title: [Correlation of prostatic specific antigen, tumor grade, and local stage with bone scintigraphy in the staging of patients with prostatic cancer].
abstract: OBJECTIVE
  To determine the capacity of PSA, tumor grade and local stage to predict the bone scintiscan findings in patients with newly diagnosed, untreated prostate cancer.
  
  
  METHODS
  We analyzed the records of 189 patients with prostate cancer that had been seen at our institution from January, 1993 to September, 1995. PSA determination was performed prior to biopsy, local staging by DRE or transrectal US was done and they had a bone scintiscan before treatment.
  
  
  RESULTS
  21% of the patients had metastasis. Univariate analysis showed PSA (p < 0.001), tumor grade (p = 0.01) and local stage (p = 0.001) independently predicted the positive bone scintiscans. However, multivariate regression analysis showed tumor grade (rc = 0.05) or stage (rc = 0.07) did not increase the predictive value of PSA (rc = 0.22). The highest negative predictive value of PSA [95% (IC95 = 87.5%, 98.6%)] was obtained when 20 ng/ml was used as cutoff. Therefore 1.4% to 13.5% of the patients with bone metastasis could not have been diagnosed without scintigraphy.
  
  
  CONCLUSIONS
  Bone scintigraphy should be performed routinely to determine the extent of the lesion in patients with prostatic cancer, particularly in those patients that are likely to undergo radical treatment.
authors.affiliation: Servicio de Urología, Hospital General Universitario Gregorio Marañón, Madrid, España.
authors.forename: F
authors.initials: F
authors.lastname: Herranz Amo
authors.forename: J M
authors.initials: JM
authors.lastname: Díez Cordero
authors.forename: F
authors.initials: F
authors.lastname: Verdú Tartajo
authors.forename: E
authors.initials: E
authors.lastname: Lledó García
authors.forename: C
authors.initials: C
authors.lastname: Subirá Castillón
authors.forename: F
authors.initials: F
authors.lastname: González Chamorro
authors.forename: E
authors.initials: E
authors.lastname: Rodríguez Fernández
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001859:Bone Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D017430:Prostate-Specific Antigen / Q000097:blood; D011471:Prostatic Neoplasms / Q000097:blood / Q000473:pathology*; D011877:Radionuclide Imaging; D012044:Regression Analysis; D012189:Retrospective Studies
chemical_list: D017430:Prostate-Specific Antigen
vernacular_title: Correlación entre el antígeno específico prostático, el grado tumoral y el estadio local con la gammagrafía ósea en el estadadiaje de los pacientes con cáncer de próstata.