title: [Low-risk thyroid carcinoma--therapy, follow-up and prognosis].
abstract: OBJECTIVE
  A retrospective study was performed to determine the frequency of local recurrences and distant metastases as well as potential risk factors in patients with low-risk differentiated thyroid carcinoma. In addition, the efficiency of our follow-up programme and the diagnostic value of the procedures administered was to be evaluated.
  
  
  RESULTS
  41/740 (8%) patients developed 62 recurrences at a mean 4.7 years after the onset of the disease. In 14 cases the tumor marker thyroglobulin was the first diagnostic sign. 13 recurrences were diagnosed by chest x-ray and/or CT. In 12 cases recurrences/metastases were detected by iodine-131 whole body scan, and 8 cases by ultrasound of the neck. A good prognosis was found if patients were under 45 years of age when the tumor was first diagnosed, and if the tumor did not exceed 20 mm in diameter. The prognosis was not statistically significant influenced by histology, gender and surgical methods. The 10-year survival rate for papillary carcinomas was 91% and for follicular carcinomas 84%.
  
  
  CONCLUSIONS
  We recommend yearly follow-up examinations with selective use of other diagnostic methods in order to provide best patient care.
authors.affiliation: Abteilung Nuklearmedizin und spezielle Biophysik, Medizinischen Hochschule Hannover, Deutschland.
authors.forename: S
authors.initials: S
authors.lastname: Sophocleous
authors.forename: C
authors.initials: C
authors.lastname: Ehrenheim
authors.forename: J
authors.initials: J
authors.lastname: Fischer
authors.forename: H
authors.initials: H
authors.lastname: Hundeshagen
mesh_terms: D000328:Adult; D000367:Age Factors; D002277:Carcinoma / Q000453:epidemiology / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006258:Head and Neck Neoplasms / Q000453:epidemiology / Q000401:mortality / Q000556:secondary; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology; D011379:Prognosis; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D013964:Thyroid Neoplasms / Q000453:epidemiology / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D013965:Thyroidectomy; D013997:Time Factors
chemical_list: D007457:Iodine Radioisotopes
vernacular_title: Das Low-risk-Schilddrüsenkarzinom--Therapie, Nachsorge und Prognose.