Postoperative GnRH analog treatment for the prevention of recurrences of uterine myomas after myomectomy. A pilot study.
Sixty-five patients with uterine myomas were studied after surgery to investigate the effect of periodic GnRH analog treatment on the prevention of recurrences. A group of patients was treated by leuprolide acetate depot 3 months a year for 3 years. At the end of treatment, these patients showed a significantly reduced uterine volume and myoma recurrence rate as compared to untreated patients. A role of GnRH analogs in the clinical prevention of myoma recurrence could be suggested.
Vavala
V
V
Department of Obstetrics and Gynecology, Ospedale di Biella, Roma, Italy.
Lanzone
A
A
Monaco
A
A
Scribanti
A
A
Guida
C
C
Mancuso
S
S
D000328:Adult; D003692:Delayed-Action Preparations; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives*; D006801:Humans; D015994:Incidence; D007889:Leiomyoma / Q000453:epidemiology / Q000517:prevention & control* / Q000601:surgery*; D016729:Leuprolide / Q000008:administration & dosage / Q000494:pharmacology*; D009364:Neoplasm Recurrence, Local / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000517:prevention & control*; D010865:Pilot Projects; D011182:Postoperative Care; D014463:Ultrasonography; D014594:Uterine Neoplasms / Q000453:epidemiology / Q000517:prevention & control* / Q000601:surgery*; D014599:Uterus / Q000000981:diagnostic imaging / Q000473:pathology
D003692:Delayed-Action Preparations; D007987:Gonadotropin-Releasing Hormone; D016729:Leuprolide