Cryptic signals and the fidelity of V(D)J joining.
V(D)J recombination is responsible for the de novo creation of antigen receptor genes in T- and B-cell precursors. To the extent that lymphopoiesis takes place throughout an animal's lifetime, recombination errors present an ongoing problem. One type of aberrant rearrangement ensues when DNA sequences resembling a V(D)J joining signal are targeted by mistake. This study investigates the type of sequence likely to be subject to mistargeting, the level of joining-signal function associated with these sequences, and the number of such cryptic joining signals in the genome.
Lewis
S M
SM
Division of Biology, California Institute of Technology, Pasadena 91125, USA. Lewis@immune.med.utoronto.ca
Agard
E
E
Suh
S
S
Czyzyk
L
L
D000818:Animals; D001665:Binding Sites; D002460:Cell Line; D015321:Gene Rearrangement / Q000235:genetics / Q000502:physiology*; D010957:Plasmids / Q000378:metabolism; D011995:Recombination, Genetic / Q000235:genetics / Q000502:physiology; D017422:Sequence Analysis, DNA