Identification of the ahp operon of Salmonella typhimurium as a macrophage-induced locus.
Previously, we tagged a macrophage-induced Salmonella typhimurium locus with Mudlux (K. P. Francis and M. P. Gallagher, Infect. Immun. 61:640-649, 1993). The insertion lies within the OxyR-regulated ahpC locus and conveys alkyl peroxide sensitivity. Plasmid-encoded ahp reverses sensitivity but reduces luminescence. This suggests that OxyR is titrated by the multicopy ahp promoter.
Francis
K P
KP
Division of Biology, University of Edinburgh, Scotland.
Taylor
P D
PD
Inchley
C J
CJ
Gallagher
M P
MP
D002874:Chromosome Mapping; D004268:DNA-Binding Proteins; D006861:Hydrogen Peroxide / Q000494:pharmacology; D008264:Macrophages / Q000502:physiology*; D009876:Operon; D010088:Oxidoreductases / Q000235:genetics*; D010544:Peroxidases; D054464:Peroxiredoxins; D012097:Repressor Proteins / Q000235:genetics; D012486:Salmonella typhimurium / Q000235:genetics*; D014157:Transcription Factors / Q000235:genetics
D004268:DNA-Binding Proteins; D012097:Repressor Proteins; D014157:Transcription Factors; D006861:Hydrogen Peroxide; D010088:Oxidoreductases; D010544:Peroxidases; D054464:Peroxiredoxins