title: Immediate breast reconstruction in patients with locally advanced disease.
abstract: Immediate breast reconstruction for patients with early-stage disease is well established. This study evaluates a consecutive series of 22 patients with locally advanced disease (stage IIB or III) who underwent mastectomy and immediate breast reconstruction. All patients received several cycles of neoadjuvant chemotherapy (average, 3.5 cycles) followed by completion of chemotherapy beginning approximately 3 weeks following surgery. The perioperative morbidity was 14% and no patient suffered a delay in the resumption of chemotherapy. Patients have been particularly grateful about being offered reconstruction in this setting. Our preliminary results with this technique have been encouraging and further study is warranted.
authors.affiliation: Columbia Presbyterian Medical Center, New York, NY USA.
authors.forename: M R
authors.initials: MR
authors.lastname: Sultan
authors.forename: M L
authors.initials: ML
authors.lastname: Smith
authors.forename: A
authors.initials: A
authors.lastname: Estabrook
authors.forename: F
authors.initials: F
authors.lastname: Schnabel
authors.forename: D
authors.initials: D
authors.lastname: Singh
mesh_terms: D000328:Adult; D018427:Breast Implants; D001943:Breast Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016462:Mammaplasty / Q000379:methods*; D008875:Middle Aged; D009367:Neoplasm Staging; D011183:Postoperative Complications / Q000209:etiology; D012189:Retrospective Studies; D013524:Surgical Flaps; D015625:Tissue Expansion Devices