Responses of the dural circulation to electrical stimulation of the trigeminal ganglion in the cat.
1. In cats anaesthetized with alpha-chloralose, electrical stimulation (ES) of the trigeminal ganglion produced a fall in blood pressure, a predominantly ipsilateral dilatation in the common carotid vascular bed and bilateral dilatation of the middle meningeal vascular bed. Section of the trigeminal root abolished these responses. 2. Dilatation in the middle meningeal artery was not affected by section of the cervical sympathetic trunk nor by the section of the seventh cranial nerve trunk. The dilator response was abolished by section of the spinal cord at the C3 level and by intravenous administration of bretylium (10 mg/kg) or phentolamine (5 mg/kg). The response was significantly reduced by the prior administration of papaverine (10 mg/kg). 3. Functional adrenalectomy by means of a snare placed around the nerves and blood vessels supplying the adrenal glands significantly reduced the response. Electrical stimulation of the trigeminal ganglion was accompanied by a fall in circulating levels of noradrenaline and serotonin. 4. We conclude that ES of the trigeminal ganglion produces dilatation in the middle meningeal artery partly by autoregulation during the trigeminal depressor response and partly by a reduction in the circulating levels of noradrenaline. It differs from the dilatation seen in the general carotid circulation and the cortical microcirculation, which is mediated by parasympathetic nerves. There is no evidence that antidromic release of neuropeptides from sensory nerve endings in the dura plays a part in the dilatation.
Lambert
G A
GA
Institute of Neurological Sciences, Prince Henry Hospital, Little Bay, New South Wales, Australia. G.Lambert@unsw.edu.au
Michalicek
J
J
Regaglia
F
F
D000315:Adrenalectomy; D000818:Animals; D001679:Biogenic Amines / Q000097:blood; D001949:Bretylium Compounds / Q000494:pharmacology; D002415:Cats; D002818:Cordotomy; D004388:Dura Mater / Q000098:blood supply*; D004558:Electric Stimulation; D005154:Facial Nerve / Q000502:physiology; D018738:Hexamethonium / Q000494:pharmacology; D010208:Papaverine / Q000494:pharmacology; D010646:Phentolamine / Q000494:pharmacology; D013116:Spinal Cord / Q000502:physiology; D013562:Sympathectomy; D009435:Synaptic Transmission / Q000187:drug effects; D012668:Trigeminal Ganglion / Q000502:physiology*; D014276:Trigeminal Nerve / Q000502:physiology
D001679:Biogenic Amines; D001949:Bretylium Compounds; D018738:Hexamethonium; D010208:Papaverine; C045166:bretylium; D010646:Phentolamine