Effect of long-term implanted nerve cuff electrodes on the electrophysiological properties of human sensory nerves.
During a long-term implantation (307 days) of a tripolar split cuff electrode around the palmar digital nerve to the radial side of the left index finger, branching off the median nerve in a medullary lesioned C6 patient, the physiological state of the nerve was intensively monitored. The resulting sensory nerve action potential (SNAP) amplitude was recorded, using both near-nerve electrodes and the implanted cuff electrode. The SNAP amplitude declined within 10 days to approximately 50% of the first SNAP cuff amplitude measured on Day 2 after implantation and recovered to the initial amplitude within 3 months. The SNAP amplitude measurements made with near-nerve electrodes were consistent with the cuff results; the SNAP conduction velocity (CV) recorded by the near-nerve electrodes and the cuff electrode was constant during the whole implantation period. This is in agreement with the results from two other patients: one with a cuff implanted around the sural nerve, and the other with a cuff implanted around a branch of the tibial nerve. These results and animals studies show that the cuff electrode is an electrically stable neural-electrical transducer.
Slot
P J
PJ
Center for Sensory-Motor Interaction, Aalborg University, Denmark.
Selmar
P
P
Rasmussen
A
A
Sinkjaer
T
T
D000200:Action Potentials / Q000502:physiology; D004558:Electric Stimulation; D004567:Electrodes, Implanted; D004594:Electrophysiology; D005385:Fingers / Q000294:innervation* / Q000502:physiology; D006801:Humans; D009103:Multiple Sclerosis / Q000503:physiopathology / Q000534:rehabilitation*; D009412:Nerve Fibers / Q000502:physiology; D011826:Radial Nerve / Q000502:physiology*; D012684:Sensory Thresholds / Q000502:physiology; D013119:Spinal Cord Injuries / Q000503:physiopathology / Q000534:rehabilitation*