title: Lou Gehrig and amyotrophic lateral sclerosis. Is vitamin E to be revisited?
abstract: Investigators are beginning to reexamine the use of vitamin E for the treatment of amyotrophic lateral sclerosis. Vitamin E was isolated in the 1920s, and the results of animal studies led rapidly to clinical use. Regrettably, vitamin E did not ameliorate the progression of amyotrophic lateral sclerosis for Lou Gehrig, but more recent advances may identify subpopulations that do respond to vitamin E.
authors.affiliation: Department of Neurology, Ohio State University, Columbus, USA.
authors.forename: C R
authors.initials: CR
authors.lastname: Reider
authors.forename: G W
authors.initials: GW
authors.lastname: Paulson
mesh_terms: D000690:Amyotrophic Lateral Sclerosis / Q000188:drug therapy / Q000266:history*; D001484:Baseball / Q000266:history; D005197:Famous Persons; D049673:History, 20th Century; D006801:Humans; D014481:United States; D014810:Vitamin E / Q000266:history* / Q000627:therapeutic use
chemical_list: D014810:Vitamin E