DNA excision repair pathways.
The major DNA excision repair pathways of base excision repair for endogenous DNA lesions and nucleotide excision repair for DNA damage inflicted by ultraviolet light have been reconstructed with purified mammalian proteins and details of these repair mechanisms are emerging. Similar data are becoming available with regard to mismatch repair for correction of replication errors. Deletion of individual DNA repair proteins in knockout mice provides information on the roles of such factors in vivo and recent three-dimensional structures of several repair enzymes explain their detailed modes of action.
Lindahl
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Imperial Cancer Research Fund, Clare Hall Laboratories, Blanche Lane, South Mimms, Hertfordshire, EN6 3LD, UK.
Karran
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Wood
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D000818:Animals; D003057:Cockayne Syndrome / Q000235:genetics; D004265:DNA Helicases / Q000378:metabolism; D004260:DNA Repair; D045643:DNA Repair Enzymes; D004268:DNA-Binding Proteins; D006801:Humans; D051379:Mice; D009692:Nucleic Acid Heteroduplexes; D000075223:Poly-ADP-Ribose Binding Proteins; D011506:Proteins / Q000378:metabolism; D014157:Transcription Factors; D014158:Transcription, Genetic
C490652:Ckn1 protein, mouse; D004268:DNA-Binding Proteins; C095472:ERCC8 protein, human; D009692:Nucleic Acid Heteroduplexes; D000075223:Poly-ADP-Ribose Binding Proteins; D011506:Proteins; D014157:Transcription Factors; D004265:DNA Helicases; C078673:ERCC6 protein, human; C513075:Ercc6 protein, mouse; D045643:DNA Repair Enzymes