Presence of adrenomedullin-like immunoreactivity in the human cerebrospinal fluid.
The presence of adrenomedullin-like immunoreactivity in the cerebrospinal fluid was studied by radioimmunoassay in 13 subjects with various neurological diseases. The concentrations of adrenomedullin-like immunoreactivity in the cerebrospinal fluid were 9.4 +/- 3.1 pmol/l (mean +/- SD, n = 13). Reverse-phase high performance liquid chromatography of the extract of the pooled cerebrospinal fluid showed that approximately 40% of the adrenomedullin-like immunoreactivity was chromatographically identical to human adrenomedullin (1-52). This is the first report that demonstrates the presence of adrenomedullin-like immunoreactivity in the human cerebrospinal fluid.
Takahashi
K
K
Department of Applied Physiology and Molecular Biology, Tohoku University School of Medicine, Miyagi, Japan.
Sone
M
M
Satoh
F
F
Murakami
O
O
Totsune
K
K
Tanji
H
H
Sato
N
N
Ito
H
H
Mouri
T
T
D053607:Adrenomedullin; D000328:Adult; D000368:Aged; D002850:Chromatography, Gel; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009422:Nervous System Diseases / Q000134:cerebrospinal fluid; D010455:Peptides / Q000134:cerebrospinal fluid* / Q000276:immunology*; D011863:Radioimmunoassay; D014665:Vasodilator Agents / Q000134:cerebrospinal fluid / Q000276:immunology
D010455:Peptides; D014665:Vasodilator Agents; D053607:Adrenomedullin