title: Environmental factors, reproductive history, and selective fertility in farmers' sibships.
abstract: In a national study of births to farmers in Norway, grain farming was associated with short gestational age (21-24 weeks). An impact of selective fertility and maternal heterogeneity on the association was suspected but could not be assessed further in a traditional birth-based design. Thus, analyses based on the mother as the observational unit were performed. A total of 45,969 farmers with a first birth in 1967-1981 were followed for subsequent births and perinatal mortality. A perinatal loss increased farmers' likelihood to continue to another pregnancy, but this selective fertility was less dominant than in the general population due to a higher baseline fertility. The effect of the mother's reproductive history on the grain farming-midpregnancy delivery association was analyzed in 59,338 farmers with more than one single birth in 1967-1991. A history of preterm birth (< 37 weeks) in previous or subsequent pregnancies both was an independent determinant of midpregnancy delivery and also increased the effect of grain exposure. Nongrain farmers with a history of only term births had 1.3 midpregnancy deliveries per 1,000 births; grain farmers with a history of only term births had 1.8 cases per 1,000 (odds ratio (OR) 1.4, 95% confidence interval (CI) 1.0-1.9); nongrain farmers with a history of preterm birth had 6.8 cases per 1,000 (OR 5.5, 95% CI 4.0-7.6), whereas grain farmers with a history of preterm birth had 13.7 cases per 1,000 (OR 11.0, 95% CI 7.7-15.9). Selective fertility had only a marginal impact on the association. The study demonstrates that a maternally based design can contribute in the assessment of joint effects of environmental and maternal factors.
authors.affiliation: National Institute of Occupational Health, Oslo, Norway.
authors.forename: P
authors.initials: P
authors.lastname: Kristensen
authors.forename: L M
authors.initials: LM
authors.lastname: Irgens
authors.forename: T
authors.initials: T
authors.lastname: Bjerkedal
mesh_terms: D000383:Agriculture; D003430:Cross-Sectional Studies; D002523:Edible Grain; D004781:Environmental Exposure; D005260:Female; D005298:Fertility; D006801:Humans; D008137:Longitudinal Studies; D009664:Norway; D011247:Pregnancy; D011256:Pregnancy Outcome; D018873:Pregnancy Rate; D012098:Reproduction