Growth in the diabetic child.
Insulin has an important role in the GH:IGF-I axis, and its absence leads to major endocrine disturbances, particularly during puberty. Rapid growth in the prediabetic phase occurs and may be a risk factor. Final height reflects gender and the age of onset more than specific growth factors. The influence of hepatic insulin on IGF-I bioactivity has important implications in diabetic adolescents.
Connors
M H
MH
Department of Pediatrics, University of California, Davis Medical Center, Sacramento, USA.
D000293:Adolescent; D017668:Age of Onset; D001827:Body Height; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000150:complications*; D006130:Growth Disorders / Q000209:etiology*; D013006:Growth Hormone / Q000502:physiology; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000502:physiology; D011627:Puberty; D012307:Risk Factors; D012727:Sex Characteristics
D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone