Genes and the development of vascular disease.
Clinical vascular disease occurs as the result of the chronic development of atherosclerosis, often with acute occlusive thrombus formation as the final event. Both atherosclerotic and thrombotic disorders are complex processes resulting from genetic and environmental interactions. We review genes currently implicated as risk factors and the approaches for identifying novel genetic risk factors.
Foy
C A
CA
Unit of Molecular Vascular Medicine, Leeds General Infirmary, UK.
Grant
P J
PJ
D001161:Arteriosclerosis / Q000235:genetics; D003327:Coronary Disease / Q000235:genetics; D005819:Genetic Markers; D006801:Humans; D015810:Linkage Disequilibrium; D009203:Myocardial Infarction / Q000235:genetics; D007703:Peptidyl-Dipeptidase A / Q000235:genetics; D017395:Plasminogen Activator Inhibitor 1 / Q000235:genetics; D012307:Risk Factors; D014652:Vascular Diseases / Q000235:genetics*
D005819:Genetic Markers; D017395:Plasminogen Activator Inhibitor 1; D007703:Peptidyl-Dipeptidase A