title: [Tolerance of +Gx-loads by females before and after a 120-day hypokinesia].
abstract: The goal of the work was to study female tolerance of g-loads before and after simulated weightlessness, and evaluate the effectiveness of countermeasures and anti-g means proposed for space flight. Centrifuge with a 7.25 m arm was used for 29 runs of 8 female subjects. The subjects were exposed to the transverse loads (+GX) at 8.2 g on a special regimen with the total run time of 9 min to simulate the ballistic descent from orbit in a SOYUZ-TM vehicle. Baseline tolerance of the females to transverse loads up to +8GX was good and satisfactory. Following 120 days of bed rest without the countermeasures or the anti-g suit g-tolerance was significantly lowered as evidenced by visual disorders in 67% of cases and exaggerated, if compared with the pre-hypokinesia levels, heart and respiration rates, i.e. 20% and 23.5%, respectively. The countermeasures and anti-g suit Centaur maintained g-tolerance at essentially the baseline level and precluded visual disorders. Results of the study speak in favor of the countermeasures and anti-g means used by the females in simulated long-duration weightlessness which can be recommended for the final phase of extended space mission.
authors.affiliation: State Scientific Center "Institute of Medico-Biological Problems", Russian Federation.
authors.forename: V I
authors.initials: VI
authors.lastname: Luk'ianiuk
authors.forename: A R
authors.initials: AR
authors.lastname: Kotovskaia
authors.forename: M I
authors.initials: MI
authors.lastname: Koloteva
authors.forename: I F
authors.initials: IF
authors.lastname: Vil'-Vil'iams
authors.forename: L N
authors.initials: LN
authors.lastname: Gavrilova
authors.forename: A S
authors.initials: AS
authors.lastname: Iarov
authors.forename: S G
authors.initials: SG
authors.lastname: Kriutchenko
authors.forename: V V
authors.initials: VV
authors.lastname: Kleev
authors.forename: M N
authors.initials: MN
authors.lastname: Balakhonov
mesh_terms: D000222:Adaptation, Physiological / Q000502:physiology*; D000328:Adult; D000337:Aerospace Medicine; D004562:Electrocardiography; D005260:Female; D005500:Follow-Up Studies; D006439:Hemodynamics; D006801:Humans; D018471:Hypergravity; D018476:Hypokinesia / Q000150:complications / Q000503:physiopathology*; D012123:Pulmonary Ventilation; D012016:Reference Values; D014786:Vision Disorders / Q000209:etiology / Q000503:physiopathology; D014796:Visual Perception; D014893:Weightlessness
vernacular_title: Perenosimost' peregruzok napravleniia +Gx zhenshchinami do i posle 120-sutochnoi gipokinezii.