Regulation of the RAG-1 promoter by the NF-Y transcription factor.
We have cloned the RAG-1 promoter region and have determined that almost all detectable promoter activity resides within a 208-bp fragment. Sequence analysis of this promoter region has identified potential recognition motifs for a number of lymphocyte-restricted and ubiquitous transcription factors. Subsequent assays have revealed that the NF-Y transcription factor interacts with a CCAAT site within the RAG-1 promoter and appears to play an important role in the positive transcriptional regulation of this gene.
Brown
S T
ST
Department of Molecular, Cell, and Developmental Biology, Molecular Biology Institute, University of California at Los Angeles, 90095, USA.
Miranda
G A
GA
Galic
Z
Z
Hartman
I Z
IZ
Lyon
C J
CJ
Aguilera
R J
RJ
D016475:3T3 Cells; D000818:Animals; D001483:Base Sequence; D022762:CCAAT-Enhancer-Binding Proteins; D004268:DNA-Binding Proteins / Q000235:genetics*; D005786:Gene Expression Regulation; D018398:Homeodomain Proteins; D051379:Mice; D008969:Molecular Sequence Data; D011401:Promoter Regions, Genetic / Q000235:genetics*; D011506:Proteins / Q000235:genetics* / Q000276:immunology; D014157:Transcription Factors / Q000235:genetics / Q000276:immunology; D014158:Transcription, Genetic
D022762:CCAAT-Enhancer-Binding Proteins; D004268:DNA-Binding Proteins; D018398:Homeodomain Proteins; D011506:Proteins; D014157:Transcription Factors; C064658:RAG-1 protein