[The effect of specific immunotherapy on the concentration of some chemokines in BALF in patients with atopic bronchial asthma].
The cellular basis the mechanism of specific hyposensitization is still unclear. We studied the effect of immunotherapy on activity of interleukin-8 (IL-8) and monocyte activating and chemoattractant protein (MCAF/MCP1) in bronchoalveolar lavage fluid (BALF). 20 patients with atopic asthma took part in this study. 14 were treated with grass pollen extracts (Allergovit, Allergopharma, Germany) for 7 weeks and 6 of this group were not treated and served as control group. ELISA test (R&D, USA) was used to assess IL-8 and MCAF/MCP1 activity in one ml of BALF recovered before and after immunotherapy. The results indicate that immunotherapy induces the suppression of MCAF/MCP1 production and the increase of IL-8 production in BALF. These chemokines may have reciprocal control on inflammatory cells, which participate in creating of inflammatory changes in asthma.
Jahnz-Rózyk
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Kliniki Chorób Wewnetrznych i Pneumunologii Instytutu Medycyny Wewnetrznej Centralnego Szpitala Klinicznego Wojskowej Akademii Medycznej.
Kuna
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Pojda
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Pirozyńska
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D000328:Adult; D001249:Asthma / Q000276:immunology / Q000628:therapy*; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry*; D018925:Chemokines / Q000032:analysis*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007167:Immunotherapy; D007249:Inflammation / Q000276:immunology; D008297:Male; D010936:Plant Extracts / Q000008:administration & dosage; D006109:Poaceae / Q000276:immunology*; D011058:Pollen
D018925:Chemokines; D010936:Plant Extracts
Wpływ immunoterapii swoistej na stezenia niektórych chemokin w materiale z BAL u chorych na atopowa astme oskrzelow.