title: ATP/ADP antiporter- and aspartate/glutamate antiporter-mediated fatty acid-induced uncoupling of liver mitochondria in incubation media differing in ion composition.
abstract: Substitution of potassium cloride for sucrose in the incubation medium of liver mitochondria or addition of magnesium cloride to the sucrose medium produces a small (if any) effect on the palmitate-induced uncoupling and its sensitivity to carboxyatractylate and aspartate, but it exerts a pronounced increase in the recoupling effect of glutamate on this uncoupling. 20-40 microM cetyltrimethyl ammonium bromide increases the recoupling effect of glutamate and aspartate but decreases that of carboxyatractylate. The data are in line with suggestion that both ATP/ADP antiporter and aspartate/glutamate antiporters are involved in the fatty acid-induced uncoupling.
authors.affiliation: Mari State University, Yoshkar-Ola.
authors.forename: V N
authors.initials: VN
authors.lastname: Samartsev
authors.forename: E N
authors.initials: EN
authors.lastname: Mokhova
mesh_terms: D026922:Amino Acid Transport Systems, Acidic; D000818:Animals; D017920:Antiporters; D001224:Aspartic Acid / Q000494:pharmacology; D001278:Atractyloside / Q000031:analogs & derivatives / Q000494:pharmacology; D002352:Carrier Proteins / Q000378:metabolism*; D000077286:Cetrimonium; D002593:Cetrimonium Compounds / Q000494:pharmacology; D018698:Glutamic Acid / Q000494:pharmacology; D015636:Magnesium Chloride / Q000494:pharmacology; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism*; D000226:Mitochondrial ADP, ATP Translocases / Q000378:metabolism*; D019308:Palmitic Acid / Q000494:pharmacology*; D011189:Potassium Chloride / Q000494:pharmacology; D051381:Rats; D014475:Uncoupling Agents / Q000494:pharmacology*
chemical_list: D026922:Amino Acid Transport Systems, Acidic; D017920:Antiporters; D002352:Carrier Proteins; D002593:Cetrimonium Compounds; D014475:Uncoupling Agents; C051046:aspartate-glutamate carrier; D015636:Magnesium Chloride; D001278:Atractyloside; D019308:Palmitic Acid; D001224:Aspartic Acid; D018698:Glutamic Acid; D011189:Potassium Chloride; D000226:Mitochondrial ADP, ATP Translocases; C003853:carboxyatractyloside; D000077286:Cetrimonium