title: Osteogenic protein-1 mRNA in the uterine endometrium.
abstract: OP-1, a bone morphogenetic protein (BMP) in the TGF-beta superfamily, is expressed at high levels in the kidney and in the endometrium of the uterus of non-pregnant mice. During pregnancy the OP-1 mRNA in the endometrium rapidly declined at 4 dpc. Thereafter, OP-1 transcripts were detected in the trophoblastic giant cells of the placenta and the fetal tissues. The uterine OP-1 mRNA downregulation could be mimicked by administration of 17 beta-estradiol but not by progesterone to non-pregnant animals. In contrast, OP-1 mRNA expression in kidneys and ovaries was not affected by pregnancy or estrogen treatment. The selective effect of estrogen on OP-1 mRNA in the uterus suggests that OP-1 expression is regulated by tissue specific mechanisms.
authors.affiliation: Creative BioMolecules, Hopkinton, Massachusetts 01748, USA.
authors.forename: E
authors.initials: E
authors.lastname: Ozkaynak
authors.forename: D F
authors.initials: DF
authors.lastname: Jin
authors.forename: M
authors.initials: M
authors.lastname: Jelic
authors.forename: S
authors.initials: S
authors.lastname: Vukicevic
authors.forename: H
authors.initials: H
authors.lastname: Oppermann
mesh_terms: D000818:Animals; D015152:Blotting, Northern; D055419:Bone Morphogenetic Protein 7; D019485:Bone Morphogenetic Proteins / Q000235:genetics* / Q000378:metabolism; D015536:Down-Regulation / Q000502:physiology; D004622:Embryo, Mammalian / Q000378:metabolism; D004717:Endometrium / Q000378:metabolism*; D004958:Estradiol / Q000494:pharmacology; D005260:Female; D005786:Gene Expression Regulation; D017403:In Situ Hybridization; D007668:Kidney / Q000378:metabolism; D051379:Mice; D010053:Ovary / Q000166:cytology / Q000378:metabolism; D010920:Placenta / Q000737:chemistry / Q000378:metabolism; D011247:Pregnancy; D011374:Progesterone / Q000494:pharmacology; D012333:RNA, Messenger / Q000378:metabolism*; D016212:Transforming Growth Factor beta
chemical_list: D055419:Bone Morphogenetic Protein 7; D019485:Bone Morphogenetic Proteins; D012333:RNA, Messenger; D016212:Transforming Growth Factor beta; D011374:Progesterone; D004958:Estradiol