Effect of zidovudine on blood composition of the pregnant and fetal baboon.
OBJECTIVE
Our purpose was to assess the effect of intravenous zidovudine on placental function and fetal well-being.


METHODS
Eighteen chronically instrumented third-trimester pregnant baboons and their fetuses were studied after 4- to 48-hour infusions of zidovudine to 14 mothers (0.8 to 2.0 mg/kg/hr) and 6 fetuses (0.2 to 0.22 mg/kg/hr of maternal weight). Fetal and maternal pH and blood gases, hematocrit, blood cell counts, clinical chemistries, electrolytes, and hormones were measured before and after the infusions.


RESULTS
In both mother and fetus no significant differences were found between values in the control periods and those after infusions of zidovudine in any of the index values measured.


CONCLUSIONS
Administration of zidovudine from 4 to 48 hours in the baboon was associated with no significant change in any biochemical index values in the mother or fetus. Thus comparable exposure of the human fetus to zidovudine during labor is not expected to affect these index values of placental function and fetal well-being.
Daniel
S S
SS
Department of Anesthesiology, Columbia College of Physicians and Surgeons, New York, NY 10032, USA.
Garland
M
M
Stark
R I
RI
Myers
M M
MM
Tropper
P J
PJ
D000136:Acid-Base Equilibrium / Q000187:drug effects; D000818:Animals; D003346:Corticotropin-Releasing Hormone / Q000097:blood; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D005333:Fetus / Q000187:drug effects*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D010215:Papio; D010920:Placenta / Q000187:drug effects / Q000502:physiology; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000097:blood*; D015215:Zidovudine / Q000008:administration & dosage / Q000494:pharmacology*
D015215:Zidovudine; D003346:Corticotropin-Releasing Hormone; D006854:Hydrocortisone