HIV integrase: a target for AIDS therapeutics.
HIV integrase catalyses the incorporation of virally derived DNA into the human genome. This unique step in the virus life cycle provides a variety of points for intervention and hence is an attractive target for the development of new therapeutics for the treatment of AIDS. In this review we summarize current knowledge of the function of this enzyme and discuss some of the obstacles to the development of appropriate drugs.
Thomas
M
M
Department of Biochemistry, University of Bristol, UK.
Brady
L
L
D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy* / Q000821:virology; D001709:Biotechnology; D006678:HIV / Q000201:enzymology; D019427:HIV Integrase / Q000737:chemistry / Q000378:metabolism*; D019428:HIV Integrase Inhibitors / Q000627:therapeutic use*; D006801:Humans; D008958:Models, Molecular; D015394:Molecular Structure; D011487:Protein Conformation; D016662:Virus Integration
D019428:HIV Integrase Inhibitors; D019427:HIV Integrase