title: Peritumoral subarachnoid hemorrhage in microsurgical transitional interface type meningioma: may the interface play a role?
abstract: The evidence of an intracranial hemorrhage from a meningioma, in comparison with bleeding from different intracranial tumours, is very infrequent. The pathophysiological mechanisms that can explain the possibility of bleeding from meningiomas have not been yet completely clarified. We report a case of a left parasagittal meningotheliomatous meningioma, situated in the premotor cortex, presenting with a peritumoral hemorrhage, at the interface between the meningioma and the brain parenchyma, and strictly confined within the subarachnoid space. A detailed immunohystochemical study of the tumour was performed. The neuroradiological and neurosurgical analysis of the tumour-to-brain interface, served to understand the pathophysiology of this uncommon behaviour. Other possible pathomechanisms explaining bleeding from meningiomas, in the light of the more recent literature are discussed.
authors.affiliation: Department of Human Pathology, University of Messina, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Germanò
authors.forename: F M
authors.initials: FM
authors.lastname: Salpietro
authors.forename: F
authors.initials: F
authors.lastname: Cacciola
authors.forename: C
authors.initials: C
authors.lastname: Alafaci
authors.forename: T
authors.initials: T
authors.lastname: Marafioti
authors.forename: E
authors.initials: E
authors.lastname: Cardia
mesh_terms: D006801:Humans; D008297:Male; D008577:Meningeal Neoplasms / Q000473:pathology*; D008579:Meningioma / Q000473:pathology*; D008866:Microsurgery; D008875:Middle Aged; D013345:Subarachnoid Hemorrhage / Q000150:complications* / Q000473:pathology