title: Post-weaning housing conditions influence the behavioural effects of cocaine and d-amphetamine.
abstract: Post-weaning social isolation can induce profound and long lasting effects on an animal's behaviour. The present study investigated the influence of post-weaning housing conditions on the sensitivity of rats to the behavioural effects of d-amphetamine and cocaine. The locomotor stimulant effects of both drugs were compared following acute and chronic administration. The influence of post-weaning housing conditions on the effects of d-amphetamine and cocaine on responding for food and for a conditioned reinforcer were also examined. Isolated rats showed enhanced locomotor activity on exposure to a novel environment. This difference was further exaggerated following administration of d-amphetamine (0.5 mg/kg) and cocaine (5 mg/kg). Isolated, but not enriched, rats exhibited sensitisation to the locomotor activating effects of repeated administration of a dose of 0.5 mg/kg d-amphetamine, whilst both groups sensitised equally to a dose of 1.0 mg/kg d-amphetamine. Rearing conditions did not affect sensitisation to cocaine (5, 10 mg/kg). Isolated rats exhibited a higher rate of responding for a conditioned stimulus and for food on a progressive ratio schedule of reinforcement, both of which were enhanced to a greater extent in isolates following administration of cocaine (5 mg/kg) and d-amphetamine (0.5 mg/kg). These results suggest that isolation rearing induces an enhancement in sensitivity to both the locomotor stimulant and reinforcing properties of amphetamine and cocaine.
authors.affiliation: School of Pharmacy, University of Bradford, West Yorkshire, UK.
authors.forename: J K
authors.initials: JK
authors.lastname: Smith
authors.forename: J C
authors.initials: JC
authors.lastname: Neill
authors.forename: B
authors.initials: B
authors.lastname: Costall
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D003042:Cocaine / Q000494:pharmacology*; D003913:Dextroamphetamine / Q000494:pharmacology*; D005260:Female; D008124:Locomotion / Q000187:drug effects; D051381:Rats; D012680:Sensitivity and Specificity; D012934:Social Isolation
chemical_list: D003042:Cocaine; D003913:Dextroamphetamine