title: The effect of methamphetamine on histamine release in the rat hypothalamus.
abstract: In the present study, the effect of methamphetamine (MAP) on histamine (HA) release measured by in vivo brain microdialysis in the rat hypothalamus was investigated. Administration of MAP (3 mg/kg) significantly increase HA release from 40 to 160 min after the injection. This finding suggests that a moderate dose of MAP activates the hypothalamic HA neuron system, which may be related to effects of MAP on intrinsic biological rhythms.
authors.affiliation: Department of Psychiatry, Tohoku University School of Medicine, Sendai, Japan.
authors.forename: C
authors.initials: C
authors.lastname: Ito
authors.forename: K
authors.initials: K
authors.lastname: Onodera
authors.forename: A
authors.initials: A
authors.lastname: Yamatodani
authors.forename: T
authors.initials: T
authors.lastname: Watanabe
authors.forename: M
authors.initials: M
authors.lastname: Sato
mesh_terms: D000818:Animals; D000697:Central Nervous System Stimulants / Q000494:pharmacology*; D006636:Histamine Release / Q000187:drug effects*; D007031:Hypothalamus / Q000187:drug effects*; D008297:Male; D008694:Methamphetamine / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000697:Central Nervous System Stimulants; D008694:Methamphetamine