title: Functional magnetic resonance imaging of median nerve stimulation in rats at 2.0 T.
abstract: An animal model of sensory activation using fMRI at 2.0 T has been developed, demonstrating that fMRI studies on animals need not be limited to high field magnets. These methods produced reliable image intensity changes of 2% using median nerve stimulation in rats at 3 Hz and propofol as the anesthetic agent. At 6 Hz the activation was slightly but not statistically significantly greater. The feasibility of fMRI studies in animals using propofol suggests that it may be a useful anesthetic for fMRI studies in agitated adult patients or in children.
authors.affiliation: Department of Psychiatry, West Haven VAMC, CT 06516, USA.
authors.forename: B E
authors.initials: BE
authors.lastname: Scanley
authors.forename: R P
authors.initials: RP
authors.lastname: Kennan
authors.forename: S
authors.initials: S
authors.lastname: Cannan
authors.forename: P
authors.initials: P
authors.lastname: Skudlarski
authors.forename: R B
authors.initials: RB
authors.lastname: Innis
authors.forename: J C
authors.initials: JC
authors.lastname: Gore
mesh_terms: D018686:Anesthetics, Intravenous / Q000494:pharmacology; D000818:Animals; D004558:Electric Stimulation; D005260:Female; D006993:Hypnotics and Sedatives / Q000494:pharmacology; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008475:Median Nerve / Q000187:drug effects / Q000502:physiology*; D015742:Propofol / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013003:Somatosensory Cortex / Q000502:physiology
chemical_list: D018686:Anesthetics, Intravenous; D006993:Hypnotics and Sedatives; D015742:Propofol