Studies on antitussive activity of Drymaria cordata Willd. (Caryophyllaceae).
The methanol extract of Drymaria cordata Willd. was investigated for its effect on a cough model induced by sulfur dioxide gas in mice. It exhibited significant antitussive activity when compared with the control in a dose-dependent manner. The antitussive activity of the extract was comparable to that of codeine phosphate, a prototype antitussive agent. The D. cordata extract (100, 200, 400 mg/kg) showed 11.6%, 31.6% and 51.5% inhibition of cough with respect to the control group.
Mukherjee
P K
PK
Department of Pharmaceutical Technology, Faculty of Engineering and Technology, Jadavpur University, Calcutta, India.
Saha
K
K
Bhattacharya
S
S
Giri
S N
SN
Pal
M
M
Saha
B P
BP
D000818:Animals; D000996:Antitussive Agents / Q000302:isolation & purification / Q000494:pharmacology*; D003061:Codeine / Q000494:pharmacology; D003371:Cough / Q000139:chemically induced / Q000517:prevention & control; D005260:Female; D008297:Male; D000432:Methanol; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D013458:Sulfur Dioxide
D000996:Antitussive Agents; D010936:Plant Extracts; D013458:Sulfur Dioxide; D003061:Codeine; D000432:Methanol