Low levels of serum soluble c-kit relates to delayed engraftment after bone marrow transplantation.
Serum soluble c-kit concentrations were measured in 28 patients undergoing bone marrow transplantation (BMT). The c-kit levels in patients with delayed engraftment (time to leukocyte recovery > 1.0 x 10(9)/L being more than 20 days after BMT) were significantly lower than those in patients with early engraftment (time to leukocyte recovery being less than 19 days after BMT) from the start of conditioning until day 100 after BMT. The data from this study indicates that the measurement of serum soluble c-kit concentrations may be a useful indicator of engraftment.
Hashino
S
S
Third Department of Internal Medicine, Hokkaido University School of Medicine, Sapporo, Japan.
Imamura
M
M
Tanaka
J
J
Kobayashi
S
S
Kasai
M
M
Sakurada
K
K
Asaka
M
M
D000293:Adolescent; D000328:Adult; D000972:Antineoplastic Agents, Phytogenic / Q000627:therapeutic use; D016026:Bone Marrow Transplantation; D003520:Cyclophosphamide / Q000627:therapeutic use; D005047:Etoposide / Q000627:therapeutic use; D006084:Graft Rejection; D006086:Graft vs Host Disease / Q000378:metabolism; D006801:Humans; D007938:Leukemia / Q000378:metabolism / Q000628:therapy*; D008223:Lymphoma / Q000378:metabolism / Q000628:therapy*; D019009:Proto-Oncogene Proteins c-kit / Q000097:blood*; D019172:Transplantation Conditioning; D014916:Whole-Body Irradiation
D000972:Antineoplastic Agents, Phytogenic; D005047:Etoposide; D003520:Cyclophosphamide; D019009:Proto-Oncogene Proteins c-kit