title: Pathogenesis of endometriosis.
abstract: This article reviews the pathogenesis of endometriosis, which involves retrograde dissemination of endometrium and/or development in situ by metaplasia, and there is evidence suggesting that genetic and hormonal factors may play a role. There is also substantial evidence that immunologic factors, namely peritoneal macrophages, T cells, natural killer cells, and soluble products secreted by these cells, are involved in the pathogenesis of endometriosis.
authors.affiliation: Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut, USA.
authors.forename: E
authors.initials: E
authors.lastname: Oral
authors.forename: A
authors.initials: A
authors.lastname: Arici
mesh_terms: D000917:Antibody Formation; D001202:Ascitic Fluid / Q000276:immunology; D004715:Endometriosis / Q000209:etiology* / Q000235:genetics / Q000276:immunology; D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D016023:Integrins / Q000502:physiology; D008598:Menstruation; D012307:Risk Factors
chemical_list: D016023:Integrins