title: Relationship between isokinetic muscle strength and exercise capacity in chronic heart failure.
abstract: The exercise intolerance and excessive ventilatory response to exercise of chronic heart failure is associated with abnormalities of skeletal muscle function, in particular a reduction in muscle strength. Isometric and isokinetic leg muscle strength were measured in 10 patients with chronic heart failure and 10 age-matched controls. Each subject undertook maximal exercise testing to measure peak oxygen consumption (V(O2)) and the ventilatory response to exercise as measured by the slope of the relation between ventilation and carbon dioxide production (V(E)/V(CO2) slope). Quadriceps strength (mean (S.D.)) was reduced in heart failure as measured by isometric (444.9 (129.6) N vs. 556.0 (136.0); P<0.01) and isokinetic (123.6 (30.2) Nm vs. 146.8 (40.0); P=0.04). Hamstring strength was also reduced as measured by isokinetic testing (53.6 (15.6) Nm vs. 71.1 (28.1); P=0.02). Isokinetic and isometric strengths correlated, but not closely (r=0.52, P<0.001). There were negative correlations between the V(E)/V(CO2) slope, and isokinetic measures: with average torque, r=-0.62, P<0.004; with peak torque, r=-0.64, P=0.002. We have found evidence for reduced muscle function affecting both knee flexors and extensors. This reduction in muscle strength correlates with the ventilatory response to exercise. These observations lend support to the muscle hypothesis of the generation of symptoms in chronic heart failure.
authors.affiliation: Medical Unit C, Southern General Hospital, Glasgow, UK.
authors.forename: A
authors.initials: A
authors.lastname: Clark
authors.forename: D
authors.initials: D
authors.lastname: Rafferty
authors.forename: K
authors.initials: K
authors.lastname: Arbuthnott
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use; D002245:Carbon Dioxide / Q000378:metabolism; D016022:Case-Control Studies; D004232:Diuretics / Q000627:therapeutic use; D017079:Exercise Tolerance; D006333:Heart Failure / Q000188:drug therapy / Q000503:physiopathology*; D006801:Humans; D007537:Isometric Contraction / Q000502:physiology; D007719:Knee Joint / Q000503:physiopathology; D007866:Leg; D008875:Middle Aged; D009119:Muscle Contraction / Q000502:physiology; D018482:Muscle, Skeletal / Q000503:physiopathology*; D010101:Oxygen Consumption / Q000502:physiology; D005082:Physical Exertion / Q000502:physiology; D011659:Pulmonary Gas Exchange; D012119:Respiration / Q000502:physiology; D013710:Tendons / Q000503:physiopathology; D019415:Torque
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D004232:Diuretics; D002245:Carbon Dioxide