title: Enhancement of attention processing by Kantroll in healthy humans: a pilot study.
abstract: This is the first report in humans of the effects of daily ingestion of a specific amino acid mixture, Kantroll, on cognitive event-related potentials (ERPs) associated with performance. Cognitive ERPs were generated by two computerized visual attention tasks, the Spatial Orientation Task (SOT) and Contingent Continuous Performance Task (CCPT), in normal young adult volunteers, where each subject acted as his own control for testing before and after 28-30 days of amino acid ingestion. A statistically significant amplitude enhancement of the P300 component of the ERPs was seen after Kantroll for both tasks, as well as improvement with respect to cognitive processing speeds. The enhancement of neurophysiologic function observed in this study on normal controls is consistent with the facilitation of recovery of individuals with RDS (i.e., substance use disorder, ADHD, carbohydrate bingeing) following the ingestion of the amino acid supplement, Kantroll, and warrants additional placebo-controlled, double-blind, studies to confirm and extend these results.
authors.affiliation: University of Texas Health Science Center, Houston 77025, USA.
authors.forename: J F
authors.initials: JF
authors.lastname: DeFrance
authors.forename: C
authors.initials: C
authors.lastname: Hymel
authors.forename: M C
authors.initials: MC
authors.lastname: Trachtenberg
authors.forename: L D
authors.initials: LD
authors.lastname: Ginsberg
authors.forename: F C
authors.initials: FC
authors.lastname: Schweitzer
authors.forename: S
authors.initials: S
authors.lastname: Estes
authors.forename: T J
authors.initials: TJ
authors.lastname: Chen
authors.forename: E R
authors.initials: ER
authors.lastname: Braverman
authors.forename: J G
authors.initials: JG
authors.lastname: Cull
authors.forename: K
authors.initials: K
authors.lastname: Blum
mesh_terms: D000328:Adult; D000596:Amino Acids / Q000008:administration & dosage / Q000494:pharmacology*; D001288:Attention / Q000187:drug effects*; D004569:Electroencephalography / Q000187:drug effects*; D018913:Event-Related Potentials, P300 / Q000187:drug effects*; D006801:Humans; D008297:Male; D008903:Minerals / Q000008:administration & dosage / Q000494:pharmacology*; D010865:Pilot Projects; D013647:Task Performance and Analysis; D014815:Vitamins / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D000596:Amino Acids; D008903:Minerals; C057940:Tropamine; D014815:Vitamins