Reduced expression of SLA Class 1 antigens by intestinal epithelium of newborn piglets.
Expression of major histocompatibility complex Class 1 by the small intestine mucosa of piglets was compared by indirect immunofluorescence during the 4 days following birth with both maternal and artificial feeding. The duodenal epithelium did not express Class I antigen during these 4 days. The jejunal epithelium did not express Class I antigen at Day 0 after birth but expression developed from Day 1. However ileal epithelium expressed Class 1 antigen throughout the study period. In contrast, cells from the lamina propria of all samples expressed Class 1 antigen. There was no difference between piglets receiving maternal colostrum and artificially reared piglets. This lack of Class 1 expression occurs at a time when the intestinal epithelium constitutes an interface between piglet and colostral maternal cells. This can be of biological relevance for mother-newborn interactions.
Le Jan
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I.N.R.A. Laboratoire de Pathologie Infectieuse et Immunologie, Nouzilly, France.
Chevaleyre
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D000821:Animal Feed; D000818:Animals; D000831:Animals, Newborn; D000911:Antibodies, Monoclonal; D003126:Colostrum / Q000276:immunology; D004386:Duodenum / Q000276:immunology / Q000378:metabolism; D004848:Epithelium / Q000276:immunology / Q000378:metabolism; D019084:Fluorescent Antibody Technique, Indirect; D015395:Histocompatibility Antigens Class I; D007413:Intestinal Mucosa / Q000276:immunology* / Q000378:metabolism; D007583:Jejunum / Q000276:immunology / Q000378:metabolism; D007633:Keratins / Q000378:metabolism; D007962:Leukocytes / Q000276:immunology; D013154:Spleen / Q000276:immunology; D013552:Swine; D013556:Swine, Miniature / Q000276:immunology* / Q000378:metabolism
D000911:Antibodies, Monoclonal; D015395:Histocompatibility Antigens Class I; D007633:Keratins