Effects of ionomer cement on guinea pig cochleas.
The inner ear toxicity of ionomeric cement (Ionocem) when used as a reconstructive material in ear surgery was evaluated in 47 guinea pigs used in a morphological study. The cement was implanted on either the promontory, the round window membrane or the stapes. There was no significant hair cell loss compared with the control ear at three weeks, two months or three months after implantation. Using electrocochleography, the hearing thresholds before, and three weeks, two and three months after the implantation were compared in an additional seven animals. No evident hearing loss was observed in any animal during the study period. No morphological or functional evidence for an ototoxic effect of the ionomeric cement was found in this study.
Kobayashi
T
T
Department of Otolaryngology, Ehime University School of Medicine, Japan.
Hinohira
Y
Y
Hyodo
M
M
Bredberg
G
G
Alsterborg
E
E
D000538:Aluminum Silicates / Q000633:toxicity*; D000818:Animals; D001309:Auditory Threshold; D001672:Biocompatible Materials; D003051:Cochlea / Q000187:drug effects* / Q000473:pathology / Q000601:surgery; D004195:Disease Models, Animal; D005899:Glass Ionomer Cements / Q000633:toxicity*; D006168:Guinea Pigs; D006198:Hair Cells, Auditory / Q000187:drug effects* / Q000648:ultrastructure; D010036:Otolaryngology / Q000379:methods; D016896:Treatment Outcome
D000538:Aluminum Silicates; D001672:Biocompatible Materials; D005899:Glass Ionomer Cements; C088058:polymaleinate ionomer