title: Synthesis of new (4-alkylamino-4'-fluoro)-diphenyl sulphones with potential biological activity.
abstract: In the present work, we report the synthesis and characterization of five (4-alkylalmino-4'-fluoro)-diphenyl sulphones, four of which have not been described before. In a preliminary evaluation of their biological activity, these products showed no effect on several Gram-positive and Gram-negative bacteria and yeasts.
authors.affiliation: Instituto de Química, USP, São Paulo, SP, Brasil.
authors.forename: P T
authors.initials: PT
authors.lastname: de Sousa Júnior
authors.forename: J
authors.initials: J
authors.lastname: Miller
authors.forename: A M
authors.initials: AM
authors.lastname: Giesbrecht
mesh_terms: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D013329:Structure-Activity Relationship; D013450:Sulfones / Q000138:chemical synthesis* / Q000494:pharmacology; D015003:Yeasts / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000935:Antifungal Agents; D013450:Sulfones