Simian virus 40 T antigen can regulate p53-mediated transcription independent of binding p53.
A simian virus 40 (SV40) T-antigen mutant containing only the N-terminal 136 amino acids, able to bind to Rb and p300 but not p53, partially inhibited p53-mediated transcription without affecting the ability of p53 to bind DNA. These results suggest that SV40 T antigen can regulate p53-mediated transcription either directly through protein-protein association or indirectly through interaction with factors which may function to confer p53-mediated transcription.
Rushton
J J
JJ
Department of Molecular Genetics and Biochemistry, School of Medicine, University of Pittsburgh, Pennsylvania 15261, USA.
Jiang
D
D
Srinivasan
A
A
Pipas
J M
JM
Robbins
P D
PD
D000818:Animals; D000952:Antigens, Polyomavirus Transforming / Q000235:genetics*; D002460:Cell Line; D005786:Gene Expression Regulation; D051379:Mice; D008907:Mink; D014158:Transcription, Genetic; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*
D000952:Antigens, Polyomavirus Transforming; D016159:Tumor Suppressor Protein p53