Genetic linkage and bipolar affective disorder: progress and pitfalls.
The history of linkage studies in bipolar affective disorder is a convoluted affair punctuated by upswings and setbacks, hope and skepticism. Advances in genomics and statistical techniques, and the availability of well-characterized clinical samples, have bolstered the search for disease genes, leading to a new crop of findings. Indeed, recent reports of putative loci on chromosomes 18, 21, X, 4, 6, 13 and 15 have rekindled a sense of optimism. The new findings are reviewed and scrutinized, with implications for future research.
Baron
M
M
Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA. mb17@columbia.edu
D001714:Bipolar Disorder / Q000235:genetics*; D008040:Genetic Linkage / Q000235:genetics*; D006801:Humans