[Angioedema of the mucous membranes of the upper aerodigestive tract after administration of ACE inhibitors].
Inhibitors of angiotensin converting enzyme may rarely cause an angioneurotic oedema of the upper aerodigestive tract. The pathomechanism of this side effect depends on an interaction of the drug with hormones regulating the vascular resistance such as the kallikrein kinin system and the prostaglandin system. Anglo-oedema is characterised by subcutaneous or submucosal swelling, which preferably affects the lips, the soft palate, the tongue and the larynx. Pathomechanisms, differential diagnosis and treatment of ACE-inhibitor induced oedema of the upper aerodigestive tract are described by means of 3 case reports.
Tisch
M
M
Abteilung Hals-Nasen-Ohren-Heilkunde, Kopf- und Halschirurgie, Bundewehrkrankenhaus Ulm.
Maier
H
H
D000402:Airway Obstruction / Q000139:chemically induced*; D000799:Angioedema / Q000139:chemically induced*; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000008:administration & dosage / Q000009:adverse effects*; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000009:adverse effects*; D002216:Captopril / Q000008:administration & dosage / Q000009:adverse effects; D003680:Deglutition Disorders / Q000139:chemically induced*; D004656:Enalapril / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D017706:Lisinopril / Q000008:administration & dosage / Q000009:adverse effects; D008297:Male; D008875:Middle Aged
D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D004656:Enalapril; D002216:Captopril; D017706:Lisinopril