title: Cutaneous and neurologic disease associated with HTLV-I infection.
abstract: Human T-lymphotropic virus type I (HTLV-I) is the etiologic agent of HTLV-I associated myelopathy (HAM)/tropical spastic paresis (TSP), and adult T-cell leukemia/lymphoma (ATLL). ATLL has been associated with HTLV-I in the southeastern United States. However, to our knowledge, no case reports of HAM/TSP in association with ATLL occurring in the United States have been described. We describe a 40-year-old black woman with a 10-year history of recalcitrant psoriasiform eruption and erythrodermic flares. Medical history is additionally significant for a 2-year history of HTLV-I-associated myelopathy and lower extremity spastic paresis. Polymerase chain reaction with Southern blot analysis was used to detect HTLV-I proviral genome from frozen skin biopsy specimens and peripheral blood mononuclear cells.
authors.affiliation: Dermatology Clinic, University of Wisconsin Hospital and Clinics, Madison, USA.
authors.forename: H H
authors.initials: HH
authors.lastname: Sharata
authors.forename: J H
authors.initials: JH
authors.lastname: Colvin
authors.forename: K
authors.initials: K
authors.lastname: Fujiwara
authors.forename: B
authors.initials: B
authors.lastname: Goldman
authors.forename: K
authors.initials: K
authors.lastname: Hashimoto
mesh_terms: D000328:Adult; D005260:Female; D015368:Human T-lymphotropic virus 1 / Q000302:isolation & purification; D006801:Humans; D016130:Immunophenotyping; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000150:complications* / Q000276:immunology / Q000821:virology; D015493:Paraparesis, Tropical Spastic / Q000150:complications* / Q000276:immunology / Q000821:virology; D016133:Polymerase Chain Reaction; D012867:Skin / Q000473:pathology / Q000821:virology; D012871:Skin Diseases / Q000150:complications*