title: Comparison of two regimens of feeding and oral electrolyte solutions in infants with diarrhea.
abstract: BACKGROUND
  Glucose-based oral rehydration solutions (ORS) available in the United States do not appear to reduce the severity or duration of diarrhea. The use of cereal-derived ORS and cereal-based feedings appears to diminish the severity of illness in studies conducted in the developing world. To our knowledge, no controlled trials of cereal-derived ORS or cereal-based feedings have been performed in the United States.
  
  
  METHODS
  We performed a randomized, double-blind trial of two ORS feeding regimens in outpatients with diarrhea. Patients aged 2-13 months with acute watery diarrhea were enrolled. Subjects received standard glucose-based ORS in alternation with soy-based, lactose-free infant formula (Group 1) or rice syrup solid containing ORS in alternation with rice-based, lactose-free infant formula (Group 2). Subjects were visited at home daily to determine the severity of illness and characteristics of the stool.
  
  
  RESULTS
  After the first 2 days, significantly more Group 1 subjects continued to have diarrhea than did Group 2 subjects (median duration of diarrhea 3 vs. 2 days) as demonstrated by Kaplan-Meier survival curves (p = 0.04).
  
  
  CONCLUSIONS
  We conclude that infants fed a regimen consisting of rice syrup solid containing ORS and rice formula resolved their diarrhea sooner than did infants fed a regimen of standard glucose-based ORS and formula. The relative contributions of ORS and formula to this more rapid recovery can be elucidated by further studies.
authors.affiliation: Department of Pediatrics, Johns Hopkins University, School of Medicine, Baltimore, Maryland 21287-3144, USA.
authors.forename: J G
authors.initials: JG
authors.lastname: Goepp
authors.forename: S
authors.initials: S
authors.lastname: Katz
authors.forename: E
authors.initials: E
authors.lastname: Cuervo
authors.forename: R
authors.initials: R
authors.lastname: Reid
authors.forename: J R
authors.initials: JR
authors.lastname: Moran
authors.forename: M
authors.initials: M
authors.lastname: Santosham
mesh_terms: D003968:Diarrhea, Infantile / Q000628:therapy*; D004311:Double-Blind Method; D004573:Electrolytes / Q000008:administration & dosage*; D006801:Humans; D007223:Infant; D007225:Infant Food; D012275:Oryza; D015532:Rehydration Solutions / Q000627:therapeutic use*
chemical_list: D004573:Electrolytes; D015532:Rehydration Solutions