Effect of different cytokines on the growth of Trypanosoma congolense cultured under axenic conditions.
We previously reported that susceptible BALB/c mice had high amounts of interleukin-4 (IL-4) and interleukin-10 (IL-10) in their plasma after infection with Trypanosoma congolense and the levels of these cytokines decreased dramatically after berenil treatment. These observations instigated us to speculate that these cytokines might be directly affecting the growth of these parasites. Previously, it was reported that interferon gamma (IFN-gamma) had a growth stimulatory effect on T. brucei brucei in vitro. Although recombinant murine IL-4, IL-10 and IFN-gamma used in this study were biologically active, none of these cytokines had any growth stimulatory or inhibitory effect on T. congolense in vitro.
Kaushik
R S
RS
Department of Veterinary Microbiology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Canada.
Uzonna
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Tabel
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D000818:Animals; D001769:Blood; D003470:Culture Media; D006041:Goats / Q000097:blood; D007371:Interferon-gamma / Q000494:pharmacology*; D016753:Interleukin-10 / Q000494:pharmacology*; D015847:Interleukin-4 / Q000494:pharmacology*; D051379:Mice; D008807:Mice, Inbred BALB C; D011994:Recombinant Proteins / Q000494:pharmacology; D014348:Trypanosoma congolense / Q000187:drug effects / Q000254:growth & development*
D003470:Culture Media; D011994:Recombinant Proteins; D016753:Interleukin-10; D015847:Interleukin-4; D007371:Interferon-gamma