Effect of mizoribine on pulmonary lesions in MRL/lpr/lpr mice.
The present study was made to investigate the effect of mizoribine (MZR), an imidazole nucleoside immunosuppressant, on pulmonary lesions and immunological mode of action of MRL/lpr/lpr mice. Four-week-old female MRL/lpr/lpr mice were injected subcutaneously with 20 mg/kg body weight of MZR every other day. For control, mice were given phosphate-buffered saline (PBS) every other day. MZR caused the delay in the histological development of peribronchial and perivascular lymphocytic infiltrations in the lungs of MRL/lpr/lpr (MRL/lpr) mice. And then, MZR suppressed the number of immunoglobulin (Ig) (IgG and IgM) secreting B cells and anti-DNA-secreting B cells in the spleen of MRL/lpr/lpr mice. The above data indicate that MZR could be useful for the treatment of pulmonary lesions associated with autoimmune disorders such as systemic lupus erythematosus (SLE).
Soga
T
T
First Department of Internal Medicine, Yokohama City University School of Medicine, Japan.
Ishigatsubo
Y
Y
Kitamura
H
H
Okubo
T
T
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D001323:Autoantibodies / Q000096:biosynthesis / Q000187:drug effects / Q000276:immunology; D001327:Autoimmune Diseases / Q000188:drug therapy; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology; D006224:Cricetinae; D005260:Female; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008168:Lung / Q000187:drug effects / Q000473:pathology; D008171:Lung Diseases / Q000188:drug therapy*; D008262:Macrophage Activation / Q000187:drug effects; D016676:Macrophages, Alveolar / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D019463:Mice, Inbred MRL lpr / Q000276:immunology*; D011507:Proteinuria / Q000517:prevention & control; D012263:Ribonucleosides / Q000627:therapeutic use*; D015996:Survival Rate
D001323:Autoantibodies; D007166:Immunosuppressive Agents; D012263:Ribonucleosides; C010052:mizoribine