title: Dirofilaria, visceral larva migrans, and tropical pulmonary eosinophilia.
abstract: Helminthic infections are prevalent worldwide. The intestinal ascarid, Toxocara, the animal filarial parasite, Dirofilaria, and the human filarial parasite, Wuchereria or Brugia, produce an array of pulmonary disease in humans. Infections are common in temperate, tropical, and subtropical regions of the world. Pulmonary dirofilariasis is essentially an asymptomatic disease. Most cases are diagnosed accidentally after thoracotomy for a solitary pulmonary nodule presumed to be lung cancer. Clinical manifestations of toxocariasis or visceral larva migrans (VLM) are the result of allergic and inflammatory responses of the host, and manifest with airway reactivity, acute pneumonia, and persistent eosinophilia. VLM is a self-limited disease and specific treatment is rarely necessary. In acute cases, a short course of steroids reduces morbidity and mortality but preventive measures are more important in curbing toxocara infection. Tropical pulmonary eosinophilia (TPE) is the result of immunologic hyperresponsiveness to the human filarial antigen and eosinophils play a crucial role in its pathogenesis. Airway hyperreactivity, extreme eosinophilia, and pulmonary physiologic impairment are the characteristic features. Treatment of TPE with diethylcarbamazine results in dramatic amelioration of symptoms. However, low grade inflammation persists in a significant number of patients and can lead to chronic interstitial lung disease. Mass treatment of patients in certain endemic areas has been effective in eliminating TPE.
authors.affiliation: Pulmonary and Critical Care Medicine, Stanford University Medical Center, Palo Alto, CA, USA.
authors.forename: R K
authors.initials: RK
authors.lastname: Chitkara
authors.forename: P S
authors.initials: PS
authors.lastname: Sarinas
mesh_terms: D000818:Animals; D001706:Biopsy; D004049:Diethylcarbamazine / Q000627:therapeutic use; D004183:Dirofilaria immitis / Q000254:growth & development; D004184:Dirofilariasis / Q000175:diagnosis / Q000188:drug therapy; D005369:Filaricides / Q000627:therapeutic use; D006801:Humans; D007816:Larva Migrans, Visceral / Q000175:diagnosis / Q000188:drug therapy; D008174:Lung Diseases, Parasitic / Q000175:diagnosis / Q000188:drug therapy; D011657:Pulmonary Eosinophilia / Q000175:diagnosis / Q000188:drug therapy; D014057:Tomography, X-Ray Computed
chemical_list: D005369:Filaricides; D004049:Diethylcarbamazine