title: Changes in hepatic portal resistance and in liver morphology during regeneration: in vitro study in rats.
abstract: OBJECTIVE
  To study the effects of liver regeneration on hepatic portal resistance and on the morphology of liver sinusoids.
  
  
  METHODS
  Experimental in vitro study.
  
  
  METHODS
  University laboratory, Hong Kong.
  
  
  METHODS
  10 Groups of 6 male Sprague Dawley rats each.
  
  
  METHODS
  Two thirds hepatectomy, with subsequent re-hepatectomy for measurements 0, 1, 3, 7, 21 and 56 days later. Perfusion of isolated livers and histomorphometry.
  
  
  METHODS
  Hepatic portal resistance and measurement of width and length of sinusoids.
  
  
  RESULTS
  Liver weight was restored within 7 days of hepatectomy. Hepatic portal resistance/g of liver increased, reaching a maximum at 3 and 7 days of hepatectomy, and subsequently returned to initial values after 56 days. Width of sinusoids decreased to a minimum within 3 to 7 days of hepatectomy, and subsequently returned close to initial values within 56 days of hepatectomy. The changes in hepatic portal resistance occurred in phase with the changes in the width of liver sinusoids.
  
  
  CONCLUSIONS
  There is a transient increase in hepatic portal resistance/g of liver during regeneration; transient narrowing of sinusoids may contribute to this change.
authors.affiliation: Department of Surgery, University of Hong Kong, Queen Mary Hospital, Hong Kong.
authors.forename: P
authors.initials: P
authors.lastname: Gertsch
authors.forename: F
authors.initials: F
authors.lastname: Stipa
authors.forename: J
authors.initials: J
authors.lastname: Ho
authors.forename: S T
authors.initials: ST
authors.lastname: Yuen
authors.forename: I
authors.initials: I
authors.lastname: Luk
authors.forename: I J
authors.initials: IJ
authors.lastname: Lauder
mesh_terms: D000818:Animals; D016001:Confidence Intervals; D004195:Disease Models, Animal; D006498:Hepatectomy; D006499:Hepatic Artery / Q000503:physiopathology*; D008099:Liver / Q000033:anatomy & histology / Q000502:physiology; D008102:Liver Circulation / Q000502:physiology; D008115:Liver Regeneration / Q000502:physiology*; D008297:Male; D010865:Pilot Projects; D017082:Portal Pressure; D011169:Portal Vein / Q000503:physiopathology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012044:Regression Analysis; D014655:Vascular Resistance