Role of NF-kappaB in the control of apoptotic and proliferative responses in IL-2-responsive T cells.
The NF-kappaB/Rel/IkappaB family of transcription factors regulates a number of genes involved in a wide variety of biological processes. The activation of p53, c-myc and Ras genes suggests a role for NF-kappaB in cell proliferation; NF-kappaB is also important in immune and inflammatory responses. By virtue of its role in apoptosis, NF-kappaB participates in the thymus as well as in embryonic development. The NF-kappaB family of transcription factors is also involved in viral transcription, transformation and in the development of some types of human cancers. Given the pivotal role of NF-kappaB, clarification is needed of the mechanisms through which its deregulation contributes to disease. Several aspects of NF-kappaB regulation, such as phosphatase involvement, the mechanism of IkappaB ubiquitination and the regulation of nuclear translocation, remain obscure. Here, we review and discuss the function of NF-kappaB activation in IL-2-stimulation and in apoptosis induced by IL-2 deprivation in T cells.
Gómez
J
J
Department of Immunology and Oncology, Centro Nacional de Biotecnologia, Campus de Cantoblanco, E-28049 Madrid, Spain.
García-Domingo
D
D
Martínez-A
C
C
Rebollo
A
A
D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D049109:Cell Proliferation / Q000187:drug effects; D006801:Humans; D020672:I-kappa B Proteins / Q000378:metabolism; D007376:Interleukin-2 / Q000378:metabolism / Q000494:pharmacology*; D008954:Models, Biological; D016328:NF-kappa B / Q000378:metabolism / Q000502:physiology*; D015375:Receptors, Interleukin-2 / Q000378:metabolism; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism
D020672:I-kappa B Proteins; D007376:Interleukin-2; D016328:NF-kappa B; D015375:Receptors, Interleukin-2