title: Telomeres, not the end of the story.
abstract: Transcription in organisms as diverse as yeast and mammals is subject to chromosomal position effects that result in heritable and variegated patterns of gene expression. Two recent studies have employed a reversible protein-DNA crosslinking method to identify the structural components of heterochromatin in budding yeast. The results show that a complex containing the proteins Rap1, Sir2p, Sir3p and Sir4p is physically associated with nucleosomes at telomere proximal regions, but that the repressive chromatin structure extended by Sir3p overexpression has a different composition.
authors.affiliation: ISREC, Epalinges, Switzerland.
authors.forename: M
authors.initials: M
authors.lastname: Gotta
authors.forename: M
authors.initials: M
authors.lastname: Cockell
mesh_terms: D000818:Animals; D005656:Fungal Proteins / Q000378:metabolism; D006570:Heterochromatin / Q000378:metabolism; D008954:Models, Biological; D015394:Molecular Structure; D009707:Nucleosomes / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism; D016615:Telomere / Q000737:chemistry / Q000378:metabolism*
chemical_list: D005656:Fungal Proteins; D006570:Heterochromatin; D009707:Nucleosomes