Specific protein recognition of an mRNA cap through its alkylated base.
The specific binding of N7-methylguanine cap analogues to the RNA methyltransferase VP39 was observed through X-ray crystallography, providing a prototypical structure for a complex between a protein and an mRNA 5' cap.
Hodel
A E
AE
Gershon
P D
PD
Shi
X
X
Wang
S M
SM
Quiocho
F A
FA
D000478:Alkylation; D001665:Binding Sites; D018360:Crystallography, X-Ray; D008780:Methyltransferases / Q000737:chemistry*; D012314:RNA Cap Analogs / Q000737:chemistry; D014764:Viral Proteins / Q000737:chemistry*
D012314:RNA Cap Analogs; C088682:VP39 protein, Vaccinia virus; D014764:Viral Proteins; D008780:Methyltransferases; C052744:RNA 2'-O-methyltransferase