[Dynamics of ultrastructural changes in guinea pig cardiomyocytes in experimental diphtheria intoxication].
Electron microscopy of the left and right ventricles from guinea pigs was made 24, 72, and 120 hours after they were administered diphtheria toxin, 0.3 DLM/kg. The important pathogenetic mechanism responsible for dysfunction of the "diphtheritic heart" was found to be left and right ventricular cardiomyocytic lesion discordance developing in the mid-process, by causing serious intracardiac hemodynamic disorders. The lysosomal system influencing the ultrastructure of the two ventricles may exist in the heart. In diphtheritic intoxication, cardiomyocytic lysosomes exert mainly a damaging effect on their ultrastructure.
Frolov
V A
VA
Riger
P
P
Pasechnik
A V
AV
Avanesov
A M
AM
D000818:Animals; D004167:Diphtheria Toxin / Q000633:toxicity*; D006168:Guinea Pigs; D008854:Microscopy, Electron; D018487:Ventricular Dysfunction, Left / Q000139:chemically induced* / Q000473:pathology; D018497:Ventricular Dysfunction, Right / Q000139:chemically induced* / Q000473:pathology
D004167:Diphtheria Toxin
Dinamika izmeneniĭ ul'trastruktury kardiomiotsitov morskoĭ pri difteriĭnoĭ intoksikatsii v éksperimente.