Preoperative ECMO in congenital cyanotic heart disease using the AREC system.
BACKGROUND
In cyanotic congenital heart disease, oxygen delivery is impaired either by reduced pulmonary perfusion or by limited entry of oxygenated blood into the systemic circulation. Additional impairment of oxygen delivery (eg, in pulmonary hypertension) leads to hypoxic cerebral damage. Preoperative extracorporeal membrane oxygenation enables oxygenation in otherwise untreatable cases.


METHODS
In 3 neonates suffering from cyanotic congenital heart disease (1 with tricuspid atresia and 2 with transposition of the great arteries) with arterial desaturation despite application of prostaglandins, balloon atrioseptostomy, and eventually inhaled nitric oxide during intermittent positive-pressure ventilation with an inspired oxygen fraction of 1, oxygenation could only be established by means of preoperative extracorporeal membrane oxygenation. We used a venovenous single-lumen cannula tidal-flow extracorporeal membrane oxygenation system described by Chevalier and associates that has previously been used for extracorporeal lung support. In this system, called AREC (assistence respiratoire extra-corporelle), alternating clamps and a nonocclusive roller pump were used.


RESULTS
All 3 survived.


CONCLUSIONS
We conclude that the AREC system enables sufficient preoperative oxygenation in patients with cyanotic congenital heart disease and hypoxia in spite of all conventional therapeutic means. This provides a stable preoperative condition for elective palliation or correction.
Trittenwein
G
G
Department of Neonatology, University Hospital of Vienna, Austria.
Fürst
G
G
Golej
J
J
Frenzel
K
K
Burda
G
G
Hermon
M
M
Marx
M
M
Wollenek
G
G
Pollak
A
A
D003490:Cyanosis; D015199:Extracorporeal Membrane Oxygenation / Q000295:instrumentation*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D010107:Oxygenators, Membrane; D011300:Preoperative Care; D014188:Transposition of Great Vessels / Q000601:surgery*; D018785:Tricuspid Atresia / Q000601:surgery*