Imipenem-cilastatin-induced leukocytoclastic vasculitis.
A maculopapular rash has been associated with the administration of imipenem-cilastatin, an antibiotic that was used for treatment of a postoperative infection. This is a first-time association of imipenem with a leukocytoclastic vasculitic reaction. Leukocytoclastic vasculitis has been previously documented with ciprofloxacin, zidovudine, piperazine, and lithium.
Reiner
M R
MR
Brunetti
V A
VA
D000368:Aged; D015377:Cilastatin / Q000008:administration & dosage / Q000009:adverse effects; D000077728:Cilastatin, Imipenem Drug Combination; D004338:Drug Combinations; D003875:Drug Eruptions / Q000209:etiology*; D004359:Drug Therapy, Combination / Q000009:adverse effects* / Q000627:therapeutic use; D006215:Hallux Valgus / Q000601:surgery; D006801:Humans; D015378:Imipenem / Q000008:administration & dosage / Q000009:adverse effects; D008297:Male; D013203:Staphylococcal Infections / Q000188:drug therapy; D013530:Surgical Wound Infection / Q000188:drug therapy; D018366:Vasculitis, Leukocytoclastic, Cutaneous / Q000139:chemically induced*
D004338:Drug Combinations; D015377:Cilastatin; D015378:Imipenem; D000077728:Cilastatin, Imipenem Drug Combination