title: Interictal cortical excitability to magnetic stimulation in familial hemiplegic migraine.
abstract: We studied interictal cortical excitability with magnetic stimulation in controls, in patients with migraine with aura, and in patients with familial hemiplegic migraine (FHM), in which ictal hemiparesis occurs. Amplitudes (p < 0.05) and amplitude ratios (p < 0.01) revealed heightened excitability in migraine with aura when compared to controls. In patients with FHM, mean thresholds were higher (p < 0.001) and conduction times longer (p < 0.01) than in controls. In FHM, amplitudes were lower on the ictally paretic side of the body than on the other (p < 0.05). Patients with FHM may have increased interictal cortical excitability, complicated by decreased excitability of the affected side.
authors.affiliation: Department of Neurology and Clinical Neurophysiology, Leiden University Hospital, the Netherlands.
authors.forename: W
authors.initials: W
authors.lastname: van der Kamp
authors.forename: A
authors.initials: A
authors.lastname: MaassenVanDenBrink
authors.forename: M D
authors.initials: MD
authors.lastname: Ferrari
authors.forename: J G
authors.initials: JG
authors.lastname: van Dijk
mesh_terms: D000293:Adolescent; D000328:Adult; D002540:Cerebral Cortex / Q000503:physiopathology*; D004056:Differential Threshold; D004558:Electric Stimulation; D005071:Evoked Potentials; D006429:Hemiplegia / Q000235:genetics* / Q000503:physiopathology*; D006801:Humans; D008280:Magnetics; D008875:Middle Aged; D008881:Migraine Disorders / Q000235:genetics* / Q000503:physiopathology*; D009431:Neural Conduction; D013997:Time Factors