Eicosanoids and the esophagus.
Eicosanoids are metabolites of arachidonic acid and include, among other compounds, the prostaglandins and leukotrienes. These metabolites are known to play important roles in the health and disease of many gastrointestinal tissues. Less attention, however, has been given to their functions in the esophagus. The present study, therefore, aims both to review the current knowledge about eicosanoids in healthy and diseased esophagi, and to critically assess the data pertaining to their role in the pathophysiology of gastroesophageal reflux disease.
Long
J D
JD
Department of Medicine, Tulane University Medical Center, New Orleans, La 70112-2699, USA.
Orlando
R C
RC
D019377:12-Hydroxy-5,8,10,14-eicosatetraenoic Acid / Q000096:biosynthesis; D000818:Animals; D015232:Dinoprostone / Q000032:analysis; D015777:Eicosanoids / Q000032:analysis / Q000096:biosynthesis / Q000502:physiology*; D004935:Esophageal Diseases / Q000503:physiopathology*; D004941:Esophagitis / Q000503:physiopathology; D004947:Esophagus / Q000737:chemistry; D005764:Gastroesophageal Reflux / Q000503:physiopathology*; D006801:Humans
D015777:Eicosanoids; D019377:12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; D015232:Dinoprostone