[The toxicological characteristics of Gastrofenzin. II. Its subacute oral toxicity].
The subacute (30 day) oral toxicity of Gastrofenzin has been investigated in white rats "Wistar" of both sexes, treated with 0.7 and 33 mg.kg-1 for the male and 0.9 and 44 mg.kg-1 for the female rats. The applied doses respond respectively to the control doses, 1/100 and 1/20 LD50 of the preparation. A complex of integral, behaviour, laboratory biochemical and histological methods has been used. The findings show that Gastrofenzin in doses 1/100 and 1/20 LD50 does not exert cumulative effect, reported by the lack of lethal effect among the animals. With the help of actograph "AIDA" an increased spontaneous activity is reported in the rats from both sexes treated with dose 1/20 LD50 of the preparation. Under the experimental conditions the doses of 7 and 9 mg.kg-1 (1/100 LD50) and 33 and 44 mg.kg-1 (1/20 LD50) do not exert toxic effect on the liver, kidneys and brain. Deviations are observed which show increasing of the oxidative-metabolic processes and trigger adaptation mechanisms in the above mentioned organs.
Mikhaĭlova
A
A
Antov
G
G
Khalkova
Zh
Zh
Zaĭkov
Kh
Kh
Tasheva
M
M
Dinoeva
S
S
D000284:Administration, Oral; D000818:Animals; D000897:Anti-Ulcer Agents / Q000008:administration & dosage / Q000633:toxicity*; D000928:Antidepressive Agents / Q000008:administration & dosage / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D005260:Female; D007546:Isoquinolines / Q000008:administration & dosage / Q000633:toxicity*; D007928:Lethal Dose 50; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D010084:Oxidation-Reduction / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D044005:Tetrahydroisoquinolines
D000897:Anti-Ulcer Agents; D000928:Antidepressive Agents; D007546:Isoquinolines; D044005:Tetrahydroisoquinolines; C068492:gastrofenzin