title: Calculation by microdosimetric methods of the formation by a single high-energy photon or electron of two lesions in the same DNA molecule.
abstract: The formation by a single high-energy photon or electron of two lesions (such as double-strand breaks) in the same DNA molecule is calculated by microdosimetric methods. The result is similar to a previous calculation using a target theory approach. Thus, it is reasonably certain that, for > or = 1 Gy of sparsely ionizing radiation acting on a DNA molecule of > or = 10(6) base pairs, < or = 3% of two-hit events such as deletions are from a single radiation event.
authors.affiliation: Department of Therapeutic Radiology, Yale University, New Haven, CT 06520-8040, USA.
authors.forename: F
authors.initials: F
authors.lastname: Hutchinson
mesh_terms: D004247:DNA / Q000528:radiation effects*; D004249:DNA Damage; D004583:Electrons; D017785:Photons; D011829:Radiation Dosage
chemical_list: D004247:DNA