title: Aortitis, aortic valve incompetence, and left coronary ostium stenosis in a patient with C-ANCA-associated necrotizing vasculitis.
abstract: Aortitis with involvement of the aortic valve is rarely associated with vasculitis syndromes. We present a patient with antibodies to a neutrophil cytoplasmic antigen-associated (ANCA) vasculitis with renal failure who developed aortic incompetence as a result of aortitis which involved the aortic valve. Thickening of the aortic wall also caused stenosis of the left coronary ostium.
authors.affiliation: Department of Cardiothoracic Surgery, St. Antonius Hospital, Nieuwegein, The Netherlands.
authors.forename: W J
authors.initials: WJ
authors.lastname: Morshuis
authors.forename: C J
authors.initials: CJ
authors.lastname: Zeebregts
authors.forename: H C
authors.initials: HC
authors.lastname: Haanen
authors.forename: J R
authors.initials: JR
authors.lastname: Elbers
authors.forename: J M
authors.initials: JM
authors.lastname: Ernst
authors.forename: F E
authors.initials: FE
authors.lastname: Vermeulen
mesh_terms: D019268:Antibodies, Antineutrophil Cytoplasmic / Q000276:immunology*; D001022:Aortic Valve Insufficiency / Q000150:complications* / Q000601:surgery; D001025:Aortitis / Q000150:complications*; D003327:Coronary Disease / Q000150:complications* / Q000601:surgery; D003937:Diagnosis, Differential; D006801:Humans; D008297:Male; D008875:Middle Aged; D009336:Necrosis; D051437:Renal Insufficiency / Q000150:complications* / Q000473:pathology; D018366:Vasculitis, Leukocytoclastic, Cutaneous / Q000150:complications* / Q000175:diagnosis / Q000276:immunology
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic