Metabolism of phenylethanolamines and 2-oxo-2-phenylethylamines in the rat.
1. The metabolism of a series of phenylethanolamines and 2-oxo-2-phenylethylamines was examined in vivo in the rat. 2. The urinary excretion of the corresponding mandelic acids was, in general, considerably greater for 2-oxo-2-phenylethylamines than for the corresponding phenylethanolamines. Of the putative metabolites of the former class of compounds only phenylglyoxals yielded mandelic acids.
Goodwin
B L
BL
Department of Chemical Pathology, Queen Charlotte's and Chelsea Hospital, London, UK.
Ruthven
C R
CR
Sandler
M
M
D000818:Animals; D004983:Ethanolamines / Q000737:chemistry / Q000378:metabolism*; D005260:Female; D008333:Mandelic Acids / Q000652:urine; D008995:Monoamine Oxidase / Q000378:metabolism*; D010627:Phenethylamines / Q000737:chemistry / Q000378:metabolism*; D010626:Phenylethyl Alcohol / Q000031:analogs & derivatives / Q000378:metabolism; D010658:Phenylglyoxal / Q000031:analogs & derivatives / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
D004983:Ethanolamines; D008333:Mandelic Acids; D010627:Phenethylamines; D008995:Monoamine Oxidase; D010626:Phenylethyl Alcohol; D010658:Phenylglyoxal