title: Outcome and lineage involvement in t(12;21) childhood acute lymphoblastic leukaemia.
abstract: The t(12;21)(p13;q22) translocation has been described recently as the most recurrent genetic lesion in paediatric acute lymphoblastic leukaemias (ALLs). It has also been associated with B-precursor lineage involvement and good outcome. We tested 51 diagnostic paediatric ALLs and found 11 cases with molecular evidence of the t(12;21). Interestingly, amongst t(12;21) positive patients, we report three cases with hybrid phenotype, and two cases showing an aggressive and fatal disease. Our data show that the t(12;21) does not represent an independent good-risk indicator. Long follow-ups and additional molecular investigations are needed to assess the prognostic and pathogenetic relevance of t(12;21) in childhood ALLs.
authors.affiliation: Ospedale San Luigi Gonzaga, Orbassano, Dipartimento di Scienze Pediatriche e dell'Adolescenza, University of Torino, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Lanza
authors.forename: G
authors.initials: G
authors.lastname: Volpe
authors.forename: G
authors.initials: G
authors.lastname: Basso
authors.forename: E
authors.initials: E
authors.lastname: Gottardi
authors.forename: E
authors.initials: E
authors.lastname: Barisone
authors.forename: M
authors.initials: M
authors.lastname: Spinelli
authors.forename: E
authors.initials: E
authors.lastname: Ricotti
authors.forename: V
authors.initials: V
authors.lastname: Cilli
authors.forename: F
authors.initials: F
authors.lastname: Perfetto
authors.forename: E
authors.initials: E
authors.lastname: Madon
authors.forename: G
authors.initials: G
authors.lastname: Saglio
mesh_terms: D019070:Cell Lineage; D002648:Child; D002675:Child, Preschool; D002881:Chromosomes, Human, Pair 12; D002891:Chromosomes, Human, Pair 21; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D008297:Male; D010641:Phenotype; D016133:Polymerase Chain Reaction; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics*; D011379:Prognosis; D014178:Translocation, Genetic