Lipopolysaccharide-induced resistance in mice against ascending urinary tract infection with Klebsiella pneumoniae.
Protective effect of the lipopolysaccharide (LPS) antigen of Klebsiella pneumoniae was tested against ascending-mode urinary tract infection in BALB/c and LACA strains of mice. LPS was given by two different routes; LPS was found to be protective (whatever the application route) since colonization with the challenge organism was significantly lower in both cases as compared with unimmunized mice. A maximum decrease in bacterial count in the kidney of LPS-treated animals was observed on challenge after a 4-d treatment.
Chathley
U C
UC
Department of Microbiology, Panjab University, Chandigarh, India.
Sharma
S
S
Chhibber
S
S
D000276:Adjuvants, Immunologic / Q000494:pharmacology; D000818:Animals; D005260:Female; D007710:Klebsiella Infections / Q000276:immunology / Q000382:microbiology / Q000517:prevention & control*; D007711:Klebsiella pneumoniae / Q000276:immunology / Q000302:isolation & purification; D008070:Lipopolysaccharides / Q000276:immunology / Q000494:pharmacology*; D051379:Mice; D008807:Mice, Inbred BALB C; D013997:Time Factors; D014552:Urinary Tract Infections / Q000276:immunology / Q000382:microbiology / Q000517:prevention & control*
D000276:Adjuvants, Immunologic; D008070:Lipopolysaccharides