title: Inhibitory effects of quassinoid derivatives on Epstein-Barr virus early antigen activation.
abstract: Short-term in vitro assays for tumor promoters and antitumor promoters (Epstein-Barr virus activation test) were carried out for semisynthetic quassinoids (3-7), which were obtained by esterification of the C-15 OH group of deacetylated isobrucein-B (2). All the ester derivatives showed higher antitumor promoting activity than that of the potent compound 2. A compound containing a fluorinated aliphatic ester showed the highest potency.
authors.affiliation: Department of Interdisciplinary Studies on Natural Environment, Faculty of Integrated Arts and Sciences, Hiroshima University, Higashi-Hiroshima, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Rahman
authors.forename: N
authors.initials: N
authors.lastname: Fukamiya
authors.forename: N
authors.initials: N
authors.lastname: Ohno
authors.forename: H
authors.initials: H
authors.lastname: Tokuda
authors.forename: H
authors.initials: H
authors.lastname: Nishino
authors.forename: K
authors.initials: K
authors.lastname: Tagahara
authors.forename: K H
authors.initials: KH
authors.lastname: Lee
authors.forename: M
authors.initials: M
authors.lastname: Okano
mesh_terms: D000956:Antigens, Viral / Q000187:drug effects* / Q000276:immunology; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000494:pharmacology; D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology; D005900:Glaucarubin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D004854:Herpesvirus 4, Human; D036702:Quassins; D014407:Tumor Cells, Cultured; D014775:Virus Activation / Q000187:drug effects
chemical_list: D000956:Antigens, Viral; D000972:Antineoplastic Agents, Phytogenic; D000998:Antiviral Agents; C033305:Epstein-Barr virus early antigen; D036702:Quassins; C076339:isobrucein B; D005900:Glaucarubin