[Cancer and the regional lymph nodes (immunohistochemical and ultrastructural studies)].
153 regional lymph nodes obtained during surgical operations because of cancer of various cites from 50 cancer patients were studied. Failure of local immunity is explained by the following factors: 1) depletion of T-cell population with a decrease of activated lymphocyte-killers; 2) high activity of B-cell population able to block T-cell cytotoxic effect; 3) deficiency of T-suppressors and T-helpers; 4) a decrease of macrophages-monocytes of phagocytic capacity; 5) high activity of dendritic reticular cells stimulating transformation of B-lymphocytes and low activity of interdigitating reticulocytes determining T-cell immunity stimulation.
Tsyplakov
D E
DE
Petrov
S V
SV
D000917:Antibody Formation; D001402:B-Lymphocytes / Q000276:immunology; D003602:Cytotoxicity, Immunologic; D006801:Humans; D007150:Immunohistochemistry; D008198:Lymph Nodes / Q000737:chemistry* / Q000276:immunology / Q000648:ultrastructure; D008207:Lymphatic Metastasis; D008213:Lymphocyte Activation; D018655:Lymphocyte Count; D008854:Microscopy, Electron; D009369:Neoplasms / Q000737:chemistry* / Q000276:immunology / Q000648:ultrastructure; D012307:Risk Factors; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
Rak i regionarnykh limfaticheskie uzly (immunogistokhimicheskoe i ul'trastrukturnoe issledovanie).