Intranigral grafts of fetal ventral mesencephalic tissue in adult 6-hydroxydopamine-lesioned rats can induce behavioral recovery.
Intrastriatal grafts of fetal ventral mesencephalon in rats with unilateral 6-hydroxydopamine lesions can reduce and even reverse rotational behavior in response to direct and indirect dopamine agonists. These grafts can ameliorate deficits on simple spontaneous behaviors, but do not improve complex behaviors that require the skilled integration of the use of both paws. We report here that rats with grafts into the DA-depleted substantia nigra, that receive cyclosporine A, can experience recovery on spontaneous behaviors that mimic those observed in Parkinson's disease. Specific cyclosporine A treatment conditions can differentially affect whether intranigral grafts normalize paw use during initiation or termination of a movement sequence. These findings may have important implications for the treatment of Parkinson's disease.
Johnston
R E
RE
University of Michigan Department of Psychology, Ann Arbor, 48109-1109, USA.
Becker
J B
JB
D000367:Age Factors; D000818:Animals; D001522:Behavior, Animal / Q000502:physiology*; D016380:Brain Tissue Transplantation; D003624:Darkness; D005260:Female; D016332:Fetal Tissue Transplantation; D006085:Graft Survival / Q000502:physiology; D008029:Lighting; D008636:Mesencephalon / Q000637:transplantation*; D009068:Movement / Q000502:physiology; D009474:Neurons / Q000201:enzymology; D016627:Oxidopamine; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D012399:Rotation; D013378:Substantia Nigra / Q000473:pathology / Q000601:surgery; D013565:Sympatholytics; D014446:Tyrosine 3-Monooxygenase / Q000032:analysis; D014743:Videotape Recording
D013565:Sympatholytics; D016627:Oxidopamine; D014446:Tyrosine 3-Monooxygenase