Calretinin in the mouse superior colliculus originates from retinal ganglion cells.
We investigated the origin of the calretinin-immunoreactive fibers in the mouse superior colliculus. The dense plexus of calretinin-positive fibers in the superficial layers of the colliculus was completely eliminated after eye enucleation. Retrograde tracing combined with immunohistochemistry revealed many calretinin-positive small-to-medium retinal ganglion cells projecting to the colliculus. These results indicate that calretinin-containing ganglion cells are the source of this calcium-binding protein in the superficial layers of the superior colliculus.
Gobersztejn
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Departamento de Fisiologia e Biofísica, Universidade de São Paulo, Brasil. fernanda@bmb.icb1.usp.br
Britto
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LR
D000818:Animals; D064032:Calbindin 2; D005136:Eye Proteins / Q000378:metabolism*; D051379:Mice; D012162:Retinal Degeneration / Q000378:metabolism; D012165:Retinal Ganglion Cells / Q000378:metabolism*; D064030:S100 Calcium Binding Protein G / Q000378:metabolism*; D013477:Superior Colliculi / Q000033:anatomy & histology* / Q000378:metabolism*
C576511:Calb2 protein, mouse; D064032:Calbindin 2; D005136:Eye Proteins; D064030:S100 Calcium Binding Protein G