title: Isolation and chromosomal mapping of a novel ATP-binding cassette transporter conserved in mouse and human.
abstract: We report here on the identification and genomic mapping of a novel member of the family of the ATP-binding cassette (ABC) transporters, ABC7, conserved in mouse and in humans. The ABC7 gene encodes a protein with the typical features of half-transporters, such as those involved in translocation of antigenic peptides or in peroxisomal disorders. ABC7 shows a ubiquitous expression pattern and maps to the X chromosome both in mouse and in humans. The high sequence similarity to those of two yeast half-transporters supports once again the extreme evolutionary conservation of this family of proteins.
authors.affiliation: Centre d'Immunologie, INSERM-CNRS de Marseille Luminy, France.
authors.forename: S
authors.initials: S
authors.lastname: Savary
authors.forename: R
authors.initials: R
authors.lastname: Allikmets
authors.forename: F
authors.initials: F
authors.lastname: Denizot
authors.forename: M F
authors.initials: MF
authors.lastname: Luciani
authors.forename: M G
authors.initials: MG
authors.lastname: Mattei
authors.forename: M
authors.initials: M
authors.lastname: Dean
authors.forename: G
authors.initials: G
authors.lastname: Chimini
mesh_terms: D018528:ATP-Binding Cassette Transporters / Q000235:genetics*; D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping; D017124:Conserved Sequence; D018076:DNA, Complementary; D005260:Female; D006801:Humans; D017403:In Situ Hybridization; D051379:Mice; D008969:Molecular Sequence Data; D017386:Sequence Homology, Amino Acid; D014960:X Chromosome
chemical_list: D018528:ATP-Binding Cassette Transporters; D018076:DNA, Complementary