title: Echinococcus multilocularis: mouse strain difference in hydatid development.
abstract: Female mice of nine inbred strains (A, AKR, BALB/c, C3H, C57BL/6, C57BL/10, CBA, DBA/1 and DBA/2) and H-2 congenic B10.D2, at 9-10 weeks of age, were infected with larval Echinococcus multilocularis by trans-portal injection of hydatid homogenate. Parasitized livers were histologically examined 9 or 13 weeks after infection. Hydatid development was quite different among mouse strains. Multivesiculation was prominent in C57BL/10, DBA/1, C57BL/6 and BALB/c. Protoscoleces were well developed in DBA/2, AKR, DBA/1 and CBA. H-2 congenic B10.D2, which has the background genes of C57BL/10 except for the H-2d gene of DBA/2, resembled C57BL/10 in prohibiting the development of protoscoleces. These data suggest that the qualitative difference in hydatid development may be regulated by non-H-2 gene(s).
authors.affiliation: Animal Laboratory for Medical Research, Asahikawa Medical College, Asahikawa 078, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Nakaya
authors.forename: M
authors.initials: M
authors.lastname: Nakao
authors.forename: A
authors.initials: A
authors.lastname: Ito
mesh_terms: D000818:Animals; D004444:Echinococcosis, Hepatic / Q000469:parasitology*; D004446:Echinococcus / Q000254:growth & development*; D005260:Female; D006790:Host-Parasite Interactions; D051379:Mice; D008815:Mice, Inbred Strains / Q000469:parasitology*; D013045:Species Specificity