Exploring the potential of DNA vaccination.
DNA vaccines offer a unique means of stimulating and enhancing the immune response. Subjects are vaccinated with the gene for a particular antigen rather than with the antigen itself--the foreign protein that elicits the response is made intracellularly. This new type of gene therapy may not only extend the limits of immunoprotection but may also provide new insight into microbiologic and immunologic processes.
Cohen
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Robert Koch-Minerva Center for Research in Autoimmune Diseases, Weizmann Institute of Science, Rehovot, Israel.
Steinman
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D000818:Animals; D015316:Genetic Therapy / Q000379:methods / Q000639:trends*; D006801:Humans; D019444:Vaccines, DNA / Q000009:adverse effects / Q000276:immunology
D019444:Vaccines, DNA