title: 3-Epi-aplykurodinone B, a new degraded sterol from Aplysia fasciata.
abstract: The anaspidean mollusk Aplysia fasciata from Río San Pedro (Cádiz, Spain) contains the known degraded sterols aplykurodinone B (2) and aplykurodin B (4) together with the new 3-epi-aplykurodinone B (5). The structure of 5 was elucidated by interpretation of spectral data, and its relative stereochemistry was established using NOEDS experiments. The new compound 5 exhibited cytotoxicity against four tumor cell lines.
authors.affiliation: Departamento de Química Orgánica, Facultad de Ciencias del Mar, Universidad de Cádiz, Spain.
authors.forename: M J
authors.initials: MJ
authors.lastname: Ortega
authors.forename: E
authors.initials: E
authors.lastname: Zubía
authors.forename: J
authors.initials: J
authors.lastname: Salvá
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000302:isolation & purification* / Q000494:pharmacology; D001048:Aplysia / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007189:Indans / Q000302:isolation & purification* / Q000494:pharmacology; D007783:Lactones / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D013055:Spectrophotometry, Infrared; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D007189:Indans; D007783:Lactones; C077373:aplykurodinone B