title: Below-knee bypass using fresh arterial allografts for limb salvage: early results.
abstract: The purpose of this study was to evaluate early results of below-knee bypass using fresh arterial allografts as arterial substitutes for limb salvage. From April 1991 to September 1993, we performed 28 below-knee bypass procedures using fresh arterial allografts in patients without a suitable autologous vein. Allografts were obtained by multiorgan harvesting from brain-dead subjects and preserved at 4 degrees C. Histologic examination of grafts was carried out. Secondary patency at 2 years calculated using the Kaplan-Meier method was 64% (confidence interval [CI] 45%-79%). No signs of graft deterioration or rejection were noted. These preliminary results are encouraging but long-term assessment is needed before expanding the range of application.
authors.affiliation: Service de Chirurgie Vasculaire, University Hospital, Grenoble, France.
authors.forename: J L
authors.initials: JL
authors.lastname: Magne
authors.forename: I
authors.initials: I
authors.lastname: Farah
authors.forename: J J
authors.initials: JJ
authors.lastname: Roux
authors.forename: L
authors.initials: L
authors.lastname: Voirin
authors.forename: A
authors.initials: A
authors.lastname: Badra
authors.forename: M
authors.initials: M
authors.lastname: Durand
authors.forename: B
authors.initials: B
authors.lastname: Chichignoud
authors.forename: H
authors.initials: H
authors.lastname: Guidicelli
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000671:Amputation, Surgical; D000792:Angiography; D001158:Arteries / Q000637:transplantation*; D005260:Female; D005263:Femoral Artery / Q000473:pathology / Q000601:surgery; D005500:Follow-Up Studies; D006801:Humans; D007866:Leg / Q000098:blood supply* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D012086:Reoperation; D013927:Thrombosis / Q000209:etiology / Q000473:pathology; D014184:Transplantation, Homologous; D014654:Vascular Patency