Electroconvulsive shock increases the phosphorylation of cyclic AMP response element binding protein at Ser-133 in rat hippocampus but not in cerebellum.
ECS increased the Ser-133 phosphorylation of CREB in rat hippocampus, but not in the cerebellum, even though the basal level of phosphorylated CREB was higher in cerebellum. These results indicate that c-fos induction after ECS may be mediated by Ser-133 phosphorylation of CREB in rat hippocampus, but not in the cerebellum.
Jeon
S H
SH
Department of Biochemistry, Seoul National University College of Medicine, Korea.
Seong
Y S
YS
Juhnn
Y S
YS
Kang
U G
UG
Ha
K S
KS
Kim
Y S
YS
Park
J B
JB
D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism*; D002531:Cerebellum / Q000378:metabolism*; D000242:Cyclic AMP / Q000378:metabolism*; D004597:Electroshock; D006624:Hippocampus / Q000378:metabolism*; D008297:Male; D010766:Phosphorylation; D016760:Proto-Oncogene Proteins c-fos / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D012694:Serine / Q000378:metabolism*
D002352:Carrier Proteins; D016760:Proto-Oncogene Proteins c-fos; D012694:Serine; D000242:Cyclic AMP