title: Two new nitrogenous sesquiterpenes from the sponge Axinyssa aplysinoides.
abstract: Bioassay-guided fractionation of the EtOAc extract of the Palauan sponge Axinyssa aplysinoides yielded two novel alkaloids, 1 and 2. The structure of 2-(formylamino)trachyopsane (1) was determined by X-ray analysis; and the structure of N-phenethyl-N'-2-trachyopsanylurea (2), by interpretation of the spectral data.
authors.affiliation: Department of Biomolecular Discovery, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406-0939, USA.
authors.forename: A D
authors.initials: AD
authors.lastname: Patil
authors.forename: A J
authors.initials: AJ
authors.lastname: Freyer
authors.forename: R
authors.initials: R
authors.lastname: Reichwein
authors.forename: M F
authors.initials: MF
authors.lastname: Bean
authors.forename: L
authors.initials: L
authors.lastname: Faucette
authors.forename: R K
authors.initials: RK
authors.lastname: Johnson
authors.forename: R C
authors.initials: RC
authors.lastname: Haltiwanger
authors.forename: D S
authors.initials: DS
authors.lastname: Eggleston
mesh_terms: D016587:Antimutagenic Agents / Q000302:isolation & purification* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D004249:DNA Damage; D004260:DNA Repair / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism; D012717:Sesquiterpenes / Q000302:isolation & purification* / Q000494:pharmacology; D016339:Spectrometry, Mass, Fast Atom Bombardment; D014508:Urea / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: C106395:2-(formylamino)trachyopsane; D016587:Antimutagenic Agents; C106396:N-phenethyl-N'-2-trachyopsanylurea; D012717:Sesquiterpenes; D014508:Urea