title: Non-organ specific autoantibodies against cellular components in HIV-1 infected individuals.
abstract: OBJECTIVE
  To detect the presence of autoantibodies against cellular components in HIV-1 infected individuals.
  
  
  METHODS
  Serum samples from 87 patients with HIV-1 infection and from 17 healthy HIV-seronegative controls were tested using sensitive and specific techniques (immunoblot, RNA precipitation), as well as counterimmunoelectrophoresis and indirect immunofluorescence.
  
  
  RESULTS
  Four sera (4.6%) showed reactivity in immunoblot against various unidentified cytoplasmic autoantigens. The four positive sera were obtained from patients belonging in equal numbers to the non-AIDS and AIDS groups.
  
  
  CONCLUSIONS
  It appears that the production of antibodies against cellular components rarely occurs during the clinical course of HIV infection.
authors.affiliation: Department of Pathophysiology, Medical School of Athens, Greece.
authors.forename: T
authors.initials: T
authors.lastname: Kordossis
authors.forename: L
authors.initials: L
authors.lastname: Piha
authors.forename: A
authors.initials: A
authors.lastname: Guialis
authors.forename: O
authors.initials: O
authors.lastname: Kosmopoulou
authors.forename: A G
authors.initials: AG
authors.lastname: Tzioufas
authors.forename: H M
authors.initials: HM
authors.lastname: Moutsopoulos
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000097:blood / Q000145:classification / Q000276:immunology; D000328:Adult; D000918:Antibody Specificity; D001323:Autoantibodies / Q000276:immunology*; D001324:Autoantigens / Q000097:blood / Q000276:immunology; D015153:Blotting, Western; D003378:Counterimmunoelectrophoresis; D003593:Cytoplasm / Q000276:immunology / Q000821:virology; D005260:Female; D019085:Fluorescent Antibody Technique, Direct; D015658:HIV Infections / Q000276:immunology* / Q000473:pathology; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011233:Precipitin Tests; D011506:Proteins / Q000276:immunology / Q000378:metabolism; D012313:RNA / Q000097:blood / Q000276:immunology; D013194:Staining and Labeling
chemical_list: D001323:Autoantibodies; D001324:Autoantigens; D011506:Proteins; D012313:RNA