title: Persistent low back pain in patients suspected of having herniated nucleus pulposus: radiologic predictors of functional outcome--implications for treatment selection.
abstract: OBJECTIVE
  To assess the relationship between imaging findings, therapy, and functional outcome in patients with persistent low back pain who are suspected of having herniated nucleus pulposus.
  
  
  METHODS
  Data collected during a multicenter, longitudinal study were retrospectively analyzed (n = 1,084). Multivariate regression was used to determine the association between imaging findings, therapy, and functional outcome. The patient outcome measure was disability days: the number of days the patient was unable to perform work-related activities.
  
  
  RESULTS
  In patients with at least one normal advanced (imaging other than plain radiography) diagnostic study or with an unconfirmed diagnosis of herniated nucleus pulposus, outcome at 2-year follow-up was no better in patients who were treated than in those who were not. In patients with only abnormal advanced imaging results or with a concordant diagnosis based on clinical and imaging findings, outcome was better in patients who underwent surgery than in those treated nonsurgically. Patients with a free fragment, protrusion, or extrusion that was treated surgically had fewer disability days than patients treated nonsurgically.
  
  
  CONCLUSIONS
  Advanced diagnostic imaging studies can play an important role in treatment selection in patients with persistent low back pain who are suspected of having herniated nucleus pulposus.
authors.affiliation: Russel H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins Medical Institutions, Baltimore, Md, USA.
authors.forename: S J
authors.initials: SJ
authors.lastname: Ackerman
authors.forename: E P
authors.initials: EP
authors.lastname: Steinberg
authors.forename: R N
authors.initials: RN
authors.lastname: Bryan
authors.forename: M
authors.initials: M
authors.lastname: BenDebba
authors.forename: D M
authors.initials: DM
authors.lastname: Long
mesh_terms: D000041:Absenteeism; D000328:Adult; D000368:Aged; D015360:Analgesia, Epidural; D015986:Confounding Factors, Epidemiologic; D003952:Diagnostic Imaging; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007404:Intervertebral Disc Chemolysis; D007405:Intervertebral Disc Displacement / Q000150:complications* / Q000175:diagnosis / Q000601:surgery / Q000628:therapy; D016014:Linear Models; D008137:Longitudinal Studies; D017116:Low Back Pain / Q000209:etiology*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009192:Myelography; D010347:Patient Care Planning; D026741:Physical Therapy Modalities; D012044:Regression Analysis; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome