title: Parental occupational exposure and the risk of testicular cancer in Ontario.
abstract: The incidence of germ cell testicular cancer is increasing, but its etiology remains largely unknown. Initiation may occur in a parental germ cell. In a case-control study in Ontario, jobs and industries of mothers (before and during pregnancy) and fathers (before pregnancy) of 343 case subjects and 524 control subjects were analyzed. Significantly increased risk was associated with fathers who were wood processors (odds ratio [OR] = 10.46; 95% confidence interval [CI], 1.20 to 91.14), metalworkers (OR = 3.28; 95% CI, 1.03 to 10.52), stationary engineers (OR = 1.05; 95% CI, 1.05 to 11.87), or employees of the food products (OR = 2.79; 95% CI, 1.34 to 5.79), metal products (OR = 5.77, 95% CI, 1.53 to 21.77), or food and beverage services (OR = 4.36; 95% CI, 1.50 to 12.63) industries. There was little evidence of risk associated with maternal employment. Paternal employment before conception in jobs related particularly to metal or food and beverages may be related to testicular cancer risk in sons.
authors.affiliation: Division of Preventive Oncology, Ontario Cancer Treatment and Research Foundation, Toronto, Canada.
authors.forename: J A
authors.initials: JA
authors.lastname: Knight
authors.forename: L D
authors.initials: LD
authors.lastname: Marrett
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D005260:Female; D018237:Germinoma / Q000453:epidemiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure / Q000009:adverse effects*; D009864:Ontario / Q000453:epidemiology; D018812:Paternal Exposure / Q000009:adverse effects*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D013736:Testicular Neoplasms / Q000453:epidemiology*