A human homolog of the vaccinia virus HindIII K4L gene is a member of the phospholipase D superfamily.
We have identified a human gene encoding a protein with 48% amino acid identity to the vaccinia virus (VV) K4L gene product. Both contain motifs characteristic of the phospholipase D (PLD) protein superfamily. These proteins are also related to vaccinia virus p37, encoded by the F13L gene, which is required for envelopment and spread of the virus. The similarity to phospholipase D provides insight into the mechanisms and evolution of these processes.
Cao
J X
JX
Department of Biochemistry and Microbiology, University of Victoria, British Columbia, Canada.
Koop
B F
BF
Upton
C
C
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D018076:DNA, Complementary; D015247:Deoxyribonuclease HindIII; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics; D008969:Molecular Sequence Data; D016366:Open Reading Frames; D010739:Phospholipase D / Q000235:genetics*; D017386:Sequence Homology, Amino Acid; D014616:Vaccinia virus / Q000235:genetics*; D014759:Viral Envelope Proteins / Q000235:genetics*
D018076:DNA, Complementary; D008565:Membrane Proteins; D014759:Viral Envelope Proteins; C084759:p37 protein, Vaccinia virus; D015247:Deoxyribonuclease HindIII; D010739:Phospholipase D