title: Reduced toxicity and enhanced antitumor efficacy of betacyclodextrin plumbagin inclusion complex in mice bearing Ehrlich ascites carcinoma.
abstract: Inclusion complex of plumbagin was prepared with betacyclodextrin employing neutralization method. The toxicity of the drug was reduced and the antitumor efficacy was enhanced on complexation with betacyclodextrin.
authors.affiliation: College of Pharmaceutical Sciences, Manipal.
authors.forename: U V
authors.initials: UV
authors.lastname: Singh
authors.forename: N
authors.initials: N
authors.lastname: Udupa
mesh_terms: D000042:Absorption; D000704:Analysis of Variance; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000627:therapeutic use* / Q000633:toxicity; D002273:Carcinogens / Q000378:metabolism* / Q000633:toxicity; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy* / Q000378:metabolism / Q000401:mortality; D003505:Cyclodextrins / Q000378:metabolism* / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D004337:Drug Carriers; D004357:Drug Synergism; D005260:Female; D007928:Lethal Dose 50; D051379:Mice; D008807:Mice, Inbred BALB C; D009285:Naphthoquinones / Q000008:administration & dosage / Q000627:therapeutic use* / Q000633:toxicity; D009368:Neoplasm Transplantation; D047392:beta-Cyclodextrins
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D002273:Carcinogens; D003505:Cyclodextrins; D004337:Drug Carriers; D009285:Naphthoquinones; D047392:beta-Cyclodextrins; C031215:betadex; C014758:plumbagin