Isolation and characterization of new anti-HIV and cytotoxic leads from plants, marine, and microbial organisms.
New cytotoxic isomalabaricane triterpenes have been isolated from a sponge Stelletta sp. (1-7); anti-HIV pterocarpans (8 and 9) and isoflavanoids (12-16 and 18) were elucidated from two tropical plants in the genus Erythrina; and anti-HIV enniatins (20 and 22-23) were characterized from fungi in the genera Fusarium and Alternaria. The enniatins were evaluated for in vivo anti-HIV activity in the hollow fiber assay.
McKee
T C
TC
Laboratory of Drug Discovery Research and Development, National Cancer Institute, Frederick, Maryland 21702-1201, USA.
Bokesch
H R
HR
McCormick
J L
JL
Rashid
M A
MA
Spielvogel
D
D
Gustafson
K R
KR
Alavanja
M M
MM
Cardelline
J H
JH
Boyd
M R
MR
D000528:Alternaria / Q000737:chemistry; D000818:Animals; D019380:Anti-HIV Agents / Q000302:isolation & purification* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000302:isolation & purification* / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005670:Fusarium / Q000737:chemistry; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D010946:Plants, Medicinal / Q000737:chemistry*; D011753:Pyrones / Q000302:isolation & purification / Q000494:pharmacology; D014315:Triterpenes / Q000302:isolation & purification* / Q000494:pharmacology
D019380:Anti-HIV Agents; D000970:Antineoplastic Agents; D000972:Antineoplastic Agents, Phytogenic; D011753:Pyrones; D014315:Triterpenes