[Bullous mastocytosis in a child].
We report a case of bullous mastocytosis in a 30-month-old girl, who developed disseminated pruritic urticarial and bullous lesions on the trunk accompanied by episodes of vomiting and generalized flushing. Her problems began at the age of 6 months. Her stool was repeatedly positive for occult blood. Histamine and 5-hydroxytryptamine were measured in the urine and serum; urine 5-hydroxytryptamine levels were elevated. In addition, trypsin and chymotrypsin levels were raised in the blister fluid. Metachromatic staining of the mast cells in a skin biopsy specimen confirmed the diagnosis. A combination of oral disodium cromoglycate and ketotifen produced a dramatic improvement of the cutaneous and gastrointestinal features.
Haustein
U F
UF
Klinik und Poliklinik für Hautkrankheiten, Universität, Leipzig.
Bedri
M
M
D002675:Child, Preschool; D004205:Cromolyn Sodium / Q000008:administration & dosage; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007665:Ketotifen / Q000008:administration & dosage; D012867:Skin / Q000473:pathology; D014582:Urticaria Pigmentosa / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology
D004205:Cromolyn Sodium; D007665:Ketotifen