Endosomes, receptor tyrosine kinase internalization and signal transduction.
Upon the binding of insulin or epidermal growth factor to their cognate receptors on the liver parenchymal plasmalemma, signal transduction and receptor internalization are near co-incident. Indeed, the rapidity and extent of ligand mediated receptor internalization into endosomes in liver as well as other organs predicts that signal transduction is regulated at this intracellular locus. Although internalization has been thought as a mechanism to attenuate ligand mediated signal transduction responses, detailed studies of internalized receptors in isolated liver endosomes suggest an alternative scenario whereby selective signal transduction pathways can be accessed at this locus.
Bergeron
J J
JJ
Department of Anatomy and Cell Biology, McGill University, Montreal, Canada.
Di Guglielmo
G M
GM
Baass
P C
PC
Authier
F
F
Posner
B I
BI
D000818:Animals; D011992:Endosomes / Q000378:metabolism*; D004815:Epidermal Growth Factor / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000378:metabolism; D007424:Intracellular Fluid / Q000378:metabolism; D008024:Ligands; D008099:Liver / Q000378:metabolism; D008954:Models, Biological; D020794:Receptor Protein-Tyrosine Kinases / Q000378:metabolism*; D011972:Receptor, Insulin / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*
D007328:Insulin; D008024:Ligands; D004815:Epidermal Growth Factor; D020794:Receptor Protein-Tyrosine Kinases; D011972:Receptor, Insulin