title: Alteration of renal blood flow during epidural anesthesia in normal subjects.
abstract: The cardiovascular consequences of epidural anesthesia secondary to sympathetic blockade are well documented; however, their repercussions on renal hemodynamics in humans have not been reported. We investigated the effect of epidural anesthesia on renal blood flow (RBF) in 13 healthy volunteers 18-45 yr of age. RBF was measured using paraaminohippurate clearance before and after bilateral T6 epidural sensory block (to ensure adequate sympathetic renal nerve blockade). Epidural anesthesia was established using 22 +/- 3 mL of 2% plain lidocaine (without epinephrine) via L1-L2 epidural catheter; urine output was measured using a three-way Foley catheter. Mean arterial pressure remained > or = 70 mm Hg in all subjects without any pharmacologic intervention. Mean RBF before epidural anesthesia was 16.1 +/- 6.8 mL.kg-1.min-1 and 14.3 +/- 2.9 mL.kg-1.min-1 after bilateral T6 epidural blockade. We conclude that the institution of epidural anesthesia in healthy subjects does not result in a significant change in RBF (P > 0.25).
authors.affiliation: Department of Anesthesiology, University of North Carolina Hospitals, Chapel Hill, USA.
authors.forename: M Y
authors.initials: MY
authors.lastname: Suleiman
authors.forename: A N
authors.initials: AN
authors.lastname: Passannante
authors.forename: R L
authors.initials: RL
authors.lastname: Onder
authors.forename: W F
authors.initials: WF
authors.lastname: Greene-Helms
authors.forename: S G
authors.initials: SG
authors.lastname: Perretta
mesh_terms: D000293:Adolescent; D000328:Adult; D000767:Anesthesia, Epidural; D000779:Anesthetics, Local; D001794:Blood Pressure; D005260:Female; D006339:Heart Rate; D006801:Humans; D007668:Kidney / Q000294:innervation; D007677:Kidney Function Tests; D008012:Lidocaine; D008297:Male; D008875:Middle Aged; D009407:Nerve Block; D012016:Reference Values; D012079:Renal Circulation; D010130:p-Aminohippuric Acid
chemical_list: D000779:Anesthetics, Local; D008012:Lidocaine; D010130:p-Aminohippuric Acid