Nuclear organization and gene expression: homologous pairing and long-range interactions.
Genetic studies have demonstrated that pairing interactions between homologous chromosomes and long-range associations between nonhomologous sites can influence gene expression. Recent work has revealed that such influences are widespread in eukaryotes and that chromosome architecture is likely to be of fundamental importance for nuclear structure and function.
Henikoff
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Howard Hughes Medical Institute, Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98104, USA. steveh@howard.fhcrc.org
D000483:Alleles; D000818:Animals; D002467:Cell Nucleus / Q000648:ultrastructure*; D002875:Chromosomes / Q000502:physiology*; D004331:Drosophila melanogaster / Q000235:genetics; D005786:Gene Expression Regulation; D006570:Heterochromatin / Q000502:physiology; D006579:Heterozygote; D011995:Recombination, Genetic; D012441:Saccharomyces cerevisiae; D017386:Sequence Homology, Amino Acid; D013329:Structure-Activity Relationship; D015533:Transcriptional Activation; D019076:Transgenes
D006570:Heterochromatin