Effects of the synergistic action of febantel and pyrantel on the nematode Heterakis spumosa: a light and transmission electron microscopy study.
The present study proved that combined administration of pyrantel and febantel to Heterakis spumosa-infected mice yielded clear synergistic effects (seen in a quicker expulsion of the worms and a significant higher degree of worm degeneration), whereas the different doses of both drugs never reached the same efficacy, when given alone. It is concluded that the synergistic action of pyrantel and febantel on the functions of different organs of the parasites (muscle, nerve, inertine etc.) seen in the rodent model - also holds for the gut dwelling nematodes of the dog.
Mehlhorn
H
H
Institute of Zoomorphology, Cell Biology and Parasitology, Heinrich-Heine-University Düsseldorf, Germany.
Harder
A
A
D000818:Animals; D000969:Antinematodal Agents / Q000494:pharmacology / Q000627:therapeutic use*; D017162:Ascaridida / Q000187:drug effects* / Q000648:ultrastructure; D017191:Ascaridida Infections / Q000188:drug therapy / Q000469:parasitology*; D004195:Disease Models, Animal; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D006146:Guanidines / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D008854:Microscopy, Electron; D011715:Pyrantel / Q000494:pharmacology / Q000627:therapeutic use*
D000969:Antinematodal Agents; D006146:Guanidines; D011715:Pyrantel; C017309:febantel