title: [The toxicological, hygienic and clinical aspects of the action of low levels of organic solvents].
abstract: The article presents experimental data showing that Average Shift Concentration (ASC) and Maximal Single Concentration (MSC) for some solvents (tetrachloromethane, tetrachloroethane, dimethylformamide, benzene) are expedient to be justified. Clinical and hygienic materials proved significant health parameters (nervous system, peripheral blood) and urine levels of main metabolites to depend on chlorbenzene and toluene concentrations influencing the workers. Having analyzed the results, the authors recommended following hygienic norms in the air of workplace: for chlorbenzene ASC--50 mg/cu m, MSC--100 mg/cu m; biologic MAC for urine 4-chlorcatechol--0.05 g/l; for toluene ASC--50 mg/cu m, MSC--150 mg/cu m; biologic MAC for urine hippuric acid--1.5 g/l. The article shows some features of ASC and MSC practical application.
authors.forename: I P
authors.initials: IP
authors.lastname: Ulanova
authors.forename: A I
authors.initials: AI
authors.lastname: Khalepo
authors.forename: G G
authors.initials: GG
authors.lastname: Avilova
authors.forename: N N
authors.initials: NN
authors.lastname: Molodkina
authors.forename: N S
authors.initials: NS
authors.lastname: Sorkina
authors.forename: E A
authors.initials: EA
authors.lastname: Karpukhina
authors.forename: S V
authors.initials: SV
authors.lastname: Kaiutina
authors.forename: T A
authors.initials: TA
authors.lastname: Tkacheva
mesh_terms: D000395:Air Pollutants, Occupational / Q000506:poisoning* / Q000633:toxicity*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D006801:Humans; D006920:Hygiene; D008452:Maximum Allowable Concentration; D009784:Occupational Diseases / Q000139:chemically induced* / Q000175:diagnosis; D011041:Poisoning / Q000175:diagnosis / Q000209:etiology; D051381:Rats; D012997:Solvents / Q000506:poisoning* / Q000633:toxicity*; D013997:Time Factors
chemical_list: D000395:Air Pollutants, Occupational; D012997:Solvents
vernacular_title: Toksikologicheskie, gigienicheskie i klinicheskie aspekty deĭstviia nizkikh urovneĭ organicheskikh rastvoriteleĭ.