[Hypertrophy due to left cardiac insufficiency: role of the neurohumoral system].
Left ventricular hypertrophy in patients with hypertensive heart disease is associated with impaired relaxation and myocardial interstitial fibrosis leading to enhanced filling pressure, referred to as left ventricular diastolic dysfunction. Impairment of systolic function, characterized by reduced ejection fraction occurs at a later stage. Activation of the renin-angiotensin-aldosterone system contributes to progression to heart failure by at least two mechanisms: (1) increased left ventricular loading conditions due to vasoconstriction and retention of sodium; (2) direct effects on the myocardium resulting in myocyte hypertrophy and interstitial fibrosis.
Lerch
R
R
Département de Médecine Interne, Hôpitaux Universitaires de Genève.
Montessuit
C
C
D000450:Aldosterone / Q000502:physiology; D000804:Angiotensin II / Q000502:physiology; D001127:Arginine Vasopressin / Q000502:physiology; D009320:Atrial Natriuretic Factor / Q000502:physiology; D006333:Heart Failure / Q000150:complications / Q000503:physiopathology*; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000150:complications / Q000503:physiopathology*; D018377:Neurotransmitter Agents / Q000502:physiology*; D009638:Norepinephrine / Q000502:physiology; D012083:Renin / Q000502:physiology; D013318:Stroke Volume; D013599:Systole / Q000502:physiology; D018487:Ventricular Dysfunction, Left / Q000150:complications / Q000503:physiopathology*
D018377:Neurotransmitter Agents; D000804:Angiotensin II; D001127:Arginine Vasopressin; D000450:Aldosterone; D009320:Atrial Natriuretic Factor; D012083:Renin; D009638:Norepinephrine
De l'hypertrophie à l'insuffisance cardiaque gauche: rôle du système neuro-humoral.