title: Effects of AMI-25 on liver vessels and tumors on T1-weighted turbo-field-echo images: implications for tumor characterization.
abstract: This study was devoted to tumor differentiation in liver MR T1-weighted imaging with superparamagnetic iron oxide (SPIO). Twenty-one patients with 40 liver lesions were studied at 1.5 T. Before and at least 45 minutes after SPIO administration, turbo-field-echo (TFE) T1-weighted, TFE T1 x T2*-weighted (MXT), and fat-suppressed turbo-spin-echo T2-weighted images were acquired. A quantitative analysis was performed blindly. On TFE T1-weighted images, the signal enhancement was -33% +/- 12 for the liver, -24% +/- 2 for adenomas and focal nodular hyperplasia, +60% +/- 33 for the hemangiomas; metastases and cyst enhancement were not significant. After SPIO on TFE T1-weighted images, the hemangioma-to-liver signal ratio (149% +/- 18) was definitely higher than the mean metastasis-to-liver signal ratio (90% +/- 16). This T1-related differentiation ability lacked dramatically on TFE MXT images and, in one case, was reduced on post-SPIO TFE T1-weighted images by a long imaging delay after SPIO administration (2 hours).
authors.affiliation: Department of Radiology, Hôpital Erasme, Route de Lennik, Brussels, Belgium.
authors.forename: D
authors.initials: D
authors.lastname: van Gansbeke
authors.forename: T M
authors.initials: TM
authors.lastname: Metens
authors.forename: C
authors.initials: C
authors.lastname: Matos
authors.forename: N
authors.initials: N
authors.lastname: Nicaise
authors.forename: F
authors.initials: F
authors.lastname: Gay
authors.forename: H
authors.initials: H
authors.lastname: Raeymaekers
authors.forename: J
authors.initials: J
authors.lastname: Struyven
mesh_terms: D000328:Adult; D000368:Aged; D003287:Contrast Media / Q000008:administration & dosage*; D003911:Dextrans; D003937:Diagnosis, Differential; D004578:Electron Spin Resonance Spectroscopy; D005260:Female; D052203:Ferrosoferric Oxide; D006391:Hemangioma / Q000098:blood supply* / Q000175:diagnosis*; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007501:Iron / Q000008:administration & dosage*; D008113:Liver Neoplasms / Q000098:blood supply* / Q000175:diagnosis* / Q000556:secondary; D008279:Magnetic Resonance Imaging; D058185:Magnetite Nanoparticles; D008297:Male; D008875:Middle Aged; D010087:Oxides / Q000008:administration & dosage*; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed
chemical_list: D003287:Contrast Media; D003911:Dextrans; D058185:Magnetite Nanoparticles; D010087:Oxides; D007501:Iron; C065507:ferumoxides; D052203:Ferrosoferric Oxide