title: The eight-item treatment-outcome post-traumatic stress disorder scale: a brief measure to assess treatment outcome in post-traumatic stress disorder.
abstract: This preliminary report describes a new brief interview based assessment of post-traumatic stress disorder using an 8-item treatment-outcome post-traumatic stress disorder scale (TOP-8). The TOP-8 was developed from a larger post-traumatic stress disorder evaluation scale based on items which occurred frequently in the population and which responded substantially to treatment across time. The 8 resultant items were drawn from all three symptom clusters for post-traumatic stress disorder, and showed an improved ability to detect drug versus placebo differences in comparison with the original scale. The eight-item treatment-outcome post-traumatic stress disorder scale also correlated significantly with a self-rated measure of post-traumatic stress disorder and distinguished at a highly significant level between responders and non-responders on an independently judged Clinical Global Impressions measure. The results of this study are discussed and future directions suggested.
authors.affiliation: Duke University Medical Center, Durham, North Carolina 27710, USA.
authors.forename: J R
authors.initials: JR
authors.lastname: Davidson
authors.forename: J T
authors.initials: JT
authors.lastname: Colket
mesh_terms: D000328:Adult; D018687:Antidepressive Agents, Second-Generation / Q000627:therapeutic use*; D005260:Female; D005473:Fluoxetine / Q000627:therapeutic use*; D006801:Humans; D007406:Interview, Psychological; D008297:Male; D015588:Observer Variation; D011569:Psychiatric Status Rating Scales / Q000592:standards*; D015203:Reproducibility of Results; D013313:Stress Disorders, Post-Traumatic / Q000188:drug therapy* / Q000523:psychology*; D016896:Treatment Outcome
chemical_list: D018687:Antidepressive Agents, Second-Generation; D005473:Fluoxetine