title: Sertoli-Leydig cell tumour in an infertile patient after stimulated ovulation.
abstract: A 36 year-old infertile female developed a stage IV (FIGO) ovarian carcinoma consisting of a poorly differentiated Sertoli-Leydig cell tumour after receiving one course of ovulation induction with follicle stimulating hormone (FSH), human menopausal gonadotrophin (HMG) and human chorionic gonadotrophin (HCG) followed by gonadotrophin-releasing hormone analogue (GnRHa). The patient died of liver metastasis and hepatic failure 4 1/2 months after first diagnosis, despite aggressive treatment consisting of debulking surgery and aggressive adjuvant chemotherapy.
authors.affiliation: Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital, Linkou Medical Center, Taipei, Taiwan, Republic of China.
authors.forename: H H
authors.initials: HH
authors.lastname: Chou
authors.forename: Y M
authors.initials: YM
authors.lastname: Lai
authors.forename: C H
authors.initials: CH
authors.lastname: Lai
authors.forename: S
authors.initials: S
authors.lastname: Hsueh
authors.forename: Y K
authors.initials: YK
authors.lastname: Soong
mesh_terms: D000328:Adult; D006063:Chorionic Gonadotropin / Q000008:administration & dosage / Q000009:adverse effects; D004359:Drug Therapy, Combination; D017809:Fatal Outcome; D005260:Female; D005640:Follicle Stimulating Hormone / Q000008:administration & dosage / Q000009:adverse effects; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D007247:Infertility, Female / Q000628:therapy*; D017093:Liver Failure / Q000209:etiology; D008113:Liver Neoplasms / Q000150:complications / Q000556:secondary*; D008596:Menotropins / Q000008:administration & dosage / Q000009:adverse effects; D010051:Ovarian Neoplasms / Q000175:diagnosis* / Q000473:pathology; D010062:Ovulation Induction / Q000009:adverse effects*; D018310:Sertoli-Leydig Cell Tumor / Q000175:diagnosis* / Q000473:pathology
chemical_list: D006063:Chorionic Gonadotropin; D007987:Gonadotropin-Releasing Hormone; D008596:Menotropins; D005640:Follicle Stimulating Hormone