Genes for interleukin-2 receptor beta chain, interleukin-1 beta, and schizophrenia: no evidence for the association or linkage.
We studied a CA repeat polymorphism of the interleukin-2 receptor beta chain (IL-2RB) gene and a C/-514/T variation of the interleukin-1 beta (IL-1B) gene in Japanese schizophrenia patients. Both a case-control association study (54 patients and 54 controls) and a linkage study using six multiplex families (the number of the affected > or =4 in each family) were employed. No evidence for the association or the linkage was obtained either for the IL-2RB or IL-1B gene.
Tatsumi
M
M
Department of Psychiatry, Showa University School of Medicine, Tokyo, Japan.
Sasaki
T
T
Sakai
T
T
Kamijima
K
K
Fukuda
R
R
Kunugi
H
H
Hattori
M
M
Nanko
S
S
D000483:Alleles; D016022:Case-Control Studies; D018900:Dinucleotide Repeats; D008040:Genetic Linkage; D005838:Genotype; D006801:Humans; D007375:Interleukin-1 / Q000235:genetics*; D007564:Japan; D008126:Lod Score; D011110:Polymorphism, Genetic; D015375:Receptors, Interleukin-2 / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics*
D007375:Interleukin-1; D015375:Receptors, Interleukin-2