Mouse mammary tumor virus and mammary tumorigenesis in wild mice.
The current knowledge of the distribution of the mouse mammary tumor virus (MMTV) proviral genomes and the mechanism of mammary tumorigenesis by MMTV in mice, with the main emphasis on Asian feral mice, is reviewed. The relevant earlier discoveries on the mode of MMTV transmission are summarized to provide an outline of the biology of MMTV. Finally, the viral etiology of human breast cancer will be discussed.
Imai
S
S
Nara Prefectural Institute of Public Health, Japan.
D000818:Animals; D000835:Animals, Wild / Q000235:genetics / Q000821:virology*; D001943:Breast Neoplasms / Q000235:genetics; D004273:DNA, Neoplasm / Q000235:genetics; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D006801:Humans; D008325:Mammary Neoplasms, Experimental / Q000235:genetics / Q000821:virology*; D008324:Mammary Tumor Virus, Mouse / Q000235:genetics / Q000302:isolation & purification / Q000648:ultrastructure; D051379:Mice; D012192:Retroviridae Infections / Q000209:etiology* / Q000235:genetics / Q000635:transmission; D017422:Sequence Analysis, DNA; D014412:Tumor Virus Infections / Q000209:etiology* / Q000235:genetics / Q000635:transmission
D004273:DNA, Neoplasm; D004279:DNA, Viral