Sch 54445: a new polycyclic xanthone with highly potent antifungal activity produced by Actinoplanes sp.
A novel antifungal agent, Sch 54445, was isolated from the fermentation broth of an Actinoplanes species. Sch 54445 was identified as a polycyclic xanthone related to the albofungin family of compounds on the basis of analyses of spectroscopic data. As a broad-spectrum antifungal agent, Sch 54445 exhibits highly potent activities against various yeasts and dermatophytes with MIC values approximately 0.00038 microgram/mL.
Chu
M
M
Schering-Plough Research Institute, Kenilworth, New Jersey 07003, USA.
Truumees
I
I
Mierzwa
R
R
Terracciano
J
J
Patel
M
M
Loebenberg
D
D
Kaminski
J J
JJ
Das
P
P
Puar
M S
MS
D000192:Actinomycetales / Q000378:metabolism*; D000935:Antifungal Agents / Q000096:biosynthesis / Q000302:isolation & purification / Q000494:pharmacology*; D002240:Carbohydrate Sequence; D005285:Fermentation; D005658:Fungi / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D008969:Molecular Sequence Data; D014966:Xanthenes / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology*
D000935:Antifungal Agents; C106397:Sch 54445; D014966:Xanthenes