Biochemical evidence for altered subchondral bone collagen metabolism in osteoarthritis of the hip.
Osteoarthritis (OA) of the hip is invariably viewed as a disease primarily affecting the articular cartilage. Data presented in this report, however, demonstrate changes in the metabolic activity of the underlying trabecular bone tissue, the processes of which may represent a significant factor in the pathogenesis of hip OA. Trabecular bone tissue from OA subjects expressed significantly more matrix metalloproteinase (MMP)-2 (gelatinase A, 72 kDa type IV collagenase) when compared to age-matched osteoporotic (OP) and normal bone tissue. Alkaline phosphatase was also significantly elevated in OA bone tissue. The combination of increased MMP-2 and alkaline phosphatase indicates heightened collagen turnover in the subchondral bone compartment of osteoarthritic hips. The data obtained from this study warrant a closer investigation into the significance of these changes in OA and emphasize the multifactorial elements of the whole joint in the whole joint in the overall disease process.
Mansell
J P
JP
Division of Molecular & Cellular Biology, University of Bristol.
Tarlton
J F
JF
Bailey
A J
AJ
D000367:Age Factors; D000469:Alkaline Phosphatase / Q000032:analysis / Q000378:metabolism; D001857:Bone Matrix / Q000737:chemistry / Q000166:cytology / Q000201:enzymology*; D003094:Collagen / Q000378:metabolism*; D017364:Collagenases / Q000032:analysis / Q000378:metabolism; D005260:Female; D005270:Femur Head / Q000737:chemistry / Q000503:physiopathology; D018093:Gelatinases / Q000032:analysis / Q000378:metabolism; D006801:Humans; D020778:Matrix Metalloproteinase 2; D020780:Matrix Metalloproteinase 9; D008666:Metalloendopeptidases / Q000032:analysis / Q000378:metabolism; D015207:Osteoarthritis, Hip / Q000378:metabolism*; D010006:Osteoblasts / Q000201:enzymology
D003094:Collagen; D000469:Alkaline Phosphatase; D017364:Collagenases; D018093:Gelatinases; D008666:Metalloendopeptidases; D020778:Matrix Metalloproteinase 2; D020780:Matrix Metalloproteinase 9