Myelodysplastic syndrome presenting with clonal rearrangement isolated to chromosomal region 1q.
Myelodysplastic syndrome (MDS) is a malignant hematologic disorder that may present with clinical features consistent with the diagnosis of severe aplastic anemia (SAA). Distinguishing the two disorders may depend on the presence of a clonal chromosomal abnormality. In the following, we report a case of MDS associated with what we believe to be a previously unreported clonal abnormality of chromosome 1q, a finding that enabled us to distinguish between MDS and SAA.
Mogul
M J
MJ
Division of Pediatric Hematology, Oncology, and Bone Marrow Transplant, Emory University School of Medicine, Atlanta, Georgia, 30322, USA.
Brady
K
K
Brothman
A R
AR
Adams
R
R
Peterson
F B
FB
Beatty
P G
PG
D000328:Adult; D002869:Chromosome Aberrations; D002878:Chromosomes, Human, Pair 1; D005260:Female; D006801:Humans; D009190:Myelodysplastic Syndromes / Q000235:genetics*