Cavum septi pellucidi in normals and patients with schizophrenia as detected by magnetic resonance imaging.
Cavum septi pellucidi (CSP) is a cavity between the two leaflets of the septum pellucidum. CSP is a developmental anomaly, yet the pathologic implications, if any, of an abnormally large CSP remain unclear. The reported incidence of CSP among normal populations varies greatly from 0.15% to 85%. Several studies have suggested that there is a higher incidence of CSP in patients with schizophrenia. We conducted a thin-slice magnetic resonance imaging study to evaluate the prevalence of CSP in a sample of 75 controls and 55 patients. There was a high incidence of small CSP among both groups: 58.8% in the controls and 58.2% in the patients, suggesting that a small cavum could be considered a normal variant; however, the patient group had significantly higher incidence of large CSP (20.7%) compared to the normal group (3%). The patients with large CSP were all male.
Nopoulos
P
P
Mental Health Clinical Research Center, University of Iowa College of Medicine, Iowa City, USA.
Swayze
V
V
Flaum
M
M
Ehrhardt
J C
JC
Yuh
W T
WT
Andreasen
N C
NC
D000328:Adult; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D012559:Schizophrenia; D012688:Septum Pellucidum / Q000033:anatomy & histology*