title: Noise stress does not modulate effects of smoking/nicotine on beta-endorphin, cortisol, ACTH, glucose, and mood.
abstract: Noise-dependent effects of smoking multiple cigarettes on subjective state and blood concentrations of ACTH, beta-endorphin, cortisol, and glucose were assessed in a repeated measures design where noise level (high versus minimal) was crossed with nicotine dose (quasi-ad lib own brand versus 1.0 mg FTC nicotine machine-delivered dose versus 0.05 mg FTC nicotine machine-delivered dose). Cortisol and ACTH were increased by nicotine, but not by noise and there was no noise by dose interaction. In contrast, nicotine did not increase beta-endorphin in either noise condition and there was no dose by noise interaction for beta-endorphin. However, noise was associated with a modest increase in beta-endorphin. The effects of nicotine on blood glucose varied as a function of the number of cigarettes smoked. However, the effects of nicotine on glucose, hormones, and subjective state did not vary as a function of noise stress.
authors.affiliation: Department of Psychology, Southern Illinois University, Carbondale 62901, USA.
authors.forename: D G
authors.initials: DG
authors.lastname: Gilbert
authors.forename: C J
authors.initials: CJ
authors.lastname: Meliska
authors.forename: L C
authors.initials: LC
authors.lastname: Plath
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000097:blood*; D000328:Adult; D000339:Affect / Q000187:drug effects*; D001786:Blood Glucose / Q000032:analysis*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D008297:Male; D009538:Nicotine / Q000494:pharmacology*; D009622:Noise; D012907:Smoking / Q000009:adverse effects* / Q000523:psychology; D001615:beta-Endorphin / Q000097:blood*
chemical_list: D001786:Blood Glucose; D001615:beta-Endorphin; D009538:Nicotine; D000324:Adrenocorticotropic Hormone; D006854:Hydrocortisone