[Proliferation mechanisms of normal and cancerous cells].
A morphometric study of the basal layer of the epithelium has established the following cell patterns: round, oval, transitional, elongated and narrow. Also, cell peaks 1, 2, A, B and C have been identified. Some oval (peak 1) cells became elongated during proliferation. After the latter cell fraction accounted for 30% of the total cell population 5% became round thus contributing to the peak C fraction, and entered mitosis. It took place when a full equilibrium between the peak A and B fractions in the oval cell population had been reached. Populations of lung cancer cells revealed identical patterns and peaks while the pattern of cell fraction redistribution during entry into mitosis was similar to that of normal corneal epithelium. The rate of cell pattern redistribution in tumor tissue was found to be much higher than that of normal epithelium.
Iavisheva
T M
TM
Iagubov
A S
AS
D000818:Animals; D002455:Cell Division; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D004728:Endothelium, Corneal / Q000166:cytology; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008938:Mitosis