[Reaction of cells of subcutaneous connective tissue to the activation and blockade of the peptidergic system].
Changes in the quantitative composition of subcutaneous connective tissue cells were examined after activation and blockade of the peripheral peptidergic system with capsaicin. The activating dose (5 mg/kg) of the agent was found to increase the quantity of mast cells in the subcutaneous connective tissue. Its toxic dose (200 mg/kg) elevated the histiocytic and fibroblastic index while the number of mast cells reduced. The same reaction was seen in surgically impaired tissue innervation. It is concluded that peptidergic capsaicin-sensitive neurons play a role in the development of neurogenic dystrophy and this process involves connective tissue cell elements.
Vorob'eva
N F
NF
Kniazev
G G
GG
Spiridonov
V K
VK
Zhukova
E M
EM
D000818:Animals; D002211:Capsaicin / Q000494:pharmacology*; D003238:Connective Tissue / Q000187:drug effects* / Q000378:metabolism; D003239:Connective Tissue Cells; D008297:Male; D008407:Mast Cells / Q000187:drug effects* / Q000378:metabolism; D009479:Neuropeptides / Q000819:agonists* / Q000037:antagonists & inhibitors; D051381:Rats; D017208:Rats, Wistar
D009479:Neuropeptides; D002211:Capsaicin
Reaktsiia kletok podkozhnoĭ soedinitel'noĭ tkani na aktivatsiiu i blokadu peptidergicheskoĭ sistemy.