title: Allelic loss on chromosome 11 is uncommon in parathyroid glands of patients with hypercalcaemic secondary hyperparathyroidism.
abstract: OBJECTIVE
  To test the hypothesis that progression of secondary hyperparathyroidism from normocalcaemia to hypercalcaemia occurs because of development of monoclonal parathyroid tumours after the inactivation of a tumour suppressor gene on chromosome 11q13.
  
  
  METHODS
  Experimental study.
  
  
  METHODS
  University hospital, Sweden.
  
  
  METHODS
  13 Patients with secondary hypercalcaemic hyperparathyroidism.
  
  
  METHODS
  48 Parathyroid glands were removed, 39 of which were analysed using Southern blot hybridisation and polymerase chain reaction.
  
  
  METHODS
  Loss of heterozygosity on several loci on chromosome 11, including 11q13, which carries the presumed gene for multiple endocrine neoplasia type 1 (MEN1).
  
  
  RESULTS
  Monosomy for chromosome 11 was found in one tumour.
  
  
  CONCLUSIONS
  It seems unlikely that the MEN1 gene is of importance in the progression of secondary hyperparathyroidism.
authors.affiliation: Department of Molecular Medicine, Karolinska Hospital, Stockholm, Sweden.
authors.forename: F
authors.initials: F
authors.lastname: Farnebo
authors.forename: L O
authors.initials: LO
authors.lastname: Farnebo
authors.forename: J
authors.initials: J
authors.lastname: Nordenström
authors.forename: C
authors.initials: C
authors.lastname: Larsson
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000483:Alleles; D002648:Child; D002872:Chromosome Deletion; D002880:Chromosomes, Human, Pair 11 / Q000235:genetics*; D018450:Disease Progression; D005260:Female; D006579:Heterozygote; D006801:Humans; D006934:Hypercalcemia / Q000209:etiology / Q000235:genetics; D006962:Hyperparathyroidism, Secondary / Q000150:complications / Q000235:genetics*; D006965:Hyperplasia; D008297:Male; D008875:Middle Aged; D010280:Parathyroid Glands / Q000473:pathology / Q000503:physiopathology*