title: Aggressive gastric peripheral T-cell lymphoma of CD8+ type associated with lymphomatous meningitis.
abstract: Most gastric lymphomas are of B-cell origin, and many are either low-grade or high-grade B-cell lymphomas of mucosa-associated lymphoid tissue type. Gastric T-cell lymphomas are very rare, usually of CD4+ type, and few have had genotypic studies. We report the case of a gastric peripheral T-cell lymphoma of CD8+ type. Genotypic studies demonstrated partial deletion with rearrangement of the T-cell receptor beta-chain gene. Lymphomatous meningitis developed, and the patient died after only 2 months despite chemotherapy. The case is compared with the other gastric T-cell lymphomas that have been reported.
authors.affiliation: Department of Pathology, University of Pittsburgh Medical Center, Pennsylvania 15213-2582, USA.
authors.forename: V A
authors.initials: VA
authors.lastname: Holst
authors.forename: J
authors.initials: J
authors.lastname: Locker
authors.forename: J A
authors.initials: JA
authors.lastname: Gleason
authors.forename: S H
authors.initials: SH
authors.lastname: Swerdlow
mesh_terms: D000368:Aged; D018951:Antigens, CD20 / Q000032:analysis; D015415:Biomarkers / Q000032:analysis; D001706:Biopsy; D017252:CD3 Complex / Q000032:analysis; D016827:CD8 Antigens / Q000032:analysis*; D016543:Central Nervous System Neoplasms / Q000556:secondary; D017809:Fatal Outcome; D005434:Flow Cytometry; D006801:Humans; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D016411:Lymphoma, T-Cell, Peripheral / Q000737:chemistry / Q000473:pathology*; D008297:Male; D008581:Meningitis / Q000473:pathology; D013274:Stomach Neoplasms / Q000473:pathology*
chemical_list: D018951:Antigens, CD20; D015415:Biomarkers; D017252:CD3 Complex; D016827:CD8 Antigens