title: Localization of Xenopus Vg1 mRNA by Vera protein and the endoplasmic reticulum.
abstract: In many organisms, pattern formation in the embryo develops from the polarized distributions of messenger RNAs (mRNAs) in the egg. In Xenopus, the mRNA encoding Vg1, a growth factor involved in mesoderm induction, is localized to the vegetal cortex of oocytes. A protein named Vera was shown to be involved in Vg1 mRNA localization. Vera cofractionates with endoplasmic reticulum (ER) membranes, and endogenous Vg1 mRNA is associated with a subcompartment of the ER. Vera may promote mRNA localization in Xenopus oocytes by mediating an interaction between the Vg1 3' untranslated region and the ER subcompartment.
authors.affiliation: Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA.
authors.forename: J O
authors.initials: JO
authors.lastname: Deshler
authors.forename: M I
authors.initials: MI
authors.lastname: Highett
authors.forename: B J
authors.initials: BJ
authors.lastname: Schnapp
mesh_terms: D000818:Animals; D001483:Base Sequence; D001692:Biological Transport; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D006023:Glycoproteins / Q000235:genetics*; D008969:Molecular Sequence Data; D009154:Mutation; D009865:Oocytes / Q000378:metabolism*; D009866:Oogenesis; D011485:Protein Binding; D011506:Proteins / Q000378:metabolism*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism*; D012091:Repetitive Sequences, Nucleic Acid; D016212:Transforming Growth Factor beta / Q000235:genetics*; D029867:Xenopus Proteins; D014982:Xenopus laevis
chemical_list: C513103:GDF1 protein, Xenopus; D006023:Glycoproteins; D011506:Proteins; D012333:RNA, Messenger; D016212:Transforming Growth Factor beta; D029867:Xenopus Proteins