Oxidative phosphorylation and F(O)F(1) ATP synthase activity of human hepatocellular carcinoma.
A study of mitochondrial oxidative phosphorylation in biopsies from human hepatocellular carcinoma is presented. Tumour mitochondria as compared to control liver mitochondria, besides a reduced activity of complex IV (cytochrome c oxidase) of the respiratory chain, show a decreased phosphorylative capacity. This appears to be mainly related to a defective F o F(1) ATP synthase complex. Use of an antibody against the F(1) portion of the complex demonstrate a definite decrease for the beta subunit of F(1) in tumour mitochondria.
Capuano
F
F
Institute of Medical Biochemistry and Chemistry, University of Bari, Italy.
Varone
D
D
D'Eri
N
N
Russo
E
E
Tommasi
S
S
Montemurro
S
S
Prete
F
F
Papa
S
S
D000251:Adenosine Triphosphatases / Q000378:metabolism*; D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000378:metabolism*; D003576:Electron Transport Complex IV / Q000378:metabolism*; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D008930:Mitochondria, Liver / Q000378:metabolism*; D010085:Oxidative Phosphorylation
D003576:Electron Transport Complex IV; D000251:Adenosine Triphosphatases