[Tissue plasminogen activator and inhibitor and the severity and extensiveness of vascular lesions in peripheral atherosclerosis of the legs].
The aim of work was to study whether activity and antigen level of tissue plasminogen activator (t-PA) and activity of plasminogen activator inhibitor (PAI-1) were related to severity and extensiveness of vascular lesions in peripheral obliterative atherosclerotic disease (POAD). The study group consisted of 25 patients in II (13), III (10) and IV (2) degrees of disease acc. to Fontaine'a. In the blood t-PA activity and antigen and activity of PAI-1 were determined. In the patients with more severe POAD higher t-PA antigen and increased t-PA complexed with PAI-1 were observed. In patients with unisegmental POAD twice t-PA activity than in patients with polysegmental atherosclerotic lesions was detected.
Rość
D
D
Katedry i Zakładu Patofizjologii.
Zekanowska
E
E
Hryncewicz
W
W
Cwiklińska-Jurkowska
M
M
Jurkowski
P
P
Kotschy
M
M
D000368:Aged; D000941:Antigens / Q000032:analysis; D001161:Arteriosclerosis / Q000503:physiopathology*; D006801:Humans; D007866:Leg / Q000098:blood supply*; D008875:Middle Aged; D016491:Peripheral Vascular Diseases / Q000503:physiopathology*; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood*; D010959:Tissue Plasminogen Activator / Q000276:immunology*
D000941:Antigens; D017395:Plasminogen Activator Inhibitor 1; D010959:Tissue Plasminogen Activator
Tkankowy aktywator plazminogenu i inhibitor aktywatora plazminogenu a stopień zaawansowania i rozległość zmian naczyniowych w miazdzycy tetnic kończyn dolnych.