In vitro activity of premafloxacin, a new extended-spectrum fluoroquinolone, against pathogens of veterinary importance.
The in vitro activity of premafloxacin against 673 veterinary pathogens was evaluated. Premafloxacin was equivalent to ciprofloxacin, enrofloxacin, and danofloxacin in activity against the gram-negative bacilli but was much more active (MIC for 90% of the strains tested [MIC90], 0.015 to 0.25 microg/ml) than the comparison antimicrobial agents (MIC90, 0.13 to 16.0 microg/ml) against the staphylococci, streptococci, and anaerobes tested.
Watts
J L
JL
Animal Health Discovery Research, Pharmacia & Upjohn, Inc., Kalamazoo, Michigan 49001, USA. jlwatts@am.pnu.com
Salmon
S A
SA
Sanchez
M S
MS
Yancey
R J
RJ
D000818:Animals; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000188:drug therapy / Q000662:veterinary*; D024841:Fluoroquinolones; D006090:Gram-Negative Bacteria / Q000187:drug effects / Q000472:pathogenicity; D006094:Gram-Positive Bacteria / Q000187:drug effects / Q000472:pathogenicity; D008826:Microbial Sensitivity Tests; D011758:Pyrroles / Q000627:therapeutic use*; D015363:Quinolones / Q000627:therapeutic use*
D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D011758:Pyrroles; D015363:Quinolones; C105016:premafloxacin