[Comparison between torasemide and furosemide in the treatment of ascites in cirrhotic patients].
Twenty patients with cirrhosis and ascites were randomly divided in two groups to receive 20 mg/die of the new-loop-diuretic torasemide (T), and 50 mg/die of furosemide (F). All patients also received 200 mg/die of potassium canrenoate. Natriuretic and diuretic effects and consequent loss of weight were significantly better in the torasemide-group (T-group). Otherwise, loss of potassium and sodium/potassium ratio in urine were not significantly higher for T-group. Ammonium lowered with T and remained unchanged with F, but the difference was not statistically significant. No change was observed in blood-pressure, pulse-frequency, electrolyte plasmatic levels, azotemia, creatininemia and serum albumin. A significant increase of diuresis was obtained from the fourth day of treatment onwards by replacing F with T in the F-group. The T-group maintained T for eight days just to evaluate its efficacy and tolerability in the middle term: diuresis kept efficient and no side-effects occurred. This trial showed that T was a good and handy drug for cirrhosis with ascites whether as an alternative to F, or as a sequential treatment.
Marelli
A
A
Azienda Ospedaliera, II Divisione Medicina, Instituti Ospedalieri di Cremona.
Bodini
P
P
Reggiani
A
A
Quinzani
M
M
Dizioli
P
P
Tonghini
L
L
D001201:Ascites / Q000188:drug therapy* / Q000209:etiology / Q000652:urine; D004232:Diuretics / Q000627:therapeutic use*; D005260:Female; D005665:Furosemide / Q000627:therapeutic use*; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications* / Q000652:urine; D008297:Male; D008875:Middle Aged; D013449:Sulfonamides / Q000627:therapeutic use*; D000077786:Torsemide
D004232:Diuretics; D013449:Sulfonamides; D005665:Furosemide; D000077786:Torsemide
Confronto tra torasemide e furosemide nella terapia dell'ascite in pazienti cirrotici.