title: Thyroid follicular neoplasms diagnosed by high-resolution ultrasonography with fine needle aspiration cytology.
abstract: OBJECTIVE
  To investigate the final results of cases with preoperative diagnoses of thyroid follicular neoplasms by fine needle aspiration cytology (FNAC).
  
  
  METHODS
  A retrospective review of 6,499 patients who received thyroid ultrasonography with FNAC at Chang Gung Memorial Hospital. Among 6,499 patients, 209 (3.2%) were diagnosed by FNAC as having follicular neoplasms, of which 84 received surgical treatment. Eighty-two of the 84 cases had a frozen section prepared during the operation.
  
  
  RESULTS
  Thyroid malignancy was confirmed histopathologically in 164 cases. Among 84 thyroid follicular neoplasm patients, 21 cases were diagnosed as malignant tumors, including papillary thyroid carcinoma, follicular thyroid carcinoma, medullary thyroid carcinoma and Hürthle's cell carcinoma. Ultrasonography on these 21 patients revealed that 16 cases (76.2%) had low echo density in the thyroid nodule. The percentage was statistically significantly different from that in benign cases, 23.8% (P < .05). A higher incidence of malignancy was found in males, but the data did not reach statistical significance (P = .0586).
  
  
  CONCLUSIONS
  Most of the follicular neoplasms revealed by FNAC were benign lesions. Low echo density on ultrasonography and male sex carried a higher risk of malignancy.
authors.affiliation: Department of Internal Medicine, Chang Gung Memorial Hospital, Taiwan, Republic of China.
authors.forename: J D
authors.initials: JD
authors.lastname: Lin
authors.forename: C
authors.initials: C
authors.lastname: Hsueh
authors.forename: T C
authors.initials: TC
authors.lastname: Chao
authors.forename: H F
authors.initials: HF
authors.lastname: Weng
authors.forename: B Y
authors.initials: BY
authors.lastname: Huang
mesh_terms: D018263:Adenocarcinoma, Follicular / Q000000981:diagnostic imaging* / Q000473:pathology*; D000293:Adolescent; D000328:Adult; D000368:Aged; D001707:Biopsy, Needle / Q000379:methods*; D002648:Child; D005260:Female; D005629:Frozen Sections; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012737:Sex Factors; D013959:Thyroid Diseases / Q000175:diagnosis / Q000000981:diagnostic imaging; D013964:Thyroid Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology*; D014463:Ultrasonography