title: Measurement of flow rates through aortic branches in the anesthetized rabbit.
abstract: The volumetric flow rates, mean and pulsatile, in the aorta and its major branches were measured in nonfed, anesthetized rabbits, using a transit time Doppler ultrasonic flowmeter. Anesthesia was maintained with isoflurane, and a vasodilator was applied topically during the measurements to avoid introducing additional flow resistance due to vasoconstriction. The cranial mesenteric and celiac arteries received the bulk of the aortic flow, (mean +/- SD) 29.5 +/- 6.6% and 23.3 +/- 5.8%, respectively, for mean flow. The brachiocephalic artery received as much as 14.7 +/- 3.2%, while each of the other branches received a considerably smaller fraction: 7.1 +/- 2.5% for the left subclavian artery, 6.2 +/- 2.6% and 5.1 +/- 2.2%, respectively, for the right and left renal arteries, and 6.0 +/- 2.5% for each of the two iliac arteries. Flow divisions were nearly the same in paired vessels. Peak pulsatile flow divisions were similar to their steady flow counterparts in the brachiocephalic, left subclavian, celiac, and cranial mesenteric arteries, but were smaller in the renal and iliac arteries, although the difference was not statistically significant. Reverse flow from one or more of the branches back into the aorta occurred in diastole in seven of eight rabbits studied.
authors.affiliation: Department of Chemical Engineering, Massachusetts Institute of Technology, cambridge, USA.
authors.forename: A I
authors.initials: AI
authors.lastname: Barakat
authors.forename: R P
authors.initials: RP
authors.lastname: Marini
authors.forename: C K
authors.initials: CK
authors.lastname: Colton
mesh_terms: D000758:Anesthesia; D000818:Animals; D001011:Aorta / Q000502:physiology*; D001783:Blood Flow Velocity; D001794:Blood Pressure; D006339:Heart Rate; D007530:Isoflurane; D008297:Male; D011673:Pulsatile Flow; D011817:Rabbits / Q000502:physiology*; D014655:Vascular Resistance; D014661:Vasoconstriction; D014665:Vasodilator Agents / Q000494:pharmacology
chemical_list: D014665:Vasodilator Agents; D007530:Isoflurane