Adenoviral transfection of canine islet xenografts with immunosuppressive cytokine genes abrogates primary nonfunction and prolongs graft survival.
Deng
S
S
Department of Surgery, University of Pennsylvania Medical Center, Philadelphia 19104, USA.
Ketchum
R J
RJ
Kucher
T
T
Weber
M
M
Shaked
A
A
Naji
A
A
Brayman
K L
KL
D000256:Adenoviridae; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D016207:Cytokines / Q000096:biosynthesis* / Q000235:genetics; D003921:Diabetes Mellitus, Experimental / Q000628:therapy*; D004285:Dogs; D005822:Genetic Vectors; D006085:Graft Survival; D006801:Humans; D007165:Immunosuppression Therapy / Q000379:methods*; D016753:Interleukin-10 / Q000096:biosynthesis; D016381:Islets of Langerhans Transplantation / Q000276:immunology / Q000502:physiology*; D051379:Mice; D008819:Mice, Nude; D051381:Rats; D011917:Rats, Inbred Lew; D014162:Transfection; D016212:Transforming Growth Factor beta / Q000096:biosynthesis; D014183:Transplantation, Heterologous / Q000276:immunology*
D001786:Blood Glucose; D016207:Cytokines; D016212:Transforming Growth Factor beta; D016753:Interleukin-10