title: Characteristics of patients with rapidly growing cervical cancer.
abstract: Between April 1983 and December 1990, 387 newly diagnosed cervical cancer cases were managed at our institution. We retrospectively reviewed 59 of those cases, which were identified as having developed within 3 years of the patients' last normal Pap smear. Squamous cell carcinoma was found in 45 patients, and 33 had poorly differentiated lesions. Six cases had typical histology. However, 27 cases (82%) had distinctive histologic features that have not been previously described in rapidly progressive cervical cancer. Thirty-seven patients had surgical treatment; 7 (19%) died of disease. Twenty-two patients had radiation; 10 (45%) died of disease. Patients who have invasive cervical cancer after a recent normal Pap smear may have unusual histologic types, and some with early-stage disease may have better outcome if treated with radical surgery.
authors.affiliation: Department of Obstetrics and Gynecology, Medical College of Georgia, Augusta 30912-3335, USA.
authors.forename: D C
authors.initials: DC
authors.lastname: Gallup
authors.forename: T E
authors.initials: TE
authors.lastname: Nolan
authors.forename: M G
authors.initials: MG
authors.lastname: Hanly
authors.forename: L B
authors.initials: LB
authors.lastname: Otken
authors.forename: D G
authors.initials: DG
authors.lastname: Gallup
authors.forename: R C
authors.initials: RC
authors.lastname: Maier
mesh_terms: D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D002423:Cause of Death; D002466:Cell Nucleolus / Q000648:ultrastructure; D002467:Cell Nucleus / Q000648:ultrastructure; D003131:Combined Modality Therapy; D003593:Cytoplasm / Q000648:ultrastructure; D018450:Disease Progression; D004804:Eosinophils / Q000473:pathology; D004848:Epithelium / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007044:Hysterectomy; D008197:Lymph Node Excision; D009361:Neoplasm Invasiveness; D009504:Neutrophils / Q000473:pathology; D065006:Papanicolaou Test; D017584:Reproductive History; D012189:Retrospective Studies; D015996:Survival Rate; D016896:Treatment Outcome; D002583:Uterine Cervical Neoplasms / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D014626:Vaginal Smears