The culture fluid of Isaira japonica yasuda augments anti-sheep red blood cell antibody response in mice.
Isaria japonica YASUDA was cultured in a liquid medium, and its culture fluid (IJCE) was tested for stimulatory activity to humoral antibody production. IJCE significantly enhanced the production of anti-sheep red blood cell (SRBC) plaque forming cells (PFC) by oral ingestions at 10 and 30 mg/kg/d for 4 consecutive days, either before or after SRBC challenge. It also recovered the reduction of anti-SRBC PFC response and number of spleen cells caused by treatment with 5-fluorouracil. It is suggested that IJCE is a promising source for an immunomodulating tool or medicine.
Takano
F
F
Faculty of Pharmaceutical Sciences, Tohoku University, Japan.
Kikuchi
Y
Y
Fushiya
S
S
Hojo
H
H
Nozoe
S
S
Yahagi
N
N
Yahagi
R
R
Kondo
Y
Y
D000276:Adjuvants, Immunologic / Q000494:pharmacology; D000818:Animals; D000906:Antibodies / Q000276:immunology / Q000378:metabolism*; D000917:Antibody Formation; D002452:Cell Count / Q000187:drug effects; D002478:Cells, Cultured; D003470:Culture Media; D004912:Erythrocytes / Q000276:immunology*; D005658:Fungi / Q000378:metabolism*; D007114:Immunization; D008214:Lymphocytes / Q000187:drug effects; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009929:Organ Size / Q000187:drug effects; D012756:Sheep; D013154:Spleen / Q000276:immunology / Q000378:metabolism; D014529:Uridine / Q000031:analogs & derivatives / Q000494:pharmacology
D000276:Adjuvants, Immunologic; D000906:Antibodies; D003470:Culture Media; C001943:5-fluorouridine; D014529:Uridine