Systemic lupus erythmatosus associated with autoimmune hepatitis two cases with novel autoantibodies to transfer RNA-related antigens.
Two cases of systemic lupus erythematosus (SLE) with autoimmune hepatitis are reported. Both patients had a mild form of SLE without central nervous system or renal involvement and showed a rapid response to corticosteroid therapy. Neither of them had antibodies to mitochondria, smooth muscle, and liver/kidney microsome-1 related to autoimmune hepatitis. Instead, novel autoantibodies which react with transfer RNA-related antigen were detected. These autoantibodies could be a useful marker for classification of SLE associated with autoimmune hepatitis.
Satoh
T
T
Department of Internal Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.
Hirakata
M
M
Yoshida
T
T
Matsumura
M
M
Miyachi
K
K
Mimori
T
T
Akizuki
M
M
D000328:Adult; D001323:Autoantibodies / Q000032:analysis*; D001327:Autoimmune Diseases / Q000150:complications* / Q000175:diagnosis / Q000276:immunology; D015415:Biomarkers / Q000097:blood; D003937:Diagnosis, Differential; D005260:Female; D006521:Hepatitis, Chronic / Q000150:complications* / Q000175:diagnosis / Q000276:immunology; D006801:Humans; D008099:Liver / Q000276:immunology / Q000473:pathology; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000175:diagnosis / Q000276:immunology; D012343:RNA, Transfer / Q000276:immunology*
D001323:Autoantibodies; D015415:Biomarkers; D012343:RNA, Transfer