Two new nitrogenous sesquiterpenes from the sponge Axinyssa aplysinoides.
Bioassay-guided fractionation of the EtOAc extract of the Palauan sponge Axinyssa aplysinoides yielded two novel alkaloids, 1 and 2. The structure of 2-(formylamino)trachyopsane (1) was determined by X-ray analysis; and the structure of N-phenethyl-N'-2-trachyopsanylurea (2), by interpretation of the spectral data.
Patil
A D
AD
Department of Biomolecular Discovery, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406-0939, USA.
Freyer
A J
AJ
Reichwein
R
R
Bean
M F
MF
Faucette
L
L
Johnson
R K
RK
Haltiwanger
R C
RC
Eggleston
D S
DS
D016587:Antimutagenic Agents / Q000302:isolation & purification* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D004249:DNA Damage; D004260:DNA Repair / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism; D012717:Sesquiterpenes / Q000302:isolation & purification* / Q000494:pharmacology; D016339:Spectrometry, Mass, Fast Atom Bombardment; D014508:Urea / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology
C106395:2-(formylamino)trachyopsane; D016587:Antimutagenic Agents; C106396:N-phenethyl-N'-2-trachyopsanylurea; D012717:Sesquiterpenes; D014508:Urea