Attempts to use liposomes and RBC ghosts as vectors in drug and antisense therapy of virus infection.
Selective targeting of drugs or oligonucleotide for the treatment of viral diseases or cancer is the objective of new strategies that pursue therapy optimization and reduction of toxicity. In this work we report two protocols based on encapsulation of anti-human immunodeficiency virus drugs within targeted liposomes or erythrocytes. Both have been shown to be effective for the specific delivery of drugs or oligonucleotide in the treatment of viral infection.
Grimaldi
S
S
Istituto di Medicina Sperimentale C.N.R., Roma, Italy.
Lisi
A
A
Pozzi
D
D
Santoro
N
N
D000225:Adenine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D000998:Antiviral Agents / Q000008:administration & dosage* / Q000494:pharmacology; D002478:Cells, Cultured; D004337:Drug Carriers; D004910:Erythrocyte Membrane; D015497:HIV-1 / Q000187:drug effects; D006801:Humans; D008081:Liposomes; D016376:Oligonucleotides, Antisense / Q000008:administration & dosage* / Q000494:pharmacology; D063065:Organophosphonates; D014777:Virus Diseases / Q000188:drug therapy*
D000998:Antiviral Agents; D004337:Drug Carriers; D008081:Liposomes; D016376:Oligonucleotides, Antisense; D063065:Organophosphonates; C053001:adefovir; D000225:Adenine