Mast cells as potent inflammatory cells.
In the last decade, new information was achieved on mast cells (MC). Their origin is assumed to be different from that of the basophils. There are two types of MC with differences in structure, distribution and function: conjunctival and mucosal. MCs are among the most important cells in the development of allergic inflammation through the cytokines and mediators released on the activation of the surface receptors (high-affinity receptors for IgE: Fc epsilon R1). The cytokines released by MCs, e.g., interleukin 5 (IL5), IL8, are chemoattractants for eosinophils and neutrophils, respectively. The two types of mediators released by MC-those preformed, such as histamine, tryptase, serotonin, and the newly-synthetized ones, such as prostaglandin D2 (PGD2), leukotrienes C4 (LTD4), D4 (LTD4), E4 (LTE4), induce vasodilatation, bronchoconstriction, cellular chemotaxis, increase vascular permeability. The involvement of MC in many human diseases was shown within in vivo and in vitro studies (in allergy, lung fibrosis, atherosclerosis, carcinogenesis, etc.).
Dumitraşcu
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Third Medical Department, University of Medicine and Pharmacy, Cluj-Napoca, Romania.
D016207:Cytokines / Q000502:physiology; D006801:Humans; D006967:Hypersensitivity / Q000209:etiology / Q000276:immunology / Q000503:physiopathology; D007249:Inflammation / Q000209:etiology* / Q000276:immunology / Q000503:physiopathology; D018836:Inflammation Mediators / Q000502:physiology; D008407:Mast Cells / Q000166:cytology* / Q000276:immunology / Q000502:physiology; D011956:Receptors, Cell Surface / Q000276:immunology
D016207:Cytokines; D018836:Inflammation Mediators; D011956:Receptors, Cell Surface