Hippocampal atrophy secondary to entorhinal cortical degeneration in Alzheimer-type dementia.
Pathological comparison between cases with Alzheimer-type dementia (ATD) and the non-demented cases with infarct showed that hippocampal atrophy in ATD could be caused mainly by degeneration of the stratum lacunosum-radiatum rather than neuronal loss in the pyramidal layer of the hippocampus, and that degeneration of the stratum lacunosum-radiatum could be secondary mainly to the entorhinal cortical degeneration.
Mizutani
T
T
Department of Neuropathology, Tokyo Metropolitan Institute of Gerontology, Japan.
Kasahara
M
M
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000473:pathology*; D001284:Atrophy; D018728:Entorhinal Cortex / Q000473:pathology*; D005260:Female; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D009410:Nerve Degeneration / Q000502:physiology*