title: Modest release of adipsin/factor D by liposuction when using the superwet or tumescent technique.
abstract: Human adipsin is recognized to be identical to factor D, which plays an important role in activation of the alternative complement pathway. Since adipsin/factor D is present in high amounts in adipose tissue, liposuction theoretically could result in an increased release of this serine protease into the bloodstream. In the present study, adipsin/factor D was measured in 22 patients undergoing syringe-assisted liposuction using the superwet or tumescent technique. Despite a relatively high mean aspirate volume (2648 ml), only a very modest increase in adipsin/factor D concentration was found during liposuction. All values before, during, and after liposuction were within the range found in healthy blood donors. Furthermore, there was no correlation between adipsin/factor D values and C3 activation products. We conclude that liposuction with the present techniques results in a very modest release of adipsin/factor D that is not associated with increased complement activation.
authors.affiliation: Department of Plastic Surgery, Trondheim University Hospital, Norway.
authors.forename: F
authors.initials: F
authors.lastname: Samdal
authors.forename: T E
authors.initials: TE
authors.lastname: Mollnes
authors.forename: P F
authors.initials: PF
authors.lastname: Amland
authors.forename: L
authors.initials: L
authors.lastname: Truedsson
mesh_terms: D003167:Complement Activation; D011416:Complement Factor D / Q000378:metabolism*; D006801:Humans; D015187:Lipectomy / Q000379:methods*; D012697:Serine Endopeptidases / Q000378:metabolism*
chemical_list: D012697:Serine Endopeptidases; C493488:CFD protein, human; D011416:Complement Factor D