Outcome and lineage involvement in t(12;21) childhood acute lymphoblastic leukaemia.
The t(12;21)(p13;q22) translocation has been described recently as the most recurrent genetic lesion in paediatric acute lymphoblastic leukaemias (ALLs). It has also been associated with B-precursor lineage involvement and good outcome. We tested 51 diagnostic paediatric ALLs and found 11 cases with molecular evidence of the t(12;21). Interestingly, amongst t(12;21) positive patients, we report three cases with hybrid phenotype, and two cases showing an aggressive and fatal disease. Our data show that the t(12;21) does not represent an independent good-risk indicator. Long follow-ups and additional molecular investigations are needed to assess the prognostic and pathogenetic relevance of t(12;21) in childhood ALLs.
Lanza
C
C
Ospedale San Luigi Gonzaga, Orbassano, Dipartimento di Scienze Pediatriche e dell'Adolescenza, University of Torino, Italy.
Volpe
G
G
Basso
G
G
Gottardi
E
E
Barisone
E
E
Spinelli
M
M
Ricotti
E
E
Cilli
V
V
Perfetto
F
F
Madon
E
E
Saglio
G
G
D019070:Cell Lineage; D002648:Child; D002675:Child, Preschool; D002881:Chromosomes, Human, Pair 12; D002891:Chromosomes, Human, Pair 21; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D008297:Male; D010641:Phenotype; D016133:Polymerase Chain Reaction; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics*; D011379:Prognosis; D014178:Translocation, Genetic