title: Lack of behavioural risk factors for squamous intraepithelial lesions (SIL) in HIV-infected women.
abstract: HIV-infected women have a high prevalence of abnormal Papanicolaou smears and cervical intraepithelial neoplasia. A multiparametric analysis of epidemiological and behavioural risk factors has been performed in a cohort of 204 HIV-infected women in an outpatient clinic with the aim to investigate risk factors associated with squamous intraepithelial lesions (SIL) in HIV-seropositive women. The prevalence of SIL in the study population was 35.7%. Univariate and multivariate analysis of demographic, behavioural and immunological variables only identified cigarette smoking > 20/day and CD4+ cell counts < or = 200 x 10(6)/L as risk factors significantly associated with SIL in the study population. We found no epidemiological/behavioural risk factors specifically associated with SIL in HIV-infected women as compared with the general population. The results suggest that the high prevalence of SIL in HIV disease is related to acquired immune deficiency in HIV-seropositive women.
authors.affiliation: Service d'Immunologie, INSERM U 430, Hôpital Broussais, Paris, France.
authors.forename: I
authors.initials: I
authors.lastname: Heard
authors.forename: D
authors.initials: D
authors.lastname: Jeannel
authors.forename: C
authors.initials: C
authors.lastname: Bergeron
authors.forename: M
authors.initials: M
authors.lastname: Saada
authors.forename: R
authors.initials: R
authors.lastname: Henrion
authors.forename: M D
authors.initials: MD
authors.lastname: Kazatchkine
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000328:Adult; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D012307:Risk Factors; D012309:Risk-Taking; D012725:Sexual Behavior; D002583:Uterine Cervical Neoplasms / Q000150:complications* / Q000453:epidemiology* / Q000276:immunology; D002578:Uterine Cervical Dysplasia / Q000150:complications* / Q000453:epidemiology* / Q000276:immunology