[Simvastatin and pregnancy].
This study concerns 169 women whose exposure to simvastatin (Zocor or Lodales) during pregnancy led to a request for information from pharmaceutical firms. The evolution of pregnancies (among which 2 were twins) was documented in 125 women: 66 women gave birth to normal babies, 40 requested and induced abortion, 12 spontaneous abortions occurred, and the 9 other known pregnancy issues were 4 premature newborns, 3 newborns with malformations and 2 fetal deaths. Apart from the 5 retrospective files concerning 5 spontaneous abortions, all the files were analysed prospectively. Except for induced abortions, regarding the prospective files, the pregnancy outcome was comparable with that of a general population.
Freyssinges
C
C
Laboratoires MSD-Chibret, Paris.
Ducrocq
M B
MB
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000924:Anticholesteremic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000188:drug therapy; D008148:Lovastatin / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D008875:Middle Aged; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy*; D019821:Simvastatin
D000924:Anticholesteremic Agents; D008148:Lovastatin; D019821:Simvastatin