title: Quinolinic acid and lymphocyte subsets in the intrathecal compartment as biomarkers of SIV infection and simian AIDS.
abstract: Cerebrospinal fluid (CSF) samples were collected from monkeys infected with SIVmac251 (SIV) or HIV-1/SIVmac chimeric viruses (SHIV(HXBc2) and SHIV(89.6P)) to investigate quinolinic acid (QUIN) levels in the intrathecal compartment. CSF levels of QUIN were elevated in the SIV-infected monkeys, especially in animals with end-stage disease, and in those infected with pathogenic SHIV(89.6P), but not after infection with the nonpathogenic construct SHIV(HXBc2). QUIN elevations occurred in association with reduced CD4+ and increased CD8+ lymphocytes, cellular alterations that were more pronounced in CSF than in the blood. These findings support the view that the intrathecal compartment provides a unique window on viral infection, and are in keeping with the a priori prediction that QUIN increases primarily in response to more pathogenic viral strains.
authors.affiliation: Department of Psychology, University of Wisconsin-Madison, 53715, USA.
authors.forename: C L
authors.initials: CL
authors.lastname: Coe
authors.forename: T M
authors.initials: TM
authors.lastname: Reyes
authors.forename: C D
authors.initials: CD
authors.lastname: Pauza
authors.forename: J F
authors.initials: JF
authors.lastname: Reinhard
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000134:cerebrospinal fluid; D001812:Blood-Brain Barrier; D016516:CD4-CD8 Ratio; D016131:Lymphocyte Subsets; D008253:Macaca mulatta; D008297:Male; D017378:Quinolinic Acid / Q000134:cerebrospinal fluid*; D016097:Simian Acquired Immunodeficiency Syndrome / Q000134:cerebrospinal fluid* / Q000276:immunology / Q000821:virology; D015302:Simian Immunodeficiency Virus / Q000472:pathogenicity; D014774:Virulence
chemical_list: D015415:Biomarkers; D017378:Quinolinic Acid