Novel indices of oxidant stress in cardiovascular disease: specific analysis of F2-isoprostanes.
The development of methods to measure specific isoprostanes affords a unique opportunity to investigate both the role of oxidant stress as a mechanism of disease in vivo and to select rational doses of putative antioxidant drugs and vitamins for evaluation in human disease. The ability to measure these compounds directly in situ at the site of their formation, to immunolocalize them to target cells in atherosclerotic plaque and other tissues (61) and to assess their biosynthesis non-invasively in urine promises to elucidate the role of lipid peroxidation in cardiovascular disease.
Praticò
D
D
Center for Experimental Therapeutics, University of Pennsylvania, Philadelphia, USA.
Reilly
M
M
Lawson
J A
JA
FitzGerald
G A
GA
D000818:Animals; D002318:Cardiovascular Diseases / Q000378:metabolism*; D015237:Dinoprost / Q000032:analysis / Q000378:metabolism*; D006801:Humans; D015227:Lipid Peroxidation; D018384:Oxidative Stress; D017382:Reactive Oxygen Species / Q000378:metabolism*
D017382:Reactive Oxygen Species; D015237:Dinoprost