Ganglioside alterations in the central and peripheral nervous systems of patients with Creutzfeldt-Jakob disease.
We have examined the distribution and composition of gangliosides in central and peripheral nervous tissues from two patients with Creutzfeldt-Jakob disease (CJD). There were marked decreases in total ganglioside levels in CJD, with reductions in the cerebral cortex and cerebellum in the order of 20-30% and 50% of control values, respectively, though in spinal cord and sciatic nerve total gangliosides were not significantly altered. The percentage distribution of individual gangliosides was characterized by marked increases in GD3 and GD2, contrasting with severe decreases in GD1a, GD1b, GT1b and GQ1b; such changes were found throughout the patients' nervous tissues. An abnormal long-chain base composition was detected with the d20:1 component being decreased to less than 50% of control values, in the cerebrum, cerebellum and spinal cord. Changes in gangliosides occurred even in those tissues not severely affected neuropathologically. These ganglioside abnormalities are discussed in relationship to the pathogenesis of CJD.
Ohtani
Y
Y
Department of Psychiatry, School of Medicine, Kitasato University, Kanagawa, Japan.
Tamai
Y
Y
Ohnuki
Y
Y
Miura
S
S
D000368:Aged; D002490:Central Nervous System / Q000378:metabolism*; D002855:Chromatography, Thin Layer; D007562:Creutzfeldt-Jakob Syndrome / Q000378:metabolism*; D005260:Female; D005732:Gangliosides / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010525:Peripheral Nerves / Q000378:metabolism*; D012016:Reference Values
D005732:Gangliosides