Idiopathic thrombocytopenic purpura following allogeneic bone marrow transplantation--treatment with anti-D immunoglobulin.
A 38-year-old man developed idiopathic thrombocytopenic purpura (ITP) 8 months following allogeneic BMT while being treated for cGVHD with corticosteroids and tacrolimus (FK506). He received two courses of high-dose intravenous immunoglobulin (IvIG) which resulted in transient improvement. A single dose of intravenous anti-D immunoglobulin induced a durable response. Anti-D immunoglobulin is better tolerated, less complicated to administer, and less expensive than a course of IvIG.
Lee
S J
SJ
Brigham and Women's Hospital, Department of Medicine, Boston, MA 02115, USA.
Churchill
W H
WH
Konugres
A
A
Gilliland
D G
DG
Antin
J H
JH
D000328:Adult; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000188:drug therapy / Q000209:etiology; D018029:Rho(D) Immune Globulin / Q000008:administration & dosage*; D014184:Transplantation, Homologous
D018029:Rho(D) Immune Globulin