title: Changes in cerebral blood flow accompanied with reduction of blood pressure treatment in patients with hypertensive intracerebral hemorrhages.
abstract: Blood pressure usually is reduced in patients with hypertensive intracerebral hemorrhage for the prevention of the expansion of the hematoma and recurrent hemorrhage in acute stage. However, disturbed autoregulation of cerebral circulation is expected, and decreased cerebral blood flow (CBF) caused by excessive hypotension has been pointed out. There are different mechanisms of action in hypotensives, thereby the influence of hypotension on CBF in patients with the thalamic hemorrhage was investigated using nitroglycerin (TNG), diltiazem hydrochloride (DH) and trimethaphan camsilate (TC). Average CBF in a hemisphere on the hematoma side, the hemisphere without hematoma, and around the hematoma showed a slight decline after administration of TNG or DH. However, CBF declined more, after TC than DH. DH and TNG are preferable in descending order to control blood pressure of patients with intracerebral hemorrhage in the acute stages in view of a smaller decline in CBF.
authors.affiliation: Department of Neurosurgery, Iwate Medical University, Morioka, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Kuroda
authors.forename: N
authors.initials: N
authors.lastname: Kuwata
authors.forename: N
authors.initials: N
authors.lastname: Sato
authors.forename: M
authors.initials: M
authors.lastname: Funayama
authors.forename: A
authors.initials: A
authors.lastname: Yabuta
authors.forename: S
authors.initials: S
authors.lastname: Taguchi
authors.forename: M
authors.initials: M
authors.lastname: Suzuki
authors.forename: A
authors.initials: A
authors.lastname: Takahashi
authors.forename: A
authors.initials: A
authors.lastname: Ogawa
mesh_terms: D000328:Adult; D000368:Aged; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001794:Blood Pressure; D002543:Cerebral Hemorrhage / Q000209:etiology* / Q000503:physiopathology*; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D004110:Diltiazem / Q000627:therapeutic use; D006406:Hematoma / Q000209:etiology / Q000503:physiopathology; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000188:drug therapy* / Q000503:physiopathology; D008875:Middle Aged; D005996:Nitroglycerin / Q000627:therapeutic use; D013786:Thalamic Diseases / Q000209:etiology / Q000503:physiopathology; D014294:Trimethaphan / Q000627:therapeutic use
chemical_list: D000959:Antihypertensive Agents; D014294:Trimethaphan; C017774:trimethaphan camsylate; D004110:Diltiazem; D005996:Nitroglycerin