Reduction of telencephalin immunoreactivity in the brain of patients with Alzheimer's disease.
Telencephalin (TLN) is a cell adhesion molecule expressed in the telencephalon of the mammalian central nervous system. We have investigated immunohistochemically the expression of TLN in human brain tissue from control subjects and patients with Alzheimer's disease (AD). In control brain, neuropil of the gray matter was stained diffusely with the anti-TLN antibody. TLN immunoreactivity was markedly decreased in the brain of AD patients, particularly in the hippocampal formation.
Hino
H
H
Department of Psychiatry, Yokohama City University, School of Medine, Yokohama, Japan.
Mori
K
K
Yoshihara
Y
Y
Iseki
E
E
Akiyama
H
H
Nishimura
T
T
Ikeda
K
K
Kosaka
K
K
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000378:metabolism*; D001921:Brain / Q000378:metabolism*; D002102:Cadaver; D015815:Cell Adhesion Molecules; D005260:Female; D006624:Hippocampus / Q000378:metabolism; D006801:Humans; D015151:Immunoblotting; D007150:Immunohistochemistry; D008297:Male; D008562:Membrane Glycoproteins / Q000378:metabolism*; D008875:Middle Aged; D009415:Nerve Net / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D010487:Periaqueductal Gray / Q000378:metabolism; D012016:Reference Values; D014018:Tissue Distribution
D015815:Cell Adhesion Molecules; C086747:ICAM5 protein, human; D008562:Membrane Glycoproteins; D009419:Nerve Tissue Proteins