title: Recurrent ulcerations on both legs since early childhood due to a factor V gene mutation.
abstract: We describe the case of a young man who suffered from recurrent ulcerations on both legs since his early childhood as a result of two coagulation factor abnormalities: factor V gene mutation causing microthrombotic occlusions and subsequently ulcerations and an intermittent factor XIII deficiency responsible for retarded wound healing.
authors.affiliation: Department of Dermatology, University Hospital of Freiburg, Germany.
authors.forename: K
authors.initials: K
authors.lastname: Hackenjos
authors.forename: M
authors.initials: M
authors.lastname: Bek
authors.forename: E
authors.initials: E
authors.lastname: Schöpf
authors.forename: W
authors.initials: W
authors.lastname: Vanscheidt
mesh_terms: D000328:Adult; D000925:Anticoagulants / Q000627:therapeutic use; D002648:Child; D005165:Factor V / Q000235:genetics*; D005176:Factor XIII / Q000627:therapeutic use; D005177:Factor XIII Deficiency / Q000150:complications / Q000188:drug therapy; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D007871:Leg Ulcer / Q000188:drug therapy / Q000209:etiology* / Q000235:genetics; D008297:Male; D009154:Mutation / Q000235:genetics*; D011486:Protein C / Q000032:analysis; D012008:Recurrence; D013924:Thrombophlebitis / Q000188:drug therapy / Q000209:etiology / Q000235:genetics; D014945:Wound Healing
chemical_list: D000925:Anticoagulants; D011486:Protein C; D005165:Factor V; D006493:Heparin; D005176:Factor XIII