title: Identification of a novel HLA-B allele (B*4202) in a Saudi Arabian family with Behçet's disease.
abstract: A new HLA-B antigen, tentatively called HLA-B42AND, was identified as a B42 serologic variant in a Saudi Arabian family. DNA sequencing analysis of the second and third exon of this new B allele revealed that B42AND was identical to B*4201 except for a single T to C substitution at position 97 of exon 2. This substitution results in histidine (CAC) at codon 9 in B42AND instead of tyrosine (TAC) in B*4201. The antigen frequency of B42AND in a Saudi Arabian population was around 10%. This novel B42AND has officially been named HLA-B*4202.
authors.affiliation: Japanese Red Cross, Kanagawa.
authors.forename: H
authors.initials: H
authors.lastname: Ando
authors.forename: N
authors.initials: N
authors.lastname: Mizuki
authors.forename: S
authors.initials: S
authors.lastname: Ohno
authors.forename: K F
authors.initials: KF
authors.lastname: Tabbara
authors.forename: S
authors.initials: S
authors.lastname: Taguchi
authors.forename: M
authors.initials: M
authors.lastname: Yamazaki
authors.forename: N
authors.initials: N
authors.lastname: Mizuki
authors.forename: Y
authors.initials: Y
authors.lastname: Miyata
authors.forename: K
authors.initials: K
authors.lastname: Wakisaka
authors.forename: H
authors.initials: H
authors.lastname: Inoko
mesh_terms: D000483:Alleles; D001483:Base Sequence; D001528:Behcet Syndrome / Q000453:epidemiology / Q000235:genetics*; D005787:Gene Frequency; D015235:HLA-B Antigens / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D012529:Saudi Arabia / Q000453:epidemiology
chemical_list: D015235:HLA-B Antigens