Selected temperature correlates with intensity of fever in rats.
Fever is considered due to an elevation of the setpoint of body temperature. The temperature is regulated at a higher level and the higher temperature is established by activation of the heat-seeking thermoeffectors. However, it is surprising that, for this widely accepted hypothesis, there is little experimental evidence of the setpoint shifting to a higher level. The present study shows, for the first time, a significant correlation between the magnitude of the temperature rise in fever and the ambient temperature selected by rats in a thermal gradient.
Briese
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Universidad de los Andes, Mérida, Venezuela. briesee@ing.ula.ve
D000818:Animals; D001833:Body Temperature Regulation / Q000502:physiology*; D004926:Escherichia coli; D005334:Fever / Q000503:physiopathology*; D006706:Homeostasis / Q000502:physiology; D008070:Lipopolysaccharides / Q000008:administration & dosage; D008297:Male; D051381:Rats
D008070:Lipopolysaccharides