title: Origin and progression of thyroid epithelial tumours: cellular and molecular mechanisms.
abstract: Tumours of the thyroid follicular cell are proving to be one of the most informative models for "dissecting' the molecular genetics of multi-stage human tumorigenesis. Early thyroid tumour development is closely correlated with mutation of five alternative genes, ras, ret, trk, gsp and the TSH receptor, associated with different tumour phenotypes, providing an excellent example of genotype/phenotype correlation. For two of these genes, ras and ret, there is also direct experimental evidence from gene transfer studies that they are sufficient to initiate tumorigenesis, one of very few situations where such proof of causality has been obtained for a human tumour. Much less is known of the molecular basis of malignant transformation in thyroid. However, the rare, further progression to undifferentiated (anaplastic) cancer provides a particularly clear-cut illustration of the role of the tumour-suppressor gene p53 in human cancer. Furthermore, in vitro data suggest the intriguing possibility that the anaplastic phenotype results from a combination of p53 mutation together with a spontaneous switch in differentiation programme, i.e. co-operation between a genetic and an epigenetic event.
authors.affiliation: Department of Pathology, University of Wales College of Medicine, Cardiff, UK.
authors.forename: D
authors.initials: D
authors.lastname: Wynford-Thomas
mesh_terms: D000236:Adenoma / Q000235:genetics; D000818:Animals; D002291:Carcinoma, Papillary / Q000235:genetics; D016158:Genes, p53; D006801:Humans; D011519:Proto-Oncogenes; D013964:Thyroid Neoplasms / Q000235:genetics*