Elevated serum angiotensin converting enzyme levels in metastatic ovarian dysgerminoma.
A case of a 32-year-old XY genotype female is described, presenting with mediastinal and abdominal lymphadenopathy and associated with an elevated serum angiotensin I converting enzyme (SACE) level. Lymph node histology showed a malignant dysgerminoma of ovarian origin. Combined chemotherapy led to a radiological regression of the lymphadenopathy and coincided with a decrease in SACE concentration. The authors suggest that SACE may be a marker for disseminated germinoma tumours and may be useful for monitoring treatment.
Cotter
T P
TP
Cork University Hospital, Ireland.
Kealy
N P
NP
Duggan
P F
PF
Curtain
A
A
Bredin
C P
CP
D000328:Adult; D014408:Biomarkers, Tumor / Q000097:blood*; D012734:Disorders of Sex Development / Q000150:complications / Q000235:genetics; D004407:Dysgerminoma / Q000201:enzymology / Q000556:secondary* / Q000628:therapy; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D010051:Ovarian Neoplasms / Q000473:pathology*; D007703:Peptidyl-Dipeptidase A / Q000097:blood*
D014408:Biomarkers, Tumor; D007703:Peptidyl-Dipeptidase A