Noninvasive monitoring of hemodynamic changes in acute pancreatitis in rabbits.
Hemodynamic parameters of experimental acute necrotizing pancreatitis (AP) were monitored by means of echocardiography in rabbits. Left ventricular (LV) systolic and diastolic parameters were determined before and 1, 3, 6, 12, 18, and 24 hr after injection of taurocholic acid in the pancreatic duct in AP animals. Temporary LV dilatation was observed 6 hr after the AP induction [LV end-diastolic (ED) diameter from 1.16 +/- 0.04 to 1.22 +/- 0.04 cm, P < 0.05, ED volume from 2.98 +/- 0.34 to 3.57 +/- 0.75 ml, P < 0.05] without decrease in systolic function. Cardiac output (CO) and stroke volume (StV) was increased in both groups 3 hr after the operation (from 0.53 +/- 0.15 to 0.71 +/- 0.06 L/min, P < 0.05 in AP), but in the AP animals it remained high. However, 24 hr after AP induction, both the CO and the StV were decreased significantly. The LV diastolic function was impaired 1 hr after AP induction, but had recovered after 12 hr. In conclusion, an early diastolic impairment followed by LV enlargement could be noninvasively observed in experimental AP in rabbits.
Gyöngyösi
M
M
2nd Department of Internal Medicine, Albert Szent-Györgyi Medical University, Szeged, Hungary.
Takács
T
T
Czakó
L
L
Jambrik
Z
Z
Boda
K
K
Farkas
A
A
Forster
T
T
Csanády
M
M
D000208:Acute Disease; D000818:Animals; D003971:Diastole / Q000502:physiology; D004452:Echocardiography; D006439:Hemodynamics / Q000502:physiology*; D017379:Hypertrophy, Left Ventricular / Q000000981:diagnostic imaging / Q000503:physiopathology*; D008991:Monitoring, Physiologic; D010195:Pancreatitis / Q000139:chemically induced / Q000000981:diagnostic imaging / Q000503:physiopathology*; D011817:Rabbits; D013656:Taurocholic Acid; D013997:Time Factors; D016277:Ventricular Function, Left / Q000502:physiology
D013656:Taurocholic Acid