title: Glucocorticoid-induced ketoacidosis in gestational diabetes: sequela of the acute treatment of preterm labor. A case report.
abstract: Pregnancy induces complex changes in energy metabolism, manifested clinically by insulin resistance, low fasting blood glucose levels, and proneness to ketosis. It is quite unusual for pregnant women who do not have type I diabetes to progress from ketosis to frank ketoacidosis, although this phenomenon is common in larger mammals. In the case described here, glucocorticoid administration in the setting of a prolonged fast triggered a metabolic cascade leading to ketoacidosis in a pregnant woman without type 1 diabetes. Other details of this illustrative case serve to synthesize several disparate observations regarding the pathogenesis of pregnancy ketoacidosis. Physicians should be aware of the potential for rapidly developing ketoacidosis with atypical biochemical and clinical features in pregnant women who are treated with high doses of glucocorticoids.
authors.affiliation: Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA.
authors.forename: A
authors.initials: A
authors.lastname: Bedalov
authors.forename: A
authors.initials: A
authors.lastname: Balasubramanyam
mesh_terms: D000328:Adult; D001623:Betamethasone / Q000009:adverse effects*; D001806:Blood Urea Nitrogen; D003404:Creatinine / Q000097:blood; D003920:Diabetes Mellitus; D016640:Diabetes, Gestational / Q000097:blood / Q000503:physiopathology*; D016883:Diabetic Ketoacidosis / Q000139:chemically induced* / Q000503:physiopathology / Q000628:therapy; D004573:Electrolytes / Q000097:blood; D005260:Female; D005938:Glucocorticoids / Q000009:adverse effects*; D005947:Glucose / Q000008:administration & dosage; D006801:Humans; D007262:Infusions, Intravenous; D007328:Insulin / Q000627:therapeutic use; D008168:Lung / Q000196:embryology; D009765:Obesity; D007752:Obstetric Labor, Premature / Q000517:prevention & control*; D011247:Pregnancy
chemical_list: D004573:Electrolytes; D005938:Glucocorticoids; D007328:Insulin; D001623:Betamethasone; D003404:Creatinine; D005947:Glucose