Identification of projections from the central nucleus of the amygdala to the paraventricular nucleus of the hypothalamus which are immunoreactive for corticotrophin-releasing hormone in the rat.
Corticotrophin-releasing hormone (CRH) immunoreactivity was detected in neurons of the central nucleus of the amygdala that were retrogradely labelled by injection of a fluorescent tracer (True Blue) into the paraventricular nucleus of the hypothalamus (PVN). The double-labelled neurons were located mainly in the medial subdivision of the central nucleus and appeared to comprise less than one-fifth of the descending pathway. These results suggest that CRH may act as a neurotransmitter in the amygdalo-hypothalamic pathway.
Marcilhac
A
A
Neuroendocrinologícal Laboratory, INSERM U 297, University of Medicine, Marseille, France.
Siaud
P
P
D000679:Amygdala / Q000033:anatomy & histology / Q000166:cytology / Q000378:metabolism*; D000818:Animals; D001572:Benzofurans; D002452:Cell Count; D003346:Corticotropin-Releasing Hormone / Q000378:metabolism*; D005456:Fluorescent Dyes; D007150:Immunohistochemistry; D008297:Male; D009434:Neural Pathways / Q000033:anatomy & histology / Q000378:metabolism; D009474:Neurons / Q000378:metabolism / Q000502:physiology; D010286:Paraventricular Hypothalamic Nucleus / Q000033:anatomy & histology / Q000166:cytology / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley
D001572:Benzofurans; D005456:Fluorescent Dyes; C038675:true blue; D003346:Corticotropin-Releasing Hormone