V beta 8+CD4-CD8- subpopulation induced by staphylococcal enterotoxin B.
Injection of staphylococcal enterotoxin B (SEB) into BALB/c mice induced the depletion of V beta 8+ T-cells which were either V beta 8+CD4+ or V beta 8+CD8+ cells. The CD8 molecule on V beta 8+CD8+ cells was found to decrease at 72 h after SEB treatment while the V beta 8 molecule on V beta 8+ cells or CD4 molecule on V beta 8+CD4+ cells was not affected. Furthermore, a subpopulation of V beta 8+CD4-CD8- T-cells was also induced after SEB-priming. This subpopulation can be found in spleen or lymph nodes. It was small in size and constituted the major part of V beta 8+ cells in lymph nodes at 72 h after SEB-priming. Some of the V beta 8+CD4-CD8- T-cells might be autoreactive because they could be stimulated to proliferative by syngenic mitomycin C-treated splenocytes.
Chou
M C
MC
Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, Taiwan, ROC.
Lee
S C
SC
Lin
Y S
YS
Lei
H Y
HY
D000818:Animals; D015704:CD4 Antigens / Q000276:immunology*; D016827:CD8 Antigens / Q000276:immunology*; D004768:Enterotoxins / Q000008:administration & dosage*; D008212:Lymphocyte Depletion; D051379:Mice; D008807:Mice, Inbred BALB C; D051381:Rats; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000276:immunology*; D018089:Superantigens / Q000008:administration & dosage*; D013601:T-Lymphocytes / Q000145:classification / Q000276:immunology*
D015704:CD4 Antigens; D016827:CD8 Antigens; D004768:Enterotoxins; D016693:Receptors, Antigen, T-Cell, alpha-beta; D018089:Superantigens; C031818:enterotoxin B, staphylococcal