Cholesterol homeostasis: clipping out a slippery regulator.
SREBPs are transcriptional activators central to cholesterol homeostasis. Recent work has shown that a two-step cleavage of membrane-bound SREBPs frees them to enter the nucleus. An activator of the first, sterol-regulated proteolysis step has also been identified.
Osborne
T F
TF
Department of Molecular Biology and Biochemistry, University of California, Irvine, California 92697-3900, USA.
D000818:Animals; D022762:CCAAT-Enhancer-Binding Proteins; D016466:CHO Cells; D002467:Cell Nucleus / Q000378:metabolism; D002784:Cholesterol / Q000378:metabolism*; D006224:Cricetinae; D004268:DNA-Binding Proteins / Q000502:physiology*; D010450:Endopeptidases / Q000502:physiology; D053823:Hedgehog Proteins; D006706:Homeostasis; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins / Q000502:physiology*; D009687:Nuclear Proteins / Q000502:physiology*; D011499:Protein Processing, Post-Translational; D011506:Proteins / Q000502:physiology; D051780:Sterol Regulatory Element Binding Protein 1; D051782:Sterol Regulatory Element Binding Protein 2; D013261:Sterols / Q000378:metabolism; D015534:Trans-Activators; D014157:Transcription Factors / Q000502:physiology*; D015533:Transcriptional Activation
D022762:CCAAT-Enhancer-Binding Proteins; D004268:DNA-Binding Proteins; D053823:Hedgehog Proteins; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins; D009687:Nuclear Proteins; D011506:Proteins; C102196:SREBP cleavage-activating protein; D051780:Sterol Regulatory Element Binding Protein 1; D051782:Sterol Regulatory Element Binding Protein 2; D013261:Sterols; D015534:Trans-Activators; D014157:Transcription Factors; D002784:Cholesterol; D010450:Endopeptidases