title: Comparative study of papaverine plus phentolamine versus prostaglandin E1 in erectile dysfunction.
abstract: OBJECTIVE
  We compared the efficacy and short-term adverse effects of 1 ml. 30 mg./ml. papaverine plus 0.5 mg./ml. phentolamine versus 1 ml. 30 micrograms./ml. prostaglandin E1 in patients undergoing pharmacological erection testing.
  
  
  METHODS
  A total of 60 patients (mean age 58 years) with a history of sexual erectile dysfunction longer than 6 months was randomly classified into 6 groups to be tested 1 week apart with the 2 solutions and with placebo to evaluate erection response and short-term adverse effects.
  
  
  RESULTS
  Of the patients tested with papaverine plus phentolamine 54% responded with erections adequate for penetration, compared to 50% of those tested with prostaglandin E1 (p > 0.05). Prolonged erection occurred in 18% of patients tested with papaverine plus phentolamine and 15% of those tested with prostaglandin E1 (p > 0.05). Pain was reported by 15 and 35% of patients, respectively (p < 0.05).
  
  
  CONCLUSIONS
  One ml. 30 mg./ml. papaverine plus 0.5 mg./ml. phentolamine has the same efficacy and equal prolonged erection rate as 1 ml. 30 micrograms./ml. prostaglandin E1 but the latter agent induces significantly more pain.
authors.affiliation: Urology Division, Hospital Durand, Buenos Aires, Argentina.
authors.forename: A
authors.initials: A
authors.lastname: Bechara
authors.forename: A
authors.initials: A
authors.lastname: Casabé
authors.forename: G
authors.initials: G
authors.lastname: Chéliz
authors.forename: S
authors.initials: S
authors.lastname: Romano
authors.forename: H
authors.initials: H
authors.lastname: Rey
authors.forename: N
authors.initials: N
authors.lastname: Fredotovich
mesh_terms: D000328:Adult; D000368:Aged; D000527:Alprostadil / Q000008:administration & dosage* / Q000009:adverse effects; D004359:Drug Therapy, Combination; D006801:Humans; D018783:Impotence, Vasculogenic / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D010208:Papaverine / Q000008:administration & dosage* / Q000009:adverse effects; D017060:Patient Satisfaction; D010646:Phentolamine / Q000008:administration & dosage* / Q000009:adverse effects; D014665:Vasodilator Agents / Q000008:administration & dosage* / Q000009:adverse effects
chemical_list: D014665:Vasodilator Agents; D010208:Papaverine; D000527:Alprostadil; D010646:Phentolamine