Biclonal immunoglobulin M dysglobulinaemia: evolving aspects in a case of primary Sjögren's syndrome.
The observation of suggestive clinical symptoms in a patient suffering from a Gougerot-Sjögren syndrome led to a search for a cryoglobulin. Unusual physico-chemical features of this cryoglobulin were discovered, using standard electrophoresis, immunoelectrophoresis, immunofixation and electroimmunotransfer. The main unusual finding was that the cryoprecipitate was made up of a biclonal IgM kappa associated to polyclonal IgG. Therefore, we suggest that this new form of cryoglobulin be classified as a subtype IIb, thus distinguishing two subtypes in the usual classification.
Pontet
F
F
Service de Biochimie, Hôpital Lariboisière, Paris, France.
Halimi
C
C
Brocard
A
A
Delacour
T
T
D000368:Aged; D000911:Antibodies, Monoclonal / Q000097:blood / Q000737:chemistry; D003449:Cryoglobulinemia / Q000209:etiology / Q000276:immunology*; D003450:Cryoglobulins / Q000737:chemistry*; D005260:Female; D006801:Humans; D007122:Immunoelectrophoresis; D007075:Immunoglobulin M / Q000097:blood* / Q000737:chemistry; D012859:Sjogren's Syndrome / Q000209:etiology / Q000276:immunology*; D013997:Time Factors
D000911:Antibodies, Monoclonal; D003450:Cryoglobulins; D007075:Immunoglobulin M