Decreased anterior cingulate gyrus metabolic rate in schizophrenia.
OBJECTIVE
This study examined glucose metabolism in the anterior and posterior cingulate cortex in schizophrenia.


METHODS
Fifty unmedicated male schizophrenic patients and 24 normal men were studied with positron emission tomography.


RESULTS
Compared with the normal men, the schizophrenic patients had lower relative metabolic rates in the anterior cingulate and higher rates in the posterior cingulate.


CONCLUSIONS
The findings suggest hypofunction in the anterior cingulate cortex in schizophrenia.
Haznedar
M M
MM
Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029-6574, USA.
Buchsbaum
M S
MS
Luu
C
C
Hazlett
E A
EA
Siegel
B V
BV
Lohr
J
J
Wu
J
J
Haier
R J
RJ
Bunney
W E
WE
D000293:Adolescent; D000328:Adult; D003847:Deoxyglucose / Q000031:analogs & derivatives; D019788:Fluorodeoxyglucose F18; D005947:Glucose / Q000378:metabolism*; D006179:Gyrus Cinguli / Q000000981:diagnostic imaging / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012559:Schizophrenia / Q000000981:diagnostic imaging / Q000378:metabolism*; D014055:Tomography, Emission-Computed
D019788:Fluorodeoxyglucose F18; D003847:Deoxyglucose; D005947:Glucose