title: [Biochemical study of testicular biopsy in infertility].
abstract: Basic semen tests nowadays contain no variables that may allow to certify that a man is fertile. Starting from this premise it could be clinically very useful, for the diagnosis of male infertility, to evaluate a parameter that may be related to sexual maturity and be specific of the germinal tissue, such as the C4-lactate dehydrogenase isoenzyme (C4-LDH), which could indicate the activity of the germinal epithelium and the quality of the spermatozoa. In our experience, C4-LDH activity in seminal plasma discriminates between fertile and non-fertile males; also, their testicular study has a good correlation both with histologically diagnosed disease and the seminal plasma levels. All of which suggest the diagnostic validity of plasma C4-LDH in male infertility, as a routine test which thus precludes the use of invasive techniques in the patient.
authors.affiliation: Servicio de Análisis Clínicos, Hospital Universitario Virgen de la Arrixaca, Murcia.
authors.forename: M L
authors.initials: ML
authors.lastname: Gil
authors.forename: J M
authors.initials: JM
authors.lastname: Pérez-Jaranay
authors.forename: M
authors.initials: M
authors.lastname: Pérez-Albacete
authors.forename: J A
authors.initials: JA
authors.lastname: Noguera
authors.forename: I
authors.initials: I
authors.lastname: Tovar
authors.forename: P
authors.initials: P
authors.lastname: Martínez
mesh_terms: D000328:Adult; D001706:Biopsy; D006801:Humans; D007248:Infertility, Male / Q000175:diagnosis* / Q000201:enzymology*; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000378:metabolism*; D008297:Male; D013737:Testis / Q000201:enzymology* / Q000473:pathology
chemical_list: D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase
vernacular_title: Estudio bioquímico de biopsia testicular en infertilidad.