title: In-vitro and in-vivo activities of DW-116, a new fluoroquinolone.
abstract: DW-116 is a novel fluoroquinolone that was two- to four-fold more active than rufloxacin and less active than sparfloxacin, ciprofloxacin and ofloxacin against Gram-positive bacteria in vitro. Against Gram-positive and Gram-negative bacteria, the in-vivo activity of DW-116 was similar or slightly greater than that of rufloxacin and less than that of sparfloxacin, ciprofloxacin and ofloxacin. ED50 (50% effective dose) values for DW-116 did not correlate with in-vitro MICs.
authors.affiliation: College of Pharmacy, Seoul National University, Korea.
authors.forename: K H
authors.initials: KH
authors.lastname: Choi
authors.forename: J S
authors.initials: JS
authors.lastname: Hong
authors.forename: S K
authors.initials: SK
authors.lastname: Kim
authors.forename: D K
authors.initials: DK
authors.lastname: Lee
authors.forename: S J
authors.initials: SJ
authors.lastname: Yoon
authors.forename: E C
authors.initials: EC
authors.lastname: Choi
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology; D001424:Bacterial Infections / Q000517:prevention & control*; D002939:Ciprofloxacin / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D013293:Enterococcus faecalis / Q000187:drug effects; D024841:Fluoroquinolones; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D008297:Male; D016106:Methicillin Resistance; D051379:Mice; D008813:Mice, Inbred ICR; D008826:Microbial Sensitivity Tests; D015242:Ofloxacin / Q000494:pharmacology; D010879:Piperazines / Q000494:pharmacology*; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D015363:Quinolones / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000890:Anti-Infective Agents; C097673:DW-116; D024841:Fluoroquinolones; D010879:Piperazines; D015363:Quinolones; D002939:Ciprofloxacin; D015242:Ofloxacin; C061363:sparfloxacin; C060328:rufloxacin