Avirulence of LT2 strains of Salmonella typhimurium results from a defective rpoS gene.
In order to identify the genetic basis for the attenuation of Salmonella typhimurium LT2 strains, experiments were performed to identify a gene(s) which restores virulence to an avirulent LT2 strain. These and further experiments confirmed that an rpoS mutation is the sole determinant of the attenuation of S. typhimurium LT2.
Swords
W E
WE
Department of Microbiology, University of Alabama at Birmingham, USA.
Cannon
B M
BM
Benjamin
W H
WH
D000483:Alleles; D001426:Bacterial Proteins / Q000235:genetics*; D005798:Genes, Bacterial; D009154:Mutation; D012486:Salmonella typhimurium / Q000235:genetics / Q000472:pathogenicity*; D012808:Sigma Factor / Q000235:genetics*; D014774:Virulence
D001426:Bacterial Proteins; D012808:Sigma Factor; C069567:sigma factor KatF protein, Bacteria