[Effect of inactivated Ebola virus on colony forming activity of human hematopoietic stem cells].
The effect of Ebola virus antigen on the growth of hemopoietic precursors was studied. Incubation of mononuclear cells with the viral antigen led to a dose-dependent decrease of erythroid colony formation but did not alter the growth of the granulocyto-macrophagal precursors. Hence, Ebola virus antigen is capable of directly affecting the hemopoietic activity of precursors in man by inhibiting the growth of erythroid colonies.
Chepurnov
A A
AA
Tiunnikov
G I
GI
Chernukhin
I V
IV
D000956:Antigens, Viral / Q000276:immunology*; D002455:Cell Division; D003114:Colony-Forming Units Assay; D004306:Dose-Response Relationship, Immunologic; D029043:Ebolavirus / Q000276:immunology*; D006412:Hematopoietic Stem Cells / Q000166:cytology* / Q000821:virology; D006801:Humans; D014765:Viral Vaccines / Q000276:immunology*
D000956:Antigens, Viral; D014765:Viral Vaccines