A new animal model for maxillary sinus floor augmentation: evaluation parameters.
This study describes a novel animal model of the maxillary sinus floor augmentation procedure used to assess bone formation during 12 weeks in response to a recombinant human bone morphogenetic protein-2 (rhBMP-2)/absorbable collagen sponge (ACS) sinus implant. A buffer-ACS implant was used as a control. Animal response was monitored using computerized tomography and physical, hematologic, gross pathologic, and histologic evaluations. The rhBMP-2/ACS implants maintained a relatively constant size postsurgery and showed a time-dependent increase in mineralization. The buffer/ACS control implants failed to mineralize and were resorbed by 4 weeks. The model served effectively and without complication. Results indicate rhBMP-2/ACS implants deserve consideration as alternatives to traditional grafting procedures.
Kirker-Head
C A
CA
Orthopedic Research Laboratory, Tufts University, School of Veterinary Medicine, North Grafton, Massachusetts 01536, USA.
Nevins
M
M
Palmer
R
R
Nevins
M L
ML
Schelling
S H
SH
D000042:Absorption; D000818:Animals; D055396:Bone Morphogenetic Protein 2; D019485:Bone Morphogenetic Proteins / Q000627:therapeutic use*; D016025:Bone Transplantation; D002021:Buffers; D002113:Calcification, Physiologic / Q000187:drug effects; D003094:Collagen / Q000627:therapeutic use*; D004195:Disease Models, Animal; D005260:Female; D006041:Goats; D006801:Humans; D008437:Maxilla / Q000000981:diagnostic imaging / Q000187:drug effects / Q000473:pathology / Q000601:surgery; D008443:Maxillary Sinus / Q000000981:diagnostic imaging / Q000187:drug effects / Q000473:pathology / Q000601:surgery*; D010012:Osteogenesis / Q000187:drug effects; D019736:Prostheses and Implants; D011994:Recombinant Proteins; D014057:Tomography, X-Ray Computed; D016212:Transforming Growth Factor beta / Q000627:therapeutic use*
C525718:BMP2 protein, human; D055396:Bone Morphogenetic Protein 2; D019485:Bone Morphogenetic Proteins; D002021:Buffers; D011994:Recombinant Proteins; D016212:Transforming Growth Factor beta; C499469:recombinant human bone morphogenetic protein-2; D003094:Collagen