Structure-based design of peptides that inhibit IgE binding to its high-affinity receptor Fc epsilon RI.
McDonnell
J M
JM
Randall Institute, King's College London, U.K.
Beavil
A J
AJ
Mackay
G A
GA
Henry
A J
AJ
Cook
J P
JP
Gould
H J
HJ
Sutton
B J
BJ
D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D015195:Drug Design; D006801:Humans; D007073:Immunoglobulin E / Q000737:chemistry / Q000378:metabolism*; D007700:Kinetics; D008961:Models, Structural; D016297:Mutagenesis, Site-Directed; D009842:Oligopeptides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D017354:Point Mutation; D017433:Protein Structure, Secondary; D017455:Receptors, IgE / Q000037:antagonists & inhibitors* / Q000737:chemistry; D011994:Recombinant Proteins / Q000737:chemistry / Q000378:metabolism
D009842:Oligopeptides; D017455:Receptors, IgE; D011994:Recombinant Proteins; D007073:Immunoglobulin E