[Preparation and evaluation of solid dispersions of pilocarpine hydrochloride for alleviation of xerostomia].
This investigation was carried out to try the application of pilocarpine hydrochloride (PC) solid dispersion as sustained release dosage form. Four preparations of PC with ethylcellulose and/or hydroxypropylmethylcellulose phthalate were prepared by the organic solvent method. The preparation D including PC: ethylcellulose: hydroxypropylmethylcellulose phthalate (1:9:10 at weight ratio) showed the best sustained release behavior in dissolution test among four preparations. The preparation D was examined by powder X-ray diffractometry and differential scanning calorimetry, and confirmed to be solid dispersion. Saliva secretory effect of preparation D was examined in healthy male volunteers, and its effect for Xerostomia was showed.
Oda
M
M
Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Japan.
Sato
M
M
Yagi
N
N
Ohno
K
K
Miyazaki
S
S
Watanabe
S
S
Takada
M
M
D002482:Cellulose / Q000031:analogs & derivatives; D003692:Delayed-Action Preparations; D004304:Dosage Forms; D006801:Humans; D065347:Hypromellose Derivatives; D008297:Male; D008747:Methylcellulose / Q000031:analogs & derivatives; D010862:Pilocarpine / Q000494:pharmacology*; D012463:Saliva / Q000378:metabolism*; D013268:Stimulation, Chemical; D014987:Xerostomia / Q000188:drug therapy*
D003692:Delayed-Action Preparations; D004304:Dosage Forms; D010862:Pilocarpine; D065347:Hypromellose Derivatives; C013517:ethyl cellulose; D002482:Cellulose; D008747:Methylcellulose