Structural correlates of cognition in dementia: quantification and assessment of synapse change.
Dementia results from a combination of structural and neurochemical pathologies. The most reliable index of cognition in both postmortem and biopsied AD brain is synapse loss.
DeKosky
S T
ST
Department of Psychiatry, Western Psychiatric Institute & Clinic, Pittsburgh, PA 15261, USA. dekosky@vms.cis.pitt.edu
Scheff
S W
SW
Styren
S D
SD
D000544:Alzheimer Disease / Q000378:metabolism / Q000473:pathology* / Q000523:psychology*; D003071:Cognition; D018891:Dentate Gyrus / Q000473:pathology; D004797:Enzyme-Linked Immunosorbent Assay; D005625:Frontal Lobe / Q000473:pathology; D006801:Humans; D013569:Synapses / Q000648:ultrastructure*; D016708:Synaptophysin / Q000378:metabolism; D013702:Temporal Lobe / Q000473:pathology
D016708:Synaptophysin