A pragmatic randomised comparison of transcervical resection of the endometrium with endometrial laser ablation for the treatment of menorrhagia.
OBJECTIVE
To compare endometrial laser ablation (ELA) with transcervical resection of the endometrium (TCRE) in the treatment of menorrhagia.


METHODS
Randomised controlled trial.


METHODS
Gynaecology department of a large teaching hospital.


METHODS
Women with menorrhagia due to dysfunctional uterine bleeding (n = 372) were randomly allocated to ELA (n = 188) or TCRE (n = 184).


METHODS
Operative complications, post-operative recovery, relief of menstrual and other symptoms, need for further surgical treatment, satisfaction with treatment after 6 and 12 months, and differential resource use.


RESULTS
TCRE was significantly quicker, with lower rates of fluid overload. Perioperative morbidity was low and similar in both groups. Outcome at 12 months was also similar: 72 women (45%) had either amenorrhoea or brown discharge in the ELA group compared with 71 (49%) in the TCRE group; 79 (49%) versus 68 (46%) had lighter periods. Thirty (16%) versus 36 (20%) had received further surgical treatment: 9 (5%) compared with 25 (14%) had had a hysterectomy and 21 (11%) versus 11 (6%) had received repeat ablation. Anxiety and depression, dysmenorrhoea and pre-menstrual symptoms were improved by both procedures and bladder symptoms were affected by neither. At 12 months 148 (90%) women in the ELA group and 140 (91%) women in the TCRE group were satisfied with their treatment. The estimated additional cost of ELA was Pound 145 per procedure.


CONCLUSIONS
At one year there was no clear difference in clinical outcome between ELA and TCRE. Both procedures were associated with low morbidity. ELA was the more costly procedure. Despite the need for further surgery for about one in six women, satisfaction rates were high following both ELA and TCRE.
Bhattacharya
S
S
Department of Obstetrics and Gynaecology, Aberdeen Royal Infirmary, UK.
Cameron
I M
IM
Parkin
D E
DE
Abramovich
D R
DR
Mollison
J
J
Pinion
S B
SB
Alexander
D A
DA
Grant
A
A
Kitchener
H C
HC
D000328:Adult; D001007:Anxiety / Q000209:etiology; D003863:Depression / Q000209:etiology; D005260:Female; D006801:Humans; D015907:Hysteroscopy; D053685:Laser Therapy / Q000009:adverse effects / Q000379:methods; D007902:Length of Stay; D008595:Menorrhagia / Q000601:surgery*; D017060:Patient Satisfaction