Blind rats are not profoundly impaired in the reference memory Morris water maze and cannot be clearly discriminated from rats with cognitive deficits in the cued platform task.
The Morris water maze is commonly used to test cognitive function in rodent models of neurological disorders including age-related cognitive deficits. It is often assumed that the most profoundly impaired aged rats may be blind due to retinal degeneration, and it has been reported that animals with visual sensory deficits can be identified based on their performance in a cued platform task. The results of the present study demonstrate that blind rats can perform surprisingly well in the reference memory version of the Morris water maze, and that blind rats cannot be selectively excluded based on performance in the cued platform task since atropine-treated rats also perform poorly in the cued platform task. Future studies may be able to develop screening procedures that help to eliminate subjects with non-cognitive deficits, but the present results do not support the use of the cued platform or straight swim task as screening procedures. Experimenters must be careful to consider the role that visual sensory function and other non-cognitive factors may have in performance of the spatial learning Morris water maze, and also the role that severe cognitive deficits may have in performance of the cued platform task.
Lindner
M D
MD
CytoTherapeutics Inc., Providence, RI 02906, USA. MLINDNER@CYTO.COM
Plone
M A
MA
Schallert
T
T
Emerich
D F
DF
D000818:Animals; D001766:Blindness / Q000523:psychology*; D003071:Cognition; D003072:Cognition Disorders / Q000523:psychology*; D003463:Cues; D008297:Male; D018782:Maze Learning; D008568:Memory; D051381:Rats; D017207:Rats, Sprague-Dawley; D013550:Swimming