title: Transfer of autoimmune thyroiditis and resolution of palmoplantar pustular psoriasis following allogeneic bone marrow transplantation.
abstract: We report an unusual case of a patient who was cured of one autoimmune disease (palmoplantar pustular psoriasis (PPP)) but developed another autoimmune disease (autoimmune thyroiditis) after allogeneic BMT. A 40-year-old man suffering from AML with PPP underwent allogeneic BMT from his HLA-identical sister for the treatment of AML. The patient experienced complete clearance of the cutaneous PPP despite the cessation of immunosuppressive therapy for over 2 years. However, he developed hyperthyroidism with anti-thyroglobulin antibodies 5 months after BMT, although he had showed normal thyroid functions without anti-thyroglobulin antibodies before BMT. The donor had no history of thyroid diseases and showed normal thyroid functions but was positive for anti-thyroglobulin antibodies. Thus, even when the donor is in a subclinical state, autoimmune thyroiditis may be transferred from donors to recipients by BMT.
authors.affiliation: First Department of Internal Medicine, Kansai Medical University, Moriguchi, Osaka, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Kishimoto
authors.forename: Y
authors.initials: Y
authors.lastname: Yamamoto
authors.forename: T
authors.initials: T
authors.lastname: Ito
authors.forename: N
authors.initials: N
authors.lastname: Matsumoto
authors.forename: H
authors.initials: H
authors.lastname: Ichiyoshi
authors.forename: T
authors.initials: T
authors.lastname: Katsurada
authors.forename: M
authors.initials: M
authors.lastname: Date
authors.forename: S
authors.initials: S
authors.lastname: Ohga
authors.forename: H
authors.initials: H
authors.lastname: Kitajima
authors.forename: S
authors.initials: S
authors.lastname: Ikehara
authors.forename: S
authors.initials: S
authors.lastname: Fukuhara
mesh_terms: D019264:Adoptive Transfer; D000328:Adult; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000150:complications / Q000628:therapy; D008297:Male; D011565:Psoriasis / Q000150:complications / Q000628:therapy*; D013967:Thyroiditis, Autoimmune / Q000209:etiology*; D014019:Tissue Donors; D014184:Transplantation, Homologous