Pathogenesis and management of bone lesions in multiple myeloma.
Osteolytic lesions are among the hallmarks of multiple myeloma (MM). On the other hand, they are rare in B cell malignancies other than MM. Data have shown a close relationship between myeloma cell growth factors and factors involved in the occurrence of bone lesions in MM. Biophosphonates, which are potent inhibitors of bone resorption to control MM-induced hypercalcemia, are of interest due to their ability to slow the progression of MM bone disease.
Bataille
R
R
Institute of Biology, Nantes, France.
Manolagas
S C
SC
Berenson
J R
JR
D001859:Bone Neoplasms / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D006801:Humans; D009101:Multiple Myeloma / Q000473:pathology / Q000503:physiopathology / Q000628:therapy