Effect of coconut palm wine (Toddy) on carbohydrate metabolism in pregnant rats and fetuses.
The objective of this study was to determine the effects of an alcoholic beverage (Toddy) and the equivalent quantity of ethanol on carbohydrate metabolism in utero. Female rats were exposed to Toddy from coconut palm (24.5 ml/kg body weight/day) and ethanol (0.52 ml/kg body weight/day) for 15 days before conception and throughout gestation. On the 19th day of gestation, hypoglycemia was seen in both the treated groups, but it was more in the Toddy-treated group. Synthesis of glycogen was elevated on exposure to ethanol/Toddy but its degradation was enhanced only in alcohol-exposed rats. Key enzymes of citric acid cycle and gluconeogenesis were inhibited on administration of both alcohol and Toddy. Activity of glycolytic enzymes were increased. Toddy seemed to potentiate the toxicity induced by alcohol, indicating the additive effects of congeners.
Lal
J J
JJ
Department of Biochemistry, University of Kerala, Kariyavattom, Trivandrum, India.
Kumar
C V
CV
Suresh
M V
MV
Indira
M
M
Vijayammal
P L
PL
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D050260:Carbohydrate Metabolism; D002952:Citric Acid Cycle; D004357:Drug Synergism; D004791:Enzyme Inhibitors; D000431:Ethanol / Q000009:adverse effects; D005260:Female; D005333:Fetus / Q000187:drug effects; D005943:Gluconeogenesis; D006003:Glycogen / Q000096:biosynthesis; D008099:Liver / Q000187:drug effects / Q000196:embryology / Q000378:metabolism; D011247:Pregnancy; D051381:Rats; D015431:Weight Loss; D014920:Wine / Q000009:adverse effects*
D001786:Blood Glucose; D004791:Enzyme Inhibitors; D000431:Ethanol; D006003:Glycogen