title: Multi-center sestamibi parathyroid imaging study in Hawaii.
abstract: Technetium-99m (99mTc) sestamibi (MIBI) was first used as a parathyroid imaging agent in Hawaii in 1991. The purpose of this study was to determine the sensitivity and positive predictive value of the MIBI scan in detecting abnormal parathyroid glands. A retrospective, multi-center study from 1992-1994 involving 33 patients in four hospitals showed the overall sensitivity of the MIBI scan for detecting hyperparathyroid disease was 90%. The positive predictive value was 93%. It was more sensitive in detecting adenomas (95%) than hyperplasia (45%). In conclusion, the MIBI scan can be helpful in detecting abnormal parathyroid glands and may be most useful prior to reoperations for persistent and recurrent hyperparathyroidism.
authors.affiliation: Department of Surgery, John A. Burns School of Medicine, University of Hawaii, Honolulu, USA.
authors.forename: A H
authors.initials: AH
authors.lastname: Cheung
authors.forename: M S
authors.initials: MS
authors.lastname: Wheeler
authors.forename: L D
authors.initials: LD
authors.lastname: Madanay
authors.forename: E
authors.initials: E
authors.lastname: Hew
authors.forename: M N
authors.initials: MN
authors.lastname: Coel
authors.forename: L M
authors.initials: LM
authors.lastname: Wong
mesh_terms: D000236:Adenoma / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D006965:Hyperplasia / Q000000981:diagnostic imaging / Q000473:pathology; D006980:Hyperthyroidism / Q000000981:diagnostic imaging; D010279:Parathyroid Diseases / Q000000981:diagnostic imaging*; D010280:Parathyroid Glands / Q000000981:diagnostic imaging*; D010282:Parathyroid Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology; D011237:Predictive Value of Tests; D011877:Radionuclide Imaging; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D017256:Technetium Tc 99m Sestamibi
chemical_list: D017256:Technetium Tc 99m Sestamibi