title: Factor V Leiden is associated with repeated and recurrent unexplained fetal losses.
abstract: Activated protein C resistance (APCR) is responsible for most cases of familial thrombosis. The factor V missense mutation Arg506 > Gln (FV Leiden) has been recognized as the commonest cause of this condition. Recently, it has been suggested that APCR is associated with second trimester fetal loss. We investigated the distribution of FV Leiden in a sample (n = 43) of Caucasian women with a history of two or more unexplained fetal losses. A group (n = 118) of parous women with uneventful pregnancies from the same ethnical background served as control. We found the mutation in 7 cases (16.28%) and 5 controls (4.24%; p = 0.011). A statistically significant difference between women with only early fetal loss vs those with late events (p = 0.04) was observed. Our data demonstrate a strong association between FV Leiden and fetal loss. Furthermore, they indicate that late events are more common in these patients.
authors.affiliation: Arteriosclerosis and Thrombosis Unit, I.R.C.C.S. Casa Sollievo della Sofferenza, S. Giovanni R. (FG), Italy.
authors.forename: E
authors.initials: E
authors.lastname: Grandone
authors.forename: M
authors.initials: M
authors.lastname: Margaglione
authors.forename: D
authors.initials: D
authors.lastname: Colaizzo
authors.forename: M
authors.initials: M
authors.lastname: d'Addedda
authors.forename: G
authors.initials: G
authors.lastname: Cappucci
authors.forename: G
authors.initials: G
authors.lastname: Vecchione
authors.forename: N
authors.initials: N
authors.lastname: Sciannamé
authors.forename: G
authors.initials: G
authors.lastname: Pavone
authors.forename: G
authors.initials: G
authors.lastname: Di Minno
mesh_terms: D000026:Abortion, Habitual / Q000453:epidemiology / Q000235:genetics*; D000328:Adult; D016022:Case-Control Studies; D016001:Confidence Intervals; D017931:DNA Primers; D005165:Factor V / Q000032:analysis* / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D006801:Humans; D007558:Italy; D008875:Middle Aged; D016017:Odds Ratio; D017354:Point Mutation; D016133:Polymerase Chain Reaction; D011247:Pregnancy; D044465:White People
chemical_list: D017931:DNA Primers; C095381:factor V Leiden; D005165:Factor V