title: In vitro activity of premafloxacin, a new extended-spectrum fluoroquinolone, against pathogens of veterinary importance.
abstract: The in vitro activity of premafloxacin against 673 veterinary pathogens was evaluated. Premafloxacin was equivalent to ciprofloxacin, enrofloxacin, and danofloxacin in activity against the gram-negative bacilli but was much more active (MIC for 90% of the strains tested [MIC90], 0.015 to 0.25 microg/ml) than the comparison antimicrobial agents (MIC90, 0.13 to 16.0 microg/ml) against the staphylococci, streptococci, and anaerobes tested.
authors.affiliation: Animal Health Discovery Research, Pharmacia & Upjohn, Inc., Kalamazoo, Michigan 49001, USA. jlwatts@am.pnu.com
authors.forename: J L
authors.initials: JL
authors.lastname: Watts
authors.forename: S A
authors.initials: SA
authors.lastname: Salmon
authors.forename: M S
authors.initials: MS
authors.lastname: Sanchez
authors.forename: R J
authors.initials: RJ
authors.lastname: Yancey
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000188:drug therapy / Q000662:veterinary*; D024841:Fluoroquinolones; D006090:Gram-Negative Bacteria / Q000187:drug effects / Q000472:pathogenicity; D006094:Gram-Positive Bacteria / Q000187:drug effects / Q000472:pathogenicity; D008826:Microbial Sensitivity Tests; D011758:Pyrroles / Q000627:therapeutic use*; D015363:Quinolones / Q000627:therapeutic use*
chemical_list: D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D011758:Pyrroles; D015363:Quinolones; C105016:premafloxacin