title: NF00659A1, A2, A3, B1 and B2, novel antitumor antibiotics produced by Aspergillus sp. NF 00659. II. Structural elucidation.
abstract: NF00659A1, A2, A3, B1 and B2, having insecticidal and antitumor activities, were isolated from a culture mycelium of Aspergillus sp. NF 00659. The novel structure of NF00659s were determined mainly by spectroscopic studies including various NMR measurements. NF00659s have a common structure which consists of acyl, alpha-pyrone and 4,5-seco-tricyclic diterpene moieties.
authors.affiliation: Applied Microbiology Research Center, Nippon Kayaku Co., Ltd., Saitama, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Suzuki
authors.forename: A
authors.initials: A
authors.lastname: Kuwahara
authors.forename: T
authors.initials: T
authors.lastname: Nishikiori
authors.forename: T
authors.initials: T
authors.lastname: Nakagawa
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000737:chemistry*; D004224:Diterpenes / Q000737:chemistry*; D007306:Insecticides / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D011753:Pyrones / Q000737:chemistry*
chemical_list: D000903:Antibiotics, Antineoplastic; D004224:Diterpenes; D007306:Insecticides; D011753:Pyrones