Are S-layer glycoproteins and lipopolysaccharides related?
Several glycan structures of S-layer glycoproteins of gram-positive eubacteria were compared with the principal structural organization of O-antigens of lipopolysaccharides of gram-negative eubacteria. Further, activated intermediates of the biosynthetic pathway of S-layer glycans were compared with activated intermediates of the route of assembly of lipopolysaccharide O-antigens. As a result, at least structural similarities between both types of molecules have been clearly observed. More detailed studies of the assembly of S-layer glycans are required to unambiguously demonstrate the extent to which the biosynthetic pathways of both molecules are related.
Schäffer
C
C
Zentrum für Ultrastrukturforschung, Universität für Bodenkultur, Wien, Austria.
Wugeditsch
T
T
Neuninger
C
C
Messner
P
P
D001407:Bacillus / Q000378:metabolism; D001419:Bacteria / Q000378:metabolism* / Q000648:ultrastructure; D001421:Bacteria, Anaerobic / Q000378:metabolism; D001426:Bacterial Proteins / Q000096:biosynthesis* / Q000737:chemistry / Q000302:isolation & purification; D050260:Carbohydrate Metabolism; D002240:Carbohydrate Sequence; D002241:Carbohydrates / Q000737:chemistry; D003013:Clostridium / Q000378:metabolism; D006020:Glycopeptides / Q000096:biosynthesis / Q000737:chemistry / Q000302:isolation & purification; D008070:Lipopolysaccharides / Q000096:biosynthesis* / Q000737:chemistry; D008562:Membrane Glycoproteins / Q000096:biosynthesis* / Q000737:chemistry / Q000302:isolation & purification; D008854:Microscopy, Electron; D008969:Molecular Sequence Data; D008970:Molecular Weight; D009844:Oligosaccharides / Q000096:biosynthesis
D001426:Bacterial Proteins; D002241:Carbohydrates; D006020:Glycopeptides; D008070:Lipopolysaccharides; D008562:Membrane Glycoproteins; D009844:Oligosaccharides; C055764:S-layer proteins