title: Relapse of intracranial germinoma 23 years postirradiation in a patient given growth hormone replacement.
abstract: There is no clear evidence that growth hormone replacement therapy for treatment-related growth hormone deficiency in patients with childhood intracranial malignancies has a role in tumour relapse or second malignancy. A 16-year-old girl with an intracranial germinoma was treated with local radiotherapy and subsequently received growth hormone replacement therapy as an adult. Three years after starting growth hormone therapy, 23 years after her radiotherapy treatment, the patient's tumour recurred. Surveillance requirements for patients receiving growth hormone in this setting are discussed.
authors.affiliation: Department of Clinical Oncology, Christie Hospital NHS Trust, Manchester, United Kingdom.
authors.forename: A E
authors.initials: AE
authors.lastname: Kiltie
authors.forename: C D
authors.initials: CD
authors.lastname: Collins
authors.forename: H R
authors.initials: HR
authors.lastname: Gattamaneni
authors.forename: S M
authors.initials: SM
authors.lastname: Shalet
mesh_terms: D000293:Adolescent; D000328:Adult; D001932:Brain Neoplasms / Q000139:chemically induced* / Q000532:radiotherapy* / Q000601:surgery; D017809:Fatal Outcome; D005260:Female; D018237:Germinoma / Q000139:chemically induced* / Q000532:radiotherapy* / Q000601:surgery; D013006:Growth Hormone / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D007018:Hypopituitarism / Q000188:drug therapy* / Q000209:etiology; D009364:Neoplasm Recurrence, Local / Q000139:chemically induced*; D018714:Radiotherapy, Adjuvant; D012658:Sella Turcica
chemical_list: D013006:Growth Hormone