title: [Pathologic humeral fracture in secondary osteosarcoma of the humerus: a rare complication of osteodystrophia deformans Paget].
abstract: Pathological fracture in histologically proven post-Paget osteosarcoma of the humerus is a rare complication. Due to individual requests as well as age and comorbidity, a course of primary palliative treatment was chosen in the present case. Survival time after diagnosis was 9 months and the patient died of a tumor-independent disease. Even in combined treatment, consisting of surgery and (neo-)adjuvant radio-/chemotherapy, prognosis of osteosarcomas secondary to Paget's disease remains very disappointing. Therefore, in treatment of this highly lethal tumor the patient's individual requests and personal situation often require more consideration than in many other malignancies.
authors.affiliation: Abteilung für Unfall- und Wiederherstellungschirurgie, Universitätskrankenhaus Hamburg-Eppendorf, in Zusammenarbeit mit dem Zentrum für Biomechanik des UKE.
authors.forename: A
authors.initials: A
authors.lastname: Katzer
authors.forename: W D
authors.initials: WD
authors.lastname: Beecken
authors.forename: N M
authors.initials: NM
authors.lastname: Meenen
authors.forename: K H
authors.initials: KH
authors.lastname: Jungbluth
authors.forename: G
authors.initials: G
authors.lastname: Delling
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001859:Bone Neoplasms / Q000473:pathology / Q000628:therapy*; D003131:Combined Modality Therapy; D005260:Female; D005598:Fractures, Spontaneous / Q000473:pathology / Q000628:therapy*; D006801:Humans; D006811:Humerus / Q000473:pathology; D018447:Medical Futility; D010001:Osteitis Deformans / Q000473:pathology / Q000628:therapy*; D012516:Osteosarcoma / Q000473:pathology / Q000628:therapy*