The depletion of substance P by diclofenac in the mouse.
Diclofenac in hyaluronan is analgesic and angiostatic. The depletion of substance P may be a common mechanism. Mice received diclofenac, diclofenac in hyaluronan, or saline i.v. for 5 days and snout substance P assessed: saline 2.80 +/- 0.23; 0.5 mg/kg diclofenac 2.03 +/- 0.20 (P < 0.05); diclofenac in hyaluronan 1.88 +/- 0.21 (P < 0.02); capsaicin 1.45 +/- 0.26 fmol/mg tissue (P < 0.005). Substance P recovered by 5 days (diclofenac in hyaluronan, capsaicin) and 24 h (diclofenac). Diclofenac may deplete substance P in analgesia, and hyaluronan prolong the depletion.
Papworth
J
J
Department of Experimental Pathology, William Harvey Research Institute, Saint Bartholomew's and the Royal London Hospital School of Medicine and Dentistry, UK.
Colville-Nash
P
P
Alam
C
C
Seed
M
M
Willoughby
D
D
D000700:Analgesics / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D004008:Diclofenac / Q000008:administration & dosage / Q000494:pharmacology*; D016503:Drug Delivery Systems; D005260:Female; D006820:Hyaluronic Acid / Q000008:administration & dosage; D051379:Mice; D013373:Substance P / Q000378:metabolism*
D000700:Analgesics; D004008:Diclofenac; D013373:Substance P; D006820:Hyaluronic Acid