title: The relationship between cortical injury and brain tumour. Report of two cases and review of the literature.
abstract: We report on two cases of brain tumour and discuss the possible relationship to previous cortical trauma. The first patient, a 67-year-old male patient developed a glioblastoma at the same site of an open shell-splinter injury of the brain after a latency of 48 years. The second patient, a 55-year-old male, had a malignant anaplastic astrocytoma in the right frontal lobe 10 years after clipping of an aneurysm of the anterior communicating artery. Both cases fulfill the criteria of Zülch [52] for the correlation between cortical trauma and tumour. We believe that the development of a brain tumour following a cortical injury is very rare, although possible. Probably the brain must display some form of predisposing genetic alteration for a tumour to develop following a cortical injury.
authors.affiliation: Department of Neurosurgery, Benjamin Franklin Medical Center, Free University of Berlin, Federal Republic of Germany.
authors.forename: R
authors.initials: R
authors.lastname: Stendel
authors.forename: A
authors.initials: A
authors.lastname: Théallier-Jankó
authors.forename: T
authors.initials: T
authors.lastname: Höll
authors.forename: M
authors.initials: M
authors.lastname: Brock
mesh_terms: D000368:Aged; D001254:Astrocytoma / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D001930:Brain Injuries / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D002540:Cerebral Cortex / Q000293:injuries* / Q000473:pathology / Q000601:surgery; D005500:Follow-Up Studies; D005909:Glioblastoma / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D006801:Humans; D002532:Intracranial Aneurysm / Q000473:pathology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D012307:Risk Factors; D014948:Wounds, Gunshot / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery