title: In vitro alkylating of alpha, beta-unsaturated amidoesters, diethyl pyridylmethylphosphonates and their cis-Pt(II)complexes.
abstract: The alkylating ability of alpha,beta-unsaturated amidoesters 1a-8d, diethyl pyridylmethylphosphonate esters and their cis-platinum(II) complexes has been investigated based on the test with 4-(4'-nitrobenzyl)pyridine (NBP) (Preussmann Test). Of the compounds tested for alkylating activity, only cis-platinum(II) phosphonate complexes were found to possess activity. The highest activity was found for CiS-[PtCl2(4-pmpe)2] where 4-pmpe is diethyl 4-pyridylmethylphosphonate. The results show a correlation between alkylating activity in vitro and cytotoxic activity in vivo for platinum(II) complexes.
authors.affiliation: Department of Pharmaceutical Chemistry and Drug Analysis, Medical University, Lódz, Poland.
authors.forename: L
authors.initials: L
authors.lastname: Najman-Bronzewska
authors.forename: J
authors.initials: J
authors.lastname: Ochocki
mesh_terms: D000577:Amides / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D018906:Antineoplastic Agents, Alkylating / Q000138:chemical synthesis* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D004952:Esters / Q000138:chemical synthesis* / Q000494:pharmacology; D007202:Indicators and Reagents; D007939:Leukemia L1210 / Q000188:drug therapy; D051379:Mice; D063065:Organophosphonates / Q000138:chemical synthesis* / Q000494:pharmacology; D009944:Organoplatinum Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D011725:Pyridines / Q000737:chemistry; D012510:Sarcoma 180 / Q000188:drug therapy
chemical_list: D000577:Amides; D018906:Antineoplastic Agents, Alkylating; D004952:Esters; D007202:Indicators and Reagents; D063065:Organophosphonates; D009944:Organoplatinum Compounds; D011725:Pyridines; C008633:4-(4-nitrobenzyl)pyridine