title: Adhesion molecules and rejection of renal allografts.
abstract: Despite an increasing amount of immunohistochemical and molecular biology data relating to the pathogenesis of kidney transplant rejection, the pathological diagnosis of this condition still rests on routine light microscopy. The detection of changes in expression and distribution of adhesion molecules in renal allograft biopsies may open a new era of increased accuracy of rejection diagnosis. Of the various adhesion molecule reactivities, peritubular capillary VCAM-1 staining appears to be the most specific finding for chronic rejection. This same staining reaction is seen in acute rejection, but may have less specificity in that setting.
authors.affiliation: Department of Pathology, Methodist Hospital, Houston, Texas, USA.
authors.forename: K
authors.initials: K
authors.lastname: Solez
authors.forename: L C
authors.initials: LC
authors.lastname: Racusen
authors.forename: F
authors.initials: F
authors.lastname: Abdulkareem
authors.forename: E
authors.initials: E
authors.lastname: Kemeny
authors.forename: E
authors.initials: E
authors.lastname: von Willebrand
authors.forename: L D
authors.initials: LD
authors.lastname: Truong
mesh_terms: D000818:Animals; D017951:Antigen Presentation; D015815:Cell Adhesion Molecules / Q000502:physiology*; D006084:Graft Rejection; D006801:Humans; D016030:Kidney Transplantation / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D015815:Cell Adhesion Molecules