title: CNF combination as adjuvant treatment in breast cancer patients is well tolerated.
abstract: In this study 194 women with breast cancer received adjuvant CNF combination therapy (cyclophosphamide, mitoxantrone and 5-fluorouracil). The side effects and acute toxicity of the regimen were recorded. Although myelosuppression is the dose-limiting factor of the CNF regimen, it was well tolerated and side effects were limited. This regimen induced no cardiotoxicity or irreversible alopecia. It is concluded that CNF is suitable as adjuvant chemotherapy for breast cancer patients.
authors.affiliation: Department of Oncology, Kuopio University Hospital, Finland.
authors.forename: P P
authors.initials: PP
authors.lastname: Hirvikoski
authors.forename: E J
authors.initials: EJ
authors.lastname: Kumpulainen
authors.forename: R T
authors.initials: RT
authors.lastname: Johansson
mesh_terms: D000328:Adult; D000368:Aged; D000469:Alkaline Phosphatase / Q000097:blood; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy*; D017024:Chemotherapy, Adjuvant; D003404:Creatinine / Q000097:blood; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000009:adverse effects; D004334:Drug Administration Schedule; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D008875:Middle Aged; D008942:Mitoxantrone / Q000008:administration & dosage / Q000009:adverse effects
chemical_list: D003520:Cyclophosphamide; D003404:Creatinine; D008942:Mitoxantrone; D000469:Alkaline Phosphatase; D005472:Fluorouracil