Allelic loss on chromosome 11 is uncommon in parathyroid glands of patients with hypercalcaemic secondary hyperparathyroidism.
OBJECTIVE
To test the hypothesis that progression of secondary hyperparathyroidism from normocalcaemia to hypercalcaemia occurs because of development of monoclonal parathyroid tumours after the inactivation of a tumour suppressor gene on chromosome 11q13.


METHODS
Experimental study.


METHODS
University hospital, Sweden.


METHODS
13 Patients with secondary hypercalcaemic hyperparathyroidism.


METHODS
48 Parathyroid glands were removed, 39 of which were analysed using Southern blot hybridisation and polymerase chain reaction.


METHODS
Loss of heterozygosity on several loci on chromosome 11, including 11q13, which carries the presumed gene for multiple endocrine neoplasia type 1 (MEN1).


RESULTS
Monosomy for chromosome 11 was found in one tumour.


CONCLUSIONS
It seems unlikely that the MEN1 gene is of importance in the progression of secondary hyperparathyroidism.
Farnebo
F
F
Department of Molecular Medicine, Karolinska Hospital, Stockholm, Sweden.
Farnebo
L O
LO
Nordenström
J
J
Larsson
C
C
D000293:Adolescent; D000328:Adult; D000368:Aged; D000483:Alleles; D002648:Child; D002872:Chromosome Deletion; D002880:Chromosomes, Human, Pair 11 / Q000235:genetics*; D018450:Disease Progression; D005260:Female; D006579:Heterozygote; D006801:Humans; D006934:Hypercalcemia / Q000209:etiology / Q000235:genetics; D006962:Hyperparathyroidism, Secondary / Q000150:complications / Q000235:genetics*; D006965:Hyperplasia; D008297:Male; D008875:Middle Aged; D010280:Parathyroid Glands / Q000473:pathology / Q000503:physiopathology*