C-peptide does not alter carbohydrate metabolism in isolated mouse muscle.
The effects of C-peptide on carbohydrate metabolism in isolated mouse soleus muscle were studied. C-peptide, at concentrations up to 1,000 nM, had no effect on [14C]glucose incorporation into glycogen, glycogen synthase activity, or 2-deoxyglucose uptake. These data demonstrate that C-peptide has no direct effect on the measured parameters of carbohydrate metabolism in isolated mouse muscle.
Shashkin
P N
PN
Division of Clinical Physiology, Department of Surgical Sciences, Karolinska Institute, Karolinska Hospital, Stockholm, Sweden.
Jiao
Y
Y
Westerblad
H
H
Katz
A
A
D000818:Animals; D002096:C-Peptide / Q000494:pharmacology*; D050260:Carbohydrate Metabolism; D003847:Deoxyglucose / Q000493:pharmacokinetics; D006003:Glycogen / Q000096:biosynthesis; D006006:Glycogen Synthase / Q000378:metabolism; D066298:In Vitro Techniques; D007328:Insulin / Q000494:pharmacology; D008297:Male; D051379:Mice; D018482:Muscle, Skeletal / Q000187:drug effects* / Q000378:metabolism*; D009994:Osmolar Concentration; D051381:Rats
D002096:C-Peptide; D007328:Insulin; D006003:Glycogen; D003847:Deoxyglucose; D006006:Glycogen Synthase