Influencing virulence factors of Pseudomonas aeruginosa by commercially manufactured disinfectants.
Some commercially manufactured disinfectants tested (Desur, Dezox, Diesen forte, Lysoformin 3,000, Sokrena, Topax 91) depressed Pseudomonas aeruginosa virulence factors (elastase and proteinase), Nobacel did not. The degree of inhibition was directly proportional to the disinfectant concentration. The most effective concentrations were 1/4 of the MICs. Topax 91 most significantly suppressed proteinase activity (20.3%), Dezox was the most efficient in case of elastase (47.8%).
Hostacká
A
A
Institute of Preventive and Clinical Medicine, Bratislava, Slovak Republic.
D003864:Depression, Chemical; D004202:Disinfectants / Q000494:pharmacology*; D010450:Endopeptidases / Q000096:biosynthesis*; D008826:Microbial Sensitivity Tests; D010196:Pancreatic Elastase / Q000096:biosynthesis*; D011550:Pseudomonas aeruginosa / Q000187:drug effects / Q000201:enzymology*; D013329:Structure-Activity Relationship
D004202:Disinfectants; D010450:Endopeptidases; D010196:Pancreatic Elastase