title: Relationship between the effects of a hypnotic drug, zopiclone, on polysomnography and on daytime EEGs.
abstract: The correlation between the effects of zopiclone (ZPC), a nonbenzodiazepine hypnotic drug, on sleep polysomnograms and on daytime EEGs was examined in 12 healthy adult male volunteers. Sleep polysomnograms were recorded after a single oral administration of ZPC 10 mg or placebo according to the double-blind crossover method. Daytime EEGs were recorded after the administration of ZPC, 7.5 mg, or placebo in the same manner, and recorded for 3 min with closed eyes at rest. Then, square roots of the absolute power (amplitude) of the delta-, theta-, alpha-, and beta-activities were calculated from the power spectrum obtained by the fast Fourier transform method. As a result, ZPC decreased the percentage of stage 1 sleep in total sleep time, while it increased the percentage of stage 2, total sleep time, and time of slow wave sleep in the first and second sleep cycles (SWS 1 and 2). Changes in SWS 1 and 2 correlated positively with the amplitude changes in daytime resting delta-activity. This indicates that the increase of SWS due to ZPC could be related to the change of delta-activity in the daytime resting EEG.
authors.affiliation: Department of Neuropsychiatry, Nippon Medical School, Tokyo, Japan. yamadera@nms.ac.jp
authors.forename: H
authors.initials: H
authors.lastname: Yamadera
authors.forename: M
authors.initials: M
authors.lastname: Kato
authors.forename: Y
authors.initials: Y
authors.lastname: Tsukahara
authors.forename: N
authors.initials: N
authors.lastname: Kajimura
authors.forename: T
authors.initials: T
authors.lastname: Okuma
mesh_terms: D000328:Adult; D053961:Azabicyclo Compounds; D004569:Electroencephalography / Q000187:drug effects*; D006801:Humans; D006993:Hypnotics and Sedatives / Q000494:pharmacology*; D008297:Male; D010879:Piperazines / Q000494:pharmacology*; D017286:Polysomnography / Q000187:drug effects*; D012890:Sleep / Q000187:drug effects*
chemical_list: D053961:Azabicyclo Compounds; D006993:Hypnotics and Sedatives; D010879:Piperazines; C515050:zopiclone