title: Phenotype of mice lacking functional Deleted in colorectal cancer (Dcc) gene.
abstract: The DCC (Deleted in colorectal cancer) gene was first identified as a candidate for a tumour-suppressor gene on human chromosome 18q. More recently, in vitro studies in rodents have provided evidence that DCC might function as a receptor for the axonal chemoattractant netrin-1. Inactivation of the murine Dcc gene caused defects in axonal projections that are similar to those observed in netrin-1-deficient mice but did not affect growth, differentiation, morphogenesis or tumorigenesis in mouse intestine. These observations fail to support a tumour-suppressor function for Dcc, but are consistent with the hypothesis that DCC is a component of a receptor for netrin-1.
authors.affiliation: Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Cambridge 02142, USA.
authors.forename: A
authors.initials: A
authors.lastname: Fazeli
authors.forename: S L
authors.initials: SL
authors.lastname: Dickinson
authors.forename: M L
authors.initials: ML
authors.lastname: Hermiston
authors.forename: R V
authors.initials: RV
authors.lastname: Tighe
authors.forename: R G
authors.initials: RG
authors.lastname: Steen
authors.forename: C G
authors.initials: CG
authors.lastname: Small
authors.forename: E T
authors.initials: ET
authors.lastname: Stoeckli
authors.forename: K
authors.initials: K
authors.lastname: Keino-Masu
authors.forename: M
authors.initials: M
authors.lastname: Masu
authors.forename: H
authors.initials: H
authors.lastname: Rayburn
authors.forename: J
authors.initials: J
authors.lastname: Simons
authors.forename: R T
authors.initials: RT
authors.lastname: Bronson
authors.forename: J I
authors.initials: JI
authors.lastname: Gordon
authors.forename: M
authors.initials: M
authors.lastname: Tessier-Lavigne
authors.forename: R A
authors.initials: RA
authors.lastname: Weinberg
mesh_terms: D000818:Animals; D001369:Axons / Q000473:pathology; D001921:Brain / Q000002:abnormalities / Q000196:embryology; D001932:Brain Neoplasms / Q000235:genetics; D015815:Cell Adhesion Molecules / Q000235:genetics / Q000502:physiology*; D002455:Cell Division; D002678:Chimera; D002874:Chromosome Mapping; D015179:Colorectal Neoplasms / Q000235:genetics; D000075389:DCC Receptor; D018390:Gene Targeting; D016163:Genes, DCC; D006801:Humans; D007413:Intestinal Mucosa / Q000473:pathology; D007414:Intestinal Neoplasms / Q000235:genetics*; D007417:Intestinal Polyps / Q000235:genetics; D051379:Mice; D008810:Mice, Inbred C57BL; D016296:Mutagenesis; D009414:Nerve Growth Factors / Q000502:physiology; D000075388:Netrin-1; D010641:Phenotype; D011956:Receptors, Cell Surface / Q000378:metabolism; D013116:Spinal Cord / Q000002:abnormalities / Q000196:embryology; D025521:Tumor Suppressor Proteins
chemical_list: D015815:Cell Adhesion Molecules; D000075389:DCC Receptor; C501909:DCC protein, human; C501910:Dcc protein, mouse; C000617351:NTN1 protein, human; D009414:Nerve Growth Factors; C000617353:Ntn1 protein, mouse; D011956:Receptors, Cell Surface; D025521:Tumor Suppressor Proteins; D000075388:Netrin-1