title: Pyridindolols K1 and K2, new alkaloids from Streptomyces sp. K93-0711.
abstract: Two new alkaloids with the beta-carboline skeleton, pyridindolols K1 (C18H18N2O5) and K2 (C16H16N2O4), were isolated from the culture both of Streptomyces sp. K93-0711. The structure of pyridindolols were established by spectroscopic investigations and chemical transformations. Pyridindolol K2 inhibited the adhesion of HL-60 cells to LPS-activated HUVEC monolayer (IC50 = 75 micrograms/ml).
authors.affiliation: Kitasato Institute, Tokyo, Japan.
authors.forename: Y P
authors.initials: YP
authors.lastname: Kim
authors.forename: S
authors.initials: S
authors.lastname: Takamatsu
authors.forename: M
authors.initials: M
authors.lastname: Hayashi
authors.forename: K
authors.initials: K
authors.lastname: Komiyama
authors.forename: S
authors.initials: S
authors.lastname: Omura
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D002243:Carbolines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018922:HL-60 Cells / Q000187:drug effects; D006801:Humans; D051379:Mice; D013302:Streptomyces / Q000737:chemistry*
chemical_list: D000470:Alkaloids; D002243:Carbolines; C106432:pyridindolol K1; C106433:pyridindolol K2; C010774:pyridindolol