Dopamine D1 and D2 antagonists block L-DOPA-induced air-stepping in decerebrate neonatal rats.
L-DOPA administered to neonatal rats suspended in air elicits stereotypic locomotor activation termed air-stepping; it can be dose-dependently blocked by a dopamine (DA) D1 or D2 antagonist. In order to determine whether the forebrain is the site for this blockade, decerebrate 5-day-old rats were pretreated subcutaneously with either the DA D1 receptor antagonist SCH 23390 (16 mg/kg), the DA D2 receptor antagonist spiperone (6 mg/kg), or vehicle before receiving 100 mg/kg L-DOPA. Both antagonists blocked L-DOPA-induced air-stepping in both decerebrate and intact pups.
McCrea
A E
AE
Department of Psychology, University of Florida, Gainesville 32611-2250, USA.
Stehouwer
D J
DJ
Van Hartesveldt
C
C
D000818:Animals; D000831:Animals, Newborn; D001552:Benzazepines / Q000494:pharmacology*; D003655:Decerebrate State; D065127:Dopamine D2 Receptor Antagonists; D007980:Levodopa / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D009043:Motor Activity / Q000187:drug effects*; D051381:Rats; D017447:Receptors, Dopamine D1 / Q000037:antagonists & inhibitors*; D013134:Spiperone / Q000494:pharmacology*; D013239:Stereotyped Behavior / Q000187:drug effects*
D001552:Benzazepines; D065127:Dopamine D2 Receptor Antagonists; D017447:Receptors, Dopamine D1; D007980:Levodopa; D013134:Spiperone