title: Modulation of cell proliferation by the integrin cytoplasmic domain.
abstract: Integrin adhesion receptors modulate cell functions, including cell proliferation and survival. The beta 1C integrin, an alternatively spliced form of beta 1A, containing a unique cytoplasmic domain sequence, inhibits cell growth in vitro. In vivo, the expression of beta 1C correlates with a benign, nonproliferative phenotype in epithelial cells. The studies discussed in this article indicate that modulation of cell proliferation, in normal or pathological conditions, might be achieved by the regulated expression of variant integrin subunits.
authors.affiliation: Department of Pathology, Yale University School of Medicine, New Haven, Connecticut, USA.
authors.forename: D Q
authors.initials: DQ
authors.lastname: Zheng
authors.forename: M
authors.initials: M
authors.lastname: Fornaro
authors.forename: C J
authors.initials: CJ
authors.lastname: Bofetiado
authors.forename: G
authors.initials: G
authors.lastname: Tallini
authors.forename: S
authors.initials: S
authors.lastname: Bosari
authors.forename: L R
authors.initials: LR
authors.lastname: Languino
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002455:Cell Division; D002470:Cell Survival; D003593:Cytoplasm / Q000502:physiology; D006801:Humans; D016023:Integrins / Q000737:chemistry / Q000502:physiology*; D008969:Molecular Sequence Data
chemical_list: D016023:Integrins