title: (RS)-2-chloro-5-hydroxyphenylglycine (CHPG) activates mGlu5, but no mGlu1, receptors expressed in CHO cells and potentiates NMDA responses in the hippocampus.
abstract: A new phenylglycine derivative, (RS)-2-chloro-5-hydroxyphenylglycine (CHPG), has been synthesized and shown to selectively activate mGlu5a receptors, compared to mGlu1 alpha receptors, when expressed in CHO cells. This selective mGlu5 receptor agonist also potentiates NMDA-induced depolarizations in rat hippocampal slices. CHPG may be a useful tool for studying the role of mGlu5 receptors in the central nervous system.
authors.affiliation: Department of Anatomy, School of Medical Sciences, University of Bristol, UK.
authors.forename: A J
authors.initials: AJ
authors.lastname: Doherty
authors.forename: M J
authors.initials: MJ
authors.lastname: Palmer
authors.forename: J M
authors.initials: JM
authors.lastname: Henley
authors.forename: G L
authors.initials: GL
authors.lastname: Collingridge
authors.forename: D E
authors.initials: DE
authors.lastname: Jane
mesh_terms: D000818:Animals; D016466:CHO Cells; D002118:Calcium / Q000378:metabolism; D006224:Cricetinae; D018690:Excitatory Amino Acid Agonists / Q000494:pharmacology*; D005998:Glycine / Q000031:analogs & derivatives* / Q000494:pharmacology; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism*; D066298:In Vitro Techniques; D016202:N-Methylaspartate / Q000494:pharmacology*; D010648:Phenylacetates / Q000494:pharmacology*; D051381:Rats; D018094:Receptors, Metabotropic Glutamate / Q000187:drug effects*
chemical_list: C107349:2-chloro-5-hydroxyphenylglycine; D018690:Excitatory Amino Acid Agonists; D010648:Phenylacetates; D018094:Receptors, Metabotropic Glutamate; D016202:N-Methylaspartate; D002118:Calcium; D005998:Glycine