title: [Circadian rhythm of blood pressure and daily hormonal variations].
abstract: As the mortality rate due to cardiovascular complications has increased, knowing the importance of the diurnal cycle of blood pressure, ambulatory blood pressure was recorded in 50 noninsulin-dependent diabetics aged 45 to 65 years. The diurnal cycle of the serum levels of cortisol, prolactin and growth hormone were determined by RIA (radioimmunoassay) method and urinary catechlamines by radioenzymatic method. The obtained results showed significantly higher blood pressure values during sleeping periods in patients with severe hypertension and consequently significantly lower night/day ratio of cortisol and urinary catecholamines as well as increased prolactin. In diabetic patients with autonomic neuropathy blood pressure values were significantly higher during night, but without changes in regard to hormones. It can be concluded that glucocorticoid hormones and catecholamines might be associated with the control of diurnal cycle of blood pressure in patients with severe hypertension.
authors.affiliation: Klinicko-bolnicki centar Dr Dragisa Misovic Beograd.
authors.forename: N
authors.initials: N
authors.lastname: Kostić
authors.forename: S
authors.initials: S
authors.lastname: Secen
mesh_terms: D001794:Blood Pressure; D002395:Catecholamines / Q000652:urine; D002940:Circadian Rhythm; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000378:metabolism / Q000503:physiopathology*; D003929:Diabetic Neuropathies / Q000378:metabolism / Q000503:physiopathology; D005260:Female; D013006:Growth Hormone / Q000097:blood; D006728:Hormones / Q000097:blood*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D006973:Hypertension / Q000150:complications / Q000378:metabolism / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011388:Prolactin / Q000097:blood
chemical_list: D002395:Catecholamines; D006728:Hormones; D011388:Prolactin; D013006:Growth Hormone; D006854:Hydrocortisone