title: [Cerebral sinus thrombosis in a patient with protein S deficiency: a case report].
abstract: Cerebral sinus thrombosis associated with protein S deficiency is rare to the best of our knowledge. We report here a 22-year-old female who presented sudden onset of headache, vomiting and disturbance of consciousness. Neuroradiological studies including computed tomography scan, magnetic resonance imaging and cerebral angiography disclosed a huge cerebral sinus thrombosis in the territory of the superior sagittal sinus, torcular herophili, lateral sinus and straight sinus. Hematological studies confirmed the diagnosis of protein S deficiency. We summarize the reported cases of cerebral sinus thrombosis associated with protein S deficiency. For young patients presenting occlusive cerebrovascular disease, we stressed the importance of doing extensive hematological investigation to detect possible etiological factors, such as protein S deficiency, protein C deficiency, antithrombin III deficiency. Once we discover the etiology of a disease, we may be able to designate the precise treatment or regimen for each patient.
authors.affiliation: Department of Neurosurgery, Hyogo Prefectural Awaji Hospital.
authors.forename: A
authors.initials: A
authors.lastname: Fujita
authors.forename: K
authors.initials: K
authors.lastname: Kuwamura
authors.forename: M
authors.initials: M
authors.lastname: Saitoh
authors.forename: Y
authors.initials: Y
authors.lastname: Sakagami
authors.forename: Y
authors.initials: Y
authors.lastname: Takaishi
authors.forename: S
authors.initials: S
authors.lastname: Suzuki
authors.forename: T
authors.initials: T
authors.lastname: Matsuo
authors.forename: N
authors.initials: N
authors.lastname: Tamaki
mesh_terms: D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D018455:Protein S Deficiency / Q000150:complications*; D012851:Sinus Thrombosis, Intracranial / Q000175:diagnosis / Q000209:etiology*; D014057:Tomography, X-Ray Computed