Gastrodin and p-hydroxybenzyl alcohol facilitate memory consolidation and retrieval, but not acquisition, on the passive avoidance task in rats.
Gastrodin (GAS) and p-hydroxybenzyl alcohol (HBA) which is an aglycone of gastrodin, are active ingredients of Gastrodia elata Blume. In this study, we attempted to investigate the effects of acute administration of GAS and HBA on learning and memory processes such as acquisition, consolidation and retrieval, on the passive avoidance task in rats; piracetam was used as a positive control. Scopolamine, impairing learning acquisition, shortened the step-through latency in the retention test in rats. GAS and HBA did not prolong the step-through latency induced by scopolamine in the passive avoidance task, but piracetam could prolong the step-through latency induced by scopolamine. Cycloheximide, impairing memory consolidation, shortened the step-through latency in the retention test in rats. GAS at 50 mg/kg, HBA at 5 mg/kg and piracetam at 100 mg/kg could prolong the step-through latency induced by cycloheximide in the passive avoidance task. Apomorphine, impairing memory retrieval, shortened the step-through latency in the retention test in rats. GAS at 5 mg/kg, HBA at 1 mg/kg and piracetam at 300 mg/kg could prolong the step-through latency induced by apomorphine in the passive avoidance task. From the above results, we concluded that the facilitating effects of HBA on learning and memory are better than those of GAS. In conclusion, GAS and HBA can improve cycloheximide- and apomorphine-induced amnesia, but not scopolamine-induced acquisition impairment in rats. Thus, GAS and HBA can facilitate memory consolidation and retrieval, but not acquisition. The facilitating effects of GAS and HBA are different from those of piracetam.
Hsieh
M T
MT
Institute of Chinese Pharmaceutical Sciences, China Medical College, Taichung, Taiwan, ROC.
Wu
C R
CR
Chen
C F
CF
D000818:Animals; D001058:Apomorphine / Q000037:antagonists & inhibitors / Q000494:pharmacology; D001362:Avoidance Learning / Q000187:drug effects*; D001592:Benzyl Alcohols / Q000494:pharmacology*; D003513:Cycloheximide / Q000494:pharmacology; D018491:Dopamine Agonists / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D004597:Electroshock; D005960:Glucosides / Q000494:pharmacology*; D006993:Hypnotics and Sedatives / Q000494:pharmacology*; D008297:Male; D008568:Memory / Q000187:drug effects*; D018727:Muscarinic Antagonists / Q000494:pharmacology; D018697:Nootropic Agents / Q000494:pharmacology; D010889:Piracetam / Q000494:pharmacology; D011500:Protein Synthesis Inhibitors / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012601:Scopolamine / Q000037:antagonists & inhibitors / Q000494:pharmacology
D001592:Benzyl Alcohols; D018491:Dopamine Agonists; D004365:Drugs, Chinese Herbal; D005960:Glucosides; D006993:Hypnotics and Sedatives; D018727:Muscarinic Antagonists; D018697:Nootropic Agents; D011500:Protein Synthesis Inhibitors; C018966:4-hydroxybenzyl alcohol; C045345:gastrodin; D003513:Cycloheximide; D012601:Scopolamine; D001058:Apomorphine; D010889:Piracetam