title: Increased DNA fragmentation in isolated rat islets following 24 hour co-culture with cytokine transgene-bearing adenovirus is dose dependent, but does not reduce glucose-stimulated insulin secretion.
authors.affiliation: Department of Surgery, Harrison Department of Surgical Research, University of Pennsylvania Medical Center, PA, USA.
authors.forename: M
authors.initials: M
authors.lastname: Weber
authors.forename: S
authors.initials: S
authors.lastname: Deng
authors.forename: T
authors.initials: T
authors.lastname: Kucher
authors.forename: A
authors.initials: A
authors.lastname: Shaked
authors.forename: R J
authors.initials: RJ
authors.lastname: Ketchum
authors.forename: K L
authors.initials: KL
authors.lastname: Brayman
mesh_terms: D000256:Adenoviridae; D000818:Animals; D002478:Cells, Cultured; D018920:Coculture Techniques; D053938:DNA Fragmentation; D015316:Genetic Therapy / Q000379:methods; D005947:Glucose / Q000494:pharmacology*; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000166:cytology* / Q000187:drug effects / Q000502:physiology*; D007763:Lac Operon; D051381:Rats; D011917:Rats, Inbred Lew; D011994:Recombinant Proteins / Q000096:biosynthesis / Q000378:metabolism; D014162:Transfection; D016212:Transforming Growth Factor beta / Q000096:biosynthesis* / Q000378:metabolism; D001616:beta-Galactosidase / Q000096:biosynthesis
chemical_list: D007328:Insulin; D011994:Recombinant Proteins; D016212:Transforming Growth Factor beta; D001616:beta-Galactosidase; D005947:Glucose