[Toxic properties of recombinant tumor necrosis factor].
Toxic properties of recombinant human tumor necrosis factor (TNF-beta) were studied on noninbred albino mice. In the maximum tolerable doses the preparation induced a decrease in the body weight and temperature of the animals as well as development of glyco- and leukopenic reactions and damage of the internal organ structures. The preparation effects were observed early after the exposure and were mainly reversible. The most TNF-beta sensitive organs were the liver, lungs, adrenal gland, thymus and spleen. The major link in the pathological process development under the effect of the TNF-beta toxic doses was likely increased intravascular blood coagulability evident from a marked procoagulant activity of the preparation.
Masycheva
V I
VI
Danilenko
E D
ED
Morozova
E N
EN
Fedosova
L K
LK
Sizova
L Iu
LIu
Gamaleĭ
S G
SG
Lebedev
L R
LR
Pustoshilova
N M
NM
D000818:Animals; D001778:Blood Coagulation Disorders / Q000139:chemically induced; D001786:Blood Glucose / Q000378:metabolism; D001833:Body Temperature Regulation / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D002460:Cell Line; D006403:Hematologic Tests; D006801:Humans; D007962:Leukocytes / Q000187:drug effects; D008233:Lymphotoxin-alpha / Q000633:toxicity*; D051379:Mice; D009928:Organ Specificity; D011994:Recombinant Proteins / Q000633:toxicity
D001786:Blood Glucose; D008233:Lymphotoxin-alpha; D011994:Recombinant Proteins