Coexistence of tetrasomy 8 and trisomy 8 in a case with myeloid metaplasia with myelofibrosis.
We present a case of myeloid metaplasia with myelofibrosis (MM/MF), with tetrasomy 8 as the sole cytogenetic abnormality detected by conventional cytogenetic studies. Tetrasomy 8 was also detected by in situ interphase studies and confirmed by chromosome painting in metaphase. To our knowledge, this is the first case of MM/MF with tetrasomy 8. Noteworthy is the association with neurofibromatosis.
Solé
F
F
Laboratori de Citologia Hematologica, Hospital Central l'Aliança, Barcelona, Spain.
de Pablos
J M
JM
Woessner
S
S
Pérez
M M
MM
Jurado
M
M
Espinet
B
B
Grao
P
P
Moratalla
A
A
Esquivias
J
J
D000328:Adult; D002898:Chromosomes, Human, Pair 8; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D017253:Neurofibromatoses / Q000150:complications; D011123:Polyploidy; D055728:Primary Myelofibrosis / Q000150:complications* / Q000235:genetics* / Q000473:pathology; D014314:Trisomy