title: Reverse middle-ear transfer function in the guinea pig measured with cubic difference tones.
abstract: Otoacoustic emissions are increasingly useful for determining cochlear function noninvasively. It is widely agreed that these acoustic signals reflect micromechanical processes in the cochlea. However, their quantitative interpretation requires knowledge of the ways in which vibrations travelling back to the ear canal from the cochlea are shaped by the middle ear. An intracochlear source is needed to derive the reverse middle-ear transfer function (rMETF) by comparing pressure in the external ear canal to the corresponding pressure in scala vestibuli. In the present study, the rMETF was obtained in vivo in the guinea pig using as intracochlear sound source the cubic difference tones (CDTs) generated by a pair of external pure tones. With a closed ear canal and open bulla, the rMETF was found to be flat (-35 dB) over a broad frequency range (1.5-8 kHz). The differences between forward and reverse METF could be explained by different loads acting on the middle ear network, which depends on the direction of signal transmission. With knowledge of the rMETF, it becomes possible to quantify CDTs within the cochlea by measuring them noninvasively in the ear canal.
authors.affiliation: Institut Franco-Allemand de Recherches, Saint-Louis, France. dancer@nucleus.fr
authors.forename: P
authors.initials: P
authors.lastname: Magnan
authors.forename: P
authors.initials: P
authors.lastname: Avan
authors.forename: A
authors.initials: A
authors.lastname: Dancer
authors.forename: J
authors.initials: J
authors.lastname: Smurzynski
authors.forename: R
authors.initials: R
authors.lastname: Probst
mesh_terms: D000161:Acoustic Stimulation; D000818:Animals; D003051:Cochlea / Q000502:physiology; D004432:Ear, Middle / Q000502:physiology*; D005260:Female; D006168:Guinea Pigs; D017084:Otoacoustic Emissions, Spontaneous / Q000502:physiology*; D011312:Pressure