A fatal case of betaxolol poisoning.
We report the first case in the literature of fatal betaxolol (Kerlone) self-poisoning. After a single-step liquid-liquid alkaline extraction, betaxolol was identified by a high-performance liquid chromatographic-diode array detection screening procedure and then quantitated in cardiac blood, heart, brain, muscle, spleen, stomach contents, duodenum contents, liver, and kidney. The blood betaxolol concentration was 36 mg/L.
Berthault
F
F
Institut de Médecine Légale, Strasbourg, France.
Kintz
P
P
Tracqui
A
A
Mangin
P
P
D000319:Adrenergic beta-Antagonists / Q000097:blood / Q000378:metabolism / Q000506:poisoning*; D000328:Adult; D001344:Autopsy; D015784:Betaxolol / Q000097:blood / Q000378:metabolism / Q000506:poisoning*; D001921:Brain / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D005260:Female; D005766:Gastrointestinal Contents / Q000737:chemistry; D006801:Humans; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D009132:Muscles / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D012015:Reference Standards; D013154:Spleen / Q000378:metabolism; D013405:Suicide; D014018:Tissue Distribution
D000319:Adrenergic beta-Antagonists; D015784:Betaxolol