title: Clinical significance of neurocysticercosis in endemic villages. The Cysticercosis Working Group in Peru.
abstract: Cerebral cysticercosis is the main cause of late-onset epilepsy in most developing countries. Data on the neuroepidemiology of cysticercosis in endemic populations is scarce. In an endemic village on the northern coast of Peru, 49 individuals with neurological symptomatology (41 epileptic and 8 non-epileptic) were screened for antibodies to Taenia solium, using a serum electroimmunotransfer blot assay. Fifteen subjects were seropositive, 14 (34%) of those with epilepsy but only one (13%) of those who were non-epileptic. A history of passing proglottides was associated with positive serology. Thirteen of the 15 seropositive individuals underwent cerebral computed tomography; only 7 (54%) were abnormal. A randomly selected sample of 20 pigs from the village was also tested, and 6 (30%) were seropositive. This study demonstrated the importance of cysticercosis in the aetiology of epilepsy in endemic villages and the close relationship between porcine and human infection.
authors.affiliation: Universidad Peruana Cayetano Heredia, Lima, Peru. hhgarcia@prisma.org.pe
authors.forename: H H
authors.initials: HH
authors.lastname: García
authors.forename: R H
authors.initials: RH
authors.lastname: Gilman
authors.forename: V C
authors.initials: VC
authors.lastname: Tsang
authors.forename: A E
authors.initials: AE
authors.lastname: Gonzalez
mesh_terms: D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D000909:Antibodies, Helminth / Q000302:isolation & purification; D001927:Brain Diseases / Q000150:complications* / Q000000981:diagnostic imaging / Q000469:parasitology; D002648:Child; D003551:Cysticercosis / Q000150:complications* / Q000000981:diagnostic imaging / Q000469:parasitology; D004827:Epilepsy / Q000000981:diagnostic imaging / Q000469:parasitology* / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010568:Peru / Q000453:epidemiology; D013552:Swine / Q000469:parasitology; D014057:Tomography, X-Ray Computed
chemical_list: D000909:Antibodies, Helminth