Activation of chemosensitive neurons in the ventrolateral medulla by capsaicin in cats.
We examined effects of centrally administered capsaicin on sympathetic nerve activity (SNA), blood pressure (BP) and heart rate (HR) in chloralose anesthetized cats (n = 18). Upon perfusion of the lower brain stem via the left vertebral artery, capsaicin (0.1-1.0 microM) caused dose-dependent increases in preganglionic SNA (recorded from the white ramus T3) that were associated with rises in BP and HR. These responses resembled closely those obtained during perfusions with CO2-enriched (40-80%) saline. Coadministration of capsaicin and CO2 resulted in additively increased responses. The effects of capsaicin, but not those of CO2, were significantly counteracted by the capsaicin antagonist capsazepine and ruthenium red. These results suggest that a specific central chemosensitivity activated by vanilloid receptor agonists may modulate hypercapnic and/or acidic sympathoexcitatory stimuli in vivo.
Seller
H
H
I. Physiologisches Institut, Universität Heidelberg, Germany.
Czachurski
J
J
Zanzinger
J
J
D000704:Analysis of Variance; D000818:Animals; D001339:Autonomic Fibers, Preganglionic / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects*; D002211:Capsaicin / Q000031:analogs & derivatives / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D002415:Cats; D004353:Drug Evaluation, Preclinical; D006339:Heart Rate / Q000187:drug effects*; D008526:Medulla Oblongata / Q000166:cytology / Q000187:drug effects*; D009474:Neurons / Q000187:drug effects*; D012430:Ruthenium Red / Q000494:pharmacology; D013564:Sympathetic Nervous System / Q000187:drug effects*
D012430:Ruthenium Red; C071423:capsazepine; D002211:Capsaicin