title: Early biologic behavior of bone grafts. A fine needle aspiration cytology study.
abstract: OBJECTIVE
  To conceptualize, with fine needle aspiration cytology (FNAC), the early cellular events occurring in and around fresh autogenous and allogenic bone grafts during the first 40 postimplantation days.
  
  
  METHODS
  Forty-eight cases of bone grafts were studied by FNAC at serial intervals of 10, 20, 30 and 40 postimplantation days. Twenty patients were recipients of autogenous grafts, 16 received 0.6N HCI partially decalcified allogenic bone implants, and 4 received combined autogenous and allogenic bone grafts (included in the allograft group). There were eight control cases of closed fracture shaft femur, which were managed conservatively.
  
  
  RESULTS
  The initial cellular responses in autogenous grafts, allografts and controls appear to be a part of the nonspecific reparative process followed by a more specific phase, with a steady increase in relative lymphocyte count from the 20th day onwards. Osteogenesis, as judged by osteoblasts and osteoclasts, was also comparable.
  
  
  CONCLUSIONS
  Partially decalcified allografts appear to be a good substitute for autogenous bone grafts in clinical practice when adequate autogenous material is not available. FNAC is a good technique for studying bone graft responses without interfering with graft uptake. It is helpful in the early detection of subclinical infection or any other pathology at the graft site.
authors.affiliation: Department of Orthopaedics, University College of Medical Sciences, Delhi, India.
authors.forename: M
authors.initials: M
authors.lastname: Garg
authors.forename: G
authors.initials: G
authors.lastname: Dev
authors.forename: K
authors.initials: K
authors.lastname: Misra
authors.forename: S M
authors.initials: SM
authors.lastname: Tuli
mesh_terms: D000293:Adolescent; D000328:Adult; D001707:Biopsy, Needle; D016025:Bone Transplantation / Q000000981:diagnostic imaging / Q000502:physiology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D018655:Lymphocyte Count; D008297:Male; D008875:Middle Aged; D010012:Osteogenesis / Q000502:physiology; D011859:Radiography; D013997:Time Factors; D014182:Transplantation, Autologous; D014184:Transplantation, Homologous