title: Bullous delayed pressure urticaria; pressure testing may produce a systemic reaction.
abstract: We report a patient with bullous delayed pressure urticaria (DPU) and chronic idiopathic urticaria (CIU) in whom a systemic reaction occurred. The reaction occurred 18 h after a pressure test had been performed on the right forearm. Blood histamine levels were more elevated in the sample taken from the forearm on which the test had be applied. Skin biopsy revealed both intraepidermal and subepidermal bullae with a sparse dermal inflammatory infiltrate and direct immunofluorescence showed linear deposition of fibrinogen along the epidermodermal basement membrane. As far as we are aware this is only the third case of bullous DPU reported and the first associated with generalized urticaria and angioedema and severe broncho-obstruction. Possible pathophysiological mechanisms are discussed.
authors.affiliation: Department of Dermatology, Military Medical Academy. Belgrade, Yugoslavia.
authors.forename: B B
authors.initials: BB
authors.lastname: Mijailović
authors.forename: D M
authors.initials: DM
authors.lastname: Karadaglić
authors.forename: M P
authors.initials: MP
authors.lastname: Ninković
authors.forename: T M
authors.initials: TM
authors.lastname: Mladenović
authors.forename: R D
authors.initials: RD
authors.lastname: Zecević
authors.forename: M D
authors.initials: MD
authors.lastname: Pavlović
mesh_terms: D000328:Adult; D000982:Antipruritics / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D006635:Histamine H2 Antagonists / Q000627:therapeutic use; D006801:Humans; D007665:Ketotifen / Q000627:therapeutic use; D007958:Leukocyte Count; D008297:Male; D011312:Pressure / Q000009:adverse effects*; D011899:Ranitidine / Q000627:therapeutic use; D013997:Time Factors; D014581:Urticaria / Q000209:etiology* / Q000473:pathology
chemical_list: D000982:Antipruritics; D006635:Histamine H2 Antagonists; D011899:Ranitidine; D007665:Ketotifen