Taxuspinananes A and B, new taxoids from Taxus cuspidata var. nana.
New taxoids, taxuspinanane A (1), showing potent cytotoxic activity, and taxuspinanane B (2), have been isolated from the stems of Taxus cuspidata Sieb. et. Zucc. var. nana Rehder. Their structures were elucidated by extensive 2D NMR and MS spectroscopic analysis.
Morita
H
H
Department of Pharmacognosy, Tokyo University of Pharmacy and Life Science, Japan.
Gonda
A
A
Wei
L
L
Yamamura
Y
Y
Takeya
K
K
Itokawa
H
H
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007941:Leukemia P388 / Q000188:drug therapy; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D017239:Paclitaxel / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D043823:Taxoids; D014315:Triterpenes / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D000972:Antineoplastic Agents, Phytogenic; D043823:Taxoids; D014315:Triterpenes; C106019:taxuspinanane A; C106020:taxuspinanane B; D017239:Paclitaxel