A fatal case of amlodipine poisoning.
A fatal case attributed to amlodipine intoxication is presented. The deceased was a 15-year-old girl who allegedly ingested 14 10-mg Istin tablets. Amlodipine concentration in peripheral blood was determined (2.7 mg/L) and was compared with published therapeutic and toxic data for amlodipine and some other dihydropyridine calcium channel-blocking agents. Amlodipine concentrations in liver, blood, and stomach contents were also determined.
Cosbey
S H
SH
Forensic Science Agency of Northern Ireland, Carrickfergus.
Carson
D J
DJ
D000293:Adolescent; D017311:Amlodipine / Q000032:analysis / Q000097:blood / Q000506:poisoning*; D001344:Autopsy; D001794:Blood Pressure / Q000187:drug effects; D002121:Calcium Channel Blockers / Q000032:analysis / Q000097:blood / Q000506:poisoning*; D016887:Cardiopulmonary Resuscitation; D002851:Chromatography, High Pressure Liquid; D062787:Drug Overdose; D017809:Fatal Outcome; D005260:Female; D005766:Gastrointestinal Contents / Q000737:chemistry; D006323:Heart Arrest / Q000139:chemically induced*; D006801:Humans; D007494:Ireland; D007583:Jejunum; D008099:Liver / Q000378:metabolism; D008528:Mefenamic Acid / Q000097:blood; D013405:Suicide
D002121:Calcium Channel Blockers; D017311:Amlodipine; D008528:Mefenamic Acid