Leukocyte crosstalk at the vascular wall.
P-selectin is an adhesion molecule on platelets and endothelial cells that mediates the interaction of these cells with leukocytes. In addition to its docking function in cell-cell recognition, P-selectin is involved in cell signalling and cell communication. Upon platelet activation, P-selectin undergoes rapid phosphorylation and dephosphorylation. The biological role of these phosphorylation events within platelets is unknown. P-selectin, upon contact with its receptor on monocytes, initiates the de novo biosynthesis of tissue factor and other cytokines. Tissue factor upregulation on monocytes is mediated by PSGL-1 and is independent of CD14, the LPS receptor.
Furie
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B
Division of Hematology-Oncology, New England Medical Center, Boston, MA 02111, USA. bfurie@earl.hemonc.nemc.org
Furie
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BC
D000818:Animals; D004730:Endothelium, Vascular / Q000502:physiology*; D006801:Humans; D007962:Leukocytes / Q000502:physiology*; D008958:Models, Molecular; D009000:Monocytes / Q000502:physiology; D019007:P-Selectin / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology; D013925:Thromboplastin / Q000502:physiology; D015854:Up-Regulation
D019007:P-Selectin; D013925:Thromboplastin