[The clinical significance of the liver glutathione system in chronic lesions].
It is shown that chronic hepatobiliary pathology is associated with a fall in spontaneous metabolite conjugation related to reduced concentration of hepatic glutathione. There was also enhanced activity of glutathione-dependent enzymes. This indicates progress of compensatory processes associated with mobilization of detoxication phase 2, i.e. stimulation of conjugation processes under depression of cytochrome P-450 system. The authors ascertain high informative value of hepatic glutathione transferase in assessment of disease activity in patients with chronic active hepatitis and hepatic cirrhosis.
Loginov
A S
AS
Matiushin
B N
BN
Tkachev
V D
VD
D001707:Biopsy, Needle; D002908:Chronic Disease; D004796:Clinical Enzyme Tests; D005978:Glutathione / Q000032:analysis / Q000378:metabolism*; D005979:Glutathione Peroxidase / Q000032:analysis; D005980:Glutathione Reductase / Q000032:analysis; D005982:Glutathione Transferase / Q000032:analysis; D006801:Humans; D008099:Liver / Q000737:chemistry / Q000201:enzymology* / Q000473:pathology; D008107:Liver Diseases / Q000175:diagnosis*; D010084:Oxidation-Reduction
D005979:Glutathione Peroxidase; D005980:Glutathione Reductase; D005982:Glutathione Transferase; D005978:Glutathione