Aeromonas bacteremia in patients with hematologic diseases.
Over a 23-year period, 17 patients with hematologic diseases developed Aeromonas bacteremia while in our hematology ward. Male predominance (14 patients, 82%) was seen, with a predilection for the elderly. Hematologic malignancies, especially acute leukemia, accounted for 15 (88%) of all patients. Cancer chemotherapy and neutropenia (15 patients each) were the most common preceding host conditions. Aeromonas bacteremia generally occurred in the second half of the year (July-December), with no exposure to water or fish. Seven recent isolates comprised Aeromonas sobria (five isolates) and Aeromonas hydrophila (two isolates). Twelve patients (71%) showed a clinical picture ranging from mild gastroenteritis to severe enterocolitis. Anorectal and hepatobiliary infections were also noted in a few patients. The overall mortality rate was 35%. Ten (77%) of the 13 patients who were treated with aminoglycoside plus cephalosporin or carbapenem survived in association with marrow recovery.
Funada
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Protected Environment Unit, Faculty of Medicine, Kanazawa University.
Matsuda
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D000208:Acute Disease; D000328:Adult; D000333:Aeromonas; D000368:Aged; D000741:Anemia, Aplastic / Q000150:complications; D016470:Bacteremia / Q000209:etiology*; D005260:Female; D016905:Gram-Negative Bacterial Infections / Q000209:etiology*; D006801:Humans; D007938:Leukemia / Q000150:complications*; D008228:Lymphoma, Non-Hodgkin / Q000150:complications*; D008297:Male; D008875:Middle Aged