Effect of glycine on antidepressant- and anxiolytic-like action of 1-aminocyclopropanecarboxylic acid (ACPC) in rats.
Glycine (800 mg/kg ip) abolished the antimmobility effect of 1-aminocyclopropanecarboxylic acid (ACPC) given both ip (400 mg/kg) and ihp (30 micrograms) in the forced swimming test in rats, but did not affect the anticonflict activity of ACPC (200 mg/kg ip or 10 micrograms ihp) in the conflict drinking test.
Chojnacka-Wójcik
E
E
Department of New Drug Research, Polish Academy of Sciences, Kraków, Poland.
Tatarczyńska
E
E
Dereń-Wesołek
A
A
D000596:Amino Acids / Q000008:administration & dosage / Q000633:toxicity*; D000598:Amino Acids, Cyclic; D000818:Animals; D014151:Anti-Anxiety Agents / Q000633:toxicity*; D000928:Antidepressive Agents / Q000633:toxicity*; D004195:Disease Models, Animal; D005998:Glycine / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D007274:Injections, Intraperitoneal; D008297:Male; D010805:Physical Conditioning, Animal; D051381:Rats; D017208:Rats, Wistar
D000596:Amino Acids; D000598:Amino Acids, Cyclic; D014151:Anti-Anxiety Agents; D000928:Antidepressive Agents; C023863:1-aminocyclopropane-1-carboxylic acid; D005998:Glycine