Free radicals, atherosclerosis, ageing and related dysmetabolic pathologies: biochemical and molecular aspects.
In human ageing and with many pathologies correlated to the senile functional decay of cells, membrane damage often occurs in some organ or tissue, which provokes lipid peroxidation in the membrane and accelerates the disorder in structure and function of the membrane. When lipid peroxides accumulate sufficiently, they leak from the organ or tissue into the bloodstream and increase the lipid peroxide level in blood lipoproteins. The increased lipid peroxides in the blood attack the blood vessel and promote atherogenesis. This paper describes the possible involvement of free radicals in this damage, both to tissues and to blood vessels, which contributes to the senile functional decay of the tissues.
Cestaro
B
B
Dipartimento di Chimica e Biochimica Medica, Università di Milano, Italy.
Giuliani
A
A
Fabris
F
F
Scarafiotti
C
C
D000255:Adenosine Triphosphate / Q000096:biosynthesis; D000368:Aged; D000375:Aging / Q000502:physiology*; D001161:Arteriosclerosis / Q000503:physiopathology*; D001808:Blood Vessels / Q000503:physiopathology*; D002462:Cell Membrane / Q000378:metabolism; D002470:Cell Survival; D005609:Free Radicals / Q000009:adverse effects / Q000378:metabolism; D006801:Humans; D008659:Metabolic Diseases / Q000503:physiopathology; D008967:Molecular Biology; D018570:Risk Assessment
D005609:Free Radicals; D000255:Adenosine Triphosphate