title: Characteristics of hypoxemic episodes in very low birth weight infants on ventilatory support.
abstract: OBJECTIVE
  To characterize hypoxemic episodes in very low birth weight infants with mechanically ventilated lungs and to describe their natural history and the effect of body position.
  
  
  METHODS
  Tidal volume, respiratory rate, oxygen saturation, heart rate, and body movement were continuously recorded in 10 very low birth weight infants who exhibited episodes of hypoxemia during mechanical ventilation (birth weight, 810 +/- 133 gm; postconceptional age at study, 30 +/- 1.6 weeks). Frequency of hypoxemic episodes was compared in both prone and supine positions.
  
  
  RESULTS
  Seventy-eight percent of hypoxemic episodes began in association with body movement as well as heart rate acceleration. Thereafter the spontaneous and delivered minute ventilation both decreased during the first 15 seconds of hypoxemia. The former decrease was due to a significant decrease in frequency of spontaneous respiration, whereas the latter was associated with a significant decrease in delivered tidal volume. Minute ventilation returned to normal before recovery of oxygenation. A change in body position from supine to prone significantly decreased the frequency of hypoxemic episodes.
  
  
  CONCLUSIONS
  Hypoxemic episodes in infants who are on ventilatory support are characterized by (1) movement and cardioacceleration at initiation; (2) a decrease in both spontaneous and delivered minute ventilation, and (3) a lower incidence in the prone position. We speculate that spontaneous movement during sleep can trigger cardiopulmonary reflex responses that initiate and propagate these episodes.
authors.affiliation: Department of Pediatrics, Rainbow Babies and Childrens Hospital, Case Western Reserve University, Cleveland, Ohio, USA.
authors.forename: M A
authors.initials: MA
authors.lastname: Dimaguila
authors.forename: J M
authors.initials: JM
authors.lastname: Di Fiore
authors.forename: R J
authors.initials: RJ
authors.lastname: Martin
authors.forename: M J
authors.initials: MJ
authors.lastname: Miller
mesh_terms: D006339:Heart Rate; D006801:Humans; D000860:Hypoxia / Q000097:blood / Q000503:physiopathology*; D007231:Infant, Newborn; D019102:Infant, Very Low Birth Weight; D009068:Movement; D011187:Posture; D012121:Respiration, Artificial; D015656:Respiratory Mechanics