Brain attack. Acute therapeutic interventions. Free radical scavengers and antioxidants.
Evidence suggesting a role of oxygen radical-induced lipid peroxidation in global and focal ischemic brain damage is reviewed, and the potential for treatment of these conditions with antioxidant compounds is highlighted. This article also presents a basis for appreciating the pharmacologic mechanisms by which oxygen radical damage can be inhibited.
Hall
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CNS Diseases Research, Pharmacia & Upjohn, Incorporated, Kalamazoo, Michigan 49001, USA.
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology* / Q000627:therapeutic use; D002545:Brain Ischemia / Q000188:drug therapy* / Q000503:physiopathology*; D004195:Disease Models, Animal; D018450:Disease Progression; D016166:Free Radical Scavengers / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D017665:Hydroxyl Radical / Q000009:adverse effects / Q000378:metabolism; D007501:Iron / Q000378:metabolism; D015227:Lipid Peroxidation / Q000502:physiology*; D018696:Neuroprotective Agents / Q000494:pharmacology* / Q000627:therapeutic use; D015424:Reperfusion; D013481:Superoxides / Q000009:adverse effects / Q000378:metabolism
D000975:Antioxidants; D016166:Free Radical Scavengers; D018696:Neuroprotective Agents; D013481:Superoxides; D017665:Hydroxyl Radical; D007501:Iron