title: Pseudorabies virus infections in pigs. Role of viral proteins in virulence, pathogenesis and transmission.
abstract: This paper reviews new findings on the biological functions of pseudorabies virus (PRV) proteins. It focuses on the role of PRV proteins in the pathogenicity, immunogenicity and transmission of PRV vaccine strains in pigs. Furthermore, it evaluates potential risks that are connected with the use of PRV vector strains. Special emphasis is placed upon the spread of genetically engineered vaccine strains within pigs or between pigs.
authors.affiliation: Department of Pathobiology and Epidemiology, Institute for Animal Science and Health (ID-DLO), Lelystad, The Netherlands. WAMMulder@ID.DLO.NL
authors.forename: W A
authors.initials: WA
authors.lastname: Mulder
authors.forename: J M
authors.initials: JM
authors.lastname: Pol
authors.forename: E
authors.initials: E
authors.lastname: Gruys
authors.forename: L
authors.initials: L
authors.lastname: Jacobs
authors.forename: M C
authors.initials: MC
authors.lastname: De Jong
authors.forename: B P
authors.initials: BP
authors.lastname: Peeters
authors.forename: T G
authors.initials: TG
authors.lastname: Kimman
mesh_terms: D000818:Animals; D004199:Disease Vectors; D016679:Genome, Viral; D011558:Herpesvirus 1, Suid / Q000235:genetics / Q000276:immunology / Q000472:pathogenicity*; D011494:Protein Kinases / Q000502:physiology; D011557:Pseudorabies / Q000276:immunology / Q000635:transmission / Q000821:virology*; D022421:Pseudorabies Vaccines; D012264:Ribonucleotide Reductases / Q000502:physiology; D013552:Swine; D013553:Swine Diseases / Q000276:immunology / Q000635:transmission / Q000821:virology*; D013937:Thymidine Kinase / Q000502:physiology; D014613:Vaccines, Attenuated / Q000009:adverse effects / Q000235:genetics / Q000592:standards; D014759:Viral Envelope Proteins / Q000502:physiology; D014764:Viral Proteins / Q000502:physiology*; D014765:Viral Vaccines / Q000009:adverse effects / Q000235:genetics / Q000592:standards; D014774:Virulence; D019065:Virus Assembly / Q000502:physiology; D014779:Virus Replication / Q000502:physiology
chemical_list: D022421:Pseudorabies Vaccines; D014613:Vaccines, Attenuated; D014759:Viral Envelope Proteins; D014764:Viral Proteins; D014765:Viral Vaccines; C042966:pseudorabies virus glycoproteins; D012264:Ribonucleotide Reductases; D011494:Protein Kinases; D013937:Thymidine Kinase