Evidence for independent hypertensive effects of oxytocin and vasopressin in the rat dorsal vagal complex.
Infusion of OT or the V1 agonist [Phe2,Orn8]-vasotocin (POVT) (50 ng) into the dorsal vagal complex of urethane-anaesthetized male rats induced a sustained hypertension. Simultaneous infusion of the V1 antagonist d(CH2)5[Tyr(Me)2]-VP blocked the effect of POVT, but not of OT. The OT antagonist d(CH2)5[Tyr(Me)2,Thr4,Orn8,Tyr-NH(9)2]-vasotocin blocked the effect of OT, but not of POVT. The OT agonist [Thr4,Gly7]-OT had no effect. This suggests that OT-induced hypertension involves mechanisms independent of V1 and uterine-type OT receptors.
Tian
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PS
Department of Anatomy, University of Bristol, UK.
Ingram
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CD
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D004347:Drug Interactions; D008297:Male; D010121:Oxytocin / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D014630:Vagus Nerve / Q000187:drug effects* / Q000502:physiology; D014667:Vasopressins / Q000494:pharmacology*
D014667:Vasopressins; D010121:Oxytocin