title: [Autoantibodies against nerve tissue proteins long after cranio-cerebral injury].
abstract: 20 samples of serum of patients with remote consequences of brain trauma were tested to detect autoantibodies (a-AB) against brain proteins S-100 and NKP. Essential pathology was not found out by standard solid-phase immunoassay. The original method was used to detect a-AB to the whole complex of antigen determinants. Using this method the elevation of a-AB against S-100 and NKP was shown at 16 cases. The disturbance of idiotype-antiidiotype regulation was revealed at this group of patients. It is suggested that insufficient level of corresponding antiidiotypes creates the conditions for autoimmune aggressor of a-AB against brain tissue.
authors.forename: S G
authors.initials: SG
authors.lastname: Morozov
authors.forename: L M
authors.initials: LM
authors.lastname: Asanova
authors.forename: B B
authors.initials: BB
authors.lastname: Gnedenko
authors.forename: L F
authors.initials: LF
authors.lastname: Panchenko
authors.forename: T N
authors.initials: TN
authors.lastname: Lavrova
mesh_terms: D000328:Adult; D001324:Autoantigens / Q000097:blood*; D001930:Brain Injuries / Q000276:immunology*; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000276:immunology*; D013997:Time Factors
chemical_list: D001324:Autoantigens; D009419:Nerve Tissue Proteins
vernacular_title: Autoantitela k belkam nervnoĭ tkani v otdalennom periode cherepno-mozgovoĭ travmy.