[The mechanism of the anti-arrhythmia action of mu-opioid-receptor agonists in a model of CaCl2-induced arrhythmias: the role of the autonomic nervous system].
It was established that selective ligands of the mu-opioid receptors DAGO and DALDA exhibit antiarrhythmic activity on a model of CACl2-induced arrhythmias when infused intravenously in a dose of 0.2 mg/kg. The autonomic nervous system does not take part in realization of the antiarrhythmic effect of DAGO and DALDA. It is supposed that this effect of DAGO and DALDA is associated with activation of cardiac mu-opioid receptors.
Maslov
L N
LN
Lishmanov
Iu B
IuB
Krylatov
A V
AV
Ugdyzhekova
D S
DS
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000188:drug therapy* / Q000503:physiopathology; D001285:Atropine / Q000494:pharmacology; D001341:Autonomic Nervous System / Q000187:drug effects / Q000502:physiology*; D002122:Calcium Chloride; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D020875:Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; D004745:Enkephalins / Q000627:therapeutic use*; D005730:Ganglionic Blockers / Q000494:pharmacology; D018738:Hexamethonium / Q000494:pharmacology; D008297:Male; D009842:Oligopeptides / Q000627:therapeutic use*; D010276:Parasympatholytics / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D017450:Receptors, Opioid, mu / Q000819:agonists* / Q000502:physiology
D000889:Anti-Arrhythmia Agents; D004745:Enkephalins; D005730:Ganglionic Blockers; D009842:Oligopeptides; D010276:Parasympatholytics; D017450:Receptors, Opioid, mu; D020875:Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; C063076:tyrosyl-arginyl-phenylalanyl-lysinamide; D018738:Hexamethonium; D001285:Atropine; D002122:Calcium Chloride
Mekhanizm antiaritmicheskogo deĭstviia agonistov mu-opiatnykh retseptorov na modeli CaCl2-indutsirovannykh aritmiĭ: rol' vegetativnoĭ nervnoĭ sistemy.