title: Sleep and melatonin in infants: a preliminary study.
abstract: Sleep-wake patterns of 20 normal, healthy infants (16 girls and four boys; age range: 26-37 weeks) were recorded for a period of 1 week with a miniature activity monitor. Urine samples were extracted from the infants' disposable diapers that were collected during a 60-hour period to determine the levels of 6-sulphatoxymelatonin (aMT6s, a melatonin metabolite) using a radioimmunoassay test. Infants with "mature" secretion patterns (i.e. with an adult-like circadian rhythm) had a significantly delayed sleep-wake cycle in comparison to those with "immature" patterns. The onset of their nocturnal-sleep episode was delayed by almost 1 hour (22.1 vs. 21.2 hours; p < 0.05). Higher secretion rates of aMT6s during the evening hours (6:00-10:00 p.m.) were associated with earlier onset of nocturnal sleep (r = 0.51; p < 0.05). A delayed peak of melatonin was associated with more fragmented sleep during the night (e.g. r = 0.49; p < 0.05; for lower sleep percent). These findings suggest that melatonin plays an important role in the evolution of the sleep-wake system.
authors.affiliation: Department of Psychology, Tel-Aviv University, Israel.
authors.forename: A
authors.initials: A
authors.lastname: Sadeh
mesh_terms: D002657:Child Development; D002940:Circadian Rhythm / Q000502:physiology*; D005260:Female; D006801:Humans; D007223:Infant; D018730:Infant Behavior / Q000502:physiology*; D008297:Male; D008550:Melatonin / Q000031:analogs & derivatives / Q000378:metabolism* / Q000652:urine; D012890:Sleep / Q000502:physiology*
chemical_list: D008550:Melatonin