Intracerebroventricular injection of mammalian and chicken glucagon-like peptide-1 inhibits food intake of the neonatal chick.
Glucagon-like peptide-1 (GLP-1), structurally similar to glucagon, is synthesized from a larger precursor, preproglucagon, and has been postulated to be a novel incretin. Recently, it was reported that central administration of GLP-1 decreased food intake in rats. The amino acid sequences of GLP-1 are identical in all mammals, and chicken GLP-1 exhibits a high homology with mammalian GLP-1. The aim of this study was to elucidate whether central injection of mammalian or chicken GLP-1 inhibits food intake in the chick, and to compare their effects. Intracerebroventricular administration of mammalian and chicken GLP-1 strongly inhibited food intake of chicks. However, the suppressive effect of both GLP-1 on food intake was similar. These results show that GLP-1 with a variety of amino acid sequences may be the most potent inhibitor of food intake in the chicken.
Furuse
M
M
Laboratory of Animal Nutrition, School of Agricultural Sciences, Nagoya University, Japan. j46117a@nucc.cc.nagoya-u.ac.jp
Matsumoto
M
M
Okumura
J
J
Sugahara
K
K
Hasegawa
S
S
D000595:Amino Acid Sequence; D000704:Analysis of Variance; D000818:Animals; D000831:Animals, Newborn; D002645:Chickens / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D005247:Feeding Behavior / Q000502:physiology*; D005260:Female; D005934:Glucagon / Q000276:immunology*; D052216:Glucagon-Like Peptide 1; D007276:Injections, Intraventricular; D008297:Male; D008322:Mammals / Q000378:metabolism*; D008969:Molecular Sequence Data; D010455:Peptides / Q000032:analysis*; D017386:Sequence Homology, Amino Acid; D013045:Species Specificity
D010455:Peptides; D052216:Glucagon-Like Peptide 1; D005934:Glucagon