Increased paternal age in CHARGE association.
The acronym CHARGE refers to a non-random clustering of congenital malformations whose cause remains unknown. Here, we report on a series of 41 patients and find a significant increase in mean paternal age of birth of CHARGE patients (33.7 +/- 8 years) compared with the control population (30.8 +/- 5 years). In contrast, maternal age was not statistically different in patients and controls. These data suggest the possible role of a dominant mutation or, less likely, a subtle chromosomal abnormality in CHARGE association.
Tellier
A L
AL
Service de Génétique Médicale, Hôpital des Enfants Malades, Paris, France.
Lyonnet
S
S
Cormier-Daire
V
V
de Lonlay
P
P
Abadie
V
V
Baumann
C
C
Bonneau
D
D
Labrune
P
P
Lacombe
D
D
Le Merrer
M
M
Nivelon
A
A
Philip
N
N
Briard
M L
ML
Munnich
A
A
D000015:Abnormalities, Multiple / Q000235:genetics*; D000328:Adult; D002648:Child; D002675:Child, Preschool; D003103:Coloboma / Q000235:genetics; D003638:Deafness / Q000235:genetics; D004423:Ear / Q000002:abnormalities; D005260:Female; D005835:Genitalia / Q000002:abnormalities; D006330:Heart Defects, Congenital / Q000235:genetics; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009296:Nasal Cavity / Q000002:abnormalities; D010331:Paternal Age; D013577:Syndrome