title: Analysis of cancer mortality among atomic bomb survivors registered at Hiroshima University.
abstract: The aim of this study was to investigate the late effect on cancer mortality risk of the radiation exposure of atomic bomb survivors who comprised a study population different from that previously studied by the Radiation Effects Research Foundation (RERF). We examined survivors residing in Hiroshima Prefecture, who were followed up between 1968 and 1989 by the Research Institute for Radiation Biology and Medicine (RIRBM) at Hiroshima University. We used the dose-evaluation system known as Atomic Bomb Survivors 1993 Dose (ABS93D), which was based on the Dosimetry System 1986 for the survivors registered with RERF. The dose estimation was applied in a total of 35,123 subjects. Among survivors who had been alive for > 20 years after the bombing, the relative mortality risk of leukaemia at 1 Gy of organ dose was 2.37 (90% confidence interval: 1.36-3.39), which was significantly higher than the zero dose control group. Similarly, significantly higher risks were observed for all cancers except leukaemia, including cancers of the lung, colon and female breast. Comparison is made with RERF results regarding temporal changes in the relative risk. Although we observed slightly lower relative risks than RERF values for the cancer of the stomach and lung, and for all cancer except leukaemia, no marked trends for any cancer were observed in this study. Though there were some differences in population between RERF and RIRBM, no marked discrepancies were observed.
authors.affiliation: Research Institute for Radiation Biology and Medicine, Hiroshima University, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Matsuura
authors.forename: M
authors.initials: M
authors.lastname: Hoshi
authors.forename: N
authors.initials: N
authors.lastname: Hayakawa
authors.forename: H
authors.initials: H
authors.lastname: Shimokata
authors.forename: M
authors.initials: M
authors.lastname: Ohtaki
authors.forename: M
authors.initials: M
authors.lastname: Ikeuchi
authors.forename: F
authors.initials: F
authors.lastname: Kasagi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D004307:Dose-Response Relationship, Radiation; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007564:Japan; D008297:Male; D008875:Middle Aged; D009381:Neoplasms, Radiation-Induced / Q000401:mortality*; D009689:Nuclear Warfare; D012306:Risk