Prevalence of phthioic acid in Aspergillus species.
We examined fast atom bombardment mass spectra (FAB-MS) of 29 clinical isolates of Aspergillus, from five pathogenic species, for the presence of phthioic acid anions (m/z 395.6) when grown at 37 degrees C. Phthioic acid was detected in only one of 12 A. fumigatus, three of nine A. terreus and one of four A. niger isolates. Phthioic acid is unlikely to be a major pathogenicity determinant of Aspergillus.
Birch
M
M
University of Manchester Department of Medicine, Hope Hospital, Salford, UK.
Drucker
D B
DB
Boote
V
V
Denning
D W
DW
D001228:Aspergillosis / Q000382:microbiology; D001230:Aspergillus / Q000737:chemistry* / Q000302:isolation & purification / Q000472:pathogenicity; D001231:Aspergillus flavus / Q000737:chemistry / Q000302:isolation & purification; D001232:Aspergillus fumigatus / Q000737:chemistry / Q000302:isolation & purification; D001234:Aspergillus niger / Q000737:chemistry / Q000302:isolation & purification; D005227:Fatty Acids / Q000032:analysis* / Q000737:chemistry; D006801:Humans; D016339:Spectrometry, Mass, Fast Atom Bombardment / Q000379:methods
D005227:Fatty Acids; C011989:phthioic acid