title: Three dose-dependent stages of the effect of copper ions on functional activity of biological systems.
abstract: The dose-dependent effects of copper sulfate on the proliferation and functional activity of the genome of liver cells and of algae in vivo and the activity of RNA-polymerase and glucose-6-phosphatase and formation of malonic dialdehyde in vitro were investigated. Administration of various doses of copper sulfate causes a dose-dependent three-phase response of biological systems comprising a stimulation phase, a latent phase, and a phase of inhibition. The degree of manifestation of the three-phase response depends on the functional activity of the biological system. The consecutive dose-dependent binding of metal ions with components of cells forms the basis of the three-phase response to copper ions.
authors.affiliation: Biological Research Institute, Kharkov State University, Ukraine. bozhkov@geron.kharkov.ua
authors.forename: A I
authors.initials: AI
authors.lastname: Bozhkov
mesh_terms: D000818:Animals; D002708:Chlorella / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism; D003300:Copper / Q000008:administration & dosage* / Q000378:metabolism / Q000633:toxicity*; D019327:Copper Sulfate / Q000008:administration & dosage / Q000633:toxicity; D004247:DNA / Q000096:biosynthesis; D012321:DNA-Directed RNA Polymerases / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D015870:Gene Expression / Q000187:drug effects; D005952:Glucose-6-Phosphatase / Q000378:metabolism; D066298:In Vitro Techniques; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D014176:Protein Biosynthesis; D051381:Rats; D017208:Rats, Wistar
chemical_list: D003300:Copper; D004247:DNA; D012321:DNA-Directed RNA Polymerases; D005952:Glucose-6-Phosphatase; D019327:Copper Sulfate