[An immunohistochemical study of the expression of transcription factor Oct3/4 in mouse spermatogenesis].
The expression of POU-domain transcription factor Oct3/4 in the testis of adult mice has been studied using indirect immunofluorescence with highly specific antibodies. The protein is shown to be expressed in germ cells of seminiferous epithelium in a stage specific manner. The protein synthesis is initiated in mid-pachytene spermatocytes, increases to reach its peak during meiotic division. The Oct3/4 level remains augmented in early spermatids, but gradually declines during their further developmental advancement. These findings imply that Oct3/4 may have a regulatory function providing for the control of meiosis and/or terminal differentiation of spermatogenic cells.
Tomilin
A N
AN
Kostyleva
E I
EI
Drosdovskiĭ
M A
MA
Seralini
J E
JE
Vorob'ev
V I
VI
D000818:Animals; D004847:Epithelial Cells; D019084:Fluorescent Antibody Technique, Indirect; D005786:Gene Expression Regulation / Q000502:physiology*; D006238:Haploidy; D008297:Male; D008540:Meiosis / Q000502:physiology; D051379:Mice; D013091:Spermatogenesis / Q000502:physiology*; D013737:Testis / Q000166:cytology / Q000378:metabolism; D013997:Time Factors; D014157:Transcription Factors / Q000096:biosynthesis*
D014157:Transcription Factors
Immunogistokhimicheskoe issledovanie ékspressii transkriptsionnogo faktora Oct3/4 v spermatogeneze myshi.