Budesonide in the management of patients with Crohn's disease.
Modern medical therapy is increasingly based on evidence. The evidence presented here is that budesonide (Entocort, Astra Pharma) 9 mg/day is superior to placebo and equivalent to systemically active glucocorticosteroids in achieving disease remission in patients with active Crohn's disease, and in prolonging the recurrence time of symptomatic disease. Budesonide causes less disturbance to adrenal function than prednisone or prednisolone and may cause fewer steroid-associated symptoms. Thus, budesonide is the safer, more effective steroid of choice to treat patients with Crohn's disease.
Thomson
A B
AB
Division of Gastroenterology, University of Alberta, Edmonton. alan.thomson@ualberta.ca
Sadowski
D
D
Jenkins
R
R
Wild
G
G
D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D019819:Budesonide; D003424:Crohn Disease / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D011239:Prednisolone / Q000627:therapeutic use; D011282:Pregnenediones / Q000627:therapeutic use*; D011379:Prognosis; D016032:Randomized Controlled Trials as Topic; D012074:Remission Induction
D000893:Anti-Inflammatory Agents; D011282:Pregnenediones; D019819:Budesonide; D011239:Prednisolone