Urgent liver transplantation for biliary atresia: the experience in Bicêtre.
According to French rules for cadaver organ sharing, children with biliary atresia (BA) complicated with acute necrosis (ALN) can be registered on the waiting list for liver transplantation (LT) in a special intermediate grade urgent code. Over a 7 years period, 100 children have been submitted to elective LT for BA and 15 to urgent LT. Urgent procedures accounted for 25% of LT for BA in patients aged 0-2 years and 67% (8/12) in patients under 1 year of age. Children actuarial survival at 1, 12 and 48 months was respectively 66%, 60% and 60% versus 92%, 86% and 85%, deaths occurring earlier in the urgent group. Graft actuarial survival at 1, 12 and 48 months were 60%, 53% and 53% versus 85%, 77% and 76% (p < 0.05), respectively. Outcome of children and grafts after LT is not significantly different in BA cases and in other urgent indications, excluding retransplantations. In a LT program based on cadaver organ donation, allocation of in an urgent registration code to children with BA and ALN offers them more than 50% chance to escape death and does not result in wasting of grafts.
Gauthier
F
F
Service de Chirurgie Pédiatrique, Centre Hospitalier Universitaire Bicêtre, Faculté de Médecine Paris Sud, Université Paris 11, Le Kremlin Bicêtre, France.
Chardot
C
C
Branchereau
S
S
Okawa
Y
Y
de Dreuzy
O
O
Jacolot
D
D
Devictor
D
D
Debray
D
D
Valayer
J
J
D000206:Actuarial Analysis; D000367:Age Factors; D001656:Biliary Atresia / Q000473:pathology / Q000601:surgery*; D002675:Child, Preschool; D005260:Female; D006085:Graft Survival; D006801:Humans; D007223:Infant; D008099:Liver / Q000473:pathology; D016031:Liver Transplantation; D008297:Male; D011171:Portoenterostomy, Hepatic; D011183:Postoperative Complications; D015996:Survival Rate; D016896:Treatment Outcome