title: Tripeptide methylketones: synthesis and antiplasmin activity.
abstract: A series of tripeptide methylketones with C-terminal lysine was obtained via Dakin-West method and tested for their antiplasmin activity with the use of antifibrinolytic and antiamidolytic tests. The tripeptide methylketones has been found to inhibit plasmin, however with much lower potency than respective aldehydes.
authors.affiliation: Instytut Chemii, Uniwersytet Warszawski Filia w Białymstoku, Białystok, Poland.
authors.forename: K
authors.initials: K
authors.lastname: Midura-Nowaczek
authors.forename: I
authors.initials: I
authors.lastname: Bruzgo
authors.forename: W
authors.initials: W
authors.lastname: Roszkowska-Jakimiec
authors.forename: K
authors.initials: K
authors.lastname: Worowski
mesh_terms: D055598:Chemical Phenomena; D002627:Chemistry, Physical; D005337:Fibrin / Q000378:metabolism; D005341:Fibrinolysin / Q000037:antagonists & inhibitors*; D005343:Fibrinolytic Agents / Q000138:chemical synthesis / Q000494:pharmacology; D007659:Ketones / Q000138:chemical synthesis* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D010455:Peptides / Q000138:chemical synthesis* / Q000494:pharmacology; D015842:Serine Proteinase Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D005343:Fibrinolytic Agents; D007659:Ketones; D010455:Peptides; D015842:Serine Proteinase Inhibitors; D005337:Fibrin; D005341:Fibrinolysin