Transient suppression of macrophage functions by liposome-encapsulated drugs.
Macrophages play an important role in host defense reactions, for example, by phagocytosis of particulate materials. This process also results in the rapid removal of targeting devices such as liposomes and adenovirus vectors and of non-autologous grafted cells and materials. Another aspect of macrophage function is their production and secretion of proinflammatory cytokines. Transient and organ-specific suppression of macrophage function by liposome-mediated manipulation has been shown to improve the efficacy of drug and gene targeting and to reduce the symptoms of inflammatory reactions.
van Rooijen
N
N
Department of Cell Biology and Immunology, Faculty of Medicine, Vrije Universiteit, Amsterdam, The Netherlands. N.van_Rooijen.cell@med.vu.nl
Bakker
J
J
Sanders
A
A
D000818:Animals; D001709:Biotechnology; D004337:Drug Carriers; D018014:Gene Transfer Techniques; D006085:Graft Survival; D006801:Humans; D066298:In Vitro Techniques; D007249:Inflammation / Q000503:physiopathology; D008081:Liposomes; D008264:Macrophages / Q000187:drug effects* / Q000502:physiology*; D051379:Mice; D009928:Organ Specificity
D004337:Drug Carriers; D008081:Liposomes