title: Ophthalmic, ultrasonographic findings in primary central nervous system lymphoma with ocular involvement.
abstract: OBJECTIVE
  To describe and classify ophthalmic, ultrasonographic findings in patients with primary central nervous system lymphoma with ocular involvement.
  
  
  METHODS
  B- and A-scan ultrasonography was performed on the eyes of 13 patients with primary central nervous system lymphoma with ocular involvement.
  
  
  RESULTS
  In seven patients, the eyes were the site of initial involvement. In the other six patients, both ocular and central nervous system disease were present at the initial evaluation. All patients had abnormal ultrasonographic findings. The most common were vitreous debris (n = 10), choroidal-scleral thickening (n = 6), and widening of the optic nerve (n = 4). Elevated chorioretinal lesions (n = 3) and retinal detachment (n = 2) were also found.
  
  
  CONCLUSIONS
  Ophthalmic ultrasonography is a useful adjunctive diagnostic technique for characterizing ocular involvement in lymphoma. Ocular lymphoma may present as chorioretinitis, vitreitis and nonspecific uveitis; it produces characteristic, but nonspecific findings on ultrasonography. The diagnosis of ocular involvement is an important factor in determining treatment.
authors.affiliation: Department of Ophthalmology, Cornell University Medical College, New York, New York 10021, USA.
authors.forename: R
authors.initials: R
authors.lastname: Ursea
authors.forename: M H
authors.initials: MH
authors.lastname: Heinemann
authors.forename: R H
authors.initials: RH
authors.lastname: Silverman
authors.forename: L M
authors.initials: LM
authors.lastname: Deangelis
authors.forename: S W
authors.initials: SW
authors.lastname: Daly
authors.forename: D J
authors.initials: DJ
authors.lastname: Coleman
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000869:Anterior Eye Segment / Q000000981:diagnostic imaging / Q000473:pathology; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001706:Biopsy; D001932:Brain Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology / Q000628:therapy; D002829:Choroid / Q000000981:diagnostic imaging / Q000473:pathology; D005134:Eye Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology / Q000628:therapy; D005260:Female; D006801:Humans; D008223:Lymphoma / Q000000981:diagnostic imaging* / Q000473:pathology / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009900:Optic Nerve / Q000000981:diagnostic imaging / Q000473:pathology; D012160:Retina / Q000000981:diagnostic imaging / Q000473:pathology; D014463:Ultrasonography; D014821:Vitrectomy; D014822:Vitreous Body / Q000000981:diagnostic imaging / Q000473:pathology