Brodifacoum intoxication with marijuana smoking.
We report the case of a 17-year-old boy with a significant history of drug and alcohol abuse, which included smoking marijuana mixed with brodifacoum. As a consequence, the patient developed a prolonged coagulopathy that persisted for more than 1 year. To our knowledge, this is the first case reported in the literature in which super-warfarin intoxication has been associated with marijuana smoking. This report should increase the awareness of pathologists and clinicians when examining a patient with a history of drug abuse who exhibits persistent vitamin K1-dependent coagulopathy.
La Rosa
F G
FG
Department of Pathology and the Webb-Waring Institute for Biomedical Research, Denver, Colo 80262, USA.
Clarke
S H
SH
Lefkowitz
J B
JB
D015110:4-Hydroxycoumarins / Q000506:poisoning*; D000293:Adolescent; D001777:Blood Coagulation / Q000187:drug effects*; D001779:Blood Coagulation Factors / Q000032:analysis; D005171:Factor X Deficiency / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy; D006801:Humans; D008297:Male; D008385:Marijuana Smoking; D011517:Prothrombin Time; D012378:Rodenticides / Q000506:poisoning*; D010837:Vitamin K 1 / Q000008:administration & dosage / Q000037:antagonists & inhibitors
D015110:4-Hydroxycoumarins; D001779:Blood Coagulation Factors; D012378:Rodenticides; D010837:Vitamin K 1; C013418:bromfenacoum