The GCMS analysis of tranylcypromine (Parnate) in a suspected overdose.
A fatal overdose involving tranylcypromine (Parnate) where blood, urine and tissues were quantitated using a pentafluoroproprionic anhydride (PFPA) derivative and gas-chromatography/mass spectroscopy (GCMS). The samples were re-quantified over several weeks demonstrating a significant loss of drug in tissues but not blood or urine specimens. The urine was positive for methamphetamine which has been a suspected metabolite.
Crifasi
J
J
Saint Louis University Medical School, Department of Pathology, Berkeley, Missouri 63134, USA.
Long
C
C
D000328:Adult; D000928:Antidepressive Agents / Q000032:analysis* / Q000506:poisoning*; D001923:Brain Chemistry; D062787:Drug Overdose; D017809:Fatal Outcome; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods; D006801:Humans; D008099:Liver / Q000737:chemistry; D011180:Postmortem Changes; D013997:Time Factors; D014191:Tranylcypromine / Q000032:analysis* / Q000506:poisoning*
D000928:Antidepressive Agents; D014191:Tranylcypromine