title: Cell cycle and apoptosis: possible roles of Gadd45 and MyD118 proteins inferred from their homology to ribosomal proteins.
abstract: The function and structure of many disease gene products are currently poorly understood, and the easiest way to proceed is to search databases for homologous proteins to infer function or structure from the closest database match. Bioinformatics provides a variety of methods that reach beyond the standard database searches with single query sequences. The identification of a large superfamily of ribosome-associated proteins by computer analysis enabled Eugene Koonin to infer functional information for Gadd45, which is part of a cell-cycle checkpoint pathway defective in ataxia-telangiectasia.
authors.affiliation: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA.
authors.forename: E V
authors.initials: EV
authors.lastname: Koonin
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000943:Antigens, Differentiation; D017209:Apoptosis; D002453:Cell Cycle; D016208:Databases, Factual; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D051379:Mice; D008969:Molecular Sequence Data; D011506:Proteins / Q000235:genetics* / Q000502:physiology; D012269:Ribosomal Proteins / Q000235:genetics*; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D000097642:GADD45 Proteins
chemical_list: D000943:Antigens, Differentiation; D047908:Intracellular Signaling Peptides and Proteins; D011506:Proteins; D012269:Ribosomal Proteins; D000097642:GADD45 Proteins; C086470:GADD45B protein, human; C490125:Gadd45b protein, mouse; C034212:ribosomal protein S12