Prophylactic treatment of migraine with gamma-linolenic and alpha-linolenic acids.
Polyunsaturated fatty acids (PUFA) were administered to 168 patients over a period of 6 months in an open-label uncontrolled study. In 129 patients available for study, 86% experienced reduction in severity, frequency and duration of migraine attacks, 22% became free of migraine and more than 90% had reduced nausea and vomiting. Self-medication changed to simple analgesics in the majority except in 14% of patients without improvement.
Wagner
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W
Department of Anesthesiology, Municipal Hospital of Zehlendorf, Free University of Berlin, Germany.
Nootbaar-Wagner
U
U
D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D008881:Migraine Disorders / Q000188:drug therapy* / Q000517:prevention & control; D017962:alpha-Linolenic Acid / Q000627:therapeutic use*; D017965:gamma-Linolenic Acid / Q000627:therapeutic use*
D017962:alpha-Linolenic Acid; D017965:gamma-Linolenic Acid