Metabotropic glutamate receptor subtype-1 alpha (mGluR1 alpha) immunoreactivity in ependymal cells of the rat caudal medulla oblongata and spinal cord.
Immunohistochemical study of the distribution of glutamate receptor subunits 1-4 (GluR1-4), NMDA receptor subunit 1 and metabotropic glutamate receptor subtypes 1-3 (mGluR1-3) in the ependymal cells of the caudal medulla oblongata and upper thoracic spinal cord was carried out. The results showed that ependymal cells and tanycytes expressed only the metabotropic receptor subtype, mGluR1 alpha. Some of the mGluR1 alpha-positive long basal processes of the tanycytes reached the pia mater; some made contact with capillaries. It was suggested that the activity of the these mGluR 1 a-positive tanycytes may be regulated by the CSF and blood. The presence of many mGluR1 alpha positive fibres in the area postrema suggests that mGluR1 alpha subtype in this region may be involved in cardiovascular regulation.
Tang
F R
FR
Department of Pharmacology, Faculty of Medicine, National University of Singapore, Singapore.
Sim
M K
MK
D000818:Animals; D004805:Ependyma / Q000378:metabolism*; D007150:Immunohistochemistry; D008297:Male; D008526:Medulla Oblongata / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D018094:Receptors, Metabotropic Glutamate / Q000276:immunology*; D013116:Spinal Cord / Q000378:metabolism*
D018094:Receptors, Metabotropic Glutamate