title: [Initial experience in the diagnosis of thrombophilia due to activated protein C resistance].
abstract: The authors describe the first in Russia cases of thrombophilia caused by factor Va resistance to activated protein C. This abnormality was diagnosed in 6 of 25 patients (24%) with recurrent early thrombosis. The diagnosis was conducted according to a modified method implying the addition of protac (activator of protein C) to normal platelet poor plasma (PPP) free of factor V containing 100% of protein C. Protac dose was adjusted to increase the activated partial thromboplastin time (APTT) 2.4-2.8-fold in mixing PPP of the examinee with plasma containing activated protein C. The indices were estimated indicative of insufficient prolongation of APTT in response to activated protein C. Of 6 patients, 2 had apparent and 4 strong resistance to activated protein C. Treatment policy in this variant of thrombophilia is discussed.
authors.forename: Z S
authors.initials: ZS
authors.lastname: Barkagan
authors.forename: V B
authors.initials: VB
authors.lastname: Gervaziev
authors.forename: L P
authors.initials: LP
authors.lastname: Tsyvkina
authors.forename: A N
authors.initials: AN
authors.lastname: Mamaev
authors.forename: A A
authors.initials: AA
authors.lastname: Karpenko
authors.forename: I Ia
authors.initials: IIa
authors.lastname: Tseĭmak
mesh_terms: D000293:Adolescent; D000328:Adult; D001780:Blood Coagulation Tests / Q000379:methods; D001791:Blood Platelet Disorders / Q000097:blood / Q000175:diagnosis* / Q000209:etiology; D015943:Factor Va / Q000032:analysis; D005260:Female; D005343:Fibrinolytic Agents; D006487:Hemostasis; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins; D008297:Male; D008875:Middle Aged; D010455:Peptides; D011486:Protein C / Q000032:analysis / Q000037:antagonists & inhibitors*; D012008:Recurrence; D013924:Thrombophlebitis / Q000097:blood / Q000175:diagnosis / Q000209:etiology
chemical_list: D005343:Fibrinolytic Agents; D036341:Intercellular Signaling Peptides and Proteins; D010455:Peptides; D011486:Protein C; C049647:snake venom protein C activator; D015943:Factor Va