title: [Amiodarone-induced thyrotoxicosis cured by thyroidectomy].
abstract: We report a case of amiodarone-induced thyrotoxicosis, diagnosed with a systematic laboratory investigation in a 64-year-old patient, for haematuria. Despite the interruption of amiodarone, hyperthyroidism and a goiter occurred. Conventional therapy betablockers, antithyroid agents, prednisone, potassium perchlorate) did not result in any clinical improvement. The development of a malignant thyrotoxicosis with neurologic disturbances and acute respiratory insufficiency required mechanical ventilation and a subtotal thyroidectomy. The patient's status improved progressively and he was discharged without sequelae. The respective roles of medical therapy and thyroidectomy in amiodarone-induced thyrotoxicosis are discussed.
authors.affiliation: Département d'anesthésie-réanimation B, CHU hôpital Nord, Amiens, France.
authors.forename: P
authors.initials: P
authors.lastname: Le Cosquer
authors.forename: A M
authors.initials: AM
authors.lastname: Guerin-Robardey
authors.forename: M
authors.initials: M
authors.lastname: Ossart
mesh_terms: D000638:Amiodarone / Q000009:adverse effects* / Q000627:therapeutic use; D000889:Anti-Arrhythmia Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001282:Atrial Flutter / Q000188:drug therapy; D002312:Cardiomyopathy, Hypertrophic / Q000188:drug therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D013965:Thyroidectomy; D013971:Thyrotoxicosis / Q000139:chemically induced* / Q000628:therapy; D013974:Thyroxine / Q000097:blood; D016896:Treatment Outcome
chemical_list: D000889:Anti-Arrhythmia Agents; D000638:Amiodarone; D013974:Thyroxine