Bacterial phospholipases and their role in virulence.
Virulence of many bacterial pathogens is based, at least in part, on the action of phospholipases. The consequences may be immediate and direct, as in the action of Clostridium perfringens alpha toxin on red cells or platelets, or subtle, as with phosphatidylinositol-specific phospholipases of Listeria monocytogenes and other bacteria.
Songer
J G
JG
Dept of Veterinary Science, University of Arizona, Tucson 85721, USA. gsonger@ccit.arizona.edu
D000818:Animals; D001419:Bacteria / Q000472:pathogenicity*; D001424:Bacterial Infections / Q000382:microbiology; D018407:Bacterial Physiological Phenomena; D001426:Bacterial Proteins / Q000502:physiology*; D001427:Bacterial Toxins / Q000378:metabolism; D002135:Calcium-Binding Proteins; D003016:Clostridium perfringens / Q000201:enzymology / Q000472:pathogenicity; D016925:Corynebacterium pseudotuberculosis / Q000201:enzymology / Q000472:pathogenicity; D006801:Humans; D008089:Listeria monocytogenes / Q000201:enzymology / Q000472:pathogenicity; D043265:Phosphatidylinositol Diacylglycerol-Lyase; D010740:Phospholipases / Q000502:physiology*; D011550:Pseudomonas aeruginosa / Q000201:enzymology / Q000472:pathogenicity; D010738:Type C Phospholipases / Q000378:metabolism; D014774:Virulence
D001426:Bacterial Proteins; D001427:Bacterial Toxins; D002135:Calcium-Binding Proteins; D010740:Phospholipases; D010738:Type C Phospholipases; C040649:alpha toxin, Clostridium perfringens; D043265:Phosphatidylinositol Diacylglycerol-Lyase