title: Toxicity testing of chemical mixtures: some general aspects and need of international guidelines.
abstract: The topics discussed by the Working Group on Toxicity Testing of Chemical Mixtures included the following (1) the study designs and results from two real-life exposure scenarios as additional information to the various investigations reported at the conference; (2) the need to take into consideration low-level, long-term exposure (i.e. mimicking human exposure conditions) as well as the issue of limited resources in experimental toxicology studies; (3) the importance of exploring alternative and predictive toxicology methodologies to minimize animal use and to conserve resources; (4) the realization that interactive toxicity should include the consideration of physical and biological agents in addition to chemicals. Two specific studies reported at the conference were also discussed. A number of recommendations were made concerning the planning and implementation of toxicology studies on chemical mixtures.
authors.affiliation: Virchow Clinic, Augustenburger Platz I, Berlin, Germany.
authors.forename: H
authors.initials: H
authors.lastname: Kappus
authors.forename: R S
authors.initials: RS
authors.lastname: Yang
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D017408:Guidelines as Topic; D015386:Hazardous Substances / Q000633:toxicity*; D006801:Humans; D007391:International Cooperation; D012016:Reference Values; D012107:Research Design / Q000592:standards / Q000639:trends; D018675:Toxicity Tests / Q000592:standards* / Q000639:trends
chemical_list: D015386:Hazardous Substances