title: The impact of HLA-DRB1*0405 on disease severity in Korean patients with seropositive rheumatoid arthritis.
abstract: Many reports have described HLA-DRB1 genes as having an influence on disease severity and susceptibility in rheumatoid arthritis (RA). Studies were undertaken to define the effect of RA-associated alleles on disease severity in Korean patients with seropositive RA. The results indicate that the most common RA susceptibility allele, HLA-DRB1*0405, is significantly associated with bony erosion, joint deformity and extra-articular manifestations. However, RA-associated alleles in Koreans have less effect on nodular disease than in Caucasians. This suggests that the presence of RA-associated alleles, especially HLA-DRB1*0405, seems to be a prognostic marker for severe erosive disease in Koreans.
authors.affiliation: Department of Internal Medicine, Rheumatism Centre of Kangnam St Mary's Hospital, Catholic University Medical College, Seoul, Korea.
authors.forename: H Y
authors.initials: HY
authors.lastname: Kim
authors.forename: J K
authors.initials: JK
authors.lastname: Min
authors.forename: H I
authors.initials: HI
authors.lastname: Yang
authors.forename: S H
authors.initials: SH
authors.lastname: Park
authors.forename: Y S
authors.initials: YS
authors.lastname: Hong
authors.forename: W H
authors.initials: WH
authors.lastname: Jee
authors.forename: S H
authors.initials: SH
authors.lastname: Lee
authors.forename: C S
authors.initials: CS
authors.lastname: Cho
authors.forename: T G
authors.initials: TG
authors.lastname: Kim
authors.forename: H
authors.initials: H
authors.lastname: Han
mesh_terms: D000328:Adult; D000483:Alleles; D001172:Arthritis, Rheumatoid / Q000453:epidemiology*; D005260:Female; D006684:HLA-DR Antigens / Q000235:genetics / Q000502:physiology*; D059811:HLA-DRB1 Chains; D006801:Humans; D007723:Korea / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index
chemical_list: D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains