[Chirality and drugs].
Following a brief historical review of the notion of chirality, the importance of the relationship between pharmacological activity and the enantiomeric forms of drugs is indicated. Different approaches for the preparation of optically-pure molecules are discussed, and an original strategy, known as the "CN(R,S) method", is described. To conclude, an application of this method in the synthesis of a pharmacologically-active molecule is presented.
Husson
H P
HP
Laboratoire de Chimie Thérapeutique associé au CNRS, Faculté des Sciences Pharmaceutiques, Université René-Descartes, Paris.
D003959:Diamines / Q000737:chemistry / Q000494:pharmacology; D008722:Methods; D055095:Optics and Photonics; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D010600:Pharmacology; D013237:Stereoisomerism
D003959:Diamines; D004364:Pharmaceutical Preparations