[The development of a latex antigenic diagnostic agent for the serological determination of tuberculous infection].
Using two tuberculoproteins, phosphatide and polysaccharide antigens obtained from culture filtrate of pathogenic and vaccinal strains of Mycobacterium of human and bull types and standard monodispersed particles of latex modified by different chemical groups, the technology of creation of latex antigenic preparations for serologic express diagnosis of tuberculosis was elaborated. This method is based on the reaction of latex agglutination. Latex diagnostic preparation possesses sufficiently high serologic activity and specificity. The spectrum of microbacterial antigens allows one to characterize the status of immunity of patients with different forms of tuberculosis and to determine the degree of the process activity.
Lonych
L I
LI
Kysel'ov
Ie M
IeM
D000818:Animals; D000941:Antigens / Q000302:isolation & purification; D000942:Antigens, Bacterial / Q000276:immunology; D006801:Humans; D007114:Immunization / Q000379:methods; D007840:Latex / Q000276:immunology*; D007841:Latex Fixation Tests / Q000379:methods*; D009163:Mycobacterium bovis / Q000276:immunology; D009169:Mycobacterium tuberculosis / Q000276:immunology; D011817:Rabbits; D014376:Tuberculosis / Q000175:diagnosis*
D000941:Antigens; D000942:Antigens, Bacterial; D007840:Latex