Host range conversion of murine leukemia virus resulting from recombination with endogenous virus.
Ecotropic murine leukemia viruses (MuLVs) are classified into B-N-, or NB-tropic MuLV by their host range determined by the Fv-1 gene product. B-tropic MuLV is restricted in N-type mouse cells (Fv-1 n/n) and N-tropic MuLV is restricted in B-type mouse cells (FV-1 b/b). Although forced passages in a restrictive host grant a wider host range (NB-tropism), we show here a host range conversion from B to N tropism. The conversion was most likely a result of recombination between the exogenously infected B-tropic MuLV and an endogenously expressed N-tropic MuLV in a C57BL/6 mouse cell line, YH-7.
Kawana
A
A
Department of Infectious Diseases, University of Tokyo, Japan.
Iwamoto
A
A
Odawara
T
T
Yoshikura
H
H
D000818:Animals; D001483:Base Sequence; D018797:Cell Cycle Proteins; D016679:Genome, Viral; D009052:Leukemia Virus, Murine / Q000235:genetics* / Q000472:pathogenicity; D007942:Leukemia, Experimental / Q000235:genetics*; D051379:Mice; D008810:Mice, Inbred C57BL; D008969:Molecular Sequence Data; D009363:Neoplasm Proteins; D011506:Proteins / Q000235:genetics*; D011995:Recombination, Genetic; D012192:Retroviridae Infections / Q000235:genetics*; D014412:Tumor Virus Infections / Q000235:genetics*
D018797:Cell Cycle Proteins; C103189:Fv1 protein, mouse; D009363:Neoplasm Proteins; C498808:Prcc protein, mouse; D011506:Proteins