Reassessment of PCDD/DFs and Co-PCBs toxicity in contaminated rice-bran oil responsible for the disease "Yu-Cheng".
Reassessment of dibenzo-p-dioxins and dibenzofurans (PCDD/DFs) and coplanar polychlorinated biphenyls (Co-PCBs) in toxic Yu-Cheng rice-bran oil was carried out. The contaminating source appears to be a mixture of KC-400 and KC-500. The oil contains 176 micrograms/g PCBs and 37.194 ng/g 2,3,7,8,-TCDD toxicity equivalency (TEQ). The TEQ contributions from the PCDDs (4.472 ng/g), PCDFs (19.568 ng/g), and Co-PCBs (13.154 ng/g) are 12% 53% and 35%, respectively. Complete identification and quantitation suggests that 2,3,4,7,8-PeCDF, 1,2,3,4,7,8-HxCDF, 2,3,7,8,-TCDF. 2,3,7,8-TCDD, 1,2,3,7,8-PeCDD and PCB# 77 are candidates for the primary causal agents of Yu-Cheng disease.
Soong
D K
DK
Department of Chemistry, National Tsing Hua University, Hsinchu, Taiwan, R.O.C.
Ling
Y C
YC
D001572:Benzofurans / Q000506:poisoning*; D005506:Food Contamination; D006801:Humans; D006843:Hydrocarbons, Chlorinated / Q000506:poisoning*; D012275:Oryza / Q000506:poisoning*; D010938:Plant Oils / Q000506:poisoning*; D011078:Polychlorinated Biphenyls / Q000506:poisoning; D000072317:Polychlorinated Dibenzodioxins / Q000031:analogs & derivatives* / Q000506:poisoning; D013624:Taiwan
D001572:Benzofurans; D006843:Hydrocarbons, Chlorinated; D010938:Plant Oils; D000072317:Polychlorinated Dibenzodioxins; D011078:Polychlorinated Biphenyls