The requirements and development of neutron beams for neutron capture therapy of brain cancer.
One of the two overriding conditions for successful BNCT is that there must be a sufficient number of thermal neutrons delivered to each of the boronated cells in the tumour bed (target volume). Despite the poor experience with BNCT in the USA some 40 years ago, the continued apparent success of BNCT in Japan since 1968, lead indirectly to the re-start of clinical trials on BNCT in 1994 at both Brookhaven and MIT. Similar trials will start soon at Petten in Europe. At other centres worldwide, many neutron beam designs are being proposed with either thermal or epithermal neutrons, emanating predominantly from nuclear research reactors. It is apparent that whilst the success of BNCT depends on a suitable neutron beam, there is a diversity in available designs, as well as each proposed type of neutron source, with consequently different characteristics of the emergent neutron beam. The paper presents the historical development of neutron beams used for BNCT, addresses the requirements on the types of beams, describes some of the existing designs and other proposals elsewhere and lastly, considers the broader requirements in designing NCT facilities. The focus of the paper is on treatment of brain cancer, neutron beam requirements for other types of cancer may vary.
Moss
R L
RL
HFR Unit, JRC-IAM, European Commission, Petten, The Netherlands.
Aizawa
O
O
Beynon
D
D
Brugger
R
R
Constantine
G
G
Harling
O
O
Liu
H B
HB
Watkins
P
P
D016754:Boron Neutron Capture Therapy / Q000295:instrumentation* / Q000379:methods; D001932:Brain Neoplasms / Q000532:radiotherapy*; D004867:Equipment Design; D006801:Humans; D009502:Neutrons; D009688:Nuclear Reactors