Prediction of blood cyclosporine concentrations in haematological patients with multidrug resistance by means of total, lean and different adipose factors dosing body weight using Bayesian and non-linear least squares methods.
In the present work, we have studied the prediction of blood cyclosporine (CsA) concentrations in haematological patients with multidrug resistance by means of total body weight, 25, 50 and 75 adipose factor dosing body weight, and lean body weight using the Bayesian method (BM) and non-linear least squares method (NLLSM) during the second course of CsA treatment. The results showed that both BM and NLLSM can minimize the prediction difference among different dosing body weight parameter types. The results also slightly favour the predictions with lean body weight.
Wu
G
G
Institute of Clinical Pharmacology and Toxicology, Medical School, University of Udine, Italy.
Furlanut
M
M
D000328:Adult; D001499:Bayes Theorem; D015982:Bias; D001835:Body Weight; D016572:Cyclosporine / Q000097:blood* / Q000493:pharmacokinetics; D018432:Drug Resistance, Multiple; D005260:Female; D006402:Hematologic Diseases / Q000097:blood; D006801:Humans; D007166:Immunosuppressive Agents / Q000097:blood* / Q000493:pharmacokinetics; D016018:Least-Squares Analysis; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D012737:Sex Factors; D012984:Software
D007166:Immunosuppressive Agents; D016572:Cyclosporine