title: The clinical and histological features of transitional cell carcinoma of the bladder with microcysts: analysis of 12 cases.
abstract: OBJECTIVE
  To describe the clinical course and histological features of transitional cell carcinoma (TCC) of the bladder with microcysts.
  
  
  METHODS
  Among 940 patients with bladder TCC diagnosed at our institution during a 5 year period. 12 (1.2%; eight men and four women, mean age 71.1 years, range 52-85) were diagnosed histologically as having microcystic TCC. Sections of the tumours were stained with haematoxylin and eosin, periodic acid-Schiff and Alcian blue and clinical data obtained from the patients' records.
  
  
  RESULTS
  Of the 12 patients with bladder TCC with microcysts, three had tumours confined to the epithelium, six had tumour invasion of the lamina propria and three had muscle invasion. One patient had low-grade TCC and 11 had high-grade TCC; six patients had a second primary tumour; three had a colon carcinoma, one a villous adenoma of the caecum, one a locally advanced carcinoma of the prostate and the last a squamous cell carcinoma of the uterine cervix.
  
  
  CONCLUSIONS
  Microcystic TCC was associated with high-stage and high-grade bladder tumours and with other primary tumours, especially of the colon. Screening these patients for asymptomatic tumours of the colon is suggested.
authors.affiliation: Department of Urology, Rabin Medical Center, Petah-Tiqva, Israel.
authors.forename: A
authors.initials: A
authors.lastname: Paz
authors.forename: L
authors.initials: L
authors.lastname: Rath-Wolfson
authors.forename: D
authors.initials: D
authors.lastname: Lask
authors.forename: R
authors.initials: R
authors.lastname: Koren
authors.forename: A
authors.initials: A
authors.lastname: Manes
authors.forename: E
authors.initials: E
authors.lastname: Mukamel
authors.forename: R
authors.initials: R
authors.lastname: Gal
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001500:BCG Vaccine / Q000627:therapeutic use; D002295:Carcinoma, Transitional Cell / Q000473:pathology* / Q000628:therapy; D003560:Cysts / Q000473:pathology* / Q000628:therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local; D016609:Neoplasms, Second Primary / Q000473:pathology / Q000628:therapy; D001749:Urinary Bladder Neoplasms / Q000473:pathology* / Q000628:therapy
chemical_list: D001500:BCG Vaccine