title: Effect of exogenous cholecystokinin on the discharge of the gallbladder and the secretion of trypsin and chymotrypsin from the pancreas of the Atlantic salmon, Salmo salar L.
abstract: The humoral control of release of the proteases trypsin and chymotrypsin was investigated in the Atlantic salmon (Salmo salar L.). Intraperitoneal injection of a purified preparation of the peptide cholecystokinin (CCK) from pig into starved fish produces a dose-dependent release of both enzymes from the pyloric caeca/pancreas tissues which accumulate in the intestinal contents (digesta). It also induces release of the contents of the gallbladder. Isolated preparations of pyloric caeca/pancreas when incubated with CCK release trypsin and chymotrypsin. It is concluded that while a possible role for a neuronal component to the control and regulation of these enzymes cannot be ruled out, humoral control by a CCK-like peptide has been established. The fact that a mammalian-derived extract of CCK induces this response in fish indicates an early evolution and subsequent conservation of this control mechanism in the vertebrates.
authors.affiliation: Department of Zoophysiology, Zoological Institute, Göteborgs University, Sweden.
authors.forename: S
authors.initials: S
authors.lastname: Einarsson
authors.forename: P S
authors.initials: PS
authors.lastname: Davies
authors.forename: C
authors.initials: C
authors.lastname: Talbot
mesh_terms: D000818:Animals; D002766:Cholecystokinin / Q000008:administration & dosage / Q000494:pharmacology*; D002918:Chymotrypsin / Q000187:drug effects / Q000378:metabolism*; D005704:Gallbladder / Q000187:drug effects* / Q000378:metabolism; D066298:In Vitro Techniques; D010179:Pancreas / Q000187:drug effects / Q000378:metabolism*; D012474:Salmon / Q000033:anatomy & histology* / Q000378:metabolism*; D014357:Trypsin / Q000187:drug effects / Q000378:metabolism*
chemical_list: D002766:Cholecystokinin; D002918:Chymotrypsin; D014357:Trypsin