title: Treatment of dyskeratosis congenita with granulocyte colony-stimulating factor and erythropoietin.
abstract: Aplastic anaemia is both frequent and difficult to manage in patients with dyskeratosis congenita (DC). We recently treated a 23-year-old male for a year with granulocyte colony-stimulating factor (G-CSF) and erythropoietin (Ep), with an excellent neutrophil response, and a transient effect on haemoglobin levels. G-CSF alone or combined with other cytokines may provide at least a partial effect in pancytopenic patients with DC.
authors.affiliation: Department of Pediatrics, University of Texas Medical Branch, Galveston 77555-0361, USA.
authors.forename: B P
authors.initials: BP
authors.lastname: Alter
authors.forename: F H
authors.initials: FH
authors.lastname: Gardner
authors.forename: R E
authors.initials: RE
authors.lastname: Hall
mesh_terms: D000328:Adult; D000741:Anemia, Aplastic / Q000628:therapy*; D004921:Erythropoietin / Q000627:therapeutic use; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use*; D006801:Humans; D017495:Hyperpigmentation / Q000151:congenital / Q000628:therapy; D008297:Male; D009260:Nail Diseases / Q000151:congenital / Q000628:therapy*; D013577:Syndrome; D014960:X Chromosome
chemical_list: D004921:Erythropoietin; D016179:Granulocyte Colony-Stimulating Factor