Virologic, immunologic, and clinical follow-up of a couple infected by the human immunodeficiency virus type one, group O.
The pathogenic course (virologic, immunologic, and clinical changes) of infection due to human immunodeficiency virus type one (HIV-1) group O viruses is unknown at present. To address this issue, serial HIV-1 isolates from a married couple (patients A and B) infected with a group O virus were analyzed to determine the temporal association between disease status and alterations in several parameters including plasma viral burden as measured by semiquantitative polymerase chain reaction, changes in CD4+ T cells, presence of neutralizing antibodies, and the ability to induce syncytia on the MT2 cells. For patient A who has been asymptomatic for at least 8 years, both the absence of syncytium-inducing (SI) variants and the presence of autologous and heterologous neutralizing antibodies correlated with a clinically healthier status. In contrast, a switch from NSI to SI variants was observed in patient B in 1990, followed by an expanded in vitro host range, increased viral burden, and a sharp decrease in CD4+ T cells 4 years later. Moreover, plasma obtained from this patient uniformly failed to neutralize both autologous and heterologous viruses. These observations in patient B correlated with a slightly unfavorable clinical status. Based on our preliminary results, it appears that the pathogenic course of infections due to group O viruses is similar to that reported previously for infections due to group M viruses.
Nkengasong
J N
JN
Department of Infection and Immunity, Institute of Tropical Medicine, Antwerp, Belgium.
Fransen
K
K
Willems
B
B
Karita
E
E
Vingerhoets
J
J
Kestens
L
L
Colebunders
R
R
Piot
P
P
van der Groen
G
G
D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology* / Q000503:physiopathology / Q000821:virology; D000328:Adult; D018791:CD4 Lymphocyte Count; D015496:CD4-Positive T-Lymphocytes / Q000821:virology; D002478:Cells, Cultured; D005260:Female; D005500:Follow-Up Studies; D015483:HIV Antibodies / Q000097:blood; D015497:HIV-1 / Q000145:classification* / Q000302:isolation & purification / Q000502:physiology; D006801:Humans; D016130:Immunophenotyping; D018655:Lymphocyte Count; D008297:Male; D016133:Polymerase Chain Reaction; D012747:Sexual Partners; D013601:T-Lymphocytes / Q000276:immunology; D013997:Time Factors; D014779:Virus Replication
D015483:HIV Antibodies