title: Peptides in membranes: tipping the balance of membrane stability.
abstract: This review describes a class of peptides that associate with lipids in membranes and are commonly known as 'oblique-orientated peptides'. Owing to an asymmetric distribution of hydrophobic residues along the axis of the alpha-helix, such peptides can destabilize membranes or lipid cores, thereby facilitating such cellular processes as vesicular fusion or protein transport across subcellular compartments, as well as remodelling of lipid cores.
authors.affiliation: Centre Biophysique Moleculaire Numerique, Fac. Agronomiques, Gembloux, Belgium.
authors.forename: R
authors.initials: R
authors.lastname: Brasseur
authors.forename: T
authors.initials: T
authors.lastname: Pillot
authors.forename: L
authors.initials: L
authors.lastname: Lins
authors.forename: J
authors.initials: J
authors.lastname: Vandekerckhove
authors.forename: M
authors.initials: M
authors.lastname: Rosseneu
mesh_terms: D000544:Alzheimer Disease / Q000209:etiology; D001692:Biological Transport; D002462:Cell Membrane / Q000502:physiology*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D050356:Lipid Metabolism; D008561:Membrane Fusion; D008563:Membrane Lipids / Q000378:metabolism; D008565:Membrane Proteins / Q000737:chemistry* / Q000502:physiology; D021382:Protein Sorting Signals / Q000737:chemistry; D014764:Viral Proteins / Q000737:chemistry
chemical_list: D008563:Membrane Lipids; D008565:Membrane Proteins; D021382:Protein Sorting Signals; D014764:Viral Proteins