title: [Involvement of cardiac valves in antiphospholipid syndrome].
abstract: Antiphospholipid syndrome (APLS) is a clinicolaboratory symptom complex characterized by development of venous and/or arterial thromboses, thrombocytopenia, obstetric pathology arising in the presence of hyperproduction of antiphospholipid antibodies (APAB). APLS may occur not only in patients with systemic lupus erythematosus (SLE) or other autoimmune diseases as secondary APLS, but in those without the above diseases as the primary APLS. The authors have examined 34 patients with APLS versus 10 patients with a verified SLE free of APLS manifestations. Affection of the valves was found in 30 patients with APLS (88%). More frequent were additional structures on mitral and aortic valve cusps, thickening of mitral valve cusps in APLS patients. Evident valvular disease was seen only in APLS patients with high positive levels of APAB. Valvular lesions were similar in patients with primary and secondary APLS. The study has revealed a relationship between the presence of antibodies to phospholipids and valvular abnormalities in APLS patients.
authors.affiliation: Scientific Cardiological Center KNTs RAMN, Moscow.
authors.forename: L M
authors.initials: LM
authors.lastname: Sergakova
authors.forename: O A
authors.initials: OA
authors.lastname: Fomicheva
authors.forename: M I
authors.initials: MI
authors.lastname: Vil'chinskaia
authors.forename: Z S
authors.initials: ZS
authors.lastname: Alekberova
authors.forename: E N
authors.initials: EN
authors.lastname: Aleksandrova
authors.forename: I A
authors.initials: IA
authors.lastname: Karpov
authors.forename: E L
authors.initials: EL
authors.lastname: Nasonov
authors.forename: O I
authors.initials: OI
authors.lastname: At'kov
mesh_terms: D000293:Adolescent; D000328:Adult; D017152:Antibodies, Antiphospholipid / Q000032:analysis; D016736:Antiphospholipid Syndrome / Q000150:complications* / Q000000981:diagnostic imaging / Q000276:immunology; D018618:Echocardiography, Doppler, Color; D005260:Female; D006349:Heart Valve Diseases / Q000000981:diagnostic imaging / Q000209:etiology* / Q000276:immunology; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D017152:Antibodies, Antiphospholipid