Some derivatives of 3-amino-2-oxazolidinone influencing neurotransmission of dopamine and serotonin.
The influence of 3-amino-2-oxazolidinone derivatives 1-9 on dopaminergic and serotoninergic neurotransmission was tested. It was found that all tested compounds exhibited modulating activity on one (or both) of the neurotransmissions, the effect being dependent on the aromatic ring substituent.
Chilmonczyk
Z
Z
Pharmaceutical Research Institute, Warsaw, Poland.
Krzywda
J
J
Cybulski
J
J
Iskra-Jopa
J
J
D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism; D000818:Animals; D004298:Dopamine / Q000378:metabolism / Q000502:physiology; D015259:Dopamine Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D005260:Female; D010134:Fenclonine / Q000494:pharmacology; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D008297:Male; D051379:Mice; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology; D010081:Oxazolone / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000494:pharmacology; D010293:Pargyline / Q000494:pharmacology; D016548:Prosencephalon / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012701:Serotonin / Q000378:metabolism / Q000502:physiology; D018490:Serotonin Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D009435:Synaptic Transmission / Q000187:drug effects*
D015259:Dopamine Agents; D008996:Monoamine Oxidase Inhibitors; D018490:Serotonin Agents; D015102:3,4-Dihydroxyphenylacetic Acid; D010081:Oxazolone; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D010293:Pargyline; D010134:Fenclonine; D004298:Dopamine