Neuropeptides responding to leptin.
Leptin, the circulating protein that inhibits food intake and energy expenditure, was thought to function through inhibition of the hypothalamic neuropeptide Y (NPY), a stimulator of food intake. However, mouse mutants lacking NPY are normal, suggesting that alternative neuromodulators of food intake must exist. Recently, melanocortin, a neuropeptide acting on the hypothalamic receptor melanocortin4-R, was discovered in mice, controlling energy regulation. This receptor is antagonized by the "agouti" protein in the mutant obese agouti mouse.
Wolf
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Department of Nutritional Sciences, University of California, Berkeley 94720-3104, USA.
D000818:Animals; D006801:Humans; D020738:Leptin; D051379:Mice; D018345:Mice, Knockout; D008820:Mice, Obese; D009478:Neuropeptide Y / Q000502:physiology; D009479:Neuropeptides / Q000502:physiology*; D011506:Proteins / Q000502:physiology*; D018043:Receptors, Corticotropin / Q000502:physiology; D054411:Receptors, Leptin; D044101:Receptors, Melanocortin
C515448:LEPR protein, human; D020738:Leptin; D009478:Neuropeptide Y; D009479:Neuropeptides; D011506:Proteins; D018043:Receptors, Corticotropin; D054411:Receptors, Leptin; D044101:Receptors, Melanocortin; C515447:leptin receptor, mouse