title: Recurrent Streptococcus pneumoniae sepsis in children with sickle cell disease.
abstract: Streptococcus pneumoniae sepsis is the most common invasive infection among patients with sickle cell disease. The risk of a recurrent episode of sepsis and subsequent death in those patients who have had a previous septic event is much higher. Patients with sickle disease who have had pneumococcal sepsis should continue penicillin prophylaxis indefinitely and should not be candidates for out-patient management of febrile episodes.
authors.affiliation: Department of Hematology/Oncology, St. Jude Children's Research Hospital, Memphis, TN 38101, USA.
authors.forename: S
authors.initials: S
authors.lastname: Hongeng
authors.forename: J A
authors.initials: JA
authors.lastname: Wilimas
authors.forename: S
authors.initials: S
authors.lastname: Harris
authors.forename: S W
authors.initials: SW
authors.lastname: Day
authors.forename: W C
authors.initials: WC
authors.lastname: Wang
mesh_terms: D000755:Anemia, Sickle Cell / Q000150:complications* / Q000188:drug therapy*; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D010349:Patient Compliance; D010406:Penicillins / Q000627:therapeutic use*; D011008:Pneumococcal Infections / Q000209:etiology* / Q000401:mortality / Q000517:prevention & control; D012008:Recurrence; D012307:Risk Factors; D018805:Sepsis / Q000209:etiology* / Q000401:mortality / Q000517:prevention & control; D016896:Treatment Outcome
chemical_list: D010406:Penicillins