title: [Structural-functional changes in liver and brain in endotoxic shock (ultrastructural study)].
abstract: An additional clearance link forming the Kupffer's cell-hepatocyte microsystem that protects the body from endotoxemia was found in the early period of hepatic endotoxic shock. Sensory cortical neurons display dystrophic changes in the neurons of the sensory cortex and capillary exhibit hemodynamic disorders as plethora and enhanced permeability of the blood-brain barrier. In the intervening period of shock, there are first signs of block in the Kupffer's cell-hepatocyte system and drastically marked microcirculatory and dystrophic disorders. Lesions further progress in the nerve and glial cells, microvessels, and synapses of the sensory cortex. In late endotoxemia, there are cerebral and hepatic destructive changes that predispose to hepatocerebral insufficiency.
authors.forename: E A
authors.initials: EA
authors.lastname: Bardakhch'ian
authors.forename: N G
authors.initials: NG
authors.lastname: Kharlanova
mesh_terms: D000818:Animals; D001921:Brain / Q000503:physiopathology / Q000648:ultrastructure*; D004195:Disease Models, Animal; D004285:Dogs; D008099:Liver / Q000503:physiopathology / Q000648:ultrastructure*; D008297:Male; D011817:Rabbits; D051381:Rats; D012772:Shock, Septic / Q000473:pathology* / Q000503:physiopathology
vernacular_title: Strukturno-funktsional'nye izmeneniia pecheni i mozga pri éndotoksinovom shoke (ultrastrukturnoe issledovanie)