title: Force, development, and neoplasia: development from another perspective as illustrated through a study of in vitro plant development from neoplasm.
abstract: Differentiation from the neoplastic state can be a dynamic adaptation to the localized stress of increasing cohesive forces in tissue. Repulsive forces, occurring within and between cells, are seen as leading to de-differentiation into the neoplastic state or neoplasm. During early development, especially where and when mitosis occurs frequently, cohesive and repulsive forces may necessarily coexist in oscillating degrees. Correspondingly, cohesive-force and repulsive-force generating metabolites may co-exist in oscillating concentrations. Cancer or neoplasia occurs, according A. Szent-Gyorgyi, when cohesiveness breaks down locally, probably thru the conversion of methylglyoxal into lactic acid. Cancer may also occur due to the accumulation of such putatively, repulsion-generating factors as lactic acid. Plant tumors in vitro respond adaptively to cohesion-generating chemicals, such as ascorbic acid and methylglyoxal, by generating buds, embryos, and plantlets.
authors.forename: M M
authors.initials: MM
authors.lastname: Lieber
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D001205:Ascorbic Acid / Q000378:metabolism / Q000494:pharmacology; D005075:Biological Evolution; D003470:Culture Media; D046508:Culture Techniques; D005314:Embryonic and Fetal Development; D007887:Fabaceae / Q000187:drug effects / Q000254:growth & development; D006801:Humans; D019344:Lactic Acid / Q000378:metabolism; D008322:Mammals; D051379:Mice; D016296:Mutagenesis; D009369:Neoplasms / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D063245:Plant Development; D010941:Plant Tumors / Q000209:etiology; D010944:Plants / Q000187:drug effects; D010946:Plants, Medicinal; D010947:Plants, Toxic; D011765:Pyruvaldehyde / Q000378:metabolism / Q000494:pharmacology; D013696:Temperature; D013997:Time Factors; D014026:Nicotiana / Q000187:drug effects / Q000254:growth & development
chemical_list: D003470:Culture Media; D019344:Lactic Acid; D011765:Pyruvaldehyde; D001205:Ascorbic Acid