Suggestive linkages between markers on human 1p32-p22 and body fat and insulin levels in the Quebec Family Study.
A single-gene rodent mutation (diabetes) and a quantitative trait locus (dietary obese 1) mapped to the mid portion of mouse chromosome 4 have been related to obesity and/or insulin levels. Synteny relationships place their putative human homologs on 1p31 and 1p35-p31, respectively. In 137 sibships of adult brothers and sisters from the Québec Family Study, genetic linkages between seven microsatellite markers from 1p32-p22 and various obesity- and diabetes-related quantitative phenotypes were examined using single locus sibpair linkage analysis. Suggestive linkages were observed between markers D1S476 and body mass index (p = 0.05), fat mass (p = 0.02), the sum of six skinfolds (p = 0.02), the insulin area after an oral glucose tolerance test (p = 0.02), and between the neighboring marker D1S200 and body mass index (p = 0.03), and fat mass (p = 0.009). Suggestive linkages were also observed between the more telomeric markers D1S193 and body mass index (p = 0.03), and between the neighboring marker D1S197 and fasting insulin level (p = 0.05). No linkage was observed with the trunk to extremity skinfolds ratio. These linkages suggest that human homologs of the mouse diabetes or dietary obese 1 and/or other genes in this interval on chromosome 1 play a role in the regulation of body mass, body composition, and insulin levels, but not of subcutaneous fat distribution.
Chagnon
Y C
YC
Physical Activity Sciences Laboratory, Laval University, Ste-Foy, Québec, Canada.
Pérusse
L
L
Lamothe
M
M
Chagnon
M
M
Nadeau
A
A
Dionne
F T
FT
Gagnon
J
J
Chung
W K
WK
Leibel
R L
RL
Bouchard
C
C
D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D001823:Body Composition / Q000235:genetics*; D015992:Body Mass Index; D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1; D003920:Diabetes Mellitus / Q000097:blood / Q000235:genetics; D004195:Disease Models, Animal; D005192:Family Health; D005260:Female; D008040:Genetic Linkage; D006801:Humans; D007328:Insulin / Q000097:blood* / Q000235:genetics*; D007333:Insulin Resistance / Q000235:genetics; D008297:Male; D051379:Mice; D018895:Microsatellite Repeats / Q000235:genetics; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000235:genetics; D010641:Phenotype; D011792:Quebec / Q000453:epidemiology; D051381:Rats; D012689:Sequence Homology, Nucleic Acid; D012885:Skinfold Thickness
D007328:Insulin