title: Successful reversal of acute vascular rejection in a renal allograft with combined mycophenolate mofetil and tacrolimus as primary immunotherapy.
abstract: Despite the use of newer immunosuppressive drugs, early allograft rejection is still a major cause of graft loss and diminished graft survival. The pathological picture of acute interstitial rejection usually responds to high dose steroids, whereas the treatment of acute vascular (AVR) rejection characterized by an intense vasculitis and/or endotheliolitis is more formidable. The use of newer monoclonal antibodies specific for T lymphocytes and their subsets has only been occasionally successful in reversing AVR. Here we report a case of successful reversal of acute vascular renal allograft rejection with mycophenolate mofetil (MMF) and tacrolimus as primary therapy.
authors.affiliation: Department of Medicine, Milton S. Hershey Medical Center, Pennsylvania State University-College of Medicine, Hershey 17033, USA.
authors.forename: N
authors.initials: N
authors.lastname: Ahsan
authors.forename: M J
authors.initials: MJ
authors.lastname: Holman
authors.forename: D A
authors.initials: DA
authors.lastname: Katz
authors.forename: C S
authors.initials: CS
authors.lastname: Abendroth
authors.forename: H C
authors.initials: HC
authors.lastname: Yang
mesh_terms: D000328:Adult; D004359:Drug Therapy, Combination; D005260:Female; D006084:Graft Rejection / Q000188:drug therapy*; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage*; D007668:Kidney / Q000098:blood supply; D016030:Kidney Transplantation; D009173:Mycophenolic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives*; D016559:Tacrolimus / Q000008:administration & dosage*
chemical_list: D007166:Immunosuppressive Agents; D009173:Mycophenolic Acid; D016559:Tacrolimus