Hypertrophic scars, keloids, and contractures. The cellular and molecular basis for therapy.
Keloids, hypertrophic scars, and contractures are a result of aberrations of the normal wound healing process. An understanding of the cellular and molecular events that are implicated in the development of these fibroproliferative disorders will allow for optimization of wound healing. In turn, treatment choices can be based on the most current scientific information available.
Tredget
E E
EE
Department of Surgery, University of Alberta, Edmonton, Canada.
Nedelec
B
B
Scott
P G
PG
Ghahary
A
A
D000328:Adult; D002648:Child; D017439:Cicatrix, Hypertrophic / Q000209:etiology / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D003286:Contracture / Q000209:etiology / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D016207:Cytokines / Q000502:physiology*; D005260:Female; D005347:Fibroblasts / Q000378:metabolism; D006801:Humans; D007372:Interferons / Q000502:physiology*; D007627:Keloid / Q000209:etiology / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D008232:Lymphoproliferative Disorders / Q000517:prevention & control; D008297:Male
D016207:Cytokines; D007372:Interferons