[The effect of ritanserin on the formation and expression of an opiate abstinence syndrome].
The described dependence was formed in mice [correction of rats] by subcutaneous injections of morphine in doses growing from 10 to 100 mg/kg (8 days, twice a day). The effect of 5-HT2 receptor blocker ritanserine (1, 5, and 10 mg/kg) on expression of the abstinence syndrome (according to the behavioral and somato-autonomic parameters) 24 h after morphine discontinuation was studied. Ritanserine attenuated the manifestation of some abstinence parameters associated with activation of the serotonin system in formation of the dependence. The effect was less in expression of abstinence.
Verbitskaia
E V
EV
Kudriashova
M F
MF
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D008297:Male; D051379:Mice; D009020:Morphine / Q000008:administration & dosage / Q000009:adverse effects*; D009021:Morphine Dependence / Q000150:complications* / Q000209:etiology; D011985:Receptors, Serotonin / Q000187:drug effects / Q000502:physiology; D016713:Ritanserin / Q000627:therapeutic use*; D012702:Serotonin Antagonists / Q000627:therapeutic use*; D018709:Statistics, Nonparametric; D013375:Substance Withdrawal Syndrome / Q000188:drug therapy / Q000517:prevention & control*
D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D016713:Ritanserin; D009020:Morphine
Vliianie ritanserina na formirovanie i ékspressiiu opiatnogo abstinentnogo sindroma.