S 15261, a novel agent for the treatment of insulin resistance. Studies on Psammomys obesus. Effect on pancreatic islets of insulin resistant animals.
A histological study has been conducted on pancreata from insulin resistant sand rats treated with S15261. As previously shown, standard laboratory chow induced dietary hyperinsulinaemia, insulin resistance and hyperlipaemia in sand rats (Psammomys obesus). Degranulation, vacuolization and even necrosis of beta-cells were observed in these animals. These changes were often accompanied by fibrosis and lymphocytic infiltration. Insulin and amylin immuno-reactivity of beta-cells was markedly decreased whilst glucagon secreting cells were localized now in the centre of the islets. Chronic treatment with S15261, a compound able to restore insulin sensitivity in insulin resistant animals, promoted the regranulation of the beta-cells and maintained the usual cytoarchitecture and integrity of the islets.
Marquié
G
G
Division Diabète et Maladies Métaboliques, Institut de Recherches Servier, Suresnes, France.
Duhault
J
J
Espinal
J
J
Petkov
P
P
Jablenska
R
R
Khallayoun
S
S
Bennani
N
N
D000818:Animals; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy; D004195:Disease Models, Animal; D005449:Fluorenes / Q000494:pharmacology*; D005849:Gerbillinae; D007333:Insulin Resistance; D007515:Islets of Langerhans / Q000187:drug effects* / Q000473:pathology
D005449:Fluorenes; C091921:S 15261