title: Sorbitol 2.5% mannitol 0.54% irrigation solution for hysteroscopic endometrial ablation surgery.
abstract: OBJECTIVE
  To determine if systemic absorption of sorbitol 2.5%/mannitol 0.54% irrigation solution (165 mosm.L-1) during hysteroscopic endometrial ablation with diathermy is associated with hyponatraemia and hypoosmolality.
  
  
  METHODS
  In 35 day surgery patients in a university hospital we measured baseline preoperative variables: serum sodium and creatinine concentrations and osmolality, haematocrit, haemoglobin, urine osmolality and sodium concentration, and weight. Fractional excretion of sodium (FENa) was calculated. The same observations were obtained postoperatively before discharge (one hour post resection). Volumes of intraoperative fluid irrigation intravasation and perioperative intravenous fluid absorption (lactated Ringer's solution) were estimated clinically (volumetric).
  
  
  RESULTS
  The mean (+/-SD) serum sodium concentration preoperatively was 140.3 +/- 2.4 mmol.L-1; and postoperatively, 139.7 +/- 2.2 mmol.L-1 (P = NS). The serum osmolality decreased from 285.4 +/- 4.5 to 282.6 +/- 4.1 mmol.kg-1 (P < 0.001). The mean volume of intravasated irrigation fluid was 26.4 ml (range 0-300). During the same time, the FENa increased from 0.57% to 0.79% (P < 0.001).
  
  
  CONCLUSIONS
  In these patients, closely and continuously observed for imbalance between infused and collected irrigation fluid, these was no clinical evidence for hyponatraemic hypoosmolality. However, there was a small 1% +/- 1.5% (mean +/- SD; range -3.4 to 3.6%) decrease in plasma osmolality despite adequate blood volumes as shown by urinary sodium indices.
authors.affiliation: Department of Anesthesia, University of Calgary, AB. moirc@cadvision.com
authors.forename: C L
authors.initials: CL
authors.lastname: Moir
authors.forename: H
authors.initials: H
authors.lastname: Mandin
authors.forename: R
authors.initials: R
authors.lastname: Brant
mesh_terms: D000328:Adult; D000368:Aged; D004717:Endometrium / Q000601:surgery*; D005260:Female; D006801:Humans; D015907:Hysteroscopy; D008353:Mannitol / Q000008:administration & dosage*; D008875:Middle Aged; D009994:Osmolar Concentration; D011446:Prospective Studies; D012964:Sodium / Q000097:blood; D013012:Sorbitol / Q000008:administration & dosage*; D007507:Therapeutic Irrigation
chemical_list: D008353:Mannitol; D013012:Sorbitol; D012964:Sodium