title: Clinical relevance of Fc gamma receptor polymorphisms.
abstract: Human IgG receptors are very heterogeneous and we currently distinguish three Fc gamma receptor classes specifying at least 12 receptor isoforms. On top of this complexity, Fc gamma R are further found to differ between different individuals. Polymorphisms have been identified for all three Fc gamma R classes. The best-studied ones represent allelic variation of Fc gamma RIIa (CD32) and Fc gamma RIIIb (CD16). The Fc gamma RIIa polymorphism is now considered to be a heritable risk factor for autoimmune and infectious diseases, and support for a relevant role of the IIIb polymorphism has also been obtained. A detailed analysis of the exact contribution of each of these Fc gamma R polymorphisms in relation to previously implicated risk factors should unravel the pathophysiological importance of Fc gamma R polymorphisms in the near future.
authors.affiliation: Department of Medicine III, University Hospital Erlangen, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Rascu
authors.forename: R
authors.initials: R
authors.lastname: Repp
authors.forename: N A
authors.initials: NA
authors.lastname: Westerdaal
authors.forename: J R
authors.initials: JR
authors.lastname: Kalden
authors.forename: J G
authors.initials: JG
authors.lastname: van de Winkel
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D001327:Autoimmune Diseases / Q000235:genetics*; D014890:Granulomatosis with Polyangiitis / Q000235:genetics; D006493:Heparin; D006801:Humans; D016030:Kidney Transplantation; D008180:Lupus Erythematosus, Systemic / Q000235:genetics; D051379:Mice; D008958:Models, Molecular; D011110:Polymorphism, Genetic; D017452:Receptors, IgG / Q000235:genetics* / Q000276:immunology; D013921:Thrombocytopenia / Q000235:genetics
chemical_list: D000911:Antibodies, Monoclonal; D017452:Receptors, IgG; D006493:Heparin