title: [Stability of vitamins in parenteral nutrition: a comparison of multi-layer and uni-layer bags].
abstract: The goal of this study was to compare vitamin A, E, C, B12, B2 and folic acid concentrations in parenteral nutrition solutions in multilayer and single layer EVA bags. Two different bag trade marks were used: Bexen and Miramed. We measured vitamin concentrations at 24 hours, the fifth and seventh day after refrigerated storage and the eighth day after 24 hours at room temperature. Trace-element and temperature influence were studied. Vitamins A, E, B12, B2 and folic acid had a similar behaviour with multi-layer and one-layer bags. No differences were observed between solutions with and without trace-elements. The concentrations remained within acceptable ranges. We observed a clear decrease of vitamin C, that can be avoided with the use of multilayer bags. These bags can be useful in home parenteral nutrition or when vitamins cannot be added immediately before its administration. An important loss of vitamin A was also detected in parenteral nutrition solutions without lipids, both in multilayer and single layer bags, despite photoprotection and refrigeration.
authors.affiliation: Servicio de Farmacia, Hospital 12 de Octubre, Madrid, España.
authors.forename: P
authors.initials: P
authors.lastname: Gomis Muñoz
authors.forename: S
authors.initials: S
authors.lastname: Miguélez Sánchez
authors.forename: J A
authors.initials: JA
authors.lastname: Navarro Gonzálvez
authors.forename: J
authors.initials: J
authors.lastname: Estenoz Alfaro
authors.forename: E
authors.initials: E
authors.lastname: Alegre del Rey
authors.forename: J M
authors.initials: JM
authors.lastname: Moreno Villares
authors.forename: M A
authors.initials: MA
authors.lastname: Valero Zannuy
authors.forename: M
authors.initials: M
authors.lastname: León Sanz
mesh_terms: D001205:Ascorbic Acid; D004355:Drug Stability; D006801:Humans; D010288:Parenteral Nutrition / Q000295:instrumentation*; D012034:Refrigeration; D012996:Solutions; D013696:Temperature; D013997:Time Factors; D014131:Trace Elements; D014801:Vitamin A; D014815:Vitamins
chemical_list: D012996:Solutions; D014131:Trace Elements; D014815:Vitamins; D014801:Vitamin A; D001205:Ascorbic Acid
vernacular_title: Estabilidad de vitaminas en nutrición parenteral: comparación de bolsas multicapa frente a unicapa.