Elevated CSF corticotropin-releasing factor concentrations in posttraumatic stress disorder.
OBJECTIVE
Corticotropin-releasing factor (CRF) and somatostatin both play important roles in mediating responses to acute and chronic stress. The purpose of this study was to measure CSF concentrations of CRF and somatostatin in patients with chronic combat-related post-traumatic stress disorder (PTSD) and comparison subjects.


METHODS
Lumbar punctures for collection of CSF were performed in Vietnam combat veterans with PTSD (N = 11) and comparison subjects (N = 17). CSF concentrations of CRF and somatostatin were compared between the two groups.


RESULTS
CSF concentrations of CRF were higher in the PTSD patients than in the comparison subjects (mean = 29.0 pg/ml, SD = 7.8, versus mean = 21.9 pg/ml, SD = 6.0). This group difference remained significant after covariance for age. CSF somatostatin concentrations in PTSD patients were higher than those of the comparison subjects (mean = 19.9 pg/ml, SD = 5.4, versus mean = 13.7 pg/ml, SD = 8.0). However, covarying for age reduced the level of significance.


CONCLUSIONS
Higher CSF CRF concentrations in patients with PTSD may reflect alterations in stress-related neurotransmitter systems. The higher CSF CRF concentrations may play a role in disturbances of arousal in patients with PTSD.
Bremner
J D
JD
Department of Psychiatry, Yale University School of Medicine, New Haven, Conn., USA.
Licinio
J
J
Darnell
A
A
Krystal
J H
JH
Owens
M J
MJ
Southwick
S M
SM
Nemeroff
C B
CB
Charney
D S
DS
D000328:Adult; D000367:Age Factors; D001143:Arousal / Q000502:physiology; D003130:Combat Disorders / Q000134:cerebrospinal fluid / Q000503:physiopathology; D015897:Comorbidity; D003346:Corticotropin-Releasing Hormone / Q000134:cerebrospinal fluid*; D003866:Depressive Disorder / Q000134:cerebrospinal fluid / Q000453:epidemiology / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D018377:Neurotransmitter Agents / Q000502:physiology; D013004:Somatostatin / Q000134:cerebrospinal fluid; D013313:Stress Disorders, Post-Traumatic / Q000134:cerebrospinal fluid* / Q000453:epidemiology / Q000503:physiopathology
D018377:Neurotransmitter Agents; D013004:Somatostatin; D003346:Corticotropin-Releasing Hormone