title: Influence of data processing on cyclic variation of integrated backscatter and wall thickness in stunned porcine myocardium.
abstract: This study was performed to investigate the relationship between the cyclic variation of integrated backscatter and myocardial wall thickening in stunned myocardium. Different definitions of cyclic variation were evaluated to be able to compare with other studies. Ultrasound data were acquired from 10 open-chested Yorkshire pigs (25-33 kg) at baseline, during regional ischemia and during 30 min of stunning, using a broadband ultrasound transducer (3-7 MHz) sutured directly upon the left ventricular myocardial wall. Cyclic variation of integrated backscatter and myocardial wall thickening were calculated using three definitions obtained from the literature. Independent of the definition, cyclic variation of wall thickness and integrated backscatter were blunted during acute ischemia and returned transiently to or above baseline during the first minute of reperfusion, followed by a gradual decrease to a level under baseline during stunning. An early return of the cyclic variation of the integrated backscatter was not observed in pigs, independent of the data processing used. The relationship between integrated backscatter and wall thickness was maintained.
authors.affiliation: Department of Cardiology, Thoraxcenter, Erasmus University Rotterdam, The Netherlands.
authors.forename: A F
authors.initials: AF
authors.lastname: van der Steen
authors.forename: H
authors.initials: H
authors.lastname: Rijsterborgh
authors.forename: C T
authors.initials: CT
authors.lastname: Lancee
authors.forename: F
authors.initials: F
authors.lastname: Mastik
authors.forename: R
authors.initials: R
authors.lastname: Krams
authors.forename: P D
authors.initials: PD
authors.lastname: Verdouw
authors.forename: J R
authors.initials: JR
authors.lastname: Roelandt
authors.forename: N
authors.initials: N
authors.lastname: Bom
mesh_terms: D000818:Animals; D004452:Echocardiography / Q000379:methods*; D001330:Electronic Data Processing; D005260:Female; D005583:Fourier Analysis; D008297:Male; D017682:Myocardial Stunning / Q000000981:diagnostic imaging*; D010507:Periodicity; D012542:Scattering, Radiation; D013552:Swine; D014159:Transducers