Neoplasia in ileal pouch mucosa after total proctocolectomy for juvenile polyposis: report of a case.
OBJECTIVE
Patients treated with restorative proctocolectomy for familial adenomatous polyposis or ulcerative colitis occasionally develop disease in the ileal pouch similar to that originally present in the colon. We investigated the possibility of analogous involvement in the ileal pouch of juvenile polyposis patients.


METHODS
Endoscopic surveillance for neoplasia throughout the gastrointestinal tract was performed, with retrieval of all polypectomy specimens for histologic classification using the criteria of Morson.


RESULTS
Multiple large juvenile polyps were found in the ileal pouch of one patient less than 10 years after restorative proctocolectomy for hereditary juvenile polyposis. The pouch was much more severely affected than the proximal ileum, small intestine, or stomach. Although most polyps had a completely benign histologic appearance, three had moderate to severe dysplasia.


CONCLUSIONS
Mucosal changes induced by bacteria or stasis of luminal contents may promote manifestation in the ileal pouch of the disease phenotype usually more evident in the colon. Patients with severe or generalized juvenile polyposis should be considered for periodic endoscopic surveillance of the ileal pouch beginning several years after restorative proctocolectomy.
Stoltenberg
R L
RL
Department of Surgery, University of Wisconsin, Madison 53792, USA.
Madsen
J A
JA
Schlack
S C
SC
Harms
B A
BA
Jacoby
R F
RF
D002648:Child; D004564:Electrocoagulation; D006801:Humans; D007078:Ileal Neoplasms / Q000209:etiology* / Q000601:surgery; D008297:Male; D011127:Polyps / Q000601:surgery*; D011230:Precancerous Conditions / Q000601:surgery*; D016737:Proctocolectomy, Restorative / Q000009:adverse effects*; D012004:Rectal Neoplasms / Q000601:surgery*; D012008:Recurrence