title: Macrophage migration inhibitory factor is involved in the pathogenesis of collagen type II-induced arthritis in mice.
abstract: To determine the importance of macrophage migration inhibitory factor (MIF) in the development of arthritis we used an experimental model for rheumatoid arthritis, collagen type II (CII)-induced arthritis in mice. Treatment with neutralizing anti-MIF Abs before immunization of (B10.Q x DBA/1)F1 with CII led to delayed onset and lowered frequency of arthritis. This was associated with lower levels of IgG2a to CII in MIF-depleted mice. The proliferative response to CII was stronger in the anti-MIF-treated mice, whereas no significant effects were seen on Ag-induced IFN-gamma production in response to CII or on the total serum Ab levels in response to CII. These results provide the first experimental evidence of a role for MIF in the pathogenesis of autoimmune disease.
authors.affiliation: Department of Cell and Molecular Biology, Lund University, Sweden.
authors.forename: A
authors.initials: A
authors.lastname: Mikulowska
authors.forename: C N
authors.initials: CN
authors.lastname: Metz
authors.forename: R
authors.initials: R
authors.lastname: Bucala
authors.forename: R
authors.initials: R
authors.lastname: Holmdahl
mesh_terms: D000818:Animals; D001168:Arthritis / Q000139:chemically induced / Q000276:immunology* / Q000473:pathology; D003094:Collagen; D008263:Macrophage Migration-Inhibitory Factors / Q000276:immunology*; D051379:Mice
chemical_list: D008263:Macrophage Migration-Inhibitory Factors; D003094:Collagen