Spontaneous development of plasmacytomas in a selected subline of BALB/cJ mice.
Sixty per cent of BALB/cAnPt mice injected intraperitoneally (i.p.) with tetramethylpentadecane (pristane) develop plasmacytomas (PCs), whereas less than 10% of BALB/cJ develop such tumours. Most other mouse strains are completely resistant. Resistance is dominant over susceptibility in F1 hybrids between BALB/cAnPt and the resistant non-BALB/c strains, suggesting that susceptibility may be due to some genetic defect. (BALB/cAnPtxBALB/cJ)F1 hybrids have a PC incidence of 36-42%. Previously, BALB/cJ has been shown to harbour at least one resistance gene (Potter et al., Genomics 1988, Vol. 2, pp. 257-262). On the assumption that BALB/cJ may contain a segregating resistance gene, we cross BALB/cJ females with pristane-pretreated BALB/cJ males that were found to be carrying PC cells intraperitoneally 5-7 months after pristane treatment. After two selective crosses, 62% of the BALB/cJ subline BALB/cM2/22 developed PC after pristane and 52% after pristane followed by Abelson virus, while unselected controls had an incidence of 11% and 0%, respectively. Moreover, six spontaneous plasmacytomas developed in untreated females of the selected colony. Five of these carried T(12; 15) (F2; D2/3) translocations. The sixth had a T(1; 10) (G; C1) translocation and an interstitial duplication of segment (C1/E3) on one chromosome 5. It may be concluded that pristane treatment is not a prerequisite for the induction of the PC associated Ig/myc translocations.
Silva
S
S
Microbiology and Tumor Biology Center, Karolinska Institutet, Stockholm, Sweden.
Wang
Y
Y
Babonits
M
M
Imreh
S
S
Wiener
F
F
Klein
G
G
D000818:Animals; D000912:Antibodies, Neoplasm / Q000096:biosynthesis; D015139:Blotting, Southern; D002273:Carcinogens; D002869:Chromosome Aberrations; D004198:Disease Susceptibility; D005260:Female; D016259:Genes, myc; D007074:Immunoglobulin G / Q000096:biosynthesis; D007621:Karyotyping; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010954:Plasmacytoma / Q000139:chemically induced / Q000235:genetics* / Q000276:immunology; D013045:Species Specificity; D013729:Terpenes
D000912:Antibodies, Neoplasm; D002273:Carcinogens; D007074:Immunoglobulin G; D013729:Terpenes; C009042:pristane