title: Electrode for recording direction of activation, conduction velocity, and monophasic action potential of myocardium.
abstract: Conduction velocity and recovery of excitability are central facets of reentry arrhythmias, and yet there are no satisfactory techniques for the simultaneous measurement of both from the same area of myocardium. We have developed an electrode arrangement that allows the simultaneous recording of conduction velocity, repolarization of the myocardium together with an index of dispersion, and direction of activation of the myocardium. Three silver/silver chloride electrodes were arranged in an equilateral triangle with a reference electrode at the center. From this arrangement three monophasic action potentials were recorded. From the time of arrival of the wavefront of activation at each electrode the direction of activation and conduction velocity were calculated in real time by a computer. There was a good correlation for the in vivo signals from the circular electrode and the new electrode both for conduction velocity (r = 0.99, P < 0.001) and for direction of activation (r = 0.99, P < 0.001). This new mathematical method and electrode design allows the simultaneous measurement of conduction velocity and direction and monophasic action potential, and this can give a beat-by-beat indication of wavelength and dispersion of action potential duration.
authors.affiliation: Department of Physiology, Charing Cross and Westminster Medical School, London, United Kingdom.
authors.forename: S M
authors.initials: SM
authors.lastname: Horner
authors.forename: Z
authors.initials: Z
authors.lastname: Vespalcova
authors.forename: M J
authors.initials: MJ
authors.lastname: Lab
mesh_terms: D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D004558:Electric Stimulation / Q000295:instrumentation / Q000379:methods; D004566:Electrodes; D004867:Equipment Design; D005260:Female; D006321:Heart / Q000187:drug effects / Q000502:physiology*; D006329:Heart Conduction System / Q000502:physiology*; D006339:Heart Rate; D008012:Lidocaine / Q000494:pharmacology; D008297:Male; D008955:Models, Cardiovascular; D008962:Models, Theoretical; D012044:Regression Analysis; D015203:Reproducibility of Results; D013552:Swine; D013997:Time Factors
chemical_list: D008012:Lidocaine