title: Tolerability of nabumetone: a pilot in vitro study showing absence of injury to articular cartilage.
abstract: Nabumetone, a compound of the naphthylalkanone class, has shown considerable anti-inflammatory, analgesic and antipyretic effects, together with high systemic and organ-specific tolerability. Its reputation for tolerability has been increased by an in-vitro study evaluating the mature collagen metabolism's markers under nabumetone treatment, which shows that, nabumetone does not interfere with collagen synthesis. Therefore, unlike some nonsteroidal anti-inflammatory drugs, nabumetone might not be injurious to articular cartilage. This feature makes nabumetone even safer for long-term treatment of rheumatic and orthopaedic conditions.
authors.affiliation: Institute of Medical Pathology, University of Siena, Italy.
authors.forename: N
authors.initials: N
authors.lastname: Giordano
authors.forename: M
authors.initials: M
authors.lastname: Senesi
authors.forename: E
authors.initials: E
authors.lastname: Battisti
authors.forename: S
authors.initials: S
authors.lastname: Gonnelli
authors.forename: B
authors.initials: B
authors.lastname: Franci
authors.forename: M S
authors.initials: MS
authors.lastname: Campagna
authors.forename: G
authors.initials: G
authors.lastname: Mattii
authors.forename: F
authors.initials: F
authors.lastname: Palumbo
authors.forename: C
authors.initials: C
authors.lastname: Gennari
mesh_terms: D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects* / Q000493:pharmacokinetics; D002074:Butanones / Q000009:adverse effects* / Q000493:pharmacokinetics; D002358:Cartilage, Articular / Q000187:drug effects*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D000077430:Nabumetone; D010865:Pilot Projects; D011355:Prodrugs / Q000009:adverse effects* / Q000493:pharmacokinetics; D012216:Rheumatic Diseases / Q000188:drug therapy*; D013583:Synovial Membrane / Q000187:drug effects / Q000378:metabolism
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D002074:Butanones; D011355:Prodrugs; D000077430:Nabumetone