title: Phosphorylation-dependent control of structures of intermediate filaments: a novel approach using site- and phosphorylation state-specific antibodies.
abstract: Site-specific phosphorylation of intermediate filament (IF) proteins on serine and threonine residues leads to dynamic alterations in filament structure. Site- and phosphorylation state-specific antibodies for IF proteins can visualize spatial and temporal distribution of site-specific IF protein phosphorylations in the cell. These antibodies are also useful to identity IF kinases involved in cellular events, including cell signaling and cell cycle.
authors.affiliation: Laboratory of Biochemistry, Aichi Cancer Center Research Institute, Chikusa-ku, Nagoya.
authors.forename: M
authors.initials: M
authors.lastname: Inagaki
authors.forename: N
authors.initials: N
authors.lastname: Inagaki
authors.forename: T
authors.initials: T
authors.lastname: Takahashi
authors.forename: Y
authors.initials: Y
authors.lastname: Takai
mesh_terms: D000906:Antibodies / Q000737:chemistry*; D007381:Intermediate Filament Proteins / Q000737:chemistry* / Q000276:immunology / Q000378:metabolism; D010766:Phosphorylation; D011487:Protein Conformation; D011494:Protein Kinases / Q000378:metabolism
chemical_list: D000906:Antibodies; D007381:Intermediate Filament Proteins; D011494:Protein Kinases