The efficacy of ivermectin against laboratory strains of Heligmosomoides polygyrus (Nematoda).
A susceptible strain of Heligmosomoides polygyrus was selected for 15 generations with increasing doses of ivermectin (0-6 mg/kg). A passage strain was developed, parallel with the ivermectin-selected strain, to control for changes due to rapid passage from mouse to mouse. The LD50s of the 8th and 15th generations of the ivermectin-selected strain were 1.5 times that of the susceptible strain. The LD50 of the passage strain at generations 8 and 15 remained similar to that of the susceptible strain. Ivermectin efficacy was lower against the LA stage than against the adult stage in the susceptible strain, the Ivermectin-selected strain and the passage strain at generation 8.
Njoroge
J M
JM
Institute of Parasitology, Macdonald Campus of McGill University, Ste-Anne-De-Bellevue, Quebec, Canada.
Scott
M E
ME
Jalili
F
F
D000818:Animals; D000969:Antinematodal Agents / Q000494:pharmacology*; D004195:Disease Models, Animal; D005260:Female; D007559:Ivermectin / Q000494:pharmacology*; D051379:Mice; D009351:Nematospiroides dubius / Q000187:drug effects* / Q000472:pathogenicity; D012692:Serial Passage; D017206:Strongylida Infections / Q000188:drug therapy* / Q000469:parasitology
D000969:Antinematodal Agents; D007559:Ivermectin