Characterization of T cells transmigrating through human endothelial cells in patients with HTLV-I-associated myelopathy.
We investigated the surface markers as well as the expression of beta 2-integrin (LFA-1 beta/CD 18), in T cells migrating through human umbilical vein endothelial cells (EC) in patients with HTLV-I-associated myelopathy (HAM). No significant differences were found in the percentages of both HLA-DR+ T cells and total CD4+ cells and in the expression of beta 2-integrin between the EC-transmigrated and the EC adherent T cells. However, the percentages of HLA-DR+CD4+ cells in the transmigrated cells were significantly higher than those in the adherent cells. These results suggest that activated or HLA-DR+CD4+ T cells play an important role as the first trigger in the immunopathogenesis of HAM.
Ichinose
K
K
First Department of Internal Medicine, Nagasaki University School of Medicine, Japan.
Nakamura
T
T
Nishiura
Y
Y
Tsujino
A
A
Goto
H
H
Shirabe
S
S
Furuya
T
T
Nagataki
S
S
D000328:Adult; D000368:Aged; D018821:CD18 Antigens / Q000096:biosynthesis; D018791:CD4 Lymphocyte Count; D002465:Cell Movement / Q000276:immunology*; D002478:Cells, Cultured; D003470:Culture Media; D004730:Endothelium, Vascular / Q000166:cytology / Q000276:immunology*; D005260:Female; D006684:HLA-DR Antigens / Q000096:biosynthesis; D015368:Human T-lymphotropic virus 1; D006801:Humans; D008213:Lymphocyte Activation; D008297:Male; D008875:Middle Aged; D015493:Paraparesis, Tropical Spastic / Q000276:immunology*; D013601:T-Lymphocytes / Q000737:chemistry* / Q000378:metabolism / Q000502:physiology*; D014471:Umbilical Veins
D018821:CD18 Antigens; D003470:Culture Media; D006684:HLA-DR Antigens