title: Mixed connective tissue disease in childhood: a nationwide retrospective study in Japan.
abstract: Sixty-six children with mixed connective tissue disease (MCTD) were analyzed by a nationwide prospective study. The diagnostic significance of Raynaud's phenomenon and positive anti-RNP antibody was confirmed, and additional symptoms including swelling of fingers, facial erythema, and polyarthralgia, and laboratory findings such as positive rheumatoid factor, hypergammaglobulinemia, and increased levels of myogenic enzymes, were variably positive. These clinical and laboratory characteristics of MCTD were critically different from those of systemic lupus erythematosus, indicating that MCTD is an independent entity of disease.
authors.affiliation: Department of Pediatrics, Yokohama City University School of Medicine, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Yokota
authors.forename: T
authors.initials: T
authors.lastname: Imagawa
authors.forename: S
authors.initials: S
authors.lastname: Katakura
authors.forename: S I
authors.initials: SI
authors.lastname: Itoh
authors.forename: T
authors.initials: T
authors.lastname: Mitsuda
authors.forename: S
authors.initials: S
authors.lastname: Fujikawa
authors.forename: Y
authors.initials: Y
authors.lastname: Aihara
mesh_terms: D000293:Adolescent; D002648:Child; D005260:Female; D006306:Health Surveys; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008947:Mixed Connective Tissue Disease / Q000175:diagnosis / Q000453:epidemiology*; D011446:Prospective Studies; D011795:Surveys and Questionnaires