title: Phase I study of direct administration of a replication deficient adenovirus vector containing the E. coli cytosine deaminase gene to metastatic colon carcinoma of the liver in association with the oral administration of the pro-drug 5-fluorocytosine.
authors.affiliation: Rockefeller University Hospital, New York, New York 10021, USA.
authors.forename: R G
authors.initials: RG
authors.lastname: Crystal
authors.forename: E
authors.initials: E
authors.lastname: Hirschowitz
authors.forename: M
authors.initials: M
authors.lastname: Lieberman
authors.forename: J
authors.initials: J
authors.lastname: Daly
authors.forename: E
authors.initials: E
authors.lastname: Kazam
authors.forename: C
authors.initials: C
authors.lastname: Henschke
authors.forename: D
authors.initials: D
authors.lastname: Yankelevitz
authors.forename: N
authors.initials: N
authors.lastname: Kemeny
authors.forename: R
authors.initials: R
authors.lastname: Silverstein
authors.forename: A
authors.initials: A
authors.lastname: Ohwada
authors.forename: T
authors.initials: T
authors.lastname: Russi
authors.forename: A
authors.initials: A
authors.lastname: Mastrangeli
authors.forename: A
authors.initials: A
authors.lastname: Sanders
authors.forename: J
authors.initials: J
authors.lastname: Cooke
authors.forename: B G
authors.initials: BG
authors.lastname: Harvey
mesh_terms: D000256:Adenoviridae / Q000235:genetics*; D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000963:Antimetabolites / Q000627:therapeutic use*; D003110:Colonic Neoplasms / Q000473:pathology; D043525:Cytosine Deaminase; D004926:Escherichia coli / Q000201:enzymology / Q000235:genetics; D005260:Female; D005437:Flucytosine / Q000627:therapeutic use*; D015316:Genetic Therapy; D005822:Genetic Vectors; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary / Q000628:therapy*; D008297:Male; D009700:Nucleoside Deaminases / Q000235:genetics; D011355:Prodrugs / Q000627:therapeutic use*; D014779:Virus Replication / Q000235:genetics
chemical_list: D000963:Antimetabolites; D011355:Prodrugs; D005437:Flucytosine; D009700:Nucleoside Deaminases; D043525:Cytosine Deaminase