title: Expression of the helix-loop-helix factor, Hes3, during embryo development suggests a role in early midbrain-hindbrain patterning.
abstract: The Hes gene family members are mammalian homologues of the Drosophila hairy and Enhancer of split genes. hairy and Enhancer of split function in both segmentation and in the Notch neurogenic pathway during Drosophila embryo development. Previous expression data suggested a conserved role for the Hes genes in the Notch signalling pathway, but not in segmentation. Here, Hes3 expression during mouse embryogenesis is described. During early development of the central nervous system, Hes3 is expressed specifically in the region of the midbrain/hindbrain boundary, and in rhombomeres 2, 4, 6 and 7. This pattern suggests that Hes3 may have a conserved role as a segmentation gene. Later in development, Hes3 is co-expressed with other neurogenic gene homologues in the developing central nervous system and epithelial cells undergoing mesenchyme induction.
authors.affiliation: Institute for Molecular Biology, LSB 425, McMaster University, Hamilton, ON, Canada. lobe@mcmail.cis.mcmaster.ca
authors.forename: C G
authors.initials: CG
authors.lastname: Lobe
mesh_terms: D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins; D056970:Co-Repressor Proteins; D004268:DNA-Binding Proteins / Q000378:metabolism* / Q000502:physiology; D051767:Early Growth Response Protein 2; D004475:Ectoderm / Q000378:metabolism; D005314:Embryonic and Fetal Development; D018257:Helix-Loop-Helix Motifs / Q000502:physiology; D018398:Homeodomain Proteins / Q000378:metabolism; D017403:In Situ Hybridization; D008636:Mesencephalon / Q000196:embryology / Q000378:metabolism*; D051379:Mice; D008815:Mice, Inbred Strains; D009420:Nervous System / Q000378:metabolism; D011506:Proteins / Q000378:metabolism; D051381:Rats; D012249:Rhombencephalon / Q000196:embryology / Q000378:metabolism*; D013997:Time Factors; D000072056:Transcription Factor HES-1; D014157:Transcription Factors / Q000378:metabolism
chemical_list: D051792:Basic Helix-Loop-Helix Proteins; D056970:Co-Repressor Proteins; D004268:DNA-Binding Proteins; D051767:Early Growth Response Protein 2; D018398:Homeodomain Proteins; D011506:Proteins; D000072056:Transcription Factor HES-1; D014157:Transcription Factors; C499317:Ascl1 protein, mouse; C499318:Ascl1 protein, rat; C497327:Egr2 protein, mouse; C497328:Egr2 protein, rat; C080330:En1 protein, mouse; C489734:Hes1 protein, mouse; C489735:Hes1 protein, rat; C083910:Hes3 protein, rat; C089462:Tle5 protein, mouse