title: Recurrent type III membranoproliferative glomerulonephritis after kidney transplantation.
abstract: The first well-documented case of recurrent type III membranoproliferative glomerulonephritis after kidney transplantation is reported in this article. A 48-year-old man was admitted to the hospital because of nephrotic syndrome and moderate renal failure. The renal biopsy showed double-contour images at light microscopy. Electron microscopy revealed electron-dense deposits in the mesangium and in both the subepithelial and subendothelial sides of the basement membrane. Subepithelial deposits were sometimes hump-like and produced an irregular disruption of the lamina densa. A diagnosis of type III membranoproliferative glomerulonephritis was suggested. The patient had a rapid decrease in renal function and received dialysis in 3 months. Three years later, he received a cadaveric kidney transplant, and subsequently recovered normal renal function. Proteinuria appeared after 13 months, and a biopsy of the graft demonstrated recurrence of the original disease. Seven years after transplantation, he returned to hemodialysis.
authors.affiliation: Department of Nephrology, Hospital Universitario 12 de Octubre, Madrid, Spain.
authors.forename: J M
authors.initials: JM
authors.lastname: Morales
authors.forename: M A
authors.initials: MA
authors.lastname: Martinez
authors.forename: E
authors.initials: E
authors.lastname: Muñoz de Bustillo
authors.forename: M A
authors.initials: MA
authors.lastname: Muñoz
authors.forename: R
authors.initials: R
authors.lastname: Gota
authors.forename: G
authors.initials: G
authors.lastname: Usera
mesh_terms: D001706:Biopsy; D015432:Glomerulonephritis, Membranoproliferative / Q000209:etiology*; D006801:Humans; D007672:Kidney Cortex / Q000473:pathology / Q000648:ultrastructure; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D012008:Recurrence