Controlling elements in replication of the human immunodeficiency virus type 1.
We have reviewed the genetic structure of HIV-1 from the perspective of understanding viral and cellular regulatory factors that affect viral replication. Comparisons are drawn, as appropriate, with other human retroviruses, such as HIV-2, in regard to our understanding of pathogenesis. The synthesis of viral protein and the manner in which viral assembly takes place is also discussed.
Li
X
X
McGill AIDS Centre, Jewish General Hospital, Montréal, Québec, Canada.
Quan
Y
Y
Wainberg
M A
MA
D015685:Fusion Proteins, gag-pol / Q000235:genetics / Q000502:physiology; D015686:Gene Products, env / Q000235:genetics / Q000502:physiology; D015683:Gene Products, gag / Q000235:genetics / Q000502:physiology; D015694:Gene Products, rev / Q000235:genetics / Q000502:physiology; D015696:Gene Products, tat / Q000235:genetics / Q000502:physiology; D015497:HIV-1 / Q000235:genetics / Q000254:growth & development / Q000502:physiology*; D006801:Humans; D012191:Retroviridae Proteins / Q000235:genetics / Q000502:physiology; D014158:Transcription, Genetic; D016662:Virus Integration; D014779:Virus Replication / Q000235:genetics / Q000502:physiology*; D054321:rev Gene Products, Human Immunodeficiency Virus; D054322:tat Gene Products, Human Immunodeficiency Virus
D015685:Fusion Proteins, gag-pol; D015686:Gene Products, env; D015683:Gene Products, gag; D015694:Gene Products, rev; D015696:Gene Products, tat; D012191:Retroviridae Proteins; D054321:rev Gene Products, Human Immunodeficiency Virus; D054322:tat Gene Products, Human Immunodeficiency Virus