title: Using aspects of study design in sample size estimation.
abstract: The basis of sample size calculations is usually needed in protocols for clinical trials and when publishing results in respected journals. Although a large amount of research has been undertaken on sample size estimation for different trial designs, in practice the methods are rarely used. This paper describes some useful theory that has practical relevance.
authors.affiliation: Wyeth Research, Berkshire, UK.
authors.forename: A
authors.initials: A
authors.lastname: Phillips
authors.forename: M
authors.initials: M
authors.lastname: Campbell
mesh_terms: D002986:Clinical Trials as Topic / Q000706:statistics & numerical data*; D003198:Computer Simulation; D011338:Probability Theory; D016032:Randomized Controlled Trials as Topic / Q000706:statistics & numerical data; D012107:Research Design; D018401:Sample Size; D013810:Therapeutic Equivalency