title: A chromosome 18 genetic linkage study in three large Belgian pedigrees with bipolar disorder.
abstract: The contribution of genetic factors to the susceptibility for affective disorders has been firmly established. Recent reports found evidence for a susceptibility locus for affective disorders in 2 regions on chromosome 18. We describe 3 large Belgian pedigrees with multiple patients with affective disorders. Both chromosome 18 regions were investigated in the 3 families, using parametric and nonparametric segregation methods. In the pericentromeric region, all evidence was against a disease gene in our families. Also the data obtained for the distal part of 18q, argue against a genetic susceptibility factor in our sample.
authors.affiliation: Center for Human Genetics, University of Leuven, Belgium.
authors.forename: S
authors.initials: S
authors.lastname: Claes
authors.forename: P
authors.initials: P
authors.lastname: Raeymaekers
authors.forename: M
authors.initials: M
authors.lastname: Van den Broeck
authors.forename: S
authors.initials: S
authors.lastname: Diependaele
authors.forename: A
authors.initials: A
authors.lastname: De bruyn
authors.forename: G
authors.initials: G
authors.lastname: Verheyen
authors.forename: V
authors.initials: V
authors.lastname: Wils
authors.forename: A
authors.initials: A
authors.lastname: Boogaerts
authors.forename: A
authors.initials: A
authors.lastname: Tanghe
authors.forename: J
authors.initials: J
authors.lastname: Godderis
authors.forename: C
authors.initials: C
authors.lastname: Van Broeckhoven
authors.forename: J J
authors.initials: JJ
authors.lastname: Cassiman
mesh_terms: D001530:Belgium; D001714:Bipolar Disorder / Q000235:genetics* / Q000523:psychology*; D002887:Chromosomes, Human, Pair 18; D008040:Genetic Linkage; D005838:Genotype; D006239:Haplotypes; D006579:Heterozygote; D006801:Humans; D010375:Pedigree; D016133:Polymerase Chain Reaction