Apoptosis as a proinflammatory event: what can we learn from bacteria-induced cell death?
Infection of cells by some pathogenic bacteria triggers host cell apoptosis. Bacteria-induced apoptosis appears to promote an inflammatory response that causes tissue damage and further bacterial colonization. Shigella pathogenesis offers a paradigm for the role of apoptosis in bacterial infections.
Zychlinsky
A
A
Dept of Microbiology, New York University School of Medicine, NY 10016, USA. zychlinsky@saturn.med.nyu.edu
Sansonetti
P J
PJ
D017209:Apoptosis / Q000276:immunology*; D001424:Bacterial Infections / Q000276:immunology; D004405:Dysentery, Bacillary / Q000453:epidemiology / Q000276:immunology*; D006801:Humans; D007249:Inflammation / Q000503:physiopathology*; D008264:Macrophages