Inhibitory effects on Epstein-Barr virus activation of anthraquinones: correlation with redox potentials.
The redox potentials have been determined for nine anthraquinones in phosphate buffer at pH 7.2 by means of cyclic voltammetry. A definite correlation has been found between the redox potentials and the inhibitory effects of the anthraquinones on the EBV-EA activation. It has further been shown that the correlation can be made better by introducing an electronic property, i.e. the atomic charge at O12 as an additional parameter.
Koyama
J
J
Faculty of Pharmaceutical Sciences, Kobe Pharmaceutical University, Higashinada, Japan.
Tagahara
K
K
Osakai
T
T
Tsujino
Y
Y
Tsurumi
S
S
Nishino
H
H
Tokuda
H
H
D000880:Anthraquinones / Q000737:chemistry* / Q000494:pharmacology*; D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D000956:Antigens, Viral / Q000502:physiology; D002273:Carcinogens / Q000494:pharmacology; D004563:Electrochemistry; D004854:Herpesvirus 4, Human / Q000187:drug effects* / Q000254:growth & development*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008214:Lymphocytes / Q000187:drug effects / Q000821:virology; D010084:Oxidation-Reduction; D010100:Oxygen / Q000737:chemistry; D013755:Tetradecanoylphorbol Acetate / Q000037:antagonists & inhibitors / Q000494:pharmacology; D014775:Virus Activation / Q000187:drug effects*
D000880:Anthraquinones; D016588:Anticarcinogenic Agents; D000956:Antigens, Viral; D002273:Carcinogens; C033305:Epstein-Barr virus early antigen; D013755:Tetradecanoylphorbol Acetate; D010100:Oxygen