Ploidy profile of morphologically normal squamous epithelium adjacent to high grade cervical intraepithelial neoplasia.
We have investigated the ploidy profile of morphologically normal mucosa adjacent to high grade CIN (n = 16) and also from normal cervix (n = 18). DNA ploidy was assessed using flow cytometry and image analysis. All cases were diploid by both modalities. Our results show that morphologically normal squamous mucosa has a stable ploidy profile even when it lies adjacent to high grade CIN. This finding supports the view that high grade CIN is a neoplastic expansion of transformed cells rather than the result of a field change effect.
McDermott
N
N
Royal College of Surgeons in Ireland, Dublin, Republic of Ireland.
Suliman
Y
Y
Walsh
C B
CB
Kay
E W
EW
Curran
B
B
Milburn
C
C
Turner
M
M
Prendiville
W
W
Leader
M
M
D004848:Epithelium / Q000473:pathology; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D011003:Ploidies; D002583:Uterine Cervical Neoplasms / Q000235:genetics* / Q000473:pathology; D002578:Uterine Cervical Dysplasia / Q000235:genetics* / Q000473:pathology