title: High prevalence of hepatitis G virus in bone marrow transplant recipients and patients treated for acute leukemia.
abstract: Hepatitis G virus (HGV) is a newly described virus that has been implicated in transfusion-associated hepatitis. The prevalence of HGV in a group of multitransfused patients with hematological malignancy was studied using a reverse transcription polymerase chain reaction technique. Transfusion histories and serum aspartate aminotransferase (AST) levels were recorded. HGV was detected in 29 of 60 (48%) patients. There was no difference in HGV positivity rates between those with normal AST levels and those with raised AST levels. Analysis of patients by treatment type showed that 20 of 33 (61%) patients who received a bone marrow transplantation procedure were HGV positive compared with 9 of 27 (33%) treated with conventional combination chemotherapy (P = .036) despite similar transfusion histories. There was no significant difference in HGV positivity between patients treated before the introduction of United Kingdom blood donor screening for hepatitis C virus antibody:18 of 39 (46%) and those treated after the introduction of screening 11 of 21 (52%). HGV infection appears to be extremely common in these patients; however, the clinical significance of these findings with respect to liver dysfunction is not yet clear.
authors.affiliation: Department of Haematology, Birmingham Heartlands and Solihull NHS Trust (Teaching), UK.
authors.forename: S J
authors.initials: SJ
authors.lastname: Skidmore
authors.forename: K E
authors.initials: KE
authors.lastname: Collingham
authors.forename: P
authors.initials: P
authors.lastname: Harrison
authors.forename: J R
authors.initials: JR
authors.lastname: Neilson
authors.forename: D
authors.initials: D
authors.lastname: Pillay
authors.forename: D W
authors.initials: DW
authors.lastname: Milligan
mesh_terms: D000208:Acute Disease; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001219:Aspartate Aminotransferases / Q000097:blood; D015415:Biomarkers; D001782:Blood Donors; D001803:Blood Transfusion / Q000592:standards; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D018067:Flaviviridae / Q000302:isolation & purification*; D019337:Hematologic Neoplasms / Q000150:complications / Q000628:therapy / Q000821:virology; D006526:Hepatitis C / Q000097:blood / Q000175:diagnosis / Q000517:prevention & control; D006525:Hepatitis, Viral, Human / Q000150:complications / Q000453:epidemiology* / Q000635:transmission; D006801:Humans; D007938:Leukemia / Q000150:complications / Q000628:therapy / Q000821:virology*; D008403:Mass Screening; D015995:Prevalence; D012367:RNA, Viral / Q000097:blood / Q000302:isolation & purification; D012189:Retrospective Studies; D014019:Tissue Donors; D065227:Transfusion Reaction; D006113:United Kingdom / Q000453:epidemiology
chemical_list: D015415:Biomarkers; D012367:RNA, Viral; D001219:Aspartate Aminotransferases