title: A case of Robinow syndrome accompanied by partial growth hormone insufficiency treated with growth hormone.
abstract: We report on a 10-year-old Japanese girl with Robinow syndrome accompanied by partial growth hormone (GH) insufficiency. We started GH replacement therapy at the chronological age of 6.5 years. In this case, improvement in the growth velocity was remarkable, but bone maturation accelerated even more. In order to avoid further acceleration of bone maturation, we started to treat our patient at the chronological age of 9.8 years with GH combined with gonadal suppression therapy using a luteinizing hormone releasing hormone analogue. However, no improvement in height SDS for bone age was attained. Our observations suggest that the indication of GH therapy for patients with Robinow syndrome needs careful consideration.
authors.affiliation: Department of Pediatrics, Faculty of Medicine, Kyoto University, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Kawai
authors.forename: T
authors.initials: T
authors.lastname: Yorifuji
authors.forename: C
authors.initials: C
authors.lastname: Yamanaka
authors.forename: H
authors.initials: H
authors.lastname: Sasaki
authors.forename: T
authors.initials: T
authors.lastname: Momoi
authors.forename: K
authors.initials: K
authors.lastname: Furusho
mesh_terms: D001827:Body Height; D001846:Bone Development; D002675:Child, Preschool; D004392:Dwarfism; D005147:Facial Bones / Q000002:abnormalities*; D005260:Female; D005836:Genitalia, Female / Q000002:abnormalities*; D019382:Human Growth Hormone / Q000172:deficiency* / Q000627:therapeutic use*; D006801:Humans; D016729:Leuprolide / Q000627:therapeutic use; D013577:Syndrome
chemical_list: D019382:Human Growth Hormone; D016729:Leuprolide