title: HLA association and occurrence of autoantibodies in Asian-Indian patients with ulcerative colitis.
abstract: OBJECTIVE
  The purpose of the present study was to determine the profile of HLA class I antigens, antinuclear antibodies (ANA), and antineutrophil cytoplasmic antibodies (ANCA) in ulcerative colitis (UC) patients from Northern India.
  
  
  METHODS
  The study consisted of 100 UC patients with or without extraintestinal manifestations. Data on HLA, ANA, and ANCA were analyzed with respect to age at onset, sex, duration of disease, and occurrence of extraintestinal manifestations, and data were correlated with those of healthy controls from the same population.
  
  
  RESULTS
  The most common extraintestinal manifestations in order of occurrence were arthralgia (53.8%), ocular lesions (18%), sacroiliitis (12.7%), hepatobiliary (7.7%), cutaneous (5%), and vascular (2.6%). ANA and ANCA were positive in only 3% of cases. Of the HLA class I antigens, HLA-A19 was significantly increased in UC patients compared with controls (63.4% vs. 33.5%, p < 0.001, RR = 3.4), particularly its subtype HLA-A33 (20.7% vs. 4%, p < 0.001, RR = 6.3). There was no deviation in the frequency of HLA-B locus antigens, whereas HLA-Cw6 was increased significantly in patients compared with controls (14.6% vs. 3.5%, p < 0.001, RR = 4.4).
  
  
  CONCLUSIONS
  The occurrence of extraintestinal manifestations in Indian patients with UC is similar to that reported elsewhere, although ANA and ANCA positivity is lower. HLA studies revealed that A19(33) and Cw6 are associated with UC.
authors.affiliation: Department of Histocompatibility and Immunogenetics, All India Institute of Medical Sciences, New Delhi.
authors.forename: M A
authors.initials: MA
authors.lastname: Habeeb
authors.forename: R
authors.initials: R
authors.lastname: Rajalingam
authors.forename: A
authors.initials: A
authors.lastname: Dhar
authors.forename: A
authors.initials: A
authors.lastname: Kumar
authors.forename: M P
authors.initials: MP
authors.lastname: Sharma
authors.forename: N K
authors.initials: NK
authors.lastname: Mehra
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000097:blood*; D000974:Antibodies, Antinuclear / Q000097:blood*; D003093:Colitis, Ulcerative / Q000208:ethnology* / Q000276:immunology* / Q000473:pathology; D005260:Female; D006680:HLA Antigens / Q000097:blood*; D015234:HLA-A Antigens / Q000097:blood; D015235:HLA-B Antigens / Q000097:blood; D015236:HLA-C Antigens / Q000097:blood; D006801:Humans; D007194:India / Q000208:ethnology; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index; D012737:Sex Factors; D013997:Time Factors
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic; D000974:Antibodies, Antinuclear; D006680:HLA Antigens; D015234:HLA-A Antigens; D015235:HLA-B Antigens; D015236:HLA-C Antigens