Protein proteinase inhibitors from avian egg whites.
Avian egg whites are a rich source of protein inhibitors of proteinases belonging to all four mechanistic classes. Ovomucoid and ovoinhibitor are multidomain Kazal-type inhibitors with each domain containing an actual or putative reactive site for a serine proteinase. Cystatin is a cysteine proteinase inhibitor, while ovostatin inhibits proteinases of all four mechanistic classes. In this review we have summarized the general features, isolation, inhibitory mechanism and evolutionary aspects of these inhibitors.
Saxena
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Department of Biochemistry, Faculty of Medicine, Aligarh Muslim University, India.
Tayyab
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D000818:Animals; D001717:Birds; D002645:Chickens; D004527:Egg Proteins / Q000235:genetics / Q000302:isolation & purification* / Q000378:metabolism; D004529:Egg White; D019143:Evolution, Molecular; D011480:Protease Inhibitors / Q000302:isolation & purification* / Q000378:metabolism
D004527:Egg Proteins; D011480:Protease Inhibitors