title: Effect of a two-solution fluoride mouth rinse on deposition of loosely bound fluoride on sound root tissue and remineralization of root lesions in vitro.
abstract: A constant-composition fluoride (F) titration method was used to measure the amount of leachable F deposited on root surfaces in vitro by a 1-min rinse with a 12 mmol/l sodium fluoride (228 micrograms/g F) solution or a two-solution rinse that contained 2 mmol/l sodium fluorosilicate (228 micrograms/g total F ) and 10 mmol/l calcium chloride. The mean +/- standard deviations (n = 3) F uptake from the two rinse treatments were 0.70 +/- 0.24 micrograms/cm2 and 3.25 +/- 0.74 micrograms/cm2, respectively. In a separate experiment, the effects of sodium fluoride and the two-solution rinses on remineralization of root lesions were evaluated in an in vitro pH cycling model. The results showed that the average decrease in mineral loss (delta Z) in the two-solution rinse group (60%) was significantly greater than that obtained in the NaF rinse (41%) or the control (9%) group.
authors.affiliation: American Dental Association Health Foundation, Paffenbarger Research Center, National Institute of Standards and Technology, Gaithersburg, MD, USA.
authors.forename: S
authors.initials: S
authors.lastname: Takagi
authors.forename: L C
authors.initials: LC
authors.lastname: Chow
authors.forename: S
authors.initials: S
authors.lastname: Shih
authors.forename: B A
authors.initials: BA
authors.lastname: Sieck
mesh_terms: D017607:Aluminum Compounds / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use; D000704:Analysis of Variance; D002122:Calcium Chloride / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use; D002327:Cariostatic Agents / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D005459:Fluorides / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008903:Minerals / Q000032:analysis; D009067:Mouthwashes; D017213:Root Caries / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy*; D012824:Silicic Acid / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use; D012969:Sodium Fluoride / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use; D017001:Tooth Demineralization / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy; D014089:Tooth Remineralization; D014092:Tooth Root / Q000187:drug effects* / Q000378:metabolism
chemical_list: D017607:Aluminum Compounds; D002327:Cariostatic Agents; D008903:Minerals; D009067:Mouthwashes; D012824:Silicic Acid; C004832:hexafluorosilicate; D012969:Sodium Fluoride; D002122:Calcium Chloride; D005459:Fluorides; C032311:aluminum fluoride