title: Effects of non-pharmacological sympathetic sudomotor denervation on sweating in humans with essential palmar hyperhidrosis.
abstract: OBJECTIVE
  Quantitative sweat production and -ionic composition in Essential Hyperhidrosis (EH), and the effects of T2-T3 thoracoscopic sympathicolysis (TS) hereon, are unknown. Standardised pilocarpine iontophoresis sweat tests were performed before and after TS in order to study these issues.
  
  
  METHODS
  Pilocarpine iontophoretic sweat tests measuring maximal sweat production (mg) and sweat Na+, K+ and Cl- concentrations (mMol/L) were performed on both forearms of 10 EH patients, before and six weeks after TS, and in normal volunteers.
  
  
  RESULTS
  As compared to normals, preoperative maximal sweat production was 30% higher (199.4 +/- 68.8 (SD) vs. 150.6 +/- 45.6 mg) in EH patients; due to type II error, however, statistical significance was not reached. Na+ and Cl- concentrations were similar, and K+ concentration was slightly lower in EH patients. After TS, sweat production had decreased to equal levels as in normals (149.1 +/- 52.1 mg), whereas the Na+ (from 33.6 +/- 6.9 to 51.0 +/- 6.4 mMol/L), Cl- (from 21.5 +/- 6.6 to 37.2 +/- 7.1 mMol/L) and K+ (from 7.5 +/- 1.3 to 8.6 +/- 2.2 mMol/L) concentrations had increased.
  
  
  CONCLUSIONS
  EH patients present 30% higher maximal sweat production at their forearms. This increase may be due to an increased activity of the adrenergic component of sweat gland innervation. The post-TS increase in Na+, Cl- and K+ concentrations suggests that the adrenergic component of sweat gland innervation in itself decreases sweat ion concentrations.
authors.affiliation: Respiratory Division, Academic Hospital A.Z.-V.U.B., Free University of Brussels, Belgium.
authors.forename: M
authors.initials: M
authors.lastname: Noppen
authors.forename: C
authors.initials: C
authors.lastname: Sevens
authors.forename: W G
authors.initials: WG
authors.lastname: Vincken
mesh_terms: D000328:Adult; D004573:Electrolytes / Q000032:analysis*; D005260:Female; D005542:Forearm; D006225:Hand; D006801:Humans; D006945:Hyperhidrosis / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D010277:Parasympathomimetics; D010862:Pilocarpine; D013542:Sweat / Q000737:chemistry*; D013545:Sweat Glands / Q000378:metabolism; D013562:Sympathectomy / Q000379:methods*
chemical_list: D004573:Electrolytes; D010277:Parasympathomimetics; D010862:Pilocarpine