Comparative in vitro activities of DU-6859a, levofloxacin, ofloxacin, sparfloxacin, and ciprofloxacin against 387 aerobic and anaerobic bite wound isolates.
The activities of DU-6859a, levofloxacin, ofloxacin, sparfloxacin, and ciprofloxacin against bite wound isolates were determined by the agar dilution method. DU-6859a was the most active compound (MICs, < or = 0.125 microg/ml) against all Pasteurella species, Staphylococcus aureus, and streptococci; anaerobes were susceptible to < or = 0.5 microg/ml, except fusobacteria, which were susceptible to < or = 2 microg/ml. Against aerobes, levofloxacin was more active than ofloxacin (MIC at which 90% of isolates are inhibited [MIC90], < or = 1.0 microg/ml for both) and sparfloxacin and ciprofloxacin were also active (MIC90s, < or = 0.25 and < 1 microg/ml, respectively).
Goldstein
E J
EJ
R. M. Alden Research Laboratory, Santa Monica-UCLA Medical Center, California 90404, USA.
Citron
D M
DM
Hunt Gerardo
S
S
Hudspeth
M
M
Merriam
C V
CV
D000818:Animals; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D001420:Bacteria, Aerobic / Q000187:drug effects*; D001421:Bacteria, Anaerobic / Q000187:drug effects*; D001733:Bites and Stings / Q000382:microbiology*; D002415:Cats; D002939:Ciprofloxacin / Q000627:therapeutic use; D004285:Dogs; D024841:Fluoroquinolones; D000882:Haplorhini; D006801:Humans; D064704:Levofloxacin; D008826:Microbial Sensitivity Tests; D015242:Ofloxacin / Q000627:therapeutic use; D015363:Quinolones / Q000627:therapeutic use; D013552:Swine; D014946:Wound Infection / Q000188:drug therapy* / Q000382:microbiology
D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D015363:Quinolones; D002939:Ciprofloxacin; D064704:Levofloxacin; D015242:Ofloxacin; C061363:sparfloxacin