title: De novo familial cavernous malformation presenting with hemorrhage 12.5 years after the initial hemorrhagic Ictus: natural history of an infantile form.
abstract: Cerebral cavernous malformations are congenital, non-neoplastic lesions, but they are known for their potential for growth. De novo lesion genesis is exceptional and occurs more commonly with the familial form of the disease. We report the case of a 13-year-old Caucasian boy with a positive family history, who underwent surgery for a left parietal hemorrhage during the 1st year of life and who recently presented with a new hemorrhage in the left temporal lobe quite distant from the previous hematoma bed. Both hemorrhages were caused by cavernous malformations. Sequential magnetic resonance scans prior to the recent presentation failed to disclose the growth of the new lesion. We reviewed the literature for mechanisms of new lesion formation.
authors.affiliation: Division of Pediatric Neurosurgery, Children's Hospital of Eastern Ontario, University of Ottawa Faculty of Medicine, Canada.
authors.forename: I H
authors.initials: IH
authors.lastname: Tekkök
authors.forename: E C
authors.initials: EC
authors.lastname: Ventureyra
mesh_terms: D000293:Adolescent; D001932:Brain Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000601:surgery; D002543:Cerebral Hemorrhage / Q000175:diagnosis / Q000235:genetics* / Q000601:surgery; D006392:Hemangioma, Cavernous / Q000175:diagnosis / Q000235:genetics* / Q000601:surgery; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D016609:Neoplasms, Second Primary / Q000175:diagnosis / Q000235:genetics* / Q000601:surgery; D012086:Reoperation; D013702:Temporal Lobe / Q000473:pathology / Q000601:surgery