History of vitamin D treatment of renal osteodystrophy.
Vitamin D treatment was tried when renal osteodystrophy was first recognized in the early 20th century, using vitamin D2, D3, or dihydrotachysterol. Large doses of vitamin D2 or D3 (150,000-500,000 IU) were prescribed by monitoring serum calcium, phosphate, and alkaline phosphatase. After the discovery of 1,25-dihydroxycholecalciferol, this compound or 1 alpha-hydroxycholecalciferol was applied to the treatment of renal osteodystrophy. In a preclinical study, especially of 1 alpha-hydroxycholecalciferol, nephritogenoside nephritis was the most responsive condition. These active vitamin D preparations are now widely used in patients with chronic renal failure under hemodialysis. Other active vitamin D compounds, such as hexafluoro-1,25-dihydroxycholecalciferol and 22-oxacalcitriol, are also under investigation.
Morii
H
H
Second Department of Internal Medicine, Osaka City University Medical School, Japan.
Ishimura
E
E
Inoue
T
T
Tabata
T
T
Morita
A
A
Nishii
Y
Y
Fukushima
M
M
D000818:Animals; D012080:Chronic Kidney Disease-Mineral and Bone Disorder / Q000188:drug therapy / Q000266:history*; D049673:History, 20th Century; D006801:Humans; D014807:Vitamin D / Q000266:history* / Q000627:therapeutic use
D014807:Vitamin D