Ocular blood flow in experimental glaucoma: a study in cynomolgus monkeys.
Experimental glaucoma was induced in 1 eye of 6 cynomolgus monkeys by laser treatment of the trabecular meshwork. In 5 of the 6 monkeys the increased intraocular pressure (IOP) caused marked glaucomatous damage in the experimental eye. Ocular blood flow was determined with labeled microspheres 4 years after the laser treatment. IOP was regulated with an external reservoir. With the same perfusion pressure in both eyes no statistically significant difference was observed between the 2 eyes for total ocular blood flow or for blood flow through any of the ocular tissues. Total ocular blood flow was 343.5 +/- 61.4 mg/min (mean +/- SEM) in the control eye and 385.3 +/- 107.7 mg/min in the experimental eye.
Alm
A
A
Department of Ophthalmology, University Hospital, Uppsala, Sweden. albert.alm@ogon.uas.se
Lambrou
G N
GN
Mäepea
O
O
Nilsson
S F
SF
Percicot
C
C
D000818:Animals; D001783:Blood Flow Velocity / Q000502:physiology*; D004195:Disease Models, Animal; D005123:Eye / Q000098:blood supply*; D005260:Female; D005901:Glaucoma / Q000209:etiology / Q000473:pathology / Q000503:physiopathology*; D007429:Intraocular Pressure; D007498:Iris / Q000098:blood supply; D007834:Lasers; D008252:Macaca fascicularis; D008297:Male; D008863:Microspheres; D009900:Optic Nerve / Q000473:pathology; D014129:Trabecular Meshwork / Q000293:injuries / Q000503:physiopathology