title: Increase in age at onset of rheumatoid arthritis in Japan over a 30 year period.
abstract: OBJECTIVE
  To determine changes in demographic variables and severity of rheumatoid arthritis (RA) that may have occurred during the 30 year period from 1960 to 1990 in Japan.
  
  
  METHODS
  Using records of patients diagnosed with RA from two hospitals, demographic and clinical features at initial visit were compared between two groups, one from 1960 to 1965 (group I) and the other from 1985 to 1990 (group II).
  
  
  RESULTS
  Mean age at the time of onset of the disease increased significantly from 37.5 years in group I to 46.9 in group II. The peak age at onset of RA shifted from the third to the fifth decade between group I and group II. There was no obvious change in morbidity as determined by seropositivity, rheumatoid nodules, and assessments of hip involvement.
  
  
  CONCLUSIONS
  The age at onset of RA was delayed during a recent 30 year period in Japan. This increase in age at onset might result from environmental changes that occurred in Japan or may reflect a birth cohort phenomenon. Improvement of severity of disease was not found in this study.
authors.affiliation: Department of Rheumatology, Shichikawa Arthritis, Research Centre, Mie, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Imanaka
authors.forename: K
authors.initials: K
authors.lastname: Shichikawa
authors.forename: K
authors.initials: K
authors.lastname: Inoue
authors.forename: Y
authors.initials: Y
authors.lastname: Shimaoka
authors.forename: Y
authors.initials: Y
authors.lastname: Takenaka
authors.forename: S
authors.initials: S
authors.lastname: Wakitani
mesh_terms: D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000453:epidemiology*; D002648:Child; D005260:Female; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D012424:Rural Population; D012737:Sex Factors; D014505:Urban Population