[The effect of synthetic polycation of the quarternary ammonium salts of polymetacryoil lupinin on the ionic permeability of erythrocyte membrane].
It is shown that synthetic polycation quarternary ammonium salt polymetacryloil lupinine (poly-MACL) effects on passive ion permeability of erythrocytes membranes. The amplitude of Cl-/OH- exchange decreased in the buffer with SDS-polycation complex and simultaneously with pH elevation K+ exflux increased. On the contrary, in presence of heparin co-effect of poly-MACL and SDS vanished. Thus, synthetic polycation in the complex with long-chain anion (SDS) injure the membranes and effect depends on lipophilic-hydrophilic balance of polycation-SDS complex.
Makhsudova
G T
GT
Korepanova
E A
EA
Efimov
V S
VS
Vladimirov
Iu A
IuA
D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D002463:Cell Membrane Permeability / Q000187:drug effects*; D004910:Erythrocyte Membrane / Q000187:drug effects*; D006494:Heparin Antagonists / Q000494:pharmacology*; D066298:In Vitro Techniques; D051381:Rats; D012967:Sodium Dodecyl Sulfate / Q000494:pharmacology; D013034:Sparteine / Q000031:analogs & derivatives; D000093843:Quinolizidine Alkaloids
D000470:Alkaloids; D006494:Heparin Antagonists; D012967:Sodium Dodecyl Sulfate; D013034:Sparteine; C015971:lupinine; D000093843:Quinolizidine Alkaloids