A subset of senile dementia with high incidence of the apolipoprotein E epsilon2 allele.
There is a subset of very elderly patients with senile dementia in whom abundant neurofibrillary tangles are present, mainly in the hippocampal region, without a significant number of senile plaques. In a retrospective neuropathological examination of 239 dementia patients, 14 were found to have this type of senile dementia. The apolipoprotein E epsilon2, epsilon3, and epsilon4 allele frequencies in this patient group were 0.39, 0.50, and 0.11, respectively. Such a high frequency of the epsilon2 allele suggests that this type of dementia is distinct from Alzheimer's disease not only from a neuropathological but also from a genetic viewpoint.
Ikeda
K
K
Department of Neuropathology, Tokyo Institute of Psychiatry, Setagaya-ku, Japan.
Akiyama
H
H
Arai
T
T
Sahara
N
N
Mori
H
H
Usami
M
M
Sakata
M
M
Mizutani
T
T
Wakabayashi
K
K
Takahashi
H
H
D000368:Aged; D000369:Aged, 80 and over; D053329:Apolipoprotein E2; D001057:Apolipoproteins E / Q000235:genetics*; D003704:Dementia / Q000235:genetics* / Q000473:pathology*; D005787:Gene Frequency; D005838:Genotype; D005911:Gliosis; D006624:Hippocampus / Q000473:pathology; D006801:Humans; D016874:Neurofibrillary Tangles / Q000473:pathology*; D012189:Retrospective Studies
D053329:Apolipoprotein E2; D001057:Apolipoproteins E