title: The immunogenicity of Haemophilus influenzae: meningococcal protein conjugate vaccine in Polynesian and non-Polynesian New Zealand infants.
abstract: OBJECTIVE
  To examine the comparative immunogenicity of the Haemophilus influenzae type b-meningococcal protein (PRP-OMP) conjugate vaccine in Polynesian and non-Polynesian New Zealand infants.
  
  
  METHODS
  Fifty-six Polynesian and 53 non-Polynesian infants aged 2-7 months recruited from primary health care settings in Auckland received a two-dose primary series of PRP-OMP. A sub-sample of 83 participants received a booster dose of PRP-OMP at 12-16 months of age. Anti-PRP antibody concentrations were measured in pre- and post-vaccination blood samples.
  
  
  RESULTS
  Antibody responses consistent with long-term protection (> or = 1.00 microgram/mL) were observed in 72, 85 and 95% of children following the first, second and booster doses.
  
  
  CONCLUSIONS
  Despite differences in disease epidemiology, PRP-OMP was highly immunogenic in Polynesian and non-Polynesian infants.
authors.affiliation: Department of Paediatrics, School of Medicine, University of Auckland, New Zealand.
authors.forename: S N
authors.initials: SN
authors.lastname: Ameratunga
authors.forename: D R
authors.initials: DR
authors.lastname: Lennon
authors.forename: B
authors.initials: B
authors.lastname: Entwistle
authors.forename: E
authors.initials: E
authors.lastname: Robinson
authors.forename: R V
authors.initials: RV
authors.lastname: Ameratunga
mesh_terms: D000917:Antibody Formation; D016009:Chi-Square Distribution; D003430:Cross-Sectional Studies; D005500:Follow-Up Studies; D006192:Haemophilus Infections / Q000453:epidemiology / Q000208:ethnology / Q000276:immunology* / Q000517:prevention & control; D018073:Haemophilus Vaccines / Q000276:immunology*; D006801:Humans; D007115:Immunization Schedule; D007223:Infant; D008137:Longitudinal Studies; D015999:Multivariate Analysis; D009520:New Zealand / Q000453:epidemiology / Q000208:ethnology; D011114:Polynesia / Q000208:ethnology
chemical_list: D018073:Haemophilus Vaccines