Predisposition testing for breast and ovarian cancer susceptibility.
OBJECTIVE
To provide an overview of breast cancer predisposition syndromes and the breast and Ovarian cancer susceptibility genes identified to date. To describe the clinical implications of genetic testing for breast and ovarian cancer susceptibility.


METHODS
Published research and educational manuscripts, books, conference proceedings, and personal experiences.


CONCLUSIONS
Nurses must become knowledgeable of predisposition genetic testing for inherited breast cancer risk including: understanding of the gene being analyzed and associated cancer risks, indications for testing, the limitations of the test, the management options for mutation carriers, risks and benefits of testing, and the long-term psychosocial sequelae.


CONCLUSIONS
Predisposition testing for alterations in breast cancer susceptibility genes is rapidly moving into the general oncology and primary care community where nurses will play a major role in the provision of genetic services. The role of nursing in cancer genetics includes practice and education, nursing research, and policy initiatives.
Calzone
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Cancer Risk Evaluation Program, University of Pennsylvania Cancer Center, Philadelphia 19104, USA.
D001943:Breast Neoplasms / Q000235:genetics* / Q000517:prevention & control*; D015984:Causality; D005260:Female; D019398:Genes, BRCA1 / Q000235:genetics; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing / Q000379:methods*; D006801:Humans; D009154:Mutation / Q000235:genetics; D009859:Oncology Nursing; D010051:Ovarian Neoplasms / Q000235:genetics* / Q000517:prevention & control*; D010375:Pedigree; D012680:Sensitivity and Specificity