title: Case report: primary cystic keratinizing squamous cell carcinoma of the liver in a patient with treated nasopharyngeal carcinoma.
abstract: Primary squamous cell carcinoma of the liver is very rare; only 18 cases have been recorded. In the present report we document an additional case who had a unique history of stage III non-keratinizing nasopharyngeal carcinoma treated with a full course of radiotherapy in July 1993. Two small hypoechoic cyst-like lesions in the left hepatic lobe were identified at the same time. In July 1995 the 50-year-old patient reported to be suffering from abdominal fullness and tenderness. A large hypodense tumour was demonstrated in the left hepatic lobe by abdominal echography. The patient was diagnosed as having metastatic carcinoma and received two courses of pre-operative chemotherapy followed by left lobectomy of the liver and resection of adherent tissues on 9 August 1995. Pathological study demonstrated a larger hepatic cystic keratinizing squamous cell carcinoma, which most likely arose from a solitary hepatic cyst. Tumour seedings, probably secondary to tumour rupture, were also revealed on the omentum, peritoneum and diaphragm. However, regional lymph nodes were fee of tumour. Systemic work-up failed to demonstrate evidence of local recurrence of nasopharyngeal carcinoma, metastatic lesion or any second primary tumour site.
authors.affiliation: Department of Pathology, National Taiwan University Hospital, Taipei, Taiwan.
authors.forename: Y Y
authors.initials: YY
authors.lastname: Chou
authors.forename: W J
authors.initials: WJ
authors.lastname: Lee
authors.forename: C T
authors.initials: CT
authors.lastname: Su
authors.forename: H C
authors.initials: HC
authors.lastname: Hsu
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D002277:Carcinoma / Q000473:pathology / Q000532:radiotherapy*; D002294:Carcinoma, Squamous Cell / Q000209:etiology* / Q000556:secondary / Q000601:surgery; D003560:Cysts / Q000150:complications* / Q000473:pathology; D006498:Hepatectomy; D006801:Humans; D008107:Liver Diseases / Q000150:complications* / Q000473:pathology; D008113:Liver Neoplasms / Q000209:etiology* / Q000556:secondary / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D009378:Neoplasms, Multiple Primary; D014057:Tomography, X-Ray Computed
chemical_list: D000970:Antineoplastic Agents