title: [Acute cytolytic hepatitis caused by coumarin. 2 cases].
abstract: Coumarin is a drug which is extensively used to treat lymphedema. We report two cases of acute hepatitis probably due to coumarin. Two women, 40 year and 45 year-old, were treated with 90 mg/d of coumarin for 5 months. Clinical features included jaundice, pruritus, and diarrhea. A marked increase in serum aminotransferases was observed (ALT: 30 and 100 times the upper limit of normal, respectively). Coumarin withdrawal was rapidly followed by a favorable outcome in both cases. Rechallenge in one case induced a relapse of symptoms and liver test abnormalities. Coumarin can induce acute cytolytic hepatitis.
authors.affiliation: Service d'Hépatologie et de Soins Intensifs Digestifs, CHRU Jean Minjoz, Besançon.
authors.forename: S
authors.initials: S
authors.lastname: Koch
authors.forename: I
authors.initials: I
authors.lastname: Beurton
authors.forename: S
authors.initials: S
authors.lastname: Bresson-Hadni
authors.forename: B
authors.initials: B
authors.lastname: Monnot
authors.forename: S
authors.initials: S
authors.lastname: Hrusovsky
authors.forename: M C
authors.initials: MC
authors.lastname: Becker
authors.forename: C
authors.initials: C
authors.lastname: Vanlemmens
authors.forename: J P
authors.initials: JP
authors.lastname: Carbillet
authors.forename: J P
authors.initials: JP
authors.lastname: Miguet
mesh_terms: D000208:Acute Disease; D000328:Adult; D000925:Anticoagulants / Q000009:adverse effects / Q000627:therapeutic use*; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D003374:Coumarins / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008875:Middle Aged; D014689:Venous Insufficiency / Q000188:drug therapy
chemical_list: D000925:Anticoagulants; D003374:Coumarins; C030123:coumarin
vernacular_title: Hépatite aiguë cytolytique à la coumarine. Deux cas.