GTP gamma S and forskolin-stimulated adenylyl cyclase activity in post-mortem brain from depressed suicides and controls.
We have measured basal, guanosine 5'-O-(3-thiotriphosphate) (GTP gamma S) and forskolin-stimulated adenylyl cyclase activity in samples of frontal and parietal cortex obtained at post-mortem from suicides, with a firm retrospective diagnosis of depression. The suicides were divided into those free of antidepressants and those receiving antidepressants. Each suicide was individually compared to a gender and age-matched control. Although we found no significant differences in adenylyl cyclase activity between controls and either antidepressant-free or antidepressant-treated suicides, there was a trend for lower stimulated adenylyl cyclase activity in suicides.
Lowther
S
S
Department of Pharmacology and Clinical Pharmacology, St George's Hospital Medical School, London, UK. slowther@sghms.ac.uk
Crompton
M R
MR
Katona
C L
CL
Horton
R W
RW
D000262:Adenylyl Cyclases / Q000378:metabolism*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000928:Antidepressive Agents / Q000008:administration & dosage; D001921:Brain / Q000187:drug effects / Q000502:physiology; D002102:Cadaver; D005576:Colforsin / Q000494:pharmacology*; D003863:Depression / Q000188:drug therapy / Q000201:enzymology* / Q000473:pathology; D005260:Female; D016244:Guanosine 5'-O-(3-Thiotriphosphate) / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015398:Signal Transduction / Q000502:physiology; D013405:Suicide
D000928:Antidepressive Agents; D005576:Colforsin; D016244:Guanosine 5'-O-(3-Thiotriphosphate); D000262:Adenylyl Cyclases