[The synergistic action of quaternary ammonium derivatives and inhibitors of nitrate reduction in respect to Pseudomonas aeruginosa].
It was revealed that ability of zink chloride, copper sulphate, aluminium nitrate and sodium chloride to inhibit the nitrate reduction of Pseudomonas correlated with their potentiating influence on the antimicrobial activity of decamethoxin, a quaternary ammonium derivative. So, doses of zink chloride (0.01-0.04%), copper sulphate (0.04%), aluminium nitrate (0.04%), sodium fluoride (0.05-0.1%) able to inhibit effectively the reduction of anions of nitric acid decreased the minimal inhibitory concentration of decamethoxin against Pseudomonas strain ATCC 27853 to 0.15-10 mg/ml and minimal bactericidal concentration to 0.20-10 mg/ml in comparison with 15.6 and 60.4 mg/ml in the control without potentiators. Providing the use of respiration chain's inhibiting doses of sodium fluoride (0.1%) and zink chloride (0.01%), it became possible to decrease the resistance of 54 clinical samples of Pseudomonas aeruginosa to decamethoxin.
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D000332:Aerobiosis / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004352:Drug Resistance, Microbial; D004357:Drug Synergism; D006801:Humans; D008826:Microbial Sensitivity Tests / Q000379:methods; D050901:Nitrate Reductase; D009565:Nitrate Reductases / Q000037:antagonists & inhibitors*; D010084:Oxidation-Reduction / Q000187:drug effects; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000302:isolation & purification / Q000378:metabolism; D000644:Quaternary Ammonium Compounds / Q000494:pharmacology*
D000644:Quaternary Ammonium Compounds; D009565:Nitrate Reductases; D050901:Nitrate Reductase