[The condition of PCBs and PCDFs in the blood of Yusho patients 20 years after the onset].
Blood samples of Yusho and control persons were analyzed for individual congeners of PCDDs, PCDFs, and PCBs by high resolution GC/MS. Concentrations of 2,3,4,7,8-penta-CDF, 1,2,3,4,7,8-hexa-CDF and 2,3,3',4,4',5-hexa-CB in Yusho blood were up to 56 times higher than the corresponding concentrations in the control blood. These high concentrations have persisted for 23 years after the incident. Concentrations of 3,3',4,4',5-penta-CB and 2,3',4,4',5-penta-CB in some Yusho blood were lower than the control blood. In Yusho blood, 2,3,4,7,8-penta-CDF contributed the highest toxicity (TEQ 77-248 ppt in lipid) among the congeners determined and toxic contribution of PCDFs was very large (41-77%) in the chlorinated pollutants. Thirty PCB congeners were identified in the blood of Yusho patients in 1996 by GC/MS. The average total PCB concentration in Yusho blood were 4.9 times higher than that of the controls. Characteristic PCB congeners in Yusho patients were 2,2',3,4,4',5-hexa-CB, 2,3,3',4,4',5-hexa-CB and 2,3,3',4,4',5'-hexa-CB and their concentration ratios to the controls were 8-19.
Masuda
Y
Y
Daiichi College of Pharmaceutical Sciences, Fukuoka.
Kuroki
H
H
Haraguchi
K
K
Schecter
A
A
Päpke
O
O
D000328:Adult; D001572:Benzofurans / Q000032:analysis*; D005506:Food Contamination; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D008297:Male; D012275:Oryza / Q000506:poisoning*; D010938:Plant Oils / Q000506:poisoning*; D011041:Poisoning / Q000097:blood; D011078:Polychlorinated Biphenyls / Q000097:blood* / Q000506:poisoning*; D011108:Polymers / Q000032:analysis*; D013997:Time Factors
D001572:Benzofurans; D010938:Plant Oils; D011108:Polymers; C016068:polychlorodibenzofuran; D011078:Polychlorinated Biphenyls