Zolpidem: distinct from triazolam?
OBJECTIVE
To review the literature that compares zolpidem with triazolam, with an emphasis on efficacy and safety in humans.


METHODS
Information was retrieved from a MEDLINE search (1983-1996) of the English-language literature using the terms triazolam and zolpidem.


METHODS
Reports of clinical trials comparing the safety and efficacy of zolpidem and triazolam were included in this review.


METHODS
Data were evaluated according to study design, efficacy, and adverse effects. Pertinent information was selected and the data synthesized into a review format.


RESULTS
Zolpidem and triazolam have similar pharmacokinetic and pharmacodynamic effects in humans. Clinical trials have shown that usually recommended, equipotent dosages of zolpidem and triazolam do not differ with respect to pharmacokinetics, efficacy, tolerability, residual effects, memory impairment, rebound insomnia, abuse potential, or other adverse effects.


CONCLUSIONS
Zolpidem offers no distinct therapeutic advantage over triazolam for the treatment of insomnia.
Lobo
B L
BL
Department of Pharmacy, Methodist Hospitals of Memphis-Central, TN 38104, USA.
Greene
W L
WL
D006801:Humans; D006993:Hypnotics and Sedatives / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D011725:Pyridines / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D007319:Sleep Initiation and Maintenance Disorders / Q000188:drug therapy* / Q000523:psychology; D014229:Triazolam / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D000077334:Zolpidem
D006993:Hypnotics and Sedatives; D011725:Pyridines; D014229:Triazolam; D000077334:Zolpidem