title: RNA editing in kinetoplastid parasites: what to do with U.
abstract: The editing of the mitochondrial RNAs of kinetoplastid protozoa is a bizarre form of transcript maturation that involves insertion and deletion of uridylate residues. Editing leads to the formation of translational initiation and termination codons, the correction of gene-encoded reading frame shifts and the creation of complete reading frames in mRNAs. It is therefore an essential step in mitochondrial gene expression.
authors.affiliation: Dept of Biochemistry, University of Amsterdam, The Netherlands.
authors.forename: P
authors.initials: P
authors.lastname: Sloof
authors.forename: R
authors.initials: R
authors.lastname: Benne
mesh_terms: D000818:Animals; D056890:Eukaryota / Q000235:genetics* / Q000378:metabolism*; D005786:Gene Expression Regulation; D016254:Mutagenesis, Insertional; D012313:RNA / Q000378:metabolism*; D012323:RNA Processing, Post-Transcriptional; D000077278:RNA, Mitochondrial; D017384:Sequence Deletion; D014158:Transcription, Genetic; D014529:Uridine / Q000235:genetics
chemical_list: D000077278:RNA, Mitochondrial; D012313:RNA; D014529:Uridine