[ATP-dependent glutathione conjugate export pump].
KCP4 cells are resistant to cisplatin and have a GS-X pump different from MRP. The GS-X pump was suggested to be involved in reducing the accumulation of cisplatin in KCP-4 cells. The expression of cMOAT was 4-to 6-fold higher in KCP-4 cells and two other cisplatin-resistant human cell lines. It is still not clear whether the cisplatin resistance in KCP-4 cells are attributed to cMOAT. Other members of the MRP/GS-X pump family have been reported. Amino acid sequence of EBCR of rabbit is 91% identical to that of human cMOAT. On the view of cancer chemotherapy, it is very important to understand the structure and function of GS-X pumps since they may be involved in not only drug resistance but also drug metabolism and side effects.
Furukawa
T
T
Kagoshima University, Faculty of Medicine, Institute for Cancer Research.
Chen
Z S
ZS
Akiyama
S
S
D018528:ATP-Binding Cassette Transporters / Q000235:genetics; D000255:Adenosine Triphosphate / Q000378:metabolism*; D000595:Amino Acid Sequence; D000818:Animals; D027321:Anion Transport Proteins; D002352:Carrier Proteins / Q000737:chemistry / Q000378:metabolism / Q000502:physiology; D002945:Cisplatin / Q000493:pharmacokinetics / Q000494:pharmacology; D018432:Drug Resistance, Multiple; D019008:Drug Resistance, Neoplasm; D006801:Humans; D026901:Membrane Transport Proteins; D008969:Molecular Sequence Data; D011817:Rabbits; D017386:Sequence Homology, Amino Acid; D014407:Tumor Cells, Cultured
D018528:ATP-Binding Cassette Transporters; D027321:Anion Transport Proteins; D002352:Carrier Proteins; D026901:Membrane Transport Proteins; C086860:glutathione transporter; C099627:mrp2 protein, Oryctolagus cuniculus; D000255:Adenosine Triphosphate; D002945:Cisplatin