title: Psychosocial factors and the long-term course of major depression.
abstract: Fifty-nine subjects participated in a telephone follow-up interview 6 years after being hospitalized with a severe major depressive episode and 5 years after completing a 12 month follow-up study. Patient information was used to provide a rating of symptom-free (n = 19), episodic (n = 30), or chronic (n = 10) that described each patient's long-term course of illness. Few variables from the acute stage were related to long-term course of illness; however, early patterns of global and family functioning, number of life events, and rapid reduction in depressive symptomatology were found to be of prognostic significance. For patients whose depression is severe enough to warrant hospitalization, the pattern of functioning in the first few months after discharge from hospital is a strong indicator of the future long-term course.
authors.affiliation: Mood Disorders Program, Rhode Island Hospital, Providence 02903, USA.
authors.forename: G I
authors.initials: GI
authors.lastname: Keitner
authors.forename: C E
authors.initials: CE
authors.lastname: Ryan
authors.forename: I W
authors.initials: IW
authors.lastname: Miller
authors.forename: C
authors.initials: C
authors.lastname: Zlotnick
mesh_terms: D000328:Adult; D003866:Depressive Disorder / Q000175:diagnosis / Q000523:psychology*; D005190:Family / Q000523:psychology; D005192:Family Health; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales
chemical_list: D006854:Hydrocortisone