The effect of methamphetamine on histamine release in the rat hypothalamus.
In the present study, the effect of methamphetamine (MAP) on histamine (HA) release measured by in vivo brain microdialysis in the rat hypothalamus was investigated. Administration of MAP (3 mg/kg) significantly increase HA release from 40 to 160 min after the injection. This finding suggests that a moderate dose of MAP activates the hypothalamic HA neuron system, which may be related to effects of MAP on intrinsic biological rhythms.
Ito
C
C
Department of Psychiatry, Tohoku University School of Medicine, Sendai, Japan.
Onodera
K
K
Yamatodani
A
A
Watanabe
T
T
Sato
M
M
D000818:Animals; D000697:Central Nervous System Stimulants / Q000494:pharmacology*; D006636:Histamine Release / Q000187:drug effects*; D007031:Hypothalamus / Q000187:drug effects*; D008297:Male; D008694:Methamphetamine / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D000697:Central Nervous System Stimulants; D008694:Methamphetamine