Analgesic response to stress is reduced in perinatally undernourished rats.
Stress-induced analgesia was evaluated in adult rats submitted early in life to a protein deprivation schedule. Rats were undernourished with a hypoproteic diet containing 80 g casein/kg diet from d 14 of gestation until 50 days of age. Rats were thereafter fed a balanced nonpurified diet until 140 days of age, when they were exposed to two stressors: forced swimming and acute restraint, after which the analgesic response was evaluated. In addition, the analgesic response induced by different morphine doses was determined in another group of rats. Basal latency was not different in deprived and control rats. Undernourished rats presented a significantly lower analgesic response in both stress situations. However, when the analgesic response induced by different morphine doses (1, 2, 4 and 8 mg/kg, s.c.) was assessed, a significantly higher response occurred in undernourished rats compared to control rats. This lower stress-induced analgesia in undernourished rats may account for the behavioral alterations attributed to early undernutrition.
Gutiérrez
A C
AC
Departamento de Farmacología, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Argentina.
Keller
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EA
D000701:Analgesics, Opioid / Q000494:pharmacology*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology; D018753:Diet, Protein-Restricted / Q000009:adverse effects; D004305:Dose-Response Relationship, Drug; D005260:Female; D007103:Immobilization / Q000502:physiology; D009020:Morphine / Q000494:pharmacology*; D010146:Pain / Q000178:diet therapy / Q000503:physiopathology*; D005082:Physical Exertion / Q000502:physiology; D011502:Protein-Energy Malnutrition / Q000503:physiopathology*; D051381:Rats; D017208:Rats, Wistar; D013312:Stress, Physiological / Q000209:etiology / Q000503:physiopathology*; D013997:Time Factors
D000701:Analgesics, Opioid; D009020:Morphine