title: Epidermization in the esophageal mucosa: unusual epithelial changes clearly detected by Lugol's staining.
abstract: A 58-year-old Japanese man with superficial esophageal cancer accompanied by unusual epithelial changes, including esophageal mucosal epidermization, is reported. Staining with Lugol's iodine clearly showed irregular unstained lesions, which could not be seen clearly macroscopically, in the resected specimen. Histologic examination of the irregular unstained areas showed definite granular and horny layers regarded as epidermization, acanthosis with slight nuclear enlargement, and epithelial atrophy. The immunohistochemical staining patterns of keratins in the epidermized and atrophic lesions were similar to those in the epidermis, and the keratin staining patterns of the acanthotic lesion were similar to those of the oral epithelium.
authors.affiliation: Division of Pathology, National Cancer Center Research Institute and Hospital, Tokyo, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Nakanishi
authors.forename: A
authors.initials: A
authors.lastname: Ochiai
authors.forename: T
authors.initials: T
authors.lastname: Shimoda
authors.forename: H
authors.initials: H
authors.lastname: Yamaguchi
authors.forename: Y
authors.initials: Y
authors.lastname: Tachimori
authors.forename: H
authors.initials: H
authors.lastname: Kato
authors.forename: H
authors.initials: H
authors.lastname: Watanabe
authors.forename: S
authors.initials: S
authors.lastname: Hirohashi
mesh_terms: D004396:Coloring Agents; D004817:Epidermis / Q000473:pathology*; D004938:Esophageal Neoplasms / Q000378:metabolism / Q000473:pathology*; D004947:Esophagus / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D007454:Iodides; D008297:Male; D008875:Middle Aged; D009092:Mucous Membrane / Q000378:metabolism / Q000473:pathology
chemical_list: D004396:Coloring Agents; D007454:Iodides; C010389:Lugol's solution