title: Lactate transport across the bovine rumen epithelium in vitro.
abstract: The in vitro transport of L-lactate across rumen epithelium was found to be a passive, mass-action regulated diffusion, and no saturable transport mechanisms were involved at concentrations from 2-20 mmol/L. During this increase in L-lactate concentrations the epithelial resistance and potential difference increased significantly, indicating an epithelial change towards a more tight epithelium. The net sodium transport was significantly reduced by 45% at 20 mmol/L lactate as compared to lactate free conditions.
authors.affiliation: Department of Animal Physiology, Royal Veterinary and Agricultural University, Copenhagen, Denmark.
authors.forename: P D
authors.initials: PD
authors.lastname: Møller
authors.forename: L
authors.initials: L
authors.lastname: Diernaes
authors.forename: J
authors.initials: J
authors.lastname: Sehested
authors.forename: J
authors.initials: J
authors.lastname: Hyldgaard-Jensen
authors.forename: E
authors.initials: E
authors.lastname: Skadhauge
mesh_terms: D000818:Animals; D001692:Biological Transport / Q000187:drug effects / Q000502:physiology; D002417:Cattle / Q000378:metabolism* / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D004848:Epithelium / Q000378:metabolism / Q000502:physiology; D066298:In Vitro Techniques; D007773:Lactates / Q000378:metabolism / Q000493:pharmacokinetics* / Q000494:pharmacology; D012044:Regression Analysis; D012417:Rumen / Q000378:metabolism* / Q000502:physiology; D012964:Sodium / Q000378:metabolism / Q000493:pharmacokinetics
chemical_list: D007773:Lactates; D012964:Sodium