title: Primary adenocarcinoma, signet-ring, and transitional cell carcinoma of the bladder with penile metastasis.
abstract: This article reports a rare case of primary signet-ring cell carcinoma of the bladder with transitional cell and adenocarcinoma variants and metachronous metastases to the penis and lungs. This combination of lesions has not previously been reported. Together, they portend widespread dissemination and an early demise as is frequently the case with signet-ring cell carcinomas arising in other organs such as the breast and gastrointestinal tract. The optimal therapeutic intervention for this myriad of neoplasms with metastasis to the penis has yet to be ascertained because of the rarity of the lesions. Early diagnosis and an aggressive surgical approach appear to offer the best chance for quality survival and possible cure.
authors.affiliation: Department of Surgery, Alvin C. York Veterans Administration Medical Center, Murfreesboro, Tennessee, USA.
authors.forename: R A
authors.initials: RA
authors.lastname: Allen
authors.forename: H L
authors.initials: HL
authors.lastname: Bumpers
authors.forename: A P
authors.initials: AP
authors.lastname: Kennedy
authors.forename: S
authors.initials: S
authors.lastname: Parsh
authors.forename: D L
authors.initials: DL
authors.lastname: Mobley
authors.forename: E L
authors.initials: EL
authors.lastname: Hoover
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology*; D000368:Aged; D018279:Carcinoma, Signet Ring Cell / Q000473:pathology*; D002295:Carcinoma, Transitional Cell / Q000473:pathology*; D006801:Humans; D008175:Lung Neoplasms / Q000556:secondary; D008297:Male; D016609:Neoplasms, Second Primary / Q000473:pathology*; D010412:Penile Neoplasms / Q000556:secondary*; D001749:Urinary Bladder Neoplasms / Q000473:pathology*