title: Quality of life in patients with prostatic carcinoma: a review and results of a study in N+ disease. Prostate-specific antigen as predictor of quality of life.
abstract: Clinical evaluation in oncology has typically focused on outcome indicators, while less attention has been paid to how treatment affects quality of life (QOL) of the patient. In this article some general aspects of quality of life are discussed, a short review of published data on QOL in patients with prostate cancer is given and results of a QOL study executed by the authors on patients with lymph node positive prostatic cancer are presented. The purpose of the study was to examine the impact of immediate or delayed treatment (after objective progression) in patients with prostatic carcinoma (T1-3 N1-3 M0) on quality of life parameters. To this end an extended questionnaire was constructed. Fifty-five patients participated. Assessment was performed twice, in 1994 and 1995. The comparison between patients with and patients without treatment showed in 1994 as well as in 1995 significant differences for hormonal treatment side effects such as sexual functioning and hot flushes, all of which were experienced more frequently by treated patients. In 1994 the treated patients experienced more psychological distress while in 1995 they showed worse physical function, less energy and more fatigue when compared to patients under surveillance. The premise that active treatment would improve the psychological quality of life was not sustained. In addition global health status and quality of life were identified as independent factors for progression in untreated patients with lymph node positive prostate cancer. Finally, an increase in prostate-specific antigen (PSA) in hormonally treated patients not only indicated hormonal escape but also a decrease in QOL.
authors.affiliation: Department of Urology, University of Amsterdam, The Netherlands.
authors.forename: G
authors.initials: G
authors.lastname: van Andel
authors.forename: K H
authors.initials: KH
authors.lastname: Kurth
authors.forename: J C
authors.initials: JC
authors.lastname: de Haes
mesh_terms: D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D009376:Neoplasms, Hormone-Dependent / Q000276:immunology / Q000523:psychology / Q000628:therapy; D017430:Prostate-Specific Antigen / Q000097:blood*; D011471:Prostatic Neoplasms / Q000276:immunology* / Q000523:psychology* / Q000628:therapy; D011788:Quality of Life; D011795:Surveys and Questionnaires
chemical_list: D017430:Prostate-Specific Antigen