title: The effects of glucose or lipid infused intravenously or intragastrically on voluntary food intake in the rat.
abstract: Glucose or lipid was infused intravenously (IV) or intragastrically (IG) 30 min before and also during the 17 h when rats were fed both a high-carbohydrate diet and a high-fat diet. Three-day infusions of 28.1 kcal of glucose reduced daily food intake by 19.7 +/- 1.9 kcal/day, representing an oral intake reduction equivalent to 70% of each calorie infused. Infusions of 28.1 kcal of lipid reduced baseline food intake by 11.2 +/- 2.7 kcal/day or 40% of each calorie infused (p < 0.0005). Furthermore, infusions of nutrient IG reduced baseline food intake by 17.6 +/- 2.1 kcal/day or 63% of each calorie infused, and infusions of nutrient IV reduced baseline food intake by 13.7 +/- 2.6 kcal/day or 49% of each calorie infused (p < 0.05). Also, glucose infusions (1.0 kcal/40 min) reduced 10-min food intake from saline baseline levels by 1.1 +/- 0.5 kcal, but lipid infusions had no effect. Infused glucose is more effective than lipid in inhibiting short-term intake, daily food intake, and intake of high-carbohydrate diet, and IG infusion is more effective than IV infusion in inhibiting daily food intake.
authors.affiliation: Department of Medical Physiology, Health Sciences Center, University of Calgary, Alberta, Canada. burggraf@acs.ucalgary.ca
authors.forename: K K
authors.initials: KK
authors.lastname: Burggraf
authors.forename: A E
authors.initials: AE
authors.lastname: Willing
authors.forename: H S
authors.initials: HS
authors.lastname: Koopmans
mesh_terms: D000818:Animals; D004435:Eating / Q000187:drug effects*; D005947:Glucose / Q000008:administration & dosage / Q000494:pharmacology*; D007275:Injections, Intravenous; D008055:Lipids / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011917:Rats, Inbred Lew
chemical_list: D008055:Lipids; D005947:Glucose