[Effect of furosemide on transperitoneal transport of guanidine derivatives: in vitro studies].
The transperitoneal transport dynamics (removal) of guanidinoacetic acid (GAA) and guanidinosuccinic acid (GSA) has been determined in vitro in the control conditions and after application of furosemide (10(-4) mmol/l) on the mesothelial side of the membrane. GAA peritoneal transfer values, as a rule, were higher than GSA and equaled at mean, in the control series of experiments 0.132 i 0.068 mg x 10(-4) x cm-2 x s-2, respectively. Furosemide decreased GSA passage in 30 min after it addition by about 30%, but GSA transfer diminished later, in 120 min., by about 37%. Therefore, mean GAA transport values before (30-90 min.) and after application of furosemide (120-210 min.) were not statistically significant differentiated, whereas GSA transport parameters were lowered by about 40%. Heterogeneity of the peritoneal GAA and GSA transport dynamics in the control series of the experiments, as well as in the series with furosemide, may be related to the physico-chemical differences (e.g. molecular mass) of the analysed derivates.
Czyzewska
K
K
Katedry i Zakładu Patofizjologii.
Pietrzak
I
I
Antoniewicz
K
K
D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D004848:Epithelium / Q000187:drug effects / Q000378:metabolism; D005665:Furosemide / Q000494:pharmacology*; D006146:Guanidines / Q000378:metabolism*; D066298:In Vitro Techniques; D008970:Molecular Weight; D010537:Peritoneum / Q000187:drug effects / Q000378:metabolism*; D011817:Rabbits
D006146:Guanidines; D005665:Furosemide
Wpływ furosemidu na przezotrzewnowy transport pochodnych guanidynowych: Badania in vitro.