Effects of histamine agents on methamphetamine-induced stereotyped behavior and behavioral sensitization in rats.
In this study, effects of histamine (HA) agents on methamphetamine (METH)-induced stereotyped behavior and behavioral sensitization were examined in rats. Pretreatment with a precursor of HA, L-histidine (750mg/kg), significantly inhibited the METH (3 mg/kg)-induced stereotyped behavior, whereas pretreatment with an inhibitor of HA synthesis, alpha-fluoromethylhistidine (FMH) (100 mg/kg), an H1 antagonist pyrilamine (5 mg/kg) or an H2 antagonist zolantidine (5 mg/kg) enhanced it. The inhibitory effect of L-histidine on METH-induced stereotyped behavior was significantly blocked by coadministration of pyrilamine and zolantidine, indicating that the effect is mediated through H1 and H2 receptors. Moreover, chronic treatment with METH (3 mg/kg) significantly enhanced stereotyped behavior at the rechallenge with METH (1 mg/kg). Chronic treatment with L-histidine (750 mg/kg) plus METH inhibited the METH-induced argumentation of stereotyped behavior, while that with FMH (100 mg/kg), pyrilamine (5 mg/kg) or zolantidine (5 mg/kg) potentiated it. These findings suggest that the HA neuron system has an inhibitory role in METH-induced stereotyped behavior and behavioral sensitization.
Ito
C
C
Department of Psychiatry, Tohoku University School of Medicine, Aobo-ku, Sendai, Japan.
Onodera
K
K
Watanabe
T
T
Sato
M
M
D000818:Animals; D052160:Benzothiazoles; D001921:Brain / Q000187:drug effects / Q000502:physiology; D000697:Central Nervous System Stimulants / Q000008:administration & dosage; D018494:Histamine Agents / Q000494:pharmacology*; D006639:Histidine / Q000494:pharmacology; D008297:Male; D008694:Methamphetamine / Q000008:administration & dosage; D008762:Methylhistidines / Q000494:pharmacology; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology; D050198:Phenoxypropanolamines; D010880:Piperidines / Q000494:pharmacology; D011738:Pyrilamine / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D011968:Receptors, Histamine / Q000187:drug effects / Q000502:physiology*; D013239:Stereotyped Behavior / Q000187:drug effects* / Q000502:physiology; D013844:Thiazoles / Q000494:pharmacology
D052160:Benzothiazoles; D000697:Central Nervous System Stimulants; D018494:Histamine Agents; D008762:Methylhistidines; D050198:Phenoxypropanolamines; D010880:Piperidines; D011968:Receptors, Histamine; D013844:Thiazoles; D008694:Methamphetamine; D006639:Histidine; C028309:alpha-fluoromethylhistidine; D011738:Pyrilamine; C055302:zolantidine