title: Induction characteristics of 2% propofol in children.
abstract: We have conducted a prospective, randomized study to evaluate the characteristics of induction of anaesthesia in children with 2% propofol. Children were allocated to receive propofol 3 mg kg-1 (group A), 4 mg kg-1 (group B) or 5 mg kg-1 (group C) of the 2% formulation. We observed a high incidence of spontaneous movements (90%) in group A and an incidence of coughing of 70% in group C. Induction in group B was characterized by a short induction time, low incidence of spontaneous movements (20%), pain on injection (10%) and excellent conditions for manual ventilation.
authors.affiliation: Department of Anaesthesiology, University Hospital of Geneva, Switzerland.
authors.forename: A
authors.initials: A
authors.lastname: Borgeat
authors.forename: T
authors.initials: T
authors.lastname: Fuchs
authors.forename: E
authors.initials: E
authors.lastname: Tassonyi
mesh_terms: D018686:Anesthetics, Intravenous / Q000008:administration & dosage* / Q000494:pharmacology; D002626:Chemistry, Pharmaceutical; D002648:Child; D002675:Child, Preschool; D003371:Cough / Q000139:chemically induced; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D009068:Movement / Q000187:drug effects; D010038:Otorhinolaryngologic Diseases / Q000601:surgery; D015742:Propofol / Q000008:administration & dosage* / Q000494:pharmacology; D011446:Prospective Studies
chemical_list: D018686:Anesthetics, Intravenous; D015742:Propofol