title: AIDS: decline and fall of immune surveillance?
abstract: Recent observations cast doubt on the view that cytotoxic T cells play a key role in keeping HIV-1 infection in check, and that it is the decline in this mechanism of immune surveillance that permits progression to AIDS.
authors.affiliation: Office of AIDS Research, National Institutes of Health, Building 3,1 Room 4C06, 31 Center Drive, Bethesda, Maryland 20892, USA. mbf@helix.nih.gov
authors.forename: M B
authors.initials: MB
authors.lastname: Feinberg
authors.forename: A R
authors.initials: AR
authors.lastname: McLean
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology* / Q000821:virology; D019380:Anti-HIV Agents / Q000494:pharmacology / Q000627:therapeutic use; D018450:Disease Progression; D015658:HIV Infections / Q000188:drug therapy / Q000276:immunology / Q000473:pathology / Q000821:virology; D015497:HIV-1 / Q000187:drug effects / Q000276:immunology / Q000502:physiology; D006801:Humans; D007157:Immunologic Surveillance; D018448:Models, Immunological; D012367:RNA, Viral / Q000097:blood; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D014766:Viremia / Q000188:drug therapy / Q000821:virology; D014779:Virus Replication
chemical_list: D019380:Anti-HIV Agents; D012367:RNA, Viral