title: Myelodysplastic syndrome presenting with clonal rearrangement isolated to chromosomal region 1q.
abstract: Myelodysplastic syndrome (MDS) is a malignant hematologic disorder that may present with clinical features consistent with the diagnosis of severe aplastic anemia (SAA). Distinguishing the two disorders may depend on the presence of a clonal chromosomal abnormality. In the following, we report a case of MDS associated with what we believe to be a previously unreported clonal abnormality of chromosome 1q, a finding that enabled us to distinguish between MDS and SAA.
authors.affiliation: Division of Pediatric Hematology, Oncology, and Bone Marrow Transplant, Emory University School of Medicine, Atlanta, Georgia, 30322, USA.
authors.forename: M J
authors.initials: MJ
authors.lastname: Mogul
authors.forename: K
authors.initials: K
authors.lastname: Brady
authors.forename: A R
authors.initials: AR
authors.lastname: Brothman
authors.forename: R
authors.initials: R
authors.lastname: Adams
authors.forename: F B
authors.initials: FB
authors.lastname: Peterson
authors.forename: P G
authors.initials: PG
authors.lastname: Beatty
mesh_terms: D000328:Adult; D002869:Chromosome Aberrations; D002878:Chromosomes, Human, Pair 1; D005260:Female; D006801:Humans; D009190:Myelodysplastic Syndromes / Q000235:genetics*