Effect of beryllium chloride on porphyrin metabolism in pregnant mice administered by subcutaneous injection.
The effect of beryllium (Be) compounds on porphyrins was investigated in pregnant mice. The blood protoporphyrin (Proto) and zinc protoporphyrin (Zn Proto) concentrations were increased in pregnancy. Regardless of pregnancy or nonpregnancy, the Proto concentration was decreased after Be injection. Delta-aminolevulinic acid dehydratase (ALA-D) and porphobilinogen deaminase (PBG-D) activities in blood were significantly elevated in the pregnant untreated (Con-pregnant) group, compared to the nonpregnant mice untreated (Con-nonpregnant) and nonpregnant mice treated with Be (Be-nonpregnant) groups. The blood ALA-D activity of the pregnant mice treated with Be (Be-pregnant group) tended to decrease, compared to Con-pregnant group. The blood PBG-D activity in the Be-pregnant group was significantly lower compared with that of the Con-pregnant group. The ALA-D and PBG-D activities in the spleen were also significantly elevated in the Con-pregnant group, compared to nonpregnant groups. However, it was noted that these values in the Be-pregnant group were almost the same as that of the Con-nonpregnant group and were significantly lower than that in the Con-pregnant group. The elevation of ALA-D and PBG-D activities in the blood and spleen, which play a role in the hematopoietic function of mice, was observed in the Con-pregnant mice compared to the nonpregnant mice. However, the phenomenon was not observed in the Be-pregnant mice, it suggesting that Be suppressed the pregnancy-induced increase in hematopoietic function.
Sakaguchi
S
S
Kawamura Gakuen Woman's University, Chiba, Japan.
Sakaguchi
T
T
Nakamura
I
I
Aminaka
M
M
Tanaka
T
T
Kudo
Y
Y
D000818:Animals; D001608:Beryllium / Q000008:administration & dosage / Q000633:toxicity*; D001798:Blood Proteins / Q000032:analysis; D001835:Body Weight / Q000187:drug effects; D005260:Female; D006400:Hematocrit; D006410:Hematopoiesis / Q000187:drug effects; D011163:Hydroxymethylbilane Synthase / Q000097:blood / Q000378:metabolism; D007279:Injections, Subcutaneous; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009929:Organ Size / Q000187:drug effects; D000623:Porphobilinogen Synthase / Q000097:blood / Q000378:metabolism; D011166:Porphyrins / Q000378:metabolism*; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects* / Q000378:metabolism; D011524:Protoporphyrins / Q000097:blood; D013154:Spleen / Q000187:drug effects / Q000201:enzymology
D001798:Blood Proteins; D011166:Porphyrins; D011524:Protoporphyrins; C017803:zinc protoporphyrin; C032776:beryllium chloride; D011163:Hydroxymethylbilane Synthase; D000623:Porphobilinogen Synthase; D001608:Beryllium