title: [Hepatic distomatosis of tumor form after prolonged treatment with corticoids].
abstract: A 49-year woman, living in Cameroun and treated by steroids for connective tissue disease, was admitted for a liver mass and epigastric pain. An increase in blood count of eosinophils (1,590.10(9)/L) was observed. Imaging examination showed the presence of a voluminous, multilocular, and heterogeneous hepatic lesion. Pathological examination of the liver showed no evidence of tumor but revealed a rounded cuticle remnant, compatible with bilharziosis eggs or loase transversal section, and Charcot-Leyden's crystals. Due to the uncertainty of diagnosis, a right hepatectomy was performed. Pathological and parasitological examination of the surgical specimen confirmed the diagnosis of hepatic distomatosis, with typical eggs of Fasciola hepatica within necrotic tissue, surrounded by eosinophilic inflammatory infiltrates. Specific serology was positive. The presence of intraparenchymatous eggs was unusual and reflected the ectopic migration of a mature fluke into the hepatic parenchyma, even though the worm was not found in the surgical specimen. Serology for fascioliasis should be performed in any patient suffering from hepatic lesions with eosinophilia.
authors.affiliation: Laboratoire de Parasitologie-Mycologie, Hôpital Cochin, Paris.
authors.forename: M F
authors.initials: MF
authors.lastname: Gavinet
authors.forename: B
authors.initials: B
authors.lastname: Dousset
authors.forename: X
authors.initials: X
authors.lastname: Puechal
authors.forename: A
authors.initials: A
authors.lastname: Louvel
authors.forename: M
authors.initials: M
authors.lastname: Tulliez
authors.forename: C J
authors.initials: CJ
authors.lastname: Menkes
authors.forename: C
authors.initials: C
authors.lastname: Tourte-Schaefer
mesh_terms: D003937:Diagnosis, Differential; D005211:Fascioliasis / Q000175:diagnosis / Q000209:etiology* / Q000469:parasitology; D005260:Female; D005938:Glucocorticoids / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D016867:Immunocompromised Host; D008113:Liver Neoplasms / Q000175:diagnosis* / Q000209:etiology; D008875:Middle Aged; D017285:Polymyositis / Q000188:drug therapy; D011239:Prednisolone / Q000009:adverse effects* / Q000627:therapeutic use; D013997:Time Factors
chemical_list: D005938:Glucocorticoids; D011239:Prednisolone
vernacular_title: Distomatose hépatique à forme tumorale après traitement prolongé par les corticoïdes.