title: Neurodevelopmental profile of Down syndrome in Chinese children.
abstract: OBJECTIVE
  To give an overall appraisal of the clinical features of Down syndrome (DS) in Chinese children with emphasis on the neurodevelopmental outcome, and to compare the related complications with that of other races.
  
  
  METHODS
  The records of 124 Chinese children with DS assessed at the Child Assessment Centre of the University Department of Paediatrics in the Duchess of Kent Children's Hospital from 1985 to 1993 were reviewed.
  
  
  RESULTS
  Thirty-one per cent of patients had microcephaly. Eighty-five percent (33/39) when assessed in the first year of life had a developmental quotient (DQ) above 50 but only 29% (2/7) had DQ above 50 when assessed after the age of 5. Only two patients (1.6%) had epilepsy: infantile spasms (1) and Lennox-Gastaut syndrome (1). Hearing impairment was found in 45% of children with mild conductive hearing impairment being the most common.
  
  
  CONCLUSIONS
  Chinese children with DS, when compared with other races, were similarly intellectually disabled, but were less likely to develop epilepsy.
authors.affiliation: University Department of Paediatrics, Queen Mary Hospital, Hong Kong.
authors.forename: K L
authors.initials: KL
authors.lastname: Kwong
authors.forename: V
authors.initials: V
authors.lastname: Wong
mesh_terms: D000293:Adolescent; D044466:Asian People; D002648:Child; D002675:Child, Preschool; D002681:China / Q000208:ethnology; D004314:Down Syndrome / Q000150:complications* / Q000208:ethnology / Q000235:genetics; D004827:Epilepsy / Q000209:etiology*; D005260:Female; D006311:Hearing Disorders / Q000209:etiology*; D006723:Hong Kong; D006801:Humans; D007223:Infant; D008607:Intellectual Disability / Q000209:etiology*; D008297:Male; D008831:Microcephaly / Q000209:etiology*