Flow cytometry tear analysis in patients with chronic allergic conjunctivitis.
Tears from patients with chronic allergic conjunctivitis were analyzed with flow cytometry to determine the function of the T lymphocyte-related immunological reactions in the disease pathogenesis. Twenty-eight patients and 22 normal volunteers were studied; tears were obtained with capillary tubes. T helper/T suppressor ratios and the percentages of HLA DR+, CD23+, and CD3+ cells were significantly higher in patients than in controls. This study provides support for the hypothesis that chronic allergic conjunctivitis results from T lymphocyte-related immunological reactions.
Avunduk
A M
AM
Ophthalmology Department, School of Medicine, Black Sea Technical University, Trabzon, Turkey.
Avunduk
M C
MC
Dayioglu
Y S
YS
Centinkaya
K
K
D000293:Adolescent; D000328:Adult; D002908:Chronic Disease; D003233:Conjunctivitis, Allergic / Q000276:immunology*; D005260:Female; D005434:Flow Cytometry; D006684:HLA-DR Antigens / Q000032:analysis; D006801:Humans; D008297:Male; D017455:Receptors, IgE / Q000032:analysis; D013601:T-Lymphocytes / Q000473:pathology; D013666:Tears / Q000737:chemistry* / Q000166:cytology
D006684:HLA-DR Antigens; D017455:Receptors, IgE