Sjögren's syndrome with acute renal failure caused by renal pseudolymphoma.
A 56-year-old man with Sjögren's syndrome was found to have acute renal failure. Immunopathologic analysis of renal biopsy specimens showed polyclonal lymphocytic interstitial infiltration. DNA analysis of the T-cell receptor and the heavy chain immunoglobulin genes showed a polyclonal pattern of gene rearrangements. Renal failure caused by this pseudolymphoma regressed dramatically with steroid therapy. This is the first reported case of proven renal pseudolymphoma that regressed with steroid therapy.
Cacoub
P
P
Department of Internal Medicine, Hopital de La Pitié-Salpêtrière, Paris, France.
Ginsburg
C
C
Tazi
Z
Z
Beaufils
H
H
Charlotte
F
F
Davi
F
F
Carde
P
P
Godeau
P
P
D058186:Acute Kidney Injury / Q000188:drug therapy / Q000209:etiology*; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007668:Kidney / Q000473:pathology; D007680:Kidney Neoplasms / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D008875:Middle Aged; D011241:Prednisone / Q000627:therapeutic use; D012859:Sjogren's Syndrome / Q000150:complications*
D005938:Glucocorticoids; D011241:Prednisone; D008775:Methylprednisolone