[The neuroprotective effect of GABA-ergic substances in cerebral ischemia].
The GABA precursor progabide, the GABA-aminotransferase inhibitor valproate, and the GABA receptor agonist baclofen increased the resistance of mice and rats to ischemia of the brain in two different modes. Both time and dose curves of the neuroprotective and hypothermal effects correlated in individual animals within a group, but there was no correlation for different series. Probably hypothermia is just one of the components in the mechanism of the neuroprotective effect of GABAergic compounds.
Kulinskiĭ
V I
VI
Mikhel'son
G V
GV
D000818:Animals; D001418:Baclofen / Q000627:therapeutic use*; D001831:Body Temperature / Q000187:drug effects; D002545:Brain Ischemia / Q000188:drug therapy* / Q000503:physiopathology; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D018682:GABA Agents / Q000627:therapeutic use*; D018755:GABA Agonists / Q000627:therapeutic use*; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors; D014635:Valproic Acid / Q000627:therapeutic use*; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000627:therapeutic use
D018682:GABA Agents; D018755:GABA Agonists; C017985:progabide; D005680:gamma-Aminobutyric Acid; D014635:Valproic Acid; D001418:Baclofen
Neĭroprotektornyĭ éffekt GAMKergicheskikh veshchestv pri ishemii golovnogo mozga.