Suppression or overexpression of genes encoding myeloid growth factors or their receptors.
Gene inactivation data have documented that erythropoietin, G-CSF, M-CSF and thrombopoietin are major regulators in vivo respectively of red cell, neutrophil, macrophage and platelet production. Transgenic mice can provide valuable models for observing the consequences of excessive stimulation by a particular growth factor but are subject to variation based on the use of differing promoters for the inserted gene.
Metcalf
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Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia.
D000818:Animals; D003115:Colony-Stimulating Factors / Q000037:antagonists & inhibitors* / Q000096:biosynthesis / Q000235:genetics*; D005786:Gene Expression Regulation; D051379:Mice; D016184:Receptors, Colony-Stimulating Factor / Q000037:antagonists & inhibitors* / Q000096:biosynthesis / Q000235:genetics*
D003115:Colony-Stimulating Factors; D016184:Receptors, Colony-Stimulating Factor