Collagenase: a key enzyme in collagen turnover.
The primary agents responsible for cartilage and bone destruction in joint diseases are active proteinases that degrade collagen and proteoglycan. All four main classes of proteolytic enzymes are involved in either the normal turnover of connective tissue or its pathological destruction. These proteinases are made by different cells found within the joints. Both extracellular and intracellular pathways exist and individual enzymes can be inhibited by specific proteinaceous inhibitors that block their activity. Recent research has implicated the matrix metalloproteinases (MMPs) in many of the processes involved in joint diseases. The metalloproteinases are capable of degrading all components of the extracellular matrix. This family of proteinases contains a group of at least three collagenases that are capable of degrading native fibrillar collagen. Collagen degradation within joint disease is recognized as the irreversible step in the destruction of cartilage that leads to a failure in joint function. The collagenases are the enzymes necessary to initiate collagen turnover in normal connective tissue turnover and in disease.
Shingleton
W D
WD
Rheumatology Department, Medical School, Newcastle upon Tyne, U.K. W.D.Shingleton@ncl.ac.uk
Hodges
D J
DJ
Brick
P
P
Cawston
T E
TE
D000595:Amino Acid Sequence; D000818:Animals; D002356:Cartilage; D003094:Collagen / Q000378:metabolism*; D017364:Collagenases / Q000737:chemistry / Q000378:metabolism*; D003240:Connective Tissue Diseases / Q000201:enzymology; D005109:Extracellular Matrix / Q000378:metabolism; D006023:Glycoproteins; D006801:Humans; D008666:Metalloendopeptidases / Q000737:chemistry / Q000378:metabolism; D008969:Molecular Sequence Data; D011480:Protease Inhibitors; D019714:Tissue Inhibitor of Metalloproteinases
D006023:Glycoproteins; D011480:Protease Inhibitors; D019714:Tissue Inhibitor of Metalloproteinases; D003094:Collagen; D017364:Collagenases; D008666:Metalloendopeptidases