title: Increased serum concentration of soluble CD30 in patients with Graves' disease and Hashimoto's thyroiditis.
abstract: This study investigated serum levels of the soluble form of CD30 (sCD30), which is mainly secreted from T helper 2(Th2) cells, in autoimmune thyroid diseases. The possible relationship of sCD30 to autoantibody production was also evaluated. Serum levels of sCD30 were determined by an enzyme-linked immunosorbent assay in 71 patients with Graves' disease, 37 patients with Hashimoto's thyroiditis, and 21 normal donors. Compared with normal subjects (7.1 +/- 4.5 U/mL), sCD30 was increased in patients with Graves' disease (29.2 +/- 25.2 U/mL, P < 0.0001) and in patients with Hashimoto's thyroiditis (29.9 +/- 26.9 U/mL, P < 0.0001). In Graves' disease, sCD30 levels were higher in thyrotoxic patients (41.7 +/- 31.2 U/mL, P < 0.001) than in remission patients (15.8 +/- 11.0 U/mL), and a significant correlation was observed between sCD30 levels and serum activities of TSH receptor antibody (r = 0.444, P < 0.0001). In Hashimoto's thyroiditis, sCD30 levels were higher in patients with transient destructive thyrotoxicosis caused by the aggravation of the disease (48.8 +/- 34.4 U/mL, P < 0.05) than in euthyroid patients (24.2 +/- 19.4 U/mL). These data suggest that serum sCD30 is a valuable marker of disease activity and support an important role of the Th2-type immune response in the pathogenesis in Graves' disease and Hashimoto's thyroiditis.
authors.affiliation: Department of Laboratory Medicine, Osaka University Medical School, Suita, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Okumura
authors.forename: Y
authors.initials: Y
authors.lastname: Hidaka
authors.forename: S
authors.initials: S
authors.lastname: Kuroda
authors.forename: K
authors.initials: K
authors.lastname: Takeoka
authors.forename: H
authors.initials: H
authors.lastname: Tada
authors.forename: N
authors.initials: N
authors.lastname: Amino
mesh_terms: D000328:Adult; D001323:Autoantibodies / Q000032:analysis; D005260:Female; D006111:Graves Disease / Q000276:immunology*; D006801:Humans; D017730:Ki-1 Antigen / Q000032:analysis*; D008875:Middle Aged; D012016:Reference Values; D012995:Solubility; D013967:Thyroiditis, Autoimmune / Q000276:immunology*; D013971:Thyrotoxicosis / Q000276:immunology
chemical_list: D001323:Autoantibodies; D017730:Ki-1 Antigen