Human CD30+ cells are induced by Mycobacterium tuberculosis and present in tuberculosis lesions.
CD30 is a member of the tumor necrosis factor/nerve growth factor receptor family and evidence has been presented that activated CD4+ CD45Ro+ T cells of Th2 type selectively express CD30. Mycobacterium tuberculosis, a facultative intracellular bacterium capable of replicating in resting macrophages, is a potent inducer of IFN-gamma secretion by Th1 cells. We find increased CD30 expression by M. tuberculosis-stimulated alpha beta and gamma delta T cells, and elevated numbers of CD30+ alpha beta T cells in tuberculosis pleuritis and affected lung tissue. Furthermore, surface CD30 was associated with intracytoplasmic IFN-gamma expression and IFN-gamma production by M. tuberculosis-stimulated alpha beta and gamma delta T cells. Thus, our results indicate that M. tuberculosis is a potent inducer of CD30 expression in Th1 cells and argue against exclusive correlation of CD30 expression with Th2 cell responses.
Munk
M E
ME
Department of Immunology, University of Ulm, Germany.
Kern
P
P
Kaufmann
S H
SH
D000818:Animals; D002465:Cell Movement / Q000276:immunology; D002478:Cells, Cultured; D003593:Cytoplasm / Q000276:immunology / Q000378:metabolism; D004446:Echinococcus / Q000276:immunology; D006801:Humans; D007371:Interferon-gamma / Q000096:biosynthesis; D017730:Ki-1 Antigen / Q000096:biosynthesis / Q000276:immunology*; D007700:Kinetics; D008168:Lung / Q000473:pathology; D008213:Lymphocyte Activation; D009169:Mycobacterium tuberculosis / Q000276:immunology*; D016176:T-Lymphocyte Subsets / Q000276:immunology* / Q000378:metabolism; D018417:Th1 Cells / Q000276:immunology / Q000378:metabolism; D014376:Tuberculosis / Q000276:immunology* / Q000473:pathology*
D017730:Ki-1 Antigen; D007371:Interferon-gamma