title: Long-term results with cisapride in Parkinson's disease.
abstract: In this study, we examined whether there is a long-term effect of cisapride on colonic transit in Parkinson's disease. Twenty-five patients (11 women, 14 men; average age, 64.4 years; moderate symptoms) were studied and treated initially with cisapride, 5 mg, twice a day, and after the first week with cisapride, 10 mg, twice a day. Colonic transit was measured by radioopaque markers at various stages: after 1 week, 6 months, and 1 year. In untreated patients, transit took 131 h; after 1 week with cisapride, it was accelerated to 81 h. After 6 months, colonic transit time amounted to 99 and 118 h, respectively, after 1 year. Cisapride seems to be highly effective initially. After 6 months, a significant but reduced effect was seen, and after 1 year, only a small effect could be demonstrated.
authors.affiliation: Department of Neurology, Deutsche Klinik für Diagnostik, Wiesbaden, Germany.
authors.forename: W H
authors.initials: WH
authors.lastname: Jost
authors.forename: K
authors.initials: K
authors.lastname: Schimrigk
mesh_terms: D000368:Aged; D002400:Cathartics / Q000008:administration & dosage / Q000627:therapeutic use*; D020117:Cisapride; D003248:Constipation / Q000150:complications / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000150:complications*; D010528:Peristalsis / Q000187:drug effects; D010880:Piperidines / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D002400:Cathartics; D010880:Piperidines; D020117:Cisapride