Association of hereditary angioedema and hereditary breast cancer.
A family is presented in whom hereditary angioedema (HAE) and hereditary breast cancer were coexistent, an association not previously reported. A potential for genetic and treatment-related interactions between the two conditions exists. The use of the hormonal agent danazol to suppress HAE is unlikely to adversely affect the development or outcome of breast cancer. Surgery, chemotherapy, and radiotherapy were received by affected family members, without triggering edema. Whether hormonal breast cancer treatment affects the suppression of HAE by danazol remains unknown.
Christie
D R
DR
Division of Radiation Oncology, Westmead Hospital, NSW, Australia.
Kirk
J A
JA
Clarke
C L
CL
Boyages
J
J
D000368:Aged; D000799:Angioedema / Q000150:complications* / Q000517:prevention & control; D001943:Breast Neoplasms / Q000150:complications* / Q000235:genetics; D003613:Danazol / Q000627:therapeutic use*; D004965:Estrogen Antagonists / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D010375:Pedigree
D004965:Estrogen Antagonists; D003613:Danazol