title: Large increase in cardiac output in a patient with ARDS and acute right heart failure during inhalation of nitric oxide.
abstract: BACKGROUND
  Inhaled nitric oxide (NO), a selective pulmonary vasodilator, reduces pulmonary artery pressure in patients with acute respiratory distress syndrome (ARDS). In spite of the reduction of right ventricular afterload, the effect of NO on cardiac output remains unclear.
  
  
  METHODS
  A patient with ARDS and echocardiographically determined severe acute right heart failure was treated with increasing concentrations of inhaled nitric oxide (NO). Haemodynamic and gas exchange variables were determined for each concentration of NO. NO treatment was continued for 3 days.
  
  
  RESULTS
  During initial right heart failure, administration of NO resulted in a large increase (32%) in cardiac output in a dose-dependent manner. When right ventricular function had improved, inhalation of NO did not increase cardiac output.
  
  
  CONCLUSIONS
  Our observations suggest that inhalation of NO is likely to increase cardiac output in ARDS when severe acute right heart failure is present.
authors.affiliation: Department of Anaesthesiology, University of Freiburg, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Benzing
authors.forename: G
authors.initials: G
authors.lastname: Mols
authors.forename: U
authors.initials: U
authors.lastname: Beyer
authors.forename: K
authors.initials: K
authors.lastname: Geiger
mesh_terms: D000208:Acute Disease; D000280:Administration, Inhalation; D002302:Cardiac Output / Q000187:drug effects*; D004452:Echocardiography; D004562:Electrocardiography; D006333:Heart Failure / Q000188:drug therapy / Q000503:physiopathology*; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000008:administration & dosage / Q000494:pharmacology*; D011659:Pulmonary Gas Exchange / Q000187:drug effects / Q000502:physiology; D012128:Respiratory Distress Syndrome / Q000188:drug therapy / Q000503:physiopathology*; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000494:pharmacology*; D018497:Ventricular Dysfunction, Right / Q000188:drug therapy / Q000503:physiopathology*
chemical_list: D014665:Vasodilator Agents; D009569:Nitric Oxide