Plasma lipoperoxidative markers in ischaemic stroke suggest brain embolism.
Plasma activity of myeloperoxidase (MPO), malondialdehyde (MDA) and 4-hydroxynonenal (HNE) was measured prior to any treatment in 50 consecutive stroke patients with acute cerebral ischaemia, as well as in 14 healthy control subjects. Mann-Whitney-Wilcoxon test for unpaired data showed greater values of MPO (p < 0.01), MDA (p < 0.01) and HNE (p < 0.05) in stroke patients compared with controls. Considering as covariates the level of consciousness (GCS < 9 vs > or = 9), possible sources of emboli (yes vs no), leukocyte count (< 10 x 10(9)/1 vs > or = 10 x 10(9)/1) and relevant comorbid diseases (yes vs no), exact multiple logistic regression analysis indicated that only the presence of possible cardiac sources of emboli was associated with changes in by-products of lipid peroxidation. If confirmed in a larger series of subjects, our results could have therapeutic implications, providing more support for the use of free radical scavengers in the acute care of stroke patients with a possible cardioembolic aetiology.
Re
G
G
University and S. Orsola-Malpighi Community Teaching Hospital of Bologna, Italy.
Azzimondi
G
G
Lanzarini
C
C
Bassein
L
L
Vaona
I
I
Guarnieri
C
C
D000368:Aged; D000369:Aged, 80 and over; D000447:Aldehydes / Q000097:blood* / Q000378:metabolism; D015415:Biomarkers / Q000097:blood; D002545:Brain Ischemia / Q000150:complications / Q000175:diagnosis* / Q000201:enzymology; D003937:Diagnosis, Differential; D004636:Emergency Service, Hospital; D005260:Female; D006801:Humans; D002542:Intracranial Embolism and Thrombosis / Q000175:diagnosis* / Q000201:enzymology / Q000209:etiology; D016015:Logistic Models; D008297:Male; D008315:Malondialdehyde / Q000097:blood* / Q000378:metabolism; D009195:Peroxidase / Q000097:blood* / Q000378:metabolism; D012680:Sensitivity and Specificity
D000447:Aldehydes; D015415:Biomarkers; D008315:Malondialdehyde; D009195:Peroxidase; C027576:4-hydroxy-2-nonenal