[Prophylactic use of prostatilen in rats prior to exposure to +Gz loads as a way of reducing changes in urogenital organs].
Experimental verification of prostatilen prophylactics of changes in the urogenital organs consequent to g-loads was the idea of the work. The experiment was performed with 37 mongrel white male rats weighing 200-250 g who were exposed to the head-pelvis g-loads (+Gl) at 10 units. Behavior reactions of the rats were assessed with the "open field" technique immediately after centrifugation; weighing coefficients of the urogenital organs (the organ/body mass relation) were determined, and histological and morphometric analyses of prostate, testis and kidney were made. A significant moderating effect of prophylactic prostatilen on the stress-reactions in animals was first revealed; prostatilen was also found to speed up adaptation. This was concluded from normalization of the hemodynamics, a decrease in venous plethora and epithelial dystrophy, absence of basophilia in conjunctive tissue of the urogenital organs. Distention and overfilling of acini by secret and the number of epithelial acinus hulled into the lumen were markedly less in prostate. Spermatogenesis in testis was normalized, too. The histological profile of kidney approached the norm. Results of the experiment showed that prostatilen is a promising preparation from the standpoint of moderation of stress-reactions and counteraction of disorders in the urogenital organs caused by g-loads.
Novikov
V S
VS
Al'-Shukri
S Kh
SKh
Gorbachev
A G
AG
Tiurin
A G
AG
Amdiĭ
R E
RE
Iastrebov
D V
DV
D000818:Animals; D005303:Fertility Agents, Male / Q000494:pharmacology*; D006112:Gravitation; D007668:Kidney / Q000033:anatomy & histology / Q000187:drug effects; D008297:Male; D052801:Male Urogenital Diseases / Q000517:prevention & control; D010455:Peptides / Q000494:pharmacology*; D011467:Prostate / Q000033:anatomy & histology / Q000187:drug effects; D051381:Rats; D013091:Spermatogenesis / Q000187:drug effects; D013315:Stress, Psychological; D013737:Testis / Q000033:anatomy & histology / Q000187:drug effects; D014566:Urogenital System / Q000187:drug effects*
D005303:Fertility Agents, Male; D010455:Peptides; C069549:prostatilen