Gradients of HLA diversity in South American Indians.
Information concerning the HLA-A and -B loci was considered in relation to 3796 Amerindians living in 39 places in South America, data related to HLA-C being based on a smaller subset of 2989 persons distributed among 33 localities. Synthetic gene frequency maps were then constructed using principal-components analysis. Clearly significant longitudinal (principal component 1) and latitudinal (principal components 1, 2, and 3) clines were observed, most probably indicating ancient migration routes.
Rothhammer
F
F
School of Medicine, University of Chile, Santiago, Chile.
Silva
C
C
Callegari-Jacques
S M
SM
Llop
E
E
Salzano
F M
FM
D000483:Alleles; D000704:Analysis of Variance; D005787:Gene Frequency / Q000235:genetics; D014644:Genetic Variation; D006680:HLA Antigens / Q000235:genetics*; D015234:HLA-A Antigens / Q000235:genetics; D015235:HLA-B Antigens / Q000235:genetics; D015236:HLA-C Antigens / Q000235:genetics; D006801:Humans; D007199:Indians, South American / Q000235:genetics*
D006680:HLA Antigens; D015234:HLA-A Antigens; D015235:HLA-B Antigens; D015236:HLA-C Antigens