[Effect of oxygen in different concentrations and free radical-anti-radical activity system in patients with chronic pulmonary insufficiency].
The study of free-radical processes elucidated concentrations of O2 producing a negative effect in chronic obstructive bronchitis sufferers with respiratory insufficiency (RI). In RI of the second and third degree concentration of inhaled O2 should not exceed 50%. In this concentration O2 toxicity is not evident, unbalance of the system free radical-antiradical activity is less pronounced, O2 transport from the lungs to the tissue reaches optimal level. A course of oxygen therapy (20 daily sessions lasting 30 min., 50% O2) is not toxic, promoted activation of SOD and alleviation of arterial hypoxemia.
Aleksandrov
O V
OV
Department of Internal Diseases of MBF RGMU, Moscow.
Vinitskaia
R S
RS
Naumenko
Z K
ZK
Nekliudova
G V
GV
D001784:Blood Gas Analysis; D002908:Chronic Disease; D004305:Dose-Response Relationship, Drug; D005609:Free Radicals / Q000378:metabolism; D006801:Humans; D010100:Oxygen / Q000008:administration & dosage* / Q000009:adverse effects; D010101:Oxygen Consumption; D010102:Oxygen Inhalation Therapy / Q000009:adverse effects / Q000379:methods*; D012131:Respiratory Insufficiency / Q000378:metabolism / Q000628:therapy*; D013482:Superoxide Dismutase / Q000378:metabolism
D005609:Free Radicals; D013482:Superoxide Dismutase; D010100:Oxygen
Vozdeistvie kisloroda raznoi kontsentratsii na sistemu svobodnoradikal'naia-antiradikal'naia aktivnost' u bol'nykh khronicheskoi legochnoi nedostatochnost'iu.