title: Allele frequency of ADH2 and ALDH2 among Brazilians of different ethnic groups.
abstract: We determined the genotypes of the alcohol dehydrogenase (ALDH) and aldehyde dehydrogenase (ALDH2) loci of different ethnic groups living in Brazil, using saliva DNA amplified by PCR and allele-specific oligonucleotides. Self-reports of flushing reaction after drinking were also studied. The allelic frequencies of ADH2 and ALDH2 were found to be lower than those reported other authors, which might be a result of the admixture origin of the Brazilian population. Variability in facial flushing reaction suggests that other factors play a role in the expression of alcohol-induced flushing.
authors.affiliation: Department of Pharmacology, Universidade Federal de Uberlandia, Minas Gerais, Brazil.
authors.forename: B R
authors.initials: BR
authors.lastname: Santos
authors.forename: M G
authors.initials: MG
authors.lastname: Monteiro
authors.forename: H R
authors.initials: HR
authors.lastname: Thomasson
mesh_terms: D000426:Alcohol Dehydrogenase / Q000235:genetics*; D000444:Aldehyde Dehydrogenase / Q000235:genetics*; D000483:Alleles; D001938:Brazil / Q000208:ethnology; D005260:Female; D006801:Humans; D008297:Male
chemical_list: D000426:Alcohol Dehydrogenase; D000444:Aldehyde Dehydrogenase