[The limitation of acute hypotension and hyperactivation of the vascular endothelium in rats with an experimental myocardial infarct by using preliminary adaptation to physical load].
Adaptation to swimming exercise was shown to increase the endothelium-dependent relaxation of the rat aorta, leaving the BP unaffected. In experimental myocardial infarction, the adaptation limited the BP fall and completely prevented an excessive suppression of norepinephrine-induced contractions of the aorta. An adaptation to exercise seems to be an efficient protective factor in pathological conditions involving the NO overproduction and endothelial hyperactivation.
Manukhina
E B
EB
Lapshin
A V
AV
Meerson
F Z
FZ
D000208:Acute Disease; D000222:Adaptation, Physiological; D000818:Animals; D001011:Aorta / Q000503:physiopathology; D001794:Blood Pressure / Q000502:physiology; D004195:Disease Models, Animal; D004730:Endothelium, Vascular / Q000503:physiopathology*; D007022:Hypotension / Q000503:physiopathology / Q000517:prevention & control*; D008297:Male; D009203:Myocardial Infarction / Q000150:complications / Q000503:physiopathology*; D005082:Physical Exertion / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D013550:Swimming / Q000502:physiology