title: Surgery and the tiny baby: sensorineural outcome at 5 years of age. The Victorian Infant Collaborative Study Group.
abstract: OBJECTIVE
  To determine whether an association exists between long-term sensorineural outcome and the need for surgery requiring general anaesthesia during the primary hospitalization in extremely preterm (<27 weeks of gestational age) or extremely low birthweight (ELBW birthweight <100Og) infants.
  
  
  METHODS
  A geographically determined cohort study of extremely preterm or ELBW children in the State of Victoria, Australia. The study subjects were consecutive survivors with either gestational ages <27 weeks or birthweights <10OOg born in the State of Victoria during 3 years from 1 January 1985. The main outcome measure was the rate of sensorineural disability at 5 or more years of age in relation to surgical procedures requiring general anaesthesia performed during the primary hospitalization.
  
  
  RESULTS
  Of 221 children surviving to 5 years of age, 54 (24.4%) had at least one surgical operation requiring general anaesthesia during their primary hospitalization. The operations included the following: (i) ligation of ductus arteriosus (n = 26); (ii) inguinal hernia repair (n = 16); (iii) central nervous system surgery (n = 4); (iv) gastrointestinal surgery (n = 5); and (v) tracheostomy or bronchoscopy (n = 5). Of the 221 survivors to 5 years of age, 218 (98.6%) were assessed for sensorineural impairments and disabilities. Of the 53 children who were assessed at 5 or more years of age and who had had surgery, 7 (13.2%) were severely disabled, 8 (15.1%) were moderately disabled, 12 (22.6%) were mildly disabled,and 26 (49.1%) were non-disabled. The overall rate of sensorineural disability was significantly higher in children who had been operated on compared with those who had not (Mann-Whitney U-test, z =3.7, P<0.001).
  
  
  CONCLUSIONS
  There is an adverse association between the need for surgery requiring general anaesthesia during the primary hospitalization and sensorineural outcome in extremely preterm or ELBW infants.
mesh_terms: D000768:Anesthesia, General / Q000009:adverse effects*; D001766:Blindness / Q000209:etiology; D002547:Cerebral Palsy / Q000209:etiology; D002675:Child, Preschool; D003638:Deafness / Q000209:etiology; D002658:Developmental Disabilities / Q000209:etiology*; D005260:Female; D005500:Follow-Up Studies; D006760:Hospitalization; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000601:surgery*; D019102:Infant, Very Low Birth Weight; D008607:Intellectual Disability / Q000209:etiology; D008297:Male; D012307:Risk Factors; D014739:Victoria