title: Biopsy Gleason score: how does it correlate with the final pathological diagnosis in prostate cancer?
abstract: OBJECTIVE
  To evaluate the role of the Gleason score of needle biopsies of the prostate in predicting the final pathological staging of patients with carcinoma of the prostate treated by radical prostatectomy.
  
  
  METHODS
  The records of 466 patients with carcinoma of the prostate treated by radical prostatectomy were reviewed, comparing the Gleason scores of the core-needle biopsies with the Gleason score and final pathological staging of the surgical specimens.
  
  
  RESULTS
  The biopsy grade was the same as that of the prostatectomy specimen in 54% of the patients. The most common discordance was the upgrading of well-differentiated tumours in 75% of the patients. When the biopsy grade was compared with the surgical pathological stage, 49% of low- and 82% of high-grade lesions in the biopsy had capsular penetration by tumour or locally advanced disease (Stage C and D1).
  
  
  CONCLUSIONS
  Well-differentiated tumours on the biopsy core are not predictive of organ-confined disease, but a poorly differentiated lesion is a good indicator of extracapsular extension of the cancer.
authors.affiliation: Department of Urology, University of Minnesota, Minneapolis, USA.
authors.forename: E T
authors.initials: ET
authors.lastname: Fernandes
authors.forename: C P
authors.initials: CP
authors.lastname: Sundaram
authors.forename: R
authors.initials: R
authors.lastname: Long
authors.forename: M
authors.initials: M
authors.lastname: Soltani
authors.forename: C J
authors.initials: CJ
authors.lastname: Ercole
mesh_terms: D001707:Biopsy, Needle; D005544:Forecasting; D006801:Humans; D008197:Lymph Node Excision; D008207:Lymphatic Metastasis; D008297:Male; D009367:Neoplasm Staging / Q000379:methods*; D011467:Prostate / Q000473:pathology*; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000473:pathology* / Q000601:surgery; D012189:Retrospective Studies