title: Gastrointestinal absorption, tissue retention, and urinary excretion of dietary aluminum in rats determined by using 26Al.
abstract: We used accelerator mass spectrometry (AMS) and 26AI to study the plasma concentration, urinary excretion, and retention in bone, brain, and liver of a single dose of a dietary concentration of aluminum ingested either with or without citrate by 2-month-old Wistar rats. In the absence of citrate, cumulative urinary excretion and skeleton retention were each approximately 0.05% of the total 26AI dose ingested. 26AI retention in brain and liver were approximately 4 x 10(-8) and 2 x 10(-6), respectively. Concomitant citrate intake increased these median values by about two- to fivefold, although this factor was highly variable in individual rats. Independent of citrate administration, 90% of the 26AI excreted in urine (measured cumulatively over 30 days) was excreted within the first 48 h. Uptake by bone was rapid (approximately 1 h) and permanent over the 30-day duration of the experiment.
authors.affiliation: Centre de Spectrométrie Nucléaire et de Spectrométrie de Masse (CSNSM), CNRS-IN2P3, Orsay, France.
authors.forename: P
authors.initials: P
authors.lastname: Jouhanneau
authors.forename: G M
authors.initials: GM
authors.lastname: Raisbeck
authors.forename: F
authors.initials: F
authors.lastname: Yiou
authors.forename: B
authors.initials: B
authors.lastname: Lacour
authors.forename: H
authors.initials: H
authors.lastname: Banide
authors.forename: T B
authors.initials: TB
authors.lastname: Drüeke
mesh_terms: D000418:Albumins / Q000493:pharmacokinetics*; D000419:Albuminuria / Q000652:urine*; D000818:Animals; D001921:Brain / Q000378:metabolism; D004032:Diet; D007408:Intestinal Absorption / Q000502:physiology*; D008099:Liver / Q000378:metabolism; D008297:Male; D013058:Mass Spectrometry; D011868:Radioisotopes; D051381:Rats; D017208:Rats, Wistar; D012709:Serum Albumin / Q000378:metabolism*; D013997:Time Factors; D014018:Tissue Distribution
chemical_list: D000418:Albumins; D011868:Radioisotopes; D012709:Serum Albumin