title: Isochromosome for derivative 17q in acute promyelocytic leukemia: evidence for two copies of PML-RARA and favorable response to all-trans-retinoic acid therapy.
authors.forename: J P
authors.initials: JP
authors.lastname: Park
authors.forename: R B
authors.initials: RB
authors.lastname: Fairweather
authors.forename: T K
authors.initials: TK
authors.lastname: Mohandas
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002886:Chromosomes, Human, Pair 17; D003001:Cloning, Molecular; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D018404:Isochromosomes; D015473:Leukemia, Promyelocytic, Acute / Q000188:drug therapy / Q000235:genetics*; D018168:Receptors, Retinoic Acid / Q000235:genetics; D000072482:Retinoic Acid Receptor alpha; D014212:Tretinoin / Q000627:therapeutic use*
chemical_list: D000970:Antineoplastic Agents; C000607071:RARA protein, human; D018168:Receptors, Retinoic Acid; D000072482:Retinoic Acid Receptor alpha; D014212:Tretinoin