[Indometofen causes biochemical changes in the blood cells characteristic for a radioresistant state of the body].
The DNA and RNA contents, RNA/DNA ratio, and spontaneous and latex-induced oxidant activity indices of the whole blood were studied in the nitroblue tetrazolium test of mono- and polymorphonuclear blood leucocytes of intact dogs after injection of lipopolysaccharide pyrogenal. Significant changes in the above parameters were revealed for radioresistant (survived) and radiosensitive (lost) animals exposed to a subsequent prolonged gamma irradiation with a lethal dose of 7.64 Gy (LD75/45). Peroral introduction of 30 mg/kg indometofen (an indole analog of tamoxifen), which is a potential radioprotector, to dogs increased the survival rates of the irradiated dogs up to 93% and aided in the adaptive biochemical changes in the nuclear cell compartment of blood to induce a radioresistant status of the organism.
Mazurik
V K
VK
Mikhaĭlov
V F
VF
Ushenkova
L N
LN
Vodolazskaia
N A
NA
Raeva
N F
NF
Chernov
G A
GA
Shliakova
T G
TG
Borovkov
M V
MV
D000818:Animals; D001773:Blood Cells / Q000187:drug effects* / Q000378:metabolism / Q000528:radiation effects; D004247:DNA / Q000097:blood / Q000187:drug effects / Q000528:radiation effects; D003692:Delayed-Action Preparations; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D005260:Female; D008297:Male; D012313:RNA / Q000097:blood / Q000187:drug effects / Q000528:radiation effects; D011833:Radiation Injuries, Experimental / Q000097:blood / Q000401:mortality / Q000517:prevention & control; D011836:Radiation Tolerance / Q000187:drug effects* / Q000502:physiology; D011837:Radiation-Protective Agents / Q000494:pharmacology* / Q000627:therapeutic use; D013629:Tamoxifen / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D014916:Whole-Body Irradiation / Q000009:adverse effects
D003692:Delayed-Action Preparations; D011837:Radiation-Protective Agents; C091454:indometafen; D013629:Tamoxifen; D012313:RNA; D004247:DNA