[Role of membrane protectors and antioxidants in the process of perfusion and preservation of donor lungs].
Comparative study of the effect of four perfusion and preservation solutions on lung function, conducted in experiments on 69 inbred dogs, revealed the following regular features. Euro-Collins and electrolyte solutions cause a marked increase of the capillary-hydrostatic pressure, a significant decrease of colloido-osmotic pressure of the plasma, and, as a result, reduction of the ient between them. This is manifested by edema of the lungs. The use of LPD solution is attended by moderate edema of the lungs in moderately increased capillary hydrostatic pressure and mildly reduced colloido-osmotic pressure of the plasma. Perfusion and preservation of the lungs with the LPD solution, containing membrane protectors and antioxidants, for 12 hours is marked by practically unchanged indices of capillary-hydrostatic pressure, plasma coloido-osmotic pressure, and the gradient between them. Edema of the lungs does not develop in this case.
Khodzhimatov
G M
GM
Scientific Center of Surgery, Moscow.
Movsesov
R V
RV
Zhidkov
I L
IL
Zhavoronkov
N A
NA
Ivanova
A G
AG
Dement'eva
I I
II
Perel'man
M I
MI
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002462:Cell Membrane / Q000187:drug effects; D004285:Dogs; D004338:Drug Combinations; D005260:Female; D006982:Hypertonic Solutions / Q000494:pharmacology; D066298:In Vitro Techniques; D008168:Lung / Q000187:drug effects / Q000502:physiology*; D008297:Male; D009926:Organ Preservation / Q000379:methods*; D019188:Organ Preservation Solutions / Q000494:pharmacology*; D010477:Perfusion / Q000379:methods*; D011654:Pulmonary Edema / Q000473:pathology / Q000517:prevention & control
D000975:Antioxidants; D004338:Drug Combinations; C037096:Euro-Collins' solution; D006982:Hypertonic Solutions; D019188:Organ Preservation Solutions
Rol' membranoprotektorov i antioksidantov v protsesse perfuzii i konservatsii donorskikh legkikh.