Dysfunction of the endothelial nitric oxide signalling pathway in diabetes and hyperglycaemia.
1. Vasodilatation induced by adenosine is mediated through the activation of A2-purinoceptors in endothelial and smooth muscle cells. 2. Adenosine induces a rapid and transient membrane hyperpolarization in endothelial cells. 3. Acute exposure to adenosine or A2-purinoceptor agonists activates the L-arginine-NO signalling pathway in human endothelial cells in vitro.
Sobrevia
L
L
Vascular Biology Research Centre, King's College London, UK. lsobrev@halcon.dpi.udec.cl
Mann
G E
GE
D003920:Diabetes Mellitus / Q000503:physiopathology*; D004730:Endothelium, Vascular / Q000503:physiopathology*; D006801:Humans; D006943:Hyperglycemia / Q000503:physiopathology*; D009569:Nitric Oxide / Q000502:physiology*; D015398:Signal Transduction
D009569:Nitric Oxide