title: A comparison of semantic memory in vascular dementia and dementia of Alzheimer's type.
abstract: OBJECTIVE
  To determine whether semantic memory is impaired in vascular dementia and to assess the utility of semantic memory measures in differentiating vascular dementia from dementia of Alzheimer's type (DAT).
  
  
  METHODS
  Case-control study.
  
  
  METHODS
  Ten patients with Cambridge Mental Disorders in the Elderly (CAMDEX) diagnosis of 'definite' mild or moderate vascular dementia (mean age 77) were individually matched with 10 patients with a CAMDEX diagnosis of 'definite' DAT on the basis of age, education, sex, premorbid IQ (as measured by the National Adult Reading Test) and performance on the Cambridge Cognitive Examination (CAMCOG). In addition, 10 age, sex and education matched volunteer or relative controls were assessed.
  
  
  METHODS
  A detailed semantic memory test battery consisting of five subtests: category fluency, picture naming, picture sorting, word-picture matching and generation of verbal definitions.
  
  
  RESULTS
  Compared to normal controls, both patient groups were impaired on all subtests of the semantic battery with the exception of the word-picture matching test. No differences were found between the vascular dementia and DAT groups on any of the measures.
  
  
  CONCLUSIONS
  Impairment of semantic memory is a feature of both vascular dementia and DAT. Tests of semantic memory appear, therefore, of little value in differentiating between these two major causes of dementia. Further work is required to determine whether the nature of the processing deficit is the same in these conditions.
authors.affiliation: Queen Elizabeth Hospital, Edgbaston, Birmingham, UK.
authors.forename: P W
authors.initials: PW
authors.lastname: Bentham
authors.forename: S
authors.initials: S
authors.lastname: Jones
authors.forename: J R
authors.initials: JR
authors.lastname: Hodges
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000145:classification* / Q000175:diagnosis / Q000523:psychology; D016022:Case-Control Studies; D015140:Dementia, Vascular / Q000145:classification* / Q000175:diagnosis / Q000523:psychology; D005260:Female; D006801:Humans; D007802:Language; D008297:Male; D008568:Memory; D011594:Psychometrics / Q000379:methods