title: The development of nonpeptide angiotensin II receptor antagonists: a success story.
abstract: The modulation of the renin-angiotensin system continues to be an important target in drug design. The development of nonpeptide angiotensin II receptor antagonists offers a new tool in treatment of hypertension. Starting from benzimidazole lead structures detailed structure-activity analyses, molecular modeling methods, and dedicated syntheses led to the development of potent, orally active antihypertensive drugs.
authors.affiliation: Institute for Pharmaceutical Chemistry, Heinrich-Heine-University Düsseldorf, Germany.
authors.forename: H D
authors.initials: HD
authors.lastname: Höltje
authors.forename: G
authors.initials: G
authors.lastname: Jessen
authors.forename: M
authors.initials: M
authors.lastname: Höltje
mesh_terms: D000804:Angiotensin II / Q000378:metabolism*; D057911:Angiotensin Receptor Antagonists; D000818:Animals; D006801:Humans; D012084:Renin-Angiotensin System / Q000187:drug effects / Q000502:physiology
chemical_list: D057911:Angiotensin Receptor Antagonists; D000804:Angiotensin II