In-vitro activity of carbapenem antibiotics against beta-lactam susceptible and resistant strains of Burkholderia pseudomallei.
Four carbapenem antibiotics were tested for their in-vitro activities (MICs, MBCs and time-kill studies) against Burkholderia pseudomallei. The carbapenems were all more active than either ceftazidime or co-amoxiclav against strains of B. pseudomallei with a normal susceptibility pattern. Biapenem was the most active antibiotic tested. All four carbapenems retained bactericidal activity against 24 strains of B. pseudomallei with reduced susceptibility to ceftazidime and/or co-amoxiclav.
Smith
M D
MD
Mahidol University, Bangkok, Thailand.
Wuthiekanun
V
V
Walsh
A L
AL
White
N J
NJ
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D016957:Burkholderia pseudomallei / Q000187:drug effects*; D015780:Carbapenems / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D018440:beta-Lactam Resistance
D000900:Anti-Bacterial Agents; D015780:Carbapenems