Susceptibility to endometrial cancer: influence of allelism at p53, glutathione S-transferase (GSTM1 and GSTT1) and cytochrome P-450 (CYP1A1) loci.
A case-control study was designed to identify associations between polymorphisms at p53, cytochrome P-450 (CYP1A1) and glutathione-S-transferases and endometrial cancer susceptibility. Among all polymorphisms analysed, an insertional variant in p53 (P53PIN3) and two polymorphisms in the 3'-end and exon 7 of CYP1A1 showed significant association with enhanced endometrial cancer risk.
Esteller
M
M
Unitat de Recerca Biomedica, Centre d'Investigacions en Bioquimica i Biologia Molecular, Hospital Universitari Materno-Infantil Vall d'Hebron, Barcelona, Spain.
García
A
A
Martínez-Palones
J M
JM
Xercavins
J
J
Reventós
J
J
D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D014408:Biomarkers, Tumor; D002277:Carcinoma / Q000209:etiology* / Q000235:genetics / Q000378:metabolism; D016022:Case-Control Studies; D019363:Cytochrome P-450 CYP1A1 / Q000235:genetics* / Q000378:metabolism; D004273:DNA, Neoplasm / Q000032:analysis; D016889:Endometrial Neoplasms / Q000209:etiology* / Q000235:genetics / Q000378:metabolism; D005260:Female; D016158:Genes, p53 / Q000235:genetics*; D005982:Glutathione Transferase / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D008875:Middle Aged; D011110:Polymorphism, Genetic
D014408:Biomarkers, Tumor; D004273:DNA, Neoplasm; D019363:Cytochrome P-450 CYP1A1; D005982:Glutathione Transferase