title: Effects of calcium antagonists on insulin sensitivity and other metabolic parameters.
abstract: The antihypertensive efficacy of calcium antagonists appears to be comparable to that of oral diuretics when used as monotherapy. Peripheral vascular dilation appears to be the principal mechanism of the long-term blood pressure-lowering effects of calcium antagonists. The calcium antagonists appear to have beneficial effects with respect to maintenance of renal blood flow and glomerular filtration rate. Metabolic abnormalities associated with diuretic and beta-blocker antihypertensive therapy, such as hypokalemia, hypercalcemia, hyperuricemia, lipid changes, and hyperglycemia, are generally not observed with calcium antagonists.
authors.affiliation: Department of Internal Medicine, Wayne State University School of Medicine, Detroit, Michigon 48201, USA.
authors.forename: J R
authors.initials: JR
authors.lastname: Sowers
mesh_terms: D000959:Antihypertensive Agents / Q000494:pharmacology* / Q000627:therapeutic use; D002121:Calcium Channel Blockers / Q000494:pharmacology* / Q000627:therapeutic use; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism; D006801:Humans; D008660:Metabolism / Q000187:drug effects*; D012307:Risk Factors; D014664:Vasodilation / Q000187:drug effects
chemical_list: D000959:Antihypertensive Agents; D002121:Calcium Channel Blockers