[Differences in the effects of piracetam and fenazepam in emotional stress caused by the spatial reversal of a habit].
Emotional stress was caused in rats by changing the location of the gate in the shuttle chamber through which training had been accomplished in the previous experiments. The procedure led to disorder of the avoidance response (AR) and increase of intertrial responses (ITR). Phenazepam (0.1 mg/kg) prevented increase in the number of ITS. Piracetam (300 mg/kg) reduced the sharp growth of ISR but, in contrast to phenazepam, it provided a higher level of AR reproduction. The ISR were greater in piracetam than in phenazepam administration. The obtained results show that the suggested model allows the difference in the effects of piracetam and phenazepam to be disclosed.
Inozemtsev
A N
AN
Voronina
T A
TA
Pragina
L L
LL
Krutikova
I A
IA
Tushmalova
N A
NA
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001569:Benzodiazepines; D001570:Benzodiazepinones / Q000494:pharmacology / Q000627:therapeutic use*; D003214:Conditioning, Classical / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D004924:Escape Reaction / Q000187:drug effects; D008297:Male; D018697:Nootropic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D010889:Piracetam / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D012193:Reversal Learning / Q000187:drug effects*; D013037:Spatial Behavior / Q000187:drug effects*; D013315:Stress, Psychological / Q000188:drug therapy* / Q000209:etiology
D014151:Anti-Anxiety Agents; D001570:Benzodiazepinones; D018697:Nootropic Agents; D001569:Benzodiazepines; C017928:phenazepam; D010889:Piracetam