IgG subclasses of human autoantibodies.
IgG comprises of four subclasses which differ from each other with respect to their biological properties. Fc gamma receptor shedding as well as a variety of T cell cytokines are influential in the distribution of these subclasses, but the route the antigen is introduced into the body is also important. With regard to nonorgan-specific autoimmune conditions, such as rheumatoid arthritis and systemic lupus erythematosus, IgG1 and IgG3 autoantibodies predominate, whereas IgG4 antibodies are regularly encountered in organ-specific autoimmune diseases. This suggests that the target organ may be continuously stimulating the immune system.
Maran
R
R
Department of Medicine 'B', Chaim Sheba Medical Center, Tel-Hashomer, Israel.
Dueymes
M
M
Le Corre
R
R
Renaudineau
Y
Y
Shoenfeld
Y
Y
Youinou
P
P
D001323:Autoantibodies / Q000145:classification* / Q000502:physiology; D001327:Autoimmune Diseases / Q000276:immunology; D002462:Cell Membrane / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000145:classification* / Q000502:physiology; D007239:Infections / Q000276:immunology
D001323:Autoantibodies; D007074:Immunoglobulin G