mGluR1 mutant mice as a tool to study calcium signalling and multiple innervation in the cerebellum.
The present study reports that calcium signalling through voltage-gated calcium channels and release from internal stores is impaired in Purkinje cells of mutant mice lacking in GluR1 receptors and that the absence of these receptors also leads to an incomplete regression of multiple innervation in the cerebellum of these animals.
Daniel
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H
Laboratoire de Neurobiologie, CNRS, Orsay, France.
Levenes
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C
Conquet
F
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Crépel
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D000818:Animals; D015220:Calcium Channels / Q000502:physiology*; D066298:In Vitro Techniques; D008564:Membrane Potentials / Q000502:physiology; D051379:Mice; D008817:Mice, Mutant Strains; D009412:Nerve Fibers / Q000502:physiology*; D009473:Neuronal Plasticity / Q000502:physiology; D018408:Patch-Clamp Techniques; D011597:Psychomotor Performance / Q000502:physiology*; D011689:Purkinje Cells / Q000502:physiology*; D018094:Receptors, Metabotropic Glutamate / Q000172:deficiency*; D015398:Signal Transduction / Q000502:physiology*
D015220:Calcium Channels; D018094:Receptors, Metabotropic Glutamate; C104077:metabotropic glutamate receptor type 1