title: Clinical features of childhood-onset schizophrenia with obsessive-compulsive symptoms during the prodromal phase.
abstract: Thirty-nine patients with schizophrenia, diagnosed according to DSM-III-R, who were under 15 years of age, were studied in two groups; 16 subjects with obsessive-compulsive symptoms during the prodromal phase, and 23 with no obsessive-compulsive disorders. The group with obsessive-compulsive symptoms during the prodromal phase was characterized by a higher ratio of males, higher incidences of perinatal and brain computed tomography (CT) abnormalities, fewer hereditary factors, longer duration of the prodromal phase, and a higher incidence of insidious onset and negative symptoms compared with the group without such prodromal symptoms. Schizophrenic patients with obsessive-compulsive symptoms during the prodromal phase were clinically distinct from those without, which suggests the possibility of subtype categorization.
authors.affiliation: Department of Psychiatry, Nara Medical University, Japan.
authors.forename: J
authors.initials: J
authors.lastname: Iida
authors.forename: H
authors.initials: H
authors.lastname: Iwasaka
authors.forename: F
authors.initials: F
authors.lastname: Hirao
authors.forename: K
authors.initials: K
authors.lastname: Hashino
authors.forename: K
authors.initials: K
authors.lastname: Matsumura
authors.forename: K
authors.initials: K
authors.lastname: Tahara
authors.forename: F
authors.initials: F
authors.lastname: Aoyama
authors.forename: S
authors.initials: S
authors.lastname: Sakiyama
authors.forename: H
authors.initials: H
authors.lastname: Tsujimoto
authors.forename: Y
authors.initials: Y
authors.lastname: Kawabata
authors.forename: G
authors.initials: G
authors.lastname: Ikawa
mesh_terms: D000293:Adolescent; D017668:Age of Onset; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D009771:Obsessive-Compulsive Disorder / Q000235:genetics / Q000523:psychology*; D010551:Personality; D011569:Psychiatric Status Rating Scales; D012561:Schizophrenia, Childhood / Q000235:genetics / Q000523:psychology*; D012565:Schizophrenic Psychology; D012744:Sex Ratio; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome