[Effect of Fe2+ ions on the hemolysis induced by products of psoralen photo-oxidation].
The effects of Fe2+ ions on haemolysis induced by previously photooxidized psoralen (POP-haemolysis) were investigated. It was shown that POP-haemolysis was strongly activated by Fe2+ ions when ferrous ions were added to erythrocytes just after addition of POP. If POP was preincubated with Fe2+ before mixing with erythrocytes, then POP completely lost its ability to induce haemolysis. These data indicate the peroxidic nature of POP products responsible for haemolysis.
Zhuravel'
N N
NN
Belichenko
I V
IV
Kiagova
A A
AA
Lysenko
E P
EP
Khalilov
E M
EM
Potapenko
A Ia
AIa
D005296:Ferrous Compounds / Q000494:pharmacology*; D011564:Furocoumarins / Q000737:chemistry / Q000494:pharmacology*; D006461:Hemolysis / Q000187:drug effects*; D006801:Humans; D066298:In Vitro Techniques; D010084:Oxidation-Reduction; D017319:Photosensitizing Agents / Q000494:pharmacology*
D005296:Ferrous Compounds; D011564:Furocoumarins; D017319:Photosensitizing Agents