Effect of KW-5092, novel gastroprokinetic agent, on the peristalsis in the isolated guinea pig ileum.
We examined the effect of KW-5092, a gastroprokinetic agent with acetylcholinesterase inhibitory and acetylcholine release facilitatory activities, on the peristalsis of isolated guinea pig ileum. KW-5092 (10(-9)-3 x 10(-6)M) increased the frequency of the peristaltic wave without changing its amplitude. Neostigmine increased the frequency at 10(-7) M, but domperidone (10(-8)-3 x 10(-6)M) had no effect on the peristalsis. The present results suggest that KW-5092 enhances the peristalsis via the inhibition of acetylcholinesterase, resulting in the intestinal propulsion.
Suzuki
M
M
Department of Pharmacology, Kyowa Hakko Kogyo Co., Ltd., Shizuoka, Japan.
Kishibayashi
N
N
Yokoyama
T
T
Karasawa
A
A
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D002800:Cholinesterase Inhibitors / Q000494:pharmacology*; D004294:Domperidone / Q000494:pharmacology; D018492:Dopamine Antagonists / Q000494:pharmacology; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects*; D007093:Imidazoles / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D018727:Muscarinic Antagonists / Q000494:pharmacology; D009388:Neostigmine / Q000494:pharmacology; D009570:Nitriles / Q000494:pharmacology*; D010528:Peristalsis / Q000187:drug effects*
D002800:Cholinesterase Inhibitors; D018492:Dopamine Antagonists; D007093:Imidazoles; D018727:Muscarinic Antagonists; D009570:Nitriles; C081341:KW 5092; D009388:Neostigmine; D004294:Domperidone; D001285:Atropine