Biology of TGF-beta in knockout and transgenic mouse models.
This paper reviews the basic biology and biochemistry of the TGF-beta isoforms including their unique serine-threonine receptors and signaling intermediates. Dysregulation of TGF-beta expression and/or receptor/signaling function have been implicated in a wide variety of pathologies. We will discuss mechanisms underlying some of these disease processes as gained from study of transgenic mice in which expression of TGF-beta 1 has either been lost by targeted deletion of its gene, is overexpressed in a tissue-specific manner, or blocked by its latency associated peptide.
Böttinger
E P
EP
Laboratory of Chemoprevention, National Cancer Institute, Bethesda, Maryland, USA.
Letterio
J J
JJ
Roberts
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AB
D000418:Albumins / Q000235:genetics; D000818:Animals; D051379:Mice; D018345:Mice, Knockout; D008822:Mice, Transgenic; D018125:Receptors, Transforming Growth Factor beta / Q000502:physiology; D016212:Transforming Growth Factor beta / Q000235:genetics / Q000502:physiology*
D000418:Albumins; D018125:Receptors, Transforming Growth Factor beta; D016212:Transforming Growth Factor beta