Dietary L-arginine supplementation normalizes regional blood flow in Dahl-Iwai salt-sensitive rats.
We performed the present study to determine 1) whether different organs undergo similar increase in vascular resistance in Dahl-Iwai salt-sensitive (S) rats, and 2) the effects of chronic oral L-arginine supplementation on the regional hemodynamics in S rats. Male 6 week old S rats and Dahl-Iwai salt-resistant (R) rats were maintained on an 8% NaCl chow for 4 weeks. One group (S or R rats) was maintained on tap water and the other group (S/Arg) of S rats received tap water containing L-arginine at a concentration of 1.5%. Organ blood flow and cardiac output were measured with microspheres in the conscious condition. Concerning regional hemodynamics, the flow rate of the kidney was lower in S rats than in R rats, but there were no differences between S and R rats in the flow rates of the brain, heart, lung, liver, spleen, intestine, skeletal muscle and skin. The flow rate of the kidney in S/Arg rats was maintained at a higher level as compared to that of S rats. Urinary excretion of protein and albumin in S/Arg rats was significantly suppressed when compared to S rats. Thus, the supplementation of L-arginine normalized the abnormality of renal hemodynamics accompanying salt-induced hypertension. It is suggested that the disturbance in the production of nitric oxide may induce salt-sensitive hypertension and the abnormality of renal hemodynamics in the S rats.
He
H
H
Department of Pharmacology, Kagawa Medical School, Miki-cho, Kita-gun, Japan.
Kimura
S
S
Fujisawa
Y
Y
Tomohiro
A
A
Kiyomoto
K
K
Aki
Y
Y
Abe
Y
Y
D000419:Albuminuria / Q000652:urine; D000818:Animals; D001120:Arginine / Q000008:administration & dosage* / Q000494:pharmacology; D001775:Blood Circulation / Q000187:drug effects*; D006152:Cyclic GMP / Q000652:urine; D004032:Diet; D004351:Drug Resistance / Q000235:genetics; D006439:Hemodynamics / Q000187:drug effects; D006973:Hypertension / Q000139:chemically induced* / Q000235:genetics* / Q000503:physiopathology; D008297:Male; D008863:Microspheres; D011507:Proteinuria / Q000652:urine; D051381:Rats; D011919:Rats, Inbred Strains / Q000235:genetics / Q000502:physiology / Q000652:urine; D012039:Regional Blood Flow / Q000187:drug effects; D012965:Sodium Chloride / Q000494:pharmacology*
D012965:Sodium Chloride; D001120:Arginine; D006152:Cyclic GMP