title: Intrapulmonary Mycobacterium avium infection as the first manifestation of chronic granulomatous disease.
abstract: A 10-month-old Japanese male infant, with no history of being prone to infections, contracted an intrapulmonary mycobacterial infection. After 2 months of intermittent fever, radiological examinations revealed mass lesions in the lung and mediastinum. Biopsy specimens showed granulomas with caseous necrosis, from which Mycobacterium avium was isolated. There was no history of mycobacteriosis or immunodeficiency diseases among his relatives. Analyses of the O2- release and expression of NADPH oxidase components verified that he suffered from gp91-phox- chronic granulomatous disease (CGD), and that his mother was a carrier of the disease. This is a rare clinical presentation for the onset of CGD, suggesting that the invasive mycobacteriosis might result from defective intracellular killing of CGD-phagocytes.
authors.affiliation: Department of Pediatrics, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Ohga
authors.forename: K
authors.initials: K
authors.lastname: Ikeuchi
authors.forename: R
authors.initials: R
authors.lastname: Kadoya
authors.forename: K
authors.initials: K
authors.lastname: Okada
authors.forename: C
authors.initials: C
authors.lastname: Miyazaki
authors.forename: S
authors.initials: S
authors.lastname: Suita
authors.forename: K
authors.initials: K
authors.lastname: Ueda
mesh_terms: D006105:Granulomatous Disease, Chronic / Q000150:complications / Q000175:diagnosis*; D006801:Humans; D007223:Infant; D008297:Male; D015269:Mycobacterium avium Complex; D015270:Mycobacterium avium-intracellulare Infection / Q000209:etiology*; D019255:NADPH Oxidases / Q000172:deficiency; D009504:Neutrophils / Q000201:enzymology; D016897:Respiratory Burst
chemical_list: D019255:NADPH Oxidases