1-[3-(Aryloxy) propyl]-diamines: a new class of non-steroidal basic antiinflammatory agents. Structure-activity studies: Part II.
Six substituted aryloxy diamines, synthesized as potential new antiinflammatory agents, were tested in vivo and in vitro in order to evaluate their biological activities. These derivatives reduced significant carrageenin rat paw edema and showed antiproteolytic activity. The in vitro inhibition of soybean lipoxygenase ranged from 41-77%. The results are discussed from the view of structural modifications.
Hadjipavlou-Litina
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Department of Pharmaceutical Chemistry, School of Pharmacy University of Thessaloniki, Greece.
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D000975:Antioxidants / Q000737:chemistry / Q000378:metabolism; D015764:Bepridil / Q000031:analogs & derivatives / Q000737:chemistry / Q000378:metabolism; D001713:Biphenyl Compounds; D003959:Diamines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D004195:Disease Models, Animal; D004487:Edema / Q000188:drug therapy; D005260:Female; D066298:In Vitro Techniques; D016859:Lipoxygenase Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D010851:Picrates; D051381:Rats; D011916:Rats, Inbred F344; D030262:Soybean Proteins / Q000187:drug effects / Q000378:metabolism; D013329:Structure-Activity Relationship
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000975:Antioxidants; D001713:Biphenyl Compounds; D003959:Diamines; D016859:Lipoxygenase Inhibitors; D010851:Picrates; D030262:Soybean Proteins; D015764:Bepridil; C004931:1,1-diphenyl-2-picrylhydrazyl