The influence of ifosfamide scheduling on acute nephrotoxicity in children.
Nephrotoxicity is a significant problem in children after treatment with ifosfamide. Acute changes in renal function were compared in 16 children receiving 9 g m(-2) of ifosfamide as a 72-h continuous infusion on one occasion and, on another course, divided into three 1-h infusions on consecutive days. Subclinical acute nephrotoxicity was demonstrated with both schedules, but there were no significant differences in severity.
English
M W
MW
Sir James Spence Institute of Child Health, The Royal Victoria Infirmary, Newcastle upon Tyne, UK.
Skinner
R
R
Pearson
A D
AD
Price
L
L
Wyllie
R
R
Craft
A W
AW
D000293:Adolescent; D018906:Antineoplastic Agents, Alkylating / Q000008:administration & dosage / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D003404:Creatinine / Q000097:blood; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007069:Ifosfamide / Q000008:administration & dosage / Q000627:therapeutic use*; D007223:Infant; D007262:Infusions, Intravenous; D007668:Kidney / Q000187:drug effects* / Q000473:pathology / Q000503:physiopathology; D007677:Kidney Function Tests; D008297:Male; D009369:Neoplasms / Q000188:drug therapy; D016482:Urinalysis
D018906:Antineoplastic Agents, Alkylating; D003404:Creatinine; D007069:Ifosfamide