Evaluation of the anti-oedematous effects of some H1-receptor antagonists and methysergide in rats.
A combined method was used for a comparative study of some H1 and H2 antagonists and methysergide. In male rats of the Wistar strain weighing 130 +/- 5 g, oedema was induced in the hind paw by the subplantar injection of zymosan, and simultaneously in the ear by the application of croton oil to the inner surface of the ear. Intraperitoneally orally administered H1 antagonists (dimethindene, clemastine, cyproheptadine, astemizole, cetirizine, loratadine and terfenadine) inhibited the oedema to a statistically significant extent, in a dose-dependent manner. Outstanding inhibition was observed after simultaneous administration of the antiserotonin methysergide with dimethindene, clemastine, loratadine or cetirizine.
Blazsó
G
G
Institute of Pharmacodynamics, Albert Szent-Györgyi Medical University, Szeged.
Gábor
M
M
D000818:Animals; D003436:Croton Oil; D004305:Dose-Response Relationship, Drug; D004423:Ear / Q000473:pathology; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control*; D005528:Foot / Q000473:pathology; D006634:Histamine H1 Antagonists / Q000627:therapeutic use*; D008297:Male; D008784:Methysergide / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D012702:Serotonin Antagonists / Q000627:therapeutic use*; D015054:Zymosan
D006634:Histamine H1 Antagonists; D012702:Serotonin Antagonists; D003436:Croton Oil; D015054:Zymosan; D008784:Methysergide