title: Effects of powder on infection risks and associated mechanisms.
abstract: This paper examines the release of Tumour necrosis factor alpha, (TNFa) interleukin 1, eicosanoids, and hydrogen peroxide from macrophages exposed to glove starch particles. Studies are described which show that T-cell responses are potently activated by glove powder products leading to the release and formation of high amounts of pro-inflammatory mediators, ultimately resulting in adverse clinical consequences such as starch peritonitis or adhesions.
authors.affiliation: Laboratory Medicine and Immunopathology, Humboldt University of Berlin, Germany.
authors.forename: H
authors.initials: H
authors.lastname: Renz
authors.forename: D
authors.initials: D
authors.lastname: Gemsa
mesh_terms: D000818:Animals; D001424:Bacterial Infections / Q000209:etiology*; D002465:Cell Movement; D002478:Cells, Cultured; D015777:Eicosanoids / Q000378:metabolism; D005932:Gloves, Surgical; D015745:Granuloma, Foreign-Body / Q000209:etiology; D006801:Humans; D006861:Hydrogen Peroxide / Q000378:metabolism; D007111:Immunity, Cellular / Q000187:drug effects*; D018836:Inflammation Mediators / Q000276:immunology / Q000378:metabolism; D007375:Interleukin-1 / Q000276:immunology; D008213:Lymphocyte Activation / Q000187:drug effects / Q000276:immunology; D008262:Macrophage Activation / Q000187:drug effects / Q000276:immunology; D017737:Macrophages, Peritoneal / Q000187:drug effects / Q000276:immunology; D010529:Peritoneal Cavity; D010532:Peritoneal Diseases / Q000209:etiology / Q000276:immunology; D010538:Peritonitis / Q000209:etiology / Q000276:immunology; D011208:Powders / Q000009:adverse effects; D051381:Rats; D012307:Risk Factors; D013213:Starch / Q000009:adverse effects*; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology; D000267:Tissue Adhesions / Q000209:etiology / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology
chemical_list: D015777:Eicosanoids; D018836:Inflammation Mediators; D007375:Interleukin-1; D011208:Powders; D014409:Tumor Necrosis Factor-alpha; D013213:Starch; D006861:Hydrogen Peroxide