title: Bradykinin stimulates interleukin-6 and interleukin-8 secretion of human decidua derived cells.
abstract: Cytokines are known to participate in the process of parturition within a paracrine network in fetal membranes. Bradykinin can also contribute to this process, increasing the release of eicosanoids from decidua cells. In this study, we present evidence for a cross-link between bradykinin and the cytokines. Short and long term cultures of human decidua cells were incubated for 4 h and 24 h with and without bradykinin. IL-6 and IL-8 were determined in the supernatants by ELISA. Results show a large interindividual variability in the basal secretion of IL-6 and IL-8 and a clear increase in the secretion of both ILs in response to bradykinin. By this amplifying effect on cytokine secretion, bradykinin can initiate local and systemic effects of amniochorionitis.
authors.affiliation: I. Frauenklinik, Ludwig-Maximilians-Universität München, Klinikum Innenstadt, Munich, Germany.
authors.forename: J
authors.initials: J
authors.lastname: Rehbock
authors.forename: A
authors.initials: A
authors.lastname: Chondromatidou
authors.forename: P
authors.initials: P
authors.lastname: Buchinger
authors.forename: A
authors.initials: A
authors.lastname: Hermann
authors.forename: M
authors.initials: M
authors.lastname: Jochum
mesh_terms: D001920:Bradykinin / Q000494:pharmacology*; D002478:Cells, Cultured; D003656:Decidua / Q000378:metabolism*; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000378:metabolism*; D016209:Interleukin-8 / Q000378:metabolism*; D011247:Pregnancy
chemical_list: D015850:Interleukin-6; D016209:Interleukin-8; D001920:Bradykinin