Efficacy of hyperthermia and polyunsaturated fatty acids on experimental carcinoma.
We investigated the efficacy of hyperthermia and gamma-linolenic acid on experimental carcinoma. This study focused on polyunsaturated fatty acids that are substrates for free radical reactions. Oleic acid, linolenic acid, alpha-linolenic acid, or gamma-linolenic acid was injected into the arteries feeding AH109A carcinoma implanted into rat hind limbs. Among these, gamma-linolenic acid had the greatest effect on tumor tissue lipid peroxidation and demonstrated an antitumor effect. Consequently, gamma-linolenic acid injection into the feeding artery of a tumor was performed immediately prior to hyperthermia. This combination therapy induced a high level of lipid peroxidation in tumor tissue and a significant antitumor effect. Hyperthermia combined with gamma-linolenic acid produces free radical reactions by increasing the radical reaction substrate and may be an effective anticancer modality.
Kokura
S
S
First Department of Internal Medicine, Kyoto Prefectural University of Medicine, Kamigyo-ku, Japan.
Yoshikawa
T
T
Kaneko
T
T
Iinuma
S
S
Nishimura
S
S
Matsuyama
K
K
Naito
Y
Y
Yoshida
N
N
Kondo
M
M
D000818:Animals; D002277:Carcinoma / Q000378:metabolism / Q000628:therapy*; D005231:Fatty Acids, Unsaturated / Q000494:pharmacology*; D006979:Hyperthermia, Induced; D015227:Lipid Peroxidation; D008297:Male; D009368:Neoplasm Transplantation; D019301:Oleic Acid / Q000008:administration & dosage / Q000494:pharmacology; D051381:Rats; D014810:Vitamin E / Q000494:pharmacology; D017962:alpha-Linolenic Acid / Q000008:administration & dosage / Q000494:pharmacology; D017965:gamma-Linolenic Acid / Q000008:administration & dosage / Q000494:pharmacology
D005231:Fatty Acids, Unsaturated; D017962:alpha-Linolenic Acid; D014810:Vitamin E; D019301:Oleic Acid; D017965:gamma-Linolenic Acid