title: Primary structure of the propeptide and factor VIII-binding domain of bovine von Willebrand factor.
abstract: A 2811 base-pair cDNA, encoding the amino-terminal part of the bovine pre-pro-von Willebrand factor, was characterized and sequenced. The deduced amino acid sequence shares significant homology with the human von Willebrand antigen II and the amino-terminal part of the factor VIII-binding domain of von Willebrand factor. In contrast to human, there is no RGD motif in the bovine von Willebrand antigen II. High levels of Cys, characteristic of D domains, are also found in bovine and the Cys position is markedly conserved between the two species.
authors.affiliation: Unité de Recherches sur l'Hémostase et la Thrombose, INSERM U 143, Hôpital de Bicêtre, France.
authors.forename: N
authors.initials: N
authors.lastname: Janel
authors.forename: A S
authors.initials: AS
authors.lastname: Ribba
authors.forename: G
authors.initials: G
authors.lastname: Chérel
authors.forename: D
authors.initials: D
authors.lastname: Kerbiriou-Nabias
authors.forename: D
authors.initials: D
authors.lastname: Meyer
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002417:Cattle; D018076:DNA, Complementary / Q000737:chemistry; D006801:Humans; D008969:Molecular Sequence Data; D011498:Protein Precursors / Q000737:chemistry*; D017386:Sequence Homology, Amino Acid; D014841:von Willebrand Factor / Q000737:chemistry* / Q000235:genetics
chemical_list: D018076:DNA, Complementary; D011498:Protein Precursors; D014841:von Willebrand Factor