The role of Src family kinases in the normal and neoplastic gastrointestinal tract.
Src family kinases are a group of non-receptor tyrosine kinases that mediate signal transduction pathways involved in the growth and differentiation of normal tissues. Considerable evidence exists for a role of these proteins in neoplastic progression in various organ systems including the nervous, hematopoietic and skeletal systems. In addition, the role of the Src kinase family has been characterized for colon cancer, but only limited progress has been made in delineating the role of Src kinases in the normal gastrointestinal (GI) tract and extracolonic GI cancers. In this review, we provide an up-to-date assessment of the Src family kinases in the normal and neoplastic GI tract.
Banker
N
N
Department of Surgery, The University of Texas Medical Branch, Galveston 77555-0527, USA.
Evers
B M
BM
Hellmich
M R
MR
Townsend
C M
CM
D014408:Biomarkers, Tumor / Q000032:analysis / Q000096:biosynthesis*; D004064:Digestive System / Q000201:enzymology*; D005770:Gastrointestinal Neoplasms / Q000175:diagnosis / Q000201:enzymology*; D006801:Humans; D012680:Sensitivity and Specificity; D015398:Signal Transduction / Q000502:physiology; D019061:src-Family Kinases / Q000378:metabolism* / Q000502:physiology
D014408:Biomarkers, Tumor; D019061:src-Family Kinases