Immunohistochemical studies on matrix metalloproteinase-9 (MMP-9) and type-IV collagen in endometrial carcinoma.
Immunohistochemical staining of MMP-9 and the type-IV collagen was performed on paraffin sections of endometrial carcinoma. Immunostaining in 129 cases of endometrial cancer detected MMP-9 in 19.0% of the cases. MMP-9 positive was shown in 30% of the cases with vessel invasion, and in 12.7% of the cases without vessel invasion (p < 0.05). MMP-9 showed positive in many cases with poor differentiation and lymph node metastasis, but still failed to achieve statistical significance. MMP-9 staining did not correlate with disease outcomes. We can not clarify that MMP-9 is associated with tumor-cell invasion and metastasis. Type-IV collagen deposition at the tumor-stromal border was studied in 58 cases of endometrial carcinoma in which disruptions were seen in varying degrees. The type-IV collagen in the primary lesion decreased as the differentiation decreased. Even in the lymph node metastasis lesions, the type-IV collagen was stained and was almost in agreement with the primary lesions. In the primary lesions, there was no relationship between MMP-9 staining and the type-IV collagen. It was suggested that the type-IV collagen observed in endometrial carcinoma was more concerned with the differentiation of the tumor than with the degradation by MMP-9.
Inoue
Y
Y
Department of Obstetrics and Gynecology, Kinki University School of Medicine, Osaka, Japan.
Abe
K
K
Obata
K
K
Yoshioka
T
T
Ohmura
G
G
Doh
K
K
Yamamoto
K
K
Hoshiai
H
H
Noda
K
K
D000230:Adenocarcinoma / Q000737:chemistry / Q000201:enzymology / Q000473:pathology; D003094:Collagen / Q000032:analysis*; D017364:Collagenases / Q000032:analysis*; D003593:Cytoplasm / Q000201:enzymology; D016889:Endometrial Neoplasms / Q000737:chemistry* / Q000201:enzymology / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008207:Lymphatic Metastasis; D020780:Matrix Metalloproteinase 9
D003094:Collagen; D017364:Collagenases; D020780:Matrix Metalloproteinase 9