title: New aporphine alkaloids and cytotoxic constituents of Hernandia nymphaeifolia.
abstract: Two new aporphine alkaloids, (+)-N-hydroxyhernangerine (1) and N-formyldehydroovigerine (2) as minor bases, along with four known aporphines, (+)-magnoflorine, (+)-hernovine, (+)-N-methylhernovine, and (+)-laurotetanine, two known isoquinolones, thalifoline and northalifoline, and one benzylisoquinoline, (+)-reticuline, have been additionally isolated from the trunk bark of Hernandia nymphaeifolia. The structures of these compounds were elucidated by spectroscopic evidence. Six of the isolated compounds show significant cytotoxic activities (ED50 values < 1 microgram/ml) against P-388, KB16, A549, or HT-29 cell lines.
authors.affiliation: Graduate Institute of Pharmaceutical Sciences, Kaohsiung Medical College, Taiwan, Republic of China.
authors.forename: I S
authors.initials: IS
authors.lastname: Chen
authors.forename: J J
authors.initials: JJ
authors.lastname: Chen
authors.forename: C Y
authors.initials: CY
authors.lastname: Duh
authors.forename: I L
authors.initials: IL
authors.lastname: Tsai
authors.forename: C T
authors.initials: CT
authors.lastname: Chang
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology*; D001060:Aporphines; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D013056:Spectrophotometry, Ultraviolet; D014197:Trees / Q000737:chemistry*; D014407:Tumor Cells, Cultured
chemical_list: D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D001060:Aporphines; C081279:aporphine