Impairment of calcitonin gene-related peptide-induced potentiation of cholinergic sweat secretion in patients with multiple system atrophy.
Loss of sweating is a characteristic feature of multiple system atrophy (MSA) with autonomic failure, and widespread anhidrosis may lead to hyperthermia and collapse in a hot environment. Calcitonin gene-related peptide (CGRP) is present in the periglandular nerves around sweat glands and is a strong stimulant of methacholine (MCH)-mediated cholinergic sweating. The present study evaluated CGRP-related regulation of cholinergic sweating in patients with MSA. CGRP-induced potentiation of MCH-mediated cholinergic sweating was significantly reduced in MSA patients as compared with normal age-matched controls. These results suggest that regulation of sweating is extensively affected in MSA as a consequence of peptidergic dysfunction.
Kumazawa
K
K
Fourth Department of Internal Medicine, Aichi Medical University, Japan.
Sobue
G
G
Mitsuma
T
T
Sugenoya
J
J
Ogawa
T
T
D001342:Autonomic Nervous System Diseases / Q000378:metabolism* / Q000503:physiopathology; D015740:Calcitonin Gene-Related Peptide / Q000494:pharmacology*; D002526:Cerebellar Diseases / Q000378:metabolism* / Q000503:physiopathology; D004338:Drug Combinations; D005260:Female; D006801:Humans; D007024:Hypotension, Orthostatic / Q000503:physiopathology; D008297:Male; D016210:Methacholine Chloride / Q000494:pharmacology; D008875:Middle Aged; D010275:Parasympathetic Nervous System / Q000187:drug effects* / Q000503:physiopathology*; D010277:Parasympathomimetics / Q000494:pharmacology; D010300:Parkinson Disease / Q000378:metabolism* / Q000503:physiopathology; D013542:Sweat / Q000187:drug effects* / Q000378:metabolism*
D004338:Drug Combinations; D010277:Parasympathomimetics; D016210:Methacholine Chloride; D015740:Calcitonin Gene-Related Peptide