title: Melanoma in children and adolescents.
abstract: Melanoma is a life-threatening and rare malignancy in childhood and adolescence. Because it is so uncommon, melanoma may not be recognized readily or considered seriously in a differential diagnosis, resulting in delays in definitive treatment. We review melanoma occurring in 13 patients under 20 years of age who presented to a single tertiary care children's hospital. Five patients had nonmetastatic primary cutaneous melanoma, with Breslow thickness measurement ranging from 0.84 to 7.8 mm. Three patients had metastatic primary cutaneous melanoma, three had metastatic melanoma arising ina congenital giant nevus, and two had primary leptomeningeal melanoma. All of the patients were given definitive surgical treatment; some received adjunctive radiation therapy and chemotherapy. Overall 5-year survival rate was 40.0% for all cutaneous melanomas, which included 100% for clinical stage I disease, and 0% for clinical stage II and III disease. Both patients with primary leptomeningeal melanoma died an average of 6 months following diagnosis. Nonmetastatic primary cutaneous melanoma is a survivable disease if detected early and treated by surgical excision; metastatic and leptomeningeal disease were uniformly fatal. Types of melanoma, risk factors for melanoma, and the role of the dermatologist in primary prevention and detection are discussed.
authors.affiliation: Division of Dermatology, Ohio State University College of Medicine, Columbus, USA.
authors.forename: S J
authors.initials: SJ
authors.lastname: Wu
authors.forename: D R
authors.initials: DR
authors.lastname: Lambert
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D062109:Dermatologic Surgical Procedures; D003937:Diagnosis, Differential; D004358:Drug Therapy; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008499:Medical Records; D008545:Melanoma / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D009506:Nevus / Q000473:pathology; D012189:Retrospective Studies; D012307:Risk Factors; D012867:Skin / Q000473:pathology*; D012878:Skin Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery