title: Psychosocial development and premorbid skeletal growth in Legg-Calvé-Perthes disease: a study of nineteen patients.
abstract: We studied psychosocial development and skeletal growth in 19 newly diagnosed patients with Legg-Calvé-Perthes disease (LCPD). Eleven patients had problems in visuospatial skills and five of 12 school-aged children had learning difficulties. The growth velocity of the patients was evaluated from 4 years before until 2 years after the diagnosis was made. Eight patients had a catch-up growth with +1.2 (0.9-1.7) delta SDS score (SDS: mean and ranges) before the diagnosis. Four patients with short stature and retarded bone age slightly diminished their growth velocity. Overnight serum growth hormone (GH) concentration and insulin-like growth factor I (IGF-I) levels were examined in the first nine consecutive patients. One patient had a high and another had a low mean GH concentration level, whereas all patients had IGF-I levels within normal limits. These results suggest that different kinds of growth disturbances may be associated with LCPD.
authors.affiliation: Children's Hospital, Helsinki, Finland.
authors.forename: T T
authors.initials: TT
authors.lastname: Lahdes-Vasama
authors.forename: I S
authors.initials: IS
authors.lastname: Sipilä
authors.forename: S
authors.initials: S
authors.lastname: Lamminranta
authors.forename: S H
authors.initials: SH
authors.lastname: Pihko
authors.forename: E O
authors.initials: EO
authors.lastname: Merikanto
authors.forename: E J
authors.initials: EJ
authors.lastname: Marttinen
mesh_terms: D002648:Child; D002675:Child, Preschool; D002658:Developmental Disabilities / Q000209:etiology*; D005260:Female; D006128:Growth; D013006:Growth Hormone / Q000097:blood; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000032:analysis; D007859:Learning Disabilities / Q000150:complications; D007873:Legg-Calve-Perthes Disease / Q000097:blood / Q000150:complications* / Q000473:pathology / Q000523:psychology; D008297:Male; D009483:Neuropsychological Tests; D010468:Perceptual Disorders / Q000150:complications; D011603:Psychophysiology; D014796:Visual Perception
chemical_list: D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone