SCE analysis in peripheral blood lymphocytes of a group of filling station attendants.
Petroleum derivatives constitute a complex mixture of chemicals which contain known genotoxicants. Thus, chronic occupational exposure to such derivatives may be considered to possess genotoxic risk. Service station attendants are workers exposed to petroleum derivatives and, as consequence, biomonitoring studies designed to evaluate the genetic risk are required. Here we present the data on sister chromatid exchange (SCE) frequencies, proliferation rate index (PRI) and cells with high frequency of SCE (HFC) from a group of 42 attendant workers. In addition, data from a group of 45 unexposed (controls) are presented. The results obtained indicate that there are no significant differences in SCE values between the exposed workers when compared to the non-exposed individuals. The only difference is found when smoking habit is considered, the smokers having significant increases in the SCE frequency. There is a slight increase in the HFC frequency of the occupationally exposed group but the difference did not attain statistical significance.
Pitarque
M
M
Departament de Genètica i de Microbiologia, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, Spain.
Carbonell
E
E
Lapeña
N
N
Marsá
M
M
Valbuena
A
A
Creus
A
A
Marcos
R
R
D000328:Adult; D000393:Air Pollutants / Q000032:analysis / Q000633:toxicity*; D000428:Alcohol Drinking; D001554:Benzene / Q000032:analysis / Q000633:toxicity; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D005742:Gasoline / Q000633:toxicity*; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects* / Q000502:physiology; D008297:Male; D008875:Middle Aged; D015233:Models, Statistical; D016273:Occupational Exposure; D012854:Sister Chromatid Exchange / Q000187:drug effects*; D012907:Smoking; D013997:Time Factors; D014050:Toluene / Q000032:analysis / Q000633:toxicity; D014992:Xylenes / Q000032:analysis / Q000633:toxicity
D000393:Air Pollutants; D005742:Gasoline; D014992:Xylenes; D014050:Toluene; D001554:Benzene