title: Iodopropynyl butylcarbamate: a new contact allergen.
abstract: Iodopropynyl butylcarbamate (IPBC) has been used for years as a fungicide and bactericide for wood and paint preservation without any reports of cutaneous side-effects. During the last few years, it has entered cosmetic products and is temporarily permitted in the EU Cosmetics Directive in a use concentration of 0.1%. In the present study, we report our preliminary experience with patch testing consecutive contact dermatitis patients with IPBC. A patch test concentration of 0.1% seems appropriate for initial screening but deserves further evaluation. Among 311 consecutive patch test patients, 3 patients with a positive patch test to IPBC have been identified. Contact allergy is likely in at least 1 case, based on clinical history, exposure history, patch testing with dilution series, ROAT and chemical analysis.
authors.affiliation: Department of Dermatology, University of Copenhagen, Gentofte Hospital, Hellerup, Denmark.
authors.forename: L E
authors.initials: LE
authors.lastname: Bryld
authors.forename: T
authors.initials: T
authors.lastname: Agner
authors.forename: S C
authors.initials: SC
authors.lastname: Rastogi
authors.forename: T
authors.initials: T
authors.lastname: Menné
mesh_terms: D000328:Adult; D000368:Aged; D002219:Carbamates / Q000009:adverse effects*; D003358:Cosmetics / Q000009:adverse effects*; D003877:Dermatitis, Contact / Q000209:etiology*; D009783:Dermatitis, Occupational / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010150:Paint / Q000009:adverse effects; D011310:Preservatives, Pharmaceutical / Q000009:adverse effects*
chemical_list: D002219:Carbamates; D003358:Cosmetics; D011310:Preservatives, Pharmaceutical; C106572:3-iodo-2-propynylbutylcarbamate