title: Initial experience with collagen-filled Guglielmi detachable coils for endovascular treatment of experimental aneurysms.
abstract: OBJECTIVE
  To evaluate the effectiveness of Guglielmi detachable coils (GDCs) filled with collagen threads in the permanent treatment of experimental aneurysms.
  
  
  METHODS
  Seventeen side-wall aneurysms were surgically constructed in the canine common carotid artery; six were treated with conventional GDCs and 11 with collagen-filled GDCs. One aneurysms was removed at 1 week, the others were studied by digital subtraction angiography for a period of 8 to 12 weeks. Longitudinal sections of all aneurysms were examined by light microscopy.
  
  
  RESULTS
  Angiograms obtained throughout the follow-up period showed no significant difference between aneurysms treated with conventional GDCs and those treated with collagen-filled GDCs. Light microscopy revealed a dense meshwork of newly formed collagen and fibroblasts near the collagen-filled GDCs, whereas a loose cellular meshwork surrounded the conventional GDCs at 8 and 12 weeks after treatment.
  
  
  CONCLUSIONS
  Collagen threads within GDCs do not noticeably improve angiographic treatment of experimental aneurysms; however, these threads did induce local proliferation of fibroblasts and production of collagen within the aneurysmal cavities.
authors.affiliation: Stroke Research Institute, Department of Neurosurgery, State University of New York at Buffalo, School of Medicine and Biomedical Sciences 14209, USA.
authors.forename: I
authors.initials: I
authors.lastname: Szikora
authors.forename: A K
authors.initials: AK
authors.lastname: Wakhloo
authors.forename: L R
authors.initials: LR
authors.lastname: Guterman
authors.forename: T D
authors.initials: TD
authors.lastname: Chavis
authors.forename: R C
authors.initials: RC
authors.lastname: Dawson
authors.forename: R W
authors.initials: RW
authors.lastname: Hergenrother
authors.forename: R H
authors.initials: RH
authors.lastname: Twyford
authors.forename: L N
authors.initials: LN
authors.lastname: Hopkins
mesh_terms: D000783:Aneurysm / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy*; D015901:Angiography, Digital Subtraction; D000818:Animals; D002340:Carotid Artery Diseases / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy*; D017536:Carotid Artery, Common / Q000000981:diagnostic imaging / Q000473:pathology; D003094:Collagen / Q000737:chemistry; D003287:Contrast Media; D004285:Dogs; D004621:Embolization, Therapeutic / Q000295:instrumentation*; D004867:Equipment Design; D005347:Fibroblasts / Q000473:pathology; D005500:Follow-Up Studies; D013499:Surface Properties; D014654:Vascular Patency
chemical_list: D003287:Contrast Media; D003094:Collagen