Interferon treatment of porphyria cutanea tarda associated with chronic hepatitis type C.
We evaluated the efficacy of interferon in the treatment of a 61 year-old male patient with porphyria cutanea tarda associated with hepatitis C virus infection. After initiation of intravenous administration of interferon-beta, urinary excretion of uroporphyrin and coproporphyrin, serum transaminase, gamma-glutamyl transpeptidase levels and ferritin were gradually increased. However, after completion of interferon-beta administration for 6 weeks, urinary excretion of uroporphyrin and coproporphyrin, serum enzymes and ferritin were significantly decreased correspondent with diminished hepatitis C virus RNA titer. These results suggest that interferon may be beneficial for the treatment of porphyria cutanea tarda due to hepatitis C virus infection.
Okano
J
J
Second Department of Internal Medicine, Tottori, University School of Medicine, Yonago, Japan.
Horie
Y
Y
Kawasaki
H
H
Kondo
M
M
D000410:Alanine Transaminase / Q000097:blood; D000998:Antiviral Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001219:Aspartate Aminotransferases / Q000097:blood; D003306:Coproporphyrins / Q000652:urine; D005293:Ferritins / Q000097:blood; D016174:Hepacivirus / Q000235:genetics; D006526:Hepatitis C / Q000150:complications* / Q000628:therapy; D006521:Hepatitis, Chronic / Q000150:complications* / Q000628:therapy; D006801:Humans; D007275:Injections, Intravenous; D016899:Interferon-beta / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D017119:Porphyria Cutanea Tarda / Q000628:therapy* / Q000821:virology; D012367:RNA, Viral / Q000032:analysis; D014578:Uroporphyrins / Q000652:urine; D005723:gamma-Glutamyltransferase / Q000097:blood
D000998:Antiviral Agents; D003306:Coproporphyrins; D012367:RNA, Viral; D014578:Uroporphyrins; D016899:Interferon-beta; D005293:Ferritins; D005723:gamma-Glutamyltransferase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase