Crotonaldehyde: a carcinogenic and mutagenic air, water and food pollutant.
Crotonaldehyde is mutagenic and carcinogenic and it is ubiquitous in our environment. The data base does, however, not allow an assessment of the carcinogenic risk. We have developed a sensitive 32P-postlabelling technique which allows the detection of specific DNA-adducts in animal tissues as markers for initiation of cancer cells. Adducts were found in several organs of F 344 rats after gavage and persisted to a certain extent. The determination of adduct levels in animal tissues after different exposure or even in human tissues can therefore be considered as an effect monitoring and would certainly improve the risk assessment.
Eder
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Department of Toxicology, University of Würzburg, Germany.
Budiawan
Schuler
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D
D000393:Air Pollutants; D000447:Aldehydes / Q000378:metabolism; D000818:Animals; D014408:Biomarkers, Tumor; D002273:Carcinogens; D018736:DNA Adducts; D004273:DNA, Neoplasm; D004785:Environmental Pollutants; D005502:Food; D009153:Mutagens; D010761:Phosphorus Radioisotopes; D051381:Rats; D011916:Rats, Inbred F344; D018570:Risk Assessment; D014873:Water Pollutants
D000393:Air Pollutants; D000447:Aldehydes; D014408:Biomarkers, Tumor; D002273:Carcinogens; D018736:DNA Adducts; D004273:DNA, Neoplasm; D004785:Environmental Pollutants; D009153:Mutagens; D010761:Phosphorus Radioisotopes; D014873:Water Pollutants; C012796:2-butenal