Isolated intracranial metastasis of neuroblastoma 2 years after completion of therapy.
Metastatic neuroblastoma in the brain without evidence of intracranial or extracranial disease elsewhere, is a very rare event. The pattern of spread is believed to be via the hematogenous route or cerebrospinal fluid. A child with a cystic neuroblastoma mass in the right temporal lobe 23 months following completion of therapy for the initial disease is described here. Chemotherapy with the protocol 'eight drugs in 1 day' was initially effective for this patient.
Lydaki
E
E
Department of Pediatric Hematology-Oncology, University Hospital of Heraklion, Crete, Greece.
Bolonaki
I
I
Stiakaki
E
E
Dini
G
G
Kalmanti
M
M
D000310:Adrenal Gland Neoplasms / Q000188:drug therapy / Q000473:pathology*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001921:Brain / Q000473:pathology; D001932:Brain Neoplasms / Q000556:secondary*; D002675:Child, Preschool; D017809:Fatal Outcome; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008339:Mandibular Neoplasms / Q000188:drug therapy / Q000473:pathology*; D009447:Neuroblastoma / Q000556:secondary*; D013702:Temporal Lobe