Regulation of beta 2-adrenergic receptors on mononuclear leukocytes in patients with acute ischemic heart disease.
OBJECTIVE
To investigate relationships between acute adrenergic stress, plasma catecholamine concentrations, and beta 2-adrenergic receptors.


METHODS
Prospective, descriptive study.


METHODS
Emergency medical service at a university hospital.


METHODS
Twenty-seven patients with out-of-hospital cardiac arrest (n = 11), myocardial infarction (n = 6), and angina pectoris (n = 10), and 12 control subjects.


METHODS
None.


RESULTS
Mononuclear leukocyte beta 2-adrenergic receptor density and affinity were measured in patients 15 mins after successful cardiopulmonary resuscitation and after the diagnosis of myocardial infarction or angina pectoris, respectively, and were measured as well in control subjects. Plasma concentrations of catecholamines, glucose, and lactate were simultaneously measured with heart rate and blood pressure. After cardiac arrest, the density of beta 2-adrenergic receptors (1858 +/- 188 sites/cell [p < .01]), plasma epinephrine concentration (31,990 +/- 14,526 pg/mL [174.6 +/- 79.3 nmol/L] [p < .01]), heart rate (100 +/- 6 beats/min [p < .01]), glucose concentration (14.9 +/- 0.8 mmol/L [p < .01]), and lactate concentration (10.9 +/- 0.6 mmol/L [p < .01]) were increased in patients compared with those values in healthy controls.


CONCLUSIONS
Acute maximal stress, such as after cardiac arrest, is associated with an increase in the density of beta 2-adrenergic receptors on mononuclear leukocytes derived from patients after successful cardiopulmonary resuscitation.
Prengel
A W
AW
Department of Anesthesiology and Critical Care Medicine, University of Ulm, Germany.
Lindner
K H
KH
Anhäupl
T
T
Trunk
E
E
Georgieff
M
M
Lurie
K G
KG
D000208:Acute Disease; D000368:Aged; D000787:Angina Pectoris / Q000378:metabolism / Q000503:physiopathology; D001786:Blood Glucose / Q000032:analysis; D016887:Cardiopulmonary Resuscitation; D002395:Catecholamines / Q000097:blood; D004562:Electrocardiography; D005260:Female; D006323:Heart Arrest / Q000378:metabolism* / Q000503:physiopathology; D006439:Hemodynamics; D006801:Humans; D019344:Lactic Acid / Q000032:analysis; D007963:Leukocytes, Mononuclear / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000378:metabolism / Q000503:physiopathology; D017202:Myocardial Ischemia / Q000378:metabolism* / Q000503:physiopathology; D011446:Prospective Studies; D011943:Receptors, Adrenergic, beta / Q000378:metabolism*
D001786:Blood Glucose; D002395:Catecholamines; D011943:Receptors, Adrenergic, beta; D019344:Lactic Acid