title: Current status of low density lipoprotein-apheresis for the therapy of severe hyperlipidemia.
abstract: The use of LDL-apheresis to treat patients with severe hypercholesterolemia has gained wider clinical acceptance during the past 2-3 years, particularly in patients with coronary artery disease. Systems utilizing immunoadsorption columns, dextran sulfate cellulose columns and heparin precipitation have been most commonly employed. New or improved technologies include whole-blood compatible columns, double-filtration plasmapheresis and lipoprotein (a)-apheresis. The mechanisms for clinical improvement extend beyond simple regression of atherosclerotic plaque.
authors.affiliation: Rogosin Institute, New York Hospital-Cornell Medical Center, New York 10021, USA.
authors.forename: B R
authors.initials: BR
authors.lastname: Gordon
authors.forename: S D
authors.initials: SD
authors.lastname: Saal
mesh_terms: D001781:Blood Component Removal; D002986:Clinical Trials as Topic; D006801:Humans; D006937:Hypercholesterolemia / Q000628:therapy*; D008077:Lipoproteins, LDL / Q000097:blood / Q000302:isolation & purification*; D016896:Treatment Outcome
chemical_list: D008077:Lipoproteins, LDL