title: Analysis of ribosomal and alphoid repetitive DNA by fiber-FISH.
abstract: We have used fluorescence in situ hybridization to extended DNA fibers (fiber-FISH) to analyse the alpha-satellite and rDNA arrays on a human chromosome 22. The rDNA could be seen as a string of signals spanning about 430 kb. The bulk of the alphoid DNA was found in a single large array of about 2.6 Mb.
authors.affiliation: Department of Biochemistry and Molecular Genetics, Imperial College School of Medicine at St. Mary's London, UK.
authors.forename: C
authors.initials: C
authors.lastname: Shiels
authors.forename: C
authors.initials: C
authors.lastname: Coutelle
authors.forename: C
authors.initials: C
authors.lastname: Huxley
mesh_terms: D002460:Cell Line; D002892:Chromosomes, Human, Pair 22; D004275:DNA, Ribosomal; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D012091:Repetitive Sequences, Nucleic Acid; D012270:Ribosomes
chemical_list: D004275:DNA, Ribosomal