title: Exchange transfusion with red blood cells preserved in adenine clears a child of severe falciparum malaria.
abstract: Falciparum malaria may be associated with significant morbidity and mortality. The degree of mortality and morbidity usually corresponds to the degree of parasitemia. Quinine and other antimalarial drugs are relatively slow acting and not always effective owing to the presence of drug resistance falciparum. Rapid reduction of the number of circulating parasites may be required. Exchange transfusion has been used as a safe and quick approach to decreasing the parasitemia and antimalaria drugs used to eradicate the rest of the Plasmodium. In the present report, a case is described of a child with severe falciparum malaria who was successfully treated with exchange transfusion using the new adenine and mannitol enriched preservative media, Adsol.
authors.affiliation: Department of Pathology, Bronx-Lebanon Hospital Center, NY 10457, USA.
authors.forename: F N
authors.initials: FN
authors.lastname: Boctor
authors.forename: N M
authors.initials: NM
authors.lastname: Ali
authors.forename: Y J
authors.initials: YJ
authors.lastname: Choi
authors.forename: E E
authors.initials: EE
authors.lastname: Morse
mesh_terms: D000225:Adenine; D001793:Blood Preservation; D002648:Child; D005078:Exchange Transfusion, Whole Blood; D005260:Female; D005869:Ghana; D005947:Glucose; D006801:Humans; D016778:Malaria, Falciparum / Q000628:therapy*; D008353:Mannitol; D010949:Plasma; D012965:Sodium Chloride
chemical_list: C037839:ADSOL; D008353:Mannitol; D012965:Sodium Chloride; D005947:Glucose; D000225:Adenine