Neuronal damage and its relation to dementia in acquired immunodeficiency syndrome (AIDS).
There are an estimated 21.8 million people infected with human immunodeficiency virus (HIV) worldwide [Weekly Epidemiol Rec 1996; 27:204-208] and 90% of these people will have some form of neuropathological abnormality during the course of acquired immunodeficiency syndrome (AIDS). In this review, we will highlight the primary HIV-associated brain disorders. The role of HIV proteins and cytokines on neuronal damage will be assessed. We will also discuss the role of neuronal loss and functional damage in HIV-associated dementia.
Trillo-Pazos
G
G
Department of Neuropathology, Institute of Psychiatry, London, UK.
Everall
I P
IP
D015526:AIDS Dementia Complex / Q000209:etiology* / Q000473:pathology* / Q000503:physiopathology; D001921:Brain / Q000503:physiopathology / Q000821:virology; D016207:Cytokines / Q000502:physiology; D006678:HIV / Q000472:pathogenicity / Q000502:physiology; D006801:Humans; D009474:Neurons / Q000473:pathology*; D012191:Retroviridae Proteins / Q000502:physiology
D016207:Cytokines; D012191:Retroviridae Proteins