Detection of rhinovirus in sinus brushings of patients with acute community-acquired sinusitis by reverse transcription-PCR.
Of 20 adults with acute community-acquired sinusitis (ACAS), rhinovirus was detected in specimens from 10 (50%) patients, including maxillary aspirates from 8 (40%) patients and nasal swabs from 9 (45%) patients, by reverse transcription-PCR (RT-PCR). Human coronavirus was detected by RT-PCR in nasal swabs from 3 of 20 patients but in no sinus secretions. These findings suggest that rhinovirus is an important cause of ACAS and that viral invasion of the sinus cavity itself may be a common event during the disease.
Pitkäranta
A
A
Department of Internal Medicine, University of Virginia, Charlottesville 22908, USA.
Arruda
E
E
Malmberg
H
H
Hayden
F G
FG
D000328:Adult; D000368:Aged; D017714:Community-Acquired Infections / Q000821:virology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010850:Picornaviridae Infections / Q000821:virology*; D016133:Polymerase Chain Reaction / Q000379:methods; D012229:Rhinovirus / Q000302:isolation & purification*; D012852:Sinusitis / Q000821:virology*