title: Systemic infection with Mycobacterium genavense following immunosuppressive therapy in a patient who was seronegative for human immunodeficiency virus.
abstract: We describe, to our knowledge, the first case of disseminated Mycobacterium genavense infection in a patient who was seronegative for human immunodeficiency virus. The patient, a 47-year-old woman, had been previously treated with immunosuppressive drugs for 9 months to control an unclassified immunologic disorder characterized by intermittent fever and inflammatory pulmonary, hepatic, and dermal infiltrates. Antemortem and postmortem examinations revealed the presence of numerous mycobacteria in the bone marrow, spleen, kidneys, and lungs; these organisms failed to grow in vitro and were identified as M. genavense by 16S rRNA gene sequencing. This case illustrates that systemic M. genavense infections are not restricted to patients with AIDS but can also occur in otherwise immunocompromised patients.
authors.affiliation: Department for Internal Medicine III, University of Erlangen, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Bogdan
authors.forename: P
authors.initials: P
authors.lastname: Kern
authors.forename: E
authors.initials: E
authors.lastname: Richter
authors.forename: A
authors.initials: A
authors.lastname: Tannapfel
authors.forename: S
authors.initials: S
authors.lastname: Rüsch-Gerdes
authors.forename: T
authors.initials: T
authors.lastname: Kirchner
authors.forename: W
authors.initials: W
authors.lastname: Solbach
mesh_terms: D005260:Female; D018023:HIV Seronegativity; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D008875:Middle Aged; D009164:Mycobacterium Infections / Q000209:etiology*
chemical_list: D007166:Immunosuppressive Agents