Effects of interleukin-11 on carboplatin-induced thrombocytopenia in rats and in combination with stem cell factor.
The effects of interleukin-11 (IL-11) which stimulates megakaryopoiesis and thrombopoiesis and/or stem cell factor (SCF) which stimulates multiple lineage cells in the peripheral blood by an increase in marrow cellularity on hematopoietic suppression in carboplatin (CBDCA)-treated rats were determined. CBDCA was administered to rats at a dose of 35 mg/kg as a single intraperitoneal bolus on day 0. IL-11 (20 micrograms/day) was given subcutaneously for 10 days from day 5 after CBDCA treatment. IL-11 ameliorated the suppression of hematopoiesis in rats treated with CBDCA. Especially, the production of the platelets was stimulated by IL-11 more markedly than that of cells of other lineages. However, the combination of SCF and IL-11 intensified the CBDCA-induced suppression of hematopoiesis. These findings may be helpful in the design of future therapies to prevent or treat thrombocytopenia induced by chemotherapy.
Yonemura
Y
Y
Second Department of Internal Medicine, Kumamoto University School of Medicine, Japan.
Kawakita
M
M
Miyake
H
H
Miyazoe
T
T
Fujimoto
K
K
Takatsuki
K
K
D000818:Animals; D000970:Antineoplastic Agents / Q000633:toxicity*; D016190:Carboplatin / Q000633:toxicity*; D006410:Hematopoiesis / Q000187:drug effects; D017370:Interleukin-11 / Q000494:pharmacology* / Q000633:toxicity; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D011994:Recombinant Proteins / Q000494:pharmacology / Q000633:toxicity; D019089:Stem Cell Factor / Q000494:pharmacology* / Q000633:toxicity; D013921:Thrombocytopenia / Q000097:blood / Q000139:chemically induced* / Q000517:prevention & control
D000970:Antineoplastic Agents; D017370:Interleukin-11; D011994:Recombinant Proteins; D019089:Stem Cell Factor; D016190:Carboplatin