title: Angioimmunoblastic lymphadenopathy-like T-cell lymphoma. A case report and immunologic study.
abstract: BACKGROUND
  Angioimmunoblastic lymphadenopathy (AILD) is rare in the head and neck and its definition remains controversial.
  
  
  METHODS
  A case of AILD with an ulcer of the lateral pharyngeal wall was studied for viral infection, immunohistologic findings and T-cell receptor (TCR) V beta rearrangement.
  
  
  RESULTS
  We observed elevation of antibodies against herpes simplex virus and herpes zoster virus as well as Epstein-Barr virus considered closely associated with AILD. The affected neck lymph node showed a preponderance of T-cells, predominantly CD4+ over CD8+ T-cells and all V beta gene families were expressed in the T-cells without enhancement of any particular TCR gene usage.
  
  
  CONCLUSIONS
  Viral infection may occur easily in patients with AILD, possibly owing to immunodeficiency. Assessment of TCR V beta gene usage indicated T-cells to non-specifically become lymphomatous in AILD-like T-cell lymphoma.
authors.affiliation: Department of Otolaryngology, Kumamoto University, School of Medicine, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Kanzaki
authors.forename: M
authors.initials: M
authors.lastname: Eura
authors.forename: K
authors.initials: K
authors.lastname: Chikamatsu
authors.forename: M
authors.initials: M
authors.lastname: Yoshida
authors.forename: K
authors.initials: K
authors.lastname: Masuyama
authors.forename: H
authors.initials: H
authors.lastname: Nishimura
authors.forename: T
authors.initials: T
authors.lastname: Ishikawa
mesh_terms: D000368:Aged; D000956:Antigens, Viral / Q000097:blood; D015333:Gene Rearrangement, beta-Chain T-Cell Antigen Receptor / Q000235:genetics; D006566:Herpesviridae Infections / Q000235:genetics / Q000473:pathology*; D018259:Herpesvirus 1, Human / Q000235:genetics / Q000276:immunology; D014645:Herpesvirus 3, Human / Q000235:genetics / Q000276:immunology; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000276:immunology; D006801:Humans; D007119:Immunoblastic Lymphadenopathy / Q000235:genetics / Q000276:immunology / Q000473:pathology*; D016130:Immunophenotyping; D008198:Lymph Nodes / Q000276:immunology / Q000473:pathology; D016399:Lymphoma, T-Cell / Q000235:genetics / Q000276:immunology / Q000473:pathology*; D008297:Male; D010610:Pharyngeal Neoplasms / Q000235:genetics / Q000473:pathology*; D016133:Polymerase Chain Reaction / Q000379:methods; D014412:Tumor Virus Infections / Q000235:genetics / Q000473:pathology*
chemical_list: D000956:Antigens, Viral