The impact of HLA-DRB1*0405 on disease severity in Korean patients with seropositive rheumatoid arthritis.
Many reports have described HLA-DRB1 genes as having an influence on disease severity and susceptibility in rheumatoid arthritis (RA). Studies were undertaken to define the effect of RA-associated alleles on disease severity in Korean patients with seropositive RA. The results indicate that the most common RA susceptibility allele, HLA-DRB1*0405, is significantly associated with bony erosion, joint deformity and extra-articular manifestations. However, RA-associated alleles in Koreans have less effect on nodular disease than in Caucasians. This suggests that the presence of RA-associated alleles, especially HLA-DRB1*0405, seems to be a prognostic marker for severe erosive disease in Koreans.
Kim
H Y
HY
Department of Internal Medicine, Rheumatism Centre of Kangnam St Mary's Hospital, Catholic University Medical College, Seoul, Korea.
Min
J K
JK
Yang
H I
HI
Park
S H
SH
Hong
Y S
YS
Jee
W H
WH
Lee
S H
SH
Cho
C S
CS
Kim
T G
TG
Han
H
H
D000328:Adult; D000483:Alleles; D001172:Arthritis, Rheumatoid / Q000453:epidemiology*; D005260:Female; D006684:HLA-DR Antigens / Q000235:genetics / Q000502:physiology*; D059811:HLA-DRB1 Chains; D006801:Humans; D007723:Korea / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index
D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains