Coagulation activation in extracorporeal hemodialysis.
The authors evaluated the behavior of protein C activity, factor X and factor VII coagulant activity and serum lipoprotein(a) before and after dialytic treatment in patients on maintenance hemodialysis. They observed depressed protein C activity that significantly (p < 0.005) increased and became normal immediately after hemodialysis while factor X and factor VII increased (p < 0.01; p < 0.05) despite heparinization together with amount of serum lipoprotein(a). In vitro incubation (30' at 37 degrees C) of uremic and healthy blood showed a decrease in serum lipoprotein(a) concentration. After heparin addition (final concentration 0.5 U/ml) lipoprotein(a) increased in the uremic blood only. The clinical and physiopathological implications of these results are discussed.
Camici
M
M
Clinical Medicines Institute I, Pisa University, Italy.
Evangelisti
L
L
Balestri
P
P
Cioni
L
L
Rindi
P
P
Sagripanti
A
A
Meriggioli
M
M
Giordani
R
R
D000328:Adult; D000368:Aged; D001777:Blood Coagulation; D001798:Blood Proteins / Q000032:analysis; D005167:Factor VII / Q000032:analysis*; D005170:Factor X / Q000032:analysis*; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000628:therapy; D017270:Lipoprotein(a) / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011486:Protein C / Q000032:analysis*; D006435:Renal Dialysis / Q000592:standards*; D014511:Uremia / Q000097:blood
D001798:Blood Proteins; D017270:Lipoprotein(a); D011486:Protein C; D005167:Factor VII; D005170:Factor X