Single and repeated environmental stress: effect on plasma oxytocin, corticosterone, catecholamines, and behavior.
Rat studies were done to further characterize an environmental model of stress designated shaker stress (SS). Plasma oxytocin (OT), corticosterone (CS), norepinephrine (NE), and epinephrine (E) were measured before and after 5 or 30 min of SS applied one time or applied 10 times over a 2-week period. The major findings were partial adaptation of plasma E within 30 min of acute SS, adaptation of plasma CS baselines but not responses to chronic SS, and complete adaptation of plasma OT responses to chronic SS. Poststress behavior during chronic SS was affected in the following ways: freezing time habituated, defecation and rearings increased, and grooming and teeth chattering remained relatively constant. The results show that SS produces consistent patterns of hormonal and behavioral responses; some aspects of the patterns are similar to those elicited by other environmental stresses, whereas some aspects are unique to SS. We conclude that rats do not adapt to repeated SS but rather that most hormonal and behavioral defense mechanisms are renewable on a daily basis.
Hashiguchi
H
H
Department of Medicine, School of Medicine, University of Southern California, Los Angeles 90033, USA.
Ye
S H
SH
Morris
M
M
Alexander
N
N
D000818:Animals; D001143:Arousal / Q000502:physiology*; D001522:Behavior, Animal / Q000502:physiology*; D003345:Corticosterone / Q000097:blood*; D004837:Epinephrine / Q000097:blood*; D005239:Fear / Q000502:physiology; D006185:Habituation, Psychophysiologic / Q000502:physiology; D008297:Male; D009638:Norepinephrine / Q000097:blood*; D010121:Oxytocin / Q000097:blood*; D051381:Rats; D017208:Rats, Wistar; D013315:Stress, Psychological / Q000150:complications*
D010121:Oxytocin; D003345:Corticosterone; D009638:Norepinephrine; D004837:Epinephrine