Granulocytic sarcomas: clinical, diagnostic and therapeutical aspects.
Granulocytic sarcomas (GS) are extramedullary tumor masses of immature myeloid cells most frequently associated with acute myeloblastic leukemia. We report our diagnostic, clinic and therapeutic approaches in the treatment of 6 patients affected by GS who presented with different localizations and symptoms: mediastinal mass with chest pain, rectal tumor with bowel occlusion, bladder mass with acute kidney failure, quadriceps tumor with pain, vertebral localization with pain and bowel mass with pain, respectively. The correct diagnosis of GS by bone biopsy, the immunohistological evaluation of the tumor masses, the prompt use of active drugs in the first line therapy schedule as for acute myeloblastic leukemia are the parameters for the achievement of the long-term remission.
Martinelli
G
G
Istituto di Ematologia L e A. Seràgnoli, Ospedale S. Orsola-Malpighi, Università di Bologna, Italy.
Vianelli
N
N
De Vivo
A
A
Ricci
P
P
Remiddi
C
C
Testoni
N
N
Visani
G
G
Baravelli
S
S
Farabegoli
P
P
Tura
S
S
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002908:Chronic Disease; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007414:Intestinal Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000532:radiotherapy; D007951:Leukemia, Myeloid / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy; D008159:Lumbar Vertebrae; D008297:Male; D008479:Mediastinal Neoplasms / Q000188:drug therapy / Q000473:pathology; D008875:Middle Aged; D011859:Radiography; D012004:Rectal Neoplasms / Q000188:drug therapy / Q000473:pathology; D012983:Soft Tissue Neoplasms / Q000188:drug therapy / Q000473:pathology; D013125:Spinal Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy