title: Role of type-1 fimbriae in the pathogenesis of chronic pyelonephritis in relation to reactive oxygen species.
abstract: The role of type-1 fimbriae in the pathogenesis of chronic pyelonephritis was studied for two Escherichia coli strains. Although both strains produced a similar total oxidative burst of chemiluminescence in macrophages from uninfected mice, the extracellular oxidative burst was greater with the non-fimbriate mutant E. coli BH-5 than its type-1 fimbriate parent E. coli 31-B. Moreover, macrophages from mice infected with the non-fimbriate mutant gave a much greater oxidative burst when stimulated with latex particles than that given by macrophages from mice infected with the type-1 fimbriate parent. These results correlated with the degree of renal inflammation and scarring as measured by malondialdehyde formation. Hence, the role of type-1 fimbriae in the pathogenesis of chronic UTI although documented does not appear to be significant.
authors.affiliation: Department of Microbiology, Government Medical College, Chandigarh, India.
authors.forename: R
authors.initials: R
authors.lastname: Gupta
authors.forename: S
authors.initials: S
authors.lastname: Gupta
authors.forename: N K
authors.initials: NK
authors.lastname: Ganguly
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D002908:Chronic Disease; D004195:Disease Models, Animal; D004926:Escherichia coli / Q000472:pathogenicity* / Q000648:ultrastructure; D004927:Escherichia coli Infections / Q000378:metabolism / Q000382:microbiology*; D005260:Female; D010861:Fimbriae, Bacterial / Q000502:physiology*; D007668:Kidney / Q000737:chemistry; D008163:Luminescent Measurements; D017737:Macrophages, Peritoneal / Q000378:metabolism / Q000382:microbiology; D008315:Malondialdehyde / Q000032:analysis; D051379:Mice; D008807:Mice, Inbred BALB C; D011704:Pyelonephritis / Q000378:metabolism / Q000382:microbiology*; D017382:Reactive Oxygen Species / Q000378:metabolism*; D016897:Respiratory Burst
chemical_list: D017382:Reactive Oxygen Species; D008315:Malondialdehyde