title: Treatment of vascular disease caused by vibration.
abstract: Vascular diseases caused by vibration are treated by different methods. We ourselves applied in our patients subcutaneous injections of hot-spring gas, per os prazosin (postsynaptic blocker of alpha-sympathetic receptors) which except for its vasodilatory effect improves the rheologic qualities of blood). Subcutaneous injections of hot-spring gas were administered to 31 males aged 32 to 67 years (average 50.58 years) for 15 days, Prazosin VUFB to 12 males aged 33 to 64 years (average 47.8 years) for 28 days and pentoxifylline (Agapurin SPOFA) to 20 males aged 29 to 69 years (average 46.35 years) for 28 days. Simultaneous nervous disease caused by vibration was present in 12 patients, articular affections caused by vibration in 10 patients, and disease of peripheral nerves and joints in 16 patients. The subjective complaints were influenced mostly by hotspring gas, the cold water test by prazosin, the skin temperature and plethysmogram by pentoxifylline. When evaluating the number of favourably influenced indicators pentoxifylline is the most successful. Tolerance of all three methods proved to be good.
authors.affiliation: Department of Occupational Medicine, University Hospital Plzen, Czech Republic.
authors.forename: J
authors.initials: J
authors.lastname: Kohout
authors.forename: F
authors.initials: F
authors.lastname: Hůzl
authors.forename: H
authors.initials: H
authors.lastname: Bejcková
authors.forename: K
authors.initials: K
authors.lastname: Soukupová
mesh_terms: D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology / Q000627:therapeutic use; D000328:Adult; D000368:Aged; D012090:Cumulative Trauma Disorders / Q000150:complications / Q000209:etiology / Q000628:therapy*; D005740:Gases / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D007279:Injections, Subcutaneous; D008297:Male; D008875:Middle Aged; D010431:Pentoxifylline / Q000494:pharmacology / Q000627:therapeutic use; D016491:Peripheral Vascular Diseases / Q000150:complications / Q000209:etiology / Q000628:therapy*; D011224:Prazosin / Q000494:pharmacology / Q000627:therapeutic use; D014665:Vasodilator Agents / Q000494:pharmacology / Q000627:therapeutic use; D014732:Vibration / Q000009:adverse effects*
chemical_list: D000317:Adrenergic alpha-Antagonists; D005740:Gases; D014665:Vasodilator Agents; D010431:Pentoxifylline; D011224:Prazosin