Development of a dural substitute from synthetic bioabsorbable polymers.
A new bioabsorbable composite sheet was developed to provide a substitute for the dura mater and was evaluated histologically and biomechanically using rats and rabbits. This composite, composed of two L-lactic acid-epsilon-caprolactone (50% L-lactic acid, 50% epsilon-caprolactone) copolymer films and a poly(glycolic acid) nonwoven fabric, displayed good mechanical properties and was completely absorbed 24 weeks after implantation in the back of rats. Histological evaluation of the composite sheet was undertaken by implanting it in 31 rabbits with dural defects and examining the sites of implantation 2 weeks to 26 months later. No infection, cerebrospinal fluid leakage, evidence of convulsive disorders, significant adhesion to underlying cortex, or calcification was noticed in any cases. In addition, the regenerated duralike tissue had a high pressure-resistant strength 2 weeks after implantation. The authors conclude that this new bioabsorbable composite sheet can be successfully used as a dural substitute.
Yamada
K
K
Department of Neurosurgery, Medical School, and Research Center for Biomedical Engineering, Kyoto University, Sakyo-ku, Japan.
Miyamoto
S
S
Nagata
I
I
Kikuchi
H
H
Ikada
Y
Y
Iwata
H
H
Yamamoto
K
K
D000042:Absorption; D000293:Adolescent; D000328:Adult; D000818:Animals; D001672:Biocompatible Materials / Q000493:pharmacokinetics*; D001673:Biodegradation, Environmental; D001921:Brain / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D004388:Dura Mater / Q000473:pathology / Q000601:surgery*; D004867:Equipment Design; D006801:Humans; D019344:Lactic Acid; D008875:Middle Aged; D011091:Polyesters; D011100:Polyglycolic Acid; D011108:Polymers / Q000493:pharmacokinetics*; D011184:Postoperative Period; D019736:Prostheses and Implants; D011817:Rabbits; D051381:Rats
D001672:Biocompatible Materials; D011091:Polyesters; D011108:Polymers; C016240:polycaprolactone; D011100:Polyglycolic Acid; D019344:Lactic Acid