title: Porous high-density polyethylene implants in auricular reconstruction.
abstract: OBJECTIVE
  To evaluate the ability of porous high-density polyethylene (Medpor) implants to tolerate exposure and support skin grafts when used to reconstruct defects in auricular cartilage in an animal model.
  
  
  METHODS
  Polyethylene implants placed in surgically created defects in auricular cartilage and covered with a skin flap were then exposed at either 4, 7, or 21 days after implantation. The exposed implants were then allowed to heal secondarily or received a skin graft 1 week later. The ability of polyethylene implants to tolerate exposure and support skin grafts was observed clinically and via histological study of the implantation sites.
  
  
  METHODS
  Nine adult New Zealand rabbits.
  
  
  RESULTS
  Polyethylene implants demonstrated excellent ability to tolerate wound exposure as early as 4 days after implantation, with extrusion of 1 of the 36 implants placed. The degree of secondary wound healing increased as the interval from implantation to exposure increased from 4 to 21 days. Exposed polyethylene implants in all groups also supported all 18 skin grafts placed 1 week after exposure of the implant surface.
  
  
  CONCLUSIONS
  Polyethylene implants are well tolerated as replacements for native cartilage in auricular reconstruction. Polyethylene implants tolerated wound exposure as early as 4 days after implantation and demonstrated the ability to heal by secondary intention and support skin grafts. This is likely because of the extent of fibrovascular ingrowth from surrounding tissue, which allows the material to behave more like native tissue and less like a foreign body in this setting.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, New York Eye and Ear Infirmary, NY, USA.
authors.forename: J D
authors.initials: JD
authors.lastname: Williams
authors.forename: T
authors.initials: T
authors.lastname: Romo
authors.forename: A P
authors.initials: AP
authors.lastname: Sclafani
authors.forename: H
authors.initials: H
authors.lastname: Cho
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D004425:Ear Cartilage / Q000601:surgery*; D011095:Polyethylenes; D016062:Porosity; D019736:Prostheses and Implants; D011817:Rabbits; D016038:Skin Transplantation; D013524:Surgical Flaps; D013997:Time Factors; D014945:Wound Healing
chemical_list: D001672:Biocompatible Materials; C084562:Medpor; D011095:Polyethylenes