title: Is esophagectomy following upfront chemoradiotherapy safe and necessary?
abstract: OBJECTIVE
  To examine the safety and necessity of esophagectomy following upfront chemoradiotherapy (CRT) in patients with potentially resectable esophageal cancer.
  
  
  METHODS
  Cohort analytic study during a 4-year period.
  
  
  METHODS
  Tertiary referral center.
  
  
  METHODS
  Thirty-seven patients who completed CRT and underwent esophagectomy as compared with 30 patients who underwent esophagectomy alone without pretreatment during the same period.
  
  
  METHODS
  Resection-related events, perioperative morbidity and mortality, response to CRT, site of residual disease following CRT, and survival of partial responders.
  
  
  RESULTS
  Patients receiving CRT followed by esophagectomy were similar to patients who underwent esophagectomy alone for operative characteristics, postoperative course, and perioperative morbidity and mortality. Of the 33 patients who achieved an objective response to CRT, 23 had residual tumor in the resection specimen. Of the 18 patients alive with no evidence of disease at a median follow-up of 30 months, 50% had residual tumor following CRT.
  
  
  CONCLUSIONS
  Upfront CRT did not adversely affect resection-related outcome and may facilitate resection by downstaging disease. A considerable number of patients had prolonged survival after esophageal resection despite having residual tumor present following treatment with upfront CRT. Therefore, esophagectomy following upfront CRT can improve locoregional control of disease and should remain a critical component of any multimodality regimen.
authors.affiliation: Department of Surgery, University of Pittsburgh, USA.
authors.forename: J M
authors.initials: JM
authors.lastname: Kane
authors.forename: L L
authors.initials: LL
authors.lastname: Shears
authors.forename: U
authors.initials: U
authors.lastname: Ribeiro
authors.forename: M R
authors.initials: MR
authors.lastname: Clark
authors.forename: M
authors.initials: M
authors.lastname: Peterson
authors.forename: R J
authors.initials: RJ
authors.lastname: Landreneau
authors.forename: M C
authors.initials: MC
authors.lastname: Posner
mesh_terms: D000368:Aged; D015331:Cohort Studies; D003131:Combined Modality Therapy; D004938:Esophageal Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery*; D016629:Esophagectomy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged