Serum interleukin-6 levels in adult acute myelogenous leukemia: relationship with disease characteristics and outcome.
Serum interleukin-6 (IL-6) levels were measured in 58 adult patients with newly diagnosed acute myelogenous leukemia (AML) using an ELISA method in order to find potential clinical correlations. Detectable average levels were 57 +/- 68 pg/ml and 52 patients (90%) had higher cytokine levels than normal donors. IL-6 levels (115 +/- 102 pg/ml versus 36 +/- 40 pg/ml, p = 0.0001) were higher in patients with fever of apparently non infectious origin, and higher levels were associated with higher percentage of blasts in the peripheral blood (R = 0.29, p = 0.04) and in the bone marrow (R = 0.39, p = 0.003), elevated serum LDH level (R = 0.36, p = 0.01), hyperbilirubinemia (R = 0.36, p = 0.008), elevated serum GGT level (R = 0.46, p = 0.003), and elevated serum GOT (R = 0.36, p = 0.008) and GPT levels (R = 0.44, p = 0.004). Highest IL-6 levels were observed in FAB M1 (86 +/- 112 pg/ml), M3 (73 +/- 69 pg/ml), and M6 (92 +/- 60 pg/ml) AML subtypes. Serum IL-6 levels in AML might be related to both non specific inflammatory reactions and the specific biology of the disease.
Thomas
X
X
Service d'Hématologie, Hôpital Edouard Herriot, Lyon, France.
Hirschauer
C
C
Troncy
J
J
Assouline
D
D
Joly
M O
MO
Fiere
D
D
Archimbaud
E
E
D000208:Acute Disease; D000328:Adult; D000368:Aged; D000410:Alanine Transaminase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D014408:Biomarkers, Tumor / Q000032:analysis; D001772:Blood Cell Count; D002478:Cells, Cultured; D018920:Coculture Techniques; D005260:Female; D005347:Fibroblasts / Q000166:cytology; D018922:HL-60 Cells; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D007770:L-Lactate Dehydrogenase / Q000097:blood; D007951:Leukemia, Myeloid / Q000097:blood* / Q000401:mortality / Q000473:pathology; D008099:Liver / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000097:blood*; D016609:Neoplasms, Second Primary / Q000453:epidemiology; D011379:Prognosis; D011446:Prospective Studies; D014407:Tumor Cells, Cultured; D005723:gamma-Glutamyltransferase / Q000097:blood
D014408:Biomarkers, Tumor; D015850:Interleukin-6; D009363:Neoplasm Proteins; D007770:L-Lactate Dehydrogenase; D005723:gamma-Glutamyltransferase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase