Genetic renal mechanisms of hypertension.
An update on renal genetic mechanisms of spontaneous hypertension in rats and in human essential hypertension is presented. The findings are discussed, highlighting the search of a possible link between the discovered genetic abnormality and the renal function changes that may determine the disease. The analogies (and/or differences) between the numerous positive findings obtained in animal models and the relatively scarce ones obtained in humans are discussed.
Cusi
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Division of Nephrology, Dialysis and Hypertension and Postgraduate School of Nephrology, University of Milano, S. Raffaele Hospital, Italy.
D000808:Angiotensinogen / Q000235:genetics; D000818:Animals; D009320:Atrial Natriuretic Factor / Q000235:genetics; D002148:Calmodulin-Binding Proteins / Q000235:genetics; D042926:Cytochrome P-450 CYP4A; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics; D016232:Endothelins / Q000235:genetics; D005190:Family; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D006899:Mixed Function Oxygenases / Q000235:genetics; D008955:Models, Cardiovascular; D019001:Nitric Oxide Synthase / Q000235:genetics; D007703:Peptidyl-Dipeptidase A / Q000235:genetics; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D017461:Receptors, Atrial Natriuretic Factor / Q000235:genetics; D012083:Renin / Q000235:genetics; D015222:Sodium Channels / Q000235:genetics; D000099291:Adducins
D000808:Angiotensinogen; D009320:Atrial Natriuretic Factor; D002148:Calmodulin-Binding Proteins; D042926:Cytochrome P-450 CYP4A; D003577:Cytochrome P-450 Enzyme System; D016232:Endothelins; D006899:Mixed Function Oxygenases; D019001:Nitric Oxide Synthase; D007703:Peptidyl-Dipeptidase A; D017461:Receptors, Atrial Natriuretic Factor; D012083:Renin; D015222:Sodium Channels; D000099291:Adducins