The effect of the H2 antagonist cimetidine on the numbers of CD4+ and CD8+ cells in the nasal mucosa of patients with allergic rhinitis.
This paper reports the effects of the H2 antagonist cimetidine on the number of CD4+ and CD8+ cells in nasal mucosa and the IgE level of nasal secretions in patients with allergic rhinitis. The results showed the numbers of CD4+ cells were greater than the numbers of CD8+ cells in nasal mucosa, both in the patients with allergic rhinitis and normal subjects, but the ratio of CD4+:CD8+ cells was much higher in the patients with allergic rhinitis. After treatment with cimetidine locally for 4 weeks, the numbers of CD4+ cells fell and the numbers of CD8+ cells increased in the patients with allergic rhinitis. The high IgE level of nasal secretion of the patients with allergic rhinitis was much reduced after treatment with cimetidine. The results suggest that there are high numbers of CD4+ cells and lower numbers of CD8+ cells in the nasal mucosa and a high level of IgE in the nasal secretions of the patients with allergic rhinitis. Treatment with cimetidine locally may be of some value to relieve the clinical symptoms of allergic rhinitis.
Yang
P C
PC
Department of Otolaryngology, The First Affiliated Hospital, Shanxi Medical College, Taiyan, People's Republic of China.
Liu
T
T
Zhang
T Y
TY
Fan
D S
DS
D000281:Administration, Intranasal; D000293:Adolescent; D000328:Adult; D000336:Aerosols; D000911:Antibodies, Monoclonal; D018791:CD4 Lymphocyte Count / Q000187:drug effects; D016516:CD4-CD8 Ratio / Q000187:drug effects; D015496:CD4-Positive T-Lymphocytes / Q000187:drug effects*; D018414:CD8-Positive T-Lymphocytes / Q000187:drug effects*; D002927:Cimetidine / Q000008:administration & dosage / Q000627:therapeutic use*; D004396:Coloring Agents; D004311:Double-Blind Method; D005260:Female; D006635:Histamine H2 Antagonists / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis / Q000187:drug effects; D018655:Lymphocyte Count / Q000187:drug effects; D008297:Male; D009297:Nasal Mucosa / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism; D012221:Rhinitis, Allergic, Perennial / Q000188:drug therapy* / Q000276:immunology / Q000503:physiopathology
D000336:Aerosols; D000911:Antibodies, Monoclonal; D004396:Coloring Agents; D006635:Histamine H2 Antagonists; D007073:Immunoglobulin E; D002927:Cimetidine