DNA flow cytometry: a predictor of a high-risk group in cervical cancer.
We studied the relationship between the 5-year disease-free interval or the occurrence of distant metastases, and the flow cytometric nuclear DNA content in a group of 55 patients treated by radiation for squamous cell carcinoma of the uterine cervix, stages Ib-IIIb (FIGO). The diploid DNA content was associated with a better prognosis and a lower incidence of distant metastases, while aneuploid tumors tended to be prognostically unfavorable and had distant metastases more often. We consider the flow cytometric nuclear DNA content a prospective prognostic parameter in squamous cell carcinoma of the uterine cervix treated by radiotherapy.
Anton
M
M
Department of Obstetrics and Gynecology, Third University, Brno, Czech Republic.
Nenutil
R
R
Rejthar
A
A
Kopecny
J
J
Ptackova
B
B
Zaloudik
J
J
D000782:Aneuploidy; D002869:Chromosome Aberrations / Q000175:diagnosis; D025063:Chromosome Disorders; D004273:DNA, Neoplasm / Q000032:analysis*; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D009362:Neoplasm Metastasis; D016019:Survival Analysis; D002583:Uterine Cervical Neoplasms / Q000235:genetics* / Q000473:pathology
D004273:DNA, Neoplasm