No association between general cognitive ability and the A1 allele of the D2 dopamine receptor gene.
Berman and Noble (1995) reported significantly reduced visuospatial performance in children with the TAQI A1 allele of the D2 dopamine receptor (DRD2) gene. Given that visuospatial performance loads highly on an unrotated principal component indexing general cognitive ability, we tested the association between DRD2 and WISC-R IQ comparing 51 high-IQ, 51 average-IQ, and 35 low-IQ children in the IQ Quantitative Trait Loci (QTL) Project. No statistically significant association between the TAQI A DRD2 alleles and IQ was found. Given that a statistically significant portion of genetic variance for specific cognitive abilities is independent of general cognitive ability, it is possible that the TAQI DRD2 association is specific to visuospatial performance and independent of general cognitive ability.
Petrill
S A
SA
Institute of Psychiatry, London, England. spjwsap@ucl.ac.uk
Plomin
R
R
McClearn
G E
GE
Smith
D L
DL
Vignetti
S
S
Chorney
M J
MJ
Chorney
K
K
Thompson
L A
LA
Detterman
D K
DK
Benbow
C
C
Lubinski
D
D
Daniels
J
J
Owen
M
M
McGuffin
P
P
D000293:Adolescent; D000483:Alleles; D002648:Child; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D006801:Humans; D007360:Intelligence / Q000235:genetics*; D008297:Male; D009949:Orientation; D011597:Psychomotor Performance; D017448:Receptors, Dopamine D2 / Q000235:genetics*
D017448:Receptors, Dopamine D2