title: Correlation of transrectal ultrasonography and core biopsies with pathology results in radical prostatectomy specimens.
abstract: BACKGROUND
  We compared preoperative tumor location, as identified by transrectal ultrasonography (TRUS), and TRUS-guided core biopsies with the final histopathological examination of radical prostatectomy specimens.
  
  
  METHODS
  Thirty patients who had radical retropubic prostatectomy after evaluation with TRUS are included in the study. Diagnosis of prostate cancer was established with TRUS-guided systematic (3 cores from base, mid and apex of the peripheral zone, and 1 core from the transition zone of each side of the prostate) and lesion-directed core biopsies in all cases. Each prostate gland was halved for histopathological examination and results are reported in terms of "sides".
  
  
  RESULTS
  Histopathological examination of the prostatectomy specimens revealed prostate cancer bilaterally in 29 glands (58 sides) and unilaterally in 1 gland. Preprostatectomy TRUS examinations missed cancer in 29 sides, and core biopsies were negative for cancer in 14 sides.
  
  
  CONCLUSIONS
  This study revealed that 49% of prostate cancer lesions (n = 29 sides) were not recognized on TRUS and 52% of those (n = 15 sides) were diagnosed only by additional systematic biopsies. Furthermore, even with TRUS-guided systematic core biopsies, failure to detect the prostate cancer lesions may be as high as 24% (n = 14 sides).
authors.affiliation: Department of Urology, Marmara University School of Medicine, Istanbul, Turkey.
authors.forename: L
authors.initials: L
authors.lastname: Türkeri
authors.forename: T
authors.initials: T
authors.lastname: Tarcan
authors.forename: T
authors.initials: T
authors.lastname: Biren
authors.forename: S
authors.initials: S
authors.lastname: Küllü
authors.forename: A
authors.initials: A
authors.lastname: Akdaş
mesh_terms: D001706:Biopsy; D006801:Humans; D008297:Male; D011237:Predictive Value of Tests; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology* / Q000601:surgery; D012007:Rectum; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014463:Ultrasonography