[Cytotoxic properties of the complex of the antineoplastic antibiotic bleomycetin and Bacillus intermedius ribonuclease].
It was shown possible to change the cytotoxic properties of the antitumor antibiotic bleomycetin by its binding to Bacillus intermedius RNAse. The complexing lowered the antibiotic effect on DNA in the cells of the human amnion. At the same time the experiments with human red blood cells indicated that RNAse of B. intermedius in complex with bleomycetin-Fe(II) increased the antibiotic capacity for the cell membrane break down.
Kalacheva
N V
NV
Bulgakova
R Sh
RSh
Kazantseva
N Iu
NIu
Kurinenko
B M
BM
D000650:Amnion / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D000903:Antibiotics, Antineoplastic / Q000737:chemistry / Q000627:therapeutic use*; D001407:Bacillus / Q000201:enzymology*; D001761:Bleomycin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000627:therapeutic use; D002460:Cell Line; D002462:Cell Membrane / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004247:DNA / Q000096:biosynthesis; D004910:Erythrocyte Membrane / Q000187:drug effects; D006801:Humans; D015394:Molecular Structure; D012313:RNA / Q000096:biosynthesis; D012260:Ribonucleases / Q000737:chemistry*
D000903:Antibiotics, Antineoplastic; D001761:Bleomycin; C025703:bleomycetin; D012313:RNA; D004247:DNA; D012260:Ribonucleases