title: In-vitro activity of carbapenem antibiotics against beta-lactam susceptible and resistant strains of Burkholderia pseudomallei.
abstract: Four carbapenem antibiotics were tested for their in-vitro activities (MICs, MBCs and time-kill studies) against Burkholderia pseudomallei. The carbapenems were all more active than either ceftazidime or co-amoxiclav against strains of B. pseudomallei with a normal susceptibility pattern. Biapenem was the most active antibiotic tested. All four carbapenems retained bactericidal activity against 24 strains of B. pseudomallei with reduced susceptibility to ceftazidime and/or co-amoxiclav.
authors.affiliation: Mahidol University, Bangkok, Thailand.
authors.forename: M D
authors.initials: MD
authors.lastname: Smith
authors.forename: V
authors.initials: V
authors.lastname: Wuthiekanun
authors.forename: A L
authors.initials: AL
authors.lastname: Walsh
authors.forename: N J
authors.initials: NJ
authors.lastname: White
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D016957:Burkholderia pseudomallei / Q000187:drug effects*; D015780:Carbapenems / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D018440:beta-Lactam Resistance
chemical_list: D000900:Anti-Bacterial Agents; D015780:Carbapenems