HLA-DR antigens associated with major genetic risk for late-onset Alzheimer's disease.
Hla-dr antigen types were determined from DNA isolated from post-mortem brain tissue of age-matched groups of 78 patients with pathologically confirmed late-onset Alzheimer's disease (AD) and 50 controls. The results suggest that for individuals with no apolipoprotein E epsilon 4 alleles the presence of either DR1, 2 or 3 antigens is associated with a significantly increased risk for development of late-onset AD. Conversely the DR4 or 6 antigens are associated with a decreased risk of similar magnitude. This DR effect, rather than prolonged use of non-steroidal anti-inflammatory drugs, could be responsible for the reported lower prevalence of AD in rheumatoid arthritis (a condition associated with an increased frequency of DR-4).
Curran
M
M
Tissue Typing Laboratory, Belfast City Hospital, UK.
Middleton
D
D
Edwardson
J
J
Perry
R
R
McKeith
I
I
Morris
C
C
Neill
D
D
D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D000544:Alzheimer Disease / Q000235:genetics* / Q000276:immunology; D001057:Apolipoproteins E / Q000235:genetics; D016022:Case-Control Studies; D005260:Female; D006684:HLA-DR Antigens / Q000032:analysis*; D006801:Humans; D008297:Male; D012307:Risk Factors
D001057:Apolipoproteins E; D006684:HLA-DR Antigens