title: The Helicobacter pylori seroprevalence in blood donors related to Lewis (a,b) histo-blood group phenotype.
abstract: OBJECTIVE
  To study a possible association of the Helicobacter pylori seroprevalence with ABO(H) and Lewis (a,b) blood group phenotypes in blood donors.
  
  
  METHODS
  A cross-sectional study of blood donors using ABO(H) and Lewis (a,b) blood group phenotype as predictors.
  
  
  METHODS
  ABO(H) and Lewis (a,b) blood group phenotyping was performed with monoclonal antibody. The H. pylori immunoglobulin G (IgG) antibody relative activity was evaluated by enzyme-linked immunosorbent assay (ELISA) using acid glycine extract from H. pylori.
  
  
  METHODS
  One hundred and fifty-nine randomly selected blood transfusion donors.
  
  
  RESULTS
  The individuals with Lewis (a+b-)/non-secretor phenotype showed a significantly higher proportion of the H. pylori-seronegative subjects and a lower IgG immune response to H. pylori antigens as compared with the individuals of Lewis (a-b+)/secretor phenotype.
  
  
  CONCLUSIONS
  The Lewis (a,b) histo-blood group antigens are implicated in the mechanisms of naturally occurring resistance to H. pylori infection.
authors.affiliation: Institute of Experimental and Clinical Medicine, Tallinn, Estonia.
authors.forename: K
authors.initials: K
authors.lastname: Klaamas
authors.forename: O
authors.initials: O
authors.lastname: Kurtenkov
authors.forename: M
authors.initials: M
authors.lastname: Ellamaa
authors.forename: T
authors.initials: T
authors.lastname: Wadström
mesh_terms: D000017:ABO Blood-Group System / Q000276:immunology*; D000293:Adolescent; D000328:Adult; D000907:Antibodies, Bacterial / Q000032:analysis*; D000911:Antibodies, Monoclonal; D000942:Antigens, Bacterial / Q000276:immunology; D000954:Antigens, Surface / Q000276:immunology; D001782:Blood Donors; D003430:Cross-Sectional Studies; D004797:Enzyme-Linked Immunosorbent Assay; D004957:Estonia / Q000453:epidemiology; D005260:Female; D016481:Helicobacter Infections / Q000097:blood*; D016480:Helicobacter pylori / Q000276:immunology*; D006801:Humans; D016130:Immunophenotyping; D007983:Lewis Blood Group Antigens / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011897:Random Allocation; D012635:Secretory Component / Q000276:immunology
chemical_list: D000017:ABO Blood-Group System; D000907:Antibodies, Bacterial; D000911:Antibodies, Monoclonal; D000942:Antigens, Bacterial; D000954:Antigens, Surface; D007983:Lewis Blood Group Antigens; D012635:Secretory Component