Murine model of rotavirus infection.
The murine model of homologous rotavirus infection has been used to study the determinants of protection. The local IgA immune response appears to be the critical factor in generating protective immunity after natural infection. A series of knockout mice were used to evaluate the contribution of T cells and B cells to immunity and resolution from primary infection. Both arms of immune system played a role in the resolution of primary infection but antibody was much more important for prevention of reinfection.
Feng
N
N
Department of Microbiology and Immunology, School of Medicine, Stanford University, California 94305, USA.
Franco
M A
MA
Greenberg
H B
HB
D000818:Animals; D000833:Animals, Suckling / Q000382:microbiology; D000914:Antibodies, Viral / Q000276:immunology; D000956:Antigens, Viral / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000502:physiology; D004195:Disease Models, Animal; D007070:Immunoglobulin A / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D016513:Mice, SCID; D012400:Rotavirus Infections / Q000276:immunology*
D000914:Antibodies, Viral; D000956:Antigens, Viral; D004268:DNA-Binding Proteins; D007070:Immunoglobulin A; C499308:Rag2 protein, mouse; C064655:V(D)J recombination activating protein 2