title: The patient with chronic cough.
abstract: The most effective management of cough is specific therapy, which results in a greater than 90% response rate, so the cause should be thoroughly investigated. A chest x-ray should be taken early in the clinical investigation of chronic cough. The three most common causes of chronic cough when chest x-rays are normal are postnasal drip, bronchial asthma and gastro-oesophageal reflux. Chronic cough has more than one cause in 20% of patients, so therapy may need to be directed at multiple causes. Gastro-oesophageal reflux may complicate cough from any cause because a cough-reflux feedback cycle can develop. Hence, a four-week trial of an H2-receptor antagonist is indicated in patients with unexplained chronic cough where the history, physical examination, chest x-ray, lung function tests, ear/nose/throat examination and home peak flow monitoring all fail to elucidate a cause. Non-specific therapy should be reserved for when no diagnosis can be made, or when therapy is likely to be ineffective (e.g., lung malignancy).
authors.affiliation: Respiratory Unit, Concord Repatriation General Hospital, Sydney, NSW. ajing@thoracic-med.aust.com
authors.forename: A J
authors.initials: AJ
authors.lastname: Ing
authors.forename: A B
authors.initials: AB
authors.lastname: Breslin
mesh_terms: D000328:Adult; D001999:Bronchoscopy; D002908:Chronic Disease; D003371:Cough / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D005764:Gastroesophageal Reflux / Q000150:complications; D006801:Humans; D008991:Monitoring, Physiologic; D013147:Spirometry