title: Lymphocyte activation in allergic reactions elicited by small-molecular-weight compounds.
abstract: The involvement of cytochrome-P450-dependent metabolism of small-molecular-weight compounds as a prerequisite for an optimal lymphocyte response to those compounds is discussed on the basis of studies with compound such as p-phenylenediamine, sulfamethoxazole, chloramphenicol and fragrances. Subsequently, data on cytochrome P450 activity and CYP gene expression in monocytes and MAC-6 cells for cytochromes P450 2E1 and 3A4 are presented.
authors.affiliation: Department of Dermatology, University Hospital, RWTH Aachen, Germany.
authors.forename: H F
authors.initials: HF
authors.lastname: Merk
authors.forename: J
authors.initials: J
authors.lastname: Baron
authors.forename: M
authors.initials: M
authors.lastname: Hertl
authors.forename: D
authors.initials: D
authors.lastname: Niederau
authors.forename: A
authors.initials: A
authors.lastname: Rübben
mesh_terms: D002701:Chloramphenicol / Q000276:immunology; D003577:Cytochrome P-450 Enzyme System / Q000502:physiology; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology*; D008213:Lymphocyte Activation; D008970:Molecular Weight; D009000:Monocytes / Q000201:enzymology; D010655:Phenylenediamines / Q000276:immunology; D013449:Sulfonamides / Q000276:immunology
chemical_list: D010655:Phenylenediamines; D013449:Sulfonamides; D002701:Chloramphenicol; D003577:Cytochrome P-450 Enzyme System; C029728:4-phenylenediamine