[Favorable effects of epsilon-aminocaproic acid on the children with nephrotic syndrome and Schonlein-Henoch syndrome treated with corticosteroids].
An effect of EACA given in the daily dose of 85-230 mg/kg for 1-1-days on the activity of certain plasma protease inhibitors in 7 children with steroid-sensitive and steroid-dependent nephrotic syndrome (age between 3.5 and 18 years), and in 6 children with Schönlein-Henoch syndrome (aged between 3.5 and 6 years). Additionally, an effect of EACA on clinical status, dynamics of improvement, proteinuria and/or erythrocyturia, and incidence of adverse reactions was studied. It was found that EACA significantly increased antithrombin III activity by approximately 68.8% proteinase alpha 1-inhibitor by 41.8% alpha 2-antiplasmin by 55% in patients with nephrotic syndrome, and increased an activity of protease alpha 1-inhibitor by 75% in patients with Schönlein-Henoch syndrome. EACA given together with corticosteroids enhanced their efficiency manifested--especially in children with Schönlein-Henoch syndrome--by a rapid diminishment of skin changes, proteinuria and erythrocyturia. A drop in blood pressure, loose stools, upper respiratory inflammation, and fever were most frequent adverse reactions. EACA given alone produced rapidly increasing edema in patients with hephrotic syndrome. It seems that EACA may be used as an adjuvant therapy in some cases of nephrotic and Schönlein-Henoch syndromse.
Prandota
J
J
Oddziału Nefrologicznego Miejskiego Szpitala Dzieciecego im. J. Korczaka we Wrocławiu.
Panków-Prandota
L
L
Rotter
A
A
Kotecki
L
L
D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage; D015119:Aminocaproic Acid / Q000494:pharmacology / Q000627:therapeutic use*; D000990:Antithrombin III / Q000187:drug effects; D002648:Child; D002675:Child, Preschool; D003967:Diarrhea / Q000139:chemically induced; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007022:Hypotension / Q000139:chemically induced; D011695:IgA Vasculitis / Q000097:blood / Q000188:drug therapy*; D008297:Male; D009404:Nephrotic Syndrome / Q000097:blood / Q000188:drug therapy*; D011480:Protease Inhibitors / Q000097:blood
D000305:Adrenal Cortex Hormones; D011480:Protease Inhibitors; D000990:Antithrombin III; D015119:Aminocaproic Acid
Korzystny wpływ kwasu epsilon-aminokapronowego u dzieci chorych na zespół nerczycowy i zespół Schönleina-Henocha leczonych kortykosteroidami.