[The role of intracellular activation of enzymes in pathogenesis of acute pancreatitis--literature review].
Pathophysiology of acute pancreatitis (AP) is not full clear to present-day. Current review shows an importance of experimental models of AP with observations of intracellular changes during early stages of disease. One of the actual opinion suggest that abnormality in intracellular transport, secretion with intracellular activation of enzyme protein plays an important role in evolution of AP. These events further start cascade reactions and lead to autodigestion of pancreas.
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I Katedry i Kliniki Chirurgii Ogólnej, Slaskiej Akademii Medycznej w Katowicach.
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D000208:Acute Disease; D000818:Animals; D001692:Biological Transport / Q000502:physiology; D004789:Enzyme Activation / Q000502:physiology; D006801:Humans; D015388:Organelles / Q000648:ultrastructure; D010195:Pancreatitis / Q000201:enzymology* / Q000473:pathology