Transposable elements: how non-LTR retrotransposons do it.
The source of the enzyme activity responsible for the transposition of retrotransposons of the type that lack terminal repeats has at last been identified: in L1Hs elements, it is encoded by the second open reading frame and is a nuclease related to the apurinic repair endonucleases.
Finnegan
D J
DJ
Institute of Cell and Molecular Biology, University of Edinburgh, Edinburgh, EH9 3JR, UK.
D000818:Animals; D004260:DNA Repair / Q000235:genetics; D043603:DNA-(Apurinic or Apyrimidinic Site) Lyase; D043223:Deoxyribonuclease IV (Phage T4-Induced); D004331:Drosophila melanogaster / Q000235:genetics / Q000821:virology; D015750:Genes, gag; D015751:Genes, pol; D006801:Humans; D008190:Lyases / Q000378:metabolism; D008957:Models, Genetic; D008979:Moloney murine leukemia virus / Q000235:genetics; D016366:Open Reading Frames; D012194:RNA-Directed DNA Polymerase / Q000378:metabolism; D012091:Repetitive Sequences, Nucleic Acid; D018626:Retroelements; D012190:Retroviridae / Q000235:genetics*; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000821:virology; D017384:Sequence Deletion
D018626:Retroelements; D012194:RNA-Directed DNA Polymerase; D043223:Deoxyribonuclease IV (Phage T4-Induced); D008190:Lyases; D043603:DNA-(Apurinic or Apyrimidinic Site) Lyase