title: [Macroprolactinemia, a variety of hyperprolactinemia. Apropos of 5 cases].
abstract: Macroprolactinemia, due to increased circulating levels of large molecular weight forms of prolactin, results in elevated level of immuno-reactive prolactin. The big variants have only weak biological activity; thus macroprolactinemia appears as a case of hyperprolactinemia without clinical significance as demonstrated by the five patients described. The diagnosis is based upon chromatography which separates the hormone and its variants. This disorder produces a pitfall in the diagnostic evaluation of hyperprolactinemia.
authors.affiliation: Service d'endocrinologie, hôpital Pasteur, CHU, Nice, France.
authors.forename: V
authors.initials: V
authors.lastname: Recchi
authors.forename: S
authors.initials: S
authors.lastname: Hieronimus
authors.forename: G
authors.initials: G
authors.lastname: Creisson
authors.forename: P
authors.initials: P
authors.lastname: Freychet
authors.forename: I
authors.initials: I
authors.lastname: Morange
authors.forename: B
authors.initials: B
authors.lastname: Canivet
mesh_terms: D000328:Adult; D002648:Child; D002845:Chromatography; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D006966:Hyperprolactinemia / Q000097:blood / Q000145:classification* / Q000175:diagnosis; D008875:Middle Aged; D008970:Molecular Weight; D011388:Prolactin / Q000737:chemistry*
chemical_list: D011388:Prolactin
vernacular_title: Macroprolactinémie, une variété d'hyperprolactinémie. A propos de cinq observations.