title: Asthma: early predisposing factors.
abstract: The significance of factors affecting the development of asthma and atopy in children must be judged against their ability to contribute to the increase in childhood asthma. Although genetic factors are clearly important to the development of asthma and atopy, they can not explain the increased prevalence of these conditions.
authors.affiliation: Paediatric Intensive Care Unit, Hospital for Sick Children, London, UK.
authors.forename: I J
authors.initials: IJ
authors.lastname: Doull
authors.forename: S T
authors.initials: ST
authors.lastname: Holgate
mesh_terms: D001249:Asthma / Q000453:epidemiology / Q000209:etiology* / Q000235:genetics; D002648:Child; D002869:Chromosome Aberrations; D025063:Chromosome Disorders; D002880:Chromosomes, Human, Pair 11; D002883:Chromosomes, Human, Pair 14; D002895:Chromosomes, Human, Pair 5; D002896:Chromosomes, Human, Pair 6; D004198:Disease Susceptibility; D004200:Diseases in Twins; D005260:Female; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000453:epidemiology / Q000209:etiology* / Q000235:genetics; D008297:Male; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D015995:Prevalence; D012907:Smoking; D014777:Virus Diseases / Q000150:complications