title: Identification of a chick homologue of Fringe and C-Fringe 1: involvement in the neurogenesis and the somitogenesis.
abstract: In Drosophila, Serrate plays an important role to the wing margin formation. A putative secretory protein, Fringe, is indispensable for the wing margin formation inducing Serrate and other genes. Recently, Xenopus homologues of Fringe were identified and one of them, lunatic Fringe (X-lFng), was demonstrated to be involved in mesoderm induction. We have identified two chick Fringe homologous genes by reverse transcription-polymerase chain reaction and cDNA library screening. One of them, C-Fringe 1, showed sequence similarity to X-lFng. In situ hybridization study of C-Fringe 1 has demonstrated its expression in the developing nervous system and in the presomitic mesoderm. The hindbrain and spinal cord showed the distinct stripe pattern expression which was complementary to that of C-Serrate, indicating the correlation between them in vertebrate.
authors.affiliation: Department of Oral Pathology, Faculty of Dentistry, Graduate School of Dentistry, Tokyo Medical and Dental University, Bunkyo-ku, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Sakamoto
authors.forename: L
authors.initials: L
authors.lastname: Yan
authors.forename: H
authors.initials: H
authors.lastname: Imai
authors.forename: M
authors.initials: M
authors.lastname: Takagi
authors.forename: Y
authors.initials: Y
authors.lastname: Nabeshima
authors.forename: S
authors.initials: S
authors.lastname: Takeda
authors.forename: K
authors.initials: K
authors.lastname: Katsube
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D030161:Avian Proteins; D001483:Base Sequence; D002642:Chick Embryo; D003001:Cloning, Molecular; D018076:DNA, Complementary; D029721:Drosophila Proteins; D018507:Gene Expression Regulation, Developmental; D016695:Glycosyltransferases; D019476:Insect Proteins / Q000235:genetics*; D008969:Molecular Sequence Data; D017351:N-Acetylglucosaminyltransferases; D009420:Nervous System / Q000196:embryology*; D011506:Proteins / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics; D019170:Somites / Q000166:cytology*
chemical_list: D030161:Avian Proteins; D018076:DNA, Complementary; D029721:Drosophila Proteins; D019476:Insect Proteins; D011506:Proteins; D012333:RNA, Messenger; D016695:Glycosyltransferases; C498394:LFNG protein, Gallus gallus; D017351:N-Acetylglucosaminyltransferases; C090576:fng protein, Drosophila