Bripiodionen, a new inhibitor of human cytomegalovirus protease from Streptomyces sp. WC76599.
Bripiodionen (1), a new natural product, was isolated from Streptomyces sp. WC76599 during the screening of microbial fermentation extracts for their ability to inhibit human cytomegalovirus protease. The structure of 1 was elucidated by spectroscopic methods. Compound 1 displayed inhibitory activity against human cytomegalovirus protease with an IC50 value of 30 microM.
Shu
Y Z
YZ
Bristol-Myers Squibb Pharmaceutical Research Institute, Wallingford, Connecticut 06492, USA.
Ye
Q
Q
Kolb
J M
JM
Huang
S
S
Veitch
J A
JA
Lowe
S E
SE
Manly
S P
SP
D000818:Animals; D003470:Culture Media; D003587:Cytomegalovirus / Q000187:drug effects / Q000201:enzymology*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D011480:Protease Inhibitors / Q000302:isolation & purification / Q000494:pharmacology*; D011714:Pyrans / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology*; D011760:Pyrrolidinones / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology*; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013056:Spectrophotometry, Ultraviolet; D013302:Streptomyces / Q000737:chemistry / Q000378:metabolism*; D014407:Tumor Cells, Cultured
D003470:Culture Media; D011480:Protease Inhibitors; D011714:Pyrans; D011760:Pyrrolidinones; C106398:bripiodionen