title: Relationship between left ventricular diastolic function at rest and exercise capacity in patients who have suffered a previous myocardial infarction.
abstract: To assess whether left ventricular (LV) diastolic function is a determinant of exercise capacity in patients who have suffered a previous myocardial infarction (MI), we investigated the relationship between maximum exercise duration and resting LV diastolic function in 65 MI patients. Each patient underwent both a symptom-limited exercise test and LV biplane angiography with simultaneous high-fidelity pressure measurements. LV relaxation was assessed by the time constants (T1/e and T1/2) of isovolumic pressure decay, and LV diastolic distensibility was assessed by the LV end-diastolic volume (V) index-pressure (P) ratio. The time constants of relaxation did not correlate with maximum exercise capacity (r = -0.19 for T1/e, NS; r = - 0.17 for T1/2, NS). LV diastolic distensibility also did not correlate with exercise capacity (r = - 0.08, NS). These results suggest that the resting LV diastolic dysfunction is unlikely to be the principal cause of exercise intolerance in MI patients without congestive heart failure.
authors.affiliation: First Department of Internal Medicine, Mie University, Tsu, Japan.
authors.forename: C
authors.initials: C
authors.lastname: Omichi
authors.forename: T
authors.initials: T
authors.lastname: Yamakado
authors.forename: S
authors.initials: S
authors.lastname: Takebayashi
authors.forename: T
authors.initials: T
authors.lastname: Tarumi
authors.forename: E
authors.initials: E
authors.lastname: Takagi
authors.forename: T
authors.initials: T
authors.lastname: Nakano
mesh_terms: D000328:Adult; D000368:Aged; D006328:Cardiac Catheterization; D003971:Diastole; D017079:Exercise Tolerance; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000503:physiopathology*; D016277:Ventricular Function, Left