Comparison of somatostatin and pancreastatin on secretion of gastrin, pancreatic polypeptide, and peptide YY.
The purpose of this study was to compare the effects of pancreastatin (PST) (400 pmol/kg/hr) and somatostatin (SRIF) (400 pmol/kg/hr) on food-induced release of gastrin, pancreatic polypeptide (PP), and peptide YY (PYY) in conscious dogs. The present findings indicate that SRIF is more potent than PST on the inhibition of food-induced release of PP; that SRIF and PST do not influence food-induced release of gastrin; and that PST cannot inhibit food-induced release of PYY, whereas SRIF inhibits PYY release in a potent fashion.
Gomez
G
G
Department of Surgery, University of Texas Medical Branch, Galveston 77555, USA.
Udupi
V
V
Greeley
G H
GH
D000818:Animals; D053379:Chromogranin A; D004285:Dogs; D005260:Female; D005755:Gastrins / Q000378:metabolism*; D008297:Male; D010187:Pancreatic Hormones / Q000494:pharmacology*; D010191:Pancreatic Polypeptide / Q000378:metabolism*; D019894:Peptide YY; D010455:Peptides / Q000378:metabolism*; D019518:Postprandial Period; D012636:Secretory Rate / Q000187:drug effects; D013004:Somatostatin / Q000494:pharmacology*
D053379:Chromogranin A; D005755:Gastrins; D010187:Pancreatic Hormones; D010455:Peptides; D019894:Peptide YY; C050836:pancreastatin; D013004:Somatostatin; D010191:Pancreatic Polypeptide