title: Similar serovar and drug susceptibility profiles among AIDS-related Mycobacterium avium isolates from diverse geographic locations.
abstract: Serotyping was performed on Mycobacterium avium isolates from 40 AIDS patients from 5 geographic sites: Boston (17 patients), New Hampshire (4 patients), Finland (12 patients), Trinidad (3 patients), and Kenya (4 patients). Serovars were similar from the five sites. Serovars 4 and 8 were the most common. In addition, minimal inhibitory concentrations to 8 antimicrobial agents were determined for 31 of these isolates and for 21 additional patient isolates from these sites. Minimal inhibitory concentration90 values for clarithromycin, azithromycin, clofazimine, amikacin, ethambutol, ciprofloxacin, sparfloxacin, and rifabutin were similar for isolates from the five geographic sites. Antimicrobial susceptibility patterns did not differ by serovar.
authors.affiliation: Department of Microbiology, Dartmouth Medical School, Hanover, NH 03755-3842, USA. Nicholas.Jacobs@Dartmouth.edu
authors.forename: N J
authors.initials: NJ
authors.lastname: Jacobs
authors.forename: C
authors.initials: C
authors.lastname: Fordham Von Reyn
authors.forename: N
authors.initials: N
authors.lastname: Gine
authors.forename: D
authors.initials: D
authors.lastname: Dawson
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000097:blood / Q000188:drug therapy / Q000382:microbiology*; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D018791:CD4 Lymphocyte Count; D005243:Feces / Q000382:microbiology; D005843:Geography; D006801:Humans; D008826:Microbial Sensitivity Tests; D015269:Mycobacterium avium Complex / Q000145:classification* / Q000187:drug effects / Q000302:isolation & purification; D015270:Mycobacterium avium-intracellulare Infection / Q000188:drug therapy / Q000382:microbiology*; D012703:Serotyping; D013183:Sputum / Q000382:microbiology
chemical_list: D000900:Anti-Bacterial Agents