Disseminated Histoplasma capsulatum infection presenting as genital ulcerations.
BACKGROUND
Histoplasma capsulatum infection in adults is most often subclinical but can result in disseminated disease with weight loss, fever, hepatosplenomegaly, and oropharyngeal ulcerations. Genital ulceration as the presenting sign of the disease has been reported rarely.


METHODS
A 63-year-old woman presented with multiple vaginal ulcerations due to chronic disseminated H capsulatum infection. Initial diagnosis was made by Papanicolaou and Giemsa-stained vulvar smears. Ketoconazole therapy resulted in clearing of the lesions in 5 weeks.


CONCLUSIONS
Chronic disseminated histoplasmosis is an insidious and potentially fatal disease that can present rarely as genital mucocutaneous ulcerations in women. Prompt presumptive diagnosis can be accomplished by examination of smears obtained by ulcer abrasion, permitting institution of appropriate therapy.
Smith
M B
MB
Department of Pathology, University of Texas Medical Branch, Galveston, USA.
Schnadig
V J
VJ
Zaharopoulos
P
P
Van Hook
C
C
D000935:Antifungal Agents / Q000627:therapeutic use; D002908:Chronic Disease; D005260:Female; D006660:Histoplasmosis / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D006801:Humans; D007654:Ketoconazole / Q000627:therapeutic use; D008875:Middle Aged; D065006:Papanicolaou Test; D012883:Skin Ulcer / Q000382:microbiology*; D014623:Vaginal Diseases / Q000382:microbiology*; D014626:Vaginal Smears; D014845:Vulvar Diseases / Q000382:microbiology*
D000935:Antifungal Agents; D007654:Ketoconazole