title: Intestinal pseudo-obstruction as an initial presentation of systemic sclerosis in two children.
abstract: Two children are reported in whom intestinal pseudo-obstruction was the initial manifestation of systemic sclerosis. Gastrointestinal symptoms and skin changes resolved or improved in both children following treatment with prednisone and penicillamine (case 1) or methotrexate (case 2), although radiological changes of the gastrointestinal tract persisted at 3 and 2 yr of follow-up, respectively.
authors.affiliation: Department of Pediatrics, University of British, Columbia Vancouver, Canada.
authors.forename: O
authors.initials: O
authors.lastname: Ortiz-Alvarez
authors.forename: D
authors.initials: D
authors.lastname: Cabral
authors.forename: J S
authors.initials: JS
authors.lastname: Prendiville
authors.forename: D
authors.initials: D
authors.lastname: Stringer
authors.forename: R E
authors.initials: RE
authors.lastname: Petty
authors.forename: P N
authors.initials: PN
authors.lastname: Malleson
mesh_terms: D000293:Adolescent; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D018501:Antirheumatic Agents / Q000627:therapeutic use; D002675:Child, Preschool; D003879:Dermatologic Agents / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007415:Intestinal Obstruction / Q000175:diagnosis*; D007421:Intestine, Small / Q000000981:diagnostic imaging / Q000473:pathology; D008727:Methotrexate / Q000627:therapeutic use; D010396:Penicillamine / Q000627:therapeutic use; D011241:Prednisone / Q000627:therapeutic use; D011859:Radiography; D012595:Scleroderma, Systemic / Q000175:diagnosis*; D012867:Skin / Q000473:pathology; D013270:Stomach / Q000000981:diagnostic imaging / Q000473:pathology
chemical_list: D000893:Anti-Inflammatory Agents; D018501:Antirheumatic Agents; D003879:Dermatologic Agents; D010396:Penicillamine; D011241:Prednisone; D008727:Methotrexate