title: In vitro and in vivo effects of leflunomide, brequinar, and cyclosporine on pyrimidine biosynthesis.
authors.affiliation: Department of Cardiothoracic Surgery, Transplantation Immunology, Stanford University School of Medicine, California 94305-5247, USA.
authors.forename: H T
authors.initials: HT
authors.lastname: Silva
authors.forename: W
authors.initials: W
authors.lastname: Cao
authors.forename: R A
authors.initials: RA
authors.lastname: Shorthouse
authors.forename: M
authors.initials: M
authors.lastname: Löffler
authors.forename: R E
authors.initials: RE
authors.lastname: Morris
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001713:Biphenyl Compounds / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D016572:Cyclosporine / Q000494:pharmacology*; D000090722:Dihydroorotate Dehydrogenase; D016027:Heart Transplantation / Q000276:immunology / Q000502:physiology*; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D007555:Isoxazoles / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D000077339:Leflunomide; D008213:Lymphocyte Activation / Q000187:drug effects*; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D009963:Orotic Acid / Q000494:pharmacology; D010088:Oxidoreductases / Q000378:metabolism*; D044925:Oxidoreductases Acting on CH-CH Group Donors; D011743:Pyrimidines / Q000096:biosynthesis*; D051381:Rats; D014184:Transplantation, Homologous; D014529:Uridine / Q000494:pharmacology; D011798:Quinaldines
chemical_list: D001713:Biphenyl Compounds; D016572:Cyclosporine; D000090722:Dihydroorotate Dehydrogenase; D007166:Immunosuppressive Agents; D007555:Isoxazoles; D000077339:Leflunomide; D009963:Orotic Acid; D010088:Oxidoreductases; D044925:Oxidoreductases Acting on CH-CH Group Donors; D011743:Pyrimidines; D014529:Uridine; C046943:brequinar; D011798:Quinaldines