Linkage study of chromosome 6p in sib-pairs with schizophrenia.
Following reports of linkage between schizophrenia and markers in the chromosomal region 6p24-22 we have studied nine microsatellite markers spanning 40 cM of this region in our sample of 102 affected sibling pairs from 86 families. Allele sharing identity by descent was examined using likelihood based sib-pair analysis as implemented by the program SPLINK. No evidence for linkage was obtained and the highest lod score was only 0.192 for D6S309. We conclude that if there is a susceptibility locus for schizophrenia in this region then its effect size is so small as to render our study insufficiently powerful to detect it.
Daniels
J K
JK
Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, United Kingdom.
Spurlock
G
G
Williams
N M
NM
Cardno
A G
AG
Jones
L A
LA
Murphy
K C
KC
Asherson
P
P
Holmans
P
P
Fenton
I
I
McGuffin
P
P
Owen
M J
MJ
D000328:Adult; D000483:Alleles; D002896:Chromosomes, Human, Pair 6 / Q000235:genetics*; D004198:Disease Susceptibility; D005260:Female; D008040:Genetic Linkage; D005838:Genotype; D006801:Humans; D008126:Lod Score; D008297:Male; D018895:Microsatellite Repeats / Q000235:genetics; D009679:Nuclear Family; D012559:Schizophrenia / Q000235:genetics*; D012984:Software; D013223:Statistics as Topic; D018709:Statistics, Nonparametric; D006113:United Kingdom