title: ATP-dependent proteases that also chaperone protein biogenesis.
abstract: The ATP-dependent proteases Clp and FtsH from bacteria, as well as mitochondrial homologs of FtsH and Lon from yeast, may act as chaperones; they mediate not only proteolysis, but also the insertion of proteins into membranes and the disassembly or oligomerization of protein complexes. The coordination of such processes with selective proteolysis may function in the quality control of protein biogenesis.
authors.affiliation: Biozentrum, University of Basel, Switzerland.
authors.forename: C K
authors.initials: CK
authors.lastname: Suzuki
authors.forename: M
authors.initials: M
authors.lastname: Rep
authors.forename: J M
authors.initials: JM
authors.lastname: van Dijl
authors.forename: K
authors.initials: K
authors.lastname: Suda
authors.forename: L A
authors.initials: LA
authors.lastname: Grivell
authors.forename: G
authors.initials: G
authors.lastname: Schatz
mesh_terms: D049069:ATP-Dependent Proteases; D000074183:ATPases Associated with Diverse Cellular Activities; D000251:Adenosine Triphosphatases / Q000235:genetics / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000378:metabolism*; D001419:Bacteria / Q000201:enzymology*; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D049071:Endopeptidase Clp; D010450:Endopeptidases / Q000378:metabolism*; D029968:Escherichia coli Proteins; D005057:Eukaryotic Cells / Q000201:enzymology*; D006360:Heat-Shock Proteins / Q000235:genetics / Q000378:metabolism; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism; D008928:Mitochondria / Q000378:metabolism; D018832:Molecular Chaperones; D008969:Molecular Sequence Data; D011506:Proteins / Q000378:metabolism*; D015800:Protozoan Proteins / Q000235:genetics / Q000378:metabolism; D012697:Serine Endopeptidases / Q000235:genetics / Q000378:metabolism
chemical_list: D001426:Bacterial Proteins; D029968:Escherichia coli Proteins; D006360:Heat-Shock Proteins; D008565:Membrane Proteins; D018832:Molecular Chaperones; D011506:Proteins; D015800:Protozoan Proteins; D000255:Adenosine Triphosphate; D010450:Endopeptidases; D049069:ATP-Dependent Proteases; C513383:FtsH protein, E coli; D012697:Serine Endopeptidases; D049071:Endopeptidase Clp; D000251:Adenosine Triphosphatases; C095049:ClpB protein, Leishmania; C088072:ClpX protein, E coli; D000074183:ATPases Associated with Diverse Cellular Activities