title: Percutaneous large core needle biopsy versus surgical biopsy in the diagnosis of breast lesions.
abstract: OBJECTIVE
  To value LCNB accuracy in the determination of morphobiological parameters and as an alternative to the open SB diagnostic procedure of breast lesions.
  
  
  METHODS
  University Hospital, Italy.
  
  
  METHODS
  From May 1992 to February 1995 196 biopsies have been performed. The diameter of the neoplasms examined varied from 0.6 to 7 cm with an average of 1.9 cm.
  
  
  METHODS
  The accuracy of the two methods in the evaluation of histological degree, receptor state, protein c-erb B2 and p53 were compared.
  
  
  RESULTS
  No inadequate sampling were ever recorded. LCNB has shown values of 97% sensitivity and 100% specificity. The positivity and negativity predicted values obtained were 100% and 89% respectively. Retrospectively 70 sample-cases of carcinoma were selected and the morphobiological parameters evaluated. The correlation coefficients for the data obtained with SB and LCNB in the evaluation of Progesteron and Oestrogen receptor expression, protein c-erb B2 and p53 were excellent. Furthermore it was noted that LCNB allows a saving of at least 1/3 of the cost vs intraoperative SB.
  
  
  CONCLUSIONS
  Percutaneous LCNB has high diagnostic accuracy for histological classification. LCNB has the same accuracy as SB for morphobiological parameters. The cost of LCNB is markedly lower than SB.
authors.affiliation: Department of General Surgery, Medical School, University of Udine, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Anania
authors.forename: M
authors.initials: M
authors.lastname: Bazzocchi
authors.forename: C
authors.initials: C
authors.lastname: di Loreto
authors.forename: A
authors.initials: A
authors.lastname: Risaliti
authors.forename: G
authors.initials: G
authors.lastname: Terrosu
authors.forename: A
authors.initials: A
authors.lastname: Donini
authors.forename: C
authors.initials: C
authors.lastname: Zuiani
authors.forename: F
authors.initials: F
authors.lastname: Puglisi
authors.forename: F
authors.initials: F
authors.lastname: Bresadola
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy / Q000191:economics / Q000379:methods*; D001707:Biopsy, Needle / Q000191:economics / Q000379:methods*; D001943:Breast Neoplasms / Q000737:chemistry / Q000473:pathology*; D003362:Cost-Benefit Analysis; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests
chemical_list: D014408:Biomarkers, Tumor