[Overcoming of multidrug resistance and its clinical application].
P-glycoprotein plays a key role in the mechanisms of multidrug resistance in experimental tumors as well as in clinical tumors in acquired-type resistance and in intrinsic-type resistance. Thus the therapeutic approaches targeting the P-glycoprotein would provide benefits in eradication of drug-resistant tumor cells. Practical approaches to overcoming of multidrug resistance by targeting the P-glycoprotein would be; to use agents including calcium channel blocker-related agents and membrane-modifying agents that interact with P-glycoprotein, although some potential problems concerning side effects still remained to be studied.
Tsuruo
T
T
Institute of Molecular and Cellular Biosciences, University of Tokyo.
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000502:physiology; D000970:Antineoplastic Agents / Q000493:pharmacokinetics / Q000627:therapeutic use; D002121:Calcium Channel Blockers / Q000494:pharmacology / Q000627:therapeutic use*; D018432:Drug Resistance, Multiple; D019008:Drug Resistance, Neoplasm; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy*
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D000970:Antineoplastic Agents; D002121:Calcium Channel Blockers