Follicular cell carcinoma of the thyroid in a child after bone marrow transplantation for acute lymphoblastic leukemia.
Follicular cell carcinoma (FCC) of the thyroid is rarely found during childhood. We report a 12 1/2-year-old girl with acute lymphoblastic leukemia, who developed rapidly growing FCC of the thyroid, 3 years after bone marrow transplantation. The role of chemotherapy in the induction of such secondary tumors after transplantation is discussed, and a proposal for the approach to these patients is suggested.
Rovelli
A
A
Clinica Pediatrica dell'Università di Milano, San Gerardo Hospital, Monza, Italy.
Cohen
A
A
Uderzo
C
C
Dodero
P
P
Brisigotti
M
M
Castellani
M R
MR
Romano
C
C
D018263:Adenocarcinoma, Follicular / Q000139:chemically induced*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use; D016026:Bone Marrow Transplantation; D002648:Child; D016371:Cranial Irradiation; D003520:Cyclophosphamide / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000627:therapeutic use; D016609:Neoplasms, Second Primary / Q000139:chemically induced*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy*; D012074:Remission Induction; D013964:Thyroid Neoplasms / Q000139:chemically induced*; D019172:Transplantation Conditioning / Q000009:adverse effects*; D014750:Vincristine / Q000009:adverse effects; D014916:Whole-Body Irradiation
D007166:Immunosuppressive Agents; D014750:Vincristine; D003520:Cyclophosphamide