[Sensitization to industrial chemical allergens in bronchial asthma in children in environmental pollution].
Examination covered 41 children with bronchial asthma varying in severity, who live in ecologically hazardous industrial area. High incidence of sensibilization to industrial chemical allergens (chromium, nickel, formaldehyde and sometimes manganese and beryllium) appeared to be a feature of the examinees. Effect of IgE binding, a specific in vitro provocation test, identified pathogenic role of sensibilization to industrial allergens polluting environment. Clinical and immunologic principles revealed are basis for safe, specific and informative laboratory methods diagnosing sensibilization to industrial chemical allergens in ecologic, epidemiologic and clinical pediatric investigation.
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D000293:Adolescent; D000367:Age Factors; D000393:Air Pollutants / Q000276:immunology*; D000485:Allergens; D001249:Asthma / Q000139:chemically induced / Q000276:immunology*; D001608:Beryllium / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D002857:Chromium / Q000276:immunology; D005260:Female; D005557:Formaldehyde / Q000276:immunology; D006801:Humans; D007124:Immunoenzyme Techniques; D007073:Immunoglobulin E / Q000032:analysis; D008297:Male; D008345:Manganese / Q000276:immunology; D009532:Nickel / Q000276:immunology
D000393:Air Pollutants; D000485:Allergens; D002857:Chromium; D005557:Formaldehyde; D007073:Immunoglobulin E; D008345:Manganese; D009532:Nickel; D001608:Beryllium
Sensibilizatsiia k promyshlennym khimicheskim allergenam pri bronkhial'noĭ astme u deteĭ v usloviiakh zagriazneniia okruzhaiushcheĭ sredy.