title: Oral granular cell tumours: a histological and immunocytochemical study.
abstract: In a series of nine cases of intra-oral granular cell tumors (GCTs) an attempt was made, using both histochemical and immunocytochemical methods, to determine whether these tumours show Schwann-cell or neuroendocrine differentiation. Positive immunostaining with protein gene product 9.5 (PGP 9.5), neurone-specific enolase (NSE) and S-100, in contrast to predominantly negative immunostaining in 12 cases of neurilemmoma of the head and neck, and a similar pattern of staining with luxol fast blue to five known neuroendocrine tumours, strongly suggests that granular cell tumors may be neuroendocrine in nature.
authors.affiliation: School of Dentistry, University of Birmingham, UK.
authors.forename: H K
authors.initials: HK
authors.lastname: Williams
authors.forename: D M
authors.initials: DM
authors.lastname: Williams
mesh_terms: D000293:Adolescent; D000328:Adult; D014408:Biomarkers, Tumor; D019070:Cell Lineage; D053379:Chromogranin A; D002864:Chromogranins / Q000032:analysis; D003937:Diagnosis, Differential; D005260:Female; D016586:Granular Cell Tumor / Q000737:chemistry / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa / Q000737:chemistry / Q000473:pathology; D009062:Mouth Neoplasms / Q000737:chemistry / Q000473:pathology*; D004676:Myelin Basic Protein / Q000032:analysis; D018358:Neuroendocrine Tumors / Q000737:chemistry / Q000473:pathology*; D010751:Phosphopyruvate Hydratase / Q000032:analysis; D009418:S100 Proteins / Q000032:analysis; D012583:Schwann Cells; D013869:Thiolester Hydrolases / Q000032:analysis; D014062:Tongue Neoplasms / Q000737:chemistry / Q000473:pathology; D043222:Ubiquitin Thiolesterase
chemical_list: D014408:Biomarkers, Tumor; D053379:Chromogranin A; D002864:Chromogranins; D004676:Myelin Basic Protein; D009418:S100 Proteins; D013869:Thiolester Hydrolases; D043222:Ubiquitin Thiolesterase; D010751:Phosphopyruvate Hydratase