Listeria monocytogenes infection in mice treated with pentoxifylline.
The course of L. monocytogenes infection was followed in mice treated with pentoxifylline (POF), a known inhibitor of endogenous tumor necrosis factor (TNF) formation. Administration of POF caused a delay in L. monocytogenes elimination which was probably related to a reduction the listericidal activity of macrophages and to an attenuation of delayed type hypersensitivity (DTH) to Listeria antigens. In spite of this, some POF-treated mice were protected from lethal effects of virulent L. monocytogenes bacteria.
Brzychcy
M
M
Department of Infectious Biology, University of Lodz, Poland.
Klink
M
M
Tchórzewski
H
H
Rudnicka
W
W
D000818:Animals; D002478:Cells, Cultured; D004195:Disease Models, Animal; D005260:Female; D006968:Hypersensitivity, Delayed; D008088:Listeriosis / Q000188:drug therapy* / Q000382:microbiology; D017737:Macrophages, Peritoneal / Q000166:cytology / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D010431:Pentoxifylline / Q000627:therapeutic use*; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors* / Q000378:metabolism
D014409:Tumor Necrosis Factor-alpha; D010431:Pentoxifylline