[The clinico-immunological characteristics of the treatment of patients with a severe course of bronchial asthma using the method of the extracorporeal incorporation of pig donor spleen].
A comprehensive clinical-and-immunological evaluation was done of efficiency of treatment of patients with severe forms of bronchial asthma (BA) by hemosorption through donor porcine spleen, xenosorption (XS), in 63 patients. XS was found out to have a marked positive clinical effect manifested by a considerable decrease of frequency of asphyxiation bouts and amounts of inhalation broncholytics being taken within the first 24 hours after the procedure. By day 14 from the start of XS we succeeded in lowering the systemic corticosteroids maintenance dose on the average 2.5 times as little. Positive clinical dynamics correlated with positive immunologic changes which revealed themselves in normalization of numbers as well as functional activity of T-cells, rise in T-helpers, normalization of content of serum immunoglobulins A, M and G, with the parameters characterizing the system of phagocytosis approaching the norm, the processes of autoimmunization getting more attenuated.
Kovalenko
N N
NN
Tkachenko
Iu Ia
IuIa
Kogosova
L S
LS
Kruglova
I F
IF
Panashchuk
I A
IA
D000208:Acute Disease; D000328:Adult; D000818:Animals; D000917:Antibody Formation; D001249:Asthma / Q000276:immunology / Q000628:therapy*; D003427:Cross Circulation / Q000379:methods*; D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D008297:Male; D012074:Remission Induction; D016060:Sorption Detoxification / Q000379:methods*; D013154:Spleen; D013552:Swine
Kliniko-immunologicheskaia kharakteristika lecheniia bol'nykh s tiazhelym techeniem bronkhial'noĭ astmy metodom ékstrakorporal'nogo podkliucheniia donorskoĭ selezenki svin'i.