title: Bilateral demyelinating neuropathy in a solitary lytic and sclerotic myeloma of the proximal humerus: a case report.
abstract: Mixed lytic and sclerotic myeloma are uncommon and occur at an earlier age than multiple myeloma in areas of persistent haemopoiesis. Their characteristic symptoms are pain, swelling and pathological fractures and they are usually detected at an early stage. We report a case of a mixed sclerotic/lytic myeloma of the humerus presenting at an unusually advanced stage and associated with a bilateral progressive demyelinating peripheral sensory and motor polyneuropathy resembling polyradiculitis. The neurological changes partly disappeared after the tumour had been resected which suggests that nerve reconstitution may occur due to reversal of the demyelination.
authors.affiliation: Bone Tumour Unit, Royal National Orthopaedic Hospital, London Bone Tumour Service, University of London.
authors.forename: O S
authors.initials: OS
authors.lastname: Schindler
authors.forename: T W
authors.initials: TW
authors.lastname: Briggs
authors.forename: S A
authors.initials: SA
authors.lastname: Gillies
mesh_terms: D001859:Bone Neoplasms / Q000150:complications* / Q000473:pathology / Q000601:surgery; D003711:Demyelinating Diseases / Q000209:etiology*; D005260:Female; D006801:Humans; D006811:Humerus / Q000473:pathology / Q000601:surgery; D008875:Middle Aged; D010954:Plasmacytoma / Q000150:complications* / Q000473:pathology / Q000601:surgery; D019736:Prostheses and Implants