P300-like potential disappears in rabbits with lesions in the nucleus basalis of Meynert.
The nucleus basalis of Meynert (nbM, substantia innominata) in the basal forebrain provides a single major source of cholinergic innervation for the entire cerebral cortex. We tested the effects of nbM lesions on rabbit P300-like potentials. The P300-like event-related potential (ERP) was recorded in 14 female adult white rabbits using a conventional auditory oddball paradigm. The probability of occurrence for the 2-kHz and 1-kHz stimulus tones was 90% (frequent) and 10% (rare), respectively. The nbM was destroyed bilaterally in seven rabbits referred to as the nbM (+) group. In the other seven rabbits [nbM (-) group], putamen nuclei (n=6) or amygdaloid nuclei (n=1) were destroyed bilaterally. The evoked responses were recorded before and 1 week after the destruction. In the nbM (+) group, P300 amplitude to rare stimuli significantly decreased after the lesion. In the nbM (-) group, no component of ERPs showed changes after the lesions. These results indicate that the nbM might be involved in the generation of the rabbit P300.
Wang
Y
Y
Institute of Neurological Sciences, Faculty of Medicine, Tottori University, Yonago, Japan.
Nakashima
K
K
Shiraishi
Y
Y
Kawai
Y
Y
Ohama
E
E
Takahashi
K
K
D000161:Acoustic Stimulation; D000679:Amygdala / Q000502:physiology; D000818:Animals; D002540:Cerebral Cortex / Q000502:physiology*; D005071:Evoked Potentials / Q000502:physiology*; D005260:Female; D007839:Functional Laterality; D011699:Putamen / Q000502:physiology; D011817:Rabbits; D013377:Substantia Innominata / Q000502:physiology*