title: Inhibition of human leukocyte proteinase 3 by a novel recombinant serine proteinase inhibitor (LEX032).
abstract: The interaction of a bioengineered serpin (LEX032) with human leukocyte proteinase 3 (PR 3) has been investigated. LEX032 was found to be a time-dependent inhibitor of PR 3, forming a highly-stable enzyme-inhibitor complex (Ki 12 nM).
authors.affiliation: Department of Chemistry, Wichita State University, Kansas 67260, USA.
authors.forename: W C
authors.initials: WC
authors.lastname: Groutas
authors.forename: S
authors.initials: S
authors.lastname: Ruan
authors.forename: R
authors.initials: R
authors.lastname: Kuang
authors.forename: J B
authors.initials: JB
authors.lastname: Hook
authors.forename: H
authors.initials: H
authors.lastname: Sands
mesh_terms: D000595:Amino Acid Sequence; D001665:Binding Sites / Q000235:genetics; D006801:Humans; D066298:In Vitro Techniques; D007700:Kinetics; D007962:Leukocytes / Q000201:enzymology*; D053146:Myeloblastin; D011994:Recombinant Proteins / Q000235:genetics / Q000494:pharmacology; D012697:Serine Endopeptidases / Q000378:metabolism*; D015842:Serine Proteinase Inhibitors / Q000235:genetics / Q000494:pharmacology*; D015843:Serpins / Q000235:genetics / Q000494:pharmacology*
chemical_list: C095800:LEX 032; D011994:Recombinant Proteins; D015842:Serine Proteinase Inhibitors; D015843:Serpins; D012697:Serine Endopeptidases; D053146:Myeloblastin