title: Reproducibility of an esophageal biopsy sampling procedure in a high-incidence area for esophageal cancer in northern China.
abstract: The objective of this study was to evaluate the reproducibility of the biopsy sampling procedure in research on esophageal lesions. Biopsies were taken from the middle and lower thirds of the esophagus, one from each site, from 25 subjects in a high-incidence area for esophageal cancer in Xinye County of Henan Province, China. The biopsy sampling procedure was repeated on the same subjects 10 days later. When the biopsies were analyzed together and those with worse pathologies were used for diagnosis, 52% of the subjects had the same grade of lesions in the second biopsy examination, 32% had lower-grade lesions, and 16% had higher-grade lesions.
authors.affiliation: Laboratory for Cancer Research, Henan Medical University, Zhengzhou, Henan, China.
authors.forename: L D
authors.initials: LD
authors.lastname: Wang
authors.forename: Q
authors.initials: Q
authors.lastname: Zhou
authors.forename: R Y
authors.initials: RY
authors.lastname: Gou
authors.forename: Y
authors.initials: Y
authors.lastname: Xing
authors.forename: B C
authors.initials: BC
authors.lastname: Zhang
authors.forename: Q J
authors.initials: QJ
authors.lastname: Li
authors.forename: C S
authors.initials: CS
authors.lastname: Yang
mesh_terms: D000328:Adult; D001706:Biopsy / Q000379:methods*; D002455:Cell Division; D002467:Cell Nucleus / Q000648:ultrastructure; D016764:Cell Polarity; D002681:China; D004848:Epithelium / Q000473:pathology; D004938:Esophageal Neoplasms / Q000145:classification / Q000473:pathology*; D004947:Esophagus / Q000473:pathology*; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009092:Mucous Membrane / Q000473:pathology; D015203:Reproducibility of Results