Gingival absorption of triclosan following topical mouthrinse application.
This study assessed the gingival uptake and urinary excretion of triclosan in dogs following topical applications of a mouthrinse containing 0.03% of triclosan. Five different phases were conducted to define the time course of plasma concentration. The effect of plaque on gingival absorption was also measured. Phase I: Animals' teeth were cleaned of plaque via scraping. Blood sampling time was 0-2 hours. Phase II: Plaque was not removed from the animals' teeth. Blood sampling time was 0-2 hours. Phase III: Plaque was not removed from the animals' teeth. Blood sampling time was 0-6 hours. Phase IV: Plaque was not removed from the animals' teeth. Blood sampling time was 0-12 hours. Phase V: Animals' teeth were cleaned of plaque via scraping. Blood sampling time was 0-12 hours. The test substance was administered to 1 male and 1 female dog in Phases I, II, IV and V, and to 1 male dog in Phase III. The same animals were used in each phase. On the first day of each phase, the animals were treated with distilled water for a 15-minute period. The animals were exposed daily to the test material for a 15-minute period during the remaining 7 days of each phase. The test material was administered using custom-made acrylic applicator trays to enclose the maxillar premolars and molars and gingiva of one-half of the upper jaw. A leak-proof seal along the mucogingival junction and palatal mucosa was established and maintained during the exposure period.(ABSTRACT TRUNCATED AT 250 WORDS)
Lin
Y J
YJ
Fung
K K
KK
Kong
B M
BM
DeSalva
S J
SJ
D000704:Analysis of Variance; D000818:Animals; D000891:Anti-Infective Agents, Local / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D003773:Dental Plaque / Q000378:metabolism; D004285:Dogs; D005260:Female; D005881:Gingiva / Q000378:metabolism*; D008297:Male; D009067:Mouthwashes / Q000493:pharmacokinetics*; D013997:Time Factors; D014260:Triclosan / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine
D000891:Anti-Infective Agents, Local; D009067:Mouthwashes; D014260:Triclosan