title: Effect of ketoconazole 2% shampoo on scalp sebum level in patients with seborrhoeic dermatitis.
abstract: Twenty patients with scalp seborrhoeic dermatitis were treated twice weekly with ketoconazole 2% shampoo for 4 weeks. Clinical assessment, culture for P. ovale on Dixon broth and lipid measurement at two places were made before treatment and after 2 and 4 weeks. Significant improvement of the severity of seborrhoeic dermatitis (p < 0.001) and negative mycological tests by 19 (95%) of patients were observed. The scalp lipid content remained unaltered in 11 patients with an initial lipid value over 220 micrograms/cm2 but increased in those with lower initial values. This is probably due to the improvement of sebum delivery onto skin surface as a result of the elimination of the follicular occlusion.
authors.affiliation: Department of Dermatology, Medical University, Plovdiv, Bulgaria.
authors.forename: H
authors.initials: H
authors.lastname: Dobrev
authors.forename: L
authors.initials: L
authors.lastname: Zissova
mesh_terms: D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D012628:Dermatitis, Seborrheic / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology; D005260:Female; D006203:Hair Preparations; D006801:Humans; D007654:Ketoconazole / Q000627:therapeutic use*; D008290:Malassezia / Q000187:drug effects / Q000302:isolation & purification; D008297:Male; D012535:Scalp; D016896:Treatment Outcome
chemical_list: D006203:Hair Preparations; D007654:Ketoconazole