title: Propylthiouracil-induced alveolar haemorrhage associated with antineutrophil cytoplasmic antibody.
abstract: Propylthiouracil (PTU) is known to cause vasculitis as a rare complication. We report the case of a patient who developed alveolar haemorrhage and haematuria whilst treated with PTU. The serum was positive for antineutrophil cytoplasmic antibody (ANCA) with myeloperoxidase (MPO) specificity (MPO-ANCA). All symptoms resolved completely after discontinuation of PTU. Alveolar haemorrhage or pulmonary-renal syndrome associated with antineutrophil cytoplasmic antibody with myeloperoxidase specificity may be a new complication of propylthiouracil therapy.
authors.affiliation: Dept of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, Tsukuba-shi, Ibaraki, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Ohtsuka
authors.forename: Y
authors.initials: Y
authors.lastname: Yamashita
authors.forename: M
authors.initials: M
authors.lastname: Doi
authors.forename: S
authors.initials: S
authors.lastname: Hasegawa
mesh_terms: D000328:Adult; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000032:analysis*; D013956:Antithyroid Agents / Q000009:adverse effects*; D005260:Female; D006111:Graves Disease / Q000188:drug therapy; D006470:Hemorrhage / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000276:immunology; D006801:Humans; D008171:Lung Diseases / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000276:immunology; D009195:Peroxidase / Q000276:immunology; D011441:Propylthiouracil / Q000009:adverse effects*; D011859:Radiography
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic; D013956:Antithyroid Agents; D011441:Propylthiouracil; D009195:Peroxidase