Gene expression profiles in normal and cancer cells.
As a step toward understanding the complex differences between normal and cancer cells in humans, gene expression patterns were examined in gastrointestinal tumors. More than 300,000 transcripts derived from at least 45,000 different genes were analyzed. Although extensive similarity was noted between the expression profiles, more than 500 transcripts that were expressed at significantly different levels in normal and neoplastic cells were identified. These data provide insight into the extent of expression differences underlying malignancy and reveal genes that may prove useful as diagnostic or prognostic markers.
Zhang
L
L
Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
Zhou
W
W
Velculescu
V E
VE
Kern
S E
SE
Hruban
R H
RH
Hamilton
S R
SR
Vogelstein
B
B
Kinzler
K W
KW
D015179:Colorectal Neoplasms / Q000235:genetics; D003198:Computer Simulation; D004068:Digestive System Physiological Phenomena; D005770:Gastrointestinal Neoplasms / Q000235:genetics*; D015870:Gene Expression; D006801:Humans; D012016:Reference Values; D014407:Tumor Cells, Cultured