Identification of a novel HLA-B allele (B*4202) in a Saudi Arabian family with Behçet's disease.
A new HLA-B antigen, tentatively called HLA-B42AND, was identified as a B42 serologic variant in a Saudi Arabian family. DNA sequencing analysis of the second and third exon of this new B allele revealed that B42AND was identical to B*4201 except for a single T to C substitution at position 97 of exon 2. This substitution results in histidine (CAC) at codon 9 in B42AND instead of tyrosine (TAC) in B*4201. The antigen frequency of B42AND in a Saudi Arabian population was around 10%. This novel B42AND has officially been named HLA-B*4202.
Ando
H
H
Japanese Red Cross, Kanagawa.
Mizuki
N
N
Ohno
S
S
Tabbara
K F
KF
Taguchi
S
S
Yamazaki
M
M
Mizuki
N
N
Miyata
Y
Y
Wakisaka
K
K
Inoko
H
H
D000483:Alleles; D001483:Base Sequence; D001528:Behcet Syndrome / Q000453:epidemiology / Q000235:genetics*; D005787:Gene Frequency; D015235:HLA-B Antigens / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D012529:Saudi Arabia / Q000453:epidemiology
D015235:HLA-B Antigens