Supranormal cardiac output in the dopamine- and dobutamine-dependent preterm infant.
To evaluate the incidence of low cardiac output in preterm infants with respiratory distress syndrome (RDS), we measured cardiac output, stroke volume, heart rate, mean arterial blood pressure, and systemic vascular resistance at 8-48 hours of age in 30 preterm infants with RDS who were dependent on inotropic support. We then compared them to 23 normotensive preterm infants with RDS and 27 preterm infants without RDS. RDS infants had a higher cardiac output and lower systemic vascular resistance and blood pressure than infants without RDS. Infants treated with dopamine and dobutamine had a higher cardiac output and heart rate than infants on dopamine alone or the normotensive controls but a lower blood pressure and systemic vascular resistance than the normotensive controls. Supranormal cardiac output (>400 ml/min/kg) was detected in 57% of the infants in the dopamine + dobutamine subgroup (p = 0.009) versus 17% in the normotensive RDS subgroup and 12% in the dopamine subgroup. These data show that high cardiac output is relatively common in infants with RDS dependent on dopamine and dobutamine but is not reflected in the blood pressure.
Lopez
S L
SL
Department of Pediatrics, Martin Luther King Jr./Drew University Medical Center and University of California Los Angeles School of Medicine, Los Angeles, CA 90059, USA.
Leighton
J O
JO
Walther
F J
FJ
D002302:Cardiac Output / Q000187:drug effects* / Q000502:physiology; D002303:Cardiac Output, Low / Q000453:epidemiology* / Q000209:etiology; D002316:Cardiotonic Agents / Q000627:therapeutic use*; D016022:Case-Control Studies; D004280:Dobutamine / Q000627:therapeutic use*; D004298:Dopamine / Q000627:therapeutic use*; D005260:Female; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D007022:Hypotension / Q000188:drug therapy; D015994:Incidence; D007231:Infant, Newborn; D007234:Infant, Premature; D008297:Male; D011663:Pulmonary Surfactants / Q000627:therapeutic use; D012121:Respiration, Artificial; D012127:Respiratory Distress Syndrome, Newborn / Q000503:physiopathology* / Q000628:therapy
D002316:Cardiotonic Agents; D011663:Pulmonary Surfactants; D004280:Dobutamine; D004298:Dopamine