title: [Impairment of antiviral cellular resistance and possibilities of its correction during acute altitude hypoxia].
abstract: Antiviral cell resistance of blood monocytes and lymphocytes was studied in 29 healthy human subjects subjected to acute altitude hypoxia (AAH) in climatic chamber TABAI, and 39 healthy males during rapid ascent from the sea level up to 3250 m. The antiviral resistance of immune cells was found to be suppressed by AAH. Double blind method was used to compare effects of placebo, dexamethasone and olifen (approved by the Pharmacology Committee of the Russian Ministry of Health as an antihypoxic preparation) on the antiviral resistance of cells during AAH. Unlike dexamethasone, from the onset of AAH olifen prevented decline of the antiviral resistance of cells; olifen successfully remedied disorders resulted from stay in AAH.
authors.forename: D O
authors.initials: DO
authors.lastname: Sinopal'nikov
authors.forename: V I
authors.initials: VI
authors.lastname: Mazurov
authors.forename: S F
authors.initials: SF
authors.lastname: Enokhin
authors.forename: L V
authors.initials: LV
authors.lastname: Filëv
authors.forename: E V
authors.initials: EV
authors.lastname: Volchek
mesh_terms: D000208:Acute Disease; D000328:Adult; D000532:Altitude Sickness / Q000097:blood / Q000188:drug therapy* / Q000276:immunology*; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D000975:Antioxidants / Q000627:therapeutic use*; D003907:Dexamethasone / Q000627:therapeutic use*; D006801:Humans; D007111:Immunity, Cellular; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D009000:Monocytes / Q000276:immunology*; D010647:Phenyl Ethers / Q000627:therapeutic use*; D014780:Viruses / Q000276:immunology*
chemical_list: D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D010647:Phenyl Ethers; C085806:olifen; D003907:Dexamethasone