A paradoxical effect of bronchodilators.
Lactic acidosis previously has been reported during treatment of asthma with beta-2 agonists. However, this metabolic disturbance never had any clinical consequence. We report a case of a patient with asthma in whom beta-2 agonist administration increased dyspnea by metabolic acidosis due to a sharp increase in lactate levels (hyperlactatemia) and led to inappropriate intensification of bronchodilator therapy.
Maury
E
E
Intensive Care Unit, Hôpital Saint Antoine, Paris, France.
Ioos
V
V
Lepecq
B
B
Guidet
B
B
Offenstadt
G
G
D000140:Acidosis, Lactic / Q000139:chemically induced*; D000208:Acute Disease; D000318:Adrenergic beta-Agonists / Q000009:adverse effects*; D000420:Albuterol / Q000009:adverse effects*; D001249:Asthma / Q000150:complications / Q000188:drug therapy; D001993:Bronchodilator Agents / Q000009:adverse effects*; D004417:Dyspnea / Q000139:chemically induced; D006801:Humans; D008297:Male; D008875:Middle Aged
D000318:Adrenergic beta-Agonists; D001993:Bronchodilator Agents; D000420:Albuterol