[Experimental autoimmune labyrinthitis: evaluation of various models in guinea pigs].
Evidence of hearing loss in humans with systemic autoimmune disease has suggested the possibility of isolated forms of deafness originated by a autoimmune mechanism. Several authors reject McCabe's (1) proposed clinical description based mainly on response to treatment and have attempted to develop an animal model of autoimmune deafness. A comparative analysis was made of several experimental models of sensorineural hearing loss in guinea pigs developed in our laboratory for the study of this problem.
García-Berrocal
J R
JR
Servicio de ORL, Clínica Puerta de Hierro, Universidad Autónoma de Madrid.
Vicente
J
J
Arellano
B
B
González
F
F
Ramírez-Camacho
R
R
D000818:Animals; D015551:Autoimmunity; D004195:Disease Models, Animal; D005260:Female; D006168:Guinea Pigs; D006319:Hearing Loss, Sensorineural / Q000209:etiology; D007762:Labyrinthitis / Q000276:immunology*