Cutaneous and neurologic disease associated with HTLV-I infection.
Human T-lymphotropic virus type I (HTLV-I) is the etiologic agent of HTLV-I associated myelopathy (HAM)/tropical spastic paresis (TSP), and adult T-cell leukemia/lymphoma (ATLL). ATLL has been associated with HTLV-I in the southeastern United States. However, to our knowledge, no case reports of HAM/TSP in association with ATLL occurring in the United States have been described. We describe a 40-year-old black woman with a 10-year history of recalcitrant psoriasiform eruption and erythrodermic flares. Medical history is additionally significant for a 2-year history of HTLV-I-associated myelopathy and lower extremity spastic paresis. Polymerase chain reaction with Southern blot analysis was used to detect HTLV-I proviral genome from frozen skin biopsy specimens and peripheral blood mononuclear cells.
Sharata
H H
HH
Dermatology Clinic, University of Wisconsin Hospital and Clinics, Madison, USA.
Colvin
J H
JH
Fujiwara
K
K
Goldman
B
B
Hashimoto
K
K
D000328:Adult; D005260:Female; D015368:Human T-lymphotropic virus 1 / Q000302:isolation & purification; D006801:Humans; D016130:Immunophenotyping; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000150:complications* / Q000276:immunology / Q000821:virology; D015493:Paraparesis, Tropical Spastic / Q000150:complications* / Q000276:immunology / Q000821:virology; D016133:Polymerase Chain Reaction; D012867:Skin / Q000473:pathology / Q000821:virology; D012871:Skin Diseases / Q000150:complications*