Creutzfeldt-Jakob disease with features of obsessive-compulsive disorder and anorexia nervosa: the role of cortical-subcortical systems.
The authors examined the clinical and neuropathological characteristics of a patient who developed features of obsessive-compulsive disorder (OCD) and anorexia nervosa (AN) as the initial presentation of Creutzfeldt-Jakob disease. He had mild Parkinsonism and showed deficits in visual scanning, set shifting, graphomotor speed, sequencing, and verbal and nonverbal memory. Neuropathological study showed spongiosis and neuronal loss in cortical (e.g., frontal, temporal, parietal), and especially in subcortical structures (e.g., basal ganglia, thalamus). This study supports the hypothesis of abnormal frontal-striatal functioning in the cause of OCD, even in demented subjects. In addition, the authors discuss the role of frontal-temporal-subcortical dysfunction in the cause of acquired AN.
Lopez
O L
OL
Department of Neurology, Alzheimer's Disease Research Center University of Pittsburgh, School of Medicine, Pennsylvania, USA.
Berthier
M L
ML
Backer
J T
JT
Boller
F
F
D000368:Aged; D000856:Anorexia Nervosa / Q000175:diagnosis / Q000503:physiopathology* / Q000523:psychology; D001921:Brain / Q000473:pathology / Q000503:physiopathology*; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000473:pathology / Q000503:physiopathology*; D007562:Creutzfeldt-Jakob Syndrome / Q000175:diagnosis / Q000503:physiopathology* / Q000523:psychology; D003937:Diagnosis, Differential; D006801:Humans; D008297:Male; D019965:Neurocognitive Disorders / Q000175:diagnosis / Q000503:physiopathology* / Q000523:psychology; D009460:Neurologic Examination; D009483:Neuropsychological Tests; D009771:Obsessive-Compulsive Disorder / Q000175:diagnosis / Q000503:physiopathology* / Q000523:psychology; D010302:Parkinson Disease, Secondary / Q000175:diagnosis / Q000503:physiopathology / Q000523:psychology