title: Presence of adrenomedullin-like immunoreactivity in the human cerebrospinal fluid.
abstract: The presence of adrenomedullin-like immunoreactivity in the cerebrospinal fluid was studied by radioimmunoassay in 13 subjects with various neurological diseases. The concentrations of adrenomedullin-like immunoreactivity in the cerebrospinal fluid were 9.4 +/- 3.1 pmol/l (mean +/- SD, n = 13). Reverse-phase high performance liquid chromatography of the extract of the pooled cerebrospinal fluid showed that approximately 40% of the adrenomedullin-like immunoreactivity was chromatographically identical to human adrenomedullin (1-52). This is the first report that demonstrates the presence of adrenomedullin-like immunoreactivity in the human cerebrospinal fluid.
authors.affiliation: Department of Applied Physiology and Molecular Biology, Tohoku University School of Medicine, Miyagi, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Takahashi
authors.forename: M
authors.initials: M
authors.lastname: Sone
authors.forename: F
authors.initials: F
authors.lastname: Satoh
authors.forename: O
authors.initials: O
authors.lastname: Murakami
authors.forename: K
authors.initials: K
authors.lastname: Totsune
authors.forename: H
authors.initials: H
authors.lastname: Tanji
authors.forename: N
authors.initials: N
authors.lastname: Sato
authors.forename: H
authors.initials: H
authors.lastname: Ito
authors.forename: T
authors.initials: T
authors.lastname: Mouri
mesh_terms: D053607:Adrenomedullin; D000328:Adult; D000368:Aged; D002850:Chromatography, Gel; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009422:Nervous System Diseases / Q000134:cerebrospinal fluid; D010455:Peptides / Q000134:cerebrospinal fluid* / Q000276:immunology*; D011863:Radioimmunoassay; D014665:Vasodilator Agents / Q000134:cerebrospinal fluid / Q000276:immunology
chemical_list: D010455:Peptides; D014665:Vasodilator Agents; D053607:Adrenomedullin