title: Proportionate reversible decreases in systolic function and myocardial oxygen consumption after modest reductions in coronary flow: hibernation versus stunning.
abstract: OBJECTIVE
  This study sought to determine whether modest short-term reductions in coronary flow can produce subsequent proportionate reductions in myocardial function and O2 consumption compatible with myocardial hibernation.
  
  
  BACKGROUND
  Acute studies indicate that myocardial energy utilization can be downregulated during moderate flow reduction. Whether this apparently beneficial adjustment persists into the reperfusion period is unsettled because most postischemic contractile dysfunction has been presumed to represent stunned or irreversibly injured myocardium.
  
  
  METHODS
  Responses of regional myocardial function and O2 consumption were assessed in chronically instrumented dogs after approximately 50% reductions in flow for 2 h (n = 8) or repeated 2-min total coronary occlusions (n = 6).
  
  
  RESULTS
  When unrestricted perfusion was restored after sustained partial occlusions, regional function and O2 consumption stabilized at proportionate, systematically decreased levels ([mean +/- SEM] 80 +/- 3.1% and 81 +/- 5.1% of control values, both p < 0.05) and then returned to control values within 24 h. Similar proportionate reductions occurred after as few as five cycles of brief total occlusion (79 +/- 5.1% and 83 +/- 1.6% of control values, both again p < 0.05); these persisted with additional occlusions and then returned to baseline values within 3 h. The absence of irreversible injury was documented histologically in both series. Sham animals (n = 5) showed no changes in regional function or O2 consumption throughout similar experimental periods.
  
  
  CONCLUSIONS
  Moderate decreases in coronary flow or repeated brief coronary occlusions can be followed by proportionate reversible reductions in regional systolic function and O2 consumption compatible with the traditional definition of myocardial hibernation. These findings emphasize the complexity of myocardial responses to flow restriction and call attention to limitations in characterizing reversibly hypocontractile myocardium as simply hibernating or stunned.
authors.affiliation: Feinberg Cardiovascular Research Institute and Department of Medicine, Northwestern University Medical School, Chicago, Illinois 60611-3008, USA.
authors.forename: A J
authors.initials: AJ
authors.lastname: Sherman
authors.forename: K R
authors.initials: KR
authors.lastname: Harris
authors.forename: S
authors.initials: S
authors.lastname: Hedjbeli
authors.forename: Y
authors.initials: Y
authors.lastname: Yaroshenko
authors.forename: D
authors.initials: D
authors.lastname: Schafer
authors.forename: S
authors.initials: S
authors.lastname: Shroff
authors.forename: J
authors.initials: J
authors.lastname: Sung
authors.forename: F J
authors.initials: FJ
authors.lastname: Klocke
mesh_terms: D000818:Animals; D003251:Constriction, Pathologic; D003331:Coronary Vessels / Q000503:physiopathology*; D004285:Dogs; D005260:Female; D006439:Hemodynamics; D008297:Male; D017682:Myocardial Stunning / Q000503:physiopathology*; D009206:Myocardium / Q000378:metabolism*; D010101:Oxygen Consumption; D012039:Regional Blood Flow; D013599:Systole / Q000502:physiology*