Bradykinin stimulates interleukin-6 and interleukin-8 secretion of human decidua derived cells.
Cytokines are known to participate in the process of parturition within a paracrine network in fetal membranes. Bradykinin can also contribute to this process, increasing the release of eicosanoids from decidua cells. In this study, we present evidence for a cross-link between bradykinin and the cytokines. Short and long term cultures of human decidua cells were incubated for 4 h and 24 h with and without bradykinin. IL-6 and IL-8 were determined in the supernatants by ELISA. Results show a large interindividual variability in the basal secretion of IL-6 and IL-8 and a clear increase in the secretion of both ILs in response to bradykinin. By this amplifying effect on cytokine secretion, bradykinin can initiate local and systemic effects of amniochorionitis.
Rehbock
J
J
I. Frauenklinik, Ludwig-Maximilians-Universität München, Klinikum Innenstadt, Munich, Germany.
Chondromatidou
A
A
Buchinger
P
P
Hermann
A
A
Jochum
M
M
D001920:Bradykinin / Q000494:pharmacology*; D002478:Cells, Cultured; D003656:Decidua / Q000378:metabolism*; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000378:metabolism*; D016209:Interleukin-8 / Q000378:metabolism*; D011247:Pregnancy
D015850:Interleukin-6; D016209:Interleukin-8; D001920:Bradykinin