Changes in iron, calcium, magnesium, copper, and zinc levels in different tissues of riboflavin-deficient rats.
To clarify the changes of mineral levels in different tissues of riboflavin-deficient rats, Wistar rats were separated into three groups. One group was fed a diet ad libitum that was deficient in riboflavin. The other two were fed either the complete diet that was weight-matched to the riboflavin-deficient group or fed a complete diet ad libitum. In riboflavin-deficient rats, the hemoglobin concentration and riboflavin contents of blood, liver, and kidney were significantly decreased, compared with weight-matched and ad libitum-fed controls. The mineral concentrations of tissues are summarized as follows: The iron (Fe) concentration in the heart, liver, and spleen was decreased in the riboflavin-deficient group compared with the other groups. Calcium (Ca) and magnesium (Mg) concentrations in tibia were decreased in the riboflavin-deficient group compared with the other two groups. Copper (Cu) concentration was increased in the heart and liver, when the riboflavin-deficient group was compared with the other groups. Zinc (Zn) concentration was increased in tibia when the riboflavin-deficient group was compared with the other groups.
Chen
H
H
Department of Social Medicine, Graduate School of Medicine, Kyoto University, Japan.
Kimura
M
M
Itokawa
Y
Y
D000818:Animals; D001835:Body Weight; D002118:Calcium / Q000378:metabolism*; D003300:Copper / Q000378:metabolism; D004435:Eating; D007501:Iron / Q000378:metabolism; D008274:Magnesium / Q000378:metabolism*; D008297:Male; D009929:Organ Size; D009928:Organ Specificity; D051381:Rats; D017208:Rats, Wistar; D012257:Riboflavin Deficiency / Q000378:metabolism*; D014018:Tissue Distribution; D014131:Trace Elements / Q000378:metabolism*; D015032:Zinc / Q000378:metabolism
D014131:Trace Elements; D003300:Copper; D007501:Iron; D008274:Magnesium; D015032:Zinc; D002118:Calcium