[Presence of autoantibodies in patients infected with HIV].
The presence of serum autoantibodies directed against single-stranded DNA (ssDNA), RNA, histones, nuclear antigen SS-A, mitochondria and cardiolipin were investigated in 30 HIV-negative drug addicts (from years 1986-87), 30 addicts actually infected with HIV and 31 AIDS patients presenting with clinical symptoms indicating autoimmune disorders. Positive results were found in 12 (40%) drug addicts from years 1986-87, 5 (16.7%) actually infected and 16 (51.6%) AIDS patients. Autoantibodies were more often detectable in patients with thrombocytopenia 8/12 (66.7%) than in remaining 8 out of 19 subjects (42.1%) who presented dermatitis, hepatitis, pancarditis, ulcerative colitis and polyneuropathy. The prevalence of autoantibodies in all investigated groups were significantly higher than in controls-1/20 (3.3%).
Radkowski
M
M
Zakład Immunopatologii, Instytut Chorób Zakaznych i Pasozytniczych Akademii Medycznej w Warszawie.
Kopicz-Kamińska
E
E
Werezyńska
T
T
Horban
A
A
Slusarczyk
J
J
D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology*; D000328:Adult; D001323:Autoantibodies / Q000097:blood*; D001324:Autoantigens / Q000276:immunology; D002308:Cardiolipins / Q000276:immunology; D004279:DNA, Viral / Q000276:immunology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008928:Mitochondria / Q000276:immunology; D020733:RNA, Small Cytoplasmic; D012367:RNA, Viral / Q000276:immunology; D012261:Ribonucleoproteins / Q000276:immunology; D000099207:SS-A Antigen
D001323:Autoantibodies; D001324:Autoantigens; D002308:Cardiolipins; D004279:DNA, Viral; D020733:RNA, Small Cytoplasmic; D012367:RNA, Viral; D012261:Ribonucleoproteins; D000099207:SS-A Antigen; C116006:RO60 protein, human
Wystepowanie autoprzeciwciał u osób zakazonych HIV.