title: Changes in leg vein filling and emptying characteristics and leg volumes during long-term head-down bed rest.
abstract: Leg venous hemodynamics [venous distensibility index (VDI), arterial flow index (AFI), half-emptying time (T1/2)], and leg volumes (LV) were assessed by mercury strain-gauge plethysmography with venous occlusion and volometry, respectively, in seven men before, during, and after 42 days of 6 degrees head-down bed rest. Results showed a high increase in VDI up to day 26 of bed rest (+50% vs. control at day 26, P < 0.05), which tended to subside thereafter (+20% increase vs. control value at day 41, P < 0.05). VDI changes were associated with parallel changes in T1/2 (+54% vs. control at day 26 of bed rest, P < 0.05, and +25% vs. control at day 41, P < 0.05) and with a decrease in AFI (-49% at day 41 vs. P < 0.05). LV continuously decreased throughout bed rest (-13% vs. control at day 41, P < 0.05) but was correlated with VDI only during the first month of bed rest. These results show that during long-term 6 degrees head-down bed rest alterations of leg venous compliance are associated with impairment of venous emptying capacities and arterial flow. Changes in skeletal muscle mass and fluid shifts may account for venous changes during the first month of bed rest but, subsequently, other physiological factors, to be determined, may also be involved in leg venous hemodynamic alterations.
authors.affiliation: Departement de Physiologie Gravitationnelle, Institut de Médecine Aérospatiale du Service de Santé des Armées, Brétigny sur Orge, France.
authors.forename: F
authors.initials: F
authors.lastname: Louisy
authors.forename: P
authors.initials: P
authors.lastname: Schroiff
authors.forename: A
authors.initials: A
authors.lastname: Güell
mesh_terms: D000328:Adult; D001158:Arteries / Q000502:physiology; D001510:Bed Rest; D001810:Blood Volume; D003187:Compliance; D018475:Head-Down Tilt; D006801:Humans; D007866:Leg / Q000098:blood supply*; D008297:Male; D010991:Plethysmography; D012039:Regional Blood Flow; D013997:Time Factors; D014680:Veins / Q000502:physiology