title: A linkage map of the rat genome derived from three F2 crosses.
abstract: We report the construction of a dense linkage map of the rat genome integrating 767 simple sequence length polymorphism markers, combined over three crosses with high rates of polymorphism. F2 populations from WKY x S (n = 159), BN x S (n = 91), and BN x GK (n = 139) were selected and genotyped for combinations of microsatellite markers. The loci define 21 linkage groups corresponding to the 20 rat autosomal chromosomes and the X chromosome. The map spans a genetic length of 1998 cM. This combined linkage map should facilitate the advancement of genetic studies for a wide variety of rat models characterized for complex phenotypes.
authors.affiliation: Wellcome Trust Centre for Human Genetics, University of Oxford, UK. marie-therese.bihoreau@well.ox.ac.uk
authors.forename: M T
authors.initials: MT
authors.lastname: Bihoreau
authors.forename: D
authors.initials: D
authors.lastname: Gauguier
authors.forename: N
authors.initials: N
authors.lastname: Kato
authors.forename: G
authors.initials: G
authors.lastname: Hyne
authors.forename: K
authors.initials: K
authors.lastname: Lindpaintner
authors.forename: J P
authors.initials: JP
authors.lastname: Rapp
authors.forename: M R
authors.initials: MR
authors.lastname: James
authors.forename: G M
authors.initials: GM
authors.lastname: Lathrop
mesh_terms: D000818:Animals; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D008040:Genetic Linkage; D005819:Genetic Markers; D014644:Genetic Variation; D005828:Genetics, Population; D018895:Microsatellite Repeats; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D051381:Rats; D011918:Rats, Inbred SHR; D011919:Rats, Inbred Strains / Q000235:genetics*; D011921:Rats, Inbred WKY; D017208:Rats, Wistar; D014960:X Chromosome
chemical_list: D005819:Genetic Markers