Role of cholesterol in the regulation of renal phosphate transport.
The kidney plays a critical role in the regulation of inorganic phosphate (Pi) homeostasis through changes in the proximal tubular apical membrane Na-dependent Pi (Na/Pi) transport activity. In response to alterations in dietary Pi intake and during the aging process, changes in renal Na/Pi transport activity are inversely correlated with apical membrane cholesterol content. Cholesterol regulates Na/Pi transport activity by fluidity-dependent and fluidity-independent mechanisms, including regulation of Na/Pi protein transcription, synthesis, and trafficking to and from the plasma membrane.
Wang
H
H
Department of Medicine, The University of Texas Southwestern Medical Center at Dallas, Texas 75216, USA.
Zajicek
H
H
Kumar
V
V
Wilson
P
P
Levi
M
M
D000818:Animals; D002784:Cholesterol / Q000502:physiology*; D006801:Humans; D017136:Ion Transport; D007668:Kidney / Q000378:metabolism*; D010710:Phosphates / Q000378:metabolism*; D051381:Rats
D010710:Phosphates; D002784:Cholesterol