title: [Serum TSH values during clinical controls of patients treated for congenital hypothyroidism].
abstract: During the second half of 1995, an increased serum TSH level was found in about 50% of the patients that had been biochemically studied to check their treatment for hypothyroidism by the Laboratory of Molecular Endocrinology in the Regional Hospital of Malaga. A retrospective analysis was carried out to check if those results were erroneous. The biochemical data concerning the thyroid function were followed-up in patients requiring more studies, such as the ones suffering from congenital hypothyroidism (CH) and a random double assay of some samples was made with an alternative technique. Currently, the average TSH level is rated as 14.31 microU/ml in 54% of the subjects, even though levothyroxine doses were increased. Levothroid is the preparation prescribed in all cases. In 1994, the TSH average level was 1.68 microU/ml in the aforementioned group. Another 12% with increased TSH levels were readjusted by modifying the treatment. The T4F in CH subjects with increased TSH dropped significantly from 24.1 pmol/ml to 15.7 pmol/ml in the same period of time. We suggest that one possible etiological factor could be a mistake in the dosage of the commercial preparation.
authors.affiliation: Laboratorio de Endocrinología Molecular, Hospital Regional, Málaga.
authors.forename: S
authors.initials: S
authors.lastname: Perán Mesa
authors.forename: M J
authors.initials: MJ
authors.lastname: Gariga Cascón
authors.forename: J P
authors.initials: JP
authors.lastname: López Siguero
authors.forename: M
authors.initials: M
authors.lastname: Perán Quesada
mesh_terms: D000328:Adult; D003409:Congenital Hypothyroidism; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007037:Hypothyroidism / Q000097:blood* / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D011897:Random Allocation; D012189:Retrospective Studies; D013963:Thyroid Hormones / Q000627:therapeutic use; D013972:Thyrotropin / Q000097:blood*
chemical_list: D013963:Thyroid Hormones; D013972:Thyrotropin
vernacular_title: Valores elevados de TSH en los controles de tratamiento del hipotiroidismo congénito.