title: [Influence on extratumoral organ activities of tumor-affinity samarium-153 preparations].
abstract: OBJECTIVE
  Possibilities to exercise an influence on the biodistribution of a tumor-affine 153Sm-preparation, samarium-153-nitrilotriacetate (NTA), were tested.
  
  
  METHODS
  Animals experiments on tumor-bearing mice after additional application of EDTMP (ethylenediamine tetramethylene phosphonate) for the reduction of extratumorale liver-radioactivity and yttrium chloride for the reduction of unwanted underground radioactivity in bone were carried out. Furthermore, the combination of both measurements was tested.
  
  
  RESULTS
  The biodistribution of 153Sm-NTA showed a rather low tumor-radioactivity of app. 0.72%/g. The additional EDTMP-application caused a dose-dependent decrease of the underground-radioactivity in liver especially if given 2 h in advance or simultaneously. The additional application of the stable yttrium salt reduced the bone radioactivity on simultaneous increase of liver- and spleen-radioactivity and practically unchanged tumor-radioactivity. The combined use of EDTMP together with the bone-affine metal salt led to a reduction of liver radioactivity on simultaneous reduction of bone radioactivity.
  
  
  CONCLUSIONS
  The background radioactivity can be reduced on unchanged tumor-radioactivity by combined Na-EDTMP/YCl3-application. The present results do not allow a therapeutic exploitation because of the low tumor accumulation.
authors.affiliation: Klinik und Poliklinik für Nuklearmedizin, Universität zu Köln, Deutschland.
authors.forename: K
authors.initials: K
authors.lastname: Schomäcker
authors.forename: H
authors.initials: H
authors.lastname: Hebrank
authors.forename: K
authors.initials: K
authors.lastname: Scheidhauer
authors.forename: A
authors.initials: A
authors.lastname: Scharl
authors.forename: J C
authors.initials: JC
authors.lastname: Saccavini
authors.forename: S K
authors.initials: SK
authors.lastname: Shukla
authors.forename: W G
authors.initials: WG
authors.lastname: Franke
authors.forename: H
authors.initials: H
authors.lastname: Schicha
mesh_terms: D000818:Animals; D002277:Carcinoma / Q000000981:diagnostic imaging*; D002614:Chelating Agents / Q000494:pharmacology; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA; D009571:Nitrilotriacetic Acid / Q000493:pharmacokinetics / Q000494:pharmacology*; D009943:Organophosphorus Compounds / Q000494:pharmacology; D011868:Radioisotopes; D011877:Radionuclide Imaging; D012493:Samarium / Q000493:pharmacokinetics / Q000494:pharmacology*; D014018:Tissue Distribution; D015019:Yttrium / Q000494:pharmacology
chemical_list: D002614:Chelating Agents; D009943:Organophosphorus Compounds; D011868:Radioisotopes; C064782:yttrium chloride; C018940:(ethylenedinitrilo)-tetramethylenephosphonic acid; D012493:Samarium; D015019:Yttrium; D009571:Nitrilotriacetic Acid
vernacular_title: Beeinflussung extratumoraler Organaktivitäten von tumoraffinen Samarium-153-Zubereitungen.