Peroxidation status of erythrocytes and apolipoprotein B containing lipoproteins in hypercholesterolemic subjects.
Erythrocyte diene conjugate levels and glutathione peroxidase and superoxide dismutase activities were found unchanged in hypercholesterolemic subjects with plasma cholesterol levels of 240 mg/dl as compared to normocholesterolemics (below 200 mg/dl). However, the susceptibility of VLDL + LDL, apolipoprotein B containing lipoproteins to copper-induced peroxidation and plasma endogenous malondialdehyde levels were increased in hypercholesterolemics. These results indicate that hypercholesterolemia is associated with increased susceptibility of VLDL + LDL to lipid peroxidation.
Ozdemirler
G
G
Department of Biochemistry, Istanbul, Faculty of Medicine, University of Istanbul, Turkey.
Oztezcan
S
S
Toker
G
G
Uysal
M
M
D001055:Apolipoproteins B / Q000032:analysis*; D002784:Cholesterol / Q000097:blood; D004912:Erythrocytes / Q000378:metabolism*; D005231:Fatty Acids, Unsaturated / Q000097:blood; D005979:Glutathione Peroxidase / Q000097:blood / Q000502:physiology; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood / Q000201:enzymology / Q000378:metabolism*; D015227:Lipid Peroxidation / Q000502:physiology*; D008074:Lipoproteins / Q000737:chemistry*; D008077:Lipoproteins, LDL / Q000097:blood; D008079:Lipoproteins, VLDL / Q000097:blood; D008315:Malondialdehyde / Q000097:blood / Q000378:metabolism; D010743:Phospholipids / Q000097:blood; D013482:Superoxide Dismutase / Q000097:blood / Q000502:physiology
D001055:Apolipoproteins B; D005231:Fatty Acids, Unsaturated; D008074:Lipoproteins; D008077:Lipoproteins, LDL; D008079:Lipoproteins, VLDL; D010743:Phospholipids; D008315:Malondialdehyde; D002784:Cholesterol; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase