[Acute cytolytic hepatitis caused by coumarin. 2 cases].
Coumarin is a drug which is extensively used to treat lymphedema. We report two cases of acute hepatitis probably due to coumarin. Two women, 40 year and 45 year-old, were treated with 90 mg/d of coumarin for 5 months. Clinical features included jaundice, pruritus, and diarrhea. A marked increase in serum aminotransferases was observed (ALT: 30 and 100 times the upper limit of normal, respectively). Coumarin withdrawal was rapidly followed by a favorable outcome in both cases. Rechallenge in one case induced a relapse of symptoms and liver test abnormalities. Coumarin can induce acute cytolytic hepatitis.
Koch
S
S
Service d'Hépatologie et de Soins Intensifs Digestifs, CHRU Jean Minjoz, Besançon.
Beurton
I
I
Bresson-Hadni
S
S
Monnot
B
B
Hrusovsky
S
S
Becker
M C
MC
Vanlemmens
C
C
Carbillet
J P
JP
Miguet
J P
JP
D000208:Acute Disease; D000328:Adult; D000925:Anticoagulants / Q000009:adverse effects / Q000627:therapeutic use*; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D003374:Coumarins / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008875:Middle Aged; D014689:Venous Insufficiency / Q000188:drug therapy
D000925:Anticoagulants; D003374:Coumarins; C030123:coumarin
Hépatite aiguë cytolytique à la coumarine. Deux cas.