title: Proximal gastric motility functions are normal in severe obesity.
abstract: The role of altered gastric motor functions for the development of obesity is still unclear. In this study, we investigated whether severe obesity is related to gastric dysfunctions or to abnormal perception in response to distension. 31 obese patients and 20 healthy volunteers were studied using an electronic barostat. Basal gastric tone, gastric accommodation, and perception in response to distension were not altered in obese patients. The median minimal distending pressure, reflecting the intra-abdominal pressure, was significantly elevated in obese patients, being 12 versus 7 mm Hg, respectively (p < 0.0001). We conclude that the proximal gastric motility, including perception and accommodation in response to intragastric distension, is not impaired in severe obesity. Whether disturbances of gastric reflex relaxation in response to a meal are involved in the pathogenesis of obesity remains to be established.
authors.affiliation: Department of Internal Medicine I, University of Ulm, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Klatt
authors.forename: O
authors.initials: O
authors.lastname: Pieramico
authors.forename: C
authors.initials: C
authors.lastname: Güthner
authors.forename: H H
authors.initials: HH
authors.lastname: Ditschuneit
authors.forename: B
authors.initials: B
authors.lastname: Glasbrenner
authors.forename: K
authors.initials: K
authors.lastname: Beckh
authors.forename: G
authors.initials: G
authors.lastname: Adler
mesh_terms: D000328:Adult; D000367:Age Factors; D015992:Body Mass Index; D005260:Female; D005769:Gastrointestinal Motility / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009767:Obesity, Morbid / Q000378:metabolism*; D009929:Organ Size; D012737:Sex Factors