Attenuated central pressor response to nitric oxide synthesis inhibition in chronic renal failure rats.
OBJECTIVE
Central and peripheral roles of nitric oxide (NO) in blood pressure regulation have been suggested. The present study was aimed at examining if the role of NO in blood pressure regulation is altered in chronic renal failure.


METHODS
Blood pressure responses to acute inhibition of NO were examined in 5/6 nephrectomized rats. Three weeks after the renal ablation, under thiopental (50 mg/kg, i.p.) anesthesia, an intracerebroventricular cannula was placed in the left lateral ventricle and the femoral vein was cannulated to serve as an infusion route. The arterial blood pressure was measured in the right femoral artery. NG-nito-L-arginine methyl ester (L-NAME) was infused (100 microgram/kg per min for 60 min either intracerebroventricularly or intravenously.


RESULTS
Chronic renal failure rats showed a significantly higher arterial pressure than the control rats (147 +/- 14 mmHg vs. 122 +/- 13 mmHg). Intracerebroventricular L-NAME did not affect the arterial pressure in chronic renal failure rats (0.5 +/- 4 mmHg increase from the basal), while it significantly increased the arterial pressure in normal rats (22 +/- 3 mmHg increases from the basal). Intravenous L-NAME increased the arterial pressure, the magnitude of which did not differ between the normal and chronic renal failure rats (24 +/- 3 vs. 16 +/- 3 mmHg increases from the basal).


CONCLUSIONS
These results indicate that the central role of NO in the regulation of blood pressure is altered in chronic renal failure.
Choi
K C
KC
Department of Physiology, Chonnam University Medical School, Kwangju.
Jung
M
M
Lee
J U
JU
Kim
S W
SW
Kim
N H
NH
Kang
Y J
YJ
D000704:Analysis of Variance; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology*; D001795:Blood Pressure Determination; D004195:Disease Models, Animal; D004791:Enzyme Inhibitors / Q000494:pharmacology; D007676:Kidney Failure, Chronic / Q000503:physiopathology*; D008297:Male; D019331:NG-Nitroarginine Methyl Ester / Q000494:pharmacology; D009569:Nitric Oxide / Q000037:antagonists & inhibitors / Q000096:biosynthesis*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012016:Reference Values
D004791:Enzyme Inhibitors; D009569:Nitric Oxide; D019331:NG-Nitroarginine Methyl Ester