[Effects of induction propofol mono-narcosis on the central and cerebral hemodynamics].
Changes in the central hemodynamics were followed up by echocardiography and the linear velocity of the bloodflow by transcranial dopplerography in 15 patients with ASA classes I-II during induction bolus anesthesia with propofol in a dose 2.7 mg/kg without opioids. The diastolic and mean arterial pressure decreased by 12.3 and 15.4 %, respectively, the rate of cardiac contractions by 7.8%, cardiac index by 13.4%, and the resistive index on the radial and middle cerebral arteries by 13.4 and 10.2%, respectively, after administration of the above dose of propofol. The reaction to intubation of the trachea was the minimal, consisting in an increase of the mean and systolic arterial pressure by 22.2 and 22.7%, respectively, and of diastolic by 16.1%. The rest parameters were as initially. The linear velocity of the bloodflow in the middle cerebral artery did not reliably change. Hence, the central hemodynamic parameters are stable on condition that the deficit in the central bloodflow during induction anesthesia with propofol in a dose of 2.7 mg/kg is compensated for, adequate protection from intubation stress is provided, and autoregulation of the cerebral bloodflow is preserved.
Grinberg
B I
BI
Levit
A L
AL
Kotov
N B
NB
Piskunova
O M
OM
D000328:Adult; D018686:Anesthetics, Intravenous / Q000494:pharmacology*; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D004452:Echocardiography; D006439:Hemodynamics / Q000187:drug effects*; D006706:Homeostasis; D006801:Humans; D007442:Intubation, Intratracheal; D008875:Middle Aged; D015742:Propofol / Q000494:pharmacology*; D017585:Ultrasonography, Doppler, Transcranial
D018686:Anesthetics, Intravenous; D015742:Propofol