The usefulness of technetium-99m-MIBI scintimammography in diagnosis of breast cancer: using surgical histopathologic diagnosis as the gold standard.
The purpose of this study was to evaluate the usefulness of 99mTc-MIBI scintinammography for the detection of breast cancer.


METHODS
Sixty-one consecutive patients referred for a suspicions breast lesion on clinical examination were studied with 99mTc-MIBI scintimammography. There were 60 female patients and 1 male patient with 63 pulpable breast abnormalities. Each patient received 20mCi 99mTc-MIBI intravenously. Ten and 120 minutes postinjection, three planar views, right and left lateral prone and anterior supine thoracic views, were obtained. The patient underwent surgery within one week and the final diagnostic results (histopathology) were obtained.


RESULTS
Thirty-two of 63 abnormalities of breast were pathologically confirmed breast cancer, and 31 were benign lesions. In the group of patients studied, the sensitivity of 99mTc-MIBI scintimammography was 78.1% (25 true-positive, 7 false-negative) and the specificity was 90.3% (28 true-negative, 3 false positive). The positive predictive value was 89.3%, the negative predictive value was 80.0%, the positive likelihood ratio was 8.1, the negative likelihood ratio was 0.2.


CONCLUSIONS
This study showed the high diagnostic accuracy of 99mTc-MIBI scintimammography in detecting breast cancer. 99mTc-MIBI scintimammography can be used as an assistant method to non-invasively assess breast cancer invasiveness before surgery.
Chen
S L
SL
Department of Nuclear Medicine, Zhongshan Hospital, Shanghai Medical University, China.
Yin
Y Q
YQ
Chen
J X
JX
Sun
X G
XG
Xiu
Y
Y
Liu
W G
WG
Liu
M
M
Zhu
W M
WM
Zhang
Y B
YB
D001941:Breast Diseases / Q000000981:diagnostic imaging / Q000473:pathology; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology*; D018567:Breast Neoplasms, Male / Q000000981:diagnostic imaging* / Q000473:pathology*; D002277:Carcinoma / Q000145:classification / Q000000981:diagnostic imaging* / Q000473:pathology*; D003937:Diagnosis, Differential; D005188:False Negative Reactions; D005189:False Positive Reactions; D005260:Female; D006801:Humans; D008297:Male; D011237:Predictive Value of Tests; D011336:Probability; D011859:Radiography; D011877:Radionuclide Imaging; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D017256:Technetium Tc 99m Sestamibi
D017256:Technetium Tc 99m Sestamibi