[Macroprolactinemia, a variety of hyperprolactinemia. Apropos of 5 cases].
Macroprolactinemia, due to increased circulating levels of large molecular weight forms of prolactin, results in elevated level of immuno-reactive prolactin. The big variants have only weak biological activity; thus macroprolactinemia appears as a case of hyperprolactinemia without clinical significance as demonstrated by the five patients described. The diagnosis is based upon chromatography which separates the hormone and its variants. This disorder produces a pitfall in the diagnostic evaluation of hyperprolactinemia.
Recchi
V
V
Service d'endocrinologie, hôpital Pasteur, CHU, Nice, France.
Hieronimus
S
S
Creisson
G
G
Freychet
P
P
Morange
I
I
Canivet
B
B
D000328:Adult; D002648:Child; D002845:Chromatography; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D006966:Hyperprolactinemia / Q000097:blood / Q000145:classification* / Q000175:diagnosis; D008875:Middle Aged; D008970:Molecular Weight; D011388:Prolactin / Q000737:chemistry*
D011388:Prolactin
Macroprolactinémie, une variété d'hyperprolactinémie. A propos de cinq observations.