Neosartorya fischeri: an invasive fungal pathogen in an allogeneic bone marrow transplant patient.
Invasive fungal infections are a complication of allogeneic BMT. We report the first case of a Neosartorya fischeri fungal infection in a patient following allogeneic BMT. Neosartorya fischeri is related to Aspergillus fumigatus, but it is a distinct fungal species. Despite granulocytic engraftment and aggressive anti-fungal therapy with amphotericin B, the patient died of overwhelming fungal infection on day 60 post-BMT. Neosartorya fischeri is a pathogen that grows slowly in culture which can delay or confuse identification. This case further supports the need for more effective prophylaxis and treatment of non-Candida fungal infections in the allogeneic BMT population.
Lonial
S
S
Department of Medicine, Baylor College of Medicine/Methodist Hospital, Houston, TX, USA.
Williams
L
L
Carrum
G
G
Ostrowski
M
M
McCarthy
P
P
D001232:Aspergillus fumigatus; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D003904:Mitosporic Fungi; D009181:Mycoses / Q000209:etiology*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000628:therapy*; D014184:Transplantation, Homologous