[The comparative effect of melatonin and diazepam on shifts in the anxiety-phobia status of rats evoked by damage to the amygdala].
Disorders develop in the emotional sphere in the form of increased anxiety and fear in amygdalectomized rats. The pineal hormone melatonin and diazepam (in an equal dose of 0.1 mg/kg) alleviate the state of anxiety and fear in the animals. Despite some differences in behavioral activity, the effect of the drugs appears to be similar. This suggests that melatonin possesses anxiolytic properties which may be related to its effect on the function of the limbic structures.
Arushanian
E B
EB
Chernysheva
E M
EM
D000679:Amygdala / Q000293:injuries* / Q000502:physiology / Q000601:surgery; D000818:Animals; D014151:Anti-Anxiety Agents / Q000627:therapeutic use*; D001007:Anxiety / Q000188:drug therapy* / Q000209:etiology; D003975:Diazepam / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D008297:Male; D008550:Melatonin / Q000627:therapeutic use*; D010698:Phobic Disorders / Q000188:drug therapy* / Q000209:etiology; D051381:Rats
D014151:Anti-Anxiety Agents; D008550:Melatonin; D003975:Diazepam
Sravnitel'noe vliianie melatonina i diazepama na sdvigi v trevozhno-fobicheskom sostoianii krys, vyzvannye povrezhdeniem amigdaly.