title: Generalized epilepsies: emerging insights into cellular and genetic mechanisms.
abstract: In the past year we have gained significant insights into the molecular and genetic mechanisms underlying generalized absence seizures, primarily through the study of animal models. Also a new understanding has emerged about the genetic bases of certain syndromes in which generalized myoclonic and tonic-clonic seizures are expressed. New insights into these different types of generalized seizures may lead eventually to new therapies.
authors.affiliation: Department of Medicine (Neurology), Duke University Medical Center, Durham, USA. dhosford@acpub.duke.edu
authors.forename: D A
authors.initials: DA
authors.lastname: Hosford
authors.forename: S J
authors.initials: SJ
authors.lastname: Caddick
authors.forename: F H
authors.initials: FH
authors.lastname: Lin
mesh_terms: D000818:Animals; D001921:Brain / Q000002:abnormalities / Q000503:physiopathology; D004831:Epilepsies, Myoclonic / Q000235:genetics / Q000503:physiopathology; D004832:Epilepsy, Absence / Q000235:genetics / Q000503:physiopathology; D004829:Epilepsy, Generalized / Q000235:genetics* / Q000503:physiopathology; D004830:Epilepsy, Tonic-Clonic / Q000235:genetics / Q000503:physiopathology; D015870:Gene Expression / Q000502:physiology; D006801:Humans; D051379:Mice; D008967:Molecular Biology; D051381:Rats; D013577:Syndrome