[Effects of amitriptyline on the contractile function of the myocardium. Dobutrex in the role of a positive inotropic agent].
Study of the effect of a tricyclic antidepressant amitriptyline on an isolated papillary muscle of the rat left ventricle showed a decrease of the contractility due to depression of the potential of action and the slow calcium channels, as well as decreased rate and prolongation of contraction caused by impairment of calcium reabsorption from the sarcoplasma. Injection of dobutrex after amitriptyline has a positive inotropic effect by completely removing the disorders in the time parameters of contraction.
Meledin
V Iu
VIu
Antiuf'ev
V F
VF
Mashanov
G I
GI
D000639:Amitriptyline / Q000494:pharmacology*; D000818:Animals; D000929:Antidepressive Agents, Tricyclic / Q000494:pharmacology*; D002316:Cardiotonic Agents / Q000494:pharmacology*; D004280:Dobutamine / Q000494:pharmacology*; D066298:In Vitro Techniques; D008955:Models, Cardiovascular; D009200:Myocardial Contraction / Q000187:drug effects*; D010210:Papillary Muscles / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar
D000929:Antidepressive Agents, Tricyclic; D002316:Cardiotonic Agents; D000639:Amitriptyline; D004280:Dobutamine