title: Reproducibility and reliability of volumetric measurements of olfactory eloquent structures.
abstract: OBJECTIVE
  The authors assessed the reliability and reproducibility of volumetric measurements of olfactory bulbs and tracts (OBTs) and temporal lobes (TLs) with magnetic resonance (MR) imaging.
  
  
  METHODS
  Repetitive MR imaging of two phantoms and OBTs and TLs of patients was performed. Regions of interest were manually drawn around the relevant structures, and their volumes were measured at workstations. Intra- and interobserver variability for the two readers were measured. Intraclass and Pearson correlation coefficients and mean percentage differences were calculated.
  
  
  RESULTS
  The measured phantom volumes were within 1.9%-12% of the true volumes with a variability of < or = 5%. Intraclass and Pearson correlation coefficients were > or = 0.919 for measurements by a single reader and > or = 0.924 for measurements by different readers. The inter- and intraobserver variabilities were < or = 4.2% for TL and 11.3%-14.6% for OBTs.
  
  
  CONCLUSIONS
  Volumetric measurements of the olfactory apparatus can be reliably and accurately reproduced from MR images.
authors.affiliation: Department of Radiology, University of Pennsylvania Medical Center, Philadelphia 19104, USA.
authors.forename: D M
authors.initials: DM
authors.lastname: Yousem
authors.forename: R J
authors.initials: RJ
authors.lastname: Geckle
authors.forename: R L
authors.initials: RL
authors.lastname: Doty
authors.forename: W B
authors.initials: WB
authors.lastname: Bilker
mesh_terms: D006801:Humans; D008279:Magnetic Resonance Imaging; D015588:Observer Variation; D009830:Olfactory Bulb / Q000033:anatomy & histology; D009833:Olfactory Pathways / Q000033:anatomy & histology*; D019047:Phantoms, Imaging; D015203:Reproducibility of Results; D013702:Temporal Lobe / Q000033:anatomy & histology