Transfer of autoimmune thyroiditis and resolution of palmoplantar pustular psoriasis following allogeneic bone marrow transplantation.
We report an unusual case of a patient who was cured of one autoimmune disease (palmoplantar pustular psoriasis (PPP)) but developed another autoimmune disease (autoimmune thyroiditis) after allogeneic BMT. A 40-year-old man suffering from AML with PPP underwent allogeneic BMT from his HLA-identical sister for the treatment of AML. The patient experienced complete clearance of the cutaneous PPP despite the cessation of immunosuppressive therapy for over 2 years. However, he developed hyperthyroidism with anti-thyroglobulin antibodies 5 months after BMT, although he had showed normal thyroid functions without anti-thyroglobulin antibodies before BMT. The donor had no history of thyroid diseases and showed normal thyroid functions but was positive for anti-thyroglobulin antibodies. Thus, even when the donor is in a subclinical state, autoimmune thyroiditis may be transferred from donors to recipients by BMT.
Kishimoto
Y
Y
First Department of Internal Medicine, Kansai Medical University, Moriguchi, Osaka, Japan.
Yamamoto
Y
Y
Ito
T
T
Matsumoto
N
N
Ichiyoshi
H
H
Katsurada
T
T
Date
M
M
Ohga
S
S
Kitajima
H
H
Ikehara
S
S
Fukuhara
S
S
D019264:Adoptive Transfer; D000328:Adult; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000150:complications / Q000628:therapy; D008297:Male; D011565:Psoriasis / Q000150:complications / Q000628:therapy*; D013967:Thyroiditis, Autoimmune / Q000209:etiology*; D014019:Tissue Donors; D014184:Transplantation, Homologous