Urinary bladder-urethral sphincter dysfunction in mice with targeted disruption of neuronal nitric oxide synthase models idiopathic voiding disorders in humans.
Idiopathic voiding disorders affect up to 10-15% of men and women. We describe bladder abnormalities in mice with targeted deletion of the gene for neuronal nitric oxide synthase which model the clinical disorders. The mice possess hypertrophic dilated bladders and dysfunctional urinary outlets which do not relax in response to electrical field stimulation or L-arginine. The mice also display increased urinary frequency.
Burnett
A L
AL
Department of Urology, College of Arts and Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
Calvin
D C
DC
Chamness
S L
SL
Liu
J X
JX
Nelson
R J
RJ
Klein
S L
SL
Dawson
V L
VL
Dawson
T M
TM
Snyder
S H
SH
D000818:Animals; D001120:Arginine / Q000494:pharmacology; D004195:Disease Models, Animal; D004558:Electric Stimulation; D004730:Endothelium, Vascular / Q000737:chemistry; D006801:Humans; D006984:Hypertrophy; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009119:Muscle Contraction / Q000187:drug effects; D009474:Neurons / Q000201:enzymology; D009569:Nitric Oxide / Q000502:physiology; D019001:Nitric Oxide Synthase / Q000032:analysis / Q000235:genetics / Q000502:physiology*; D009599:Nitroprusside / Q000494:pharmacology; D014521:Urethra / Q000737:chemistry / Q000503:physiopathology*; D001743:Urinary Bladder / Q000737:chemistry / Q000294:innervation / Q000503:physiopathology*; D014555:Urination Disorders / Q000503:physiopathology*; D019459:Urothelium / Q000737:chemistry
D009599:Nitroprusside; D009569:Nitric Oxide; D001120:Arginine; D019001:Nitric Oxide Synthase