[The effect of adrenoblockers on the ultrastructural changes in the epithelium and neural elements of the small intestine of suckling rabbits with experimental cholera].
Infant rabbits (10-12-day old) were infected with El Tor 5879 culture via stomach. During the period of cholera vibrio adhesion (within 4 hr) and twice on the following day the animals were injected intraperitoneally with alpha- and beta-adrenoblockers pyrroxan and obsidan. It was established that mono- or combined therapy with adrenergic blocking agents prevents the vibrio adhesion, cholera vibrios were detected mainly in the small intestine lumen. In addition, adrenoblockers arrest adenylate cyclase activation realized through cAMP formation and subsequent diarrhea development.
Lomov
Iu M
IuM
Kharlanova
N G
NG
Bardakhch'ian
E A
EA
D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology / Q000627:therapeutic use*; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D000833:Animals, Suckling; D002771:Cholera / Q000188:drug therapy* / Q000473:pathology; D004146:Dioxanes / Q000494:pharmacology / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D004848:Epithelium / Q000187:drug effects / Q000648:ultrastructure; D007583:Jejunum / Q000187:drug effects* / Q000294:innervation / Q000648:ultrastructure; D008854:Microscopy, Electron; D009474:Neurons / Q000187:drug effects* / Q000648:ultrastructure; D011433:Propranolol / Q000494:pharmacology / Q000627:therapeutic use*; D011817:Rabbits; D013997:Time Factors
D000317:Adrenergic alpha-Antagonists; D000319:Adrenergic beta-Antagonists; D004146:Dioxanes; D011433:Propranolol; C009143:proroxan
Vliianie adrenoblokatorov na ul'trastrukturnye izmeneniia épiteliia i nervnykh élementov tonkoĭ kishki krolikov-sosunkov pri éksperimental'noĭ kholere.