Antiandrogenic effect of Striga orobanchioides.
The ethanolic extract of the whole plant of Striga orobanchioides given for 7 days to immature male rats at a dose level of 200 mg/kg body weight caused a significant decrease in the weight of the testes, epididymis, seminal vesicles and the ventral prostate. It also produced degenerative changes of Leydig cells, their nucleus, the seminiferous tubules and a significant decrease in the number of spermatocytes and spermatids. The seminiferous tubules of the treated rats are shrunken and compactly arranged. The antiandrogenic or antispermatogenic effect of the extract is discussed.
Hiremath
S P
SP
Department of Chemistry, Gulbarga University, India.
Badami
S
S
Swamy
H K
HK
Patil
S B
SB
Londonkar
R L
RL
D000726:Androgen Antagonists / Q000494:pharmacology*; D000818:Animals; D005837:Genitalia, Male / Q000187:drug effects / Q000254:growth & development; D007194:India; D007985:Leydig Cells / Q000187:drug effects; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D011467:Prostate / Q000166:cytology / Q000187:drug effects / Q000254:growth & development; D051381:Rats; D017208:Rats, Wistar; D012669:Seminal Vesicles / Q000166:cytology / Q000187:drug effects / Q000254:growth & development; D013091:Spermatogenesis / Q000187:drug effects; D013737:Testis / Q000166:cytology / Q000187:drug effects / Q000254:growth & development
D000726:Androgen Antagonists; D010936:Plant Extracts