Signalling through the lipid products of phosphoinositide-3-OH kinase.
When a stimulatory agonist molecule binds at the exterior of the cell membrane, a second messenger transduces the signal to the interior of the cell. Second messengers can be derived from phospholipids in the membrane by the action of the enzymes phospholipase C or phosphoinositide-3-OH kinase (PI(3)K). PI(3)K is a key player in many cellular responses, including the movement of organelle membranes, shape alteration through rearrangement of cytoskeletal actin, transformation and chemotaxis. But how PI(3)K mediates these responses is only now becoming clear.
Toker
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Boston Biomedical Research Institute, Massachusetts 02114, USA. toker@bbri.harvard.edu
Cantley
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D000818:Animals; D001798:Blood Proteins / Q000378:metabolism; D002135:Calcium-Binding Proteins; D004789:Enzyme Activation; D006801:Humans; D008562:Membrane Glycoproteins / Q000378:metabolism; D008563:Membrane Lipids / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000378:metabolism; D019869:Phosphatidylinositol 3-Kinases; D010716:Phosphatidylinositols / Q000378:metabolism*; D010750:Phosphoproteins; D017853:Phosphotransferases (Alcohol Group Acceptor) / Q000378:metabolism*; D015290:Second Messenger Systems; D050857:Synaptotagmins; D018909:src Homology Domains
D001798:Blood Proteins; D002135:Calcium-Binding Proteins; D008562:Membrane Glycoproteins; D008563:Membrane Lipids; D009419:Nerve Tissue Proteins; D010716:Phosphatidylinositols; D010750:Phosphoproteins; C039077:platelet protein P47; D050857:Synaptotagmins; D019869:Phosphatidylinositol 3-Kinases; D017853:Phosphotransferases (Alcohol Group Acceptor)