title: Elevated serum angiotensin converting enzyme levels in metastatic ovarian dysgerminoma.
abstract: A case of a 32-year-old XY genotype female is described, presenting with mediastinal and abdominal lymphadenopathy and associated with an elevated serum angiotensin I converting enzyme (SACE) level. Lymph node histology showed a malignant dysgerminoma of ovarian origin. Combined chemotherapy led to a radiological regression of the lymphadenopathy and coincided with a decrease in SACE concentration. The authors suggest that SACE may be a marker for disseminated germinoma tumours and may be useful for monitoring treatment.
authors.affiliation: Cork University Hospital, Ireland.
authors.forename: T P
authors.initials: TP
authors.lastname: Cotter
authors.forename: N P
authors.initials: NP
authors.lastname: Kealy
authors.forename: P F
authors.initials: PF
authors.lastname: Duggan
authors.forename: A
authors.initials: A
authors.lastname: Curtain
authors.forename: C P
authors.initials: CP
authors.lastname: Bredin
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000097:blood*; D012734:Disorders of Sex Development / Q000150:complications / Q000235:genetics; D004407:Dysgerminoma / Q000201:enzymology / Q000556:secondary* / Q000628:therapy; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D010051:Ovarian Neoplasms / Q000473:pathology*; D007703:Peptidyl-Dipeptidase A / Q000097:blood*
chemical_list: D014408:Biomarkers, Tumor; D007703:Peptidyl-Dipeptidase A