[Evaluation of results from radiotherapy and combined treatment of laryngeal cancer (surgery and radiotherapy) considering differentiation of procedures with respect to lymph nodes in the neck].
The aim of the work was to estimate the therapeutic results in patients with laryngeal cancer treated by combined method (surgery and radiotherapy) and radiotherapy alone. In the group of patients treated by combined method the randomised clinical study, concerning regional lymph nodes arrangement, has been performed (Tab. 5). The control group of patients was treated, as before, by radical neck dissection (RND), or modified neck dissection (MND), or regional modified neck dissection (RMND), depending on the advancement of the tumor and lymph nodes involvement, combined with moderate postoperative dose of irradiation (5000-5500 cGy). Adversely, the study group was subjected to more conservative surgery, namely MND, or RMND, or LAC (lymphadenectomy) combined with postoperative, slightly higher, dose of irradiation (5500-6000 cGy) (Tab. 6). Clinical material of 213 patients, treated between 1986-1990 at the Laryngology Department and Radiotherapy Department of Pomeranian Medical Academy, has been analysed. There were 84 patients in the study group, 68 in the control group, and 61 in exclusively irradiated group. The patients treated only surgically as well as those irradiated palliatively were excluded. The best results of treatment have been obtained in the study group (3-year survival 78%, and 5-year survival 69%), worse in the control group (3-year survival 62%, and 5-year survival 51%) and the worst in the exclusively irradiated group (3-year 51%, and 5-year 44%) (Fig. 4). The most frequent cause of failure was local and loco regional relapse. The acute and late radiation morbidity, according to RTOG/EORTC classification, has been also analysed. In the majority of patients only slight and moderate (1 and 2 grade), in some patients 3 grade, and in 2 patients 4 grade morbidity has been observed.
Rogowska
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Kliniki Radioterapii Instytutu Radiologii Pomorskiej Akademii Medycznej w Szczecinie.
D000328:Adult; D000368:Aged; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery*; D008197:Lymph Node Excision / Q000379:methods*; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009333:Neck; D009367:Neoplasm Staging; D011879:Radiotherapy Dosage; D015996:Survival Rate; D016896:Treatment Outcome