Protection of mice from fatal bubonic and pneumonic plague by passive immunization with monoclonal antibodies against the F1 protein of Yersinia pestis.
Monoclonal antibodies (MAbs) to the fraction 1 (F1) protein of Yersinia pestis protected mice against fatal pneumonic as well as bubonic plague from wild-type F1+ organisms. The rare isolation of a virulent F1- isolate from surviving animals supports earlier studies suggesting that improved vaccines should consist of immunogens to protect against F1- variants. The high degree of protection with IgG MAb suggests that secretory IgA is not required for protection from pneumonic plague.
Anderson
G W
GW
U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland 21702-5011, USA.
Worsham
P L
PL
Bolt
C R
CR
Andrews
G P
GP
Welkos
S L
SL
Friedlander
A M
AM
Burans
J P
JP
D000818:Animals; D000911:Antibodies, Monoclonal / Q000008:administration & dosage / Q000627:therapeutic use*; D000914:Antibodies, Viral / Q000097:blood; D001426:Bacterial Proteins / Q000276:immunology*; D004306:Dose-Response Relationship, Immunologic; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D007116:Immunization, Passive; D007274:Injections, Intraperitoneal; D051379:Mice; D010930:Plague / Q000517:prevention & control*; D015010:Yersinia pestis / Q000276:immunology*
D000911:Antibodies, Monoclonal; D000914:Antibodies, Viral; D001426:Bacterial Proteins