[Role of the conformation changement of CD4 in the HIV-cell fusion].
It is well known that the gp120-gp41 complex undergoes a conformational change after CD4 binding. It is likely that CD4 undergoes a conformational change as well. Recently, a calculation of the normal modes of the two N-terminal domains of CD4 has shown that a hinge-bending motion of one of these domains with respect to the other may occur. In the present study, results obtained previously are verified with two other normal mode calculations, starting from crystallographic structures of different origin. A scheme describing the first steps of the process leading to cell infection by human immunodeficiency virus (HIV) is then proposed. It rests upon the idea that CD4 and gp120-gp41 conformational changes allow for bringing the cell and virus membranes closer to each other.
Sanejouand
Y H
YH
Laboratoire de physique quantique, UMR 5626 du CNRS, IRSAMC, Université Paul-Sabatier, Toulouse, France.
D015704:CD4 Antigens / Q000737:chemistry*; D002459:Cell Fusion / Q000276:immunology*; D006678:HIV / Q000502:physiology*; D015699:HIV Envelope Protein gp120 / Q000737:chemistry; D015658:HIV Infections / Q000503:physiopathology; D066298:In Vitro Techniques; D008961:Models, Structural; D016281:Oncogene Protein gp140(v-fms) / Q000737:chemistry; D011487:Protein Conformation; D017434:Protein Structure, Tertiary
D015704:CD4 Antigens; D015699:HIV Envelope Protein gp120; D016281:Oncogene Protein gp140(v-fms)