title: [Value of PSA and (pre- postoperative) Gleason in predicting the potential lymphatic involvement in patients with prostatic cancer].
abstract: OBJECTIVE
  To determine the possibility of selecting patients at risk for lymph node involvement prior to radical prostatectomy utilizing PSA concentration and/or the Gleason score.
  
  
  METHODS
  We reviewed the records of 52 patients with tumor stage T1 to T3, who had undergone lymphadenectomy; of these, 50 patients underwent radical prostatectomy. The predictive values for PSA and the Gleason score and their utility in predicting risk of lymph node involvement were analyzed.
  
  
  RESULTS
  Of the 52 patients, 10 (19%) had lymph node involvement. Nine of 26 patients (35%) with PSA > 20 and 9 of 21 patients (42%) with a Gleason score > 7 had lymph node involvement. No patient with PSA < 15 or Gleason score < 5 and none of the 24 patients (57%) with PSA < 20 and Gleason score < 7 had lymph node involvement. The preoperative biopsy was understaged in 21 patients (41%); of these, 16% had a Gleason score of 5-6. Two of these patients with PSA > 20 micrograms/ml had lymph node involvement.
  
  
  CONCLUSIONS
  PSA concentration and the Gleason score are useful in predicting the risk of lymph node involvement. Patients with PSA < 20 and a Gleason score of < 7 can be considered to be at no risk and staging lymphadenectomy could be unnecessary. Although the preoperative Gleason score appears to have a predictive value, the possibility of understaging should be taken into account. In this regard PSA can be useful in identifying those patients at risk.
authors.affiliation: Servicio de Urología y Anatomía Patológica, Hospital Juan Canalejo, La Coruña, España.
authors.forename: F
authors.initials: F
authors.lastname: Gómez Veiga
authors.forename: J
authors.initials: J
authors.lastname: Díaz Bermúdez
authors.forename: L
authors.initials: L
authors.lastname: Alvarez Castelo
authors.forename: M J
authors.initials: MJ
authors.lastname: Lorenzo Patiño
authors.forename: J
authors.initials: J
authors.lastname: Rodríguez Rivera
authors.forename: V
authors.initials: V
authors.lastname: Chantada Abal
authors.forename: E
authors.initials: E
authors.lastname: Vázquez Martul
authors.forename: M
authors.initials: M
authors.lastname: González Martín
mesh_terms: D000368:Aged; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D018579:Patient Selection; D011182:Postoperative Care; D011237:Predictive Value of Tests; D011300:Preoperative Care; D017430:Prostate-Specific Antigen / Q000097:blood*; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000097:blood* / Q000473:pathology* / Q000601:surgery
chemical_list: D017430:Prostate-Specific Antigen