Maternal inheritance of atopy at the Fc epsilon RI beta locus in Japanese sibs.
Twenty-four Japanese atopic sibs with asthma and/or rhinitis were tested for polymorphic microsatellite repeats of Fc epsilon RI beta on chromosome 11q13. Significantly increased sharing of maternal alleles was found chi 2 = 5.86, p < 0.025) while no significant sharing was found for paternal alleles. These findings confirm maternal inheritance of atopy at this locus in a non-Caucasian population.
Mao
X O
XO
Department of Hygiene and Preventive Medicine, Osaka University School of Medicine, Suita, Japan.
Shirakawa
T
T
Sasaki
S
S
Enomoto
T
T
Morimoto
K
K
Hopkin
J M
JM
D001249:Asthma / Q000235:genetics; D002880:Chromosomes, Human, Pair 11; D018900:Dinucleotide Repeats / Q000235:genetics*; D005260:Female; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000235:genetics*; D007564:Japan; D009679:Nuclear Family; D011110:Polymorphism, Genetic; D017455:Receptors, IgE / Q000235:genetics*; D012220:Rhinitis / Q000235:genetics
D017455:Receptors, IgE