Variation in placental type 2 11beta-hydroxysteroid dehydrogenase activity is not related to birth weight or placental weight.
It has been suggested that the association between the development of hypertension and a combination of low birth weight and high placental weight can be explained by variations in expression of NAD+-dependent 11beta-hydroxysteroid dehydrogenase (11-HSD2 or 11-HSD K) in the placenta. Enzymatic activity and mRNA levels of 11-HSD2 were measured in 111 human placentas taken from normal births. There were no correlations between either 11-HSD2 activity or mRNA levels and either fetal or placental weight. These studies suggest that variations in placental 11-HSD activity do not influence fetal or placental weight in humans.
Rogerson
F M
FM
Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas 75235-9063, USA.
Kayes
K M
KM
White
P C
PC
D042842:11-beta-Hydroxysteroid Dehydrogenases; D000293:Adolescent; D000328:Adult; D001724:Birth Weight; D002822:Choriocarcinoma; D003348:Cortisone / Q000378:metabolism; D005260:Female; D006801:Humans; D006913:Hydroxysteroid Dehydrogenases / Q000096:biosynthesis / Q000378:metabolism*; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007527:Isoenzymes / Q000096:biosynthesis / Q000378:metabolism*; D009929:Organ Size; D010920:Placenta / Q000033:anatomy & histology* / Q000201:enzymology*; D011247:Pregnancy; D012333:RNA, Messenger / Q000378:metabolism; D011994:Recombinant Proteins / Q000096:biosynthesis / Q000378:metabolism; D012016:Reference Values; D012307:Risk Factors; D014162:Transfection; D014407:Tumor Cells, Cultured; D014594:Uterine Neoplasms
D007527:Isoenzymes; D012333:RNA, Messenger; D011994:Recombinant Proteins; D006913:Hydroxysteroid Dehydrogenases; D042842:11-beta-Hydroxysteroid Dehydrogenases; D003348:Cortisone