[Activity of endogenous anticoagulants (antithrombin III, protein C and protein S) in women after menopause treated with hormone replacement therapy (transdermal 17 beta-OH estradiol and oral medroxyprogesterone acetate)].
The influence of hormone replacement therapy (HRT) on coagulation system has not been completely explained yet. We measured plasma activities of antithrombin III, protein C and protein S before and after 6 and 12 months of HRT in 48 postmenopausal women. HRT consisted of transdermal estradiol and orally medroxyprogesterone acetate. We observed no statistically significant differences in plasma levels of the above endogenous anticoagulants before and during treatment.
Ciepłuch
R
R
Oddziału Ginekologii i Połoznictwa Szpitala Miejskiego, Gdyni.
Czestochowska
E
E
D000368:Aged; D000990:Antithrombin III / Q000187:drug effects* / Q000378:metabolism; D004958:Estradiol / Q000494:pharmacology*; D015914:Estrogen Replacement Therapy; D005260:Female; D006023:Glycoproteins / Q000187:drug effects* / Q000378:metabolism; D006801:Humans; D017258:Medroxyprogesterone Acetate / Q000494:pharmacology*; D008875:Middle Aged; D017698:Postmenopause / Q000187:drug effects* / Q000378:metabolism; D011486:Protein C / Q000187:drug effects / Q000378:metabolism; D017293:Protein S / Q000187:drug effects / Q000378:metabolism
D006023:Glycoproteins; D011486:Protein C; D017293:Protein S; D004958:Estradiol; D000990:Antithrombin III; D017258:Medroxyprogesterone Acetate
Aktywność endogennych antykoagulantów (antytrombiny III, białka C i białka S) u kobiet po menopauzie leczonych hormonalna terapia zastepcza (17 beta-OH estradiol przezskórnie i octan medroksyprogesteronu doustnie).