Hysterectomy, oophorectomy, and heart disease risk factors in older women.
OBJECTIVE
This study examined the relation of hysterectomy and oophorectomy to heart disease risk factors.


METHODS
Data were collected and analyzed for 1150 women aged 50 through 89.


RESULTS
Of these women, 21.8% reported hysterectomy with bilateral oophorectomy; 22.1%, hysterectomy with ovarian conservation. Compared with women without hysterectomy, oophorectomized women, especially those 20 or more years postmenopause, had increased lipids, lipoproteins, glucose, and insulin; blood pressures were increased among current estrogen users. Women with hysterectomies with ovarian conservation had similar or more favorable risk factors than nonhysterectomized women.


CONCLUSIONS
Bilateral oophorectomy, but not hysterectomy, may have long-term negative consequences for heart disease risk factors not totally ameliorated by estrogen use.
Kritz-Silverstein
D
D
Department of Family and Preventive Medicine, University of California-San Diego 92093-0607, USA.
Barrett-Connor
E
E
Wingard
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DL
D000368:Aged; D000369:Aged, 80 and over; D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure; D015914:Estrogen Replacement Therapy; D005260:Female; D006331:Heart Diseases / Q000209:etiology*; D006801:Humans; D007044:Hysterectomy / Q000009:adverse effects*; D007328:Insulin / Q000097:blood; D008055:Lipids / Q000097:blood; D008074:Lipoproteins / Q000097:blood; D008875:Middle Aged; D010052:Ovariectomy / Q000009:adverse effects*; D017698:Postmenopause; D012307:Risk Factors
D001786:Blood Glucose; D007328:Insulin; D008055:Lipids; D008074:Lipoproteins