A flexible magnetization transfer line shape derived from tissue experimental data.
To summarize and compare magnetization transfer data from biological tissues, a method was developed to extract the average absorption lineshape of the semi-solid pool directly from magnetization transfer experimental data along with the four other parameters that characterize the two-pool model of exchange. Magnetization transfer data for several biological tissues were analyzed using this method and the resulting "flexible" lineshapes were compared with super-Lorentzian and "Kubo-Tomita" lineshapes. The use of flexible lineshapes noticeably improves the fit of the two-pool model to the data. The derived flexible lineshapes of all the tissues analyzed are physically realistic and show remarkably consistent behavior.
Li
J G
JG
Sunnybrook Health Science Center, Department of Medical Biophysics, Toronto, Ontario, Canada.
Graham
S J
SJ
Henkelman
R M
RM
D000818:Animals; D001921:Brain; D002417:Cattle; D066298:In Vitro Techniques; D008099:Liver; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008954:Models, Biological; D008970:Molecular Weight; D018482:Muscle, Skeletal; D009900:Optic Nerve