Amine precursor amino acid therapy: from neurochemical basis to clinical aspects.
The particulars regarding the amine precursor therapy for treatment of neuropsychiatric disorders and their neurochemical background are described historically. Furthermore, peculiar or artificial amino acids which are metabolized into the brain amine or their derivatives and promised their clinical application are also introduced.
Nakajima
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Department of Neuropsychiatry, Kyoto Perfectural University of Medicine, Kawaramachi-Hirokoji, Kamigyoku, Kyoto, Japan.
D006916:5-Hydroxytryptophan / Q000627:therapeutic use; D000596:Amino Acids / Q000627:therapeutic use*; D000818:Animals; D003866:Depressive Disorder / Q000188:drug therapy*; D015103:Droxidopa / Q000627:therapeutic use; D006639:Histidine / Q000031:analogs & derivatives / Q000627:therapeutic use; D006801:Humans; D007980:Levodopa / Q000627:therapeutic use; D010300:Parkinson Disease / Q000188:drug therapy*
D000596:Amino Acids; D007980:Levodopa; D006639:Histidine; D006916:5-Hydroxytryptophan; D015103:Droxidopa