Autonomic nervous system imbalance and left ventricular systolic dysfunction as potential candidates for arrhythmogenesis in Becker muscular dystrophy.
We evaluated the arrhythmic profile in a population of 20 Becker muscular dystrophy (BMD) patients searching for possible correlations between the severity of the arrhythmic events, the cardiac autonomic balance (assessed by heart rate variability analysis in the time domain) and the degree of left ventricular systolic impairment. A population of 14 male healthy individuals served as the control group. BMD subjects exhibited lower values of SDNN (P=0.013), SDANN index (P=0.008) and 24-h mean heart rate (P=0.002). The total number of premature ventricular beats (totPVB) and the number of PVB out of 1000 heartbeats (PVB/1000) appeared also higher in BMD subjects (P=0.05 and P=0.046, respectively). No difference was found in terms of 24-h mean QTc and 24-h longest QT among the two groups. TotPVB and PVB/1000 were inversely related to both the ejection fraction (r= -0.620, P=0.004 and r= -0.517, P=0.019) and to the shortening fraction (r= -0.568, P=0.009 and r= -0.469, P=0.037). Twenty-four-h mean QTc was also inversely related to both the ejection fraction (r= -0.520, P=0.019) and the fractional shortening (r= -0.491, P=0.028). These data suggest that in BMD there is cardiac autonomic imbalance characterized by sympathetic predominance and an increased susceptibility to ventricular arrhythmias, even in the absence of overt cardiomyopathy. Furthermore, the severity of the arrhythmic profile in BMD appears closely related to the degree of left ventricular systolic dysfunction.
Ducceschi
V
V
Istituto Medico Chirurgico di Cardiologia, Cattedra di Cardiologia, Seconda Universita' di Napoli, Naples, Italy.
Nigro
G
G
Sarubbi
B
B
Comi
L I
LI
Politano
L
L
Petretta
V R
VR
Nardi
S
S
Briglia
N
N
Santangelo
L
L
Nigro
G
G
Iacono
A
A
D000328:Adult; D001341:Autonomic Nervous System / Q000503:physiopathology*; D004247:DNA / Q000032:analysis; D016189:Dystrophin / Q000235:genetics; D004452:Echocardiography; D015716:Electrocardiography, Ambulatory; D006339:Heart Rate; D006352:Heart Ventricles / Q000294:innervation* / Q000503:physiopathology; D006801:Humans; D008297:Male; D009136:Muscular Dystrophies / Q000150:complications* / Q000175:diagnosis / Q000378:metabolism; D016133:Polymerase Chain Reaction; D011379:Prognosis; D011446:Prospective Studies; D013318:Stroke Volume; D013599:Systole; D017180:Tachycardia, Ventricular / Q000150:complications* / Q000000981:diagnostic imaging / Q000503:physiopathology; D014630:Vagus Nerve / Q000503:physiopathology; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging / Q000209:etiology* / Q000503:physiopathology
D016189:Dystrophin; D004247:DNA