title: Variations in composition of cartilage from the shoulder joints of young adult dogs at risk for developing canine hip dysplasia.
abstract: OBJECTIVE
  To determine whether the composition of cartilage from the shoulder joints of dogs varied with the risk of developing canine hip dysplasia (CHD).
  
  
  METHODS
  Observational study.
  
  
  METHODS
  12 skeletally mature (approx 1 year old) Labrador Retrievers.
  
  
  METHODS
  Dogs were classified as having a low, moderate, or high risk of developing CHD on the basis of distraction indices. Cartilage was harvested from the craniolateral and weight-bearing regions of the humeral heads, and wet weight per unit area and dry, glycosaminoglycan, and fibronectin contents were determined.
  
  
  RESULTS
  Glycosaminoglycan and dry contents did not vary among risk groups. For cartilage from the craniolateral region of the humeral head, wet weight per unit area and fibronectin content increased as risk of developing CHD increased. Wet weight and fibronectin content of cartilage from the weight-bearing region of the humeral head did not vary among risk groups.
  
  
  CONCLUSIONS
  Dogs that have a high risk of developing CHD are also more likely to develop osteoarthritis of the shoulder joint. The observed increases in wet weight per unit area and fibronectin content in cartilage from the craniolateral region of the humeral head in dogs at a high risk of developing CHD may be early sings of incipient osteoarthritis.
authors.affiliation: Department of Mechanical Engineering, College of Engineering, University of Maryland, Baltimore 21250, USA.
authors.forename: T
authors.initials: T
authors.lastname: Farquhar
authors.forename: J
authors.initials: J
authors.lastname: Bertram
authors.forename: R J
authors.initials: RJ
authors.lastname: Todhunter
authors.forename: N
authors.initials: N
authors.lastname: Burton-Wurster
authors.forename: G
authors.initials: G
authors.lastname: Lust
mesh_terms: D000818:Animals; D002358:Cartilage, Articular / Q000737:chemistry / Q000473:pathology*; D004285:Dogs; D005353:Fibronectins / Q000032:analysis; D006025:Glycosaminoglycans / Q000032:analysis; D006619:Hip Dysplasia, Canine / Q000453:epidemiology / Q000473:pathology*; D006621:Hip Joint / Q000033:anatomy & histology; D007593:Joint Instability / Q000150:complications / Q000662:veterinary; D010003:Osteoarthritis / Q000453:epidemiology / Q000473:pathology / Q000662:veterinary*; D018570:Risk Assessment; D012785:Shoulder Joint
chemical_list: D005353:Fibronectins; D006025:Glycosaminoglycans