Spasmolytic activity of aurapten analogs.
Seven coumaric compounds analogous to aurapten were synthesized. Their spasmolytic activity against Ba2+, acetylcholine and histamine was evaluated to investigate their structure-activity relationship. The results of the bioassay demonstrated the important roles of the cis type of double bond at C-2' and the epoxide between c-6' and 7'.
Yamada
Y
Y
Department of Food Science and nutrition, Faculty of Human Life and Science, Doshisha Women's College, Kyoto, Japan.
Okamoto
M
M
Kikuzaki
H
H
Nakatani
N
N
D000109:Acetylcholine / Q000037:antagonists & inhibitors; D001464:Barium / Q000037:antagonists & inhibitors; D003374:Coumarins / Q000737:chemistry / Q000494:pharmacology*; D006633:Histamine Antagonists / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D010276:Parasympatholytics / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D003374:Coumarins; D006633:Histamine Antagonists; D010276:Parasympatholytics; D001464:Barium; C105832:aurapten; D000109:Acetylcholine