title: Role of cholesterol in the regulation of renal phosphate transport.
abstract: The kidney plays a critical role in the regulation of inorganic phosphate (Pi) homeostasis through changes in the proximal tubular apical membrane Na-dependent Pi (Na/Pi) transport activity. In response to alterations in dietary Pi intake and during the aging process, changes in renal Na/Pi transport activity are inversely correlated with apical membrane cholesterol content. Cholesterol regulates Na/Pi transport activity by fluidity-dependent and fluidity-independent mechanisms, including regulation of Na/Pi protein transcription, synthesis, and trafficking to and from the plasma membrane.
authors.affiliation: Department of Medicine, The University of Texas Southwestern Medical Center at Dallas, Texas 75216, USA.
authors.forename: H
authors.initials: H
authors.lastname: Wang
authors.forename: H
authors.initials: H
authors.lastname: Zajicek
authors.forename: V
authors.initials: V
authors.lastname: Kumar
authors.forename: P
authors.initials: P
authors.lastname: Wilson
authors.forename: M
authors.initials: M
authors.lastname: Levi
mesh_terms: D000818:Animals; D002784:Cholesterol / Q000502:physiology*; D006801:Humans; D017136:Ion Transport; D007668:Kidney / Q000378:metabolism*; D010710:Phosphates / Q000378:metabolism*; D051381:Rats
chemical_list: D010710:Phosphates; D002784:Cholesterol