title: Adequate dialysis? Measurement of KT/V in a pediatric peritoneal dialysis population.
abstract: OBJECTIVE
  To measure the urea and creatinine kinetics in a pediatric population.
  
  
  METHODS
  In 19 children treated with peritoneal dialysis (PD) KT/V, urea and creatinine clearances (Ccr) were measured. Thirteen children were on continuous ambulatory peritoneal dialysis (CAPD) and 6 on highly intermittent peritoneal dialysis (NIPD).
  
  
  RESULTS
  Mean KT/V per week was 2.31 +/- 0.78 and mean creatinine clearance 74 +/- 47 L/week/1.73 m2. There was no difference in dialytic KT/V between patients treated with CAPD and NIPD (1.75 +/- 0.21 vs 1.76 +/- 0.50). The correlation between KT/V urea and creatinine clearance was 0.9 (p < 0.001). There was a clear relationship of these parameters with residual renal function, but not with age or blood urea level. A weak positive correlation was found with serum albumin and protein intake.
  
  
  CONCLUSIONS
  Mean KT/V in this patient group was higher than the values reported for most adult patient groups. Residual renal function considerably contributes to this high KT/V. It is not clearly defined which KT/V should be aimed for, since criteria for adequate dialysis are multifactorially determined and therefore difficult to interpret.
authors.affiliation: Department of Pediatrics, University of Nijmegen, The Netherlands.
authors.forename: T L
authors.initials: TL
authors.lastname: Walk
authors.forename: C H
authors.initials: CH
authors.lastname: Schröder
authors.forename: R E
authors.initials: RE
authors.lastname: Reddingius
authors.forename: M
authors.initials: M
authors.lastname: Lelivelt
authors.forename: L A
authors.initials: LA
authors.lastname: Monnens
authors.forename: H L
authors.initials: HL
authors.lastname: Willems
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003404:Creatinine / Q000493:pharmacokinetics*; D006801:Humans; D007223:Infant; D008657:Metabolic Clearance Rate; D010530:Peritoneal Dialysis / Q000379:methods*; D010531:Peritoneal Dialysis, Continuous Ambulatory; D016896:Treatment Outcome; D014508:Urea / Q000493:pharmacokinetics*
chemical_list: D014508:Urea; D003404:Creatinine