[Effect of an antioxidant (ubiquinone Q-9) and chronic low-dose irradiation on rat chromatin structure and T-lymphocyte proliferation].
We have demonstrated the protective effect of natural antioxidant coenzyme Q-9 on the T-cell proliferative capacity and chromosomal DNA state under low dose chronic irradiation. The DNA-staining fluorescent dye Hoechst-33258 and acridine orange were to observed the nuclear morphology changes in T-lymphocytes. Ubiquinone diet partially restored the decreasing in immune response and the luminescence intensity of DNA-Hoechst-33258 complex in T-cells of low dose irradiated rats.
Novoselova
E G
EG
Gordon
R Ia
RIa
Semiletova
N V
NV
Karnaukhov
V N
VN
D000165:Acridine Orange / Q000737:chemistry; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D006690:Bisbenzimidazole / Q000737:chemistry; D002455:Cell Division / Q000187:drug effects / Q000528:radiation effects; D002478:Cells, Cultured; D002843:Chromatin / Q000187:drug effects* / Q000528:radiation effects*; D005456:Fluorescent Dyes / Q000737:chemistry; D049449:Luminescence; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013050:Spectrometry, Fluorescence; D013601:T-Lymphocytes / Q000187:drug effects* / Q000276:immunology / Q000528:radiation effects*; D014451:Ubiquinone / Q000494:pharmacology*
D000975:Antioxidants; D002843:Chromatin; D005456:Fluorescent Dyes; D014451:Ubiquinone; D000165:Acridine Orange; D006690:Bisbenzimidazole; C030571:ubiquinone 9