title: The transverse magnetisation decay characteristics of longstanding lesions and normal-appearing white matter in multiple sclerosis.
abstract: The characteristics of transverse magnetisation decay of 120 longstanding lesions and 40 regions of normal-appearing white matter have been analysed in 40 patients with multiple sclerosis (MS) and 10 normal controls. Fifty lesions showed a biexponential decay in which two water compartments-one probably intracellular, the other extracellular-could be defined. There was a higher frequency of biexponential lesions in patients with a primary progressive course but no significant difference between benign and secondary progressive groups. Seventy lesions showed a monoexponential decay, of which 31 showed a T2 of greater than 200 ms, implying that these lesions were predominantly composed of extracellular rather than intracellular water. The results imply that an expanded extracellular space within chronic MS brain lesions is a common finding at all levels of disability and disease course. In so far as an expanded extracellular space implies axonal loss, the results suggest that the latter occurs commonly in longstanding MS lesions. The lack of correlation with disability suggests a limited role for the technique in therapeutic monitoring.
authors.affiliation: NMR Research Unit, National Hospital for Neurology and Neurosurgery, London, UK.
authors.forename: D
authors.initials: D
authors.lastname: Kidd
authors.forename: G J
authors.initials: GJ
authors.lastname: Barker
authors.forename: P S
authors.initials: PS
authors.lastname: Tofts
authors.forename: A
authors.initials: A
authors.lastname: Gass
authors.forename: A J
authors.initials: AJ
authors.lastname: Thompson
authors.forename: W I
authors.initials: WI
authors.lastname: McDonald
authors.forename: D H
authors.initials: DH
authors.lastname: Miller
mesh_terms: D000328:Adult; D001369:Axons / Q000473:pathology; D002540:Cerebral Cortex / Q000473:pathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000175:diagnosis*