title: [Esophago-gastro-duodenoscopy of pediatric patients].
abstract: In total 199 oesophago-gastro-duodenoscopies (OGD) were performed in 71 female and 71 male paediatric patients (three months-15 years, median 8 years 2 months). The endoscopy was performed in general anaesthesia in children less than five years old, and in an intravenous sedation in older patients. The indications for OGD were: recurrent abdominal pain and concomitant positive antibodies against Helicobacter pylori as a part of a scientific project, upper dyspepsia, upper gastrointestinal bleeding, failure to thrive, coeliac disease, suspicion of chronic inflammatory bowel disease and a percutaneous gastrostomy. Seventy-two OGD were carried out in general anaesthesia, 86 in intravenous sedation with midazolam and pethidine and 41 in intravenous midazolam sedation. Complications related to the sedation or to the endoscopy were not observed. Amnesia was reported in 94/95 children who were sedated intravenously with midazolam and pethidine or midazolam alone. Six endoscopies could not be carried out in intravenous sedation because of agitation. In the primary OGD endoscopy revealed a normal mucosa in 121/142 (85%), oesophagitis in four (3%), nodular mucosa in six (4%), gastritis in four (3%) and a duodenal ulcer in one (0.7%). Histology disclosed active or inactive chronic gastritis at the primary endoscopy in 35/69 (51%) of the children with recurrent abdominal pain and antibodies against H. pylori. In children with failure to thrive an avillous duodenal mucosa was seen in 3/32 (9%). A comparison between histological and stereomicroscopical evaluation of the duodenal biopsies revealed agreement in 41/47 (87%). We conclude that OGD is a safe and tolerable procedure in paediatric patients, in whom possible morphological changes are suspected. The indications for an OGD need further evaluation.
authors.affiliation: H:S Hvidovre Hospital, børneafdelingen, medicinsk gastroenterologisk afdeling.
authors.forename: A V
authors.initials: AV
authors.lastname: Wewer
authors.forename: P U
authors.initials: PU
authors.lastname: Becker
authors.forename: A
authors.initials: A
authors.lastname: Paerregaard
authors.forename: F
authors.initials: F
authors.lastname: Bendtsen
authors.forename: A B
authors.initials: AB
authors.lastname: Gernow
authors.forename: P A
authors.initials: PA
authors.lastname: Krasilnikoff
authors.forename: P
authors.initials: P
authors.lastname: Matzen
mesh_terms: D015746:Abdominal Pain / Q000175:diagnosis; D000293:Adolescent; D000367:Age Factors; D000768:Anesthesia, General; D002648:Child; D002675:Child, Preschool; D004384:Duodenoscopy / Q000009:adverse effects / Q000592:standards / Q000706:statistics & numerical data; D004945:Esophagoscopy / Q000009:adverse effects / Q000379:methods / Q000706:statistics & numerical data; D005260:Female; D005767:Gastrointestinal Diseases / Q000175:diagnosis / Q000382:microbiology; D005773:Gastroscopy / Q000009:adverse effects / Q000592:standards / Q000706:statistics & numerical data; D016480:Helicobacter pylori / Q000276:immunology; D006801:Humans; D007223:Infant; D008297:Male; D012189:Retrospective Studies