title: The immunophenotypic characterization of bovine lymphomas.
abstract: A prospective analysis of 38 cases of bovine lymphoma was performed. Thirty-five of the lymphomas were considered enzootic because of serologic or molecular biologic association with the bovine leukemia virus (BLV). The three remaining cases were in cattle < 1 year of age and were not associated with BLV and hence were considered sporadic lymphomas. Utilizing the national cancer Institute Working Formulation for the morphologic classification of human non-Hodgkin's lymphoma, 54.3% (19/35) of the enzootic lymphomas were classified as the diffuse large cleaved cell type. The cells of the 35 enzootic lymphomas expressed a consistent immunophenotype represented by MHCII+, gamma-heavy chain+, and lambda-light chain+; this constellation of markers indicated a mature B-cell phenotype. The three sporadic lymphomas failed to express MHCII antigen despite the presence of other B-cell antigens. There was no correlation between morphologic cell type and immunophenotype in these bovine lymphomas.
authors.affiliation: Department of Pathobiology, University of Guelph, ON, Canada.
authors.forename: W
authors.initials: W
authors.lastname: Vernau
authors.forename: R M
authors.initials: RM
authors.lastname: Jacobs
authors.forename: V E
authors.initials: VE
authors.lastname: Valli
authors.forename: J L
authors.initials: JL
authors.lastname: Heeney
mesh_terms: D000818:Animals; D002417:Cattle; D016583:Enzootic Bovine Leukosis / Q000145:classification / Q000276:immunology* / Q000473:pathology*; D005260:Female; D016130:Immunophenotyping / Q000662:veterinary*; D001909:Leukemia Virus, Bovine; D016393:Lymphoma, B-Cell / Q000145:classification / Q000473:pathology* / Q000662:veterinary*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000473:pathology / Q000662:veterinary; D008228:Lymphoma, Non-Hodgkin / Q000145:classification / Q000473:pathology* / Q000662:veterinary*; D011446:Prospective Studies