Chromatin remodeling and transcription.
Recent advances highlight two important chromatin remodeling systems involved in the transcriptional process. One system includes several members of the evolutionarily conserved SWI2/SNF2 family found in distinct multiprotein complexes with ATP-dependent nucleosome destabilizing activity; the other is the enzymatic system that governs histone acetylation and deacetylation. Identification of the catalytic subunits of these opposing histone-modifying activities reveal conserved proteins defined genetically as transcriptional regulators.
Tsukiyama
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Laboratory of Molecular Cell Biology, National Cancer Institute, National Institutes of Health, Building 37, Room 5E-26, Bethesda, Maryland, 20892-4255, USA.
Wu
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D000107:Acetylation; D000123:Acetyltransferases; D000255:Adenosine Triphosphate; D000818:Animals; D018797:Cell Cycle Proteins / Q000378:metabolism; D002843:Chromatin; D004247:DNA / Q000737:chemistry; D004265:DNA Helicases; D004268:DNA-Binding Proteins / Q000378:metabolism; D005656:Fungal Proteins / Q000378:metabolism; D051548:Histone Acetyltransferases; D006655:Histone Deacetylases / Q000378:metabolism; D006657:Histones; D006801:Humans; D009687:Nuclear Proteins / Q000378:metabolism; D009690:Nucleic Acid Conformation; D009707:Nucleosomes; D011494:Protein Kinases / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins; D035381:TATA-Binding Protein Associated Factors; D013768:Tetrahymena; D035362:Transcription Factor TFIID; D014157:Transcription Factors / Q000378:metabolism; D014158:Transcription, Genetic; D050880:p300-CBP Transcription Factors; D000099224:p300-CBP-Associated Factor
D000123:Acetyltransferases; D000255:Adenosine Triphosphate; D018797:Cell Cycle Proteins; D002843:Chromatin; D004247:DNA; D004265:DNA Helicases; D004268:DNA-Binding Proteins; D005656:Fungal Proteins; D051548:Histone Acetyltransferases; D006655:Histone Deacetylases; D006657:Histones; D009687:Nuclear Proteins; D009707:Nucleosomes; D011494:Protein Kinases; D029701:Saccharomyces cerevisiae Proteins; D035381:TATA-Binding Protein Associated Factors; D035362:Transcription Factor TFIID; D014157:Transcription Factors; D050880:p300-CBP Transcription Factors; D000099224:p300-CBP-Associated Factor; C489847:CHD1 protein, S cerevisiae; C499336:SMARCA1 protein, human; C084011:SMARCA2 protein, human; C069001:TATA-binding protein associated factor 250 kDa; C084108:SMARCA4 protein, human; C080359:CHD1 protein, human