Immunogenic and protective properties of haemagglutinin protein (H) of rinderpest virus expressed by a recombinant baculovirus.
The hemagglutinin (H) protein of Rinderpest virus expressed by a recombinant baculovirus used as a vaccine produced high titres of neutralizing antibody to Rinderpest virus in the vaccinated cattle, comparable to the levels produced by live attenuated vaccine. The immunized cattle were protected against a vaccine-virus challenge, as demonstrated by the failure of development of antibodies to N protein of the vaccine virus. The lack of replication of vaccine virus in the immunized cattle indicated that they are capable of showing a protective response if challenged with a virulent virus.
Naik
S
S
Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, India.
Renukaradhya
G J
GJ
Rajasekhar
M
M
Shaila
M S
MS
D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D002417:Cattle; D002522:Chlorocebus aethiops; D005822:Genetic Vectors; D006389:Hemagglutinins, Viral / Q000235:genetics / Q000276:immunology*; D017924:Nucleopolyhedroviruses; D012302:Rinderpest virus / Q000276:immunology*; D018411:Spodoptera / Q000166:cytology; D014613:Vaccines, Attenuated / Q000276:immunology; D014614:Vaccines, Synthetic / Q000276:immunology*; D014709:Vero Cells; D014765:Viral Vaccines / Q000276:immunology*
D000914:Antibodies, Viral; D006389:Hemagglutinins, Viral; D014613:Vaccines, Attenuated; D014614:Vaccines, Synthetic; D014765:Viral Vaccines