Cyclic octapeptides from Stellaria dichotoma var. lanceolata.
Two new cyclic octapeptides, dichotomin H, cyclo(-Ala-Pro-Thr-Phe-Tyr-P ro-Leu-Ile-), and dichotomin I, cyclo(-Val-Pro-Thr-Phe-Tyr-Pro-Leu-Ile-) have been isolated from the roots of Stellaria dichotoma L. var lanceolata Bge., and their structures were elucidated by extensive two-dimensional NMR methods and chemical degradation.
Morita
H
H
Department of Pharmacognosy, School of Pharmacy, Tokyo University of Pharmacy and Life Science, Japan.
Takeya
K
K
Itokawa
H
H
D000595:Amino Acid Sequence; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification; D016861:Cyclooxygenase Inhibitors / Q000737:chemistry / Q000302:isolation & purification; D007941:Leukemia P388 / Q000473:pathology; D051379:Mice; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification*; D018517:Plant Roots / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry*; D013057:Spectrum Analysis; D014407:Tumor Cells, Cultured
D000972:Antineoplastic Agents, Phytogenic; D016861:Cyclooxygenase Inhibitors; D010456:Peptides, Cyclic; C106971:dichotomin H; C106972:dichotomin I