Linkage analysis between schizophrenia and the Darier's disease region on 12q.
There have been reports of an association between Darier's disease, an autosomal dominant genodermatosis, and psychiatric illness. Recently the gene causing Darier's disease has been mapped to an area on 12q, between D12S58 and D12S84. The findings of linkage analysis of 4 markers in the Darier's disease region on 12q in five families segregating schizophrenia are presented. They fail to support close linkage between schizophrenia and the Darier's disease region on 12q.
O'Malley
M P
MP
Division of Dermatology, University of Toronto, Ontario, Canada.
Bassett
A S
AS
Honer
W G
WG
Kennedy
J L
JL
King
N
N
Berg
D
D
D000328:Adult; D002874:Chromosome Mapping; D002881:Chromosomes, Human, Pair 12; D007644:Darier Disease / Q000235:genetics*; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D008126:Lod Score; D008957:Models, Genetic; D009679:Nuclear Family; D011618:Psychotic Disorders / Q000235:genetics; D012559:Schizophrenia / Q000235:genetics*
D005819:Genetic Markers