title: Pterulinic acid and pterulone, two novel inhibitors of NADH:ubiquinone oxidoreductase (complex I) produced by a Pterula species. I. Production, isolation and biological activities.
abstract: Pterulinic acid (1) and pterulone (2), two novel halogenated antibiotics, were isolated from fermentations of Pterula sp. 82168. Both compounds exhibited significant antifungal and weak or no cytotoxic activities. 1 and 2 are effective inhibitors of eucaryotic respiration. The target of the antibiotics resides within the mitochondrial NADH:ubiquinone oxidoreductase (complex I).
authors.affiliation: LB Biotechnologie der Universität, Kaiserslautern, FRG.
authors.forename: M
authors.initials: M
authors.lastname: Engler
authors.forename: T
authors.initials: T
authors.lastname: Anke
authors.forename: O
authors.initials: O
authors.lastname: Sterner
authors.forename: U
authors.initials: U
authors.lastname: Brandt
mesh_terms: D000085:Acetates / Q000302:isolation & purification* / Q000494:pharmacology*; D000818:Animals; D000935:Antifungal Agents / Q000302:isolation & purification* / Q000494:pharmacology*; D001572:Benzofurans / Q000302:isolation & purification* / Q000494:pharmacology*; D002417:Cattle; D002851:Chromatography, High Pressure Liquid; D042967:Electron Transport Complex I; D005285:Fermentation; D008826:Microbial Sensitivity Tests; D008928:Mitochondria / Q000187:drug effects; D009247:NADH, NADPH Oxidoreductases / Q000037:antagonists & inhibitors*; D010082:Oxepins; D010101:Oxygen Consumption; D013237:Stereoisomerism; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D000085:Acetates; D000935:Antifungal Agents; D001572:Benzofurans; D010082:Oxepins; C106751:pterulinic acid; C106752:pterulone; D009247:NADH, NADPH Oxidoreductases; D042967:Electron Transport Complex I