High serum level of soluble CD30 in acute primary HIV-1 infection.
CD30 has been suggested to play a role in HIV infection. In this study the serum concentration of soluble CD30 (sCD30) was determined by an ELISA essay on samples collected from patients with acute primary HIV-1 infection during the acute phase (n = 17) and after seroconversion (n = 13). sCD30 during acute infection was consistently elevated (137.58 +/- 120.33 versus 6.4 +/- 5.4 U/ml (mean +/- s.d.) in normal controls, P<0.0001) and decreased after seroconversion (49.1 +/- 66.17 U/ml; P = 0.0018 compared with acute infection). This trend mirrored the disappearance of detectable levels of HIV antigen in the blood, resulting in a direct correlation between sCD30 and HIVAg values (P = 0.002). These data suggest that the high levels of sCD30 observed during the peak concentration of HIVAg in acute primary HIV infection might reflect the high rate of viral replication.
Pizzolo
G
G
Department of Haematology, Policlinico Borgo Roma, Verona University School of Medicine, Italy.
Vinante
F
F
Nadali
G
G
Krampera
M
M
Morosato
L
L
Chilosi
M
M
Raiteri
R
R
Sinicco
A
A
D000208:Acute Disease; D000328:Adult; D005260:Female; D015488:HIV Antigens / Q000097:blood; D015658:HIV Infections / Q000097:blood / Q000276:immunology* / Q000821:virology; D015497:HIV-1 / Q000276:immunology; D006801:Humans; D017730:Ki-1 Antigen / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012995:Solubility
D015488:HIV Antigens; D017730:Ki-1 Antigen