Consequences of live poliovirus vaccine administration in chronic fatigue syndrome.
The effect of live oral polio virus vaccination on chronic fatigue syndrome (CFS) patients was examined in a double-blind study. CFS patients were allocated randomly to placebo (N = 7) or vaccine (N = 7) conditions. All controls subjects received the vaccine (9). Vaccine administration was not associated with clinical exacerbation of CFS. However, objective responses to the vaccine revealed differences between patients and controls: increased poliovirus isolation, earlier peak proliferative responses, lower T-cell subsets on certain days post vaccination and a trend for reduced gamma-interferon in the CFS-vaccine group. Polio vaccination was not found to be clinically contraindicated in CFS patients, however, there was evidence of altered immune reactivity and virus clearance.
Vedhara
K
K
Department of Medicine, University of Wales College of Medicine, Cardiff, UK. k.vedhara@bristol.ac.uk
Llewelyn
M B
MB
Fox
J D
JD
Jones
M
M
Jones
R
R
Clements
G B
GB
Wang
E C
EC
Smith
A P
AP
Borysiewicz
L K
LK
D000328:Adult; D001288:Attention; D001519:Behavior; D016207:Cytokines / Q000378:metabolism; D004311:Double-Blind Method; D015673:Fatigue Syndrome, Chronic / Q000503:physiopathology* / Q000523:psychology* / Q000821:virology; D005260:Female; D006801:Humans; D007107:Immune System / Q000503:physiopathology; D008297:Male; D011939:Mental Recall; D008875:Middle Aged; D009500:Neutralization Tests; D010865:Pilot Projects; D017955:Poliovirus / Q000276:immunology / Q000302:isolation & purification; D011055:Poliovirus Vaccine, Oral / Q000627:therapeutic use*; D011584:Psychology; D016176:T-Lymphocyte Subsets / Q000473:pathology
D016207:Cytokines; D011055:Poliovirus Vaccine, Oral