[Treatment of euthyroid struma. Comparable volume reduction with 400 micrograms iodine, 100 micrograms levothyroxine combined with 100 micrograms iodine or individually dosed levothyroxine].
OBJECTIVE
In patients with euthyroid goitre, the efficacy of treatment with 400 micrograms iodine and 100 micrograms levothyroxine combined with 100 micrograms iodine was compared to that of the previous standard of therapy, individually dosed levothyroxine.


METHODS
A total of 78 patients presenting with euthyroid diffuse goitre (> or = 25 ml) were prospectively enrolled, randomised and treated for 6 months. The course of thyroid volume was followed using thyroid volumetry.


RESULTS
Data of 69 patients were included in the final evaluation (57 women, 12 men, age 31 +/- 1 years, thyroid volume 31.5 +/- 1.4 ml, 23 per treatment group). In the patients treated with individually dosed levothyroxine, the thyroid volume decreased by about 39% (95%-confidence limit [CL]-31% to -41%). However, the volume reductions achieved in the patients treated with 400 micrograms iodine or 100 micrograms levothyroxine/100 micrograms iodine were not significantly different (p = 0.35, variance analysis, mono-iodine -34%, 95%-CL -29% to -43%, 100 micrograms levothyroxine/100 micrograms iodine -39%, 95%-CL -32% to -45%).


CONCLUSIONS
In patients with euthyroid diffuse goitre, treatment with mono-iodine or combination of levothyroxine with iodine should have principally the same status as the previous standard of therapy, individually dosed levothyroxine. In the view of the authors, its preferential treatment with mono-iodine appears most reasonable.
Peters
H
H
Medizinische Klinik und Poliklinik, Klinikum Benjamin Franklin, Freie Universität Berlin.
Hackel
D
D
Schleusener
H
H
D000328:Adult; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D005067:Euthyroid Sick Syndromes / Q000000981:diagnostic imaging / Q000188:drug therapy*; D005260:Female; D006043:Goiter, Endemic / Q000000981:diagnostic imaging / Q000188:drug therapy*; D006801:Humans; D007455:Iodine / Q000008:administration & dosage*; D008297:Male; D011446:Prospective Studies; D013960:Thyroid Function Tests; D013961:Thyroid Gland / Q000000981:diagnostic imaging / Q000187:drug effects; D013974:Thyroxine / Q000008:administration & dosage*; D016896:Treatment Outcome; D014463:Ultrasonography
D007455:Iodine; D013974:Thyroxine
Behandlung der euthyreoten Struma. Vergleichbare Volumenreduktion mit 400 micrograms Jodid, 100 micrograms Levothyroxin kombiniert mit 100 micrograms Jodid oder individuell dosiertem Levothyroxin.