title: No evidence of association between dopamine D3 receptor gene and bipolar affective disorder.
abstract: A recent study reported a possible association between allele 1 of the dopamine D3 receptor gene and bipolar affective disorder using the haplotype relative risk approach. In attempt to replicate these findings, we used similar family-based methods, such as the Haplotype-Based Haplotype Relative Risk method and the Transmission Disequilibrium Test, in a sample of 44 bipolar probands from Sardinia with both parents available. Using the Bal I restriction enzyme site polymorphism of Lannfelt et al. (1992), no differences were found between transmitted and non-transmitted alleles and no evidence of linkage disequilibrium was observed.
authors.affiliation: Department of Neurosciences B.B. Brodie, University of Cagliari, Italy.
authors.forename: M P
authors.initials: MP
authors.lastname: Piccardi
authors.forename: G
authors.initials: G
authors.lastname: Severino
authors.forename: A
authors.initials: A
authors.lastname: Bocchetta
authors.forename: M A
authors.initials: MA
authors.lastname: Palmas
authors.forename: S
authors.initials: S
authors.lastname: Ruiu
authors.forename: M
authors.initials: M
authors.lastname: Del Zompo
mesh_terms: D000483:Alleles; D001714:Bipolar Disorder / Q000235:genetics*; D005838:Genotype; D006239:Haplotypes; D006579:Heterozygote; D006801:Humans; D015810:Linkage Disequilibrium; D011110:Polymorphism, Genetic; D017448:Receptors, Dopamine D2 / Q000235:genetics*; D050637:Receptors, Dopamine D3
chemical_list: C493593:DRD3 protein, human; D017448:Receptors, Dopamine D2; D050637:Receptors, Dopamine D3