title: Elevated serum levels of S100 and survival in metastatic malignant melanoma.
abstract: Current reports suggest serum S100 as a prognostic marker for disease progression in advanced malignant melanoma. In this study, we assessed serum levels of S100 and multiple clinical factors in relation to overall survival in 99 patients with metastatic malignant melanoma seen at our institution between May 1990 and April 1996. For statistical analysis, we used both univariate and multivariate Cox proportional-hazards models. Elevated serum levels of S100 correlated with poor outcome in metastatic malignant melanoma (P < 0.0001), univariate analysis). Upon multivariate analysis, however, S100 added no information to known clinical prognostic parameters.
authors.affiliation: Department of Haematology and Oncology, Medizinische Hochschule Hannover, Germany.
authors.forename: J
authors.initials: J
authors.lastname: Buer
authors.forename: M
authors.initials: M
authors.lastname: Probst
authors.forename: A
authors.initials: A
authors.lastname: Franzke
authors.forename: S
authors.initials: S
authors.lastname: Duensing
authors.forename: J
authors.initials: J
authors.lastname: Haindl
authors.forename: M
authors.initials: M
authors.lastname: Volkenandt
authors.forename: F
authors.initials: F
authors.lastname: Wittke
authors.forename: R
authors.initials: R
authors.lastname: Hoffmann
authors.forename: A
authors.initials: A
authors.lastname: Ganser
authors.forename: J
authors.initials: J
authors.lastname: Atzpodien
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000097:blood / Q000401:mortality* / Q000556:secondary; D008297:Male; D008545:Melanoma / Q000097:blood / Q000401:mortality* / Q000556:secondary; D008875:Middle Aged; D015999:Multivariate Analysis; D011379:Prognosis; D016016:Proportional Hazards Models; D009418:S100 Proteins / Q000097:blood*; D012878:Skin Neoplasms / Q000097:blood / Q000401:mortality* / Q000473:pathology; D015996:Survival Rate
chemical_list: D009418:S100 Proteins