Mig, the monokine induced by interferon-gamma, promotes tumor necrosis in vivo.
Mig, the monokine induced by interferon-gamma, is a CXC chemokine active as a chemoattractant for activated T cells. Mig is related functionally to interferon-inducible protein 10 (IP-10), with which it shares a receptor, CXCR3. Previously, IP-10 was found to have antitumor activity in vivo. In the present study, murine Mig RNA was found to be expressed at higher levels in regressing Burkitt's lymphoma tumors established in nude mice compared with progressively growing tumors. Daily inoculations of purified recombinant human Mig into Burkitt's tumors growing subcutaneously in nude mice consistently caused tumor necrosis associated with extensive vascular damage. These effects were indistinguishable from those produced by intratumor inoculations of Burkitt's tumors with IP-10. These results support the notion that Mig, like IP-10, has antitumor activity in vivo.
Sgadari
C
C
Center for Biologics Evaluation and Research, Bethesda, MD 20892, USA.
Farber
J M
JM
Angiolillo
A L
AL
Liao
F
F
Teruya-Feldstein
J
J
Burd
P R
PR
Yao
L
L
Gupta
G
G
Kanegane
C
C
Tosato
G
G
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001808:Blood Vessels / Q000473:pathology; D002051:Burkitt Lymphoma / Q000188:drug therapy* / Q000473:pathology; D016466:CHO Cells; D054357:Chemokine CXCL10; D054370:Chemokine CXCL9; D018925:Chemokines / Q000096:biosynthesis / Q000235:genetics / Q000494:pharmacology / Q000627:therapeutic use*; D019743:Chemokines, CXC; D006224:Cricetinae; D003412:Cricetulus; D016207:Cytokines / Q000096:biosynthesis / Q000235:genetics / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D009336:Necrosis; D009363:Neoplasm Proteins / Q000096:biosynthesis / Q000235:genetics; D009368:Neoplasm Transplantation; D016133:Polymerase Chain Reaction; D011994:Recombinant Proteins / Q000494:pharmacology / Q000627:therapeutic use; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; C080810:CXCL9 protein, human; D054357:Chemokine CXCL10; D054370:Chemokine CXCL9; D018925:Chemokines; D019743:Chemokines, CXC; D016207:Cytokines; D036341:Intercellular Signaling Peptides and Proteins; D009363:Neoplasm Proteins; D011994:Recombinant Proteins