Synthetic trehalose dicorynomycolate (S-TDCM): behavioral effects and radioprotection.
This study evaluated synthetic trehalose dicorynomycolate (S-TDCM), an immunomodulator, for its survival enhancing capacity and behavioral toxicity in B6D2F1 female mice. In survival experiments, mice were administered S-TDCM (25-400 micrograms/mouse i.p.) 20-24 hr before 5.6 Gy mixed-field fission-neutron irradiation (n) and gamma-photon irradiation. The 30-day survival rates for mice treated with 100-400 micrograms/mouse S-TDCM were significantly enhanced compared to controls. Toxicity of S-TDCM was measured in nonirradiated mice by locomotor activity, food intake, water consumption, and alterations in body weight. A dose-dependent decrease was noted in all behavioral measures in mice treated with S-TDCM. Doses of 100 and 200 micrograms/mouse S-TDCM significantly reduced motor activity beginning 12 hr postinjection with recovery by 24 hr. A dose of 400 micrograms/mouse significantly decreased activity within the first 4 hr after administration and returned to control levels by 32 hr following injection. Food and water intake were significantly depressed at doses of 200 and 400 micrograms/mouse on the day following drug administration, and were recovered in 24 hr. Body weight was significantly decreased in the 200 micrograms/mouse group for 2 days and in the 400 micrograms/mouse group for 4 days following injection. A dose of 100 micrograms/mouse effectively enhanced survival after fission-neutron irradiation with no adverse effect on food consumption, water intake, or body weight and a minimal, short-term effect on locomotor activity.
Landauer
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MR
Armed Forces Radiobiology Research Institute, Bethesda, MD 20889-5603, USA. landauer@vax.afrri.usuhs.mil
McChesney
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DG
Ledney
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GD
D000276:Adjuvants, Immunologic / Q000494:pharmacology* / Q000633:toxicity; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects* / Q000528:radiation effects*; D003311:Cord Factors / Q000494:pharmacology* / Q000633:toxicity; D004326:Drinking / Q000187:drug effects / Q000528:radiation effects; D004435:Eating / Q000187:drug effects / Q000528:radiation effects; D005260:Female; D051379:Mice; D009043:Motor Activity / Q000187:drug effects / Q000528:radiation effects; D011837:Radiation-Protective Agents / Q000494:pharmacology* / Q000633:toxicity
D000276:Adjuvants, Immunologic; D003311:Cord Factors; D011837:Radiation-Protective Agents; C043399:6,6'-dicorynomycolyl trehalose