Isometric handgrip exercise increases endothelin-1 plasma levels in patients with chronic congestive heart failure.
This study demonstrated an immediate and short-lasting endothelin-1 release in the circulation of patients with severe chronic congestive heart failure during isometric handgrip exercise, but not in normal subjects. Our data suggest that endothelin-1 levels may increase transiently during daily physical activity, thus contributing to progressive deterioration of left ventricular function.
Mangieri
E
E
II Cattedra di Cardiologia, Istituto di Chirurgia del Cuore e Grossi Vasi, Università La Sapienza, Rome, Italy.
Tanzilli
G
G
Barillà
F
F
Ciavolella
M
M
Serafini
G
G
Nardi
M
M
Mangiaracina
F
F
Scibilia
G
G
Dell'Italia
L J
LJ
Campa
P P
PP
D000328:Adult; D000704:Analysis of Variance; D002908:Chronic Disease; D019332:Endothelin-1 / Q000097:blood*; D015444:Exercise / Q000502:physiology*; D018737:Hand Strength / Q000502:physiology*; D006333:Heart Failure / Q000503:physiopathology*; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D016277:Ventricular Function, Left / Q000502:physiology
D019332:Endothelin-1