Mechanisms underlying neuronal migration disorders and epilepsy.
Neuronal migration disorders are often associated with intractable epilepsy. These cortical malformations are quite heterogeneous, suggesting that they may result from interference with a diverse set of processes during corticogenesis. Progress toward understanding the pathophysiologic basis of these disorders is coming from research into the basic mechanisms of corticogenesis, animal models of cortical malformations, and molecular genetic approaches to migration disorders.
Flint
A C
AC
Center for Neurobiology and Behavior, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA.
Kriegstein
A R
AR
D000818:Animals; D002465:Cell Movement / Q000235:genetics / Q000502:physiology*; D002540:Cerebral Cortex / Q000002:abnormalities* / Q000503:physiopathology; D004195:Disease Models, Animal; D004827:Epilepsy / Q000235:genetics / Q000503:physiopathology*; D006801:Humans; D008957:Models, Genetic; D008967:Molecular Biology; D009457:Neuroglia / Q000502:physiology; D009474:Neurons / Q000502:physiology