The prostaglandin transporter is widely expressed in ocular tissues.
Prostaglandins (PGs) play important physiological and therapeutic roles in the eye. Our laboratory recently identified a novel PG transporter in the rat that we call "PGT" (Science 268:866, 1995). We have also recently cloned the human PGT cDNA (J Clin Invest 98:1142, 1996). To determine whether PGT might play a role in human ocular tissues, we performed Northern blot analysis of RNA obtained from human ocular tissues and from the nonpigmented ciliary epithelium cell line "ODM-2." PGT transcripts were clearly evident in all ocular tissues. Given that the functional profile of PGT expressed in vitro strongly suggests a role in PG uptake and degradation, the present results suggest that PGT may function in various regions of the human eye for purposes of terminating the signal(s) produced by locally-synthesized PGs.
Schuster
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Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA.
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Coca-Prados
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D000328:Adult; D017920:Antiporters / Q000096:biosynthesis* / Q000235:genetics; D015152:Blotting, Northern; D002924:Ciliary Body / Q000166:cytology / Q000378:metabolism; D003001:Cloning, Molecular; D004268:DNA-Binding Proteins / Q000096:biosynthesis* / Q000235:genetics; D004847:Epithelial Cells; D004848:Epithelium / Q000378:metabolism; D005123:Eye / Q000166:cytology / Q000378:metabolism*; D006801:Humans; D017403:In Situ Hybridization; D027361:Organic Anion Transporters; D012333:RNA, Messenger / Q000096:biosynthesis; D016335:Zinc Fingers
D017920:Antiporters; D004268:DNA-Binding Proteins; D027361:Organic Anion Transporters; D012333:RNA, Messenger; C503526:SLCO2A1 protein, human; C503528:Slco2a1 protein, rat