Effect of endurance training on ammonia and amino acid metabolism in humans.
Few studies examine ammonia and amino acid metabolism in response to endurance training. Trained humans generally experience less increase in plasma ammonia during either prolonged or intense exercise. This is probably a reflection of reduced ammonia production and release from the active muscle; it could be a reflection of decreased AMP deaminase activity, decreased glutamate dehydrogenase activity, and/or increased alanine and glutamine formation. Little is known regarding the associated enzyme systems in humans, but in experiments with animal models, aerobic training decreases AMP deaminase and increases the enzymes of amino acid transamination and oxidation.
Graham
T E
TE
Copenhagen Muscle Research Centre, August Krogh Institute, University of Copenhagen, Denmark.
Turcotte
L P
LP
Kiens
B
B
Richter
E A
EA
D000659:AMP Deaminase / Q000378:metabolism; D000409:Alanine / Q000378:metabolism; D000596:Amino Acids / Q000378:metabolism*; D000597:Amino Acids, Branched-Chain / Q000378:metabolism; D000641:Ammonia / Q000378:metabolism*; D015444:Exercise / Q000502:physiology*; D005969:Glutamate Dehydrogenase / Q000378:metabolism; D005973:Glutamine / Q000378:metabolism; D006801:Humans; D009124:Muscle Proteins / Q000378:metabolism; D018482:Muscle, Skeletal / Q000378:metabolism*; D010084:Oxidation-Reduction; D010807:Physical Endurance / Q000502:physiology*
D000596:Amino Acids; D000597:Amino Acids, Branched-Chain; D009124:Muscle Proteins; D005973:Glutamine; D000641:Ammonia; D005969:Glutamate Dehydrogenase; D000659:AMP Deaminase; D000409:Alanine