title: Effects of monensin on the metabolism of periparturient dairy cows.
abstract: The effects of monensin on plasma concentrations and changes in plasma concentrations of energy metabolites and minerals over time were investigated using 24 multiparous Holstein cows. Cows were paired according to farm, predicted date of calving, and body condition score and were randomly allocated to two groups. Treated cows were given a ruminal bolus containing 32 g of monensin at 50 +/- 7 d before predicted calving. Treated cows had lower plasma concentrations of glucose, free fatty acid (FFA), and beta-hydroxybutyrate (BHBA) than did control cows before calving, indicating that monensin influenced energy metabolism. However, no significant differences in plasma concentrations of glucose, FFA, and BHBA were found between groups after calving. Plasma BHBA concentrations increased more before calving in control cows, and plasma FFA and urea concentrations increased significantly before calving in all cows. No significant differences in body weight, plasma concentrations of urea, or whole blood concentrations of glutathione peroxidase were detected between groups before or after calving. Plasma ceruloplasmin activity did not differ between groups before calving, but was significantly higher in treated cows after calving. Plasma concentrations of Ca did not significantly differ between groups before or after calving. Monensin altered both energy and mineral metabolism and has the potential to improve the health and production of dairy cows.
authors.affiliation: Department to Animal Science, University of Sydney, Camden New South Wales, Australia.
authors.forename: K A
authors.initials: KA
authors.lastname: Stephenson
authors.forename: I J
authors.initials: IJ
authors.lastname: Lean
authors.forename: M L
authors.initials: ML
authors.lastname: Hyde
authors.forename: M A
authors.initials: MA
authors.lastname: Curtis
authors.forename: J K
authors.initials: JK
authors.lastname: Garvin
authors.forename: L B
authors.initials: LB
authors.lastname: Lowe
mesh_terms: D020155:3-Hydroxybutyric Acid; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002118:Calcium / Q000097:blood; D002417:Cattle / Q000378:metabolism*; D002570:Ceruloplasmin / Q000378:metabolism; D004734:Energy Metabolism; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood; D006885:Hydroxybutyrates / Q000097:blood; D007476:Ionophores / Q000494:pharmacology*; D008903:Minerals / Q000378:metabolism*; D008985:Monensin / Q000008:administration & dosage / Q000494:pharmacology*; D011247:Pregnancy; D012417:Rumen / Q000187:drug effects; D014508:Urea / Q000097:blood
chemical_list: D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D006885:Hydroxybutyrates; D007476:Ionophores; D008903:Minerals; D014508:Urea; D008985:Monensin; D005979:Glutathione Peroxidase; D002570:Ceruloplasmin; D002118:Calcium; D020155:3-Hydroxybutyric Acid