title: Fatal thromboembolism in acute promyelocytic leukaemia treated with a combination of all-trans retinoic acid and aprotonin.
abstract: We describe a case of acute promyelocytic leukaemia where the combined use of all-trans retinoic acid and an antifibrinolytic (aprotinin) may have contributed to worsening of coagulopathy.
authors.affiliation: Department of Haematology, Addenbrooke's NHS Trust, Cambridge, UK.
authors.forename: P
authors.initials: P
authors.lastname: Mahendra
authors.forename: D M
authors.initials: DM
authors.lastname: Keeling
authors.forename: I M
authors.initials: IM
authors.lastname: Hood
authors.forename: T P
authors.initials: TP
authors.lastname: Baglin
authors.forename: R E
authors.initials: RE
authors.lastname: Marcus
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D007611:Aprotinin / Q000009:adverse effects* / Q000627:therapeutic use; D017809:Fatal Outcome; D005260:Female; D006490:Hemostatics / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000188:drug therapy*; D013923:Thromboembolism / Q000139:chemically induced*; D014212:Tretinoin / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D006490:Hemostatics; D014212:Tretinoin; D007611:Aprotinin