Cumulative conception and live birth rates after oocyte donation: implications regarding endometrial receptivity.
The purpose of the present study was to determine the cumulative likelihood of pregnancy success after repetitive cycles of oocyte donation and specifically to examine the influence of recipient age and diagnosis upon the cumulative likelihood of pregnancy in an effort to identify any potential subgroup of recipients who might have diminished endometrial receptivity. We retrospectively analysed the outcome of 418 consecutive embryo transfer cycles among 276 recipients of oocyte donation in our institution. We analysed clinical pregnancy and delivery rates in the recipients divided by age groups and diagnostic groups. For the purpose of life-table analysis, only cycles prior to and including the first cycle producing a successful pregnancy were included. Frozen-thawed embryo transfers were not included in the analysis. The overall clinical pregnancy rate was 36.2% (95% CI 31-41%) and the cumulative pregnancy rate after four cycles was 87.9%. The overall delivery rate was 29.3% (95% CI 25-33%) and the cumulative delivery rate after four cycles was 86.1%. There were no statistically significant differences in any of the rates attributable to recipient age or diagnosis. No decline in per cycle success was noted over consecutive cycles. We conclude that neither recipient age nor diagnosis plays a substantial role in the success of oocyte donation, implying that endometrial receptivity is unaltered by age or diagnosis. Furthermore, up to four successive cycles of oocyte donation are associated with the same probability of success.
Paulson
R J
RJ
Department of Obstetrics and Gynecology, University of Southern School of Medicine and USC IVF, California Medical Center, Los Angeles, USA.
Hatch
I E
IE
Lobo
R A
RA
Sauer
M V
MV
D000328:Adult; D000375:Aging / Q000502:physiology*; D001723:Birth Rate; D004624:Embryo Transfer; D004717:Endometrium / Q000502:physiology*; D005260:Female; D005306:Fertilization / Q000502:physiology*; D006801:Humans; D007247:Infertility, Female / Q000209:etiology; D015993:Life Tables; D016013:Likelihood Functions; D008875:Middle Aged; D018587:Oocyte Donation; D011247:Pregnancy; D018873:Pregnancy Rate; D012189:Retrospective Studies