title: Exercise training decreases the growth hormone (GH) response to acute constant-load exercise.
abstract: To assess the influence of exercise training on the growth hormone (GH) response to acute exercise, six untrained males completed a 20-min, high-intensity, constant-load exercise test prior to and after 3 and 6 wk of training (the absolute power output (PO) during each test remained constant x PO = 182.5 +/- 29.5 W). Training increased (pre- vs post-training) oxygen uptake (VO2) at lactate threshold (1.57 +/- 0.33 L.min-1 vs 1.97 +/- 0.24 L.min-1 P < or = 0.05). VO2 at 2.5 mM blood lactate concentration ([HLa]) (1.83 +/- 0.38 L.min-1 vs 2.33 +/- 0.38 L.min-1, P < or = 0.05), and VO2peak (3.15 +/- 0.54 L.min-1 vs 3.41 +/- 0.47 L.min-1, P < or = 0.05). Power output at the lactate threshold (PO-LT) increased with training from 103 +/- 28 to 132 +/- 23W (P < or = 0.05). Integrated GH concentration (20 min exercise + 45 min recovery) (microgram.L-1 x min) after 3 wk (138 +/- 106) and 6 wk (130 +/- 145) were significantly lower (P < or = 0.05) than pre-training (238 +/- 145). Plasma epinephrine and norepinephrine responses to training were similar to the GH response (EPI-pre-training = 2447 +/- 1110; week 3 = 1046 +/- 144; week 6 = 955 +/- 322 pmol.L-1; P < or = 0.05; NE pre-training = 23.0 +/- 5.2; week 3 = 13.4 +/- 4.8; week 6 = 12.1 +/- 6.8 nmol.L-1; P < or = 0.05). These data indicate that the GH and catecholamine response to a constant-load exercise stimulus are reduced within the first 3 wk of exercise training and support the hypothesis that a critical threshold of exercise intensity must be reached to stimulate GH release.
authors.affiliation: Department of Human Services, Curry School of Education, Charlottesville, VA, USA.
authors.forename: A
authors.initials: A
authors.lastname: Weltman
authors.forename: J Y
authors.initials: JY
authors.lastname: Weltman
authors.forename: C J
authors.initials: CJ
authors.lastname: Womack
authors.forename: S E
authors.initials: SE
authors.lastname: Davis
authors.forename: J L
authors.initials: JL
authors.lastname: Blumer
authors.forename: G A
authors.initials: GA
authors.lastname: Gaesser
authors.forename: M L
authors.initials: ML
authors.lastname: Hartman
mesh_terms: D000328:Adult; D004837:Epinephrine / Q000097:blood; D015444:Exercise / Q000502:physiology*; D019382:Human Growth Hormone / Q000097:blood / Q000502:physiology*; D006801:Humans; D019344:Lactic Acid / Q000097:blood*; D008297:Male; D009638:Norepinephrine / Q000097:blood; D010101:Oxygen Consumption; D011446:Prospective Studies; D013997:Time Factors
chemical_list: D019382:Human Growth Hormone; D019344:Lactic Acid; D009638:Norepinephrine; D004837:Epinephrine