title: An initial assessment of the genotoxic impact of the Sea Empress oil spill by the measurement of DNA adduct levels in the intertidal teleost Lipophrys pholis.
abstract: The Sea Empress oil spill resulted in the release of vast quantities of potentially genotoxic contaminants into the coastal environment of the county of Pembrokeshire (UK). We are at present attempting to determine the potential genotoxic impact of the incident upon the native marine species of the area. Here we describe the levels of DNA adducts in specimens of the intertidal teleost, Lipophrys pholis, exposed to extensive oil extensive oil contamination as an indication of exposure to potential genotoxins. We detected elevated levels of adducts in L. pholis specimens from an area that underwent heavy oil contamination as compared to specimens from a clean reference area devoid of oil contamination. These preliminary studies indicated that the oil contamination induced DNA adducts in the L. pholis specimens, which could potentially cause genetic damage in this native marine species. Further studies are now required to assess the full extent of the genotoxic impact of the oil spill upon the Pembrokeshire area's native marine life.
authors.affiliation: Centre for Molecular Genetics and Toxicology, School of Biological Sciences, University of Wales Swansea, UK.
authors.forename: B P
authors.initials: BP
authors.lastname: Lyons
authors.forename: J S
authors.initials: JS
authors.lastname: Harvey
authors.forename: J M
authors.initials: JM
authors.lastname: Parry
mesh_terms: D000818:Animals; D015415:Biomarkers; D004247:DNA / Q000737:chemistry / Q000302:isolation & purification; D018736:DNA Adducts / Q000032:analysis*; D005399:Fishes / Q000235:genetics*; D005880:Gills / Q000737:chemistry; D007553:Isotope Labeling; D008099:Liver / Q000737:chemistry; D009152:Mutagenicity Tests; D009153:Mutagens / Q000633:toxicity*; D010578:Petroleum; D010761:Phosphorus Radioisotopes; D014874:Water Pollutants, Chemical / Q000633:toxicity*
chemical_list: D015415:Biomarkers; D018736:DNA Adducts; D009153:Mutagens; D010578:Petroleum; D010761:Phosphorus Radioisotopes; D014874:Water Pollutants, Chemical; D004247:DNA