[Cerebrospinal fluid in the diagnosis of cerebro-meningeal metastasis from malignant melanoma arising from giant congenital melanocytic nevus: case report].
We describe the case of a 28-year-old man with a giant congenital melanocytic nevus (GCMN) with malignant transformation to melanoma and metastasis on the central nervous system (CNS). We also make a summary of the pathological features from both lesions (GCMN and Melanoma), the occurrence of malignancy of GCMN, the organs more frequently involved with metastatic melanoma--with emphasis to involvement of CNS--just as the factors that cause malignant transformation of GCMN; the methods to diagnose metastases in CNS--emphasizing the importance of cerebrospinal fluid--and some therapeutical modalities for the metastatic melanoma in CNS.
Rolim
J A
JA
Escola Paulista de Medicina (EPM) da Universidade Federal de São Paulo(UNIFESP), Brasil.
Barsottini
O G
OG
Prado
G F
GF
Nakandakare
F
F
Reis
M L
ML
Reis-Filho
J B
JB
D000328:Adult; D001932:Brain Neoplasms / Q000134:cerebrospinal fluid* / Q000175:diagnosis / Q000556:secondary*; D006801:Humans; D008297:Male; D008545:Melanoma / Q000473:pathology*; D008577:Meningeal Neoplasms / Q000134:cerebrospinal fluid* / Q000175:diagnosis / Q000556:secondary*; D009378:Neoplasms, Multiple Primary / Q000473:pathology*; D009508:Nevus, Pigmented / Q000151:congenital* / Q000473:pathology*; D012878:Skin Neoplasms / Q000151:congenital* / Q000473:pathology*