title: Number of correlates of membrane metabolism and long-term potentiation in rat brain slices.
abstract: Long-term potentiation was elicited in living slices of rat olfactory cortex by stimulation of the lateral olfactory tract. A group of interdependent parameters of membrane metabolism was studied, i.e., the kinetics of 45Ca metabolism, lipid peroxidation, and antioxidant defense; cytochemical measurements were made of Na+, K(+)-ATPase activity in neurons and glial cells; the functional (GTPase) activity of G-proteins was also studied. All parameters were compared with the bioelectrical activity of slices at three time points after tetanization, i.e., 3-5, 15, and 30 min. In most cases, regular phasic changes in metabolic parameters occurred, and their functional significance is discussed.
authors.affiliation: Laboratory of Functional Neurochemistry, I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg.
authors.forename: N A
authors.initials: NA
authors.lastname: Emel'yanov
authors.forename: T S
authors.initials: TS
authors.lastname: Glushchenko
authors.forename: N L
authors.initials: NL
authors.lastname: Izvarina
authors.forename: U M
authors.initials: UM
authors.lastname: Malikov
authors.forename: N S
authors.initials: NS
authors.lastname: Nilova
authors.forename: N E
authors.initials: NE
authors.lastname: Sokolova
authors.forename: A V
authors.initials: AV
authors.lastname: Tokarev
mesh_terms: D000109:Acetylcholine / Q000378:metabolism; D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D001921:Brain / Q000201:enzymology; D001923:Brain Chemistry / Q000502:physiology*; D002118:Calcium / Q000378:metabolism; D004558:Electric Stimulation; D020558:GTP Phosphohydrolases / Q000378:metabolism; D066298:In Vitro Techniques; D007700:Kinetics; D015227:Lipid Peroxidation / Q000502:physiology; D017774:Long-Term Potentiation / Q000502:physiology*; D008566:Membranes / Q000378:metabolism; D009457:Neuroglia / Q000378:metabolism; D009474:Neurons / Q000378:metabolism; D051381:Rats
chemical_list: D000975:Antioxidants; D020558:GTP Phosphohydrolases; D000109:Acetylcholine; D002118:Calcium