title: Characterisation of atherosclerotic plaque by spectral analysis of intravascular ultrasound: an in vitro methodology.
abstract: Raw 30-MHz intravascular ultrasound data have been captured from postmortem coronary arteries (n = 4) to develop radio frequency analysis techniques for the characterisation of atherosclerotic plaque. Digitised data acquired from positions (n = 8) within diseased sections of artery were compared with the corresponding histology and radiology. Scan-converted images were used to locate regions of interest (ROI = 33) within areas of tissue composition: loose fibrotic tissue (LFT), dense fibrotic tissue (DFT) and calcium (CA). A range of parameters was extracted from the normalised power spectrum of each ROI within the bandwidth 17-42 MHz. Significant discrimination between LFT/DFT and between LFT/CA was provided by maximum power and spectral slope (dBMHz-1). However, the greatest discriminative power was given by the y-axis (0 Hz) intercept of the spectral slope: LFT/DFT (p = 0.001); LFT/CA (p = 0.0001); and DFT/CA (p = 0.089).
authors.affiliation: Department of Medical Physics, Edinburgh University, Western General Hospital, Scotland, UK. timsp@tattoo.ed.ac.uk
authors.forename: T
authors.initials: T
authors.lastname: Spencer
authors.forename: M P
authors.initials: MP
authors.lastname: Ramo
authors.forename: D M
authors.initials: DM
authors.lastname: Salter
authors.forename: T
authors.initials: T
authors.lastname: Anderson
authors.forename: P P
authors.initials: PP
authors.lastname: Kearney
authors.forename: G R
authors.initials: GR
authors.lastname: Sutherland
authors.forename: K A
authors.initials: KA
authors.lastname: Fox
authors.forename: W N
authors.initials: WN
authors.lastname: McDicken
mesh_terms: D003324:Coronary Artery Disease / Q000000981:diagnostic imaging* / Q000473:pathology; D003331:Coronary Vessels / Q000000981:diagnostic imaging* / Q000473:pathology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D066298:In Vitro Techniques; D012815:Signal Processing, Computer-Assisted; D018084:Ultrasonography, Interventional