Effect of epirubicin on 3H-thymidine labelling index in cultured L-strain cells.
The effect of epirubicin (EPI) on 3H-thymidine labelling index (3H-TdR LI) of L-strain cells in culture was investigated. EPI concentrations of 0.001 microg/ml, 0.01 microg/ml and 0.1 microg/ml were applied to the cells for 4, 8, 16 and 32 hours. Following the treatment with EPI, labelling process in 3H-TdR medium continued for 0, 2, 4, 8, 16, 20, 22, 25 and 30 hours. The results showed that EPI diminished labelling index of L-strain cells depends on time and applied concentrations. When compared to control this decrease was found statistically significant (p<0.001) in each group.
Ozcan
F G
FG
Dept. of Biology, Faculty of Science, University of Istanbul, Turkey.
Topçul
M R
MR
Yilmazer
N
N
Ridvanogullari
M
M
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology*; D001345:Autoradiography; D004247:DNA / Q000096:biosynthesis / Q000187:drug effects*; D015251:Epirubicin / Q000494:pharmacology*; D007739:L Cells / Q000187:drug effects; D051379:Mice; D016196:S Phase / Q000187:drug effects*; D013936:Thymidine / Q000378:metabolism
D000903:Antibiotics, Antineoplastic; D015251:Epirubicin; D004247:DNA; D013936:Thymidine