title: Carnitine depletion during total parenteral nutrition despite oral L-carnitine supplementation.
abstract: Carnitine CAR) plays an important role in the beta-oxidation of fatty acids. Less attention. however, has been paid to CAR compared to other nutrients even in total parenteral nutrition (TPN). To examine CAR metabolism during TPN and the effect of simultaneous oral L-CAR supplementation on CAR levels, the blood CAR level was measured in a 3-year-old boy receiving long-term TPN because of short bowel syndrome. Both the total and acyl CAR in the serum were evaluated under various nutritional conditions including oral supplementation of L-CAR. Low CAR concentrations were observed especially when lipid containing TPN regimens were in place. Oral L-CAR supplementation was not sufficient to restore the low CAR levels in the present index patient even when the dose was increased to 120 mg/kg in accordance with the result of the L-CAR absorption test that revealed poor intestinal absorption of this nutrient. Moreover, a markedly low CAR level was measured during the onset of sepsis in the patient, and the blood CAR was depleted when lipid metabolism was activated by lipid loading or sepsis. To date, the late effects of CAR depletion on child growth have not been well examined. It is recommended that the blood CAR level be maintained at normal levels before any prominent manifestations of the deficiency have developed. The intravenous administration of CAR appears to be necessary to supply a sufficient amount of CAR for patients with severe malabsorption.
authors.affiliation: Department of Pediatrics, Fukuoka University, School of Medicine, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Hirose
authors.forename: M
authors.initials: M
authors.lastname: Hirata
authors.forename: N
authors.initials: N
authors.lastname: Azuma
authors.forename: Z
authors.initials: Z
authors.lastname: Shirai
authors.forename: A
authors.initials: A
authors.lastname: Mitudome
authors.forename: T
authors.initials: T
authors.lastname: Oda
mesh_terms: D000284:Administration, Oral; D002331:Carnitine / Q000008:administration & dosage / Q000378:metabolism; D002675:Child, Preschool; D006801:Humans; D007408:Intestinal Absorption; D008297:Male; D010289:Parenteral Nutrition, Total; D012778:Short Bowel Syndrome / Q000378:metabolism* / Q000503:physiopathology
chemical_list: D002331:Carnitine