Multifocal plasmacytoma of hand and foot bones.
Simultaneous occurrence of localized plasmacytomas of both hands and feet has not been reported so far. Here we report a 40-year old female patient, who had at presentation pain and deformity. Of hands and feet, with numerous cystic lytic lesions of phalangeal, metacarpal and metatarsal bones, detected by X-rays. The biopsy of the affected bone showed moderately differentiated plasmacytoma of lambda light chain type (lambda-LC). Serum and urine biochemical analysis revealed the existence of lambda LC monoclonal component. The patient was treated by local radiotherapy and subsequent systemic chemotherapy, which consisted of 3 cycles of the M-2 protocol and 7 cycles of melphalan-prednisone. Five years after the diagnosis, the absence of plasmacytoma was confirmed by puncture biopsy of the left hand phalanx. Monoclonal protein in serum and urine was not detected.
Antonijevic
N
N
Institute of Haematology, Clinical Center of Serbia, Belgrade, Yugoslavia.
Radosevic-Radojkovic
N
N
Colovic
M
M
Jovanovic
V
V
Rolovic
Z
Z
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001859:Bone Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000532:radiotherapy; D002330:Carmustine / Q000008:administration & dosage; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000008:administration & dosage; D005260:Female; D005385:Fingers; D005534:Foot Diseases / Q000188:drug therapy / Q000473:pathology* / Q000532:radiotherapy; D006227:Hand Deformities, Acquired / Q000188:drug therapy / Q000473:pathology* / Q000532:radiotherapy; D006801:Humans; D008558:Melphalan / Q000008:administration & dosage; D008663:Metacarpus; D010954:Plasmacytoma / Q000188:drug therapy / Q000473:pathology* / Q000532:radiotherapy; D011241:Prednisone / Q000008:administration & dosage; D014750:Vincristine / Q000008:administration & dosage
D014750:Vincristine; D003520:Cyclophosphamide; D008558:Melphalan; D002330:Carmustine; D011241:Prednisone