[The effect of substances with nootropic activity on oxidative phosphorylation in brain mitochondria in acute craniocerebral trauma].
An open craniocerebral trauma was simulated in rat experiments. Oxidative phosphorylation in the brain mitochondria was studied by polygraphy 24 h after the trauma. It was found that trauma to the brain leads to inhibition of respiration in mitochondria in various metabolic states. Nooglutil in a dose of 50 mg/kg prevents these changes. Nooglutil is more effective than picamilon (500 mg/kg) and piriditol (100 mg/kg).
Novikov
V E
VE
Kovaleva
L A
LA
D000208:Acute Disease; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D001930:Brain Injuries / Q000188:drug therapy / Q000378:metabolism*; D004353:Drug Evaluation, Preclinical; D005260:Female; D008297:Male; D008928:Mitochondria / Q000187:drug effects* / Q000378:metabolism; D018697:Nootropic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D010085:Oxidative Phosphorylation / Q000187:drug effects*; D051381:Rats; D014950:Wounds, Penetrating / Q000188:drug therapy / Q000378:metabolism*
D018697:Nootropic Agents
Vliianie veshchestv s nootropnoĭ aktivnost'iu na okislitel'noe fosforilirovanie v mitokhondriiakh mozga pri ostroĭ cherepno-mozgovoĭ travme.