Hepatic cells' mitotic and peritoneal macrophage phagocytic activities during Trypanosoma musculi infection in zinc-deficient mice.
The effects of zinc deficiency on hepatic cell mitotic and peritoneal macrophage phagocytic activities were examined in mice infected with Trypanosoma musculi or immunized with parasitic products. On a full-complement or pair-fed diet, infected and homogenate-inoculated mice showed mitotic activity gains of 7.9% to 80.3% and 6.5% to 99.0%, respectively. Infected and homogenate-inoculated mice on a zinc-deficient diet showed 21.8% to 95.7% and 17.2% to 65.2%, respectively, more dividing liver cells compared with controls. In comparison to controls, macrophages isolated from infected and homogenate-immunized mice on full-complement or pair-fed diets had phagocytized 13.4% to 31.4% more latex particles from day 50 to 80. In the zinc-deficient group, macrophages isolated from infected mice had significant numbers of phagocytized latex particles (1.8% to 38.5%) from day 20 to day 80 compared with controls. The homogenate-immunized mice also had increased numbers (18.6 to 30.8%) of phagocytized latex particles.
Humphrey
P A
PA
Department of Biology, Howard University, Washington, DC 20059, USA.
Ashraf
M
M
Lee
C M
CM
D000818:Animals; D005260:Female; D008099:Liver / Q000473:pathology*; D017737:Macrophages, Peritoneal / Q000276:immunology*; D051379:Mice; D008938:Mitosis; D010587:Phagocytosis; D014352:Trypanosomiasis / Q000150:complications / Q000276:immunology* / Q000473:pathology; D015032:Zinc / Q000172:deficiency* / Q000502:physiology
D015032:Zinc