Protection of the infant thyroid from radioactive contamination by the administration of stable iodide. An experimental evaluation in chimpanzees.
Protection of the thyroid from radioactive contamination by the administration of stable iodide was investigated in chimpanzees aged 2 to 98 weeks. The uptake of iodide in the thyroid was measured with 123I-. The animals were subjected to a control measurement first, and subsequently the thyroid uptake of 123I- was determined twice; once at the start and once at the end of 11 days of ingestion of 0.5, 1.5 or 5.0 mg of stable iodide per kg body weight per day. The three doses of iodide reduced the control thyroid iodide uptake of 10 to 30% to lower than 1% when ingested 1 h before exposure to the tracer and to 2-4% when ingested 20 h before exposure. In the latter experiments 0.5 mg iodide/kg was less effective than doses of 1.5 mg/kg or higher. The physiological state of the thyroid of control infant chimpanzees does not differ from that of human infants. Incidentally, an increased level of TSH was found during the ingestion of iodide, but with unaltered thyroxine levels. Therefore, it is concluded that a daily dose of 1.5 mg stable iodide/kg body weight and higher offers optimal protection of the thyroid against exposure to radioactive iodine in infants and that, when used during 10 days, it leaves the thyroid unaffected.
Noteboom
J L
JL
Comprehensive Cancer Center, Rotterdam, The Netherlands.
Hummel
W A
WA
Broerse
J J
JJ
de Vijlder
J J
JJ
Vulsma
T
T
van Bekkum
D W
DW
D000818:Animals; D007457:Iodine Radioisotopes / Q000378:metabolism / Q000493:pharmacokinetics*; D002679:Pan troglodytes; D011193:Potassium Iodide / Q000494:pharmacology*; D011835:Radiation Protection; D013961:Thyroid Gland / Q000528:radiation effects*; D013972:Thyrotropin / Q000097:blood
D007457:Iodine Radioisotopes; D011193:Potassium Iodide; D013972:Thyrotropin