title: Rabbit haemorrhagic disease: the new scourge of Oryctolagus cuniculus.
abstract: A new, widespread and important disease of rabbits, rabbit haemorrhagic disease (RHD), is concisely reviewed and discussed. RHD is an acute, infectious condition of adult rabbits and morbidity and mortality, after a relatively short incubation period, can be very high. The disease appears typically as a necrotizing hepatitis with associated haemorrhaging, and death occurs as a result of generalized organ dysfunction. RHD is caused by a calicivirus, antigenically related to a similar virus found in brown hares but distinct from other known caliciviruses, and is spread to susceptible rabbits by a number of routes and vectors. The disease is easily identified and can be effectively controlled in commercial and domestic rabbit populations by slaughter and vaccination regimes. The occurrence of pre-existing cross-reacting antibody in a proportion of rabbits unchallenged by the disease implies the presence of non-pathogenic strains of the virus. This antibody protects against disease on subsequent exposure to RHD. Uniquely, pre-existing antibody does not occur in rabbits in Australia where, after accidental release, the virus is currently spreading rapidly.
authors.affiliation: Department of Virology, Central Veterinary Laboratory, Addlestone, Surrey, UK.
authors.forename: D
authors.initials: D
authors.lastname: Chasey
mesh_terms: D000818:Animals; D001315:Australia; D017250:Caliciviridae Infections / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*; D017929:Hemorrhagic Disease Virus, Rabbit / Q000235:genetics / Q000276:immunology / Q000472:pathogenicity; D011817:Rabbits