Primary cutaneous coccidioidomycosis and subsequent drug eruption to itraconazole in a dog.
Three weeks after traveling to Arizona, a 13-month-old, female Labrador retriever developed draining tracts in the right hind limb. Primary cutaneous coccidioidomycosis was diagnosed. Initial treatment with itraconazole resulted in exacerbation of clinical signs. Histopathology was suggestive of a cutaneous drug eruption. Discontinuation of the itraconazole caused resolution of the drug eruption. Successful treatment of the fungal infection was achieved using ketoconazole.
Plotnick
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Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins 80523-1620, USA.
Boshoven
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Rosychuk
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RA
D000818:Animals; D000935:Antifungal Agents / Q000009:adverse effects* / Q000627:therapeutic use; D003047:Coccidioidomycosis / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D004283:Dog Diseases / Q000139:chemically induced* / Q000188:drug therapy* / Q000473:pathology; D004285:Dogs; D003875:Drug Eruptions / Q000209:etiology / Q000473:pathology / Q000662:veterinary*; D005260:Female; D017964:Itraconazole / Q000009:adverse effects* / Q000627:therapeutic use; D007654:Ketoconazole / Q000627:therapeutic use; D008198:Lymph Nodes / Q000473:pathology; D012867:Skin / Q000473:pathology
D000935:Antifungal Agents; D017964:Itraconazole; D007654:Ketoconazole