title: A novel human papillomavirus identified in epidermodysplasia verruciformis.
abstract: Epidermodysplasia verruciformis (EV) is a rare inherited condition in which there is widespread infection with human papillomavirus (HPV). Patients have a high risk of developing squamous cell carcinoma and Bowen's disease on sun-exposed sites. We describe a Jamaican man with the typical clinical and histopathological features of EV.HPV 8, 24 and a subtype of HPV 38, along with a novel HPV sequence most closely related to HPV 9 have been detected in his skin lesions. Although skin tumours are rare in black patients with EV and he has lived in a temperate climate most of his life, several of the lesions showed bowenoid atypia and he is at risk of developing invasive cutaneous malignancies.
authors.affiliation: Department of Dermatology, Stoke Mandeville Hospital NHS Trust, Aylesbury, U.K.
authors.forename: A J
authors.initials: AJ
authors.lastname: Harris
authors.forename: K
authors.initials: K
authors.lastname: Purdie
authors.forename: I M
authors.initials: IM
authors.lastname: Leigh
authors.forename: C
authors.initials: C
authors.lastname: Proby
authors.forename: S
authors.initials: S
authors.lastname: Burge
mesh_terms: D004819:Epidermodysplasia Verruciformis / Q000473:pathology / Q000821:virology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D027383:Papillomaviridae / Q000145:classification* / Q000302:isolation & purification; D030361:Papillomavirus Infections / Q000150:complications*; D011230:Precancerous Conditions / Q000821:virology; D012878:Skin Neoplasms / Q000821:virology; D014412:Tumor Virus Infections / Q000150:complications*