title: 5-HT3 receptors and central effects of ethanol.
abstract: This review discusses recent experimental findings in serotonin-3 (5-HT3) receptors and ethanol (EtOH) research. The role of these receptors in central effects of EtOH including the effects of 5-HT3 agonists and antagonists on EtOH intake, rewarding and aversive properties of EtOH and EtOH interoceptive cue is reviewed. It is now recognized that 5-HT3 receptors while involved in EtOH intake, EtOH tolerance and withdrawal and rewarding mechanisms do not play an important role in aversive effects of EtOH and EtOH discriminative stimulus. 5-HT3 receptors involved in EtOH consumption are supposedly located on dopaminergic neurons in the nucleus accumbens.
authors.affiliation: Department of Pharmacology and Physiology of the Nervous System, Institute of Psychiatry and Neurology, Warszawa, Poland.
authors.forename: W
authors.initials: W
authors.lastname: Kostowski
mesh_terms: D000437:Alcoholism / Q000503:physiopathology; D000818:Animals; D000431:Ethanol / Q000494:pharmacology*; D018377:Neurotransmitter Agents / Q000502:physiology; D011985:Receptors, Serotonin / Q000187:drug effects / Q000502:physiology*; D044406:Receptors, Serotonin, 5-HT3; D012702:Serotonin Antagonists / Q000494:pharmacology; D017366:Serotonin Receptor Agonists / Q000494:pharmacology
chemical_list: D018377:Neurotransmitter Agents; D011985:Receptors, Serotonin; D044406:Receptors, Serotonin, 5-HT3; D012702:Serotonin Antagonists; D017366:Serotonin Receptor Agonists; D000431:Ethanol