Application of sperm antigens in immunocontraception.
Development of a vaccine(s) based on sperm antigens represents a promising approach for contraception. The utility of an antigen in immunocontraception is contingent upon its tissue specificity, involvement in human fertility, and immunogenicity. A number of antigens have been characterized from the sperm surface. Notable among these are LDH-C4, RSA antigens, PH-20, SP 1U, HSA-63, FA-1, FA-2 and CS-1. These antigens have been proposed as potential candidates for the development of contraceptive vaccine(s). Their current status, application, relative merits, and immunogenicity in immunocontraception are discussed in this review.
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Division of Research, Department of Obstetrics and Gynecology, Medical College of Ohio, Toledo, Ohio 43699, USA. ddeboe@gemini.mco.edu
D000818:Animals; D000906:Antibodies / Q000276:immunology*; D000941:Antigens / Q000502:physiology*; D003267:Contraception / Q000379:methods*; D005260:Female; D005306:Fertilization; D006801:Humans; D008297:Male; D008322:Mammals; D013094:Spermatozoa / Q000276:immunology*
D000906:Antibodies; D000941:Antigens