Overdose, suicide attempts and death among a cohort of naltrexone-treated opioid addicts.
In a study evaluating naltrexone with either an intensive psychosocial protocol or standard community treatment for opioid dependence, 13 of 81 subjects overdosed within a 12-month period of study participation. There were four fatalities, one of which was a suicide. Among the nine nonfatal overdoses, there were four suicide attempts. Characteristics of subjects and naltrexone-taking are described.
Miotto
K
K
Matrix Center, Los Angeles, CA, USA.
McCann
M J
MJ
Rawson
R A
RA
Frosch
D
D
Ling
W
W
D000328:Adult; D003866:Depressive Disorder / Q000523:psychology; D005260:Female; D006801:Humans; D008297:Male; D009271:Naltrexone / Q000009:adverse effects / Q000627:therapeutic use*; D009292:Narcotic Antagonists / Q000009:adverse effects / Q000627:therapeutic use*; D009294:Narcotics / Q000506:poisoning*; D009293:Opioid-Related Disorders / Q000188:drug therapy* / Q000401:mortality* / Q000523:psychology; D011569:Psychiatric Status Rating Scales; D011613:Psychotherapy; D013406:Suicide, Attempted / Q000523:psychology*
D009292:Narcotic Antagonists; D009294:Narcotics; D009271:Naltrexone