title: Mapping genes controlling hematocrit in the spontaneously hypertensive rat.
abstract: The genes that determine the baseline hematocrit level in humans and experimental animals are unknown. The spontaneously hypertensive rat (SHR), the most widely used animal model of human essential hypertension, exhibits an increased hematocrit when compared with the normotensive Brown Norway (BN-Lx) strain (0.54 +/- 0.02 vs. 0.44 +/- 0.02, p < 0.01). Distribution of hematocrit values among recombinant inbred (RI) strains derived from SHR and BN-Lx progenitors was continuous, which suggests a polygenic mode of inheritance. The narrow heritability of the hematocrit was estimated to be 0.32. The Eno2 marker on Chromosome (Chr) 4 showed the strongest association (p < 0.0001) with the observed variability of hematocrit among RI strains. The erythropoietin (Epo) gene, originally reported to be syntenic with Eno2, has been mapped to Chr 12, thus excluding it as a potential candidate gene for the increased hematocrit in the SHR. The current linkage data extend homologies between rat, mouse, and human chromosomes.
authors.affiliation: Institute of Physiology, Academy of Sciences of the Czech Republic, Vídenská 1083, 142 20 Prague 4, Czech Republic.
authors.forename: M
authors.initials: M
authors.lastname: Pravenec
authors.forename: V
authors.initials: V
authors.lastname: Zidek
authors.forename: M
authors.initials: M
authors.lastname: Zdobinska
authors.forename: V
authors.initials: V
authors.lastname: Kren
authors.forename: D
authors.initials: D
authors.lastname: Krenova
authors.forename: A
authors.initials: A
authors.lastname: Bottger
authors.forename: L F
authors.initials: LF
authors.lastname: van Zutphen
authors.forename: J
authors.initials: J
authors.lastname: Wang
authors.forename: E
authors.initials: E
authors.lastname: St Lezin
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D002874:Chromosome Mapping / Q000379:methods*; D002875:Chromosomes; D004921:Erythropoietin / Q000235:genetics*; D008040:Genetic Linkage; D005819:Genetic Markers; D006400:Hematocrit; D006801:Humans; D051379:Mice; D051381:Rats; D011918:Rats, Inbred SHR / Q000235:genetics*; D011919:Rats, Inbred Strains; D011995:Recombination, Genetic
chemical_list: D005819:Genetic Markers; D004921:Erythropoietin