Neurotransmitter receptor/G-protein mediated signal transduction in Alzheimer's disease brain.
Recent evidence suggests that the neurochemical pathology of Alzheimer's disease includes severe disruptions of the neurotransmitter receptor/G-protein mediated phosphatidylinositol hydrolysis and adenylyl cyclase signal transduction pathways. The present article briefly reviews evidence from postmortem studies describing disruptions to these systems and speculates as to the importance of these changes in terms of contributing to disease pathology and limiting the success of neurotransmitter replacement strategies.
Cowburn
R F
RF
Alzheimer's Disease Research Centre, Karolinska Institute, Department of Clinical Neuroscience and Family Medicine, NOVUM, Huddinge, Sweden.
Fowler
C J
CJ
O'Neill
C
C
D000544:Alzheimer Disease / Q000378:metabolism*; D001921:Brain / Q000378:metabolism*; D019204:GTP-Binding Proteins / Q000502:physiology*; D006801:Humans; D017981:Receptors, Neurotransmitter / Q000502:physiology*; D015398:Signal Transduction
D017981:Receptors, Neurotransmitter; D019204:GTP-Binding Proteins