title: Use of topical NSAIDs in patients receiving systemic NSAID treatment: a pharmacy-based study in Germany.
abstract: Topical non-steroidal anti-inflammatory drugs NSAID account for two-thirds of the most frequently prescribed NSAIDs in Germany. Nevertheless, the extent of use and the benefit of local NSAIDs are viewed critically. We described the use of topical NSAIDs in people with systemic NSAID therapy. The study population consisted of 526 people with an average age of 57 years; two-thirds of the patients were women. We observed that the elderly (60 years and older) and patients with osteo- and/or rheumatoid arthritis had an increased likelihood of being treated with both topical and systemic NSAIDs. We suggest that the frequent use of topical NSAIDs in these patients is based on their supportive therapeutic effect rather than on their efficacy. Further research is needed in order to investigate the potential beneficial effects of topical NSAIDs in NSAID therapy.
authors.affiliation: Medicine & Clinical Development Department, Ciba-Geigy Ltd., Basel, Switzerland.
authors.forename: R
authors.initials: R
authors.lastname: Sift Carter
authors.forename: D
authors.initials: D
authors.lastname: Ebner
authors.forename: D
authors.initials: D
authors.lastname: Brenner
authors.forename: R
authors.initials: R
authors.lastname: Bruppacher
mesh_terms: D000287:Administration, Topical; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy; D004363:Drug Utilization; D005260:Female; D005858:Germany; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D010003:Osteoarthritis / Q000188:drug therapy; D017891:Pharmacoepidemiology
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal