[Effect of cold stress on the contractile activity, carbohydrate and energy metabolism in the isolated rat heart].
Acute cold stress (-20 degrees C for 4 hours) in rats causes profound contractile changes in the heart isolated and perfused by the Langendorf method. This reduced contraction amplitudes and increased heart rates. The decreased contraction amplitudes was associated with inadequate ATP formation. While changing perfusion of post-stress isolated heart, myocardial rigidity slowed down, which seemed to be associated with activated glycolysis. There were no signs of cardiomyocytic lesion after cold stress. Reduced coronary flow is the only abnormal effect of acute cold stress under these conditions. High cardiac resistance to the damaging effect of cold is likely to be related to increased processes of glycolysis and glycogenolysis in the cardiomyocytes.
Lishmanov
Iu B
IuB
Lasukova
T V
TV
Afanas'ev
S A
SA
Maslov
L N
LN
Krotenko
N M
NM
Naryzhnaia
N V
NV
D000818:Animals; D050260:Carbohydrate Metabolism; D003080:Cold Temperature; D004734:Energy Metabolism / Q000502:physiology*; D066298:In Vitro Techniques; D008297:Male; D009200:Myocardial Contraction / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D013312:Stress, Physiological / Q000378:metabolism / Q000503:physiopathology*
Vliianie kholodovogo stressa na sokratitel'nuiu aktivnost', uglevodnyĭ i énergeticheskiĭ metabolizm izolirovannogo serdtsa krys.