Molecular biological intervention.
Molecular biological intervention including gene therapy is a novel form of molecular medicine that will have an impact on the treatment of many serious diseases. Recent advancement in understanding of molecular mechanism of human disease and development of gene technology allows us practical approaches to molecular biological intervention. In addition to the possibility of correcting inherited genetic disorders, molecular biological intervention is being used to combat acquired disease. In the field of nephrology, the basic study has started on the gene transfer into the kidney in vivo. This review describes some approaches and methods that may be used for molecular biological intervention for glomerulonephritis and the state of our preclinical studies targeting transforming growth factor-beta.
Isaka
Y
Y
First Department of Medicine, Osaka University School of Medicine, Japan.
Imai
E
E
D000818:Animals; D002478:Cells, Cultured; D018014:Gene Transfer Techniques; D015316:Genetic Therapy / Q000379:methods* / Q000639:trends; D005921:Glomerulonephritis / Q000235:genetics / Q000628:therapy*; D006801:Humans; D007678:Kidney Glomerulus / Q000473:pathology / Q000503:physiopathology; D008967:Molecular Biology / Q000379:methods