title: Cyclosporine A affects serotonergic mechanisms in uremic rats.
abstract: The aim of this study was to investigate the mechanism of cyclosporine-induced hypertension in respect to its action on blood serotonergic system. The experiment was carried out on healthy rats and animals with experimental chronic renal failure. Cyclosporine A (CsA) injected into the healthy and uremic rats caused an increase in systolic blood pressure. This effect was completely abolished by ketanserin, an antagonist of 5-HT2 receptors. Concomitantly a rise in blood and platelet serotonin concentration was observed. It is concluded that serotonin may play a role in the development of hypertension caused by CsA. Moreover, ketanserin may serve as a drug for pharmacological protection of CsA-induced rise of blood pressure in uremia.
authors.affiliation: Department of Pharmacodynamics, Medical Academy, Białystok, Poland.
authors.forename: D
authors.initials: D
authors.lastname: Krygicz
authors.forename: A
authors.initials: A
authors.lastname: Azzadin
authors.forename: R
authors.initials: R
authors.lastname: Pawlak
authors.forename: J S
authors.initials: JS
authors.lastname: Małyszko
authors.forename: D
authors.initials: D
authors.lastname: Pawlak
authors.forename: M
authors.initials: M
authors.lastname: Myśliwiec
authors.forename: W
authors.initials: W
authors.lastname: Buczko
mesh_terms: D000244:Adenosine Diphosphate / Q000494:pharmacology; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D016572:Cyclosporine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D007650:Ketanserin / Q000494:pharmacology; D007676:Kidney Failure, Chronic / Q000503:physiopathology; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D012701:Serotonin / Q000097:blood / Q000502:physiology*; D014511:Uremia / Q000503:physiopathology*
chemical_list: D012701:Serotonin; D000244:Adenosine Diphosphate; D016572:Cyclosporine; D007650:Ketanserin