title: Low selenium diet increases the dopamine turnover in prefrontal cortex of the rat.
abstract: It has been proposed that interaction of catecholamines and indoleamines with free radicals may result in the formation of endogenous neurotoxins. In order to better understand the mechanisms involved in neurodegenerative disorders showing evidence of oxidative stress, we have studied the basal concentrations and the turnover rates of dopamine, noradrenaline, serotonin and their metabolites in the prefrontal cortex of rats that were fed on control or low selenium diets. Nutritional deficit of selenium decreases the brain antioxidant protection in experimental conditions by the decrease in glutathione peroxidase activity. The dopamine and serotonin turnover increased and noradrenaline and 5-hydroxy-3-indoleacetic acid turnover decreased compared to experimental control animals. The increase of dopamine turnover in experimental rats was accompanied by an increase in tyrosine hydroxylase activity. These results suggest that the decrease of brain protection against oxidative damage could induce brain damage by disturbing the turnover rate of some monoamines.
authors.affiliation: Departamento de Bioquimica, Bromatología y Toxicologia, Facultad de Farmacia, Universidad de Sevilla, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Castaño
authors.forename: A
authors.initials: A
authors.lastname: Ayala
authors.forename: J A
authors.initials: JA
authors.lastname: Rodríguez-Gómez
authors.forename: A J
authors.initials: AJ
authors.lastname: Herrera
authors.forename: J
authors.initials: J
authors.lastname: Cano
authors.forename: A
authors.initials: A
authors.lastname: Machado
mesh_terms: D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism; D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D015153:Blotting, Western; D004032:Diet; D004298:Dopamine / Q000378:metabolism*; D005260:Female; D005979:Glutathione Peroxidase / Q000378:metabolism; D006719:Homovanillic Acid / Q000378:metabolism; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D009638:Norepinephrine / Q000378:metabolism; D017397:Prefrontal Cortex / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D012643:Selenium / Q000008:administration & dosage*; D012701:Serotonin / Q000378:metabolism
chemical_list: D000975:Antioxidants; D015102:3,4-Dihydroxyphenylacetic Acid; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D005979:Glutathione Peroxidase; D012643:Selenium; D004298:Dopamine; D009638:Norepinephrine; D006719:Homovanillic Acid