Medial olivocochlear efferent system in humans studied with amplitude-modulated tones.
Evoked otoacoustic emissions (EOAEs) are assumed to be generated by outer hair cells (OHCs). It is now generally accepted that EOAEs represent a means of functional exploration of the active micromechanical properties of OHCs. Efferent fibers of the medial olivocochlear system (MOCS) are connected along the sides and the bases of OHCs. Some studies have shown that a suppression effect on EOAE amplitude is induced by the MOCS neurons during contralateral stimulation, presumably by modification of OHC motility. The contralateral acoustic stimuli used in experiments on the EOAE suppression effect have consisted mainly of sounds without a slow temporal fluctuation in their envelopes (broad-band noise, narrow-band noise, pure tones, or clicks). To elucidate further the parameters of MOCS activation, in the present study we looked at the contralateral suppression effect of amplitude-modulated (AM) tones. The results showed that EOAE amplitude was reduced with AM tones compared with no contralateral acoustic stimulation. The suppression effect mainly depended on three parameters. 1) Contralateral stimulation intensity: EOAE suppression occurred only with intensities > or = 40 dB SL. 2) The greater the modulation depth, the greater the suppression effect: statistical analysis showed a significant effect for 75 and 100% modulation depth. 3) The 100- and 140-Hz modulation frequencies gave the greatest suppression effect for 100 and 75% modulation depths. The suppression effect was frequency specific. The greatest decreases were observed when the carrier frequency of the contralateral AM tone was close to the frequency of the EOAE under study, i.e., 1 and 2 kHz. Acoustic cross talk and middle ear effects, which cannot be completely excluded, are discussed. However, the demonstrated frequency specificity of the EOAE suppression effect, together with observed presence of contralateral EOAE suppression in patients without stapedial reflex and the very weak intensities used (i.e., below acoustic reflex threshold), suggested that it was unlikely that the observed effects were due merely to middle ear reflexes. Our results confirm further the contralateral suppression effect on human cochlea mechanisms and show that the suppression effect can be influenced by amplitude modulations of the suppressor, characteristic of sounds in the environment.
Maison
S
S
Université Claude Bernard Lyon 1, Centre National de la Recherche Scientifique Upresa 5020, Hôpital Edouard Herriot, France.
Micheyl
C
C
Collet
L
L
D000161:Acoustic Stimulation; D000293:Adolescent; D000328:Adult; D001301:Audiometry, Pure-Tone; D001306:Auditory Pathways / Q000502:physiology*; D016022:Case-Control Studies; D003051:Cochlea / Q000502:physiology*; D004525:Efferent Pathways / Q000502:physiology; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D034381:Hearing Loss / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009622:Noise; D009847:Olivary Nucleus / Q000502:physiology*