Effect of atenolol on birth weight.
To investigate the possible harmful effects of early antihypertensive drug therapy with atenolol versus other therapies on pregnancy outcome, we reviewed the records of 398 women referred to our antenatal hypertension clinic between 1980 and 1995. Babies born to women taking atenolol were significantly lighter than babies born to women taking other beta blockers, other antihypertensive drugs, or no therapy, suggesting that atenolol might be detrimental in early pregnancy.
Lip
G Y
GY
University Department of Medicine, City Hospital, Birmingham, England.
Beevers
M
M
Churchill
D
D
Shaffer
L M
LM
Beevers
D G
DG
D000704:Analysis of Variance; D000886:Anthropometry; D000959:Antihypertensive Agents / Q000009:adverse effects*; D001262:Atenolol / Q000009:adverse effects*; D001724:Birth Weight / Q000187:drug effects*; D005260:Female; D005317:Fetal Growth Retardation / Q000139:chemically induced; D005865:Gestational Age; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D009929:Organ Size / Q000187:drug effects; D010920:Placenta; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000188:drug therapy*; D011446:Prospective Studies; D012044:Regression Analysis
D000959:Antihypertensive Agents; D001262:Atenolol