Transforming growth factor-beta induced by live or ultraviolet-inactivated equid herpes virus type-1 mediates immunosuppression in the horse.
Up to 21 days after exposure to live or ultraviolet-inactivated equid herpesvirus type-1 (EHV-1) autologous serum from ponies caused an immunosuppressive effect if incorporated into T-cell proliferation assays to EHV-1. The suppressive factor in the sera of ponies also inhibited T-cell response to phytohaemagglutinin. Increased levels of circulating activated transforming growth factor-beta 1 (TGF-beta 1) were detected, and the suppressive activity of the serum could be reversed by antibody to TGF-beta 1. In a challenge experiment the ponies which exhibited circulating TGF-beta 1 activity succumbed to infection while the ones with similar magnitudes of T-cell responses, but no TGF-beta 1 activity, were protected. A definition of this immunosuppressive mechanism and its mode of induction must be central to the design of vaccines and to an understanding of the pathogenesis of EHV-1.
Charan
S
S
Department of Pathology & Infectious Diseases, Royal Veterinary College, London, UK.
Palmer
K
K
Chester
P
P
Mire-Sluis
A R
AR
Meager
A
A
Edington
N
N
D000818:Animals; D006566:Herpesviridae Infections / Q000276:immunology* / Q000662:veterinary*; D004861:Herpesvirus 1, Equid / Q000276:immunology* / Q000528:radiation effects; D006734:Horse Diseases / Q000276:immunology*; D006736:Horses; D007108:Immune Tolerance; D007959:Lymphocyte Culture Test, Mixed; D016133:Polymerase Chain Reaction; D016212:Transforming Growth Factor beta / Q000276:immunology*; D014466:Ultraviolet Rays
D016212:Transforming Growth Factor beta