title: [Cellular oncogenes and antioncogenes in thyroid tumors].
abstract: Analysis of literature indicates that genetic mechanisms of thyroid tumor development are connected with two main classes of genes: oncogenes whose activation may stimulate tumor growth and anti-oncogenes which acquire oncogenic properties due to the loss of their function through point mutation or deletion. Protooncogene Ras mutation plays a role in the early events in tumor development. Restructuration of Ret and Trk oncogenes, overexpression of Met and Ras point mutations are characteristic for papillary thyroid carcinoma.
authors.forename: A Iu
authors.initials: AIu
authors.lastname: Abrosimov
mesh_terms: D003937:Diagnosis, Differential; D016147:Genes, Tumor Suppressor; D011905:Genes, ras; D006801:Humans; D011379:Prognosis; D011519:Proto-Oncogenes; D013964:Thyroid Neoplasms / Q000175:diagnosis / Q000235:genetics*
vernacular_title: Kletochnye onkogeny i antionkogeny v opukholiakh shchitovidnoĭ zhelezy.