An Italian family with autosomal dominant polycystic kidney disease unlinked to either the PKD1 or PKD2 gene.
We describe a family with autosomal dominant polycystic kidney disease in which molecular typing with closely linked markers for the PKD1 and PKD2 genes indicated absence of linkage. Thus, a third still unknown locus appears likely to be involved in disease development. This is the fourth "PKD3-linked" family described to date and the first from Italy.
Turco
A E
AE
Institute of Genetics, University of Verona School of Medicine, University Hospital Polyclinic Borgo Roma, Italy.
Clementi
M
M
Rossetti
S
S
Tenconi
R
R
Pignatti
P F
PF
D000328:Adult; D002874:Chromosome Mapping; D002885:Chromosomes, Human, Pair 16; D002894:Chromosomes, Human, Pair 4; D005260:Female; D008040:Genetic Linkage; D006239:Haplotypes; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D016891:Polycystic Kidney, Autosomal Dominant / Q000453:epidemiology / Q000235:genetics*