title: Case report: primary hepatic lymphoma associated with chronic liver disease.
abstract: We report on a case of primary hepatic lymphoma that developed in a patient with chronic hepatitis C. Given that Japan is an area endemic for both hepatitis B and C viruses, we reviewed 51 Japanese cases of primary hepatic lymphoma, addressing the question as to whether the Japanese cases have unique characteristics and whether there is a causal relationship to the presence of chronic liver disease. Primary hepatic lymphoma most commonly affected middle-aged males. Presenting symptoms and physical findings were non-specific. Aminotransferases tended to stay in the low range compared with marked increases in lactate dehydrogenase. Sixteen patients (31%) had chronic liver disease, eight had liver cirrhosis and eight had chronic hepatitis, suggesting that there is a possible aetiological link between chronic liver disease and primary hepatic lymphoma.
authors.affiliation: Division of Hematology, Showa University Fujigaoka Hospital, Yokohama, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Higuchi
authors.forename: K
authors.initials: K
authors.lastname: Nomoto
authors.forename: H
authors.initials: H
authors.lastname: Mori
authors.forename: H
authors.initials: H
authors.lastname: Niikura
authors.forename: M
authors.initials: M
authors.lastname: Omine
authors.forename: K
authors.initials: K
authors.lastname: Sekiyama
authors.forename: M
authors.initials: M
authors.lastname: Yoshiba
authors.forename: R
authors.initials: R
authors.lastname: Fujita
mesh_terms: D000328:Adult; D006526:Hepatitis C / Q000150:complications*; D006521:Hepatitis, Chronic / Q000150:complications*; D006801:Humans; D008113:Liver Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D008223:Lymphoma / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D008228:Lymphoma, Non-Hodgkin / Q000150:complications / Q000175:diagnosis / Q000473:pathology; D008297:Male; D014057:Tomography, X-Ray Computed