[Mechanism on androgen-independent progression of prostate cancer].
Eighty percent of prostate cancer with metastasis respond to androgen ablasion, showing initial androgen-sensitive growth. However, more than half of responders gradually loses dependency up to 5 years. Animal experiments reveal that loss of androgen sensitivity is attributable to complex reasons; adaptation, paracrine control by other androgen-independent tissues, genetic changes and mutation of androgen receptor. Most important event is explained from alteration of expression on oncogenes and suppressor genes. Counterplan of the progression was discussed.
Shimazaki
J
J
Department of Urology, School of Medicine, Chiba University.
Akakura
K
K
Furuya
Y
Y
Ito
H
H
D000726:Androgen Antagonists / Q000627:therapeutic use*; D000728:Androgens / Q000502:physiology*; D000818:Animals; D018450:Disease Progression; D019008:Drug Resistance, Neoplasm; D015972:Gene Expression Regulation, Neoplastic; D016147:Genes, Tumor Suppressor; D006801:Humans; D008297:Male; D009154:Mutation; D009919:Orchiectomy; D011471:Prostatic Neoplasms / Q000235:genetics / Q000473:pathology* / Q000628:therapy; D011944:Receptors, Androgen / Q000235:genetics; D014407:Tumor Cells, Cultured
D000726:Androgen Antagonists; D000728:Androgens; D011944:Receptors, Androgen