Interaction of ciprofloxacin with diclofenac and paracetamol in relation to it's epileptogenic effect.
A number of fluoroquinolones have shown convulsive potential. The effect of Ciprofloxacin was studied in electroconvulsive seizures in mice using the tonic extensor phase as end point and seizure threshold as observational parameter. Its interaction with diclofenac and paracetamol was also studied. It was found that Ciprofloxacin produced a significant epileptogenic effect. This was potentiated by diclofenac but paracetamol had no such effect. Though the exact mechanisms involved in this effect are conjectural, role of GABA inhibitory mechanisms is a possibility.
Shrivastava
M P
MP
Department of Pharmacology, Government Medical College, Nagpur.
Makde
S D
SD
Paranjpe
B D
BD
D000082:Acetaminophen / Q000008:administration & dosage / Q000633:toxicity*; D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage / Q000633:toxicity*; D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000633:toxicity*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000633:toxicity*; D002939:Ciprofloxacin / Q000008:administration & dosage / Q000633:toxicity*; D004008:Diclofenac / Q000008:administration & dosage / Q000633:toxicity*; D004357:Drug Synergism; D005260:Female; D008297:Male; D051379:Mice; D012640:Seizures / Q000139:chemically induced*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D018712:Analgesics, Non-Narcotic; D000890:Anti-Infective Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D004008:Diclofenac; D000082:Acetaminophen; D005680:gamma-Aminobutyric Acid; D002939:Ciprofloxacin