title: Personality disorder scores improve with effective pharmacotherapy of depression.
abstract: BACKGROUND
  We hypothesized that the probability of personality disorder ('PROB') predicted by the Temperament and Character Inventory ('TCI') would decline after successful pharmacotherapy of depression.
  
  
  METHODS
  We administered a computerized version of the TCI to 15 patients with DSM-III-R major depression, before and after treatment with serotonergic antidepressants.
  
  
  RESULTS
  PROB declined from 58.9% +/- 18.0% to 42.4% +/- 22.8% (P < 0.003), due to a significant increase in the Self-Directedness scale. This change in PROB correlated with improvement in self-rated severity of depression (P < 0.02).
  
  
  CONCLUSIONS
  TCI prediction of personality disorder is susceptible to state effects of depression.
authors.affiliation: Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110-1093, USA. Kevin_Black@npg.wustl.edu
authors.forename: K J
authors.initials: KJ
authors.lastname: Black
authors.forename: Y I
authors.initials: YI
authors.lastname: Sheline
mesh_terms: D000328:Adult; D018687:Antidepressive Agents, Second-Generation / Q000009:adverse effects / Q000627:therapeutic use*; D003866:Depressive Disorder / Q000175:diagnosis / Q000188:drug therapy* / Q000523:psychology; D004873:Ergolines / Q000009:adverse effects / Q000627:therapeutic use; D005260:Female; D005473:Fluoxetine / Q000009:adverse effects / Q000627:therapeutic use; D016666:Fluvoxamine / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D017374:Paroxetine / Q000009:adverse effects / Q000627:therapeutic use; D010554:Personality Disorders / Q000175:diagnosis* / Q000188:drug therapy; D010555:Personality Inventory; D012702:Serotonin Antagonists / Q000009:adverse effects / Q000627:therapeutic use
chemical_list: D018687:Antidepressive Agents, Second-Generation; D004873:Ergolines; D012702:Serotonin Antagonists; D005473:Fluoxetine; D017374:Paroxetine; C066736:amesergide; D016666:Fluvoxamine