title: Analysis of the large (L) protein gene of the porcine rubulavirus LPMV: identification of possible functional domains.
abstract: The complete nucleotide sequence of the porcine rubulavirus LPMV (La Piedad Michoacan virus) large (L) protein gene was determined and analysed. The L mRNA was found to span 6,786 nucleotides, containing one single large open reading frame (ORF), putatively encoding a polypeptide of 2,251 amino acids. By aligning the amino acid sequence of the LPMV L-protein with L-protein of a number of viruses belonging to the order mononegavirale, a high degree of similarity between the LPMV L-protein and other rubula virus L-proteins was demonstrated, extending through almost the whole protein. Additionally we could identify several regions as being highly conserved among all studied viruses of the order mononegavirale. The significance of these regions are discussed.
authors.affiliation: Department of Veterinary Microbiology, Swedish University of Agricultural Sciences, Uppsala, Sweden. Suenda@bmc.uu.se
authors.forename: M
authors.initials: M
authors.lastname: Svenda
authors.forename: M
authors.initials: M
authors.lastname: Berg
authors.forename: J
authors.initials: J
authors.lastname: Moreno-López
authors.forename: T
authors.initials: T
authors.lastname: Linné
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D001665:Binding Sites; D004279:DNA, Viral; D005814:Genes, Viral; D006801:Humans; D008969:Molecular Sequence Data; D010802:Phylogeny; D012328:RNA Viruses / Q000235:genetics; D019213:Rubulavirus / Q000145:classification / Q000235:genetics*; D017386:Sequence Homology, Amino Acid; D013552:Swine / Q000821:virology; D014764:Viral Proteins / Q000235:genetics*
chemical_list: D004279:DNA, Viral; C106937:L protein, porcine rubulavirus; D014764:Viral Proteins