title: A method for assessing catheter patency in implanted pumps for long-term intraperitoneal insulin delivery.
abstract: Catheter complications are a common problem during long-term insulin therapy with implanted pumps. The purpose of this study was to test the feasibility of imaging intraperitoneal catheters with technetium (Tc) 99m in implantable devices for insulin delivery. Testing physical stability of an insulin/Tc 99 mixture did not show formation of insulin aggregates during a period up to 48 h on a rotating wheel. Five hundred microCurie (equal to 18 MBq) of Tc 99m were injected in the flush port of a pump for intraperitoneal insulin delivery implanted in patients with type I (insulin dependent) diabetes mellitus, and gamma camera images were obtained for 30 min. In patent catheters the tracer rapidly imaged the whole length of the catheter while in occluded catheters the tracer remained in the flush port, imaging only the portion of the catheter before the occlusion. In patent catheters in which insulin absorption was impaired, the tracer rapidly imaged the whole length of the catheter, but its removal from the peritoneum was delayed. Tc 99m imaging of intraperitoneal catheters for insulin delivery can be used to assess catheter patency and impaired delivery into the peritoneal cavity.
authors.affiliation: Department of Medicine, Istituto Scientifico H San Raffaele, Milano, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Scavini
authors.forename: B
authors.initials: B
authors.lastname: Hammarberg
authors.forename: F
authors.initials: F
authors.lastname: Dosio
authors.forename: M
authors.initials: M
authors.lastname: Torri
authors.forename: G
authors.initials: G
authors.lastname: Petrella
authors.forename: G
authors.initials: G
authors.lastname: Galimberti
authors.forename: S
authors.initials: S
authors.lastname: Vai
authors.forename: F
authors.initials: F
authors.lastname: Fazio
authors.forename: G
authors.initials: G
authors.lastname: Pozza
mesh_terms: D002404:Catheterization / Q000592:standards*; D003922:Diabetes Mellitus, Type 1 / Q000188:drug therapy*; D016503:Drug Delivery Systems; D005240:Feasibility Studies; D005260:Female; D005720:Gamma Rays; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage* / Q000378:metabolism / Q000627:therapeutic use; D015918:Infusion Pumps, Implantable / Q000592:standards*; D007263:Infusions, Parenteral; D007328:Insulin / Q000008:administration & dosage* / Q000378:metabolism / Q000627:therapeutic use; D007553:Isotope Labeling; D008297:Male; D013667:Technetium
chemical_list: D007004:Hypoglycemic Agents; D007328:Insulin; D013667:Technetium