title: [Merkel cell and neuro-cutaneous system].
abstract: The Merkel cell is an epidermal neuroendocrine cell that can be identified by electron microscopy based on its neurosecretory granules or by immunolabeling based on its pattern of cytokeratin expression. Its origin is controversial but may be epidermal rather than neural. Although its functions have not been completely elucidated, there is strong evidence that it produces neuromediators, is involved in the perception of mechanical stimuli, exerts trophic and attractant effects on nerves, stimulates keratinocyte proliferation and differentiation, and plays a role in the spatial organization of the epidermis and epidermal appendages.
authors.affiliation: INSERM U 346, Hôpital Edourd-Herriot, Lyon, France.
authors.forename: L
authors.initials: L
authors.lastname: Misery
authors.forename: A
authors.initials: A
authors.lastname: Gaudillère
mesh_terms: D015266:Carcinoma, Merkel Cell / Q000175:diagnosis; D002455:Cell Division; D006801:Humans; D066298:In Vitro Techniques; D018862:Merkel Cells / Q000378:metabolism / Q000473:pathology / Q000502:physiology* / Q000648:ultrastructure; D009475:Neurons, Afferent / Q000502:physiology*; D018377:Neurotransmitter Agents / Q000378:metabolism; D012867:Skin / Q000166:cytology* / Q000294:innervation*; D012878:Skin Neoplasms / Q000175:diagnosis
chemical_list: D018377:Neurotransmitter Agents
vernacular_title: Cellule de Merkel et système neuro-cutané.