PF1092A, B and C, new nonsteroidal progesterone receptor ligands produced by Penicillium oblatum. II. Physico-chemical properties and structure elucidation.
The structures of PF1092A (1), B (2) and C (3), new nonsteroidal progesterone receptor ligands produced by Penicillium oblatum, were elucidated by spectroscopic analyses. These compounds possess an eremophilane-type sesquiterpene carbon skeleton and differ only in that 1 and 2 are different monoacetates of 3. The absolute configurations of 1-3 were determined by single crystal X-ray diffraction analysis of the 4-bromobenzoyl ester of PF1092A and by measuring the optical rotations of the acetylation products of these compounds.
Tabata
Y
Y
Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd., Yokohama, Japan.
Hatsu
M
M
Kurata
Y
Y
Miyajima
K
K
Tani
M
M
Sasaki
T
T
Kodama
Y
Y
Tsuruoka
T
T
Omoto
S
S
D005663:Furans / Q000737:chemistry* / Q000494:pharmacology*; D015394:Molecular Structure; D009284:Naphthols / Q000737:chemistry* / Q000494:pharmacology*; D012717:Sesquiterpenes / Q000737:chemistry*
D005663:Furans; D009284:Naphthols; C106748:PF 1092A; C106749:PF 1092B; C106750:PF 1092C; D012717:Sesquiterpenes