[Distal gangrene and cryoglobulinemia related to hepatitis C virus infection with presence of anticardiolipin antibodies].
We report the case of a 63-year old women with toe gangrene, peripheral polyneuropathy, polyarthritis, histologically proven necrotizing vasculitis, in association with type III mixed cryoglobulinemia and hepatitis C virus (HCV) infection. Raised anticardiolipin antibodies (aCL) were found, without beta 2-glycoprotein I. HCV infection is associated with mixed cryoglobulinemia which can cause a vasculitis affecting various organs. The pathogenesis of production and clinical significance of aCL could be associated in this case with HCV infection.
Jacq
F
F
Service de médecine interne, hôpital Broussais, Paris, France.
Emmerich
J
J
Héron
E
E
Lortholary
O
O
Bruneval
P
P
Fiessinger
J N
JN
D017153:Antibodies, Anticardiolipin / Q000032:analysis*; D003449:Cryoglobulinemia / Q000209:etiology* / Q000628:therapy; D005260:Female; D005734:Gangrene; D006526:Hepatitis C / Q000150:complications* / Q000276:immunology / Q000628:therapy; D006801:Humans; D008875:Middle Aged; D014034:Toes / Q000473:pathology*; D014657:Vasculitis / Q000209:etiology / Q000628:therapy
D017153:Antibodies, Anticardiolipin
Gangrène distale et cryoglobulinémie liée à l'infection par le virus de l'hépatite C avec présence d'anticorps anticardiolipines.