title: Lung injury related to consuming Sauropus androgynus vegetable.
abstract: BACKGROUND
  Taking Sauropus androgynus, a Malaysian food, to reduce weight began as a fad in Taiwan in 1994. Some advocates of this fad developed pulmonary dysfunction. The aim of this study is to report the lung injury in patients taking Sauropus androgynus.
  
  
  METHODS
  From July 1995 to November 1995, we investigated 104 nonsmoking patients (one male and 103 females) with chest roentgenography, pulmonary function, test, and Technetium 99m-labeled diethylene triamine penta-acetate (Tc-99m DTPA) radioaerosol inhalation lung scintigraphy.
  
  
  RESULTS
  Among the 90 patients receiving Tc-99m DTPA inhalation lung scan, 46 (51.1%) patients had increased clearance of Tc-99m DTPA from lung and 20 (22.2%) patients had inhomogeneous deposition of the submicronic radioaerosol. Eighteen (18/100) patients had obstructive ventilatory impairment in pulmonary function test. Analyzing the results, we found that the patients with respiratory symptoms (n = 42) took more vegetables (p = 0.016), had increased clearance of Tc-99m DTPA (p = 0.010) and had lower FEV1 (p = 0.001), FEV1/FVC (p < 0.001), FEF25-75 (p = 0.001), VC (p = 0.002) and DLCO (p = 0.009) than the patients without respiratory symptoms (n = 62). FEV1 and FEV1/FVC were significantly reduced in patients with severe impairment of alveolar permeability. The cumulative dosage and duration of exposure were significantly associated with the reduction of FEV1 and FEV1/FVC.
  
  
  CONCLUSIONS
  The lung injury after taking Sauropus androgynus involves alveoli and/or small airways and is manifest as obstructive ventilatory impairment with inhomogeneous aerosol distribution and increased lung epithelial permeability.
authors.affiliation: Taichung Veterans General Hospital, Taiwan, Republic of China.
authors.forename: C L
authors.initials: CL
authors.lastname: Wu
authors.forename: W H
authors.initials: WH
authors.lastname: Hsu
authors.forename: C D
authors.initials: CD
authors.lastname: Chiang
authors.forename: C H
authors.initials: CH
authors.lastname: Kao
authors.forename: D Z
authors.initials: DZ
authors.lastname: Hung
authors.forename: S L
authors.initials: SL
authors.lastname: King
authors.forename: J F
authors.initials: JF
authors.lastname: Deng
mesh_terms: D000293:Adolescent; D000328:Adult; D000336:Aerosols; D000368:Aged; D002199:Capillary Permeability; D002681:China; D004365:Drugs, Chinese Herbal; D004848:Epithelium / Q000473:pathology; D005260:Female; D006801:Humans; D007553:Isotope Labeling; D008168:Lung / Q000000981:diagnostic imaging / Q000473:pathology* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D010939:Plant Poisoning / Q000473:pathology*; D011650:Pulmonary Alveoli / Q000473:pathology; D012123:Pulmonary Ventilation; D013902:Radiography, Thoracic; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D012129:Respiratory Function Tests; D016284:Technetium Tc 99m Pentetate; D014675:Vegetables / Q000009:adverse effects*
chemical_list: D000336:Aerosols; D004365:Drugs, Chinese Herbal; D019275:Radiopharmaceuticals; D016284:Technetium Tc 99m Pentetate