title: An energy sensor for control of energy intake.
abstract: Control of energy intake, either in response to changes in the energy content of food or in energy expenditures and storage, is based on the detection of a feedback signal generated in the processing of metabolic fuels for energy. Evidence from studies of the fructose analogue, 2,5-AM, indicates a sensor in liver responds to changes in intracellular ATP or some closely associated event and communicates this information to the brain via vagal afferent neurons. Such a mechanism could serve as the energy sensor which controls energy intake.
authors.affiliation: Monell Chemical Senses Center, Philadelphia, PA 19104, USA.
authors.forename: M I
authors.initials: MI
authors.lastname: Friedman
mesh_terms: D000818:Animals; D004435:Eating / Q000187:drug effects / Q000502:physiology*; D002149:Energy Intake / Q000502:physiology*; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000378:metabolism* / Q000502:physiology*; D008353:Mannitol / Q000031:analogs & derivatives / Q000494:pharmacology
chemical_list: D008353:Mannitol; C031765:2,5-anhydromannitol