Heterozygote for plasmin inhibitor deficiency developing hemorrhagic tendency with advancing age.
A heterozygote for congenital deficiency of plasma plasmin in inhibitor had hemorrhagic episodes repeatedly after the age of 79. Before the age of 79, he had not exhibited any hemorrhagic tendency and did not have abnormal bleeding even after surgical operations. Although heterozygotes for congenital deficiency of this inhibitor usually have no or only a mild hemorrhagic tendency, this case suggests that they may exhibit severe hemorrhagic tendency when they reach advanced ages because of age-related vascular changes producing hemostatic imbalance.
Ikematsu
S
S
Department of Clinical Pathology, Tokyo Medical College, Japan.
Fukutake
K
K
Aoki
N
N
D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000097:blood / Q000235:genetics*; D000933:Antifibrinolytic Agents / Q000378:metabolism* / Q000627:therapeutic use; D005342:Fibrinolysis / Q000187:drug effects; D020022:Genetic Predisposition to Disease; D006470:Hemorrhage / Q000097:blood / Q000235:genetics*; D006487:Hemostasis / Q000187:drug effects; D006579:Heterozygote; D006801:Humans; D008297:Male; D010375:Pedigree
D000933:Antifibrinolytic Agents