[Microalbuminuria as predictor of atherosclerotic cardiovascular disease in IDDM].
The aim of this follow-up study was to assess whether slightly elevated urinary albumin excretion, i.e., microalbuminuria, precedes development of atherosclerotic vascular disease in IDDM. Out of 259 IDDM-patients 30 developed vascular disease during 2,457 person-years. Microalbuminuria was significantly predictive of vascular disease (hazard ratio (95% confidence interval) 1.06 (1.02-1.18) per 5 mg/24 hours increase in urinary albumin excretion; p = 0.002). The predictive effect was independent of age, sex, blood pressure, tobacco smoking, serum concentrations of total-cholesterol, HDL-cholesterol, sialic acid, and von Willebrand factor, and of haemoglobin A1c, insulin dose, diabetes duration, and diabetic nephropathy (hazard ratio (95% confidence interval) 1.04 (1.01-1.08) per 5 mg/24 hours increase in urinary albumin excretion; p = 0.03). It is concluded that slightly elevated urinary albumin excretion is an independent predictor of atherosclerotic vascular disease in insulin-dependent diabetes mellitus.
Deckert
T
T
Steno Diabetes Center, Gentofte.
Yokoyama
H
H
Mathiesen
E R
ER
Rønn
B
B
Jensen
T J
TJ
Feldt-Rasmussen
B F
BF
Borch-Johnsen
K
K
Jensen
J S
JS
D000328:Adult; D000419:Albuminuria / Q000175:diagnosis*; D001161:Arteriosclerosis / Q000209:etiology* / Q000652:urine; D015331:Cohort Studies; D003922:Diabetes Mellitus, Type 1 / Q000150:complications* / Q000652:urine; D003925:Diabetic Angiopathies / Q000209:etiology* / Q000652:urine; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D011379:Prognosis