title: Differences in aldehyde oxidase activity in cytosolic preparations of human and monkey liver.
abstract: This study presents data showing individual differences in aldehyde oxidase activity in human and monkey liver cytosols. When assayed with benzaldehyde as a substrate, a significant inter-subject variation in the activity was found in the human liver preparations. When assayed with N1-methylnicotinamide as a substrate, the inter-subject variation of the activity was also observed, but to a lesser extent compared with that of the activity with benzaldehyde. Similarly, variations in aldehyde oxidase activity were found in the monkey liver preparations when assayed with benzaldehyde or N1-methylnicotinamide. The present study suggested that at least two isozymes of aldehyde oxidase exist in the human liver preparations.
authors.affiliation: Institute of Pharmaceutical Science, Hiroshima University School of Medicine, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Sugihara
authors.forename: S
authors.initials: S
authors.lastname: Kitamura
authors.forename: K
authors.initials: K
authors.lastname: Tatsumi
authors.forename: T
authors.initials: T
authors.lastname: Asahara
authors.forename: K
authors.initials: K
authors.lastname: Dohi
mesh_terms: D000368:Aged; D042931:Aldehyde Oxidase; D000445:Aldehyde Oxidoreductases / Q000737:chemistry* / Q000378:metabolism; D000818:Animals; D001547:Benzaldehydes / Q000378:metabolism; D015153:Blotting, Western; D003600:Cytosol / Q000201:enzymology*; D005260:Female; D006801:Humans; D007527:Isoenzymes / Q000737:chemistry / Q000378:metabolism; D008099:Liver / Q000737:chemistry / Q000166:cytology / Q000201:enzymology*; D008253:Macaca mulatta; D008297:Male; D008875:Middle Aged; D009536:Niacinamide / Q000031:analogs & derivatives / Q000378:metabolism
chemical_list: D001547:Benzaldehydes; D007527:Isoenzymes; D009536:Niacinamide; D000445:Aldehyde Oxidoreductases; D042931:Aldehyde Oxidase; C032175:benzaldehyde; C008472:N-methylnicotinamide