Prediction of the three-dimensional structure of the human Fas receptor by comparative molecular modeling.
The Fas antigen, a cell surface receptor belonging to the tumor necrosis factor receptor (TNFR) superfamily, triggers programmed cell death (apoptosis) in the immune system. The three-dimensional structure of Fas and molecular details of the interaction between Fas and its ligand are currently unknown. A three-dimensional model of the Fas extracellular region was generated by comparative modeling. Inverse folding analysis suggested good sequence-structure compatibility of the model and thus reasonable accuracy. The model was analyzed in the light of information provided by studies on TNFR and CD40, another member of the TNFR family, and the Fas ligand binding site was predicted.
Bajorath
J
J
Bristol-Myers Squibb Pharmaceutical Research Institute, Seattle, WA 98121, USA.
Aruffo
A
A
D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D019013:CD40 Antigens / Q000737:chemistry / Q000235:genetics; D003198:Computer Simulation; D053222:Fas Ligand Protein; D006801:Humans; D008562:Membrane Glycoproteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D051379:Mice; D008958:Models, Molecular; D008969:Molecular Sequence Data; D011487:Protein Conformation; D017510:Protein Folding; D051381:Rats; D018124:Receptors, Tumor Necrosis Factor / Q000737:chemistry / Q000235:genetics; D017386:Sequence Homology, Amino Acid; D013816:Thermodynamics; D019014:fas Receptor / Q000378:metabolism
D019013:CD40 Antigens; C505661:FASLG protein, human; D053222:Fas Ligand Protein; C505658:Fasl protein, mouse; C505662:Faslg protein, rat; D008562:Membrane Glycoproteins; D018124:Receptors, Tumor Necrosis Factor; D019014:fas Receptor