title: Pathophysiology of chest trauma.
abstract: Recent information indicates that there is a complex cellular and molecular generic response to injury that can lead to multi-organ failure. For many years, basic physiology and biochemistry were considered to be the systemic mechanisms to injury, but now it is known that subcellular and molecular events are the keys to unlocking the secrets of the body's response to trauma. The interaction of the endothelial cell with neutrophils and platelets to produce cytokines, free radicals, and upregulating adhesion molecules is especially significant.
authors.affiliation: Department of Surgery, University of Texas Health Science Center at San Antonio, USA.
authors.forename: J H
authors.initials: JH
authors.lastname: Calhoon
authors.forename: J K
authors.initials: JK
authors.lastname: Trinkle
mesh_terms: D000328:Adult; D001810:Blood Volume; D002302:Cardiac Output; D006801:Humans; D009102:Multiple Organ Failure / Q000503:physiopathology; D012121:Respiration, Artificial; D012128:Respiratory Distress Syndrome / Q000503:physiopathology; D018746:Systemic Inflammatory Response Syndrome / Q000503:physiopathology; D013898:Thoracic Injuries / Q000503:physiopathology*; D014949:Wounds, Nonpenetrating / Q000503:physiopathology*; D014950:Wounds, Penetrating / Q000503:physiopathology*