title: Barrier recovery and influence of irritant stimuli in skin treated with a moisturizing cream.
abstract: Moisturizers are used daily by many people to alleviate symptoms of clinically and subjectively dry skin. Recent studies suggest that certain ingredients in creams may accelerate the recovery of a disrupted barrier and decrease the skin susceptibility to irritant stimuli. In the present single-blind study, a moisturizing cream was tested for its influence both on barrier recovery in surfactant-damaged skin and on the susceptibility of normal skin to exposure to the irritant sodium lauryl sulphate (SLS). Parameters measured were transepidermal water loss (TEWL) and skin corneometer values, indicating degree of hydration. Treatment of surfactant-damaged skin with the test cream for 14 days promoted barrier recovery, as observed as a decrease in TEWL. Skin corneometer values also normalized more rapidly during the treatment. In normal skin, use of the test cream significantly reduced TEWL after 14 days of treatment, and irritant reactions to SLS were significantly decreased. Skin corneometer values increased after only 1 application and remained elevated after 14 days. In conclusion, the accelerated rate of recovery of surfactant-damaged skin and the lower degree of SLS-induced irritation in normal skin treated with the test cream may be of clinical relevance in attempts to reduce contact dermatitis due to irritant stimuli.
authors.affiliation: Department of Dermatology, University Hospital, Uppsala, Sweden.
authors.forename: M
authors.initials: M
authors.lastname: Lodén
mesh_terms: D000328:Adult; D017453:Dermatitis, Irritant / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control*; D004643:Emollients / Q000494:pharmacology*; D005229:Fatty Acids, Monounsaturated / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D000074262:Rapeseed Oil; D012016:Reference Values; D016037:Single-Blind Method; D012867:Skin / Q000187:drug effects*; D012967:Sodium Dodecyl Sulfate / Q000009:adverse effects; D018709:Statistics, Nonparametric; D013501:Surface-Active Agents / Q000009:adverse effects; D014508:Urea / Q000494:pharmacology*; D014870:Water Loss, Insensible / Q000187:drug effects*
chemical_list: D004643:Emollients; D005229:Fatty Acids, Monounsaturated; D000074262:Rapeseed Oil; D013501:Surface-Active Agents; D012967:Sodium Dodecyl Sulfate; D014508:Urea