Smoking cessation increases the resistance of low-density lipoprotein to oxidation.
The effects of smoking cessation on the susceptibility to oxidation of low-density lipoprotein (LDL) was investigated in 14 men who quit smoking for 3 months. LDL was isolated and susceptibility of LDL to V-70 (4-methoxy-2,4-dimethylvalerinitrile)-mediated oxidation was assessed by measuring conjugated diene production at 234 nm, the lag phase being a measure of the resistance of LDL to oxidation. The mean duration of the lag phase became 1.9-fold longer after 3 months (P < 0.001). The result suggests that the increase in resistance of LDL to oxidation contributes to the reduction of the risk of coronary heart disease by smoking cessation.
Sasaki
A
A
Department of Preventive Medicine, Jikei University School of Medicine, Tokyo, Japan. i36274@m-unix.cc.u-tokyo.ac.jp
Kondo
K
K
Sakamoto
Y
Y
Kurata
H
H
Itakura
H
H
Ikeda
Y
Y
D000328:Adult; D006801:Humans; D008077:Lipoproteins, LDL / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D010084:Oxidation-Reduction; D016540:Smoking Cessation
D008077:Lipoproteins, LDL