title: GM allotypes and IgG subclass concentrations in blacks.
abstract: IgG subclass concentrations were measured in 352 black Americans. Sera were also typed for nine GM allotypes. Serum concentrations of IgG1, IgG3, and IgG4 varied, to different degrees, according to GM phenotypes. The concentration of IgG1 was lower in subjects with GM 1,3,17 5,6,13 compared to those who lacked this phenotype. Elevated levels of IgG3 and IgG4 were associated with GM 1,17 5,6,13 and GM 1,3,17 23 5,13, respectively. Subjects with GM 1,17 5,13,21 had lower levels of IgG3 than individuals with other phenotypes. IgG2 levels were not associated with any of the GM phenotypes. To our knowledge, this represents the first report of an association between GM allotypes and IgG subclasses in blacks.
authors.affiliation: Department of Microbiology and Immunology, Medical University of South Carolina, Charleston 29425-2230, USA. pandeyj@musc.edu
authors.forename: J P
authors.initials: JP
authors.lastname: Pandey
authors.forename: J C
authors.initials: JC
authors.lastname: Gunsolley
authors.forename: J G
authors.initials: JG
authors.lastname: Tew
authors.forename: H A
authors.initials: HA
authors.lastname: Schenkein
mesh_terms: D044383:Black People / Q000235:genetics*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood* / Q000145:classification / Q000235:genetics; D007129:Immunoglobulin Gm Allotypes / Q000097:blood / Q000235:genetics*; D010641:Phenotype; D001741:Black or African American
chemical_list: D007074:Immunoglobulin G; D007129:Immunoglobulin Gm Allotypes