title: The extracellular potential of a myelinated nerve fiber in an unbounded medium and in nerve cuff models.
abstract: A model is presented for the calculation of single myelinated fiber action potentials in an unbounded homogeneous medium and in nerve cuff electrodes. The model consists of a fiber model, used to calculate the action currents at the nodes of Ranvier, and a cylindrically symmetrical volume conductor model in which the fiber's nodes are represented as point current sources. The extracellular action potentials were shown to remain unchanged if the fiber diameter and the volume conductor geometry are scaled by the same factor (principle of corresponding states), both in an unbounded homogeneous medium and in an inhomogeneous volume conductor. The influence of several cuff electrode parameters, among others, cuff length and cuff diameter, were studied, and the results were compared, where possible, with theoretical and experimental results as reported in the literature.
authors.affiliation: Center for Sensory Motor Interaction, Aalborg University, Aalborg Ost, Denmark. jjs@miba.auc.dk
authors.forename: J J
authors.initials: JJ
authors.lastname: Struijk
mesh_terms: D000200:Action Potentials; D000818:Animals; D055592:Biophysical Phenomena; D001703:Biophysics; D003470:Culture Media; D004566:Electrodes; D006801:Humans; D066298:In Vitro Techniques; D008959:Models, Neurological; D009413:Nerve Fibers, Myelinated / Q000502:physiology*; D011901:Ranvier's Nodes / Q000502:physiology
chemical_list: D003470:Culture Media