title: Merosin positive congenital muscular dystrophy with mental deficiency, epilepsy and MRI changes in the cerebral white matter.
abstract: A girl born from consanguineous Turkish parents had marked hypotonia from birth and delayed milestones. She was able to stand unaided by 3 years of age with then progressive worsening of motor abilities. She had a severe non-progressive mental deficiency. Epilepsy occurred by 6 years of age. Ophthalmological investigation was normal. A marked white matter high signal was seen on magnetic resonance imaging without cortical dysplasia. Dystrophic changes were seen on muscle biopsy. Two brothers had had a similar history with early death. Muscular immunocytochemical studies showed a normal staining for dystrophin and all dystrophin related glycoproteins (including 43 and 50 DAG). Merosin staining was normal. This case differs from Fukuyama's congenital dystrophy, from merosin negative congenital muscular dystrophy, or from other congenital muscular dystrophy with CNS dysfunction. It underlines the heterogeneity of congenital muscular dystrophy and the non-specific aspect of white matter changes on neuro-imaging.
authors.affiliation: Service de Neuropédiatrie, Hôpital St. Eloi, Montpellier, France.
authors.forename: B
authors.initials: B
authors.lastname: Echenne
authors.forename: F
authors.initials: F
authors.lastname: Rivier
authors.forename: A J
authors.initials: AJ
authors.lastname: Jellali
authors.forename: M
authors.initials: M
authors.lastname: Azais
authors.forename: D
authors.initials: D
authors.lastname: Mornet
authors.forename: F
authors.initials: F
authors.lastname: Pons
mesh_terms: D000328:Adult; D001706:Biopsy; D002540:Cerebral Cortex / Q000473:pathology; D003598:Cytoskeletal Proteins / Q000032:analysis; D049030:Dystroglycans; D016189:Dystrophin / Q000032:analysis; D004827:Epilepsy / Q000150:complications / Q000175:diagnosis* / Q000378:metabolism; D005260:Female; D006801:Humans; D008607:Intellectual Disability / Q000150:complications / Q000175:diagnosis* / Q000378:metabolism; D007797:Laminin / Q000032:analysis*; D008279:Magnetic Resonance Imaging; D008562:Membrane Glycoproteins / Q000032:analysis; D018482:Muscle, Skeletal / Q000737:chemistry / Q000473:pathology; D009136:Muscular Dystrophies / Q000150:complications / Q000175:diagnosis* / Q000378:metabolism; D009412:Nerve Fibers / Q000473:pathology; D049031:Sarcoglycans
chemical_list: D003598:Cytoskeletal Proteins; C483081:DAG1 protein, human; D016189:Dystrophin; D007797:Laminin; D008562:Membrane Glycoproteins; D049031:Sarcoglycans; D049030:Dystroglycans