title: An analytical study, anti-inflammatory and analgesic effects of Harpagophytum procumbens and Harpagophytum zeyheri.
abstract: The iridoids of Harpagophytum procumbens and Harpagophytum zeyheri were studied by CLHP. Harpagoside is the main iridoid for both drugs whereas 8-p-coumaroylharpagide is a representative iridoid of Harpagophytum zeyheri only. The ratio harpagoside/8-p-coumaroylharpagide can be used to distinguish chemically both species. For commercial dried aqueous extracts this ratio is intermediate because they are probably prepared from a mixture of H. procumbens and H. zeyheri drugs. The aqueous extracts of both drugs show similar analgesic and anti-inflammatory properties. Harpagophytum procumbens and Harpagophytum zeyheri should be accepted as sources for the drug Harpagophyti radix.
authors.affiliation: Laboratory of Pharmacognosy, Faculty of Pharmacy, Marseille, France.
authors.forename: B
authors.initials: B
authors.lastname: Baghdikian
authors.forename: M C
authors.initials: MC
authors.lastname: Lanhers
authors.forename: J
authors.initials: J
authors.lastname: Fleurentin
authors.forename: E
authors.initials: E
authors.lastname: Ollivier
authors.forename: C
authors.initials: C
authors.lastname: Maillard
authors.forename: G
authors.initials: G
authors.lastname: Balansard
authors.forename: F
authors.initials: F
authors.lastname: Mortier
mesh_terms: D000700:Analgesics / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000494:pharmacology*; D002851:Chromatography, High Pressure Liquid; D008297:Male; D051379:Mice; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats
chemical_list: D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal