Intracellular targeting, interaction with Src homology 3 (SH3) domains and rolipram-detected conformational switches in cAMP-specific PDE4A phosphodiesterase.
Houslay
M D
MD
Division of Biochemistry & Molecular Biology, IBLS, University of Glasgow, Scotland, U.K.
Scotland
G
G
Erdogan
S
S
Huston
E
E
Mackenzie
S
S
McCallum
J F
JF
McPhee
I
I
Pooley
L
L
Rena
G
G
Ross
A
A
Beard
M
M
Peder
A
A
Begg
F
F
Wilkinson
I
I
Yarwood
S
S
Ackerman
C
C
Houslay
E S
ES
Hoffman
R
R
Engels
P
P
Sullivan
M
M
Bolger
G
G
D015105:3',5'-Cyclic-AMP Phosphodiesterases; D017398:Alternative Splicing; D000595:Amino Acid Sequence; D000818:Animals; D002878:Chromosomes, Human, Pair 1; D002895:Chromosomes, Human, Pair 5; D000242:Cyclic AMP / Q000378:metabolism; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4; D006801:Humans; D007527:Isoenzymes / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000235:genetics; D007700:Kinetics; D008969:Molecular Sequence Data; D005810:Multigene Family; D010726:Phosphodiesterase Inhibitors / Q000494:pharmacology*; D010727:Phosphoric Diester Hydrolases / Q000737:chemistry* / Q000235:genetics* / Q000378:metabolism; D011487:Protein Conformation; D011760:Pyrrolidinones / Q000494:pharmacology*; D051381:Rats; D020889:Rolipram; D018909:src Homology Domains
D007527:Isoenzymes; D010726:Phosphodiesterase Inhibitors; D011760:Pyrrolidinones; D000242:Cyclic AMP; D010727:Phosphoric Diester Hydrolases; D015105:3',5'-Cyclic-AMP Phosphodiesterases; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4; C517355:PDE4A protein, human; D020889:Rolipram