[Influence on extratumoral organ activities of tumor-affinity samarium-153 preparations].
OBJECTIVE
Possibilities to exercise an influence on the biodistribution of a tumor-affine 153Sm-preparation, samarium-153-nitrilotriacetate (NTA), were tested.


METHODS
Animals experiments on tumor-bearing mice after additional application of EDTMP (ethylenediamine tetramethylene phosphonate) for the reduction of extratumorale liver-radioactivity and yttrium chloride for the reduction of unwanted underground radioactivity in bone were carried out. Furthermore, the combination of both measurements was tested.


RESULTS
The biodistribution of 153Sm-NTA showed a rather low tumor-radioactivity of app. 0.72%/g. The additional EDTMP-application caused a dose-dependent decrease of the underground-radioactivity in liver especially if given 2 h in advance or simultaneously. The additional application of the stable yttrium salt reduced the bone radioactivity on simultaneous increase of liver- and spleen-radioactivity and practically unchanged tumor-radioactivity. The combined use of EDTMP together with the bone-affine metal salt led to a reduction of liver radioactivity on simultaneous reduction of bone radioactivity.


CONCLUSIONS
The background radioactivity can be reduced on unchanged tumor-radioactivity by combined Na-EDTMP/YCl3-application. The present results do not allow a therapeutic exploitation because of the low tumor accumulation.
Schomäcker
K
K
Klinik und Poliklinik für Nuklearmedizin, Universität zu Köln, Deutschland.
Hebrank
H
H
Scheidhauer
K
K
Scharl
A
A
Saccavini
J C
JC
Shukla
S K
SK
Franke
W G
WG
Schicha
H
H
D000818:Animals; D002277:Carcinoma / Q000000981:diagnostic imaging*; D002614:Chelating Agents / Q000494:pharmacology; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA; D009571:Nitrilotriacetic Acid / Q000493:pharmacokinetics / Q000494:pharmacology*; D009943:Organophosphorus Compounds / Q000494:pharmacology; D011868:Radioisotopes; D011877:Radionuclide Imaging; D012493:Samarium / Q000493:pharmacokinetics / Q000494:pharmacology*; D014018:Tissue Distribution; D015019:Yttrium / Q000494:pharmacology
D002614:Chelating Agents; D009943:Organophosphorus Compounds; D011868:Radioisotopes; C064782:yttrium chloride; C018940:(ethylenedinitrilo)-tetramethylenephosphonic acid; D012493:Samarium; D015019:Yttrium; D009571:Nitrilotriacetic Acid
Beeinflussung extratumoraler Organaktivitäten von tumoraffinen Samarium-153-Zubereitungen.