title: Distribution of HLA-DQA1 alleles in Arab and Pakistani individuals from Dubai, United Arab Emirates.
abstract: PCR-based typing of the HLA-DQA1 locus, using allele specific oligonucleotide (ASO) probes and reverse dot blot methodology was used to determine allelic distributions and construct a database for Arab and Pakistani individuals living in Dubai. Genotype and allelic frequencies were calculated, and the data were tested for departures from Hardy-Weinberg (HWE) equilibrium. The most frequent HLA-DQA1 alleles among Dubaian Arabs are DQA1 4 and 1.2. Among Pakistanis, the most frequent allele is also DQA1 4. No significant deviations from HWE were detected.
authors.affiliation: Indianapolis Marion County Forensic Services Agency, IN 46204, USA.
authors.forename: M A
authors.initials: MA
authors.lastname: Tahir
authors.forename: A Q
authors.initials: AQ
authors.lastname: al Khayat
authors.forename: F
authors.initials: F
authors.lastname: al Shamali
authors.forename: B
authors.initials: B
authors.lastname: Budowle
authors.forename: G E
authors.initials: GE
authors.lastname: Novick
mesh_terms: D000483:Alleles; D018912:Arabs / Q000235:genetics*; D001801:Blood Stains; D004247:DNA / Q000032:analysis*; D005554:Forensic Medicine; D005787:Gene Frequency / Q000235:genetics*; D005819:Genetic Markers; D005838:Genotype; D006683:HLA-DQ Antigens / Q000235:genetics*; D059848:HLA-DQ alpha-Chains; D006801:Humans; D015345:Oligonucleotide Probes / Q000737:chemistry; D010154:Pakistan / Q000208:ethnology; D014479:United Arab Emirates / Q000208:ethnology
chemical_list: D005819:Genetic Markers; D006683:HLA-DQ Antigens; D059848:HLA-DQ alpha-Chains; C069050:HLA-DQA1 antigen; D015345:Oligonucleotide Probes; D004247:DNA