Inhibition of Fe(2+)-induced lipid peroxidation in egg yolk lipoproteins by metallothionein.
Rat hepatic apometallothionein and to a lesser extent Zn-metallothionein inhibit Fe(2+)-dependent lipid peroxidation (LPO) in suspensions of egg yolk lipoproteins. ZnCl2 or its combination with cysteine at corresponding concentrations activate LPO.
Koterov
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Russian State Research Center, Institute of Biophysics, Moscow, Russia. ibkoguc@alara:msk.su
D000818:Animals; D001059:Apoproteins / Q000494:pharmacology; D004530:Egg Yolk; D066298:In Vitro Techniques; D007501:Iron / Q000378:metabolism / Q000494:pharmacology*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008074:Lipoproteins / Q000737:chemistry / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008668:Metallothionein / Q000494:pharmacology*; D051381:Rats
D001059:Apoproteins; D008074:Lipoproteins; C021267:zinc thionein; D008668:Metallothionein; D007501:Iron