A gene for autosomal dominant nonsyndromic hearing loss (DFNA12) maps to chromosome 11q22-24.
We performed linkage analysis in a Belgian family with autosomal dominant midfrequency hearing loss, which has a prelingual onset and a nonprogressive course in most patients. We found LOD scores >6 with markers on chromosome 11q. Analysis of key recombinants maps this deafness gene (DFNA12) to a 36-cM interval on chromosome 11q22-24, between markers D11S4120 and D11S912. The critical regions for the recessive deafness locus DFNB2 and the dominant locus DFNA11, which were previously localized to the long arm of chromosome 11, do not overlap with the candidate interval of DFNA12.
Verhoeven
K
K
Department of Medical Genetics, University of Antwerp, Belgium.
Van Camp
G
G
Govaerts
P J
PJ
Balemans
W
W
Schatteman
I
I
Verstreken
M
M
Van Laer
L
L
Smith
R J
RJ
Brown
M R
MR
Van de Heyning
P H
PH
Somers
T
T
Offeciers
F E
FE
Willems
P J
PJ
D001301:Audiometry, Pure-Tone; D001530:Belgium; D002874:Chromosome Mapping; D002880:Chromosomes, Human, Pair 11; D005260:Female; D005799:Genes, Dominant; D005819:Genetic Markers; D006312:Hearing Loss, Bilateral / Q000175:diagnosis / Q000235:genetics*; D006801:Humans; D008126:Lod Score; D008297:Male; D010375:Pedigree
D005819:Genetic Markers