[Quantitative patterns in the yield of chromosome aberrations in a human lymphocyte culture with fractionated gamma-neutron irradiation at different stages of the mitotic cycle. The cytogenetic effects at stage S].
Quantitative regularities of the chromosome aberrations yield in the human lymphocyte culture affected by fractionated gamma/neutron irradiation (in the direct and inverse sequences) at a stage of the replicative DNA synthesis (S), with the 1 to 5 h intervals between the dose fractions, were studied. The obtained results on the cytogenetic effect of interaction of damages were compared with those for the stages G0 and G1. In contrast to the latter cases, where occurrence of superadditive effects was high, only subadditive effects were observed for the stage S.
Pozdyshkina
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D002478:Cells, Cultured; D002869:Chromosome Aberrations; D004307:Dose-Response Relationship, Radiation; D005214:Fast Neutrons; D005720:Gamma Rays; D006801:Humans; D008214:Lymphocytes / Q000528:radiation effects* / Q000648:ultrastructure; D008938:Mitosis / Q000528:radiation effects*; D016196:S Phase / Q000528:radiation effects*; D013997:Time Factors