Absence of human herpesvirus 8 genomes in coronary atherosclerosis in immunocompetent patients.
Human herpevirus 8 (HHV8) has been localized to the endothelial and spindle cells of KS, suggesting a role for HHV8 in atherosclerosis. None of the 38 coronary atherectomy specimens contained HHV8 with both sensitive nested PCR assays, making it unlikely that persistent viral infection with HHV8 plays a role in coronary atherogenesis in the general population of the United States.
Ye
D
D
Department of Medicine, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, USA.
Nichols
T C
TC
Dehmer
G J
GJ
Tate
D A
DA
Wehbie
R S
RS
Quinlivan
E B
EB
D001483:Base Sequence; D003001:Cloning, Molecular; D003324:Coronary Artery Disease / Q000276:immunology / Q000821:virology*; D004279:DNA, Viral / Q000032:analysis; D019288:Herpesvirus 8, Human / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D012680:Sensitivity and Specificity
D004279:DNA, Viral