A study to determine whether serum follicle-stimulating hormone can be a marker for ovarian hyperresponse to follicle-maturing drugs for in vitro fertilization.
The study presented herein evaluated whether 26 of 122 consecutive women who tend to hyper-respond (serum estradiol >4,000 pg/ml or >30 follicles) following controlled ovarian hyperstimulation for in vitro fertilization have higher serum FSH levels at certain critical stages during the follicular phase. Baseline day-2 serum FSH and blood levels taken on days 5 and 6 of human menopausal gonadotropin therapy were not different in the hyper-responders from those responding normally. The only significant difference in serum FSH was seen on the day of human chorionic gonadotropin where it was actually lower in the hyper-responders. Thus, there does not appear to be a critical serum FSH level which would dictate a decrease in gonadotropins to prevent hyper-response.
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J H
JH
Department of Obstetrics and Gynecology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School at Camden, and Cooper Hospital/University Medical Center, USA.
Pesso
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Peymer
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D000328:Adult; D015415:Biomarkers / Q000097:blood; D006063:Chorionic Gonadotropin / Q000494:pharmacology; D004797:Enzyme-Linked Immunosorbent Assay; D004958:Estradiol / Q000097:blood; D005260:Female; D005300:Fertility Agents, Female / Q000008:administration & dosage / Q000494:pharmacology*; D005307:Fertilization in Vitro / Q000379:methods*; D005640:Follicle Stimulating Hormone / Q000097:blood*; D006801:Humans; D007279:Injections, Subcutaneous; D016729:Leuprolide / Q000008:administration & dosage / Q000494:pharmacology*; D007986:Luteinizing Hormone / Q000097:blood; D008596:Menotropins / Q000008:administration & dosage / Q000494:pharmacology*; D006080:Ovarian Follicle / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000502:physiology; D016471:Ovarian Hyperstimulation Syndrome / Q000097:blood* / Q000139:chemically induced / Q000453:epidemiology; D010062:Ovulation Induction; D012307:Risk Factors; D014463:Ultrasonography
D015415:Biomarkers; D006063:Chorionic Gonadotropin; D005300:Fertility Agents, Female; D004958:Estradiol; D008596:Menotropins; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D016729:Leuprolide