title: Inhibitory effects of funoran on the adherence and colonization of oral bacteria.
abstract: Funoran, a sulfated polysaccharide extracted from the seaweed Gloiopeltis furcata, strongly inhibited the adsorption of mutans streptococci to saliva-coated hydroxyapatite (S-HA) used as an experimental pellicle and strongly desorbed cariogenic mutans streptococci pre-adsorbed to S-HA. Colonization inhibition and anticariogenic effects of funoran were also investigated in experimental rats. The colonization of Streptococcus cricetus E49 inoculated on the molar teeth of experimental rats administered funoran was less frequent than that in a funoran-free group. The mean buccal and lingual, sulcal, and total caries scores of rat groups administered funoran were significantly lower than those of the funoran-free group. The inhibitory effect of funoran on periodontopathic bacterial attachment was studied in vitro. Funoran strongly inhibited the adsorption of Porphyromonas gingivalis, Fusobacterium nucleatum, and actinomyces species to S-HA and collagen-coated hydroxyapatite (Co-HA) and apparently inhibited their attachment to the human gingival fibroblast Gin-1 cell line. The present study indicates that funoran inhibits colonization by cariogenic and periodontopathic bacteria and excludes them from human oral cavity.
authors.affiliation: Department of Bio-Technology, Lotte Central Laboratory Co., Ltd., Saitama, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Saeki
authors.forename: T
authors.initials: T
authors.lastname: Kato
authors.forename: K
authors.initials: K
authors.lastname: Okuda
mesh_terms: D016924:Actinomyces viscosus / Q000187:drug effects / Q000502:physiology; D000328:Adult; D000818:Animals; D001422:Bacterial Adhesion / Q000187:drug effects*; D002460:Cell Line; D003094:Collagen / Q000502:physiology; D017886:Durapatite; D005347:Fibroblasts / Q000502:physiology; D016967:Fusobacterium nucleatum / Q000187:drug effects / Q000502:physiology; D006801:Humans; D011134:Polysaccharides / Q000494:pharmacology*; D016966:Porphyromonas gingivalis / Q000187:drug effects / Q000502:physiology; D051381:Rats; D012463:Saliva / Q000502:physiology; D013291:Streptococcus / Q000187:drug effects / Q000502:physiology
chemical_list: D011134:Polysaccharides; D003094:Collagen; C093529:funoran; D017886:Durapatite