Gm and Km allotypes and typhoid fever.
Gm and Km allotypes of immunoglobulins were determined in children with typhoid fever (Cases), in children without infectious diseases (Con-1), and in children with fever but no Salmonella in their blood or bone marrow (Con-2). Children were sampled from the urban population of Santiago; and they belonged to the low and low-middle socioeconomic strata. Cases had a higher frequency of [f;(-);b1,b3 or 3;(-);5,13] G1m, G2m, G3m haplotype than Con-1 and Con-2. Con-1 and Con-2 did not differ in their Gm haplotype or Km allele frequencies, but they differed in phenotype distribution. Con-1 deviated from Hardy-Weinberg equilibrium for Km due to a lack of Km 1-1 homozygotes. The relationship among these results, the ethnic origin of Chileans, and the differential susceptibility to typhoid fever are discussed.
Herrera
P
P
Departamento de Pediatría, CEC, Facultad de Medicina, Universidad de Chile, Santiago, Chile.
Arcos-Burgos
M
M
Valenzuela
C Y
CY
Pandey
J P
JP
D000293:Adolescent; D000704:Analysis of Variance; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D006801:Humans; D007126:Immunoglobulin Allotypes / Q000097:blood / Q000235:genetics*; D007129:Immunoglobulin Gm Allotypes / Q000097:blood / Q000145:classification / Q000235:genetics*; D008297:Male; D010641:Phenotype; D014435:Typhoid Fever / Q000235:genetics / Q000382:microbiology / Q000473:pathology*
D007126:Immunoglobulin Allotypes; D007129:Immunoglobulin Gm Allotypes