title: Autoimmunity: when self-tolerance breaks down.
abstract: The spontaneous development of destructive polyarthritis in mice transgenic for an autoreactive T-cell receptor supports the notion that a failure of T-cell self-tolerance can lead to similar diseases in humans, and sheds new light on the role of peripheral tolerance in the avoidance of such pathological immune responses.
authors.affiliation: Department of Medicine, Center for Immunology at the University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA.
authors.forename: D L
authors.initials: DL
authors.lastname: Mueller
authors.forename: M K
authors.initials: MK
authors.lastname: Jenkins
mesh_terms: D000818:Animals; D001168:Arthritis / Q000235:genetics / Q000276:immunology*; D002417:Cattle; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic; D018448:Models, Immunological; D011948:Receptors, Antigen, T-Cell / Q000096:biosynthesis / Q000235:genetics; D017634:Self Tolerance
chemical_list: D011948:Receptors, Antigen, T-Cell