title: Genetics of renal tumours.
abstract: The two main renal tumours, Wilms' tumour and renal cell carcinoma, are associated with distinct molecular genetic abnormalities. The genes involved behave as Knudson oncosuppressor genes. Further dissection of the molecular biology pathways involving WT1 and VHL genes is providing fascinating insight into the biology of these genes, the development and cell biology of the kidney and its tumours.
authors.affiliation: Department of Pathology, University of Edinburgh, UK.
authors.forename: S
authors.initials: S
authors.lastname: Fleming
mesh_terms: D001506:Beckwith-Wiedemann Syndrome / Q000235:genetics; D002292:Carcinoma, Renal Cell / Q000235:genetics*; D002874:Chromosome Mapping; D004268:DNA-Binding Proteins / Q000235:genetics; D004198:Disease Susceptibility; D016147:Genes, Tumor Suppressor; D016158:Genes, p53; D018392:Genomic Imprinting; D006801:Humans; D007680:Kidney Neoplasms / Q000235:genetics*; D008025:Ligases; D011506:Proteins / Q000235:genetics; D014157:Transcription Factors / Q000235:genetics; D025521:Tumor Suppressor Proteins; D044767:Ubiquitin-Protein Ligases; D051794:Von Hippel-Lindau Tumor Suppressor Protein; D025721:WT1 Proteins; D009396:Wilms Tumor / Q000235:genetics*; D006623:von Hippel-Lindau Disease / Q000235:genetics
chemical_list: D004268:DNA-Binding Proteins; D011506:Proteins; D014157:Transcription Factors; D025521:Tumor Suppressor Proteins; D025721:WT1 Proteins; D044767:Ubiquitin-Protein Ligases; D051794:Von Hippel-Lindau Tumor Suppressor Protein; D008025:Ligases; C497446:VHL protein, human