Low-density lipoprotein adsorption for arteriosclerotic patients.
A wide variety of treatments is now available for arteriosclerosis obliterans (ASO) patients, not very successful in some cases. Low-density lipoprotein (LDL) apheresis using an extracorporeal adsorption column containing dextran sulfate cellulose beads was applied to control lipid levels intensively in ASO patients with accompanying drug-resistant hyperlipidemia. A series of the apheresis procedures had a remarkable impact on clinical symptoms and physiological findings with improvement in intermittent claudication observed in more than 80% of the patients. Improvements in plethysmogram and thermogram readings suggested an increased circulation in lower extremities in more than 80% of patients. In addition, the treatment improved blood rheology, as evidenced by a reduction in blood viscosity. In a follow-up study made by sending a questionnaire to previously treated patients it was revealed that improvements in clinical symptoms were well maintained even after cessation of the treatment. In conclusion, LDL apheresis proved to be a useful therapeutic tool in ASO patients having elevated lipid levels.
Sato
Y
Y
Kidney Center, Tokyo Women's Medical College, Japan.
Agishi
T
T
D000327:Adsorption; D000368:Aged; D001162:Arteriosclerosis Obliterans / Q000628:therapy*; D002482:Cellulose / Q000737:chemistry / Q000378:metabolism; D002784:Cholesterol / Q000097:blood / Q000302:isolation & purification; D008078:Cholesterol, LDL / Q000097:blood / Q000302:isolation & purification*; D016264:Dextran Sulfate / Q000737:chemistry / Q000378:metabolism; D005260:Female; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000628:therapy; D008297:Male; D010956:Plasmapheresis / Q000009:adverse effects / Q000592:standards; D010991:Plethysmography; D011795:Surveys and Questionnaires
D008078:Cholesterol, LDL; D002482:Cellulose; D016264:Dextran Sulfate; D002784:Cholesterol