Pediatric lung transplantation.
Pediatric lung transplantation is becoming more common, and with increasing experience there is increasing success. The most common indications for considering lung transplantation are cystic fibrosis, pulmonary vascular disease (usually due to congenital heart disease), and fibrotic lung disease. The contraindications and complications are similar to adult transplant patients, although post-transplant lymphoproliferative disease and airway complications may occur more frequently. The patients with cystic fibrosis face additional obstacles to the success of transplantation: airway colonization with Gram-negative organisms, pancreatic insufficiency, glucose intolerance, and osteoporosis. The survival for children is comparable to adults, reaching about 65% at 1 year, and 69% at 2 years.
Stillwell
P C
PC
Department of Pediatrics, Cleveland Clinic Foundation, Ohio, USA.
Mallory
G B
GB
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D000075202:Contraindications; D003550:Cystic Fibrosis / Q000601:surgery*; D006801:Humans; D006976:Hypertension, Pulmonary / Q000601:surgery*; D007223:Infant; D007231:Infant, Newborn; D016040:Lung Transplantation / Q000009:adverse effects / Q000379:methods / Q000401:mortality; D018579:Patient Selection; D011658:Pulmonary Fibrosis / Q000601:surgery*; D016019:Survival Analysis; D016896:Treatment Outcome