title: Penetration of varnishes into demineralized root dentine in vitro.
abstract: In this paper the penetration of three different varnishes employed in caries prevention (Duraphat, Fluor Protector and Cervitec) into demineralized dentine is quantified using confocal laser scanning microscopy. The results show that the varnish penetration into lesions about 85 microns in depth if for Cervitec about 35 microns and considerably less for Duraphat and Fluor Protector. The penetration is into the dentinal tubules and is influenced by dentinal tubule direction. The drying procedure--pretreatment of the dentine--influences the penetration, though sizeably only for Cervitec applications. This paper shows that varnish penetration into the tissue and presumably 'sealing' tubules completely or partly is valuable with respect to root caries prevention and hypersensitivity.
authors.affiliation: Materia Technica, University of Groningen, The Netherlands.
authors.forename: J
authors.initials: J
authors.lastname: Arends
authors.forename: H
authors.initials: H
authors.lastname: Duschner
authors.forename: J L
authors.initials: JL
authors.lastname: Ruben
mesh_terms: D000293:Adolescent; D002648:Child; D002710:Chlorhexidine / Q000493:pharmacokinetics*; D003736:Dental Cavity Lining; D003804:Dentin / Q000378:metabolism* / Q000648:ultrastructure; D003806:Dentin Permeability / Q000187:drug effects; D003807:Dentin Sensitivity / Q000378:metabolism / Q000517:prevention & control; D003890:Desiccation; D004338:Drug Combinations; D005453:Fluorescence; D005460:Fluorides, Topical / Q000493:pharmacokinetics*; D006801:Humans; D018613:Microscopy, Confocal; D010150:Paint; D011140:Polyurethanes / Q000493:pharmacokinetics; D017213:Root Caries / Q000378:metabolism / Q000517:prevention & control; D012821:Silanes / Q000493:pharmacokinetics; D012969:Sodium Fluoride / Q000493:pharmacokinetics; D013943:Thymol / Q000493:pharmacokinetics; D017001:Tooth Demineralization / Q000378:metabolism* / Q000473:pathology; D014092:Tooth Root / Q000378:metabolism* / Q000648:ultrastructure
chemical_list: D004338:Drug Combinations; D005460:Fluorides, Topical; D011140:Polyurethanes; D012821:Silanes; C079161:chlorhexidine, thymol drug combination; C023807:sodium fluoride topical preparation; D013943:Thymol; C022599:Fluor Protector; D012969:Sodium Fluoride; D002710:Chlorhexidine