Regression of uterine low-grade smooth-muscle tumors metastatic to the lung after oophorectomy.
BACKGROUND
Metastatic uterine low-grade smooth-muscle tumors may present with pulmonary symptoms and radiographic lung abnormalities consistent with metastatic neoplasms. Ovarian hormone stimulation of these smooth-muscle tumors has been suggested, but the role of surgical or medical oophorectomy has not been established in patients with metastatic disease.


METHODS
Two women with histologically confirmed uterine low-grade smooth-muscle tumors metastatic to the lung had progressive and complete tumor regression after oophorectomy and no further therapy.


CONCLUSIONS
Some uterine low-grade smooth-muscle tumors metastatic to the lung regress after oophorectomy. Removing ovarian hormone stimulation may result in complete tumor regression without the need for further therapy.
Abu-Rustum
N R
NR
Gynecology Service, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.
Curtin
J P
JP
Burt
M
M
Jones
W B
WB
D000328:Adult; D003937:Diagnosis, Differential; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007889:Leiomyoma / Q000000981:diagnostic imaging / Q000601:surgery*; D007890:Leiomyosarcoma / Q000000981:diagnostic imaging / Q000556:secondary* / Q000601:surgery*; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary* / Q000601:surgery*; D010052:Ovariectomy; D011859:Radiography; D012074:Remission Induction; D014594:Uterine Neoplasms / Q000473:pathology*