title: Spiral computed tomographic colonography: determination of the central axis and digital unraveling of the colon.
abstract: OBJECTIVE
  The authors developed and tested automated and semiautomated bowel-lumen tracking and colon-unraveling techniques for determining the central axis of the bowel.
  
  
  METHODS
  A computer-simulated gastrointestinal tract phantom was used to test the accuracy of an automated algorithm for central axis determination and bowel unraveling. Variations in cross-sectional features between straight and unraveled formats were compared in a canine bowel segment in vitro and a human colon in vivo by using spiral computed tomography. Three readers each performed three semiautomated evaluations.
  
  
  RESULTS
  Accuracy of the automated algorithm was confirmed by the high degree of correlation in the cross-sectional feature measurements (length error, < 1%). For the canine colon segment, accuracy of the semiautomated algorithm was confirmed by comparison with the automated tracing. For the human colon, readings were reproducible with 3.3% (+/- 1.9 standard deviation) mean variation in length.
  
  
  CONCLUSIONS
  An automated algorithm for central axis deterioration and unraveling the colon has been validated in a gastrointestinal tract phantom. A semiautomated algorithm has been shown to be reproducible and time-efficient.
authors.affiliation: Washington University School of Medicine, Mallinckrodt Institute of Radiology, St Louis, MO 63110, USA.
authors.forename: E G
authors.initials: EG
authors.lastname: McFarland
authors.forename: G
authors.initials: G
authors.lastname: Wang
authors.forename: J A
authors.initials: JA
authors.lastname: Brink
authors.forename: D M
authors.initials: DM
authors.lastname: Balfe
authors.forename: J P
authors.initials: JP
authors.lastname: Heiken
authors.forename: M W
authors.initials: MW
authors.lastname: Vannier
mesh_terms: D000465:Algorithms; D000818:Animals; D003106:Colon / Q000000981:diagnostic imaging*; D003198:Computer Simulation; D004285:Dogs; D006801:Humans; D007091:Image Processing, Computer-Assisted; D019047:Phantoms, Imaging; D014057:Tomography, X-Ray Computed / Q000379:methods*