title: Bilateral ureteric obstruction secondary to the prolonged use of tiaprofenic acid.
abstract: There is increasing awareness that the long-term use of the non-steroidal anti-inflammatory agent tiaprofenic acid (Surgam) is associated with a severe form of cystitis. The condition is usually reversible with complete resolution of symptoms on stopping the drug. We present a case of tiaprofenic acid-induced cystitis resulting in bilateral hydronephrosis suggesting ureteric obstruction. The previous reported cases are reviewed and the risks of delay in withdrawal of the drug and of permanent ureteric damage are discussed.
authors.affiliation: Department of Urology, Churchill Hospital, Oxford.
authors.forename: J P
authors.initials: JP
authors.lastname: Crew
authors.forename: R
authors.initials: R
authors.lastname: Donat
authors.forename: D
authors.initials: D
authors.lastname: Roskell
authors.forename: G J
authors.initials: GJ
authors.lastname: Fellows
mesh_terms: D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D002908:Chronic Disease; D003556:Cystitis / Q000139:chemically induced* / Q000150:complications; D006801:Humans; D006869:Hydronephrosis / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D011422:Propionates / Q000009:adverse effects*; D011859:Radiography; D014517:Ureteral Obstruction / Q000139:chemically induced* / Q000000981:diagnostic imaging
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D011422:Propionates; C021270:tiaprofenic acid