title: Protective effects of dietary lactulose and calcium phosphate against Salmonella infection.
abstract: Protection against intestinal infections by lactulose fermentation might be enhanced by calcium phosphate, due to the increased buffering capacity and/or inhibition of the cytotoxicity of luminal contents.
  
  
  
  SPF rats were fed a low-calcium control diet, a low-calcium/lactulose diet or a high-calcium/lactulose diet and orally infected with Salmonella enteritidis. Faeces and urine were sampled for microbiological and chemical analyses.
  
  
  
  The lactulose-fed rats had a better colonization resistance. Translocation was reduced by dietary calcium, whereas lactulose was ineffective. In addition, calcium supplementation stimulated lactulose fermentation, reversed the lactulose-induced increase in cytotoxicity of faecal water and normalized growth and faecal consistency.
  
  
  
  The combination of dietary lactulose and calcium phosphate is protective against Salmonella infection.
authors.affiliation: Dept. of Nutrition, Netherlands Institute for Dairy Research, Ede, The Netherlands.
authors.forename: I
authors.initials: I
authors.lastname: Bovee-Oudenhoven
authors.forename: R
authors.initials: R
authors.lastname: Van der Meer
mesh_terms: D000818:Animals; D018988:Bacterial Translocation; D002130:Calcium Phosphates / Q000627:therapeutic use*; D002136:Calcium, Dietary / Q000627:therapeutic use*; D005243:Feces / Q000737:chemistry / Q000382:microbiology; D005285:Fermentation; D005765:Gastrointestinal Agents / Q000627:therapeutic use*; D007792:Lactulose / Q000627:therapeutic use*; D051381:Rats; D012481:Salmonella Infections, Animal / Q000178:diet therapy / Q000517:prevention & control*; D012477:Salmonella enteritidis / Q000502:physiology; D013047:Specific Pathogen-Free Organisms
chemical_list: D002130:Calcium Phosphates; D002136:Calcium, Dietary; D005765:Gastrointestinal Agents; C485828:alpha-tricalcium phosphate; C485830:tetracalcium phosphate; D007792:Lactulose; C485838:calcium phosphate, monobasic, anhydrous; C020243:calcium phosphate; C485829:calcium phosphate, dibasic, anhydrous