Desmopressin tablet treatment: factors influencing gastrointestinal absorption.
The effect of food ingestion on the gastrointestinal absorption and antidiuretic action of oral desmopressin (Minirin, DDAVP) was assessed in 16 healthy volunteers, aged 20-35 years. The gastrointestinal absorption of desmopressin was reduced and delayed if administered with or 90 minutes after a meal, but this did not influence the antidiuretic action of the drug, at least for the first 3 hours following desmopressin administration.
Rittig
S
S
Research Laboratory of Nephrology and Hypertension, Skejby Hospital, University Hospital of Aarhus, Denmark.
Jensen
A R
AR
Jensen
K T
KT
Pedersen
E B
EB
D000042:Absorption; D000284:Administration, Oral; D000328:Adult; D001682:Biological Availability; D018592:Cross-Over Studies; D003894:Deamino Arginine Vasopressin / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D004064:Digestive System / Q000187:drug effects / Q000378:metabolism*; D004435:Eating; D006801:Humans; D008297:Male; D009994:Osmolar Concentration; D012016:Reference Values; D012076:Renal Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D014556:Urine / Q000737:chemistry
D012076:Renal Agents; D003894:Deamino Arginine Vasopressin