title: Antiinflammatory activity of some medicinal plant extracts form Venezuela.
abstract: Six medicinal plant extracts from Venezuela, used in traditional medicine, were investigated for their anti-inflammatory potential against adjuvant-carrageenan-induced inflammation (ACII). All doses expressed here are equivalents of dried starting plant materials (1.50 g dry plant/kg body wt.). The most interesting plant extracts were Synedrella nodiflora, and the hexane leaf extract of Bursera simaruba. In ACII, orally administered extracts (at doses 40 and 80 mg/kg, respectively), inhibited both the acute and chronic phases of this experimental model of inflammation, mainly the chronic phase. These extracts exhibited potent anti-inflammatory activity daily throughout the experiment, and were as effective as reference drugs, phenylbutazone (80 mg/kg) and indomethacin (3 mg/kg).
authors.affiliation: Department of Pharmacology, Faculty of Pharmacy, University of Complutense, Madrid, Spain.
authors.forename: M J
authors.initials: MJ
authors.lastname: Abad
authors.forename: P
authors.initials: P
authors.lastname: Bermejo
authors.forename: E
authors.initials: E
authors.lastname: Carretero
authors.forename: C
authors.initials: C
authors.lastname: Martínez-Acitores
authors.forename: B
authors.initials: B
authors.lastname: Noguera
authors.forename: A
authors.initials: A
authors.lastname: Villar
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology; D010946:Plants, Medicinal; D051381:Rats; D017207:Rats, Sprague-Dawley; D014687:Venezuela
chemical_list: D000893:Anti-Inflammatory Agents; D010936:Plant Extracts