title: 2,4-dichlorophenoxyacetic acid through lactation induces astrogliosis in rat brain.
abstract: Comparison of astroglial immunoreactivity in mesencephalon, cerebellum, and hippocampus of 25-d-old rat pups exposed to 2,4-dichlorophenoxyacetic acid (2,4-D) through the mother's milk was made using a quantitative immunohistochemical analysis. A glial reaction was detected at the level of serotonergic nuclei and extreme astrogliosis in the hippocampus and cerebellum. A quantitative analysis of reactive astrocytes was performed by using GFAP and S-100 protein as specific markers. The study showed a significant increase in their number, size, number of processes, and density of immunostaining in 2,4-D-exposed animals. Exposure to 2,4-dichlorophenoxyacetic acid on the first days of life modifies the astroglial cytoarchitecture in parallel to previously described neuronal changes.
authors.affiliation: Institute for Cell Biology and Neuroscience Prof. Eduardo De Robertis, School of Medicine, University of Buenos Aires, Argentina.
authors.forename: A
authors.initials: A
authors.lastname: Brusco
authors.forename: J P
authors.initials: JP
authors.lastname: Saavedra
authors.forename: G
authors.initials: G
authors.lastname: García
authors.forename: P
authors.initials: P
authors.lastname: Tagliaferro
authors.forename: A M
authors.initials: AM
authors.lastname: Evangelista de Duffard
authors.forename: R
authors.initials: R
authors.lastname: Duffard
mesh_terms: D015084:2,4-Dichlorophenoxyacetic Acid / Q000009:adverse effects*; D000818:Animals; D001921:Brain / Q000033:anatomy & histology / Q000378:metabolism / Q000473:pathology*; D001923:Brain Chemistry; D005260:Female; D005904:Glial Fibrillary Acidic Protein / Q000276:immunology / Q000378:metabolism; D005911:Gliosis / Q000139:chemically induced* / Q000473:pathology; D006540:Herbicides / Q000009:adverse effects*; D007150:Immunohistochemistry; D007774:Lactation / Q000378:metabolism*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013194:Staining and Labeling
chemical_list: D005904:Glial Fibrillary Acidic Protein; D006540:Herbicides; D015084:2,4-Dichlorophenoxyacetic Acid