Effects of single and repeated administration of sulthiame on amygdaloid kindled seizures in rats.
In this study, we assessed the anti-convulsive effects of sulthiame (SUL) in amygdaloid (AM) kindled rats. Electrodes were implanted into the left AM of adult male Wistar rats. The animals were kindled at the after-discharge (AD) threshold. Upon completion of kindling, a generalized seizure triggering threshold was determined. The drugs were administered intraperitoneally in rats which reproducibly exhibited generalized convulsions at the near-threshold stimulation. Single administration of SUL (25-200 mg; n = 7-9) reduced the forelimb clonus (FCL) duration, but only the highest dose significantly regressed the secondarily generalized convulsion. During repeated administration of SUL, 50 mg/kg for 8 days, FCL duration was significantly alleviated until the fifth treatment day. With the dose of 200 mg/kg, significant suppression of secondary generalization was noted only until the second test day. On the other hand, significant reductions of FCL and AD duration were preserved afterwards. The anti-convulsive effects of SUL indicated in this study were not comparable to those of other standard anti-epileptic drugs reported from our laboratory.
Song
H K
HK
National Epilepsy Center, Shizuoka Hospital, Japan.
Hamada
K
K
Yagi
K
K
Seino
M
M
D000679:Amygdala / Q000503:physiopathology*; D000818:Animals; D000927:Anticonvulsants / Q000008:administration & dosage / Q000494:pharmacology*; D004569:Electroencephalography / Q000187:drug effects; D007696:Kindling, Neurologic / Q000187:drug effects / Q000502:physiology*; D008297:Male; D009207:Myoclonus / Q000503:physiopathology; D051381:Rats; D017208:Rats, Wistar; D012640:Seizures / Q000503:physiopathology*; D013843:Thiazines / Q000008:administration & dosage / Q000494:pharmacology*; D000096926:Benzenesulfonamides
D000927:Anticonvulsants; D013843:Thiazines; C084593:sulthiame; D000096926:Benzenesulfonamides