HHV-8 and AIDS-related CNS lymphoma.
Human herpesvirus 8 (HHV-8), the Kaposi's sarcoma (KS)-associated herpesvirus, is closely related to the transforming Epstein-Barr virus (EBV) and may be detected in AIDS-related, EBV-containing, body-cavity-based lymphomas. Accordingly, we analyzed 27 EBV-positive, AIDS-related CNS lymphomas for HHV-8 sequences. Only one tumor yielded HHV-8 sequences; this tumor arose in a patient with concomitant systemic lymphoma and a history of KS. We conclude that HHV-8 is unlikely to have a major role in the pathogenesis of AIDS-related, EBV-associated CNS lymphomas.
Morgello
S
S
Department of Pathology, Mount Sinai Medical Center, New York, NY 10029, USA.
Tagliati
M
M
Ewart
M R
MR
D016543:Central Nervous System Neoplasms / Q000150:complications* / Q000473:pathology / Q000821:virology; D004854:Herpesvirus 4, Human / Q000235:genetics; D019288:Herpesvirus 8, Human / Q000235:genetics; D006801:Humans; D016483:Lymphoma, AIDS-Related / Q000150:complications* / Q000473:pathology / Q000821:virology; D012333:RNA, Messenger / Q000378:metabolism; D012367:RNA, Viral / Q000378:metabolism; D012514:Sarcoma, Kaposi / Q000150:complications* / Q000821:virology
D012333:RNA, Messenger; D012367:RNA, Viral