HLA phenotypes in healthy aged subjects.
One hundred and seventy-one unrelated elderly healthy subjects selected according to the Senieur protocol (57 men and 114 women), aged 75-104 years, and 405 healthy individuals (238 men and 167 women), aged 18-65 years, were typed for HLA-A, HLA-B, and HLA-DR antigens. The purpose of the study was to investigate a possible association between HLA antigens and longevity. In the total group of elderly, an increased frequency of HLA-B16 (11.11 vs. 5.43%) and HLA-DR7 (38.33 vs. 15.67%) and a decreased frequency of HLA-B15 (1.75 vs. 5.18%) and HLA-DR4 (11.66 vs. 24.15%) were observed. The HLA-B15DR4 haplotype was not represented (vs. 2.1%), HLA-A1B8 was found with a low frequency (2.9 vs. 4.4%), and HLA-B8DR3 was very rarely found (1.6 vs. 10.1%), whereas the HLA-B13DR7 haplotype was observed with an increased frequency (6.6 vs. 3.3%). These results are in agreement with other published data and suggest that longevity in humans may be influenced by the genetic background.
Papasteriades
C
C
Department of Immunology and Histocompatibility, Evangelismos Hospital, Athens, Greece.
Boki
K
K
Pappa
H
H
Aedonopoulos
S
S
Papasteriadis
E
E
Economidou
J
J
D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000235:genetics*; D005260:Female; D006115:Greece; D006680:HLA Antigens / Q000032:analysis / Q000096:biosynthesis / Q000235:genetics*; D015235:HLA-B Antigens / Q000032:analysis / Q000096:biosynthesis / Q000235:genetics; D059910:HLA-B15 Antigen; D015795:HLA-B8 Antigen / Q000032:analysis / Q000096:biosynthesis; D015803:HLA-DR3 Antigen / Q000032:analysis / Q000096:biosynthesis; D015804:HLA-DR4 Antigen / Q000032:analysis / Q000096:biosynthesis; D015809:HLA-DR7 Antigen / Q000032:analysis / Q000096:biosynthesis; D006801:Humans; D008136:Longevity / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D012016:Reference Values
D006680:HLA Antigens; D015235:HLA-B Antigens; C035015:HLA-B12 antigen; D059910:HLA-B15 Antigen; C049278:HLA-B16 antigen; D015795:HLA-B8 Antigen; D015803:HLA-DR3 Antigen; D015804:HLA-DR4 Antigen; D015809:HLA-DR7 Antigen