title: Camguk, Lin-2, and CASK: novel membrane-associated guanylate kinase homologs that also contain CaM kinase domains.
abstract: MAGUKs (membrane-associated guanylate kinase homologs) are proteins involved in cell junction organization, tumor suppression, and signalling. Their structure includes one or three copies of a DHR or PDZ domain (discs-large homologous region or PSD-95/SAP90, discs-large ZO-1 homologous domain), an SH3 domain, and a guanylate kinase domain. MAGUKs were classified into two subfamilies: Dlg-like with three DHR/PDZ domains and p55-like with a single DHR/PDZ domain. There is now a new subfamily whose members have a novel domain structure: a calcium/calmodulin-dependent protein kinase domain in the N-terminus as well as the DHR/PDZ, SH3 and GUK domains in the C-terminus. These new MAGUKs may regulate transmembrane molecules that bind calcium, calmodulin, or nucleotides, camguk (cmg) is a Drosophila member of this novel MAGUK subfamily; we report its sequence and domain structure.
authors.affiliation: University of California at Irvine, Department of Developmental and Cell Biology 92697, USA. sdimitra@gandalf.bio.uci.edu
authors.forename: S D
authors.initials: SD
authors.lastname: Dimitratos
authors.forename: D F
authors.initials: DF
authors.lastname: Woods
authors.forename: P J
authors.initials: PJ
authors.lastname: Bryant
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D017173:Caenorhabditis elegans / Q000378:metabolism; D017871:Calcium-Calmodulin-Dependent Protein Kinases / Q000737:chemistry*; D004330:Drosophila / Q000378:metabolism; D029721:Drosophila Proteins; D051528:Guanylate Kinases; D015801:Helminth Proteins / Q000096:biosynthesis / Q000737:chemistry*; D006801:Humans; D008565:Membrane Proteins / Q000096:biosynthesis / Q000737:chemistry*; D008969:Molecular Sequence Data; D009703:Nucleoside-Phosphate Kinase / Q000096:biosynthesis / Q000737:chemistry*; D051381:Rats; D017386:Sequence Homology, Amino Acid; D015398:Signal Transduction
chemical_list: D029721:Drosophila Proteins; D015801:Helminth Proteins; C097978:Lin-2 protein, C elegans; D008565:Membrane Proteins; C106868:CASK kinases; C099190:CASK protein, Drosophila; D017871:Calcium-Calmodulin-Dependent Protein Kinases; D009703:Nucleoside-Phosphate Kinase; D051528:Guanylate Kinases