[Changes in the blood circulation in the middle cerebral and common carotid arteries of rats under the influence of flunarizine].
Experiments conducted on Wistar rats under general anesthesia using the Doppler ultrasonic method showed that flunarizine caused a slowly developing (for 20 min), moderate (25%), and prolonged (90 min) increase of the blood flow in the middle cerebral artery. In the common carotid artery the drug induced two-phase changes in blood circulation. The initial increase in the blood flow was replaced by its reduction below the basic level.
Semkina
G A
GA
Matsievskiĭ
D D
DD
Mirzoian
R S
RS
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D017536:Carotid Artery, Common / Q000187:drug effects* / Q000502:physiology; D002536:Cerebral Arteries / Q000187:drug effects* / Q000502:physiology; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D005444:Flunarizine / Q000494:pharmacology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors; D014665:Vasodilator Agents / Q000494:pharmacology*
D002121:Calcium Channel Blockers; D014665:Vasodilator Agents; D005444:Flunarizine
Izmeneniia krovoobrashcheniia v sredneĭ mozgovoĭ i obshcheĭ sonnoĭ arteriiakh krys pod vliianiem flunarizina.