Aggressive gastric peripheral T-cell lymphoma of CD8+ type associated with lymphomatous meningitis.
Most gastric lymphomas are of B-cell origin, and many are either low-grade or high-grade B-cell lymphomas of mucosa-associated lymphoid tissue type. Gastric T-cell lymphomas are very rare, usually of CD4+ type, and few have had genotypic studies. We report the case of a gastric peripheral T-cell lymphoma of CD8+ type. Genotypic studies demonstrated partial deletion with rearrangement of the T-cell receptor beta-chain gene. Lymphomatous meningitis developed, and the patient died after only 2 months despite chemotherapy. The case is compared with the other gastric T-cell lymphomas that have been reported.
Holst
V A
VA
Department of Pathology, University of Pittsburgh Medical Center, Pennsylvania 15213-2582, USA.
Locker
J
J
Gleason
J A
JA
Swerdlow
S H
SH
D000368:Aged; D018951:Antigens, CD20 / Q000032:analysis; D015415:Biomarkers / Q000032:analysis; D001706:Biopsy; D017252:CD3 Complex / Q000032:analysis; D016827:CD8 Antigens / Q000032:analysis*; D016543:Central Nervous System Neoplasms / Q000556:secondary; D017809:Fatal Outcome; D005434:Flow Cytometry; D006801:Humans; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D016411:Lymphoma, T-Cell, Peripheral / Q000737:chemistry / Q000473:pathology*; D008297:Male; D008581:Meningitis / Q000473:pathology; D013274:Stomach Neoplasms / Q000473:pathology*
D018951:Antigens, CD20; D015415:Biomarkers; D017252:CD3 Complex; D016827:CD8 Antigens