Dose dependent effects of yohimbine on methadone maintained patients.
Twelve methadone-maintained patients were randomized into a controlled crossover study with active and placebo yohimbine 20 mg once a day (n = 4), 5mg three times a day (n = 4) or 10 mg three times a day (n = 4) for seven days to evaluate the effect of yohimbine on naloxone precipitated opiate withdrawal. The yohimbine dose of 10 mg TID was well tolerated and was associated with an average decrease of 30% in precipitated withdrawal symptoms.
Hameedi
F A
FA
Department of Psychiatry, Yale School of Medicine, New Haven, Connecticut, USA.
Woods
S W
SW
Rosen
M I
MI
Pearsall
H R
HR
Kosten
T R
TR
D000284:Administration, Oral; D000317:Adrenergic alpha-Antagonists / Q000008:administration & dosage* / Q000627:therapeutic use*; D000328:Adult; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D008691:Methadone / Q000627:therapeutic use*; D008875:Middle Aged; D009270:Naloxone / Q000009:adverse effects; D009292:Narcotic Antagonists / Q000009:adverse effects; D009294:Narcotics; D013375:Substance Withdrawal Syndrome / Q000209:etiology; D019966:Substance-Related Disorders / Q000188:drug therapy*; D015016:Yohimbine / Q000008:administration & dosage* / Q000627:therapeutic use*
D000317:Adrenergic alpha-Antagonists; D009292:Narcotic Antagonists; D009294:Narcotics; D015016:Yohimbine; D009270:Naloxone; D008691:Methadone