Production of brominated tiacumicin derivatives.
Several novel tiacumicin derivatives containing bromine have been produced by the addition of inorganic bromine to the fermentation both of Dactylosporangium aurantiacum subsp, hamdenensis. Structures were elucidated employing mass spectrometry and NMR spectroscopy. Antibacterial activity of the bromotiacumicins is comparable to that of the parent compounds.
Hochlowski
J E
JE
Pharmaceutical Products Research, Abbott Park, Illinois 60064, USA.
Jackson
M
M
Rasmussen
R R
RR
Buko
A M
AM
Clement
J J
JJ
Whittern
D N
DN
McAlpine
J B
JB
D000192:Actinomycetales / Q000378:metabolism*; D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000737:chemistry / Q000494:pharmacology; D001966:Bromine; D005285:Fermentation; D018942:Macrolides
D000900:Anti-Bacterial Agents; D018942:Macrolides; D001966:Bromine