Recurrence and relapse in geriatric depression: a review of risk factors and prophylactic treatment strategies.
An emerging body of epidemiologic data has substantiated that in younger and middle-aged populations, major depression may be characterized by early relapse, recurrence, and chronicity. Information regarding the prognosis of geriatric depression is less extensive. This article reviews the literature on the longitudinal outcome of major depression in older adults, with particular emphasis on the limited data on strategies for the pharmacologic and electroconvulsive prophylaxis of recurrent unipolar geriatric depression. Possible biological markers for relapse risk, derived from sleep electroencephalography, neuroendocrine tests, and neuroradiographic findings, are also discussed. Recommendations for the treatment and long-term follow-up of geriatric depression are presented.
Stoudemire
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Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia, USA.
D000368:Aged; D000928:Antidepressive Agents / Q000627:therapeutic use; D003072:Cognition Disorders / Q000150:complications; D003131:Combined Modality Therapy; D003704:Dementia / Q000150:complications; D003866:Depressive Disorder / Q000150:complications / Q000175:diagnosis* / Q000628:therapy*; D004565:Electroconvulsive Therapy; D006801:Humans; D011379:Prognosis; D012008:Recurrence; D012307:Risk Factors
D000928:Antidepressive Agents