Use of serum bactericidal activity in assessing previous antibiotic therapy in acute lower respiratory tract infection in children.
Bactericidal activity in sera of children with acute lower respiratory tract infection was assayed to determine its effect on the outcome of blood culture. Parental reporting of prior antibiotic therapy was also determined. 14.4% of samples without serum bactericidal activity yielded pathogens from blood culture, whereas only 2.4% of samples with serum bactericidal activity yielded pathogens. A statistically significant correlation was found between isolation of pathogens by blood culture and serum bactericidal activity. Parental reporting could not be relied upon as there was no positive correlation.
Vasudevan
G
G
Department of Pediatrics, Jawaharlal Institute of Postgraduate, Medical Education and Research, Pondicherry, India.
Kanungo
R
R
Ramesh
I
I
Nalini
P
P
Srinivasan
S
S
D000208:Acute Disease; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000097:blood / Q000188:drug therapy / Q000382:microbiology*; D002648:Child; D002675:Child, Preschool; D006760:Hospitalization; D006801:Humans; D007223:Infant; D015203:Reproducibility of Results; D012141:Respiratory Tract Infections / Q000097:blood / Q000188:drug therapy / Q000382:microbiology*; D015610:Serum Bactericidal Test / Q000592:standards*
D000900:Anti-Bacterial Agents