Assignment of Alzheimer's presenilin-2 (PS-2) gene to 1q42.1 by fluorescence in situ hybridization.
Presenilin-2 (PS-2) was suggested to be localized on 1q31-42 based on linkage analysis and cDNA cloning. The final identification of PS-2 as the causal gene for early-onset familial Alzheimer's disease in Voga-German pedigrees was concluded based on the point mutation found in the candidate cDNA isolated from this familial AD. We present evidence of its physical genome mapping of PS-2 on chromosome 1q42.1 by fluorescence in situ hybridization method.
Takano
T
T
Department of Hygiene and Public Health, Teikyo University School of Medicine, Kaga, Itabashiku, Tokyo, Japan.
Sahara
N
N
Yamanouchi
Y
Y
Mori
H
H
D000544:Alzheimer Disease / Q000235:genetics*; D002874:Chromosome Mapping; D002900:Chromosomes, Human, 1-3 / Q000502:physiology*; D016650:Fluorescein-5-isothiocyanate; D008040:Genetic Linkage; D006801:Humans; D017403:In Situ Hybridization; D008565:Membrane Proteins / Q000235:genetics*; D008856:Microscopy, Fluorescence; D017354:Point Mutation; D053766:Presenilin-2
D008565:Membrane Proteins; C508861:PSEN2 protein, human; D053766:Presenilin-2; D016650:Fluorescein-5-isothiocyanate