Analysis of the myoglobin gene in heart disease.
Analysis of the myoglobin gene from a large number of patients with cardiac disease disclosed a single substantive mutation. However, no evidence of biochemical or physiological dysfunction due to this mutation was detected. We conclude that, within the limits of presently available techniques, myoglobin mutations are unlikely to contribute substantially to the genotypic background of cardiac disease in the general population.
Fernandez
E
E
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235-8573, USA.
Duke
A
A
Sevrioukova
I
I
Shohet
R V
RV
D002248:Carbon Monoxide / Q000378:metabolism; D006328:Cardiac Catheterization; D003461:Crystallography; D005838:Genotype; D006331:Heart Diseases / Q000235:genetics*; D006801:Humans; D009211:Myoglobin / Q000235:genetics* / Q000378:metabolism; D018807:Polymorphism, Single-Stranded Conformational
D009211:Myoglobin; D002248:Carbon Monoxide