title: The familial aggregation of depressive symptoms, antisocial behavior, and alcohol abuse.
abstract: This study describes results from an ongoing family study of adolescent boys and their families designed to investigate potential risk factors for substance abuse. The adolescent treatment probands have severe drug and alcohol related problems and were recruited through a residential rehabilitation program. To date, the sample includes 251 individuals: 39 male probands and their families and 34 control families matched for age and geographic location (zip code). Probands and participating family members are given a structured interview which assesses alcohol and drug problems, and various psychiatric symptoms. The purpose of the present study was to examine the coaggregation of depressive symptoms, antisocial behavior, and alcohol misuse. Multivariate pedigree analyses were performed using a model that allowed for the estimation of vertical familial transmission, residual sibling resemblance, and assortative mating. Spouse correlations were estimated at .57, .21, and .31 for antisocial behavior, depressive symptoms, and alcohol abuse, respectively. Residual sibling environment (i.e., sibling resemblance unaccounted for by parent-offspring transmission) was not found for alcohol problem symptoms, but did contribute to resemblance for antisocial behavior and depressive symptoms. The proportion of variance accounted for by vertical familial transmission was estimated at approximately 30 to 40%. More important, correlations among the transmissible family factors for these psychiatric syndromes ranged from .58 to .73, suggesting substantial overlap among the underlying familial antecedents for these disorders.
authors.affiliation: Institute for Behavioral Genetics, University of Colorado, Boulder 80309-0447, USA. Michael.Stallings@Colorado.EDU
authors.forename: M C
authors.initials: MC
authors.lastname: Stallings
authors.forename: S S
authors.initials: SS
authors.lastname: Cherny
authors.forename: S E
authors.initials: SE
authors.lastname: Young
authors.forename: D R
authors.initials: DR
authors.lastname: Miles
authors.forename: J K
authors.initials: JK
authors.lastname: Hewitt
authors.forename: D W
authors.initials: DW
authors.lastname: Fulker
mesh_terms: D000293:Adolescent; D000294:Adolescent Behavior; D000437:Alcoholism / Q000235:genetics*; D000987:Antisocial Personality Disorder / Q000235:genetics*; D003866:Depressive Disorder / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D008957:Models, Genetic; D010375:Pedigree; D010641:Phenotype