The origin of human chromosome 18 from a human/ape ancestor.
Karyotype analysis by previous investigators demonstrated that human chromosome 18 differs from homologous chromosomes in the great apes by a pericentric inversion. The present study uses fluorescence in situ hybridization on human and pygmy chimpanzee chromosomes to confirm the inversion and to delimit the regions where the breakpoints must have occurred in the human/ape ancestor.
McConkey
E H
EH
Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulde 80309, USA. mcconkey@stripe.colorado.edu
D000818:Animals; D002887:Chromosomes, Human, Pair 18; D015186:Hominidae / Q000235:genetics; D006801:Humans; D017404:In Situ Hybridization, Fluorescence