[Nimodipine, nifedipine and the cerebrovascular effects of serotonin].
Experiments on rats with the use of ultrasonic techniques demonstrated that serotonin causes an initial significant decrease in the blood flow in the channel of the middle cerebral artery followed by a mild increase in the blood supply to the brain. It was shown in in vivo experiments that nimodipine and nifedipine do not prevent the development of serotonin-induced constriction of the vessels of the middle cerebral artery channel. At the same time, the cerebrovascular effects of nimodipine and nifedipine are significantly weakened under the action of serotonin.
Semkina
G A
GA
Matsievskiĭ
D D
DD
Mirzoian
R S
RS
D000818:Animals; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D017536:Carotid Artery, Common / Q000000981:diagnostic imaging / Q000187:drug effects; D002536:Cerebral Arteries / Q000000981:diagnostic imaging / Q000187:drug effects; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D004347:Drug Interactions; D008297:Male; D009543:Nifedipine / Q000494:pharmacology*; D009553:Nimodipine / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012701:Serotonin / Q000494:pharmacology*; D013997:Time Factors; D014463:Ultrasonography; D014661:Vasoconstriction / Q000187:drug effects
D002121:Calcium Channel Blockers; D012701:Serotonin; D009553:Nimodipine; D009543:Nifedipine