title: HIV vaccines: problems and prospects.
abstract: Several lines of evidence now argue strongly that a successful HIV vaccine does not need to block infection completely. It has to mimic what already occurs in a minority of unvaccinated individuals--namely, rapid clearance of infection or reduction of viral load to a level that does not produce symptoms or permit transmission to others. The various vaccine candidates are reviewed.
authors.affiliation: International AIDS Vaccine Initiative, Washington, DC, USA.
authors.forename: M I
authors.initials: MI
authors.lastname: Johnston
mesh_terms: D016915:AIDS Vaccines / Q000276:immunology; D000818:Animals; D015195:Drug Design; D015497:HIV-1 / Q000145:classification / Q000235:genetics / Q000276:immunology*; D006801:Humans; D015302:Simian Immunodeficiency Virus / Q000276:immunology
chemical_list: D016915:AIDS Vaccines