The effect of vitamin C and vitamin E supplementation on bacterial translocation in chronic portal hypertensive and common-bile-duct-ligated rats.
In rats with chronic portal hypertension (PH) and common bile duct ligation (CBDL), significant ileal bacterial overgrowth, translocation of indigenous intestinal bacteria, a decrease in hepatic and ileal reduced glutathione (GSH) and an increase in ileal mucosal lipid peroxidation occur. alpha-Tocopherol (vitamin E) and ascorbic acid (vitamin C) treatment attenuated the incidence of bacterial translocation, improved hepatic and ileal GSH levels and decreased ileal mucosal lipid peroxidation. These results suggest that in chronic PH and CBDL oxidative processes in the liver and intestine play an important role for bacterial translocation.
Schimpl
G
G
Department of Pediatric Surgery, University of Graz Medical School, Austria.
Pesendorfer
P
P
Steinwender
G
G
Feierl
G
G
Ratschek
M
M
Höllwarth
M E
ME
D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology*; D018988:Bacterial Translocation / Q000187:drug effects*; D015415:Biomarkers / Q000032:analysis; D002779:Cholestasis / Q000382:microbiology*; D003135:Common Bile Duct; D005978:Glutathione / Q000378:metabolism; D006975:Hypertension, Portal / Q000378:metabolism / Q000382:microbiology*; D007082:Ileum / Q000378:metabolism / Q000382:microbiology; D007413:Intestinal Mucosa / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects*; D008099:Liver / Q000378:metabolism / Q000382:microbiology; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D014810:Vitamin E / Q000494:pharmacology*
D015415:Biomarkers; D014810:Vitamin E; D005978:Glutathione; D001205:Ascorbic Acid