title: A case of malignant lymphoma with hemophagocytic syndrome presenting as hepatic failure.
abstract: We report the case of a 50-year-old female with malignant lymphoma presenting hemophagocytic syndrome and liver failure. She developed high fever, marked jaundice, and progressive liver failure, followed by evidence of disseminated intravascular coagulation (DIC). The course was complicated by severe hepatitis and the patient died six days after admission. Pathological diagnosis on autopsy specimens of the lung hilar lymph nodes was non-Hodgkin's T cell lymphoma, of the diffuse small cell type. Histopathologic examination of the liver demonstrated diffuse liver cell destruction with prominent T lymphocyte infiltration in the portal and periportal area. In addition to marked lymphoma cell infiltration, hemophagocytosis by prominent infiltrative macrophages was observed in various organs, such as the liver and bone marrow, indicating the hemophagocytic syndrome. The hemophagocytic syndrome characterized in the present case may have been responsible for the extremely rapid and fulminant course.
authors.affiliation: Department of Medicine, Kurume University School of Medicine, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Hino
authors.forename: M
authors.initials: M
authors.lastname: Sata
authors.forename: N
authors.initials: N
authors.lastname: Arima
authors.forename: R
authors.initials: R
authors.lastname: Nouno
authors.forename: R
authors.initials: R
authors.lastname: Kumashiro
authors.forename: Y
authors.initials: Y
authors.lastname: Koga
authors.forename: Y
authors.initials: Y
authors.lastname: Uchimura
authors.forename: M
authors.initials: M
authors.lastname: Yoshitake
authors.forename: S
authors.initials: S
authors.lastname: Sakisaka
authors.forename: M
authors.initials: M
authors.lastname: Kojiro
authors.forename: K
authors.initials: K
authors.lastname: Tanikawa
mesh_terms: D017809:Fatal Outcome; D005260:Female; D015616:Histiocytosis, Non-Langerhans-Cell / Q000150:complications / Q000175:diagnosis*; D006801:Humans; D017093:Liver Failure / Q000209:etiology*; D016399:Lymphoma, T-Cell / Q000150:complications / Q000175:diagnosis*; D008875:Middle Aged