title: [Urinary tract infections in patients with diabetes mellitus].
abstract: The urinary tract is the principal site of infection in diabetics. A changed bacterial adhesion to the uroepithelium, partly as a result of a changed and lowered Tamm Horsfall Protein, and granulocyte dysfunction, possibly as a result of an abnormal intracellular calcium metabolism, are involved in the pathogenesis of urinary tract infections in diabetics. The main risk factors for bacteriuria in female diabetics are more advanced age and more frequent sexual intercourse. Diabetic patients run an increased risk of complications of urinary tract infection. If a symptomatic infection exists, the treatment of choice is antibiotics which can reach high tissue levels. It is not clear if asymptomatic bacteriuria needs medical treatment.
authors.affiliation: Academisch Ziekenhuis, afd. Interne Geneeskunde, onderafd. Infectieziekten, Utrecht.
authors.forename: S E
authors.initials: SE
authors.lastname: Geerlings
authors.forename: D W
authors.initials: DW
authors.lastname: Erkelens
authors.forename: I M
authors.initials: IM
authors.lastname: Hoepelman
mesh_terms: D000368:Aged; D000892:Anti-Infective Agents, Urinary / Q000627:therapeutic use; D001422:Bacterial Adhesion; D001437:Bacteriuria / Q000382:microbiology; D002118:Calcium / Q000378:metabolism; D048909:Diabetes Complications; D005260:Female; D006801:Humans; D008875:Middle Aged; D009088:Mucoproteins / Q000378:metabolism; D012307:Risk Factors; D014552:Urinary Tract Infections / Q000188:drug therapy / Q000209:etiology* / Q000378:metabolism; D019459:Urothelium / Q000382:microbiology
chemical_list: D000892:Anti-Infective Agents, Urinary; D009088:Mucoproteins; D002118:Calcium
vernacular_title: Urineweginfecties bij patiënten met diabetes mellitus.