title: A controlled trial of choleretic and hepatoprotective actions of Livzon and dehydrocholic acid in a model of obstructive jaundice in albino rats.
abstract: The authors have tried to examine the hepatoprotective and cholerectic action of a new indigenised drug, Livzon (Hind Chemicals Ltd., Kanpur, India) and compared its action to Decholin (casella-Riedel Pharma GmbH, Frankfurt, Germany), a known hepatoprotective and choleretic agent. Albino rats were chosen as the experimental animals. Obstructive jaundice was created by ligating the common bile ducts after taking liver biopsies. The animals were divided into three groups: (i) Control group-no drug was given, (ii) Livzon trial group, (iii) Decholin group. The animals were reoperated, liver biopsies were taken and histologically examined. The study confirmed the hepatoprotective and choleretic actions of Livzon and Decholin. However, Decholin was more of a choleretic, the Livzon was more hepatoprotective.
authors.affiliation: Department of Pediatric Surgery, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: J
authors.initials: J
authors.lastname: Ratan
authors.forename: S
authors.initials: S
authors.lastname: Rohatgi
authors.forename: D K
authors.initials: DK
authors.lastname: Gupta
authors.forename: S
authors.initials: S
authors.lastname: Ratan
mesh_terms: D000818:Animals; D001646:Bile / Q000502:physiology; D001652:Bile Ducts / Q000473:pathology; D002756:Cholagogues and Choleretics / Q000009:adverse effects / Q000627:therapeutic use*; D002779:Cholestasis / Q000188:drug therapy* / Q000201:enzymology / Q000473:pathology; D003685:Dehydrocholic Acid / Q000627:therapeutic use*; D016166:Free Radical Scavengers / Q000494:pharmacology; D008111:Liver Function Tests; D008862:Microsomes, Liver / Q000201:enzymology; D010936:Plant Extracts / Q000627:therapeutic use*; D051381:Rats
chemical_list: D002756:Cholagogues and Choleretics; D016166:Free Radical Scavengers; D010936:Plant Extracts; C107138:livzon; D003685:Dehydrocholic Acid