Essential fatty acids, immune function, and exercise.
The immunologic response to exercise comprises numerous alterations within the immune system, but how these processes are regulated is still largely unknown. Exercise-related immunological changes include signs of inflammation, such as release of inflammatory mediators, activation of various white blood cell lines and complement, and induction of acute phase proteins. Nevertheless, signs of immunosuppression, such as decreased T and B cell function or impaired cytotoxic or phagocytic activity, can also be observed. Some data suggest that essential fatty acids help regulate inflammatory processes, modulating both cytokine release and the acute phase response. Positive effects of changing dietary essential fatty acids have been demonstrated in chronic inflammatory diseases. In contrast, little is known about the contribution of fatty acids to the exercise-induced immunologic reaction. Essential fatty acids may determine alterations within the immune system following exercise. Therefore, future studies are necessary to evaluate the influence of the fatty acid composition on the inflammatory or immunosuppressive component following heavy exertion.
König
D
D
Department of Rehabilitation, Prevention and Sports Medicine, Freiburg University Hospital, Germany.
Berg
A
A
Weinstock
C
C
Keul
J
J
Northoff
H
H
D000210:Acute-Phase Reaction / Q000209:etiology / Q000276:immunology; D000818:Animals; D016207:Cytokines / Q000378:metabolism; D004041:Dietary Fats / Q000008:administration & dosage / Q000494:pharmacology; D015232:Dinoprostone / Q000502:physiology; D015777:Eicosanoids / Q000502:physiology; D005228:Fatty Acids, Essential / Q000008:administration & dosage / Q000494:pharmacology / Q000502:physiology*; D005609:Free Radicals; D006801:Humans; D007107:Immune System / Q000502:physiology*; D007108:Immune Tolerance / Q000502:physiology; D007249:Inflammation / Q000178:diet therapy / Q000209:etiology / Q000276:immunology; D015227:Lipid Peroxidation; D008560:Membrane Fluidity; D008563:Membrane Lipids / Q000502:physiology; D018384:Oxidative Stress; D005082:Physical Exertion / Q000502:physiology*; D015398:Signal Transduction; D013314:Stress, Mechanical
D016207:Cytokines; D004041:Dietary Fats; D015777:Eicosanoids; D005228:Fatty Acids, Essential; D005609:Free Radicals; D008563:Membrane Lipids; D015232:Dinoprostone