title: [Pharmacology of potassium-sparing diuretics].
abstract: Potassium sparing diuretics in combination with thiazides represent a therapeutical enrichment if applied correctly that is with respect to contraindications, interactions (especially with ACE-inhibitors and AT1-antagonists) and to pharmacokinetic properties. Triamterene has to be administered twice a day while amiloride and spironolactone are effective for 24 hours. Of course, pharmacokinetic parameters of potassium sparing diuretics have to be considered also in fixed combinations.
authors.affiliation: Institut für Pharmakologie, Medizinische Universität Lübeck.
authors.forename: P
authors.initials: P
authors.lastname: Dominiak
mesh_terms: D000584:Amiloride / Q000494:pharmacology; D004232:Diuretics / Q000494:pharmacology*; D006801:Humans; D000451:Mineralocorticoid Receptor Antagonists / Q000494:pharmacology; D011188:Potassium; D013148:Spironolactone / Q000494:pharmacology; D014223:Triamterene / Q000494:pharmacology
chemical_list: D004232:Diuretics; D000451:Mineralocorticoid Receptor Antagonists; D013148:Spironolactone; D000584:Amiloride; D011188:Potassium; D014223:Triamterene