Manipulation of alcohol drinking by liver transplantation.
The procedure of liver transplantation in alcoholic liver disease raises the question whether it would be possible to regulate the recipient's future drinking by the choice of donor liver. To address this question, we conducted transplantations with rat lines selected for high (AA) and low (ANA) alcohol preference. AA recipients having alcohol experience before the operation remained heavy drinkers regardless of whether the graft came from an AA or ANA donor. However, in these AA recipients who started drinking only after the operation, differences emerged, with AA grafts creating heavy drinking and ANA donor livers resulting in very low drinking. An overall increase in the acetaldehyde levels was introduced by the ANA livers, thus reflecting the original line differences. Similarly, in subsequent experiments, it was observed that when the aldehyde dehydrogenase inhibitor calcium carbimide was introduced in different amounts to the diet, alcohol drinking was reduced more in animals not used to drinking. The magnitude of this effect, especially in situations with established heavy drinking, is of relevance in future contemplations about liver transplantations between humans with different aldehyde dehydrogenase genotypes.
Eriksson
C J
CJ
Department of Mental Health and Alcohol Research, National Public Health Institute, Helsinki, Finland.
Koivisto
T
T
Sriwatanawongsa
V
V
Martelius
T
T
Mäkisalo
H
H
Höckerstedt
K
K
D000079:Acetaldehyde / Q000097:blood; D000428:Alcohol Drinking / Q000235:genetics* / Q000503:physiopathology; D000437:Alcoholism / Q000235:genetics* / Q000503:physiopathology; D000444:Aldehyde Dehydrogenase / Q000172:deficiency / Q000235:genetics; D000818:Animals; D000431:Ethanol / Q000493:pharmacokinetics; D008104:Liver Cirrhosis, Alcoholic / Q000235:genetics / Q000503:physiopathology; D016031:Liver Transplantation / Q000502:physiology*; D009154:Mutation; D051381:Rats; D011919:Rats, Inbred Strains
D000431:Ethanol; D000444:Aldehyde Dehydrogenase; D000079:Acetaldehyde