title: Genetic renal mechanisms of hypertension.
abstract: An update on renal genetic mechanisms of spontaneous hypertension in rats and in human essential hypertension is presented. The findings are discussed, highlighting the search of a possible link between the discovered genetic abnormality and the renal function changes that may determine the disease. The analogies (and/or differences) between the numerous positive findings obtained in animal models and the relatively scarce ones obtained in humans are discussed.
authors.affiliation: Division of Nephrology, Dialysis and Hypertension and Postgraduate School of Nephrology, University of Milano, S. Raffaele Hospital, Italy.
authors.forename: D
authors.initials: D
authors.lastname: Cusi
mesh_terms: D000808:Angiotensinogen / Q000235:genetics; D000818:Animals; D009320:Atrial Natriuretic Factor / Q000235:genetics; D002148:Calmodulin-Binding Proteins / Q000235:genetics; D042926:Cytochrome P-450 CYP4A; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics; D016232:Endothelins / Q000235:genetics; D005190:Family; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D006899:Mixed Function Oxygenases / Q000235:genetics; D008955:Models, Cardiovascular; D019001:Nitric Oxide Synthase / Q000235:genetics; D007703:Peptidyl-Dipeptidase A / Q000235:genetics; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D017461:Receptors, Atrial Natriuretic Factor / Q000235:genetics; D012083:Renin / Q000235:genetics; D015222:Sodium Channels / Q000235:genetics; D000099291:Adducins
chemical_list: D000808:Angiotensinogen; D009320:Atrial Natriuretic Factor; D002148:Calmodulin-Binding Proteins; D042926:Cytochrome P-450 CYP4A; D003577:Cytochrome P-450 Enzyme System; D016232:Endothelins; D006899:Mixed Function Oxygenases; D019001:Nitric Oxide Synthase; D007703:Peptidyl-Dipeptidase A; D017461:Receptors, Atrial Natriuretic Factor; D012083:Renin; D015222:Sodium Channels; D000099291:Adducins