In vivo effect of pachymatismin, a new marine glycoprotein, on a human non-small-cell lung carcinoma.
Pachymatismin is a novel glycoprotein extracted from a marine sponge, which has an antiproliferative effect in vitro on cells from a human non-small-cell bronchopulmonary carcinoma (NSCLC-N6). The drug blocks irreversibly the cells in the G0/G1 phase of the cell cycle. Here, we investigate the antitumor activity of pachymatismin against this cell line. Tumor growth was studied after three weeks treatment of nude mice by different doses of pachymatismin. A significant decrease in tumor growth was observed.
Zidane
M
M
ISOMer, SMAB, Laboratoire de Pharmacologie Marine, Faculté de Pharmacie de Nantes, France.
Moré
M T
MT
Pondaven
P
P
Jaquot
C
C
Riou
D
D
Roussakis
C
C
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001685:Biological Factors / Q000494:pharmacology*; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006023:Glycoproteins / Q000494:pharmacology*; D006801:Humans; D007275:Injections, Intravenous; D036341:Intercellular Signaling Peptides and Proteins; D008175:Lung Neoplasms / Q000188:drug therapy*; D051379:Mice; D008819:Mice, Nude; D011161:Porifera / Q000737:chemistry*; D014183:Transplantation, Heterologous; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000637:transplantation
D000970:Antineoplastic Agents; D001685:Biological Factors; D006023:Glycoproteins; D036341:Intercellular Signaling Peptides and Proteins; C106743:pachymatismin protein, Pachymatisma johnstonii