title: N-methyl-D-aspartate enhancement of phasic responses in primate neocortex.
abstract: In area 17 of the awake macaque, disinhibition by blockade of GABA(A) receptors results in a marked elevation in neuronal excitability, with a particular focus in the supragranular laminae. We examined the possibility that the excitatory supragranular response is N-methyl-D-aspartate (NMDA)-mediated. Laminar activity profiles consisting of flash-evoked field potential, current source density (CSD) and multiunit activity (MUA) measures were obtained during striate cortex penetrations using multicontact electrodes that incorporated single or double microinjection cannulae. Profiles were recorded before and at successive time points after bicuculline induction of disinhibition. Both the noncompetitive NMDA antagonist MK-801 and the competitive antagonist APV reversed bicuculline effects, producing a normal laminar activity profile. NMDA-mediated enhancement of excitatory responses in the supragranular laminae of neocortex is believed to play a role in normal signal processing, as well as in epileptic manifestations.
authors.affiliation: Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA. cschroed@iris.rfmh.org
authors.forename: C E
authors.initials: CE
authors.lastname: Schroeder
authors.forename: D C
authors.initials: DC
authors.lastname: Javitt
authors.forename: M
authors.initials: M
authors.lastname: Steinschneider
authors.forename: A D
authors.initials: AD
authors.lastname: Mehta
authors.forename: S J
authors.initials: SJ
authors.lastname: Givre
authors.forename: H G
authors.initials: HG
authors.lastname: Vaughan
authors.forename: J C
authors.initials: JC
authors.lastname: Arezzo
mesh_terms: D000818:Animals; D001640:Bicuculline / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D016291:Dizocilpine Maleate / Q000008:administration & dosage / Q000494:pharmacology*; D005074:Evoked Potentials, Visual / Q000187:drug effects / Q000502:physiology*; D008252:Macaca fascicularis; D008297:Male; D008845:Microinjections; D016202:N-Methylaspartate / Q000502:physiology*; D011963:Receptors, GABA-A / Q000502:physiology; D016194:Receptors, N-Methyl-D-Aspartate / Q000502:physiology; D013997:Time Factors; D014793:Visual Cortex / Q000187:drug effects / Q000502:physiology*
chemical_list: D011963:Receptors, GABA-A; D016194:Receptors, N-Methyl-D-Aspartate; C017069:bicuculline methiodide; D016202:N-Methylaspartate; D016291:Dizocilpine Maleate; D001640:Bicuculline