[Levels of PCDDs, PCDFs and coplanar PCBs in sebum and blood of Yusho patients].
Polychlorinated dibenzo-p-dioxins (PCDDs) and it's related compounds such as polychlorinated dibenzofurans (PCDFs) can be detected in the body in Yusho patients, a condition caused by ingestion of contaminated rice oil with these compounds. These compounds are excreted out of the body in small amounts directly in the feces from the wall of the intestine. We found the PCDDs, PCDFs and coplanar polychlorinated biphenyls (Co-PCBs) in the sebum of Yusho patients and normal subjects, and there was significant correlation between their concentrations in sebum and blood in both patients and normal control subjects. The concentration of TEQ (toxic equivalent quantity of 2,3,7,8-tetrachlorodibenzo-p-dioxin: TCDD) in sebum of Yusho patients (106 pg/g lipid) was half that in the blood (215 pg/g lipid), while that of normal subjects (29 pg/g lipid) was similar to that in the blood (34 pg/g lipid). On the other hand, in Yusho patients the concentrations of TEQ in the sebum and in blood were 2.3 and 6.4 fold higher than those in normal subjects. We concluded that dioxins and it's related compounds in Yusho patients and normal subjects were excreted not only in the feces but also in the sebum.
Iida
T
T
Fukuoka Institute of Health and Environmental Sciences.
Hirakawa
H
H
Matsueda
T
T
Hori
T
T
Nakao
T
T
Nakayama
J
J
D001572:Benzofurans / Q000032:analysis* / Q000097:blood; D000072338:Dibenzofurans, Polychlorinated; D005506:Food Contamination; D006801:Humans; D012275:Oryza / Q000506:poisoning*; D010938:Plant Oils / Q000506:poisoning*; D011041:Poisoning / Q000378:metabolism; D011078:Polychlorinated Biphenyls / Q000032:analysis* / Q000097:blood / Q000506:poisoning*; D000072317:Polychlorinated Dibenzodioxins / Q000031:analogs & derivatives* / Q000032:analysis / Q000097:blood; D012629:Sebum / Q000737:chemistry*
D001572:Benzofurans; D000072338:Dibenzofurans, Polychlorinated; D010938:Plant Oils; D000072317:Polychlorinated Dibenzodioxins; D011078:Polychlorinated Biphenyls