A study of genetic association between manic-depressive illness and a highly polymorphic marker from the GABRbeta-1 gene.
We report on an association study between a tetranucleotide repeat polymorphism in the GABR beta1 gene and manic-depressive illness in a Spanish population. This gene may be an important candidate for bipolar affective disorders since severe GABergic alterations have been described in patients. Although our results do not reveal a clear evidence for association between manic-depressive illness and GABR beta1, we have found significant differences between patients and controls in the female subpopulation.
Puertollano
R
R
Centro de Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas, Universidad Autónoma de Madrid, Spain.
Visedo
G
G
Zapata
C
C
Fernández-Piqueras
J
J
D000483:Alleles; D001714:Bipolar Disorder / Q000235:genetics*; D004591:Electrophoresis, Polyacrylamide Gel; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D005838:Genotype; D006801:Humans; D008297:Male; D018895:Microsatellite Repeats / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D018079:Receptors, GABA / Q000235:genetics*; D013030:Spain
D005819:Genetic Markers; D018079:Receptors, GABA