Human immunodeficiency virus infection is a major risk factor for detection of human papillomavirus DNA in esophageal brushings.
The presence of human papillomavirus (HPV) DNA in esophageal brushings from human immunodeficiency virus (HIV)-seropositive hosts was investigated in a cross-sectional study. Oral and esophageal brushings from individuals scheduled for esophagogastroscopy (53 HIV-positive and 61 age-matched HIV-negative patients) were tested for the presence of HPV DNA by a consensus L1 polymerase chain reaction assay. HPV DNA was detected in esophageal brushings of 9 (17%) of the 53 HIV-seropositive patients and 0 of the 61 HIV-negative individuals. HPV-16 DNA was the most frequently detected. No proliferative mucosal lesion was noted in individuals with HPV-positive esophageal brushings. Cytological smears were done for 6 of the 9 patients with HPV-positive esophageal brushings, and epithelial atypia was recorded for 1. HIV infection and a history of genital herpes were strong independent predictors of HPV, suggesting that HPV is transmitted sexually in the esophagus.
Trottier
A M
AM
Département de Microbiologie et Immunologie, Université de Montréal,Québec, Canada.
Coutlée
F
F
Leduc
R
R
Ghattas
G
G
Toma
E
E
Allaire
G
G
Gaboury
L
L
Ghadirian
P
P
D017088:AIDS-Related Opportunistic Infections / Q000473:pathology / Q000821:virology*; D036022:Capsid Proteins; D003430:Cross-Sectional Studies; D004947:Esophagus / Q000473:pathology / Q000821:virology*; D005260:Female; D006801:Humans; D008297:Male; D009856:Oncogene Proteins, Viral / Q000235:genetics; D027383:Papillomaviridae / Q000235:genetics / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000473:pathology / Q000821:virology*; D012307:Risk Factors; D014412:Tumor Virus Infections / Q000473:pathology / Q000821:virology*
D036022:Capsid Proteins; D009856:Oncogene Proteins, Viral; C063317:L1 protein, Human papillomavirus type 16