title: Uterine rupture during induction of labor at term with intravaginal misoprostol.
abstract: BACKGROUND
  Misoprostol (prostaglandin E1) compares favorably with dinoprostone (prostaglandin E2) and oxytocin for labor induction at term. Excessive uterine activity has been reported using high-dose regimens, but no negative effect on outcomes has been observed.
  
  
  METHODS
  Labor was induced in a 34-year-old multipara at 39 weeks' gestation using intravaginal misoprostol tablets. Five hours after administration of the second 25-microgram dose, fetal bradycardia prompted emergency cesarean delivery. Hysterectomy and left salpingo-oophorectomy were necessary to control bleeding from a 15-cm posterior uterine wall rupture.
  
  
  CONCLUSIONS
  Misoprostol can cause excessive uterine activity and uterine rupture.
authors.affiliation: Department of Obstetrics and Gynecology, University of Florida College of Medicine, Gainesville, USA.
authors.forename: B B
authors.initials: BB
authors.lastname: Bennett
mesh_terms: D000282:Administration, Intravaginal; D000328:Adult; D002585:Cesarean Section; D004630:Emergencies; D005260:Female; D005316:Fetal Distress / Q000139:chemically induced; D006801:Humans; D007044:Hysterectomy; D007751:Labor, Induced / Q000009:adverse effects*; D016595:Misoprostol / Q000009:adverse effects*; D010052:Ovariectomy; D010120:Oxytocics / Q000009:adverse effects*; D011247:Pregnancy; D011263:Pregnancy Trimester, Third; D014597:Uterine Rupture / Q000139:chemically induced* / Q000601:surgery
chemical_list: D010120:Oxytocics; D016595:Misoprostol