Multiple endocrine neoplasia type 1 and the search for the genetic trigger.
Multiple endocrine neoplasia type 1 (MEN-1) is characterized by primary hyperparathyroidism, endocrine pancreatic-duodenal and anterior pituitary tumors. The diagnosis is challenging and involves the exclusion of other endocrine neoplasia syndromes with overlapping features. The predisposing genetic defect was assigned to chromosomal region 11q13 based on linkage analysis. Combined tumor and pedigree genotype analysis showed that allele losses in pancreatic, parathyroid and pituitary tumors eliminated the wild-type allele at the 11q13 loci, suggesting inactivation of a tumor suppressor gene in this region. A 5-Mb integrated map of the region has been established by the European consortium on MEN-1. Based on this mapping the critical interval was restricted to 2 Mb, a region within which eight candidate genes are located.
Farnebo
F
F
Department of Molecular Medicine, Karolinska Hospital, Stockholm, Sweden.
Järhult
J
J
Farnebo
L O
LO
Nilsson
O
O
Teh
B T
BT
Lagercrantz
J
J
Weber
G
G
Sandelin
K
K
Larsson
C
C
D002874:Chromosome Mapping; D002880:Chromosomes, Human, Pair 11; D003937:Diagnosis, Differential; D016147:Genes, Tumor Suppressor; D006801:Humans; D018761:Multiple Endocrine Neoplasia Type 1 / Q000175:diagnosis / Q000235:genetics*; D010375:Pedigree