Role of redchilli (Capsaicin) in the formation of colonic carcinoma.
The effect of feeding redchilli (Capsaicin) powder on the histopathological changes occurring in the colonic mucosa was studied in rats. These animals were compared with those treated with a colonic carcinogen 1,2-dimethylhydrazine (DMH). Animals fed with redchilli, dimethylhydrazine, dimethylhydrazine plus redchilli powder showed polyp and dysplasia, malignant tumour and malignant tumour with transitional area of dysplasia.
Chitra
S
S
Department of Biochemistry, Faculty of Medicine, Annamalai University, Tamil Nadu, India.
Viswanathan
P
P
Nalini
N
N
Sabitha
K
K
Menon
V P
VP
D019813:1,2-Dimethylhydrazine; D000818:Animals; D002277:Carcinoma / Q000209:etiology* / Q000473:pathology; D003108:Colonic Diseases / Q000209:etiology* / Q000473:pathology; D003110:Colonic Neoplasms / Q000209:etiology* / Q000473:pathology; D004127:Dimethylhydrazines / Q000009:adverse effects*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D017365:Spices / Q000009:adverse effects*
D004127:Dimethylhydrazines; D019813:1,2-Dimethylhydrazine