title: Subcortical hyperintensities on MRI and activities of daily living in geriatric depression.
abstract: Data from 30 elderly inpatients with major depression were analyzed to explore the relationship between subcortical hyperintensities (SH) on MRI and activities of daily living (ADLs). A comparison of subjects based on a median split of the severity of SH revealed that subjects with greater SH performed worse on both instrumental and physical ADLs. A hierarchical multiple regression revealed that age, depression severity, neuropsychological test performance, and SH variables accounted for a total of 53% of the variance in ADL functioning. Severity of SH accounted for an additional 18% of the variance over and above the other three variables. Results suggest that severity of subcortical disease measured by MRI improves prediction of functional impairment in elderly individuals.
authors.affiliation: Butler Hospital, Providence, RI 02906, USA.
authors.forename: D A
authors.initials: DA
authors.lastname: Cahn
authors.forename: P F
authors.initials: PF
authors.lastname: Malloy
authors.forename: S
authors.initials: S
authors.lastname: Salloway
authors.forename: J
authors.initials: J
authors.lastname: Rogg
authors.forename: E
authors.initials: E
authors.lastname: Gillard
authors.forename: R
authors.initials: R
authors.lastname: Kohn
authors.forename: G
authors.initials: G
authors.lastname: Tung
authors.forename: E D
authors.initials: ED
authors.lastname: Richardson
authors.forename: R
authors.initials: R
authors.lastname: Westlake
mesh_terms: D000203:Activities of Daily Living; D000368:Aged; D003866:Depressive Disorder / Q000503:physiopathology*; D005260:Female; D005625:Frontal Lobe / Q000503:physiopathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests