title: [Dynamics of ultrastructural changes in guinea pig cardiomyocytes in experimental diphtheria intoxication].
abstract: Electron microscopy of the left and right ventricles from guinea pigs was made 24, 72, and 120 hours after they were administered diphtheria toxin, 0.3 DLM/kg. The important pathogenetic mechanism responsible for dysfunction of the "diphtheritic heart" was found to be left and right ventricular cardiomyocytic lesion discordance developing in the mid-process, by causing serious intracardiac hemodynamic disorders. The lysosomal system influencing the ultrastructure of the two ventricles may exist in the heart. In diphtheritic intoxication, cardiomyocytic lysosomes exert mainly a damaging effect on their ultrastructure.
authors.forename: V A
authors.initials: VA
authors.lastname: Frolov
authors.forename: P
authors.initials: P
authors.lastname: Riger
authors.forename: A V
authors.initials: AV
authors.lastname: Pasechnik
authors.forename: A M
authors.initials: AM
authors.lastname: Avanesov
mesh_terms: D000818:Animals; D004167:Diphtheria Toxin / Q000633:toxicity*; D006168:Guinea Pigs; D008854:Microscopy, Electron; D018487:Ventricular Dysfunction, Left / Q000139:chemically induced* / Q000473:pathology; D018497:Ventricular Dysfunction, Right / Q000139:chemically induced* / Q000473:pathology
chemical_list: D004167:Diphtheria Toxin
vernacular_title: Dinamika izmeneniĭ ul'trastruktury kardiomiotsitov morskoĭ pri difteriĭnoĭ intoksikatsii v éksperimente.