title: Sleep-related hypoxaemia in chronic obstructive pulmonary disease: causes, consequences and treatment.
abstract: Worsening of hypoxaemia during sleep in patients with chronic obstructive pulmonary disease has been extensively investigated in the past 20 years owing to the development of polysomnography and to the advent of reliable transcutaneous oximeters. Sleep-related hypoxaemia is characteristic of rapid-eye-movement (REM) sleep but may be present during other sleep stages. There is a strong relationship between nocturnal O2 saturation and the level of daytime PaO2: the more pronounced daytime hypoxaemia, the more severe nocturnal hypoxaemia. Sleep-related hypoxaemia is due to a variable combination of alveolar hypoventilation and ventilation-perfusion mismatching, alveolar hypoventilation being the preponderant mechanism during REM sleep. The deleterious effects of sleep-related hypoxaemia include cardiac arrhythmias, 'hypoxaemic stress' on the coronary circulation and especially, peaks of pulmonary hypertension. The treatment of nocturnal hypoxaemia is conventional O2 therapy (both nighttime and daytime) in patients who exhibit marked daytime hypoxaemia (PaO2 < 55-60 mm Hg). At present data are not sufficient for justifying the use of isolated nocturnal O2 therapy in patients with nocturnal desaturation who do not qualify for conventional O2 therapy.
authors.affiliation: Department of Pulmonology and Sleep Laboratory, University Hospital, Strasbourg, France.
authors.forename: E
authors.initials: E
authors.lastname: Weitzenblum
authors.forename: A
authors.initials: A
authors.lastname: Chaouat
authors.forename: C
authors.initials: C
authors.lastname: Charpentier
authors.forename: M
authors.initials: M
authors.lastname: Ehrhart
authors.forename: R
authors.initials: R
authors.lastname: Kessler
authors.forename: P
authors.initials: P
authors.lastname: Schinkewitch
authors.forename: J
authors.initials: J
authors.lastname: Krieger
mesh_terms: D002986:Clinical Trials as Topic; D006801:Humans; D000860:Hypoxia / Q000150:complications* / Q000453:epidemiology / Q000503:physiopathology / Q000628:therapy; D008173:Lung Diseases, Obstructive / Q000150:complications* / Q000503:physiopathology / Q000628:therapy; D010100:Oxygen / Q000627:therapeutic use*; D010101:Oxygen Consumption; D011379:Prognosis; D011652:Pulmonary Circulation; D012307:Risk Factors; D012891:Sleep Apnea Syndromes / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy*; D012895:Sleep, REM; D013610:Tachycardia
chemical_list: D010100:Oxygen