title: Middle ear overpressure treatment of endolymphatic hydrops in guinea pigs.
abstract: Guinea pigs placed outside or inside a pressure chamber and exposed to 49.2 cm H2O overpressure continuously for 24 h immediately after blockage of the endolymphatic duct showed no significant difference in the magnitude of endolymphatic hydrops when compared to controls, although there was a slight indication of a volume decrease in the outside-treatment group and an increase in the inside-treatment group. A pressure increase of 49.2 cm H2O in the external auditory canal for 1 h twice a day for 2 weeks outside the chamber significantly inhibited the development of hydrops. The latter result supports the merit of pressure application through the external auditory canal as a treatment for Meniere's disease.
authors.affiliation: Department of Otology and Laryngology, Harvard Medical School, Boston, Mass., USA.
authors.forename: Y
authors.initials: Y
authors.lastname: Sakikawa
authors.forename: R S
authors.initials: RS
authors.lastname: Kimura
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001274:Atmospheric Pressure; D003051:Cochlea / Q000473:pathology; D003053:Cochlear Duct / Q000473:pathology; D004195:Disease Models, Animal; D004432:Ear, Middle; D018159:Endolymphatic Hydrops / Q000473:pathology / Q000628:therapy*; D006168:Guinea Pigs; D008575:Meniere Disease / Q000628:therapy; D013997:Time Factors