Kidney bean and soybean lectins cause enzyme secretion by pancreatic acini in vitro.
The responses of pancreas acini from Hooded-Lister rats to kidney bean E2L2 lectin or soybean agglutinin have been studied in vitro. Both lectins induced secretion of alpha-amylase from acini in a dose dependent manner. However, the concentrations of lectin required to cause enzyme secretion were approximately 14-fold higher than that necessary with CCK-8. In addition, the responsiveness of pancreas acini to lectins in vitro was significantly altered by the age and sex of the rats from which the acini were derived.
Grant
G
G
Rowett Research Institute, Aberdeen, Scotland, UK. G.Grant@rri.sari.ac.uk
Henderson
L T
LT
Edwards
J E
JE
Ewan
E C
EC
Bardocz
S
S
Pusztai
A
A
D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D066298:In Vitro Techniques; D037102:Lectins / Q000494:pharmacology*; D008297:Male; D010179:Pancreas / Q000187:drug effects / Q000201:enzymology*; D010835:Phytohemagglutinins / Q000494:pharmacology*; D037121:Plant Lectins; D051381:Rats; D012844:Sincalide / Q000494:pharmacology; D030262:Soybean Proteins; D000516:alpha-Amylases / Q000378:metabolism*
D037102:Lectins; D010835:Phytohemagglutinins; D037121:Plant Lectins; D030262:Soybean Proteins; C028824:soybean lectin; D000516:alpha-Amylases; D012844:Sincalide