title: A genomewide linkage study of preeclampsia/eclampsia reveals evidence for a candidate region on 4q.
abstract: Preeclampsia (PE) and eclampsia (E) are potentially life-threatening conditions that can occur during human pregnancy. Generally considered to be different degrees of severity of the same disease process, the PE/E syndrome is thought to be predominantly genetic in origin, although its exact etiology and genetics are not fully understood. Here we report results of a genomewide linkage search for the gene(s) responsible for susceptibility to PE/E, using 15 informative pedigrees and 90 polymorphic DNA markers from all autosomes. Because of uncertainties concerning inheritance and diagnosis, four different models that assume maternal gene expression have been used to carry out LOD-score analysis. The region between D4S450 and D4S610 (2.8 cM) on the long arm of chromosome 4 was identified as a strong candidate region for a PE/E-susceptibility locus. The maximum multipoint LOD score within this interval was 2.9. Analysis of markers in the region around D4S450 and D4S610 by the affected-pedigree-member method also supported the possibility of a susceptibility locus in this region. However, to verify or exclude definitively linkage to this region, other groups of PE/E pedigrees will be required.
authors.affiliation: School of Biological Sciences, Macquarie University, North Ryde, New South Wales, Australia.
authors.forename: G A
authors.initials: GA
authors.lastname: Harrison
authors.forename: K E
authors.initials: KE
authors.lastname: Humphrey
authors.forename: N
authors.initials: N
authors.lastname: Jones
authors.forename: R
authors.initials: R
authors.lastname: Badenhop
authors.forename: G
authors.initials: G
authors.lastname: Guo
authors.forename: G
authors.initials: G
authors.lastname: Elakis
authors.forename: J A
authors.initials: JA
authors.lastname: Kaye
authors.forename: R J
authors.initials: RJ
authors.lastname: Turner
authors.forename: M
authors.initials: M
authors.lastname: Grehan
authors.forename: A N
authors.initials: AN
authors.lastname: Wilton
authors.forename: S P
authors.initials: SP
authors.lastname: Brennecke
authors.forename: D W
authors.initials: DW
authors.lastname: Cooper
mesh_terms: D001315:Australia; D002894:Chromosomes, Human, Pair 4; D004461:Eclampsia / Q000235:genetics*; D005260:Female; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D006801:Humans; D008126:Lod Score; D008957:Models, Genetic; D010375:Pedigree; D011225:Pre-Eclampsia / Q000235:genetics*; D011247:Pregnancy; D013577:Syndrome
chemical_list: D005819:Genetic Markers