title: 13beta,14beta-dihydroxy-13alpha-isopropylabietic acid, an elicitor of contact allergy.
abstract: Abietic acid isolated from colophony (W.W. grade) was selectively oxidized in the presence of KMnO4, into 13beta,14beta-dihydroxy-14alpha-isopropylabietic acid. The structure of the compound was elucidated using UV, IR, and NMR spectroscopy. Epicutaneous application of the dihydroxy acid to colophony-sensitized guinea pigs suggested the compound as an elicitor of contact allergy that had not been tested before in contact-sensitization reactions.
authors.affiliation: Natural Drugs Division, PCSIR Laboratories, Peshawar, Pakistan.
authors.forename: L
authors.initials: L
authors.lastname: Khan
authors.forename: M A
authors.initials: MA
authors.lastname: Saeed
mesh_terms: D045784:Abietanes; D000818:Animals; D003877:Dermatitis, Contact / Q000209:etiology*; D004224:Diterpenes / Q000378:metabolism / Q000633:toxicity*; D006168:Guinea Pigs; D010084:Oxidation-Reduction; D010616:Phenanthrenes / Q000378:metabolism / Q000633:toxicity*
chemical_list: D045784:Abietanes; D004224:Diterpenes; D010616:Phenanthrenes; C023710:abietic acid