title: Cycloartane triterpene glycosides from the roots of Astragalus melanophrurius.
abstract: From the roots of Astragalus melanophrurius eight known saponins (1-8) were isolated. Based on spectral data (IR, 1H- and 13C-NMR, and FABMS), the structures were established as astrasieversianins II (1) and X (4), astragalosides I (2), II (3), IV (5) and VI (7), and cyclocanthosides E (6) and G (8). The isolates were evaluated in a broad range of bioassay systems and found to be inactive. Modest antibacterial activity was observed, however, as was immunomodulatory activity, as indicated by stimulation of isolated human lymphocytes.
authors.forename: I
authors.initials: I
authors.lastname: Caliş
authors.forename: A
authors.initials: A
authors.lastname: Yürüker
authors.forename: D
authors.initials: D
authors.lastname: Taşdemir
authors.forename: A D
authors.initials: AD
authors.lastname: Wright
authors.forename: O
authors.initials: O
authors.lastname: Sticher
authors.forename: Y D
authors.initials: YD
authors.lastname: Luo
authors.forename: J M
authors.initials: JM
authors.lastname: Pezzuto
mesh_terms: D000276:Adjuvants, Immunologic / Q000737:chemistry / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D018517:Plant Roots / Q000737:chemistry*; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013055:Spectrophotometry, Infrared; D014407:Tumor Cells, Cultured
chemical_list: D000276:Adjuvants, Immunologic; D000890:Anti-Infective Agents; D000972:Antineoplastic Agents, Phytogenic; D006027:Glycosides