Listeriosis after fludarabine treatment for chronic lymphocytic leukemia.
The authors report a case of Listeria monocytogenes septicemia in a patient with advanced CLL after a single course of fludarabine, without any other immunosuppressive therapy e.g. corticosteroids. The immunosuppressive action of fludarabine in patients who are already severely immunosuppressed must be considered from a diagnostic and therapeutic point of view. Listeriosis and other opportunistic infections, like pneumocystis carinii pneumonia, have been reported during and after treatment with purine analogues. Prophylaxis with cotrimoxazole must therefore be discussed in patients with CLL treated with fludarabine.
Hequet
O
O
Department of Oncology/Haematology, HIA Sainte-Anne, Toulon Naval, France.
de Jaureguiberry
J P
JP
Jaubert
D
D
Gisserot
O
O
Muzellec
Y
Y
Brisou
P
P
D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects*; D002699:Chlorambucil / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000627:therapeutic use; D004317:Doxorubicin / Q000627:therapeutic use; D005260:Female; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000097:blood / Q000150:complications* / Q000188:drug therapy; D008088:Listeriosis / Q000097:blood / Q000139:chemically induced* / Q000188:drug therapy; D011241:Prednisone / Q000627:therapeutic use; D013420:Sulfamethoxazole / Q000008:administration & dosage / Q000627:therapeutic use; D014295:Trimethoprim / Q000008:administration & dosage / Q000627:therapeutic use; D014740:Vidarabine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D014750:Vincristine / Q000627:therapeutic use
D000970:Antineoplastic Agents; D002699:Chlorambucil; D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D014295:Trimethoprim; D014740:Vidarabine; D013420:Sulfamethoxazole; C024352:fludarabine; D011241:Prednisone