Frequent loss of heterozygosity in the region of the D7S523 locus in advanced ovarian cancer.
Loss of heterozygosity (LOH) of the long arm of chromosome 7 occurs frequently in many types of primary cancers. We analyzed 22 primary ovarian cancers for LOH of chromosome arm 7q using a set of 16 microsatellite markers in order to determine the location of a putative tumor suppressor gene (TSG). Eleven samples (50%) showed LOH at least at one locus on chromosome arm 7q. We identified the smallest commonly deleted region to be at 7q31.1, which includes D7S523. LOH of chromosome arm 7q was more frequent in advanced stages (III-IV) (7/9, 78%) than in early stages (I-II) (4/13.31%) of ovarian cancer (P < 0.05). These data suggest that alteration of a TSG at 7q31.1 gene plays an important role in advanced ovarian cancer.
Koike
M
M
Division of Hematology/Oncology, Cedars-Sinai Research Institute, UCLA School of Medicine 90048, USA.
Takeuchi
S
S
Yokota
J
J
Park
S
S
Hatta
Y
Y
Miller
C W
CW
Tsuruoka
N
N
Koeffler
H P
HP
D002872:Chromosome Deletion; D002874:Chromosome Mapping; D002897:Chromosomes, Human, Pair 7; D005260:Female; D016147:Genes, Tumor Suppressor; D006579:Heterozygote; D006801:Humans; D018895:Microsatellite Repeats; D010051:Ovarian Neoplasms / Q000235:genetics*