title: Michelin tire syndrome: a congenital disorder of elastic fibre formation?
abstract: We describe a 15-month-old girl with Michelin tyre syndrome. She had hirsuties and marked skin folds. Histological examination showed fragmented elastic fibres in addition to smooth muscle hamartoma. On electron microscopy, decreased deposition of elastin was observed. We speculate that elastic fibre abnormalities may account for the characteristic skin changes in the Michelin tyre syndrome.
authors.affiliation: Department of Dermatology, Gunma University School of Medicine, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Sato
authors.forename: O
authors.initials: O
authors.lastname: Ishikawa
authors.forename: Y
authors.initials: Y
authors.lastname: Miyachi
authors.forename: T
authors.initials: T
authors.lastname: Aoki
authors.forename: T
authors.initials: T
authors.lastname: Tomomasa
authors.forename: K
authors.initials: K
authors.lastname: Nagashima
mesh_terms: D003240:Connective Tissue Diseases / Q000151:congenital* / Q000378:metabolism / Q000473:pathology; D004547:Elastic Tissue / Q000002:abnormalities* / Q000473:pathology; D004549:Elastin / Q000032:analysis; D005260:Female; D006628:Hirsutism / Q000151:congenital* / Q000473:pathology; D006801:Humans; D007231:Infant, Newborn; D009130:Muscle, Smooth / Q000002:abnormalities / Q000473:pathology; D013577:Syndrome
chemical_list: D004549:Elastin