title: Laparoscopic anterior extended seromyotomy with posterior truncal vagotomy: an experimental study.
abstract: We describe a new laparoscopic modification of parietal cell vagotomy. The laparoscopic anterior extended seromyotomy with posterior truncal vagotomy was performed in five pigs weighing 21 to 25 kg each. Congo-red and pH tests were undertaken 2 weeks later by open gastrotomy. The photographs of the stained gastric mucosa made at the 5-min interval after Congo-red administration were analyzed with a computer-driven area calculation program. Preoperative and postoperative weights were taken for all animals. The experimental parietal cell vagotomy group was compared with the sham group and showed a minimal amount of nondenervated parietal cell mass (0.9 +/- 0.4% versus 28.2 +/- 3.9%, p < 0.05). The pH values showed an inhibition of gastric acid secretion (7.8 +/- 0.7 versus 2.2 +/- 0.4, p < 0.05). During postoperative follow-up, no significant difference in the weight increase of the experimental and the sham control group was noticed (1.6 +/- 0.6 kg versus 2.0 +/- 0.1 kg, p < 0.27). The laparoscopic anterior extended seromyotomy with posterior truncal vagotomy efficiently suppresses gastric acid secretion, preserving the motility of the antrum and pylorus and diminishing the risk of residual areas of innervation. This procedure avoids dissection of the esophagus and can provide an easier but equally effective operative treatment of ulcer disease compared with other types of parietal cell vagotomy.
authors.affiliation: Department of Surgery, University Hospital Zurich, Switzerland.
authors.forename: P
authors.initials: P
authors.lastname: Zanchi
authors.forename: R
authors.initials: R
authors.lastname: Schlumph
authors.forename: N
authors.initials: N
authors.lastname: Aras
authors.forename: O
authors.initials: O
authors.lastname: Schöb
authors.forename: R
authors.initials: R
authors.lastname: Schmid
authors.forename: A
authors.initials: A
authors.lastname: Petricevic
authors.forename: F
authors.initials: F
authors.lastname: Largiadèr
mesh_terms: D000818:Animals; D010535:Laparoscopy; D013552:Swine; D014629:Vagotomy, Proximal Gastric / Q000379:methods*; D015167:Vagotomy, Truncal / Q000379:methods*