[Application of alpha-hANP for the management following open-heart surgery: report of two cases].
Alpha-human atrial natriuretic peptide (alpha-hANP) has a vasodilating and diuretic action. Intravenous continuous administration of alpha hANP (0.05 microgram/kg/min) was attempted for two patients with low urine output despite good hemodynamics following open-heart surgery. Following the administration of alpha-hANP, urine volume increased markedly, and central venous and pulmonary capillary wedge pressures immediately decreased. Intravenous continuous administration of alpha-hANP is useful for the management of patients associated with the volume overload following open-heart surgery.
Mohara
J
J
Second Department of Surgery, Gunma University School of Medicine, Japan.
Ishikawa
S
S
Ohtaki
A
A
Takahashi
T
T
Ohki
S
S
Yamagishi
T
T
Morishita
Y
Y
Koyano
T
T
Isa
Y
Y
Kunimoto
F
F
D000368:Aged; D001022:Aortic Valve Insufficiency / Q000503:physiopathology / Q000601:surgery; D009320:Atrial Natriuretic Factor / Q000008:administration & dosage*; D006348:Cardiac Surgical Procedures; D004232:Diuretics / Q000008:administration & dosage*; D006350:Heart Valve Prosthesis; D006439:Hemodynamics; D006801:Humans; D008297:Male; D008875:Middle Aged; D008944:Mitral Valve Insufficiency / Q000503:physiopathology / Q000601:surgery; D010446:Peptide Fragments / Q000008:administration & dosage*; D011182:Postoperative Care
D004232:Diuretics; D010446:Peptide Fragments; D009320:Atrial Natriuretic Factor