Dialysis culture enables more accurate determination of MIC of benzylpenicillin for Borrelia burgdorferi than does conventional procedure.
A constant benzylpenicillin (penicillin G) concentration for determination of the MIC for strains of Borrelia burgdorferi was achieved by dialysis culture. The strains were grown in dialysis membrane bags with daily transfer to tubes with freshly added benzylpenicillin. The MICs decreased by one or several dilution steps compared with the conventional procedure.
Stiernstedt
S H
SH
Karolinska Institutet, Department of Infectious Diseases, Danderyd, Sweden.
Wretlind
B
B
D015748:Borrelia burgdorferi Group / Q000187:drug effects*; D008826:Microbial Sensitivity Tests / Q000379:methods; D010400:Penicillin G / Q000494:pharmacology*; D010406:Penicillins / Q000494:pharmacology*
D010406:Penicillins; D010400:Penicillin G