[The influence of selected antibiotics on the central action of aminophyllines--experimental studies].
Methylxanthines and some antibiotics can cause side effects, provoked by their central action, e.g. seizures. The epileptogenic effects of given drugs can be intensified during combined treatment, as a result of pharmacological interactions. In the present study the author investigated the influence of some commonly used antibiotics: benzylpenicillin, cefuroxime, doxycycline and amikacin upon central activity of methylxanthines in mice. The obtained results suggest, that all tested antibiotics, mainly benzylpenicillin, enhanced epileptogenicity of aminophylline in chemical seizures test. benzylpenicillin as only one among chosen antibiotics presented her own convulsant activity. During electrostimulation test, benzylpenicillin, doxycycline and amikacin intensified convulsions induced by methylxanthines. Only cefuroxime had no influence upon central action of methylxanthines in that experiments. Analysis of drugs' plasma levels, with using immunofluorescence methods, excluded pharmacokinetic interactions between them. Results of present investigation indicate, that there is a possibility of intensification of drugs' convulsant activity during combined treatment-aminophylline with some antibiotics in medical practice.
Szmygin
K
K
Katedry i Kliniki Chorób Płuc i Gruzlicy, Akademii Medycznej w Lublinie.
D000583:Amikacin / Q000493:pharmacokinetics / Q000494:pharmacology; D000628:Aminophylline / Q000493:pharmacokinetics / Q000633:toxicity*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics / Q000494:pharmacology*; D002444:Cefuroxime / Q000493:pharmacokinetics / Q000494:pharmacology; D003292:Convulsants / Q000493:pharmacokinetics / Q000494:pharmacology*; D004318:Doxycycline / Q000493:pharmacokinetics / Q000494:pharmacology; D004347:Drug Interactions; D004597:Electroshock; D005260:Female; D051379:Mice; D010400:Penicillin G / Q000493:pharmacokinetics / Q000494:pharmacology*; D012640:Seizures / Q000139:chemically induced*
D000900:Anti-Bacterial Agents; D003292:Convulsants; D000628:Aminophylline; D000583:Amikacin; D004318:Doxycycline; D002444:Cefuroxime; D010400:Penicillin G