Polysaccharopeptide from Coriolus versicolor has potential for use against human immunodeficiency virus type 1 infection.
Polysaccharopeptide (PSP) isolated from the edible mushroom Coriolus versicolor was tested for its potential as an anti-human immunodeficiency virus type 1 (HIV-1) compound in a series of in vitro assays. It demonstrated inhibition of the interaction between HIV-1 gp 120 and immobilized CD4 receptor (IC50 = 150 microg/ml), potent inhibition of recombinant HIV-1 reverse transcriptase (IC50 = 6.25 microg/ml), and inhibited a glycohydrolase enzyme associated with viral glycosylation. These properties, coupled with its high solubility in water, heat-stability and low cytotoxicity, make it a useful compound for further studies on its possible use as an anti-viral agent in vivo.
Collins
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Department of Biochemistry, The Chinese University of Hong Kong, Shatin, New Territories. racollins@cuhk.edu.hk
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D000276:Adjuvants, Immunologic / Q000494:pharmacology; D019380:Anti-HIV Agents / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000494:pharmacology; D001487:Basidiomycota; D015704:CD4 Antigens / Q000378:metabolism; D006026:Glycoside Hydrolases / Q000037:antagonists & inhibitors; D015699:HIV Envelope Protein gp120 / Q000378:metabolism; D015658:HIV Infections / Q000188:drug therapy*; D054303:HIV Reverse Transcriptase / Q000187:drug effects; D015497:HIV-1 / Q000187:drug effects* / Q000378:metabolism; D006801:Humans; D007124:Immunoenzyme Techniques; D011509:Proteoglycans / Q000494:pharmacology*; D018894:Reverse Transcriptase Inhibitors / Q000494:pharmacology
D000276:Adjuvants, Immunologic; D019380:Anti-HIV Agents; D000970:Antineoplastic Agents; D015704:CD4 Antigens; D015699:HIV Envelope Protein gp120; D011509:Proteoglycans; D018894:Reverse Transcriptase Inhibitors; C093216:polysaccharide peptide; D054303:HIV Reverse Transcriptase; D006026:Glycoside Hydrolases