title: [Cerebral apoplexy--anticardiolipin antibody and factor V Leiden mutation].
abstract: A case of a twenty-nine year old woman with ischaemic stroke documented by Magnetic Resonance Imaging scanning is reported. As no embolic source was identified, it was most likely that the ischaemic stroke was caused by in situ arterial thrombosis. Except for a history of cardiovascular disease among her grandparents, she did not exhibit any of the classical risk factors for ischaemic stroke. Therefore, it is of interest that she had high serum concentrations of anticardiolipin antibodies and was a heterozygous carrier of the factor V Leiden mutation. It is possible that the combination of anticardiolipin antibodies and factor V Leiden mutation results in a procoagulant condition of the circulating blood, which in case of minor triggers may cause arterial occlusion. This mechanism may be responsible for the development of ischaemic stroke in the described case.
authors.affiliation: Neuromedicinsk afdeling, Centralsygehuset i Esbjerg.
authors.forename: R
authors.initials: R
authors.lastname: Kirkeby
authors.forename: O D
authors.initials: OD
authors.lastname: Pedersen
mesh_terms: D000328:Adult; D017153:Antibodies, Anticardiolipin / Q000032:analysis*; D002561:Cerebrovascular Disorders / Q000000981:diagnostic imaging* / Q000235:genetics / Q000276:immunology; D005165:Factor V / Q000235:genetics*; D005260:Female; D006801:Humans; D009154:Mutation; D011877:Radionuclide Imaging
chemical_list: D017153:Antibodies, Anticardiolipin; D005165:Factor V
vernacular_title: Apoplexia cerebri--antikardiolipinantistof og faktor V Leiden-mutation.