title: Pharmacokinetic study of dipyrone metabolite 4-MAA in the horse and possible implications for doping control.
abstract: The pharmacokinetic behaviour of dipyrone metabolite 4-MAA in serum was determined in seven horses of different breeds after a single intravenous dose administration. A biexponential formula was fitted to the serum concentration vs. time data. The median half-life of the elimination phase (t1/2 beta) was 4.85 h (range 5.04 h), the median volume of distribution (Vd(area)) was 1.85 L/kg (range 3.2 L/kg) and median of total clearance was 4.0 mL/min/kg (range 2.3 mL/min/kg).
authors.affiliation: Institut für Pharmakologie, Toxikologie und Pharmazie, Tierärztliche Hochschule Hannover, Germany.
authors.forename: A M
authors.initials: AM
authors.lastname: Klaus
authors.forename: Y
authors.initials: Y
authors.lastname: Schlingloff
authors.forename: U
authors.initials: U
authors.lastname: Kleinitz
authors.forename: M
authors.initials: M
authors.lastname: Böttcher
authors.forename: H J
authors.initials: HJ
authors.lastname: Hapke
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000378:metabolism; D019540:Area Under Curve; D004177:Dipyrone / Q000031:analogs & derivatives* / Q000097:blood / Q000378:metabolism / Q000493:pharmacokinetics; D004300:Doping in Sports; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D006207:Half-Life; D006736:Horses / Q000097:blood / Q000378:metabolism*; D008297:Male; D008657:Metabolic Clearance Rate; D047069:Pyrazolones
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D047069:Pyrazolones; D004177:Dipyrone; C008667:noramidopyrine