title: [Urinary interleukin-6 and interleukin-8 in females with urethral syndrome].
abstract: Interleukin-6 (IL-6) and interleukin-8 (IL-8) are important mediators of an inflammatory response. We measured creatinine-collected urinary levels of IL-6 and IL-8 by an enzyme-linked immunosorbent assay in 21 women with urethritis syndrome as well as 20 age-matched healthy women. Urine samples were collected before treatment and after 7 or 14 days of oral administration of sparfloxacin (100 mg once daily). Urinary IL-6 level was elevated in a patient with urethritis syndrome (41.1 pg/mgCr), while urinary IL-8 levels were elevated in 8 (range 13.3 to 560 pg/mgCr). On the other hand, none of the healthy controls showed any detectable urinary level of IL-6 and IL-8. Of the 9 patients with elevated urinary IL-6 or IL-8, symptomatic improvement was obtained after chemotherapy in 8 and urinary interleukins became undetectable in 7. Urinary IL-6 and IL-8 seem to have some role in the induction of urinary symptoms.
authors.affiliation: Department of Urology, Osaka Municipal Juso-Shimin Hospital.
authors.forename: R
authors.initials: R
authors.lastname: Yasumoto
authors.forename: M
authors.initials: M
authors.lastname: Kawano
authors.forename: M
authors.initials: M
authors.lastname: Senju
authors.forename: N
authors.initials: N
authors.lastname: Nishisaka
authors.forename: M
authors.initials: M
authors.lastname: Kyo
authors.forename: T
authors.initials: T
authors.lastname: Kishimoto
mesh_terms: D000890:Anti-Infective Agents / Q000008:administration & dosage; D005260:Female; D024841:Fluoroquinolones; D006801:Humans; D015850:Interleukin-6 / Q000652:urine*; D016209:Interleukin-8 / Q000652:urine*; D016555:Matched-Pair Analysis; D015363:Quinolones / Q000008:administration & dosage; D013577:Syndrome; D014526:Urethritis / Q000175:diagnosis* / Q000188:drug therapy
chemical_list: D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D015850:Interleukin-6; D016209:Interleukin-8; D015363:Quinolones; C061363:sparfloxacin