title: Markers of acute airway inflammation.
abstract: In asthma, acute inflammation induced by allergen challenge in allergic patients leads to an early and a late phase reaction. Immunoglobulin E (IgE)-mediated cell activation plays a crucial role in acute inflammation and leads to the release of proinflammatory mediators, such as histamine, eicosanoids, platelet-activating factor, oxygen-free radicals, neuropeptides and cytokines. These mediators are capable of inducing constriction of airways smooth muscle, increased secretion of mucus, and vasodilatation, as well as several important biological events, including modulation of the expression of adhesion molecules in endothelial and epithelial cells, and of inflammatory cell recruitment. Clinically, acute airway inflammation is characterized by a bronchoconstrictive response with acute symptoms, including wheezing and dyspnoea which can be reversed by short-acting bronchodilators, among which beta 2-agonists play a major role.
authors.affiliation: Istituto di Fisiopatologia Respiratoria, C.N.R., Palermo, Italy.
authors.forename: A M
authors.initials: AM
authors.lastname: Vignola
authors.forename: A M
authors.initials: AM
authors.lastname: Merendino
authors.forename: G
authors.initials: G
authors.lastname: Chiappara
authors.forename: P
authors.initials: P
authors.lastname: Chanez
authors.forename: E
authors.initials: E
authors.lastname: Pace
authors.forename: L
authors.initials: L
authors.lastname: Siena
authors.forename: M
authors.initials: M
authors.lastname: Profita
authors.forename: J
authors.initials: J
authors.lastname: Bousquet
authors.forename: G
authors.initials: G
authors.lastname: Bonsignore
mesh_terms: D001249:Asthma / Q000276:immunology / Q000503:physiopathology*; D016084:Bronchoconstriction / Q000276:immunology / Q000502:physiology; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism / Q000502:physiology
chemical_list: D018836:Inflammation Mediators