Interleukin-6 production by human monocytes stimulated with Cryptococcus neoformans components.
In order to ascertain if Cryptococcus neoformans components can induce interleukin-6 (IL-6) production, we stimulated human whole blood with purified capsular products. Their potencies in stimulating IL-6 release were mannoproteins > galactoxylomannan = glucuronoxylomannan > alpha(1-3)glucan. IL-6 production was tumor necrosis factor alpha independent and required the presence of monocytes and plasma. Since IL-6 can stimulate replication of the human immunodeficiency virus in monocytic cells, these findings may be clinically relevant.
Delfino
D
D
Istituto di Microbiologia, Facoltà di Medicina e Chirurgia, Università degli Studi di Messina, Italy.
Cianci
L
L
Lupis
E
E
Celeste
A
A
Petrelli
M L
ML
Curró
F
F
Cusumano
V
V
Teti
G
G
D000163:Acquired Immunodeficiency Syndrome / Q000378:metabolism; D003455:Cryptococcus neoformans / Q000502:physiology*; D006801:Humans; D015850:Interleukin-6 / Q000096:biosynthesis*; D008562:Membrane Glycoproteins / Q000494:pharmacology; D009000:Monocytes / Q000378:metabolism*; D011134:Polysaccharides / Q000494:pharmacology; D011135:Polysaccharides, Bacterial / Q000494:pharmacology; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology
D015850:Interleukin-6; D008562:Membrane Glycoproteins; D011134:Polysaccharides; D011135:Polysaccharides, Bacterial; D014409:Tumor Necrosis Factor-alpha; C025363:mannoproteins; C043689:galactoxylomannan; C027478:glucuronoxylomannan