title: Quality of life in patients stented for malignant biliary obstructions.
abstract: OBJECTIVE
  Endoscopic stent placement is the standard treatment for patients with extrahepatic malignant biliary strictures (EMBS) who are too frail to undergo surgical resection. Stenting relieves jaundice and pruritus but the effects upon other systemic symptoms and quality of life (QOL) are not known.
  
  
  METHODS
  Forty-seven patients (age: 46-89 years) with jaundice due to EMBS completed the European Organisation for Research and Treatment of Cancer QOL questionnaire, EORTC QLQ-C30, and two further questions assessing jaundice and pruritus, at the time of diagnosis and 1 month after endoscopic stenting. Thirty-eight patients successfully completed the study; nine patients succumbed to their illness within a month.
  
  
  RESULTS
  No significant difference was found in the baseline QOL measurements and liver function tests between those patients who completed the study and those who were either too weak to answer the questionnaire or died within the first month of stenting. For patients who successfully completed follow-up, liver function tests (apart from serum albumin) improved after stenting. They also reported significant improvement in emotional, cognitive and global health scores (P < 0.01). In addition to the expected improvement in pruritus and jaundice (P < 0.01), anorexia, diarrhoea and sleep pattern were also reported to be improved (P < 0.01).
  
  
  CONCLUSIONS
  Endoscopic stent insertion considerably improves a range of symptoms and enhances quality of life.
authors.affiliation: Gastrointestinal Unit, Western General Hospital, Edinburgh, UK.
authors.forename: W
authors.initials: W
authors.lastname: Luman
authors.forename: A
authors.initials: A
authors.lastname: Cull
authors.forename: K R
authors.initials: KR
authors.lastname: Palmer
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D014670:Ampulla of Vater; D001653:Bile Ducts, Intrahepatic; D018281:Cholangiocarcinoma / Q000150:complications; D002760:Cholangiopancreatography, Endoscopic Retrograde; D001651:Cholestasis, Extrahepatic / Q000209:etiology / Q000523:psychology* / Q000601:surgery; D003138:Common Bile Duct Neoplasms / Q000150:complications / Q000175:diagnosis; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000150:complications / Q000175:diagnosis; D011788:Quality of Life; D012189:Retrospective Studies; D015607:Stents; D011795:Surveys and Questionnaires; D015996:Survival Rate