Cardiac function in a rat model of chronic aortic stiffness.
Cardiac function was investigated in conscious normotensive rats in which increased aortic stiffness was produced as a result of vascular calcium overload after treatment with vitamin D3 plus nicotine (VDN rats, n = 16; controls, n = 17). Baseline stroke volume, cardiac output, and cardiac response to a venous volume overload were unchanged after 1 mo of exposure to increased aortic stiffness, as were baseline venous return and total vascular capacitance. The latter was estimated from the change in mean circulatory filling pressure after modification of circulatory volume. Cardiovascular reflexes were modified in VDN rats. Bradycardia evoked by an increase in arterial PCO2 (PaCO2) or hypotensive hemorrhage was more pronounced. The PaCO2-induced bradycardia was accompanied by a fall in cardiac output in VDN rats but not in controls. In VDN rats, the attenuation of sympathetic reflexes may explain the slower recovery of blood pressure after hypotensive hemorrhage. In conclusion, a chronic increase in aortic stiffness does not compromise cardiac performance, but cardiovascular reflexes are impaired in VDN rats. Whether this is because of the increase in aortic stiffness or the effect of VDN treatment on the baroreceptors or other components of the reflex arc remains to be elucidated.
Lartaud-Idjouadiene
I
I
Laboratoire de Pharmacologie Cardio-vasculaire, Faculté de Pharmacie, Université Henri Poincaré-Nancy I, France.
Niederhoffer
N
N
Debets
J J
JJ
Struyker-Boudier
H A
HA
Atkinson
J
J
Smits
J F
JF
D000818:Animals; D001011:Aorta / Q000503:physiopathology*; D001810:Blood Volume; D001835:Body Weight; D002118:Calcium / Q000378:metabolism; D002245:Carbon Dioxide / Q000097:blood; D002302:Cardiac Output; D002762:Cholecalciferol / Q000494:pharmacology; D004548:Elasticity; D006352:Heart Ventricles / Q000033:anatomy & histology; D006439:Hemodynamics; D006470:Hemorrhage / Q000503:physiopathology; D009538:Nicotine / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar
D002245:Carbon Dioxide; D002762:Cholecalciferol; D009538:Nicotine; D002118:Calcium