title: Oocyte quality in polycystic ovaries revisited: identification of a particular subgroup of women.
abstract: OBJECTIVE
  Our purpose was to assess the endocrine status of women with polycystic ovaries (PCO) undergoing IVF, and to compare oocyte quality with endocrine markers of the syndrome, in an attempt to define a subpopulation with poor quality oocytes.
  
  
  METHODS
  This was a retrospective study. Patients were first endocrinologically analyzed: serum levels of androgens (T, androstenedione, DHEAS), FSH, and LH as well as glucose and insulin after an oral glucose tolerance test (OGTT) were recorded and are expressed as absolute values and area under the curve (AUC). Subsequently, they were followed over a 2-year period in which patients underwent several attempts of IVF as well as serving as oocyte donors. Patients were divided into three groups: group I (n = 4) was women who displayed embryos unable to implant in 15 IVF cycles and 10 ovum donation cycles in which they served as donors; group II (n = 16) was PCO patients in whom IVF (n = 38) and/or oocyte donation cycles (n = 42) resulted in pregnancies; and group III (n = 13) was IVF patients with normal appearance of the ovaries by ultrasound. The endocrine status was compared with the IVF results.
  
  
  RESULTS
  There was no difference among groups in the endocrinological parameters tested, except for the OGTT which identified women in group I as having higher serum glucose and insulin levels than patients in groups II and III. Similarly, the OGTT showed higher serum glucose values in group II compared to group III. Women in group I were also obese. Patients in group III were older than PCO patients and needed more gonadotropins to reach an ovarian response which resulted in a reduced number of oocytes retrieved. Fertilization was also impaired in group I, in which no pregnancy was recorded.
  
  
  CONCLUSIONS
  This study shows that there is a particular subgroup of PCO patients with lower fertilization rates and embryos unable to implant. These patients are obese and nonhyperandrogenic and show derangements of insulin secretion.
authors.affiliation: Instituto Valenciano de Infertilidad, Valencia, Spain.
authors.forename: F
authors.initials: F
authors.lastname: Cano
authors.forename: J A
authors.initials: JA
authors.lastname: García-Velasco
authors.forename: A
authors.initials: A
authors.lastname: Millet
authors.forename: J
authors.initials: J
authors.lastname: Remohí
authors.forename: C
authors.initials: C
authors.lastname: Simón
authors.forename: A
authors.initials: A
authors.lastname: Pellicer
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D005260:Female; D005307:Fertilization in Vitro; D006728:Hormones / Q000097:blood*; D006801:Humans; D007247:Infertility, Female; D007328:Insulin / Q000097:blood; D009865:Oocytes; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000503:physiopathology*; D011247:Pregnancy; D012189:Retrospective Studies
chemical_list: D001786:Blood Glucose; D006728:Hormones; D007328:Insulin