Castanospermine, an oligosaccharide-processing inhibitor, reduces membrane expression of adhesion molecules and prolongs heart allograft survival in rats.
Hibberd
A D
AD
Newcastle Transplant Unit, Department of Surgery, John Hunter Hospital, New Lambton, New South Wales, Australia.
Grochowicz
P M
PM
Smart
Y C
YC
Bowen
K M
KM
Clark
D A
DA
Cowden
W B
WB
Willenborg
D O
DO
D000818:Animals; D000945:Antigens, Differentiation, T-Lymphocyte / Q000096:biosynthesis; D006085:Graft Survival / Q000187:drug effects*; D016027:Heart Transplantation / Q000276:immunology*; D015395:Histocompatibility Antigens Class I / Q000096:biosynthesis; D000949:Histocompatibility Antigens Class II / Q000096:biosynthesis; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D007212:Indolizines / Q000627:therapeutic use*; D018799:Intercellular Adhesion Molecule-1 / Q000096:biosynthesis*; D016169:Lymphocyte Function-Associated Antigen-1 / Q000096:biosynthesis*; D008221:Lymphoid Tissue / Q000187:drug effects / Q000276:immunology; D051381:Rats; D011914:Rats, Inbred BN; D011917:Rats, Inbred Lew; D011919:Rats, Inbred Strains; D014184:Transplantation, Homologous; D054836:Indolizidines
D000945:Antigens, Differentiation, T-Lymphocyte; D015395:Histocompatibility Antigens Class I; D000949:Histocompatibility Antigens Class II; D007166:Immunosuppressive Agents; D007212:Indolizines; D018799:Intercellular Adhesion Molecule-1; D016169:Lymphocyte Function-Associated Antigen-1; C037806:castanospermine; D054836:Indolizidines