Preventive mitochondrial replacement.
Techniques used recently to clone a sheep generate chimeras with the genome of the donor cell and mainly the mitochondria of the acceptor egg. The use of the same techniques should allow a mother carrying a mitochondrial defect to bear a normal child with normal mitochondria.
Orgel
L E
LE
The Salk Institute for Biological Studies, PO Box 85800, San Diego, CA 92186 5800, USA. orgel@sc2.salk.edu
D000818:Animals; D003001:Cloning, Molecular; D004992:Ethics, Medical; D005818:Genetic Engineering; D006801:Humans; D008928:Mitochondria / Q000502:physiology*