Protein functions in pre-mRNA splicing.
Proteins have been implicated in an expanding variety of functions during pre-mRNA splicing. Molecular cloning has identified genes encoding spliceosomal proteins that potentially act as novel RNA helicases, GTPases, or protein isomerases. Novel protein-protein and protein-RNA interactions that are required for functional spliceosome formation have also been described. Finally, growing evidence suggests that proteins may contribute directly to the spliceosome's active sites.
Will
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CL
Institut für Molekularbiologie und Tumorforschung, Philipps Universität Marburg, Emil Mannkopff Strasse 2, 35037, Marburg, Germany. will@imt.uni-marburg.de
Lührmann
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R
D005656:Fungal Proteins / Q000378:metabolism; D046911:Macromolecular Substances; D011485:Protein Binding; D012322:RNA Precursors / Q000378:metabolism*; D012326:RNA Splicing; D012331:RNA, Fungal / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism; D012261:Ribonucleoproteins / Q000502:physiology; D017411:Ribonucleoproteins, Small Nuclear / Q000502:physiology*; D012441:Saccharomyces cerevisiae; D017381:Spliceosomes / Q000502:physiology*
D005656:Fungal Proteins; D046911:Macromolecular Substances; D012322:RNA Precursors; D012331:RNA, Fungal; D012333:RNA, Messenger; D012261:Ribonucleoproteins; D017411:Ribonucleoproteins, Small Nuclear