Influence of N-acetylcysteine on the formation of biofilm by Staphylococcus epidermidis.
The influence of various concentrations (0.003-8 mg/mL) of N-acetylcysteine on the formation of biofilms by 15 strains of Staphylococcus epidermidis has been studied. A dose-related decrease in biofilm formation was observed, except with the lowest concentrations. The 'slime' index relative to the control was 63%, 55%, 46%, 34%, 26% and 26% in the presence of 0.25, 0.5, 1, 2, 4, and 8 mg/mL of N-acetylcysteine, respectively. These data are statistically significant. The inhibitory effect of 2 mg/mL of N-acetylcysteine on slime formation was also verified by electron microscopy.
Pérez-Giraldo
C
C
Department of Microbiology, Faculty of Medicine, Extremadura University, Badajoz, Spain.
Rodríguez-Benito
A
A
Morán
F J
FJ
Hurtado
C
C
Blanco
M T
MT
Gómez-García
A C
AC
D000111:Acetylcysteine / Q000494:pharmacology*; D001422:Bacterial Adhesion / Q000187:drug effects; D018441:Biofilms / Q000254:growth & development*; D013212:Staphylococcus epidermidis / Q000187:drug effects* / Q000502:physiology
D000111:Acetylcysteine