title: Rapid regeneration of power stroke in contracting muscle by attachment of second myosin head.
abstract: When Lombardi and colleagues reported the phenomenon of rapid regeneration of the power stroke after a quick release of muscle fibre during a tetanus, they gave an explanation in terms of detachment of cross-bridges and re-attachment further along the thin filament. We show here that the phenomenon can also be explained on assumptions that lead to a majority of myosin molecules being attached by only one head during steady isometric contraction; the other head may then become attached after a quick release and can add its contribution to the early tension recovery after a second release.
authors.affiliation: Physiological Laboratory, University of Cambridge, UK.
authors.forename: A F
authors.initials: AF
authors.lastname: Huxley
authors.forename: S
authors.initials: S
authors.lastname: Tideswell
mesh_terms: D007537:Isometric Contraction; D008954:Models, Biological; D009119:Muscle Contraction / Q000502:physiology*; D009218:Myosins / Q000502:physiology*; D012984:Software
chemical_list: D009218:Myosins