Verrucosis of hands and feet in a patient with combined immune deficiency.
In immunocompromised patients, warts occur frequently and can be extensive. We describe a 24-year-old patient with severe therapy-resistant warts. In addition to human papillomavirus infection, he had chronic sinusitis, candidiasis, and atopic dermatitis. Anergy to delayed-type hypersensitivity skin test reaction, significant CD4 lymphopenia, and diminished in vitro T-cell proliferative response and interferon-gamma production indicated a deficiency of cellular immunity. Extremely low concentrations of serum IgM and IgG2 and a severe deficiency of in vitro IgM production pointed also to a humoral immunodeficiency syndrome. This case represents a combination of cellular and humoral immunodeficiencies that has not been previously described in association with warts.
Asadullah
K
K
Department of Dermatology, University Hospital Charité, Berlin, Germany.
Renz
H
H
Döcke
W D
WD
Otterbach
H
H
Wahn
U
U
Köttgen
E
E
Volk
H D
HD
Sterry
W
W
D000328:Adult; D018791:CD4 Lymphocyte Count; D005533:Foot Dermatoses / Q000150:complications*; D006229:Hand Dermatoses / Q000150:complications*; D006801:Humans; D017099:IgG Deficiency / Q000150:complications; D007075:Immunoglobulin M / Q000172:deficiency; D007153:Immunologic Deficiency Syndromes / Q000150:complications* / Q000276:immunology; D008297:Male; D027383:Papillomaviridae; D014412:Tumor Virus Infections / Q000150:complications*; D014860:Warts / Q000150:complications*
D007075:Immunoglobulin M