title: Recognition of osteopontin by rat bone marrow derived osteoblastic primary cells.
abstract: To study the role of osteopontin, we did cell adhesion and ALP assays of rat bone marrow osteoblastic cells (RBMO) on collagen Type I and osteopontin surfaces. The RBMO proved to adhere much more strongly to the osteopontin and to have higher ALP activity on the osteopontin, which suggests that pre-osteoblasts differentiate into osteoblasts that form bone by recognizing osteopontins.
authors.affiliation: Bionic Design Group, National Institute for Advanced Interdisciplinary Research (NAIR), Tsukuba Research Center, Ibaraki, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Yabe
authors.forename: A
authors.initials: A
authors.lastname: Nemoto
authors.forename: T
authors.initials: T
authors.lastname: Uemura
mesh_terms: D000469:Alkaline Phosphatase / Q000378:metabolism; D000595:Amino Acid Sequence; D000818:Animals; D001853:Bone Marrow / Q000201:enzymology; D001854:Bone Marrow Cells; D002448:Cell Adhesion; D002454:Cell Differentiation; D008969:Molecular Sequence Data; D010006:Osteoblasts / Q000166:cytology* / Q000201:enzymology; D053495:Osteopontin; D051381:Rats; D012795:Sialoglycoproteins / Q000502:physiology*
chemical_list: D012795:Sialoglycoproteins; C506897:Spp1 protein, rat; D053495:Osteopontin; D000469:Alkaline Phosphatase