Initiation and processing of signals from the B cell antigen receptor.
Current models of signal transduction from the antigen receptors on B and T cells still resemble equations with several unknown elements. Data from recent knockout experiments in cell lines and mice contradict the assumption that Src-family kinase and tyrosine kinases of the Syk/Zap-70 family are the transducer elements that set signaling from these receptors in motion. Using a functional definition of signaling elements, we discuss the current knowledge of signaling events from the BCR and suggest the existence of an as-yet-unknown BCR transducer complex.
Reth
M
M
Department of Molecular Immunology, Biology III, University Freiburg, Germany. reth@immunbio.mpg.de
Wienands
J
J
D000818:Animals; D005075:Biological Evolution; D006801:Humans; D051379:Mice; D008954:Models, Biological; D017027:Protein Tyrosine Phosphatases / Q000378:metabolism; D011505:Protein-Tyrosine Kinases / Q000378:metabolism; D011947:Receptors, Antigen, B-Cell / Q000378:metabolism*; D015398:Signal Transduction
D011947:Receptors, Antigen, B-Cell; D011505:Protein-Tyrosine Kinases; D017027:Protein Tyrosine Phosphatases