title: Evolving concepts of chemical sensitivity.
abstract: Chemical sensitivity appears to be an elusive phenomenon. Studies on individual differences in susceptibility may provide glimpses into the range of sensitivity in a population, which can be used for further study. Preliminary evidence in laboratory animals suggests the range of sensitivity to manufactured chemicals may span orders of magnitude. Determining the reasons that underlie individual differences in sensitivity is a more difficult enterprise. Conditioning of adverse physiological effects of airborne chemicals may play a vital role in the etiology of chemical sensitivity, and it provides a rigorous laboratory model by which to investigate some aspects of this elusive phenomenon.
authors.affiliation: National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA.
authors.forename: R C
authors.initials: RC
authors.lastname: MacPhail
mesh_terms: D000818:Animals; D004361:Drug Tolerance; D004782:Environmental Health; D006801:Humans; D008954:Models, Biological; D018777:Multiple Chemical Sensitivity / Q000209:etiology* / Q000503:physiopathology; D015213:Neuroimmunomodulation