title: Comparison of proliferating cell nuclear antigen index in benign and malignant salivary pleomorphic adenoma.
abstract: The expression of proliferating cell nuclear antigen (PCNA) was studied in benign and malignant pleomorphic adenomas by using monoclonal antibody to PCNA. Carcinoma in pleomorphic adenoma (n = 8), cell-rich variant (n = 6) and typical pleomorphic adenoma (n = 6) were selected in this study. The PCNA index in carcinoma in pleomorphic adenoma showed a higher index of nuclear staining (mean 22.9%, S.D. 6.2) than in typical pleomorphic adenoma (mean 6.9%, S.D. 3.4) or a cell-rich variant of pleomorphic adenoma (mean 8.8%, S.D. 3.3). A significant difference in PCNA index was found between benign and malignant pleomorphic adenoma (P < 0.05). The present study suggests that PCNA index significantly differs between pleomorphic adenoma and carcinoma in pleomorphic adenoma, but in the prediction of malignant transformation potential it should be combined with routine histopathological examination.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Asahi University School of Dentistry, Gifu, Japan.
authors.forename: L
authors.initials: L
authors.lastname: Yang
authors.forename: B
authors.initials: B
authors.lastname: Liu
authors.forename: C
authors.initials: C
authors.lastname: Qin
authors.forename: K
authors.initials: K
authors.lastname: Hashimura
authors.forename: T
authors.initials: T
authors.lastname: Yamada
authors.forename: S
authors.initials: S
authors.lastname: Sumitomo
authors.forename: M
authors.initials: M
authors.lastname: Mori
mesh_terms: D008949:Adenoma, Pleomorphic / Q000145:classification / Q000473:pathology*; D000911:Antibodies, Monoclonal; D015415:Biomarkers; D002277:Carcinoma / Q000473:pathology; D004396:Coloring Agents; D004801:Eosine Yellowish-(YS); D006416:Hematoxylin; D006801:Humans; D007150:Immunohistochemistry; D018809:Proliferating Cell Nuclear Antigen / Q000032:analysis*; D012468:Salivary Gland Neoplasms / Q000145:classification / Q000473:pathology*
chemical_list: D000911:Antibodies, Monoclonal; D015415:Biomarkers; D004396:Coloring Agents; D018809:Proliferating Cell Nuclear Antigen; D004801:Eosine Yellowish-(YS); D006416:Hematoxylin