Antiinflammatory activity of some medicinal plant extracts form Venezuela.
Six medicinal plant extracts from Venezuela, used in traditional medicine, were investigated for their anti-inflammatory potential against adjuvant-carrageenan-induced inflammation (ACII). All doses expressed here are equivalents of dried starting plant materials (1.50 g dry plant/kg body wt.). The most interesting plant extracts were Synedrella nodiflora, and the hexane leaf extract of Bursera simaruba. In ACII, orally administered extracts (at doses 40 and 80 mg/kg, respectively), inhibited both the acute and chronic phases of this experimental model of inflammation, mainly the chronic phase. These extracts exhibited potent anti-inflammatory activity daily throughout the experiment, and were as effective as reference drugs, phenylbutazone (80 mg/kg) and indomethacin (3 mg/kg).
Abad
M J
MJ
Department of Pharmacology, Faculty of Pharmacy, University of Complutense, Madrid, Spain.
Bermejo
P
P
Carretero
E
E
Martínez-Acitores
C
C
Noguera
B
B
Villar
A
A
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology; D010946:Plants, Medicinal; D051381:Rats; D017207:Rats, Sprague-Dawley; D014687:Venezuela
D000893:Anti-Inflammatory Agents; D010936:Plant Extracts