title: Genes necessary for C. elegans cell and growth cone migrations.
abstract: The migrations of cells and growth cones contribute to form and pattern during metazoan development. To study the mechanisms that regulate cell motility, we have screened for C. elegans mutants defective in the posteriorly directed migrations of the canal-associated neurons (CANs). Here we describe 14 genes necessary for CAN cell migration. Our characterization of the mutants has led to three conclusions. First, the mutations define three gene classes: genes necessary for cell fate specification, genes necessary for multiple cell migrations and a single gene necessary for final positioning of migrating cells. Second, cell interactions between the CAN and HSN, a neuron that migrates anteriorly to a position adjacent to the CAN, control the final destination of the HSN cell body. Third, C. elegans larval development requires the CANs. In the absence of CAN function, larvae arrest development, with excess fluid accumulating in their pseudocoeloms. This phenotype may reflect a role of the CANs in osmoregulation.
authors.affiliation: Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA. Forrestr@mendel.berkeley.edu
authors.forename: W C
authors.initials: WC
authors.lastname: Forrester
authors.forename: G
authors.initials: G
authors.lastname: Garriga
mesh_terms: D000818:Animals; D001369:Axons / Q000502:physiology; D017173:Caenorhabditis elegans / Q000196:embryology / Q000235:genetics / Q000254:growth & development*; D016923:Cell Death; D002465:Cell Movement; D004625:Embryo, Nonmammalian / Q000166:cytology / Q000502:physiology; D004627:Embryonic Induction; D018507:Gene Expression Regulation, Developmental; D017238:Genes, Helminth; D007150:Immunohistochemistry; D007814:Larva; D007834:Lasers; D009154:Mutation; D009420:Nervous System / Q000196:embryology; D009474:Neurons / Q000166:cytology / Q000502:physiology*; D012701:Serotonin / Q000032:analysis; D013045:Species Specificity; D005680:gamma-Aminobutyric Acid / Q000032:analysis
chemical_list: D012701:Serotonin; D005680:gamma-Aminobutyric Acid