Relation between torsion and cross-sectional area change in the human left ventricle.
During the ejection phase, motion of the left ventricular (LV) wall is such that all myocardial fibers shorten to the same extent. In a mathematical model of LV mechanisms it was found that this condition could be satisfied only if torsion around the long axis followed a unique function of the ratio of cavity volume to wall volume. When fiber shortening becomes non-uniform due to cardiac pathology, this pathology may be reflected in aberration of the torsional motion pattern. In the present study we investigated whether the predicted regular motion pattern could be found in nine healthy volunteers, using Magnetic Resonance Tagging. In two parallel short-axis cross-sections, displacement, rotation, and area ejection were derived from the motion of tags, attached non-invasively to the myocardium. Information from both sections was combined to determine area ejection, quantified as the change in the logarithm of the ratio of cavity area to wall area, and torsion, represented by the shear angle on the epicardium. Linear regression was applied to torsion as a function of area ejection. The slope thus found (-0.173 +/- 0.024 rad, mean +/- S.D.) was similar to the slope as predicted by the model of LV mechanics (-0.194 +/- 0.026 rad). In conclusion, the relation between area ejection and torsion could be assessed noninvasively in humans. In healthy volunteers, the relation was close to what was predicted by a mathematical model of LV mechanics, and also close to what was found earlier in experiments on animals.
Aelen
F W
FW
Department of Biophysics, Cardiovascular Research Institute Maastricht, Maastricht University, The Netherlands.
Arts
T
T
Sanders
D G
DG
Thelissen
G R
GR
Muijtjens
A M
AM
Prinzen
F W
FW
Reneman
R S
RS
D000465:Algorithms; D005544:Forecasting; D006331:Heart Diseases / Q000473:pathology / Q000503:physiopathology; D006352:Heart Ventricles / Q000033:anatomy & histology; D006801:Humans; D016014:Linear Models; D008279:Magnetic Resonance Imaging; D008955:Models, Cardiovascular; D018485:Muscle Fibers, Skeletal / Q000648:ultrastructure; D009200:Myocardial Contraction; D009206:Myocardium / Q000648:ultrastructure; D010496:Pericardium / Q000033:anatomy & histology / Q000502:physiology; D012399:Rotation; D013318:Stroke Volume; D016276:Ventricular Function