Tumor suppressors: a developing role for p53?
An increasing body of evidence indicates that p53, the product of a tumour suppressor gene, has a role in development - could this developmental role have provided the primary driving force in the evolution of a protein best known as a stress-response integrator?
Hall
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PA
Department of Molecular and Cellular Pathology, University of Dundee, Dundee, DD1 9SY, UK.
Lane
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DP
D000016:Abnormalities, Radiation-Induced / Q000235:genetics; D000222:Adaptation, Physiological / Q000235:genetics; D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000818:Animals; D002648:Child; D002675:Child, Preschool; D005314:Embryonic and Fetal Development / Q000235:genetics*; D005313:Fetal Death / Q000209:etiology; D018507:Gene Expression Regulation, Developmental; D016158:Genes, p53; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D051379:Mice; D018345:Mice, Knockout; D008875:Middle Aged; D009369:Neoplasms / Q000453:epidemiology / Q000235:genetics*; D011833:Radiation Injuries, Experimental / Q000235:genetics; D013312:Stress, Physiological / Q000235:genetics / Q000503:physiopathology; D016159:Tumor Suppressor Protein p53 / Q000502:physiology*
D016159:Tumor Suppressor Protein p53