Helicobacter pylori and intestinal metaplasia of gastric mucosa.
BACKGROUND
The role of Helicobacter pylori in stomach carcinogenesis is currently under study. H pylori-related chronic gastritis leading to dysplasia or intestinal metaplasia (IM) especially of the colonic type is postulated as one of the mechanisms.


METHODS
We studied 120 patients with or without H pylori infection to determine the frequency of occurrence of IM in the stomach.


RESULTS
IM was found in 16.6% of patients; most cases had the small intestinal type, which is not known to have a malignant potential. There was no relation between H pylori infection and development of IM.


CONCLUSIONS
H pylori infection leading to IM does not appear to be a factor in the genesis of carcinoma stomach in our population.
Satarkar
R P
RP
Department of Gastroenterology, LTMG Hospital, Mumbai.
Sawant
P
P
Nanivadekar
S
S
Shroff
C
C
D000328:Adult; D004379:Duodenal Neoplasms / Q000453:epidemiology / Q000209:etiology* / Q000473:pathology; D005069:Evaluation Studies as Topic; D005260:Female; D005753:Gastric Mucosa / Q000473:pathology*; D016481:Helicobacter Infections / Q000150:complications* / Q000473:pathology; D016480:Helicobacter pylori / Q000302:isolation & purification*; D006801:Humans; D015994:Incidence; D007194:India / Q000453:epidemiology; D007413:Intestinal Mucosa / Q000473:pathology; D008297:Male; D008679:Metaplasia; D008875:Middle Aged; D011230:Precancerous Conditions / Q000473:pathology*; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000453:epidemiology / Q000209:etiology* / Q000473:pathology