title: High-yield platelet concentrates attainable by continuous quality improvement reduce platelet transfusion cost and donor exposure.
abstract: BACKGROUND
  Donor exposure risk and cost in platelet transfusion practice can be limited by increasing the recovery of platelets from donor units.
  
  
  METHODS
  This study presents results of continuous quality improvement efforts in platelet production and compares the in vivo therapeutic efficacy of currently produced platelet concentrates (PCs) with that of apheresis platelets. Production quality improvement measures included optimization of instrument performance (rotor speed trials), process (massaging whole-blood units, using cup liners, limiting spin-expression time, and refining plasma expression technique), and staff (intensive training with observation and ongoing quality control data feedback). Corrected count increments and increments per kg were calculated for transfusions of 4 pooled PCs and apheresis platelets over a 30-day period.
  
  
  RESULTS
  The mean number of platelets per PC increased from 5.5 x 10(10) in 1975 to 9.69 x 10(10) in 1994. The mean platelet dose was 3.78 x 10(11) for 4 PCs and 4.17 x 10(11) for apheresis platelets. A total of 34 pooled PCs and 17 apheresis platelets was transfused to 21 patients. The mean increment, the increment per kg, and the corrected count increment were, respectively, 31 x 10(3) per microL, 4.8 x 10(2) per microL, and 14,700 for 4 PCs and 35.4 x 10(3) per microL, 5.4 x 10(2) per microL, and 14,700 for apheresis platelets. Differences were not significant.
  
  
  CONCLUSIONS
  Therapeutic efficacy comparable to that of apheresis platelets can be obtained with 4 high-yield PCs.
authors.affiliation: Department of Pathology, Ohio State University Medical Center, American Red Cross Blood Services, Central Ohio Region, USA.
authors.forename: D L
authors.initials: DL
authors.lastname: Kelley
authors.forename: R L
authors.initials: RL
authors.lastname: Fegan
authors.forename: A T
authors.initials: AT
authors.lastname: Ng
authors.forename: M K
authors.initials: MK
authors.lastname: Kennedy
authors.forename: E
authors.initials: E
authors.lastname: Blanda
authors.forename: L A
authors.initials: LA
authors.lastname: Chambers
authors.forename: M S
authors.initials: MS
authors.lastname: Kennedy
authors.forename: L C
authors.initials: LC
authors.lastname: Lasky
mesh_terms: D001782:Blood Donors; D003365:Costs and Cost Analysis; D006801:Humans; D017713:Platelet Transfusion / Q000009:adverse effects* / Q000191:economics*; D012307:Risk Factors; D013997:Time Factors