title: Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1.
abstract: Extracellular levels of the excitatory neurotransmitter glutamate in the nervous system are maintained by transporters that actively remove glutamate from the extracellular space. Homozygous mice deficient in GLT-1, a widely distributed astrocytic glutamate transporter, show lethal spontaneous seizures and increased susceptibility to acute cortical injury. These effects can be attributed to elevated levels of residual glutamate in the brains of these mice.
authors.affiliation: Department of Degenerative Neurological Diseases, National Institute of Neuroscience, Kodaira, Tokyo 187, Japan. tanaka@ncnaxp.ncap.go.jp
authors.forename: K
authors.initials: K
authors.lastname: Tanaka
authors.forename: K
authors.initials: K
authors.lastname: Watase
authors.forename: T
authors.initials: T
authors.lastname: Manabe
authors.forename: K
authors.initials: K
authors.lastname: Yamada
authors.forename: M
authors.initials: M
authors.lastname: Watanabe
authors.forename: K
authors.initials: K
authors.lastname: Takahashi
authors.forename: H
authors.initials: H
authors.lastname: Iwama
authors.forename: T
authors.initials: T
authors.lastname: Nishikawa
authors.forename: N
authors.initials: N
authors.lastname: Ichihara
authors.forename: T
authors.initials: T
authors.lastname: Kikuchi
authors.forename: S
authors.initials: S
authors.lastname: Okuyama
authors.forename: N
authors.initials: N
authors.lastname: Kawashima
authors.forename: S
authors.initials: S
authors.lastname: Hori
authors.forename: M
authors.initials: M
authors.lastname: Takimoto
authors.forename: K
authors.initials: K
authors.lastname: Wada
mesh_terms: D018528:ATP-Binding Cassette Transporters / Q000235:genetics / Q000378:metabolism*; D027322:Amino Acid Transport System X-AG; D000818:Animals; D001692:Biological Transport; D001921:Brain / Q000378:metabolism* / Q000473:pathology; D001930:Brain Injuries / Q000378:metabolism* / Q000473:pathology; D004569:Electroencephalography; D004827:Epilepsy / Q000378:metabolism* / Q000473:pathology; D018390:Gene Targeting; D018698:Glutamic Acid / Q000378:metabolism*; D006624:Hippocampus / Q000378:metabolism / Q000473:pathology; D051379:Mice; D008810:Mice, Inbred C57BL; D009410:Nerve Degeneration; D017966:Pyramidal Cells / Q000473:pathology / Q000502:physiology; D013569:Synapses / Q000378:metabolism; D009435:Synaptic Transmission
chemical_list: D018528:ATP-Binding Cassette Transporters; D027322:Amino Acid Transport System X-AG; D018698:Glutamic Acid