Leprosy resistant to multi-drug-therapy (MDT) successfully treated with ampicillin-sulbactam combination--(a case report).
A 50 year male developed a discoid lesion of leprosy on the face. Inspite of Dapsone 100 mg/day and Rifampicin 600 mgm per day the disease spread to both sides of the face and forehead. It became worse with Prednisolone and Clofazimine. It cleared completely when Sultamicillin was added to the latter. This seems to be the first patient of leprosy to be treated with this combination and reported.
Mehta
V R
VR
L.T.M.M. College, Bombay.
D000667:Ampicillin / Q000627:therapeutic use*; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D018432:Drug Resistance, Multiple; D004359:Drug Therapy, Combination; D006801:Humans; D015440:Leprosy, Lepromatous / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009166:Mycobacterium leprae / Q000187:drug effects* / Q000302:isolation & purification; D010406:Penicillins / Q000627:therapeutic use*; D013407:Sulbactam / Q000627:therapeutic use*
D000900:Anti-Bacterial Agents; D010406:Penicillins; D000667:Ampicillin; D013407:Sulbactam