Estrogen-excitable forebrain projections to the ventral premammillary nucleus of the female rat.
Retrograde labels by Nuclear Yellow from the female rat ventral premammillary nucleus (PMv) were most numerous in the lateral septum (LS) and the preoptic area (POA) and spread laterally into the substantia innominata. Other labels were in the diagonal band nucleus, the substantia innominata and the bed nucleus of the stria terminalis. Constant-current, single-pulse electrical stimulation of the PMv in urethane-anesthetized ovariectomized rats elicited antidromic action potentials in the cingulate cortex, in addition to the structures that contained labeled neurons. In the LS or cingulate cortex, but not in the POA, estrogen decreased antidromic activation thresholds and shortened refractory periods. The PMv is a way station that relays estrogen-excitable septal, but not preoptic, effects. The PMv also contains fibers of passage that originate in estrogen-excitable cingulate neurons.
Nakano
K
K
Institute of Medical Technology, Hirosaki University School of Medicine and Allied Sciences, Japan.
Suga
S
S
Kondo
Y
Y
Sato
T
T
Sakuma
Y
Y
D000818:Animals; D001562:Benzimidazoles; D004302:Dorsomedial Hypothalamic Nucleus / Q000187:drug effects*; D004558:Electric Stimulation; D004967:Estrogens / Q000494:pharmacology*; D005071:Evoked Potentials / Q000187:drug effects; D005260:Female; D005456:Fluorescent Dyes; D009434:Neural Pathways / Q000187:drug effects; D010053:Ovary / Q000502:physiology; D011301:Preoptic Area / Q000187:drug effects; D016548:Prosencephalon / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D013377:Substantia Innominata / Q000187:drug effects; D000096926:Benzenesulfonamides
D001562:Benzimidazoles; D004967:Estrogens; D005456:Fluorescent Dyes; C036574:nuclear yellow; D000096926:Benzenesulfonamides