Effects of powder on infection risks and associated mechanisms.
This paper examines the release of Tumour necrosis factor alpha, (TNFa) interleukin 1, eicosanoids, and hydrogen peroxide from macrophages exposed to glove starch particles. Studies are described which show that T-cell responses are potently activated by glove powder products leading to the release and formation of high amounts of pro-inflammatory mediators, ultimately resulting in adverse clinical consequences such as starch peritonitis or adhesions.
Renz
H
H
Laboratory Medicine and Immunopathology, Humboldt University of Berlin, Germany.
Gemsa
D
D
D000818:Animals; D001424:Bacterial Infections / Q000209:etiology*; D002465:Cell Movement; D002478:Cells, Cultured; D015777:Eicosanoids / Q000378:metabolism; D005932:Gloves, Surgical; D015745:Granuloma, Foreign-Body / Q000209:etiology; D006801:Humans; D006861:Hydrogen Peroxide / Q000378:metabolism; D007111:Immunity, Cellular / Q000187:drug effects*; D018836:Inflammation Mediators / Q000276:immunology / Q000378:metabolism; D007375:Interleukin-1 / Q000276:immunology; D008213:Lymphocyte Activation / Q000187:drug effects / Q000276:immunology; D008262:Macrophage Activation / Q000187:drug effects / Q000276:immunology; D017737:Macrophages, Peritoneal / Q000187:drug effects / Q000276:immunology; D010529:Peritoneal Cavity; D010532:Peritoneal Diseases / Q000209:etiology / Q000276:immunology; D010538:Peritonitis / Q000209:etiology / Q000276:immunology; D011208:Powders / Q000009:adverse effects; D051381:Rats; D012307:Risk Factors; D013213:Starch / Q000009:adverse effects*; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology; D000267:Tissue Adhesions / Q000209:etiology / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology
D015777:Eicosanoids; D018836:Inflammation Mediators; D007375:Interleukin-1; D011208:Powders; D014409:Tumor Necrosis Factor-alpha; D013213:Starch; D006861:Hydrogen Peroxide