title: A randomized, controlled trial of linopirdine in the treatment of Alzheimer's disease.
abstract: OBJECTIVE
  We tested the efficacy and safety of linopirdine, a novel phenylindolinone, in the treatment of Alzheimer's disease.
  
  
  METHODS
  A multicentre, randomized, double-blind, parallel group, placebo-controlled trial of linopirdine (30 mg three times per day or placebo). Patients (n = 382, 55% male, 98% Caucasian, age range 51-95 years) with mild or moderate Alzheimer's disease, of whom 375 received at least one treatment dose were analysed. There were no important differences between the groups at baseline.
  
  
  RESULTS
  No difference was seen in Clinical Global Impression scores between patients receiving placebo and those receiving linopirdine (n = 189). Small differences in the Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-Cog) scores were seen throughout the study favouring linopirdine; at 6 months the ADAS-Cog scores were 20.2 (linopirdine) and 22.1 (placebo) p = 0.01.
  
  
  CONCLUSIONS
  This trial did not detect clinically meaningful differences in patients receiving linopirdine for 6 months, despite evidence of a small degree of improved cognitive function. Further studies may benefit from more sensitive tests of treatment effects in Alzheimer's disease.
authors.affiliation: Division of Geriatric Medicine, Dalhousie University, Halifax, Nova Scotia.
authors.forename: K
authors.initials: K
authors.lastname: Rockwood
authors.forename: B L
authors.initials: BL
authors.lastname: Beattie
authors.forename: M R
authors.initials: MR
authors.lastname: Eastwood
authors.forename: H
authors.initials: H
authors.lastname: Feldman
authors.forename: E
authors.initials: E
authors.lastname: Mohr
authors.forename: W
authors.initials: W
authors.lastname: Pryse-Phillips
authors.forename: S
authors.initials: S
authors.lastname: Gauthier
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000188:drug therapy* / Q000523:psychology; D003071:Cognition / Q000187:drug effects; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007211:Indoles / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D011725:Pyridines / Q000627:therapeutic use*
chemical_list: D007211:Indoles; D011725:Pyridines; C061017:linopirdine