title: Biological activity of purpurogallin.
abstract: Purpurogallin showed antibacterial activity toward gram-positive bacteria. Strong activity against methicillin-resistant Staphylococcus aureus [minimal inhibitory concentration (MIC) against methicillin of 1600 micrograms/ml] was found, with MIC of 11.0 micrograms/ml. Purpurogallin inhibited the growth of all tested plants and decreased the chlorophyll content in the cotyledons of Brassica campestris subsp. rapa. It showed potent inhibitory activity against prolyl endopeptidase (the 50% inhibitory concentration was 1.6 x 10(-5) M), unlike its analogues, hinokitiol and tropolone.
authors.affiliation: Osaka University of Pharmaceutical Sciences, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Inamori
authors.forename: C
authors.initials: C
authors.lastname: Muro
authors.forename: E
authors.initials: E
authors.lastname: Sajima
authors.forename: M
authors.initials: M
authors.lastname: Katagiri
authors.forename: Y
authors.initials: Y
authors.lastname: Okamoto
authors.forename: H
authors.initials: H
authors.lastname: Tanaka
authors.forename: Y
authors.initials: Y
authors.lastname: Sakagami
authors.forename: H
authors.initials: H
authors.lastname: Tsujibo
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001567:Benzocycloheptenes / Q000494:pharmacology*; D001937:Brassica / Q000187:drug effects* / Q000254:growth & development; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D039821:Monoterpenes; D000085822:Prolyl Oligopeptidases; D012697:Serine Endopeptidases / Q000187:drug effects; D015842:Serine Proteinase Inhibitors / Q000494:pharmacology*; D014334:Tropolone / Q000031:analogs & derivatives / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D001567:Benzocycloheptenes; D039821:Monoterpenes; D015842:Serine Proteinase Inhibitors; D014334:Tropolone; D012697:Serine Endopeptidases; D000085822:Prolyl Oligopeptidases; C026133:purpurogallin; C009479:beta-thujaplicin