title: [Arterial-venous carbon dioxide tension difference after hypothermic cardiopulmonary bypass].
abstract: Arterial-venous carbon dioxide tension difference (Pv-aCO2) is known to become high after severe hemorrhage shock and resuscitation. We hypothesized that Pv-aCO2 might be high after cardiac surgery because of the oxygen debt occurred during hypothermic cardiopulmonary bypass (CPB). Blood pressure, cardiac index, hemoglobin, the arterial and mixed venous blood gases were repeatedly measured every 6 hours for 24 hours following cardiac surgery in 60 adult patients who underwent hypothermic CPB. Immediately after the surgery, Pv-aCO2 was extremely high, then gradually decreased to within normal ranges 12 hours later (8.0 +/- 2.9 mmHg vs 5.9 +/- 3.1 mmHg. p < 0.01). Factors which significantly correlated to Pv-aCO2 were cardiac index, oxygen delivery, minimum rectal temperature and duration of CPB. Oxygen debt during hypothermic CPB might cause significantly high Pv-aDO2. At least 12 hours were necessary to recover from anaerobic status to physiological condition.
authors.affiliation: First Department of Surgery, Kumamoto University School of Medicine, Japan.
authors.forename: J
authors.initials: J
authors.lastname: Utoh
authors.forename: S
authors.initials: S
authors.lastname: Moriyama
authors.forename: H
authors.initials: H
authors.lastname: Goto
authors.forename: T
authors.initials: T
authors.lastname: Hirata
authors.forename: R
authors.initials: R
authors.lastname: Kunitomo
authors.forename: M
authors.initials: M
authors.lastname: Hara
authors.forename: N
authors.initials: N
authors.lastname: Kitamura
mesh_terms: D000328:Adult; D000368:Aged; D001158:Arteries; D001794:Blood Pressure; D002245:Carbon Dioxide / Q000097:blood*; D006348:Cardiac Surgical Procedures; D002315:Cardiopulmonary Bypass; D005260:Female; D006801:Humans; D007036:Hypothermia, Induced; D008297:Male; D008875:Middle Aged; D010101:Oxygen Consumption; D010313:Partial Pressure; D011184:Postoperative Period; D012771:Shock, Hemorrhagic / Q000503:physiopathology; D014680:Veins
chemical_list: D002245:Carbon Dioxide