title: Assignment of human membrane-type matrix metalloproteinase-2 (MT2-MMP) gene to 16q12 by FISH and PCR-based human/rodent cell hybrid mapping panel analysis.
abstract: A new group of matrix metalloproteinase with a potential membrane domain was reported as membrane-type matrix metalloproteinases (MT-MMPs), and the gene coding for one of them, MT2-MMP was recently cloned from a human lung cDNA library. To predict its physiological functions by the relation to the genetic disorders mapped on the chromosomes, the chromosomal location of the human MT2-MMP gene was examined by fluorescence in situ hybridization (FISH) and PCR-based analysis with human/rodent hybrid cell mapping panels, and it was assigned to 16q12.
authors.affiliation: Division of Cell Biology, Kihara Institute for Biological Research, Yokohama City University, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Yasumitsu
authors.forename: K
authors.initials: K
authors.lastname: Shofuda
authors.forename: A
authors.initials: A
authors.lastname: Nishihashi
authors.forename: T
authors.initials: T
authors.lastname: Eki
authors.forename: N
authors.initials: N
authors.lastname: Koshikawa
authors.forename: H
authors.initials: H
authors.lastname: Mizushima
authors.forename: K
authors.initials: K
authors.lastname: Miyazaki
mesh_terms: D000818:Animals; D002874:Chromosome Mapping / Q000379:methods*; D002885:Chromosomes, Human, Pair 16; D006801:Humans; D006822:Hybrid Cells; D017404:In Situ Hybridization, Fluorescence; D053517:Matrix Metalloproteinase 15; D053504:Matrix Metalloproteinases, Membrane-Associated; D008666:Metalloendopeptidases / Q000235:genetics*; D016133:Polymerase Chain Reaction / Q000379:methods; D012377:Rodentia
chemical_list: C507098:MMP15 protein, human; D053517:Matrix Metalloproteinase 15; D053504:Matrix Metalloproteinases, Membrane-Associated; D008666:Metalloendopeptidases