Alleviation of the peripheral hemodynamic effects of dexmedetomidine by the calcium channel blocker isradipine.
BACKGROUND
Alpha 2-adrenergic agonists have peripheral vasoconstrictive effects and central sympatholytic and sedative effects. Whereas the latter are the basis of their use in anesthesia, the former could limit their clinical application.


METHODS
To study whether a vasodilator could alleviate the systemic and coronary vasoconstrictor effects of dexmedetomidine without influencing the central sympatholytic effects, the calcium channel blocker isradipine was infused after a high dose of dexmedetomidine in anesthetized dogs.


RESULTS
Dexmedetomidine 10 micrograms.kg-1 decreased plasma concentrations of norepinephrine and epinephrine by more than 90%, heart rate by 39%, cardiac output by 64%, dp/dtmax by 29% and increased mean arterial pressure by 55% and the left ventricular end-diastolic pressure (LVEDP) 4-fold as compared to baseline. In addition, coronary blood flow decreased by 52% and coronary venous oxygen saturation by 51%. Isradipine could completely antagonize all the coronary and systemic hemodynamic changes induced by dexmedetomidine, but only partially he increase in LVEDP. Isradipine caused no changes in plasma catecholamine levels.


CONCLUSIONS
Isradipine could alleviate the peripheral hemodynamic actions of dexmedetomidine while having no effect on its central sympatholytic properties.
Roekaerts
P M
PM
Department of Anesthesiology, University Hospital of Maarstricht, The Nederlands.
Lawrence
C J
CJ
Prinzen
F W
FW
de Lange
S
S
D000316:Adrenergic alpha-Agonists / Q000494:pharmacology*; D018712:Analgesics, Non-Narcotic / Q000494:pharmacology*; D000758:Anesthesia; D018685:Anesthetics, Inhalation; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D002302:Cardiac Output / Q000187:drug effects; D002395:Catecholamines / Q000097:blood; D003326:Coronary Circulation / Q000187:drug effects; D004285:Dogs; D006221:Halothane; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D007093:Imidazoles / Q000494:pharmacology*; D017275:Isradipine / Q000494:pharmacology*; D020926:Medetomidine; D014665:Vasodilator Agents / Q000494:pharmacology
D000316:Adrenergic alpha-Agonists; D018712:Analgesics, Non-Narcotic; D018685:Anesthetics, Inhalation; D002121:Calcium Channel Blockers; D002395:Catecholamines; D007093:Imidazoles; D014665:Vasodilator Agents; D020926:Medetomidine; D006221:Halothane; D017275:Isradipine