title: Factors controlling the turnover of T memory cells.
abstract: Most of the T cells participating in the primary immune response are rapidly eliminated, but small numbers of these cells survive and differentiate into long-lived memory cells. Information on the life history of memory cells can be obtained by studying the component of memory-phenotype T cells found in normal animals; these cells are presumed to represent memory cells specific for various environmental antigens. For CD8+ cells, in vivo exposure to viruses and certain other infectious agents causes a large proportion of memory-phenotype (CD44hi) cells to enter the cell cycle. In this situation, stimulation of CD44hi CD8+ cells does not seem to require T-cell receptor ligation and appears to reflect release of various cytokines, especially type I interferon. The capacity of infectious agents to induce non-antigen-specific stimulation of T cells may play a role in boosting the survival of memory cells and perhaps also in providing an adjuvant function during the primary response.
authors.affiliation: Department of Immunology, Scripps Research Institute, La Jolla, California 92037, USA. jsprent@scripps.edu
authors.forename: J
authors.initials: J
authors.lastname: Sprent
authors.forename: D F
authors.initials: DF
authors.lastname: Tough
authors.forename: S
authors.initials: S
authors.lastname: Sun
mesh_terms: D000818:Animals; D000941:Antigens / Q000276:immunology; D006801:Humans; D007156:Immunologic Memory / Q000276:immunology*; D008213:Lymphocyte Activation / Q000276:immunology; D011948:Receptors, Antigen, T-Cell / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D000941:Antigens; D011948:Receptors, Antigen, T-Cell