Adsorption of fluoxetine HCl by activated charcoal.
We studied the adsorption of fluoxetine HCl (Prozac) by Norit USP XXIII activated charcoal in vitro, in simulated gastric fluid (USP; pH 1.2), and in simulated intestinal fluid (USP; pH 7.5). The data were fitted to both Langmuir and Freundlich equations. The Langmuir Qm values (maximal adsorption capacities) for pH 1.2 and 7.5 were 0.258 and 0.330 g drug/g charcoal, respectively. These excellent capacities suggest that oral charcoal therapy would be effective for fluoxetine overdose.
Cooney
D O
DO
Department of Chemical Engineering, University of Wyoming, Laramie 82071, USA.
Thomason
R
R
D000327:Adsorption; D001826:Body Fluids / Q000737:chemistry*; D002606:Charcoal; D005473:Fluoxetine / Q000737:chemistry*; D005750:Gastric Juice / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D007422:Intestines / Q000737:chemistry*; D009994:Osmolar Concentration
D005473:Fluoxetine; D002606:Charcoal