HLA antigens in microscopic polyarteritis (MP) with renal involvement.
Serological HLA-A, B, C, DR and DQ typing was performed in 23 patients with microscopic polyarteritis and renal involvement and in 405 healthy individuals, all of Greek origin. An increased frequency of HLA-A26 (26% vs. 11.3%, x2 = 4.423, p < 0.05) and HLA-A11 (26% vs. 9.6%, x2 = 6.825, P < 0.02), and a decreased frequency of HLA-DR3 (4.3% vs. 24.1%, x2 = 5.935, p < 0.025) were found. Five out of six patients, who did not respond to treatment possessed HLA-DR5. These observations suggest that HLA gene products may influence the clinical expression, as well as the outcome of this disease.
Papasteriades
C
C
Department of Immunology and Histocompatibility, Evangelismos Hospital, Athens, Greece.
Hatziyannakos
D
D
Siakotos
M
M
Pappas
H
H
Tarassi
K
K
Nikolopoulou
N
N
Michael
S
S
Kaninis
C H
CH
Vosnides
G
G
Sotsiou
F
F
Billis
A
A
D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D005921:Glomerulonephritis / Q000276:immunology* / Q000473:pathology; D006680:HLA Antigens / Q000097:blood* / Q000502:physiology; D015234:HLA-A Antigens / Q000097:blood / Q000502:physiology; D006684:HLA-DR Antigens / Q000097:blood / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010488:Polyarteritis Nodosa / Q000276:immunology* / Q000473:pathology
D006680:HLA Antigens; D015234:HLA-A Antigens; D006684:HLA-DR Antigens