NMDA receptor-dependent and -independent long-term depression in the CA1 region of the adult rat hippocampus in vitro.
We have investigated different stimulus parameters in an attempt to induce long-term depression (LTD) in the CA1 region of adult rat hippocampus in vitro. Whereas 900 stimuli delivered at 1 Hz failed to induce LTD, 900 stimuli when delivered as 450 pairs (50 msec inter-stimulus interval) at 1 Hz induced significant and stable N-methyl-D-aspartate (NMDA) receptor-dependent LTD. However, 900 paired stimuli at 1 Hz induced LTD which was only partly blocked by the NMDA receptor antagonist, D-2-amino-5-phosphonopentanoate (AP5).
Kemp
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Department of Anatomy, School of Medical Sciences, University of Bristol, U.K.
Bashir
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ZI
D015763:2-Amino-5-phosphonovalerate / Q000494:pharmacology*; D000818:Animals; D004558:Electric Stimulation; D005260:Female; D006624:Hippocampus / Q000187:drug effects*; D066298:In Vitro Techniques; D008564:Membrane Potentials / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D016194:Receptors, N-Methyl-D-Aspartate / Q000187:drug effects*
D016194:Receptors, N-Methyl-D-Aspartate; D015763:2-Amino-5-phosphonovalerate