title: A model of Plasmodium falciparum lactate dehydrogenase and its implications for the design of improved antimalarials and the enhanced detection of parasitaemia.
authors.affiliation: Molecular Recognition Centre, University of Bristol School of Medical Sciences, UK.
authors.forename: R B
authors.initials: RB
authors.lastname: Sessions
authors.forename: V
authors.initials: V
authors.lastname: Dewar
authors.forename: A R
authors.initials: AR
authors.lastname: Clarke
authors.forename: J J
authors.initials: JJ
authors.lastname: Holbrook
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000962:Antimalarials / Q000138:chemical synthesis* / Q000378:metabolism; D001665:Binding Sites; D018360:Crystallography, X-Ray; D015195:Drug Design; D001411:Geobacillus stearothermophilus / Q000201:enzymology; D006072:Gossypol / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000378:metabolism; D006801:Humans; D007700:Kinetics; D007770:L-Lactate Dehydrogenase / Q000737:chemistry* / Q000378:metabolism; D019344:Lactic Acid / Q000378:metabolism; D008956:Models, Chemical; D008958:Models, Molecular; D008969:Molecular Sequence Data; D009243:NAD / Q000031:analogs & derivatives / Q000378:metabolism; D010963:Plasmodium falciparum / Q000201:enzymology*; D017434:Protein Structure, Tertiary; D016415:Sequence Alignment; D017384:Sequence Deletion; D013237:Stereoisomerism; D013552:Swine
chemical_list: D000962:Antimalarials; D009243:NAD; C073920:gossylic lactone; D019344:Lactic Acid; C005941:3-acetylpyridine adenine dinucleotide; C073921:gossylic nitrile-1,1'-diacetate; D007770:L-Lactate Dehydrogenase; D006072:Gossypol