Colon cancer in rats and diet in the Sonoran desert region of Mexico.
The role of dietary fiber in colon cancer is still not clear. Epidemiological studies suggest a protective role for high fiber intake. However the data suggest that the effects of fiber must be considered in the context of the total diet and its interactions with other dietary components. The typical Sonora diet is high in dietary fiber (7.8%) and the majority of this fiber (71%) is insoluble. Comparing the incidence of colon cancer in Sonora with its neighboring state of Arizona, in 1991, Sonora reported 40 cases of colon cancer, a population of 1,823,606, compared to 1432 for Arizona (3,763,322 inhabitants). The typical regional diet was evaluated for its protective effect in the development of colon cancer in rats injected with azoxymethane, AOM. The regional diet showed a tendency to protect against colon cancer, an incidence of 45% compared to 66% for the control diet, although this effect was not significant (p = 0.15). Further studies are needed to fully evaluate the diet and certain interactive dietary factors such as fat, quantity as well as type, protein, calcium and antioxidant nutrients.
Wyatt
C J
CJ
Instituto Mexicano del Seguro Social, Hospital General Regional N(o). 2, Hermosillo, Sonora, México.
Dorado
I
I
Valencia
M E
ME
Navarro
E
E
D000818:Animals; D001397:Azoxymethane / Q000009:adverse effects; D003110:Colonic Neoplasms / Q000139:chemically induced / Q000453:epidemiology / Q000517:prevention & control*; D004043:Dietary Fiber; D015994:Incidence; D008297:Male; D008800:Mexico; D051381:Rats; D017207:Rats, Sprague-Dawley
D004043:Dietary Fiber; D001397:Azoxymethane