title: Hypertensive cardiomegaly caused by an aldosterone-secreting adenoma in a newborn.
abstract: A case of primary hyperaldosteronism and cardiomegaly due to a unilateral adrenal adenoma in a newborn is presented. Some peculiarities, most likely in relation to the onset of the disease during fetal life were evident: plasma cortisol was slightly increased before surgery, plasma renin activity was elevated 9 months after surgery and mineralcorticoid receptors remained suppressed 4 months after surgery. Unilateral adrenalectomy reversed both hypertension and cardiomegaly. We speculate that cardiomegaly was related to both hyperaldosteronism and hypertension and that individual factors are involved in the pathogenesis of cardiomegaly in hyperaldosteronism.
authors.affiliation: Dipartimento di Pediatra, University of Padova, Italy.
authors.forename: G B
authors.initials: GB
authors.lastname: Pozzan
authors.forename: D
authors.initials: D
authors.lastname: Armanini
authors.forename: G
authors.initials: G
authors.lastname: Cecchetto
authors.forename: G
authors.initials: G
authors.lastname: Opocher
authors.forename: F
authors.initials: F
authors.lastname: Rigon
authors.forename: A
authors.initials: A
authors.lastname: Fassina
authors.forename: F
authors.initials: F
authors.lastname: Zacchello
mesh_terms: D000236:Adenoma / Q000150:complications* / Q000378:metabolism*; D000315:Adrenalectomy; D000450:Aldosterone / Q000378:metabolism*; D006332:Cardiomegaly / Q000209:etiology*; D006801:Humans; D006929:Hyperaldosteronism / Q000150:complications / Q000209:etiology; D006973:Hypertension / Q000150:complications / Q000209:etiology*; D007223:Infant; D008297:Male; D010911:Pituitary Neoplasms / Q000150:complications* / Q000378:metabolism*; D013997:Time Factors
chemical_list: D000450:Aldosterone