title: Disseminated mycosis due to Scedosporium prolificans in an AIDS patient with Burkitt lymphoma.
abstract: A case of fatal disseminated infection caused by the dematiaceous hyphomycete Scedosporium prolificans diagnosed post mortem is reported in a 60-year-old male patient with acquired immunodeficiency syndrome who additionally suffered from Burkitt's lymphoma. The patient was significantly granulocytopenic following aggressive chemotherapy and irradiation. He developed dyspnoea at rest and chest pain despite a normal chest radiograph. Fluconazole treatment was carried out empirically because no sign of a fungal infection was detected ante mortem, either by mycological cultivation or by serological investigation. First post-mortem examination revealed a disseminated fungal infection involving the central nervous system. Scedosporium prolificans was cultured from the kidney, spleen and myocardium. In vitro, the fungal isolate was found to be highly resistant to all available systemic antimycotics.
authors.affiliation: Department of Dermatology, University of Leipzig, Germany.
authors.forename: P
authors.initials: P
authors.lastname: Nenoff
authors.forename: U
authors.initials: U
authors.lastname: Gütz
authors.forename: K
authors.initials: K
authors.lastname: Tintelnot
authors.forename: A
authors.initials: A
authors.lastname: Bosse-Henck
authors.forename: M
authors.initials: M
authors.lastname: Mierzwa
authors.forename: J
authors.initials: J
authors.lastname: Hofmann
authors.forename: L C
authors.initials: LC
authors.lastname: Horn
authors.forename: U F
authors.initials: UF
authors.lastname: Haustein
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy / Q000382:microbiology*; D000935:Antifungal Agents / Q000627:therapeutic use; D002051:Burkitt Lymphoma / Q000150:complications*; D015725:Fluconazole / Q000627:therapeutic use; D006801:Humans; D008168:Lung / Q000382:microbiology / Q000473:pathology; D008172:Lung Diseases, Fungal / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D016483:Lymphoma, AIDS-Related / Q000150:complications*; D008297:Male; D008875:Middle Aged; D003904:Mitosporic Fungi / Q000145:classification / Q000302:isolation & purification
chemical_list: D000935:Antifungal Agents; D015725:Fluconazole