[Changes in the state of monooxygenase system and lipid peroxidation under the effects of carcinogenic dust].
The work was aimed to study relationship of monooxygenase system and lipid peroxidation in experiments and in clinical group. The examinees were workers engaged into graphite ware production and exposed to low fibrogenic dust of coke and graphite with carcinogens (including 3,4-benzpyrene). The experimental data and examination materials prove the carcinogens to alter seriously those systems. Long stimulation of monooxygenase system and activation of lipid peroxidation could result in more intensive carcinogenic effects of polycyclic aromatic hydrocarbons being a component of coal pitch.
Kuz'mina
L P
LP
Bezrukavnikova
L M
LM
Arkhipova
O G
OG
Kasparov
A A
AA
D000633:Aminopyrine N-Demethylase / Q000378:metabolism; D000815:Aniline Hydroxylase / Q000378:metabolism; D000818:Animals; D001564:Benzo(a)pyrene / Q000633:toxicity; D001991:Bronchitis / Q000139:chemically induced / Q000209:etiology*; D002273:Carcinogens / Q000633:toxicity*; D003077:Coke / Q000633:toxicity*; D003577:Cytochrome P-450 Enzyme System / Q000187:drug effects* / Q000378:metabolism; D004391:Dust / Q000009:adverse effects*; D006108:Graphite / Q000633:toxicity*; D006801:Humans; D066298:In Vitro Techniques; D015227:Lipid Peroxidation / Q000187:drug effects*; D009784:Occupational Diseases / Q000139:chemically induced / Q000209:etiology*; D011084:Polycyclic Aromatic Hydrocarbons / Q000633:toxicity; D051381:Rats; D017208:Rats, Wistar
D002273:Carcinogens; D003077:Coke; D004391:Dust; D011084:Polycyclic Aromatic Hydrocarbons; D001564:Benzo(a)pyrene; D006108:Graphite; D003577:Cytochrome P-450 Enzyme System; D000815:Aniline Hydroxylase; D000633:Aminopyrine N-Demethylase