A meta-analysis of low dose aspirin for the prevention of intrauterine growth retardation.
OBJECTIVE
To determine more precisely the effect of prophylactic low dose aspirin on intrauterine growth retardation and perinatal mortality.


METHODS
Meta-analysis of 13 published randomised clinical trials.


METHODS
We searched 18 medical databases, including MEDLINE since 1964 and EMBASE since 1974, review articles and the references from each retrieved report to identify all studies evaluating the effect of aspirin in pregnancy and including both intrauterine growth retardation and perinatal mortality as outcome measures.


RESULTS
Among 13,234 women from 13 studies between 1985 and 1994, aspirin showed a significant reduction in intrauterine growth retardation (IUGR) (OR 0.82; 95% CI 0.72-0.93; P = 0.003) and a nonsignificant reduction in perinatal mortality (OR 0.84; 95% CI 0.66-1.08; P = 0.18). Subgroup analyses revealed that aspirin was effective at lower doses between 50 and 80 mg/day (IUGR: OR 0.87; 95% CI 0.76-0.99; mortality: OR 0.90, 95% CI 0.70-1.16), but that the preventive effect was greater at higher doses between 100 and 150 mg/day (IUGR: OR 0.36, 95% CI 0.22-0.59; mortality: OR 0.40, 95% CI 0.16-0.97) and among women entered before the 17th week of gestation (IUGR: OR 0.35, 95% CI 0.21-0.58; mortality: OR 0.43, 95% CI 0.17-1.06). We did not identify any specific subgroup of women most likely to benefit from aspirin treatment.


CONCLUSIONS
The results of this meta-analysis showed that early aspirin treatment reduced the risk of intrauterine growth retardation. Low dose aspirin should not be used routinely in pregnant women until those most likely to benefit from aspirin treatment have been clearly identified.
Leitich
H
H
Department of Obstetrics and Gynaecology, University of Vienna, Austria.
Egarter
C
C
Husslein
P
P
Kaider
A
A
Schemper
M
M
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D001241:Aspirin / Q000008:administration & dosage*; D005260:Female; D005317:Fetal Growth Retardation / Q000517:prevention & control*; D006801:Humans; D007226:Infant Mortality; D007231:Infant, Newborn; D016017:Odds Ratio; D011247:Pregnancy; D011295:Prenatal Care; D016032:Randomized Controlled Trials as Topic; D012680:Sensitivity and Specificity
D000894:Anti-Inflammatory Agents, Non-Steroidal; D001241:Aspirin