Embryonic asymmetry: left TGFbeta at the right time?
Vertebrates have consistent differences between their left and right sides. In all species, nodal, a transforming growth factor beta superfamily signalling protein, is involved in a late step in the pathways that specify such asymmetry in the embryo. Earlier components seem not so well conserved.
King
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Department of Anatomy and Developmental Biology MRC EET Unit St George's Hospital Medical School Cranmer Terrace, London, SW17 ORE, UK.
Brown
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D000818:Animals; D002642:Chick Embryo; D004627:Embryonic Induction; D005314:Embryonic and Fetal Development; D007839:Functional Laterality; D018507:Gene Expression Regulation, Developmental; D008648:Mesoderm / Q000502:physiology; D051379:Mice; D008817:Mice, Mutant Strains; D008954:Models, Biological; D016212:Transforming Growth Factor beta / Q000096:biosynthesis* / Q000502:physiology; D014714:Vertebrates / Q000196:embryology*; D014981:Xenopus / Q000378:metabolism
D016212:Transforming Growth Factor beta