Lack of CD54 expression and mutation of p53 gene relate to the prognosis of childhood Burkitt's lymphoma.
Expression of the intercellular adhesion molecule-1 (CD54) as well as the mutations of p53 gene were studied in childhood Burkitt's lymphoma (BL). Expression of CD54 was identified in 6 of 15 fresh BL cases. Mutations of p53 gene, analyzed by polymerase chain reaction-single stranded chain polymorphism followed by sequencing, were found in 5 of 14 cases examined. Interestingly, all the cases with p53 mutation were CD54 negative. This high frequency of p53 mutation in the CD54 negative group prompted us to analyze the clinical features of these cases. Six of 15 cases died within 21 months after initiation of therapy and five of these were CD54 negative. In addition, four of these had p53 mutation. These results suggest that the lack of CD54 by BL cells may provide the background for the mutation of p53 gene to occur which could result in the transformation to a more aggressive phenotype.
Kaneko
H
H
Department of Pathology, National Children's Medical Research Center, Tokyo, Japan.
Sugita
K
K
Kiyokawa
N
N
Iizuka
K
K
Takada
K
K
Saito
M
M
Yoshimoto
K
K
Itakura
M
M
Kokai
Y
Y
Fujimoto
J
J
D000293:Adolescent; D002051:Burkitt Lymphoma / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D002448:Cell Adhesion; D002648:Child; D002675:Child, Preschool; D003062:Codon / Q000235:genetics; D004252:DNA Mutational Analysis; D004273:DNA, Neoplasm / Q000235:genetics; D018450:Disease Progression; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D016158:Genes, p53; D006801:Humans; D016130:Immunophenotyping; D018799:Intercellular Adhesion Molecule-1 / Q000096:biosynthesis* / Q000235:genetics; D008297:Male; D009363:Neoplasm Proteins / Q000096:biosynthesis* / Q000235:genetics; D017354:Point Mutation; D016133:Polymerase Chain Reaction; D018807:Polymorphism, Single-Stranded Conformational; D011379:Prognosis; D012189:Retrospective Studies; D016019:Survival Analysis
D003062:Codon; D004273:DNA, Neoplasm; D009363:Neoplasm Proteins; D018799:Intercellular Adhesion Molecule-1