title: The relationship between weight and response to cholesterol-lowering diets in women.
abstract: OBJECTIVE
  To determine whether factors related to body weight might influence the cholesterol lowering response to diet.
  
  
  METHODS
  Run-In diet followed by crossover to low fat diets; average response is reported.
  
  
  METHODS
  Sixty-three subjects (30 men and 33 women) with moderately elevated plasma cholesterol levels.
  
  
  METHODS
  Lipid and anthropometric measurements. Data were analyzed as a repeated measures analysis of variance with lipid lowering response in all combined cholesterol lowering diets compared to baseline.
  
  
  RESULTS
  LDL cholesterol lowering was significantly affected by BMI in women (P = 0.01) but not in men (P = 0.54). There was also a weak effect of waist-hip (W/H) ratio on response (P = 0.127) in women, with the lower responders having a higher W/H ratio but there was no effect of W/H ratio in men (P = 0.86).
  
  
  CONCLUSIONS
  These results suggest that overweight women with elevated plasma cholesterol may be less responsive to reducing their cholesterol levels with diet.
authors.affiliation: Medlantic Research Institute, Washington, DC 20010-2933, USA.
authors.forename: J S
authors.initials: JS
authors.lastname: Hannah
authors.forename: K A
authors.initials: KA
authors.lastname: Jablonski
authors.forename: B V
authors.initials: BV
authors.lastname: Howard
mesh_terms: D000328:Adult; D001824:Body Constitution; D015992:Body Mass Index; D001835:Body Weight; D002784:Cholesterol / Q000097:blood*; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D004032:Diet; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000178:diet therapy*; D008297:Male; D008875:Middle Aged; D014280:Triglycerides / Q000097:blood
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D014280:Triglycerides; D002784:Cholesterol