title: Feasibility of the grandprogeny design for quantitative trait loci (QTL) detection in purebred beef cattle.
abstract: The grandprogeny design (GPD) was developed for dairy cattle to use existing pedigreed populations for quantitative trait locus (QTL) detection. Marker genotypes of grandsires and sons are determined, and trait phenotypic data from grandprogeny are analyzed. The objective of this study was to investigate the potential application of GPD in purebred beef cattle populations. Pedigree structures of Angus (n = 123,319), Hereford (n = 107,778), Brangus (n = 14,449), and Gelbvieh (n = 8,114) sire evaluation reports were analyzed to identify potentially useful families. Power of QTL detection was calculated for a range of QTL effects (.1 to .5 SD) and two Type I error rates (.01 and .001). Reasonable power (> .75) could be achieved using GPD in Angus and Hereford for QTL having moderate effects (.3 SD) on weaning weight and large effects (.4 to .5 SD) on birth, yearling, and maternal weaning weights by genotyping 500 animals. Existing Gelbvieh and Brangus families useful for GPD were limited, and reasonable power could be expected only for QTL having large effects on weaning or birth weights. Although family structures suitable for GPD exist in purebred beef populations, large amounts of genotyping would be required to achieve reasonable power, and only QTL having moderate to large effects could be expected to be identified.
authors.affiliation: Department of Animal Science, University of Nebraska, Lincoln 68583-0908, USA.
authors.forename: D E
authors.initials: DE
authors.lastname: Moody
authors.forename: D
authors.initials: D
authors.lastname: Pomp
authors.forename: D S
authors.initials: DS
authors.lastname: Buchanan
mesh_terms: D000375:Aging / Q000502:physiology; D000818:Animals; D001724:Birth Weight / Q000502:physiology; D001835:Body Weight / Q000502:physiology; D001947:Breeding; D002417:Cattle / Q000235:genetics* / Q000502:physiology; D002874:Chromosome Mapping; D005260:Female; D005838:Genotype; D008297:Male; D010375:Pedigree; D010641:Phenotype