title: Helicobacter mustelae-associated gastric adenocarcinoma in ferrets (Mustela putorius furo).
abstract: Helicobacter pylori in humans is associated with active, chronic gastritis, peptic ulcer disease, and most recently has been linked epidemiologically to gastric adenocarcinoma. A related organism, Helicobacter mustelae, naturally infects ferrets and also causes a persistent gastritis, a precancerous lesion, and focal glandular atrophy of the proximal antrum. In this report, we document the clinical presentation and histopathologic confirmation of H. mustelae-associated gastric adenocarcinoma in two middle-aged male ferrets. The ferret appears to be well suited to study the pathogenesis of naturally occurring Helicobacter sp.-induced gastric adenocarcinoma.
authors.affiliation: Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge 02139, USA.
authors.forename: J G
authors.initials: JG
authors.lastname: Fox
authors.forename: C A
authors.initials: CA
authors.lastname: Dangler
authors.forename: W
authors.initials: W
authors.lastname: Sager
authors.forename: R
authors.initials: R
authors.lastname: Borkowski
authors.forename: J M
authors.initials: JM
authors.lastname: Gliatto
mesh_terms: D000230:Adenocarcinoma / Q000382:microbiology / Q000473:pathology* / Q000662:veterinary*; D000818:Animals; D005289:Ferrets; D016998:Helicobacter / Q000302:isolation & purification*; D016481:Helicobacter Infections / Q000473:pathology* / Q000662:veterinary*; D008297:Male; D013274:Stomach Neoplasms / Q000382:microbiology / Q000473:pathology* / Q000662:veterinary*