Octreotide and potassium homeostasis.
Somatostatin infusion causes hyperkalemia in healthy subjects and in some animal models. The purpose of this investigation was to determine what effect octreotide has on potassium homeostasis during serious illness and if there is a dose-response relationship. Sixty-six male Sprague-Dawley rats (185-225 g) were randomized to receive parenteral nutrition (PN) only, PN plus continuous infusion of Escherichia coli lipopolysaccharide (LPS), or PN plus LPS plus octreotide 10, 100, or 1000 micrograms/kg/day for 48 hours. Before randomization all animals received isocaloric, isonitrogenous, isokalemic PN. A 24-hour urine was collected and a blood sample was taken at the end of the study immediately before euthanization. Data were analyzed by ANOVA and Duncan's multiple range test. Nonhemolyzed serum samples from 50 rats were available for study. Serum potassium concentrations were in the normal range for rats and did not differ significantly among the groups: 5.97 +/- 0.86, 5.96 +/- 1.58, 5.78 +/- 1.48, 5.79 +/- 1.67, 5.35 +/- 0.78 mEq/L, respectively. No differences among groups were found for fractional excretion of potassium or serum creatinine concentration. Octreotide administration in escalating dosages does not cause hyperkalemia in endotoxemic rats given intravenous potassium at a constant rate by PN.
Brown
R O
RO
Department of Clinical Pharmacy, University of Tennessee, Memphis 38163, USA.
Dickerson
R N
RN
Mouser
J F
JF
Hak
E B
EB
Methvin
J T
JT
Hak
L J
LJ
D000818:Animals; D019446:Endotoxemia / Q000139:chemically induced / Q000378:metabolism*; D004926:Escherichia coli; D006706:Homeostasis / Q000187:drug effects*; D008070:Lipopolysaccharides / Q000633:toxicity; D008297:Male; D015282:Octreotide / Q000494:pharmacology*; D010288:Parenteral Nutrition; D011188:Potassium / Q000097:blood / Q000378:metabolism* / Q000652:urine; D017419:Potassium, Dietary / Q000008:administration & dosage; D051381:Rats; D017207:Rats, Sprague-Dawley
D008070:Lipopolysaccharides; D017419:Potassium, Dietary; D015282:Octreotide; D011188:Potassium