title: Isometric handgrip exercise increases endothelin-1 plasma levels in patients with chronic congestive heart failure.
abstract: This study demonstrated an immediate and short-lasting endothelin-1 release in the circulation of patients with severe chronic congestive heart failure during isometric handgrip exercise, but not in normal subjects. Our data suggest that endothelin-1 levels may increase transiently during daily physical activity, thus contributing to progressive deterioration of left ventricular function.
authors.affiliation: II Cattedra di Cardiologia, Istituto di Chirurgia del Cuore e Grossi Vasi, Università La Sapienza, Rome, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Mangieri
authors.forename: G
authors.initials: G
authors.lastname: Tanzilli
authors.forename: F
authors.initials: F
authors.lastname: Barillà
authors.forename: M
authors.initials: M
authors.lastname: Ciavolella
authors.forename: G
authors.initials: G
authors.lastname: Serafini
authors.forename: M
authors.initials: M
authors.lastname: Nardi
authors.forename: F
authors.initials: F
authors.lastname: Mangiaracina
authors.forename: G
authors.initials: G
authors.lastname: Scibilia
authors.forename: L J
authors.initials: LJ
authors.lastname: Dell'Italia
authors.forename: P P
authors.initials: PP
authors.lastname: Campa
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D002908:Chronic Disease; D019332:Endothelin-1 / Q000097:blood*; D015444:Exercise / Q000502:physiology*; D018737:Hand Strength / Q000502:physiology*; D006333:Heart Failure / Q000503:physiopathology*; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D016277:Ventricular Function, Left / Q000502:physiology
chemical_list: D019332:Endothelin-1