Generalized epilepsies: emerging insights into cellular and genetic mechanisms.
In the past year we have gained significant insights into the molecular and genetic mechanisms underlying generalized absence seizures, primarily through the study of animal models. Also a new understanding has emerged about the genetic bases of certain syndromes in which generalized myoclonic and tonic-clonic seizures are expressed. New insights into these different types of generalized seizures may lead eventually to new therapies.
Hosford
D A
DA
Department of Medicine (Neurology), Duke University Medical Center, Durham, USA. dhosford@acpub.duke.edu
Caddick
S J
SJ
Lin
F H
FH
D000818:Animals; D001921:Brain / Q000002:abnormalities / Q000503:physiopathology; D004831:Epilepsies, Myoclonic / Q000235:genetics / Q000503:physiopathology; D004832:Epilepsy, Absence / Q000235:genetics / Q000503:physiopathology; D004829:Epilepsy, Generalized / Q000235:genetics* / Q000503:physiopathology; D004830:Epilepsy, Tonic-Clonic / Q000235:genetics / Q000503:physiopathology; D015870:Gene Expression / Q000502:physiology; D006801:Humans; D051379:Mice; D008967:Molecular Biology; D051381:Rats; D013577:Syndrome