Expression of herpes simplex associated antigens in ocular tissues following induced herpetic anterior uveitis.
Timing and distribution of the expression of herpes simplex virus, type 1, associated antigen (HSV-1 AA) positive cells were studied immunohistochemically, following unilateral inoculation of HSV-1 into the anterior chamber of BALB/c mice. Inflammatory cells appeared in the corneal limbus, the anterior chamber angle, and Schlemm's canal of the inoculated eyes within 24 hours. HSV-AA positive cells developed in this period in the non-pigmented epithelium (which corresponds to the human pigmented epithelium) of the iris and the corneal endothelium; they also appeared in the ciliary body by the day 3 and remained positive until day 7. Apparent involvement of the posterior segment of the eye was seen in only 2 of the 9 inoculated eyes on day 3. However, once invasion of the posterior segment has occurred, there appears to be a stronger reaction in the retinal non-pigmented epithelial (RnPE) layer, which corresponds to the human retinal pigmented epithelium, than in the sensory retina.
Shirane
M
M
Department of Ophthalmology, Hiroshima University School of Medicine, Japan.
D000818:Animals; D000867:Anterior Chamber / Q000821:virology; D000956:Antigens, Viral / Q000378:metabolism*; D002924:Ciliary Body / Q000473:pathology / Q000821:virology; D004195:Disease Models, Animal; D015828:Eye Infections, Viral / Q000209:etiology / Q000378:metabolism* / Q000473:pathology; D005500:Follow-Up Studies; D006561:Herpes Simplex / Q000378:metabolism* / Q000473:pathology / Q000821:virology; D018259:Herpesvirus 1, Human / Q000502:physiology*; D006801:Humans; D007150:Immunohistochemistry; D016850:Limbus Corneae / Q000473:pathology / Q000821:virology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D012160:Retina / Q000473:pathology / Q000821:virology; D014606:Uveitis, Anterior / Q000378:metabolism* / Q000473:pathology / Q000821:virology
D000956:Antigens, Viral