[The effect of fructose-1,6-diphosphate, cytochrome c and their combination on the size of the necrotic area in transient myocardial ischemia].
The effect of fructose-1, 6-diphosphate (200 mg/kg), cytochrome C (20 mg/kg) and their combinations on the size of the zone of necrosis 4 and 72 h after 15-min transitory myocardial ischemia was studied. Combination of the compounds under study inhibited considerably the development of post-occlusion and reperfusion arrhythmias and reduced the size of necrosis 4 h after their administration as prophylactic and arresting measures (to 23.8 +/- 2.9 and 29.3 +/- 3.6% of the ischemic zone, respectively, in 42.8 +/- 3.8% in the control). A combined course of cytochrome C and fructose diphosphate also limited the size of the necrotic zone 72 h after transitory ischemia. Separate single administration of fructose diphosphate and cytochrome C caused no essential changes in the size of myocardial necrosis recorded 72 h after transitory myocardial ischemia.
Imatdieva
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Gatsura
V V
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D000818:Animals; D002317:Cardiovascular Agents / Q000627:therapeutic use*; D003574:Cytochrome c Group / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D005635:Fructosediphosphates / Q000627:therapeutic use*; D006321:Heart / Q000187:drug effects*; D008297:Male; D017202:Myocardial Ischemia / Q000188:drug therapy* / Q000473:pathology; D009206:Myocardium / Q000473:pathology; D009336:Necrosis; D051381:Rats; D013997:Time Factors
D002317:Cardiovascular Agents; D003574:Cytochrome c Group; D005635:Fructosediphosphates; C029063:fructose-1,6-diphosphate
Vliianie fruktozo-1,6-difosfata, tsitokhroma c i ikh kombinatsii na razmery zony nekroza pri tranzitornoĭ ishemii miokarda.