Relationship between pharmacokinetics and the analgesic effect of indomethacin in the rat.
The relationship between the pharmacokinetic properties and the analgesic effect of indomethacin (IDM) was evaluated on a carrageenin-induced inflammation model in the rat. Rats were administered the drug in one of two ways: intravenous (i.v.) IDM bolus or i.v. IDM infusion. The analgesic activity was measured by Randall-Selitto test. No correlation was observed between the analgesic effect and the plasma IDM concentration after i.v. bolus administration of IDM. However, in the case of infusion, IDM produced a dose-dependent analgesic effect. In this paper, we demonstrated that the plasma concentration of IDM maintained by i.v. infusion had a prolonged analgesic effect on the carrageenin-induced inflammation model.
Suzuki
T
T
Department of Pharmaceutical Science, College of Pharmacy, Nihon University, Chiba, Japan.
Suganuma
T
T
Shimizu
R
R
Aoki
M
M
Hanano
M
M
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000494:pharmacology*; D002351:Carrageenan / Q000633:toxicity; D004487:Edema / Q000139:chemically induced / Q000503:physiopathology*; D005260:Female; D006614:Hindlimb; D007213:Indomethacin / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000494:pharmacology*; D007262:Infusions, Intravenous; D007275:Injections, Intravenous; D010147:Pain Measurement / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar
D000894:Anti-Inflammatory Agents, Non-Steroidal; D002351:Carrageenan; D007213:Indomethacin