title: Novel conformationally extended naphthalene-based inhibitors of farnesyltransferase.
authors.affiliation: Rhône-Poulenc Rorer S.A., Centre de Recherches de Vitry-Alfortville, Vitry-sur-Seine, France. burnscj@rpr.rpna.com
authors.forename: C J
authors.initials: CJ
authors.lastname: Burns
authors.forename: J D
authors.initials: JD
authors.lastname: Guitton
authors.forename: B
authors.initials: B
authors.lastname: Baudoin
authors.forename: Y
authors.initials: Y
authors.lastname: Lelièvre
authors.forename: M
authors.initials: M
authors.lastname: Duchesne
authors.forename: F
authors.initials: F
authors.lastname: Parker
authors.forename: N
authors.initials: N
authors.lastname: Fromage
authors.forename: A
authors.initials: A
authors.lastname: Commerçon
mesh_terms: D015081:2-Naphthylamine / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D019883:Alkyl and Aryl Transferases; D000595:Amino Acid Sequence; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D002461:Cell Line, Transformed; D003545:Cysteine / Q000737:chemistry; D004151:Dipeptides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D051231:Farnesyltranstransferase; D011905:Genes, ras; D008715:Methionine / Q000737:chemistry; D008958:Models, Molecular; D015394:Molecular Structure; D009281:Naphthalenes / Q000737:chemistry*; D011487:Protein Conformation; D013329:Structure-Activity Relationship; D014166:Transferases / Q000037:antagonists & inhibitors*; D014407:Tumor Cells, Cultured; D018631:ras Proteins / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D004151:Dipeptides; D004791:Enzyme Inhibitors; D009281:Naphthalenes; C106582:RPR 114334; C031721:naphthalene; D008715:Methionine; D015081:2-Naphthylamine; D014166:Transferases; D019883:Alkyl and Aryl Transferases; D051231:Farnesyltranstransferase; D018631:ras Proteins; D003545:Cysteine