title: Unidentified antioxidant defences of human plasma in immobilized patients: a possible relation to basic metabolic rate.
abstract: Plasma total peroxyl radical scavenging capacity was studied in terminal patients who were chronically immobilized because of an acute (stroke) or chronic neurodegenerative disease (Alzheimer's disease). A luminometric assay was used to measure total antioxidant capacity (TRAP). The immobilized patients showed significant decrease in TRAP primarily because of a decrease in the concentration of unknown antioxidants. Our results suggest that human plasma may contain unknown antioxidants, the regulation of which could be related to the basic metabolic rate.
authors.affiliation: Laboratory of Neurobiology, Medical School, University of Tampere, Finland.
authors.forename: R
authors.initials: R
authors.lastname: Aejmelaeus
authors.forename: T M
authors.initials: TM
authors.lastname: Ketelä
authors.forename: T
authors.initials: T
authors.lastname: Pirttilä
authors.forename: A
authors.initials: A
authors.lastname: Hervonen
authors.forename: H
authors.initials: H
authors.lastname: Alho
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000378:metabolism; D000975:Antioxidants / Q000378:metabolism*; D001205:Ascorbic Acid / Q000097:blood; D001481:Basal Metabolism; D002561:Cerebrovascular Disorders / Q000378:metabolism; D005260:Female; D006801:Humans; D007103:Immobilization; D008875:Middle Aged; D013438:Sulfhydryl Compounds / Q000097:blood; D014527:Uric Acid / Q000097:blood; D014810:Vitamin E / Q000097:blood
chemical_list: D000975:Antioxidants; D013438:Sulfhydryl Compounds; D014810:Vitamin E; D014527:Uric Acid; D001205:Ascorbic Acid