title: [123I-alpha-methyltyrosine scintigraphy in malignant melanoma].
abstract: OBJECTIVE
  The aim of the study was to evaluate the ranking of the scintigraphy with L-3-123I-alpha-methyltyrosine (123I-AMT) in metastasized melanoma.
  
  
  METHODS
  26 metastases and one primary tumor of a malignant melanoma in six patients were examined with 123I-AMT whole-body scintigraphy and SPECT. Positron Emission Tomography with 2-18F-fluoro-2-desoxy-D-glucose (18F-FDG) was used as the golden standard.
  
  
  RESULTS
  With 123I-AMT-SPECT 8/10 metastases in the thorax > 1.6 cm were detected (ratio T/NT 1.2-1.8), metastases < 1.6 cm were not detectable with SPECT. In 123I-AMT whole-body scintigraphy not one lesion showed a positive tumor uptake.
  
  
  CONCLUSIONS
  In single cases 123I-AMT scintigraphy can be helpful in staging of malignant melanoma.
authors.affiliation: Departement Medizinische Radiologie, Klinik für Nuklearmedizin, Universitätsspital Zürich, Schweiz.
authors.forename: H
authors.initials: H
authors.lastname: Steinert
authors.forename: R
authors.initials: R
authors.lastname: Böni
authors.forename: R A
authors.initials: RA
authors.lastname: Huch-Böni
authors.forename: R
authors.initials: R
authors.lastname: Capaul
authors.forename: G K
authors.initials: GK
authors.lastname: von Schulthess
authors.forename: G
authors.initials: G
authors.lastname: Westera
mesh_terms: D000328:Adult; D000368:Aged; D003847:Deoxyglucose / Q000031:analogs & derivatives; D005260:Female; D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D006801:Humans; D007457:Iodine Radioisotopes; D008297:Male; D008545:Melanoma / Q000000981:diagnostic imaging* / Q000473:pathology; D008781:Methyltyrosines; D008875:Middle Aged; D009362:Neoplasm Metastasis; D013899:Thoracic Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary; D014055:Tomography, Emission-Computed; D015899:Tomography, Emission-Computed, Single-Photon; D019805:alpha-Methyltyrosine
chemical_list: D005462:Fluorine Radioisotopes; D007457:Iodine Radioisotopes; D008781:Methyltyrosines; D019788:Fluorodeoxyglucose F18; D019805:alpha-Methyltyrosine; D003847:Deoxyglucose
vernacular_title: 123I-alpha-Methyltyrosin-Szintigraphie beim malignen Melanom.