Role of fibroblast growth factors in neural trauma.
Following a traumatic insult to the adult mammalian central nervous system (CNS), a complex of molecular and cellular responses ensues. Several peptide growth factors seem implicated in the CNS traumatic response. Furthermore, several of them, like some of the members of the fibroblast growth factor family of polypeptides seem to have a protective role. The purpose of this article is to point toward some basic aspects of FGFs neuroprotective activity against traumatic CNS injuries for the development of novel therapeutic strategies in neural trauma.
Cuevas
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Hospital Ramón y Cajal, Servicio de Histologia, Madrid, Spain.
Giménez-Gallego
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D000328:Adult; D000818:Animals; D001930:Brain Injuries / Q000503:physiopathology*; D005346:Fibroblast Growth Factors / Q000502:physiology*; D006801:Humans; D018696:Neuroprotective Agents / Q000378:metabolism*; D013119:Spinal Cord Injuries / Q000503:physiopathology*; D014947:Wounds and Injuries / Q000503:physiopathology
D018696:Neuroprotective Agents; D005346:Fibroblast Growth Factors