Abrupt cessation of immunosuppression in a patient with persistent acute lymphoblastic leukaemia following allogeneic transplantation.
A 20-year-old man with acute lymphoblastic leukaemia (ALL) in second complete remission underwent sibling donor transplant. Post-transplant there was haematological and immunophenotypic evidence of persisting disease. Cyclosporine was abruptly discontinued and following this the leukaemic clone disappeared. Discontinuation of immunosuppression may be of benefit in leukaemia which persists following transplant.
Rymes
N L
NL
Department of Haematology, Queen Elizabeth Hospital, Birmingham, UK.
Murray
J A
JA
Holmes
J A
JA
D000328:Adult; D016026:Bone Marrow Transplantation; D006086:Graft vs Host Disease; D006801:Humans; D007165:Immunosuppression Therapy; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000276:immunology / Q000473:pathology / Q000628:therapy; D014184:Transplantation, Homologous