title: Nerve conduction and autonomic nerve function in diabetic children. A 10-year follow-up study.
abstract: In order to study the long-term development of diabetic neuropathy in children with newly diagnosed diabetes mellitus, 144 children were entered in a prospective study of nerve conduction and autonomic nervous function. Neurophysiological recordings of nerve conduction and parasympathetic function (R-R variations) were made at onset of diabetes and after 2, 5 and 10 years. Low sensory nerve conduction and autonomic dysfunction were found in approximately 25% of the children at onset of diabetes when the patients were not yet in complete remission. During years 0-2, an initial improvement of sensory conduction velocities was found. After 2 years, deteriorations in sensory and motor nerve conduction and autonomic nerve function were common and further deterioration was seen over time. A correlation was found between nerve conduction and glycaemic control.
authors.affiliation: Department of Clinical Neurophysiology, Huddinge University Hospital, Sweden.
authors.forename: G
authors.initials: G
authors.lastname: Solders
authors.forename: B
authors.initials: B
authors.lastname: Thalme
authors.forename: M
authors.initials: M
authors.lastname: Aguirre-Aquino
authors.forename: L
authors.initials: L
authors.lastname: Brandt
authors.forename: U
authors.initials: U
authors.lastname: Berg
authors.forename: A
authors.initials: A
authors.lastname: Persson
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003929:Diabetic Neuropathies / Q000503:physiopathology*; D005260:Female; D005500:Follow-Up Studies; D005919:Glomerular Filtration Rate / Q000502:physiology; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D007328:Insulin / Q000008:administration & dosage; D016014:Linear Models; D008297:Male; D008475:Median Nerve / Q000503:physiopathology; D009431:Neural Conduction / Q000502:physiology*; D010275:Parasympathetic Nervous System / Q000503:physiopathology*; D010543:Peroneal Nerve / Q000503:physiopathology; D011446:Prospective Studies; D013497:Sural Nerve / Q000503:physiopathology; D013548:Sweden
chemical_list: D006442:Glycated Hemoglobin; D007328:Insulin