[The role of serum soluble interleukin 2 receptor (sIL-2R) levels in patients with renal cell carcinoma].
OBJECTIVE
The correlation between the serum soluble interleukin-2 receptor (SIL-2R) levels and clinical stage is demonstrable in a variety of non-Hodgkin lymphomas. The prognostic significance of sIL-2R levels in the serum of patients with renal cell carcinoma (RCC) was investigated.


METHODS
sIL-2R were measured in patients with RCC (n=39) and normal control (n=6) by the enzyme immunoassay technique. Cases of RCC were classified according to the clinical stage, pathological grade and growth type. The IL-2R expression of RCC was evaluated by RT-PCR.


RESULTS
The serum sIL-2R levels of patients with RCC showed significantly higher values than those of controls (p < 0.05). The serum sIL-2R levels in RCC were closely associated with the stage, grade and growth type of disease. The patients with high serum sIL-2R level (> = 1,000 U/L) exhibited a significantly poorer prognosis than those with low serum sIL-2R level (<1,000 U/L). The band of IL-R was detected only by using the template from the mRNA extracted from a resected tumor tissue of the RCC but not from the RCC cell lines.


CONCLUSIONS
It was suggested that the measurement of serum sIL-2R levels is useful for predicting the prognosis.
Akiyama
K
K
Department of Urology, School of Medicine, University of Tokushima.
Tsuji
M
M
Kurokawa
Y
Y
Yokota
K
K
Kojima
K
K
Naruo
S
S
Kanayana
H O
HO
Kagawa
S
S
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002292:Carcinoma, Renal Cell / Q000276:immunology* / Q000401:mortality / Q000473:pathology; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000276:immunology* / Q000401:mortality / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D015375:Receptors, Interleukin-2 / Q000097:blood* / Q000502:physiology; D015996:Survival Rate
D015375:Receptors, Interleukin-2