Cellular consequences of the association of apoB lipoproteins with proteoglycans. Potential contribution to atherogenesis.
Many of the discussed results come from empirical experiments performed with in vitro models whose relevance to the complex environment of the intima is limited. However, they are consistent with the line of reasoning that intima PGs interact specifically with apoB lipoproteins and contribute to their retention. This could provide the residence time and the initial alterations of the lipoproteins that favor their further modifications by oxidative processes and hydrolytic enzymes. Products of such modifications, and the modified particles, may be stimuli for changes in the functionality of endothelium, smooth muscle cells, and macrophages. The focal synthesis of PGs with high affinity for apoB lipoproteins could make the phenomena chronic. Clinical and laboratory studies indicate that dense LDL, poor in surface polar lipids, is associated with an atherogenic phenotype. Particles with these properties may contribute to the disease via its high affinity for arterial PGs. This affinity can be modulated by diet, lifestyle, and lipid-lowering drugs.
Hurt-Camejo
E
E
Wallenberg Laboratory for Cardiovascular Research, Faculty of Medicine, University of Gothenburg, Sweden.
Olsson
U
U
Wiklund
O
O
Bondjers
G
G
Camejo
G
G
D000595:Amino Acid Sequence; D000818:Animals; D001055:Apolipoproteins B / Q000378:metabolism*; D001161:Arteriosclerosis / Q000503:physiopathology*; D006801:Humans; D007477:Ions; D008077:Lipoproteins, LDL / Q000378:metabolism*; D008969:Molecular Sequence Data; D011509:Proteoglycans / Q000378:metabolism*; D017539:Tunica Intima / Q000378:metabolism*
D001055:Apolipoproteins B; D007477:Ions; D008077:Lipoproteins, LDL; D011509:Proteoglycans