Prevention of ACTH- and adrenalectomy-induced muricidal behavior: by benzodiazepinic ligands.
We investigated the effect of treatment with central (neuronal and glial) benzodiazepine binding site-active molecules on ACTH- or adrenalectomy (ADX)-induced muricidal behavior in male Wistar rats. Pretreatment (IP) with either flumazenil or clonazepam prevented the subsequent induction of ADX-induced behavior, but only flumazenil protected against ACTH-induced behavior; posttreatment in both cases induced no significant modifications. Using 4'-chloro-diazepam or PK 11195, both pre- and posttreatment afforded protection, the effect lasting longer (> 1 week) than that induced by flumazenil or clonazepam (2 days). Pretreatment with the GABAA agonist, muscimol, also resulted in complete protection, whereas posttreatment had only a slight effect.
Miachon
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INSERM U52 CNRS ERS 5645, Faculte de Medecine Grange Blanche, Lyon, France.
Cespuglio
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D000315:Adrenalectomy; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology*; D000374:Aggression / Q000187:drug effects / Q000502:physiology*; D000818:Animals; D001570:Benzodiazepinones / Q000494:pharmacology; D002998:Clonazepam / Q000494:pharmacology*; D005442:Flumazenil / Q000494:pharmacology*; D018757:GABA Modulators / Q000494:pharmacology; D007546:Isoquinolines / Q000494:pharmacology; D008297:Male; D051379:Mice; D009118:Muscimol / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D011963:Receptors, GABA-A / Q000502:physiology; D013997:Time Factors
D001570:Benzodiazepinones; D018757:GABA Modulators; D007546:Isoquinolines; D011963:Receptors, GABA-A; D009118:Muscimol; C028513:4'-chlorodiazepam; D005442:Flumazenil; D002998:Clonazepam; D000324:Adrenocorticotropic Hormone; C037850:PK 11195