[Characterization of antimicrobial properties of cefpirome].
The results of a multicentre investigation of antibiotic susceptibility in 800 clinical isolates were analyzed. The levels of susceptibility to cefpirome and other antibiotics in gram-negative organisms with inducable production of chromosomal beta-lactamases (Enterobacter, Serratia, Citrobacter and others) were compared and the advantages of cefpirome over other cephalosporins were shown: 89 per cent of the susceptible strains against 58 to 78 per cent. With respect to other microorganisms the advantages of cefpirome were less pronounced.
Sidorenko
S V
SV
Rezvan
S P
SP
Makarov
A N
AN
Makarova
R A
RA
D002463:Cell Membrane Permeability / Q000187:drug effects; D002511:Cephalosporins / Q000627:therapeutic use*; D002876:Chromosomes, Bacterial; D004353:Drug Evaluation, Preclinical; D006090:Gram-Negative Bacteria / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D013210:Staphylococcus / Q000187:drug effects; D018440:beta-Lactam Resistance / Q000502:physiology; D001618:beta-Lactamases / Q000235:genetics; D000097572:Cefpirome
D002511:Cephalosporins; D001618:beta-Lactamases; D000097572:Cefpirome