title: Regional performance of carotid endarterectomy. Appropriateness, outcomes, and risk factors for complications.
abstract: OBJECTIVE
  Guided by the findings of randomized controlled trials evaluating carotid endarterectomy (CEA), we examined the appropriateness of CEAs performed in our city and determined the incidences and risk factors for postoperative stroke, death, and cardiac complications.
  
  
  METHODS
  Using health records, we retrospectively reviewed 291 consecutive CEAs performed in our region over 18 months. Based on randomized controlled trial results and standardized remeasurements of angiographic carotid stenoses, indications for CEA were considered appropriate for symptomatic carotid stenoses > or = 70%, uncertain for < 70% symptomatic or > or = 60% asymptomatic stenoses, or inappropriate for < 60% asymptomatic stenoses and for patients with preoperative neurological or medical instability.
  
  
  RESULTS
  We found that 41% of patients (118/291) were asymptomatic. Surgical indications were appropriate in 33% of cases (92/281), uncertain in 49% (138/281), and inappropriate in 18% (51/281). Stroke or death occurred within 30 days postoperatively in 5.2% (9/174) of symptomatic patients and 5.1% (6/117) of asymptomatic patients. At least one cardiac complication (angina, congestive heart failure, dysrhythmia, or myocardial infarction) developed in 8.9% (26/291). Independent preoperative risk factors for stroke or death were histories of angina or congestive heart failure and lack of antiplatelet medication; for cardiac complications, risk factors were age > 75 years and a history of congestive heart failure.
  
  
  CONCLUSIONS
  Almost 1 in 5 patients underwent CEA inappropriately, which was most commonly due to apparent over-estimation of stenosis severity, and half had uncertain indications. Our high complication rate possibly negated any overall surgical benefit in the large group of asymptomatic patients.
authors.affiliation: Department of Surgery, MacKenzie Health Sciences Centre, University of Alberta, Edmonton, Canada.
authors.forename: J H
authors.initials: JH
authors.lastname: Wong
authors.forename: J M
authors.initials: JM
authors.lastname: Findlay
authors.forename: M E
authors.initials: ME
authors.lastname: Suarez-Almazor
mesh_terms: D000368:Aged; D000416:Alberta; D002339:Carotid Arteries / Q000000981:diagnostic imaging / Q000601:surgery*; D002533:Cerebral Angiography; D002561:Cerebrovascular Disorders / Q000209:etiology / Q000401:mortality; D015331:Cohort Studies; D004691:Endarterectomy / Q000009:adverse effects; D005260:Female; D006300:Health Services Misuse; D006801:Humans; D008297:Male; D009026:Mortality; D016032:Randomized Controlled Trials as Topic; D012107:Research Design; D012189:Retrospective Studies; D012307:Risk Factors; D016896:Treatment Outcome; D014463:Ultrasonography