title: Effect of ethanol and fructose on plasma uridine and purine bases.
abstract: To determine whether both ethanol and fructose increase the plasma concentration of uridine, we administered ethanol (0.6 g/kg) or fructose (1.0 g/kg) to seven normal subjects. Both ethanol and fructose increased the plasma concentration of uridine together with an increase in the plasma concentration of oxypurines, whereas fructose also increased the plasma concentration of uric acid, but ethanol did not. In ethanol ingestion and fructose infusion, an increase in the plasma concentration of purine bases correlated with that of uridine. These results strongly suggest that an increase in the plasma concentration of uridine is ascribable to increased pyrimidine degradation following purine degradation increased by ethanol and fructose.
authors.affiliation: Third Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Yamamoto
authors.forename: Y
authors.initials: Y
authors.lastname: Moriwaki
authors.forename: S
authors.initials: S
authors.lastname: Takahashi
authors.forename: J
authors.initials: J
authors.lastname: Yamakita
authors.forename: Z
authors.initials: Z
authors.lastname: Tsutsumi
authors.forename: H
authors.initials: H
authors.lastname: Ohata
authors.forename: K
authors.initials: K
authors.lastname: Hiroishi
authors.forename: T
authors.initials: T
authors.lastname: Nakano
authors.forename: K
authors.initials: K
authors.lastname: Higashino
mesh_terms: D000328:Adult; D000428:Alcohol Drinking; D000431:Ethanol / Q000097:blood / Q000494:pharmacology*; D005632:Fructose / Q000097:blood / Q000494:pharmacology*; D006801:Humans; D019271:Hypoxanthine / Q000097:blood; D007262:Infusions, Intravenous; D007773:Lactates / Q000097:blood; D008297:Male; D008875:Middle Aged; D009994:Osmolar Concentration; D010710:Phosphates / Q000097:blood; D011687:Purines / Q000097:blood*; D011773:Pyruvates / Q000097:blood; D014527:Uric Acid / Q000097:blood; D014529:Uridine / Q000097:blood*; D019820:Xanthine; D014970:Xanthines / Q000097:blood
chemical_list: D007773:Lactates; D010710:Phosphates; D011687:Purines; D011773:Pyruvates; D014970:Xanthines; D019820:Xanthine; D014527:Uric Acid; D019271:Hypoxanthine; D005632:Fructose; D000431:Ethanol; D014529:Uridine