Tissue ablation using an acoustic waveguide for high-intensity focused ultrasound.
High-intensity focused ultrasound (HIFU) has been shown capable of selective tissue destruction in humans, with promise as a tool for ablation of tumors, although one practical problem is reflection of sound at gas or bony interfaces within the body. We evaluated a water-filled cylindrical metal tube as a waveguide for HIFU, since such a general technique might be useful for ablation of otherwise inaccessible tumors in the body. Our studies indicate that such a waveguide is capable of propagating HIFU from a piezoelectric source, with resultant heating of tissue specimens to greater than 80 degrees C, causing focal tissue destruction.
Sommer
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FG
Department of Radiology, Stanford University Medical Center, California 94305, USA.
Sumanaweera
T S
TS
Glover
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G
D000818:Animals; D002417:Cattle; D006358:Hot Temperature; D006801:Humans; D018482:Muscle, Skeletal / Q000473:pathology; D009369:Neoplasms / Q000628:therapy*; D019047:Phantoms, Imaging; D014464:Ultrasonic Therapy / Q000295:instrumentation* / Q000379:methods; D014867:Water
D014867:Water