Reduced toxicity and enhanced antitumor efficacy of betacyclodextrin plumbagin inclusion complex in mice bearing Ehrlich ascites carcinoma.
Inclusion complex of plumbagin was prepared with betacyclodextrin employing neutralization method. The toxicity of the drug was reduced and the antitumor efficacy was enhanced on complexation with betacyclodextrin.
Singh
U V
UV
College of Pharmaceutical Sciences, Manipal.
Udupa
N
N
D000042:Absorption; D000704:Analysis of Variance; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000627:therapeutic use* / Q000633:toxicity; D002273:Carcinogens / Q000378:metabolism* / Q000633:toxicity; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy* / Q000378:metabolism / Q000401:mortality; D003505:Cyclodextrins / Q000378:metabolism* / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D004337:Drug Carriers; D004357:Drug Synergism; D005260:Female; D007928:Lethal Dose 50; D051379:Mice; D008807:Mice, Inbred BALB C; D009285:Naphthoquinones / Q000008:administration & dosage / Q000627:therapeutic use* / Q000633:toxicity; D009368:Neoplasm Transplantation; D047392:beta-Cyclodextrins
D000972:Antineoplastic Agents, Phytogenic; D002273:Carcinogens; D003505:Cyclodextrins; D004337:Drug Carriers; D009285:Naphthoquinones; D047392:beta-Cyclodextrins; C031215:betadex; C014758:plumbagin