title: Initiation and processing of signals from the B cell antigen receptor.
abstract: Current models of signal transduction from the antigen receptors on B and T cells still resemble equations with several unknown elements. Data from recent knockout experiments in cell lines and mice contradict the assumption that Src-family kinase and tyrosine kinases of the Syk/Zap-70 family are the transducer elements that set signaling from these receptors in motion. Using a functional definition of signaling elements, we discuss the current knowledge of signaling events from the BCR and suggest the existence of an as-yet-unknown BCR transducer complex.
authors.affiliation: Department of Molecular Immunology, Biology III, University Freiburg, Germany. reth@immunbio.mpg.de
authors.forename: M
authors.initials: M
authors.lastname: Reth
authors.forename: J
authors.initials: J
authors.lastname: Wienands
mesh_terms: D000818:Animals; D005075:Biological Evolution; D006801:Humans; D051379:Mice; D008954:Models, Biological; D017027:Protein Tyrosine Phosphatases / Q000378:metabolism; D011505:Protein-Tyrosine Kinases / Q000378:metabolism; D011947:Receptors, Antigen, B-Cell / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D011947:Receptors, Antigen, B-Cell; D011505:Protein-Tyrosine Kinases; D017027:Protein Tyrosine Phosphatases