Cardiovascular effects of the fungal extract of basidiomycetes sp. YL8006.
Many fungal products are known to possess biological activity towards the mammalian tissues. We studied vasodilating activity in the crude ethanol extract of the dried mycelia of Basidiomycetes sp. YL8006, cultured by submerged fermentation with a complex medium. The activity was assayed using the isolated perfused rat heart in the working mode. Immediately following injection of the extract into the perfusion system, a 20-25% increase in coronary flow was observed (p<0.001 vs. solvent vehicle control). There was a concurrent decrease in diastolic pressure and coronary vascular resistance. Aortic flow, systolic pressure, and cardiac output declined slightly over time after treatment. No significant changes in heart rate, efficiency, and oxygen consumption were observed. Solvent vehicle did not cause any changes in hemodynamic performance.
Andreacchi
A S
AS
Department of Chemical Engineering; University of Rochester, New York 14627, USA.
Wang
T
T
Wu
J H
JH
D000818:Animals; D001487:Basidiomycota / Q000737:chemistry*; D002317:Cardiovascular Agents / Q000302:isolation & purification / Q000494:pharmacology*; D002851:Chromatography, High Pressure Liquid; D006439:Hemodynamics / Q000187:drug effects; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012039:Regional Blood Flow / Q000187:drug effects
D002317:Cardiovascular Agents