title: Growth hormone-producing pituitary tumours: clinical profile and results of surgery.
abstract: BACKGROUND
  Growth hormone-producing pituitary tumours present with a wide variety of manifestations. The optimum diagnostic work up, management and follow up of such patients is complex and involves a multidisciplinary approach. There is paucity of data from India with regard to the clinical presentation and results of surgery for growth hormone-producing tumours.
  
  
  METHODS
  We studied the first 50 patients presenting during 1989-94 with growth hormone-producing pituitary tumours to our centre. The work up included detailed endocrine and radiological assessment. The surgical outcome was analysed for 35 patients who were operated (trans-sphenoidal 29, transcranial 6) at our centre.
  
  
  RESULTS
  All the patients had macroadenomas [mean (SD) diameter 3.12 (0.87) cm]. Seventy-five per cent of the patients had supra- and/or parasellar extension and 57% had visual field defects. Tumour size correlated with the preoperative basal (r = 0.57) and glucose-suppressed (r = 0.54) growth hormone levels. Thirty-three of the 35 patients operated at our centre (trans-sphenoidal 28, transcranial 5) were available for follow up (median duration 34 months). After trans-sphenoidal surgery alone, 12 of the 28 (43%) patients had normalization of growth hormone levels (post-glucose growth hormone < 5 ng/ml), and 9 of 11 (82%) showed improvement in visual fields.
  
  
  CONCLUSIONS
  In India, growth hormone-producing pituitary tumours are usually large in size. The growth hormone levels correlate with the size of the tumour. These tumours can be effectively treated by trans-sphenoidal or transcranial surgery.
authors.affiliation: Department of Endocrinology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.
authors.forename: K D
authors.initials: KD
authors.lastname: Modi
authors.forename: A
authors.initials: A
authors.lastname: Mithal
authors.forename: D
authors.initials: D
authors.lastname: Banerji
authors.forename: D
authors.initials: D
authors.lastname: Kumar
authors.forename: P
authors.initials: P
authors.lastname: Shah
authors.forename: V K
authors.initials: VK
authors.lastname: Jain
authors.forename: D K
authors.initials: DK
authors.lastname: Chhabra
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D019382:Human Growth Hormone / Q000096:biosynthesis*; D006801:Humans; D008875:Middle Aged; D010911:Pituitary Neoplasms / Q000000981:diagnostic imaging / Q000378:metabolism / Q000601:surgery*; D014057:Tomography, X-Ray Computed
chemical_list: D019382:Human Growth Hormone