Vesicle traffic: get your coat!
The budding of transport vesicles from the Golgi complex is initiated by activation of the small GTPase ARF; the discovery of enzymes that can convert soluble ARF-GDP to the active, membrane-associated form ARF-GTP will shed light on the mechanism and regulation of the formation of transport vesicles.
Schimmöller
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Department of Biochemistry, Stanford University School of Medicine, Stanford, California 94305-5307, USA.
Itin
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Pfeffer
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D020727:ADP-Ribosylation Factors; D000818:Animals; D018699:Coated Vesicles / Q000502:physiology* / Q000648:ultrastructure; D005656:Fungal Proteins / Q000502:physiology; D020558:GTP Phosphohydrolases / Q000378:metabolism*; D019204:GTP-Binding Proteins / Q000378:metabolism* / Q000502:physiology; D006056:Golgi Apparatus / Q000502:physiology*; D020662:Guanine Nucleotide Exchange Factors; D006153:Guanosine Diphosphate / Q000378:metabolism; D008954:Models, Biological; D008961:Models, Structural; D012441:Saccharomyces cerevisiae / Q000502:physiology* / Q000648:ultrastructure; D029701:Saccharomyces cerevisiae Proteins
D005656:Fungal Proteins; C102475:GEA1 protein, S cerevisiae; D020662:Guanine Nucleotide Exchange Factors; D029701:Saccharomyces cerevisiae Proteins; C066755:Sec7 guanine nucleotide exchange factors; D006153:Guanosine Diphosphate; D020558:GTP Phosphohydrolases; D019204:GTP-Binding Proteins; D020727:ADP-Ribosylation Factors