title: High-fat sunflower and olive oil diets affect serum lipid levels in steatotic rat liver differently.
abstract: This work describes the long-term effects of two different diets, one rich in olive oil and the other in sunflower oil, on serum lipid and lipoprotein levels after the establishment of fatty liver in rats 8 and 15 months old. The serum lipid and lipoprotein levels as well as the steatotic process have been evaluated by biochemical and histological methods, respectively. The results showed that fatty liver was well developed with both long-term high-fat diets, and hepatocytes were filled with many lipid droplets. This process was more evident in the portal zones, where fat hepatocytes were more numerous. Serum total cholesterol (TC) and HDL-C levels were highest in the sunflower oil fed rats, whereas the TG and LDL-C levels were highest in the olive oil group. Finally, the atherogenic indexes (HDL/TC, HDL/LDL, HDL/(TC-HDL)) were higher in the sunflower oil diet group than in the olive oil group.
authors.affiliation: Department of Experimental Biology, Faculty of Experimental Sciences, University of Jaén, Spain.
authors.forename: M L
authors.initials: ML
authors.lastname: Del Moral
authors.forename: F J
authors.initials: FJ
authors.lastname: Esteban
authors.forename: M I
authors.initials: MI
authors.lastname: Torres
authors.forename: M V
authors.initials: MV
authors.lastname: Camacho
authors.forename: R
authors.initials: R
authors.lastname: Hernandez
authors.forename: A
authors.initials: A
authors.lastname: Jimenez
authors.forename: A
authors.initials: A
authors.lastname: Aránega
authors.forename: J A
authors.initials: JA
authors.lastname: Pedrosa
authors.forename: M A
authors.initials: MA
authors.lastname: Peinado
mesh_terms: D000818:Animals; D001835:Body Weight; D004032:Diet; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage* / Q000009:adverse effects; D005224:Fats, Unsaturated / Q000737:chemistry; D005234:Fatty Liver / Q000097:blood* / Q000209:etiology; D008055:Lipids / Q000097:blood*; D008074:Lipoproteins / Q000097:blood; D008099:Liver / Q000473:pathology; D008297:Male; D000069463:Olive Oil; D009929:Organ Size; D010938:Plant Oils / Q000008:administration & dosage* / Q000009:adverse effects / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D000074242:Sunflower Oil
chemical_list: D004042:Dietary Fats, Unsaturated; D005224:Fats, Unsaturated; D008055:Lipids; D008074:Lipoproteins; D000069463:Olive Oil; D010938:Plant Oils; D000074242:Sunflower Oil