Dose response relationship between occupational PAH exposure and lung cancer--an overview.
Epidemiologic cohort and case-referent studies have shown an increased risk of lung cancer among various PAH-exposed occupations, such as coke, coal gas and aluminium production workers, road pavers, roofers and chimney sweeps. In different cohort studies, a positive dose response relationship between PAH exposure time and lung cancer have been described. On some workers, a relationship was found between coal for pitch volatiles (CTPV) and the risk of lung cancer. A doubling dose for lung cancer of > 20 [(mg CTPV/m3) years] or > 100 [micrograms BaP/m3) years] has been found among coke and aluminium production workers. Acknowledgement of lung cancer as an occupational disease is proposed after a cumulative dose of > 20 [(mg CTPV/m3) years] or > 100 [micrograms BaP/m3) years].
Bolm-Audorff
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Hesse Ministry for Women, Labour and Social Welfare, Department of Occupational Safety, Wiesbaden, Germany.
D002617:Chemical Industry; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008175:Lung Neoplasms / Q000139:chemically induced*; D009784:Occupational Diseases / Q000139:chemically induced*; D016273:Occupational Exposure; D011084:Polycyclic Aromatic Hydrocarbons / Q000009:adverse effects*
D011084:Polycyclic Aromatic Hydrocarbons