Flutamide photosensitivity.
Flutamide is a non-steroid antiandrogen used in advanced prostate cancer. This drug induces liver toxicity. Other side effects have been reported, especially four cases of photosensitivity. Our patient presented a sun-exposed eruption that disappeared when flutamide was discontinued and relapsed when it was rechallenged. Photopatch tests were negative. UVA MED was much lower during the treatment and the rechallenge of flutamide. The action spectrum of the drug seems to be in the UVA range. According to the literature, this photosensitivity is probably due to a photo-allergic mechanism.
Leroy
D
D
Department of Dermatology of Caen, France.
Dompmartin
A
A
Szczurko
C
C
D000368:Aged; D000726:Androgen Antagonists / Q000009:adverse effects* / Q000627:therapeutic use; D005485:Flutamide / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D010787:Photosensitivity Disorders / Q000139:chemically induced*; D011471:Prostatic Neoplasms / Q000188:drug therapy
D000726:Androgen Antagonists; D005485:Flutamide