title: Increased prevalence of large bites in 12-lead vectorcardiograms of diabetic patients.
abstract: The vectorcardiographic (VCG) bites in diabetic patients were compared with those in nondiabetic control subjects using automated analysis of the conventional electrocardiogram (ECG). A 12-lead ECG was recorded from each of the 154 patients with non-insulin-dependent diabetes mellitus and 128 control subjects. The orthogonal leads X, Y, and Z were derived from the 12-lead ECG, from which a so-called 12-lead VCG was calculated for each of the 282 participants. A computer-based method for the detection and quantification of bites was applied to the 12-lead VCGs. Bite amplitudes in the horizontal loop had an average of 0.062 +/- 0.089 mV in the diabetic group, and 0.039 +/- 0.045 mV in the control group (P < .01). In the sagittal plane, the mean bite amplitude was also greater in the diabetic group than in the control group: 0.095 +/- 0.084 versus 0.069 +/- 0.058 mV, respectively (P < .01). A bite greater than 0.1 mV in the horizontal or sagittal planes was found in 56 diabetic patients (36%) and 27 control subjects (21%) with (P < .05) considered significant. In conclusion, the results of this study suggest that automated analysis of the 12-lead VCG can be valuable in diagnosing diabetic cardiomyopathy.
authors.affiliation: Department of Clinical Physiology, Lund University Hospital, Sweden.
authors.forename: L
authors.initials: L
authors.lastname: Edenbrandt
authors.forename: A
authors.initials: A
authors.lastname: Jakobsson
authors.forename: E
authors.initials: E
authors.lastname: Lindvall
authors.forename: P O
authors.initials: PO
authors.lastname: Bitzén
authors.forename: O
authors.initials: O
authors.lastname: Pahlm
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D009202:Cardiomyopathies / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000503:physiopathology*; D003936:Diagnosis, Computer-Assisted; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012815:Signal Processing, Computer-Assisted; D014672:Vectorcardiography / Q000379:methods*