Brain energy metabolism, cognitive function and down-regulated oxidative phosphorylation in Alzheimer disease.
Reduced brain glucose utilization in early stages of Alzheimer disease, as measured with in vivo positron emission tomography, reflects potentially reversible down-regulation of gene expression for oxidative phosphorylation within neuronal mitochondria. Such down-regulation may occur when neuronal energy demand is first reduced by synaptic dysfunction or loss.
Rapoport
S I
SI
Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA. sir@helix.nih.gov
Hatanpää
K
K
Brady
D R
DR
Chandrasekaran
K
K
D000544:Alzheimer Disease / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000503:physiopathology; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000503:physiopathology; D003071:Cognition; D004734:Energy Metabolism; D006801:Humans; D010085:Oxidative Phosphorylation; D014055:Tomography, Emission-Computed