title: A quantitative structure activity study on a new class of highly potent antiinflammatory agents.
abstract: A structure-activity study was carried out for some new antiinflammatory compounds 2,3-dihydrobenzo-furan-2-ones, analogues of the natural product wortmannin (the mold metabolite), inhibitors of prostaglandin synthesis. The results show that lipophilicity and steric properties are very important in two testing models.
authors.affiliation: Department of Pharmaceutical Chemistry, School of Pharmacy, University of Thessaloniki, Greece.
authors.forename: H L
authors.initials: HL
authors.lastname: Dimitra
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use; D001169:Arthritis, Experimental / Q000188:drug therapy; D001572:Benzofurans / Q000138:chemical synthesis / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use; D002351:Carrageenan / Q000633:toxicity; D004195:Disease Models, Animal; D015195:Drug Design; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D008956:Models, Chemical; D011453:Prostaglandins / Q000096:biosynthesis*; D051381:Rats; D013329:Structure-Activity Relationship
chemical_list: D000893:Anti-Inflammatory Agents; D001572:Benzofurans; D011453:Prostaglandins; D002351:Carrageenan