Thyroid and adrenal function in HIV-infected outpatients.
We investigated parameters of thyroid and endocrine functions in 100 HIV-infected men who were grouped according to the CDC criteria. Progression of the disease was associated with a 44% increase in plasma TBG and a 15% increase in plasma CBG, while the T4/TBG ratio was decreased by 20%, plasma DHEAS was lowered by 30% and urinary aldosterone excretion fell by 70%. Plasma T4, T3 and TSH and urinary excretion of cortisol and catecholamines was not influenced by the disease. A weak, but significant negative correlation was found between plasma CBG and the body mass index of the patients. Significant positive correlations were observed between CD-4 cell count and the T4/TBG-ratio or plasma DHEAS levels. TBG was inversely correlated with CD-4 cell count and DHEAS. Thus, an increase in plasma TBG and a shift from adrenal androgen and mineralocorticoid steroid secretion towards cortisol secretion may be endocrine markers for progression of the disease in patients with HIV-infection.
Schürmeyer
T H
TH
Department Endocrinology and Metabolism, FPP, Trier University, Germany.
Müller
V
V
von zur Mühlen
A
A
Schmidt
R E
RE
D000311:Adrenal Glands / Q000503:physiopathology*; D000328:Adult; D004298:Dopamine / Q000652:urine; D004837:Epinephrine / Q000652:urine; D015658:HIV Infections / Q000503:physiopathology*; D006801:Humans; D006854:Hydrocortisone / Q000652:urine; D008297:Male; D009638:Norepinephrine / Q000652:urine; D013961:Thyroid Gland / Q000503:physiopathology*; D013963:Thyroid Hormones / Q000097:blood
D013963:Thyroid Hormones; D004298:Dopamine; D006854:Hydrocortisone; D009638:Norepinephrine; D004837:Epinephrine