title: Proliferative activity of central neurocytoma: measurement of tumor volume doubling time, MIB-1 staining index and bromodeoxyuridine labeling index.
abstract: Central neurocytoma is considered to be a benign intracranial neoplasm, but little is known about the biological behavior of this type of tumor. Proliferative activity of central neurocytoma was measured in 10 cases using MIB-1 staining for Ki-67 antigen. The MIB-1 staining value varied from < 0.1% to 5.6%, to indicating that some of these tumors have proliferative potential similar to that of anaplastic astrocytoma or malignant meningioma. The bromodeoxyuridine labeling index (BUdR LI, BrdU LI) was measured in 2 cases and the results correlated well with those of the MIB-1 analysis. Tumor volume doubling time (Td) measured in one case was 358 days which is similar to that of malignant meningioma. In one case, the MIB-1 value taken before and after 58 Gy of radiation treatment decreased markedly from 5.6% to 0.2%. The other 9 cases were also treated by radiation therapy (50-60 Gy) and no tumor recurrence was observed during follow-up periods ranging from 23 to 160 months. Another two patients with partially removed and 3 with subtotally removed tumors showing relatively high MIB-1 values might also have benefited from radiation therapy.
authors.affiliation: Department of Neurosurgery, University of Tokyo Hospital, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Fujimaki
authors.forename: A
authors.initials: A
authors.lastname: Matsuno
authors.forename: T
authors.initials: T
authors.lastname: Sasaki
authors.forename: T
authors.initials: T
authors.lastname: Toyoda
authors.forename: R
authors.initials: R
authors.lastname: Matsuura
authors.forename: M
authors.initials: M
authors.lastname: Ogai
authors.forename: C
authors.initials: C
authors.lastname: Kitanaka
authors.forename: A
authors.initials: A
authors.lastname: Asai
authors.forename: M
authors.initials: M
authors.lastname: Matsutani
authors.forename: T
authors.initials: T
authors.lastname: Kirino
mesh_terms: D000328:Adult; D000911:Antibodies, Monoclonal; D001932:Brain Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000532:radiotherapy; D001973:Bromodeoxyuridine; D002455:Cell Division; D005260:Female; D006801:Humans; D019394:Ki-67 Antigen / Q000276:immunology; D008279:Magnetic Resonance Imaging; D008297:Male; D018306:Neurocytoma / Q000000981:diagnostic imaging / Q000473:pathology* / Q000532:radiotherapy; D013194:Staining and Labeling; D014057:Tomography, X-Ray Computed
chemical_list: D000911:Antibodies, Monoclonal; D019394:Ki-67 Antigen; D001973:Bromodeoxyuridine