title: Lamotrigine therapy in infantile neuronal ceroid lipofuscinosis (INCL).
abstract: Since 1990, altogether 16 INCL patients received lamotrigine (LTG) because of intractable epilepsy. The response to LTG was favorable in 15/16 children. The severity of seizures decreased significantly in 15/16 patients, the frequency of seizures decreased in 14/16, and the effects were maintained. In addition, LTG had a beneficial effect on the well-being of 14/16 children. LTG failed to maintain it's efficacy in monotherapy. No severe side effects were found.
authors.affiliation: Children's Hospital, University of Helsinki.
authors.forename: L
authors.initials: L
authors.lastname: Aberg
authors.forename: H
authors.initials: H
authors.lastname: Heiskala
authors.forename: S L
authors.initials: SL
authors.lastname: Vanhanen
authors.forename: J J
authors.initials: JJ
authors.lastname: Himberg
authors.forename: G
authors.initials: G
authors.lastname: Hosking
authors.forename: A
authors.initials: A
authors.lastname: Yuen
authors.forename: P
authors.initials: P
authors.lastname: Santavuori
mesh_terms: D000293:Adolescent; D000328:Adult; D000927:Anticonvulsants / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D004359:Drug Therapy, Combination; D004569:Electroencephalography / Q000187:drug effects; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D000077213:Lamotrigine; D009460:Neurologic Examination / Q000187:drug effects; D009472:Neuronal Ceroid-Lipofuscinoses / Q000188:drug therapy*; D016896:Treatment Outcome; D014227:Triazines / Q000627:therapeutic use*
chemical_list: D000927:Anticonvulsants; D014227:Triazines; D000077213:Lamotrigine