title: [Distal gangrene and cryoglobulinemia related to hepatitis C virus infection with presence of anticardiolipin antibodies].
abstract: We report the case of a 63-year old women with toe gangrene, peripheral polyneuropathy, polyarthritis, histologically proven necrotizing vasculitis, in association with type III mixed cryoglobulinemia and hepatitis C virus (HCV) infection. Raised anticardiolipin antibodies (aCL) were found, without beta 2-glycoprotein I. HCV infection is associated with mixed cryoglobulinemia which can cause a vasculitis affecting various organs. The pathogenesis of production and clinical significance of aCL could be associated in this case with HCV infection.
authors.affiliation: Service de médecine interne, hôpital Broussais, Paris, France.
authors.forename: F
authors.initials: F
authors.lastname: Jacq
authors.forename: J
authors.initials: J
authors.lastname: Emmerich
authors.forename: E
authors.initials: E
authors.lastname: Héron
authors.forename: O
authors.initials: O
authors.lastname: Lortholary
authors.forename: P
authors.initials: P
authors.lastname: Bruneval
authors.forename: J N
authors.initials: JN
authors.lastname: Fiessinger
mesh_terms: D017153:Antibodies, Anticardiolipin / Q000032:analysis*; D003449:Cryoglobulinemia / Q000209:etiology* / Q000628:therapy; D005260:Female; D005734:Gangrene; D006526:Hepatitis C / Q000150:complications* / Q000276:immunology / Q000628:therapy; D006801:Humans; D008875:Middle Aged; D014034:Toes / Q000473:pathology*; D014657:Vasculitis / Q000209:etiology / Q000628:therapy
chemical_list: D017153:Antibodies, Anticardiolipin
vernacular_title: Gangrène distale et cryoglobulinémie liée à l'infection par le virus de l'hépatite C avec présence d'anticorps anticardiolipines.