Platelet sulfotransferase in different psychiatric disorders.
The aim of our study was to measure and compare platelet phenolsulfotransferase (PST) activity in patients affected by different psychiatric disorders and in healthy volunteers. The results showed that the activity of both of the two forms of PST was significantly higher in 30 patients with obsessive-compulsive disorder and in 25 manic patients than in 20 healthy volunteers. On the contrary, normal values were found in 11 dysthymic patients, 12 bipolar depressives, and 14 patients with panic disorder, whereas lower values were found in 12 unipolar depressives and 30 patients with migraine. It would therefore seem that different neuropsychiatric disorders are associated with different levels of PST activity.
Marazziti
D
D
Institute of Psychiatry, University of Pisa, Italy. dmarazzi@psico.med.unipi.it
Palego
L
L
Dell'Osso
L
L
Batistini
A
A
Cassano
G B
GB
Akiskal
H S
HS
D000328:Adult; D001714:Bipolar Disorder / Q000175:diagnosis / Q000201:enzymology / Q000523:psychology; D001792:Blood Platelets / Q000201:enzymology*; D003866:Depressive Disorder / Q000175:diagnosis / Q000201:enzymology / Q000523:psychology; D019263:Dysthymic Disorder / Q000175:diagnosis / Q000201:enzymology / Q000523:psychology; D005260:Female; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000175:diagnosis / Q000201:enzymology* / Q000523:psychology; D008881:Migraine Disorders / Q000175:diagnosis / Q000201:enzymology / Q000523:psychology; D009771:Obsessive-Compulsive Disorder / Q000175:diagnosis / Q000201:enzymology / Q000523:psychology; D016584:Panic Disorder / Q000175:diagnosis / Q000201:enzymology / Q000523:psychology; D012016:Reference Values; D015238:Sulfotransferases / Q000097:blood*
D015238:Sulfotransferases; C044251:steroid sulfotransferase