Evaluation of himachalol in murine invasive aspergillosis.
Himachalol (a sesquiterpene alcohol) showed low in vitro minimum inhibitory concentrations against Aspergillus fumigatus by the macro- and microbroth dilution techniques (genometric mean 250 micrograms ml-1 and 46.4 micrograms ml-1 respectively) compared with saperconazole. Swiss mice treated with the phytoproduct (200 mg kg-1, p.o.) once daily for 7 days exhibited a significant (P < 0.001) protection (60%) together with an increase in the mean survival time (15 days) and a reduced CFU (mean log10) burden of A. fumigatus in the kidneys.
Chowdhry
L
L
Division of Medical Mycology, Central Drug Research Institute, Lucknow, India.
Khan
Z K
ZK
Kulshrestha
D K
DK
D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001228:Aspergillosis / Q000188:drug therapy*; D001232:Aspergillus fumigatus / Q000187:drug effects / Q000302:isolation & purification; D001393:Azoles / Q000494:pharmacology; D001567:Benzocycloheptenes / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D051379:Mice; D008826:Microbial Sensitivity Tests; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes / Q000494:pharmacology / Q000627:therapeutic use*
D000935:Antifungal Agents; D001393:Azoles; D001567:Benzocycloheptenes; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes; C010185:himachalol; C060571:saperconazole