title: Behavioural problems in dementia and biochemistry: clinical aspects.
abstract: Behavioural and psychiatric problems in dementia are clinically important; they are also theoretically interesting. Neurochemical factors are likely to play a causal role in some of these problems. Two approaches to investigating the biochemical basis of behavioural problems are outlined: the correlation of prospectively collected behavioural data with postmortem neurochemical measures; and the detailed analysis of behaviour allowing investigation of underlying mechanisms. These approaches are illustrated with empirical data. David Bowen's neurochemical approach to dementia provided stimulus to this work.
authors.affiliation: Department of Psychiatry, University of Oxford.
authors.forename: T
authors.initials: T
authors.lastname: Hope
authors.forename: J
authors.initials: J
authors.lastname: Keene
mesh_terms: D000818:Animals; D003704:Dementia / Q000378:metabolism* / Q000523:psychology*; D006801:Humans; D006963:Hyperphagia / Q000209:etiology / Q000503:physiopathology; D001523:Mental Disorders / Q000209:etiology* / Q000378:metabolism*