New aporphine alkaloids and cytotoxic constituents of Hernandia nymphaeifolia.
Two new aporphine alkaloids, (+)-N-hydroxyhernangerine (1) and N-formyldehydroovigerine (2) as minor bases, along with four known aporphines, (+)-magnoflorine, (+)-hernovine, (+)-N-methylhernovine, and (+)-laurotetanine, two known isoquinolones, thalifoline and northalifoline, and one benzylisoquinoline, (+)-reticuline, have been additionally isolated from the trunk bark of Hernandia nymphaeifolia. The structures of these compounds were elucidated by spectroscopic evidence. Six of the isolated compounds show significant cytotoxic activities (ED50 values < 1 microgram/ml) against P-388, KB16, A549, or HT-29 cell lines.
Chen
I S
IS
Graduate Institute of Pharmaceutical Sciences, Kaohsiung Medical College, Taiwan, Republic of China.
Chen
J J
JJ
Duh
C Y
CY
Tsai
I L
IL
Chang
C T
CT
D000470:Alkaloids / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology*; D001060:Aporphines; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D013056:Spectrophotometry, Ultraviolet; D014197:Trees / Q000737:chemistry*; D014407:Tumor Cells, Cultured
D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D001060:Aporphines; C081279:aporphine