title: Pharmacological characterization of synaptic transmission through mGluRs in rat cerebellar slices.
abstract: The mGluR-mediated EPSP at parallel fibre-Purkinje cell synapses in the cerebellum was blocked concentration-dependently and reversibly by antagonists acting selectively on group-I mGluRs but not by an inhibitor of group-III receptors. The results provide pharmacological evidence that the receptor type responsible for the mGluR-EPSP is mGluR1.
authors.affiliation: The Cruciform Project, University College London, U.K.
authors.forename: A M
authors.initials: AM
authors.lastname: Batchelor
authors.forename: T
authors.initials: T
authors.lastname: Knöpfel
authors.forename: F
authors.initials: F
authors.lastname: Gasparini
authors.forename: J
authors.initials: J
authors.lastname: Garthwaite
mesh_terms: D000818:Animals; D001565:Benzoates / Q000494:pharmacology*; D002531:Cerebellum / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology*; D005998:Glycine / Q000031:analogs & derivatives* / Q000494:pharmacology; D051381:Rats; D018094:Receptors, Metabotropic Glutamate / Q000187:drug effects*; D009435:Synaptic Transmission / Q000187:drug effects*
chemical_list: D001565:Benzoates; D018691:Excitatory Amino Acid Antagonists; D018094:Receptors, Metabotropic Glutamate; C079693:4-carboxyphenylglycine; D005998:Glycine