title: Sustained remission of severe resistant autoimmune neutropenia with Campath-1H.
abstract: We report the course of a patient with severe autoimmune neutropenia in whom only transient responses occurred with corticosteroids, antilymphocyte globulin and granulocyte-colony stimulating factor, and who was resistant to treatment with azathioprine, cyclosporin and intravenous immunoglobulin. A 10 d course of intravenous Campath-1H monoclonal resulted in a sustained haematological response. The long-lasting effect of Campath-1H may be due to its remarkable ability to induce a profound and prolonged peripheral blood T lymphopenia.
authors.affiliation: Department of Haematology, St George's Hospital Medical School, London.
authors.forename: S B
authors.initials: SB
authors.lastname: Killick
authors.forename: J C
authors.initials: JC
authors.lastname: Marsh
authors.forename: G
authors.initials: G
authors.lastname: Hale
authors.forename: H
authors.initials: H
authors.lastname: Waldmann
authors.forename: S J
authors.initials: SJ
authors.lastname: Kelly
authors.forename: E C
authors.initials: EC
authors.lastname: Gordon-Smith
mesh_terms: D000074323:Alemtuzumab; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D061067:Antibodies, Monoclonal, Humanized; D000912:Antibodies, Neoplasm / Q000627:therapeutic use*; D001327:Autoimmune Diseases / Q000628:therapy*; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D007958:Leukocyte Count; D008875:Middle Aged; D009503:Neutropenia / Q000628:therapy*
chemical_list: D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D000912:Antibodies, Neoplasm; D000074323:Alemtuzumab