[The repair of the membrane lipid bilayer in oxidative stress: phosphatidylethanolamine reacylation in synaptosome, photoreceptor and erythrocyte membranes].
The participation of unsaturated (linoleic and arachidonic) and saturated (palmitic) fatty acids in reacylation of phosphatidylethanolamine (PE) in synaptosomes, photoreceptor membranes and erythrocytes at oxidative stress was studied. Induction of lipid peroxidation (LPO) was found to result in a significant decrease in the content of PE polyenoic fatty acids due to their oxidative destruction. It might be related to both an activation of phospholipase A2 and a decrease in PE reacylation rate. On contrary, under the same conditions an increase in incorporation of palmitic acid into PE was observed. The results of this study suggest that phospholipid deacylation-reacylation reactions comprise an important mechanism of both protection and adaptation of organisms to oxidative stress.
Tiurin
V A
VA
Arduini
A
A
Tiurina
Iu Iu
IuIu
Sokolova
T V
TV
Furaev
V V
VV
Rychkova
M P
MP
Arrigoni-Martelli
E
E
D000215:Acylation; D000818:Animals; D001921:Brain / Q000378:metabolism; D002417:Cattle; D004910:Erythrocyte Membrane / Q000378:metabolism*; D005227:Fatty Acids / Q000378:metabolism; D006801:Humans; D008051:Lipid Bilayers / Q000378:metabolism*; D015227:Lipid Peroxidation; D008297:Male; D008563:Membrane Lipids / Q000378:metabolism*; D018384:Oxidative Stress / Q000502:physiology*; D010714:Phosphatidylethanolamines / Q000378:metabolism*; D010786:Photoreceptor Cells / Q000378:metabolism*; D051381:Rats; D013574:Synaptosomes / Q000378:metabolism*
D005227:Fatty Acids; D008051:Lipid Bilayers; D008563:Membrane Lipids; D010714:Phosphatidylethanolamines
Reparatsiia lipidnogo biosloia membran pri okislitel'nom stresse: reatsilirovanie fosfatidilétanolamina v membranakh sinaptosom, fotoretseptorov i éritrotsitov.