Systemic complement activation in psoriasis vulgaris.
Nineteen patients with psoriasis vulgaris and no other cause for systemic complement activation were studied for evidence of such activation. There was a marked elevation in serum C5b-9 complexes with no other significant complement abnormalities, and no correlation between C5b-9 levels and disease activity. This is the most detailed study of complement in psoriasis yet attempted and confirms that complement activation is a feature of psoriasis vulgaris.
Fleming
C J
CJ
University Department of Dermatology, Western Infirmary, Glasgow, Scotland, UK.
Holme
E R
ER
Mackie
R M
RM
D000293:Adolescent; D000328:Adult; D000368:Aged; D003167:Complement Activation; D015938:Complement Membrane Attack Complex / Q000032:analysis*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000276:immunology* / Q000473:pathology; D012720:Severity of Illness Index
D015938:Complement Membrane Attack Complex