Serum levels of soluble intercellular adhesion molecule-1 (ICAM-1) and the expression of ICAM-1 mRNA in uterine cervical cancer.
The purpose of this investigation was to evaluate the serum level of soluble intercellular adhesion molecule-1 (sICAM-1) in patients with squamous cell carcinoma of the cervix. Serum levels of sICAM-1 were measured by enzyme-linked immunosorbent assay in patients with cervical cancer (stage 0 through IV). Expression of mRNA in tumor tissues was evaluated by reverse transcriptase-polymerase chain reaction. Serum level of sICAM-1 in patients with advanced-stage (II-IV) or recurrent cervical cancer was found to be increased significantly. Expression of ICAM-1 mRNA was observed in most tumor tissues. Results suggest that sICAM-1 is shed from the cancerous tissue in patients with squamous cell carcinoma of the cervix.
Nasu
K
K
Department of Obstetrics and Gynecology, Oita Medical University, Hasama-machi, Japan.
Narahara
H
H
Etoh
Y
Y
Kawano
Y
Y
Hirota
Y
Y
Miyakawa
I
I
D002294:Carcinoma, Squamous Cell / Q000097:blood / Q000378:metabolism*; D005260:Female; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000096:biosynthesis* / Q000097:blood* / Q000235:genetics; D009364:Neoplasm Recurrence, Local / Q000097:blood / Q000378:metabolism; D012333:RNA, Messenger / Q000096:biosynthesis; D002583:Uterine Cervical Neoplasms / Q000097:blood / Q000378:metabolism*
D012333:RNA, Messenger; D018799:Intercellular Adhesion Molecule-1