title: PF1092A, B and C, new nonsteroidal progesterone receptor ligands produced by Penicillium oblatum. I. Taxonomy of producing strain, fermentation, isolation and biological activities.
abstract: Three new nonsteroidal progesterone receptor ligands, PF1092A, B and C, have been isolated from Penicillium oblatum. They were purified from the solid cultures of rice media using ethyl acetate extraction, silica gel and Sephadex LH-20 column chromatographies, and crystallization. All three ligands competitively inhibited [3H]-progesterone binding to porcine uteri cytosol preparations with IC50 of 3.0 x 10 nM (PF1092A), 2.2 x 10(2) nM (PF1092B) and 2.2 x 10(3) nM (PF1092C).
authors.affiliation: Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd., Yokohama, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Tabata
authors.forename: N
authors.initials: N
authors.lastname: Miike
authors.forename: M
authors.initials: M
authors.lastname: Hatsu
authors.forename: Y
authors.initials: Y
authors.lastname: Kurata
authors.forename: T
authors.initials: T
authors.lastname: Yaguchi
authors.forename: A
authors.initials: A
authors.lastname: Someya
authors.forename: S
authors.initials: S
authors.lastname: Miyadoh
authors.forename: S
authors.initials: S
authors.lastname: Hoshiko
authors.forename: T
authors.initials: T
authors.lastname: Tsuruoka
authors.forename: S
authors.initials: S
authors.lastname: Omoto
mesh_terms: D000818:Animals; D001667:Binding, Competitive; D003600:Cytosol / Q000378:metabolism; D005285:Fermentation; D005663:Furans / Q000302:isolation & purification* / Q000494:pharmacology; D008024:Ligands; D009284:Naphthols / Q000302:isolation & purification* / Q000494:pharmacology; D010407:Penicillium; D011374:Progesterone / Q000378:metabolism; D011980:Receptors, Progesterone / Q000187:drug effects*; D012717:Sesquiterpenes / Q000302:isolation & purification* / Q000494:pharmacology; D013552:Swine
chemical_list: D005663:Furans; D008024:Ligands; D009284:Naphthols; C106748:PF 1092A; C106749:PF 1092B; C106750:PF 1092C; D011980:Receptors, Progesterone; D012717:Sesquiterpenes; D011374:Progesterone