[Increased urinary excretion of transforming growth factor beta and interleukin-6 in patients with diabetic nephropathy].
The purpose of the study was to assess TGF-beta and IL-6 urinary excretion (measured with EIA) in 12 IDDM patients (7 F, 5 M, age 20-49 yrs, mean = 33.08) with albuminuria or microalbuminuria. Control group consists of 27 IDDM patients (12 F, 15 M, age 24-59 yrs. mean = 39.5) without albuminuria or microalbuminuria. Urinary excretion of IL-6 was significantly higher (p < 0.05) in IDDM patients with albuminuria (mean = 7.43 +/- 8.29 pg/mg creatinine) than in control group (mean = 3.74 +/- 2.64 pg/mg creatinine). Urinary excretion of TGF-beta was also higher (but not significantly in IDDM patients with albuminuria or microalbuminuria (mean = 42.0 +/- 30.0 pg/mg creatinine) than in control group (mean = 27.0 +/- 20.0 pg/mg creatinine). The data indicate that IL-6 and TGF-beta could be involved in the development of diabetic nephropathy.
Królak
R
R
Instytutu Transplantologii A.M. w Warszawie.
Paczek
L
L
Rogala
H
H
Bartłomiejczyk
I
I
Gradowska
L
L
Korczak
D
D
Gaciong
Z
Z
D000328:Adult; D000419:Albuminuria; D015415:Biomarkers / Q000652:urine; D003922:Diabetes Mellitus, Type 1 / Q000652:urine*; D003928:Diabetic Nephropathies / Q000652:urine*; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000652:urine*; D008297:Male; D008875:Middle Aged; D016212:Transforming Growth Factor beta / Q000652:urine*
D015415:Biomarkers; D015850:Interleukin-6; D016212:Transforming Growth Factor beta
Wzrost wydzielania do moczu transformujacego czynnika wzrostu beta i interleukiny-6 w przebiegu nefropatii cukrzycowej.