title: Neonatal symptomatic thromboembolism in Germany: two year survey.
abstract: OBJECTIVE
  To determine the incidence of neonatal thromboembolism in Germany.
  
  
  METHODS
  Diagnostic imaging techniques, therapeutic modalities, and short term outcome were evaluated in a prospective nationwide two year case registry study.
  
  
  RESULTS
  The reported incidence of symptomatic neonatal thromboembolism, diagnosed in most cases with Doppler ultrasonography, was 5.1 per 100000 births, with a total of 79 cases registered: renal venous thrombosis (n = 35); venous thrombosis (n = 25); and arterial vascular occlusion (n = 19). Fifty seven of 79 thromboses were associated with additional risk factors (central line n = 25, asphyxia n = 13, septicaemia n = 11, dehydration n = 6, maternal diabetes n = 2, cardiac disease n = 1). Inherited thrombophilia was also diagnosed in seven out of 35 cases investigated. Twenty three children received supportive treatment: 42 received heparin and in 13 neonates thrombolytic agents were administered. Most neonates (91%) survived; seven died.
  
  
  CONCLUSIONS
  Controlled multicentre studies are needed to obtain more information on treatment efficacy.
authors.affiliation: Department of Paediatrics, University Hospital of Münster, Germany.
authors.forename: U
authors.initials: U
authors.lastname: Nowak-Göttl
authors.forename: R
authors.initials: R
authors.lastname: von Kries
authors.forename: U
authors.initials: U
authors.lastname: Göbel
mesh_terms: D000925:Anticoagulants / Q000627:therapeutic use; D005858:Germany / Q000453:epidemiology; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D011446:Prospective Studies; D013923:Thromboembolism / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000453:epidemiology*; D015912:Thrombolytic Therapy; D016896:Treatment Outcome; D018608:Ultrasonography, Doppler
chemical_list: D000925:Anticoagulants; D006493:Heparin