T-cell receptors: is the repertoire inherently MHC-specific?
A debate over whether the observed specificity of the naive T-cell receptor repertoire for major histocompatibility complex molecules arises before or after selection within the thymus has apparently been settled in favour of the former by a series of new experiments.
Janeway
C A
CA
Section of Immunobiology, Yale University School of Medicine and Howard Hughes Medical Institute, New Haven, Connecticut, 06520-8011, USA.
Chervonsky
A V
AV
Sant'Angelo
D
D
D000818:Animals; D005805:Genes, MHC Class I; D005802:Genes, MHC Class II; D007108:Immune Tolerance; D008285:Major Histocompatibility Complex; D051379:Mice; D011948:Receptors, Antigen, T-Cell / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*; D013950:Thymus Gland / Q000276:immunology
D011948:Receptors, Antigen, T-Cell