Treatment of enteric fever with pefloxacin for 7 days versus 5 days: a randomized clinical trial.
In this prospective study of enteric fever, 22 patients received 400 mg of pefloxacin twice daily for 5 days (group A) and 24 received 400 mg of pefloxacin twice daily for 7 days (group B). Causative microorganisms were Salmonella typhi (8 in group A, 11 in group B) and Salmonella paratyphi B (14 in group A, 13 in group B). The clinical cure and bacterial eradication rates were 96% (21 of 22) in group A and 100% in group B. In conclusion, 5-day oral administration of pefloxacin was as effective as 7-day treatment of enteric fever caused by Salmonella spp.
Unal
S
S
Department of Internal Medicine, School of Medicine, Hacettepe University, Ankara, Turkey. su04-k@servis2.net.tr
Hayran
M
M
Tuncer
S
S
Gür
D
D
Uzun
O
O
Akova
M
M
Akalin
H E
HE
D042462:4-Quinolones; D000293:Adolescent; D000328:Adult; D000368:Aged; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D005260:Female; D024841:Fluoroquinolones; D006801:Humans; D008297:Male; D008875:Middle Aged; D010284:Paratyphoid Fever / Q000188:drug therapy*; D011446:Prospective Studies; D015363:Quinolones / Q000008:administration & dosage / Q000627:therapeutic use*; D012484:Salmonella paratyphi B; D016896:Treatment Outcome; D014435:Typhoid Fever / Q000188:drug therapy*; D015366:Pefloxacin
D042462:4-Quinolones; D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D015363:Quinolones; D015366:Pefloxacin