title: Genetic and physical delineation of the region of the mouse deafness mutation shaker-2.
abstract: A total of 951 backcross progeny have been obtained from a backcross segregating for the mouse deafness mutation, shaker-2(sh-2). Linkage analysis provides a detailed genetic map in the vicinity of sh-2 which comprises 40 backcross mice identified as recombinant within a 4 cM region. This allows construction of a contig consisting of 21 BAC clones across an approximately 700-kb region of sh-2. This covers the entire nonrecombinant region of sh-2 and is therefore useful to facilitate the identification of genes in the sh-2 region.
authors.affiliation: First Department of Biochemistry, Niigata University School of Medicine, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Wakabayashi
authors.forename: Y
authors.initials: Y
authors.lastname: Kikkawa
authors.forename: Y
authors.initials: Y
authors.lastname: Matsumoto
authors.forename: T
authors.initials: T
authors.lastname: Shinbo
authors.forename: S
authors.initials: S
authors.lastname: Kosugi
authors.forename: D
authors.initials: D
authors.lastname: Chou
authors.forename: M
authors.initials: M
authors.lastname: Furuya
authors.forename: K
authors.initials: K
authors.lastname: Jishage
authors.forename: T
authors.initials: T
authors.lastname: Noda
authors.forename: H
authors.initials: H
authors.lastname: Yonekawa
authors.forename: R
authors.initials: R
authors.lastname: Kominami
mesh_terms: D000818:Animals; D002874:Chromosome Mapping; D016386:Chromosome Walking; D018244:Chromosomes, Artificial, Yeast; D003001:Cloning, Molecular; D003433:Crosses, Genetic; D003638:Deafness / Q000235:genetics*; D005808:Genes, Recessive; D008040:Genetic Linkage / Q000235:genetics; D006239:Haplotypes / Q000235:genetics; D051379:Mice; D008817:Mice, Mutant Strains; D009154:Mutation; D016133:Polymerase Chain Reaction