MDMA and d-amphetamine produce comparable effects in pigeons performing under a multiple fixed-ratio interresponse-time-greater-than-t schedule of food delivery.
The purpose of this study was to gain further information about the behavioral effects of (+/-) 3.4-methylenedioxymethamphetamine (MDMA) on schedule-controlled responding. MDMA (0.32, 0.56, 1.0, 3.2, 5.6, and 10 mg/kg) and d-amphetamine (0.32, 0.56, 1.0, 3.2, 5.6, and 10 mg/kg) were administered to pigeons performing under a multiple fixed-ratio 30 (FR 30) interresponse-time-greater-than-15-s (IRT > 15-s) schedule of food delivery. In general, both drugs had no significant effect on response rates under the IRT > 15-s component at doses that decreased rates under the FR component. Results of the present experiment indicate that under some conditions MDMA and d-amphetamine produce similar, and rate-dependent, effects.
LeSage
M
M
Department of Psychology, Western Michigan University, Kalamazoo 49008, USA.
Poling
A
A
D000818:Animals; D000697:Central Nervous System Stimulants / Q000494:pharmacology*; D010856:Columbidae; D003216:Conditioning, Operant / Q000187:drug effects*; D003913:Dextroamphetamine / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D005502:Food; D006213:Hallucinogens / Q000494:pharmacology*; D018817:N-Methyl-3,4-methylenedioxyamphetamine / Q000494:pharmacology*; D011930:Reaction Time / Q000187:drug effects; D012055:Reinforcement Schedule
D000697:Central Nervous System Stimulants; D006213:Hallucinogens; D018817:N-Methyl-3,4-methylenedioxyamphetamine; D003913:Dextroamphetamine