alpha2,3-sialyltransferase mRNA and alpha2,3-linked glycoprotein sialylation are increased in malignant gliomas.
CMP-NeuAc: Galbeta1,3(4)GlcNAc alpha2,3-sialyltransferase (alpha2,3-ST) mRNA was expressed in human glioma specimens, human fetal astrocytes, and a panel of brain tumor cell lines. Maackia amurensis agglutinin staining revealed the presence of alpha2,3-linked sialic acids on glioma cell surfaces and extracellular matrices whereas normal human adult astrocytes were negative. Increased expression of alpha2,3-linked glycoprotein sialylation may play a role in glial tumorigenesis.
Yamamoto
H
H
The Chicago Institute of Neurosurgery and Neuroresearch, IL 60614, USA.
Saito
T
T
Kaneko
Y
Y
Kersey
D
D
Yong
V W
VW
Bremer
E G
EG
Mkrdichian
E
E
Cerullo
L
L
Leestma
J
J
Moskal
J R
JR
D000230:Adenocarcinoma / Q000378:metabolism; D001253:Astrocytes / Q000378:metabolism; D001254:Astrocytoma / Q000378:metabolism; D001932:Brain Neoplasms / Q000378:metabolism* / Q000556:secondary; D002236:Carbohydrate Conformation; D005909:Glioblastoma / Q000378:metabolism; D005910:Glioma / Q000378:metabolism*; D006023:Glycoproteins / Q000378:metabolism*; D006801:Humans; D012333:RNA, Messenger / Q000378:metabolism*; D012799:Sialyltransferases / Q000235:genetics*; D014407:Tumor Cells, Cultured; D000094663:beta-Galactoside alpha-2,3-Sialyltransferase
D006023:Glycoproteins; D012333:RNA, Messenger; D012799:Sialyltransferases; D000094663:beta-Galactoside alpha-2,3-Sialyltransferase; C000722087:ST3GAL1 protein, human