title: [The system of hemostasis in experimental liver transplantation].
abstract: The status of haemostatic factors in 28 pigs after orthotopic liver transplantation was evaluated. The major changes took place in fibrinolytic system during the "non-liver" stage: rapid increase of fibrinolytic activity, plasmin activity, plasmin activator activity. From the moment of blood supply restoration to a transplanted liver the tendency to normalisation of fibrinolysis was detected. The deficiency of plasma haemostatic factors and platelets has increased during all the follow-up period and should be corrected in time. The following principles of corrective therapy are formulated: inhibition of fibrinolysis, correction of antithrombin-3 and blood clotting factors. Correction of haemostasis should be done in "pre-non-liver" period and later in "non-liver" reperfusion periods.
authors.affiliation: Scientific Center of Surgery, Moscow.
authors.forename: I L
authors.initials: IL
authors.lastname: Zhidkov
authors.forename: I E
authors.initials: IE
authors.lastname: Michailov
authors.forename: N K
authors.initials: NK
authors.lastname: Broun
authors.forename: L A
authors.initials: LA
authors.lastname: Smirnova
authors.forename: V V
authors.initials: VV
authors.lastname: Buianov
authors.forename: A K
authors.initials: AK
authors.lastname: Eramishantsev
mesh_terms: D000818:Animals; D000990:Antithrombin III / Q000378:metabolism; D001778:Blood Coagulation Disorders / Q000097:blood* / Q000188:drug therapy / Q000209:etiology; D001779:Blood Coagulation Factors / Q000378:metabolism; D005260:Female; D005341:Fibrinolysin / Q000378:metabolism; D005343:Fibrinolytic Agents / Q000627:therapeutic use; D005500:Follow-Up Studies; D006487:Hemostasis / Q000187:drug effects / Q000502:physiology*; D016031:Liver Transplantation / Q000009:adverse effects; D008297:Male; D011183:Postoperative Complications; D013552:Swine; D013556:Swine, Miniature; D015912:Thrombolytic Therapy / Q000379:methods
chemical_list: D001779:Blood Coagulation Factors; D005343:Fibrinolytic Agents; D000990:Antithrombin III; D005341:Fibrinolysin
vernacular_title: Sistema gemostaza transplantatsii pecheni v eksperimente.