[Modification of the DNA spatial structure when complexed with cisplatin].
The experimental and theoretical analyses of the conformational transitions of DNA-cis-platinum complexes have been carried out. It is shown that at low concentrations of the ligand, the thermodynamic parameters of the helix-coil transition of the complexes are not the result of the local B-->A transition.
Arutiunina
S G
SG
Florence University, Italy.
Mamasakhlisov
E Sh
ESh
Morozov
V F
VF
Dalian
E B
EB
Khachikian
R E
RE
Vardevanian
P O
PO
Orioli
P
P
Bruni
B
B
D000818:Animals; D002417:Cattle; D002945:Cisplatin / Q000737:chemistry*; D004247:DNA / Q000737:chemistry*; D018736:DNA Adducts / Q000737:chemistry*; D008956:Models, Chemical; D009690:Nucleic Acid Conformation; D013816:Thermodynamics
D018736:DNA Adducts; C057270:cisplatin-DNA adduct; D004247:DNA; D002945:Cisplatin