Suppression of ischemic edema in mice by manganese-hyaluronate conjugate.
Manganese-hyaluronate conjugate (Mn-HA) was synthesized from a diethylenetriaminepenta-acetic acid derivative of hyaluronic acid and manganese ion. The conjugate markedly scavenged super-oxide anion in vitro and exhibited much higher anti-inflammatory activity than superoxide dismutase in suppressing paw edema in mice when intravenously injected 30 min before the initiation of ischemia.
Sakurai
K
K
Toin Human Science and Technology Center, Department of Materials Science and Technology, Toin University of Yokohama, Japan.
Andoh
M
M
Yamada
M
M
Kodera
Y
Y
Nishimura
H
H
Hiroto
M
M
Matsushima
A
A
Aoyama
M
M
Yamamoto
H
H
Inada
Y
Y
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis / Q000494:pharmacology*; D002614:Chelating Agents / Q000737:chemistry; D004487:Edema / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control*; D004578:Electron Spin Resonance Spectroscopy; D016166:Free Radical Scavengers / Q000138:chemical synthesis / Q000494:pharmacology*; D006614:Hindlimb / Q000098:blood supply*; D006820:Hyaluronic Acid / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D007511:Ischemia / Q000150:complications* / Q000378:metabolism / Q000503:physiopathology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D004369:Pentetic Acid / Q000737:chemistry; D012039:Regional Blood Flow / Q000187:drug effects / Q000502:physiology; D013482:Superoxide Dismutase / Q000494:pharmacology
D000894:Anti-Inflammatory Agents, Non-Steroidal; D002614:Chelating Agents; D016166:Free Radical Scavengers; D004369:Pentetic Acid; D006820:Hyaluronic Acid; D013482:Superoxide Dismutase