Lamotrigine therapy in infantile neuronal ceroid lipofuscinosis (INCL).
Since 1990, altogether 16 INCL patients received lamotrigine (LTG) because of intractable epilepsy. The response to LTG was favorable in 15/16 children. The severity of seizures decreased significantly in 15/16 patients, the frequency of seizures decreased in 14/16, and the effects were maintained. In addition, LTG had a beneficial effect on the well-being of 14/16 children. LTG failed to maintain it's efficacy in monotherapy. No severe side effects were found.
Aberg
L
L
Children's Hospital, University of Helsinki.
Heiskala
H
H
Vanhanen
S L
SL
Himberg
J J
JJ
Hosking
G
G
Yuen
A
A
Santavuori
P
P
D000293:Adolescent; D000328:Adult; D000927:Anticonvulsants / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D004359:Drug Therapy, Combination; D004569:Electroencephalography / Q000187:drug effects; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D000077213:Lamotrigine; D009460:Neurologic Examination / Q000187:drug effects; D009472:Neuronal Ceroid-Lipofuscinoses / Q000188:drug therapy*; D016896:Treatment Outcome; D014227:Triazines / Q000627:therapeutic use*
D000927:Anticonvulsants; D014227:Triazines; D000077213:Lamotrigine