title: Malignant melanoma of the lacrimal sac complicating primary acquired melanosis of the conjunctiva.
abstract: An 81-year-old woman with primary acquired melanosis of the conjunctiva had multinodular invasive malignant melanoma, with one nodule engulfing the superior lacrimal punctum. At exenteration, the lacrimal sac was noted to be involved with melanoma, and an en bloc resection of the orbital contents along with the medial orbital wall and the medial wall of the maxillary antrum was performed to excise the lacrimal drainage apparatus. In situ melanoma was found in the superior canaliculus with invasive melanoma in the lacrimal sac. In situ melanoma was also found in the ductules of the lacrimal gland and the accessory lacrimal glands of the fornix. The patient died 8 months later of metastatic melanoma. The involvement of the lacrimal drainage apparatus by primary acquired melanosis or in situ melanoma makes clinical monitoring and management difficult.
authors.affiliation: Royal Victorian Eye and Ear Hospital, Melbourne, Australia.
authors.forename: A A
authors.initials: AA
authors.lastname: McNab
authors.forename: P
authors.initials: P
authors.lastname: McKelvie
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003228:Conjunctiva / Q000473:pathology*; D003230:Conjunctival Neoplasms / Q000556:secondary* / Q000601:surgery; D017809:Fatal Outcome; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007765:Lacrimal Apparatus / Q000473:pathology*; D007766:Lacrimal Apparatus Diseases / Q000473:pathology* / Q000601:surgery; D008545:Melanoma / Q000556:secondary* / Q000601:surgery; D008548:Melanosis / Q000209:etiology* / Q000473:pathology; D009361:Neoplasm Invasiveness; D017233:Orbit Evisceration