Post-transplant EBV induced lymphoproliferative disorders.
Epstein Barr virus induced lymphoproliferative disease (EBV-LPD) is a heterogeneous disorder, ranging from polyclonal lymphoproliferations to malignant lymphoma, typically seen in individuals with inadequate cellular immunity to EBV. The diagnosis of EBV-LPD following transplant requires a high index of suspicion in those patients at risk. Unlike organ transplant patients, in whom lymphomas are generally of host origin and respond to decreases in immunosuppression, bone marrow transplant recipients have donor origin tumors that are not as responsive to conservative treatment modalities. For the latter group, adoptive immunotherapy with donor lymphocytes is the treatment of choice and generally results in complete eradication of these tumors. Whether adoptive immunotherapy can be used for EBV-LPD in patients following organ transplantation is currently being investigated.
Lucas
K G
KG
Department of Pediatrics, Riley Hospital for Children, Indiana University, Indianapolis 46202-5225, USA.
Pollok
K E
KE
Emanuel
D J
DJ
D016026:Bone Marrow Transplantation / Q000276:immunology; D006566:Herpesviridae Infections / Q000276:immunology*; D004854:Herpesvirus 4, Human / Q000472:pathogenicity*; D006801:Humans; D007111:Immunity, Cellular; D008232:Lymphoproliferative Disorders / Q000382:microbiology* / Q000628:therapy; D016377:Organ Transplantation; D014181:Transplantation Immunology