Protective effect of magnesium supplementation on experimental 3-methyl cholanthrene-induced fibrosarcoma and changes in tissue magnesium distribution during carcinogenesis in rats.
In this study, we wanted to examine the effect of magnesium (Mg2+) supplementation on the experimental 3-methyl cholanthrene (3-MC)-induced fibrosarcoma and alterations in (Mg2+) distribution in several tissues of the rats, during carcinogenesis. It was determined that serum and tissue (Mg2+) levels of the rats in (Mg2+)-supplemented diet group were higher than those of the rats in the (Mg2+)-nonsupplemented and control groups. The mean time of fibrosarcoma development for (Mg2+)-supplemented group was longer than (Mg2+)-nonsupplemented group (p < 0.05). Symptoms of hypermagnesemia were not observed in any of the rats. These results suggests that dietary (Mg2+) supplementation may have a partial anti-carcinogenic effect on experimental 3-MC-induced fibrosarcoma by prolongation of the latent period of carcinogenesis.
Patiroğlu
T
T
Erciyes University Medical Faculty, Department of Pediatrics, Kayseri, Türkiye.
Sahin
G
G
Kontaş
O
O
Uzüm
K
K
Saraymen
R
R
D000818:Animals; D016588:Anticarcinogenic Agents / Q000737:chemistry / Q000493:pharmacokinetics / Q000627:therapeutic use; D005354:Fibrosarcoma / Q000139:chemically induced* / Q000178:diet therapy* / Q000378:metabolism; D005527:Food, Fortified; D008274:Magnesium / Q000737:chemistry / Q000493:pharmacokinetics* / Q000494:pharmacology*; D008748:Methylcholanthrene; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution / Q000187:drug effects
D016588:Anticarcinogenic Agents; D008748:Methylcholanthrene; D008274:Magnesium