The effects of bupropion in vivo in the neostriatum of 5-day-old and adult rats.
Infusion of six concentrations of the dopamine uptake inhibitor bupropion into the neostriatum increased extracellular dopamine in a dose-dependent manner in 5-day-old and adult rats. There was no age-related difference when calculated as a percentage of predrug dopamine baseline levels, but the absolute increase of dopamine was greater in the adult rats. Bupropion had only a minor effect on extracellular levels of DOPAC.
Gazzara
R A
RA
Department of Psychology, Binghamton University, NY 13902-6000, USA. rgazzara@nctr.fda.gov
Andersen
S L
SL
D000375:Aging / Q000378:metabolism*; D000818:Animals; D000831:Animals, Newborn; D016642:Bupropion / Q000494:pharmacology*; D004298:Dopamine / Q000378:metabolism*; D018765:Dopamine Uptake Inhibitors / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D008297:Male; D017551:Microdialysis; D017072:Neostriatum / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley
D018765:Dopamine Uptake Inhibitors; D016642:Bupropion; D004298:Dopamine