[The system of hemostasis in experimental liver transplantation].
The status of haemostatic factors in 28 pigs after orthotopic liver transplantation was evaluated. The major changes took place in fibrinolytic system during the "non-liver" stage: rapid increase of fibrinolytic activity, plasmin activity, plasmin activator activity. From the moment of blood supply restoration to a transplanted liver the tendency to normalisation of fibrinolysis was detected. The deficiency of plasma haemostatic factors and platelets has increased during all the follow-up period and should be corrected in time. The following principles of corrective therapy are formulated: inhibition of fibrinolysis, correction of antithrombin-3 and blood clotting factors. Correction of haemostasis should be done in "pre-non-liver" period and later in "non-liver" reperfusion periods.
Zhidkov
I L
IL
Scientific Center of Surgery, Moscow.
Michailov
I E
IE
Broun
N K
NK
Smirnova
L A
LA
Buianov
V V
VV
Eramishantsev
A K
AK
D000818:Animals; D000990:Antithrombin III / Q000378:metabolism; D001778:Blood Coagulation Disorders / Q000097:blood* / Q000188:drug therapy / Q000209:etiology; D001779:Blood Coagulation Factors / Q000378:metabolism; D005260:Female; D005341:Fibrinolysin / Q000378:metabolism; D005343:Fibrinolytic Agents / Q000627:therapeutic use; D005500:Follow-Up Studies; D006487:Hemostasis / Q000187:drug effects / Q000502:physiology*; D016031:Liver Transplantation / Q000009:adverse effects; D008297:Male; D011183:Postoperative Complications; D013552:Swine; D013556:Swine, Miniature; D015912:Thrombolytic Therapy / Q000379:methods
D001779:Blood Coagulation Factors; D005343:Fibrinolytic Agents; D000990:Antithrombin III; D005341:Fibrinolysin
Sistema gemostaza transplantatsii pecheni v eksperimente.