[The participation of the mu-, delta- and kappa-opioid receptors in the realization of the anti-arrhythmia effect of Rhodiola rosea].
A course of the adaptogen extractum Rhodiola rosea (3.5 ml/kg given per os daily for 8 days). produces am antiarrhythmic effect on models of epinephrine-induced arrhythmia. Blockade of mu-opiate receptors (OR) by naloxone (0.2 mg/kg) and delta-OR by ICI 174.864 (2.5 mg/kg) had no effect on the resistance of the heart of rats adapted to epinephrine. Higher doses of naloxone reduced significantly the antiarrhythmic effect of extr. Rhodiola. The antiarrhythmic effect of the extract is assumed to be related to activation of the opioid system and stimulation of kappa-OR.
Maĭmeskulova
L A
LA
Maslov
L N
LN
Lishmanov
Iu B
IuB
Krasnov
E A
EA
D000222:Adaptation, Physiological / Q000187:drug effects; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000188:drug therapy; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004743:Enkephalin, Leucine / Q000031:analogs & derivatives / Q000494:pharmacology; D004837:Epinephrine; D008297:Male; D009270:Naloxone / Q000494:pharmacology; D009292:Narcotic Antagonists / Q000494:pharmacology; D010936:Plant Extracts / Q000627:therapeutic use*; D010946:Plants, Medicinal; D051381:Rats; D011957:Receptors, Opioid / Q000187:drug effects*
D000889:Anti-Arrhythmia Agents; D009292:Narcotic Antagonists; D010936:Plant Extracts; D011957:Receptors, Opioid; D009270:Naloxone; D004743:Enkephalin, Leucine; C040643:N,N-diallyl-tyrosyl-alpha-aminoisobutyric acid-phenylalanyl-leucine; D004837:Epinephrine
Ob uchastii mu-, del'ta- i kappa-opioidnykh retseptorov v realizatsii antiaritmicheskogo éffekta rodioly rozovoĭ.