title: Focal cortical dysplasia of Taylor, balloon cell subtype: MR differentiation from low-grade tumors.
abstract: OBJECTIVE
  To test the hypothesis that focal cortical dysplasia of Taylor (FCDT) can be distinguished from low-grade tumors by means of clinical and MR findings.
  
  
  METHODS
  We examined 10 clinical and 19 MR imaging variables in patients who underwent surgery for intractable epilepsy over an 8-year period. The 54 patients with low-grade glial neoplasms were compared with the eight patients who had balloon cell FCDT.
  
  
  RESULTS
  Statistically significant differences were seen with respect to eight of the MR variables and none of the clinical variables. MR findings suggesting dysplasia rather than tumor included the presence of gray matter thickening associated with a homogeneous hyperintense signal in the subcortical white matter that tapers as it extends to the lateral ventricle. A frontal lobe location favors dysplasia, while a temporal lobe (especially medial temporal lobe) location is more suggestive of a neoplasm.
  
  
  CONCLUSIONS
  Several MR features help distinguish balloon cell FCDT from neoplasms, especially cortical thickening and a tapered signal to the ventricle. This distinction is important for surgical planning, as the decision to operate and the extent of surgical resection often depend on the presence or absence of neoplastic tissue.
authors.affiliation: Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, Conn 06510, USA.
authors.forename: R A
authors.initials: RA
authors.lastname: Bronen
authors.forename: K P
authors.initials: KP
authors.lastname: Vives
authors.forename: J H
authors.initials: JH
authors.lastname: Kim
authors.forename: R K
authors.initials: RK
authors.lastname: Fulbright
authors.forename: S S
authors.initials: SS
authors.lastname: Spencer
authors.forename: D D
authors.initials: DD
authors.lastname: Spencer
mesh_terms: D000293:Adolescent; D000328:Adult; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D002466:Cell Nucleolus / Q000473:pathology; D002540:Cerebral Cortex / Q000002:abnormalities* / Q000473:pathology; D002552:Cerebral Ventricles; D002648:Child; D003937:Diagnosis, Differential; D004827:Epilepsy / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D005260:Female; D005625:Frontal Lobe / Q000002:abnormalities / Q000473:pathology; D015726:Giant Cells / Q000473:pathology*; D005910:Glioma / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D013702:Temporal Lobe / Q000002:abnormalities / Q000473:pathology