Mortality among benzene-exposed workers in China.
A large cohort of 74,828 benzene-exposed and 35,805 nonexposed workers employed between 1972 and 1987 in 12 cities in China was followed to determine mortality from all causes. Benzene-exposed study subjects were employed in a variety of occupations including coating applications, and rubber, chemical, and shoe production. Mortality was slightly increased among workers with greater cumulative exposure to benzene (ptrend < 0.05), but this excess was largely due to cancer deaths (ptrend < 0.01). Deaths due to lymphatic and hematopoietic malignancies (ptrend = 0.01) and lung cancer (ptrend = 0.01) increased with increasing cumulative exposure to benzene. Investigations continue to relate benzene exposure to specific lymphatic and hematopoietic malignancies and other causes of death.
Hayes
R B
RB
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-7368, USA. hayesr@epndce.nci.nih.gov
Yin
S N
SN
Dosemeci
M
M
Li
G L
GL
Wacholder
S
S
Chow
W H
WH
Rothman
N
N
Wang
Y Z
YZ
Dai
T R
TR
Chao
X J
XJ
Jiang
Z L
ZL
Ye
P Z
PZ
Zhao
H B
HB
Kou
Q R
QR
Zhang
W Y
WY
Meng
J F
JF
Zho
J S
JS
Lin
X F
XF
Ding
C Y
CY
Li
C Y
CY
Zhang
Z N
ZN
Li
D G
DG
Travis
L B
LB
Blot
W J
WJ
Linet
M S
MS
D001554:Benzene / Q000633:toxicity*; D002681:China / Q000453:epidemiology; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007938:Leukemia / Q000139:chemically induced / Q000401:mortality; D008175:Lung Neoplasms / Q000139:chemically induced / Q000401:mortality; D008223:Lymphoma / Q000139:chemically induced / Q000401:mortality; D008297:Male; D009369:Neoplasms / Q000139:chemically induced / Q000401:mortality; D009784:Occupational Diseases / Q000139:chemically induced* / Q000401:mortality*; D016273:Occupational Exposure; D012307:Risk Factors
D001554:Benzene