Effects of mucin ophthalmic solution on epithelial wound healing in rabbit cornea.
To test the hypothesis that a mucin ophthalmic solution could accelerate the healing of corneal epithelium, we conducted a study in rabbits using an ophthalmic solution containing mucin extracted from bovine submaxillary gland. The corneas of rabbits were abraded with a razor blade in the central portion over an area demarcated with a 7-mm trephine. Mucin-containing eye drops were instilled into the right eye 4 times a day for 3 days, and the vehicle was instilled into the left eye. After enucleation, the eyes were observed by scanning and transmission electron microscopy as well as light microscopy. Mucin-containing eye drops were shown to reduce the epithelial defect area more rapidly than the vehicle. Thus, the eye drops accelerated corneal epithelial wound healing.
Shigemitsu
T
T
Department of Ophthalmology, Fujita Health University, School of Medicine, Aichi, Japan.
Shimizu
Y
Y
Majima
Y
Y
D000818:Animals; D002417:Cattle; D003315:Cornea / Q000473:pathology; D065306:Corneal Injuries; D004848:Epithelium / Q000293:injuries / Q000473:pathology; D008297:Male; D008854:Microscopy, Electron; D008855:Microscopy, Electron, Scanning; D009077:Mucins / Q000494:pharmacology*; D009883:Ophthalmic Solutions; D011817:Rabbits; D014945:Wound Healing / Q000187:drug effects*
D009077:Mucins; D009883:Ophthalmic Solutions