title: Assignment of Alzheimer's presenilin-2 (PS-2) gene to 1q42.1 by fluorescence in situ hybridization.
abstract: Presenilin-2 (PS-2) was suggested to be localized on 1q31-42 based on linkage analysis and cDNA cloning. The final identification of PS-2 as the causal gene for early-onset familial Alzheimer's disease in Voga-German pedigrees was concluded based on the point mutation found in the candidate cDNA isolated from this familial AD. We present evidence of its physical genome mapping of PS-2 on chromosome 1q42.1 by fluorescence in situ hybridization method.
authors.affiliation: Department of Hygiene and Public Health, Teikyo University School of Medicine, Kaga, Itabashiku, Tokyo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Takano
authors.forename: N
authors.initials: N
authors.lastname: Sahara
authors.forename: Y
authors.initials: Y
authors.lastname: Yamanouchi
authors.forename: H
authors.initials: H
authors.lastname: Mori
mesh_terms: D000544:Alzheimer Disease / Q000235:genetics*; D002874:Chromosome Mapping; D002900:Chromosomes, Human, 1-3 / Q000502:physiology*; D016650:Fluorescein-5-isothiocyanate; D008040:Genetic Linkage; D006801:Humans; D017403:In Situ Hybridization; D008565:Membrane Proteins / Q000235:genetics*; D008856:Microscopy, Fluorescence; D017354:Point Mutation; D053766:Presenilin-2
chemical_list: D008565:Membrane Proteins; C508861:PSEN2 protein, human; D053766:Presenilin-2; D016650:Fluorescein-5-isothiocyanate