Protective effect of Rhinax, a herbal formulation, against CCl4-induced liver injury and survival in rats.
Rhinax, a herbal formulation, was investigated for its protective activity against CCl4-induced liver injury and survival in rats. Oral administration of Rhinax at a dose of 80 mg/kg significantly reduces the hepatotoxic effects of CCl4. It also significantly improves the survival of rats at a dose of 160 mg/kg. On the basis of these observations, we conclude that Rhinax possesses anti-hepatotoxic activity and that the observed activity may be due to the increased activity of cytochrome P450, thereby exerting an inhibitory effect on reductive pathways of CCl4.
Dhuley
J N
JN
Pharmacology and Toxicology Division, Hindustan Antibiotics Limited, Pune, India.
Naik
S R
SR
D000284:Administration, Oral; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D002251:Carbon Tetrachloride / Q000008:administration & dosage / Q000633:toxicity*; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004195:Disease Models, Animal; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D008107:Liver Diseases / Q000188:drug therapy / Q000401:mortality; D008297:Male; D008515:Medicine, Ayurvedic; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology / Q000473:pathology; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D010946:Plants, Medicinal / Q000737:chemistry; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar
D010936:Plant Extracts; D003577:Cytochrome P-450 Enzyme System; D002251:Carbon Tetrachloride; D001219:Aspartate Aminotransferases