Transient osteoporosis and osteogenesis imperfecta. A case report.
The authors report migratory transient osteoporsis of the ipsilateral hip and ankle in a patient with ostengenesis imperfecta. The diagnosis was made with modern imaging techniques (magnetic resonance imaging, bone scintigraphy, and dual energy xray absorptiometry). Histologic examination after bone biopsy of the proximal femur showed possible microfractures. The treatment consisted of a regimen of nonweightbearing. One year after onset, the patient had no symptoms and no residual evidence of transient osteoporosis on radiographic studies. The etiology of transient osteoporosis in patients who have osteogenesis imperfecta is uncertain. The authors' findings suggest that microfractures may play a role in the early pathophysiologic process.
Noorda
R J
RJ
Department of Orthopaedic Surgery, Academic Hospital of the Free University, Amsterdam, The Netherlands.
van der Aa
J P
JP
Wuisman
P I
PI
David
E F
EF
Lips
P T
PT
van der Valk
P
P
D001842:Bone and Bones / Q000473:pathology; D005260:Female; D006621:Hip Joint; D006801:Humans; D008875:Middle Aged; D010013:Osteogenesis Imperfecta / Q000150:complications* / Q000175:diagnosis; D010024:Osteoporosis / Q000150:complications* / Q000175:diagnosis