Getting it together: signal transduction in G-protein coupled receptors by association of receptor domains.
The mechanism of signal transduction by G-protein coupled receptors is unknown. Here, we propose that these receptors signal in a way that is qualitatively similar to that seen in the chemokine and endocrine hormone receptor families; the signal occurs when two domains of the receptor are brought together, although this is not the only requirement for signaling.
Underwood
D J
DJ
Merck Research Laboratories, West Point, PA 19486, USA. dju@merck.com
Prendergast
K
K
D000818:Animals; D001665:Binding Sites; D019204:GTP-Binding Proteins / Q000378:metabolism*; D006801:Humans; D008024:Ligands; D008565:Membrane Proteins / Q000737:chemistry / Q000378:metabolism; D008958:Models, Molecular; D017433:Protein Structure, Secondary; D018343:Receptors, Adrenergic, beta-2 / Q000737:chemistry; D011956:Receptors, Cell Surface / Q000737:chemistry / Q000378:metabolism*; D018047:Receptors, Purinergic P1 / Q000737:chemistry; D015398:Signal Transduction / Q000502:physiology*; D013816:Thermodynamics
D008024:Ligands; D008565:Membrane Proteins; D018343:Receptors, Adrenergic, beta-2; D011956:Receptors, Cell Surface; D018047:Receptors, Purinergic P1; D019204:GTP-Binding Proteins