title: Manic episodes in two patients treated with interferon alpha.
abstract: The authors report the assessment of 2 patients on interferon alpha (IFN-alpha) therapy for chronic myelogenous leukemia who developed manic symptoms long after IFN-alpha therapy had been initiated. These cases suggest that chronic IFN-alpha therapy may be associated with vulnerability for developing overt psychiatric symptoms, particularly in cases where the patient is experiencing psychosocial stress, and that the current definition of persistent adverse effects of IFN-alpha should be broadened to include the occurrence of manic episodes.
authors.affiliation: Department of Neuro-Oncology, University of Texas M. D. Anderson Cancer Center, Houston 77030, USA.
authors.forename: D
authors.initials: D
authors.lastname: Strite
authors.forename: A D
authors.initials: AD
authors.lastname: Valentine
authors.forename: C A
authors.initials: CA
authors.lastname: Meyers
mesh_terms: D000328:Adult; D001714:Bipolar Disorder / Q000139:chemically induced* / Q000188:drug therapy; D002998:Clonazepam / Q000627:therapeutic use; D003072:Cognition Disorders / Q000175:diagnosis; D018492:Dopamine Antagonists / Q000627:therapeutic use; D005260:Female; D018757:GABA Modulators / Q000627:therapeutic use; D006220:Haloperidol / Q000627:therapeutic use; D006801:Humans; D016898:Interferon-alpha / Q000009:adverse effects* / Q000627:therapeutic use; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D013315:Stress, Psychological / Q000523:psychology; D014888:Wechsler Scales
chemical_list: D018492:Dopamine Antagonists; D018757:GABA Modulators; D016898:Interferon-alpha; D002998:Clonazepam; D006220:Haloperidol