[Age-related changes in the effect of catecholamines on spontaneous periodic motor activity in rat pups].
Reaction of spontaneous periodic motor activity (SPMA) to exogenous increase of catecholamine (CA) level in brain by means of L-DOPA injection or other methods of catecholaminergic system activation undergoes quite essential changes in process of early postnatal ontogenesis. Possible causes of such age changes are considered in present paper: 1) increase of SPMA reactivity to CA level change; 2) heterochronic development of dopamine- and adrenergic systems; 3) heterochronia in maturation of SPMA activation and inhibition mechanisms; 4) maturation of its regulation levels. It was shown that activation of catecholamine systems resulted in changes of SPMA levels in the same direction as its natural age dynamics occurred: enhancement in growth period on the first week after birth, and subsequent decrease of activating and appearance of inhibitory effects in period of SPMA age inhibition.
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D000375:Aging / Q000187:drug effects* / Q000502:physiology; D000818:Animals; D002395:Catecholamines / Q000494:pharmacology*; D009043:Motor Activity / Q000187:drug effects* / Q000502:physiology; D010507:Periodicity; D051381:Rats
D002395:Catecholamines
O vozrastnykh izmeneniiakh vliianiia katekholaminov na spontannuiu periodicheskuiu motornuiu aktivnost' krysiat.