Acute pancreatitis in childhood: research of pathogenesis and clinical implications.
Acute pancreatitis in children is more common than has previously been considered. A recent literature analysis has demonstrated significant resulting morbidity and mortality. Clinical awareness has improved dramatically, as demonstrated by the increase in the number of recent publications and etiological considerations. This review describes novel considerations in research related to the pathogenesis of acute pancreatitis and the arising clinical implications. This relationship is discussed regarding a better understanding of pathogenesis in pediatric disorders; increasing awareness; preventing damage by drugs and toxins; using novel diagnostic markers; and introducing new therapeutic tools.
Weizman
Z
Z
Pediatric Gastroenterology and Nutrition Unit, Soroka Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel. wzvi@bgumail.bgu.ac.il
D000208:Acute Disease; D000818:Animals; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D015994:Incidence; D007557:Israel; D008297:Male; D010195:Pancreatitis / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology* / Q000628:therapy; D011322:Primary Prevention / Q000379:methods; D051381:Rats; D012106:Research; D012189:Retrospective Studies; D012307:Risk Factors; D015996:Survival Rate