title: Evaluation of decoquinate to treat experimental cryptosporidiosis in kids.
abstract: The purpose of this trial was to evaluate the effects of decoquinate at 2.5 mg/kg/day for 21 days to prevent an experimental cryptosporidiosis in kids. Twenty 1-day-old male kids (French Alpin), fed initially goat colostrum heated 1 h at 56 degrees C and fed twice daily with nonmedicated milk replacer, were assigned into 2 groups. Kids of both groups were orally inoculated with 10(6) Cryptosporidium parvum (D0 = inoculation day). Group A kids were kept as nonmedicated controls and group B kids were orally medicated with 2.5 mg/kg/day of decoquinate (Deccox L. Rhône Poulenc Animal Nutrition) for 21 days from D-3 to D17. The studied criteria were body weight gain, oocyst shedding and specific anti-C. parvum immune response. In group A, the inoculation was not followed by mortality; but only by diarrhea and high oocyst shedding. Decoquinate reduced the severity of cryptosporidiosis in group B kids. The treatment prevented episodes of diarrhea and weight gain decrease for the D0-D7 and D0-D14 disease periods but did not allow a better final weight gain. The oocyst shedding was decreased in number and in duration. This parasitic development has induced a specific anti-C. parvum immune response. This drug is well-tolerated by animals and may be recommended in the prevention of ruminant cryptosporidiosis, a disease which has very limited treatment options.
authors.affiliation: INRA, Station de Pathologie Aviaire et de Parasitologie, Nouzilly, France.
authors.forename: R
authors.initials: R
authors.lastname: Mancassola
authors.forename: A
authors.initials: A
authors.lastname: Richard
authors.forename: M
authors.initials: M
authors.lastname: Naciri
mesh_terms: D000818:Animals; D000913:Antibodies, Protozoan / Q000097:blood; D003049:Coccidiostats / Q000627:therapeutic use*; D003457:Cryptosporidiosis / Q000188:drug therapy / Q000276:immunology / Q000469:parasitology / Q000662:veterinary*; D016785:Cryptosporidium parvum / Q000276:immunology / Q000302:isolation & purification; D003667:Decoquinate / Q000627:therapeutic use*; D015511:Goat Diseases / Q000188:drug therapy* / Q000276:immunology / Q000469:parasitology; D006041:Goats; D008297:Male; D015430:Weight Gain
chemical_list: D000913:Antibodies, Protozoan; D003049:Coccidiostats; D003667:Decoquinate