Synthesis and biological properties of some 2H-1-benzopyrano[7,8-b][1,4]benzodioxin-2-ones.
The synthesis of 2H-benzopyrano[7,8-b][1,4]tetrahydrobenzodioxin-2-ones and 2H-benzopyrano [7,8-b][1,4]benzodioxin-2-ones is reported. This class of compounds, prepared with the aim of obtaining new monofunctional photosensitizing drug, appears to be ineffective upon UVA irradiation but shows a moderate but significant activity in the dark.
Rodighiero
P
P
Centro di Studio sulla Chimica del Farmaco e dei Prodotti Biologicamente Attivi, CNR, Padova, Italy.
Chilin
A
A
Guiotto
A
A
Marzano
C
C
Baccichetti
F
F
Carlassare
F
F
Bordin
F
F
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001578:Benzopyrans / Q000138:chemical synthesis* / Q000494:pharmacology; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy; D004273:DNA, Neoplasm / Q000096:biosynthesis; D004147:Dioxins / Q000138:chemical synthesis* / Q000494:pharmacology; D006367:HeLa Cells; D006801:Humans; D017319:Photosensitizing Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D013604:T-Phages / Q000187:drug effects; D014407:Tumor Cells, Cultured; D014466:Ultraviolet Rays
D000970:Antineoplastic Agents; D001578:Benzopyrans; D004273:DNA, Neoplasm; D004147:Dioxins; D017319:Photosensitizing Agents