Antifungal diterpenoid alkaloids from Delphinium denudatum.
The roots of Delphinium denudatum have yielded a new diterpenoid alkaloid, 8-acetylheterophyllisine (1), in addition to the known alkaloids vilmorrianone (2), panicutine (3), denudatine (4), isotalatizidine (5), and condelphine (6), as well as 3-hydroxy-2-methyl-4H-pyran-4-one (7). Compounds 1, 3, and 7 have not been isolated from this plant previously. The structures of compounds 1, 3, and 7 were determined through spectral and X-ray diffraction analyses. Compounds 1-3 have shown antifungal activity against a number of human pathogenic fungi.
Atta-ur-Rahman
H.E.J. Research Institute of Chemistry, University of Karachi, Pakistan.
Nasreen
A
A
Akhtar
F
F
Shekhani
M S
MS
Clardy
J
J
Parvez
M
M
Choudhary
M I
MI
D000470:Alkaloids / Q000302:isolation & purification* / Q000494:pharmacology; D000935:Antifungal Agents / Q000302:isolation & purification* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D004224:Diterpenes / Q000302:isolation & purification* / Q000494:pharmacology; D005658:Fungi / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D013056:Spectrophotometry, Ultraviolet
D000470:Alkaloids; D000935:Antifungal Agents; D004224:Diterpenes