title: [Carcinosarcoma of the submaxillary gland].
abstract: Salivary gland carcinosarcoma is a rare neoplasm, with a poor prognosis, that should not be confused with the more common carcinoma ex-pleomorphic adenoma, in which the epithelial component alone is malignant. The authors report one case of carcinosarcoma of the submandibular gland, with no previous history of pre-existent tumor. The tumor exhibited two intermingled and very atypical cellular components, one undifferentiated and the other with a chondroid pattern. Immunostaining with epithelial markers in the undifferentiated area allowed to distinguish this tumor from salivary gland sarcomas. In addition, the positivity for EMA, vimentin, and S100 protein in the two predominant components suggested a common origin for the different tumoral cell types, and led to discuss the nomenclature and the still unclarified cellular origin of these tumors.
authors.affiliation: Service d'Anatomie Pathologique, Hôpital Boucicaut, Paris.
authors.forename: C
authors.initials: C
authors.lastname: Julié
authors.forename: D
authors.initials: D
authors.lastname: Aidan
authors.forename: S
authors.initials: S
authors.lastname: Arkwright
authors.forename: C
authors.initials: C
authors.lastname: Brocheriou
authors.forename: F
authors.initials: F
authors.lastname: Vildé
mesh_terms: D000368:Aged; D002296:Carcinosarcoma / Q000737:chemistry / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D011379:Prognosis; D013365:Submandibular Gland Neoplasms / Q000737:chemistry / Q000473:pathology*
vernacular_title: Carcinosarcome de la glande sous-maxillaire.