title: Five-year follow-up of high-risk infants with family history of allergy who were exclusively breast-fed or fed partial whey hydrolysate, soy, and conventional cow's milk formulas.
abstract: BACKGROUND
  Allergy is a common cause of illness. The effect of feeding different infant formulas on the incidence of atopic disease and food allergy was assessed in a prospective randomized double-blind study of high-risk infants with a family history of atopy.
  
  
  METHODS
  216 high-risk infants whose mothers had elected not to breast-feed were randomized to receive exclusively a partial whey hydrolysate formula or a conventional cow's milk formula or a soy formula until 6 months of age. Seventy-two high risk infants breast-fed for > or = 4 months were also studied.
  
  
  RESULTS
  Follow-up until 5 years of age showed a significant lowering in the cumulative incidence of atopic disease in the breast-fed (odds ratio 0.422 [0.200-0.891]) and the whey hydrolysate (odds ratio 0.322 [0.159-0.653) groups, compared with the conventional cow's milk group. Soy formula was not effective (odds ratio 0.759 [0.384-1.501]). The occurrence of both eczema and asthma was lowest in the breast-fed and whey hydrolysate groups and was comparable in the cow's milk and soy groups. Similar significant differences were noted in the 18-60 month period prevalence of eczema and asthma. Eczema was less severe in the whey hydrolysate group compared with the other groups. Double-blind placebo-controlled food challenges showed a lower prevalence of food allergy in the whey hydrolysate group compared with the other formula groups.
  
  
  CONCLUSIONS
  Exclusive breast-feeding or feeding with a partial whey hydrolysate formula is associated with lower incidence of atopic disease and food allergy. This is a cost-effective approach to the prevention of allergic disease in children.
authors.affiliation: Department of Pediatrics, Memorial University of Newfoundland, Canada.
authors.forename: R K
authors.initials: RK
authors.lastname: Chandra
mesh_terms: D000818:Animals; D001249:Asthma / Q000517:prevention & control; D001942:Breast Feeding; D004311:Double-Blind Method; D004485:Eczema / Q000517:prevention & control; D005500:Follow-Up Studies; D005512:Food Hypersensitivity / Q000517:prevention & control; D006801:Humans; D006967:Hypersensitivity / Q000453:epidemiology / Q000517:prevention & control*; D007223:Infant; D007225:Infant Food; D007231:Infant, Newborn; D008892:Milk; D008894:Milk Proteins; D010919:Placebos; D011446:Prospective Studies; D012307:Risk Factors; D013025:Glycine max; D000067816:Whey Proteins
chemical_list: D008894:Milk Proteins; D010919:Placebos; D000067816:Whey Proteins