title: The role of leukocyte and endothelial adhesion molecules in ischemia-reperfusion injury.
abstract: Reperfusion of ischemic tissue is associated with an acute inflammatory response that may further exacerbate vascular and tissue damage. Compelling evidence from a variety of animal models indicates that neutrophils are the principle effector cells of the reperfusion injury and that blockade of neutrophil adhesion to endothelium attenuates ischemia-reperfusion injury. "Anti-adhesion" therapy may represent a new approach to treatment of the many diverse clinical disorders in which ischemia-reperfusion occurs.
authors.affiliation: Department of Anesthesia & Critical Care, University of Washington, Children's Hospital & Medical Center, Seattle, USA.
authors.forename: R R
authors.initials: RR
authors.lastname: Thiagarajan
authors.forename: R K
authors.initials: RK
authors.lastname: Winn
authors.forename: J M
authors.initials: JM
authors.lastname: Harlan
mesh_terms: D000818:Animals; D015815:Cell Adhesion Molecules / Q000502:physiology*; D004730:Endothelium, Vascular / Q000502:physiology*; D006801:Humans; D007136:Immunoglobulins / Q000502:physiology; D016023:Integrins / Q000502:physiology; D007962:Leukocytes / Q000502:physiology*; D009504:Neutrophils / Q000502:physiology; D015427:Reperfusion Injury / Q000097:blood / Q000503:physiopathology*; D019087:Selectins / Q000502:physiology*
chemical_list: D015815:Cell Adhesion Molecules; D007136:Immunoglobulins; D016023:Integrins; D019087:Selectins