title: Prognostic value of histobiological factors (malignancy grading and AgNOR content) assessed at the invasive tumour front of oral squamous cell carcinomas.
abstract: Tumour cells at the invasive front of carcinomas have been found to differ substantially from the rest of tumour cells in a variety of human cancers. The present multivariate survival analysis of 94 oral squamous cell carcinomas (OSCCs) revealed that both the argyrophilic nucleolar organizer regions-associated protein (AgNOR) content of invading tumour cells and a multiparametric histopathological tumour front grade were significantly and independently associated with tumour-related death, irrespective of conventional Broders' grade and clinical stage of the tumours. High tumour front scores and AgNOR content at the invasive OSCC front thus seem to reflect increased malignant potential. Proliferative activity, assessed by standardized AgNOR analysis, most probably represents one of the biological features underlying the usefulness of evaluating the invasive tumour front.
authors.affiliation: Department of Cranio-Maxillofacial Surgery, University of Münster, Germany.
authors.forename: J
authors.initials: J
authors.lastname: Piffkò
authors.forename: A
authors.initials: A
authors.lastname: Bànkfalvi
authors.forename: D
authors.initials: D
authors.lastname: Ofner
authors.forename: M
authors.initials: M
authors.lastname: Bryne
authors.forename: D
authors.initials: D
authors.lastname: Rasch
authors.forename: U
authors.initials: U
authors.lastname: Joos
authors.forename: W
authors.initials: W
authors.lastname: Böcker
authors.forename: K W
authors.initials: KW
authors.lastname: Schmid
mesh_terms: D000704:Analysis of Variance; D002294:Carcinoma, Squamous Cell / Q000473:pathology* / Q000648:ultrastructure; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000473:pathology* / Q000648:ultrastructure; D015999:Multivariate Analysis; D009361:Neoplasm Invasiveness; D009697:Nucleolus Organizer Region / Q000473:pathology*; D011379:Prognosis; D016622:Silver Staining / Q000379:methods