title: Evaluation of major parotid glycoproteins in patients with burning mouth syndrome.
abstract: OBJECTIVE
  This study was to investigate the potential role of salivary glycoproteins in burning mouth syndrome.
  
  
  METHODS
  This study compared major parotid glycoproteins in a group of patients with burning mouth syndrome and age-, sex-, race-matched healthy controls.
  
  
  RESULTS
  By use of a glycoprotein detection kit, saliva from both patients and controls exhibited three major parotid glycoprotein banding patterns consisting of either one or two bands, molecular weights 58 kDa and 77 kDa. The strong lectin reactivity of major parotid glycoproteins with Ricinus communis agglutinin suggests that galactose is the most prevalent terminal sugar. In addition, major parotid glycoproteins were shown to express blood group antigen H. On the basis of metachromatic characteristics and immunologic reactivity, major parotid glycoproteins appear to be members of the proline rich protein multigene family, proline rich glycoprotein, genetic polymorphism G1. No qualitative difference was observed in major parotid glycoprotein banding patterns between patients and controls.
  
  
  CONCLUSIONS
  These findings do not support a role for major parotid glycoproteins in burning mouth syndrome.
authors.affiliation: School of Clinical Dentistry, The Queen's University of Belfast, U.K.
authors.forename: F T
authors.initials: FT
authors.lastname: Lundy
authors.forename: I
authors.initials: I
authors.lastname: Al-Hashimi
authors.forename: T D
authors.initials: TD
authors.lastname: Rees
authors.forename: P J
authors.initials: PJ
authors.lastname: Lamey
mesh_terms: D000017:ABO Blood-Group System / Q000032:analysis; D002054:Burning Mouth Syndrome / Q000378:metabolism*; D016022:Case-Control Studies; D004591:Electrophoresis, Polyacrylamide Gel; D005260:Female; D005690:Galactose / Q000032:analysis; D006023:Glycoproteins / Q000032:analysis*; D006031:Glycosylation; D006801:Humans; D008297:Male; D008875:Middle Aged; D008970:Molecular Weight; D010306:Parotid Gland / Q000378:metabolism; D010455:Peptides / Q000032:analysis; D055232:Proline-Rich Protein Domains; D012471:Salivary Proteins and Peptides / Q000032:analysis*
chemical_list: D000017:ABO Blood-Group System; D006023:Glycoproteins; D010455:Peptides; D012471:Salivary Proteins and Peptides; D005690:Galactose