[Combination chemotherapy with total or subtotal lymphatic irradiation in the treatment of lymphogranulomatosis, stage IIIA or IIIB (based on five- and ten-year results)].
High rates of overall and recurrence-free 5- and 10-year survival were recorded in 561 patients with Hodgkin's disease (stage IIIA-IIIAE and IIIB-IIIBE) after combination therapy using 2-4 cycles of MOPP, MOPP/ABV, COPP, DOPP or DOPP/ABV polychemotherapy, with radiation treatment being reduced to subtotal irradiation of lymph collectors. Total 5- and 10-year survival for stage IIIA was 96.8 and 91.5 and recurrence-free survival-81.2 and 81.2%, respectively: for stage IIIB-90.7; 83.2 and 68.6; 56.6%, respectively.
Kanaev
S V
SV
Gershanovich
M L
ML
Malinin
A P
AP
D000293:Adolescent; D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D005260:Female; D005500:Follow-Up Studies; D006689:Hodgkin Disease / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011879:Radiotherapy Dosage; D018714:Radiotherapy, Adjuvant; D016019:Survival Analysis; D016896:Treatment Outcome