title: Endophthalmitis after Lasiodiplodia theobromae corneal abscess.
abstract: BACKGROUND
  Lasiodiplodia theobromae is an exceptional cause of human keratomycosis.
  
  
  METHODS
  We treated a 53-year-old man with fungal keratitis, which had been treated with topical betamethasone and gentamicin for 1 month, and endophthalmitis due to Lasiodiplodia theobromae. Despite intensive systemic, topical and intravitreal fungicidal treatment, enucleation had to be performed.
  
  
  RESULTS
  The vitreous aspirate cultures were negative as of the second amphotericin intravitreal injection. However, histology revealed that the fungus was present in the cornea, ciliary body, iris and retina.
  
  
  CONCLUSIONS
  The use of topical steroids may worsen the outcome of the infection.
authors.affiliation: Service d'Ophtalmologie, Hôpital Saint Antoine, Paris, France.
authors.forename: V M
authors.initials: VM
authors.lastname: Borderie
authors.forename: T M
authors.initials: TM
authors.lastname: Bourcier
authors.forename: J L
authors.initials: JL
authors.lastname: Poirot
authors.forename: M
authors.initials: M
authors.lastname: Baudrimont
authors.forename: P
authors.initials: P
authors.lastname: Prudhomme de Saint-Maur
authors.forename: L
authors.initials: L
authors.lastname: Laroche
mesh_terms: D000038:Abscess / Q000188:drug therapy / Q000382:microbiology* / Q000473:pathology; D000935:Antifungal Agents / Q000008:administration & dosage / Q000627:therapeutic use; D003315:Cornea / Q000382:microbiology / Q000473:pathology; D004359:Drug Therapy, Combination; D009877:Endophthalmitis / Q000188:drug therapy / Q000382:microbiology* / Q000473:pathology; D015353:Eye Enucleation; D015821:Eye Infections, Fungal / Q000188:drug therapy / Q000382:microbiology / Q000473:pathology; D005500:Follow-Up Studies; D005938:Glucocorticoids / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D007634:Keratitis / Q000188:drug therapy / Q000382:microbiology* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D003904:Mitosporic Fungi / Q000302:isolation & purification*; D012160:Retina / Q000382:microbiology / Q000473:pathology; D014602:Uvea / Q000382:microbiology / Q000473:pathology
chemical_list: D000935:Antifungal Agents; D005938:Glucocorticoids