title: The effect of assessment method and respondent population on utilities elicited for Gaucher disease.
abstract: Measured preferences have been reported to vary with the method of elicitation and respondent population surveyed. We elicited utilities for Gaucher disease using a multimedia implementation of the time trade-off, standard gamble, and a conceptually different, largely untested approach, the risk-risk trade-off, from those who are healthy, those with a chronic illness and those with Gaucher disease. The risk-risk trade-off produced significantly lower utilities than the other two preference assessment methods and had the poorest test-retest reliability. The respondent's self-rated current health state utility was the most important determinant of utility values elicited by the time trade-off and standard gamble for the hypothetical health states. Our results do not support the use of our implementation of the risk-risk trade-off method. In eliciting preferences for hypothetical health states from the general population, the subjective rating of a respondent's own health state should be considered in determining representative population groups.
authors.affiliation: Department of Medicine, Montreal General Hospital, Quebec, Canada.
authors.forename: A E
authors.initials: AE
authors.lastname: Clarke
authors.forename: M K
authors.initials: MK
authors.lastname: Goldstein
authors.forename: D
authors.initials: D
authors.lastname: Michelson
authors.forename: A M
authors.initials: AM
authors.lastname: Garber
authors.forename: L A
authors.initials: LA
authors.lastname: Lenert
mesh_terms: D000328:Adult; D000465:Algorithms; D016001:Confidence Intervals; D003362:Cost-Benefit Analysis; D003661:Decision Support Techniques; D005260:Female; D005776:Gaucher Disease / Q000523:psychology*; D006305:Health Status Indicators; D006801:Humans; D008297:Male; D008875:Middle Aged; D019212:Multimedia; D011788:Quality of Life; D019057:Quality-Adjusted Life Years; D015203:Reproducibility of Results; D012309:Risk-Taking; D018709:Statistics, Nonparametric