Cutaneous necrotizing vasculitis associated with hepatitis A virus infection.
Hepatitis A virus has been recognized as an etiologic factor of cutaneous necrotizing vasculitis in only 2 adult cases. We describe a 2-year-old Bedouin girl who developed cutaneous necrotizing vasculitis during the acute phase of hepatitis A infection. The cutaneous punch biopsy from an ecchymotic lesion revealed microscopic findings of a necrotizing vasculitis process involving the superficial and deep blood vessel plexuses. Fibrin thrombi were present in the lumen of a few blood vessels. She was treated with 2 mg/kg/day, tapered during 5 weeks. Serum liver enzymes returned to the normal range within 6 weeks of the first presenting symptom. A few skin scars were noted in previously necrotic areas. Hepatitis A is one of many viruses that may be an etiologic factor in development of cutaneous necrotizing vasculitis in children.
Press
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Pediatric Emergency Room, Soroka Medical Center, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Maslovitz
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Avinoach
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D000208:Acute Disease; D001706:Biopsy; D002675:Child, Preschool; D002921:Cicatrix / Q000821:virology; D005260:Female; D006506:Hepatitis A / Q000150:complications*; D006801:Humans; D009336:Necrosis; D017445:Skin Diseases, Vascular / Q000473:pathology / Q000821:virology*; D014657:Vasculitis / Q000473:pathology / Q000821:virology*