title: Mycophenolate mofetil and prednisone as maintenance treatment after kidney transplantation.
abstract: BACKGROUND
  Hemolytic uremic syndrome (HUS) is an infrequent but severe complication of kidney transplantation. Cyclosporine-induced microangiopathy may be the causative factor in allograft recipients with HUS. In transplant recipients with HUS, discontinuation of cyclosporine is generally advised. This often leads to loss of the graft.
  
  
  METHODS
  An adult kidney transplant recipient developed HUS in the third week after transplantation. Maintenance immunosuppression was changed to mycophenolate mofetil and prednisone after cyclosporine was discontinued.
  
  
  RESULTS
  The change in immunosuppressive therapy led to remission of the HUS and stable graft function.
  
  
  CONCLUSIONS
  In transplant recipients receiving cyclosporine who suffer from HUS, the possibility of conversion from cyclosporine to mycophenolate mofetil should be considered. As this case shows, complete remission of HUS and maintenance of the graft are possible.
authors.affiliation: Department of Internal Medicine I, University Hospital Rotterdam, The Netherlands.
authors.forename: T
authors.initials: T
authors.lastname: van Gelder
authors.forename: R J
authors.initials: RJ
authors.lastname: Klaassen
authors.forename: I
authors.initials: I
authors.lastname: van Riemsdijk-van Overbeeke
authors.forename: J N
authors.initials: JN
authors.lastname: IJzermans
authors.forename: W
authors.initials: W
authors.lastname: Weimar
mesh_terms: D005260:Female; D006084:Graft Rejection / Q000517:prevention & control; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D016030:Kidney Transplantation / Q000276:immunology*; D008875:Middle Aged; D009173:Mycophenolic Acid / Q000031:analogs & derivatives; D011241:Prednisone / Q000627:therapeutic use*
chemical_list: D007166:Immunosuppressive Agents; D009173:Mycophenolic Acid; D011241:Prednisone