title: [The pathogenesis, clinical picture and treatment of poisonings by organic solvents, derivatives of chlorinated hydrocarbons (trichloroethylene, carbon tetrachloride)].
abstract: Clinical studies and experiments on laboratory animals covered mechanism of trichloroethylene toxicity. The chemical and its metabolites cause nonspecific toxic effects in membranes and therefore induce energy metabolism disorder that is proved to be a trigger of pathologic process in the intoxication. Experimental studies failed to disclose and explain mechanism of compromised calcium metabolism and its role in cardiac manifestations seen in trichloroethylene poisoning.
authors.forename: G I
authors.initials: GI
authors.lastname: Sidorin
authors.forename: I M
authors.initials: IM
authors.lastname: Suvorov
authors.forename: L V
authors.initials: LV
authors.lastname: Lukovnikova
mesh_terms: D000062:Accidents, Occupational; D000208:Acute Disease; D000328:Adult; D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007668:Kidney / Q000187:drug effects; D008099:Liver / Q000187:drug effects; D008297:Male; D009784:Occupational Diseases / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy; D011041:Poisoning / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D051381:Rats; D012997:Solvents / Q000506:poisoning* / Q000633:toxicity; D014241:Trichloroethylene / Q000506:poisoning* / Q000633:toxicity
chemical_list: D012997:Solvents; D014241:Trichloroethylene
vernacular_title: Patogenez, klinika i lechenie otravleniĭ nekotorymi organicheskimi rastvoriteliami, proizvodnymi khlorirovannykh uglevodorov (trikhlorétilen, chetyrekhkhloristyĭ uglerod).