title: Deliberate self-poisoning with dapsone. A case report and summary of relevant pharmacology and treatment.
abstract: We report the case of a 14-year-old girl who deliberately ingested 8-9 g of dapsone and presented with severe methaemoglobinaemia and altered mental status. Prompt treatment with repeated doses of methylene blue and organ support brought about control of the methaemoglobinaemia and averted organ failure.
authors.affiliation: Department of Anaesthetics, Craigavon Area Hospital Group NHS Trust, Northern Ireland.
authors.forename: A J
authors.initials: AJ
authors.lastname: Ferguson
authors.forename: G G
authors.initials: GG
authors.lastname: Lavery
mesh_terms: D000293:Adolescent; D000931:Antidotes / Q000627:therapeutic use; D001663:Bilirubin / Q000097:blood; D003422:Critical Care / Q000379:methods; D003622:Dapsone / Q000506:poisoning*; D005260:Female; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000097:blood; D007917:Leprostatic Agents / Q000506:poisoning*; D008708:Methemoglobinemia / Q000139:chemically induced* / Q000628:therapy; D008751:Methylene Blue / Q000627:therapeutic use; D012121:Respiration, Artificial
chemical_list: D000931:Antidotes; D007917:Leprostatic Agents; D003622:Dapsone; D007770:L-Lactate Dehydrogenase; D001663:Bilirubin; D008751:Methylene Blue