Regulation of rat neuronal nitric oxide synthase activity by chronic alcoholization.
Rat neuronal nitric oxide (NO) synthase (nNOS) activity was measured in frontal cortex, hippocampus, striatum and cerebellum using the assay of [3H]citrulline, following chronic alcoholization. The Km and Vmax values were significantly increased in the frontal cortex and in the striatum, and were not affected in the cerebellum and hippocampus.
Naassila
M
M
INSERM U295, Université de Médecine Pharmacie, Saint Etienne du Rouvray, France.
Beauge
F
F
Daoust
M
M
D000437:Alcoholism / Q000201:enzymology*; D000818:Animals; D001921:Brain / Q000201:enzymology*; D001931:Brain Mapping; D003342:Corpus Striatum / Q000201:enzymology; D004790:Enzyme Induction / Q000187:drug effects; D000431:Ethanol / Q000633:toxicity; D005625:Frontal Lobe / Q000201:enzymology; D008297:Male; D009474:Neurons / Q000201:enzymology; D019001:Nitric Oxide Synthase / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley
D000431:Ethanol; D019001:Nitric Oxide Synthase