Synchronization processes in the mechanisms of short-term memory in monkeys: the involvement of cholinergic and glutaminergic cortical structures.
Behavioral experiments were carried out in which monkeys had to solve a task involving delayed visual discrimination, and activity was simultaneously recorded from several neurons of the visual, prefrontal, and lower temporal regions of the cortex before and after modification of cholinergic (by systemic infusion of the M-cholinoceptor blocker amizil) and glutaminergic (by intracortical perfusion with glutaminergic agonists and antagonists, i.e., NMDA, aminophosphonovalerianic acid (APV) and aminophosphonobutyric acid (APB)) systems. Amizil and APV reduced the duration of short-term information retention and increased the delay before the motor response was made. Worsening of these parameters was accompanied by a significant level of desynchronization of activity in the groups of neurons studied. NMDA and APB improved short-term memory and increased neuron synchronization. The role of synchronization of information processes in the mechanisms of short-term memory and the involvement of the cholinergic and glutaminergic systems are discussed.
Dudkin
K N
KN
Laboratory for the Regulation of Brain Neuron Function, I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg.
Kruchinin
V K
VK
Chueva
I V
IV
D000613:Aminobutyrates / Q000008:administration & dosage / Q000494:pharmacology; D000818:Animals; D002540:Cerebral Cortex / Q000502:physiology*; D018680:Cholinergic Antagonists / Q000008:administration & dosage / Q000494:pharmacology; D004192:Discrimination, Psychological / Q000502:physiology; D018690:Excitatory Amino Acid Agonists / Q000008:administration & dosage / Q000494:pharmacology; D018698:Glutamic Acid / Q000502:physiology*; D007267:Injections; D008253:Macaca mulatta; D008570:Memory, Short-Term / Q000502:physiology*; D009474:Neurons / Q000502:physiology; D010275:Parasympathetic Nervous System / Q000502:physiology*; D017397:Prefrontal Cortex / Q000166:cytology / Q000502:physiology; D013702:Temporal Lobe / Q000166:cytology / Q000502:physiology; D014793:Visual Cortex / Q000166:cytology / Q000502:physiology
D000613:Aminobutyrates; D018680:Cholinergic Antagonists; D018690:Excitatory Amino Acid Agonists; D018698:Glutamic Acid; C012729:2-amino-4-phosphonobutyric acid