Deficits in water escape performance and alterations in hippocampal cholinergic mechanisms associated with neonatal monosodium glutamate treatment in mice.
Mice treated neonatally with monosodium glutamate (MSG) were found to have learning and memory deficits in performing a non-spatial water escape task. Scopolamine impaired the water-escape performance of the control mice but not that of the MSG-treated mice. It was suggested that the water-escape performance deficit in the MSG-treated mice was a result of impaired central cholinergic mechanisms. As such, scopolamine was unable to further incapacitate an already impaired cholinergic system. This is strongly supported by the decreased affinity of the sodium-dependent high-affinity choline uptake observed in the hippocampus. D-Cycloserine, a partial agonist at the glycine site of the NMDA receptor, did not affect the water-escape performance of the MSG-treated and control mice; nor did it alter the effects of scopolamine. This lack of effect of D-Cycloserine may imply that the NMDA receptors are not involved in non-spatial learning, in contrast to their reported involvement in spatial learning.
Wong
P T
PT
Department of Pharmacology, Faculty of Medicine, National University of Singapore, Kent Ridge, Singapore.
Neo
L H
LH
Teo
W L
WL
Feng
H
H
Xue
Y D
YD
Loke
W H
WH
D000818:Animals; D000831:Animals, Newborn; D002794:Choline / Q000378:metabolism; D018678:Cholinergic Agents / Q000494:pharmacology*; D003523:Cycloserine / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical; D004924:Escape Reaction / Q000187:drug effects*; D005260:Female; D006624:Hippocampus / Q000187:drug effects*; D008297:Male; D051379:Mice; D011597:Psychomotor Performance / Q000187:drug effects*; D011930:Reaction Time / Q000187:drug effects; D017470:Receptors, Glutamate / Q000378:metabolism; D011976:Receptors, Muscarinic / Q000378:metabolism; D012601:Scopolamine / Q000494:pharmacology; D012970:Sodium Glutamate / Q000494:pharmacology*; D013237:Stereoisomerism
D018678:Cholinergic Agents; D017470:Receptors, Glutamate; D011976:Receptors, Muscarinic; D003523:Cycloserine; D012601:Scopolamine; D002794:Choline; D012970:Sodium Glutamate