title: The effect of dietary energy restriction on body weight gain and the development of noninsulin-dependent diabetes mellitus (NIDDM) in Psammomys obesus.
abstract: Food intake was restricted to 75% of ad libitum levels in 37 male Psammomys obesus (Israeli Sand Rats) from the ages of 4 (weaning) to 10 weeks. Energy restriction reduced the mean bodyweight at 10 weeks by 29% compared with 44 ad libitum fed controls. Hyperglycemia was prevented completely in the food-restricted group, and mean blood glucose concentrations were significantly reduced (3.8 +/- 0.2 vs. 5.5 +/- 0.4 mumol/L; p < 0.05) compared with control animals. Plasma insulin concentrations were also decreased significantly compared with ad libitum fed controls (105 +/- 13 vs. 241 +/- 29 mU/L; p < 0.05). Although energy restriction prevented hyperglycemia from developing in 10-week-old P. obesus, 19% of the food restricted animals still developed hyperinsulinemia. We concluded that hyperphagia between the ages of 4 to 10 weeks may be essential for the development of noninsulin-dependent diabetes mellitus in P. obesus, but that hyperinsulinemia may still occur in the absence of hyperphagia and hyperglycemia, suggesting a significant genetic influence on the development of hyperinsulinemia in this animal model.
authors.affiliation: School of Nutrition and Public Health, Deakin University, Geelong, Victoria, Australia.
authors.forename: K
authors.initials: K
authors.lastname: Walder
authors.forename: C R
authors.initials: CR
authors.lastname: Dascaliuc
authors.forename: P A
authors.initials: PA
authors.lastname: Lewandowski
authors.forename: A J
authors.initials: AJ
authors.lastname: Sanigorski
authors.forename: P
authors.initials: P
authors.lastname: Zimmet
authors.forename: G R
authors.initials: GR
authors.lastname: Collier
mesh_terms: D000818:Animals; D003924:Diabetes Mellitus, Type 2 / Q000209:etiology* / Q000235:genetics / Q000503:physiopathology; D004032:Diet; D004435:Eating; D002149:Energy Intake; D005260:Female; D005849:Gerbillinae; D006943:Hyperglycemia; D006963:Hyperphagia / Q000503:physiopathology; D007333:Insulin Resistance / Q000502:physiology*; D008297:Male; D015430:Weight Gain / Q000502:physiology*