title: Werner's syndrome--chromosome analyses of cultured fibroblasts and mitogen-stimulated lymphocytes.
abstract: Two cases of Werner's syndrome are reported. Fibroblasts derived from both patients revealed reduced population doubling numbers. Chromosomal analyses for fibroblasts from both patients and lymphocytes from one patient revealed that chromosomal aberrations occur frequently and randomly. Although some of the chromosomal aberrations involved sites where tumour suppressor genes have been mapped, neither of our patients demonstrated malignancy. Chromosomal aberration at one critical site may not be sufficient to induce cancer or additional factors may be necessary.
authors.affiliation: Department of Dermatology, Faculty of Medicine, Kyoto University, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Morita
authors.forename: C
authors.initials: C
authors.lastname: Nishigori
authors.forename: M S
authors.initials: MS
authors.lastname: Sasaki
authors.forename: N
authors.initials: N
authors.lastname: Matsuyoshi
authors.forename: K
authors.initials: K
authors.lastname: Ohta
authors.forename: H
authors.initials: H
authors.lastname: Okamoto
authors.forename: K
authors.initials: K
authors.lastname: Ikai
authors.forename: S
authors.initials: S
authors.lastname: Imamura
mesh_terms: D018929:Cell Culture Techniques; D002455:Cell Division; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D002869:Chromosome Aberrations; D019066:Facies; D005260:Female; D005347:Fibroblasts / Q000502:physiology; D006801:Humans; D007621:Karyotyping; D008214:Lymphocytes / Q000502:physiology; D008875:Middle Aged; D014898:Werner Syndrome / Q000235:genetics*