title: Serum levels of soluble intercellular adhesion molecule-1 (ICAM-1) and the expression of ICAM-1 mRNA in uterine cervical cancer.
abstract: The purpose of this investigation was to evaluate the serum level of soluble intercellular adhesion molecule-1 (sICAM-1) in patients with squamous cell carcinoma of the cervix. Serum levels of sICAM-1 were measured by enzyme-linked immunosorbent assay in patients with cervical cancer (stage 0 through IV). Expression of mRNA in tumor tissues was evaluated by reverse transcriptase-polymerase chain reaction. Serum level of sICAM-1 in patients with advanced-stage (II-IV) or recurrent cervical cancer was found to be increased significantly. Expression of ICAM-1 mRNA was observed in most tumor tissues. Results suggest that sICAM-1 is shed from the cancerous tissue in patients with squamous cell carcinoma of the cervix.
authors.affiliation: Department of Obstetrics and Gynecology, Oita Medical University, Hasama-machi, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Nasu
authors.forename: H
authors.initials: H
authors.lastname: Narahara
authors.forename: Y
authors.initials: Y
authors.lastname: Etoh
authors.forename: Y
authors.initials: Y
authors.lastname: Kawano
authors.forename: Y
authors.initials: Y
authors.lastname: Hirota
authors.forename: I
authors.initials: I
authors.lastname: Miyakawa
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000097:blood / Q000378:metabolism*; D005260:Female; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000096:biosynthesis* / Q000097:blood* / Q000235:genetics; D009364:Neoplasm Recurrence, Local / Q000097:blood / Q000378:metabolism; D012333:RNA, Messenger / Q000096:biosynthesis; D002583:Uterine Cervical Neoplasms / Q000097:blood / Q000378:metabolism*
chemical_list: D012333:RNA, Messenger; D018799:Intercellular Adhesion Molecule-1