title: Synchronous and metachronous carcinomas of the esophagus and head and neck.
abstract: We retrospectively analyzed the clinicopathologic findings, treatment and outcome of 22 patients with synchronous or metachronous carcinomas of the esophagus and head and neck. The patients with metachronous cancers in whom esophageal cancer occurred first had either an early-stage esophageal carcinoma or only one positive lymph node. Similarly, five of 10 patients with metachronous cancers in whom head and neck cancer was the first tumor had early-stage esophageal carcinomas. The esophageal lesion was mucosal carcinoma in four patients which was found by endoscopy with the iodine dye method. In the patients with synchronous cancers either one or both carcinomas were advanced, and the prognosis of these patients was poor compared with those of patients with metachronous carcinomas. Accordingly, endoscopic surveillance for early detection of metachronous lesions are encouraged.
authors.affiliation: First Department of Surgery, Kagoshima Univesity School of Medicine, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Natsugoe
authors.forename: Y
authors.initials: Y
authors.lastname: Uchino
authors.forename: F
authors.initials: F
authors.lastname: Kijima
authors.forename: M
authors.initials: M
authors.lastname: Shimada
authors.forename: K
authors.initials: K
authors.lastname: Shirao
authors.forename: C
authors.initials: C
authors.lastname: Kusano
authors.forename: M
authors.initials: M
authors.lastname: Baba
authors.forename: H
authors.initials: H
authors.lastname: Yoshinaka
authors.forename: T
authors.initials: T
authors.lastname: Fukumoto
authors.forename: J
authors.initials: J
authors.lastname: Mueller
authors.forename: H J
authors.initials: HJ
authors.lastname: Stein
authors.forename: T
authors.initials: T
authors.lastname: Aikou
mesh_terms: D000328:Adult; D000368:Aged; D000428:Alcohol Drinking / Q000009:adverse effects; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000473:pathology* / Q000628:therapy; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006258:Head and Neck Neoplasms / Q000401:mortality / Q000473:pathology* / Q000628:therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000401:mortality / Q000473:pathology* / Q000628:therapy; D016609:Neoplasms, Second Primary / Q000401:mortality / Q000473:pathology* / Q000628:therapy; D012907:Smoking / Q000009:adverse effects; D015996:Survival Rate