title: [Changes in the nuclear morphometry in oropharyngeal epidermoid carcinoma after induction chemotherapy].
abstract: A cytomorphic, stereological study was made by computerized image analysis of six nuclear morphometric variables and one stereological nuclear variable. Variables were measured on 150 randomly selected tumor cells in oropharyngeal biopsies from 44 patients with oropharyngeal cancer who had not responded completely to induction chemotherapy. The nuclei of tumoral cells were larger (mean nuclear area, perimeter, and volume), more rounded, and had a less irregular nuclear contour index.
authors.affiliation: Servicio de Otorrinoiaringología y Patologia Cérvico-Facial, Hospital Universitario de Salamanca.
authors.forename: S
authors.initials: S
authors.lastname: Santa Cruz Ruiz
authors.forename: J L
authors.initials: JL
authors.lastname: Gómez González
authors.forename: T
authors.initials: T
authors.lastname: Flores Corral
authors.forename: A
authors.initials: A
authors.lastname: Del Cañizo Alvarez
mesh_terms: D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000473:pathology*; D002945:Cisplatin / Q000008:administration & dosage / Q000627:therapeutic use*; D005472:Fluorouracil / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002955:Leucovorin / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009959:Oropharyngeal Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D009960:Oropharynx / Q000473:pathology*; D012189:Retrospective Studies
chemical_list: D000970:Antineoplastic Agents; D007166:Immunosuppressive Agents; D002945:Cisplatin; D002955:Leucovorin; D005472:Fluorouracil