title: Diffusion-weighted imaging discriminates between cytotoxic and vasogenic edema in a patient with eclampsia.
abstract: BACKGROUND
  The pathophysiology of eclampsia remains unclear. While the majority of patients develop reversible T2 hyperintense signal abnormalities on MR scans and reversible neurological deficits, some patients do develop infarctions (permanent T2 hyperintense abnormalities) and permanent neurological impairment. Routine MRI cannot prospectively differentiate between these two patient groups. Echo-planar diffusion-weighted imaging, however, is a new technique that clearly differentiates between cytotoxic and vasogenic edema.
  
  
  METHODS
  A 30-year-old woman developed symptoms consistent with eclampsia 24 hours after delivering premature twins. An MRI demonstrated extensive, diffuse T2 hyperintense signal abnormalities involving subcortical white matter and adjacent gray matter with a posterior predominance, consistent with either infarction or hypertensive ischemic encephalopathy. Diffusion-weighted images demonstrated increased diffusion, consistent with vasogenic edema and hypertensive ischemic encephalopathy.
  
  
  CONCLUSIONS
  Unlike routine MRI, diffusion-weighted imaging reliably differentiates between vasogenic edema and cytotoxic edema. Consequently, in eclamptic patients diffusion-weighted imaging can afford clear differentiation between hypertensive ischemic encephalopathy and infarction, two very different entities with very different treatment protocols. Diffusion-weighted imaging should be performed in all eclamptic patients and should greatly affect their management.
authors.affiliation: Department of Radiology, Massachusetts General Hospital, Boston 02114, USA.
authors.forename: P W
authors.initials: PW
authors.lastname: Schaefer
authors.forename: F S
authors.initials: FS
authors.lastname: Buonanno
authors.forename: R G
authors.initials: RG
authors.lastname: Gonzalez
authors.forename: L H
authors.initials: LH
authors.lastname: Schwamm
mesh_terms: D000328:Adult; D001929:Brain Edema / Q000175:diagnosis* / Q000209:etiology; D002544:Cerebral Infarction / Q000150:complications / Q000175:diagnosis*; D003937:Diagnosis, Differential; D004058:Diffusion; D004461:Eclampsia / Q000150:complications* / Q000378:metabolism; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications; D008279:Magnetic Resonance Imaging / Q000379:methods*; D011247:Pregnancy; D014652:Vascular Diseases / Q000150:complications / Q000175:diagnosis*; D014664:Vasodilation