title: Infantile-onset multisystem inflammatory disease: a differential diagnosis of systemic juvenile rheumatoid arthritis.
abstract: We describe four unrelated children with neonatal maculopapular rash, fever, arthritis, hepatosplenomegaly, lymphadenopathy, eye involvement, and neurologic symptoms. Radiographs of the joints were surprisingly similar, showing an abnormal epiphyseal and metaphyseal appearance. These clinical and radiologic findings allowed us to include these children in a very peculiar syndrome described as infantile-onset multisystemic inflammatory disease. A chondrosarcoma developed in one of our patients.
authors.affiliation: Pediatric Rheumatology Section, Hospital Italiano, Buenos Aires, Argentina.
authors.forename: C L
authors.initials: CL
authors.lastname: De Cunto
authors.forename: D I
authors.initials: DI
authors.lastname: Liberatore
authors.forename: J L
authors.initials: JL
authors.lastname: San Román
authors.forename: J C
authors.initials: JC
authors.lastname: Goldberg
authors.forename: A A
authors.initials: AA
authors.lastname: Morandi
authors.forename: G
authors.initials: G
authors.lastname: Feldman
mesh_terms: D000293:Adolescent; D001171:Arthritis, Juvenile / Q000175:diagnosis*; D002493:Central Nervous System Diseases / Q000150:complications; D002648:Child; D002675:Child, Preschool; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007249:Inflammation; D007592:Joint Diseases / Q000150:complications / Q000175:diagnosis*; D012871:Skin Diseases / Q000150:complications