title: [Reaction of cells of subcutaneous connective tissue to the activation and blockade of the peptidergic system].
abstract: Changes in the quantitative composition of subcutaneous connective tissue cells were examined after activation and blockade of the peripheral peptidergic system with capsaicin. The activating dose (5 mg/kg) of the agent was found to increase the quantity of mast cells in the subcutaneous connective tissue. Its toxic dose (200 mg/kg) elevated the histiocytic and fibroblastic index while the number of mast cells reduced. The same reaction was seen in surgically impaired tissue innervation. It is concluded that peptidergic capsaicin-sensitive neurons play a role in the development of neurogenic dystrophy and this process involves connective tissue cell elements.
authors.forename: N F
authors.initials: NF
authors.lastname: Vorob'eva
authors.forename: G G
authors.initials: GG
authors.lastname: Kniazev
authors.forename: V K
authors.initials: VK
authors.lastname: Spiridonov
authors.forename: E M
authors.initials: EM
authors.lastname: Zhukova
mesh_terms: D000818:Animals; D002211:Capsaicin / Q000494:pharmacology*; D003238:Connective Tissue / Q000187:drug effects* / Q000378:metabolism; D003239:Connective Tissue Cells; D008297:Male; D008407:Mast Cells / Q000187:drug effects* / Q000378:metabolism; D009479:Neuropeptides / Q000819:agonists* / Q000037:antagonists & inhibitors; D051381:Rats; D017208:Rats, Wistar
chemical_list: D009479:Neuropeptides; D002211:Capsaicin
vernacular_title: Reaktsiia kletok podkozhnoĭ soedinitel'noĭ tkani na aktivatsiiu i blokadu peptidergicheskoĭ sistemy.