title: Frequency of gastroesophageal reflux events induced by pharyngeal water stimulation in young and elderly subjects.
abstract: Earlier studies have shown that isolated complete lower esophageal sphincter (LES) relaxation occurs as a result of pharyngeal water stimulation. Association of these relaxations with gastroesophageal reflux has not been studied systematically. Our aim was to determine this association in young and elderly subjects during precibal and postprandial periods. We studied 8 young subjects and 10 elderly subjects for 1 h before and 2 h after a 1,000-cal meal. In both groups, during the precibal period, negligible LES relaxation induced by pharyngeal water stimulation resulted in gastroesophageal reflux. In the postprandial period, gastroesophageal reflux events occurred after 16% of pharyngeal water injections in young subjects and after 44% in elderly subjects (P < 0.05). Intraabdominal length of the LES in elderly subjects was significantly shorter compared with younger subjects (P < 0.05). We conclude that gastroesophageal reflux events induced by pharyngeal water stimulation in the postprandial period are significantly increased compared with those of the precibal period and are significantly more prevalent in the elderly compared with the young. These differences seem to be associated with a significantly shorter intra-abdominal segment of the LES in the elderly.
authors.affiliation: First Teaching Hospital, Beijing Medical University, People's Republic of China.
authors.forename: P
authors.initials: P
authors.lastname: Xie
authors.forename: J
authors.initials: J
authors.lastname: Ren
authors.forename: E
authors.initials: E
authors.lastname: Bardan
authors.forename: R K
authors.initials: RK
authors.lastname: Mittal
authors.forename: Z
authors.initials: Z
authors.lastname: Sui
authors.forename: R
authors.initials: R
authors.lastname: Shaker
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging / Q000502:physiology*; D004435:Eating; D004943:Esophagogastric Junction / Q000503:physiopathology; D004947:Esophagus / Q000378:metabolism; D005260:Female; D005764:Gastroesophageal Reflux / Q000503:physiopathology*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008365:Manometry; D009126:Muscle Relaxation / Q000502:physiology; D010614:Pharynx / Q000503:physiopathology*; D010812:Physical Stimulation; D014867:Water / Q000494:pharmacology*
chemical_list: D014867:Water