[The role of the interaction of serotonin- and noradrenergic systems in regulating behavior].
A review of the data concerning the role of 5-hydroxytriptamine (5HT)-ergic and noradrenergic (NA) system in the regulation of behavior. Reciprocal effects of cerebral 5HT-ergic and NA-ergic systems on brain morphogenesis and on behavior suggest that normal brain ontogenesis is mediated by the steady state of 5HT and NA. The disbalance between 5HT-ergic and NA-ergic systems in brain structures results in abnormal brain development and behavioral pathologies. The concept of reciprocal effects of 5HT-ergic and NA-ergic brain systems may serve as a basis for new principles of pharmacological correction of pathologies resulting from inborn or acquired disbalance of monoaminergic systems.
Semenova
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D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology*; D001921:Brain / Q000187:drug effects / Q000502:physiology; D009498:Neurotoxins / Q000494:pharmacology; D011941:Receptors, Adrenergic / Q000187:drug effects / Q000502:physiology*; D011985:Receptors, Serotonin / Q000187:drug effects / Q000502:physiology*
D009498:Neurotoxins; D011941:Receptors, Adrenergic; D011985:Receptors, Serotonin