Expression of ER-D5 and EGFr in laryngeal carcinoma and pre-malignant epithelium.
The expression of estrogen receptors was biochemically assessed in a series of 46 cases of consecutive laryngeal carcinomas. ER-D5 and EGFr were also immunohistochemically detected in 44 and 46 cases respectively. There was no correlation between the expression of these molecules and the typical anatomo-clinical prognostic parameters of laryngeal tumors. The concomitant expression of estrogen receptors, ER-D5 and EGFr was also investigated in normal, hyperplastic and dysplastic epithelium. An increasing expression of ER-D5 and EGFr from normal to hyperplastic and dysplastic epithelium was noted. These data suggest a possible role of hormone receptors in the laryngeal carcinogenesis.
Maiorano
E
E
Institute of Pathological Anatomy, University of Bari, Italy. anatopat@cimedoc.uniba.it
Botticella
M A
MA
Marzullo
A
A
Resta
L
L
D014408:Biomarkers, Tumor / Q000032:analysis*; D002294:Carcinoma, Squamous Cell / Q000737:chemistry* / Q000473:pathology; D004848:Epithelium / Q000737:chemistry / Q000473:pathology; D066246:ErbB Receptors / Q000032:analysis*; D006801:Humans; D007822:Laryngeal Neoplasms / Q000737:chemistry* / Q000473:pathology; D007830:Larynx / Q000737:chemistry* / Q000473:pathology; D008875:Middle Aged; D011230:Precancerous Conditions / Q000737:chemistry* / Q000473:pathology; D011506:Proteins / Q000032:analysis*; D011960:Receptors, Estrogen / Q000032:analysis*
D014408:Biomarkers, Tumor; C059917:ERD5 protein, human; D011506:Proteins; D011960:Receptors, Estrogen; D066246:ErbB Receptors