title: Cerebellar atrophy after acute phenytoin intoxication.
abstract: There is some evidence that long-term phenytoin (PHT) use may occasionally give rise to irreversible cerebellar atrophy, but it is unclear whether such changes can occur after acute PHT intoxication. We describe a 38-year-old patient with accidental acute PHT overdose who developed severe cerebellar atrophy. This case provides evidence that acute PHT intoxication can, on rare occasions, result in irreversible cerebellar degeneration.
authors.affiliation: Department of Neuroepidemiology, Bombay Hospital, India.
authors.forename: T
authors.initials: T
authors.lastname: Kuruvilla
authors.forename: N E
authors.initials: NE
authors.lastname: Bharucha
mesh_terms: D000208:Acute Disease; D000328:Adult; D001284:Atrophy; D002526:Cerebellar Diseases / Q000139:chemically induced* / Q000473:pathology*; D002531:Cerebellum / Q000473:pathology*; D062787:Drug Overdose; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D010672:Phenytoin / Q000506:poisoning*
chemical_list: D010672:Phenytoin