[The interaction of GABA-A receptors with the serotoninergic system of the brain in regulating the testosterone level by the negative feedback mechanism].
A unilateral hemicastration decreased the serotonin and 5-hydroxyindolacetic acid levels in the Wistar rat mediobasal hypothalamus, but not in the midbrain. These neurotransmitters were shown to interact in the process of androgen restoration after the hemicastration. The maximal contribution of GABAergic mechanisms in the testosterone feedback regulation involves the GABA effect via the central GABA-A receptors of the mediobasal hypothalamus' serotoninergic neurons, thus activating the hormone level restoration. The GABA seems to induce a serotonin-independent inhibition of the testosterone level stabilising after hemicastration.
Amikishieva
A V
AV
Kozlova
O N
ON
Serov
L I
LI
Naumenko
E V
EV
D006916:5-Hydroxytryptophan / Q000494:pharmacology; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000502:physiology*; D001923:Brain Chemistry / Q000187:drug effects / Q000502:physiology; D005246:Feedback / Q000187:drug effects / Q000502:physiology*; D018755:GABA Agonists / Q000494:pharmacology; D007033:Hypothalamus, Middle / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008636:Mesencephalon / Q000187:drug effects / Q000378:metabolism; D009118:Muscimol / Q000494:pharmacology; D051381:Rats; D011963:Receptors, GABA-A / Q000187:drug effects / Q000502:physiology*; D011985:Receptors, Serotonin / Q000187:drug effects / Q000502:physiology*; D012701:Serotonin / Q000378:metabolism; D013737:Testis / Q000187:drug effects / Q000502:physiology; D013739:Testosterone / Q000097:blood*
D018755:GABA Agonists; D011963:Receptors, GABA-A; D011985:Receptors, Serotonin; D009118:Muscimol; D012701:Serotonin; D013739:Testosterone; D006916:5-Hydroxytryptophan
Vzaimodeĭstvie GAMK-A retseptorov s serotinergicheskoĭ sistemoĭ golovnogo mozga v reguliatsii urovnia testosterona mekhanizmom otritsatel'noĭ obratnoĭ sviazi.