title: alpha2,3-sialyltransferase mRNA and alpha2,3-linked glycoprotein sialylation are increased in malignant gliomas.
abstract: CMP-NeuAc: Galbeta1,3(4)GlcNAc alpha2,3-sialyltransferase (alpha2,3-ST) mRNA was expressed in human glioma specimens, human fetal astrocytes, and a panel of brain tumor cell lines. Maackia amurensis agglutinin staining revealed the presence of alpha2,3-linked sialic acids on glioma cell surfaces and extracellular matrices whereas normal human adult astrocytes were negative. Increased expression of alpha2,3-linked glycoprotein sialylation may play a role in glial tumorigenesis.
authors.affiliation: The Chicago Institute of Neurosurgery and Neuroresearch, IL 60614, USA.
authors.forename: H
authors.initials: H
authors.lastname: Yamamoto
authors.forename: T
authors.initials: T
authors.lastname: Saito
authors.forename: Y
authors.initials: Y
authors.lastname: Kaneko
authors.forename: D
authors.initials: D
authors.lastname: Kersey
authors.forename: V W
authors.initials: VW
authors.lastname: Yong
authors.forename: E G
authors.initials: EG
authors.lastname: Bremer
authors.forename: E
authors.initials: E
authors.lastname: Mkrdichian
authors.forename: L
authors.initials: L
authors.lastname: Cerullo
authors.forename: J
authors.initials: J
authors.lastname: Leestma
authors.forename: J R
authors.initials: JR
authors.lastname: Moskal
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism; D001253:Astrocytes / Q000378:metabolism; D001254:Astrocytoma / Q000378:metabolism; D001932:Brain Neoplasms / Q000378:metabolism* / Q000556:secondary; D002236:Carbohydrate Conformation; D005909:Glioblastoma / Q000378:metabolism; D005910:Glioma / Q000378:metabolism*; D006023:Glycoproteins / Q000378:metabolism*; D006801:Humans; D012333:RNA, Messenger / Q000378:metabolism*; D012799:Sialyltransferases / Q000235:genetics*; D014407:Tumor Cells, Cultured; D000094663:beta-Galactoside alpha-2,3-Sialyltransferase
chemical_list: D006023:Glycoproteins; D012333:RNA, Messenger; D012799:Sialyltransferases; D000094663:beta-Galactoside alpha-2,3-Sialyltransferase; C000722087:ST3GAL1 protein, human