title: [Echo-guided biopsy of the transitional zone in the diagnosis of prostatic carcinoma].
abstract: Approximately 24% of prostate cancer originate in transition zone. To define the indications for transition zone biopsies from April 1994 to February 1996 we evaluated 112 men ranging in age from 56 to 84 years (mean 67.4). 94 patients presented elevated PSA levels and normal rectal examination (24 with negative prior systematic sextant biopsies). A group included 6 patients with palpable nodularity and normal PSA levels. A third group consisted of 12 men with sonographic abnormalities. Of the 112 patients evaluated 38 (34%) were found to have cancer on the prostate biopsies and 7 (18%) were positive only in sample of transition zone biopsies. We conclude that transition zone biopsies don't substantially improve the cancer detection rates in patients with palpable nodularity or sonographic abnormalities but are useful in patients with elevated PSA levels and/or negative prior systematic sextant biopsies.
authors.affiliation: Cattedra di Urologia, Università degli Studi di Bari.
authors.forename: A
authors.initials: A
authors.lastname: Pagliarulo
authors.forename: C
authors.initials: C
authors.lastname: Curatolo
authors.forename: E
authors.initials: E
authors.lastname: Cirillo Marucco
authors.forename: A
authors.initials: A
authors.lastname: Lorusso
authors.forename: D A
authors.initials: DA
authors.lastname: Limitone
authors.forename: G M
authors.initials: GM
authors.lastname: Ludovico
mesh_terms: D000230:Adenocarcinoma / Q000097:blood / Q000000981:diagnostic imaging / Q000473:pathology*; D000368:Aged; D000369:Aged, 80 and over; D000951:Antigens, Neoplasm / Q000097:blood; D014408:Biomarkers, Tumor / Q000097:blood; D001707:Biopsy, Needle / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011467:Prostate / Q000000981:diagnostic imaging* / Q000473:pathology*; D017430:Prostate-Specific Antigen / Q000097:blood; D011471:Prostatic Neoplasms / Q000097:blood / Q000000981:diagnostic imaging / Q000473:pathology*; D012189:Retrospective Studies; D014463:Ultrasonography
chemical_list: D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D017430:Prostate-Specific Antigen
vernacular_title: La biopsia ecoguidata della zona di transizione nella diagnosi di carcinoma prostatico.