title: Molecular cloning and characterization of a new receptor for galanin.
abstract: Galanin (GAL) is a widely distributed neuropeptide with diverse biological effects including modulation of hormone release, antinociception and modification of feeding behavior. Its effects are mediated through G-protein-coupled receptors (GPCR) for which only a single type has been cloned, GAL receptor 1 (GALR1). We describe the cloning of a second galanin receptor type, GALR2, from rat hypothalamus. The GALR2 amino acid sequence is 38% identical to GALR1 and is pharmacologically similar to GALR1 when expressed in COS-7 cells. GALR2 is encoded by a single gene containing at least one intron and expressed in a diverse range of tissues.
authors.affiliation: Department of Biochemistry and Physiology, Merck Research Laboratories, Rahway, NJ 07065, USA. howarda@merck.com
authors.forename: A D
authors.initials: AD
authors.lastname: Howard
authors.forename: C
authors.initials: C
authors.lastname: Tan
authors.forename: L L
authors.initials: LL
authors.lastname: Shiao
authors.forename: O C
authors.initials: OC
authors.lastname: Palyha
authors.forename: K K
authors.initials: KK
authors.lastname: McKee
authors.forename: D H
authors.initials: DH
authors.lastname: Weinberg
authors.forename: S D
authors.initials: SD
authors.lastname: Feighner
authors.forename: M A
authors.initials: MA
authors.lastname: Cascieri
authors.forename: R G
authors.initials: RG
authors.lastname: Smith
authors.forename: L H
authors.initials: LH
authors.lastname: Van Der Ploeg
authors.forename: K A
authors.initials: KA
authors.lastname: Sullivan
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D001667:Binding, Competitive; D003001:Cloning, Molecular; D015870:Gene Expression; D008969:Molecular Sequence Data; D005810:Multigene Family; D051381:Rats; D044088:Receptors, Galanin; D011964:Receptors, Gastrointestinal Hormone / Q000187:drug effects / Q000235:genetics*; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D014018:Tissue Distribution
chemical_list: D044088:Receptors, Galanin; D011964:Receptors, Gastrointestinal Hormone