title: Syncope: the diagnostic value of head-up tilt testing.
abstract: To determine the usefulness of prolonged head-up tilt in the diagnosis of neurally mediated syncope, 201 patients with history of syncope of unknown cause and 102 age and gender matched control subjects underwent a 40 minute 60 degrees head-up tilt test. Head-up tilt elicited syncope (i.e., was positive) in 74 of the 201 patients (37%) with a history of unexplained syncope and in only 6 of the 102 controls (6%). The specificity of the test was 100% in patients 60 years of age and older. Symptoms during tilt-induced syncope were identified by the patients as similar to those they had suffered during their spontaneous episodes. All 80 subjects who had tilt-induced syncope recovered without sequelae. The positive predictive value of a positive responses to head-up tilt was 93% and the negative predictive value was 43%. The results indicate that the prolonged head-up tilt test is a very specific procedure of high diagnostic value in patients with a history of unexplained syncope. It is particularly useful in the elderly age groups who have a high incidence of syncope.
authors.affiliation: Department of Neurology, Mount Sinai School of Medicine of the City University of New York, New York, USA.
authors.forename: E
authors.initials: E
authors.lastname: Oribe
authors.forename: S
authors.initials: S
authors.lastname: Caro
authors.forename: R
authors.initials: R
authors.lastname: Perera
authors.forename: S L
authors.initials: SL
authors.lastname: Winters
authors.forename: J A
authors.initials: JA
authors.lastname: Gomes
authors.forename: H
authors.initials: H
authors.lastname: Kaufmann
mesh_terms: D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D013575:Syncope / Q000175:diagnosis* / Q000209:etiology; D018667:Tilt-Table Test