title: Increased paternal age in CHARGE association.
abstract: The acronym CHARGE refers to a non-random clustering of congenital malformations whose cause remains unknown. Here, we report on a series of 41 patients and find a significant increase in mean paternal age of birth of CHARGE patients (33.7 +/- 8 years) compared with the control population (30.8 +/- 5 years). In contrast, maternal age was not statistically different in patients and controls. These data suggest the possible role of a dominant mutation or, less likely, a subtle chromosomal abnormality in CHARGE association.
authors.affiliation: Service de Génétique Médicale, Hôpital des Enfants Malades, Paris, France.
authors.forename: A L
authors.initials: AL
authors.lastname: Tellier
authors.forename: S
authors.initials: S
authors.lastname: Lyonnet
authors.forename: V
authors.initials: V
authors.lastname: Cormier-Daire
authors.forename: P
authors.initials: P
authors.lastname: de Lonlay
authors.forename: V
authors.initials: V
authors.lastname: Abadie
authors.forename: C
authors.initials: C
authors.lastname: Baumann
authors.forename: D
authors.initials: D
authors.lastname: Bonneau
authors.forename: P
authors.initials: P
authors.lastname: Labrune
authors.forename: D
authors.initials: D
authors.lastname: Lacombe
authors.forename: M
authors.initials: M
authors.lastname: Le Merrer
authors.forename: A
authors.initials: A
authors.lastname: Nivelon
authors.forename: N
authors.initials: N
authors.lastname: Philip
authors.forename: M L
authors.initials: ML
authors.lastname: Briard
authors.forename: A
authors.initials: A
authors.lastname: Munnich
mesh_terms: D000015:Abnormalities, Multiple / Q000235:genetics*; D000328:Adult; D002648:Child; D002675:Child, Preschool; D003103:Coloboma / Q000235:genetics; D003638:Deafness / Q000235:genetics; D004423:Ear / Q000002:abnormalities; D005260:Female; D005835:Genitalia / Q000002:abnormalities; D006330:Heart Defects, Congenital / Q000235:genetics; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009296:Nasal Cavity / Q000002:abnormalities; D010331:Paternal Age; D013577:Syndrome