title: Clinical evaluation of AK 100 ULTRA for predilution HF with on-line prepared bicarbonate substitution fluid. Comparison with HD and acetate postdilution HF.
abstract: Convective transport across dialysis membranes has been known for a long time to be a good alternative to diffusion. Predilution hemofiltration (HF) offers a better clearance of small molecules and overcomes the blood viscosity problems related to conventional postdilution HF treatment. Three patients have performed a total of 293 predilution HF treatments with AK 100 ULTRA. The bicarbonate substitution fluid has been prepared on-line by the machine. The treatments have been well tolerated and no adverse patients reactions related to the quality of the substitution fluid or the predilution HF treatment have been observed. There is a drop in creatinine for all patients indicating an improved creatinine clearance. Bicarbonate predilution HF has been shown to be a safe and efficient treatment modality, it offers the possibility to improve the cardiovascular stability of patients having problems with other treatment modalities an it offers an improved intertreatment well-being for the patients.
authors.affiliation: Department of Nephrology and Dialysis, San Gerardo Hospital, Monza, Italy.
authors.forename: D
authors.initials: D
authors.lastname: Limido
authors.forename: P
authors.initials: P
authors.lastname: Beretta
authors.forename: M R
authors.initials: MR
authors.lastname: Viganò
authors.forename: P
authors.initials: P
authors.lastname: Mariani
authors.forename: M
authors.initials: M
authors.lastname: Borström
authors.forename: B
authors.initials: B
authors.lastname: Redaelli
mesh_terms: D000368:Aged; D001772:Blood Cell Count; D001774:Blood Chemical Analysis; D001794:Blood Pressure / Q000502:physiology; D001831:Body Temperature / Q000502:physiology; D001835:Body Weight / Q000502:physiology; D002318:Cardiovascular Diseases / Q000517:prevention & control; D003404:Creatinine / Q000652:urine; D015314:Dialysis Solutions / Q000592:standards*; D005260:Female; D006339:Heart Rate / Q000502:physiology; D006440:Hemofiltration / Q000592:standards*; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008567:Membranes, Artificial; D008875:Middle Aged; D009862:Online Systems; D006435:Renal Dialysis / Q000592:standards; D016896:Treatment Outcome
chemical_list: D015314:Dialysis Solutions; D008567:Membranes, Artificial; D003404:Creatinine