title: T-cell-rich B-cell lymphoma in a cat.
abstract: T-cell-rich B-cell lymphoma is a neoplasm recognized in humans in which a neoplastic proliferation of large B lymphocytes is present amid a background of reactive T lymphocytes. A 13-year-old Domestic Shorthair cat developed a mass in the region of the left parotid gland. Histologically, the mass was composed of scattered large atypical cells within a dense background of uniform small lymphoid cells. Immunohistochemically, the large cells were uniformly labeled using antiserum directed against the B-lymphocyte marker BLA.36, whereas labeling of nearly all of the small cells was limited to the T-lymphocyte marker CD3. The histomorphologic and immunohistochemical features of this unique feline neoplasm are characteristic of T-cell-rich B-cell lymphoma of humans.
authors.affiliation: Pathology Division, USAMRIID, Fort Detrick, Frederick, MD 21702-5011, USA.
authors.forename: K E
authors.initials: KE
authors.lastname: Steele
authors.forename: G K
authors.initials: GK
authors.lastname: Saunders
authors.forename: G D
authors.initials: GD
authors.lastname: Coleman
mesh_terms: D000818:Animals; D002371:Cat Diseases / Q000473:pathology*; D002415:Cats; D016393:Lymphoma, B-Cell / Q000473:pathology* / Q000662:veterinary*; D010307:Parotid Neoplasms / Q000473:pathology* / Q000662:veterinary*; D013601:T-Lymphocytes / Q000473:pathology*