title: IgG subclasses of human autoantibodies.
abstract: IgG comprises of four subclasses which differ from each other with respect to their biological properties. Fc gamma receptor shedding as well as a variety of T cell cytokines are influential in the distribution of these subclasses, but the route the antigen is introduced into the body is also important. With regard to nonorgan-specific autoimmune conditions, such as rheumatoid arthritis and systemic lupus erythematosus, IgG1 and IgG3 autoantibodies predominate, whereas IgG4 antibodies are regularly encountered in organ-specific autoimmune diseases. This suggests that the target organ may be continuously stimulating the immune system.
authors.affiliation: Department of Medicine 'B', Chaim Sheba Medical Center, Tel-Hashomer, Israel.
authors.forename: R
authors.initials: R
authors.lastname: Maran
authors.forename: M
authors.initials: M
authors.lastname: Dueymes
authors.forename: R
authors.initials: R
authors.lastname: Le Corre
authors.forename: Y
authors.initials: Y
authors.lastname: Renaudineau
authors.forename: Y
authors.initials: Y
authors.lastname: Shoenfeld
authors.forename: P
authors.initials: P
authors.lastname: Youinou
mesh_terms: D001323:Autoantibodies / Q000145:classification* / Q000502:physiology; D001327:Autoimmune Diseases / Q000276:immunology; D002462:Cell Membrane / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000145:classification* / Q000502:physiology; D007239:Infections / Q000276:immunology
chemical_list: D001323:Autoantibodies; D007074:Immunoglobulin G