title: Tumor size and axillary metastasis, a correlative occurrence in 1244 cases of breast cancer between 1980 and 1995.
abstract: A review of 1244 breast cancer cases from the Tumor Registry of Northwest Community Hospital between 1980 and 1995 was carried out to investigate the incidence of axillary metastasis. There were 442 patients (35.45%) with positive nodes. The small lesions were graded to ascertain if size and grade of small tumors can be used to predict axillary metastasis. One hundred and seventy-nine cases of < or = 1.0 cm were retrospectively reviewed by one pathologist. Tumors <0.4 cm had negative nodes. Those with nuclear and histologic grades of 1 had 3% positive nodes, the remainder had positive nodes ranging from 11% to 19%. Infiltrating duct cancers of nuclear grade 3, histologic grade 2, and positive nodes, showed a 40% mortality. Eighteen patients died in the 0.5-1.0 cm tumor size range, mostly of histologic grade 2 and nuclear grade 3. Nuclear and histologic grade 1 tumors with infiltrating duct cancers had negative nodes and showed a good prognosis. Based on this study, node dissection can be omitted in these patients and in those with tumors < or = 0.4 cm. For all other lesions, full axillary node dissection and detailed pathologic examination is still the gold standard for evaluating the axilla.
authors.affiliation: Department of Medical Oncology, Northwest Community Hospital, Arlington Heights, IL 60005, USA.
authors.forename: M R
authors.initials: MR
authors.lastname: Shetty
authors.forename: H M
authors.initials: HM
authors.lastname: Reiman
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology / Q000556:secondary / Q000601:surgery; D001365:Axilla; D001943:Breast Neoplasms / Q000473:pathology* / Q000601:surgery; D002277:Carcinoma / Q000473:pathology / Q000556:secondary / Q000601:surgery; D002278:Carcinoma in Situ / Q000473:pathology / Q000556:secondary / Q000601:surgery; D018270:Carcinoma, Ductal, Breast / Q000473:pathology / Q000556:secondary* / Q000601:surgery; D002423:Cause of Death; D005260:Female; D005544:Forecasting; D006764:Hospitals, Community; D006801:Humans; D015994:Incidence; D008197:Lymph Node Excision; D008207:Lymphatic Metastasis / Q000473:pathology*; D015411:Mastectomy, Modified Radical; D015412:Mastectomy, Segmental; D009361:Neoplasm Invasiveness; D011379:Prognosis; D012042:Registries; D012189:Retrospective Studies; D015996:Survival Rate