title: The influence of ifosfamide scheduling on acute nephrotoxicity in children.
abstract: Nephrotoxicity is a significant problem in children after treatment with ifosfamide. Acute changes in renal function were compared in 16 children receiving 9 g m(-2) of ifosfamide as a 72-h continuous infusion on one occasion and, on another course, divided into three 1-h infusions on consecutive days. Subclinical acute nephrotoxicity was demonstrated with both schedules, but there were no significant differences in severity.
authors.affiliation: Sir James Spence Institute of Child Health, The Royal Victoria Infirmary, Newcastle upon Tyne, UK.
authors.forename: M W
authors.initials: MW
authors.lastname: English
authors.forename: R
authors.initials: R
authors.lastname: Skinner
authors.forename: A D
authors.initials: AD
authors.lastname: Pearson
authors.forename: L
authors.initials: L
authors.lastname: Price
authors.forename: R
authors.initials: R
authors.lastname: Wyllie
authors.forename: A W
authors.initials: AW
authors.lastname: Craft
mesh_terms: D000293:Adolescent; D018906:Antineoplastic Agents, Alkylating / Q000008:administration & dosage / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D003404:Creatinine / Q000097:blood; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007069:Ifosfamide / Q000008:administration & dosage / Q000627:therapeutic use*; D007223:Infant; D007262:Infusions, Intravenous; D007668:Kidney / Q000187:drug effects* / Q000473:pathology / Q000503:physiopathology; D007677:Kidney Function Tests; D008297:Male; D009369:Neoplasms / Q000188:drug therapy; D016482:Urinalysis
chemical_list: D018906:Antineoplastic Agents, Alkylating; D003404:Creatinine; D007069:Ifosfamide