Immunohistochemistry of vascular changes in leuprolide acetate-treated leiomyomas.
We report two cases of leuprolide acetate-treated leiomyomas with striking vascular changes and histologic features of vasculitis and atherosclerosis. These changes may cause ischemic damage if they occur in other organs. We describe the histologic findings and discuss their clinical implications.
Mesia
A F
AF
Department of Obstetric-Gynecologic Pathology, New York University Medical Center, NY 10016, USA.
Gahr
D
D
Wild
M
M
Mittal
K
K
Demopoulos
R I
RI
D000328:Adult; D001161:Arteriosclerosis; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007889:Leiomyoma / Q000098:blood supply* / Q000188:drug therapy* / Q000473:pathology; D016729:Leuprolide / Q000009:adverse effects / Q000627:therapeutic use*; D014594:Uterine Neoplasms / Q000098:blood supply* / Q000188:drug therapy* / Q000473:pathology; D014657:Vasculitis
D016729:Leuprolide