title: Cytogenetic analysis of subcutaneous angiolipoma: further evidence supporting its difference from ordinary pure lipomas: a report of the CHAMP Study Group.
abstract: Subcutaneous angiolipomas are benign soft-tissue lesions consisting of two mesenchymal elements (i.e., adipose tissue and blood vessels) and having distinct clinical features. They usually are multiple, with an obvious male predominance, and hereditary occurrence has been described. Twenty subcutaneous angiolipomas from 10 patients with typical clinical and morphologic features were reviewed. All lesions had a normal karyotype. This finding is in striking contrast with ordinary lipomas, spindle-cell and pleomorphic lipomas, lipoblastomas, and hibernomas, most of which have characteristic clonal chromosomal aberrations. The normal karyotype of subcutaneous angiolipoma as well as its distinct clinical and morphologic features suggest a different pathogenesis from pure lipomas.
authors.affiliation: Department of Pathology, University of Leuven, Belgium.
authors.forename: R
authors.initials: R
authors.lastname: Sciot
authors.forename: M
authors.initials: M
authors.lastname: Akerman
authors.forename: P
authors.initials: P
authors.lastname: Dal Cin
authors.forename: I
authors.initials: I
authors.lastname: De Wever
authors.forename: C D
authors.initials: CD
authors.lastname: Fletcher
authors.forename: N
authors.initials: N
authors.lastname: Mandahl
authors.forename: F
authors.initials: F
authors.lastname: Mertens
authors.forename: F
authors.initials: F
authors.lastname: Mitelman
authors.forename: J
authors.initials: J
authors.lastname: Rosai
authors.forename: A
authors.initials: A
authors.lastname: Rydholm
authors.forename: G
authors.initials: G
authors.lastname: Tallini
authors.forename: H
authors.initials: H
authors.lastname: Van den Berghe
authors.forename: R
authors.initials: R
authors.lastname: Vanni
authors.forename: H
authors.initials: H
authors.lastname: Willen
mesh_terms: D000328:Adult; D000368:Aged; D018206:Angiolipoma / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D002869:Chromosome Aberrations / Q000175:diagnosis / Q000473:pathology*; D025063:Chromosome Disorders; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007621:Karyotyping; D008067:Lipoma / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012878:Skin Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology