Clinical and immunogenetic investigation of a Laotian patient with Vogt-Koyanagi-Harada's disease.
Vogt-Koyanagi-Harada's (VKH) disease has been known to be associated with HLA class II antigen, HLA-DR4 and -DR53. Recent recombinant DNA technical advances have allowed us to investigate the genetic polymorphism of HLA antigens at the molecular level. By use of the polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) technique we have found that VKH disease is closely associated with HLA-DRB1*04 (DRB1*0405/ DRB1*0410) and DQB1*04 (DQB1*0401/DQB1*0402) in the Japanese. Here, we will describe a typical case of a Laotian patient with VKH disease and the results of HLA typing: the patient showed a conservation of one of the major haplotypes observed in Japanese VKH patients, DRB1*0405-DQB1*0402.
Shindo
Y
Y
Department of Ophthalmology, Yokohama City University School of Medicine, Japan.
Inoko
H
H
Nakamura
S
S
Onoe
K
K
Inoue
T
T
Ohno
S
S
D000328:Adult; D004198:Disease Susceptibility; D005260:Female; D005451:Fluorescein Angiography; D005654:Fundus Oculi; D005802:Genes, MHC Class II / Q000235:genetics* / Q000276:immunology; D005838:Genotype; D006683:HLA-DQ Antigens / Q000235:genetics / Q000276:immunology; D006684:HLA-DR Antigens / Q000235:genetics / Q000276:immunology; D006650:Histocompatibility Testing; D006801:Humans; D007812:Laos / Q000208:ethnology; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D014607:Uveomeningoencephalitic Syndrome / Q000208:ethnology / Q000235:genetics* / Q000276:immunology
D006683:HLA-DQ Antigens; D006684:HLA-DR Antigens