Preliminary evidence for a role of apolipoprotein E alleles in identifying haemodialysis patients at high vascular risk.
Conventional risk factors have very low predictive power in identifying haemodialysis patients at high risk of vascular accidents. A role for apolipoprotein E isotypes was looked for in a small, but rigorously defined, cohort of longterm haemodialysis patients. In individuals with high vascular risk, as identified by higher common carotid intima/media thickness, we found an excess of apolipoprotein E4 alleles. This preliminary result requires confirmation in large patient cohorts.
Olmer
M
M
Nephrology-Dialysis Department, Hôpital de la Conception, Marseille, France.
Renucci
J E
JE
Planells
R
R
Bouchouareb
D
D
Purgus
R
R
D000328:Adult; D000368:Aged; D000483:Alleles; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics* / Q000502:physiology; D001161:Arteriosclerosis / Q000209:etiology / Q000235:genetics / Q000473:pathology; D017536:Carotid Artery, Common / Q000000981:diagnostic imaging / Q000473:pathology; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis / Q000009:adverse effects*; D012307:Risk Factors; D014463:Ultrasonography; D014652:Vascular Diseases / Q000209:etiology* / Q000235:genetics* / Q000473:pathology
D053327:Apolipoprotein E4; D001057:Apolipoproteins E; D008055:Lipids