Inhaled nitric oxide in burn patients with respiratory failure.
BACKGROUND
Inhaled nitric oxide (NO) has the potential to improve ventilation/perfusion matching and decrease pulmonary artery pressure in patients with profound respiratory failure.


METHODS
Eight patients, average age of 35 years (range, 2.5-77 years) and burn size 49% (range, 19-80%), with inhalation injury and respiratory failure failing conventional management (average Pao2/FiO2 ratio (PFR) 85) were given inhaled NO at 20 ppm.


RESULTS
An immediate mean increase in PFR of 10% and a decrease in pulmonary artery mean pressure of 7.8% was noted. At 24 hours, the average improvement in PFR was 28% and that in pulmonary artery mean pressure was 7.7%. Although not reaching statistical significance, these changes were more pronounced in those patients who went on to survive. There was no hypotension attributed to NO administration, and maximum methemoglobin levels averaged 0.9%.


CONCLUSIONS
Inhaled NO can be safely administered to selected burn patients with severe respiratory failure who are perceived to be failing conventional support. Although current data are not adequate to support its general use, an immediate and sustained improvement in PFR and pulmonary artery mean pressure may correlate with eventual recovery of pulmonary function. Continued evaluation in controlled settings seems warranted and is in progress.
Sheridan
R L
RL
Surgical Service, Massachusetts General Hospital, Boston, USA.
Hurford
W E
WE
Kacmarek
R M
RM
Ritz
R H
RH
Yin
L M
LM
Ryan
C M
CM
Tompkins
R G
RG
D000280:Administration, Inhalation; D000293:Adolescent; D000328:Adult; D000368:Aged; D002059:Burns, Inhalation / Q000150:complications*; D002648:Child; D002675:Child, Preschool; D016903:Drug Monitoring; D006801:Humans; D008875:Middle Aged; D009569:Nitric Oxide / Q000627:therapeutic use*; D011669:Pulmonary Wedge Pressure / Q000187:drug effects; D012131:Respiratory Insufficiency / Q000188:drug therapy* / Q000209:etiology* / Q000401:mortality / Q000503:physiopathology; D016019:Survival Analysis; D014692:Ventilation-Perfusion Ratio / Q000187:drug effects
D009569:Nitric Oxide