[Hypolipidemic effect of sulfated polysaccharides].
In experiments on hyperlipidemic rats it was observed the hypolipidemic effect of new sulfated polisaccharides-chitosan, lutelan and krilan sulfates, More pronounced decrease was established in VLDL and increase of HDL after sulfated polysaccharides treatment. The most distinct efficiency exhibites preparation with moledular mass of 20-40 x 10(3) D and the rate of sulfation 9-14%.
Ryzhenkov
V E
VE
Solov'eva
M A
MA
Remezova
O V
OV
Okunevich
I V
IV
D000818:Animals; D002686:Chitin / Q000031:analogs & derivatives / Q000494:pharmacology / Q000633:toxicity; D048271:Chitosan; D003902:Detergents / Q000633:toxicity; D006949:Hyperlipidemias / Q000139:chemically induced / Q000517:prevention & control*; D000960:Hypolipidemic Agents / Q000494:pharmacology* / Q000633:toxicity; D007928:Lethal Dose 50; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D051379:Mice; D011092:Polyethylene Glycols / Q000633:toxicity; D011134:Polysaccharides / Q000494:pharmacology* / Q000633:toxicity; D051381:Rats; D013431:Sulfates / Q000494:pharmacology / Q000633:toxicity; D014461:Ultracentrifugation
D003902:Detergents; D000960:Hypolipidemic Agents; D008074:Lipoproteins; D011134:Polysaccharides; D013431:Sulfates; D002686:Chitin; D011092:Polyethylene Glycols; D048271:Chitosan; C016811:tyloxapol
Gipolipidemicheskoe deĭstvie sul'fatirovannykh polisakharidov.