title: Correlation of resistance to the alkaloid lycorine with the degree of suppressiveness in petite mutants of Saccharomyces cerevisiae.
abstract: In previous papers (Del Giudice et al. Curr Genet 8:493-497, 1984; Massardo et al. Curr Genet 17:455-457, 1985) we have shown that strains of Saccharomyces cerevisiae that are devoid of mitochondrial DNA (rhoo) are resistant to the alkaloid lycorine isolated from Amaryllis plants, whereas strains containing mitochondrial DNA (rho-, mit-, or rho+) are sensitive to this drug. In addition, we were able to show that the so-called hypersuppressive petites, whose mitochondrial genomes consist of short regions of DNA containing an ori sequence,show intermediate resistance. In this paper, we demonstrate that the degree of suppressiveness of a rho- mutant correlates with the degree of resistance to lycorine.
authors.affiliation: Institut für Biologie IV (Mikrobiologie), Rheinisch-Westfälische Technische Hochschule Aachen, Worringer Weg, D-52056 Aachen, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Del Giudice
authors.forename: D R
authors.initials: DR
authors.lastname: Massardo
authors.forename: F
authors.initials: F
authors.lastname: Manna
authors.forename: N
authors.initials: N
authors.lastname: Koltovaya
authors.forename: H
authors.initials: H
authors.lastname: Hartings
authors.forename: L
authors.initials: L
authors.lastname: Del Giudice
authors.forename: K
authors.initials: K
authors.lastname: Wolf
mesh_terms: D000470:Alkaloids / Q000494:pharmacology*; D047151:Amaryllidaceae Alkaloids; D004272:DNA, Mitochondrial / Q000235:genetics*; D004352:Drug Resistance, Microbial / Q000235:genetics; D009154:Mutation; D010617:Phenanthridines / Q000494:pharmacology*; D012441:Saccharomyces cerevisiae / Q000235:genetics*; D013489:Suppression, Genetic
chemical_list: D000470:Alkaloids; D047151:Amaryllidaceae Alkaloids; D004272:DNA, Mitochondrial; D010617:Phenanthridines; C015330:lycorine