[Development and study of immunoglobulins against Lassa fever].
The authors validate the use of horses as producers of immune antiserum to Lassa virus. Specific immunoglobulin with at least 1:512 titer of virus neutralizing antibodies to Lassa virus was obtained from the serum of immunized horses by Kohn's alcohol method. The resultant preparation does not differ from the heterologous commercial immunoglobulins. Preclinical studies of immunoglobulin against Lassa virus demonstrated its safety and high specific activity. The strategy of treating with the immunoglobulin alone and in combination with virasol has been experimentally validated.
Krasniaskiĭ
V P
VP
Gradoboev
V N
VN
Borisevich
I V
IV
Potryvaeva
N V
NV
Lebedinskaia
E V
EV
Chernikova
N K
NK
Timan'kova
G D
GD
D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis* / Q000276:immunology; D000998:Antiviral Agents / Q000627:therapeutic use; D018050:Arenavirus / Q000276:immunology*; D018049:Arenaviruses, Old World / Q000276:immunology; D002460:Cell Line; D002522:Chlorocebus aethiops; D006736:Horses; D007106:Immune Sera; D007116:Immunization, Passive; D007136:Immunoglobulins / Q000096:biosynthesis* / Q000276:immunology; D007835:Lassa Fever / Q000276:immunology* / Q000628:therapy; D012254:Ribavirin / Q000627:therapeutic use
D000914:Antibodies, Viral; D000998:Antiviral Agents; D007106:Immune Sera; D007136:Immunoglobulins; D012254:Ribavirin