Concentrations of heroin, 06-monoacetylmorphine, and morphine in a lethal case following an oral heroin overdose.
A case of lethal overdose by heroin ingestion is presented. The concentrations of drugs were measured several hours after death. Heroin, 06-monoacetylmorphine, and morphine were identified and quantitated in blood, urine, and gastrointestinal contents by gas chromatography-mass spectrometry and high-performance liquid chromatography. Concentrations of heroin, 06-monoacetylmorphine, and morphine were 109, 168, and 1140 ng/mL, respectively, in blood and 17, 12, and 425 ng/g, respectively, in gastrointestinal content. In urine, however, only morphine was detected at 3650 ng/mL.
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Laboratoire de Police Scientifique, Marseille, France.
Fornaris
M
M
Salmon
T
T
Burle
J
J
Bresson
M
M
D000284:Administration, Oral; D000328:Adult; D002138:Calibration; D002851:Chromatography, High Pressure Liquid; D062787:Drug Overdose; D017809:Fatal Outcome; D008401:Gas Chromatography-Mass Spectrometry; D005766:Gastrointestinal Contents / Q000737:chemistry; D003932:Heroin / Q000032:analysis / Q000097:blood / Q000506:poisoning*; D006801:Humans; D008297:Male; D009020:Morphine / Q000032:analysis* / Q000097:blood / Q000652:urine; D009022:Morphine Derivatives / Q000032:analysis* / Q000097:blood; D009294:Narcotics / Q000009:adverse effects / Q000097:blood / Q000506:poisoning*; D012015:Reference Standards; D019966:Substance-Related Disorders
D009022:Morphine Derivatives; D009294:Narcotics; D003932:Heroin; D009020:Morphine; C026979:6-O-monoacetylmorphine