Scanning the genome with 1772 microsatellite markers in search of a bipolar disorder susceptibility gene.
Bipolar disorder affects approximately 1% of the population and there is evidence that genetic factors play an important role in the production of symptoms. We undertook a genetic linkage study for the discovery of a major locus conferring susceptibility for bipolar illness in an Old Order Amish pedigree. Our study took advantage of publicly available phenotypic and genotypic information, the latter as a byproduct of the human genome project effort. We present a genomic scan using 1772 polymorphic genetic markers and we suggest candidate genetic regions for harboring a bipolar disorder susceptibility gene.
Polymeropoulos
M H
MH
Laboratory of Genetic Disease Research, National Center for Human Genome Research, National Institutes of Health, Bethesda, MD, USA.
Schaffer
A A
AA
D001714:Bipolar Disorder / Q000235:genetics*; D002835:Christianity; D004276:DNA, Satellite / Q000235:genetics*; D005006:Ethnicity / Q000235:genetics*; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D005820:Genetic Testing; D005838:Genotype; D006801:Humans; D008126:Lod Score; D008297:Male; D010375:Pedigree; D010641:Phenotype
D004276:DNA, Satellite; D005819:Genetic Markers