Altered expression of class I major histocompatibility antigens on bovine cells infected with the protozoan parasite Theileria annulata.
Theileria annulata infection is controlled by MHC class I restricted cytotoxic T cell killing of infected cells. The long term persistence of parasite suggests that it employs a mechanism to avoid immune surveillance. In this paper we describe the modification of BoLA class I antigens on the surface of Theileria annulata transformed lymphoblastoid cells. The extent of modification is different between individuals varying from extensive to undetectable.
Oliver
R A
RA
The Roslin Institute, Midlothian, UK.
Williams
J L
JL
D000818:Animals; D002417:Cattle; D015395:Histocompatibility Antigens Class I / Q000302:isolation & purification / Q000378:metabolism*; D000949:Histocompatibility Antigens Class II / Q000378:metabolism; D066298:In Vitro Techniques; D007525:Isoelectric Focusing; D007963:Leukocytes, Mononuclear / Q000276:immunology / Q000469:parasitology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology / Q000469:parasitology; D016796:Theileria annulata / Q000276:immunology*; D013801:Theileriasis / Q000276:immunology* / Q000469:parasitology
D015395:Histocompatibility Antigens Class I; D000949:Histocompatibility Antigens Class II