title: [Total parathyroidectomy and autotransplantation of parathyroid tissue. Functional assessment of the autograft 5-10 years after surgery with the help of local ischemic blockade].
abstract: The aim of the present study was to assess the long-term function of autotransplanted parathyroid tissue. From the medical records of a consecutive series of 21 patients we found that during the time of follow-up (79 months) one patient developed parathyroid graft dependent recurrent hyperparathyroidism (HPT) and one patient suffered from hypoparathyroidism. Nine of the patients were available for measurements of the plasma concentrations of intact parathyroid hormone (iPTH) at rest and during a shortlasting ischaemic blockade of the autotransplant. In eight patients, the ischaemic blockade reduced the concentration of iPTH with on average 62% as compared to baseline values. In one patient, the autotransplant had been resected and as expected, iPTH did not change during ischaemic blockade. Our results indicate that total parathyroidectomy with autotransplantation provides a rational alternative to the surgical treatment of secondary HPT and that the ischaemic blockade manoeuvre seems suitable for assessment of the function of parathyroid autotransplants.
authors.affiliation: Nefrologisk Afdeling P, Rigshospitalet.
authors.forename: L
authors.initials: L
authors.lastname: Knudsen
authors.forename: L
authors.initials: L
authors.lastname: Brandi
authors.forename: H
authors.initials: H
authors.lastname: Daugaard
authors.forename: K
authors.initials: K
authors.lastname: Lockwood
authors.forename: K
authors.initials: K
authors.lastname: Olgaard
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006961:Hyperparathyroidism / Q000503:physiopathology / Q000601:surgery*; D007011:Hypoparathyroidism / Q000503:physiopathology / Q000601:surgery*; D007511:Ischemia; D008297:Male; D008875:Middle Aged; D010280:Parathyroid Glands / Q000098:blood supply / Q000503:physiopathology / Q000637:transplantation*; D010281:Parathyroid Hormone / Q000097:blood; D016105:Parathyroidectomy / Q000379:methods*; D014182:Transplantation, Autologous
chemical_list: D010281:Parathyroid Hormone
vernacular_title: Total paratyreoidektomi og autotransplantation af parathyreoideavaev. Vurdering af autotransplantatets funktion 5-10 år efter operationen ved hjoelp af lokal iskoemisk blokade.