title: [Local intra-arterial thrombolysis. Results in arterial thromboses and graft occlusions].
abstract: The purpose of this study was to evaluate the efficacy of intraarterial low-dose recombinant tissue plasminogen activator (rt-PA) in patients with acute or subacute thrombosis of the native arterial system or in an arterial artificial or venous by-pass graft. Twenty patients with 22 cases of thrombosis received intraarterial thrombolysis during the period 1.1.1995 to 31.12.1995. Ten patients (50%) achieved complete radiological thrombolysis, and in seven patients (35%) partial thrombolysis was achieved. Half of these patients required a subsequent PTA or an operation. There were only three patients (15%) where no lysis occurred. The results seemed very satisfactory and we conclude that thrombolysis should be considered as the first-choice treatment in this category of patients. The indications may be extended to patients with critical ischaemia with the introduction of the pulse-spray technique as the time to complete lysis is considerably shorter with this technique.
authors.affiliation: Hjerte-lunge-karkirurgisk afdeling T, Skejby Sygehus, Arhus.
authors.forename: A K
authors.initials: AK
authors.lastname: Hansen
authors.forename: M R
authors.initials: MR
authors.lastname: Egeblad
authors.forename: A
authors.initials: A
authors.lastname: Klaerke
mesh_terms: D005069:Evaluation Studies as Topic; D006083:Graft Occlusion, Vascular / Q000188:drug therapy*; D006801:Humans; D007269:Injections, Intra-Arterial; D010960:Plasminogen Activators / Q000008:administration & dosage*; D012189:Retrospective Studies; D015912:Thrombolytic Therapy / Q000379:methods*; D013927:Thrombosis / Q000188:drug therapy*; D010959:Tissue Plasminogen Activator / Q000008:administration & dosage*
chemical_list: D010960:Plasminogen Activators; D010959:Tissue Plasminogen Activator