title: Towards interbreed IBD fine mapping of the mh locus: double-muscling in the Asturiana de los Valles breed involves the same locus as in the Belgian Blue cattle breed.
abstract: The Spanish "Asturiana" cattle breed is characterized by the segregation of a genetically determined muscular hypertrophy referred to as double-muscling or "culones". We demonstrate by linkage analysis that this muscular hypertrophy involves the mh locus previously shown to cause double-muscling in the Belgian Blue cattle breed, pointing towards locus homogeneity of this trait across both breeds. Moreover, using a twopoint and multipoint maximum likelihood approach, we show that flanking microsatellite markers are in linkage disequilibrium with the mh locus in both breeds albeit with different alleles. Finally, we discuss how allelic homogeneity across breeds might be exploited to achieve efficient genetic fine-mapping of the mh locus.
authors.affiliation: Laboratorio de Genetica, Dpto. de Produccion Animal, Universidad Complutense, 28040 Madrid, Spain.
authors.forename: S
authors.initials: S
authors.lastname: Dunner
authors.forename: C
authors.initials: C
authors.lastname: Charlier
authors.forename: F
authors.initials: F
authors.lastname: Farnir
authors.forename: B
authors.initials: B
authors.lastname: Brouwers
authors.forename: J
authors.initials: J
authors.lastname: Canon
authors.forename: M
authors.initials: M
authors.lastname: Georges
mesh_terms: D000818:Animals; D001530:Belgium; D001947:Breeding; D002417:Cattle / Q000235:genetics*; D002874:Chromosome Mapping; D002875:Chromosomes; D005260:Female; D008040:Genetic Linkage / Q000235:genetics; D005819:Genetic Markers; D006984:Hypertrophy / Q000235:genetics; D015810:Linkage Disequilibrium; D008297:Male; D018895:Microsatellite Repeats; D009132:Muscles / Q000002:abnormalities*; D013030:Spain
chemical_list: D005819:Genetic Markers