The frequency of autoantibodies in Turkish patients with lupus nephritis.
We analysed the frequency of autoantibodies in 44 patients with lupus nephritis. Antinuclear antibody (ANA) was found in 91% of patients by an indirect immunofluorescence technique on HEp-2 cells at the time of study. Anti-dsDNA antibodies were found at high levels in most of the patients using the SynELISA test, which reveals both high and low avidity antibodies, but only in 64% of patients using the DAKO assay, which reveals high avidity antibodies. Anti-histone antibodies were found in 52% of the patients. Anti-SSA/Ro antibodies were positive in 27% of all patients; these patients also had prominent cutaneous involvement and photosensitivity. The frequency of anti-SSB/La and Anti-Sm antibodies was 7%. Immunoblotting experiments confirmed the findings shown by the techniques described above, and anti-ribosomal antibodies were found to be positive in more cases by the latter assay. IgA rheumatoid factor (RF) was more frequent (20.4%) than IgM RF (9.9%). In conclusion, Turkish patients suffering from lupus nephritis seem to express a total autoantibody profile similar to that reported for systemic lupus erythematosus from other parts of Europe.
Düzgün
N
N
Department of Immunology, Faculty of Medicine, Ankara University, Turkey.
Hoier-Madsen
M
M
Wiik
A
A
Tokgöz
G
G
D000293:Adolescent; D000328:Adult; D000974:Antibodies, Antinuclear / Q000097:blood*; D001323:Autoantibodies / Q000097:blood*; D005260:Female; D006801:Humans; D008181:Lupus Nephritis / Q000097:blood / Q000453:epidemiology / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D014421:Turkey / Q000453:epidemiology
D000974:Antibodies, Antinuclear; D001323:Autoantibodies