Studies on Alismatis rhizoma. I. Anti-allergic effects of methanol extract and six terpene components from Alismatis rhizoma (dried rhizome of Alisma orientale).
Methanol and aqueous extracts (TMe-ext and TAq-ext) from dried rhizomes of Alisma orientale have been screened for activity in experimental models of type I-IV allergies. In the type III allergic model, TMe-ext at oral doses of 50, 200 mg/kg showed an inhibitory effect on the direct passive Arthus reaction (DPAR) in rats, while TAq-ext did not. Four triterpenes (alisol A, alisol B, alisol A monoacetate and alisol B monoacetate) and two sesquiterpenes (alismol and alismoxide) isolated from TMe-ext also exhibited this inhibitory effect. In a type I allergic model, TMe-ext inhibited 48-h homologous passive cutaneous anaphylaxis (PCA) in rats. In a type II allergic model, it was found that TMe-ext inhibits reversed cutaneous anaphylaxis (RCA) in rats. Furthermore, in a type IV allergic model, TMe-ext had an inhibitory effect on the induction phase in picryl chloride-induced contact dermatitis (PC-CD) in mice. These results indicate that Alismatis Rhizoma not only inhibits antibody-mediated allergic reactions but also influences cell reactions and should be recognized as a material for the treatment of allergic reactions, and the anti-type III allergic components are partially attributable to the terpenes mentioned above.
Kubo
M
M
Faculty of Pharmaceutical Sciences, Kinki University, Higashiosaka, Osaka, Japan.
Matsuda
H
H
Tomohiro
N
N
Yoshikawa
M
M
D000818:Animals; D018926:Anti-Allergic Agents / Q000494:pharmacology*; D001183:Arthus Reaction / Q000517:prevention & control; D017449:Dermatitis, Allergic Contact / Q000517:prevention & control; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D006967:Hypersensitivity / Q000517:prevention & control*; D008297:Male; D000432:Methanol; D051379:Mice; D008813:Mice, Inbred ICR; D010323:Passive Cutaneous Anaphylaxis / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D017208:Rats, Wistar; D013729:Terpenes / Q000302:isolation & purification / Q000494:pharmacology*
D018926:Anti-Allergic Agents; D004365:Drugs, Chinese Herbal; D013729:Terpenes; D000432:Methanol