title: Capillary electrophoresis in pharmaceutical analysis.
abstract: Capillary electrophoresis (CE) is a separation technique particularly suited to the analysis of pharmaceutical compounds. This review offers a detailed discussion of the four common modes of detection coupled to CE-UV absorption, fluorescence, electrochemical, and mass spectrometry-and gives examples of the use of these methods in pharmaceutical analyses. Sample preparation and pretreatment techniques used for CE separations are described, as well as methods of preconcentration including hydrophobic retention, affinity concentration, sample stacking, and isotachophoresis. The use of affinity CE, chiral CE, and capillary gel electrophoresis for analysis of pharmaceuticals is covered in detail, and recent advances in capillary electrochromatography and CE on a chip are also discussed.
authors.affiliation: Department of Pharmaceutical Chemistry, University of Kansas, Lawrence 66047, USA.
authors.forename: L A
authors.initials: LA
authors.lastname: Holland
authors.forename: N P
authors.initials: NP
authors.lastname: Chetwyn
authors.forename: M D
authors.initials: MD
authors.lastname: Perkins
authors.forename: S M
authors.initials: SM
authors.lastname: Lunte
mesh_terms: D019075:Electrophoresis, Capillary; D004364:Pharmaceutical Preparations / Q000032:analysis* / Q000302:isolation & purification; D013057:Spectrum Analysis
chemical_list: D004364:Pharmaceutical Preparations