title: Surveillance of patients with Barrett's esophagus for dysplasia and cancer with balloon cytology.
abstract: OBJECTIVE
  A less costly cancer surveillance method for Barrett's esophagus is desirable. The aim of this study was to compare nonendoscopic balloon cytology with biopsy and brush cytology for detecting dysplasia and carcinoma in patients with Barrett's esophagus.
  
  
  METHODS
  Patients in a surveillance program underwent balloon cytology before endoscopy with biopsy and brush cytology. Results of cytology were compared with those of histology.
  
  
  RESULTS
  Adequate columnar epithelium was obtained in 52 of 63 (83%) patients with balloon cytology and 59 of 61 (97%) with brush cytology. Balloon cytology obtained abnormal cells in 6 of 8 patients with adenocarcinoma, 2 of 2 patients with high-grade dysplasia, and 2 of 8 patients with low-grade dysplasia. Sensitivity of balloon cytology for high-grade dysplasia or carcinoma was 80% but only 25% for low-grade dysplasia. No patients without dysplasia or carcinoma had abnormal cells. Brush cytology was abnormal in all 11 patients with high-grade dysplasia or carcinoma but only 2 of 9 patients with low-grade dysplasia (sensitivity, 22%). Two of 39 patients without dysplasia had abnormal cells (specificity, 95%). Balloon cytology cost was sixfold less than endoscopy with biopsy.
  
  
  CONCLUSIONS
  Balloon cytology detected 80% of patients with high-grade dysplasia or carcinoma when sampling was adequate. Brush cytology data suggest that a more abrasive balloon may improve balloon cytology sensitivity. The potential cost savings of balloon cytology compared with endoscopic cancer surveillance in Barrett's esophagus support further studies of this technique.
authors.affiliation: Department of Gastroenterology, The Cleveland Clinic, Ohio 44195, USA.
authors.forename: G W
authors.initials: GW
authors.lastname: Falk
authors.forename: R
authors.initials: R
authors.lastname: Chittajallu
authors.forename: J R
authors.initials: JR
authors.lastname: Goldblum
authors.forename: C V
authors.initials: CV
authors.lastname: Biscotti
authors.forename: K R
authors.initials: KR
authors.lastname: Geisinger
authors.forename: R E
authors.initials: RE
authors.lastname: Petras
authors.forename: S
authors.initials: S
authors.lastname: Birgisson
authors.forename: T W
authors.initials: TW
authors.lastname: Rice
authors.forename: J E
authors.initials: JE
authors.lastname: Richter
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001471:Barrett Esophagus / Q000473:pathology*; D002404:Catheterization; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000473:pathology*