title: G-cell density in the antral mucosa: a feasibility study.
abstract: In this work a new method for gastrin-secreting cell (G-cell) density measurement was employed in order to test the hypothesis that G-cell density of the antral mucosa can be estimated with an acceptable degree of error. The zone of antral mucosa where most G-cells are located was demarcated, its area was measured and the G-cells within this area were counted. The variation in the e error of the estimate according to normal distribution theory, and the size of the sampling expected to yield G-cell density values with a given error were assessed. Our data indicate that a very large surface of the G-cell zone should be explored in order to estimate G-cell density with an acceptable degree of error. G-cell density measurement appears not to be feasible on biopsy specimens or, for routine diagnosis, on gastrectomy specimens.
authors.affiliation: Cattedra di Istituzioni di Anatomia e Istologia Patologica. Università di Genova, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Pesce
authors.forename: R
authors.initials: R
authors.lastname: Rossi
authors.forename: E
authors.initials: E
authors.lastname: Lenti
authors.forename: R
authors.initials: R
authors.lastname: Tanzi
mesh_terms: D000368:Aged; D002452:Cell Count / Q000379:methods*; D005240:Feasibility Studies; D005753:Gastric Mucosa / Q000166:cytology*; D005755:Gastrins / Q000378:metabolism; D006801:Humans; D008433:Mathematics; D011706:Pyloric Antrum / Q000166:cytology* / Q000378:metabolism; D018401:Sample Size; D013272:Stomach Diseases / Q000175:diagnosis
chemical_list: D005755:Gastrins