title: Clinical feasibility of echocardiographic automated border detection in monitoring left ventricular response to acute changes of preload in normal subjects.
abstract: Echocardiographic automated border detection (ABD) provides an instantaneous measurement of left ventricular (LV) volume and its rate of change. We tested the clinical feasibility of ABD in monitoring on-line LV response to acute changes in preload. We examined 20 healthy males in the supine position, with legs elevated, back in the supine position, 5 min after the inflation of blood pressure cuffs at the root of the four limbs, 5 min after the deflation of cuffs. End-diastolic and end-systolic LV volumes significantly increased with elevated legs and decreased during cuff inflation; ejection fraction remained unchanged. Peak filling and peak emptying rates did not change with elevated legs and increased significantly during cuff inflation. The values of LV parameters were stable in the three resting conditions, demonstrating a good reproducibility of the ABD technique. Our results demonstrate that ABD may be useful in clinical practice for monitoring on-line small acute changes in LV volume and function.
authors.affiliation: Department of Clinical and Biological Sciences, University of Pavia, Second Faculty of Medicine, Varese, Italy.
authors.forename: A M
authors.initials: AM
authors.lastname: Grandi
authors.forename: M
authors.initials: M
authors.lastname: Bignotti
authors.forename: A
authors.initials: A
authors.lastname: Bertolini
authors.forename: G
authors.initials: G
authors.lastname: Gaudio
authors.forename: P
authors.initials: P
authors.lastname: Zanzi
authors.forename: L
authors.initials: L
authors.lastname: Guasti
authors.forename: B
authors.initials: B
authors.lastname: Nardo
authors.forename: A
authors.initials: A
authors.lastname: Venco
mesh_terms: D000328:Adult; D001331:Automation; D001794:Blood Pressure; D004452:Echocardiography / Q000379:methods*; D006339:Heart Rate; D006352:Heart Ventricles / Q000000981:diagnostic imaging; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D012016:Reference Values; D015203:Reproducibility of Results; D013318:Stroke Volume; D016683:Supine Position; D016276:Ventricular Function; D016277:Ventricular Function, Left / Q000502:physiology*