Proliferating cell nuclear antigen expression in the gallbladder with pancreaticobiliary maljunction.
OBJECTIVE
To clarify the histogenesis of cancer of the gallbladder of the patients with pancreaticobiliary maljunction (PBMJ), the proliferating cell activity of the epithelium of gallbladder was examined.


METHODS
A total of 21 patients with pancreaticobiliary maljunction [8 with gallbladder cancer (MCA group) and 13 without cancer (M group)] were studied using immunohistochemical staining with a monoclonal antibody to the proliferating cell nuclear antigen (PCNA). The 23 gallbladder cancer patients without PBMJ (CA group) and 10 patients with normal gallbladders (N group) were also examined as controls.


RESULTS
The PCNA-positive rates of non-cancerous epithelium of the gallbladder in patients with PBMJ (14.2% in MCA group and 11.6% in M group) were significantly higher than those without PBMJ (3.9% in CA group and 1.5% in N group).


CONCLUSIONS
The high proliferating cell activity of epithelium of the gallbladder may be an explantation for the high incidence of gallbladder cancer in patients with pancreaticobiliary maljunction.
Isozaki
H
H
Department of General and Gastroenterological Surgery, Osaka Medical College, Japan.
Okajima
K
K
Hara
H
H
Sako
S
S
Mabuchi
H
H
D000368:Aged; D001652:Bile Ducts / Q000002:abnormalities*; D004848:Epithelium / Q000378:metabolism; D005260:Female; D005704:Gallbladder / Q000378:metabolism*; D005706:Gallbladder Neoplasms / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D010183:Pancreatic Ducts / Q000002:abnormalities*; D018809:Proliferating Cell Nuclear Antigen / Q000378:metabolism*
D018809:Proliferating Cell Nuclear Antigen