title: [Comparison between low-molecular and unfractionated heparin in the prevention of thrombosis in patients with total endoprosthetic replacement of hip and knee joint].
abstract: OBJECTIVE
  Thrombosis-prophylaxies with heparins after total hip arthroplasty (THP) and total knee arthroplasty (TKA) is well accepted. The aim of this study was to compare the low molecular weight heparin (Enoxaparin) with PTT adjusted unfractionated heparin (Na-heparin).
  
  
  METHODS
  In a prospective study of 226 patients after THA and TKA, we performed physical examination and ultrasound in compression and duplex technique one day before surgery and at the 7th and 14th day after surgery. 120 patients received Enoxaparin 1 x 40 mg per day in fixed dosage. 106 patients received Na-heparin 3 x 5000 IE. Since PTT did not reach 40 seconds, Na-heparin dosage was increased to 3 x 7500 IE.
  
  
  RESULTS
  The overall thrombosis rate was 4% (n = 9), in the Enoxaparin group 2.9% for the 70 THA and 10% for the 50 TKA. Thrombosis occurred in the group of unfractionated heparin (PTT adjusted) in 1.8% after THA and in 2% after TKA. In TKA, there is statistical difference between the two heparin groups.
  
  
  CONCLUSIONS
  In the thrombosis prophylaxis of TKA, PTT adjusted unfractionated heparin is superior to low molecular weight heparin in fixed dosage.
authors.affiliation: Orthopädische Universitätsklinik Würzburg.
authors.forename: C P
authors.initials: CP
authors.lastname: Rader
authors.forename: C
authors.initials: C
authors.lastname: Kramer
authors.forename: A
authors.initials: A
authors.lastname: König
authors.forename: F
authors.initials: F
authors.lastname: Gohlke
authors.forename: J
authors.initials: J
authors.lastname: Eulert
mesh_terms: D000368:Aged; D000925:Anticoagulants / Q000627:therapeutic use*; D017984:Enoxaparin / Q000627:therapeutic use*; D005260:Female; D006493:Heparin / Q000627:therapeutic use*; D006622:Hip Prosthesis; D006801:Humans; D007720:Knee Prosthesis; D008297:Male; D008875:Middle Aged; D010314:Partial Thromboplastin Time; D011183:Postoperative Complications / Q000097:blood / Q000517:prevention & control*; D011446:Prospective Studies; D013927:Thrombosis / Q000097:blood / Q000517:prevention & control*
chemical_list: D000925:Anticoagulants; D017984:Enoxaparin; D006493:Heparin