title: Some geiparvarin bioisosteres and homologues: synthesis and biological evaluation against human colon carcinoma cells (LoVo).
abstract: Some geiparvarin bioisosteres and homologues are described. The compounds were tested on LoVo cells (human colon carcinoma cell line). The EC50 values of the synthesized compounds ranged from 35.04 microM (compound 3) to 11.88 microM (compound 4), while the EC50 value of geiparvarin 1 was 13.30 microM.
authors.affiliation: Department of Pharmaceutical Sciences, University of Bologna, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Valenti
authors.forename: A
authors.initials: A
authors.lastname: Rampa
authors.forename: A
authors.initials: A
authors.lastname: Bisi
authors.forename: F
authors.initials: F
authors.lastname: Belluti
authors.forename: P
authors.initials: P
authors.lastname: Da Re
authors.forename: M
authors.initials: M
authors.lastname: Carrara
authors.forename: L
authors.initials: L
authors.lastname: Cima
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis* / Q000494:pharmacology*; D003110:Colonic Neoplasms / Q000188:drug therapy*; D003374:Coumarins / Q000138:chemical synthesis* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007536:Isomerism; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D003374:Coumarins; C058446:geiparvarin