title: The effects of chemotherapy on the long-term survivors of malignancy.
abstract: It is estimated that by the year 2000 one in a thousand 20-year-olds will be a survivor of childhood cancer. Increasingly, chemotherapy alone is being used because of concerns about the long-term effects of radiotherapy. However, chemotherapy may also have long-term effects particularly on growth and body composition, cardiac function and fertility. Other important late effects include renal and lung toxicity, hearing impairment, neuro-psychological sequalae and secondary leukaemias.
authors.affiliation: University Department of Paediatrics, Children's Hospital, Western Bank, Sheffield.
authors.forename: H A
authors.initials: HA
authors.lastname: Davies
authors.forename: J K
authors.initials: JK
authors.lastname: Wales
mesh_terms: D000293:Adolescent; D001823:Body Composition / Q000187:drug effects; D002648:Child; D002675:Child, Preschool; D005260:Female; D006128:Growth / Q000187:drug effects*; D006130:Growth Disorders / Q000139:chemically induced*; D006321:Heart / Q000187:drug effects; D006801:Humans; D007223:Infant; D008297:Male; D009369:Neoplasms / Q000188:drug therapy*; D010053:Ovary / Q000187:drug effects; D017741:Survivors; D013737:Testis / Q000187:drug effects