Behavioural effects in mice of subchronic chlordiazepoxide, maprotiline, and fluvoxamine. I. Social interactions.
The present study compares the effects of subchronic administration (daily. 21 days) of chlordiazepoxide (CD), maprotiline and fluvoxamine on the behavior of male mice during dyadic social interactions. Maprotiline like chlordiazepoxide, stimulated aggression at 4 mg/kg and 2 mg/kg respectively (intermediate dose levels), whereas effects of fluvoxamine (3-8 mg/kg) were mainly sedative. Non-social activity was reduced by CD at 4 and 8 mg/kg and by maprotiline at 0.5 mg/kg. At the highest dose tested (10 mg/kg), maprotiline increased immobility, resembling the effects of fluvoxamine, while at 2 mg/kg, it reduced social investigation. Thus, despite some commonalities, there were several differences in behavioral profile of the compounds tested. Data are discussed in relation to the efficacy of each of these compounds in treating anxiety and depressive disorders.
Cutler
M G
MG
Department of Biological Sciences, Glasgow Caledonian University, UK.
Rodgers
R J
RJ
Jackson
J E
JE
D018759:Adrenergic Uptake Inhibitors / Q000494:pharmacology*; D000704:Analysis of Variance; D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D018687:Antidepressive Agents, Second-Generation / Q000494:pharmacology*; D002707:Chlordiazepoxide / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical; D016666:Fluvoxamine / Q000494:pharmacology; D008297:Male; D008376:Maprotiline / Q000494:pharmacology; D051379:Mice; D008815:Mice, Inbred Strains; D017367:Selective Serotonin Reuptake Inhibitors / Q000494:pharmacology*; D012919:Social Behavior
D018759:Adrenergic Uptake Inhibitors; D014151:Anti-Anxiety Agents; D018687:Antidepressive Agents, Second-Generation; D002707:Chlordiazepoxide; D016666:Fluvoxamine; D008376:Maprotiline; D017367:Selective Serotonin Reuptake Inhibitors