Effects of fluvoxamine on food intake during rebound hyperphagia in rats.
We examined the effects of fluvoxamine on food intake during rebound hyperphagia induced by a time-restricted feeding schedule in rats. Rats were allowed access to food for only 2 h daily for 7 days, and then had free access to food for 7 consecutive days. The daily food intake of the rats was dramatically increased, by 42.5% (rebound hyperphagia), for 7 days of the free-feeding period. Intraperitoneal injection of fluvoxamine decreased food intake significantly in a dose-dependent manner for the first 3 h of feeding during 7 days. When rats were allowed access to one of the standard, carbohydrate-, fat-, or protein-rich diets in the free-feeding period following the time-restricted feeding schedule, fluvoxamine significantly decreased food intakes of standard, carbohydrate- and fat-rich diets on all days, and the protein-rich diet after the 2nd day of the free-feeding period. These results indicate that fluvoxamine, irrespective of the diet composition, suppresses rebound hyperphagia induced by a time-restricted feeding schedule, but that its effect is short-lived.
Inoue
K
K
Department of Neuropsychiatry, Osaka City University Medical School, Japan.
Kiriike
N
N
Fujisaki
Y
Y
Kurioka
M
M
Yamagami
S
S
D000818:Animals; D004195:Disease Models, Animal; D004435:Eating / Q000187:drug effects*; D005260:Female; D016666:Fluvoxamine / Q000494:pharmacology*; D006963:Hyperphagia / Q000188:drug therapy*; D051381:Rats; D017208:Rats, Wistar
D016666:Fluvoxamine