title: Histologic study of a shielded macula.
abstract: OBJECTIVE
  To illustrate the histologic changes at the macula of an eye shielded from focused light for 76 years. Age-related macular degeneration with a central, subretinal, fibrous scar was present in the fellow eye.
  
  
  METHODS
  Autopsy examination of both eyes of a 91-year-old man was performed. The superior half of the macular area of the shielded eye was studied by light microscopy, and the inferior half was studied by electron microscopy. Serial sections through the macular area of the fellow eye were prepared and studied.
  
  
  RESULTS
  The shielded eye contained basal laminar deposits up to 6.0 microns in thickness and basal linear deposits up to 1.0 micron in thickness in the macular area. The photoreceptor outer and inner segments of the outer nuclear layer were intact. The macular area of the fellow eye contained a two-component, vascularized, disciform scar that measured up to 250 microns in one area, with retinal pigment epithelial tears at the nasal and temporal margins. Extensive photoreceptor layer atrophy was present.
  
  
  CONCLUSIONS
  Such marked asymmetry of macular degeneration in this case may be further evidence of the role of light exposure in the development of age related macular degeneration.
authors.affiliation: Eye Pathology Laboratory, Johns Hopkins Hospital, Baltimore, Maryland 21287-9248, USA.
authors.forename: J B
authors.initials: JB
authors.lastname: Harlan
authors.forename: D T
authors.initials: DT
authors.lastname: Weidenthal
authors.forename: W R
authors.initials: WR
authors.lastname: Green
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002386:Cataract / Q000150:complications; D002387:Cataract Extraction; D002921:Cicatrix / Q000473:pathology; D005355:Fibrosis / Q000473:pathology; D005451:Fluorescein Angiography; D005500:Follow-Up Studies; D005654:Fundus Oculi; D006801:Humans; D017075:Laser Coagulation; D008027:Light; D008266:Macula Lutea / Q000473:pathology* / Q000528:radiation effects* / Q000648:ultrastructure; D008268:Macular Degeneration / Q000209:etiology / Q000473:pathology / Q000601:surgery; D008297:Male; D010786:Photoreceptor Cells / Q000473:pathology* / Q000528:radiation effects / Q000648:ultrastructure; D014821:Vitrectomy