title: Histologic differences in benign prostate hyperplasia between Chinese and American men.
abstract: BACKGROUND
  This investigation sought to determine morphologic differences between Chinese and Americans with symptomatic benign prostatic hyperplasia (BPH), in an admixture of stroma, epithelium, and luminal spaces.
  
  
  METHODS
  Adjacent sections of simple prostatectomy specimens from China and the U.S. were stained to highlight the stroma and epithelium. Image analysis was performed on random fields.
  
  
  RESULTS
  Chinese tissue had higher glandular densities (mean = 12.5 acini/mm2 vs. 6.2 acini/mm2; P < 0.0001), while American samples had higher percent stroma (mean = 66% vs. 51%; P = 0.0003). Mean luminal cell heights in the Chinese and American prostate acini were 11.7 and 19.0 microns, respectively (P < 0.0001).
  
  
  CONCLUSIONS
  These data indicate significant histologic variation in BPH between Chinese and American men undergoing simple prostatectomy. These differences may provide a focus for investigating the epidemiological variation in clinical BPH and carcinoma between our two countries, and could have applications in clinical management of symptomatic BPH.
authors.affiliation: Department of Urology, Affiliated Hospital of Quingdao Medical College, China.
authors.forename: E Y
authors.initials: EY
authors.lastname: Yu
authors.forename: J A
authors.initials: JA
authors.lastname: Siegal
authors.forename: G E
authors.initials: GE
authors.lastname: Meyer
authors.forename: X R
authors.initials: XR
authors.lastname: Ji
authors.forename: X Z
authors.initials: XZ
authors.lastname: Ni
authors.forename: M K
authors.initials: MK
authors.lastname: Brawer
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002681:China; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008875:Middle Aged; D011470:Prostatic Hyperplasia / Q000208:ethnology* / Q000473:pathology*; D014481:United States