Lack of inhibitory effect of cimetidine on caffeine metabolism in children using the caffeine breath test.
OBJECTIVE
To study the potential drug interaction between cimetidine and caffeine in a group of children who received cimetidine for gastritis.


METHODS
The caffeine breath test was carried out prior to the administration of cimetidine and after 2-3 weeks therapy. The children (n = 1) received 300-800 mg cimetidine daily (11-36 mg kg(-1) day(-1)).


RESULTS
There was no significant change in the 2 h cumulative labelled CO2 following the administration of cimetidine (mean values 5.61% before and 4.87% during cimetidine; Student's t-test P > 0.2).


CONCLUSIONS
Cimetidine did not have an inhibitory effect on the metabolism of caffeine in this group of children studied.
Parker
A C
AC
Institute of Child Health, Alder Hey Children's Hospital, Liverpool, UK.
Pritchard
P
P
Preston
T
T
Dalzell
A M
AM
Choonara
I
I
D000293:Adolescent; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D001711:Biotransformation; D001944:Breath Tests; D002110:Caffeine / Q000493:pharmacokinetics*; D002247:Carbon Isotopes; D002648:Child; D002675:Child, Preschool; D002927:Cimetidine / Q000494:pharmacology*; D004347:Drug Interactions; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D010726:Phosphodiesterase Inhibitors / Q000493:pharmacokinetics*
D000897:Anti-Ulcer Agents; D002247:Carbon Isotopes; D010726:Phosphodiesterase Inhibitors; D002110:Caffeine; D002927:Cimetidine