Reflections on telomeres, growth, aging, and essential hypertension.
Here we review the "telomere hypothesis of cellular aging." We propose that this hypothesis is relevant to our understanding of the roles of genetics as well as growth and development in the etiology of essential hypertension and its cardiovascular complications. Elements of this hypothesis and the speculations that we make can be directly tested using tissues (cells) obtained from human beings.
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Hypertension Research Program, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark 07103-2714, USA.
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D000375:Aging / Q000235:genetics* / Q000473:pathology; D016922:Cellular Senescence; D006801:Humans; D006973:Hypertension / Q000235:genetics* / Q000473:pathology / Q000503:physiopathology; D016615:Telomere / Q000235:genetics*