Effect of the sulfonylurea glyburide on superoxide dismutase in streptozotocin-induced diabetic rat muscle.
1. The effect of glyburide (glibenclamide) treatment on the muscle superoxide dismutase (SOD) activity of diabetic rats has been studied. 2. Four weeks of treatment with glyburide (5 mg/kg, orally) increased muscle SOD activity and decreased blood glucose levels. 3. The results of this study demonstrate that the sulfonylurea, glyburide, is capable of exerting direct insulin-like effects on muscle SOD activity in vivo.
Altan
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N
Department of Biochemistry, Faculty of Medicine, University of Gazi, Beşevler, Ankara, Turkey.
Yiğit
S
S
Elmali
E
E
Malhatun
E
E
Rota
S
S
Kiliç
N
N
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy / Q000201:enzymology* / Q000503:physiopathology; D003924:Diabetes Mellitus, Type 2 / Q000201:enzymology; D005905:Glyburide / Q000494:pharmacology*; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D008297:Male; D018482:Muscle, Skeletal / Q000187:drug effects* / Q000201:enzymology; D051381:Rats; D013482:Superoxide Dismutase / Q000378:metabolism*
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D013482:Superoxide Dismutase; D005905:Glyburide