The genetics of melanoma.
OBJECTIVE
To review the current status and recent advances of genetic epidemiology research in familial melanoma, and the implications for primary and secondary prevention of melanoma.


METHODS
Research studies, review articles, and book chapters pertaining to melanoma susceptibility factors.


CONCLUSIONS
Molecular genetic studies examining candidate genes for melanoma are being pursued vigorously. Considering the complexities and heterogeneity in the genetics of familial melanoma, predictive testing is not currently recommended as an established method for identifying individuals with a genetic predisposition to melanoma.


CONCLUSIONS
An understanding of the genetics of melanoma will help oncology nurses in translating the appropriate clinical implications for primary and secondary prevention related to melanoma.
Fraser
M C
MC
Genetic Epidemiology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-7372, USA.
Goldstein
A M
AM
Tucker
M A
MA
D006801:Humans; D008545:Melanoma / Q000453:epidemiology* / Q000235:genetics* / Q000517:prevention & control; D008967:Molecular Biology; D009859:Oncology Nursing; D010375:Pedigree; D011322:Primary Prevention; D012307:Risk Factors; D013472:Sunlight / Q000009:adverse effects