title: Particulate matter determination in LVPs produced in Dutch hospital pharmacies, Part 1: Particle-counting accuracy.
abstract: Reproducible particle counting using the light-obscuration technique is often troublesome because no absolute standard is available. Therefore, at the Laboratory of Dutch Pharmacists the "calibration-in-time" method was developed. This method enables checking of the amount of particles counted from a diluted latex suspension as a function of time. A particularity of the method is the one-step dilution procedure. The calibration-in-time method is compared with the particle-counting accuracy test according to the USP < 788 >. Advantages and disadvantages of both methods are discussed.
authors.affiliation: Laboratory of Dutch Pharmacists (LNA), Den Haag, The Netherlands.
authors.forename: J
authors.initials: J
authors.lastname: Van der Veen
authors.forename: P
authors.initials: P
authors.lastname: Verbrugge
authors.forename: F J
authors.initials: FJ
authors.lastname: Van de Vaart
authors.forename: F A
authors.initials: FA
authors.lastname: Boom
mesh_terms: D002138:Calibration; D004340:Drug Contamination / Q000517:prevention & control; D007263:Infusions, Parenteral / Q000592:standards*; D007840:Latex / Q000737:chemistry; D009426:Netherlands; D010316:Particle Size; D010607:Pharmacy Service, Hospital / Q000592:standards*; D011786:Quality Control; D015203:Reproducibility of Results; D012996:Solutions / Q000032:analysis / Q000592:standards; D013242:Sterilization / Q000592:standards; D013535:Suspensions / Q000032:analysis / Q000592:standards*; D007507:Therapeutic Irrigation / Q000592:standards
chemical_list: D007840:Latex; D012996:Solutions; D013535:Suspensions