[Bactericidal effects of maxaquin on mycobacterium tuberculosis].
Maxaquine is a fluoroquinolone agent that is effective against Mycobacterium tuberculosis (MBT). The drug was tested for effects on MBT growth in the infected lung tissue in relation to its concentration and exposure time. The bactericidal effect was found to be achieved no earlier than 72 hours of its administration. The minimum bactericidal concentration of maxaquine was 2 micrograms/ml.
Kunichian
A D
AD
Russian NII of Tuberculosis, Department of Health RF, Moscow.
Mozhokina
G N
GN
Sokolova
G B
GB
Shapatava
M N
MN
D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology*; D015169:Colony Count, Microbial; D004305:Dose-Response Relationship, Drug; D024841:Fluoroquinolones; D066298:In Vitro Techniques; D008168:Lung / Q000166:cytology / Q000382:microbiology; D051379:Mice; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000254:growth & development; D015363:Quinolones / Q000494:pharmacology*
D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D015363:Quinolones; C053091:lomefloxacin
Bakteritsidnoe deistvie maksakvina na mikobakterii tuberkuleza.