Proteinuria and progression of renal disease: therapeutic implications.
The relationship between proteinuria and progression of renal disease has long been an issue of debate. The present review deals with some of the recent publications on this topic. New concepts are emphasized: the possible causal role of proteinuria in the pathophysiology of progressive renal function loss, and the decrease in urinary protein loss at the beginning of renoprotective therapy as a predictor of renal function outcome during this treatment.
Gansevoort
R T
RT
Department of Medicine, State University Hospital Groningen, The Netherlands.
Navis
G J
GJ
Wapstra
F H
FH
de Jong
P E
PE
de Zeeuw
D
D
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use; D000818:Animals; D003928:Diabetic Nephropathies / Q000503:physiopathology / Q000517:prevention & control*; D018450:Disease Progression; D004232:Diuretics / Q000627:therapeutic use; D005919:Glomerular Filtration Rate; D006801:Humans; D007668:Kidney / Q000503:physiopathology*; D007674:Kidney Diseases / Q000503:physiopathology / Q000517:prevention & control*; D011237:Predictive Value of Tests; D011507:Proteinuria / Q000178:diet therapy / Q000188:drug therapy
D000806:Angiotensin-Converting Enzyme Inhibitors; D004232:Diuretics