Low dose angiotensin II infusions into the renal artery induce chronic hypertension in conscious dogs.
Angiotensin II was infused at 0.5 ng/kg/min either directly into the left renal artery (n = 5) or intravenously (n = 4) for 28 days in conscious dogs. Renal artery infusion of angiotensin II had no significant effect on mean arterial pressure after 1 and 24 h, but pressure had increased by 12 +/- 2, 12 +/- 4, 8 +/- 3 and 13 +/- 3 mmHg on days 7, 14, 21 and 28, respectively, during infusion. Renal blood flow decreased significantly at 24 hours (p = 0.02) but was not significantly reduced subsequently. Over days 7-28, central venous pressure and haematocrit rose significantly but body weight did not change significantly. During intravenous infusion of angiotensin II, arterial pressure increased (5 +/- 4, 7 +/- 5 and 5 +/- 3 mmHg on days 7, 14 and 21, respectively), body weight rose and haematocrit fell significantly, but central venous pressure did not change. Thus, angiotensin II infused into the renal artery, at a dose which had no initial pressor effect, produced chronic, stable hypertension, with equivocal evidence of renal fluid retention. We conclude that elevated levels of angiotensin II in the kidney alone can cause chronic hypertension.
Fitzgerald
S M
SM
Emily E.E. Stewart Renal Laboratory, Baker Medical Research Institute, Melbourne, Australia.
Stevenson
K M
KM
Evans
R G
RG
Anderson
W P
WP
D000804:Angiotensin II / Q000633:toxicity*; D000818:Animals; D002908:Chronic Disease; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D006977:Hypertension, Renal / Q000139:chemically induced*; D007261:Infusions, Intra-Arterial; D007262:Infusions, Intravenous; D010865:Pilot Projects; D012077:Renal Artery; D012079:Renal Circulation / Q000187:drug effects*; D012965:Sodium Chloride / Q000378:metabolism; D014655:Vascular Resistance / Q000187:drug effects; D014662:Vasoconstrictor Agents / Q000633:toxicity*; D014867:Water / Q000378:metabolism
D014662:Vasoconstrictor Agents; D014867:Water; D000804:Angiotensin II; D012965:Sodium Chloride