title: Gene locus for autosomal recessive distal myopathy with rimmed vacuoles maps to chromosome 9.
abstract: Distal myopathy with rimmed vacuoles is an autosomal recessive muscular disorder, characterized clinically by weakness of the distal muscles in the lower limbs in early adulthood. Recently, the gene locus for familial vacuolar myopathy with autosomal recessive inheritance (hereditary inclusion body myopathy) was mapped to chromosome 9 by genome-wide linkage analysis of nine Persian-Jewish families. Since both disease conditions share similar clinical, genetic, and histopathological features, we analyzed seven families with distal myopathy with rimmed vacuoles using ten microsatellite markers within the region of the hereditary inclusion body myopathy locus. Significantly high cumulative pairwise lod scores were obtained with three markers: D9S248 (Z(max) = 5.90 at theta = 0), D9S43 (Z(max) = 5.25 at theta = 0), and D9S50 (Z(max) = 4.23 at theta = 0). Detection of obligate recombination events as well as multipoint linkage analysis revealed that the most likely location of the distal myopathy with rimmed vacuoles gene is in a 23.3-cM interval defined by D9S319 and D9S276 on chromosome 9. The results raise the possibility that distal myopathy with rimmed vacuoles and hereditary inclusion body myopathy in Persian Jews are allelic diseases.
authors.affiliation: Department of Neurology, Niigata University, Asahimachi, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Ikeuchi
authors.forename: T
authors.initials: T
authors.lastname: Asaka
authors.forename: M
authors.initials: M
authors.lastname: Saito
authors.forename: H
authors.initials: H
authors.lastname: Tanaka
authors.forename: S
authors.initials: S
authors.lastname: Higuchi
authors.forename: K
authors.initials: K
authors.lastname: Tanaka
authors.forename: K
authors.initials: K
authors.lastname: Saida
authors.forename: E
authors.initials: E
authors.lastname: Uyama
authors.forename: H
authors.initials: H
authors.lastname: Mizusawa
authors.forename: N
authors.initials: N
authors.lastname: Fukuhara
authors.forename: I
authors.initials: I
authors.lastname: Nonaka
authors.forename: M
authors.initials: M
authors.lastname: Takamori
authors.forename: S
authors.initials: S
authors.lastname: Tsuji
mesh_terms: D000328:Adult; D016009:Chi-Square Distribution; D002874:Chromosome Mapping; D002899:Chromosomes, Human, Pair 9; D005260:Female; D005808:Genes, Recessive; D008040:Genetic Linkage; D005819:Genetic Markers; D005838:Genotype; D006801:Humans; D008126:Lod Score; D008297:Male; D008875:Middle Aged; D018908:Muscle Weakness / Q000235:genetics*; D010375:Pedigree; D014617:Vacuoles
chemical_list: D005819:Genetic Markers