title: Ictal cerebral perfusion related to EEG in drug resistant focal epilepsy of childhood.
abstract: OBJECTIVE
  To evaluate the EEG changes during seizures in children with drug resistant focal epilepsy who demonstrate hypoperfusion at the "seizure focus" interictally, but no perfusion change during the seizure.
  
  
  METHODS
  Ictal EEG findings of six children with focal epilepsy who demonstrated hypoperfusion on rCBF SPECT after an interictal injection of (99)Tc(m) HMPAO concordant with the seizure focus, but who did not demonstrate rCBF change after an ictal injection (group 1) were reviewed. These were contrasted with the EEG data of six children matched as closely as possible for age, type of epilepsy, and pathology who did show hyperperfusion at the seizure focus on ictal scan when compared with the interictal study (group 2).
  
  
  RESULTS
  The children in group 1 showed slowing of the EEG at the time of the (99)Tc(m) HMPAO injection relative to that seen at the onset of the seizure. Those in group 2 showed rhythmic activity, or sharp waves, or both on EEG at the time of injection. This last change was also seen consistently when the EEG data of a further 13 children who also showed ictal hyperperfusion at the seizure focus were reviewed.
  
  
  CONCLUSIONS
  Ictal rCBF does not invariably increase at the seizure focus in patients with drug resistant focal epilepsy.
authors.affiliation: Neurosciences Unit 1, Institute of Child Health, London, UK.
authors.forename: J H
authors.initials: JH
authors.lastname: Cross
authors.forename: S G
authors.initials: SG
authors.lastname: Boyd
authors.forename: I
authors.initials: I
authors.lastname: Gordon
authors.forename: A
authors.initials: A
authors.lastname: Harper
authors.forename: B G
authors.initials: BG
authors.lastname: Neville
mesh_terms: D000293:Adolescent; D000328:Adult; D001927:Brain Diseases / Q000150:complications / Q000175:diagnosis*; D001932:Brain Neoplasms / Q000150:complications / Q000175:diagnosis; D002544:Cerebral Infarction / Q000175:diagnosis; D002648:Child; D003560:Cysts / Q000150:complications / Q000175:diagnosis; D004351:Drug Resistance; D004569:Electroencephalography; D004828:Epilepsies, Partial / Q000188:drug therapy / Q000209:etiology* / Q000503:physiopathology; D006624:Hippocampus / Q000000981:diagnostic imaging; D006801:Humans; D008875:Middle Aged; D015609:Organotechnetium Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D015609:Organotechnetium Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime