title: Causes of death and recurrence after surgery for early gastric cancer.
abstract: The postoperative course of 172 patients with early gastric cancer (EGC) was followed for a median 7 years to evaluate the causes of death, incidence and patterns of recurrence, and characteristic findings in the recurrent cases. The cumulative 10-year mortality rate (+/- SE) was 22 +/- 3.7%. Seven patients (4.1%) died of operative mortality, 11 (6.4%) died of a recurrence of the gastric cancer and 13 (7.6%) died of unrelated causes. Unrelated causes of death were metachronous primary cancer (n = 6), cardiovascular disease (n = 2), pneumonia (n = 3), sepsis (n = 1), and car accident (n = 1). Four patients died from gastric stump recurrence, three from liver metastases, two from lymph node metastases, and two from peritoneal dissemination. Using Cox multivariate analysis, histologic type had the most significant effect on recurrence. Although influenced by the tumor nature, the EGC prognosis is relatively good. Based on the results of this study, particularly in Western institutions, histologic examination of resection margins and lymphadenectomy should be improved. Moreover, patients must be carefully followed for late recurrence and metachronous cancer.
authors.affiliation: Department of Surgery, University of L'Aquila, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Guadagni
authors.forename: M
authors.initials: M
authors.lastname: Catarci
authors.forename: T
authors.initials: T
authors.lastname: Kinoshitá
authors.forename: M
authors.initials: M
authors.lastname: Valenti
authors.forename: G
authors.initials: G
authors.lastname: De Bernardinis
authors.forename: M
authors.initials: M
authors.lastname: Carboni
mesh_terms: D000368:Aged; D002423:Cause of Death; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D005743:Gastrectomy / Q000401:mortality*; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009364:Neoplasm Recurrence, Local / Q000401:mortality; D009367:Neoplasm Staging; D011183:Postoperative Complications / Q000401:mortality*; D011230:Precancerous Conditions / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D013274:Stomach Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D016019:Survival Analysis