Early delineation of cerebral glioma using amino acid positron tracers.
A 56-yr-old housewife with cerebral astrocytoma was reported with positron emission tomography findigns using 11C-methyl-L-methionine (11C-Met) and 18F-fluorophenylalanine (18F-Phe) tracers. 11C-Met and 18F-Phe accumulated intensely in tumor lesions, although CT scans showed only a foggy low-density area. Five years and one month after, an enhancing mass appeared on CT scans. Thus, amino acid tracers may play a important role in the early diagnosis of gliomas.
Mineura
K
K
Neurosurgical Service, Akita University Hospital, Japan. mineura@med.akita-u.ac.jp
Sasajima
T
T
Kowada
M
M
Ogawa
T
T
Hatazawa
J
J
Uemura
K
K
D001254:Astrocytoma / Q000000981:diagnostic imaging*; D001932:Brain Neoplasms / Q000000981:diagnostic imaging*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008715:Methionine / Q000031:analogs & derivatives*; D008875:Middle Aged; D014055:Tomography, Emission-Computed; D014057:Tomography, X-Ray Computed; D010135:p-Fluorophenylalanine
D010135:p-Fluorophenylalanine; D008715:Methionine; C038344:methionine methyl ester