title: Comparison of the intraosseous biocompatibility of Vitremer and super EBA by implantation into the mandible of rabbits.
abstract: OBJECTIVE
  This study compared the intraosseous biocompatibility of Vitremer, a new hydrophilic glass-ionomer cement, to that of Super EBA.
  
  
  METHODS
  Twenty-two New Zealand rabbits were anesthetized, the mandibular bone exposed, and two holes were drilled through the cortical plate. The materials were loaded into silicone carriers and inserted into the mandibles. Eleven rabbits were killed 4 weeks after implantation, 11 animals after 12 weeks. The mandibles were prepared with standard histologic procedures; the tissue reactions were graded from none to very severe.
  
  
  RESULTS
  At 4 weeks Vitremer implants showed very slight to slight reactions, and the Super EBA implants showed slight reactions and one moderate reaction with no significant difference between the two materials. At 12 weeks, bone healing had occurred, despite the persistence of some fibrous tissue interposition. The reactions were classified as none to very slight for Vitremer and very slight to slight for EBA. Statistical analysis showed better results for Vitremer at 12 weeks.
  
  
  CONCLUSIONS
  The intraosseous biocompatibility of Vitremer was similar at 4 weeks and superior at 12 weeks to that of Super EBA. Its other properties should be evaluated before considering its use in clinical practice.
authors.affiliation: Department of Restorative Dentistry, Marseilles Dental School, France.
authors.forename: H
authors.initials: H
authors.lastname: Tassery
authors.forename: M
authors.initials: M
authors.lastname: Remusat
authors.forename: G
authors.initials: G
authors.lastname: Koubi
authors.forename: W J
authors.initials: WJ
authors.lastname: Pertot
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000633:toxicity; D003188:Composite Resins / Q000633:toxicity*; D017220:Dentin-Bonding Agents / Q000633:toxicity*; D005899:Glass Ionomer Cements / Q000633:toxicity*; D008334:Mandible / Q000187:drug effects*; D008422:Materials Testing; D019736:Prostheses and Implants / Q000009:adverse effects; D011817:Rabbits; D012387:Root Canal Filling Materials / Q000633:toxicity*; D018709:Statistics, Nonparametric
chemical_list: D001672:Biocompatible Materials; D003188:Composite Resins; D017220:Dentin-Bonding Agents; D005899:Glass Ionomer Cements; D012387:Root Canal Filling Materials; C084550:Vitremer; C084074:Super EBA