title: Etiology of (CAG)n triplet repeat neurodegenerative diseases such as Huntington's disease is connected to stimulation of glutamate receptors.
abstract: Chronic neurodegenerative diseases with expanded, genetically unstable (CAG)n triplet repeats include Huntington's disease. It is hypothesized that pathology results from excessive stimulation of glutamate receptors by glutamine.
authors.forename: K M
authors.initials: KM
authors.lastname: Fischer
mesh_terms: D015551:Autoimmunity; D002561:Cerebrovascular Disorders / Q000378:metabolism; D004827:Epilepsy / Q000378:metabolism; D018698:Glutamic Acid / Q000378:metabolism; D006801:Humans; D006816:Huntington Disease / Q000209:etiology* / Q000235:genetics* / Q000378:metabolism; D018598:Minisatellite Repeats; D008954:Models, Biological; D009410:Nerve Degeneration / Q000235:genetics / Q000502:physiology; D017470:Receptors, Glutamate / Q000378:metabolism*; D018911:Trinucleotide Repeats
chemical_list: D017470:Receptors, Glutamate; D018698:Glutamic Acid