title: Historical cohort mortality study of a continuous filament fiberglass manufacturing plant. I. White men.
abstract: An historical cohort mortality study of a continuous filament fiberglass manufacturing plant was undertaken to determine whether an elevated lung cancer risk would be observed on a cohort basis. A nested case-control study of white male lung cancer deaths was incorporated into the study design. An interview survey to obtain information on sociodemographic factors, including smoking, and an historical environmental reconstruction to identify elements in the plant environment to which workers might be exposed were included in the study design. Respirable glass (Beta) fibers were produced only from 1963 to 1968. The lung cancer odds ratio (OR) among those workers exposed to respirable glass fibers is below unity, as are ORs for exposure to asbestos, refractory ceramic fibers, respirable silica (except for the lowest exposure level), total chrome and arsenic. There is a suggestion of an increase with exposure among smokers only for exposure to formaldehyde, although the OR for the highest level is based on only one case and is not likely to be meaningful. None of these plant exposures suggests an increase in lung cancer risk for this population. Although the lung cancer standardized mortality ratios are slightly elevated, results of the case-control investigation confirm that neither respirable glass fibers nor any of the substances investigated as part of the plant environment are associated with an increase in lung cancer risk for this population.
authors.affiliation: Department of Family Medicine, Georgetown University Medical Center, Washington, DC 20007, USA.
authors.forename: L
authors.initials: L
authors.lastname: Chiazze
authors.forename: D K
authors.initials: DK
authors.lastname: Watkins
authors.forename: C
authors.initials: C
authors.lastname: Fryar
mesh_terms: D016022:Case-Control Studies; D002423:Cause of Death; D002617:Chemical Industry; D015331:Cohort Studies; D003625:Data Collection; D005260:Female; D005898:Glass; D006801:Humans; D008175:Lung Neoplasms / Q000209:etiology / Q000401:mortality*; D008297:Male; D009784:Occupational Diseases / Q000209:etiology / Q000401:mortality* / Q000503:physiopathology; D016273:Occupational Exposure / Q000706:statistics & numerical data; D016017:Odds Ratio; D012307:Risk Factors; D015996:Survival Rate; D014481:United States / Q000453:epidemiology
chemical_list: C009753:fiberglass