[Xanthine urinary calculus in a patient with Lesch-Nyhan syndrome. Apropos of a case].
The authors report a case of xanthine stones in a 12-year-old child with Lesh Nyhan syndrome treated by allopurinol at the dose of 10 mg/kg/24 hours. This type of urinary stone is unusual and its structure was confirmed by spectrophotometric analysis. This type of stone, in the context of Lesh Nyhan syndrome, suggests the presence of allopurinol treatment. Discontinuation of this treatment prevents recurrence of xanthine stones.
Volpe
P
P
Service d'Urologie, Centre Hospitalier Princesse Grace, Monaco.
Peyrottes
A
A
Lammle
M
M
Saquet
D
D
Choquenet
C
C
D000493:Allopurinol / Q000009:adverse effects*; D000963:Antimetabolites / Q000009:adverse effects*; D002648:Child; D004791:Enzyme Inhibitors / Q000032:analysis; D005500:Follow-Up Studies; D006801:Humans; D007669:Kidney Calculi / Q000737:chemistry / Q000209:etiology*; D007926:Lesch-Nyhan Syndrome / Q000150:complications / Q000188:drug therapy*; D008297:Male; D010117:Oxypurinol / Q000032:analysis; D013053:Spectrophotometry; D001744:Urinary Bladder Calculi / Q000737:chemistry / Q000209:etiology*; D019820:Xanthine; D014970:Xanthines / Q000032:analysis*
D000963:Antimetabolites; D004791:Enzyme Inhibitors; D014970:Xanthines; D019820:Xanthine; D000493:Allopurinol; D010117:Oxypurinol