title: Ultrasound biomicroscopic imaging of the anterior aspect of peripheral choroidal melanomas.
abstract: OBJECTIVE
  To correlate ultrasound biomicroscopic features of the anterior aspect of peripheral choroidal melanoma with respect to histopathology.
  
  
  METHODS
  We examined 17 eyes of 17 patients who had clinically diagnosed peripheral choroidal melanomas that approached the ora serrata or extended into the ciliary body and who had been assessed with ultrasound biomicroscopy before enucleation. Comparisons were made between anterior tumor margins imaged by ultrasound biomicroscopy and histopathologic specimens. Anatomic features noted on ultrasound biomicroscopy before enucleation were correlated with enucleation specimens, including supraciliary effusion, rotation of the ciliary body, angle involvement, and internal reflectivity patterns. Anterior tumor margin position was determined with reference to the scleral spur.
  
  
  RESULTS
  Mean distances from the anterior tumor margin to the scleral spur were 1.47 mm on ultrasound biomicroscopy and 1.65 mm on pathologic examination. This difference was not statistically significant (P = .325). Tumor features evident on ultrasound biomicroscopy were also seen on pathologic examination: supraciliary choroidal effusions in seven of seven, ciliary body rotation in seven of eight, and angle involvement in seven of eight. All tumors were mixed-cell melanomas, and 12 of 17 (70%) demonstrated homogeneous ultrasound biomicroscopic internal reflectivity. Irregular internal reflectivity was seen in five of 17 tumors (29%) and was related to prominent internal vascularity on pathology in three of five.
  
  
  CONCLUSIONS
  Ultrasound biomicroscopy is an accurate imaging technique for the in vivo assessment of anterior tumor margins of peripheral choroidal melanomas and can provide detailed imaging of the tumor's interface with the ciliary body.
authors.affiliation: Department of Ophthalmology, Ontario Cancer Institute, Princess Margaret Hospital, University of Toronto, Canada.
authors.forename: D A
authors.initials: DA
authors.lastname: Maberly
authors.forename: C J
authors.initials: CJ
authors.lastname: Pavlin
authors.forename: H D
authors.initials: HD
authors.lastname: McGowan
authors.forename: F S
authors.initials: FS
authors.lastname: Foster
authors.forename: E R
authors.initials: ER
authors.lastname: Simpson
mesh_terms: D000869:Anterior Eye Segment / Q000000981:diagnostic imaging*; D002830:Choroid Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D002924:Ciliary Body / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D008297:Male; D008545:Melanoma / Q000000981:diagnostic imaging* / Q000473:pathology; D008853:Microscopy; D008875:Middle Aged; D009367:Neoplasm Staging; D014463:Ultrasonography