title: Changes in protein metabolism in hemolymph and fat body of the silkworm, Bombyx mori (Lepidoptera: Bombycidae) in response to organophosphorus insecticides toxicity.
abstract: Changes in protein metabolism were studied in hemolymph and fat body of 5th instar silkworm Bombyx mori exposed to lethal and sublethal doses of fenitrothion and ethion. The total protein content indicated a depletion followed by a concomitant increase in accumulation of free amino acids. Concurrently, the activity of protease in both of the tissues was also increased. A sharp enhancement in the activities of alanine aminotransferase and aspartate aminotransferase paralleled the elevation of glutamate dehydrogenase activity in the tissues studied. All these changes clearly documented the induction of severe proteolysis and transamination of amino acids.
authors.affiliation: Department of Zoology, Sri Krishnadevaraya University, Anantapur, India.
authors.forename: B S
authors.initials: BS
authors.lastname: Nath
authors.forename: A
authors.initials: A
authors.lastname: Suresh
authors.forename: B M
authors.initials: BM
authors.lastname: Varma
authors.forename: R P
authors.initials: RP
authors.lastname: Kumar
mesh_terms: D000410:Alanine Transaminase / Q000187:drug effects / Q000378:metabolism; D000596:Amino Acids / Q000032:analysis; D000818:Animals; D001219:Aspartate Aminotransferases / Q000187:drug effects / Q000378:metabolism; D012831:Bombyx / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism*; D010450:Endopeptidases / Q000187:drug effects / Q000378:metabolism; D005216:Fat Body / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism*; D005278:Fenitrothion / Q000633:toxicity*; D005969:Glutamate Dehydrogenase / Q000187:drug effects / Q000378:metabolism; D006458:Hemolymph / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism*; D019476:Insect Proteins / Q000187:drug effects / Q000378:metabolism*; D007306:Insecticides / Q000633:toxicity*; D007928:Lethal Dose 50; D009946:Organothiophosphorus Compounds / Q000633:toxicity*
chemical_list: D000596:Amino Acids; D019476:Insect Proteins; D007306:Insecticides; D009946:Organothiophosphorus Compounds; C100038:ethion; D005969:Glutamate Dehydrogenase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D010450:Endopeptidases; D005278:Fenitrothion