[The use of cryopreserved hemopoietic cells of the human embryonic liver in stable depressions of hematopoiesis in cancer patients].
As many as 29 oncological patients with severe depression of hemopoiesis secondary to cytostatic therapy underwent transfusion of fetal liver cells (FLC) from human embryos in the 8-12 weeks stage of their development cryopreserved in 5% DMCO at -196 degrees C as to the method elaborated at the Institute of Problems in Cryobiology and Cryomedicine. A strong correlation was found between infusion of a certain FLC dose and rise in leucocyte counts, which rise occurred by day 13-16 (r = +0.846). A minimum FLC dose for the expected leucocyte count rise to be of the magnitude of 3.32.10(9)/1 appeared to be 10(9) cells. Transplantation had a beneficial effect on the immune status of the patients. There was not a single case of graft-versus-host reaction. The above method has been recommended for use in clinical settings.
Bilyns'kyĭ
B T
BT
Lohins'kyĭ
V O
VO
Savchyk
O B
OB
Oshchebs'kyĭ
O T
OT
D000293:Adolescent; D000328:Adult; D000368:Aged; D015925:Cryopreservation; D005260:Female; D016332:Fetal Tissue Transplantation / Q000009:adverse effects / Q000276:immunology; D006410:Hematopoiesis / Q000276:immunology; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects; D006801:Humans; D007111:Immunity, Cellular; D008099:Liver / Q000196:embryology*; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000097:blood* / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
Zastusovannia kriokonservovanykh hemopoetychnykh klityn embrional'noï pechinky liudyny pry stiĭkykh depresiiakh krovotvorennia u onkolohichnykh khvorykh.