title: Effect of intravenous fenoldopam on intraocular pressure in ocular hypertension.
abstract: Intravenous fenoldopam, a selective dopamine-1 receptor agonist, was compared with placebo in this randomized, double-blind, two-period crossover study to evaluate its effects on intraocular pressure, aqueous dynamics, and macular blood flow in patients with elevated intraocular pressure or primary open-angle glaucoma. Doses of fenoldopam were titrated up to a maximum of 0.5 microgram/kg/min. Intraocular pressure, measured by pneumotonometry, was the primary outcome variable. Other outcomes included macular blood flow assessed by blue field examination, visual field examined by automated perimetry, aqueous outflow facility measured by tonography, and aqueous humor production determined by fluorophotometry. During infusions of fenoldopam, intraocular pressure increased from a mean baseline level of 29.2 mmHg to a mean maximum level of 35.7 mmHg. During the placebo infusions, pressure increased from a mean baseline of 28.4 mmHg to a mean of 29.0 mmHg at the time point that corresponded to the mean maximum intraocular pressure on the day intravenous fenoldopam was administered, to yield a mean difference in pressure between study days of 6.7 mmHg (P < 0.05). There were no apparent changes in macular blood flow, visual fields, or production or outflow of aqueous humor associated with fenoldopam infusion. The increase in intraocular pressure seen in this population of patients with ocular hypertension during infusions of fenoldopam is consistent with fenoldopam-associated increases in intraocular pressure reported in previous studies of healthy volunteers and of patients with accelerated systemic hypertension. These results further suggest that dopamine-1 receptors play a role in the regulation of intraocular pressure.
authors.affiliation: SmithKline Beecham Clinical Research Unit, Presbyterian Medical Center, Philadelphia, PA 19104, USA.
authors.forename: D E
authors.initials: DE
authors.lastname: Everitt
authors.forename: S C
authors.initials: SC
authors.lastname: Boike
authors.forename: J R
authors.initials: JR
authors.lastname: Piltz-Seymour
authors.forename: R
authors.initials: R
authors.lastname: VanCoevorden
authors.forename: P
authors.initials: P
authors.lastname: Audet
authors.forename: N
authors.initials: N
authors.lastname: Zariffa
authors.forename: D
authors.initials: D
authors.lastname: Jorkasky
mesh_terms: D000328:Adult; D000368:Aged; D018592:Cross-Over Studies; D004311:Double-Blind Method; D005260:Female; D018818:Fenoldopam / Q000009:adverse effects / Q000627:therapeutic use*; D005902:Glaucoma, Open-Angle / Q000188:drug therapy; D006261:Headache / Q000139:chemically induced; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D009798:Ocular Hypertension / Q000188:drug therapy*; D012171:Retinal Vessels / Q000187:drug effects; D014665:Vasodilator Agents / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D014665:Vasodilator Agents; D018818:Fenoldopam