title: Early and fatal immune haemolysis after so-called 'minor' ABO-incompatible peripheral blood stem cell allotransplantation.
abstract: A 38-year-old man, blood group A+, was allotransplanted for multiple myeloma from his fully matched sister, blood group O+. Anti-A antibodies IgG and IgM titres of the donor were low. Allogeneic peripheral blood stem cells were harvested by leukapheresis after subcutaneous administration of G-CSF. Rapid engraftment occurred since 5.6 x 10(9)/l leukocytes were achieved on day +9 post-transplant. At this time a severe immune haemolytic syndrome occurred and direct antiglobulin test was positive (IgG and C3d). Elution showed an anti-A specificity. Evolution was rapidly unfavourable related to multiorgan failure. The patient died on day +20 post-transplant.
authors.affiliation: Institut Paoli-Calmettes, Bone Marrow Transplant Unit, Marseille, France.
authors.forename: S
authors.initials: S
authors.lastname: Oziel-Taieb
authors.forename: C
authors.initials: C
authors.lastname: Faucher-Barbey
authors.forename: C
authors.initials: C
authors.lastname: Chabannon
authors.forename: P
authors.initials: P
authors.lastname: Ladaique
authors.forename: P
authors.initials: P
authors.lastname: Saux
authors.forename: F
authors.initials: F
authors.lastname: Gouin
authors.forename: J A
authors.initials: JA
authors.lastname: Gastaut
authors.forename: D
authors.initials: D
authors.lastname: Maraninchi
authors.forename: D
authors.initials: D
authors.lastname: Blaise
mesh_terms: D000017:ABO Blood-Group System / Q000276:immunology*; D000328:Adult; D001787:Blood Group Incompatibility / Q000150:complications*; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006461:Hemolysis; D006801:Humans; D008297:Male; D014184:Transplantation, Homologous
chemical_list: D000017:ABO Blood-Group System