The cytoskeleton in mRNA localization and cell differentiation.
Asymmetric distribution of cytoplasmic proteins and messenger RNAs has been implicated in several instances of cell differentiation. Microtubules have been suggested to direct mRNA localization in Drosophila and Xenopus oocytes but motor proteins that might transport mRNAs have not yet been identified. Recent data imply that in Drosophila, Caenorhabditis elegans and budding yeast, proteins of the actin cytoskeleton, including unconventional myosins, play active roles in the segregation of differentiation factors and mRNAs.
Nasmyth
K
K
Research Institute of Molecular Pathology, Dr Bohr-Gasse 7, A-1030, Vienna, Austria. Nasmyth@nt.imp.univie.ac.at
Jansen
R P
RP
D008841:Actin Cytoskeleton / Q000502:physiology; D000199:Actins / Q000502:physiology; D000818:Animals; D001692:Biological Transport; D002451:Cell Compartmentation; D003599:Cytoskeleton / Q000502:physiology*; D004331:Drosophila melanogaster; D005786:Gene Expression Regulation; D008870:Microtubules / Q000502:physiology; D009218:Myosins / Q000502:physiology; D012333:RNA, Messenger / Q000378:metabolism*; D014404:Tubulin / Q000502:physiology
D000199:Actins; D012333:RNA, Messenger; D014404:Tubulin; D009218:Myosins