Neuritin: a gene induced by neural activity and neurotrophins that promotes neuritogenesis.
Neural activity and neurotrophins induce synaptic remodeling in part by altering gene expression. A cDNA encoding a glycosylphoshatidylinositol-anchored protein was identified by screening for hippocampal genes that are induced by neural activity. This molecule, named neuritin, is expressed in postmitotic-differentiating neurons of the developing nervous system and neuronal structures associated with plasticity in the adult. Neuritin message is induced by neuronal activity and by the activity-regulated neurotrophins BDNF and NT-3. Purified recombinant neuritin promotes neurite outgrowth and arborization in primary embryonic hippocampal and cortical cultures. These data implicate neuritin as a downstream effector of activity-induced neurite outgrowth.
Naeve
G S
GS
Department of Molecular Biology, Amgen Inc., Thousand Oaks, CA 91320, USA.
Ramakrishnan
M
M
Kramer
R
R
Hevroni
D
D
Citri
Y
Y
Theill
L E
LE
D000595:Amino Acid Sequence; D000818:Animals; D000906:Antibodies; D001483:Base Sequence; D001921:Brain / Q000378:metabolism*; D016466:CHO Cells; D002540:Cerebral Cortex / Q000378:metabolism; D006224:Cricetinae; D018076:DNA, Complementary; D004622:Embryo, Mammalian; D058851:GPI-Linked Proteins; D017261:Glycosylphosphatidylinositols / Q000378:metabolism; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D017403:In Situ Hybridization; D008969:Molecular Sequence Data; D009414:Nerve Growth Factors / Q000494:pharmacology*; D016501:Neurites / Q000187:drug effects / Q000502:physiology*; D009474:Neurons / Q000187:drug effects / Q000378:metabolism*; D009479:Neuropeptides / Q000096:biosynthesis* / Q000302:isolation & purification / Q000494:pharmacology*; D010446:Peptide Fragments / Q000737:chemistry / Q000276:immunology; D012333:RNA, Messenger / Q000096:biosynthesis; D051381:Rats; D011994:Recombinant Proteins / Q000096:biosynthesis / Q000494:pharmacology; D014158:Transcription, Genetic; D014162:Transfection
D000906:Antibodies; D018076:DNA, Complementary; D058851:GPI-Linked Proteins; D017261:Glycosylphosphatidylinositols; C484539:NRN1 protein, human; D009414:Nerve Growth Factors; D009479:Neuropeptides; C105161:Nrn1 protein, rat; D010446:Peptide Fragments; D012333:RNA, Messenger; D011994:Recombinant Proteins