title: The risk factor profile of recto-sigmoid adenomas: a prospective screening study of 665 patients in a clinical rehabilitation centre.
abstract: During a prospective screening study for recto-sigmoid adenomatous polyps, the influence of the following risk factors was evaluated: age; gender; body mass index; heredity for colorectal malignancy; diabetes; hypertension; constipation; previous gastric surgery; previous gastric acid inhibition; alcohol and cigarette consumption; serum cholesterol; serum triglycerides; and serum gastrin. Screening fibre-sigmoidoscopy of 665 patients (aged between 50 and 60 years) at a clinical rehabilitation centre for gastrointestinal and metabolic diseases showed that 146 had one or several adenomas. The study population was overweight by a mean of about 15%. Comparison of those with and those without adenoma using univariate analysis, showed that the group with adenomas had higher serum triglyceride values, drank more alcohol on a regular or excessive basis, were more frequent smokers, and had a tendency to raised fasting serum glucose. In a multivariate analysis, age, high serum triglycerides and high alcohol consumption were risk factors for recto-sigmoid adenomas. The risk factor profile identified in this study may help in the selection of individuals for screening sigmoidoscopy from a similar background population. It also identifies target conditions for primary prevention of colorectal neoplasia.
authors.affiliation: Marbachtalklinik, Bad Kissingen, Germany.
authors.forename: B
authors.initials: B
authors.lastname: Manus
authors.forename: R P
authors.initials: RP
authors.lastname: Adang
authors.forename: A W
authors.initials: AW
authors.lastname: Ambergen
authors.forename: R
authors.initials: R
authors.lastname: Brägelmann
authors.forename: U
authors.initials: U
authors.lastname: Armbrecht
authors.forename: R W
authors.initials: RW
authors.lastname: Stockbrügger
mesh_terms: D000236:Adenoma / Q000097:blood / Q000453:epidemiology / Q000517:prevention & control*; D017677:Age Distribution; D000437:Alcoholism / Q000150:complications; D000704:Analysis of Variance; D005260:Female; D005858:Germany / Q000453:epidemiology; D006801:Humans; D016015:Logistic Models; D008297:Male; D008403:Mass Screening / Q000379:methods; D008875:Middle Aged; D015999:Multivariate Analysis; D009765:Obesity / Q000150:complications; D011446:Prospective Studies; D012004:Rectal Neoplasms / Q000097:blood / Q000453:epidemiology / Q000517:prevention & control*; D012047:Rehabilitation Centers; D012307:Risk Factors; D017678:Sex Distribution; D012811:Sigmoid Neoplasms / Q000097:blood / Q000453:epidemiology / Q000517:prevention & control*; D012812:Sigmoidoscopy; D012907:Smoking / Q000009:adverse effects; D014280:Triglycerides / Q000097:blood
chemical_list: D014280:Triglycerides