title: Hospitalization for serious blood and skin disorders following use of co-trimoxazole.
abstract: OBJECTIVE
  The objective of this study was to quantify the risk of serious blood and skin disorders associated with co-trimoxazole.
  
  
  METHODS
  We conducted a population-based cohort study of serious blood and skin disorders requiring hospitalization among otherwise healthy users of co-trimoxazole at Group Health Cooperative and Puget Sound (GHC).
  
  
  RESULTS
  During the years 1987 to 1993 we found six cases of co-trimoxazole-associated blood disorders and three cases of co-trimoxazole-associated skin disorders yielding risks of 5.6/100,000 (95% CI 2.6-12.2) and 2.8/100,000 (95% CI 0.9-8.2) respectively. In all cases found there was prompt recovery after discontinuation of co-trimoxazole. We found no cases of toxic epidermal necrolysis.
  
  
  CONCLUSIONS
  We conclude that the risk of blood and skin disorders associated with the use of co-trimoxazole leading to hospitalization is low.
authors.affiliation: Boston Collaborative Drug Surveillance Program, Boston University Medical Center, Lexington, Massachussetts, USA.
authors.forename: M W
authors.initials: MW
authors.lastname: Myers
authors.forename: H
authors.initials: H
authors.lastname: Jick
mesh_terms: D000328:Adult; D000368:Aged; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000009:adverse effects*; D002675:Child, Preschool; D015331:Cohort Studies; D004892:Erythema Multiforme / Q000139:chemically induced; D005260:Female; D006402:Hematologic Diseases / Q000139:chemically induced*; D006760:Hospitalization / Q000706:statistics & numerical data*; D006801:Humans; D007970:Leukopenia / Q000139:chemically induced; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009503:Neutropenia / Q000139:chemically induced; D010198:Pancytopenia / Q000139:chemically induced; D018570:Risk Assessment; D012871:Skin Diseases / Q000139:chemically induced*; D013262:Stevens-Johnson Syndrome / Q000139:chemically induced; D013921:Thrombocytopenia / Q000139:chemically induced; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D000890:Anti-Infective Agents; D015662:Trimethoprim, Sulfamethoxazole Drug Combination