A chromosome 18 genetic linkage study in three large Belgian pedigrees with bipolar disorder.
The contribution of genetic factors to the susceptibility for affective disorders has been firmly established. Recent reports found evidence for a susceptibility locus for affective disorders in 2 regions on chromosome 18. We describe 3 large Belgian pedigrees with multiple patients with affective disorders. Both chromosome 18 regions were investigated in the 3 families, using parametric and nonparametric segregation methods. In the pericentromeric region, all evidence was against a disease gene in our families. Also the data obtained for the distal part of 18q, argue against a genetic susceptibility factor in our sample.
Claes
S
S
Center for Human Genetics, University of Leuven, Belgium.
Raeymaekers
P
P
Van den Broeck
M
M
Diependaele
S
S
De bruyn
A
A
Verheyen
G
G
Wils
V
V
Boogaerts
A
A
Tanghe
A
A
Godderis
J
J
Van Broeckhoven
C
C
Cassiman
J J
JJ
D001530:Belgium; D001714:Bipolar Disorder / Q000235:genetics* / Q000523:psychology*; D002887:Chromosomes, Human, Pair 18; D008040:Genetic Linkage; D005838:Genotype; D006239:Haplotypes; D006579:Heterozygote; D006801:Humans; D010375:Pedigree; D016133:Polymerase Chain Reaction