17 beta-(3-furyl)-5 beta-androstane-3 beta, 14 beta, 17 alpha-triol (PST 2238). A very potent antihypertensive agent with a novel mechanism of action.
Quadri
L
L
Department of Medicinal Chemistry, Prassis Istituto di Ricerche Sigma-Tau, Settimo Milanese (MI), Italy.
Bianchi
G
G
Cerri
A
A
Fedrizzi
G
G
Ferrari
P
P
Gobbini
M
M
Melloni
P
P
Sputore
S
S
Torri
M
M
D000732:Androstanols / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D000959:Antihypertensive Agents / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D001794:Blood Pressure / Q000187:drug effects; D004791:Enzyme Inhibitors; D006973:Hypertension / Q000188:drug therapy; D007700:Kinetics; D015394:Molecular Structure; D010042:Ouabain / Q000378:metabolism / Q000494:pharmacology; D051381:Rats; D011922:Rats, Mutant Strains; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors / Q000378:metabolism
D000732:Androstanols; D000959:Antihypertensive Agents; D004791:Enzyme Inhibitors; D010042:Ouabain; D000254:Sodium-Potassium-Exchanging ATPase; C106263:rostafuroxin