title: Association of polymorphisms of dopamine D2 receptor (DRD2), and dopamine transporter (DAT1) genes with schizoid/avoidant behaviors (SAB).
abstract: The dopaminergic system, and in particular the dopamine D2 receptor, has been implicated in reward mechanisms in the brain. Dysfunction of the D2 dopamine receptors leads to aberrant substance-seeking behaviors (ethanol, drugs, tobacco, and food) and other related behaviors (pathological gambling, Tourette's disorder, attention-deficit/hyperactivity disorder). This is the first study supporting a strong association between the dopamine D2 receptor Taq A1 allele with schizoid/avoidant behavior (SAB). Additionally, an albeit weaker association between the 480-bp VNTR 10/10 allele of the dopamine transporter (DAT1) gene with SAB was similarly found.
authors.affiliation: UTHSC School of Public Health at Houston, Department of Behavioral Sciences, San Antonio 78284-7976, USA.
authors.forename: K
authors.initials: K
authors.lastname: Blum
authors.forename: E R
authors.initials: ER
authors.lastname: Braverman
authors.forename: S
authors.initials: S
authors.lastname: Wu
authors.forename: J G
authors.initials: JG
authors.lastname: Cull
authors.forename: T J
authors.initials: TJ
authors.lastname: Chen
authors.forename: J
authors.initials: J
authors.lastname: Gill
authors.forename: R
authors.initials: R
authors.lastname: Wood
authors.forename: A
authors.initials: A
authors.lastname: Eisenberg
authors.forename: M
authors.initials: M
authors.lastname: Sherman
authors.forename: K R
authors.initials: KR
authors.lastname: Davis
authors.forename: D
authors.initials: D
authors.lastname: Matthews
authors.forename: L
authors.initials: L
authors.lastname: Fischer
authors.forename: N
authors.initials: N
authors.lastname: Schnautz
authors.forename: W
authors.initials: W
authors.lastname: Walsh
authors.forename: A A
authors.initials: AA
authors.lastname: Pontius
authors.forename: M
authors.initials: M
authors.lastname: Zedar
authors.forename: G
authors.initials: G
authors.lastname: Kaats
authors.forename: D E
authors.initials: DE
authors.lastname: Comings
mesh_terms: D000328:Adult; D002352:Carrier Proteins / Q000235:genetics*; D050483:Dopamine Plasma Membrane Transport Proteins; D005260:Female; D006801:Humans; D008297:Male; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D001523:Mental Disorders / Q000235:genetics*; D008875:Middle Aged; D009419:Nerve Tissue Proteins; D011110:Polymorphism, Genetic / Q000235:genetics*; D017448:Receptors, Dopamine D2 / Q000235:genetics*; D012557:Schizoid Personality Disorder / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics*
chemical_list: D002352:Carrier Proteins; D050483:Dopamine Plasma Membrane Transport Proteins; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; D017448:Receptors, Dopamine D2; C493214:SLC6A3 protein, human