[The immunobiological properties of trimezon and levamisole on models of humoral and cell-mediated immunogenesis].
It was shown in mice experiments that intragastric administration of the low-molecular synthetic immunomodulator of the 8-azasteroid series trimesone increases the immune response of humoral and cell-mediated types to the thymus-dependent antigen, the sheep erythrocytes. The stimulating effect of the drug in vivo is determined by the dose, the antigen load, and the animals' genotype and does not yield to the effect of levamisole or exceeds it in identical experimental conditions.
Liubin
G S
GS
Kuz'mitskiĭ
B B
BB
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D001372:Aza Compounds / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005838:Genotype; D007111:Immunity, Cellular / Q000187:drug effects*; D007114:Immunization; D007978:Levamisole / Q000494:pharmacology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D013268:Stimulation, Chemical
D000276:Adjuvants, Immunologic; D001372:Aza Compounds; C087739:trimezon; D007978:Levamisole
Immunobiologicheskie svoĭstva trimezona i levamizola na modeliakh gumoral'nogo i kletochnooposredovannogo immunogeneza.