title: [123I]beta-CIT single-photon emission tomography in DOPA-responsive dystonia.
abstract: The radiotracer [123I]beta-CIT is a sensitive marker of dopamine uptake sites that can be used to visualize dopaminergic nerve endings in vivo in the human brain. We report on [123I]beta-CIT single-photon emission computed tomography (SPECT) findings in a patient with DOPA-responsive dystonia (DRD). [123I]beta-CIT SPECT showed a striatal radiotracer uptake in the upper range of normal, indicating intact dopamine transporters and structural integrity of nigrostriatal neurons. This differentiates DRD from clinically similar cases with juvenile-onset parkinsonism with dystonia that have a considerable poorer prognosis. [123I]-beta-CIT SPECT may provide a method equally as useful as fluorodopa positron emission tomography in DRD.
authors.affiliation: Department of Neurology, Universities of Würzburg, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Naumann
authors.forename: W
authors.initials: W
authors.lastname: Pirker
authors.forename: K
authors.initials: K
authors.lastname: Reiners
authors.forename: K
authors.initials: K
authors.lastname: Lange
authors.forename: G
authors.initials: G
authors.lastname: Becker
authors.forename: T
authors.initials: T
authors.lastname: Brücke
mesh_terms: D000328:Adult; D000368:Aged; D001665:Binding Sites; D002531:Cerebellum / Q000000981:diagnostic imaging* / Q000378:metabolism; D003342:Corpus Striatum / Q000000981:diagnostic imaging* / Q000378:metabolism; D003937:Diagnosis, Differential; D004298:Dopamine / Q000378:metabolism; D004421:Dystonia / Q000000981:diagnostic imaging* / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007980:Levodopa / Q000627:therapeutic use*; D008875:Middle Aged; D011849:Radioactive Tracers; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D011849:Radioactive Tracers; D007980:Levodopa; D004298:Dopamine