A region of interstitial 17q25 allelic loss in ovarian tumors coincides with a defined region of loss in breast tumors.
Chromosomal regions of allelic imbalance in tumors are predicted to define the general location of tumor suppressor genes. We previously localized a putative breast tumor suppressor gene to a 3 cM region on 17q25 by deletion mapping of microsatellite markers in breast tumors. To determine if the same 17q25 region of loss is important in the genesis of other tumor types, 32 ovarian tumors and 24 prostate tumors, as well as 33 additional breast tumors, were analysed with 17q25 polymorphic microsatellite markers. While no significant loss was observed in prostate tumors, greater than half of ovarian tumors exhibited loss coincident with the candidate region previously defined in breast tumors. These results suggest that one or more novel tumor suppressor genes exist on 17q25 within a concordant region of interstitial loss defined in both breast and ovarian neoplasms.
Kalikin
L M
LM
Department of Internal Medicine, The University of Michigan Medical School, Ann Arbor 48109-0638, USA.
Frank
T S
TS
Svoboda-Newman
S M
SM
Wetzel
J C
JC
Cooney
K A
KA
Petty
E M
EM
D001943:Breast Neoplasms / Q000235:genetics*; D002874:Chromosome Mapping; D002886:Chromosomes, Human, Pair 17; D005260:Female; D017353:Gene Deletion; D005819:Genetic Markers; D006801:Humans; D008297:Male; D018895:Microsatellite Repeats; D010051:Ovarian Neoplasms / Q000235:genetics*; D011110:Polymorphism, Genetic; D011471:Prostatic Neoplasms / Q000235:genetics
D005819:Genetic Markers