Inhibition by TGF-beta 1 of the in vitro thymulin-stimulated proliferation of gonocytes from fetal rat testes.
The cytokine transforming growth factor beta 1 (TGF-beta 1) inhibits the growth of certain cells and the differentiation of others. A thymus hormone, thymulin, stimulated the proliferation of fetal male germ cells in explants of testes from 13.5 gestation day rat fetuses. The way in which thymulin acts is unknown. Adding TGF-beta 1 to the culture medium blocked the response of the fetal male rat germ cells to thymulin. We suggest that TGF-beta 1 and thymulin may thus influence the same metabolic chain of events.
Prépin
J
J
Département de cytologie et histologie, université Paris V-René-Descartes, France.
Le Vigouroux
P
P
D000818:Animals; D002455:Cell Division / Q000187:drug effects*; D005865:Gestational Age; D008297:Male; D009924:Organ Culture Techniques; D051381:Rats; D017208:Rats, Wistar; D013094:Spermatozoa / Q000166:cytology*; D013737:Testis / Q000166:cytology* / Q000196:embryology*; D013935:Thymic Factor, Circulating / Q000494:pharmacology*; D016212:Transforming Growth Factor beta / Q000494:pharmacology*
D016212:Transforming Growth Factor beta; D013935:Thymic Factor, Circulating