Effects of Poncirus trifoliata on type I hypersensitivity reaction.
A study was carried out to examine the effect of an aqueous extract from immature fruit of Poncirus trifoliata L. (Rutaceae) (PTIFE) on the type I hypersensitivity reaction. Forty-eight hour PCA (passive cutaneous anaphylaxis) in rats was significantly inhibited by the oral administration of PTIFE (200 mg/kg). It also inhibited histamine release from rat peritoneal mast cells (RPMC) induced by mouse anti-dinitrophenyl (DNP)-IgE and dinitrophenyl-human serum albumin (DNP-HSA). These results suggest that PTIFE has anti-allergic action against the type I hypersensitivity reaction.
Lee
Y M
YM
Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University, Iksan, Chonbuk, Republic of Korea.
Kim
C Y
CY
Kim
Y C
YC
Kim
H M
HM
D000284:Administration, Oral; D000818:Animals; D000906:Antibodies / Q000008:administration & dosage; D000941:Antigens / Q000276:immunology / Q000633:toxicity; D004140:Dinitrophenols / Q000633:toxicity; D004195:Disease Models, Animal; D005638:Fruit / Q000737:chemistry; D005659:Fungicides, Industrial / Q000633:toxicity; D006636:Histamine Release / Q000187:drug effects; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000188:drug therapy*; D007073:Immunoglobulin E / Q000276:immunology; D007271:Injections, Intradermal; D008297:Male; D008407:Mast Cells / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D010323:Passive Cutaneous Anaphylaxis / Q000187:drug effects*; D010537:Peritoneum / Q000166:cytology / Q000187:drug effects; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012709:Serum Albumin / Q000276:immunology; D013047:Specific Pathogen-Free Organisms
D000906:Antibodies; D000941:Antigens; D004140:Dinitrophenols; D005659:Fungicides, Industrial; D010936:Plant Extracts; D012709:Serum Albumin; D007073:Immunoglobulin E