Granulocyte-colony stimulating factor in the treatment of colchicine poisoning.
1. Colchicine is a highly active alkaloid used in the treatment of gouty arthritis and pseudogout. In overdose colchicine inhibits cell division effecting organs with a high rate of cell turn-over, such as the gastrointestinal tract and bone marrow. Early fatality results from cardiovascular collapse and respiratory failure, however pancytopenia and overwhelming septicaemia can occur later. 2. We describe a case of suicidal ingestion of 25-30 mg of colchicine in a previously healthy 43-year-old woman. Initial symptoms were mainly gastrointestinal. By day 5 she had developed severe pancytopenia and early sepsis, which were successfully treated using granulocyte colony stimulating factor (G-CSF) 600 micrograms s.c. 3. In vitro G-CSF is produced by the haematopoietic system. However, G-CSF can now be produced by recombinant DNA cloning technology and thus is available clinically. 4. There is no recognised antidote for colchicine poisoning and treatment is symptomatic. Fab fragments may have a promising future in eliminating colchicine from the body, but are currently not clinically available. In those patients that survive the initial phase of poisoning, G-CSF offers an effective method of treating the pancytopenia and preventing overwhelming septicaemia. Daily monitoring of the patient's haematological status is strongly recommended.
Critchley
J A
JA
Department of Clinical Pharmacology, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong.
Critchley
L A
LA
Yeung
E A
EA
Young
R P
RP
Young
R J
RJ
Chan
T Y
TY
Goh
V K
VK
D000328:Adult; D001792:Blood Platelets / Q000187:drug effects; D003078:Colchicine / Q000506:poisoning*; D005260:Female; D006074:Gout Suppressants / Q000506:poisoning*; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use*; D006801:Humans; D007140:Immunoglobulin Fab Fragments / Q000627:therapeutic use; D007962:Leukocytes / Q000187:drug effects; D010198:Pancytopenia / Q000139:chemically induced / Q000209:etiology; D011041:Poisoning / Q000188:drug therapy*
D006074:Gout Suppressants; D007140:Immunoglobulin Fab Fragments; D016179:Granulocyte Colony-Stimulating Factor; D003078:Colchicine