Parvovirus B19 associated neutropenia. Treatment with Rh G-CSF.
In a 39-year-old patient under follow-up for metastatic adenocarcinoma of the colon, a post-operative fever and a profound neutropenia occurred during hospitalization. A diagnosis of primary infection with parvovirus B-19 was made in view of the association of reticulocytopenia, together with anti-B19 IgM antibodies and positive serum results for viral DNA. The granulocytic lineage appeared to be normal on bone-marrow smears, and anti PMN autoantibodies were not found. Rh G-CSF therapy resulted in a sharp increase in the PMN count. Although the pathophysiology of B19-associated neutropenia remains unclear, Rh G-CSF seems to be effective in this disorder.
Gautier
E
E
Service de Microbiologie Médicale, Institut Gustave Roussy, Villejuif, France.
Bourhis
J H
JH
Bayle
C
C
Cartron
J
J
Pico
J L
JL
Tchernia
G
G
D000230:Adenocarcinoma / Q000150:complications / Q000556:secondary / Q000601:surgery; D000328:Adult; D000583:Amikacin / Q000008:administration & dosage / Q000627:therapeutic use; D003110:Colonic Neoplasms / Q000150:complications / Q000601:surgery; D004279:DNA, Viral / Q000097:blood; D005260:Female; D000069585:Filgrastim; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use*; D006801:Humans; D007275:Injections, Intravenous; D008113:Liver Neoplasms / Q000150:complications / Q000556:secondary; D009503:Neutropenia / Q000188:drug therapy* / Q000209:etiology / Q000821:virology*; D010322:Parvoviridae Infections / Q000188:drug therapy* / Q000209:etiology; D016732:Parvovirus B19, Human / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*; D015366:Pefloxacin / Q000008:administration & dosage / Q000627:therapeutic use; D010397:Penicillanic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000627:therapeutic use; D010878:Piperacillin / Q000008:administration & dosage / Q000627:therapeutic use; D011994:Recombinant Proteins; D000078142:Tazobactam
D004279:DNA, Viral; D011994:Recombinant Proteins; D016179:Granulocyte Colony-Stimulating Factor; D015366:Pefloxacin; D000583:Amikacin; D010397:Penicillanic Acid; D000069585:Filgrastim; D000078142:Tazobactam; D010878:Piperacillin