title: Urinary nitrite/nitrate excretion in infancy: comparison between term and preterm infants.
abstract: We measured urinary nitrite/nitrate (NOx-) excretion, an index of endogenous nitric oxide formation, in term and preterm infants aged 1 week and 1, 4, 7 months. In normal term infants, urinary NOx excretion increased from 1 week to 1 month and then decreased until 4 months where it stabilized thereafter. Urinary NOx- excretion in preterm infants was significantly higher compared with term infants at 1 week of age. This finding suggests that the nitric oxide pathway in preterm infants may be activated compared with term infants in early life. With the reference values obtained in this study, this urinary marker can now be used for identifying infants with abnormal nitric oxide production.
authors.affiliation: Department of Pediatrics, Fukui Medical School, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Tsukahara
authors.forename: M
authors.initials: M
authors.lastname: Hiraoka
authors.forename: C
authors.initials: C
authors.lastname: Hori
authors.forename: S
authors.initials: S
authors.lastname: Tsuchida
authors.forename: I
authors.initials: I
authors.lastname: Hata
authors.forename: K
authors.initials: K
authors.lastname: Nishida
authors.forename: K
authors.initials: K
authors.lastname: Kikuchi
authors.forename: M
authors.initials: M
authors.lastname: Sudo
mesh_terms: D000375:Aging; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D009566:Nitrates / Q000652:urine*; D009569:Nitric Oxide / Q000378:metabolism; D009573:Nitrites / Q000652:urine*; D012016:Reference Values
chemical_list: D009566:Nitrates; D009573:Nitrites; D009569:Nitric Oxide