title: A subset of senile dementia with high incidence of the apolipoprotein E epsilon2 allele.
abstract: There is a subset of very elderly patients with senile dementia in whom abundant neurofibrillary tangles are present, mainly in the hippocampal region, without a significant number of senile plaques. In a retrospective neuropathological examination of 239 dementia patients, 14 were found to have this type of senile dementia. The apolipoprotein E epsilon2, epsilon3, and epsilon4 allele frequencies in this patient group were 0.39, 0.50, and 0.11, respectively. Such a high frequency of the epsilon2 allele suggests that this type of dementia is distinct from Alzheimer's disease not only from a neuropathological but also from a genetic viewpoint.
authors.affiliation: Department of Neuropathology, Tokyo Institute of Psychiatry, Setagaya-ku, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Ikeda
authors.forename: H
authors.initials: H
authors.lastname: Akiyama
authors.forename: T
authors.initials: T
authors.lastname: Arai
authors.forename: N
authors.initials: N
authors.lastname: Sahara
authors.forename: H
authors.initials: H
authors.lastname: Mori
authors.forename: M
authors.initials: M
authors.lastname: Usami
authors.forename: M
authors.initials: M
authors.lastname: Sakata
authors.forename: T
authors.initials: T
authors.lastname: Mizutani
authors.forename: K
authors.initials: K
authors.lastname: Wakabayashi
authors.forename: H
authors.initials: H
authors.lastname: Takahashi
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D053329:Apolipoprotein E2; D001057:Apolipoproteins E / Q000235:genetics*; D003704:Dementia / Q000235:genetics* / Q000473:pathology*; D005787:Gene Frequency; D005838:Genotype; D005911:Gliosis; D006624:Hippocampus / Q000473:pathology; D006801:Humans; D016874:Neurofibrillary Tangles / Q000473:pathology*; D012189:Retrospective Studies
chemical_list: D053329:Apolipoprotein E2; D001057:Apolipoproteins E