title: Yeast protein serine/threonine phosphatases: multiple roles and diverse regulation.
abstract: Since the isolation of the first yeast protein phosphatase genes in 1989, much progress has been made in understanding this important group of proteins. Yeast contain genes encoding all the major types of protein phosphatase found in higher eukaryotes and the ability to use genetic approaches will complement the wealth of biochemical information available from other systems. This review will summarize recent progress in understanding the structure, function and regulation of the PPP family of protein serine-threonine phosphatases, concentrating on the budding yeast Saccharomyces cerevisiae.
authors.affiliation: Department of Biochemistry, University of Dundee, UK.
authors.forename: M J
authors.initials: MJ
authors.lastname: Stark
mesh_terms: D005656:Fungal Proteins / Q000502:physiology*; D016681:Genome, Fungal; D010749:Phosphoprotein Phosphatases / Q000502:physiology*; D054648:Protein Phosphatase 2; D017027:Protein Tyrosine Phosphatases / Q000502:physiology*; D012441:Saccharomyces cerevisiae / Q000166:cytology / Q000201:enzymology* / Q000235:genetics; D029701:Saccharomyces cerevisiae Proteins; D012694:Serine / Q000378:metabolism*
chemical_list: D005656:Fungal Proteins; D029701:Saccharomyces cerevisiae Proteins; D012694:Serine; D010749:Phosphoprotein Phosphatases; D054648:Protein Phosphatase 2; C104343:SIT4 protein, S cerevisiae; D017027:Protein Tyrosine Phosphatases