Inhibitory effects of quassinoid derivatives on Epstein-Barr virus early antigen activation.
Short-term in vitro assays for tumor promoters and antitumor promoters (Epstein-Barr virus activation test) were carried out for semisynthetic quassinoids (3-7), which were obtained by esterification of the C-15 OH group of deacetylated isobrucein-B (2). All the ester derivatives showed higher antitumor promoting activity than that of the potent compound 2. A compound containing a fluorinated aliphatic ester showed the highest potency.
Rahman
S
S
Department of Interdisciplinary Studies on Natural Environment, Faculty of Integrated Arts and Sciences, Hiroshima University, Higashi-Hiroshima, Japan.
Fukamiya
N
N
Ohno
N
N
Tokuda
H
H
Nishino
H
H
Tagahara
K
K
Lee
K H
KH
Okano
M
M
D000956:Antigens, Viral / Q000187:drug effects* / Q000276:immunology; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000494:pharmacology; D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology; D005900:Glaucarubin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D004854:Herpesvirus 4, Human; D036702:Quassins; D014407:Tumor Cells, Cultured; D014775:Virus Activation / Q000187:drug effects
D000956:Antigens, Viral; D000972:Antineoplastic Agents, Phytogenic; D000998:Antiviral Agents; C033305:Epstein-Barr virus early antigen; D036702:Quassins; C076339:isobrucein B; D005900:Glaucarubin