title: IDPH-8261--a new nonsteroidal antiinflammatory agent.
abstract: IDPH-8261, methyl alpha-methyl-4-(3-thienyl)benzeneacetate, exhibited marked anti-inflammatory activity in acute, subacute and chronic models of inflammation. In rats, IDPH-8261 exhibited a dose related inhibition of carrageenin-induced rat paw edema and the inhibition was greater than ibuprofen, phenylbutazone, but was three times less than indomethacin. It exhibited anti-inflammatory activity in normal and adrenalectomized rats. It also exhibited the activity against various phlogistic agents. IDPH-8261 exhibited AI activity in subacute granuloma tests. In adjuvant-induced established polyarthritis. IDPH-8261 exhibited anti-arthritic effect at a very low dose (ED50 = 4 mg/kg, p.o.). Ulcerogenic liability was the lowest (UD50 = 180 mg/kg, p.o.), when compared to reference standard drugs. Low toxicity and high efficacy may make this compound a potentially useful therapeutic agent.
authors.affiliation: Department of Pharmacology, IDPL Research Center, Hyderabad, India.
authors.forename: C S
authors.initials: CS
authors.lastname: Rao
authors.forename: P P
authors.initials: PP
authors.lastname: Singh
authors.forename: A Y
authors.initials: AY
authors.lastname: Junnarkar
authors.forename: N
authors.initials: N
authors.lastname: Muralidhar
authors.forename: B S
authors.initials: BS
authors.lastname: Trivedi
authors.forename: B E
authors.initials: BE
authors.lastname: Rao
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis / Q000494:pharmacology* / Q000633:toxicity; D002351:Carrageenan / Q000494:pharmacology; D004285:Dogs; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D010648:Phenylacetates / Q000138:chemical synthesis / Q000494:pharmacology*; D051381:Rats; D014456:Ulcer / Q000188:drug therapy
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D010648:Phenylacetates; C105900:IDPH 8261; D002351:Carrageenan