Thrombotic syndromes and autoimmune diseases.
Maintenance of blood flow involves the dynamic interactions between the endothelium, circulating cellular components, coagulation factors, and factors involved in fibrinolysis. Autoantibodies, inflammatory cytokines and other undefined triggers in a genetically predisposed person may lead to an imbalance in the equilibrium between the various hemostatic pathways resulting in potentially catastrophic thrombotic events. This article reviews the clinical manifestations and treatment of selected, potentially life-threatening thrombotic syndromes that may occur in association with autoimmune diseases. Special mention is made of thrombotic events associated with Behçet's syndrome.
Fessler
B J
BJ
Department of Rheumatic and Immunologic Diseases, Cleveland Clinic Foundation, Ohio, USA.
D017152:Antibodies, Antiphospholipid / Q000097:blood; D001327:Autoimmune Diseases / Q000150:complications*; D001528:Behcet Syndrome / Q000150:complications; D006801:Humans; D013927:Thrombosis / Q000209:etiology* / Q000473:pathology / Q000628:therapy
D017152:Antibodies, Antiphospholipid