Biological activity of purpurogallin.
Purpurogallin showed antibacterial activity toward gram-positive bacteria. Strong activity against methicillin-resistant Staphylococcus aureus [minimal inhibitory concentration (MIC) against methicillin of 1600 micrograms/ml] was found, with MIC of 11.0 micrograms/ml. Purpurogallin inhibited the growth of all tested plants and decreased the chlorophyll content in the cotyledons of Brassica campestris subsp. rapa. It showed potent inhibitory activity against prolyl endopeptidase (the 50% inhibitory concentration was 1.6 x 10(-5) M), unlike its analogues, hinokitiol and tropolone.
Inamori
Y
Y
Osaka University of Pharmaceutical Sciences, Japan.
Muro
C
C
Sajima
E
E
Katagiri
M
M
Okamoto
Y
Y
Tanaka
H
H
Sakagami
Y
Y
Tsujibo
H
H
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001567:Benzocycloheptenes / Q000494:pharmacology*; D001937:Brassica / Q000187:drug effects* / Q000254:growth & development; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D039821:Monoterpenes; D000085822:Prolyl Oligopeptidases; D012697:Serine Endopeptidases / Q000187:drug effects; D015842:Serine Proteinase Inhibitors / Q000494:pharmacology*; D014334:Tropolone / Q000031:analogs & derivatives / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D001567:Benzocycloheptenes; D039821:Monoterpenes; D015842:Serine Proteinase Inhibitors; D014334:Tropolone; D012697:Serine Endopeptidases; D000085822:Prolyl Oligopeptidases; C026133:purpurogallin; C009479:beta-thujaplicin