title: Detailed quality of life assessment in patients treated with primary radiotherapy for squamous cell cancer of the base of the tongue.
abstract: BACKGROUND
  This study was conducted to evaluate quality of life in patients treated with primary radiotherapy (RT) for cancer of the base of tongue.
  
  
  METHODS
  From 1981 to 1990, 36 patients with primary squamous cell cancer of the base of tongue were managed with primary radiotherapy. Ages ranged from 35 to 71 years (median, 58 years), T Stage was: T1, n = 11; T2, n = 14; T3, n = 10; T4, n = 1. Thirty-one patients (86%) had palpable cervical lymph node metastases at initial examination (N1, n = 16; N2, n = 11; N3, n = 4). Patients received external beam RT to their primary site and necks, followed by a brachytherapy boost to the tongue. Those with neck nodes also had a neck dissection. The median follow-up is 5 years (minimum, 3 years). Actuarial 5-year local control was 85%; regional control was 96%; distant metastases-free survival was 87.5%; and overall survival, 85%. Twenty-nine of the 30 long-term survivors completed (1) Memorial Symptom Assessment Scale (MSAS), (2) Functional Assessment of Cancer Therapy (FACT), (3) Performance Status Scale for Head and Neck Cancer (PSS), and (4) a sociodemographic and economic questionnaire. At the time of cancer diagnosis, 62% were employed full-time, and 21% were employed part-time; 83% were earning > $20,000/year, and 59% were earning > $60,000/year.
  
  
  RESULTS
  At follow-up, annual incomes were similar to those at initial examination. Of those who had been working full-time, 72% were still in full-time work, and of those who had been working part-time, 83% were still in part-time work. Average PSS scores were 90 for eating in public, 96 for understandability of speech, and 68 for normalcy of diet. On the MSAS, the following symptoms had prevalence: > 30% xerostomia, difficulty swallowing, decreased energy, pain, worrying, insomnia, cough, drowsy, change in taste, and irritability. Scores on the FACT exceeded published values collected for a mixed cancer population.
  
  
  CONCLUSIONS
  The overwhelming majority of patients achieved excellent functional status and quality of life and could maintain their prediagnosis earning potential and employment status after primary radiation for advanced base of tongue cancer.
authors.affiliation: Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.
authors.forename: L B
authors.initials: LB
authors.lastname: Harrison
authors.forename: M J
authors.initials: MJ
authors.lastname: Zelefsky
authors.forename: D G
authors.initials: DG
authors.lastname: Pfister
authors.forename: E
authors.initials: E
authors.lastname: Carper
authors.forename: A
authors.initials: A
authors.lastname: Raben
authors.forename: D H
authors.initials: DH
authors.lastname: Kraus
authors.forename: E W
authors.initials: EW
authors.lastname: Strong
authors.forename: A
authors.initials: A
authors.lastname: Rao
authors.forename: H
authors.initials: H
authors.lastname: Thaler
authors.forename: T
authors.initials: T
authors.lastname: Polyak
authors.forename: R
authors.initials: R
authors.lastname: Portenoy
mesh_terms: D000206:Actuarial Analysis; D000223:Adaptation, Psychological; D000328:Adult; D000368:Aged; D001918:Brachytherapy; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000523:psychology / Q000532:radiotherapy* / Q000556:secondary; D015331:Cohort Studies; D018572:Disease-Free Survival; D004651:Employment; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011788:Quality of Life; D011829:Radiation Dosage; D012959:Socioeconomic Factors; D011795:Surveys and Questionnaires; D015996:Survival Rate; D014062:Tongue Neoplasms / Q000401:mortality / Q000523:psychology / Q000532:radiotherapy*