Spatial memory in transgenic mice with impaired glucocorticoid receptor function.
Spatial learning and memory function of transgenic mice with impaired glucocorticoid receptor function was assessed in the Morris water maze and the radial arm maze. Transgenic mice took longer to find a submerged and a visual platform in the water maze task than did mice from the parent strain (B6C/3F1), although performance was improved in the visible platform condition relative to the submerged platform task. In the radial arm maze, transgenic mice made significantly more errors than B6C/3F1 mice. In both tasks, the behavioural strategies adopted by transgenic mice were non-optimal for correct performance. It is suggested that the impaired performance displayed by transgenic mice in both tests is largely attributable to these altered behavioural strategies.
Rousse
I
I
Douglas Hospital Research Center, Department of Psychiatry, McGill University, Verdun, Quebec, Canada.
Beaulieu
S
S
Rowe
W
W
Meaney
M J
MJ
Barden
N
N
Rochford
J
J
D000818:Animals; D016373:DNA, Antisense; D007030:Hypothalamo-Hypophyseal System / Q000502:physiology; D008297:Male; D018782:Maze Learning / Q000502:physiology*; D008568:Memory / Q000502:physiology*; D051379:Mice; D008815:Mice, Inbred Strains; D008822:Mice, Transgenic; D010913:Pituitary-Adrenal System / Q000502:physiology; D011930:Reaction Time; D011965:Receptors, Glucocorticoid / Q000235:genetics / Q000502:physiology*; D012016:Reference Values; D013028:Space Perception
D016373:DNA, Antisense; D011965:Receptors, Glucocorticoid