Antinociceptive activity of chromophoric chain substituted hemicyaninocolourants.
Some of the chromophoric chain substituted hemicyaninocolourants (CCHCs) were synthesized and confirmed on the basis of nitrogen analysis. These were tested for their antinociceptive activity in albino rats against tail flick technique and sodium chloride induced writhing test. Test compounds were given in graded doses (10, 20 and 50 mg/kg, intraperitoneally) and compared with morphine and aspirin as standard controls. Two compounds CCHC-1 and CCHC-2 showed antinociceptive activity in a dose-dependent manner in both the experimental models. The compound CCHC-3 did not exhibit antinociceptive activity to any significant extent.
Gupta
R K
RK
Department of Pharmacology, Mahatma Gandhi Institute of Medical Sciences, Sevagram-Wardha.
Jha
R K
RK
D000700:Analgesics / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D000701:Analgesics, Opioid; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D001241:Aspirin / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D004396:Coloring Agents / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D003514:Cyclohexylamines / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D005260:Female; D007274:Injections, Intraperitoneal; D008297:Male; D009020:Morphine / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D009584:Nitrogen / Q000032:analysis; D010146:Pain / Q000139:chemically induced / Q000188:drug therapy*; D011804:Quinolines / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D012015:Reference Standards; D012965:Sodium Chloride / Q000008:administration & dosage / Q000633:toxicity; D013329:Structure-Activity Relationship; D013623:Tail
D000700:Analgesics; D000701:Analgesics, Opioid; D000894:Anti-Inflammatory Agents, Non-Steroidal; C107244:CCHC 1; C107245:CCHC 2; C107246:CCHC 3; D004396:Coloring Agents; D003514:Cyclohexylamines; D011804:Quinolines; D012965:Sodium Chloride; D009020:Morphine; D009584:Nitrogen; D001241:Aspirin