title: Treatment of pathologic fracture and surgical value of prognostic factors in multiple myeloma.
abstract: Fifty-eight cases diagnosed as multiple myeloma were reviewed to assess the surgical treatment and prognostic factors which had been recently advocated to predict the survival. The following data in these cases were investigated: age, sex, surgical modalities and prognostic factors such as beta 2-microglobulin, LDH, hemoglobin, etc. In our study, surgical significance based on these laboratory findings was discussed. There was significant difference (p < 0.05) in hemoglobin level between pathologic fracture group and non-fracture group. The albumin in the fracture group was lower than the albumin in the non-fracture group. These data were consistent with increased activity of myeloma cells that might cause bone destruction and fracture. Multiple myeloma has a peak incidence during the 7th decade, younger patients (< or = 40 yrs.o.) were rare. One 39-year-old man was successfully treated with surgery, chemotherapy and radiation therapy. Operative intervention seems to be quite important to improve the quality of life if longer survival is expected.
authors.affiliation: Department of Orthopedic Surgery Bridgeport Hospital, CT 06610, USA.
authors.forename: T
authors.initials: T
authors.lastname: Takei
authors.forename: M
authors.initials: M
authors.lastname: Coles
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001853:Bone Marrow / Q000473:pathology; D003131:Combined Modality Therapy; D005260:Female; D005598:Fractures, Spontaneous / Q000209:etiology / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications / Q000473:pathology / Q000601:surgery* / Q000628:therapy; D011379:Prognosis