Overview on human breast cancer with focus on prognostic and predictive factors with special attention on the tumour suppressor gene p53.
A long list of potential prognostic markers has been analysed for breast cancer, some of them will be reviewed in this article. The lymph node status is still the best prognostic marker. The lymph node status combined with information on tumour size, receptor- and proliferation status of the tumour should be analysed as standard for all breast cancer patients. Prognostic information for breast cancer patients has also been described for the membrane protein c-erbB2, the protease cathepsin D, plasminogen activators and inhibitors, certain oncogenes and tumour suppressor genes. Some of these factors also give potential additional information on the response to different oncological therapies, and are better denoted predictive factors. In this overview we shortly describe the above mentioned prognostic factors with major focus on the tumour suppressor gene p53 and its prognostic value and potential predictive value.
Norberg
T
T
Department of Oncology, Univ. of Uppsala, Akademiska sjukhuset, Sweden.
Jansson
T
T
Sjøgren
S
S
Mårtensson
C
C
Andréasson
I
I
Fjällskog
M L
ML
Lindman
H
H
Nordgren
H
H
Lindgren
A
A
Holmberg
L
L
Bergh
J
J
D017209:Apoptosis; D014408:Biomarkers, Tumor; D001943:Breast Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000401:mortality* / Q000473:pathology; D016158:Genes, p53; D006801:Humans; D008207:Lymphatic Metastasis; D011237:Predictive Value of Tests; D011379:Prognosis
D014408:Biomarkers, Tumor