title: [An immunohistochemical study of the expression of transcription factor Oct3/4 in mouse spermatogenesis].
abstract: The expression of POU-domain transcription factor Oct3/4 in the testis of adult mice has been studied using indirect immunofluorescence with highly specific antibodies. The protein is shown to be expressed in germ cells of seminiferous epithelium in a stage specific manner. The protein synthesis is initiated in mid-pachytene spermatocytes, increases to reach its peak during meiotic division. The Oct3/4 level remains augmented in early spermatids, but gradually declines during their further developmental advancement. These findings imply that Oct3/4 may have a regulatory function providing for the control of meiosis and/or terminal differentiation of spermatogenic cells.
authors.forename: A N
authors.initials: AN
authors.lastname: Tomilin
authors.forename: E I
authors.initials: EI
authors.lastname: Kostyleva
authors.forename: M A
authors.initials: MA
authors.lastname: Drosdovskiĭ
authors.forename: J E
authors.initials: JE
authors.lastname: Seralini
authors.forename: V I
authors.initials: VI
authors.lastname: Vorob'ev
mesh_terms: D000818:Animals; D004847:Epithelial Cells; D019084:Fluorescent Antibody Technique, Indirect; D005786:Gene Expression Regulation / Q000502:physiology*; D006238:Haploidy; D008297:Male; D008540:Meiosis / Q000502:physiology; D051379:Mice; D013091:Spermatogenesis / Q000502:physiology*; D013737:Testis / Q000166:cytology / Q000378:metabolism; D013997:Time Factors; D014157:Transcription Factors / Q000096:biosynthesis*
chemical_list: D014157:Transcription Factors
vernacular_title: Immunogistokhimicheskoe issledovanie ékspressii transkriptsionnogo faktora Oct3/4 v spermatogeneze myshi.