Troglitazone has a scavenging effect on reactive oxygen species.
Troglitazone (CS-045), a newly developed antidiabetic thiazolidinedione that enhances insulin sensitivity, is similar in structure to several antioxidants, including alpha-tocopherol and probucol. The in vitro antioxidant activity of troglitazone has been demonstrated in alloxan-induced hyperlipoperoxidemic and hyperlipidemic mice. In this study, we found that troglitazone had a scavenging effect on reactive oxygen produced by xanthine-xanthine oxidase and generated by stimulated neutrophils and tends to be the radical form. Our results suggest that troglitazone is an antioxidant similar to alpha-tocopherol. However, under the same conditions, pioglitazone, another thiazolidinedione drug, did not have a scavenging effect. The antioxidant action of troglitazone, which is attributable to the similarity of its molecular structure to that of alpha-tocopherol, may be of benefit in preventing diabetic vascular complications, in addition to having hypoglycemic and hypolipidemic effects.
Inoue
I
I
The Fourth Department of Internal Medicine, Saitama Medical School, Iruma, Japan.
Katayama
S
S
Takahashi
K
K
Negishi
K
K
Miyazaki
T
T
Sonoda
M
M
Komoda
T
T
D000975:Antioxidants / Q000494:pharmacology; D002839:Chromans / Q000737:chemistry / Q000494:pharmacology*; D003574:Cytochrome c Group / Q000378:metabolism; D004121:Dimethyl Sulfoxide / Q000494:pharmacology; D004578:Electron Spin Resonance Spectroscopy; D016166:Free Radical Scavengers / Q000494:pharmacology*; D006801:Humans; D006861:Hydrogen Peroxide / Q000494:pharmacology; D007501:Iron / Q000494:pharmacology; D015394:Molecular Structure; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism*; D000077205:Pioglitazone; D017382:Reactive Oxygen Species / Q000378:metabolism*; D013113:Spin Labels; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology; D013844:Thiazoles / Q000737:chemistry / Q000494:pharmacology*; D045162:Thiazolidinediones; D000077288:Troglitazone; D014810:Vitamin E / Q000737:chemistry / Q000494:pharmacology; D019820:Xanthine; D014969:Xanthine Oxidase / Q000378:metabolism; D014970:Xanthines / Q000378:metabolism
D000975:Antioxidants; D002839:Chromans; D003574:Cytochrome c Group; C045076:Fenton's reagent; D016166:Free Radical Scavengers; D017382:Reactive Oxygen Species; D013113:Spin Labels; D013844:Thiazoles; D045162:Thiazolidinediones; D014970:Xanthines; D014810:Vitamin E; D019820:Xanthine; D006861:Hydrogen Peroxide; D007501:Iron; D014969:Xanthine Oxidase; D000077288:Troglitazone; D013755:Tetradecanoylphorbol Acetate; D000077205:Pioglitazone; D004121:Dimethyl Sulfoxide