Reduction in the size of a uterine leiomyoma following discontinuation of an estrogen-progestin contraceptive.
The effects of estrogen-progestin oral contraceptives on the volume of uterine leiomyomata is not well characterized. In this case report, a 45-year-old woman with a symptomatic uterine leiomyoma was observed to have a 47% reduction in myoma volume after discontinuation of an oral contraceptive. The volume of uterine leiomyomata may be influenced by oral contraceptives.
Barbieri
R L
RL
Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass. 02115, USA. rlbarbieri@bics.bwh.harvard.edu
D003277:Contraceptives, Oral, Combined / Q000009:adverse effects*; D045166:Estradiol Congeners / Q000009:adverse effects; D004997:Ethinyl Estradiol / Q000009:adverse effects; D005260:Female; D006801:Humans; D007889:Leiomyoma / Q000473:pathology*; D008875:Middle Aged; D009376:Neoplasms, Hormone-Dependent / Q000473:pathology*; D009644:Norgestrel / Q000009:adverse effects; D045167:Progesterone Congeners / Q000009:adverse effects; D012074:Remission Induction; D014594:Uterine Neoplasms / Q000473:pathology*; D014599:Uterus / Q000187:drug effects / Q000473:pathology
D003277:Contraceptives, Oral, Combined; D045166:Estradiol Congeners; D045167:Progesterone Congeners; D009644:Norgestrel; D004997:Ethinyl Estradiol