The immunogenicity of Haemophilus influenzae: meningococcal protein conjugate vaccine in Polynesian and non-Polynesian New Zealand infants.
OBJECTIVE
To examine the comparative immunogenicity of the Haemophilus influenzae type b-meningococcal protein (PRP-OMP) conjugate vaccine in Polynesian and non-Polynesian New Zealand infants.


METHODS
Fifty-six Polynesian and 53 non-Polynesian infants aged 2-7 months recruited from primary health care settings in Auckland received a two-dose primary series of PRP-OMP. A sub-sample of 83 participants received a booster dose of PRP-OMP at 12-16 months of age. Anti-PRP antibody concentrations were measured in pre- and post-vaccination blood samples.


RESULTS
Antibody responses consistent with long-term protection (> or = 1.00 microgram/mL) were observed in 72, 85 and 95% of children following the first, second and booster doses.


CONCLUSIONS
Despite differences in disease epidemiology, PRP-OMP was highly immunogenic in Polynesian and non-Polynesian infants.
Ameratunga
S N
SN
Department of Paediatrics, School of Medicine, University of Auckland, New Zealand.
Lennon
D R
DR
Entwistle
B
B
Robinson
E
E
Ameratunga
R V
RV
D000917:Antibody Formation; D016009:Chi-Square Distribution; D003430:Cross-Sectional Studies; D005500:Follow-Up Studies; D006192:Haemophilus Infections / Q000453:epidemiology / Q000208:ethnology / Q000276:immunology* / Q000517:prevention & control; D018073:Haemophilus Vaccines / Q000276:immunology*; D006801:Humans; D007115:Immunization Schedule; D007223:Infant; D008137:Longitudinal Studies; D015999:Multivariate Analysis; D009520:New Zealand / Q000453:epidemiology / Q000208:ethnology; D011114:Polynesia / Q000208:ethnology
D018073:Haemophilus Vaccines