A flow cytometric study of early gastric cancer. The detection of high proliferative activity adds important information to the prognosis.
The prognostic value of DNA ploidy and proliferative activity has been rarely investigated in early gastric carcinoma (EGC). In the present study the ploidy pattern and cell cycle related parameters were evaluated in formalin-fixed paraffin-embedded specimens of 71 followed-up EGCs and compared with that of 20 advanced gastric carcinomas (AGC) using flow cytometry. The results showed that ploidy pattern did not affect patient outcome. On the contrary, EGC with a high S-phase had a worse prognosis. No significant differences in proliferative activity were detected between EGC and AGC. Fatal EGC had an S-phase higher than AGC. In conclusion, proliferative activity seems to affect the prognosis of EGC independent of the stage and could contribute to the identification of aggressive types of EGC.
Ranaldi
R
R
Institute of Pathological Anatomy and Histopathology, University of Ancona, Italy.
Santinelli
A
A
Fabris
G
G
Mannello
B
B
Natoli
C
C
Tinari
N
N
Bearzi
I
I
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002455:Cell Division; D005260:Female; D005434:Flow Cytometry; D016193:G1 Phase; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011003:Ploidies; D011379:Prognosis; D016192:Resting Phase, Cell Cycle; D016196:S Phase; D013274:Stomach Neoplasms / Q000175:diagnosis*