title: Renal effects of dopamine infusion in conscious horses.
abstract: An ultrasonic flow probe was implanted around a branch of the left renal artery in five horses. The effects of dopamine were studied in the unsedated horses 10 days after surgery. Three experiments, separated by at least two days, were performed in random order on each horse. In two experiments, dopamine was infused intravenously for 60 mins at either 2.5 and 5.0 micrograms/kg bodyweight (bwt)/min. Saline was infused for 60 mins before and after each infusion, and for 180 mins in the third experiment as a control. Renal blood flow increased during administration of dopamine at both dose rates (P = 0.0001). Urine volume increased (P = 0.055), and osmolality decreased (P < 0.05), with infusion of dopamine at 5.0 micrograms/kg bwt/min. Arterial blood pressure and heart rate were not significantly affected. Fractional excretions of sodium and potassium were not significantly changed with dopamine infusion. The higher dopamine dose rate was accompanied by dysrhythmias in some horses.
authors.affiliation: Department of Large Animal Medicine, College of Veterinary Medicine, University of Georgia, Athens 30602, USA.
authors.forename: C M
authors.initials: CM
authors.lastname: Trim
authors.forename: J N
authors.initials: JN
authors.lastname: Moore
authors.forename: E S
authors.initials: ES
authors.lastname: Clark
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D003243:Consciousness / Q000502:physiology*; D003404:Creatinine / Q000097:blood; D004298:Dopamine / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology; D006736:Horses / Q000502:physiology*; D007262:Infusions, Intravenous / Q000662:veterinary; D007668:Kidney / Q000098:blood supply / Q000187:drug effects* / Q000502:physiology; D009994:Osmolar Concentration; D011188:Potassium / Q000097:blood; D011897:Random Allocation; D012039:Regional Blood Flow / Q000187:drug effects / Q000502:physiology; D012077:Renal Artery / Q000000981:diagnostic imaging / Q000187:drug effects / Q000502:physiology; D012964:Sodium / Q000097:blood; D013997:Time Factors; D014463:Ultrasonography / Q000379:methods / Q000662:veterinary; D014554:Urination / Q000502:physiology
chemical_list: D012964:Sodium; D003404:Creatinine; D011188:Potassium; D004298:Dopamine