title: A complex containing N-CoR, mSin3 and histone deacetylase mediates transcriptional repression.
abstract: Transcriptional repression by nuclear receptors has been correlated to binding of the putative co-repressor, N-CoR. A complex has been identified that contains N-CoR, the Mad presumptive co-repressor mSin3, and the histone deacetylase mRPD3, and which is required for both nuclear receptor- and Mad-dependent repression, but not for repression by transcription factors of the ets-domain family. These data predict that the ligand-induced switch of heterodimeric nuclear receptors from repressor to activator functions involves the exchange of complexes containing histone deacetylases with those that have histone acetylase activity.
authors.affiliation: Howard Hughes Medical Institute, Department and School of Medicine, University of California, San Diego, La Jolla 92093-0648, USA.
authors.forename: T
authors.initials: T
authors.lastname: Heinzel
authors.forename: R M
authors.initials: RM
authors.lastname: Lavinsky
authors.forename: T M
authors.initials: TM
authors.lastname: Mullen
authors.forename: M
authors.initials: M
authors.lastname: Söderstrom
authors.forename: C D
authors.initials: CD
authors.lastname: Laherty
authors.forename: J
authors.initials: J
authors.lastname: Torchia
authors.forename: W M
authors.initials: WM
authors.lastname: Yang
authors.forename: G
authors.initials: G
authors.lastname: Brard
authors.forename: S D
authors.initials: SD
authors.lastname: Ngo
authors.forename: J R
authors.initials: JR
authors.lastname: Davie
authors.forename: E
authors.initials: E
authors.lastname: Seto
authors.forename: R N
authors.initials: RN
authors.lastname: Eisenman
authors.forename: D W
authors.initials: DW
authors.lastname: Rose
authors.forename: C K
authors.initials: CK
authors.lastname: Glass
authors.forename: M G
authors.initials: MG
authors.lastname: Rosenfeld
mesh_terms: D000818:Animals; D051778:Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; D001665:Binding Sites; D002460:Cell Line; D004268:DNA-Binding Proteins / Q000502:physiology; D005786:Gene Expression Regulation; D006367:HeLa Cells; D006655:Histone Deacetylases / Q000502:physiology*; D006801:Humans; D009687:Nuclear Proteins / Q000502:physiology*; D056971:Nuclear Receptor Co-Repressor 1; D011485:Protein Binding; D051381:Rats; D018160:Receptors, Cytoplasmic and Nuclear / Q000502:physiology; D011988:Receptors, Thyroid Hormone / Q000235:genetics; D011993:Recombinant Fusion Proteins / Q000235:genetics / Q000378:metabolism; D012097:Repressor Proteins / Q000502:physiology*; D029701:Saccharomyces cerevisiae Proteins; D014157:Transcription Factors / Q000502:physiology*; D014158:Transcription, Genetic; D014162:Transfection
chemical_list: D051778:Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; D004268:DNA-Binding Proteins; C079439:MXD1 protein, human; C539127:NCOR1 protein, human; C539129:Ncor1 protein, rat; D009687:Nuclear Proteins; D056971:Nuclear Receptor Co-Repressor 1; D018160:Receptors, Cytoplasmic and Nuclear; D011988:Receptors, Thyroid Hormone; D011993:Recombinant Fusion Proteins; D012097:Repressor Proteins; C071731:SIN3 protein, S cerevisiae; D029701:Saccharomyces cerevisiae Proteins; D014157:Transcription Factors; D006655:Histone Deacetylases