title: The ovine SOX2 gene: sequence, chromosomal localization and gonadal expression.
abstract: The SOX gene family consists of a large number of embryonically expressed genes capable of encoding putative transcription factors and related by a DNA-binding domain, the HMG-box. We cloned and characterized the ovine SOX2 transcript using the screening of a testis (12dpp) cDNA library with a probe containing the SRY-HMG-box and we performed 3'RACE experiments. The ovine SOX2 sequence is strongly conserved in comparison to the human, mouse and chicken homologues and is located on sheep chromosome 1q33. The SOX2 expression pattern in developing gonads is consistent with the hypothesis that this gene plays a role in the germ cell line.
authors.affiliation: Laboratoire de Biologie Cellulaire et Moléculaire, INRA, Batiment des Biotechnologies, Jouy en Josas, France.
authors.forename: E
authors.initials: E
authors.lastname: Payen
authors.forename: E
authors.initials: E
authors.lastname: Pailhoux
authors.forename: L
authors.initials: L
authors.lastname: Gianquinto
authors.forename: H
authors.initials: H
authors.lastname: Hayes
authors.forename: N
authors.initials: N
authors.lastname: Le Pennec
authors.forename: J
authors.initials: J
authors.lastname: Bezard
authors.forename: C
authors.initials: C
authors.lastname: Cotinot
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping; D003001:Cloning, Molecular; D004268:DNA-Binding Proteins / Q000737:chemistry / Q000235:genetics*; D018507:Gene Expression Regulation, Developmental; D005796:Genes; D006066:Gonads / Q000378:metabolism*; D024002:HMGB Proteins; D008297:Male; D008969:Molecular Sequence Data; D009687:Nuclear Proteins / Q000737:chemistry / Q000235:genetics*; D055748:SOXB1 Transcription Factors; D012756:Sheep; D013737:Testis / Q000378:metabolism; D014157:Transcription Factors
chemical_list: D004268:DNA-Binding Proteins; D024002:HMGB Proteins; D009687:Nuclear Proteins; C527782:SOX2 protein, human; D055748:SOXB1 Transcription Factors; C527783:Sox2 protein, mouse; D014157:Transcription Factors