title: Identification of ovine herpesvirus-2 infection in sheep.
abstract: A polymerase chain reaction test for the detection of ovine herpesvirus-2 (OHV-2) DNA was used to identify sites of OHV-2 infection in peri-natal lambs and in adult sheep. OHV-2 was detected in the nasal secretions from all lambs within a period of two months following birth. Subsequently, OHV-2 DNA was identified in a number of epithelial tissues including the cornea, turbinates and pharynx. In addition, OHV-2 DNA was detected exclusively in B-lymphocytes from six of ten adult sheep tested. An infection cycle for OHV-2 in sheep is proposed which bears similarities with the gammaherpesviruses Epstein-Barr virus and mouse herpesvirus-68.
authors.affiliation: Moredun Research Institute, Edinburgh, U.K.
authors.forename: S I
authors.initials: SI
authors.lastname: Baxter
authors.forename: A
authors.initials: A
authors.lastname: Wiyono
authors.forename: I
authors.initials: I
authors.lastname: Pow
authors.forename: H W
authors.initials: HW
authors.lastname: Reid
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000821:virology; D004279:DNA, Viral; D006564:Herpesviridae / Q000235:genetics / Q000302:isolation & purification*; D006566:Herpesviridae Infections / Q000175:diagnosis* / Q000662:veterinary / Q000821:virology; D009297:Nasal Mucosa / Q000378:metabolism / Q000821:virology; D009693:Nucleic Acid Hybridization; D012756:Sheep; D012757:Sheep Diseases / Q000175:diagnosis* / Q000821:virology
chemical_list: D004279:DNA, Viral