Evidence of a predisposing locus to bipolar disorder on Xq24-q27.1 in an extended Finnish pedigree.
An X-chromosomal predisposing locus to manic-depressive illness has been suggested since 1969 on the basis of the cosegregation of this trait in some families with phenotypic markers, such as color blindness, the glucose-6-phosphate dehydrogenase deficiency, and the coagulation factor IX deficiency. However, the conclusive evidence and the exact location of the putative X-chromosomal locus have remained controversial. We report here a linkage between DNA markers near the coagulation factor IX gene and bipolar disorder in an extended pedigree rising from the genetically isolated population of Finland. A distinct chromosomal haplotype covering a 20-cM region on Xq24-q27.1 could be demonstrated to segregate with bipolar disorder. These findings should encourage research groups to study extended family materials with Xq24-q27.1 markers to finally resolve the question of the X-chromosomal linkage of bipolar disorder.
Pekkarinen
P
P
Department of Human Molecular Genetics, National Public Health Institute, Helsinki, Finland. petra.pekkarinen@ktl.fi.
Terwilliger
J
J
Bredbacka
P E
PE
Lönnqvist
J
J
Peltonen
L
L
D001483:Base Sequence; D001714:Bipolar Disorder / Q000235:genetics*; D002874:Chromosome Mapping; D017931:DNA Primers; D005260:Female; D005387:Finland; D006239:Haplotypes; D006801:Humans; D007041:Hypoxanthine Phosphoribosyltransferase / Q000235:genetics; D008297:Male; D008969:Molecular Sequence Data; D010375:Pedigree; D014960:X Chromosome
D017931:DNA Primers; D007041:Hypoxanthine Phosphoribosyltransferase