title: Discriminative microcirculatory screening of patients with refractory limb ischaemia for dorsal column stimulation.
abstract: OBJECTIVE
  (1) To determine the proportion of patients with critical limb ischaemia refractory to invasive treatment that can be successfully treated by dorsal column stimulation (DCS), and (2) to identify potential responders to DCS by a simple test that is sufficiently predictive to limit the need for a prolonged trial stimulation period.
  
  
  METHODS
  Twenty patients with chronic limb-threatening ischaemia were assessed by a battery of macro- and microcirculatory tests and a DCS trial of 1 week. Favourable response during the trial determined selection for long-term stimulation.
  
  
  RESULTS
  During a mean observation period of 14 months, limb salvage rate (LSR) was 63% overall and 83% among patients selected after a favourable trial. Of the tests performed preoperatively, digital subtraction angiography, Doppler assessment, oscillometry, capillaroscopy, foot temperature, and transcutaneous partial pressure of oxygen (tcpO2) in the supine or sitting position did not adequately predict DCS response. The supine-sitting tcpO2 gradient (delta tcpO2) was a good predictor of DCS outcome, with an 88% LSR when delta tcpO2 > 15 Torr, dropping to 12% when delta tcpO2 < or = 15 Torr.
  
  
  CONCLUSIONS
  DCS is a rewarding therapeutic option in selected patients with critical limb ischaemia. delta tcpO2 appears to reliably predict response to DCS and may obviate trial stimulation in most cases.
authors.affiliation: Department of Thoracic and Cardiovascular Surgery, University of Bern, Inselspital, Switzerland.
authors.forename: P
authors.initials: P
authors.lastname: Gersbach
authors.forename: M G
authors.initials: MG
authors.lastname: Hasdemir
authors.forename: R D
authors.initials: RD
authors.lastname: Stevens
authors.forename: B
authors.initials: B
authors.lastname: Nachbur
authors.forename: F
authors.initials: F
authors.lastname: Mahler
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015901:Angiography, Digital Subtraction; D001785:Blood Gas Monitoring, Transcutaneous; D001831:Body Temperature; D002908:Chronic Disease; D004599:Electric Stimulation Therapy / Q000295:instrumentation / Q000379:methods; D005069:Evaluation Studies as Topic; D005260:Female; D005500:Follow-Up Studies; D005528:Foot / Q000502:physiology; D005544:Forecasting; D006801:Humans; D007511:Ischemia / Q000175:diagnosis* / Q000628:therapy; D007866:Leg / Q000098:blood supply*; D008297:Male; D008833:Microcirculation; D008875:Middle Aged; D009991:Oscillometry; D018579:Patient Selection; D011187:Posture; D011237:Predictive Value of Tests; D012039:Regional Blood Flow; D015203:Reproducibility of Results; D016683:Supine Position; D013997:Time Factors; D016896:Treatment Outcome; D018608:Ultrasonography, Doppler