Mastication of verruca vulgaris associated with esophageal papilloma: HPV-45 sequences detected in oral and cutaneous tissues.
Human papillomaviruses (HPVs) are double-stranded, circular, epitheliotropic DNA viruses of which nearly 70 types have been identified. Specific HPV types exhibit a predilection to infect certain sites; however, occurrence is not unique or restricted to these sites. HPV typing may also be helpful in determining the oncogenic potential of HPV lesions. The most common HPV types, 6 and 11, are associated with benign mucosal lesions, whereas types 18, 16, 31, and 33 are thought to confer a high rate of malignant transformation. We describe a patient with both palmar verrucae and esophageal papillomatosis that proved to be HPV type 45 by polymerase chain reaction. HPV 45 has a high homology to HPV 18 and is a member of the relatively new "high-risk" mucosal HPV family in terms of cervical oncogenic potential. To our knowledge, HPV 45 has never been reported in cutaneous warts or esophageal lesions.
Ratoosh
S L
SL
Department of Dermatology, University of Texas Medical School at Houston, USA.
Glombicki
A P
AP
Lockhart
S G
SG
Rady
P L
PL
Chin
R
R
Arany
I
I
Hughes
T K
TK
Tyring
S K
SK
D004279:DNA, Viral / Q000032:analysis; D004938:Esophageal Neoplasms / Q000150:complications / Q000473:pathology / Q000821:virology*; D005260:Female; D005385:Fingers; D006801:Humans; D008875:Middle Aged; D009055:Mouth / Q000821:virology*; D010212:Papilloma / Q000150:complications / Q000473:pathology / Q000821:virology*; D027383:Papillomaviridae / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000473:pathology / Q000821:virology*; D012867:Skin / Q000821:virology*; D014412:Tumor Virus Infections / Q000473:pathology / Q000821:virology*; D014860:Warts / Q000150:complications / Q000473:pathology / Q000821:virology*
D004279:DNA, Viral