title: Cartilage viability with interpolated skin flaps: an experimental study.
abstract: Although composite cartilage grafts are often used in conjunction with a midline forehead flap to repair full-thickness nasal defects, the timing of pedicle division, which optimizes cartilage viability, has yet to be determined. A rabbit animal model was designed to investigate this question. The skin flap pedicle was divided at 0 days, 4 days, 3 weeks, 6 weeks, and 10 weeks in each of five groups of five animals. Although early pedicle division led to partial skin flap necrosis, the cartilage grafts tolerated this ischemic period better. Cartilage viability was approximately 70% and did not differ significantly between the five groups. It is concluded that a larger composite graft and better definition of the skin flap's critical period are needed to determine optimum timing for pedicle division in this animal model.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Oregon Health Sciences University, Portland, USA.
authors.forename: S S
authors.initials: SS
authors.lastname: Park
authors.forename: G J
authors.initials: GJ
authors.lastname: White
authors.forename: T A
authors.initials: TA
authors.lastname: Cook
authors.forename: T A
authors.initials: TA
authors.lastname: Wang
authors.forename: S
authors.initials: S
authors.lastname: Kessler
authors.forename: J I
authors.initials: JI
authors.lastname: Cohen
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D002356:Cartilage / Q000098:blood supply / Q000637:transplantation*; D004195:Disease Models, Animal; D004431:Ear, External / Q000601:surgery; D005260:Female; D005546:Forehead / Q000601:surgery; D006085:Graft Survival; D006197:Hair / Q000254:growth & development; D007511:Ischemia / Q000473:pathology; D009296:Nasal Cavity / Q000601:surgery; D009336:Necrosis; D009668:Nose Diseases / Q000601:surgery; D011817:Rabbits; D011897:Random Allocation; D016038:Skin Transplantation / Q000379:methods*; D013997:Time Factors; D014022:Tissue Survival