Aggressive natural killer (NK) cell lymphoma: report of a pediatric case and review of the literature.
We report a rare pediatric case of aggressive natural killer (NK) cell lymphoma, characterized by acute onset hepatosplenomegaly and respiratory distress, and infiltration by large granular lymphocytes with the phenotype of CD3-CD16-CD56+. The patient has remained in complete remission after short-pulse intensive chemotherapy, and myeloablative therapy followed by allogeneic bone marrow transplantation. We compare our case with 7 other children with NK cell leukemia reported from other institutions.
Ohnuma
K
K
Department of Oncology, Kanagawa Children's Medical Center, Japan.
Toyoda
Y
Y
Nishihira
H
H
Iguchi
A
A
Honda
K
K
Nagao
T
T
Kigasawa
H
H
Tanaka
Y
Y
Kikuta
H
H
D000293:Adolescent; D000954:Antigens, Surface / Q000378:metabolism; D016026:Bone Marrow Transplantation; D002648:Child; D005260:Female; D005334:Fever; D006086:Graft vs Host Disease / Q000188:drug therapy; D004854:Herpesvirus 4, Human; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology* / Q000473:pathology*; D007938:Leukemia / Q000473:pathology; D008099:Liver / Q000473:pathology; D008223:Lymphoma / Q000276:immunology / Q000473:pathology* / Q000628:therapy*; D008297:Male; D012074:Remission Induction; D013154:Spleen / Q000473:pathology
D000954:Antigens, Surface