[The morphogenesis of the retinal neural layer and of the optic nerve in the normal white rat and under the action of large doses of x-ray irradiation during prenatal ontogeny].
Development of retina nerve layer and optic nerve were studied in 50 embryos and fetuses of albino rat in normal embryogenesis and in 55 embryos affected by large doses of X-ray irradiation (2.24 Cy) on d 10-14 of pregnancy (second critical period-a period of placentation and organogenesis). Main regularities in the development of the structures studied were demonstrated in intact fetuses. In the experiment the progeny subjected to X-ray irradiation showed basically bilateral abnormalities in development of retina nerve layer, optic nerve and its coats.
Stepanova
I P
IP
D000016:Abnormalities, Radiation-Induced / Q000196:embryology; D000818:Animals; D000831:Animals, Newborn; D004307:Dose-Response Relationship, Radiation; D005260:Female; D005865:Gestational Age; D009024:Morphogenesis / Q000528:radiation effects; D009900:Optic Nerve / Q000196:embryology* / Q000528:radiation effects*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D012016:Reference Values; D012160:Retina / Q000196:embryology* / Q000528:radiation effects*
Morfogenez nervnogo sloia setchatki glaza i zritel'nogo nerva beloĭ krysy v norme i pri deĭstvii bol'shikh doz rentgenovskogo oblucheniia v period prenatal'nogo ontogeneza.