Levels of dynorphin peptides in the central nervous system and pituitary gland of the spontaneously hypertensive rat.
The levels of dynorphin A-like immunoreactivity (Dyn A-LI) and dynorphin B-like immunoreactivity (Dyn B-LI) were determined in various regions of brain, spinal cord and pituitary gland in spontaneously hypertensive rats (SHRs) as compared with the normotensive Wistar-Kyoto rats (WKYs). SHRs had significantly lower levels of Dyn A-LI and Dyn B-LI in the neurointermediate pituitary lobe and in the hippocampus. Conversely, the levels of Dyn A-LI and Dyn B-LI were higher in the hypothalamus, striatum and periaqueductal gray of the SHRs.
Tan-No
K
K
Department of Pharmacology, Tohoku College of Pharmacy, Sendai, Japan.
Terenius
L
L
Silberring
J
J
Nylander
I
I
D000818:Animals; D015415:Biomarkers / Q000737:chemistry; D001921:Brain / Q000378:metabolism*; D004399:Dynorphins / Q000378:metabolism*; D004723:Endorphins / Q000378:metabolism*; D004745:Enkephalins / Q000378:metabolism; D006973:Hypertension / Q000378:metabolism*; D007150:Immunohistochemistry; D008161:Lumbosacral Region; D008297:Male; D010902:Pituitary Gland / Q000378:metabolism*; D011498:Protein Precursors / Q000378:metabolism; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D013116:Spinal Cord / Q000378:metabolism*
D015415:Biomarkers; D004723:Endorphins; D004745:Enkephalins; D011498:Protein Precursors; D004399:Dynorphins; C036200:rimorphin; C033660:preproenkephalin