title: A study of the effect of isoflurane anaesthesia on equine skeletal muscle perfusion.
abstract: The effects of 1.1, 1.5 and 1.8 MAC (minimum alveolar concentration) isoflurane-02 anaesthesia on skeletal muscle blood flow, 02 delivery and vascular resistance were studied in the non-dependent region of seven healthy normothermic, isocapnoeic ponies. Muscle blood flow was determined with 15 microns diameter radionuclide labelled microspheres that were injected into the left ventricle. Muscle blood flow during anaesthesia was compared to unanaesthetised (control) measurements. Isoflurane administration caused a dose dependent decrease in mean aortic pressure, and skeletal muscle (temporalis, triceps brachii, longissimus dorsi, gluteus medius, biceps femoris, vastus lateralis) blood flow. However, in the masseter, triceps brachii at 1.1 and 1.5 MAC, and longissimus dorsi lumborum at 1.1 MAC anaesthesia, blood flow values were not different from the control value. Vascular resistance did not change significantly in any of the muscles with any concentration of isoflurane. With the exception of the masseter muscle, isoflurane anaesthesia also decreased skeletal muscle 02 delivery. There were no significant differences in the muscle parameters studied between the three concentrations of isoflurane. Because skeletal muscle vascular resistance was unchanged throughout the study, it is possible that there may be an interference of 'autoregulation' in the skeletal muscle vascular beds of isocapnoeic ponies during isoflurane-02 anaesthesia.
authors.affiliation: Department of Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois, Urbana, USA.
authors.forename: T E
authors.initials: TE
authors.lastname: Goetz
authors.forename: M
authors.initials: M
authors.lastname: Manohar
authors.forename: D
authors.initials: D
authors.lastname: Nganwa
authors.forename: R
authors.initials: R
authors.lastname: Gustafson
mesh_terms: D018685:Anesthetics, Inhalation / Q000494:pharmacology*; D000818:Animals; D001784:Blood Gas Analysis / Q000662:veterinary; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D006439:Hemodynamics / Q000187:drug effects / Q000502:physiology; D006454:Hemoglobins / Q000032:analysis; D006736:Horses / Q000502:physiology*; D007530:Isoflurane / Q000494:pharmacology*; D008863:Microspheres; D018482:Muscle, Skeletal / Q000098:blood supply / Q000187:drug effects* / Q000502:physiology; D010100:Oxygen / Q000032:analysis; D012039:Regional Blood Flow / Q000187:drug effects / Q000502:physiology; D014655:Vascular Resistance / Q000187:drug effects / Q000502:physiology
chemical_list: D018685:Anesthetics, Inhalation; D006454:Hemoglobins; D007530:Isoflurane; D010100:Oxygen