title: Prognostic value of pulmonary hypertension in patients with chronic interstitial lung disease referred for lung or heart-lung transplantation.
abstract: BACKGROUND
  The purpose of this study was to identify precise and reliable prognostic parameters in patients affected by serious chronic interstitial lung disease, who were undergoing screening for lung or heart-lung transplantation.
  
  
  METHODS
  Hemodynamic and respiratory function parameters of 67 patients (43 with idiopathic pulmonary fibrosis, 18 with histiocytosis X, and 6 with lymphangioleiomyomatosis) undergoing clinical screening for lung transplantation.
  
  
  RESULTS
  Statistical analysis showed that hemodynamic and respiratory function parameters in patients affected by histiocytosis X and idiopathic pulmonary fibrosis were not related to survival time. Moreover, the degree of pulmonary hypertension showed no correlation between respiratory function parameters in all the groups of diseases examined. Patients affected with histiocytosis X, even with higher degrees of pulmonary hypertension, had a better survival rate (p < 0.0005) compared with patients with idiopathic pulmonary fibrosis.
  
  
  CONCLUSIONS
  Hemodynamic and respiratory parameters obtained during the clinical screening for lung transplantation do not predict survival and cannot be used as prognostic indicators.
authors.affiliation: Pneumology Department, Niguarda Hospital, Milan, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Harari
authors.forename: G
authors.initials: G
authors.lastname: Simonneau
authors.forename: E
authors.initials: E
authors.lastname: De Juli
authors.forename: F
authors.initials: F
authors.lastname: Brenot
authors.forename: J
authors.initials: J
authors.lastname: Cerrina
authors.forename: P
authors.initials: P
authors.lastname: Colombo
authors.forename: E
authors.initials: E
authors.lastname: Gronda
authors.forename: E
authors.initials: E
authors.lastname: Micallef
authors.forename: F
authors.initials: F
authors.lastname: Parent
authors.forename: P
authors.initials: P
authors.lastname: Dartevelle
mesh_terms: D000328:Adult; D005260:Female; D016027:Heart Transplantation / Q000502:physiology*; D016041:Heart-Lung Transplantation / Q000401:mortality / Q000502:physiology*; D006439:Hemodynamics / Q000502:physiology*; D006646:Histiocytosis, Langerhans-Cell / Q000401:mortality / Q000503:physiopathology / Q000601:surgery; D006801:Humans; D006976:Hypertension, Pulmonary / Q000401:mortality / Q000503:physiopathology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000401:mortality / Q000503:physiopathology*; D011336:Probability; D011379:Prognosis; D011658:Pulmonary Fibrosis / Q000401:mortality / Q000503:physiopathology / Q000601:surgery*; D013147:Spirometry; D015996:Survival Rate