Tuberculosis and myelofibrosis in children: a report.
Seven children, six boys and a girl, aged from 2 to 15 years with proven myelofibrosis are reported. The clinical presentation in each of them was more or less similar with weight loss, moderate or low-grade fever, and abdominal distension with pain or discomfort for some months. They had hepatosplenomegaly. The spleens, enlarged to more than 6 cm below the costal margin, were smooth, firm and not tender. There was a variable degree of generalized lymphadenopathy. They were diagnosed as myelofibrosis associated with tuberculosis. The clinical response to anti-tuberculous chemotherapy was remarkable. Extensive search should be made for evidence of tuberculosis in children presenting with myelofibrosis.
Hashim
M S
MS
Department of Paediatrics and Child Health, Faculty of Medicine, University of Khartoum, Sudan.
Kordofani
A Y
AY
el Dabi
M A
MA
D000293:Adolescent; D000995:Antitubercular Agents / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D005260:Female; D006529:Hepatomegaly / Q000150:complications / Q000188:drug therapy; D006801:Humans; D008297:Male; D055728:Primary Myelofibrosis / Q000150:complications* / Q000188:drug therapy; D013163:Splenomegaly / Q000150:complications / Q000188:drug therapy; D016896:Treatment Outcome; D014376:Tuberculosis / Q000150:complications* / Q000188:drug therapy
D000995:Antitubercular Agents