title: Evidence for a dopaminergic involvement in the natriuretic action of centrally administered renin.
abstract: Intracerebroventricular (IVT) administration of renin (R) to conscious male hydrated rats induces an increase in sodium excretion. The involvement of brain dopaminergic neurons in the renal action of IVT-R was investigated. Renin-induced natriuretic action was prevented by domperidone and by inhibition of tyrosine hydroxylase activity with alpha-methyl-p-tyrosine treatment. In addition, this effect was absent following selective central dopaminergic denervation with 6-hydroxydopamine (IVT) in combination with desmethylimipramine (IP). Our results suggest that renin acts centrally, at least in part, via an interaction with endogenous dopamine systems.
authors.affiliation: Department of Biological Sciences, Universidad Central de Venezuela, Caracas, Venezuela.
authors.forename: A
authors.initials: A
authors.lastname: Israel
authors.forename: M
authors.initials: M
authors.lastname: Cierco
authors.forename: M
authors.initials: M
authors.lastname: Salazar
authors.forename: Y
authors.initials: Y
authors.lastname: Barbella
mesh_terms: D000818:Animals; D001921:Brain / Q000166:cytology / Q000187:drug effects*; D004294:Domperidone / Q000494:pharmacology; D004298:Dopamine / Q000502:physiology*; D018492:Dopamine Antagonists / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical; D004791:Enzyme Inhibitors / Q000494:pharmacology; D007276:Injections, Intraventricular; D008297:Male; D008781:Methyltyrosines / Q000494:pharmacology; D009318:Natriuresis / Q000187:drug effects*; D009474:Neurons / Q000187:drug effects*; D009498:Neurotoxins; D051381:Rats; D017207:Rats, Sprague-Dawley; D012083:Renin / Q000494:pharmacology*; D014446:Tyrosine 3-Monooxygenase / Q000037:antagonists & inhibitors; D019805:alpha-Methyltyrosine
chemical_list: D018492:Dopamine Antagonists; D004791:Enzyme Inhibitors; D008781:Methyltyrosines; D009498:Neurotoxins; D004294:Domperidone; D019805:alpha-Methyltyrosine; D014446:Tyrosine 3-Monooxygenase; D012083:Renin; D004298:Dopamine