A live-virus "suicide" vaccine for human immunodeficiency virus.
A vaccine that uses a live, attenuated human immunodeficiency virus (HIV) may offer the best hope of a vaccine against acquired immunodeficiency syndrome (AIDS). A recent improvement should increase the safety of the live-virus approach: a "suicide gene" inserted into the viral RNA, which causes infected cells to die when treated with ganciclovir. We envision using this strategy not only to prevent AIDS, but also to treat it.
Kestler
H W
HW
Department of Molecular Biology, Cleveland Clinic, Cleveland Clinic Foundation, OH 44195, USA.
Chakrabarti
B K
BK
D016915:AIDS Vaccines / Q000276:immunology* / Q000627:therapeutic use*; D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy* / Q000517:prevention & control*; D019380:Anti-HIV Agents / Q000627:therapeutic use; D003131:Combined Modality Therapy; D015774:Ganciclovir / Q000627:therapeutic use; D015754:Genes, nef; D015497:HIV-1 / Q000235:genetics; D006801:Humans; D014613:Vaccines, Attenuated / Q000276:immunology
D016915:AIDS Vaccines; D019380:Anti-HIV Agents; D014613:Vaccines, Attenuated; D015774:Ganciclovir