title: Q fever in pregnancy.
abstract: We describe a case of acute symptomatic infection with Coxiella burnetii acquired between the 16th and 28th week of pregnancy. Oral ciprofloxacin therapy was started on diagnosis, at the 28th week of pregnancy, but symptoms were unabated after 3 weeks treatment, suggesting persisting infection of the products of conception. Caesarean section was therefore performed at 32 weeks gestation when a healthy infant was delivered, and subsequent investigations showed no evidence of transplacental spread of infection. Infection control measures were applied at the time of delivery to minimize the risk of infection to obstetricians and midwives from potentially infectious products of conception.
authors.affiliation: Clinical Microbiology and Public Health Laboratory, Addenbrooke's NHS Trust, Cambridge, U.K.
authors.forename: H
authors.initials: H
authors.lastname: Ludlam
authors.forename: T G
authors.initials: TG
authors.lastname: Wreghitt
authors.forename: S
authors.initials: S
authors.lastname: Thornton
authors.forename: B J
authors.initials: BJ
authors.lastname: Thomson
authors.forename: N J
authors.initials: NJ
authors.lastname: Bishop
authors.forename: S
authors.initials: S
authors.lastname: Coomber
authors.forename: J
authors.initials: J
authors.lastname: Cunniffe
mesh_terms: D000328:Adult; D000890:Anti-Infective Agents / Q000627:therapeutic use; D002585:Cesarean Section; D002939:Ciprofloxacin / Q000627:therapeutic use; D005260:Female; D006801:Humans; D017053:Infection Control; D017758:Infectious Disease Transmission, Patient-to-Professional / Q000517:prevention & control; D009774:Obstetrics; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000175:diagnosis / Q000188:drug therapy; D011778:Q Fever / Q000175:diagnosis / Q000188:drug therapy / Q000635:transmission
chemical_list: D000890:Anti-Infective Agents; D002939:Ciprofloxacin