Detection of microalbuminuria in diabetic patients by urinary dipstick.
The present study was undertaken to determine the usefulness of a new, sensitive urinary dipstick, Micral-Test II (Boehringer-Mannheim, Mannheim, Germany) for the detection of microalbuminuria (urinary albumin concentration: 20-200 mg/l) in diabetic patients. four hundred and eleven consecutive outpatients with diabetes were screened for microalbuminuria. The diagnostic accuracy of Micral-Test II for the detection of urinary albumin excretion > 20 mg/l was assessed by comparing the urinary albumin concentration determined by Micral-Test II with radioimmunoassay (RIA). In comparison with radioimmunoassay, Micral-Test II had an overall sensitivity of 93%, specificity of 93% and positive predictive value of 89%. False negative results were found in 7% and false positives were obtained in 7% of specimens. These findings suggest that Micral-Test II may be a useful method for the screening of microalbuminuria. However, it should not be regarded as a diagnostic test and a positive result should be followed by measuring AER by a laboratory based method.
Gilbert
R E
RE
Endocrinology Unit, Austin and Repatriation Medical Center, Heidelberg, Victoria, Australia.
Akdeniz
A
A
Jerums
G
G
D000419:Albuminuria / Q000150:complications / Q000175:diagnosis* / Q000652:urine; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000652:urine*; D005188:False Negative Reactions; D005189:False Positive Reactions; D006801:Humans; D011237:Predictive Value of Tests; D011863:Radioimmunoassay / Q000592:standards; D011933:Reagent Kits, Diagnostic / Q000592:standards*
D011933:Reagent Kits, Diagnostic