title: Open randomised trial of prescribing strategies in managing sore throat.
abstract: OBJECTIVE
  To assess three prescribing strategies for sore throat.
  
  
  METHODS
  Randomised follow up study.
  
  
  METHODS
  11 general practices in the South and West region.
  
  
  METHODS
  716 patients aged 4 years and over with sore throat and an abnormal physical sign in the throat; 84% had tonsillitis or pharyngitis. Patients were randomised to three groups: prescription for antibiotics for 10 days (group 1,246 patients); no prescription (group 2,230 patients); or prescription for antibiotics if symptoms were not starting to settle after three days (group 3; 238 patients).
  
  
  METHODS
  Duration of symptoms; satisfaction and compliance with and perceived efficacy of antibiotics; time off school or work. Outcomes were documented in 582 subjects (81%).
  
  
  RESULTS
  Median duration of antibiotic use differed significantly in the three groups (10 v 0 v 0 days, P < 0.001); 69% of patients in group 3 did not use their prescription. The proportion of patients better by day 3 did not differ significantly (37% v 35% v 30%, P = 0.28), nor did the duration of illness (median 4 v 5 v 5 days, P = 0.39), days off work or school (median 2 v 2 v 1, P = 0.13), or proportion of patients satisfied (96% v 90% v 93%, P = 0.09), although group 1 had fewer days of fever (median 1 v 2 v 2 days, P = 0.04). More patients in group 1 thought the antibiotics were effective (87% v 55% v 60%, P < 0.001) and intended coming to the doctor in future attacks (79% v 54% v 57%, P < 0.001). "Legitimation" of illness-to explain to work or school (60%) or family or friends (37%)-was an important reason for consultation. Patients who were more satisfied got better more quickly, and satisfaction related strongly to how well the doctor dealt with patient's concerns.
  
  
  CONCLUSIONS
  Prescribing antibiotics for sore throat only marginally affects the resolution of symptoms but enhances belief in antibiotics and intention to consult in future when compared with the acceptable strategies of no prescription or delayed prescription. Psychosocial factors are important in the decision to see a general practitioner and in predicting the duration of illness.
authors.affiliation: Primary Medical Care, Faculty of Health, Medicine, and Biological Sciences, Aldermoor Health Centre, Southampton University.
authors.forename: P
authors.initials: P
authors.lastname: Little
authors.forename: I
authors.initials: I
authors.lastname: Williamson
authors.forename: G
authors.initials: G
authors.lastname: Warner
authors.forename: C
authors.initials: C
authors.lastname: Gould
authors.forename: M
authors.initials: M
authors.lastname: Gantley
authors.forename: A L
authors.initials: AL
authors.lastname: Kinmonth
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001294:Attitude to Health; D002648:Child; D002675:Child, Preschool; D004363:Drug Utilization / Q000706:statistics & numerical data*; D005194:Family Practice / Q000706:statistics & numerical data*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010349:Patient Compliance; D017060:Patient Satisfaction; D010612:Pharyngitis / Q000188:drug therapy* / Q000209:etiology; D010818:Practice Patterns, Physicians'; D015983:Selection Bias; D014069:Tonsillitis / Q000188:drug therapy* / Q000209:etiology
chemical_list: D000900:Anti-Bacterial Agents