title: DnaA initiator--also a transcription factor.
abstract: The replication-initiator protein DnaA is ubiquitous in the eubacterial world. It binds to an asymmetric 9 bp consensus DNA sequence, the DnaA box. Besides its primary function as an initiator, it acts as a transcription factor that represses or activates several genes, or terminates transcription, depending on the location and arrangement of DnaA boxes.
authors.affiliation: Max-Planck-Institut für Molekulare Genetik, Berlin (Dahlem), Germany. messer@mpimg-berlin-dahlem.mpg.de
authors.forename: W
authors.initials: W
authors.lastname: Messer
authors.forename: C
authors.initials: C
authors.lastname: Weigel
mesh_terms: D001426:Bacterial Proteins / Q000378:metabolism*; D004247:DNA; D004261:DNA Replication; D004268:DNA-Binding Proteins / Q000378:metabolism*; D012097:Repressor Proteins / Q000378:metabolism*; D015534:Trans-Activators; D014157:Transcription Factors / Q000378:metabolism*; D014158:Transcription, Genetic
chemical_list: D001426:Bacterial Proteins; D004268:DNA-Binding Proteins; C066312:DnaA protein, Bacteria; D012097:Repressor Proteins; D015534:Trans-Activators; D014157:Transcription Factors; D004247:DNA