title: Regression of uterine low-grade smooth-muscle tumors metastatic to the lung after oophorectomy.
abstract: BACKGROUND
  Metastatic uterine low-grade smooth-muscle tumors may present with pulmonary symptoms and radiographic lung abnormalities consistent with metastatic neoplasms. Ovarian hormone stimulation of these smooth-muscle tumors has been suggested, but the role of surgical or medical oophorectomy has not been established in patients with metastatic disease.
  
  
  METHODS
  Two women with histologically confirmed uterine low-grade smooth-muscle tumors metastatic to the lung had progressive and complete tumor regression after oophorectomy and no further therapy.
  
  
  CONCLUSIONS
  Some uterine low-grade smooth-muscle tumors metastatic to the lung regress after oophorectomy. Removing ovarian hormone stimulation may result in complete tumor regression without the need for further therapy.
authors.affiliation: Gynecology Service, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.
authors.forename: N R
authors.initials: NR
authors.lastname: Abu-Rustum
authors.forename: J P
authors.initials: JP
authors.lastname: Curtin
authors.forename: M
authors.initials: M
authors.lastname: Burt
authors.forename: W B
authors.initials: WB
authors.lastname: Jones
mesh_terms: D000328:Adult; D003937:Diagnosis, Differential; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007889:Leiomyoma / Q000000981:diagnostic imaging / Q000601:surgery*; D007890:Leiomyosarcoma / Q000000981:diagnostic imaging / Q000556:secondary* / Q000601:surgery*; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary* / Q000601:surgery*; D010052:Ovariectomy; D011859:Radiography; D012074:Remission Induction; D014594:Uterine Neoplasms / Q000473:pathology*