title: Protection of the maternal and fetal thyroid from radioactive contamination by the administration of stable iodide during pregnancy. An experimental evaluation in chimpanzees.
abstract: The safety and efficacy of the administration of stable iodide to protect the fetal thyroid from exposure to radioactive iodide were investigated in chimpanzees in weeks 19 to 21 of pregnancy. The mean 24-h uptake of iodide in the fetal thyroid, determined with 123I-, was 1.8%. Administration of stable potassium iodide (KI), 0.65, 1.95 or 6.5 mg per kg body weight, 1 h before tracer injection reduced the fetal uptake satisfactorily. Only the higher doses were effective after 20 h. Excess iodide may impair a child's thyroid status. However, adverse effects were not found during the 11 days the animals ingested these doses. Tracer concentrations in the amniotic fluid were 30- to 130-fold lower than in the urine. The dose to the fetus from radioactivity in the maternal bladder was estimated by computer simulation. The potential increment of the risk from this dose during the ingestion of stable iodide is smaller than the reduction of risk achieved by inhibiting the uptake of radioactive iodide by the fetal thyroid. The conclusion of the experiments is that stable iodide can be used safely and effectively to protect the fetal thyroid against contamination with radioactive iodine.
authors.affiliation: Comprehensive Cancer Center, Rotterdam, The Netherlands.
authors.forename: J L
authors.initials: JL
authors.lastname: Noteboom
authors.forename: W A
authors.initials: WA
authors.lastname: Hummel
authors.forename: J J
authors.initials: JJ
authors.lastname: Broerse
authors.forename: J J
authors.initials: JJ
authors.lastname: de Vijlder
authors.forename: T
authors.initials: T
authors.lastname: Vulsma
authors.forename: J T
authors.initials: JT
authors.lastname: Jansen
authors.forename: D W
authors.initials: DW
authors.lastname: van Bekkum
mesh_terms: D000818:Animals; D005260:Female; D005333:Fetus / Q000528:radiation effects*; D007457:Iodine Radioisotopes / Q000493:pharmacokinetics*; D002679:Pan troglodytes; D011193:Potassium Iodide / Q000493:pharmacokinetics / Q000494:pharmacology*; D011247:Pregnancy; D011835:Radiation Protection; D013961:Thyroid Gland / Q000502:physiology / Q000528:radiation effects*
chemical_list: D007457:Iodine Radioisotopes; D011193:Potassium Iodide