Mitochondrial fatty acid synthesis: a relic of endosymbiontic origin and a specialized means for respiration.
Genes that encode mitochondrial homologues to the bacterial enzymes of fatty acid synthesis were found in various eukaryotic species. Inactivation of these genes leads to a disturbed mitochondrial respiration and an increase in mitochondrial lysophospholipids. We postulate that there is a mitochondrial biosynthetic system providing fatty acids for phospholipid repair. The mitochondrial acyl carrier protein may also play another role, supporting the formation of the respiratory NADH:ubiquinone oxidoreductase.
Schneider
R
R
Institut für Biochemie, Heinrich-Heine-Universität Düsseldorf, Germany. Regina.Schneider@uni-duesseldorf.de
Brors
B
B
Massow
M
M
Weiss
H
H
D015099:3-Oxoacyl-(Acyl-Carrier-Protein) Synthase / Q000235:genetics / Q000378:metabolism; D000213:Acyl Carrier Protein / Q000235:genetics / Q000378:metabolism; D000818:Animals; D042967:Electron Transport Complex I; D005227:Fatty Acids / Q000096:biosynthesis*; D006801:Humans; D008928:Mitochondria / Q000235:genetics / Q000378:metabolism*; D008969:Molecular Sequence Data; D009245:NADH Dehydrogenase / Q000378:metabolism; D009247:NADH, NADPH Oxidoreductases / Q000378:metabolism; D010101:Oxygen Consumption; D010743:Phospholipids / Q000378:metabolism; D010802:Phylogeny; D013559:Symbiosis
D000213:Acyl Carrier Protein; D005227:Fatty Acids; D010743:Phospholipids; D009247:NADH, NADPH Oxidoreductases; D009245:NADH Dehydrogenase; D015099:3-Oxoacyl-(Acyl-Carrier-Protein) Synthase; D042967:Electron Transport Complex I