[Behavior of postoperative adhesions after intraperitoneal administration of fibrinolytic drugs in a rat model].
In a rat model, the effect of the intraperitoneal application of fibrinolytic agents on the development of adhesions was examined. Streptokinase and TPA reduced sero-serosal adhesions significantly, whereas urokinase did not reduce them. Intravascular coagulation was not affected.
Stapel
A
A
Klinik und Poliklinik für Allgemeinchirurgie, Medizinische Hochschule Hannover.
Geissler
N
N
Mlasowsky
B
B
Jung
D
D
D000818:Animals; D005260:Female; D005343:Fibrinolytic Agents / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D010537:Peritoneum / Q000187:drug effects / Q000473:pathology / Q000601:surgery*; D051381:Rats; D017208:Rats, Wistar; D013300:Streptokinase / Q000494:pharmacology*; D000267:Tissue Adhesions / Q000473:pathology; D010959:Tissue Plasminogen Activator / Q000494:pharmacology*; D014568:Urokinase-Type Plasminogen Activator / Q000494:pharmacology*
D005343:Fibrinolytic Agents; D013300:Streptokinase; D010959:Tissue Plasminogen Activator; D014568:Urokinase-Type Plasminogen Activator
Verhalten postoperativer Adhäsionen nach intraperitonealer Applikation von Fibrinolytika in einem Rattenmodell.