title: Dimensional complexity of EEG waveforms in neuroleptic-free schizophrenic patients and normal control subjects.
abstract: Dimensional complexity reflects the number of independent variables contributing to a dynamic process. EEG epochs recorded from 12 neuroleptic-free schizophrenic patients and 11 normal control subjects were Laplacian-filtered to highlight activity specific to prefrontal and parietal areas, and dimensional complexity measures of the resulting signals were then derived. Complexity of EEG waveforms generated by schizophrenic patients was depressed relative to that of normal subjects, especially in left frontal and right parietal regions. These data suggest that complexity of underlying is also reduced.
authors.affiliation: Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA.
authors.forename: R E
authors.initials: RE
authors.lastname: Hoffmann
authors.forename: M S
authors.initials: MS
authors.lastname: Buchsbaum
authors.forename: R V
authors.initials: RV
authors.lastname: Jensen
authors.forename: S M
authors.initials: SM
authors.lastname: Guich
authors.forename: K
authors.initials: K
authors.lastname: Tsai
authors.forename: K H
authors.initials: KH
authors.lastname: Nuechterlein
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000494:pharmacology; D001921:Brain / Q000187:drug effects / Q000502:physiology / Q000503:physiopathology*; D004569:Electroencephalography; D006801:Humans; D012559:Schizophrenia / Q000503:physiopathology*
chemical_list: D014150:Antipsychotic Agents