title: [Dental and oral aspects in pediatric liver transplant patients. A comparison between the effects of cyclosporine A and FK 506].
abstract: The evolution and the improvement of the surgical techniques and pharmacological therapies brought to new patients categories, also in odontoiatric field for example patients who underwent organ transplantation. Among the patients, we wanted to dwell our attention on pediatric patients after liver transplantation, by light of the new therapeutic outlines modifications. In fact in these young patients it is possible to observe, besides the severe systemic consequences, also the involvement of the oral cavity. After the transplantation, the immunosuppressive therapy is set up and it is based on the use of cyclosporine with the possible azotiopine or steroid association. The cyclosporine side-effects are well known and, among these, the gingival hyperplasia. FK506 is a drug recently introduced, it is a strong immunosuppressor. Therefore we began to estimate patients who assumed FK 506, in order to compare the effect at the gingival level among patients who follow a cyclosporine therapy.
authors.affiliation: Clinica Odontoiatrica, Università degli Studi di Brescia.
authors.forename: E
authors.initials: E
authors.lastname: Savoldi
authors.forename: A
authors.initials: A
authors.lastname: Rolfi
authors.forename: A
authors.initials: A
authors.lastname: Majorana
authors.forename: D
authors.initials: D
authors.lastname: Alberti
mesh_terms: D002648:Child; D002675:Child, Preschool; D016572:Cyclosporine / Q000009:adverse effects*; D004359:Drug Therapy, Combination; D005260:Female; D005881:Gingiva / Q000187:drug effects*; D005885:Gingival Hyperplasia / Q000139:chemically induced; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D016031:Liver Transplantation; D008297:Male; D016559:Tacrolimus / Q000009:adverse effects*
chemical_list: D007166:Immunosuppressive Agents; D016572:Cyclosporine; D016559:Tacrolimus