In utero and lactational exposure of carbofuran to rats: effect on testes and sperm.
Male offspring of adult females treated with 0.2 or 0.4 mg/kg during either the whole of pregnancy or the whole of the lactation period did not induce generalised toxic effects. A significant alteration in enzymatic activities i.e. SDH (decreased), LDH and Y-GT (increased) were observed in testes only at 0.4 mg/kg. A decrease in sperm motility, sperm count along with increase in percent abnormal sperm was observed at 0.4 mg/kg dose level. Histopathological examination revealed loss of spermato-genesis, degenerative changes in Sertoli cells which are well supported with biochemical studies indicating that carbofuran interferes with the maturation process of testis. No such effects were observed at 0.2 mg/kg. The testicular and spermatotoxic effects observed in rats given in utero or lactational exposure may be due to transfer of carbofuran or its metabolites through placenta or mothers milk.
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Industrial Toxicology Research Centre, Lucknow, India.
Shankar
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R
Srivastava
S P
SP
D000818:Animals; D000833:Animals, Suckling; D002235:Carbofuran / Q000633:toxicity*; D002800:Cholinesterase Inhibitors / Q000633:toxicity*; D005260:Female; D007306:Insecticides / Q000633:toxicity*; D007064:L-Iditol 2-Dehydrogenase / Q000378:metabolism; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D007774:Lactation; D008297:Male; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D013081:Sperm Motility / Q000187:drug effects; D013094:Spermatozoa / Q000166:cytology / Q000187:drug effects* / Q000502:physiology; D013737:Testis / Q000187:drug effects* / Q000201:enzymology / Q000473:pathology; D005723:gamma-Glutamyltransferase / Q000378:metabolism
D002800:Cholinesterase Inhibitors; D007306:Insecticides; D007064:L-Iditol 2-Dehydrogenase; D007770:L-Lactate Dehydrogenase; D005723:gamma-Glutamyltransferase; D002235:Carbofuran