[Autoantibodies against nerve tissue proteins long after cranio-cerebral injury].
20 samples of serum of patients with remote consequences of brain trauma were tested to detect autoantibodies (a-AB) against brain proteins S-100 and NKP. Essential pathology was not found out by standard solid-phase immunoassay. The original method was used to detect a-AB to the whole complex of antigen determinants. Using this method the elevation of a-AB against S-100 and NKP was shown at 16 cases. The disturbance of idiotype-antiidiotype regulation was revealed at this group of patients. It is suggested that insufficient level of corresponding antiidiotypes creates the conditions for autoimmune aggressor of a-AB against brain tissue.
Morozov
S G
SG
Asanova
L M
LM
Gnedenko
B B
BB
Panchenko
L F
LF
Lavrova
T N
TN
D000328:Adult; D001324:Autoantigens / Q000097:blood*; D001930:Brain Injuries / Q000276:immunology*; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000276:immunology*; D013997:Time Factors
D001324:Autoantigens; D009419:Nerve Tissue Proteins
Autoantitela k belkam nervnoĭ tkani v otdalennom periode cherepno-mozgovoĭ travmy.