[The physiological characteristics of genetic predisposition to catalepsy in rats depending on the stage of selection].
Male rats with a genetic predisposition to cataleptic reactions revealed a reduced motor activity and a diminished activation of mineralocorticoid and testosterone synthesis in response to a mild stress as compared with the Wistar rats. The reactions, however, were exactly opposite in the Wistar rats with signs of cataleptic features. The data obtained suggest that, when creating genetic animal models of human diseases, the initial stages of breeding should correspond to early stages of the disease whereas advanced stages of breeding are similar to later, chronic phases of the disease.
Shul'ga
V A
VA
Barykina
N N
NN
Alekhina
T A
TA
Kolpakov
V G
VG
D000305:Adrenal Cortex Hormones / Q000097:blood; D000818:Animals; D002375:Catalepsy / Q000097:blood / Q000235:genetics / Q000503:physiopathology*; D004198:Disease Susceptibility; D008297:Male; D009043:Motor Activity / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D017208:Rats, Wistar; D012641:Selection, Genetic; D013315:Stress, Psychological / Q000097:blood / Q000503:physiopathology; D013739:Testosterone / Q000097:blood
D000305:Adrenal Cortex Hormones; D013739:Testosterone
Nekotorye fiziologicheskie kharakteristiki geneticheskoĭ predraspolozhennosti k katalepsii u krys v zavisimosti ot stadii selektsii.