Trovafloxacin in treatment of rabbits with experimental meningitis caused by high-level penicillin-resistant Streptococcus pneumoniae.
The fluoroquinolone trovafloxacin was bactericidal (0.47 +/- 0.23 delta log10 CFU/ml x h after 10 mg/kg of body weight and 0.78 +/- 0.15 delta log10 CFU/ml x h after 30 mg/kg) in the treatment of experimental meningitis caused by a highly penicillin-resistant (MIC and minimum bactericidal concentration = 4 and 4 microg/ml) strain of Streptococcus pneumoniae. Combinations with ampicillin and rifampin were indifferent compared to single drugs.
Kim
Y S
YS
San Francisco General Hospital, Department of Medicine, University of California, 94143-0811, USA.
Liu
Q
Q
Chow
L L
LL
Täuber
M G
MG
D000667:Ampicillin / Q000134:cerebrospinal fluid / Q000627:therapeutic use; D000818:Animals; D000900:Anti-Bacterial Agents / Q000134:cerebrospinal fluid / Q000627:therapeutic use; D000890:Anti-Infective Agents / Q000097:blood / Q000134:cerebrospinal fluid / Q000627:therapeutic use*; D002443:Ceftriaxone / Q000134:cerebrospinal fluid / Q000627:therapeutic use; D024841:Fluoroquinolones; D008586:Meningitis, Pneumococcal / Q000188:drug therapy*; D008826:Microbial Sensitivity Tests; D009287:Naphthyridines / Q000097:blood / Q000134:cerebrospinal fluid / Q000627:therapeutic use*; D010403:Penicillin Resistance; D011817:Rabbits; D012293:Rifampin / Q000134:cerebrospinal fluid / Q000627:therapeutic use; D013296:Streptococcus pneumoniae / Q000187:drug effects
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D009287:Naphthyridines; D002443:Ceftriaxone; D000667:Ampicillin; C080163:trovafloxacin; D012293:Rifampin