[Effects of steroids on hepatic ATP and L/P ratio in rats subjected to acute hemorrhage].
Both steroids and hemorrhage may affect the hepatic energy metabolism. The effects of steroids (5 mg.kg-1 of methylpredonisolone, 50 mg.kg-1 of methylpredonisolone, 25 mg.kg-1 of hydrocortisone and 250 mg.kg-1 of hydrocortisone) on hepatic ATP level and L/P ratio were evaluated in rats under acute hemorrhage. There were no significant differences in the hepatic ATP levels and L/P ratio among 5 groups. However, the base excess in 3 steroid groups (50 mg.kg-1 of methylpredonisolone, 25 mg.kg-1 of hydrocortisone and 250 mg.kg-1 of hydrocortisone) was significantly higher than that in the control group. This result suggests that steroids may improve the metabolic acidosis during acute hemorrhage.
Ikeya
K
K
Department of Anesthesiology, Yamanashi Medical University.
Kashimoto
S
S
Kume
M
M
Kumazawa
T
T
D000140:Acidosis, Lactic / Q000209:etiology / Q000517:prevention & control; D000208:Acute Disease; D000255:Adenosine Triphosphate / Q000378:metabolism*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D006003:Glycogen / Q000378:metabolism; D006470:Hemorrhage / Q000378:metabolism*; D006854:Hydrocortisone / Q000494:pharmacology*; D019344:Lactic Acid / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D008775:Methylprednisolone / Q000494:pharmacology*; D019289:Pyruvic Acid / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar
D000893:Anti-Inflammatory Agents; D019344:Lactic Acid; D019289:Pyruvic Acid; D000255:Adenosine Triphosphate; D006003:Glycogen; D006854:Hydrocortisone; D008775:Methylprednisolone