Morphology of lipid alterations in the epidermis: a review.
An overview of the morphological correlates of mammalian epidermal lipids and the cutaneous permeability barrier is provided. The following features are discussed: 1) ultrastructural characterization of the progressive lipid alterations accompanying normal stratum corneum (SC) formation; 2) effects of drugs/inhibitors that interfere with specific aspects of epidermal lipid metabolism; 3) lipid alterations in certain human skin disorders; 4) effects of selected topical emollients on SC lipid organization; and 5) potential pitfalls in interpretation of ultrastructural data in terms of cutaneous function and dysfunction.
Menon
G
G
Avon Products, Inc., Suffern, New York 10901, USA.
Ghadially
R
R
D000279:Administration, Cutaneous; D000818:Animals; D004643:Emollients / Q000627:therapeutic use; D004817:Epidermis / Q000648:ultrastructure*; D006801:Humans; D007642:Keratosis / Q000378:metabolism / Q000473:pathology / Q000628:therapy; D008051:Lipid Bilayers; D050356:Lipid Metabolism; D010539:Permeability
D004643:Emollients; D008051:Lipid Bilayers