Intravenous albumin prevents moderate-severe ovarian hyperstimulation in in-vitro fertilization patients: a prospective, randomized and controlled study.
OBJECTIVE
To assess the effectiveness of intravenous administration of albumin in prevention of ovarian hyperstimulation syndrome (OHSS) in patients of an in-vitro fertilization program.


METHODS
Prospective randomized study. Patients with hCG day E2 levels are 11010 pmol/l (3000 pg/ml) or more were recruited into two groups. Group A (n = 27) received 10 g 20%, 50 ml human albumin infusion before oocyte pick-up and no medication was administered in Group B (n = 28).


RESULTS
Patients were similar in terms of cycle characteristics. No moderate-severe OHSS developed in Group A whereas one severe OHSS case and four moderate OHSS cases developed in Group B. Statistical analysis revealed a significant (P < 0.05) protection in albumin treated group.


CONCLUSIONS
Human albumin proves effectiveness in prevention of moderate-severe OHSS.
Isik
A Z
AZ
Reproductive Endocrinology and IVF Unit, Dr. Zekai Tahir Burak Women's Hospital, Ankara, Turkey.
Gokmen
O
O
Zeyneloglu
H B
HB
Kara
S
S
Keles
G
G
Gulekli
B
B
D000328:Adult; D000418:Albumins / Q000008:administration & dosage / Q000627:therapeutic use*; D006063:Chorionic Gonadotropin / Q000008:administration & dosage; D004958:Estradiol / Q000097:blood; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007262:Infusions, Intravenous; D016471:Ovarian Hyperstimulation Syndrome / Q000517:prevention & control*; D011247:Pregnancy; D011446:Prospective Studies
D000418:Albumins; D006063:Chorionic Gonadotropin; D004958:Estradiol