title: The frequency of autoantibodies in Turkish patients with lupus nephritis.
abstract: We analysed the frequency of autoantibodies in 44 patients with lupus nephritis. Antinuclear antibody (ANA) was found in 91% of patients by an indirect immunofluorescence technique on HEp-2 cells at the time of study. Anti-dsDNA antibodies were found at high levels in most of the patients using the SynELISA test, which reveals both high and low avidity antibodies, but only in 64% of patients using the DAKO assay, which reveals high avidity antibodies. Anti-histone antibodies were found in 52% of the patients. Anti-SSA/Ro antibodies were positive in 27% of all patients; these patients also had prominent cutaneous involvement and photosensitivity. The frequency of anti-SSB/La and Anti-Sm antibodies was 7%. Immunoblotting experiments confirmed the findings shown by the techniques described above, and anti-ribosomal antibodies were found to be positive in more cases by the latter assay. IgA rheumatoid factor (RF) was more frequent (20.4%) than IgM RF (9.9%). In conclusion, Turkish patients suffering from lupus nephritis seem to express a total autoantibody profile similar to that reported for systemic lupus erythematosus from other parts of Europe.
authors.affiliation: Department of Immunology, Faculty of Medicine, Ankara University, Turkey.
authors.forename: N
authors.initials: N
authors.lastname: Düzgün
authors.forename: M
authors.initials: M
authors.lastname: Hoier-Madsen
authors.forename: A
authors.initials: A
authors.lastname: Wiik
authors.forename: G
authors.initials: G
authors.lastname: Tokgöz
mesh_terms: D000293:Adolescent; D000328:Adult; D000974:Antibodies, Antinuclear / Q000097:blood*; D001323:Autoantibodies / Q000097:blood*; D005260:Female; D006801:Humans; D008181:Lupus Nephritis / Q000097:blood / Q000453:epidemiology / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D014421:Turkey / Q000453:epidemiology
chemical_list: D000974:Antibodies, Antinuclear; D001323:Autoantibodies