title: Multicomponent spectroscopic investigations of salivary antioxidant consumption by an oral rinse preparation containing the stable free radical species chlorine dioxide (ClO2.).
abstract: A multicomponent evaluation of the oxidative consumption of salivary biomolecules by a commercially-available oral rinse preparation containing an admixture of the stable free radical species chlorine dioxide (ClO2.) with chlorite anion (ClO2-) has been investigated using high resolution 1H NMR spectroscopy. The results obtained demonstrated that ClO2. and/or ClO2- present in this preparation effected the oxidative decarboxylation of salivary pyruvate (to acetate and CO2). Experiments conducted on chemical model systems confirmed the oxidative decarboxylation of pyruvate by this oral rinse, and also demonstrated that urate, thiocyanate anion, and the amino acids cysteine and methionine (precursors to volatile sulphur compounds responsible for oral malodour), were oxidatively consumed. The biochemical, periodontal and therapeutic significance of the results are discussed.
authors.affiliation: Department of Conservative Dentistry, St. Bartholomews Hospital School of Medicine and Dentistry, London, U.K.
authors.forename: E
authors.initials: E
authors.lastname: Lynch
authors.forename: A
authors.initials: A
authors.lastname: Sheerin
authors.forename: A W
authors.initials: AW
authors.lastname: Claxson
authors.forename: M D
authors.initials: MD
authors.lastname: Atherton
authors.forename: C J
authors.initials: CJ
authors.lastname: Rhodes
authors.forename: C J
authors.initials: CJ
authors.lastname: Silwood
authors.forename: D P
authors.initials: DP
authors.lastname: Naughton
authors.forename: M
authors.initials: M
authors.lastname: Grootveld
mesh_terms: D000042:Absorption; D002713:Chlorine / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use; D017606:Chlorine Compounds; D004578:Electron Spin Resonance Spectroscopy; D005260:Female; D005609:Free Radicals / Q000494:pharmacology*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008956:Models, Chemical; D009067:Mouthwashes / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D010084:Oxidation-Reduction; D010087:Oxides / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use; D010101:Oxygen Consumption / Q000187:drug effects; D012463:Saliva / Q000737:chemistry* / Q000187:drug effects / Q000378:metabolism; D013057:Spectrum Analysis / Q000379:methods*
chemical_list: D017606:Chlorine Compounds; D005609:Free Radicals; D009067:Mouthwashes; D010087:Oxides; C091018:RetarDEX oral rinse; D002713:Chlorine; C025109:chlorine dioxide