title: [The mutation units of loci coding for lactate dehydrogenase and their directed changes in the phylogenetic progression of vertebrate animals].
abstract: Comparison of the electrophoretic mobility of various alleles of Ldh-A and B loci within and between species demonstrated a decreased range of variation from fish to anuran amphibians and from anurans to mammals. Fish and mammals feature incompatible ranges of this variation, usually having a mobility range above and below the first zone of Ldh-A and B loci heterodimers, respectively. Amphibians feature both types of variation. Such a quality difference in allelic variation may result from scaling down the amino acid changes from mutation of intragenic regions in fish to single amino acid substitutions in mammals.
authors.forename: S V
authors.initials: SV
authors.lastname: Mezhzherin
mesh_terms: D000483:Alleles; D000596:Amino Acids / Q000235:genetics; D000818:Animals; D004586:Electrophoresis; D005815:Genetic Code / Q000235:genetics*; D014644:Genetic Variation / Q000235:genetics; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000235:genetics*; D009154:Mutation / Q000235:genetics*; D010802:Phylogeny; D013045:Species Specificity; D014714:Vertebrates / Q000235:genetics*
chemical_list: D000596:Amino Acids; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase