title: Polyunsaturated fat in the diet may improve intestinal function in patients with Crohn's disease.
abstract: To investigate the effect of increasing dietary polyunsaturated fat intake on fat absorption in Crohn's patients, normal subjects and subjects with inactive Crohn's disease consumed a high polyunsaturated to saturated fat ratio diet. Subjects participated in breath tests before and after six months of a high polyunsaturated to saturated (P/S) fat ratio diet to measure their response to [1-13C] 10:0 and [1-13C] 16:0 ingested with a test meal. Whole body absorption-oxidation of C10:0 was not affected by the diet treatment. Before diet treatment, whole body absorption-oxidation of C16:0 in Crohn's patients was 80% of that observed for control subjects. After consuming a high polyunsaturated to saturated fatty acid ratio diet, subjects increased oxidation of C16:0 by 85% compared to before the diet treatment period. It is concluded that (1) absorption of labelled C16:0 from a test meal is reduced in Crohn's patients, and (2) consumption of a high polyunsaturated to saturated fatty acid ratio diet improves the utilization of dietary C16:0 by Crohn's patients.
authors.affiliation: Nutrition and Metabolism Research Group, University of Alberta, Edmonton, Canada.
authors.forename: M A
authors.initials: MA
authors.lastname: French
authors.forename: A M
authors.initials: AM
authors.lastname: Parrott
authors.forename: E S
authors.initials: ES
authors.lastname: Kielo
authors.forename: R V
authors.initials: RV
authors.lastname: Rajotte
authors.forename: L C
authors.initials: LC
authors.lastname: Wang
authors.forename: A B
authors.initials: AB
authors.lastname: Thomson
authors.forename: M T
authors.initials: MT
authors.lastname: Clandinin
mesh_terms: D001835:Body Weight; D001944:Breath Tests; D003424:Crohn Disease / Q000178:diet therapy* / Q000503:physiopathology; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage*; D005227:Fatty Acids / Q000378:metabolism; D005527:Food, Fortified; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects*
chemical_list: D004042:Dietary Fats, Unsaturated; D005227:Fatty Acids