Signal transduction: clamping down on Src activity.
Recent high-resolution structures of members of the Src family of protein-tyrosine kinases illustrate how a series of cooperative intramolecular interactions represses the catalytic activity of these kinases, but allows for their rapid activation by a variety of regulatory inputs.
Mayer
B J
BJ
Howard Hughes Medical Institute, Children's Hospital, Department of Microbiology and Molecular Genetics, Harvard Medical School, 320 Longwood Avenue, Boston, Massachusetts 02115, USA. bmayer@rascal.med.harvard.edu.
D000818:Animals; D002384:Catalysis; D006801:Humans; D008961:Models, Structural; D017433:Protein Structure, Secondary; D016392:Proto-Oncogene Proteins pp60(c-src) / Q000737:chemistry / Q000378:metabolism; D015398:Signal Transduction; D019061:src-Family Kinases / Q000737:chemistry* / Q000378:metabolism*
D016392:Proto-Oncogene Proteins pp60(c-src); D019061:src-Family Kinases