The role of Helicobacter pylori infection in non-ulcer dyspepsia.
It is currently unclear whether Helicobacter pylori (H. pylori) infection plays a role in patients who fulfil the criteria for non-ulcer dyspepsia. This paper reviews evidence for H. pylori-induced changes in gastric emptying, gastrointestinal motility, gastric acid secretion, and gastric perception in patients with non-ulcer dyspepsia. Problems in study design and execution of non-ulcer dyspepsia treatment trials are discussed. The results of non-ulcer dyspepsia treatment trials which have been performed in H. pylori-positive patients are reviewed. To date none of them has convincingly shown that cure of the H. pylori infection leads to a sustained improvement in symptoms.
Veldhuyzen van Zanten
S J
SJ
Division of Gastroenterology (1), Dalhousie University, Queen Elizabeth II Hospital, Halifax, Nova Scotia, Canada.
D000897:Anti-Ulcer Agents / Q000627:therapeutic use; D004415:Dyspepsia / Q000188:drug therapy / Q000382:microbiology* / Q000503:physiopathology; D005500:Follow-Up Studies; D005744:Gastric Acid / Q000378:metabolism; D005746:Gastric Emptying / Q000502:physiology; D005769:Gastrointestinal Motility / Q000502:physiology; D016481:Helicobacter Infections / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology*; D016480:Helicobacter pylori / Q000502:physiology*; D006801:Humans; D012107:Research Design; D016896:Treatment Outcome
D000897:Anti-Ulcer Agents