title: The atrial natriuretic peptide gene and essential hypertension in African-Caribbeans from St Vincent and the Grenadines.
abstract: Atrial natriuretic peptide (ANP) which alters sodium balance, blood volume and vascular tone represents an important candidate for investigating the genetic basis of essential hypertension (EH). Accordingly, we have studied Bgl1 and Xho1 restriction fragment length polymorphisms (RFLPs) of the ANP gene in 147 hypertensive, 141 normotensive and 67 population-based control subjects from a homogenous population of West African origin from St Vincent and the Grenadines. We found no association of either Bgl1 and Xho1 RFLPs with EH. This study suggests that the ANP locus may not exert a major gene effect on EH amongst the black people of St Vincent and the Grenadines.
authors.affiliation: Department of Clinical Pharmacology, St Bartholomew's Hospital, London, UK.
authors.forename: H I
authors.initials: HI
authors.lastname: Daniel
authors.forename: P B
authors.initials: PB
authors.lastname: Munroe
authors.forename: S M
authors.initials: SM
authors.lastname: Kamdar
authors.forename: M
authors.initials: M
authors.lastname: Lawson
authors.forename: P
authors.initials: P
authors.lastname: Lavender
authors.forename: P
authors.initials: P
authors.lastname: Forgaty
authors.forename: M J
authors.initials: MJ
authors.lastname: Caulfield
mesh_terms: D000328:Adult; D000368:Aged; D009320:Atrial Natriuretic Factor / Q000235:genetics*; D044383:Black People; D005260:Female; D006801:Humans; D006973:Hypertension / Q000208:ethnology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D019436:Saint Vincent and the Grenadines / Q000208:ethnology
chemical_list: D009320:Atrial Natriuretic Factor