Lack of association of angiotensin I-converting enzyme gene polymorphism and premature myocardial infarction in Mauritian Indians.
Eighty-five young Mauritian Indians, male survivors of premature myocardial infarction (MI) and thus belonging to a high risk group, were compared with 108 stringently selected controls for a possible association between premature MI and an insertion/deletion (I/D) polymorphism in the gene encoding angiotensin I-converting enzyme (ACE). The frequency of the D allele was 0.42 in the MI group and 0.43 in the control group, and thus no association between I/D polymorphism of ACE with susceptibility to early-onset MI was found in this population group. Other gene components of the renin-angiotensin system and lipid metabolism need to be explored to understand the genetic factors involved in causing MI at an early age.
Ramasawmy
R
R
INSERM U120, Paris, France.
Manraj
M
M
Kotea
N
N
Shun
N K
NK
Genin
E
E
Feingold
J
J
Krishnamoorthy
R
R
Baligadoo
S
S
D000328:Adult; D017668:Age of Onset; D005006:Ethnicity / Q000235:genetics*; D005838:Genotype; D006801:Humans; D007194:India / Q000208:ethnology; D008297:Male; D008436:Mauritius / Q000453:epidemiology; D008875:Middle Aged; D009203:Myocardial Infarction / Q000201:enzymology / Q000208:ethnology* / Q000235:genetics; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic
D007703:Peptidyl-Dipeptidase A