in vivo targeting of colloidal carriers by novel graft copolymers.
One of the major obstacles to the targeted delivery of colloidal carriers (nanocapsules) is the body's own defence mechanism in capturing foreign particles by the reticuloendothelial system (RES). This means that following intravenous administration, practically all nanometer size particles are captured by the RES (mainly the liver). This paper draws attention to a recent initiative on the design of 'macromolecular homing devices' which seem to disguise nanoparticles from the RES, and hence are of potential interest for the targeted delivery of nanocapsular carriers. The idea is based on a graft copolymer model embodying a link site for attachment (binding) to the carrier, a floating pad for maintaining the particles afloat in the blood stream, an affinity ligand for site-specific delivery and a structural tune for balancing the overall structure of the homing device. A general synthetic scheme for the preparation of such graft copolymers is given, and preliminary biological evaluations relating to the floating pad concept are discussed.
Arshady
R
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Department of Chemistry, Imperial College of Science, Technology and Medicine, University of London, UK.
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000493:pharmacokinetics; D003102:Colloids; D004337:Drug Carriers; D019833:Genistein; D006801:Humans; D007529:Isoflavones / Q000008:administration & dosage / Q000493:pharmacokinetics; D015394:Molecular Structure; D011108:Polymers
D000970:Antineoplastic Agents; D003102:Colloids; D004337:Drug Carriers; D007529:Isoflavones; D011108:Polymers; D019833:Genistein