title: Immunopathogenesis of canine aural haematoma.
abstract: Data are presented from 15 dogs with aural haematoma. The series included six Labrador retrievers and four golden retrievers and the mean age was 8.0 +/- 3.02 years. Five dogs had evidence of pruritic skin disease and five further cases had other concurrent disease. Haematology and serum biochemistry were normal in 12 and 13 of the 15 dogs, respectively. All dogs were Coombs' negative and serum antinuclear antibody had negative or low titres in all the 11 cases tested. Histopathological examination of biopsies from the affected ears revealed variable degrees of erosion of auricular cartilage with fibrovascular granulation tissue filling the cartilage defects. There was minimal perichondral inflammation. The biopsies were studied by immunohistochemistry for deposition of immunoglobulin G (IgG), immunoglobulin M (IgM) and complement C3. In one dog there was basement membrane zone deposition of IgG and in another there was focal interepithelial deposition of both IgG and IgM. The findings of this study do not support an autoimmune pathogenesis for canine aural haematoma, but suggest that an early immunological event may underlie the observed cartilage erosion.
authors.affiliation: Croft Veterinary Surgeons, Blyth Northumberland.
authors.forename: J A
authors.initials: JA
authors.lastname: Joyce
authors.forename: M J
authors.initials: MJ
authors.lastname: Day
mesh_terms: D000818:Animals; D000974:Antibodies, Antinuclear / Q000032:analysis; D001327:Autoimmune Diseases / Q000209:etiology / Q000276:immunology / Q000662:veterinary; D001706:Biopsy / Q000379:methods / Q000662:veterinary; D015932:Complement C3c / Q000032:analysis; D003298:Coombs Test / Q000379:methods / Q000662:veterinary; D004283:Dog Diseases / Q000209:etiology* / Q000276:immunology* / Q000473:pathology; D004285:Dogs; D004425:Ear Cartilage / Q000737:chemistry / Q000276:immunology / Q000473:pathology; D004427:Ear Diseases / Q000209:etiology / Q000276:immunology / Q000662:veterinary*; D004431:Ear, External / Q000737:chemistry / Q000276:immunology / Q000473:pathology*; D004817:Epidermis / Q000737:chemistry / Q000276:immunology / Q000473:pathology; D005260:Female; D005455:Fluorescent Antibody Technique / Q000379:methods / Q000662:veterinary; D006406:Hematoma / Q000209:etiology / Q000276:immunology / Q000662:veterinary*; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D008297:Male
chemical_list: D000974:Antibodies, Antinuclear; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D015932:Complement C3c