title: Molecular mimicry between Helicobacter pylori and the host.
abstract: Helicobacter pylori lipopolysaccharide (LPS) expresses Lewis x and Lewis y blood group antigens that are identical to those occurring in the human gastric mucosa. During infection, antibodies against LPS, which bind to host Lewis antigens, may be induced. These consequently recognize gastric glycoprotein targets and cause autoimmune inflammation.
authors.affiliation: Dept of Medical Microbiology, Vrije Universiteit, Amsterdam, The Netherlands. bj.appelmelk.mm@med.vu.nl
authors.forename: B J
authors.initials: BJ
authors.lastname: Appelmelk
authors.forename: R
authors.initials: R
authors.lastname: Negrini
authors.forename: A P
authors.initials: AP
authors.lastname: Moran
authors.forename: E J
authors.initials: EJ
authors.lastname: Kuipers
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000096:biosynthesis; D001323:Autoantibodies / Q000096:biosynthesis; D001426:Bacterial Proteins / Q000235:genetics / Q000276:immunology; D005753:Gastric Mucosa / Q000276:immunology; D016481:Helicobacter Infections / Q000209:etiology / Q000276:immunology / Q000473:pathology; D016480:Helicobacter pylori / Q000235:genetics / Q000276:immunology* / Q000472:pathogenicity; D006801:Humans; D007983:Lewis Blood Group Antigens / Q000276:immunology; D008070:Lipopolysaccharides / Q000276:immunology; D051379:Mice; D018716:Molecular Mimicry
chemical_list: D000911:Antibodies, Monoclonal; D001323:Autoantibodies; D001426:Bacterial Proteins; D007983:Lewis Blood Group Antigens; D008070:Lipopolysaccharides