title: Coagulation activation in extracorporeal hemodialysis.
abstract: The authors evaluated the behavior of protein C activity, factor X and factor VII coagulant activity and serum lipoprotein(a) before and after dialytic treatment in patients on maintenance hemodialysis. They observed depressed protein C activity that significantly (p < 0.005) increased and became normal immediately after hemodialysis while factor X and factor VII increased (p < 0.01; p < 0.05) despite heparinization together with amount of serum lipoprotein(a). In vitro incubation (30' at 37 degrees C) of uremic and healthy blood showed a decrease in serum lipoprotein(a) concentration. After heparin addition (final concentration 0.5 U/ml) lipoprotein(a) increased in the uremic blood only. The clinical and physiopathological implications of these results are discussed.
authors.affiliation: Clinical Medicines Institute I, Pisa University, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Camici
authors.forename: L
authors.initials: L
authors.lastname: Evangelisti
authors.forename: P
authors.initials: P
authors.lastname: Balestri
authors.forename: L
authors.initials: L
authors.lastname: Cioni
authors.forename: P
authors.initials: P
authors.lastname: Rindi
authors.forename: A
authors.initials: A
authors.lastname: Sagripanti
authors.forename: M
authors.initials: M
authors.lastname: Meriggioli
authors.forename: R
authors.initials: R
authors.lastname: Giordani
mesh_terms: D000328:Adult; D000368:Aged; D001777:Blood Coagulation; D001798:Blood Proteins / Q000032:analysis; D005167:Factor VII / Q000032:analysis*; D005170:Factor X / Q000032:analysis*; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000628:therapy; D017270:Lipoprotein(a) / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011486:Protein C / Q000032:analysis*; D006435:Renal Dialysis / Q000592:standards*; D014511:Uremia / Q000097:blood
chemical_list: D001798:Blood Proteins; D017270:Lipoprotein(a); D011486:Protein C; D005167:Factor VII; D005170:Factor X