Studies on the "signal" constituents for the evaluation of animal crude drugs. III. Nucleic acid components.
An analytical method for determining the contents of 7 nucleic acid bases, 6 ribonucleosides and 5 deoxyribonucleosides in animal crude drugs were established. The contents in free nucleic acid components (the ice-cold extracts) and in total nucleic acid components (the heated extracts) of 8 crude drugs were quite different from one another, indicating that these content patterns could be used as a "signal" of each animal crude drug. For example, the contents of inosine in Lumbricus, uracil in Cervi Parvum Cornu, and guanine and hypoxanthine in Hippocampus were high. The total contents in each crude drug were about twice or three times as large as the free contents. The main degradation products by the heated extracts were adenine and guanine. These results suggested that the contents of nucleic acid components could be one of the "signal" constituents for evaluation of animal crude drugs.
Hashimoto
A
A
Analytical Research Laboratory, Tanabe Seiyaku Co., Ltd., Osaka, Japan.
Nakamura
T
T
Kokusenya
Y
Y
Nakai
H
H
Sato
T
T
D000818:Animals; D008419:Materia Medica / Q000737:chemistry*; D008516:Medicine, Chinese Traditional; D009696:Nucleic Acids / Q000032:analysis*; D009835:Oligochaeta / Q000737:chemistry
D008419:Materia Medica; D009696:Nucleic Acids