title: Atypical strains of Candida albicans recovered from AIDS patients.
abstract: By using multilocus enzyme electrophoresis (MLEE) we have analyzed the genetic diversity encountered among chlamydospore-positive Candida albicans strains. While the type II strains of the former C. stellatoidea were genetically indistinguishable from those of C. albicans, type I strains constituted a distinct subgroup compared with C. albicans strains. Nevertheless, all these strains remained genetically very closely related compared with other species of Candida (e.g. C. tropicalis, C. krusei and C. glabrata). These results corroborate the synonymy between C. stellatoidea and C. albicans. Chlamydospore-positive C. albicans strains with atypical sugar assimilation patterns displayed a great genetic divergence from the cluster constituted by C. albicans and the strains of the former C. stellatoidea. However, these atypical strains were more closely related to C. albicans than they were to C. tropicalis, C. krusei or C. glabrata. These strains represent a genetically entity distinct from the typical C. albicans strains used in this study. The data also support the view that the atypical strains described here belong to the same genetic group as atypical C. albicans strains previously described by others.
authors.affiliation: Laboratoire d'Immunologie-Parasitologie, Faculté de Pharmacie, Montpellier, France.
authors.forename: C
authors.initials: C
authors.lastname: Pujol
authors.forename: F
authors.initials: F
authors.lastname: Renaud
authors.forename: M
authors.initials: M
authors.lastname: Mallié
authors.forename: T
authors.initials: T
authors.lastname: de Meeûs
authors.forename: J M
authors.initials: JM
authors.lastname: Bastide
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000382:microbiology*; D000483:Alleles; D002175:Candida / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification; D002176:Candida albicans / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification; D002177:Candidiasis / Q000209:etiology / Q000382:microbiology*; D004798:Enzymes / Q000235:genetics; D005787:Gene Frequency; D014644:Genetic Variation; D006801:Humans; D010802:Phylogeny
chemical_list: D004798:Enzymes