How can be best explain retrograde amnesia in human memory disorder?
I firstly consider general issues relating to our attempts to understand retrograde amnesia. Three main hypotheses are reviewed that have been proposed to account for retrograde amnesia. A theory is outlined to explain the dense autobiographical amnesia that is a focal phenomenon in some cases of severe head injury. This theory postulates that autobiographical retrieval requires the activation of a distributed network of cognitive operations, and that autobiographical amnesia results from the occurrence of multiple areas of pathology, distributed over both space and time.
Kapur
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Wessex Neurological Centre, Southampton General Hospital, UK.
D000367:Age Factors; D017668:Age of Onset; D000648:Amnesia, Retrograde / Q000503:physiopathology*; D001921:Brain / Q000503:physiopathology*; D001930:Brain Injuries / Q000503:physiopathology; D006801:Humans; D008568:Memory / Q000502:physiology; D008960:Models, Psychological; D013997:Time Factors