Recurrent Clostridium difficile diarrhea associated with mitoxantrone and etoposide: a case report and review.
Clostridium difficile colitis most commonly occurs in association with antibiotic administration and infrequently with antineoplastic agents. Our patient experienced recurrent C. difficile diarrhea associated with mitoxantrone and etoposide. He received antibiotics during the 6 months, but each episode of diarrhea was preceded by at least a 6-week antibiotic-free period. In addition, antineoplastic therapy preceded each episode by 8 or 9 days. Clinicians should be aware that antineoplastic drugs may precipitate overgrowth of C. difficile in the bowel.
Jarvis
B
B
Department of Pharmaceutical Services, Saskatoon District Health Board, University of Saskatchewan, Canada.
Shevchuk
Y M
YM
D000208:Acute Disease; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use; D003967:Diarrhea / Q000139:chemically induced* / Q000188:drug therapy; D004761:Enterocolitis, Pseudomembranous / Q000139:chemically induced* / Q000188:drug therapy; D005047:Etoposide / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D007951:Leukemia, Myeloid / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D008942:Mitoxantrone / Q000008:administration & dosage / Q000009:adverse effects; D012008:Recurrence
D000900:Anti-Bacterial Agents; D005047:Etoposide; D008942:Mitoxantrone