Open-chest cardiac massage without major thoracotomy: metabolic indicators of coronary and cerebral perfusion.
OBJECTIVE
To compare the coronary and cerebral perfusion achieved using a novel method of minimally-invasive, direct cardiac massage to that obtained using bimanual, open-chest cardiac massage.


METHODS
Prospective, controlled animal study with repeated measures.


METHODS
University research laboratory.


METHODS
Large domestic swine.


METHODS
Aortic, coronary sinus, jugular venous and pulmonary artery catheters were placed. Following an equilibration period, ventricular fibrillation was induced. After 4 min of untreated ventricular fibrillation, animals underwent bimanual, open-chest cardiac massage (N = 6) or minimally-invasive, direct cardiac massage using a novel device for direct cardiac compression (N = 6). Adrenaline was administered at a dose of 1 mg intravenously every 5 min.


METHODS
Systemic metabolic parameters, (arterial PO2, PCO2 and lactate concentration) and coronary sinus and jugular venous metabolic parameters (pH, PVO2, SVO2, PVCO2 and lactate concentration) were measured and calculated (coronary sinus/jugular-arterial SVO2, coronary sinus/jugular-arterial PCO2 and lactate differences) at baseline and at 10, 20 and 30 min following induction of ventricular fibrillation. Animals were euthanised after 30 min with no attempt at defibrillation.


RESULTS
Oxygen tension and oxygen saturation of coronary sinus blood declined significantly during the experimental period, but no differences were noted between treatment groups. The coronary sinus-arterial oxygen saturation difference increased during the study with no significant differences between groups. Coronary sinus PCO2 and the coronary sinus-arterial PCO2 difference increased significantly in both experimental groups during cardiac massage. No inter-group differences were noted. A similar relationship was noted in coronary sinus lactate values. The coronary sinus-arterial lactate difference displayed a positive balance at all intervals with no differences noted between group values. The oxygen tension and oxygen saturation of jugular venous blood, were reduced from baseline levels with both treatments. The jugular-arterial oxygen saturation difference increased in both groups compared to baseline values. Between group values were significantly different only at the 20 min interval. Both the jugular venous PCO2 and the jugular-arterial PCO2 gradient were elevated at all intervals, but no inter-group differences were noted. Jugular venous lactate concentration rose steadily with time in both groups. No significant increase in the jugular-arterial lactate gradient was noted at any time point.


CONCLUSIONS
Minimally-invasive, direct cardiac massage provides coronary and cerebral perfusion similar to that achieved using standard open-chest cardiac massage. This method may provide a more effective substitute for standard, closed-chest cardiac massage in cases of refractory cardiac arrest.
Buckman
R F
RF
Department of Surgery, Temple University School of Medicine, Philadelphia, PA 19140, USA.
Badellino
M M
MM
Eynon
C A
CA
Mauro
L H
LH
Aldridge
S C
SC
Milner
R E
RE
Merchant
N B
NB
Buckman
R F
RF
Mercer
D
D
Malaspina
P J
PJ
Warren
R
R
D000818:Animals; D015415:Biomarkers; D001769:Blood / Q000378:metabolism; D002245:Carbon Dioxide / Q000097:blood; D002560:Cerebrovascular Circulation; D003326:Coronary Circulation; D006336:Heart Massage / Q000379:methods*; D006863:Hydrogen-Ion Concentration; D019344:Lactic Acid / Q000097:blood; D010100:Oxygen / Q000097:blood; D011446:Prospective Studies; D013552:Swine; D013908:Thoracotomy
D015415:Biomarkers; D002245:Carbon Dioxide; D019344:Lactic Acid; D010100:Oxygen