Histamine-release effectors from Angelica dahurica var. dahurica root.
Six compounds isolated from the EtOAc fraction of the dried roots of Angelica dahurica var. dahurica inhibited compound 48/80-induced histamine levels in mouse peritoneal cavity (in vivo). Bergapten, oxypeucedanin hydrate, and byakangelicin inhibited compound 48/80-induced histamine elevation at a dose of 25 mg/kg. Conversely, sec-O-acetylbyakangelicin [8-(2-acetoxy-3-hydroxy-3-methylbutoxy)-5-methoxypsoralenI enhanced compound 48/80-induced histamine elevation at a dose of 25 mg/kg, while phellopterin and oxypeucedanin had no effect.
Kimura
Y
Y
2nd Department of Medicinal Biochemistry, School of Medicine, Ehime University, Japan.
Okuda
H
H
D000818:Animals; D017442:Histamine Agonists / Q000302:isolation & purification / Q000494:pharmacology*; D006633:Histamine Antagonists / Q000302:isolation & purification / Q000494:pharmacology*; D006636:Histamine Release / Q000187:drug effects*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D010529:Peritoneal Cavity / Q000166:cytology; D010936:Plant Extracts / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry*; D003189:p-Methoxy-N-methylphenethylamine / Q000494:pharmacology
D017442:Histamine Agonists; D006633:Histamine Antagonists; D010936:Plant Extracts; D003189:p-Methoxy-N-methylphenethylamine