title: Sensitivity and specificity of OraScan (R) toluidine blue mouthrinse in the detection of oral cancer and precancer.
abstract: The efficacy of 1% toluidine blue in the identification of oral malignancies and potentially malignant oral lesions was evaluated among a group of Asian patients (n = 102) with undiagnosed oral mucosal lesions and conditions (n = 145). The trial, utilising a ready-to-use kit, was controlled by histopathologic evaluation of a total of 87 dye-retained or dye-negative lesions. Eighteen oral carcinomas all retained the dye and there were no false negatives, yielding a test sensitivity of 100%. Eight of 39 oral epithelial dysplasias were toluidine blue-negative, giving a false negative rate of 20.5% and a sensitivity of 79.5% for oral epithelial dysplasias. The specificity of the technique was low (62%). Five dysplastic lesions were detected solely by the kit and this suggests that the method is valuable for surveillance of high-risk subjects in addition to its remarkable sensitivity in the detection of invasive carcinoma.
authors.affiliation: RCS Department of Dental Sciences and Department of Oral Medicine and Pathology, King's College School of Medicine and Dentistry, London, England.
authors.forename: K A
authors.initials: KA
authors.lastname: Warnakulasuriya
authors.forename: N W
authors.initials: NW
authors.lastname: Johnson
mesh_terms: D001208:Asia / Q000208:ethnology; D002277:Carcinoma / Q000175:diagnosis / Q000473:pathology; D004396:Coloring Agents; D004848:Epithelium / Q000473:pathology; D004919:Erythroplasia / Q000175:diagnosis / Q000473:pathology; D005188:False Negative Reactions; D005260:Female; D006801:Humans; D007972:Leukoplakia, Oral / Q000175:diagnosis / Q000473:pathology; D017676:Lichen Planus, Oral / Q000175:diagnosis / Q000473:pathology; D008131:London; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa / Q000473:pathology; D009062:Mouth Neoplasms / Q000175:diagnosis* / Q000473:pathology; D009067:Mouthwashes; D009361:Neoplasm Invasiveness; D009914:Oral Submucous Fibrosis / Q000175:diagnosis / Q000473:pathology; D019226:Oral Ulcer / Q000175:diagnosis / Q000473:pathology; D011159:Population Surveillance; D011230:Precancerous Conditions / Q000175:diagnosis* / Q000473:pathology; D011933:Reagent Kits, Diagnostic; D012307:Risk Factors; D012680:Sensitivity and Specificity; D014048:Tolonium Chloride
chemical_list: D004396:Coloring Agents; D009067:Mouthwashes; D011933:Reagent Kits, Diagnostic; D014048:Tolonium Chloride