An interactive Web site providing major histocompatibility ligand predictions: application to HIV research.
EpiMatrix/HIV, a tool that is currently available on the World Wide Web, enables researchers to screen HIV proteins for potential MHC ligands. We have performed a comparison of EpiMatrix predictions to 158 published allotype-specific HLA-associated peptides (MHC ligands) derived from 133 proteins. The top 10 ranked EpiMatrix predictions for each of the 158 HLA allotype-protein pairs were selected for comparison with these published ligands. EpiMatrix correctly identified 134 of 158 published ligands (85%). The algorithm is now available for use by the HIV research community at the URL http:/(/)www.EpiMatrix.com/HIV.
De Groot
A S
AS
TB/HIV Research Laboratory, Brown University School of Medicine, Providence, Rhode Island 02912, USA.
Jesdale
B M
BM
Szu
E
E
Schafer
J R
JR
Chicz
R M
RM
Deocampo
G
G
D003195:Computer Communication Networks / Q000458:organization & administration; D001330:Electronic Data Processing; D015658:HIV Infections / Q000276:immunology*; D006680:HLA Antigens / Q000276:immunology; D006801:Humans; D008285:Major Histocompatibility Complex / Q000276:immunology*; D010455:Peptides / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
D006680:HLA Antigens; D010455:Peptides