title: Early experience with single lung transplantation for emphysema with simultaneous volume reduction of the contralateral lung.
abstract: OBJECTIVE
  Single lung transplantation (SLT) for emphysema has given satisfactory long term results in most patients. The mediastinal shift caused by the native emphysematous lung may require further surgical intervention in selected cases.
  
  
  METHODS
  We report a technique of simultaneous SLT and volume reduction of the contralateral lung in 4 patients with end stage respiratory failure secondary to emphysema. There were two right and two left SLT, performed in two male and two female patients. Their mean age was 52.2 (S.D. 4) years (range between 41 and 57 years) and the ischaemia time averaged 255.6 (S.D. 16) min (range between 225 and 255 min). The volume of the contralateral lung was reduced using staples. The stapled lines were buttressed by the donors pericardium.
  
  
  RESULTS
  Their were no operative related complications apart from air leak which settled spontaneously within 5 days postoperatively. Teh pre-operative FEVI showed a mean value of 0.57 (S.D. 0.1) L (17.2% (S.D. 2) of the predicted) which improved to 1.79 (S.D. 0.4) L (58.2% (S.D. 8) of the predicted) at last follow up (P < 0.005). Radiological examinations at 1 year showed central mediastinum with satisfactory respiratory function.
  
  
  CONCLUSIONS
  We conclude that this technique can be performed for patients with emphysema without increase in the operative morbidity and with good early respiratory function. Further follow up is required to assess the long term results of this procedure.
authors.affiliation: Transplant Unit, Harefield Hospital, Middlesex, UK.
authors.forename: A
authors.initials: A
authors.lastname: Khaghani
authors.forename: K M
authors.initials: KM
authors.lastname: al-Kattan
authors.forename: S
authors.initials: S
authors.lastname: Tadjkarimi
authors.forename: N
authors.initials: N
authors.lastname: Banner
authors.forename: M
authors.initials: M
authors.lastname: Yacoub
mesh_terms: D000328:Adult; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D005541:Forced Expiratory Volume / Q000502:physiology; D006801:Humans; D016040:Lung Transplantation / Q000502:physiology; D008297:Male; D008875:Middle Aged; D011013:Pneumonectomy; D011183:Postoperative Complications / Q000503:physiopathology; D011656:Pulmonary Emphysema / Q000601:surgery*; D016896:Treatment Outcome