title: Skull metastasis with brain invasion from thyroid papillary microcarcinoma.
abstract: Thyroid papillary microcarcinoma has a notably benign clinical course among carcinomas. The occurrence of distant metastases is exceptional, but significantly increases the risk of mortality. We report the case of a 75-year-old woman with a 1.0 cm primary thyroid papillary microcarcinoma with skull metastases and brain invasion. The clinical presentation was a large mass over the occipital area which progressively grew over the course of 1 year. No thyroid nodule or lymph nodes were palpable. The metastatic mass and primary tumor were surgically removed. The serum thyroglobulin level was 163 ng/mL 1 month after surgery. There was no further management because the patient refused follow-up. She returned to the hospital 15 months later due to a seizure. The tumor had further extended into the brain tissue. Her condition progressively deteriorated and she died 2 months later due to uncontrollable seizures.
authors.affiliation: Department of Internal Medicine, Chang Gung Medical Center, Linkou, ROC.
authors.forename: K D
authors.initials: KD
authors.lastname: Lin
authors.forename: J D
authors.initials: JD
authors.lastname: Lin
authors.forename: H S
authors.initials: HS
authors.lastname: Huang
authors.forename: L B
authors.initials: LB
authors.lastname: Jeng
authors.forename: Y S
authors.initials: YS
authors.lastname: Ho
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor; D002291:Carcinoma, Papillary / Q000097:blood / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D012888:Skull Neoplasms / Q000556:secondary* / Q000601:surgery; D013954:Thyroglobulin / Q000097:blood; D013964:Thyroid Neoplasms / Q000097:blood / Q000473:pathology* / Q000601:surgery; D013965:Thyroidectomy
chemical_list: D014408:Biomarkers, Tumor; D013954:Thyroglobulin