title: Primary malignant fibrous histiocytoma of the lung. Report of a case with bronchial brushing cytologic features.
abstract: BACKGROUND
  Malignant fibrous histiocytoma (MFH) arising primarily in the lungs is rare, and a preoperative diagnosis, as well as a surgical planning, is very important because of the tumor's propensity for vascular invasion and its low incidence of lymph node metastasis. The correct preoperative diagnosis of thoracic MFH is not easy to establish because the small fragments from needle and transbronchial biopsies are often inadequate for a conclusive histologic analysis. A preoperative bronchial brushing cytology suggestion of the diagnosis of primary MFH of the lungs may be helpful in such cases.
  
  
  METHODS
  A 37-year-old male presented with a large, irregular mass in the inferior and middle lobes on chest roentgenography as well as on computed tomography. Two bronchoscopies were performed, with the diagnosis of undifferentiated large cell carcinoma. After surgical resection a more sophisticated pathologic analysis, including immunohistochemical and ultrastructural studies, revealed a primary MFH of the lungs. Revision of the bronchial brushing cytology disclosed many spindle-shaped cells with a "comet" configuration, strongly suggestive of MFH.
  
  
  CONCLUSIONS
  The bronchial brushing cytology features of spindle-shaped and bizarre, multinucleated giant cells with a comet appearance may be the key to the cytomorphologic diagnosis of MFH.
authors.affiliation: Pulmonary Division, Hospital das Clínicas, Faculty of Medicine, University of São Paulo, Brazil.
authors.forename: C S
authors.initials: CS
authors.lastname: Barbas
authors.forename: V L
authors.initials: VL
authors.lastname: Capelozzi
authors.forename: T Y
authors.initials: TY
authors.lastname: Takagaki
authors.forename: C R
authors.initials: CR
authors.lastname: de Carvalho
authors.forename: J V
authors.initials: JV
authors.lastname: Barbas Filho
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000032:analysis; D003584:Cytological Techniques; D018219:Histiocytoma, Benign Fibrous / Q000737:chemistry / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D008175:Lung Neoplasms / Q000737:chemistry / Q000175:diagnosis* / Q000473:pathology; D008297:Male; D008854:Microscopy, Electron; D000514:alpha 1-Antichymotrypsin / Q000032:analysis
chemical_list: D015415:Biomarkers; D000514:alpha 1-Antichymotrypsin