Infantile hypophosphatasia: treatment options to control hypercalcemia, hypercalciuria, and chronic bone demineralization.
A 2-month-old child with infantile hypophosphatasia had hypercalcemia (3.49 mmol/L (14 mg/dl)), nephrocalcinosis, and diminished bone mineral content. Hypercalcemia was corrected with calcitonin. Hypercalciuria and bone demineralization abated with chlorothiazide. Hypercalcemia is hypothesized to be related to normal bone resorption in conjunction with impaired bone mineralization. Chlorothiazide may alleviate this impairment.
Barcia
J P
JP
Department of Pediatrics, Children's Hospital Medical Center, Cincinnati, Ohio.
Strife
C F
CF
Langman
C B
CB
D001862:Bone Resorption / Q000188:drug therapy*; D002116:Calcitonin / Q000627:therapeutic use*; D002118:Calcium / Q000652:urine; D002740:Chlorothiazide / Q000627:therapeutic use*; D004232:Diuretics; D005260:Female; D006801:Humans; D006934:Hypercalcemia / Q000517:prevention & control; D007014:Hypophosphatasia / Q000150:complications / Q000188:drug therapy* / Q000378:metabolism; D007223:Infant; D009397:Nephrocalcinosis / Q000150:complications / Q000188:drug therapy / Q000378:metabolism; D049993:Sodium Chloride Symporter Inhibitors / Q000627:therapeutic use*
D004232:Diuretics; D049993:Sodium Chloride Symporter Inhibitors; D002740:Chlorothiazide; D002116:Calcitonin; D002118:Calcium