A clinical comparison of typhoid fever caused by susceptible and multidrug-resistant strains of Salmonella typhi.
The clinical features and response to therapy with ciprofloxacin were studied in two groups of patients: those infected by susceptible strains of Salmonella typhi and others infected by multidrug-resistant strains. There was no significant difference in the clinical presentation, laboratory findings and outcome between the two groups. Patients infected with multidrug-resistant strains, however, defervesced in significantly longer time (5.5 days) than those infected by susceptible strains (4.35 days) (p = 0.031). In areas with high prevalence of multidrug-resistant Salmonella infection, empiric treatment with quinolones or third-generation cephalosporins of all patients with suspected typhoid fever until the results of culture sensitivity tests are available may lead to better outcome.
Alsoub
H
H
Department of Medicine, Hamad Medical Corporation, Doha, Qatar.
Uwaydah
A K
AK
Matar
I
I
Zebeib
M
M
Elhag
K M
KM
D000293:Adolescent; D000328:Adult; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D016470:Bacteremia / Q000188:drug therapy* / Q000382:microbiology; D002939:Ciprofloxacin / Q000627:therapeutic use*; D004352:Drug Resistance, Microbial; D018432:Drug Resistance, Multiple; D005260:Female; D006801:Humans; D008297:Male; D012485:Salmonella typhi / Q000187:drug effects*; D016896:Treatment Outcome; D014435:Typhoid Fever / Q000150:complications* / Q000382:microbiology
D000890:Anti-Infective Agents; D002939:Ciprofloxacin