Structure determination of yeast cofilin.
Cofilin, a ubiquitous 15,000 M(r) protein, plays a central role in regulating cytoskeletal dynamics. Cofilin binds to actin monomers and filaments, and has a pH-dependent actin severing activity. The structure will allow for a detailed analysis of cofilin function.
Fedorov
A A
AA
Lappalainen
P
P
Fedorov
E V
EV
Drubin
D G
DG
Almo
S C
SC
D051339:Actin Depolymerizing Factors; D000595:Amino Acid Sequence; D018360:Crystallography, X-Ray; D008840:Microfilament Proteins / Q000737:chemistry*; D008958:Models, Molecular; D008969:Molecular Sequence Data; D009419:Nerve Tissue Proteins / Q000737:chemistry*; D017433:Protein Structure, Secondary; D012441:Saccharomyces cerevisiae / Q000737:chemistry*; D017386:Sequence Homology, Amino Acid
D051339:Actin Depolymerizing Factors; D008840:Microfilament Proteins; D009419:Nerve Tissue Proteins