title: Reversible hearing impairment induced by lithium in the guinea pig.
abstract: Lithium salts remain one of the most widely used treatments for depressive illness. The mechanisms involved probably include reduction in free inositol. Visual perceptive disturbances can be a side effect of the treatment. We report here for the first time that chronic lithium treatment in the guinea pig induces a predominantly low frequency hearing loss and, in the longer term, loss of sensitivity is observed across the whole audiogram. The changes are reversed when treatment is arrested. The observations could be accounted for, at least partially, by a lithium-induced perturbation of the phosphoinositide cascade within the inner ear.
authors.affiliation: INSERM Laboratoire d'Audiologie Expérimentale, Bordeaux, France.
authors.forename: K C
authors.initials: KC
authors.lastname: Horner
authors.forename: Z W
authors.initials: ZW
authors.lastname: Huang
authors.forename: D
authors.initials: D
authors.lastname: Higuerie
authors.forename: Y
authors.initials: Y
authors.lastname: Cazals
mesh_terms: D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D001299:Audiometry; D006168:Guinea Pigs; D018072:Hair Cells, Auditory, Outer / Q000187:drug effects* / Q000378:metabolism; D034381:Hearing Loss / Q000139:chemically induced* / Q000378:metabolism; D007295:Inositol Phosphates / Q000378:metabolism*; D008094:Lithium / Q000633:toxicity*
chemical_list: D007295:Inositol Phosphates; D008094:Lithium