A discussion of activity-dependent forms of synaptic weakening and their possible role in ocular dominance plasticity.
Activity-dependent synaptic weakening is likely to be involved in numerous types of developmentally regulated cortical plasticity. The possible roles of two models of synaptic weakening, homosynaptic- and heterosynaptic-long-term-depression (LTD), are discussed. Metabotropic glutamate receptors (mGluRs) as they relate to LTD and ocular dominance plasticity will also be considered.
Dudek
S M
SM
NICHD, National Institutes of Health, Bethesda, MD 20892-4480, USA.
D000818:Animals; D007839:Functional Laterality / Q000502:physiology; D009473:Neuronal Plasticity / Q000502:physiology*; D018094:Receptors, Metabotropic Glutamate / Q000502:physiology; D012683:Sensory Deprivation / Q000502:physiology*; D013569:Synapses / Q000502:physiology*; D015357:Vision Disparity / Q000502:physiology*; D015349:Vision, Monocular / Q000502:physiology*; D014795:Visual Pathways / Q000254:growth & development / Q000502:physiology
D018094:Receptors, Metabotropic Glutamate