title: Erythema multiforme-like manifestations and arthritis in a 3-year-old child with leukocytoclastic vasculitis.
abstract: A 3-year-old boy with erythema multiforme-like manifestations and severe articular involvement is reported. Because of the unusual onset of the cutaneous lesion a skin biopsy was performed, revealing the typical features of a leukocytoclastic vasculitis. A direct immunofluorescent study revealed C3 and IgM deposition within the wall and around the small vessels. The clinical and immunopathological findings in this patient were similar to those reported for the acute hemorrhagic edema of infancy (AHE) described in children younger than 2 years of age. The present case supports the hypothesis that AHE is a distinctive leukocytoclastic vasculitis of childhood, irrespective of the age at onset.
authors.affiliation: 2nd Division of Pediatrics, G. Gaslini Institute for Children, Genova, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Gattorno
authors.forename: P
authors.initials: P
authors.lastname: Picco
authors.forename: C
authors.initials: C
authors.lastname: Gambini
authors.forename: A
authors.initials: A
authors.lastname: Buoncompagni
authors.forename: E
authors.initials: E
authors.lastname: Castagnola
authors.forename: V
authors.initials: V
authors.lastname: Pistoia
authors.forename: C
authors.initials: C
authors.lastname: Borrone
mesh_terms: D001168:Arthritis / Q000150:complications*; D001808:Blood Vessels / Q000737:chemistry; D002675:Child, Preschool; D003176:Complement C3 / Q000032:analysis; D004892:Erythema Multiforme / Q000150:complications*; D019085:Fluorescent Antibody Technique, Direct; D006801:Humans; D007075:Immunoglobulin M / Q000032:analysis; D008297:Male; D018366:Vasculitis, Leukocytoclastic, Cutaneous / Q000150:complications* / Q000276:immunology / Q000473:pathology
chemical_list: D003176:Complement C3; D007075:Immunoglobulin M