title: Women's reproductive health: the role of body mass index in early and adult life.
abstract: BACKGROUND
  Higher risks of menstrual problems and infertility have been found in underweight and overweight women but evidence is inconsistent especially in relation to the effect of age of onset of obesity.
  
  
  OBJECTIVE
  To determine whether body mass index (BMI) in adulthood or childhood affects the reproductive health of women.
  
  
  METHODS
  Heights, weights (at 7, 11, 16, 23 and 33y) and reproductive data were available for 5799 females in the 1958 British birth cohort study. Body mass index (BMI) was calculated as weight/height2. Age-specific cut-offs were used to define overweight and obesity. Reproductive outcomes reported at age 33 included: menstrual problems (also reported at 16y), hypertension in pregnancy and subfertility.
  
  
  RESULTS
  Early menarcheal age was associated with higher risks of menstrual problems by 16y but this relationship did not persist to 33y. Obesity at 23y and obesity at 7y both independently increased the risk of menstrual problems by age 33 (OR = 1.75, OR = 1.59 respectively) after adjusting for other confounding factors. Obesity at 23y increased the risk of hypertension in pregnancy (OR = 2.37), after adjusting for confounders. Consistent with these findings, obese women at 23y were less likely to conceive within 12 months of unprotected intercourse after adjustment for confounders (RR = 0.69).
  
  
  CONCLUSIONS
  Overweight and obesity in early adulthood appears to increase the risk of menstrual problems, hypertension in pregnancy and subfertility. Other than menstrual problems, childhood body mass index had little impact on the reproductive health of women.
authors.affiliation: Department of Epidemiology & Biostatistics, Institute of Child Health, London, UK.
authors.forename: J K
authors.initials: JK
authors.lastname: Lake
authors.forename: C
authors.initials: C
authors.lastname: Power
authors.forename: T J
authors.initials: TJ
authors.lastname: Cole
mesh_terms: D000293:Adolescent; D000328:Adult; D000375:Aging; D015992:Body Mass Index; D002648:Child; D005260:Female; D006801:Humans; D006973:Hypertension / Q000453:epidemiology; D007247:Infertility, Female / Q000453:epidemiology; D008599:Menstruation Disturbances / Q000453:epidemiology; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000453:epidemiology; D012098:Reproduction; D012307:Risk Factors; D016387:Women's Health