[A comparative study of the membrane-protector efficacy of anaprilin and korinfar in hypertension patients].
Beta-blocker anapriline and calcium antagonist corinfar are highly effective hypotensive agents. Drop in diastolic arterial pressure with anapriline therapy amounted to 15.9 and 15.6%, with corinfar therapy-to 15.0 and 15.6% in hypertensive disease stage I and II respectively. Hypotensive action of corinfar might result from correction of impaired cation-transport function of cellular membranes, electrolyte homeostasis of cells, phospholipid composition of membranes. No dynamics has been revealed of the membrane tests under study during administration of anapriline therapy treatments.
Gapon
L I
LI
Kremneva
L V
LV
Abaturova
O V
OV
D000293:Adolescent; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology / Q000627:therapeutic use*; D000328:Adult; D000959:Antihypertensive Agents / Q000494:pharmacology / Q000627:therapeutic use*; D002121:Calcium Channel Blockers / Q000494:pharmacology / Q000627:therapeutic use*; D004341:Drug Evaluation; D004573:Electrolytes / Q000097:blood; D004910:Erythrocyte Membrane / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000188:drug therapy*; D008563:Membrane Lipids / Q000097:blood; D008875:Middle Aged; D009543:Nifedipine / Q000494:pharmacology / Q000627:therapeutic use*; D010743:Phospholipids / Q000097:blood; D011433:Propranolol / Q000494:pharmacology / Q000627:therapeutic use*
D000319:Adrenergic beta-Antagonists; D000959:Antihypertensive Agents; D002121:Calcium Channel Blockers; D004573:Electrolytes; D008563:Membrane Lipids; D010743:Phospholipids; D011433:Propranolol; D009543:Nifedipine
Sravnitel'noe issledovanie membranoprotektornoĭ éffektivnosti anaprilina i korinfara u bol'nykh gipertonicheskoĭ bolezn'iu.