Endometrial carcinoma in 45,X Turner's syndrome without hormone replacement therapy.
An endometrial carcinoma developing in a patient with pure Turner's syndrome was described. The patient showed typical Turner's phenotype and analysis of karyotype revealed only 45,X. Secondary sexual development had been seen until age 20 and she had no history of hormone replacement therapy (HRT). The enlarged uterus and normal appearance of bilateral ovaries were detected at laparotomy. A well-differentiated adenocarcinoma of the endometrium and a graafian follicle of the left ovary were histologically confirmed. This seems to be the first report of the occurrence of endometrial carcinoma in possibly pure Turner's syndrome without HRT.
Matsui
H
H
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Chiba, Chuo-ku, Japan.
Ishii
J
J
Onodera
T
T
Takano
H
H
Seki
K
K
Sekiya
S
S
D000328:Adult; D016889:Endometrial Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000235:genetics; D015914:Estrogen Replacement Therapy; D005260:Female; D006801:Humans; D007621:Karyotyping; D014424:Turner Syndrome / Q000150:complications* / Q000175:diagnosis / Q000235:genetics