A new translocation, t(3;6)(q12;24) associated with chronic myelomonocytic leukaemia and marrow fibrosis.
This report describes a 75-year-old man with chronic myelomonocytic leukaemia (CMML) and marked marrow fibrosis associated with t(3;6)(q12;24). Although structural abnormalities of 3q occur in haematological neoplasia, this particular chromosomal translocation has not been previously described in CMML. Karyotypic abnormalities involving 3q and marrow fibrosis may affect prognosis in CMML.
Krishnan
K
K
Division of Haematology-Oncology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, USA.
Sheldon
S
S
D000368:Aged; D002893:Chromosomes, Human, Pair 3; D002896:Chromosomes, Human, Pair 6; D006801:Humans; D007621:Karyotyping; D015477:Leukemia, Myelomonocytic, Chronic / Q000150:complications / Q000235:genetics*; D008297:Male; D055728:Primary Myelofibrosis / Q000209:etiology / Q000235:genetics*; D014178:Translocation, Genetic