Medicinal foodstuffs. VI. 1) Histamine release inhibitors from kidney bean, the seeds of Phaseolus vulgaris L.: chemical structures of sandosaponins A and B.
Two new olean-12-ene-type triterpene oligoglycosides, named sandosaponins A and B, were isolated from kidney bean, the seed of Phaseolus vulgaris L., together with three known saponins, soyasaponins I and V and dehydrosoyasaponin 1. The structures of sandosaponins A and B were determined on the basis of chemical and physicochemical evidence, which included the chemical derivation of sandosapogenol from a known sapogenol, soyasapogenol B. Five saponins obtained from kidney bean were found to inhibit histamine release from rat exudate cells induced by an antigen-antibody reaction and, among them, sandosaponins A and B showed the most potent inhibitory activity.
Yoshikawa
M
M
Kyoto Pharmaceutical University, Japan.
Shimada
H
H
Komatsu
H
H
Sakurama
T
T
Nishida
N
N
Yamahara
J
J
Shimoda
H
H
Matsuda
H
H
Tani
T
T
D000818:Animals; D002240:Carbohydrate Sequence; D005122:Exudates and Transudates / Q000378:metabolism; D007887:Fabaceae / Q000737:chemistry*; D006633:Histamine Antagonists / Q000302:isolation & purification* / Q000494:pharmacology; D006636:Histamine Release / Q000187:drug effects; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008969:Molecular Sequence Data; D009828:Oleanolic Acid / Q000031:analogs & derivatives*; D010529:Peritoneal Cavity / Q000166:cytology; D010946:Plants, Medicinal; D051381:Rats; D017208:Rats, Wistar; D012503:Saponins / Q000302:isolation & purification* / Q000494:pharmacology; D012639:Seeds / Q000737:chemistry
D006633:Histamine Antagonists; D012503:Saponins; C106688:sandosaponin A; C106689:sandosaponin B; D009828:Oleanolic Acid