title: The use of selective serotonin reuptake inhibitors for depression and psychosis complicating dementia.
abstract: This retrospective chart review examines the impact of selective serotonin reuptake inhibitors on 20 patients with both depression and psychosis complicating dementia of the Alzheimer type (DAT) and other dementias. Fifteen of the 20 patients had moderate to marked improvement in depressive and psychotic symptoms. Eleven of 12 patients with DAT had moderate to marked improvement compared to only four of eight patients with dementia from other causes. The drugs were effective in diminishing or eliminating psychotic symptoms in six patients who had previously not responded to a trial of a neuroleptic. The selective serotonin reuptake inhibitors may have an important role to play in patients with DAT who have coexisting depression and psychosis. These drugs are very well tolerated and may have a place as first-line agents in non-emergent settings where a clinician might otherwise think of instituting a neuroleptic or as a second-line agent when a neuroleptic has proven ineffective.
authors.affiliation: Creighton-Nebraska Department of Psychiatry, University of Nebraska Medical Center, Omaha, USA. wjburke@unmc.edu
authors.forename: W J
authors.initials: WJ
authors.lastname: Burke
authors.forename: V
authors.initials: V
authors.lastname: Dewan
authors.forename: S P
authors.initials: SP
authors.lastname: Wengel
authors.forename: W H
authors.initials: WH
authors.lastname: Roccaforte
authors.forename: G C
authors.initials: GC
authors.lastname: Nadolny
authors.forename: D G
authors.initials: DG
authors.lastname: Folks
mesh_terms: D015057:1-Naphthylamine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000150:complications; D003704:Dementia / Q000150:complications*; D003866:Depressive Disorder / Q000188:drug therapy* / Q000209:etiology; D005260:Female; D006801:Humans; D008297:Male; D017374:Paroxetine / Q000627:therapeutic use*; D011618:Psychotic Disorders / Q000188:drug therapy* / Q000209:etiology; D012189:Retrospective Studies; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use*; D020280:Sertraline
chemical_list: D015057:1-Naphthylamine; D017374:Paroxetine; D017367:Selective Serotonin Reuptake Inhibitors; D020280:Sertraline