title: Intravenous infusion of diltiazem causes uricosuria with concomitant hypouricemia in rats.
abstract: The effects of the continuous intravenous infusion of diltiazem on plasma urate levels and the urinary excretion of urate were examined in urethane anesthetized oxonate-loaded rats. The intravenous infusion of diltiazem (4 or 10 mu g/rat/min) caused a gradual decrease in blood pressure, a gradual increase in renal blood flow and a transient increase in glomerular filtration rate. This infusion also caused diuresis, natriuresis, uricosuria and definite hypouricemia. Our results show that diltiazem infused i.v. has uricosuric and hypouricemic effects.
authors.affiliation: Department of Clinical Pharmacology, School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Sugino
authors.forename: H
authors.initials: H
authors.lastname: Shimada
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002121:Calcium Channel Blockers / Q000008:administration & dosage / Q000494:pharmacology*; D004110:Diltiazem / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D007262:Infusions, Intravenous; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012079:Renal Circulation / Q000187:drug effects; D012964:Sodium / Q000652:urine; D014527:Uric Acid / Q000097:blood* / Q000652:urine*; D014528:Uricosuric Agents / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D002121:Calcium Channel Blockers; D014528:Uricosuric Agents; D014527:Uric Acid; D012964:Sodium; D004110:Diltiazem