[An evaluation of the immunotropic and hemopoietic effects of hyperbaric oxygenation as an experimental pathological model].
Apoptosis, programmed cell death, being a physiological process is manifested by degenerative changes of the cell structures. Augmentation of apoptosis or distributed receptor-signal interaction of the cells may be caused by the toxic products of radiolysis and cancerogenesis. Hyperbaric oxygenation (HBO) was used as a model resembling apoptosis. The parameter of the humoral immune response to different HBO regimens and correction of immunodepression by a carotene-tocopherol complex (CTC) were compared. The next stage in the study of the CTC antioxidant effect in gamma-radiation was determination of the extent of endogenous colony formation under the influence of different HBO regimens. A moderate immunodepressive effect of HBO was noted. Combination of CTC and HBO in small regimens induced a moderate immunostimulating and hemopoietic response. The suggested pathological model may be used in study of antioxidants. CTC showed hemopoietic and immunocorrective action.
Pogabalo
A V
AV
Kazantseva
N V
NV
Sergeev
A V
AV
Uteshev
B S
BS
D000276:Adjuvants, Immunologic / Q000627:therapeutic use; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D000975:Antioxidants / Q000627:therapeutic use; D017209:Apoptosis / Q000187:drug effects; D002338:Carotenoids / Q000627:therapeutic use; D004195:Disease Models, Animal; D004338:Drug Combinations; D004353:Drug Evaluation, Preclinical; D006410:Hematopoiesis / Q000187:drug effects; D006931:Hyperbaric Oxygenation / Q000009:adverse effects*; D007153:Immunologic Deficiency Syndromes / Q000097:blood / Q000188:drug therapy / Q000209:etiology* / Q000276:immunology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D014810:Vitamin E / Q000627:therapeutic use
D000276:Adjuvants, Immunologic; D000975:Antioxidants; D004338:Drug Combinations; D014810:Vitamin E; D002338:Carotenoids
Otsenka immunotropnogo i gemopoéticheskogo éffektov giperbaricheskoĭ oksigenatsii v kachestve éksperimental'noĭ patologicheskoĭ modeli.