Pemphigoid nodularis: a report of three cases and review of the literature.
Many variants of bullous pemphigoid have been reported, some of which are clinically very atypical. One of the rarest variants is pemphigoid nodularis. We report three patients with this distinct entity. In all three cases patients initially presented with prurigo-like lesions and in one case nodular lesions preceded the onset of blistering by many months. Direct immunofluorescence was positive in all cases, with linear basement membrane zone deposition of IgG and C3. Circulating IgG antibasement membrane antibody was detected in two cases, and in these two patients on salt-split immuno-fluorescence the antibodies bound to the roof of the bullae.
Cliff
S
S
Department of Dermatology, St Helier Hospital, Surrey, U.K.
Holden
C A
CA
D000368:Aged; D000369:Aged, 80 and over; D004817:Epidermis / Q000276:immunology*; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis*; D008297:Male; D010391:Pemphigoid, Bullous / Q000276:immunology* / Q000473:pathology; D012867:Skin / Q000473:pathology
D007074:Immunoglobulin G