title: Regional eruptive neurofibromas.
abstract: A 71-year-old woman presented with multiple, flesh-colored, papular lesions on the left dorsal side of the hand which had erupted 5 years earlier. No cafè-au-lait spots, freckles, or Lisch nodules were detected. Family history did not disclose neurofibromas or abnormal pigmentation. Two biopsy specimens of the lesions showed circumscribed, non-encapsulated neurofibromas. Segmental neurofibromatosis is characterized by the unilateral, segmental appearance of neurofibromas and/or cafè-au-lait spots in the absence of genetic transmission. The authors discuss the significance of localized multiple cutaneous neurofibromas in the absence of family history and suggest the possibility of a cutaneous hamartoma.
authors.affiliation: Clinica Dermatologica IV, Università degli Studi di Milano, Ospedale S. Paolo, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Betti
authors.forename: A
authors.initials: A
authors.lastname: Cerri
authors.forename: L
authors.initials: L
authors.lastname: Gualandri
authors.forename: L
authors.initials: L
authors.lastname: Moneghini
authors.forename: C
authors.initials: C
authors.lastname: Crosti
mesh_terms: D000368:Aged; D005260:Female; D006225:Hand; D006801:Humans; D017253:Neurofibromatoses / Q000473:pathology*; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000473:pathology*