Pathogenesis of endometriosis.
This article reviews the pathogenesis of endometriosis, which involves retrograde dissemination of endometrium and/or development in situ by metaplasia, and there is evidence suggesting that genetic and hormonal factors may play a role. There is also substantial evidence that immunologic factors, namely peritoneal macrophages, T cells, natural killer cells, and soluble products secreted by these cells, are involved in the pathogenesis of endometriosis.
Oral
E
E
Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut, USA.
Arici
A
A
D000917:Antibody Formation; D001202:Ascitic Fluid / Q000276:immunology; D004715:Endometriosis / Q000209:etiology* / Q000235:genetics / Q000276:immunology; D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D016023:Integrins / Q000502:physiology; D008598:Menstruation; D012307:Risk Factors
D016023:Integrins