An expanded cohort study of cancer among benzene-exposed workers in China. Benzene Study Group.
An expanded cohort study of 74,828 benzene-exposed and 35,805 unexposed workers were followed during 1972 to 1987, based on a previous study in 12 cities in China. A small increase was observed in total cancer mortality among benzene-exposed compared with unexposed workers (relative risk [RR] = 1.2). Statistically significant excesses were noted for leukemia (RR = 2.3), malignant lymphoma (RR = 4.5), and lung cancer (RR = 1.4). When risks were evaluated by leukemia subtype, only acute myelogenous leukemia was significantly elevated (RR = 3.1), although nonsignificant excesses were also noted for chronic myelogenous leukemia (RR = 2.6) and acute lymphocytic leukemia (RR = 2.3). A significant excess was also found for aplastic anemia.
Yin
S N
SN
Chinese Academy of Preventive Medicine, Bejing, China. yinsn@public3.bta.net.cn
Hayes
R B
RB
Linet
M S
MS
Li
G L
GL
Dosemeci
M
M
Travis
L B
LB
Zhang
Z N
ZN
Li
D G
DG
Chow
W H
WH
Wacholder
S
S
Blot
W J
WJ
D000741:Anemia, Aplastic / Q000139:chemically induced / Q000453:epidemiology; D001554:Benzene / Q000633:toxicity*; D002273:Carcinogens / Q000633:toxicity; D002681:China / Q000453:epidemiology; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007938:Leukemia / Q000139:chemically induced / Q000401:mortality; D015470:Leukemia, Myeloid, Acute / Q000139:chemically induced / Q000401:mortality; D008175:Lung Neoplasms / Q000139:chemically induced / Q000401:mortality; D008223:Lymphoma / Q000139:chemically induced / Q000401:mortality; D008297:Male; D009190:Myelodysplastic Syndromes / Q000139:chemically induced / Q000453:epidemiology; D009369:Neoplasms / Q000139:chemically induced* / Q000401:mortality; D009784:Occupational Diseases / Q000139:chemically induced / Q000453:epidemiology / Q000401:mortality; D016273:Occupational Exposure; D012307:Risk Factors
D002273:Carcinogens; D001554:Benzene