title: Use of dynamic capillaroscopy for studying cutaneous microcirculation in patients with diabetes mellitus.
abstract: To investigate the relationship between cutaneous microcirculation and retinopathy in diabetes mellitus, we studied by dynamic capillaroscopy 35 diabetes mellitus patients, including 10 patients without retinopathy, 10 patients with background retinopathy, and 15 patients with proliferative retinopathy. We found that (1) cutaneous and retinal microcirculation in diabetes mellitus in long-term diabetes mellitus, regressional rather than proliferational changes occurred in skin vasculature as compared to that in retina; (2) functional impairments of cutaneous microcirculation, that is, decreased resting capillary blood cell velocity, peak blood cell velocity, and prolonged time to peak capillary blood cell velocity by dynamic capillaroscopy, could be detected in diabetes mellitus patients without retinopathy; (3) the degree of tortouosity of capillaries, impairment in peak capillary blood cell velocity, and time to peak capillary blood cell velocity of cutaneous microcirculation were significantly correlated with the gravity of retinopathy in diabetes mellitus patients; (4) abnormal leakage of fluorescence in cutaneous microcirculation appeared in diabetes mellitus patients with or without abnormal fluorescein angiography in retina. In conclusion, dynamic capillaroscopy used in concert with ophthalmoscopy and fluorescein angiography can facilitate a comprehensive examination of vasculopathy in diabetes mellitus.
authors.affiliation: Department of Dermatology, Kaohsiung Medical College, Taiwan, Republic of China.
authors.forename: C H
authors.initials: CH
authors.lastname: Chang
authors.forename: R K
authors.initials: RK
authors.lastname: Tsai
authors.forename: W C
authors.initials: WC
authors.lastname: Wu
authors.forename: S L
authors.initials: SL
authors.lastname: Kuo
authors.forename: H S
authors.initials: HS
authors.lastname: Yu
mesh_terms: D000328:Adult; D000368:Aged; D002196:Capillaries / Q000473:pathology / Q000502:physiology; D003930:Diabetic Retinopathy / Q000473:pathology / Q000503:physiopathology*; D004058:Diffusion; D005260:Female; D006801:Humans; D008297:Male; D008833:Microcirculation / Q000473:pathology / Q000502:physiology; D008875:Middle Aged; D009262:Nails / Q000098:blood supply; D012867:Skin / Q000098:blood supply*; D012969:Sodium Fluoride / Q000493:pharmacokinetics
chemical_list: D012969:Sodium Fluoride