Orbital avitene granuloma formation after enucleation for intraocular retinoblastoma.
OBJECTIVE
To report a case of orbital foreign body granuloma formation, mimicking tumor recurrence, secondary to the use of Avitene after enucleation for intraocular retinoblastoma.


METHODS
Eight months after undergoing enucleation for retinoblastoma, a 21-month-old boy underwent a biopsy of an orbital mass.


RESULTS
Histopathologic examination of the orbital biopsy specimen disclosed a proliferative granulomatous foreign body reaction surrounding multiple foci of a coarse fibrillar intercellular substance consistent with Avitene. No retinoblastoma cells were present.


CONCLUSIONS
A foreign body reaction should be included in the differential diagnosis of orbital mass lesions after surgery in which Avitene is used.
Abramson
D H
DH
New York Hospital/Cornell Medical Center, NY, USA.
Andracchi
S
S
D003094:Collagen / Q000009:adverse effects*; D003937:Diagnosis, Differential; D015353:Eye Enucleation; D005134:Eye Neoplasms / Q000601:surgery*; D015745:Granuloma, Foreign-Body / Q000175:diagnosis / Q000209:etiology*; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging; D008297:Male; D009916:Orbital Diseases / Q000175:diagnosis / Q000209:etiology*; D012175:Retinoblastoma / Q000601:surgery*; D014057:Tomography, X-Ray Computed
D003094:Collagen