Genetic factors as predictors for desmopressin treatment success.
The significance of a positive family history in predicting responsiveness to desmopressin (DDAVP) treatment was evaluated in 71 children with nocturnal enuresis. A good response to treatment was recorded in 91% of those children with a positive family history compared with only 7% of those with a negative family history. A review of the published literature further supports the predictive value of a positive family history and also confirms the importance of a broad definition for family history-including persistent nocturia. The importance of defining the family history is also discussed in terms of response to some other therapies for nocturnal enuresis.
Hogg
R J
RJ
Columbia Children's Hospital at Medical City, Dallas, Texas, USA.
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D003894:Deamino Arginine Vasopressin / Q000627:therapeutic use*; D004775:Enuresis / Q000188:drug therapy* / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D010375:Pedigree; D011237:Predictive Value of Tests; D012076:Renal Agents / Q000627:therapeutic use*; D016896:Treatment Outcome
D012076:Renal Agents; D003894:Deamino Arginine Vasopressin