Persistent short term memory deficits in Hebb-Williams maze performance are shown by rats with unilateral entorhinal cortex lesions.
The spatial abilities of adult, male Sprague-Dawley rats in the Hebb-Williams maze were examined at 6 months after unilateral electrolytic entorhinal cortex lesions. Compared with sham-operated rats, their performance was impaired in both initial entry and repeat entry errors over 12 consecutive problems, using immediate starting replacement for the 6 trials per problem. The configurations of the 12 maze problems are independent, and deficits were seen over the entire course of the testing. This study indicates that Hebb-Williams maze performance deficits after unilateral entorhinal cortex lesion are persistent and can be seen up to 6 months after injury.
Glasier
M M
MM
Brain Research Laboratory, Institute of Animal Behavior, Rutgers University, USA.
Janis
L S
LS
Stein
D G
DG
D000818:Animals; D001931:Brain Mapping; D004292:Dominance, Cerebral / Q000502:physiology*; D018728:Entorhinal Cortex / Q000502:physiology*; D008297:Male; D018782:Maze Learning / Q000502:physiology*; D008570:Memory, Short-Term / Q000502:physiology*; D011340:Problem Solving / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012153:Retention, Psychology / Q000502:physiology