Differential effects of lithium on platelet protein phosphorylation in bipolar patients and healthy subjects.
In the present study we have investigated the cAMP-dependent phosphorylation system in platelets of euthymic bipolar patients and healthy volunteers before and after 15 days of lithium treatment. The results showed that 15 days of lithium treatment enhanced the basal and the cAMP-stimulated 32P incorporation in the 22 and 38 kDa phosphoproteins in bipolar patients, but not in healthy subjects. Moreover, we provided further evidence of increased phosphorylation in the 22 kDa platelet phosphoprotein in untreated euthymic bipolar patients when compared with controls. Overall, these findings suggest an implication of protein phosphorylation in the biochemical action of lithium and in the pathophysiology of bipolar disorder.
Zanardi
R
R
Istituto Scientifico H. San Raffaele, Department of Neuropsychiatric Sciences, School of Medicine, University of Milan, Italy.
Racagni
G
G
Smeraldi
E
E
Perez
J
J
D000328:Adult; D018692:Antimanic Agents / Q000494:pharmacology*; D001714:Bipolar Disorder / Q000097:blood*; D001792:Blood Platelets / Q000187:drug effects* / Q000378:metabolism; D000242:Cyclic AMP / Q000494:pharmacology; D006801:Humans; D008094:Lithium / Q000494:pharmacology*; D008297:Male; D010761:Phosphorus Radioisotopes; D010766:Phosphorylation / Q000187:drug effects
D018692:Antimanic Agents; D010761:Phosphorus Radioisotopes; D008094:Lithium; D000242:Cyclic AMP