title: Further evidence for preaxial hallucal polydactyly as a marker of diabetic embryopathy.
abstract: Maternal diabetes has an established aetiological link with developmental abnormalities, and the prevalence of major congenital malformations in the offspring of affected women is approximately 4-8%, compared to the general population risk of about 3%. Hallucal polydactyly, particularly with an unusual proximal placement of the extra digit, has been reported as a distinctive anomaly in diabetic embryopathy. We report on a child of a diabetic mother with this unusual form of hallucal polydactyly, together with other skeletal anomalies, confirming that this malformation is a useful clinical marker for the diagnosis of diabetic embryopathy.
authors.affiliation: Genetic Services of Western Australia, Princess Margaret Hospital for Children, Perth, Western Australia.
authors.forename: J
authors.initials: J
authors.lastname: Slee
authors.forename: J
authors.initials: J
authors.lastname: Goldblatt
mesh_terms: D000015:Abnormalities, Multiple; D002675:Child, Preschool; D005260:Female; D005320:Fetal Macrosomia; D006214:Hallux; D006801:Humans; D007866:Leg / Q000002:abnormalities; D017689:Polydactyly; D011247:Pregnancy; D011254:Pregnancy in Diabetics