Garsubellin A, a novel polyprenylated phloroglucin derivative, increasing choline acetyltransferase (ChAT) activity in postnatal rat septal neuron cultures.
Garsubellin A (1), a novel polyprenylated phloroglucin derivative, has been isolated from the wood of Garcinia subelliptica and its structure has been elucidated by spectroscopic analyses. Compound 1 could increase the ChAT activity at 10 microM in P10 rat septal neuron cultures.
Fukuyama
Y
Y
Institute of Pharmacognosy, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Japan.
Kuwayama
A
A
Minami
H
H
D000818:Animals; D001921:Brain / Q000166:cytology / Q000187:drug effects / Q000201:enzymology*; D002795:Choline O-Acetyltransferase / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D009474:Neurons / Q000187:drug effects / Q000201:enzymology*; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D013268:Stimulation, Chemical; D013729:Terpenes / Q000302:isolation & purification / Q000494:pharmacology*
D013729:Terpenes; C106690:garsubellin A; D002795:Choline O-Acetyltransferase