Polymorphic changes of mannitol during freeze-drying: effect of surface-active agents.
The effect of polysorbate 80 on the crystalline properties of mannitol during freeze-drying was studied. Crystallinity and polymorphism play an important role in, e.g., the solubility and stability of freeze-dried products. Polysorbate 80 had an effect on both the polymorphism and the crystallinity of freeze-dried mannitol.
Haikala
R
R
Orion Pharma, Espoo, Finland.
Eerola
R
R
Tanninen
V P
VP
Yliruusi
J
J
D003460:Crystallization; D004355:Drug Stability; D005612:Freeze Drying; D008353:Mannitol / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D011136:Polysorbates / Q000494:pharmacology*; D012996:Solutions; D013499:Surface Properties; D013501:Surface-Active Agents / Q000494:pharmacology*; D014961:X-Ray Diffraction
D011136:Polysorbates; D012996:Solutions; D013501:Surface-Active Agents; D008353:Mannitol