Amyloid precursor protein mRNAs in Alzheimer's disease.
Hybridization studies of mRNA link genetic with neurochemical and neuropathological approaches to Alzheimer's disease (AD). Here we review the distribution and abundance of amyloid precursor protein mRNAs in normal and AD-afflicted brains. The expression of apolipoprotein E and presenilin mRNAs are also discussed.
Harrison
P J
PJ
Department of Psychiatry, University of Oxford. paul.harrison@psychiatry.ox.ac.uk
Wighton-Benn
W H
WH
Heffernan
J M
JM
Sanders
M W
MW
Pearson
R C
RC
D000544:Alzheimer Disease / Q000378:metabolism*; D016564:Amyloid beta-Protein Precursor / Q000235:genetics*; D000818:Animals; D001057:Apolipoproteins E / Q000235:genetics; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics; D053764:Presenilin-1; D053766:Presenilin-2; D012333:RNA, Messenger / Q000378:metabolism*; D014018:Tissue Distribution
D016564:Amyloid beta-Protein Precursor; D001057:Apolipoproteins E; D008565:Membrane Proteins; C508853:PSEN1 protein, human; C508861:PSEN2 protein, human; D053764:Presenilin-1; D053766:Presenilin-2; D012333:RNA, Messenger