title: Epidemiological characterization of newly recognized rat parvovirus, "rat orphan parvovirus".
abstract: Newly recognized rat parvovirus (rat orphan parvovirus: ROPV) was examined for viral excretion and persistence in infected rats, and also for infectivity to mice and hamsters. The virus appeared to replicate mainly in lymphoid or hematopoietic tissues, and was detected in feces, urine and oropharynx of the infected rats at 1 to 4 weeks postinfection. The infective virus was also detected in peripheral leukocytes and various tissues at an acute phase of infection, and decreased in every tissue at 8 weeks postinfection. Viral DNA, however, was persistent in lymphoid tissues at least up to 24 weeks postinfection. When the virus was inoculated to mice and hamsters, no evidence of viral production and antibody response was demonstrated. ROPV is assumed to be a variant of the known rat parvovirus which resulted to alter cell tropism and persist in lymphoid or hematopoietic tissues, in order to escape from host immune system.
authors.affiliation: Laboratory Animal Research Center, University of Tsukuba, Ibaraki, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Ueno
authors.forename: F
authors.initials: F
authors.lastname: Sugiyama
authors.forename: Y
authors.initials: Y
authors.lastname: Sugiyama
authors.forename: K
authors.initials: K
authors.lastname: Ohsawa
authors.forename: H
authors.initials: H
authors.lastname: Sato
authors.forename: K
authors.initials: K
authors.lastname: Yagami
mesh_terms: D000818:Animals; D000956:Antigens, Viral / Q000032:analysis; D006224:Cricetinae; D004279:DNA, Viral / Q000032:analysis / Q000652:urine; D005243:Feces / Q000737:chemistry; D005260:Female; D006413:Hematopoietic System / Q000737:chemistry / Q000821:virology; D007962:Leukocytes / Q000737:chemistry / Q000821:virology; D008221:Lymphoid Tissue / Q000737:chemistry / Q000821:virology; D008647:Mesocricetus; D051379:Mice; D008813:Mice, Inbred ICR; D010322:Parvoviridae Infections / Q000453:epidemiology / Q000503:physiopathology / Q000662:veterinary*; D017992:Parvovirus / Q000235:genetics; D016133:Polymerase Chain Reaction / Q000662:veterinary; D051381:Rats; D017208:Rats, Wistar; D012376:Rodent Diseases / Q000453:epidemiology* / Q000503:physiopathology / Q000635:transmission; D013047:Specific Pathogen-Free Organisms; D013997:Time Factors; D014779:Virus Replication
chemical_list: D000956:Antigens, Viral; D004279:DNA, Viral