Management of refractory and complicated reflux esophagitis.
Simple intermittent heartburn with minor or no esophagitis can be treated with simple measures including lifestyle changes and antacids as needed, or H2 receptor antagonists (H2RA), and has a good outcome. Problematic reflux includes resistance to therapy, stricture, Barrett's esophagus and aspiration. Severe reflux esophagitis, often resistant to H2RA therapy, requires more potent treatment with potent acid suppression using proton pump inhibitors, often indefinitely. When complicated by stricture, dilatations with potent acid suppression are needed. Barrett's esophagus is subject to esophagitis, which is no more difficult to treat than other cases of esophagitis. Reflux in Barrett's esophagus should be treated on its own merits without regard to the presence of Barrett's epithelium. Dysplasia leading to adenocarcinoma is a different problem, apparently not influenced by reduced exposure to acid. Indications for antireflux surgery are quite limited and should be carefully analyzed as a cost/risk/benefit problem.
Hirschowitz
B I
BI
Department of Medicine, University of Alabama at Birmingham 35294, USA. Basil_Hirschowitz@gasmac.dom.uab.edu
D001471:Barrett Esophagus / Q000175:diagnosis / Q000628:therapy; D004940:Esophageal Stenosis / Q000175:diagnosis / Q000628:therapy; D004942:Esophagitis, Peptic / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy*; D006801:Humans