Effect of the appetite stimulant cyproheptadine on deoxynivalenol-induced reductions in feed consumption and weight gain in the mouse.
Deoxynivalenol (DON, vomitoxin), a Fusarium mycotoxin, is suspected of inducing its anorectic/feed refusal activity through a serotoninergic (5HT) mechanism, possible via 5HT2-receptors. In this study the efficiency of cyproheptadine (CYP), a serotonin antagonist and known appetite stimulant, to attenuate the adverse effect of DON was investigated in mice. CYP was administered in the feed for two days before animals began receiving the DON, which was also added to the feed. Both agents were administered concurrently thereafter for a 12-day period. Dosing levels included various combinations of the two compounds, ranging from 0-16 ppm DON and 0-20 ppm CYP.
Prelusky
D B
DB
Centre for Food and Animal Research Agriculture and Agri-Food Canada Ottawa, Ontario, Canada.
Rotter
B A
BA
Thompson
B K
BK
Trenholm
H L
HL
D000818:Animals; D019167:Appetite Stimulants / Q000494:pharmacology*; D003533:Cyproheptadine / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D005247:Feeding Behavior / Q000187:drug effects*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009183:Mycotoxins / Q000633:toxicity*; D012702:Serotonin Antagonists / Q000494:pharmacology*; D014255:Trichothecenes / Q000037:antagonists & inhibitors / Q000633:toxicity*; D015430:Weight Gain / Q000187:drug effects
D019167:Appetite Stimulants; D009183:Mycotoxins; D012702:Serotonin Antagonists; D014255:Trichothecenes; D003533:Cyproheptadine; C007262:deoxynivalenol