title: Early protection of puppies against canine parvovirus: a comparison of two vaccines.
abstract: Client-owned puppies randomly were assigned to receive one of two commercially available polyvalent vaccines. The response to the parvovirus portion of each vaccine was evaluated by determining antibody titers by hemagglutination inhibition. Significant differences were found between titers produced by the vaccines. Puppies vaccinated with one of the products had a more desirable result as demonstrated by a protective antibody titer after the first vaccination (p of 0.005), a protective antibody titer at a younger age (p of 0.02), a protective antibody titer by 12 weeks of age (p of 0.001), and a protective antibody titer by 16 weeks of age (p of 0.05). Puppies vaccinated with this product also had significantly higher titers at each sampling after vaccination.
authors.affiliation: Department of Veterinary Medicine, University of Missouri, Columbia 65211, USA.
authors.forename: D L
authors.initials: DL
authors.lastname: McCaw
authors.forename: D
authors.initials: D
authors.lastname: Tate
authors.forename: E J
authors.initials: EJ
authors.lastname: Dubovi
authors.forename: J C
authors.initials: JC
authors.lastname: Johnson
mesh_terms: D000375:Aging / Q000276:immunology; D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis / Q000276:immunology; D004283:Dog Diseases / Q000276:immunology / Q000517:prevention & control*; D004285:Dogs; D005260:Female; D006385:Hemagglutination Inhibition Tests / Q000662:veterinary; D008297:Male; D010322:Parvoviridae Infections / Q000276:immunology / Q000517:prevention & control / Q000662:veterinary*; D017993:Parvovirus, Canine / Q000276:immunology*; D012044:Regression Analysis; D014611:Vaccination / Q000379:methods / Q000662:veterinary; D014765:Viral Vaccines / Q000276:immunology / Q000592:standards
chemical_list: D000914:Antibodies, Viral; D014765:Viral Vaccines