title: Lignocaine aerosol spray in outpatient hysteroscopy: a randomized double-blind placebo-controlled trial.
abstract: OBJECTIVE
  To assess the efficacy of lignocaine spray during outpatient hysteroscopy in reducing the need for additional anesthesia and reducing the discomfort of the procedure.
  
  
  METHODS
  A randomized double-blind, placebo-controlled trial.
  
  
  METHODS
  An undergraduate university teaching hospital in London.
  
  
  METHODS
  One hundred twenty patients undergoing outpatient hysteroscopy.
  
  
  METHODS
  Application of lignocaine spray to the cervix, cervical canal, and uterine cavity during outpatient hysteroscopy.
  
  
  METHODS
  The need to use additional anesthesia and the pain experienced at various steps of the procedure.
  
  
  RESULTS
  Women treated with active spray experienced significantly less pain when the cervix was grasped with a tenaculum at the start of hysteroscopy. There were no other significant differences in the outcome of hysteroscopy between the placebo and lignocaine groups, although there was a significant reduction in the use of additional anesthesia in both groups compared with historical controls.
  
  
  CONCLUSIONS
  Lignocaine spray has beneficial effects on cervical but not uterine sensation. Pretreatment with either lignocaine or placebo seems to reduce the need for additional intracervical anesthesia during hysteroscopy.
authors.affiliation: Minimally Invasive Therapy Unit, Royal Free Hospital, London, United Kingdom.
authors.forename: A
authors.initials: A
authors.lastname: Davies
authors.forename: R E
authors.initials: RE
authors.lastname: Richardson
authors.forename: H
authors.initials: H
authors.lastname: O'Connor
authors.forename: T F
authors.initials: TF
authors.lastname: Baskett
authors.forename: F
authors.initials: F
authors.lastname: Nagele
authors.forename: A L
authors.initials: AL
authors.lastname: Magos
mesh_terms: D000328:Adult; D000336:Aerosols; D000779:Anesthetics, Local / Q000008:administration & dosage*; D002584:Cervix Uteri; D005260:Female; D006801:Humans; D015907:Hysteroscopy; D008012:Lidocaine / Q000008:administration & dosage*; D008875:Middle Aged; D010147:Pain Measurement; D017699:Pelvic Pain / Q000517:prevention & control; D010919:Placebos; D014599:Uterus
chemical_list: D000336:Aerosols; D000779:Anesthetics, Local; D010919:Placebos; D008012:Lidocaine