title: Further evidence of genetic heterogeneity in hereditary hydronephrosis.
abstract: Hereditary hydronephrosis is a rare condition but several families are described in the literature. The inheritance pattern is autosomal dominant (McKusick number 143400) but the exact aetiology of the hydronephrosis is not clear. However, linkage with the HLA region on chromosome six has been shown previously. We report a family not showing linkage to this region, giving further evidence of genetic heterogeneity in this condition.
authors.affiliation: Yorkshire Regional Genetics Service, St. James Hospital, Leeds, UK.
authors.forename: D
authors.initials: D
authors.lastname: McHale
authors.forename: M E
authors.initials: ME
authors.lastname: Porteous
authors.forename: J
authors.initials: J
authors.lastname: Wentzel
authors.forename: J
authors.initials: J
authors.lastname: Burn
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D005799:Genes, Dominant; D018740:Genetic Heterogeneity; D006801:Humans; D006869:Hydronephrosis / Q000235:genetics*; D007223:Infant; D007231:Infant, Newborn; D008126:Lod Score; D008285:Major Histocompatibility Complex / Q000235:genetics; D008297:Male; D010375:Pedigree; D011995:Recombination, Genetic