title: Corneal optical aberrations induced by photorefractive keratectomy.
abstract: BACKGROUND
  Photorefractive keratectomy causes marked alteration to anterior corneal topography, and is likely to induce major changes to the optical aberrations of the eye.
  
  
  METHODS
  Six diopters (D) of myopia correction was attempted on one eye of 50 patients, randomly allocated to one of three different treatments: 5-mm or 6-mm single ablation zone, or a double ablation (multizone; -5.00 D correction over 4.6 mm and -1.00 D over 6 mm). Topographic data was used to estimate corneal aberration coefficients. These were compared for effect of ablation zone, before and 1 year after photorefractive keratectomy. The coefficients were used to derive modulation transfer functions for the anterior corneal surface.
  
  
  RESULTS
  Corneal spherical aberrations and coma-like aberrations both increased significantly following photorefractive keratectomy (p < 0.001). The mean spherical aberration coefficient increased from 0.36 +/- 0.11 before, to 0.91 +/- 0.37 after treatment, while the mean coma-like aberration coefficient changed from 0.28 +/- 0.16 before, to 0.60 +/- 0.31 after treatment. Ablation zone form had a significant effect on spherical aberration (p = 0.030), but not for coma (p = 0.96). The spherical aberration coefficient increased least for the 6-mm ablation (by 0.38 +/- 0.17), compared with the 5-mm ablation (0.69 +/- 0.45) and the multizone (0.62 +/- 0.38). Corneal modulation transfer functions were reduced significantly following the photorefractive procedure. The effect was greatest for large pupil diameters and for spatial frequencies between 2 and 15 cycles per degree.
  
  
  CONCLUSIONS
  Corneal modulation transfer function calculations suggest that a significant loss of visual performance should be anticipated following photorefractive keratectomy, the effect being greatest for large pupil diameters. Results for three ablation zones show that induced aberrations are least for the largest (6 mm) ablation zone.
authors.affiliation: Dept. of Vision Sciences, Glasgow Caledonian University, UK.
authors.forename: K M
authors.initials: KM
authors.lastname: Oliver
authors.forename: R P
authors.initials: RP
authors.lastname: Hemenger
authors.forename: M C
authors.initials: MC
authors.lastname: Corbett
authors.forename: D P
authors.initials: DP
authors.lastname: O'Brart
authors.forename: S
authors.initials: S
authors.lastname: Verma
authors.forename: J
authors.initials: J
authors.lastname: Marshall
authors.forename: A
authors.initials: A
authors.lastname: Tomlinson
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D003315:Cornea / Q000473:pathology* / Q000601:surgery; D005500:Follow-Up Studies; D006801:Humans; D007091:Image Processing, Computer-Assisted; D054018:Lasers, Excimer; D008962:Models, Theoretical; D009216:Myopia / Q000209:etiology* / Q000601:surgery; D018903:Photorefractive Keratectomy / Q000009:adverse effects*; D012029:Refraction, Ocular; D016896:Treatment Outcome