title: Bone mineral analysis in patients with biliary atresia after successful Kasai procedure.
abstract: Metabolism is probably disturbed in patients with abnormal liver function who have undergone a successful Kasai procedure. We examined bone mineral metabolism in patients who have successfully undergone Kasai procedure. Bone mineral metabolism was examined in 8 patients with biliary atresia after a successful Kasai procedure. Five patients were female and 3 were male. The ages at Kasai procedure ranged from 50 to 80 days, and the follow-up periods ranged from 3 to 27 years after the operation. All patients eat a normal oral diet. We examined plasma levels of 25-OH-D3, 1, 25-(OH)2-D3, Ca and phosphorus (P). Bone mineral content of the lumbar spine (L2-L4) was assessed by dual energy x-ray absorptiometry (DEXA), and the data were expressed as a bone mineral density (BMD). Two patients showed abnormal levels on hepatic function tests. Plasma levels of 1, 25-(OH)2-D3, Ca, and P were normal in all patients. The level of 25-OH-D3 was normal in 7 patients. BMD levels were normal in 6 patients, but low in 2 who had undergone partial splenic embolization and splenectomy, respectively, due to hypersplenism. In long-term survivors of Kasai procedure, measurement of BMD may detect bone mineral deficiency earlier than measurements of serum levels of 25-OH-D, 1, 25-(OH)2-D, Ca and P.
authors.affiliation: Department of Pediatric Surgery, Kagawa Medical University, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Toki
authors.forename: T
authors.initials: T
authors.lastname: Todani
authors.forename: Y
authors.initials: Y
authors.lastname: Watanabe
authors.forename: Y
authors.initials: Y
authors.lastname: Sato
authors.forename: K
authors.initials: K
authors.lastname: Ogura
authors.forename: M
authors.initials: M
authors.lastname: Yoshikawa
authors.forename: S
authors.initials: S
authors.lastname: Yamamoto
authors.forename: Z Q
authors.initials: ZQ
authors.lastname: Wang
mesh_terms: D015650:24,25-Dihydroxyvitamin D 3 / Q000378:metabolism; D015502:Absorptiometry, Photon; D000293:Adolescent; D000328:Adult; D001656:Biliary Atresia / Q000378:metabolism* / Q000601:surgery*; D001827:Body Height / Q000502:physiology; D001835:Body Weight / Q000502:physiology; D015519:Bone Density / Q000502:physiology*; D002118:Calcium / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D008111:Liver Function Tests; D008297:Male; D011171:Portoenterostomy, Hepatic
chemical_list: D015650:24,25-Dihydroxyvitamin D 3; D002118:Calcium