title: Increase of staphylococci in neonatal septicaemia: a fourteen-year study.
abstract: All cases of neonatal septicaemia during 1981-94 were studied at Orebro Medical Centre Hospital, Sweden. One hundred and thirty-two children fulfilled laboratory and clinical criteria for neonatal septicaemia and were included. Staphylococcus aureus (n = 41), Group B streptococcus (GBS) (n = 32) and coagulase-negative staphylococci (CoNS) (n = 27) were the dominating aetiologies. The annual incidence of septicaemia increased significantly, from 2.3 cases during the first 7-year period to 3.3 per 1000 live births during 1988-94. This increase was caused by S. aureus and CoNS, which mainly affected premature children and had an onset more than 48 h after delivery. GBS, on the other hand, slightly decreased and affected full-term children within 48 h. The overall mortality was 11%. CoNS isolated during the latter 7-year period were more resistant to antibiotics than those isolated during 1981-87; resistance to methicillin increased from 14 to 45% and to gentamicin from 0 to 20%. These changes in aetiology and antibiotic susceptibility should be considered when selecting antibiotic treatment in neonatal septicaemia.
authors.affiliation: Department of Infectious Diseases, Orebro Medical Centre Hospital, Sweden.
authors.forename: J
authors.initials: J
authors.lastname: Källman
authors.forename: E
authors.initials: E
authors.lastname: Kihlström
authors.forename: L
authors.initials: L
authors.lastname: Sjöberg
authors.forename: J
authors.initials: J
authors.lastname: Schollin
mesh_terms: D000046:Academic Medical Centers; D016470:Bacteremia / Q000382:microbiology*; D003428:Cross Infection / Q000382:microbiology*; D004352:Drug Resistance, Microbial; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D011446:Prospective Studies; D013203:Staphylococcal Infections / Q000382:microbiology*; D013211:Staphylococcus aureus; D013290:Streptococcal Infections / Q000382:microbiology*; D013292:Streptococcus agalactiae; D016019:Survival Analysis; D013548:Sweden