The cytoprotective effect of iloprost against carbon tetrachloride induced necrosis in rat liver.
The aim of this study was to investigate the cytoprotective effect of Iloprost on the liver against carbon tetrachloride induced necrosis. The serum histamine-like activity was found to be increased when compared with that of controls after treatment with carbon tetrachloride for 18 weeks while prostaglandin E2- and leukotriene C4-like activities were unchanged. After pretreatment with Iloprost for 18 weeks the increased activity of histamine was found to be unchanged while prostaglandin E2-like activity was increased. It is concluded that Iloprost protects the liver against carbon tetrachloride-induced damage and reduces the level of histamine that has a role in the pathogenesis of portal hypertension.
Bozkurt
S
S
Department of General Surgery, Faculty of Medicine, Gazi University, Ankara, Turkey.
Ersoy
E
E
Tekýn
H E
HE
Bayram
O
O
Anadol
Z
Z
Onuk
E
E
Ercan
Z S
ZS
D000818:Animals; D002251:Carbon Tetrachloride / Q000008:administration & dosage / Q000633:toxicity*; D015232:Dinoprostone / Q000097:blood; D004195:Disease Models, Animal; D005260:Female; D006632:Histamine / Q000097:blood; D006975:Hypertension, Portal / Q000188:drug therapy / Q000517:prevention & control; D016285:Iloprost / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D007279:Injections, Subcutaneous; D017997:Leukotriene C4 / Q000097:blood; D008099:Liver / Q000166:cytology / Q000187:drug effects / Q000473:pathology; D008106:Liver Cirrhosis, Experimental / Q000139:chemically induced / Q000188:drug therapy* / Q000517:prevention & control; D008297:Male; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*
D010975:Platelet Aggregation Inhibitors; D014665:Vasodilator Agents; D017997:Leukotriene C4; D006632:Histamine; D002251:Carbon Tetrachloride; D016285:Iloprost; D015232:Dinoprostone