[Reversible dementia due to valproic acid therapy].
A progressive dementia syndrome (DSM IV) with frontal-subcortical features developed in a 72-year-old woman during valproate therapy (Depakine). Discontinuation of valproate resulted in complete recovery. Drugs are a common cause of reversible dementia. The association of dementia with valproate therapy is rare. Features of a subcortical dementia are indicative of a reversible cause. In addition, the possible role of drugs should always be considered in patients with cognitive decline.
Walstra
G J
GJ
Academisch Medisch Centrum, afd. Neurologie, Amsterdam.
D000368:Aged; D000927:Anticonvulsants / Q000009:adverse effects*; D003704:Dementia / Q000139:chemically induced* / Q000175:diagnosis / Q000473:pathology; D004830:Epilepsy, Tonic-Clonic / Q000188:drug therapy; D005260:Female; D005625:Frontal Lobe / Q000473:pathology; D006801:Humans; D014635:Valproic Acid / Q000009:adverse effects*
D000927:Anticonvulsants; D014635:Valproic Acid
Reversibele dementie bij gebruik van valproïnezuur.