Adverse drug reaction to rifampin: a case with long lasting antiplatelet antibodies.
Rifampin is a drug able to induce adverse reactions involving both the kidney and the hematological system. We observed a case, throughly studied and we deemed worth-while to report it, for some important features that were evident. Transient hemolytic anemia, recoverable acute renal failure, persistent increased titer of anti-platelet antibody lasting also after 3 weeks from the withdrawal of the drug and in spite of corticosteroid therapy, could be explained by the immune mechanisms that are, therefore, postulated.
Tricerri
A
A
Istituto di Medicina Interna e Geriatria, Universitä Cattolica del Sacro Cuore, Roma, Italy.
Vangeli
M
M
Addario
C
C
Guidi
L
L
Bartoloni
C
C
Magalini
S
S
Gentiloni Silveri
N
N
D000368:Aged; D000743:Anemia, Hemolytic / Q000139:chemically induced; D000904:Antibiotics, Antitubercular / Q000009:adverse effects*; D001323:Autoantibodies / Q000097:blood*; D001792:Blood Platelets / Q000276:immunology*; D006801:Humans; D008297:Male; D012293:Rifampin / Q000009:adverse effects*; D013921:Thrombocytopenia / Q000139:chemically induced
D000904:Antibiotics, Antitubercular; D001323:Autoantibodies; D012293:Rifampin