The role of 15-lipoxygenase in atherogenesis: pro- and antiatherogenic actions.
Oxidative modification converts LDL to an atherogenic form and 15-lipoxygenase has been implicated in this process. Several lines of experimental evidence support such a proatherogenic action of the enzyme. However, recent data obtained with transgenic rabbits overexpressing 15-lipoxygenase suggest also an antiatherogenic effect. In this paper the pathophysiological relevance of 15-lipoxygenase in atherogenesis is critically reviewed.
Kühn
H
H
Institute of Biochemistry, University Clinics Charité, Humboldt University, Berlin, Germany.
Chan
L
L
D000818:Animals; D001093:Arachidonate 15-Lipoxygenase / Q000235:genetics / Q000378:metabolism*; D001161:Arteriosclerosis / Q000201:enzymology*; D005786:Gene Expression Regulation; D006801:Humans
D001093:Arachidonate 15-Lipoxygenase