title: Autologous fat implantation for vocal fold scar: a preliminary report.
abstract: New insights into the anatomy and physiology of phonation, along with technological advances in voice assessment and quantification, have led to dramatic improvements in medical voice care. Techniques to prevent vocal fold scar have been among the most important, especially scarring and hoarseness associated with voice surgery. Nevertheless, dysphonia due to vocal fold scar is still encountered all too frequently. Although it is not generally possible to restore such injured voices to normal, patients with scar-induced dysphonia can usually be helped. Voice improvement is optimized through a team approach. Treatment may include sophisticated voice therapy and vocal fold surgery. Although experience with collagen injection has been encouraging in selected cases (particularly in those involving limited areas of vocal fold scar), there is no consistently successful surgical technique. Attempts to treat massive vocal fold scar, such as may be seen following vocal fold stripping, have been particularly unsuccessful. This paper reports preliminary experience with the implantation of autologous fat into the vibratory margin of the vocal fold of patients with severe, extensive scarring. Using this technique, it appears possible to recreate a mucosal wave and improve voice quality. Additional research is needed.
authors.affiliation: Department of Otolaryngology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
authors.forename: R T
authors.initials: RT
authors.lastname: Sataloff
authors.forename: J R
authors.initials: JR
authors.lastname: Spiegel
authors.forename: M
authors.initials: M
authors.lastname: Hawkshaw
authors.forename: D C
authors.initials: DC
authors.lastname: Rosen
authors.forename: R J
authors.initials: RJ
authors.lastname: Heuer
mesh_terms: D000273:Adipose Tissue; D000293:Adolescent; D000328:Adult; D002921:Cicatrix / Q000150:complications / Q000601:surgery / Q000628:therapy; D003131:Combined Modality Therapy; D005260:Female; D006685:Hoarseness / Q000150:complications*; D006801:Humans; D007818:Laryngeal Diseases; D008297:Male; D014182:Transplantation, Autologous; D014827:Vocal Cords; D014832:Voice Disorders / Q000628:therapy; D014833:Voice Quality; D014834:Voice Training