Apoptosis in cancer.
Apoptosis is a genetically encoded cell death program and plays an important role in the regulation of both normal and malignant processes. Recently, many factors involved in the control of apoptosis have been isolated and characterized, and thereby studies on the molecular mechanism of the signaling pathway of apoptosis have made rapid progress. In this article, we discuss the role of apoptosis in carcinogenesis and the possible ways to apply apoptosis to cancer therapy.
Kuchino
Y
Y
Biophysics Division National Cancer Center Research Institute, Tokyo, Japan.
Kitanaka
C
C
D017209:Apoptosis / Q000502:physiology*; D016158:Genes, p53 / Q000502:physiology; D015316:Genetic Therapy; D006801:Humans; D009369:Neoplasms / Q000235:genetics* / Q000628:therapy