title: Increasing toxoplasma seropositivity in women with bad obstetric history and in newborns.
abstract: BACKGROUND
  Most infants with congenital Toxoplasma gondii infection have no symptoms at birth but few may develop retinal diseases or neurological abnormalities later in life. The presence of significant titres of antitoxoplasma antibodies in women in the reproductive age group indirectly indicates that Toxoplasma gondii is the cause of such congenital abnormalities and also sporadic abortions in some women.
  
  
  METHODS
  We did a retrospective analysis of antitoxoplasma antibodies detected by indirect haemagglutination assay, in women with bad obstetrical history and in newborns clinically suspected of congenital toxoplasmosis during 1981-91.
  
  
  RESULTS
  A significant increase in seropositivity in women and newborns was seen during 1989-91 as compared to 1981-88. More seropositive patients were recorded between April-June and October-December. However, no significant correlation could be observed between rising incidence of seropositivity and the seasonal distribution or age of women.
  
  
  CONCLUSIONS
  Epidemiological studies are required to ascertain the reason for the increasing trend of toxoplasma seropositivity and to suggest appropriate control strategies as it is possible to prevent congenital infection.
authors.affiliation: Postgraduate Institute of Medical Education and Research, Chandigarh, India.
authors.forename: P
authors.initials: P
authors.lastname: Sharma
authors.forename: I
authors.initials: I
authors.lastname: Gupta
authors.forename: N K
authors.initials: NK
authors.lastname: Ganguly
authors.forename: R C
authors.initials: RC
authors.lastname: Mahajan
authors.forename: N
authors.initials: N
authors.lastname: Malla
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D000913:Antibodies, Protozoan / Q000097:blood; D003906:Developing Countries; D005260:Female; D006801:Humans; D007194:India / Q000453:epidemiology; D007231:Infant, Newborn; D011247:Pregnancy; D015597:Pregnancy Complications, Parasitic / Q000453:epidemiology* / Q000276:immunology; D018566:Pregnancy, High-Risk; D012189:Retrospective Studies; D014122:Toxoplasma / Q000276:immunology; D014123:Toxoplasmosis / Q000453:epidemiology* / Q000276:immunology; D014125:Toxoplasmosis, Congenital / Q000453:epidemiology* / Q000276:immunology
chemical_list: D000913:Antibodies, Protozoan