title: Massive osteolysis induced by high molecular weight polyethylene wear debris.
abstract: We investigated the mechanism by which particulate wear debris of polyethylene may induce bone resorption using an in vivo model. Two uncemented total hip prostheses, in which the socket was directly in contact with acetabular bone, were selected because there was massive bone loss around the implant. A thick synovium-like layer was found at the polyethylene-bone interface during revision operations. Samples were examined by transmitted and polarised light microscopy, and by transmission electron microscopy. This study demonstrates that polyethylene wear products alone can cause massive osteolysis by triggering the formation of foreign body granuloma at the bone-implant interface.
authors.affiliation: Orthopaedic Department, Catholic University, Rome, Italy.
authors.forename: T
authors.initials: T
authors.lastname: Nizegorodcew
authors.forename: G
authors.initials: G
authors.lastname: Gasparini
authors.forename: G
authors.initials: G
authors.lastname: Maccauro
authors.forename: A
authors.initials: A
authors.lastname: Todesca
authors.forename: E
authors.initials: E
authors.lastname: De Santis
mesh_terms: D005260:Female; D015745:Granuloma, Foreign-Body / Q000209:etiology*; D006621:Hip Joint / Q000000981:diagnostic imaging; D006622:Hip Prosthesis / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D010014:Osteolysis / Q000000981:diagnostic imaging / Q000209:etiology*; D011095:Polyethylenes / Q000009:adverse effects*; D011475:Prosthesis Failure; D011859:Radiography
chemical_list: D011095:Polyethylenes