[Properties of extracellular products produced by group A streptococci isolated from patient with streptococcal toxic shock syndrome].
Extracellular products of group A streptococci isolated from patients with streptococcal toxic shock syndrome (STSS) examined. The outline of discussion of the 4 products are as follows; Products were streptolysin O (SLO), proteinase, erythrogenic toxin and DNase. SLO showed a large amount of products more than proteinase, erythrogenic toxin and DNase. It should not be concluded that there is a large amount of SLO in the isolated strains from patients with STSS. SLO produced by group A streptococci isolated from the patient with STSS has an isoelectric point (pI) of 6.0 and a molecular weight of 64,000 and shows a hemolytic activity in the presence of 2 mercaptoethanol (2-ME). Furthermore, the hemolytic activities of all components were inhibited by gamma-globulin and cholesterol. These results indicated that all component with hemolytic activity are SLO. These data suggest that STSS does not make up a single syndrome but, rather, that the multiple STSS clinical criteria probably reflects a different characteristic of individual S. pyogenes isolates.
Suzuki
J
J
[Department of Bioorganic Chemistry, College of Environmental Health Azabu University]
Yoshihara
E
E
Kobayashi
S
S
D001426:Bacterial Proteins; D003851:Deoxyribonucleases / Q000302:isolation & purification; D010450:Endopeptidases / Q000302:isolation & purification; D005098:Exotoxins / Q000302:isolation & purification; D006460:Hemolysin Proteins / Q000302:isolation & purification; D006801:Humans; D008565:Membrane Proteins; D012772:Shock, Septic / Q000382:microbiology*; D013290:Streptococcal Infections / Q000382:microbiology*; D013297:Streptococcus pyogenes / Q000302:isolation & purification* / Q000378:metabolism*; D013301:Streptolysins / Q000302:isolation & purification
D001426:Bacterial Proteins; D005098:Exotoxins; D006460:Hemolysin Proteins; D008565:Membrane Proteins; C117980:SpeA protein, Streptococcus pyogenes; D013301:Streptolysins; C027951:erythrogenic toxin; C025964:streptolysin O; D003851:Deoxyribonucleases; D010450:Endopeptidases