Is CD46 the cellular receptor for measles virus?
Although CD46 would appear to be the cellular receptor for vaccine strains of measles virus (MV), recently there has been an accumulation of data suggesting that CD46 does not play this role for MV wild-type strains. Clarification of the nature of the MV receptor is necessary for the development of more effective vaccines against this virus which is responsible for the deaths of nearly two million children each year in the Third World.
Buckland
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Institut National de Sante et de la Recherche Médicale U. 404 Immunité et Vaccination, Institut Pasteur de Lyon, France.
Wild
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D000818:Animals; D015703:Antigens, CD / Q000378:metabolism*; D006386:Hemagglutination Tests; D006801:Humans; D008458:Measles Vaccine / Q000378:metabolism; D008459:Measles virus / Q000378:metabolism*; D051916:Membrane Cofactor Protein; D008562:Membrane Glycoproteins / Q000378:metabolism*; D011991:Receptors, Virus / Q000378:metabolism*; D014613:Vaccines, Attenuated / Q000378:metabolism; D014764:Viral Proteins / Q000378:metabolism
D015703:Antigens, CD; C497857:CD46 protein, human; D008458:Measles Vaccine; D051916:Membrane Cofactor Protein; D008562:Membrane Glycoproteins; D011991:Receptors, Virus; D014613:Vaccines, Attenuated; D014764:Viral Proteins