title: Kidney bean and soybean lectins cause enzyme secretion by pancreatic acini in vitro.
abstract: The responses of pancreas acini from Hooded-Lister rats to kidney bean E2L2 lectin or soybean agglutinin have been studied in vitro. Both lectins induced secretion of alpha-amylase from acini in a dose dependent manner. However, the concentrations of lectin required to cause enzyme secretion were approximately 14-fold higher than that necessary with CCK-8. In addition, the responsiveness of pancreas acini to lectins in vitro was significantly altered by the age and sex of the rats from which the acini were derived.
authors.affiliation: Rowett Research Institute, Aberdeen, Scotland, UK. G.Grant@rri.sari.ac.uk
authors.forename: G
authors.initials: G
authors.lastname: Grant
authors.forename: L T
authors.initials: LT
authors.lastname: Henderson
authors.forename: J E
authors.initials: JE
authors.lastname: Edwards
authors.forename: E C
authors.initials: EC
authors.lastname: Ewan
authors.forename: S
authors.initials: S
authors.lastname: Bardocz
authors.forename: A
authors.initials: A
authors.lastname: Pusztai
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D066298:In Vitro Techniques; D037102:Lectins / Q000494:pharmacology*; D008297:Male; D010179:Pancreas / Q000187:drug effects / Q000201:enzymology*; D010835:Phytohemagglutinins / Q000494:pharmacology*; D037121:Plant Lectins; D051381:Rats; D012844:Sincalide / Q000494:pharmacology; D030262:Soybean Proteins; D000516:alpha-Amylases / Q000378:metabolism*
chemical_list: D037102:Lectins; D010835:Phytohemagglutinins; D037121:Plant Lectins; D030262:Soybean Proteins; C028824:soybean lectin; D000516:alpha-Amylases; D012844:Sincalide