Helicobacter pylori eradication and its implications for the future.
It has become evident that at least some strains of Helicobacter pylori are pathogenic for humans. However, H. pylori are highly diverse and at least part of this variation involves characteristics related to pathogenicity. A large amount of evidence suggests that H. pylori infection of humans is ancient, and in general, the interaction is not terribly destructive. However, we should try to understand better the risks associated with infection with particular H. pylori strains, and limit treatment to those situations in which the indications for eradicating H. pylori are clear-cut. It is entirely possible that some H. pylori strains are commensals, and that others are symbionts. Eradicating those infections could ultimately cause more harm than good. It is too early to reach firm conclusions about whether all H. pylori infections need to be eradicated.
Blaser
M J
MJ
Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232-2605, USA.
D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D005744:Gastric Acid / Q000378:metabolism; D005753:Gastric Mucosa / Q000187:drug effects / Q000473:pathology; D017408:Guidelines as Topic; D016481:Helicobacter Infections / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D016480:Helicobacter pylori / Q000145:classification / Q000187:drug effects* / Q000472:pathogenicity; D006801:Humans; D018442:Lymphoma, B-Cell, Marginal Zone / Q000188:drug therapy / Q000382:microbiology; D010437:Peptic Ulcer / Q000188:drug therapy / Q000382:microbiology; D018570:Risk Assessment; D013274:Stomach Neoplasms / Q000188:drug therapy / Q000382:microbiology
D000900:Anti-Bacterial Agents