title: Renal parenchymal malakoplakia in a four-week-old infant.
abstract: We describe a four-week-old male infant with bilateral renal parenchymal malakoplakia who presented with low grade fever, convulsions and lethargy. The patient had profound anemia, hepatosplenomegaly and bilateral nephromegaly with reduced renal function. Both blood and urine cultures grew Escherichia coli, and antibiotic therapy was started. A kidney biopsy obtained on the 20th hospital day confirmed the diagnosis of renal parenchymal malakoplakia. Following treatment with an intravenous methylprednisolone pulse therapy, the infant made significant clinical improvement. He has grown and developed normally in the three years following this episode. We suggest that the steroid therapy was useful in ameliorating renal parenchymal malakoplakia in a patient without an underlying systemic disease. This report describes the youngest patient to have malakoplakia.
authors.affiliation: Department of Pediatric, Saga Medical School, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Honjo
authors.forename: T
authors.initials: T
authors.lastname: Sato
authors.forename: M
authors.initials: M
authors.lastname: Matsuo
authors.forename: S
authors.initials: S
authors.lastname: Miyazaki
authors.forename: Y
authors.initials: Y
authors.lastname: Tomiyoshi
mesh_terms: D000892:Anti-Infective Agents, Urinary / Q000008:administration & dosage; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D004334:Drug Administration Schedule; D006801:Humans; D007223:Infant; D007674:Kidney Diseases / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology; D008287:Malacoplakia / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage*; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000008:administration & dosage
chemical_list: D000892:Anti-Infective Agents, Urinary; D000893:Anti-Inflammatory Agents; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D008775:Methylprednisolone