The outcome of in vitro fertilization and embryo transfer therapy in women with endometriosis failing to conceive after laparoscopic conservative surgery.
OBJECTIVE
To compare the outcome of in vitro fertilization and embryo transfer (IVF-ET) after laparoscopic surgery in women with endometriosis with that of patients with tubal factor infertility.


METHODS
Retrospective survey of hospital and office charts using a computerized worksheet.


METHODS
Lin-Kou medical center of Chang Gung Memorial Hospital.


METHODS
Sixty-seven women with minimal to mild or moderate to severe endometriosis. Women with tubal factor infertility without other associated disorders (60 cycles) made up the control group.


METHODS
Seventy-five consecutive cycles of IVF-ET were performed in these patients who failed to conceive after laparoscopic conservative surgery.


RESULTS
The concentration of serum estradiol on the day of human chorionic gonadotropin (hCG) injection, the day of hCG injection, clinical pregnancy rates per transfer, number of follicles larger than 14 mm, number of embryos transferred, and implantation rate were not significantly different between women with endometriosis and those with tubal factor infertility. The number of oocytes retrieved and number fertilized were decreased, and the basal level of follicle-stimulating hormone on cycle day 3 was higher in women with both degrees of endometriosis. Women in both endometriosis groups received more follicle-stimulating hormone and human menopausal gonadotropin than those with tubal factor infertility.


CONCLUSIONS
The outcome of IVF-ET in patients with endometriosis after laparoscopic surgery did not differ from that in the group with tubal factor infertility, but the former required more ampules of gonadotropin to achieve the same response. The advantages of laparoscopic surgery in women with endometriosis should be probably correlated with success of IVF-ET.
Huang
H Y
HY
Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital, Chang Gung Medical College 5, Fu-Hsing Street, Kwei-Shan, Tao-Yuan, Taiwan, Republic of China.
Lee
C L
CL
Lai
Y M
YM
Chang
M Y
MY
Chang
S Y
SY
Soong
Y K
YK
D000328:Adult; D016022:Case-Control Studies; D006063:Chorionic Gonadotropin / Q000627:therapeutic use; D003613:Danazol / Q000627:therapeutic use; D004624:Embryo Transfer; D004715:Endometriosis / Q000150:complications* / Q000601:surgery; D004965:Estrogen Antagonists / Q000627:therapeutic use; D005260:Female; D005307:Fertilization in Vitro; D005640:Follicle Stimulating Hormone / Q000627:therapeutic use; D006801:Humans; D007247:Infertility, Female / Q000209:etiology* / Q000628:therapy*; D010535:Laparoscopy; D016729:Leuprolide / Q000627:therapeutic use; D008596:Menotropins / Q000627:therapeutic use; D011247:Pregnancy; D012189:Retrospective Studies; D016896:Treatment Outcome
D006063:Chorionic Gonadotropin; D004965:Estrogen Antagonists; D008596:Menotropins; D005640:Follicle Stimulating Hormone; D016729:Leuprolide; D003613:Danazol