Human factor-dependent leukemia cell lines.
To date several factor-dependent leukemia cell lines have been established. These cell lines have greatly contributed to the analyses of cytokine-mediated cellular signaling mechanisms involved in cell proliferation, differentiation and survival. In addition, they are ideal and practical models for testing the hypothesis regarding leukemogenesis. Taken together, factor-dependent leukemia cell lines are expected to be useful for studies on cell biology and development of new cancer therapeutics.
Tohyama
K
K
Department of Laboratory Medicine and Clinical Sciences, Graduate School of Medicine, Kyoto University, Japan.
D016207:Cytokines / Q000502:physiology; D006133:Growth Substances / Q000502:physiology*; D006801:Humans; D007938:Leukemia / Q000473:pathology / Q000503:physiopathology; D017978:Receptors, Growth Factor / Q000502:physiology; D015398:Signal Transduction; D014407:Tumor Cells, Cultured
D016207:Cytokines; D006133:Growth Substances; D017978:Receptors, Growth Factor