title: Understanding angioid streaks.
abstract: BACKGROUND
  Angioid streaks are defined as a series of linear, cracked-line dehiscences of Bruch's membrane, with secondary changes in the retinal pigment epithelium and choriocapillaris. They may be progressive or degenerative, with varied presentation, color, distribution, and retinal involvement.
  
  
  METHODS
  The epidemiology, pathophysiology, diagnosis, and management of angioid streaks are described. In addition, the systemic diseases most commonly associated with the disease are reviewed.
  
  
  RESULTS
  Optometrists need to be able to differentially diagnose angioid streaks and to refer for evaluation of underlying systemic disease.
  
  
  CONCLUSIONS
  Angioid streaks are considered a rare disorder, associated with pseudoxanthoma elasticum, Paget's disease of the bone, sickle hemoglobinopathies. Marfan syndrome, and Ehlers-Danlos syndrome. Ocular complications include subretinal choroidal neovascular membrane formation. Clinicians should be aware of the disease's subtle ocular appearance, its association with systemic diseases, its potential for producing subretinal ocular complications, and correct management protocols and treatments.
authors.affiliation: Pennsylvania College of Optometry, Philadelphia 19141, USA.
authors.forename: A S
authors.initials: AS
authors.lastname: Gurwood
authors.forename: D L
authors.initials: DL
authors.lastname: Mastrangelo
mesh_terms: D000793:Angioid Streaks / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D003937:Diagnosis, Differential; D005451:Fluorescein Angiography / Q000379:methods; D005654:Fundus Oculi; D006801:Humans; D012160:Retina / Q000473:pathology*