title: In the mouse, the corticoid stress response depends on lateralization.
abstract: The influence of brain/behavioral lateralization on the neuroendocrine stress response was studied in the mouse. Using a paw preference test in a food reaching task, mice were classified as left-pawed, ambidextrous or right-pawed. Plasma levels of corticosterone (CS) were measured in basal conditions, 4 h after an intraperitoneal injection of lipopolysaccharide (LPS) or after a short period of restraint. In unstressed control mice, plasma levels of corticosterone were higher in left-pawed animals as compared to ambidextrous. LPS increased plasma levels of CS to similarly high levels, around 600 ng/ml, in the three experimental groups. By contrast after 1 h of restraint, the increased CS levels, lower to those observed after LPS injection, were higher in left-pawed mice as compared to right-pawed animals. These results are the first demonstration that activation of the hypothalamic-pituitary-adrenal axis observed during the stress response to a physical stimulus may be related to lateralization.
authors.affiliation: Neurobiologie Intégrative, INSERM Unité 394, Université de Bordeaux II, France.
authors.forename: P J
authors.initials: PJ
authors.lastname: Neveu
authors.forename: S
authors.initials: S
authors.lastname: Moya
mesh_terms: D000818:Animals; D003216:Conditioning, Operant / Q000187:drug effects*; D003345:Corticosterone / Q000097:blood / Q000378:metabolism*; D004926:Escherichia coli; D005260:Female; D005508:Food Deprivation; D007839:Functional Laterality; D008070:Lipopolysaccharides / Q000633:toxicity*; D051379:Mice; D008809:Mice, Inbred C3H; D012149:Restraint, Physical; D013312:Stress, Physiological; D013315:Stress, Psychological
chemical_list: D008070:Lipopolysaccharides; D003345:Corticosterone