The neuroanatomy of 5-HT dysregulation and panic disorder.
The advent of highly effective antipanic medications with specific serotonin reuptake inhibition as a mechanism of action has prompted the need for new pathophysiological models of panic disorder. The authors attempt an integration of the emerging basic science literature regarding the neuro-anatomy and physiology of the mammalian central serotonin nervous system, its influence on neural substrates that underlie fear and defense responses, and the clinical literature pertaining to serotonin-related abnormalities in panic disorder. A neuro-anatomical model for the potential sites of action of the specific serotonin reuptake inhibitors in panic disorder is proposed.
Grove
G
G
College of Physicians and Surgeons of Columbia University, New York State Psychiatric Institute, NY 10032, USA.
Coplan
J D
JD
Hollander
E
E
D000344:Afferent Pathways / Q000502:physiology; D001306:Auditory Pathways / Q000502:physiology; D001369:Axons / Q000502:physiology; D004525:Efferent Pathways / Q000502:physiology; D006801:Humans; D008125:Locus Coeruleus / Q000502:physiology; D016584:Panic Disorder; D012701:Serotonin / Q000502:physiology*; D014795:Visual Pathways / Q000502:physiology
D012701:Serotonin