Patterns of content, contextual, and working memory impairments in schizophrenia and nonamnesic alcoholism.
This study used tests of content memory (item recognition of words and abstract designs), context memory (order recognition of verbal and nonverbal items), and working memory (recognition at a short retention interval) to examine patterns of performance in 27 schizophrenic patients, 52 chronic alcoholic patients, and 66 healthy control participants. When performance was age- and IQ-adjusted the schizophrenia group was significantly impaired in item and order recognition of verbal and nonverbal material; the alcoholic group was impaired only in order recognition for both material types. Item- and order-recognition deficits in the schizophrenia group were greatest at the shortest retention intervals, a pattern previously observed in patients with Parkinson's disease, suggesting a prominence of a working memory deficit in schizophrenia.
Sullivan
E V
EV
Veterans Affairs Palo Alto Health Care System, California, USA. edie@alois.icon.palo-alto.med.va.gov
Shear
P K
PK
Zipursky
R B
RB
Sagar
H J
HJ
Pfefferbaum
A
A
D000328:Adult; D000368:Aged; D000437:Alcoholism / Q000523:psychology*; D005260:Female; D006801:Humans; D007802:Language; D008297:Male; D008568:Memory / Q000502:physiology*; D008875:Middle Aged; D012565:Schizophrenic Psychology