Diurnal blood pressure rhythm in hypertensives with parental history of stroke.
To investigate whether the lack of nocturnal decline of blood pressure (nondipper) is a primary cause of stroke or a secondary abnormality due to stoke, we examined the relation between the blood pressure variation and parental history of stroke in 110 hypertensive patients. In nondippers (n = 54), the frequency of positive parental history of stroke was significantly higher than in dippers (n = 56) (53.7% v 33.9%, chi2 = 4.37, P = .0366). We observed a significant increase in the incidence of positive parental history of stroke in nondippers, suggesting that some genetic factors may regulate blood pressure profiles before stroke develops.
Maeda
Y
Y
Department of Cardiology, Jichi Medical School, Minamikawachi, Tochigi, Japan.
Ikeda
U
U
Ebata
H
H
Hojo
Y
Y
Nakagami
H
H
Shimada
K
K
D000368:Aged; D001794:Blood Pressure / Q000235:genetics*; D002561:Cerebrovascular Disorders / Q000235:genetics*; D002940:Circadian Rhythm; D005192:Family Health; D005260:Female; D006801:Humans; D006973:Hypertension / Q000235:genetics* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged