Umbilical cord blood: an alternative to the transplantation of bone marrow stem cells.
Recent in vitro analyses of human UCB have demonstrated the potential of UCB as a source for haematopoietic stem and progenitor cell harvest. Clinical data have further indicated that UCB can be given in vivo to fully and partially HLA-matched siblings or non-familial recipients for marrow reconstitution in genetic disorders as well as malignancies. In comparison to adult peripheral blood, UCB displayed decreased immune responses to alloantigens and was enriched in the numbers of CD34+ progenitor cells with high proliferative and long-term marrow reconstituting potential. Cord blood banks now store large transplantable resources of UCB that are analysed with respect to immunological parameters. Cryopreserved UCB cells may fill the gap in finding a stem-cell transplant for patients who lack a matched related or unrelated donor when a bone marrow transplant is needed.
Weber-Nordt
R M
RM
Department of Hematology & Oncology, University of Freiburg Medical Center, Germany.
Schott
E
E
Finke
J
J
Henschler
R
R
Schulz
G
G
Mertelsmann
R
R
D001793:Blood Preservation; D016026:Bone Marrow Transplantation; D015925:Cryopreservation; D004992:Ethics, Medical; D005312:Fetal Blood / Q000166:cytology*; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007231:Infant, Newborn; D014481:United States; D014486:United States Food and Drug Administration