title: Dynamin genes Dnm1 and Dnm2 are located on proximal mouse chromosomes 2 and 9, respectively.
abstract: Dynamins, microtubule-binding GTPases, are encoded by at least three genes in mammals. Two distinct gene-specific cDNAs were used to analyze the segregation of dynamin genes Dnm1 and Dnm2 in a mouse interspecies backcross. The nervous system-expressed gene Dnm1 was localized to Chr 2 between the genes for vimentin and nebulin, within a chromosomal region of conserved synteny to human chromosome 9q, consistent with the localization of the human dynamin-1 gene by FISH (see accompanying paper by Newman-Smith et al., 1997, Genomics 41:286-289). The ubiquitously expressed Dnm2 gene was found to be closely linked to the intercellular adhesion molecule-1 gene, Icam1, in a region with homologies to human chromosomes 19p, 8q, and 11q. Potential relations of both loci to disease genes are discussed.
authors.affiliation: Developmental Biology Unit W7, University of Bielefeld, Germany.
authors.forename: R
authors.initials: R
authors.lastname: Klocke
authors.forename: A
authors.initials: A
authors.lastname: Augustin
authors.forename: M
authors.initials: M
authors.lastname: Ronsiek
authors.forename: A
authors.initials: A
authors.lastname: Stief
authors.forename: H
authors.initials: H
authors.lastname: van der Putten
authors.forename: H
authors.initials: H
authors.lastname: Jockusch
mesh_terms: D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping; D018076:DNA, Complementary; D034284:Dynamin I; D034281:Dynamins; D005260:Female; D020558:GTP Phosphohydrolases / Q000235:genetics*; D006801:Humans; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008870:Microtubules / Q000378:metabolism*; D008969:Molecular Sequence Data
chemical_list: D018076:DNA, Complementary; D034284:Dynamin I; D020558:GTP Phosphohydrolases; D034281:Dynamins