title: Detection of myocardial viability using stress echocardiography.
abstract: Asynergic myocardial regions in patients with coronary artery disease can be viable. They may have the ability to improve their function after restoring coronary blood flow. Asynergic but viable myocardial regions have a positive inotropic reserve which can be stimulated by catecholamines. Because echocardiography is an established method for evaluating regional left ventricular function, it has the potential to detect the inotropic response of asynergic myocardial regions. In the clinical setting, prediction of left ventricular functional improvement after revascularization is particularly important. Dobutamine stress echocardiography is the most frequently used stress echocardiographic test for detection of myocardial viability. Dobutamine is infused at low rates of 2.5 to 20 micrograms.kg-1.min-1 to detect myocardial viability. This paper reports on the sensitivity and specificity of the method for the detection of viability and its usefulness for prediction of left ventricular functional improvement after revascularization.
authors.affiliation: Wuppertal Heart Centre, Department of Cardiology, Germany.
authors.forename: W
authors.initials: W
authors.lastname: Krahwinkel
authors.forename: T
authors.initials: T
authors.lastname: Ketteler
authors.forename: J
authors.initials: J
authors.lastname: Wolfertz
authors.forename: J
authors.initials: J
authors.lastname: Gödke
authors.forename: I
authors.initials: I
authors.lastname: Krakau
authors.forename: L J
authors.initials: LJ
authors.lastname: Ulbricht
authors.forename: W
authors.initials: W
authors.lastname: Mecklenbeck
authors.forename: H
authors.initials: H
authors.lastname: Gülker
mesh_terms: D000328:Adult; D000368:Aged; D002316:Cardiotonic Agents; D004280:Dobutamine; D004452:Echocardiography / Q000379:methods*; D005080:Exercise Test / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis*; D017682:Myocardial Stunning / Q000175:diagnosis*; D009206:Myocardium / Q000473:pathology; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity; D016277:Ventricular Function, Left / Q000502:physiology
chemical_list: D002316:Cardiotonic Agents; D004280:Dobutamine