title: Experimental cryptosporidiosis in adult and neonatal rabbits.
abstract: Neonatal and adult New Zealand White rabbits were infected experimentally with Cryptosporidium parvum. No histologic evidence of infection was found in adult rabbits. However, increased levels of anti-cryptosporidial serum IgG were present, and multiple antigens were detected by serum on immunoblots. In neonates, variably severe, transient infection was present from Days 3 to 21 postinoculation. Serum IgG was initially elevated, decreased until Day 10 postinoculation, then progressively increased for the remainder of the study. A prominent 15 kilodalton antigen was detected on immunoblots using serum obtained on Days 14 until 28 postinoculation. Neonate anti-cryptosporidial fecal IgA were slightly elevated on Days 14 and 21 postinoculation.
authors.affiliation: Department of Pathology and Microbiology, College of Veterinary Medicine, Kansas State University, Manhattan 66506, USA.
authors.forename: D A
authors.initials: DA
authors.lastname: Mosier
authors.forename: K Y
authors.initials: KY
authors.lastname: Cimon
authors.forename: T L
authors.initials: TL
authors.lastname: Kuhls
authors.forename: R D
authors.initials: RD
authors.lastname: Oberst
authors.forename: K R
authors.initials: KR
authors.lastname: Simons
mesh_terms: D000375:Aging / Q000276:immunology*; D000818:Animals; D000831:Animals, Newborn; D000913:Antibodies, Protozoan / Q000097:blood; D000953:Antigens, Protozoan / Q000097:blood; D003457:Cryptosporidiosis / Q000097:blood / Q000276:immunology* / Q000469:parasitology; D016785:Cryptosporidium parvum / Q000276:immunology* / Q000302:isolation & purification; D007074:Immunoglobulin G / Q000097:blood; D011817:Rabbits
chemical_list: D000913:Antibodies, Protozoan; D000953:Antigens, Protozoan; D007074:Immunoglobulin G