Effect of nordihydroguaretic acid and fluconazole on the LTC4/PGE2 ratio in the kidney of mice damaged by Candida albicans.
The kidney is a major target organ in generalized candidiasis. When mice were infected with C.albicans, prostaglandin E2 (PGE2)-like activity was found to be significantly decreased while leukotriene C4 (LTC4)-like activity increased in the kidneys within 10 days. The aim of this study is to investigate the effect of nordihydroguaretic (NDGA) and fluconazole on the LTC4/PGE2 ratio in the mice kidneys infected by proteinase (+) C. albicans. The LTC4/PGE2 ratio was found to be significantly decreased both in NDGA and fluconazole-pretreated groups. These results indicate that pretreatment with the lipoxygenase inhibitor NDGA and the antifungal drug fluconazole, protect the kidney against C. albicans infection. These results also indicate a possible role of arachidonic acid metabolites (increase LTC4 and decrease PGE2) in kidney damage due to C. albicans infection.
Kuştimur
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Department of Microbiology, Faculty of Medicine, Gazi University, Ankara, Turkey.
Memiş
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Kilinç
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Ercan
Z S
ZS
D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology / Q000627:therapeutic use; D002176:Candida albicans; D002177:Candidiasis / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D015232:Dinoprostone / Q000378:metabolism*; D005260:Female; D015725:Fluconazole / Q000494:pharmacology* / Q000627:therapeutic use; D006651:Histocytochemistry; D007668:Kidney / Q000201:enzymology / Q000378:metabolism* / Q000473:pathology; D017997:Leukotriene C4 / Q000378:metabolism*; D016859:Lipoxygenase Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D008297:Male; D009637:Masoprocol / Q000494:pharmacology* / Q000627:therapeutic use; D051379:Mice
D000935:Antifungal Agents; D016859:Lipoxygenase Inhibitors; D017997:Leukotriene C4; D009637:Masoprocol; D015725:Fluconazole; D015232:Dinoprostone