title: Effects of neocortical implants of cobalt and other seizure-inducing metals on brain C-14 2-deoxyglucose uptake.
abstract: Nine days after insertion of a pure cobalt metal rod into the visual cortex, regions of increased 2-DG uptake are observed both in relatively normal Nissl-staining tissue lying around the implant site and in the connecting dorsal lateral geniculate nucleus of the thalamus. These hypermetabolic regions have been claimed to be the metabolic 'signatures' of tissue made epileptogenic by the cobalt. The present study showed, however, that while the 'dark patches' develop following posterior cortex implants, they do not appear after anterior cortex cobalt implants. Moreover, the dark patches were not detectable after cortical implants of other seizure-inducing metals such as antimony and nickel. These new findings indicate that the dark patches occur too idiosyncratically to make them the metabolic 'signatures' of tissue made epileptic by cobalt.
authors.affiliation: Psychology Department, University of Calgary, AB, Canada. rmcooper@acs.ucalgary.ca
authors.forename: R M
authors.initials: RM
authors.lastname: Cooper
authors.forename: C
authors.initials: C
authors.lastname: Legare
mesh_terms: D000818:Animals; D001345:Autoradiography; D001923:Brain Chemistry / Q000187:drug effects*; D003035:Cobalt / Q000008:administration & dosage / Q000494:pharmacology*; D003292:Convulsants / Q000008:administration & dosage / Q000494:pharmacology*; D003847:Deoxyglucose / Q000378:metabolism*; D004343:Drug Implants; D008297:Male; D008670:Metals / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D013788:Thalamus / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D014793:Visual Cortex / Q000187:drug effects / Q000473:pathology / Q000502:physiology*
chemical_list: D003292:Convulsants; D004343:Drug Implants; D008670:Metals; D003035:Cobalt; D003847:Deoxyglucose