[Complex-formation between myeloperoxidase and fibronectin and its modulation by fibronectin ligands].
Human blood plasma fibronectin immobilised on agarose in physiological interacts with soluble myeloperoxidase (Kd = 2.43 mM). Interaction of myeloperoxidase with fibronectin adsorbed on immobilised gelatin a, natural fibronectin ligand, resulted in formation more stable complex (Kd = 0.94 mM). The presence of thermoaggregated (but not native) IgG in the liquid phase increased a stability of the complex (0.06 mM). It is suggested that myeloperoxidase could represent a component of complex super molecular structure, real immune complex.
Iankovskiĭ
O Iu
OIu
Iablunovskaia
I A
IA
Kokriakov
V N
VN
Aleshina
G M
GM
Khilazhetdinova
L R
LR
Govorova
N Iu
NIu
Podsukhina
G M
GM
Gavrilova
Iu V
IuV
Vakhrushev
A V
AV
Leonova
N V
NV
D005353:Fibronectins / Q000097:blood / Q000737:chemistry*; D006801:Humans; D007074:Immunoglobulin G / Q000737:chemistry; D007700:Kinetics; D008024:Ligands; D046911:Macromolecular Substances; D009195:Peroxidase / Q000097:blood / Q000737:chemistry*
D005353:Fibronectins; D007074:Immunoglobulin G; D008024:Ligands; D046911:Macromolecular Substances; D009195:Peroxidase
Kompleksoobrazovanie mieloperoksidazy i fibronektina i ego moduliatsiia ligandami fibronektina.