title: Aortic root dilatation in Marfan's syndrome: a contribution from obstructive sleep apnea?
abstract: We report two cases of Marfan's syndrome with coexistent obstructive sleep apnea (OSA) in which treatment with nasal continuous positive airway pressure was associated with attenuation of aortic root dilatation, a serious complication of the syndrome. We speculate that coexistent OSA promotes progressive aortic dilatation in some patients with Marfan's syndrome.
authors.affiliation: Sleep Disorders Centre, Department of Respiratory Medicine, Royal Prince Alfred Hospital, Sydney, NSW, Australia.
authors.forename: P A
authors.initials: PA
authors.lastname: Cistulli
authors.forename: I
authors.initials: I
authors.lastname: Wilcox
authors.forename: R
authors.initials: R
authors.lastname: Jeremy
authors.forename: C E
authors.initials: CE
authors.lastname: Sullivan
mesh_terms: D000293:Adolescent; D000328:Adult; D001011:Aorta / Q000473:pathology*; D004108:Dilatation, Pathologic / Q000150:complications / Q000175:diagnosis / Q000628:therapy; D005260:Female; D006801:Humans; D008297:Male; D008382:Marfan Syndrome / Q000150:complications* / Q000628:therapy; D011175:Positive-Pressure Respiration; D012891:Sleep Apnea Syndromes / Q000150:complications* / Q000628:therapy