Carney complex: report of a kindred with predominantly cutaneous manifestations.
We report a four-generation kindred with the complex of myxomas, spotty pigmentation and endocrine overactivity. This kindred demonstrates a relatively limited phenotypic expression with predominance of cutaneous features. Male-to-male transmission confirms the autosomal dominant nature of the condition. We propose that pilonidal sinus may be an associated manifestation in this kindred.
Armstrong
D K
DK
Department of Dermatology, Royal Victoria Hospital, Belfast, Northern Ireland.
Irvine
A D
AD
Handley
J M
JM
Walsh
M Y
MY
Hadden
D R
DR
Bingham
E A
EA
D000328:Adult; D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology; D002675:Child, Preschool; D005148:Facial Dermatoses / Q000235:genetics* / Q000473:pathology; D005260:Female; D018226:Fibroadenoma / Q000235:genetics* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009386:Neoplastic Syndromes, Hereditary / Q000235:genetics* / Q000473:pathology; D010375:Pedigree; D010859:Pigmentation Disorders / Q000235:genetics* / Q000473:pathology; D013577:Syndrome