title: Langerhans' cell granuloma confined to the bile duct.
abstract: Langerhans' cell histiocytosis (LCH) of the liver is uncommon. When seen, it is part of multifocal disease and can present as biliary obstruction. We present a case of sclerosing biliary disease with a solitary LCH lesion and no evidence of systemic disease. We postulate that the LCH is a secondary phenomenon, arising against a background of a complex, familial liver disease. This case also raises the possibility that some instances of idiopathic sclerosing cholangitis may follow cryptic LCH of the bile ducts.
authors.affiliation: Department of Pathology, Children's Hopital of Philadelphia, Pennsylvania, USA.
authors.forename: L S
authors.initials: LS
authors.lastname: Finn
authors.forename: R
authors.initials: R
authors.lastname: Jaffe
mesh_terms: D001649:Bile Duct Diseases / Q000209:etiology / Q000473:pathology*; D017734:Bile Ducts, Extrahepatic / Q000473:pathology; D002675:Child, Preschool; D005260:Female; D006646:Histiocytosis, Langerhans-Cell / Q000209:etiology / Q000473:pathology*; D006801:Humans; D006975:Hypertension, Portal / Q000473:pathology / Q000601:surgery; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007565:Jaundice / Q000473:pathology / Q000601:surgery; D008099:Liver / Q000473:pathology; D008107:Liver Diseases / Q000150:complications / Q000235:genetics / Q000601:surgery; D016031:Liver Transplantation
chemical_list: D007166:Immunosuppressive Agents