The past, present and future of transgenic bioreactors.
Hybrid genes can control the tissue-specific synthesis of human proteins in transgenic animals. Thus, it is now possible to produce proteins of biomedical value in the body fluids or cells of transgenic livestock. In fact, the first transgenically produced protein, antithrombin III, is now in clinical trials and others will soon follow.
Drohan
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J. Holland Laboratory, American Red Cross, Rockville, MD, USA. drohan@usa.redcross.org
D000818:Animals; D030801:Animals, Genetically Modified; D019149:Bioreactors; D001798:Blood Proteins / Q000096:biosynthesis / Q000235:genetics*; D005544:Forecasting; D006801:Humans; D011499:Protein Processing, Post-Translational; D011994:Recombinant Proteins / Q000096:biosynthesis
D001798:Blood Proteins; D011994:Recombinant Proteins