title: Effect of the sulfonylurea glyburide on superoxide dismutase in streptozotocin-induced diabetic rat muscle.
abstract: 1. The effect of glyburide (glibenclamide) treatment on the muscle superoxide dismutase (SOD) activity of diabetic rats has been studied. 2. Four weeks of treatment with glyburide (5 mg/kg, orally) increased muscle SOD activity and decreased blood glucose levels. 3. The results of this study demonstrate that the sulfonylurea, glyburide, is capable of exerting direct insulin-like effects on muscle SOD activity in vivo.
authors.affiliation: Department of Biochemistry, Faculty of Medicine, University of Gazi, Beşevler, Ankara, Turkey.
authors.forename: N
authors.initials: N
authors.lastname: Altan
authors.forename: S
authors.initials: S
authors.lastname: Yiğit
authors.forename: E
authors.initials: E
authors.lastname: Elmali
authors.forename: E
authors.initials: E
authors.lastname: Malhatun
authors.forename: S
authors.initials: S
authors.lastname: Rota
authors.forename: N
authors.initials: N
authors.lastname: Kiliç
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy / Q000201:enzymology* / Q000503:physiopathology; D003924:Diabetes Mellitus, Type 2 / Q000201:enzymology; D005905:Glyburide / Q000494:pharmacology*; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D008297:Male; D018482:Muscle, Skeletal / Q000187:drug effects* / Q000201:enzymology; D051381:Rats; D013482:Superoxide Dismutase / Q000378:metabolism*
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D013482:Superoxide Dismutase; D005905:Glyburide