title: Gliomatosis peritonei with malignant transformation.
abstract: A 13-year-old girl underwent a right salpingo-o-ophorectomy and partial omentectomy for an ovarian tumor that on microscopic examination was a grade 1 immature teratoma. Mature glial implants were found in the omentum (Stage III). No additional treatment was given. Ten months later, grade 0 and grade 1 peritoneal glial implants were found on laparotomy. Chemotherapy with four cycles of vincristine/cisplatin/etoposide/bleomycin was administered. A second laparotomy 4 months later showed persistence of grade 0 and grade 1 peritoneal glial implants. The patient was well for the next 7 years, after which time she presented with a pelvic mass that on microscopic examination was a malignant neuroectodermal tumor resembling a glioblastoma multiforme. The tumor did not respond to debulking and chemotherapy, and the patient died 6 months later, 8 years after her initial presentation. This case represents the second report of malignant transformation of peritoneal glial implants.
authors.affiliation: Department of Pathology and Laboratory Medicine, Vancouver Hospital and Health Sciences Centre, Canada.
authors.forename: F
authors.initials: F
authors.lastname: Dadmanesh
authors.forename: D M
authors.initials: DM
authors.lastname: Miller
authors.forename: K D
authors.initials: KD
authors.lastname: Swenerton
authors.forename: P B
authors.initials: PB
authors.lastname: Clement
mesh_terms: D000293:Adolescent; D002471:Cell Transformation, Neoplastic; D005260:Female; D005910:Glioma / Q000473:pathology* / Q000556:secondary; D006801:Humans; D009457:Neuroglia / Q000473:pathology; D009852:Omentum / Q000473:pathology; D010051:Ovarian Neoplasms / Q000473:pathology*; D010534:Peritoneal Neoplasms / Q000473:pathology* / Q000556:secondary; D013724:Teratoma / Q000473:pathology*