title: Colonic transit time in patients with myelomeningocele.
abstract: To evaluate colonic motility in patients with myelomeningocele, the transit time of radiopaque markers was studied in 22 patients with myelomeningocele and 22 age and sex matched controls. Mean colonic transit time was significantly longer in patients than in controls (103.2 +/- 49 h versus 23.3 +/- 13 h; P < 10(-7). Thirteen of 22 patients with myelomeningocele were severely constipated. Six patients had constipation secondary to delayed colonic transit, particularly in the left colon, and seven had increased rectosigmoid transit. The clinical questionnaire and particularly the frequency of bowel movements did not predict colonic transit. Among 13 patients with increased colonic transit, eight had more than five bowel movements per week and, thus, six of them did not use laxatives or enemas, despite the presence of faecal incontinence. There was no relationship between colonic transit time and the level of the spinal lesion or patient mobility in patients with myelomeningocele. Rectoanal dyssynergia was found in 14 of the 22 patients, but equally often in patients with delayed rectosigmoid transit (4/7) as in the other patients (10/15) (P = ns). Uninhibited detrusor contractions were observed more often in patients with increased colonic transit time than in others (8/12 versus 1/8, P = 0.05). In the absence of a correlation between colonic transit time, clinical symptoms, anorectal motility, level of spinal lesion, patient mobility, evaluation of colonic transit of radiopaque markers should be assessed routinely in all patients with myelomeningocele to plan the most appropriate treatment, mainly in case of unhibited detrusor contractions.
authors.affiliation: Département de Pédiatrie, Faculté de Médecine, Université de Sherbrooke, Québec, Canada.
authors.forename: N
authors.initials: N
authors.lastname: Pigeon
authors.forename: A M
authors.initials: AM
authors.lastname: Leroi
authors.forename: G
authors.initials: G
authors.lastname: Devroede
authors.forename: A
authors.initials: A
authors.lastname: Watier
authors.forename: P
authors.initials: P
authors.lastname: Denis
authors.forename: J
authors.initials: J
authors.lastname: Weber
authors.forename: P
authors.initials: P
authors.lastname: Arhan
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D002648:Child; D003106:Colon / Q000502:physiology*; D005260:Female; D005772:Gastrointestinal Transit; D006801:Humans; D008297:Male; D008365:Manometry; D008591:Meningomyelocele / Q000503:physiopathology*; D011795:Surveys and Questionnaires