title: Successful 6-month endurance training does not alter insulin-like growth factor-I in healthy older men and women.
abstract: BACKGROUND
  Lean body mass, strength, and endurance decline with advancing age, changes paralleled by declines in anabolic hormones, including growth hormone (GH) and insulin-like growth factor-I (IGF-I). Acute exercise has been shown to stimulate the GH/IGF-I axis, and long-term exercise increases GH. This study examined the effect of endurance training on IGF-I in healthy older men and women.
  
  
  METHODS
  Thirty-one healthy older men (66.9 +/- 1.0 yrs, mean +/- SEM) and 21 healthy older women (67.1 +/- 1.7 yrs) were randomized to either 3d/wk, 6-month endurance (ET3) or stretching/flexibility (SF3) protocols. Another group of 15 healthy older men (69.0 +/- 1.3 yrs) participated in a more intensive 5d/wk, 6-month endurance protocol (ET5). Before and after training, subjects were weight stabilized and participated in maximal exercise tolerance testing, body composition assessment, and fasting blood sampling.
  
  
  RESULTS
  ET3 training resulted in a significant increase (14%) in maximal aerobic power (VO2max), significant decreases in body weight (BW), fat mass (FM), and waist/hip ratio (WHR), and a significant increase in fat-free mass (FFM). No significant VO2max or body composition changes were observed in the SF3 group. For the ET5 group, a significant increase (22%) in VO2max and significant decrease in BW, FM, and WHR were observed. No significant changes in IGF-I were observed for any of the three groups. Pre- versus post-training IGF-I values were very stable (r = .86, p < .001) across subjects.
  
  
  CONCLUSIONS
  Within-subject basal levels of IGF-I in healthy seniors were extremely stable between pre- and post-training assessments. Two endurance training protocols of magnitudes sufficient to significantly increase aerobic capacity and decrease measures of body adiposity did not significantly increase basal levels of IGF-I in healthy older men and women.
authors.affiliation: Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, USA. vitiello@u.washington.edu
authors.forename: M V
authors.initials: MV
authors.lastname: Vitiello
authors.forename: C W
authors.initials: CW
authors.lastname: Wilkinson
authors.forename: G R
authors.initials: GR
authors.lastname: Merriam
authors.forename: K E
authors.initials: KE
authors.lastname: Moe
authors.forename: P N
authors.initials: PN
authors.lastname: Prinz
authors.forename: D D
authors.initials: DD
authors.lastname: Ralph
authors.forename: E A
authors.initials: EA
authors.lastname: Colasurdo
authors.forename: R S
authors.initials: RS
authors.lastname: Schwartz
mesh_terms: D000368:Aged; D000375:Aging / Q000097:blood*; D001823:Body Composition; D001824:Body Constitution; D001835:Body Weight; D005260:Female; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000032:analysis*; D008297:Male; D010101:Oxygen Consumption; D010806:Physical Education and Training; D010807:Physical Endurance; D012016:Reference Values
chemical_list: D007334:Insulin-Like Growth Factor I