Interferon-gamma receptors in nociceptive pathways: role in neuropathic pain-related behaviour.
Interferon-gamma receptor (IFN-gamma R) immunoreactivity was observed in the superficial dorsal horn and lateral spinal nucleus in rat and mouse spinal cord. Dorsal rhizotomies did not reduce immunoreactivity in the rat. IFN-gamma R distribution overlapped with nitric oxide synthase-1 immunoreactivity. In wild-type mice, intrathecal injections of mouse IFN-gamma evoked biting behaviour, whereas mice with disruption of the functional gene for IFN-gamma R did not respond. Both types of mice had similar withdrawal thresholds to mechanical stimulation and reacted similarly to foot-pad carrageenan injections. In contrast to wild-type mice, IFN-gamma R knock-out mice did not show autotomy after sciatic nerve section. This study demonstrates a functional IFN-gamma R in spinal nociceptive pathways related to neuropathic pain.
Robertson
B
B
Department of Neuroscience, Karolinska Institute, Stockholm, Sweden.
Xu
X J
XJ
Hao
J X
JX
Wiesenfeld-Hallin
Z
Z
Mhlanga
J
J
Grant
G
G
Kristensson
K
K
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology*; D005260:Female; D007150:Immunohistochemistry; D007371:Interferon-gamma / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009434:Neural Pathways / Q000502:physiology; D009437:Neuralgia / Q000503:physiopathology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D017471:Receptors, Interferon / Q000502:physiology*; D011994:Recombinant Proteins; D013116:Spinal Cord / Q000503:physiopathology*; D009435:Synaptic Transmission / Q000502:physiology*
D017471:Receptors, Interferon; D011994:Recombinant Proteins; D007371:Interferon-gamma