The role of leukocyte and endothelial adhesion molecules in ischemia-reperfusion injury.
Reperfusion of ischemic tissue is associated with an acute inflammatory response that may further exacerbate vascular and tissue damage. Compelling evidence from a variety of animal models indicates that neutrophils are the principle effector cells of the reperfusion injury and that blockade of neutrophil adhesion to endothelium attenuates ischemia-reperfusion injury. "Anti-adhesion" therapy may represent a new approach to treatment of the many diverse clinical disorders in which ischemia-reperfusion occurs.
Thiagarajan
R R
RR
Department of Anesthesia & Critical Care, University of Washington, Children's Hospital & Medical Center, Seattle, USA.
Winn
R K
RK
Harlan
J M
JM
D000818:Animals; D015815:Cell Adhesion Molecules / Q000502:physiology*; D004730:Endothelium, Vascular / Q000502:physiology*; D006801:Humans; D007136:Immunoglobulins / Q000502:physiology; D016023:Integrins / Q000502:physiology; D007962:Leukocytes / Q000502:physiology*; D009504:Neutrophils / Q000502:physiology; D015427:Reperfusion Injury / Q000097:blood / Q000503:physiopathology*; D019087:Selectins / Q000502:physiology*
D015815:Cell Adhesion Molecules; D007136:Immunoglobulins; D016023:Integrins; D019087:Selectins