NF00659A1, A2, A3, B1 and B2, novel antitumor antibiotics produced by Aspergillus sp. NF 00659. II. Structural elucidation.
NF00659A1, A2, A3, B1 and B2, having insecticidal and antitumor activities, were isolated from a culture mycelium of Aspergillus sp. NF 00659. The novel structure of NF00659s were determined mainly by spectroscopic studies including various NMR measurements. NF00659s have a common structure which consists of acyl, alpha-pyrone and 4,5-seco-tricyclic diterpene moieties.
Suzuki
K
K
Applied Microbiology Research Center, Nippon Kayaku Co., Ltd., Saitama, Japan.
Kuwahara
A
A
Nishikiori
T
T
Nakagawa
T
T
D000903:Antibiotics, Antineoplastic / Q000737:chemistry*; D004224:Diterpenes / Q000737:chemistry*; D007306:Insecticides / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D011753:Pyrones / Q000737:chemistry*
D000903:Antibiotics, Antineoplastic; D004224:Diterpenes; D007306:Insecticides; D011753:Pyrones