:Lymphocytes / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D008817:Mice, Mutant Strains; D011409:Propylene Glycols / Q000008:administration & dosage / Q000494:pharmacology*; D011518:Proto-Oncogene Proteins / Q000096:biosynthesis*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000096:biosynthesis*; D013110:Sphingosine / Q000031:analogs & derivatives; D013601:T-Lymphocytes / Q000166:cytology / Q000187:drug effects / Q000502:physiology; D051028:bcl-2-Associated X Protein; D019014:fas Receptor / Q000096:biosynthesis*
C494826:BAX protein, human; C494827:Bax protein, mouse; D007166:Immunosuppressive Agents; D011409:Propylene Glycols; D011518:Proto-Oncogene Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D051028:bcl-2-Associated X Protein; D019014:fas Receptor; D000068876:Fingolimod Hydrochloride; D013110:Sphingosine