The influence of postantibiotic effects and postantibiotic effects of sub-inhibitory concentrations of quinolones and aminoglycosides on phospholipase C of Pseudomonas aeruginosa.
We have studied the postantibiotic effect (PAE) and postantibiotic sub-MICs effect (PA SME) of ciprofloxacin, pefloxacin, netilmicin and tobramycin on the production of phospholipase C (PLC) in a Pseudomonas aeruginosa strain isolated from clinical material. All antibiotics tested (postantibiotic phase evoked by 2.MIC) reduced the production of PLC, particularly pefloxacin to 13.2%. The PA phase evoked by 4.MIC of quinolones did not cause regrowth of P. aeruginosa and aminoglycosides inhibited PLC, in particular with tobramycin to 16.9%. The effect of PA SME (2.MIC) of netilmicin and tobramycin inhibited PLC more expressively (< 20%) than ciprofloxacin; pefloxacin did not allow regrowth. PA SMEs of the antibiotics tested reduced the production of PLC more effectively than PAE.
Hybenová
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Institute of Preventive and Clinical Medicine, Bratislava, Slovak Republic.
Majtán
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V
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000890:Anti-Infective Agents / Q000494:pharmacology*; D002939:Ciprofloxacin / Q000494:pharmacology; D005839:Gentamicins / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D009428:Netilmicin / Q000494:pharmacology; D015366:Pefloxacin / Q000494:pharmacology; D011550:Pseudomonas aeruginosa / Q000187:drug effects / Q000201:enzymology*; D014031:Tobramycin / Q000494:pharmacology; D010738:Type C Phospholipases / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D005839:Gentamicins; D015366:Pefloxacin; D009428:Netilmicin; D002939:Ciprofloxacin; D010738:Type C Phospholipases; D014031:Tobramycin