Adherence of Helicobacter pylori to the gastric mucosa.
Bacterial adhesion to the intestinal epithelium is a critical initial step in the pathogenesis of many enteric diseases. Helicobacter pylori is a duodenal pathogen that adheres to the gastric epithelium and causes gastritis and peptic ulceration. The mechanism by which H pylori causes disease has not been elucidated but adherence to the gastric mucosa is thought to be an important virulence determinant of the organism. What is known about adherence of H pylori to the gastric mucosa is summarized. Topics discussed are the mechanism of H pylori adherence; in vitro and in vivo models of H pylori infection; and adherence and potential adhesins and receptors for H pylori.
Clyne
M
M
Department of Paediatrics, University College Dublin, Children's Research Centre, Our Lady's Hospital for Sick Children, Crumlin, Ireland. marg@crumlin.ucd.ie
Drumm
B
B
D018829:Adhesins, Bacterial / Q000032:analysis / Q000378:metabolism*; D000818:Animals; D001422:Bacterial Adhesion / Q000502:physiology*; D004195:Disease Models, Animal; D005753:Gastric Mucosa / Q000201:enzymology / Q000382:microbiology*; D006168:Guinea Pigs; D016481:Helicobacter Infections / Q000201:enzymology / Q000503:physiopathology*; D016480:Helicobacter pylori / Q000472:pathogenicity / Q000502:physiology*; D006801:Humans; D051379:Mice; D011817:Rabbits; D051381:Rats
D018829:Adhesins, Bacterial