Induction of nitric oxide synthase by chlorinated pesticides (p,p'-DDT, chlordane, endosulfan) in rat liver.
The aim of this study is to investigate the effect of certain polychlorinated pesticides on the induction of rat liver Ca(2+)-independent nitric oxide synthase (NOS) and compare it with the effect of bacterial lipopolysaccharide. Our results show that endosulfan and p, p'-DDT treatment significantly increases the NOS activity while no significant induction by any route of administration was observed in the case of chlordane. Our results show therefore that a wide variety of chlorinated pesticides, which are considered as hepatic tumor promotors, can stimulate the expression of NO synthase in vivo.
Dhouib
M
M
Laboratory for General Toxicology and Environment, Faculty of Pharmacy, Louis Pasteur University, Strasbourg, France.
Lugnier
A
A
D000818:Animals; D008099:Liver / Q000201:enzymology*; D019001:Nitric Oxide Synthase / Q000096:biosynthesis*; D051381:Rats; D017208:Rats, Wistar; D014158:Transcription, Genetic
D019001:Nitric Oxide Synthase