title: Post-ICU mechanical ventilation: treatment of 1,123 patients at a regional weaning center.
abstract: OBJECTIVE
  To update our database, reporting changes in the results of weaning attempts and profile of patients transferred to us after prolonged mechanical ventilation (PMV) in the ICU.
  
  
  METHODS
  Retrospective record review, with prospective recording of physiologic measurements on admission from mid-1994.
  
  
  METHODS
  Regional weaning center (RWC).
  
  
  METHODS
  We studied 1,123 consecutive ventilator-dependent patients transferred for attempted weaning over an 8-year period.
  
  
  RESULTS
  Median (range) time of mechanical ventilation prior to transfer to the RWC declined from 37 (1 to 249) days in 1988 to 29 (1 to 120) days in 1996 (p<0.05). Acute physiology score of acute physiology and chronic health evaluation (APACHE) III was 32 (6 to 123) on RWC admission, equaling reported scores soon after ICU admission. Comparing other data on admission from 1988 to 1996, mean (+/-SD) serum albumin level declined from 2.92+/-0.58 to 2.43+/-0.50 g/dL, and alveolar-arterial oxygen pressure difference widened from 106+/-50 to 139+/-99 mm Hg. Prevalence of stage II or worse pressure ulceration on admission increased from 34% in 1988 to 46% in 1995. Despite these trends, there has been no significant change in patient outcome (55.9% weaned, 15.6% failed to wean, 28.8% died) or in median time to wean (29 [1 to 226] days). Overall survival at 1 year after discharge for the 8-year period is 37.9%, improving from 29% in 1988-1991 to 45% since 1992; survival in weaned patients discharged to home has improved from 45 to 59% during the respective time periods.
  
  
  CONCLUSIONS
  Patients are being transferred from the ICU to our RWC for attempted weaning sooner in their course of PMV. Although more severely ill on arrival than in past years, mortality is unchanged, more than half of the patients continue to be successfully weaned, and survival after RWC discharge is improved.
authors.affiliation: Barlow Respiratory Hospital and Research Center, Los Angeles, CA 90026-2696, USA.
authors.forename: D J
authors.initials: DJ
authors.lastname: Scheinhorn
authors.forename: D C
authors.initials: DC
authors.lastname: Chao
authors.forename: M
authors.initials: M
authors.lastname: Stearn-Hassenpflug
authors.forename: L D
authors.initials: LD
authors.lastname: LaBree
authors.forename: D J
authors.initials: DJ
authors.lastname: Heltsley
mesh_terms: D018806:APACHE; D000368:Aged; D000369:Aged, 80 and over; D016009:Chi-Square Distribution; D003422:Critical Care; D005260:Female; D006801:Humans; D015141:Los Angeles; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012121:Respiration, Artificial / Q000706:statistics & numerical data; D012189:Retrospective Studies; D018709:Statistics, Nonparametric; D013997:Time Factors; D016896:Treatment Outcome; D015300:Ventilator Weaning / Q000706:statistics & numerical data