Novel conformationally extended naphthalene-based inhibitors of farnesyltransferase.
Burns
C J
CJ
Rhône-Poulenc Rorer S.A., Centre de Recherches de Vitry-Alfortville, Vitry-sur-Seine, France. burnscj@rpr.rpna.com
Guitton
J D
JD
Baudoin
B
B
Lelièvre
Y
Y
Duchesne
M
M
Parker
F
F
Fromage
N
N
Commerçon
A
A
D015081:2-Naphthylamine / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D019883:Alkyl and Aryl Transferases; D000595:Amino Acid Sequence; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D002461:Cell Line, Transformed; D003545:Cysteine / Q000737:chemistry; D004151:Dipeptides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D051231:Farnesyltranstransferase; D011905:Genes, ras; D008715:Methionine / Q000737:chemistry; D008958:Models, Molecular; D015394:Molecular Structure; D009281:Naphthalenes / Q000737:chemistry*; D011487:Protein Conformation; D013329:Structure-Activity Relationship; D014166:Transferases / Q000037:antagonists & inhibitors*; D014407:Tumor Cells, Cultured; D018631:ras Proteins / Q000378:metabolism
D000970:Antineoplastic Agents; D004151:Dipeptides; D004791:Enzyme Inhibitors; D009281:Naphthalenes; C106582:RPR 114334; C031721:naphthalene; D008715:Methionine; D015081:2-Naphthylamine; D014166:Transferases; D019883:Alkyl and Aryl Transferases; D051231:Farnesyltranstransferase; D018631:ras Proteins; D003545:Cysteine