[Vascular abnormalities].
Formerly, if one would decide to get some interest in vascular anomalies, one would be abashed by the multiplicity of classifications, the empiricism of treatments but mainly by the poverty of fundamental research due to the lack of animal models. Today progress in molecular Biology and imaging allow to establish a coherent classification of vascular anomalies. Thanks to the development of quantum physics, pulsed dye laser is very efficacious in the treatment of capillary malformations (port-wine stains). Plastic surgery and reconstructive microsurgery allow wide resection of venous and arteriovenous malformations in collaboration with interventional radiology. Finally, recent discoveries in molecular genetic will allow the creation of transgenic mice with vascular anomalies phenotypically similar to human malformations. So, in the near future, we will be able to test experimentally new therapeutic approaches but especially set up research protocols directed to a better understanding of the pathogenic mechanisms of these vascular anomalies.
Vanwijck
R
R
Centre des malformations vasculaires du service de Chirurgie plastique, Cliniques universitaires St Luc, U.C.L., Bruxelles.
D000818:Animals; D001165:Arteriovenous Malformations / Q000235:genetics / Q000473:pathology / Q000601:surgery; D001808:Blood Vessels / Q000002:abnormalities*; D005260:Female; D006391:Hemangioma / Q000473:pathology / Q000628:therapy; D006801:Humans; D008208:Lymphatic System / Q000002:abnormalities; D008297:Male; D051379:Mice; D008822:Mice, Transgenic; D019339:Port-Wine Stain / Q000235:genetics / Q000473:pathology; D015642:Radiology, Interventional / Q000379:methods; D014652:Vascular Diseases / Q000145:classification
Les anomalies vasculaires.