"Cold bone scans" as a sign of hemorrhagic infarcts of the spine in Gaucher's disease.
The most common form of Gaucher's disease, type 1 (chronic non-neuronopathic), results in accumulation of glucocerebroside in reticuloendothelial cells of the spleen, liver and bone marrow, with frequent occurrence of bone pain due to vaso-occlusive crisis. We report the finding of a "cold" vertebral body on bone scan in two patients with Gaucher's disease and bone crisis. Photopenia was so striking as to give the appearance of a "missing" vertebra. Concurrent plain films appeared normal. In one patient Gaucher's disease had not previously been diagnosed.
Dolen
E G
EG
Department of Radiology, Columbia-Presbyterian Medical Center, 177 Fort Washington Avenue, New York, NY 10032, USA.
Berdon
W E
WE
Ruzal-Shapiro
C
C
D000293:Adolescent; D002675:Child, Preschool; D005260:Female; D005776:Gaucher Disease / Q000150:complications / Q000000981:diagnostic imaging*; D006801:Humans; D007238:Infarction / Q000000981:diagnostic imaging* / Q000209:etiology; D008159:Lumbar Vertebrae / Q000098:blood supply* / Q000000981:diagnostic imaging*; D008297:Male; D011877:Radionuclide Imaging; D013122:Spinal Diseases / Q000000981:diagnostic imaging / Q000209:etiology; D013669:Technetium Tc 99m Medronate
D013669:Technetium Tc 99m Medronate