[Activated protein C resistance in patients with venous leg ulcer].
Patients with venous leg ulcers often show evidence of previous deep venous thrombosis. Resistance to activated protein C (APC-resistance) is an autosomal dominant inherited defect in the anticoagulant system which is a significant risk factor for development of venous thrombosis. APC-resistance was determined in plasma samples obtained from 46 unselected, consecutively admitted patients with venous leg ulcers, included during a six-month period. Twelve of the 46 patients (26%) (95% confidence limits: 14%-41%) had APC-resistance. APC-resistance is thus a common anticoagulant deficiency among venous leg ulcer patients and should be considered a risk factor for development of venous leg ulcer disease.
Munkvad
S
S
H.S. Bispebjerg Hospital, dermatologisk afdeling og klinisk-biokemisk afdeling.
Jørgensen
M
M
D000368:Aged; D003430:Cross-Sectional Studies; D004351:Drug Resistance / Q000235:genetics; D005260:Female; D006801:Humans; D007871:Leg Ulcer / Q000097:blood* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D011486:Protein C / Q000235:genetics; D020151:Protein C Deficiency; D012307:Risk Factors; D013924:Thrombophlebitis / Q000097:blood* / Q000209:etiology
D011486:Protein C
Aktiveret protein C-resistens hos patienter med venøst ulcus cruris.