Isolation and chromosomal mapping of a novel ATP-binding cassette transporter conserved in mouse and human.
We report here on the identification and genomic mapping of a novel member of the family of the ATP-binding cassette (ABC) transporters, ABC7, conserved in mouse and in humans. The ABC7 gene encodes a protein with the typical features of half-transporters, such as those involved in translocation of antigenic peptides or in peroxisomal disorders. ABC7 shows a ubiquitous expression pattern and maps to the X chromosome both in mouse and in humans. The high sequence similarity to those of two yeast half-transporters supports once again the extreme evolutionary conservation of this family of proteins.
Savary
S
S
Centre d'Immunologie, INSERM-CNRS de Marseille Luminy, France.
Allikmets
R
R
Denizot
F
F
Luciani
M F
MF
Mattei
M G
MG
Dean
M
M
Chimini
G
G
D018528:ATP-Binding Cassette Transporters / Q000235:genetics*; D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping; D017124:Conserved Sequence; D018076:DNA, Complementary; D005260:Female; D006801:Humans; D017403:In Situ Hybridization; D051379:Mice; D008969:Molecular Sequence Data; D017386:Sequence Homology, Amino Acid; D014960:X Chromosome
D018528:ATP-Binding Cassette Transporters; D018076:DNA, Complementary