[An elevation in the level of autoantibodies to nerve-growth factor in the blood serum of schizophrenic children].
The level of autoantibodies (AAB) to nerve growth factor (NGF) was examined in blood of mentally healthy children, children with early children schizophrenia as well as with Kanner's and Asperger's syndromes too. The elevated titer of AAB to NGF was determined in blood of children with acute, active state of disease; meanwhile the same titer wasn't changed in the state of stable remission or steady defective state as compared with control group. The correlation was found between the level of AAB to NGF and the degree of disease progression. The correlations which were revealed between AAB to NGF level and peculiarities of the clinical state of patients permitted to use this index as the objective marker of both the acuteness and the severity of the patient's state.
Bashina
V M
VM
Kozlova
I A
IA
Kliushnik
T P
TP
Simashkova
N V
NV
Danilovskaia
E V
EV
Gorbachevskaia
N L
NL
Turkova
I L
IL
Iakupova
L P
LP
Grachev
V V
VV
D000208:Acute Disease; D001321:Autistic Disorder / Q000145:classification / Q000175:diagnosis / Q000276:immunology; D001323:Autoantibodies / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D004569:Electroencephalography; D006801:Humans; D009414:Nerve Growth Factors / Q000276:immunology*; D012557:Schizoid Personality Disorder / Q000145:classification / Q000175:diagnosis / Q000276:immunology; D012561:Schizophrenia, Childhood / Q000145:classification / Q000175:diagnosis / Q000276:immunology*
D001323:Autoantibodies; D009414:Nerve Growth Factors
Povyshenie urovnia autoantitel k faktoru rosta nervov v syvorotke krovi deteĭ, bol'nykh shizofrenieĭ.