Efficacies of ofloxacin, rifampin, and clindamycin in treatment of Staphylococcus aureus abscesses and correlation with results of an in vitro assay of intracellular bacterial killing.
We studied the efficacies of ofloxacin, rifampin, and clindamycin in a Staphylococcus aureus abscess model and seven antimicrobial regimens in an intracellular killing assay. Ofloxacin plus rifampin was the most effective regimen in the abscess model, and rifampin and ofloxacin were the most active regimens in the intracellular killing assay.
Bamberger
D M
DM
University of Missouri-Kansas City School of Medicine, 64108-2792, USA.
Herndon
B L
BL
Dew
M
M
Chern
R P
RP
Mitchell
H
H
Summers
L E
LE
Marcus
R F
RF
Kim
S C
SC
Suvarna
P R
PR
D000038:Abscess / Q000188:drug therapy*; D000818:Animals; D000890:Anti-Infective Agents / Q000097:blood / Q000627:therapeutic use*; D000904:Antibiotics, Antitubercular / Q000097:blood / Q000627:therapeutic use*; D002981:Clindamycin / Q000097:blood / Q000627:therapeutic use*; D008826:Microbial Sensitivity Tests; D008954:Models, Biological; D015242:Ofloxacin / Q000097:blood / Q000627:therapeutic use*; D011817:Rabbits; D051381:Rats; D012293:Rifampin / Q000097:blood / Q000627:therapeutic use*; D013203:Staphylococcal Infections / Q000188:drug therapy*; D013211:Staphylococcus aureus / Q000187:drug effects
D000890:Anti-Infective Agents; D000904:Antibiotics, Antitubercular; D002981:Clindamycin; D015242:Ofloxacin; D012293:Rifampin