Unidentified antioxidant defences of human plasma in immobilized patients: a possible relation to basic metabolic rate.
Plasma total peroxyl radical scavenging capacity was studied in terminal patients who were chronically immobilized because of an acute (stroke) or chronic neurodegenerative disease (Alzheimer's disease). A luminometric assay was used to measure total antioxidant capacity (TRAP). The immobilized patients showed significant decrease in TRAP primarily because of a decrease in the concentration of unknown antioxidants. Our results suggest that human plasma may contain unknown antioxidants, the regulation of which could be related to the basic metabolic rate.
Aejmelaeus
R
R
Laboratory of Neurobiology, Medical School, University of Tampere, Finland.
Ketelä
T M
TM
Pirttilä
T
T
Hervonen
A
A
Alho
H
H
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000378:metabolism; D000975:Antioxidants / Q000378:metabolism*; D001205:Ascorbic Acid / Q000097:blood; D001481:Basal Metabolism; D002561:Cerebrovascular Disorders / Q000378:metabolism; D005260:Female; D006801:Humans; D007103:Immobilization; D008875:Middle Aged; D013438:Sulfhydryl Compounds / Q000097:blood; D014527:Uric Acid / Q000097:blood; D014810:Vitamin E / Q000097:blood
D000975:Antioxidants; D013438:Sulfhydryl Compounds; D014810:Vitamin E; D014527:Uric Acid; D001205:Ascorbic Acid