title: Systemic arterial dirofilariasis in five dogs.
abstract: Systemic arterial dirofilariasis is an unusual manifestation of heartworm disease of dogs that results from aberrant migration of Dirofilaria immitis into the peripheral arterial circulation. To expand the clinical characterization of systemic arterial dirofilariasis, 5 dogs evaluated at the North Carolina State University's College of Veterinary Medicine were reviewed. Common clinical presentations included hindlimb lameness, paresthesia of hindlimbs, and interdigital ischemic necrosis resulting from thromboembolic disease. Visualization of heartworms with angiography or ultrasonography confirmed the diagnosis in all cases. All 5 dogs were treated with an adulticide; 3 dogs were treated with thiacetasamide sodium and 2 with melarsomine dihydrochloride. Four of the 5 dogs survived the initial treatment period; 1 dog died of severe thromboembolic complications after thiacatarsamide sodium therapy. The treatment of systemic arterial dirofilariasis creates a therapeutic challenge because of multiple potential complications resulting from thromboembolic disease.
authors.affiliation: Department of Clinical Studies, Ontario Veterinary College, University of Guelph, Canada.
authors.forename: J R
authors.initials: JR
authors.lastname: Frank
authors.forename: F B
authors.initials: FB
authors.lastname: Nutter
authors.forename: A E
authors.initials: AE
authors.lastname: Kyles
authors.forename: C E
authors.initials: CE
authors.lastname: Atkins
authors.forename: R K
authors.initials: RK
authors.lastname: Sellon
mesh_terms: D000818:Animals; D001148:Arsenamide / Q000627:therapeutic use; D001152:Arsenicals / Q000627:therapeutic use; D001158:Arteries / Q000469:parasitology / Q000473:pathology; D004184:Dirofilariasis / Q000188:drug therapy* / Q000473:pathology; D004283:Dog Diseases / Q000188:drug therapy / Q000469:parasitology* / Q000473:pathology; D004285:Dogs; D005369:Filaricides / Q000627:therapeutic use; D008297:Male; D014227:Triazines / Q000627:therapeutic use
chemical_list: D001152:Arsenicals; D005369:Filaricides; D014227:Triazines; C076253:melarsomine; D001148:Arsenamide