Protein sorting and secretion during CTL killing.
Now that the key proteins involved in target cell destruction during the lethal hit from CTL have been identified, an understanding of the mechanisms which regulate their delivery becomes important for understanding their relative contributions during CTL killing. This review summarizes what is known about the packaging and delivery of the different effector proteins involved in target cell destruction. The mechanisms which regulate their delivery during killing contribute to some of the unusual features of CTL killing, and give some clues about the different contributions in target cell destruction.
Griffiths
G M
GM
MRC Lab for Molecular Cell Biology, University College London, UK.
D000818:Animals; D002451:Cell Compartmentation; D015550:Cell Degranulation; D002460:Cell Line; D003602:Cytotoxicity, Immunologic; D005089:Exocytosis; D053804:Granzymes; D006801:Humans; D008213:Lymphocyte Activation; D008247:Lysosomes / Q000201:enzymology; D008562:Membrane Glycoproteins / Q000378:metabolism; D054353:Perforin; D052899:Pore Forming Cytotoxic Proteins; D051381:Rats; D017527:Receptor, IGF Type 2 / Q000502:physiology; D012697:Serine Endopeptidases / Q000378:metabolism; D013602:T-Lymphocytes, Cytotoxic
D008562:Membrane Glycoproteins; D052899:Pore Forming Cytotoxic Proteins; D017527:Receptor, IGF Type 2; D054353:Perforin; D053804:Granzymes; D012697:Serine Endopeptidases; C509212:GZMA protein, human