A novel human papillomavirus identified in epidermodysplasia verruciformis.
Epidermodysplasia verruciformis (EV) is a rare inherited condition in which there is widespread infection with human papillomavirus (HPV). Patients have a high risk of developing squamous cell carcinoma and Bowen's disease on sun-exposed sites. We describe a Jamaican man with the typical clinical and histopathological features of EV.HPV 8, 24 and a subtype of HPV 38, along with a novel HPV sequence most closely related to HPV 9 have been detected in his skin lesions. Although skin tumours are rare in black patients with EV and he has lived in a temperate climate most of his life, several of the lesions showed bowenoid atypia and he is at risk of developing invasive cutaneous malignancies.
Harris
A J
AJ
Department of Dermatology, Stoke Mandeville Hospital NHS Trust, Aylesbury, U.K.
Purdie
K
K
Leigh
I M
IM
Proby
C
C
Burge
S
S
D004819:Epidermodysplasia Verruciformis / Q000473:pathology / Q000821:virology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D027383:Papillomaviridae / Q000145:classification* / Q000302:isolation & purification; D030361:Papillomavirus Infections / Q000150:complications*; D011230:Precancerous Conditions / Q000821:virology; D012878:Skin Neoplasms / Q000821:virology; D014412:Tumor Virus Infections / Q000150:complications*