[Determination of intercellular adhesion molecule-1 (ICAM-1) in nasal secretions of patients with rhinitis].
Intercellular adhesion molecule-1 (ICAM-1) is an integrin involved in the regulation of cell migration and activation in various tissues. ICAM-1 expression has been shown to be associated closely with cell infiltration in allergic diseases. We analyzed the possible participation of soluble ICAM-1 (sICAM-1) in the pathogenesis of various diseases of the nasal mucosa by measuring sICAM-1 levels in nasal secretions using sandwich ELISA. Soluble ICAM-1 levels in patients with allergic rhinitis and nasal polyposis did not increase with respect to healthy controls, but patients with chronic sinusitis had higher sICAM-1 levels. Soluble ICAM-1 levels also increased in patients with allergic rhinitis after a provocation test with the specific allergen. These results show that ICAM-1 is involved in the pathogenesis of chronic sinusitis and allergic rhinitis.
Bujía
J
J
Departamento de ORL, Universidad Ludwig-Maximilians de Munich.
Rasp
G
G
D000328:Adult; D002465:Cell Movement; D002908:Chronic Disease; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D016023:Integrins / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D009297:Nasal Mucosa / Q000737:chemistry* / Q000378:metabolism / Q000503:physiopathology; D009298:Nasal Polyps / Q000175:diagnosis / Q000503:physiopathology; D009299:Nasal Provocation Tests; D006255:Rhinitis, Allergic, Seasonal / Q000175:diagnosis* / Q000503:physiopathology; D012852:Sinusitis / Q000175:diagnosis
D016023:Integrins