[Nerve tissue-specific proteins in the assessment of the permeability of the hemato-encephalic barrier in comatose states in children].
The role of functional state of hematoencephalic barrier (HEB) was estimated in terms of development of pathological process in coma. The quantitative determination of neurospecific protein (NSP), exactly of alpha 1 and of alpha 2 cerebral globulins (produced by astrocytes and oligodendroglial cells) was used for estimation of HEB state. The clinical examination of 138 children in comatose state caused by different factor (meningitis, encephalitis, cerebrocranial trauma, infectious toxicosis) was performed. Enzyme immuno-assay of alpha 1 and of alpha 2 cerebral globulins allowed to control HEB's functional state objectively in "brain-blood" direction: in cases of alteration of HEB's function the autoantibodies to NSP may penetrate into cerebral tissue and cause nonspecific reaction in form of edema or inflammation. The membrane stabilizing effect of Dexamethazone was established.
Badalian
L O
LO
Chekhonin
V P
VP
Bembeeva
R Ts
RTs
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000510:Alpha-Globulins / Q000032:analysis / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D001327:Autoimmune Diseases / Q000209:etiology / Q000378:metabolism*; D015415:Biomarkers / Q000032:analysis; D001812:Blood-Brain Barrier / Q000187:drug effects; D002463:Cell Membrane Permeability / Q000187:drug effects; D002648:Child; D002675:Child, Preschool; D003128:Coma / Q000209:etiology / Q000378:metabolism*; D003907:Dexamethasone / Q000494:pharmacology; D005938:Glucocorticoids / Q000494:pharmacology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D009419:Nerve Tissue Proteins / Q000032:analysis / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D013997:Time Factors
D000510:Alpha-Globulins; D015415:Biomarkers; D005938:Glucocorticoids; D009419:Nerve Tissue Proteins; D003907:Dexamethasone
Spetsificheskie belki nervnoĭ tkani v otsenke pronitsaemosti gematoéntsefalicheskogo bar'era pri komatoznykh sostoianiiakh u deteĭ.