Thromboxane A2 receptor density increases during chronic exposure to thromboxane A2 receptor antagonists after porcine carotid bypass.
Domestic swine (n=12 in each group) were randomized to daily treatment with the thromboxane A2 (TXA2) receptor antagonist BMS-180291 (group I), aspirin (group II), or no drug (group III) prior to prosthetic carotid graft implantation. Platelet and arterial wall receptor density were measured by equilibrium binding using 125I-BOP. At 6 weeks, means (s.e.m.) platelet receptor density (pmol/mg) had increased in groups I (3.3(0.6) versus 1.8(0.3); P<0.05) and II (2.6(0.6) versus 1.7(0.2); P<0.05), but not in group III (1.3(0.3) versus 1.2(0.2)). Aortic membrane TXA2 receptor density (fmol/mg) was significantly greater (P<0.05) in groups I (150(50)) and II (68(10)) compared with group III (39(6)). Chronic exposure to a TXA2 receptor antagonist or aspirin is associated with increased platelet and aortic receptor density in pigs.
Brothers
T E
TE
Department of Surgery, Medical University of South Carolina and the Ralph Henry Johnson Department of Veterans Affairs Medical Center, Charleston, USA.
Robison
J G
JG
Elliott
B M
BM
Boggs
J M
JM
Halushka
P V
PV
D000818:Animals; D001241:Aspirin / Q000494:pharmacology*; D001807:Blood Vessel Prosthesis; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000494:pharmacology*; D002339:Carotid Arteries / Q000473:pathology / Q000601:surgery; D004305:Dose-Response Relationship, Drug; D005260:Female; D006083:Graft Occlusion, Vascular / Q000473:pathology; D010080:Oxazoles / Q000494:pharmacology*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D011093:Polyethylene Terephthalates; D011138:Polytetrafluoroethylene; D017482:Receptors, Thromboxane / Q000032:analysis / Q000037:antagonists & inhibitors*; D013552:Swine; D017539:Tunica Intima / Q000473:pathology
D019086:Bridged Bicyclo Compounds, Heterocyclic; D010080:Oxazoles; D010975:Platelet Aggregation Inhibitors; D011093:Polyethylene Terephthalates; D017482:Receptors, Thromboxane; D011138:Polytetrafluoroethylene; C078904:ifetroban; D001241:Aspirin