The role of stromal cell heparan sulphate in regulating haemopoiesis.
Intimate contact between haemopoietic progenitor cells and elements of the bone marrow stroma is required for progenitor cell proliferation and differentiation. It is believed that the stroma provides particular niches for the development of haemopoietic cells of different lineages. Cytokines, stromal cell surface molecules and molecules of the stromal extracellular matrix all contribute to defining these microenvironmental niches. Data obtained using an in vitro model of haemopoiesis support the view that progenitor cell adhesion to stroma is mediated by multiple receptor-ligand interactions. The possibility of a tethering step, mediated by the engagement of stromal cell heparan sulphate with its ligands on the progenitor cells, preceding stable cell adhesion is discussed. The role of stromal cell heparan sulphate is likely to include cytokine presentation to progenitors as well as the tethering of progenitors to stroma. It is proposed that intracellular signals induced by progenitor cell adhesion to stroma act in association with cytokine induced signals to regulate progenitor cell proliferation and differentiation.
Coombe
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DR
TVW Telethon Institute for Child Health Research, West Perth, Western Australia.
D000273:Adipose Tissue / Q000502:physiology; D000328:Adult; D000818:Animals; D001853:Bone Marrow / Q000502:physiology*; D001854:Bone Marrow Cells; D002448:Cell Adhesion; D015815:Cell Adhesion Molecules / Q000502:physiology; D002454:Cell Differentiation; D019070:Cell Lineage; D002478:Cells, Cultured; D003238:Connective Tissue / Q000502:physiology; D005109:Extracellular Matrix / Q000502:physiology; D006410:Hematopoiesis / Q000502:physiology*; D016298:Hematopoietic Cell Growth Factors / Q000502:physiology; D006412:Hematopoietic Stem Cells / Q000166:cytology; D006497:Heparan Sulfate / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D011956:Receptors, Cell Surface / Q000502:physiology
D015815:Cell Adhesion Molecules; D016298:Hematopoietic Cell Growth Factors; D006497:Heparan Sulfate; D011956:Receptors, Cell Surface