[123I-alpha-methyltyrosine scintigraphy in malignant melanoma].
OBJECTIVE
The aim of the study was to evaluate the ranking of the scintigraphy with L-3-123I-alpha-methyltyrosine (123I-AMT) in metastasized melanoma.


METHODS
26 metastases and one primary tumor of a malignant melanoma in six patients were examined with 123I-AMT whole-body scintigraphy and SPECT. Positron Emission Tomography with 2-18F-fluoro-2-desoxy-D-glucose (18F-FDG) was used as the golden standard.


RESULTS
With 123I-AMT-SPECT 8/10 metastases in the thorax > 1.6 cm were detected (ratio T/NT 1.2-1.8), metastases < 1.6 cm were not detectable with SPECT. In 123I-AMT whole-body scintigraphy not one lesion showed a positive tumor uptake.


CONCLUSIONS
In single cases 123I-AMT scintigraphy can be helpful in staging of malignant melanoma.
Steinert
H
H
Departement Medizinische Radiologie, Klinik für Nuklearmedizin, Universitätsspital Zürich, Schweiz.
Böni
R
R
Huch-Böni
R A
RA
Capaul
R
R
von Schulthess
G K
GK
Westera
G
G
D000328:Adult; D000368:Aged; D003847:Deoxyglucose / Q000031:analogs & derivatives; D005260:Female; D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D006801:Humans; D007457:Iodine Radioisotopes; D008297:Male; D008545:Melanoma / Q000000981:diagnostic imaging* / Q000473:pathology; D008781:Methyltyrosines; D008875:Middle Aged; D009362:Neoplasm Metastasis; D013899:Thoracic Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary; D014055:Tomography, Emission-Computed; D015899:Tomography, Emission-Computed, Single-Photon; D019805:alpha-Methyltyrosine
D005462:Fluorine Radioisotopes; D007457:Iodine Radioisotopes; D008781:Methyltyrosines; D019788:Fluorodeoxyglucose F18; D019805:alpha-Methyltyrosine; D003847:Deoxyglucose
123I-alpha-Methyltyrosin-Szintigraphie beim malignen Melanom.