Interleukin-8 in urine: a new diagnostic parameter for intra-amniotic infection after premature rupture of the membranes.
Interleukin-8 (IL-8), a 72 amino acid peptide secreted by cells of the immune system and of the amnion, chorion and decidua, was measured in women in late pregnancy. IL-8 was detected in the urine of 91 of 104 women with premature rupture of the fetal membranes, with values exceeding 1000 ng/L in cases of severe intra-amniotic infection. Women with urinary tract infections were excluded. The routine measurement of IL-8 in urine, together with C-reactive protein in serum, thus provides a low risk and technically simple approach to the assessment of intra-amniotic infection.
Stiemer
B
B
Department of Obstetrics and Gynaecology, Klinikum Benjamin Franklin, Free University of Berlin, Germany.
Buschmann
A
A
Bisson
S
S
Hensel
K
K
Gramm
H J
HJ
Hopp
H
H
Weitzel
H K
HK
D000650:Amnion; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000652:urine*; D006801:Humans; D016209:Interleukin-8 / Q000652:urine*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000175:diagnosis*; D011262:Pregnancy Trimester, Second; D011263:Pregnancy Trimester, Third; D011296:Prenatal Diagnosis / Q000379:methods; D012680:Sensitivity and Specificity
D016209:Interleukin-8