Georges Brohee Prize 1996. Major cytochrome P-450 families: implications in health and liver diseases.
Cytochromes P-450 are a superfamily of hemoproteins which represent the main pathway for drug and chemical oxidation. This superfamily is divided into families, subfamilies and/or single enzymes. The majority of P-450s involved in drug metabolism appear to belong to three distinct families termed CYP1, CYP2 and CYP3. Numerous invasive and non-invasive methodologies have been developed to study these enzymes. Their activities are modulated by genetic and nongenetic factors as well as pathological conditions. In this work, the significance of genetic and nongenetic control of P-450s activities in normal subjects is described. Thereafter, the impact of P-450s on the apparition of liver diseases and the effects of liver disease on P-450s activities is emphasized. In conclusion, future perspectives on this field are presented.
Horsmans
Y
Y
Gastroenterology Department, Louvain Medical School.
D001189:Aryl Hydrocarbon Hydroxylases; D001363:Awards and Prizes; D001530:Belgium; D056486:Chemical and Drug Induced Liver Injury / Q000201:enzymology; D065731:Cytochrome P-450 CYP2C19; D019389:Cytochrome P-450 CYP2D6 / Q000502:physiology; D019392:Cytochrome P-450 CYP2E1 / Q000502:physiology; D003577:Cytochrome P-450 Enzyme System / Q000145:classification / Q000235:genetics / Q000502:physiology*; D004347:Drug Interactions; D004790:Enzyme Induction; D005762:Gastroenterology; D006801:Humans; D008099:Liver / Q000201:enzymology*; D008107:Liver Diseases / Q000201:enzymology*; D006899:Mixed Function Oxygenases / Q000502:physiology; D004364:Pharmaceutical Preparations / Q000378:metabolism; D011110:Polymorphism, Genetic
D004364:Pharmaceutical Preparations; D003577:Cytochrome P-450 Enzyme System; D006899:Mixed Function Oxygenases; D019392:Cytochrome P-450 CYP2E1; D001189:Aryl Hydrocarbon Hydroxylases; C045793:CYP2C19 protein, human; D065731:Cytochrome P-450 CYP2C19; D019389:Cytochrome P-450 CYP2D6