title: The cytoprotective effect of iloprost against carbon tetrachloride induced necrosis in rat liver.
abstract: The aim of this study was to investigate the cytoprotective effect of Iloprost on the liver against carbon tetrachloride induced necrosis. The serum histamine-like activity was found to be increased when compared with that of controls after treatment with carbon tetrachloride for 18 weeks while prostaglandin E2- and leukotriene C4-like activities were unchanged. After pretreatment with Iloprost for 18 weeks the increased activity of histamine was found to be unchanged while prostaglandin E2-like activity was increased. It is concluded that Iloprost protects the liver against carbon tetrachloride-induced damage and reduces the level of histamine that has a role in the pathogenesis of portal hypertension.
authors.affiliation: Department of General Surgery, Faculty of Medicine, Gazi University, Ankara, Turkey.
authors.forename: S
authors.initials: S
authors.lastname: Bozkurt
authors.forename: E
authors.initials: E
authors.lastname: Ersoy
authors.forename: H E
authors.initials: HE
authors.lastname: Tekýn
authors.forename: O
authors.initials: O
authors.lastname: Bayram
authors.forename: Z
authors.initials: Z
authors.lastname: Anadol
authors.forename: E
authors.initials: E
authors.lastname: Onuk
authors.forename: Z S
authors.initials: ZS
authors.lastname: Ercan
mesh_terms: D000818:Animals; D002251:Carbon Tetrachloride / Q000008:administration & dosage / Q000633:toxicity*; D015232:Dinoprostone / Q000097:blood; D004195:Disease Models, Animal; D005260:Female; D006632:Histamine / Q000097:blood; D006975:Hypertension, Portal / Q000188:drug therapy / Q000517:prevention & control; D016285:Iloprost / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D007279:Injections, Subcutaneous; D017997:Leukotriene C4 / Q000097:blood; D008099:Liver / Q000166:cytology / Q000187:drug effects / Q000473:pathology; D008106:Liver Cirrhosis, Experimental / Q000139:chemically induced / Q000188:drug therapy* / Q000517:prevention & control; D008297:Male; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D010975:Platelet Aggregation Inhibitors; D014665:Vasodilator Agents; D017997:Leukotriene C4; D006632:Histamine; D002251:Carbon Tetrachloride; D016285:Iloprost; D015232:Dinoprostone