Reactive nonstress test despite severe congenital brain damage. What does the test measure?
BACKGROUND
Antenatal testing with the nonstress test is common in the evaluation of high-risk pregnancies. A reactive test gives the clinician reassurance of fetal well-being.


METHODS
A 19-year-old woman, gravida 1, para 0, delivered an infant with holoprosencephaly and multiple facial and limb abnormalities at 38 weeks' gestation. The fetal heart tracing was reassuring despite the infant's compromised neurologic status.


CONCLUSIONS
The nonstress test is dependent only upon the fetal brainstem, and it predicts oxygenation at that site rather than normality of the entire central nervous system. This limitation of the nonstress test must be remembered when performing antenatal testing.
Cardosi
R J
RJ
Department of Obstetrics and Gynecology, University of South Florida College of Medicine, Tampa 33606, USA.
Heffron
J A
JA
Spellacy
W N
WN
D000328:Adult; D001921:Brain / Q000002:abnormalities*; D001933:Brain Stem / Q000502:physiology; D015148:Cardiotocography; D005260:Female; D016142:Holoprosencephaly / Q000175:diagnosis*; D006801:Humans; D011247:Pregnancy; D018566:Pregnancy, High-Risk; D011296:Prenatal Diagnosis