[The use of low heparin doses for the prevention of postoperative thrombosis of the deep veins and of pulmonary artery thromboembolism].
The results of small doses heparin application (15,000 units) for the prophylaxis of postoperative deep vein thrombosis and the pulmonary artery thromboembolism were analyzed. The lowering of incidence of deep vein thrombosis from 32 to 8% was determined using 125I-fibrinogen. Of 3540 patients aged 40 years old and more, while the operation duration no less than 1 hour and anticoagulant administered, 6 (0.16%) died due to the pulmonary artery thromboembolism. The mortality was 9 times more in the group of patients, whom the prophylaxis was not conducted. Severe hemorrhagic complications after heparin application in above mentioned dose were not noted.
Shorokh
G P
GP
Baeshko
A A
AA
D000925:Anticoagulants / Q000008:administration & dosage* / Q000009:adverse effects; D000075202:Contraindications; D004305:Dose-Response Relationship, Drug; D006493:Heparin / Q000008:administration & dosage* / Q000009:adverse effects; D006801:Humans; D007457:Iodine Radioisotopes; D011183:Postoperative Complications / Q000000981:diagnostic imaging / Q000517:prevention & control*; D019106:Postoperative Hemorrhage / Q000139:chemically induced; D011655:Pulmonary Embolism / Q000000981:diagnostic imaging / Q000517:prevention & control*; D011877:Radionuclide Imaging; D012086:Reoperation; D013924:Thrombophlebitis / Q000000981:diagnostic imaging / Q000517:prevention & control*; D013997:Time Factors
D000925:Anticoagulants; D007457:Iodine Radioisotopes; D006493:Heparin