title: Antifungal pharmacodynamic characteristics of fluconazole and amphotericin B tested against Candida albicans.
abstract: Time-kill curves were determined for three isolates of Candida albicans tested against fluconazole and amphotericin B at multiples of the MIC. Fluconazole produced fungistatic activity, with concentration-related growth effects observed over a narrow range of concentrations. Amphotericin B exhibited fungicidal activity, with enhancement of activity over a broader range of concentrations.
authors.affiliation: College of Pharmacy, University of Iowa, Iowa City 52242-1112, USA. michael-klepser@uiowa.edu
authors.forename: M E
authors.initials: ME
authors.lastname: Klepser
authors.forename: E J
authors.initials: EJ
authors.lastname: Wolfe
authors.forename: R N
authors.initials: RN
authors.lastname: Jones
authors.forename: C H
authors.initials: CH
authors.lastname: Nightingale
authors.forename: M A
authors.initials: MA
authors.lastname: Pfaller
mesh_terms: D000666:Amphotericin B / Q000493:pharmacokinetics / Q000494:pharmacology*; D000935:Antifungal Agents / Q000493:pharmacokinetics / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects*; D015725:Fluconazole / Q000493:pharmacokinetics / Q000494:pharmacology*; D007700:Kinetics; D008826:Microbial Sensitivity Tests; D013997:Time Factors
chemical_list: D000935:Antifungal Agents; D000666:Amphotericin B; D015725:Fluconazole