Comparative quantitation of cerebral blood volume: SPECT versus PET.
Quantification of cerebral blood volume (CBV) measured by SPECT has been used for evaluation of cerebral hemodynamics in patients with cerebrovascular diseases. The accuracy of such quantification, however, has not been validated with PET.


METHODS
CBV was assessed using SPECT and in vitro 99mTc-labeled red blood cells and PET with the 15O steady-state inhalation method and C15O. In 23 patients with carotid artery disease, we measured hemispheric (including cortical and subcortical areas) CBV, and in 11 patients, we measured regional CBV in small cortical regions. We further evaluated the interhemispheric and inter-regional asymmetry of CBV with both methods.


RESULTS
Quantitative values of both hemispheric and regional CBV measured by SPECT were significantly correlated with those measured by PET in the same patients. There was a significant correlation between the side-to-side asymmetry of CBV for both methods.


CONCLUSIONS
This study demonstrates usefulness and the accuracy of SPECT for quantitative CBV assessment in comparison with the less widely available PET procedures.
Vlasenko
A
A
CYCERON, Biomedical Cyclotron Centre CEA/DRM, Centre F. Baclesse, Caen, France.
Petit-Taboué
M C
MC
Bouvard
G
G
Morello
R
R
Derlon
J M
JM
D002248:Carbon Monoxide; D002340:Carotid Artery Diseases / Q000000981:diagnostic imaging* / Q000503:physiopathology; D002343:Carotid Artery, Internal; D002560:Cerebrovascular Circulation / Q000502:physiology*; D004912:Erythrocytes; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008875:Middle Aged; D010104:Oxygen Radioisotopes; D013667:Technetium; D014055:Tomography, Emission-Computed; D015899:Tomography, Emission-Computed, Single-Photon
D010104:Oxygen Radioisotopes; D013667:Technetium; D002248:Carbon Monoxide