title: Magnesium deficiency induces an hyperalgesia reversed by the NMDA receptor antagonist MK801.
abstract: The aim of this study was to determine the changes of the nociceptive thresholds in response to an acute mechanical stimulus (paw pressure) in magnesium (Mg)-deficient rats, and the involvement of the NMDA receptor in these changes. Changes in vocalization thresholds was determined after 7 days of feeding with a Mg-depleted diet. Compared with the control group, Mg-deficient rats showed a significant decrease in the vocalization thresholds (-35.8 +/- 2.5%, p < 0.001) reflecting hyperalgesia. In Mg-deprived rats, three doses (0.06, 0.12 and 0.24 mg/kg s.c.) of dizocilpine (MK801), a non-competitive NMDA receptor antagonist, significantly reversed the hyperalgesia in a dose-dependent manner for at least 48 h. No effect of MK801 was observed in the control group. These data provide evidence that Mg deficiency could constitute a new model of hyperalgesia involving NMDA receptors.
authors.affiliation: Groupe NPPUA, Faculté de Médecine, Clermont-Ferrand, France.
authors.forename: C
authors.initials: C
authors.lastname: Dubray
authors.forename: A
authors.initials: A
authors.lastname: Alloui
authors.forename: L
authors.initials: L
authors.lastname: Bardin
authors.forename: E
authors.initials: E
authors.lastname: Rock
authors.forename: A
authors.initials: A
authors.lastname: Mazur
authors.forename: Y
authors.initials: Y
authors.lastname: Rayssiguier
authors.forename: A
authors.initials: A
authors.lastname: Eschalier
authors.forename: J
authors.initials: J
authors.lastname: Lavarenne
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D016291:Dizocilpine Maleate / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology*; D006930:Hyperalgesia / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D008275:Magnesium Deficiency / Q000503:physiopathology*; D008297:Male; D017288:Pain Threshold / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors*; D013314:Stress, Mechanical
chemical_list: D018691:Excitatory Amino Acid Antagonists; D016194:Receptors, N-Methyl-D-Aspartate; D016291:Dizocilpine Maleate