Asymmetrical regulation of blood pressure in the rat medulla.
The effects of microinjection of serotonin-1 (5-HT1) antagonist methiothepin and 5-HT1 agonist buspirone into the nucleus reticularis parvocellularis were investigated in the anaesthetized rats. Methiothepin produced an increase in arterial blood pressure when injected into the left side, but it did a decrease when injected into the right side. On the contrary, buspirone produced a decrease in arterial blood pressure when injected into the left side, but it did an increase when injected into the right side. These findings provide the clue to clarify that there is a reciprocal regulation of arterial blood pressure between the left and right sides in the rat medulla.
Shiozaki
T
T
Department of Neurosurgery, Kinki University School of Medicine, Osaka-Sayama, Osaka, Japan.
Taneda
M
M
Yasuda
M
M
Kim
A J
AJ
D000818:Animals; D001794:Blood Pressure / Q000502:physiology*; D002065:Buspirone / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D007839:Functional Laterality / Q000502:physiology; D008297:Male; D008526:Medulla Oblongata / Q000502:physiology*; D008719:Methiothepin / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012702:Serotonin Antagonists / Q000494:pharmacology*; D017366:Serotonin Receptor Agonists / Q000494:pharmacology
D012702:Serotonin Antagonists; D017366:Serotonin Receptor Agonists; D008719:Methiothepin; D002065:Buspirone