title: Specific protein recognition of an mRNA cap through its alkylated base.
abstract: The specific binding of N7-methylguanine cap analogues to the RNA methyltransferase VP39 was observed through X-ray crystallography, providing a prototypical structure for a complex between a protein and an mRNA 5' cap.
authors.forename: A E
authors.initials: AE
authors.lastname: Hodel
authors.forename: P D
authors.initials: PD
authors.lastname: Gershon
authors.forename: X
authors.initials: X
authors.lastname: Shi
authors.forename: S M
authors.initials: SM
authors.lastname: Wang
authors.forename: F A
authors.initials: FA
authors.lastname: Quiocho
mesh_terms: D000478:Alkylation; D001665:Binding Sites; D018360:Crystallography, X-Ray; D008780:Methyltransferases / Q000737:chemistry*; D012314:RNA Cap Analogs / Q000737:chemistry; D014764:Viral Proteins / Q000737:chemistry*
chemical_list: D012314:RNA Cap Analogs; C088682:VP39 protein, Vaccinia virus; D014764:Viral Proteins; D008780:Methyltransferases; C052744:RNA 2'-O-methyltransferase