Localized myofibroblastic proliferation in the neck of a patient with an IgG myeloma.
We describe a myofibroblastic proliferation in the neck and lower part of the face involving skin and muscle of a 68-year-old female patient with an IgG kappa myeloma. Biopsies showed a fusocellular proliferation with scarce pseudoganglion cells involving the superficial fascia and the cutaneous muscle of the neck. The proliferative cells showed immunohistochemical and ultrastructural features characteristic of myofibrobasts with a proliferating cell nuclear antigen index of 48%; 42% of the cells displayed HLADR-positive membrane staining. Cellular proliferation subsided following the use of immunosuppressive drugs. Eight months after initial consultation, the patient developed polymyositis without a proliferative component and died of aplastic anemia.
Reissenweber
N
N
Department of Pathology, Hospital de Clínicas Dr. Manuel Quintela, Montevideo, Uruguay.
Panuncio
A L
AL
De Anda
G
G
D000368:Aged; D034961:Antigens, Nuclear; D001324:Autoantigens / Q000032:analysis; D005260:Female; D006258:Head and Neck Neoplasms / Q000473:pathology* / Q000648:ultrastructure; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis*; D009132:Muscles / Q000473:pathology; D009687:Nuclear Proteins / Q000032:analysis; D010954:Plasmacytoma / Q000473:pathology* / Q000648:ultrastructure; D017285:Polymyositis / Q000150:complications
D034961:Antigens, Nuclear; D001324:Autoantigens; D007074:Immunoglobulin G; D009687:Nuclear Proteins