Allele frequency of ADH2 and ALDH2 among Brazilians of different ethnic groups.
We determined the genotypes of the alcohol dehydrogenase (ALDH) and aldehyde dehydrogenase (ALDH2) loci of different ethnic groups living in Brazil, using saliva DNA amplified by PCR and allele-specific oligonucleotides. Self-reports of flushing reaction after drinking were also studied. The allelic frequencies of ADH2 and ALDH2 were found to be lower than those reported other authors, which might be a result of the admixture origin of the Brazilian population. Variability in facial flushing reaction suggests that other factors play a role in the expression of alcohol-induced flushing.
Santos
B R
BR
Department of Pharmacology, Universidade Federal de Uberlandia, Minas Gerais, Brazil.
Monteiro
M G
MG
Thomasson
H R
HR
D000426:Alcohol Dehydrogenase / Q000235:genetics*; D000444:Aldehyde Dehydrogenase / Q000235:genetics*; D000483:Alleles; D001938:Brazil / Q000208:ethnology; D005260:Female; D006801:Humans; D008297:Male
D000426:Alcohol Dehydrogenase; D000444:Aldehyde Dehydrogenase