Regeneration of articular cartilage defects in rabbits by osteogenic protein-1 (bone morphogenetic protein-7).
Osteogenic protein-1 (OP-1, BMP-7), a member of the transforming growth factor-beta family, induces cartilage and bone formation when implanted at intra and extraskeletal sites in vivo. The human OP-1 gene has been cloned and biologically active recombinant OP-1 homodimers have been produced. In the present study, the authors investigated the influence of OP-1 on healing of full-thickness articular cartilage defects, made by drilling two adjacent (phi 3mm) holes through articular cartilage of NZW rabbit knee joint were dissected and examined histomorphometrically. Results indicated that OP-1 induced articular cartilage healing and regeneration of the joint surface which contained cells resembling mature joint chondrocytes. These data imply a new strategy for biological repair of damaged joint surfaces in humans.
Grgić
M
M
Drago Perović Institute of Anatomy, School of Medicine, University of Zagreb, Croatia.
Jelić
M
M
Basić
V
V
Basić
N
N
Pećina
M
M
Vukicević
S
S
D000818:Animals; D055419:Bone Morphogenetic Protein 7; D019485:Bone Morphogenetic Proteins / Q000494:pharmacology*; D002358:Cartilage, Articular / Q000473:pathology / Q000502:physiology*; D007719:Knee Joint; D011817:Rabbits; D012038:Regeneration; D016212:Transforming Growth Factor beta / Q000494:pharmacology; D014945:Wound Healing
C525819:BMP7 protein, human; D055419:Bone Morphogenetic Protein 7; D019485:Bone Morphogenetic Proteins; D016212:Transforming Growth Factor beta