title: Distribution of types for six PCR-based loci; LDLR, GYPA, HBGG, D7S8, GC and HLA-DQA1 in central Pyrenees and Teruel (Spain).
abstract: The PCR-based DNA loci LDLR, GYPA, HBGG, D7S8, GC and HLA DQA1 are widely used in forensic casework analyses. Population data on the distribution of allele frequencies are desired to estimate the rarity of a DNA profile. We studied the allele distributions at these forensically important DNA markers in two Spanish populations (Central Pyrenees and Teruel). Results were in agreement with Hardy-Weinberg expectations. Furthermore, there was little evidence for departures from expectation of independence between loci within the two sample populations. Tests for homogeneity were carried out between the two Spanish populations and a U.S. Caucasian population.
authors.affiliation: Department of Legal Medicine, University of Zaragoza, Spain.
authors.forename: B
authors.initials: B
authors.lastname: Bell
authors.forename: B
authors.initials: B
authors.lastname: Budowle
authors.forename: B
authors.initials: B
authors.lastname: Martinez-Jarreta
authors.forename: Y
authors.initials: Y
authors.lastname: Casalod
authors.forename: E
authors.initials: E
authors.lastname: Abecia
authors.forename: M
authors.initials: M
authors.lastname: Castellano
mesh_terms: D000483:Alleles; D003550:Cystic Fibrosis / Q000235:genetics*; D005787:Gene Frequency; D008040:Genetic Linkage; D005819:Genetic Markers; D005838:Genotype; D005914:Globins / Q000235:genetics; D006021:Glycophorins / Q000235:genetics*; D006683:HLA-DQ Antigens / Q000235:genetics*; D059848:HLA-DQ alpha-Chains; D006455:Hemoglobins, Abnormal / Q000235:genetics*; D006801:Humans; D016133:Polymerase Chain Reaction; D011973:Receptors, LDL / Q000235:genetics*; D013030:Spain / Q000208:ethnology; D014809:Vitamin D-Binding Protein / Q000235:genetics*
chemical_list: D005819:Genetic Markers; D006021:Glycophorins; D006683:HLA-DQ Antigens; D059848:HLA-DQ alpha-Chains; C069050:HLA-DQA1 antigen; D006455:Hemoglobins, Abnormal; D011973:Receptors, LDL; D014809:Vitamin D-Binding Protein; D005914:Globins