title: Laminin-binding proteins in EJ-ras-transformed fibroblasts.
abstract: Malignant transformation is accompanied by changes in cell-matrix interactions. Upon transfection with EJ-ras oncogene, transformed fibroblasts acquired a migratory phenotype towards laminin-1. The increase in integrin expression was responsible for the migratory activity of transformed fibroblasts. In addtion alpha 6 beta 1 integrins, both galectin-3 and an unidentified laminin-binding polypeptide had their expression pattern altered upon transformation. Here, we review these two classes of laminin-binding proteins and their possible roles in cell-laminin interactions.
authors.affiliation: Ludwig Institute for Cancer Research, São Paulo, Brasil. rchammas@ucsd.edu
authors.forename: R
authors.initials: R
authors.lastname: Chammas
authors.forename: M G
authors.initials: MG
authors.lastname: Jasiulionis
authors.forename: A M
authors.initials: AM
authors.lastname: Ventura
authors.forename: L R
authors.initials: LR
authors.lastname: Travassos
authors.forename: R R
authors.initials: RR
authors.lastname: Brentani
mesh_terms: D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D005347:Fibroblasts / Q000276:immunology*; D011905:Genes, ras / Q000235:genetics*; D006801:Humans; D007797:Laminin / Q000276:immunology*; D037102:Lectins / Q000276:immunology*; D015674:Mammary Neoplasms, Animal / Q000276:immunology*; D009857:Oncogenes / Q000276:immunology
chemical_list: D007797:Laminin; D037102:Lectins