title: Antimuscle and anti-CNS circulating antibodies in chronic fatigue syndrome.
abstract: Chronic fatigue syndrome (CFS) patients suffer from disabling physical and mental fatigue. Circulating autoimmune antibodies may produce symptoms of muscular fatigue by reacting with acetylcholine receptors or calcium binding channels. They can also produce mental status changes by reacting with central nervous system (CNS) antigens. We thoroughly investigated the presence of circulating antimuscle and anti-CNS antibodies in 10 CFS patients and 10 controls. We were unable to detect any pathogenic antibodies.
authors.affiliation: Chronic Fatigue Syndrome Center, Mercy Hospital, Chicago, IL, USA.
authors.forename: A V
authors.initials: AV
authors.lastname: Plioplys
mesh_terms: D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000097:blood*; D002490:Central Nervous System / Q000276:immunology*; D015673:Fatigue Syndrome, Chronic / Q000276:immunology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000276:immunology*; D011795:Surveys and Questionnaires
chemical_list: D001323:Autoantibodies