[The dependence of the frequency of stable and unstable chromosome aberrations on the dose of the irradiation of human lymphocytes in vitro].
Two methods (FISH and Giemsa) were used to estimate the frequency of stable and unstable chromosome aberrations in human lymphocytes exposed to gamma-irradiation in vitro in the dose range of 0.1 to 1.5 Gy. The DNA-probes specific to the chromosomes 1, 4, and 12 were used in combination with a pancentromeric probe. It was revealed that the dose-effect dependences for translocations (FISH) and dicentrics (FISH and Giemsa) were similar and could be adequately described by a linear-quadratic function.
Vorobtsova
I E
IE
Vorob'eva
M V
MV
Bogomazova
A N
AN
Timofeeva
N M
NM
Efremova
T N
TN
Piukkenen
A Iu
AIu
D000328:Adult; D001399:Azure Stains; D002478:Cells, Cultured; D016009:Chi-Square Distribution; D002869:Chromosome Aberrations; D002871:Chromosome Banding / Q000706:statistics & numerical data; D002878:Chromosomes, Human, Pair 1 / Q000528:radiation effects*; D002881:Chromosomes, Human, Pair 12 / Q000528:radiation effects*; D002894:Chromosomes, Human, Pair 4 / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D005260:Female; D005720:Gamma Rays; D006801:Humans; D017404:In Situ Hybridization, Fluorescence / Q000706:statistics & numerical data; D008214:Lymphocytes / Q000528:radiation effects* / Q000648:ultrastructure; D014178:Translocation, Genetic / Q000528:radiation effects
D001399:Azure Stains