title: Radical fringe positions the apical ectodermal ridge at the dorsoventral boundary of the vertebrate limb.
abstract: Vertebrate limb outgrowth requires a structure called the apical ectodermal ridge, formation of which follows the previous establishment of the dorsoventral limb axis. Radical fringe is expressed in the dorsal ectoderm before the ridge appears, and is repressed by Engrailed-1, which is expressed in the ventral ectoderm. Misexpression of these genes indicates that a ridge is formed wherever there is a boundary between cells expressing and not expressing Radical fringe. Thus, as in Drosophila, Radical fringe positions the ridge at the dorsoventral limb boundary.
authors.affiliation: Gene Expression Laboratory, The Salk Institute, La Jolla, California 92037, USA.
authors.forename: C
authors.initials: C
authors.lastname: Rodriguez-Esteban
authors.forename: J W
authors.initials: JW
authors.lastname: Schwabe
authors.forename: J
authors.initials: J
authors.lastname: De La Peña
authors.forename: B
authors.initials: B
authors.lastname: Foys
authors.forename: B
authors.initials: B
authors.lastname: Eshelman
authors.forename: J C
authors.initials: JC
authors.lastname: Izpisúa Belmonte
mesh_terms: D000818:Animals; D030161:Avian Proteins; D005075:Biological Evolution; D019521:Body Patterning / Q000235:genetics / Q000502:physiology; D002642:Chick Embryo; D003001:Cloning, Molecular; D004330:Drosophila / Q000196:embryology; D029721:Drosophila Proteins; D004475:Ectoderm / Q000502:physiology; D004627:Embryonic Induction; D018507:Gene Expression Regulation, Developmental; D005964:Glucosyltransferases; D016695:Glycosyltransferases / Q000235:genetics / Q000378:metabolism; D018398:Homeodomain Proteins / Q000235:genetics; D019476:Insect Proteins / Q000235:genetics / Q000502:physiology; D036341:Intercellular Signaling Peptides and Proteins; D018878:Limb Buds / Q000196:embryology*; D008969:Molecular Sequence Data; D017351:N-Acetylglucosaminyltransferases; D010641:Phenotype; D011506:Proteins / Q000235:genetics / Q000502:physiology*; D011518:Proto-Oncogene Proteins; D012190:Retroviridae / Q000235:genetics; D012689:Sequence Homology, Nucleic Acid; D015398:Signal Transduction; D014921:Wings, Animal / Q000196:embryology; D051153:Wnt Proteins
chemical_list: D030161:Avian Proteins; D029721:Drosophila Proteins; C513076:EN1 protein, human; D018398:Homeodomain Proteins; D019476:Insect Proteins; D036341:Intercellular Signaling Peptides and Proteins; D011506:Proteins; D011518:Proto-Oncogene Proteins; C490509:WNT7A protein, Gallus gallus; D051153:Wnt Proteins; D016695:Glycosyltransferases; D005964:Glucosyltransferases; D017351:N-Acetylglucosaminyltransferases; C491318:RFNG protein, human; C090576:fng protein, Drosophila