[The role of the muscarinic receptors in the pathogenesis of the convulsive state induced by korazol in rats].
It was established in experiments on albino rats that blockade of the muscarinic receptors by various M-cholinolytics reduces the dose of corazol necessary for the development of a convulsive state. Preliminary administration of some cholinopositive agents raises the corazol action threshold. It is suggested on the basis of pharmacological analysis that the role of the cholinergic system in the pathogenesis of corasol-induced convulsive state in rats is mediated by the function of cholinoreceptors related to subtype M4 or M1.
Khobotova
Z I
ZI
Mukovskiĭ
L A
LA
Kosmachev
A B
AB
Fil'ko
O A
OA
Filippov
V N
VN
Dolgo-Saburov
V B
VB
D000818:Animals; D003292:Convulsants / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D016014:Linear Models; D018727:Muscarinic Antagonists / Q000494:pharmacology; D010433:Pentylenetetrazole / Q000494:pharmacology*; D051381:Rats; D011976:Receptors, Muscarinic / Q000187:drug effects / Q000502:physiology*; D012640:Seizures / Q000209:etiology*; D013997:Time Factors
D003292:Convulsants; D018727:Muscarinic Antagonists; D011976:Receptors, Muscarinic; D010433:Pentylenetetrazole
Rol' muskarinovykh retseptorov v patogeneze sudorozhnogo sostoianiia, vyzvannogo korazolom u krys.