title: Bone-membrane interface in aseptic loosening of total joint arthroplasties.
abstract: In 19 patients who underwent revision arthroplasty for aseptic loosening of total joint arthroplasty, specimens were taken at the time of operation to include the bone-membrane interface. In 16 (84%) of the specimens, sufficient visualization of the interface was possible to allow histologic interpretation. In 13 of these cases, there was prominent evidence of classic bone remodeling with osteoclast-mediated resorption and active new bone formation. These results suggest that the osteolysis in aseptic loosening is mediated through osteoclastic bone resorption and that the bone found in such areas is extremely active. The findings help to explain the efficacy of impacted morselized bone-graft in the treatment of bone lysis in aseptic loosening.
authors.affiliation: Department of Orthopaedic Surgery, University of Bristol, United Kingdom.
authors.forename: R M
authors.initials: RM
authors.lastname: Atkins
authors.forename: V G
authors.initials: VG
authors.lastname: Langkamer
authors.forename: M J
authors.initials: MJ
authors.lastname: Perry
authors.forename: C J
authors.initials: CJ
authors.lastname: Elson
authors.forename: C M
authors.initials: CM
authors.lastname: Collins
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001862:Bone Resorption / Q000150:complications / Q000473:pathology; D001842:Bone and Bones / Q000473:pathology*; D002462:Cell Membrane / Q000473:pathology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D007595:Joint Prosthesis / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D010006:Osteoblasts / Q000473:pathology; D010010:Osteoclasts / Q000473:pathology; D010020:Osteonecrosis / Q000209:etiology / Q000473:pathology*; D010586:Phagocytes / Q000473:pathology; D011475:Prosthesis Failure; D012189:Retrospective Studies