title: Dynamic vectorcardiography for early diagnosis of acute myocardial infarction compared with 12-lead electrocardiogram. BIOMACS Study Group.
abstract: BACKGROUND
  The aim of the study was to assess the diagnostic accuracy of multilead continuous vectorcardiography (VCG) for early diagnosis of acute myocardial infarction (AMI) in patients admitted to hospital because of suspicion of AMI. VCG was compared with resting 12-lead electrocardiogram (ECG) on admission.
  
  
  METHODS
  In a multicentre study, 107 patients with chest pain (< or = 12 h) were included. The diagnosis of AMI was on the basis of World Health Organization criteria. Continuous VCG was recorded for 12-24 h and the data were evaluated blindly at 2 and 6 h of recording and after the completion of recording (12-24 h).
  
  
  RESULTS
  AMI was diagnosed in 74 patients. The VCG recording had a diagnostic accuracy of 71% after 2 h and 86% after both the 6 h and the completed VCG recording. Compared with ECG on admission, the VCG recording after 6 h showed a significantly greater sensitivity: 86% compared with 62% (P < 0.01). In patients with non-diagnostic ECG on arrival (n = 55), VCG after 6 h had a diagnostic accuracy of 85%, a sensitivity of 82% and a specificity of 89%.
  
  
  CONCLUSIONS
  VCG might be useful for early diagnosis of AMI, especially in patients with non-diagnostic ECG.
authors.affiliation: Department of Medicine, Gävle Hospital, Sweden.
authors.forename: G
authors.initials: G
authors.lastname: Gustafsson
authors.forename: M
authors.initials: M
authors.lastname: Dellborg
authors.forename: B
authors.initials: B
authors.lastname: Lindahl
authors.forename: L
authors.initials: L
authors.lastname: Wallentin
mesh_terms: D004562:Electrocardiography; D006801:Humans; D009203:Myocardial Infarction / Q000175:diagnosis* / Q000188:drug therapy; D012680:Sensitivity and Specificity; D015912:Thrombolytic Therapy; D013997:Time Factors; D014672:Vectorcardiography