Cellular adhesion to laminin involves a chondroitin sulfate proteoglycan.
Cell-extracellular matrix interactions are intimately involved in the regulation of many cellular processes such as embryonic development or tumor cell growth and metastasis. In our previous work we were able to detect a 90/100-kDa laminin binding chondroitin sulfate proteoglycan. A search for this molecule in different cell lines showed that it is only found in cells that adhere to laminin.
Elias
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MC
Instituto Ludwig de Pesquisas sobre o Cãncer, São Paulo, Brasil.
Veiga
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Gremski
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Brentani
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D002448:Cell Adhesion / Q000502:physiology*; D015815:Cell Adhesion Molecules / Q000378:metabolism*; D011508:Chondroitin Sulfate Proteoglycans / Q000378:metabolism*; D002809:Chondroitin Sulfates / Q000378:metabolism*; D005109:Extracellular Matrix / Q000378:metabolism; D007797:Laminin / Q000378:metabolism*; D009362:Neoplasm Metastasis
D015815:Cell Adhesion Molecules; D011508:Chondroitin Sulfate Proteoglycans; D007797:Laminin; D002809:Chondroitin Sulfates