title: Evaluation of the Mycobacterium leprae particle agglutination (MLPA) test as a tool in the epidemiology of leprosy in high prevalence village in South Sulawesi, Indonesia.
abstract: This study reports on the usefulness of an IgM phenolic glycolipid-1 (PGL-1) Mycobacterium leprae particle agglutination (MLPA) test for serodiagnosis of leprosy in a prospective longitudinal community survey in a high prevalence village in South Sulawesi, Indonesia, IgM PGL-1 MLPA has simple and limited value as a screening method for detection of transmission of leprosy in the community. Many normal persons in the community in a high prevalence area had increased IgM anti PGL-1 antibodies, presumably as a consequence of early subclinical infection. In conclusion, this study demonstrated that the MLPA test can only reliably detect anti-PGL-1 antibodies in the community and may be useful for follow-up study of subclinical infection of leprosy among individuals living the an endemic area.
authors.affiliation: Department of Medical Microbiology, Faculty of Medicine, Hasanuddin University, Ujung Pandang, Indonesia.
authors.forename: M
authors.initials: M
authors.lastname: Hatta
authors.forename: S
authors.initials: S
authors.lastname: Izumi
authors.forename: P R
authors.initials: PR
authors.lastname: Klatser
mesh_terms: D000293:Adolescent; D000328:Adult; D000907:Antibodies, Bacterial / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood*; D007214:Indonesia / Q000453:epidemiology; D007223:Infant; D007841:Latex Fixation Tests / Q000592:standards*; D007918:Leprosy / Q000175:diagnosis* / Q000453:epidemiology / Q000276:immunology; D008297:Male; D008403:Mass Screening / Q000379:methods; D008875:Middle Aged; D009166:Mycobacterium leprae / Q000276:immunology*; D015995:Prevalence; D011446:Prospective Studies; D016036:Seroepidemiologic Studies; D018881:Suburban Health
chemical_list: D000907:Antibodies, Bacterial; D007075:Immunoglobulin M