title: Evaluation of a decision support system for initiation and control of oral anticoagulation in a randomised trial.
abstract: OBJECTIVE
  To determine whether a computerised decision support system for initiation and control of oral anticoagulant treatment improves quality of anticoagulant control achieved by trainee doctors.
  
  
  METHODS
  Randomised controlled trial.
  
  
  METHODS
  District general hospital in North London.
  
  
  METHODS
  148 inpatients requiring start of warfarin treatment.
  
  
  METHODS
  Management by trainee doctors (to achieve therapeutic range of international normalised ratio of 2 to 3) with indirect assistance from computerised decision support system (intervention group) or without such assistance (control group).
  
  
  METHODS
  Median time to therapeutic range, stable dose, and first pseudoevent (excessive international normalised ratio after therapeutic range has been reached) and person time spent in the therapeutic range.
  
  
  RESULTS
  72 patients were randomised to the intervention group and 76 to control group. Median time to reach international normalised ratio of > or = 2 was not significantly different in the two groups (3 days). Median time to achieve a stable dose was significantly lower in intervention group than in controls (7 days v 9 days, P = 0.01) without excessive overtreatment or undertreatment with anticoagulant. Patients in intervention group spent greater proportion of time in therapeutic range, both as inpatients (59% v 52%) and outpatients (64% v 51%).
  
  
  CONCLUSIONS
  The computerised decision support system was safe and effective and improved the quality of initiation and control of warfarin treatment by trainee doctors.
authors.affiliation: Cardiovascular Department, Whittington Hospital, London.
authors.forename: B
authors.initials: B
authors.lastname: Vadher
authors.forename: D L
authors.initials: DL
authors.lastname: Patterson
authors.forename: M
authors.initials: M
authors.lastname: Leaning
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000925:Anticoagulants / Q000008:administration & dosage*; D002983:Clinical Competence; D003658:Decision Making, Computer-Assisted; D003661:Decision Support Techniques; D004360:Drug Therapy, Computer-Assisted; D005260:Female; D006767:Hospitals, District; D006769:Hospitals, General; D006801:Humans; D008131:London; D008297:Male; D008505:Medical Staff, Hospital / Q000592:standards*; D008875:Middle Aged; D011787:Quality of Health Care; D014859:Warfarin / Q000008:administration & dosage*
chemical_list: D000925:Anticoagulants; D014859:Warfarin