title: [Time-related effect of betapressin+ in patients with essential hypertension stage II].
abstract: Time-related effect of betapressin (penbutolol) has been studied in 24 patients with essential hypertension stage II. The drug was given in the morning, afternoon and evening in a dose 40 mg. Control group consisted of 20 patients with essential hypertension stage II on betapressin at a mean daily dose 108.4 +/- 6.25 mg. Pre- and posttreatment hemodynamic parameters were registered at tetrapolar chest rheography. Arterial pressure was measured according to N.S. Korotkov. In the study group the parameters were taken 6 times a day each 4 hours before and after the treatment course. The course lasted for 20 days on the average in both groups. The study discovered time-related effect of betapressin; negative chronotropic effect in the morning and evening, negative inotropic effect in the day time. The hypotensive effect varied with the day hour being the highest in the single administration.
authors.affiliation: City Clinic Hospital No 60, Moscow.
authors.forename: R M
authors.initials: RM
authors.lastname: Zaslavskaia
authors.forename: G V
authors.initials: GV
authors.lastname: Lilitsa
authors.forename: K Z
authors.initials: KZ
authors.lastname: Akhmetov
authors.forename: M M
authors.initials: MM
authors.lastname: Teiblium
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage*; D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D019454:Chronotherapy / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D010394:Penbutolol / Q000008:administration & dosage*; D010992:Plethysmography, Impedance
chemical_list: D000319:Adrenergic beta-Antagonists; D010394:Penbutolol