title: Signet-ring cell oligodendroglioma--report of two cases and discussion of the differential diagnosis.
abstract: Two cases of oligodendroglioma consisting largely of signet-ring cells were analyzed histopathologically, immunohistochemically and at the ultrastructural level. The signet-ring cells were negative for a panel of tumor lineage markers including glial fibrillary acidic protein, and were negative for Ki-67 (MIB-1 immunohistochemistry). In contrast with the abundance of lysosomal structures reportedly present in the so-called eosinophilic granular cells in oligodendrogliomas, degenerating mitochondria were mainly seen in the cytoplasm of the signet-ring cells. The differential diagnosis of the oligodendroglial signet-ring cell tumors occurring in children and in adults is discussed.
authors.affiliation: Department of Pathology/Neuropathology Laboratory, University Hospital Rotterdam-Dijkzigt, The Netherlands.
authors.forename: J M
authors.initials: JM
authors.lastname: Kros
authors.forename: W A
authors.initials: WA
authors.lastname: van den Brink
authors.forename: J J
authors.initials: JJ
authors.lastname: van Loon-van Luyt
authors.forename: S Z
authors.initials: SZ
authors.lastname: Stefanko
mesh_terms: D000293:Adolescent; D001932:Brain Neoplasms / Q000473:pathology* / Q000532:radiotherapy / Q000648:ultrastructure; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D008875:Middle Aged; D008928:Mitochondria / Q000648:ultrastructure; D009410:Nerve Degeneration; D009837:Oligodendroglioma / Q000473:pathology* / Q000532:radiotherapy / Q000648:ultrastructure; D014617:Vacuoles / Q000648:ultrastructure