title: Characterization of T cells transmigrating through human endothelial cells in patients with HTLV-I-associated myelopathy.
abstract: We investigated the surface markers as well as the expression of beta 2-integrin (LFA-1 beta/CD 18), in T cells migrating through human umbilical vein endothelial cells (EC) in patients with HTLV-I-associated myelopathy (HAM). No significant differences were found in the percentages of both HLA-DR+ T cells and total CD4+ cells and in the expression of beta 2-integrin between the EC-transmigrated and the EC adherent T cells. However, the percentages of HLA-DR+CD4+ cells in the transmigrated cells were significantly higher than those in the adherent cells. These results suggest that activated or HLA-DR+CD4+ T cells play an important role as the first trigger in the immunopathogenesis of HAM.
authors.affiliation: First Department of Internal Medicine, Nagasaki University School of Medicine, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Ichinose
authors.forename: T
authors.initials: T
authors.lastname: Nakamura
authors.forename: Y
authors.initials: Y
authors.lastname: Nishiura
authors.forename: A
authors.initials: A
authors.lastname: Tsujino
authors.forename: H
authors.initials: H
authors.lastname: Goto
authors.forename: S
authors.initials: S
authors.lastname: Shirabe
authors.forename: T
authors.initials: T
authors.lastname: Furuya
authors.forename: S
authors.initials: S
authors.lastname: Nagataki
mesh_terms: D000328:Adult; D000368:Aged; D018821:CD18 Antigens / Q000096:biosynthesis; D018791:CD4 Lymphocyte Count; D002465:Cell Movement / Q000276:immunology*; D002478:Cells, Cultured; D003470:Culture Media; D004730:Endothelium, Vascular / Q000166:cytology / Q000276:immunology*; D005260:Female; D006684:HLA-DR Antigens / Q000096:biosynthesis; D015368:Human T-lymphotropic virus 1; D006801:Humans; D008213:Lymphocyte Activation; D008297:Male; D008875:Middle Aged; D015493:Paraparesis, Tropical Spastic / Q000276:immunology*; D013601:T-Lymphocytes / Q000737:chemistry* / Q000378:metabolism / Q000502:physiology*; D014471:Umbilical Veins
chemical_list: D018821:CD18 Antigens; D003470:Culture Media; D006684:HLA-DR Antigens