Lack of vasodilatory response in skeletal muscle blood vessels of aged spontaneously hypertensive rats.
Regional hemodynamic responses to the vasodilators, hydralazine (1 mg/kg, i.v.) and verapamil (0.1 mg/kg/min, i.v.), were examined in conscious Wistar Kyoto rats (WKY) and spontaneously hypertensive rats (SHR), 15 and 50 weeks of age, using the radioactive microsphere method. The flow rates of heart and skeletal muscle in SHR were higher than those in WKY, and the flow rates of liver, kidney, intestines, and skin in SHR were lower than those in WKY. These differences between the regional blood flow in WKY and SHR were observed in both aged and young rats. The changes in organ blood flow induced by hydralazine and verapamil were similar for WKY and SHR in most organs. Both drugs increased the skeletal muscle blood flow in WKY and young SHR, but not in aged SHR, that is, the skeletal muscle blood vessels in aged SHR lost their vasodilatory response. These results suggest that, although a lack of vasodilatory responses in the skeletal muscle vasculature of aged SHR may be triggered by persistent hypertension, the vital organ vasculature maintains its normal vasodilating capacity.
Horiuchi
K
K
Department of Pharmacology, Kagawa Medical School, Japan.
He
H
H
Tomohiro
A
A
Aki
Y
Y
Kimura
S
S
Tamaki
T
T
Abe
Y
Y
D000367:Age Factors; D000818:Animals; D006439:Hemodynamics / Q000187:drug effects; D006830:Hydralazine / Q000494:pharmacology*; D006973:Hypertension / Q000503:physiopathology*; D018482:Muscle, Skeletal / Q000098:blood supply*; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D012039:Regional Blood Flow / Q000187:drug effects; D014664:Vasodilation / Q000187:drug effects*; D014665:Vasodilator Agents / Q000494:pharmacology*; D014700:Verapamil / Q000494:pharmacology*
D014665:Vasodilator Agents; D006830:Hydralazine; D014700:Verapamil