H-2 genes and resistance to infection with Heligmosomoides polygyrus in selectively bred mice.
Two lines of mice bred selectively for high resistance (RH) and susceptibility (SL) to reinfection with Heligmosomoides polygyrus demonstrated disparate levels of resistance to infection but did not differ in the frequency of H-2 antigens when assayed with antisera against antigens of 5 inbred H-2 haplotypes. The selected RH and SL mice were crossbred with, and backcrossed to, the inbred CBA mice. F1 mice from crosses between RH and CBA were as resistant to reinfection with H. polygyrus as their RH parents. F1 mice from crosses between SL and CBA were more resistant than either of their parents. BC1 mice were either positive or negative for H-2 antigens from RH and SL mice. BC1 mice that were positive for RH H-2 antigens were more resistant to infection than their negative littermates, but they were significantly more susceptible to infection with H. polygyrus than their F1 parents. These results demonstrated that genes within and mapped outside H-2 complex control the level of resistance to H. polygyrus in the selected mice and suggested that selective breeding of mice for resistance fixed the relevant genes in and outside the H-2 complex.
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Department of Parasitology, University of Queensland, Brisbane, Australia. zhong@parasit.lan.mcgill.ca
Dobson
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D000818:Animals; D003433:Crosses, Genetic; D005260:Female; D005805:Genes, MHC Class I; D006183:H-2 Antigens / Q000235:genetics*; D006239:Haplotypes; D007113:Immunity, Innate / Q000235:genetics; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009351:Nematospiroides dubius; D017206:Strongylida Infections / Q000235:genetics / Q000276:immunology*
D006183:H-2 Antigens