title: Effects of manual high-impulse CPR on myocardial perfusion during cardiac arrest in pigs.
abstract: The aim of the study was to compare the effect of a 30 and 50% duty cycle on coronary perfusion pressure (CPP) and end tidal carbon dioxide (ETCO2) and to determine whether a duty cycle of 30% can be achieved manually. After 3 min of ventricular fibrillation cardiac arrest, pigs were resuscitated in two groups with changing duty cycles every 3 min: group A starting with 50 and then 30%; and group B starting with 30 and then 50%. After administration of epinephrine, duty cycles in group A were 50 and then 30%, in group B initially 30% and then 50% Before administration of epinephrine, no significant differences in CPP between the 30 and 50% duty cycles were found; after epinephrine CPP increased with both duty cycles. ETCO2 did not vary before epinephrine; after epinephrine, there were statistically significant differences but there is doubt regarding the clinical relevance of these differences. Survival was 4/6 in group A and 3/5 in group B (NS). It is possible to perform a manual duty cycle of 30%. However, our data do not support the use of a 30% duty cycle during cardiopulmonary resuscitation (CPR).
authors.affiliation: Department of Emergency Medicine, University of Vienna, Medical School, Austria.
authors.forename: W
authors.initials: W
authors.lastname: Behringer
authors.forename: F
authors.initials: F
authors.lastname: Sterz
authors.forename: H
authors.initials: H
authors.lastname: Domanovits
authors.forename: B
authors.initials: B
authors.lastname: Hohenberger
authors.forename: W
authors.initials: W
authors.lastname: Schörkhuber
authors.forename: M
authors.initials: M
authors.lastname: Frass
authors.forename: U
authors.initials: U
authors.lastname: Losert
authors.forename: A N
authors.initials: AN
authors.lastname: Laggner
mesh_terms: D000818:Animals; D001794:Blood Pressure; D002245:Carbon Dioxide; D016887:Cardiopulmonary Resuscitation / Q000379:methods*; D003326:Coronary Circulation / Q000187:drug effects; D004837:Epinephrine / Q000494:pharmacology; D006323:Heart Arrest / Q000503:physiopathology* / Q000628:therapy*; D011312:Pressure; D013552:Swine; D013599:Systole; D013909:Thorax; D013990:Tidal Volume; D014662:Vasoconstrictor Agents / Q000494:pharmacology
chemical_list: D014662:Vasoconstrictor Agents; D002245:Carbon Dioxide; D004837:Epinephrine