title: Cca3, the mRNA level of which transiently decreases before initiation of DNA synthesis in regenerating rat liver cells.
abstract: Kinetics of cca1, cca2, cca3 and rat gas1 mRNA levels were compared with those of DNA synthesis level in regenerating rat liver cells after partial hepatectomy. A transient decrease of cca3 mRNA level and an increase of rat gas1 mRNA level were observed before initiation of DNA synthesis, followed by a rapid decrease of rat gas1 mRNA level. By molecular cloning and nucleotide sequencing, cca3 cDNA was found to consist of 4514 nucleotides with a large open reading frame of 3027 nucleotides, encoding a protein of 1009 amino acids with three copies of an ankyrin repeat-like sequence.
authors.affiliation: Laboratory of Viral Oncology, Research Institute, Aichi Cancer Center, Chikusa-ku, Nagoya, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Hayashi
authors.forename: M
authors.initials: M
authors.lastname: Ichinose
authors.forename: H
authors.initials: H
authors.lastname: Yuasa
authors.forename: M
authors.initials: M
authors.lastname: Tatematsu
authors.forename: M
authors.initials: M
authors.lastname: Ishibashi
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D000818:Animals; D019556:COS Cells; D002352:Carrier Proteins; D003094:Collagen; D004261:DNA Replication; D018076:DNA, Complementary; D007700:Kinetics; D008115:Liver Regeneration / Q000235:genetics*; D011506:Proteins / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics*; D051381:Rats
chemical_list: C105542:Abtb2 protein, rat; D048868:Adaptor Proteins, Signal Transducing; C032435:CCA protein, rat; D002352:Carrier Proteins; D018076:DNA, Complementary; D011506:Proteins; D012333:RNA, Messenger; D003094:Collagen