Inhibition of human leukocyte proteinase 3 by a novel recombinant serine proteinase inhibitor (LEX032).
The interaction of a bioengineered serpin (LEX032) with human leukocyte proteinase 3 (PR 3) has been investigated. LEX032 was found to be a time-dependent inhibitor of PR 3, forming a highly-stable enzyme-inhibitor complex (Ki 12 nM).
Groutas
W C
WC
Department of Chemistry, Wichita State University, Kansas 67260, USA.
Ruan
S
S
Kuang
R
R
Hook
J B
JB
Sands
H
H
D000595:Amino Acid Sequence; D001665:Binding Sites / Q000235:genetics; D006801:Humans; D066298:In Vitro Techniques; D007700:Kinetics; D007962:Leukocytes / Q000201:enzymology*; D053146:Myeloblastin; D011994:Recombinant Proteins / Q000235:genetics / Q000494:pharmacology; D012697:Serine Endopeptidases / Q000378:metabolism*; D015842:Serine Proteinase Inhibitors / Q000235:genetics / Q000494:pharmacology*; D015843:Serpins / Q000235:genetics / Q000494:pharmacology*
C095800:LEX 032; D011994:Recombinant Proteins; D015842:Serine Proteinase Inhibitors; D015843:Serpins; D012697:Serine Endopeptidases; D053146:Myeloblastin