Interaction of a herbomineral preparation D-400, with oral hypoglycaemic drugs.
D-400, a herbomineral preparation has proven antidiabetic activity in experimental models as well as in clinical trials. The possibility of concomitant use of this drug with sulphonylureas was explored in animal models. D-400 has been investigated for its interaction with oral hypoglycaemic agents namely, tolbutamide and glibenclamide in alloxan-induced diabetic rabbits. Administration of D-400 at a dose of 1 g/kg for 15 days significantly elevated plasma tolbutamide and glibenclamide concentrations with simultaneous reduction of blood glucose. Plasma tolbutamide and glibenclamide concentrations were significantly lowered after withdrawal of D-400 treatment. Elevation of plasma concentration of tolbutamide was observed only for the first 4 h after which it declined towards normal levels and no significant difference between D-400 treated and control group was observed at the end of 8 h. Significant elevation of plasma glibenclamide levels was observed at 2, 4 and 8 h with D-400 treatment. Incubation of D-400 with tolbutamide in plasma resulted in a significant increase in free tolbutamide levels.
Sundaram
R
R
R and D Centre, Himalaya Drug Co., Bangalore, India.
Venkataranganna
M V
MV
Gopumadhavan
S
S
Mitra
S K
SK
D000496:Alloxan; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy; D004347:Drug Interactions; D005905:Glyburide / Q000097:blood; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology*; D011817:Rabbits
D001786:Blood Glucose; C095293:D 400; D007004:Hypoglycemic Agents; D010936:Plant Extracts; D000496:Alloxan; D005905:Glyburide