title: No association of the Ser/Cys311 DRD2 molecular variant with schizophrenia using a classical case control study and the haplotype relative risk.
abstract: Arinami et al. (1994) reported an association between the Ser311/Cys311 variant of the DRD2 gene and schizophrenia in a Japanese population. We did not find statistically significant differences in the distribution of the allele frequencies between schizophrenics (103) and controls (97) in a case-control sample (chi 2 = 2.07; p = 0.150) or in 64 nuclear families with the haplotype relative risk (HRR) design (chi 2 = 0.13; p = 0.718). Our results seem to exclude a main involvement of this variant of the dopamine D2 receptor gene in the etiopathogenesis of schizophrenia.
authors.affiliation: Istituto Scientifico H. San Raffaele, Department of Neuropsychiatric Science, University of Milan, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Verga
authors.forename: F
authors.initials: F
authors.lastname: Macciardi
authors.forename: S
authors.initials: S
authors.lastname: Pedrini
authors.forename: S
authors.initials: S
authors.lastname: Cohen
authors.forename: E
authors.initials: E
authors.lastname: Smeraldi
mesh_terms: D017668:Age of Onset; D000483:Alleles; D004247:DNA / Q000032:analysis; D005260:Female; D005838:Genotype; D006239:Haplotypes / Q000235:genetics*; D006801:Humans; D008297:Male; D017448:Receptors, Dopamine D2 / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics*
chemical_list: D017448:Receptors, Dopamine D2; D004247:DNA