title: Oral vanadyl sulphate does not affect blood cells, viscosity or biochemistry in humans.
abstract: Vanadyl sulphate (VOSO4) is used to improve performance in weight training athletes. Concerns about its safety have arisen because vanadium compounds may cause anaemia and changes in the leukocyte system. In this study, the effects of oral VOSO4 (0.5 mg/kg/day) on haematological indices (red and white cell and platelet counts, red cell mean cell volume and haemoglobin level), blood viscosity (haematocrit, plasma viscosity and blood viscosity at 10s-1 and 100s-1 shear rates) and biochemistry (lipids and indices of liver and kidney function) were investigated in a twelve week, double blind, placebo controlled trial in 31 weight training athletes. Blood viscosity was evaluated at 0, 2, 4, 8 and 12 weeks and haematological indices and biochemistry were measured before and at the end of treatment. Both the treatment group and placebo group showed increases in haematocrit (3.3-3.6%) and blood viscosity (9-11% at 100s-1 shear; 35-38% at 10s-1 shear) but there were no significant effects of treatment. Similarly there were no treatment effects on haematological indices and biochemistry. Concerns about the adverse effects of oral vanadyl sulphate on blood are not supported by the results of this trial.
authors.affiliation: School of Pharmacy, University of Otago, Dunedin, New Zealand.
authors.forename: J P
authors.initials: JP
authors.lastname: Fawcett
authors.forename: S J
authors.initials: SJ
authors.lastname: Farquhar
authors.forename: T
authors.initials: T
authors.lastname: Thou
authors.forename: B I
authors.initials: BI
authors.lastname: Shand
mesh_terms: D000328:Adult; D001772:Blood Cell Count; D001773:Blood Cells / Q000187:drug effects*; D001774:Blood Chemical Analysis; D001794:Blood Pressure / Q000187:drug effects; D001809:Blood Viscosity / Q000187:drug effects*; D001835:Body Weight / Q000187:drug effects; D005260:Female; D006400:Hematocrit; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D017968:Vanadium Compounds / Q000008:administration & dosage / Q000494:pharmacology*; D014891:Weight Lifting
chemical_list: D007004:Hypoglycemic Agents; D017968:Vanadium Compounds; C034028:vanadyl sulfate