title: Effects of self-generated sad mood on regional cerebral activity: a PET study in normal subjects.
abstract: This study investigated the cerebral regions modulated by self-generated sad mood in normal subjects. Eleven healthy men experienced a temporary sad mood by recalling sad personal memories. Two control states were used for comparison: a resting condition, and a condition involving the recall of affectively neutral personal events. Regional cerebral blood flow (rCBF) images were obtained using [15O]-H2O Positron Emission Tomography. A statistical comparison of the images during negative mood and neutral recall conditions revealed that sad mood was associated with a decrease in rCBF in the left dorsolateral prefrontal, left medial prefrontal, and left temporal cortex; no increase in activity was noted in this comparison. Our results are consistent with the noted left prefrontal decrease in metabolism found in depressed patients through a variety of methodologies; however, our results contrast with findings of increased left or bilateral prefrontal activity in transient induced negative mood states reported for women (George et al., 1995, Am J Psychiatry 152:341-341) and for mixed-gender (Pardo et al., 1993, Am J Psychiatry 150:713-719) subject groups. The study brings to light a number of methodological issues, including the crucial importance of the baseline condition used for the isolation of the emotional components of a given task.
authors.affiliation: PET Centre, Clarke Institute of Psychiatry, Toronto, ON, Canada.
authors.forename: M C
authors.initials: MC
authors.lastname: Gemar
authors.forename: S
authors.initials: S
authors.lastname: Kapur
authors.forename: Z V
authors.initials: ZV
authors.lastname: Segal
authors.forename: G M
authors.initials: GM
authors.lastname: Brown
authors.forename: S
authors.initials: S
authors.lastname: Houle
mesh_terms: D000328:Adult; D000339:Affect / Q000502:physiology*; D001143:Arousal / Q000502:physiology*; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000098:blood supply*; D004292:Dominance, Cerebral / Q000502:physiology; D004734:Energy Metabolism / Q000502:physiology*; D006801:Humans; D008297:Male; D017397:Prefrontal Cortex / Q000098:blood supply; D012016:Reference Values; D012039:Regional Blood Flow / Q000502:physiology; D014055:Tomography, Emission-Computed