HIV dementia and apolipoprotein E.
The effect of apolipoprotein E genotypes on the occurrence of HIV dementia and HIV encephalitis was studied in a sample of 132 AIDS patients in whom clinical data on dementia was available and full autopsy had been performed. There was no statistically significant correlation between risk of HIV dementia or HIV encephalitis in relation to apolipoprotein E genotypes, even after correction for length of survival with AIDS and antiretroviral treatment.
Dunlop
O
O
Department of Infectious Diseases, Ullevål University Hospital, Oslo, Norway.
Goplen
A K
AK
Liestøl
K
K
Myrvang
B
B
Rootwelt
H
H
Christophersen
B
B
Kvittingen
E A
EA
Maehlen
J
J
D015526:AIDS Dementia Complex / Q000188:drug therapy / Q000235:genetics*; D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use; D001057:Apolipoproteins E / Q000235:genetics*; D001483:Base Sequence; D004587:Electrophoresis, Agar Gel; D018792:Encephalitis, Viral / Q000188:drug therapy / Q000209:etiology / Q000235:genetics; D005260:Female; D005784:Gene Amplification; D005838:Genotype; D006678:HIV / Q000472:pathogenicity; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D015215:Zidovudine / Q000627:therapeutic use
D019380:Anti-HIV Agents; D001057:Apolipoproteins E; D015215:Zidovudine