title: Diurnal blood pressure rhythm in hypertensives with parental history of stroke.
abstract: To investigate whether the lack of nocturnal decline of blood pressure (nondipper) is a primary cause of stroke or a secondary abnormality due to stoke, we examined the relation between the blood pressure variation and parental history of stroke in 110 hypertensive patients. In nondippers (n = 54), the frequency of positive parental history of stroke was significantly higher than in dippers (n = 56) (53.7% v 33.9%, chi2 = 4.37, P = .0366). We observed a significant increase in the incidence of positive parental history of stroke in nondippers, suggesting that some genetic factors may regulate blood pressure profiles before stroke develops.
authors.affiliation: Department of Cardiology, Jichi Medical School, Minamikawachi, Tochigi, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Maeda
authors.forename: U
authors.initials: U
authors.lastname: Ikeda
authors.forename: H
authors.initials: H
authors.lastname: Ebata
authors.forename: Y
authors.initials: Y
authors.lastname: Hojo
authors.forename: H
authors.initials: H
authors.lastname: Nakagami
authors.forename: K
authors.initials: K
authors.lastname: Shimada
mesh_terms: D000368:Aged; D001794:Blood Pressure / Q000235:genetics*; D002561:Cerebrovascular Disorders / Q000235:genetics*; D002940:Circadian Rhythm; D005192:Family Health; D005260:Female; D006801:Humans; D006973:Hypertension / Q000235:genetics* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged