ATP-regulated K+ channel in mitochondria: pharmacology and function.
Mitochondria from several tissues contain a potassium-specific channel similar to the ATP-regulated K+ (K ATP) channel of the plasma membrane. The mitochondrial channel shares with the plasma membrane K ATP channel the sensitivity to sulfonylurea derivatives and some other blockers as well as to channel openers of diverse chemical character. In contrast to the plasma membrane channel, which is blocked by free ATP, the mitochondrial K ATP channel reconstituted into liposomes requires the ATP-Mg complex for inhibition. The mitochondrial K ATP channel, possibly in a concerted action with other K+ permeability pathways, plays an important role in mitochondrial volume control. Its function in the regulation of the components of the protonmotive force is also suggested.
Szewczyk
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A
Nencki Institute of Experimental Biology, Poland.
Czyz
A
A
Wojcik
G
G
Wojtczak
L
L
Nalecz
M J
MJ
D000227:Adenine Nucleotides / Q000494:pharmacology; D000255:Adenosine Triphosphate / Q000378:metabolism* / Q000494:pharmacology; D000818:Animals; D004734:Energy Metabolism; D006801:Humans; D066298:In Vitro Techniques; D008564:Membrane Potentials; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism*; D026902:Potassium Channel Blockers; D015221:Potassium Channels / Q000187:drug effects / Q000378:metabolism*; D013453:Sulfonylurea Compounds / Q000494:pharmacology
D000227:Adenine Nucleotides; D026902:Potassium Channel Blockers; D015221:Potassium Channels; D013453:Sulfonylurea Compounds; D000255:Adenosine Triphosphate