title: [Results of use of sandostatin in pancreatoduodenal resections].
abstract: From February 1995 to July 1996 pancreato-duodenal resection has been performed in 12 patients in RCS (7 men and 5 women, mean age 53.6 years). The operation was indicated in malignant tumors of the pancreatic head, big duodenal papilla, distal part of common bile tract (9 patients); benign diseases of pancreas (3 patients). Sandostatin (0.3 mg/day for 4-7 days) was used in all cases to prevent postoperative pancreatitis and pancreato-jejuno-anastomosis incompetence. The levels of alphfa-amylase, blood glucose, leucocytes were monitored, as well as the duration of pancreato-jejuno-anastomosis drainage use, rate and seriousness of postoperative complications and duration of in-patient treatment. The results were compared to a control group, consisting of 6 men and 6 women (mean age 53.8 years) with malignant tumours of big duodenal papilla, head of the pancreas, common bile tract. The use of Sandostatin has decreased the level of alphfa-amylase in the first postoperative day to 292.8 +/- 152.2 u/l vs. 594.9 +/- 368.79 in a control group (p > 0.05), duration of the drainage use: 6.1 +/- 1.5 days vs. 12.9 +/- 7.2 days (p < 0.05). The number and rate of severity of postoperative complications were significantly less: 58.3% vs. 100%. The frequency of pancreato-jejuno-anastomosis incompetence has decreased 3 times; the rate of abdominal cavity abscesses has decreased by 30%, the number of bile tract complications has decreased too (1 vs. 2). The rates of postoperative mortality were 8.3% in both groups. The use of Sandostatin made it possible to decrease the frequency and severity of postoperative complications and decrease the duration of in-patient treatment.
authors.affiliation: Scientific Center of Surgery, Moscow.
authors.forename: O G
authors.initials: OG
authors.lastname: Skipenko
authors.forename: O V
authors.initials: OV
authors.lastname: Voskresenskii
authors.forename: L A
authors.initials: LA
authors.lastname: Shishlo
authors.forename: G A
authors.initials: GA
authors.lastname: Shatverian
authors.forename: A D
authors.initials: AD
authors.lastname: Timoshin
authors.forename: A A
authors.initials: AA
authors.lastname: Movchun
mesh_terms: D000328:Adult; D000368:Aged; D003138:Common Bile Duct Neoplasms / Q000601:surgery*; D004379:Duodenal Neoplasms / Q000201:enzymology / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006728:Hormones / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015282:Octreotide / Q000627:therapeutic use*; D010190:Pancreatic Neoplasms / Q000201:enzymology / Q000601:surgery*; D016577:Pancreaticoduodenectomy / Q000379:methods; D010193:Pancreaticojejunostomy; D011183:Postoperative Complications / Q000201:enzymology / Q000517:prevention & control*; D012189:Retrospective Studies; D016896:Treatment Outcome; D000516:alpha-Amylases / Q000097:blood
chemical_list: D006728:Hormones; D000516:alpha-Amylases; D015282:Octreotide
vernacular_title: Rezul'taty ispol'zovaniia sandostatina pri pankreatodyodenal'nykh rezektsiiakh.