Activation of phosphatidylinositol 3-kinase following Fas engagement is not required for Fas-mediated apoptosis in Jurkat T cells.
McLeod
J D
JD
Bath Institute for Rheumatic Diseases, Great Britain.
Walker
L S
LS
Parry
R V
RV
Ward
S G
SG
Sansom
D M
DM
D000730:Androstadienes / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects; D002867:Chromones / Q000494:pharmacology; D004789:Enzyme Activation; D004791:Enzyme Inhibitors / Q000494:pharmacology; D053222:Fas Ligand Protein; D006801:Humans; D015544:Inositol 1,4,5-Trisphosphate / Q000378:metabolism; D019169:Jurkat Cells; D007700:Kinetics; D008562:Membrane Glycoproteins / Q000494:pharmacology; D009025:Morpholines / Q000494:pharmacology; D019869:Phosphatidylinositol 3-Kinases; D010741:Phospholipases A / Q000037:antagonists & inhibitors; D017853:Phosphotransferases (Alcohol Group Acceptor) / Q000378:metabolism*; D015398:Signal Transduction; D013601:T-Lymphocytes; D013997:Time Factors; D000077191:Wortmannin; D019014:fas Receptor / Q000502:physiology*
D000730:Androstadienes; D002867:Chromones; D004791:Enzyme Inhibitors; C505661:FASLG protein, human; D053222:Fas Ligand Protein; D008562:Membrane Glycoproteins; D009025:Morpholines; D019014:fas Receptor; C085911:2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one; D015544:Inositol 1,4,5-Trisphosphate; D019869:Phosphatidylinositol 3-Kinases; D017853:Phosphotransferases (Alcohol Group Acceptor); D010741:Phospholipases A; D000077191:Wortmannin