title: RNA polymerase II holoenzyme and transcriptional regulation.
abstract: RNA polymerase II holoenzymes isolated from yeast and mammalian cells are large, preassembled complexes that contain some or all of the general transcription initiation factors and many other polypeptides. Recent experiments suggest that these holoenzymes may mediate alterations in chromatin structure and play a key role in regulatory mechanisms that influence transcriptional initiation, RNA chain elongation, RNA processing and transcription termination.
authors.affiliation: Banting and Best Department of Medical Research, University of Toronto, 112 College Street, Toronto, Ontario, Canada M5G 1L6. jack.greenblatt@utoronto.ca
authors.forename: J
authors.initials: J
authors.lastname: Greenblatt
mesh_terms: D000818:Animals; D002843:Chromatin / Q000502:physiology / Q000648:ultrastructure; D004268:DNA-Binding Proteins / Q000502:physiology; D005786:Gene Expression Regulation; D046911:Macromolecular Substances; D011401:Promoter Regions, Genetic; D012319:RNA Polymerase II / Q000737:chemistry / Q000502:physiology*; D012097:Repressor Proteins / Q000502:physiology; D012441:Saccharomyces cerevisiae; D014157:Transcription Factors / Q000737:chemistry / Q000502:physiology*; D014158:Transcription, Genetic
chemical_list: D002843:Chromatin; D004268:DNA-Binding Proteins; D046911:Macromolecular Substances; D012097:Repressor Proteins; D014157:Transcription Factors; D012319:RNA Polymerase II