HLA-DRB1*08 influences the development of disease in Mexican Mestizo with spondyloarthropathy.
OBJECTIVE
HLA class II encoded factors may influence the phenotype of ankylosing spondylitis (AS). These include HLA DRB1*07 for peripheral arthritis, and polymorphism of the HLA-linked LMP2 locus and HLA DRB1*08 for acute anterior uveitis (AAU). We studied the relationship between DRB1*08 and disease phenotype in additional populations of individuals with AS.


METHODS
The patient population included 385 unrelated HLA-B27 positive individuals with AS. These included 204 Caucasians and 2 populations of Mexican Mestizo with AS: 106 with predominately adult onset disease from Guadalajara and 75 with predominately juvenile onset disease from Mexico City. The control population of 428 individuals included 210 random and 36 HLA-B27 positive unrelated Canadian Caucasians and 173 random and 9 HLA-B27 positive Mexican Mestizo from Mexico City. DRB1*08 typing was by sequence specific polymerase chain reaction.


RESULTS
A significantly higher prevalence of DRB1*08 was observed in Mexican patients with juvenile onset disease (44.9%) and especially those with undifferentiated spondyloarthropathy (55.6%) compared to normal unrelated Mexican Mestizo (25.4%) (p < 0.01 for both) and in patients with undifferentiated spondyloarthropathy versus B27 controls (11.1%) (p = 0.03), although no significant differences were observed in within patient group comparisons based on phenotypic features of disease such as AAU and age at onset. No significant relationship between DRB1*08 and disease phenotype was evident in Caucasian individuals.


CONCLUSIONS
Our data suggest DRB1*08 may influence the phenotype of spondyloarthritis in Mexican Mestizo, but do not support the view that DRB1*08 influences the development of AAU, as reported in a Japanese population.
Maksymowych
W P
WP
Department of Medicine, University of Alberta, Edmonton, Canada.
Gorodezky
C
C
Olivo
A
A
Alaez
C
C
Wong
C
C
Burgos-Vargas
R
R
Sanchez-Corona
J
J
Ramos-Remus
C
C
Russell
A S
AS
D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D000368:Aged; D002648:Child; D005260:Female; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006801:Humans; D007198:Indians, North American / Q000235:genetics; D008297:Male; D008800:Mexico; D008875:Middle Aged; D010641:Phenotype; D015995:Prevalence; D013167:Spondylitis, Ankylosing / Q000453:epidemiology / Q000235:genetics / Q000276:immunology*; D044465:White People / Q000235:genetics
D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains