title: Effects of discrimination learning on the rat striatal dopaminergic activity: a microdialysis study.
abstract: The prefrontal cortex (PFC) has anatomical and functional relationships with the striatum. In a previous study we showed that dopamine (DA) turnover in the PFC of rats is enhanced during the performance of a discrimination task. In the present study, we used an in vivo microdialysis method to examine whether DAergic activity in the striatum could also be altered by the discrimination task. The results showed a substantial and sustained suppression of DAergic activity during and after the discriminative behaviour. The fact that the discriminative performance induced opposite changes in DAergic activity in the striatum and the PFC is consistent with the results of biochemical studies, suggesting that the suppressed DA turnover in the striatum may be induced by the enhanced DAergic activity in the PFC during the discrimination task.
authors.affiliation: Department of Neuro-Psychiatry, Saitama Medical School, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Iwano
authors.forename: Y
authors.initials: Y
authors.lastname: Yamamuro
authors.forename: K
authors.initials: K
authors.lastname: Hori
authors.forename: T
authors.initials: T
authors.lastname: Yamauchi
authors.forename: M
authors.initials: M
authors.lastname: Nomura
mesh_terms: D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism; D000704:Analysis of Variance; D000818:Animals; D003342:Corpus Striatum / Q000502:physiology*; D004193:Discrimination Learning / Q000502:physiology*; D004298:Dopamine / Q000378:metabolism / Q000502:physiology*; D006719:Homovanillic Acid / Q000378:metabolism; D008297:Male; D017551:Microdialysis; D017397:Prefrontal Cortex / Q000502:physiology*; D051381:Rats; D011916:Rats, Inbred F344
chemical_list: D015102:3,4-Dihydroxyphenylacetic Acid; D004298:Dopamine; D006719:Homovanillic Acid