title: The role of 15-lipoxygenase in atherogenesis: pro- and antiatherogenic actions.
abstract: Oxidative modification converts LDL to an atherogenic form and 15-lipoxygenase has been implicated in this process. Several lines of experimental evidence support such a proatherogenic action of the enzyme. However, recent data obtained with transgenic rabbits overexpressing 15-lipoxygenase suggest also an antiatherogenic effect. In this paper the pathophysiological relevance of 15-lipoxygenase in atherogenesis is critically reviewed.
authors.affiliation: Institute of Biochemistry, University Clinics Charité, Humboldt University, Berlin, Germany.
authors.forename: H
authors.initials: H
authors.lastname: Kühn
authors.forename: L
authors.initials: L
authors.lastname: Chan
mesh_terms: D000818:Animals; D001093:Arachidonate 15-Lipoxygenase / Q000235:genetics / Q000378:metabolism*; D001161:Arteriosclerosis / Q000201:enzymology*; D005786:Gene Expression Regulation; D006801:Humans
chemical_list: D001093:Arachidonate 15-Lipoxygenase