Chlamydia trachomatis growth stimulates interleukin 8 production by human monocytic U-937 cells.
Growth of Chlamydia trachomatis serotypes L2 and L3 in a human monocytic cell line, U-937, increased the rate of interleukin 8 (IL-8) release 100-fold. Heat-killed chlamydiae induced a 10-fold-lower level of production of IL-8. IL-8 may play an important role in the inflammatory reaction to chlamydial infection.
Bianchi
A
A
Laboratoire de Bactériologie-Virologie-Hygiène, Hôpital Saint-Louis,Université Paris VII, France.
Dosquet
C
C
Henry
S
S
Couderc
M C
MC
Ferchal
F
F
Scieux
C
C
D002460:Cell Line; D002692:Chlamydia trachomatis / Q000502:physiology*; D006801:Humans; D016209:Interleukin-8 / Q000096:biosynthesis*; D009000:Monocytes / Q000382:microbiology / Q000502:physiology*
D016209:Interleukin-8