[The ultrastructure of the synapses in the upper layers of the cat cerebral cortex after applying strychnine].
Ultrastructure of axo-dendritic and axo-spinous synapses in upper layers of cat brain gyrus suprasylvii was studied in 10, 30 and 90 min application of 0.1% strychnine nitrate and also 2.5 and 5 hrs after 90 min long use of strychnine. Portion of active synaptic contacts was found to grow higher in 10 and 30 min application and smaller during and 2.5 hrs after 90 min application. However, synaptic vesicles number is sharply reduced beginning from min 30 of application and only on 5th postapplication hr reaches initial level. Application of strychnine does not cause changes in synapse active zone length and presynaptic terminals section area. Reorganisations in pre- and postsynaptic terminals most acutely manifested in 90 min application are reversible--on 5th postapplication hr synapse ultrastructure turns into similar to that of control material.
Kutateladze
I I
II
Lazriev
I L
IL
D000818:Animals; D002415:Cats; D002540:Cerebral Cortex / Q000187:drug effects* / Q000648:ultrastructure*; D003292:Convulsants / Q000494:pharmacology*; D003712:Dendrites / Q000187:drug effects / Q000648:ultrastructure; D004569:Electroencephalography / Q000187:drug effects; D008854:Microscopy, Electron; D017729:Presynaptic Terminals / Q000187:drug effects / Q000648:ultrastructure; D013331:Strychnine / Q000494:pharmacology*; D013569:Synapses / Q000187:drug effects* / Q000648:ultrastructure*; D013997:Time Factors
D003292:Convulsants; D013331:Strychnine
Ul'trastruktura sinapsov verkhnikh sloev kory bol'shogo mozga koshki posle applikatsii strikhnina.