Heat-shock-proteins-antibodies in patients with Helicobacter pylori associated chronic gastritis.
Twenty eight patients (15 F, 13 M mean age 37.7 SD +/- 9.93 range 22-55) affected by Helicobacter Pylori infection associated gastritis were studied. HSP 70 Antibodies were found in 21.4% of patients and their mean values were significantly higher in the patients than in the subjects affected by gastritis HP negative used as controls (p = 0.05). This datum was confirmed by Western blotting. The presence of HSP 70 antibodies in the sera of those patients may support the link between the protein and the development and persistence of chronic inflammation in the gastric mucosa.
Leri
O
O
Department of Tropical and Infectious Diseases, University La Sapienza, Rome, Italy.
Teichner
A
A
Sinopoli
M T
MT
Abbolito
M R
MR
Pustorino
R
R
Nicosia
R
R
Paparo Barbaro
S
S
D000328:Adult; D000906:Antibodies / Q000032:analysis*; D002908:Chronic Disease; D005260:Female; D005756:Gastritis / Q000276:immunology* / Q000382:microbiology; D018840:HSP70 Heat-Shock Proteins / Q000276:immunology*; D016481:Helicobacter Infections / Q000276:immunology* / Q000382:microbiology; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D008875:Middle Aged
D000906:Antibodies; D018840:HSP70 Heat-Shock Proteins