The influence of exercise on albumin excretion rate in borderline hypertensives and in offspring of hypertensive parents.
We investigated exercise induced urinary albumin excretion rate (UAE)(ex-UAE) in patients with borderline hypertension (BH) compared to normotensives with positive-PFH and negative-NFH family history of hypertension. The study population consisted of 20 young, non-obese males with BH defined according to WHO criteria and confirmed by 24 h ambulatory blood pressure (ABP) and 40 healthy matched normotensives (PFH = 20 and NFH = 20). Twenty-four hour UAE was assessed by day and night time urine collection. BH and normotensive subjects performed a 20 min ergometric graded exercise test. The relationship between 24 h UAE, 24 h ABP and 2-D-echocardiographic left ventricular mass index (LVMI) were examined. The three groups did not differ in 24 h UAE. Exercise induced a significant increase in UAE only in BH. Exercise induced UAE was greater in BH compared to normotensives: BH = 54.3(21-125), PFH = 37.6(13-62), NFH = 9.7(0-35)micrograms/min, data expressed as median (I quartile-III quartile). Pooled data from all three groups showed a positive correlation between ex-UAE and systolic BP (SBP) during night time (by multiple regression analysis). In conclusion, BH without other known cardiovascular risk factors, moderate dynamic exercise induced an excessive increase in UAE.
Purzycki
Z
Z
Cardiac Diagnostic Center, Medical Academy, Gdansk, Poland.
Wyrzykowski
B
B
Gockowski
K
K
Winnicki
M M
MM
Kazmirowicz
M
M
Krupa-Wojciechowska
B
B
Sowers
J R
JR
D000419:Albuminuria / Q000235:genetics / Q000503:physiopathology*; D001794:Blood Pressure; D015444:Exercise; D005080:Exercise Test; D006801:Humans; D006973:Hypertension / Q000235:genetics / Q000503:physiopathology* / Q000652:urine; D012307:Risk Factors