Inbred mouse strains differ in sensitivity to "popping" behavior elicited by MK-801.
We examined possible genetic contributions to MK-801-elicited "popping" behavior in mice. MK-801-elicited "popping" behavior may represent a preclinical screening paradigm for identifying novel antipsychotic medications. Specifically, we studied the sensitivity of four inbred strains of mice (BALB/c, C57BL/6, AKR, and DBA/2) to MK-801-elicited "popping" behavior and compared their response to the outbred NIH Swiss strain in which the behavior was first characterized. The BALB/c strain was most sensitive to the elicitation of MK-801 induced popping behavior, whereas the other inbred strains were less sensitive than the outbred strain. The identification of strain differences in MK-801-elicited "popping" behavior suggests an important role for genetic factors in the elicitation of MK-801 "popping" behavior in mice.
Deutsch
S I
SI
Department of Veterans Affairs Medical Center, Psychiatry Service, Washington, DC 20422, USA.
Rosse
R B
RB
Paul
S M
SM
Riggs
R L
RL
Mastropaolo
J
J
D000704:Analysis of Variance; D000818:Animals; D002874:Chromosome Mapping; D016291:Dizocilpine Maleate / Q000494:pharmacology*; D004351:Drug Resistance / Q000235:genetics; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009043:Motor Activity / Q000187:drug effects*; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors*; D013045:Species Specificity
D018691:Excitatory Amino Acid Antagonists; D016194:Receptors, N-Methyl-D-Aspartate; D016291:Dizocilpine Maleate