title: Probing tumor microvascularity by measurement, analysis and display of contrast agent uptake kinetics.
abstract: This paper describes a measurement protocol for acquiring quantitative dynamic MRI data and novel analysis and display software (Magnetic Resonance Imaging Workbench (MRIW)). Proton density-weighted and T1-weighted two-dimensional gradient echo images are used to quantify tissue contrast agent concentration. The dynamic studies last approximately 7 minutes, with 10-second temporal resolution. Analyses of signal and concentration changes with time are performed, allowing capillary permeability-surface area product, tissue leakage space, enhancement onset time, mean enhancement gradient and maximum enhancement level to be mapped as false-color parametric overlays registered with anatomic images. Quantification of permeability and leakage space provides a method for comparing physiology in patients between visits or for intersite comparisons.
authors.affiliation: Cancer Research Campaign Clinical Magnetic Resonance Research Group, Institute of Cancer Research, Sutton, Surrey, United Kingdom. g.parker@ion.ucl.ac.uk
authors.forename: G J
authors.initials: GJ
authors.lastname: Parker
authors.forename: J
authors.initials: J
authors.lastname: Suckling
authors.forename: S F
authors.initials: SF
authors.lastname: Tanner
authors.forename: A R
authors.initials: AR
authors.lastname: Padhani
authors.forename: P B
authors.initials: PB
authors.lastname: Revell
authors.forename: J E
authors.initials: JE
authors.lastname: Husband
authors.forename: M O
authors.initials: MO
authors.lastname: Leach
mesh_terms: D001254:Astrocytoma / Q000098:blood supply* / Q000175:diagnosis; D001932:Brain Neoplasms / Q000098:blood supply* / Q000175:diagnosis; D003196:Computer Graphics; D003287:Contrast Media / Q000008:administration & dosage / Q000493:pharmacokinetics*; D003937:Diagnosis, Differential; D017352:Echo-Planar Imaging / Q000379:methods*; D019786:Gadolinium DTPA; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D008297:Male; D008833:Microcirculation / Q000502:physiology; D008962:Models, Theoretical; D009942:Organometallic Compounds / Q000008:administration & dosage / Q000493:pharmacokinetics*; D004369:Pentetic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D011471:Prostatic Neoplasms / Q000098:blood supply* / Q000175:diagnosis; D012680:Sensitivity and Specificity; D012984:Software
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; D004369:Pentetic Acid; D019786:Gadolinium DTPA