Increased DNA fragmentation in isolated rat islets following 24 hour co-culture with cytokine transgene-bearing adenovirus is dose dependent, but does not reduce glucose-stimulated insulin secretion.
Weber
M
M
Department of Surgery, Harrison Department of Surgical Research, University of Pennsylvania Medical Center, PA, USA.
Deng
S
S
Kucher
T
T
Shaked
A
A
Ketchum
R J
RJ
Brayman
K L
KL
D000256:Adenoviridae; D000818:Animals; D002478:Cells, Cultured; D018920:Coculture Techniques; D053938:DNA Fragmentation; D015316:Genetic Therapy / Q000379:methods; D005947:Glucose / Q000494:pharmacology*; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000166:cytology* / Q000187:drug effects / Q000502:physiology*; D007763:Lac Operon; D051381:Rats; D011917:Rats, Inbred Lew; D011994:Recombinant Proteins / Q000096:biosynthesis / Q000378:metabolism; D014162:Transfection; D016212:Transforming Growth Factor beta / Q000096:biosynthesis* / Q000378:metabolism; D001616:beta-Galactosidase / Q000096:biosynthesis
D007328:Insulin; D011994:Recombinant Proteins; D016212:Transforming Growth Factor beta; D001616:beta-Galactosidase; D005947:Glucose