[The role of the natriuretic hormone in the action of nifedipine and verapamil on the kidneys].
It was demonstrated in experiments on albino rats that under the effect of nifedipine and verapamil the increase in the excretion of electrolytes and water by the kidneys is accompanied with a rise in the natriuretic hormone (NUH) content in blood plasma and urine. This causes the renal effects of the drugs under study. The sensitivity of the kidneys to NUH increases in this case.
Filipets
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D000818:Animals; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D004231:Diuresis / Q000187:drug effects; D004232:Diuretics / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects* / Q000502:physiology; D045283:Natriuretic Agents / Q000032:analysis / Q000502:physiology*; D009543:Nifedipine / Q000494:pharmacology*; D051381:Rats; D014700:Verapamil / Q000494:pharmacology*
D002121:Calcium Channel Blockers; D004232:Diuretics; D045283:Natriuretic Agents; D014700:Verapamil; D009543:Nifedipine
Rol' natriĭureticheskogo gormona v deĭstvii nifedifina i verapamila na pochki.