title: [Effect of nitrous oxide at sub-MAC concentrations on sevoflurane MAC in adults].
abstract: The interaction of sevoflurane and nitrous oxide (N2O) on the MAC was studied in the four groups of patients between 30-60 years of age scheduled for laparotomies. Patients received one of four different concentrations of N2O [0% (n = 14), 25% (n = 16), 50% (n = 15), or 70% (n = 18)]. Anesthesia was induced with sevoflurane and N2O using a semiclosed circuit with a carbon dioxide absorber. After endotracheal intubation, sevoflurane and N2O end-tidal concentrations were adjusted to predetermined concentrations until the skin incision was made. The MAC values for sevoflurane in O2 and the presence of 25%, 50%, and 70% N2O were 1.68%, 1.33%, 0.82% and 0.55%, respectively. A regression analysis through all four data points yielded a linear relationship (r = -0.997). The requirement of sevoflurane decreased by approximately 1% for each 1% of N2O administered at three N2O concentrations. The extrapolated MAC value for N2O was 102%. The MAC values of sevoflurane in O2 and N2O were similar to the previously reported values. We conclude that in adults, N2O concentrations in the dose range 0-70% reduce sevoflurane MAC in a linearly additive manner.
authors.affiliation: Department of Anesthesia, Tokushima Municipal Hospital.
authors.forename: T
authors.initials: T
authors.lastname: Nakahara
authors.forename: T
authors.initials: T
authors.lastname: Akazawa
authors.forename: J
authors.initials: J
authors.lastname: Nozaki
authors.forename: Y
authors.initials: Y
authors.lastname: Sasaki
mesh_terms: D000328:Adult; D018685:Anesthetics, Inhalation / Q000493:pharmacokinetics*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D004987:Ethers / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D008297:Male; D008738:Methyl Ethers; D008875:Middle Aged; D009609:Nitrous Oxide / Q000008:administration & dosage / Q000494:pharmacology*; D011650:Pulmonary Alveoli / Q000378:metabolism*; D000077149:Sevoflurane
chemical_list: D018685:Anesthetics, Inhalation; D004987:Ethers; D008738:Methyl Ethers; D000077149:Sevoflurane; D009609:Nitrous Oxide