title: Tumour necrosis factor enhances the therapeutic effect of mitoxantrone in human ovarian cancer xenograft.
abstract: The combination of Tumour Necrosis Factor (TNF) and mitoxantrone was evaluated for potential chemotherapeutic effect against a human ovarian cancer cell line A2774 hetero-transplanted in female nude mice. Both antitumour efficacy (relative survival and reduction of ascites) and toxicity (weight loss and liver toxicity) of TNF alone, mitoxantrone alone or TNF + mitoxantrone were evaluated. A significant difference (P < 0.002) was observed only among animals bearing tumours treated with mitoxantrone (0.012 mg/Kg) + TNF (5 x 10(5) U/Kg) and controls. No cytotoxic effects were observed for this combination. These observations provide a rationale for further evaluation of TNF + mitoxantrone based regimes for the treatment of recurrent ovarian cancer.
authors.affiliation: Department Experimental Oncology, Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Noviello
authors.forename: G
authors.initials: G
authors.lastname: Cimoli
authors.forename: A
authors.initials: A
authors.lastname: Cosimi
authors.forename: E
authors.initials: E
authors.lastname: Allievi
authors.forename: P
authors.initials: P
authors.lastname: Galletti
authors.forename: S
authors.initials: S
authors.lastname: Parodi
authors.forename: P
authors.initials: P
authors.lastname: Russo
mesh_terms: D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D004357:Drug Synergism; D005260:Female; D006801:Humans; D007928:Lethal Dose 50; D051379:Mice; D008819:Mice, Nude; D008942:Mitoxantrone / Q000627:therapeutic use; D010051:Ovarian Neoplasms / Q000188:drug therapy*; D011994:Recombinant Proteins / Q000627:therapeutic use; D014183:Transplantation, Heterologous; D014407:Tumor Cells, Cultured; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology
chemical_list: D011994:Recombinant Proteins; D014409:Tumor Necrosis Factor-alpha; D008942:Mitoxantrone