title: Chronic lung disease in very low birthweight infants: a 5-year review.
abstract: OBJECTIVE
  To determine the incidence, clinical spectrum and outcome of very low birthweight (VLBW) infants with chronic lung disease (CLD), and evaluate associated factors.
  
  
  METHODS
  Retrospective review of 265 VLBW infants managed in the NICU from January 1988 to December 1992.
  
  
  RESULTS
  The overall neonatal survival rate for VLBW infants was 83%. Sixty-five (25%) infants had CLD, of whom 42% had severe CLD. Mortality in infants with CLD was 11%. In contrast with infants without CLD, CLD infants had significantly higher risk of adverse neurodevelopment with cerebral palsy documented in 13.5% and functional disability recorded in 34.6% at 2 years corrected age. Factors associated with the development of CLD included; decreasing birthweight (OR 0.98, CI 0.97-0.99), septicaemia (OR 4.96, CI 1.57-15.65), necrotizing enterocolitis (OR 119.07, CI 4.98-2845.04), hyaline membrane disease (OR 5.34, CI 1.83-15.55), patent ductus arteriosus (OR 4.46, CI 1.75-11.36) and increasing fraction of inspired oxygen concentration in the first week of life (OR 1.09, CI 1.04-1.14).
  
  
  CONCLUSIONS
  Chronic lung disease occurs frequently in VLBW infants and is associated with a high incidence of adverse neurodevelopment. Further studies to clarify the role of non-respiratory factors such as patent ductus arteriosus (PDA) and sepsis in the pathogenesis of CLD may reduce the incidence or prevent the development of CLD in these preterm infants.
authors.affiliation: Department of Neonatology, Singapore General Hospital, Singapore.
authors.forename: C L
authors.initials: CL
authors.lastname: Yeo
authors.forename: S
authors.initials: S
authors.lastname: Choo
authors.forename: L Y
authors.initials: LY
authors.lastname: Ho
mesh_terms: D002547:Cerebral Palsy / Q000453:epidemiology; D016009:Chi-Square Distribution; D002908:Chronic Disease; D016001:Confidence Intervals; D002658:Developmental Disabilities / Q000453:epidemiology; D006801:Humans; D007231:Infant, Newborn; D019102:Infant, Very Low Birth Weight; D016015:Logistic Models; D008171:Lung Diseases / Q000453:epidemiology*; D016017:Odds Ratio; D012189:Retrospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index; D012846:Singapore / Q000453:epidemiology; D017741:Survivors / Q000706:statistics & numerical data*; D016896:Treatment Outcome