title: Structure determination of yeast cofilin.
abstract: Cofilin, a ubiquitous 15,000 M(r) protein, plays a central role in regulating cytoskeletal dynamics. Cofilin binds to actin monomers and filaments, and has a pH-dependent actin severing activity. The structure will allow for a detailed analysis of cofilin function.
authors.forename: A A
authors.initials: AA
authors.lastname: Fedorov
authors.forename: P
authors.initials: P
authors.lastname: Lappalainen
authors.forename: E V
authors.initials: EV
authors.lastname: Fedorov
authors.forename: D G
authors.initials: DG
authors.lastname: Drubin
authors.forename: S C
authors.initials: SC
authors.lastname: Almo
mesh_terms: D051339:Actin Depolymerizing Factors; D000595:Amino Acid Sequence; D018360:Crystallography, X-Ray; D008840:Microfilament Proteins / Q000737:chemistry*; D008958:Models, Molecular; D008969:Molecular Sequence Data; D009419:Nerve Tissue Proteins / Q000737:chemistry*; D017433:Protein Structure, Secondary; D012441:Saccharomyces cerevisiae / Q000737:chemistry*; D017386:Sequence Homology, Amino Acid
chemical_list: D051339:Actin Depolymerizing Factors; D008840:Microfilament Proteins; D009419:Nerve Tissue Proteins