Glycolic acid peels for postinflammatory hyperpigmentation in black patients. A comparative study.
BACKGROUND
Treatment of postinflammatory hyperpigmentation in patients of Fitzpatrick skin types IV, V, and VI is difficult. Glycolic acid peels are useful for pigment dyschromias in caucasians; however, there are no controlled studies examining their safety and efficacy in dark-complexioned individuals.


OBJECTIVE
To determine if serial glycolic acid peels provide additional improvement when compared with a topical regimen of hydroquinone and tretinoin.


METHODS
Nineteen patients with Fitzpatrick skin type IV, V, or VI were randomized to a control or peel group. The control group applied 2% hydroquinone/10% glycolic acid gel twice daily and 0.05% tretinoin cream at night. The peel patients used the same topical regimen and, in addition, received six serial glycolic acid peels (68% maximum concentration). Patients were evaluated with photography, colorimetry, and subjectively.


RESULTS
Sixteen patients completed the study. Both treatment groups demonstrated improvement, but the patients receiving the glycolic acid peels showed a trend toward more rapid and greater improvement. The peel group also experienced increased lightening of the normal skin.


CONCLUSIONS
This pilot study demonstrates that serial glycolic acid peels provide an additional benefit, with minimal adverse effects, for the treatment of postinflammatory hyperpigmentation in dark-complexioned individuals.
Burns
R L
RL
Department of Dermatology, Henry Ford Hospital, Detroit, Michigan 48202, USA.
Prevost-Blank
P L
PL
Lawry
M A
MA
Lawry
T B
TB
Faria
D T
DT
Fivenson
D P
DP
D000287:Administration, Topical; D000328:Adult; D044383:Black People; D002615:Chemexfoliation; D003872:Dermatitis / Q000150:complications*; D004338:Drug Combinations; D005260:Female; D006016:Glycolates / Q000008:administration & dosage*; D006801:Humans; D006873:Hydroquinones / Q000008:administration & dosage; D017495:Hyperpigmentation / Q000209:etiology / Q000628:therapy*; D007641:Keratolytic Agents / Q000008:administration & dosage; D008875:Middle Aged; D010865:Pilot Projects; D014212:Tretinoin / Q000008:administration & dosage
D004338:Drug Combinations; D006016:Glycolates; D006873:Hydroquinones; D007641:Keratolytic Agents; C031149:glycolic acid; D014212:Tretinoin; C031927:hydroquinone