[Reduction of endothelial cell number by cataract operation with intraocular thymoxamine administration. A randomized, double-blind study].
BACKGROUND
Thymoxamine, an alpha-1-receptor blocker, considerably enhances miosis when given intraocularly in combination with acetylcholine. We investigated whether intraocular use of thymoxamine 0.02% reduced the number of endothelial cells.


METHODS
After phacoemulsification of 59 eyes, either thymoxamine 0.02%, acetylcholine 1.0% or buffered saline solution was given intraocularly. With a contact specular microscope, corneal endothelial cell photographs were taken on the day before treatment and 3 days and 6 weeks after surgery.


RESULTS
There were no statistically significant differences between endothelial cell counts of eyes treated with thymoxamine (-7.2%), acetylcholine (-10.2%) or BSS (-9.4%).


CONCLUSIONS
This study shows for the first time that thymoxamine, when given in the anterior chamber after phacoemulsification, does not cause a greater loss of endothelial cells than acetylcholine or buffered saline solution.
Schwenn
O K
OK
Universitäts-Augenklinik, Mainz.
Schellein
O
O
Pfeiffer
N
N
Grehn
F
F
D000109:Acetylcholine / Q000008:administration & dosage / Q000009:adverse effects; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002452:Cell Count / Q000187:drug effects; D004311:Double-Blind Method; D004728:Endothelium, Corneal / Q000187:drug effects*; D005260:Female; D006801:Humans; D007910:Lenses, Intraocular; D008297:Male; D008875:Middle Aged; D008916:Miotics / Q000008:administration & dosage / Q000009:adverse effects*; D013948:Moxisylyte / Q000008:administration & dosage / Q000009:adverse effects*; D009883:Ophthalmic Solutions; D018918:Phacoemulsification
D008916:Miotics; D009883:Ophthalmic Solutions; D000109:Acetylcholine; D013948:Moxisylyte
Endothelzellzahlreduktion durch Kataraktoperation bei intraokularer Anwendung von Thymoxamin. Randomisierte doppelt maskierte Studie.