title: Perfusion of the subfoveal choriocapillaris affects visual recovery after submacular surgery in presumed ocular histoplasmosis syndrome.
abstract: OBJECTIVE
  To determine the relationship between the visual result and perfusion of the subfoveal choriocapillaris after surgical excision of subfoveal neovascularization in presumed ocular histoplasmosis syndrome.
  
  
  METHODS
  We reviewed the records of 38 eyes of 37 patients with gradable postoperative fluorescein angiograms and color photographs after surgical excision of a subfoveal neovascular membrane in presumed ocular histoplasmosis syndrome. The postoperative photographs and fluorescein angiograms were graded in a masked fashion for the presence of perfusion of the subfoveal choriocapillaris. We used preoperative and postoperative best-corrected visual acuities to determine the correlation between postoperative perfusion of the subfoveal choriocapillaris and both final visual acuity and visual improvement after surgery.
  
  
  RESULTS
  After surgery, the subfoveal choriocapillaris was perfused in 24 of the 38 eyes (63%) and nonperfused in 14 (37%). Best-corrected visual acuity improved by at least 2 Snellen lines in 17 of the 24 perfused eyes (71%) and two of the 14 nonperfused eyes (14%) (P = .0089). Best-corrected visual acuity of 20/100 or better was achieved in 18 of the perfused eyes (75%) and four nonperfused eyes (29%) (P = .0076).
  
  
  CONCLUSIONS
  Both final visual acuity and improvement in visual acuity were correlated with postoperative perfusion of the subfoveal choriocapillaris in patients with presumed occular histoplasmosis syndrome. Development of techniques to maintain or reestablish perfusion of the subfoveal choriocapillaris after surgery may improve visual outcome in these eyes.
authors.affiliation: Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Missouri 63110-1096, USA.
authors.forename: L
authors.initials: L
authors.lastname: Akduman
authors.forename: L V
authors.initials: LV
authors.lastname: Del Priore
authors.forename: V N
authors.initials: VN
authors.lastname: Desai
authors.forename: R J
authors.initials: RJ
authors.lastname: Olk
authors.forename: H J
authors.initials: HJ
authors.lastname: Kaplan
mesh_terms: D002196:Capillaries / Q000473:pathology / Q000503:physiopathology; D002829:Choroid / Q000098:blood supply*; D005123:Eye / Q000382:microbiology*; D005451:Fluorescein Angiography; D005584:Fovea Centralis; D006660:Histoplasmosis / Q000503:physiopathology* / Q000601:surgery*; D006801:Humans; D008266:Macula Lutea / Q000601:surgery*; D009389:Neovascularization, Pathologic / Q000601:surgery; D011184:Postoperative Period; D014785:Vision, Ocular; D014792:Visual Acuity