title: Family history of autoimmune diseases in psychosis.
abstract: The mothers of 101 psychotic patients and 116 normal controls were interviewed using a semi-structured questionnaire designed to determine the presence or absence of autoimmune disorders in first degree relatives of the probands. Thyrotoxicosis and insulin-dependent diabetes mellitus were significantly more common in the relatives of the psychotic patients than in the control relatives; in particular thyrotoxicosis was more frequent in the mothers of patients (11%) than the mothers of controls (2.6%). None of the examined characteristics of the patients, including RDC-diagnosis, family history of psychosis, age at onset of psychosis and winter birth, was predictive of thyrotoxicosis and insulin-dependent diabetes mellitus in relatives.
authors.affiliation: Department of Psychological Medicine, Institute of Psychiatry, London, UK.
authors.forename: C M
authors.initials: CM
authors.lastname: Gilvarry
authors.forename: P C
authors.initials: PC
authors.lastname: Sham
authors.forename: P B
authors.initials: PB
authors.lastname: Jones
authors.forename: M
authors.initials: M
authors.lastname: Cannon
authors.forename: P
authors.initials: P
authors.lastname: Wright
authors.forename: S W
authors.initials: SW
authors.lastname: Lewis
authors.forename: P
authors.initials: P
authors.lastname: Bebbington
authors.forename: B K
authors.initials: BK
authors.lastname: Toone
authors.forename: R M
authors.initials: RM
authors.lastname: Murray
mesh_terms: D000293:Adolescent; D000328:Adult; D001327:Autoimmune Diseases / Q000453:epidemiology*; D003922:Diabetes Mellitus, Type 1 / Q000453:epidemiology; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D011618:Psychotic Disorders / Q000175:diagnosis*; D012559:Schizophrenia / Q000175:diagnosis*; D012565:Schizophrenic Psychology; D013971:Thyrotoxicosis / Q000453:epidemiology