Agranulocytosis and thrombocytopenic purpura following measles infection in a living-related orthotopic liver transplantation recipient.
Agranulocytosis and thrombocytopenic purpura occurred simultaneously following measles infection in a 2-year-old girl who had received a living-related orthotopic liver transplantation. Neutrophil and platelet counts rose to more than 0.5 x 10(3)/mm and 30 x 10(3)/mm3, respectively, 8 weeks after the onset of neutropenia and thrombocytopenia, and within 2 weeks from the start of subcutaneous injection of granulocyte colony-stimulating factor. Simultaneous occurrence of measles infection, neutropenia and thrombocytopenia has not been described before in the literature. An autoimmune mechanism was suspected because serum levels of platelet-associated immunoglobulin G (IgG) and anti-neutrophil antibody were evaluated during the acute phase.
Arakawa
Y
Y
Department of Pediatrics, Jichi Medical School, Tochigi, Japan.
Matsui
A
A
Sasaki
N
N
Nakayama
T
T
D000380:Agranulocytosis / Q000209:etiology* / Q000276:immunology; D002675:Child, Preschool; D005260:Female; D006801:Humans; D016867:Immunocompromised Host; D008105:Liver Cirrhosis, Biliary / Q000601:surgery; D016031:Liver Transplantation / Q000276:immunology*; D019520:Living Donors; D008457:Measles / Q000150:complications* / Q000276:immunology; D008459:Measles virus / Q000302:isolation & purification; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000209:etiology* / Q000276:immunology