Ciliostatic effect of fungi on the respiratory tract ciliary movement of one-day-old chickens in vitro.
The ciliostatic activity of exo- and endometabolites of 243 filamentous fungal strains was evaluated by in vitro bioassay using tracheal organ cultures of 1-d-old chicks. Chloroform-extractable metabolites produced in the cultivation medium (25 degrees C/10 d) by 30 out of 72 (41%) investigated strains displayed the ciliostatic activity as did metabolites from the biomass of the spores and the mycelium of 46 other strains (26%). This result could contribute to the clarification of the correlation between fungi and respiratory disorders in some working places and in damp dwellings.
Piecková
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E
Institute of Preventive and Clinical Medicine, Institute of Preventive and Clinical Medicine, Bratislava, Stovakia.
Jesenská
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Z
D000818:Animals; D002645:Chickens; D002725:Chloroform; D002923:Cilia / Q000187:drug effects* / Q000502:physiology; D003864:Depression, Chemical; D004781:Environmental Exposure; D004848:Epithelium / Q000187:drug effects / Q000503:physiopathology / Q000648:ultrastructure; D005658:Fungi / Q000737:chemistry*; D006801:Humans; D009068:Movement; D009183:Mycotoxins / Q000302:isolation & purification / Q000494:pharmacology*; D018877:Sick Building Syndrome / Q000382:microbiology; D012997:Solvents; D014132:Trachea / Q000187:drug effects* / Q000503:physiopathology / Q000648:ultrastructure
D009183:Mycotoxins; D012997:Solvents; D002725:Chloroform