Altered calcium homeostasis in the rat cochlear duct and endogenous corticosteroid insufficiency.
Free calcium concentration (CCa2+) profiles were evaluated in perilymph, endolymph, marginal cells, spiral ligament and blood serum of adrenalectomized (ADX) rats. Free CCa2+ was significantly greater in perilymph and significantly reduced in the serum of the ADX animals as compared to sham-operated animals. In addition, higher levels of free CCa2+ were found in the spiral ligament in ADX animals. Free CCa2+ did not appear to be affected by ADX in marginal cells and endolymph. These data suggest that marked reductions in endogenous levels of corticosteroids may have a systematic effect on free CCa2+ that is detectable in blood serum as well as cochlear fluids and tissues.
Ma
Y L
YL
Department of Anatomy and Cell Biology, University of Florida, Gainesville 32610, USA.
Rarey
K E
KE
Gerhardt
K J
KJ
Garg
L C
LC
Rybak
L P
LP
D000305:Adrenal Cortex Hormones / Q000502:physiology*; D000315:Adrenalectomy; D000818:Animals; D002118:Calcium / Q000502:physiology*; D015220:Calcium Channels / Q000502:physiology*; D002199:Capillary Permeability / Q000502:physiology; D003053:Cochlear Duct / Q000502:physiology*; D004710:Endolymph / Q000502:physiology; D008564:Membrane Potentials / Q000502:physiology; D008839:Microelectrodes; D010498:Perilymph / Q000502:physiology; D051381:Rats
D000305:Adrenal Cortex Hormones; D015220:Calcium Channels; D002118:Calcium