First-trimester repeated abortion is not associated with activated protein C resistance.
The present study was undertaken to investigate the possible association between activated protein C resistance and first-trimester repeated abortion. Fifty-five consecutive patients with unexplained first-trimester repeated abortion and 50 healthy control women having at least one child but no previous abortion were included. Activated protein C resistance was measured in all subjects and factor V Leiden genotype testing was performed in those individuals with phenotypic activated protein C resistance. One patient with first-trimester repeated abortion and one control subject had phenotypic activated protein C resistance. Genotype analysis confirmed that both subjects were heterozygous for factor V Leiden. Our results indicate that first-trimester repeated abortion is not associated with activated protein C resistance. Factor V Leiden screening in first-trimester repeated abortion is not warranted.
Balasch
J
J
Department of Obstetrics and Gynaecology, Faculty of Medicine-University of Barcelona, Hospital Clínic i Provincial, Spain.
Reverter
J C
JC
Fábregues
F
F
Tàssies
D
D
Rafel
M
M
Creus
M
M
Vanrell
J A
JA
D000026:Abortion, Habitual / Q000097:blood* / Q000235:genetics; D000328:Adult; D004789:Enzyme Activation; D005165:Factor V / Q000032:analysis / Q000235:genetics; D005260:Female; D005343:Fibrinolytic Agents / Q000032:analysis*; D005838:Genotype; D006579:Heterozygote; D006801:Humans; D009154:Mutation; D010641:Phenotype; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011486:Protein C / Q000032:analysis*
D005343:Fibrinolytic Agents; D011486:Protein C; C095381:factor V Leiden; D005165:Factor V