title: Evaluation of peri-infarcted hypoperfusion with T2*-weighted dynamic MRI.
abstract: The purpose of this study was to evaluate cerebral perfusion with T2*-weighted dynamic MRI in the area around the infarcted core. We examined seven patients with subacute cerebral infarction. After bolus injection a gadopentetate dimeglumine, a series of gradient-echo images were recorded in a selected slice. From these images, concentration-time curves were created on a region-of-interest (ROI) basis around infarction for calculating relative regional cerebral blood volume (rrCBV). Brain perfusion single photon emission computed tomography (SPECT) study also was performed with intravenous injection of 123I-labeled N-isopropyl-p-iodoamphetamine (123I-IMP). All patients showed prolonged signal decrease in the area around the infarcted core. ROI analysis showed significantly increased rrCBV compared to the normal side (P < .01, paired t test). The 123I-IMP SPECT study showed that these areas had decreased cerebral blood flow. Theses findings suggest compensatory vascular dilatation due to decreased perfusion pressure. T2*-weighted dynamic MRI is a useful method for detecting compensatory vasodilatation of ischemic insult in the peri-infarcted area.
authors.affiliation: Department of Radiology, Fukui Medical School, Japan.
authors.forename: C
authors.initials: C
authors.lastname: Tsuchida
authors.forename: H
authors.initials: H
authors.lastname: Yamada
authors.forename: M
authors.initials: M
authors.lastname: Maeda
authors.forename: N
authors.initials: N
authors.lastname: Sadato
authors.forename: T
authors.initials: T
authors.lastname: Matsuda
authors.forename: Y
authors.initials: Y
authors.lastname: Kawamura
authors.forename: N
authors.initials: N
authors.lastname: Hayashi
authors.forename: K
authors.initials: K
authors.lastname: Yamamoto
authors.forename: Y
authors.initials: Y
authors.lastname: Yonekura
authors.forename: Y
authors.initials: Y
authors.lastname: Ishii
mesh_terms: D000368:Aged; D001921:Brain / Q000098:blood supply*; D002545:Brain Ischemia / Q000175:diagnosis / Q000473:pathology; D002544:Cerebral Infarction / Q000175:diagnosis / Q000473:pathology*; D003937:Diagnosis, Differential; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D012680:Sensitivity and Specificity; D015899:Tomography, Emission-Computed, Single-Photon