Family history of autoimmune diseases in psychosis.
The mothers of 101 psychotic patients and 116 normal controls were interviewed using a semi-structured questionnaire designed to determine the presence or absence of autoimmune disorders in first degree relatives of the probands. Thyrotoxicosis and insulin-dependent diabetes mellitus were significantly more common in the relatives of the psychotic patients than in the control relatives; in particular thyrotoxicosis was more frequent in the mothers of patients (11%) than the mothers of controls (2.6%). None of the examined characteristics of the patients, including RDC-diagnosis, family history of psychosis, age at onset of psychosis and winter birth, was predictive of thyrotoxicosis and insulin-dependent diabetes mellitus in relatives.
Gilvarry
C M
CM
Department of Psychological Medicine, Institute of Psychiatry, London, UK.
Sham
P C
PC
Jones
P B
PB
Cannon
M
M
Wright
P
P
Lewis
S W
SW
Bebbington
P
P
Toone
B K
BK
Murray
R M
RM
D000293:Adolescent; D000328:Adult; D001327:Autoimmune Diseases / Q000453:epidemiology*; D003922:Diabetes Mellitus, Type 1 / Q000453:epidemiology; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D011618:Psychotic Disorders / Q000175:diagnosis*; D012559:Schizophrenia / Q000175:diagnosis*; D012565:Schizophrenic Psychology; D013971:Thyrotoxicosis / Q000453:epidemiology