Selective cytotoxicity of ginkgetin from Selaginella moellendorffii.
Bioassay-directed fractionation of an ethanolic extract of Selaginella moellendorffii has led to the isolation of a known biflavone, ginkgetin (1). A dose-dependent inhibition was observed with 1 on the growth of OVCAR-3 (human ovarian adenocarcinoma) cells with 50% inhibition occurring at 1.8 micrograms/mL. Nonbioactive fractions yielded four additional known biflavones, amentoflavone 7,4',7",4"'-tetramethyl ether, kayaflavone, podocarpusflavone A, and amentoflavone.
Sun
C M
CM
National Research Institute of Chinese Medicine, Taipei, Taiwan.
Syu
W J
WJ
Huang
Y T
YT
Chen
C C
CC
Ou
J C
JC
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D044946:Biflavonoids; D002522:Chlorocebus aethiops; D004354:Drug Screening Assays, Antitumor; D005419:Flavonoids / Q000494:pharmacology*; D006801:Humans; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D014407:Tumor Cells, Cultured; D014709:Vero Cells
D000972:Antineoplastic Agents, Phytogenic; D044946:Biflavonoids; D005419:Flavonoids; D010936:Plant Extracts; C077458:ginkgetin