title: Adherence of Borrelia burgdorferi to granulocytes of different animal species.
abstract: Adherence of 4 Borrelia (B.) burgdorferi strains (z7/22, z7/27, z7/41, PBi) to polymorphonuclear granulocytes from different domestic animals (horses, cattle, sheep, dogs) was investigated. All 4 strains adhered to the granulocytes. Binding assays indicated that the adherence occurred between structures on the surface of the borreliae ("binding-sites") and on the membranes of the granulocytes ("receptors"). The "receptors" consisted of 4 fractions (A, B, C, and D) with components differing in molecular weight (MW) and binding activity for proteins on the surface of B. burgdorferi. Fraction A (MW 80000) had the highest binding activity for B. burgdorferi.
authors.affiliation: Institut für Bakteriologie und Immunologie, Justus-Liebig-Universität Giessen, Germany.
authors.forename: B
authors.initials: B
authors.lastname: Grassmann
authors.forename: P A
authors.initials: PA
authors.lastname: Kopp
authors.forename: M
authors.initials: M
authors.lastname: Schmitt
authors.forename: H
authors.initials: H
authors.lastname: Blobel
mesh_terms: D000818:Animals; D001422:Bacterial Adhesion; D015748:Borrelia burgdorferi Group / Q000187:drug effects / Q000502:physiology*; D002417:Cattle; D002478:Cells, Cultured; D003902:Detergents / Q000494:pharmacology; D004285:Dogs; D006098:Granulocytes / Q000166:cytology / Q000382:microbiology*; D006361:Heating; D006736:Horses; D006801:Humans; D017830:Octoxynol / Q000494:pharmacology; D011956:Receptors, Cell Surface / Q000378:metabolism; D012756:Sheep; D012967:Sodium Dodecyl Sulfate / Q000494:pharmacology; D014105:Tosyl Compounds / Q000494:pharmacology
chemical_list: D003902:Detergents; D011956:Receptors, Cell Surface; D014105:Tosyl Compounds; D012967:Sodium Dodecyl Sulfate; C003614:4-toluenesulfonyl fluoride; D017830:Octoxynol