Serum selenium versus lymphocyte subsets and markers of disease progression and inflammatory response in human immunodeficiency virus-1 infection.
Serum selenium levels were determined cross-sectionally in 57 HIV-infected patients who were classified according to the Centers for Disease Control (CDC) 1993 classification system. Mean serum selenium levels were lower in CDC stage II (58.7 +/- 12.2 micrograms/L; p < 0.01; n = 18) and stage III (47.6 +/- 11.3 micrograms/L; p < 0.01; n = 19) HIV-infected patients, than in healthy subjects (80.6 +/- 9.6 micrograms/L; n = 48) and stage I patients (73.6 +/- 16.5 micrograms/L; n = 20). Serum selenium levels were positively correlated with CD4 count, CD4/8 ratio, hematocrit, and serum albumin (r = 0.42; r = 0.39; r = 0.48; and r = 0.45; p < 0.01, respectively) and inversely with serum levels of thymidine kinase (r = -0.49; p < 0.01; n = 49) and beta 2-microglobulin (r = -0.46; p < 0.001; n = 49). In addition, serum selenium levels in 20 randomly selected AIDS-free individuals (CDC I: n = 10; CDC II: n = 10) were inversely correlated with serum concentrations of interleukin-8 (IL-8) and soluble tumor necrosis factor receptors (sTNFR) types I and II. There was no correlation with serum immuneglobulin A and total serum protein levels. The results show that the progressive deprivation of serum selenium in HIV-infection is associated with loss of CD(4+)-cells and with increased levels of markers of disease progression and inflammatory response.
Look
M P
MP
Department of General Internal Medicine, University of Bonn, Germany.
Rockstroh
J K
JK
Rao
G S
GS
Kreuzer
K A
KA
Spengler
U
U
Sauerbruch
T
T
D000328:Adult; D015415:Biomarkers; D018791:CD4 Lymphocyte Count; D016516:CD4-CD8 Ratio; D016022:Case-Control Studies; D005260:Female; D015658:HIV Infections / Q000097:blood* / Q000209:etiology / Q000276:immunology*; D015497:HIV-1; D006801:Humans; D007249:Inflammation / Q000209:etiology; D016209:Interleukin-8 / Q000097:blood; D008297:Male; D008875:Middle Aged; D018124:Receptors, Tumor Necrosis Factor / Q000378:metabolism; D012643:Selenium / Q000097:blood* / Q000172:deficiency*; D013937:Thymidine Kinase / Q000097:blood; D001613:beta 2-Microglobulin / Q000378:metabolism
D015415:Biomarkers; D016209:Interleukin-8; D018124:Receptors, Tumor Necrosis Factor; D001613:beta 2-Microglobulin; D013937:Thymidine Kinase; D012643:Selenium