title: An expanded cohort study of cancer among benzene-exposed workers in China. Benzene Study Group.
abstract: An expanded cohort study of 74,828 benzene-exposed and 35,805 unexposed workers were followed during 1972 to 1987, based on a previous study in 12 cities in China. A small increase was observed in total cancer mortality among benzene-exposed compared with unexposed workers (relative risk [RR] = 1.2). Statistically significant excesses were noted for leukemia (RR = 2.3), malignant lymphoma (RR = 4.5), and lung cancer (RR = 1.4). When risks were evaluated by leukemia subtype, only acute myelogenous leukemia was significantly elevated (RR = 3.1), although nonsignificant excesses were also noted for chronic myelogenous leukemia (RR = 2.6) and acute lymphocytic leukemia (RR = 2.3). A significant excess was also found for aplastic anemia.
authors.affiliation: Chinese Academy of Preventive Medicine, Bejing, China. yinsn@public3.bta.net.cn
authors.forename: S N
authors.initials: SN
authors.lastname: Yin
authors.forename: R B
authors.initials: RB
authors.lastname: Hayes
authors.forename: M S
authors.initials: MS
authors.lastname: Linet
authors.forename: G L
authors.initials: GL
authors.lastname: Li
authors.forename: M
authors.initials: M
authors.lastname: Dosemeci
authors.forename: L B
authors.initials: LB
authors.lastname: Travis
authors.forename: Z N
authors.initials: ZN
authors.lastname: Zhang
authors.forename: D G
authors.initials: DG
authors.lastname: Li
authors.forename: W H
authors.initials: WH
authors.lastname: Chow
authors.forename: S
authors.initials: S
authors.lastname: Wacholder
authors.forename: W J
authors.initials: WJ
authors.lastname: Blot
mesh_terms: D000741:Anemia, Aplastic / Q000139:chemically induced / Q000453:epidemiology; D001554:Benzene / Q000633:toxicity*; D002273:Carcinogens / Q000633:toxicity; D002681:China / Q000453:epidemiology; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007938:Leukemia / Q000139:chemically induced / Q000401:mortality; D015470:Leukemia, Myeloid, Acute / Q000139:chemically induced / Q000401:mortality; D008175:Lung Neoplasms / Q000139:chemically induced / Q000401:mortality; D008223:Lymphoma / Q000139:chemically induced / Q000401:mortality; D008297:Male; D009190:Myelodysplastic Syndromes / Q000139:chemically induced / Q000453:epidemiology; D009369:Neoplasms / Q000139:chemically induced* / Q000401:mortality; D009784:Occupational Diseases / Q000139:chemically induced / Q000453:epidemiology / Q000401:mortality; D016273:Occupational Exposure; D012307:Risk Factors
chemical_list: D002273:Carcinogens; D001554:Benzene