Widespread dilatation of perivascular spaces: a leukoencephalopathy causing dementia.
A 68-year-old demented woman had widespread dilatation of perivascular spaces in the cerebral white matter for at least 12 years. There were no micro-infarcts, but some vessel walls in the white matter were thickened by a loose fibrosis. Our case does not correspond to Binswanger's disease or any other known vascular leukoencephalopathy. The longstanding evolution points to a nonfamilial leukoencephalopathy of probable vascular origin.
Vital
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C
Neuropathology Laboratory, Pellegrin Hospital, Bordeaux, France.
Julien
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J
D000368:Aged; D001921:Brain / Q000473:pathology; D001927:Brain Diseases / Q000150:complications* / Q000175:diagnosis; D003704:Dementia / Q000209:etiology*; D017809:Fatal Outcome; D005260:Female; D005355:Fibrosis; D006801:Humans; D008279:Magnetic Resonance Imaging; D014057:Tomography, X-Ray Computed