title: The human cytomegalovirus major immediate-early gene.
abstract: Immediate-early genes function to regulate viral and cellular gene expression during the course of virus replication. The major immediate-early gene region of human cytomegalovirus plays a key role in affecting activation and repression of viral and cellular genes. These proteins intimately associate and/or interact with viral and cellular proteins during this process. Herein, we will discuss the current understanding of this complex gene region.
authors.affiliation: Department of Microbiology and Immunology, Eastern Virginia Medical School, Norfolk 23501, USA.
authors.forename: R M
authors.initials: RM
authors.lastname: Stenberg
mesh_terms: D000956:Antigens, Viral / Q000235:genetics*; D003587:Cytomegalovirus / Q000235:genetics*; D015967:Gene Expression Regulation, Viral; D005814:Genes, Viral; D006801:Humans; D017874:Immediate-Early Proteins / Q000235:genetics*; D008562:Membrane Glycoproteins; D015534:Trans-Activators; D014759:Viral Envelope Proteins; D014764:Viral Proteins
chemical_list: D000956:Antigens, Viral; C088645:IE1 protein, cytomegalovirus; C069186:IE2 protein, Cytomegalovirus; D017874:Immediate-Early Proteins; D008562:Membrane Glycoproteins; D015534:Trans-Activators; C077406:UL115 protein, Human herpesvirus 5; D014759:Viral Envelope Proteins; D014764:Viral Proteins; C071440:glycoprotein H, Cytomegalovirus; C499358:glycoprotein H, Human cytomegalovirus; C439068:glycoprotein O, cytomegalovirus; C044582:immediate-early proteins, cytomegalovirus