Unbalanced t(4;11)(q32;q23) in a 34-year-old man with manifestations of distal monosomy 11q and trisomy 4q syndromes.
We present a 34-year-old man with an unbalanced translocation between the long arms of chromosome 4 and chromosome 11. He had manifestations of monosomy 11(q23)--minor facial anomalies, abnormal head shape, cryptorchidism; trisomy 4(q32)--hirsutism, renal disease; and manifestations attributable to both imbalances--heart disease, musculoskeletal anomalies, and mental retardation. FISH studies showed that the chromosome 11q23.3 translocation breakpoint was distal to the rare folate sensitive fragile site (FRA11B). The patient is the oldest reported with both imbalance of 4q+ and 11q-.
Byatt
S A
SA
Cytogenetics Laboratory, Royal North Shore Hospital, St. Leonards, Sydney, Australia.
Baker
E
E
Richards
R I
RI
Roberts
C
C
Smith
A
A
D000328:Adult; D002880:Chromosomes, Human, Pair 11; D002894:Chromosomes, Human, Pair 4; D005145:Face / Q000002:abnormalities; D005260:Female; D006257:Head / Q000002:abnormalities; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008607:Intellectual Disability / Q000235:genetics; D008297:Male; D009006:Monosomy / Q000235:genetics*; D009139:Musculoskeletal Abnormalities; D010641:Phenotype; D014178:Translocation, Genetic / Q000235:genetics*; D014314:Trisomy / Q000235:genetics*