Synthesis of a new potent anti-angiogenic agent, 17 alpha-acetoxy-9 alpha-fluoro-6 alpha-methylprogesterone (9 alpha-fluoromedroxyprogesterone acetate [FMPA]).
A new anti-angiogenic agent, 17 alpha-acetoxy-9 alpha-fluoro-6 alpha-methylprogesterone (9 alpha-fluoromedoroxyprogesterone acetate [FMPA, 9] was synthetized in a 10-step sequence. FMPA (9) had about two orders of magnitude stronger anti-angiogenic activity than medroxyprogesterone acetate (MPA), as estimated in a bioassay involving chorioallantoic membranes of growing chick embryos.
Sugino
E
E
Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, Hiroshima, Japan.
Fujimori
S
S
Hibino
S
S
Choshi
T
T
Ichihara
Y
Y
Sato
Y
Y
Yamaji
T
T
Tsuboi
H
H
Murata
N
N
Uchida
M
M
Shimamura
M
M
Oikawa
T
T
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002642:Chick Embryo; D017258:Medroxyprogesterone Acetate / Q000494:pharmacology; D018919:Neovascularization, Physiologic / Q000187:drug effects*; D011374:Progesterone / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology
C105228:17-acetoxy-9-fluoro-6-methylprogesterone; D000970:Antineoplastic Agents; D011374:Progesterone; D017258:Medroxyprogesterone Acetate