Histone acetylation: chromatin in action.
Histone acetylation acts as a landmark and determinant for chromatin function. Active roles in the transcription and assembly of chromatin have been discovered for histone acetyltransferases and deacetylases. This review highlights these roles and discusses their significance for the maintenance of cell differentiation.
Wade
P A
PA
Laboratory of Molecular Embryology, National Institute of Child Health and Human Development, NIH, Bethesda, MD 20892-5431, USA. awlme@helix.nih.gov
Pruss
D
D
Wolffe
A P
AP
D000107:Acetylation; D000123:Acetyltransferases / Q000235:genetics / Q000378:metabolism; D002453:Cell Cycle / Q000235:genetics*; D002454:Cell Differentiation / Q000235:genetics; D002843:Chromatin / Q000235:genetics / Q000378:metabolism*; D051548:Histone Acetyltransferases; D006657:Histones / Q000235:genetics / Q000378:metabolism*; D008938:Mitosis; D029701:Saccharomyces cerevisiae Proteins; D014158:Transcription, Genetic
D002843:Chromatin; D006657:Histones; D029701:Saccharomyces cerevisiae Proteins; D000123:Acetyltransferases; D051548:Histone Acetyltransferases