Modern medical management of endometriosis.
The modern medical management of endometriosis has changed considerably since the first attempts were made to control this disease hormonally over four decades ago. Currently, there are multiple choices for the clinician and patient, including oral contraceptives, danazol, GnRH agonist analogues, and gestrinone. Several advances have been made in the use of GnRH agonists in preventing some of the untoward effects of prolonged hypoestrogenism. These add-back regimens provide the best therapy available today for prolonged medical control of endometriotic symptoms. The antiprogesterones (RU-486) hold promise for the future, but are still in the investigational stage of development.
Kettel
L M
LM
Department of Reproductive Medicine, University of California, San Diego, USA.
Hummel
W P
WP
D003613:Danazol / Q000627:therapeutic use; D004715:Endometriosis / Q000188:drug therapy*; D004965:Estrogen Antagonists / Q000627:therapeutic use; D015914:Estrogen Replacement Therapy; D005260:Female; D005867:Gestrinone / Q000627:therapeutic use; D007987:Gonadotropin-Releasing Hormone / Q000037:antagonists & inhibitors; D006727:Hormone Antagonists / Q000627:therapeutic use; D006801:Humans; D015735:Mifepristone / Q000627:therapeutic use; D045167:Progesterone Congeners / Q000627:therapeutic use
D004965:Estrogen Antagonists; D006727:Hormone Antagonists; D045167:Progesterone Congeners; D005867:Gestrinone; D015735:Mifepristone; D007987:Gonadotropin-Releasing Hormone; D003613:Danazol