[Selective increase of gamma delta T lymphocytes in peripheral blood of patients with pulmonary tuberculosis according to the kind and stage of disease].
The aim of this study was to evaluate the distribution of gamma tau T cells expressing gd T cell receptor (TCR) in the peripheral blood of 42 patients with pulmonary tuberculosis before, and during the treatment. Control groups were 15 healthy individuals and 17 patients with non granulomatous diseases. In these groups number of g/d T cells were 240 and 239 cells/ml and percentage 9.8 and 12.3, respectively. Using direct immunofluorescence with the anti-gamma delta TCR monoclonal antibodies followed by microscopy analysis, the total number and the percentage of gamma delta T cells in purified peripheral blood mononuclear cells (PBMC) was analyzed. Expression of CD4, was determined. The observation period amounted to 12 weeks of the initial treatment. The total number of gamma delta TCR in blood of tuberculous patients was 704 cells/ml and 40% respectively, and normalized during the treatment. An inverse correlation was found with the proportion of CD4+ cells in blood.
Mróz
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RM
Kliniki Chorób Płuc i Gruźlicy, Akademii Medycznej w Białymstoku.
Kowal
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Ossolińska
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M
D000328:Adult; D000704:Analysis of Variance; D018791:CD4 Lymphocyte Count; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D008297:Male; D008875:Middle Aged; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*; D014397:Tuberculosis, Pulmonary / Q000145:classification / Q000276:immunology*
D016692:Receptors, Antigen, T-Cell, gamma-delta
Wybiórczy wzrost liczby limfocytów gamma delta T we krwi obwodowej chorych na gruźlice płuc w róznej postaci i fazie choroby.