title: [The effect of choleragen poisoning on the intestinal apudocytes of gnotobiotic minipigs].
abstract: Intragastric administration of the cholera toxin to gnotobiotic mini-pigs results in cyclic morphofunctional alterations of intestinal apudocytes followed by their degranulation, a decrease in their number from 1 to 3 hrs and after 18 hrs, while a slight increase in their number occurred from 3 to 12 hrs. The response of APUD-system cells is similar in large and small intestine. Products of apudocyte secretion may be involved in the diarrheogenic effect of the cholera toxin.
authors.forename: I V
authors.initials: IV
authors.lastname: Isupov
authors.forename: S A
authors.initials: SA
authors.lastname: Bugorkova
authors.forename: L S
authors.initials: LS
authors.lastname: Nazarova
mesh_terms: D001078:APUD Cells / Q000187:drug effects* / Q000473:pathology; D000818:Animals; D002772:Cholera Toxin / Q000008:administration & dosage / Q000506:poisoning*; D005856:Germ-Free Life / Q000187:drug effects*; D007422:Intestines / Q000187:drug effects* / Q000473:pathology; D011041:Poisoning / Q000473:pathology; D013552:Swine; D013556:Swine, Miniature; D013997:Time Factors
chemical_list: D002772:Cholera Toxin
vernacular_title: Vliianie kholerogennoĭ intoksikatsii na apudotsity kishechnika gnotobioticheskikh mini-porosiat.