title: Neurotensin increases intestinal adaptation and reduces enteroglucagon-like immunoreactivity after large bowel resection in rats.
abstract: OBJECTIVE
  To assess the effects of giving neurotensin on intestinal adaptation after colectomy and their relation to enteroglucagon-like immunoreactivity.
  
  
  METHODS
  Laboratory experiment.
  
  
  METHODS
  Teaching hospital, Spain.
  
  
  METHODS
  55 Male Wistar rats.
  
  
  METHODS
  All animals were anaesthetised before undergoing laparotomy; 24 animals had 75% of their colon resected. Half of the animals (12 in each group) were treated with neurotensin (600 micrograms/kg body wt/day) for 14 days.
  
  
  METHODS
  Differences in the number of mitoses and in nuclear antigen staining of proliferating cells in the intestinal mucosal crypts; plasma enteroglucagon-like immunoreactivity.
  
  
  RESULTS
  After colon resection, the proliferative status, number of mitoses (p < 0.01), and nuclear antigen staining of proliferating cells (p < 0.001) increased significantly in the jejunum of animals treated with neurotensin (p < 0.05). Less pronounced effects were observed in colon and ileum. Plasma enteroglucagon-like immunoreactivity levels fell significantly in all animals given neurotensin (p < 0.05).
  
  
  CONCLUSIONS
  Neurotensin increases the adaptive intestinal process after colon resection and reduces plasma enteroglucagon-like immunoreactivity in rats.
authors.affiliation: Service of Experimental Surgery, Hospital La Paz, Madrid, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Mata
authors.forename: I A
authors.initials: IA
authors.lastname: Gómez de Segura
authors.forename: C
authors.initials: C
authors.lastname: Largo
authors.forename: J
authors.initials: J
authors.lastname: Codesal
authors.forename: E
authors.initials: E
authors.lastname: De Miguel
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D002455:Cell Division; D003082:Colectomy; D005260:Female; D007413:Intestinal Mucosa / Q000502:physiology; D007583:Jejunum / Q000502:physiology*; D008297:Male; D009496:Neurotensin / Q000502:physiology*; D018809:Proliferating Cell Nuclear Antigen; D051381:Rats; D017208:Rats, Wistar; D012680:Sensitivity and Specificity
chemical_list: D018809:Proliferating Cell Nuclear Antigen; D009496:Neurotensin