Interactions of platelets and endothelial cells with erythrocytes and leukocytes in thrombotic thrombocytopenic purpura.
In both normal and abnormal vascular biology, platelet-leukocyte-RBC-EC adhesive and functional interactions appear to play a significant role. The clinical hallmarks of the TTP/HUS syndromes, including prominent platelet aggregation and thrombi without prominent soluble coagulation system activation along with microangiopathic hemolysis, suggest that such interactions may help to bring a common theme of explanation to this disorder. However, a final unifying physiological pathway remains elusive.
Smith
B R
BR
Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT 06520-8035, USA.
Rinder
H M
HM
D001792:Blood Platelets / Q000166:cytology*; D002450:Cell Communication / Q000502:physiology; D004730:Endothelium, Vascular / Q000166:cytology*; D004912:Erythrocytes / Q000166:cytology; D006801:Humans; D007962:Leukocytes / Q000166:cytology; D011697:Purpura, Thrombotic Thrombocytopenic / Q000097:blood* / Q000473:pathology