[The nature of hematopoiesis in animals with experimentally depressed immune system: natural and bifidumbacterin-induced recovery].
An attempt was made to examine the regulatory effect of bifidumbacterin on the recovery of immunological and hemopoietic homeostasis in mice. Bifidumbacterin feeding to healthy animals had no effect, except for the below-normal values reaching the statistically mean characteristic of mice of this strain. Bifidumbacterin stimulated lymphoiesis in animals immunocompromized by the administration of antilymphocytic antibodies or radiation, but the values being no higher than the normal ones. The same action was seen with erythropoiesis during postradiation loss of red blood cells. The activation or suppression of erythro- or myelopoiesis, which was not caused by direct damage to these cellular populations, but which occurred with the activation of nonspecific T helpers or T suppressors in impairments or recovery of the count of circulating mature lymphocytes under the action of bifidumbacterin, was blocked.
Fedorova
I M
IM
NII of Epidemiology and Microbiology of GN Gabrichevskiĭ, Moscow.
Bliakher
M S
MS
Nilovskiĭ
M N
MN
Kapustin
I V
IV
D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology*; D001688:Biological Products / Q000494:pharmacology*; D004195:Disease Models, Animal; D006410:Hematopoiesis / Q000187:drug effects* / Q000502:physiology; D007108:Immune Tolerance / Q000187:drug effects* / Q000276:immunology; D007109:Immunity / Q000187:drug effects / Q000528:radiation effects; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D012074:Remission Induction
D000890:Anti-Infective Agents; D001688:Biological Products; C010546:bifidobacterin