title: Protection of mice from fatal bubonic and pneumonic plague by passive immunization with monoclonal antibodies against the F1 protein of Yersinia pestis.
abstract: Monoclonal antibodies (MAbs) to the fraction 1 (F1) protein of Yersinia pestis protected mice against fatal pneumonic as well as bubonic plague from wild-type F1+ organisms. The rare isolation of a virulent F1- isolate from surviving animals supports earlier studies suggesting that improved vaccines should consist of immunogens to protect against F1- variants. The high degree of protection with IgG MAb suggests that secretory IgA is not required for protection from pneumonic plague.
authors.affiliation: U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland 21702-5011, USA.
authors.forename: G W
authors.initials: GW
authors.lastname: Anderson
authors.forename: P L
authors.initials: PL
authors.lastname: Worsham
authors.forename: C R
authors.initials: CR
authors.lastname: Bolt
authors.forename: G P
authors.initials: GP
authors.lastname: Andrews
authors.forename: S L
authors.initials: SL
authors.lastname: Welkos
authors.forename: A M
authors.initials: AM
authors.lastname: Friedlander
authors.forename: J P
authors.initials: JP
authors.lastname: Burans
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000008:administration & dosage / Q000627:therapeutic use*; D000914:Antibodies, Viral / Q000097:blood; D001426:Bacterial Proteins / Q000276:immunology*; D004306:Dose-Response Relationship, Immunologic; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D007116:Immunization, Passive; D007274:Injections, Intraperitoneal; D051379:Mice; D010930:Plague / Q000517:prevention & control*; D015010:Yersinia pestis / Q000276:immunology*
chemical_list: D000911:Antibodies, Monoclonal; D000914:Antibodies, Viral; D001426:Bacterial Proteins