Clinical features of childhood-onset schizophrenia with obsessive-compulsive symptoms during the prodromal phase.
Thirty-nine patients with schizophrenia, diagnosed according to DSM-III-R, who were under 15 years of age, were studied in two groups; 16 subjects with obsessive-compulsive symptoms during the prodromal phase, and 23 with no obsessive-compulsive disorders. The group with obsessive-compulsive symptoms during the prodromal phase was characterized by a higher ratio of males, higher incidences of perinatal and brain computed tomography (CT) abnormalities, fewer hereditary factors, longer duration of the prodromal phase, and a higher incidence of insidious onset and negative symptoms compared with the group without such prodromal symptoms. Schizophrenic patients with obsessive-compulsive symptoms during the prodromal phase were clinically distinct from those without, which suggests the possibility of subtype categorization.
Iida
J
J
Department of Psychiatry, Nara Medical University, Japan.
Iwasaka
H
H
Hirao
F
F
Hashino
K
K
Matsumura
K
K
Tahara
K
K
Aoyama
F
F
Sakiyama
S
S
Tsujimoto
H
H
Kawabata
Y
Y
Ikawa
G
G
D000293:Adolescent; D017668:Age of Onset; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D009771:Obsessive-Compulsive Disorder / Q000235:genetics / Q000523:psychology*; D010551:Personality; D011569:Psychiatric Status Rating Scales; D012561:Schizophrenia, Childhood / Q000235:genetics / Q000523:psychology*; D012565:Schizophrenic Psychology; D012744:Sex Ratio; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome