Lactulose and renal failure.
The introduction of lactulose as a new therapeutic agent for treatment of hepatic encephalopathy was a major breakthrough in this field. It was hypothesized that lactulose might prevent postoperative renal impairment after biliary surgery in patients with obstructive jaundice. The presumable mechanism purported was the diminished endotoxinemia by lactulose. Unfortunately, such a reno-protective effect has not been shown conclusively until now in clinical studies. In chronic renal failure lactulose is known to promote fecal excretion of water, sodium, potassium, amonium, urea, creatinine and protons. Thus, lactulose could be useful for the treatment of chronic renal failure. However, compliance to the therapy represents a major problem.
Vogt
B
B
Dept. of Internal Medicine, University Hospital of Berne, Switzerland.
Frey
F J
FJ
D058186:Acute Kidney Injury / Q000188:drug therapy*; D000818:Animals; D002779:Cholestasis / Q000601:surgery; D005765:Gastrointestinal Agents / Q000627:therapeutic use*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000188:drug therapy*; D007792:Lactulose / Q000627:therapeutic use*; D011183:Postoperative Complications / Q000517:prevention & control
D005765:Gastrointestinal Agents; D007792:Lactulose