title: The Escherichia coli phage-shock-protein (psp) operon.
abstract: The phage-shock-protein (psp) operon helps to ensure survival of Escherichia coli in late stationary phase at alkaline pH, and protects the cell against dissipation of its proton-motive force against challenge. It is strongly induced by filamentous phage pIV and its bacterial homologues, and by mutant porins that don't localize properly, as well as by a number of other stresses. Transcription of the operon is dependent on sigma54 and a constitutively active, autogenously controlled activator. psp-operon expression is controlled by one negatively and several positively acting regulators, none of which is a DNA-binding protein. The major product of the operon, PspA, may also serve as a negative regulator of an unusual porin, OmpG.
authors.affiliation: The Rockefeller University, New York, New York 10021, USA. model@rockvax.rockefeller.edu
authors.forename: P
authors.initials: P
authors.lastname: Model
authors.forename: G
authors.initials: G
authors.lastname: Jovanovic
authors.forename: J
authors.initials: J
authors.lastname: Dworkin
mesh_terms: D004926:Escherichia coli / Q000235:genetics* / Q000378:metabolism; D015870:Gene Expression; D014644:Genetic Variation; D006360:Heat-Shock Proteins / Q000235:genetics* / Q000502:physiology*; D005810:Multigene Family; D009876:Operon
chemical_list: D006360:Heat-Shock Proteins