title: Ploidy profile of morphologically normal squamous epithelium adjacent to high grade cervical intraepithelial neoplasia.
abstract: We have investigated the ploidy profile of morphologically normal mucosa adjacent to high grade CIN (n = 16) and also from normal cervix (n = 18). DNA ploidy was assessed using flow cytometry and image analysis. All cases were diploid by both modalities. Our results show that morphologically normal squamous mucosa has a stable ploidy profile even when it lies adjacent to high grade CIN. This finding supports the view that high grade CIN is a neoplastic expansion of transformed cells rather than the result of a field change effect.
authors.affiliation: Royal College of Surgeons in Ireland, Dublin, Republic of Ireland.
authors.forename: N
authors.initials: N
authors.lastname: McDermott
authors.forename: Y
authors.initials: Y
authors.lastname: Suliman
authors.forename: C B
authors.initials: CB
authors.lastname: Walsh
authors.forename: E W
authors.initials: EW
authors.lastname: Kay
authors.forename: B
authors.initials: B
authors.lastname: Curran
authors.forename: C
authors.initials: C
authors.lastname: Milburn
authors.forename: M
authors.initials: M
authors.lastname: Turner
authors.forename: W
authors.initials: W
authors.lastname: Prendiville
authors.forename: M
authors.initials: M
authors.lastname: Leader
mesh_terms: D004848:Epithelium / Q000473:pathology; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D011003:Ploidies; D002583:Uterine Cervical Neoplasms / Q000235:genetics* / Q000473:pathology; D002578:Uterine Cervical Dysplasia / Q000235:genetics* / Q000473:pathology