Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression.
Normal mammalian growth and development are highly dependent on the regulation of the expression and activity of the Myc family of transcription factors. Mxi1-mediated inhibition of Myc activities requires interaction with mammalian Sin3A or Sin3B proteins, which have been purported to act as scaffolds for additional co-repressor factors. The identification of two such Sin3-associated factors, the nuclear receptor co-repressor (N-CoR) and histone deacetylase (HD1), provides a basis for Mxi1/Sin3-induced transcriptional repression and tumour suppression.
Alland
L
L
Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, New York 10461, USA.
Muhle
R
R
Hou
H
H
Potes
J
J
Chin
L
L
Schreiber-Agus
N
N
DePinho
R A
RA
D016475:3T3 Cells; D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins; D004268:DNA-Binding Proteins / Q000502:physiology; D005656:Fungal Proteins / Q000502:physiology; D005786:Gene Expression Regulation; D016259:Genes, myc; D006655:Histone Deacetylases / Q000502:physiology*; D006801:Humans; D051379:Mice; D009687:Nuclear Proteins / Q000502:physiology*; D056971:Nuclear Receptor Co-Repressor 1; D011993:Recombinant Fusion Proteins / Q000235:genetics / Q000378:metabolism; D012097:Repressor Proteins / Q000502:physiology*; D012441:Saccharomyces cerevisiae / Q000235:genetics; D029701:Saccharomyces cerevisiae Proteins; D014157:Transcription Factors / Q000502:physiology*; D014158:Transcription, Genetic; D025521:Tumor Suppressor Proteins
D051792:Basic Helix-Loop-Helix Proteins; D004268:DNA-Binding Proteins; D005656:Fungal Proteins; D006655:Histone Deacetylases; D009687:Nuclear Proteins; D056971:Nuclear Receptor Co-Repressor 1; D011993:Recombinant Fusion Proteins; D012097:Repressor Proteins; D029701:Saccharomyces cerevisiae Proteins; D014157:Transcription Factors; D025521:Tumor Suppressor Proteins; C079440:MXI1 protein, human; C512788:Mxi1 protein, mouse; C539127:NCOR1 protein, human; C539128:Ncor1 protein, mouse; C094978:PAH2 protein, Pichia angusta; C071731:SIN3 protein, S cerevisiae