[Morpho-immunologic phenotypes of T-cell non-Hodgkin's malignant lymphoma in baboons and their connection with with T-lymphotropic retrovirus STLV-1].
8 cytological types were detected among 58 cases of T-NHL of Papio hamadryas according to human updated Kiel classification (1988). 5 of them were of low grade (lymphocytic, prolymphocytic, T-zone, angioimmunoblastic, small cell pleomorphic) and 3-of high grade (medium and large cell pleomorphic, immunoblastic, large cell anaplastic CD30/Ki-1+). There are differences in a tumor structure and generalization in baboon and human lymphomas in spite of significant similarities. STLV-1 presence (antibodies in blood and virus genome fragments in the lymphoma cell DNA) detected by PCR-amplification in 7 investigated types of baboon T-NHL. CD4+ immune phenotypes were predominant in T-cell baboon lymphomas, while CD8+ phenotypes were rare. Abnormal phenotypes in some cases were also detected in the three-color FACS-analyses.
Iakovleva
L A
LA
Max von Pettenkofer Institute, Munchen, Germany.
Indzhiia
L V
LV
Chikobaeva
M G
MG
Shatsl'
G
G
Lapin
B A
BA
D000818:Animals; D016516:CD4-CD8 Ratio; D006801:Humans; D016130:Immunophenotyping; D008208:Lymphatic System / Q000276:immunology / Q000473:pathology; D016399:Lymphoma, T-Cell / Q000276:immunology / Q000473:pathology* / Q000821:virology; D010215:Papio; D016133:Polymerase Chain Reaction; D015303:Simian T-lymphotropic virus 1 / Q000502:physiology*
Morfoimmunologicheskie fenotipy T-kletochnykh nekhodzhinskikh zlokachestvennykh limfom pavianov i ikh sviaz' s T-limfotropnym retrovirusom STLV-1.