Inhibition of tongue reflex in rats by tooth pulp stimulation during cerebral ventricle perfusion with (6-11) substance P analogs.
The effect of 12 C-terminal hexapeptide analogs of substance P perfused into the cerebral ventricles on the trigemino-hypoglossal reflex caused by incisor pulp stimulation in rats was investigated. A substitution of the L-isomer by D at position 6, 7, or 8 of the substance P analogs used in this study caused the most pronounced inhibition of the trigemino-hypoglossal reflex. A correlation between the degree of inhibition of the reflex and concentration of the peptide used was observed.
Zubrzycka
M
M
Department of Physiology, Institute of Physiology and Biochemistry, Medical University of Lodz, Poland.
Janecka
A
A
Koziolkiewicz
W
W
Traczyk
W Z
WZ
D000818:Animals; D002552:Cerebral Ventricles / Q000187:drug effects*; D003782:Dental Pulp / Q000502:physiology*; D004353:Drug Evaluation, Preclinical; D004558:Electric Stimulation; D007002:Hypoglossal Nerve / Q000502:physiology; D007180:Incisor; D008297:Male; D010477:Perfusion; D051381:Rats; D012018:Reflex / Q000502:physiology*; D013373:Substance P / Q000031:analogs & derivatives* / Q000494:pharmacology; D014059:Tongue / Q000294:innervation*; D014276:Trigeminal Nerve / Q000502:physiology
D013373:Substance P