A case of Turner syndrome with schizophrenia: genetic relationship between Turner syndrome and psychosis.
An 82-year-old woman with Turner syndrome and schizophrenia, and her 46-year-old daughter with schizophrenia are described. 45X/46XX chromosomal mosaicism was identified in the peripheral leukocytes of the mother, who showed several Turner dysmorphisms and cavum septi pellucidum in the brain. She had a normal reproductive life-span. The daughter resembled the mother in terms of schizophrenic symptoms, but she did not show any signs of Turner dysmorphism or chromosomal abnormality. The phenotype-karyotype relationship of Turner syndrome and the genetic relationship with psychosis are discussed.
Kawanishi
C
C
Fujisawa Hospital, Kanagawa, Japan.
Kono
M
M
Onishi
H
H
Ishii
N
N
Ishii
K
K
D000368:Aged; D001284:Atrophy / Q000473:pathology; D005260:Female; D006801:Humans; D007621:Karyotyping; D012559:Schizophrenia / Q000150:complications*; D012565:Schizophrenic Psychology; D012688:Septum Pellucidum / Q000473:pathology; D014424:Turner Syndrome / Q000150:complications* / Q000235:genetics* / Q000523:psychology; D014960:X Chromosome