title: Recurrence of duodenal ulcer after Helicobacter pylori eradication is related to high acid output.
abstract: BACKGROUND
  Helicobacter pylori eradication reduces the recurrence of duodenal ulcers. It is unclear why duodenal ulcers rarely recur in the absence of reinfection with H. pylori or NSAID treatment.
  
  
  METHODS
  Basal, gastrin-releasing peptide- and pentagastrin-stimulated peak acid outputs in patients with ulcer relapse after H. pylori eradication were measured, and compared with patients without ulcer relapse after H. pylori eradication.
  
  
  RESULTS
  Pentagastrin-stimulated peak acid output was significantly higher in H. pylori-positive patients with duodenal ulcers than in H. pylori-negative controls, and fell significantly after H. pylori eradication. In H. pylori-negative patients with recurrent duodenal ulcers, pentagastrin-stimulated peak acid output was significantly higher than in controls and similar to H. pylori-positive patients with duodenal ulcers.
  
  
  CONCLUSIONS
  These findings suggest that duodenal ulcer relapse after eradication of H. pylori may be related to high pentagastrin-stimulated peak acid output. In this subset of patients with duodenal ulcers, maintenance anti-secretory treatment may be necessary to prevent relapse.
authors.affiliation: Parkside Helicobacter Study Group, Central Middlesex Hospital, London, UK.
authors.forename: A W
authors.initials: AW
authors.lastname: Harris
authors.forename: P A
authors.initials: PA
authors.lastname: Gummett
authors.forename: P S
authors.initials: PS
authors.lastname: Phull
authors.forename: M R
authors.initials: MR
authors.lastname: Jacyna
authors.forename: J J
authors.initials: JJ
authors.lastname: Misiewicz
authors.forename: J H
authors.initials: JH
authors.lastname: Baron
mesh_terms: D000328:Adult; D004381:Duodenal Ulcer / Q000188:drug therapy / Q000382:microbiology / Q000503:physiopathology*; D005744:Gastric Acid / Q000378:metabolism*; D019886:Gastrin-Releasing Peptide; D016481:Helicobacter Infections / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology*; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D008875:Middle Aged; D010418:Pentagastrin; D010455:Peptides; D012008:Recurrence
chemical_list: D010455:Peptides; D019886:Gastrin-Releasing Peptide; D010418:Pentagastrin