title: Antiviral activity of galangin isolated from the aerial parts of Helichrysum aureonitens.
abstract: The in vitro antiviral activity of galangin (3,5,7-trihydroxyflavone), the major antimicrobial compound isolated from the shoots of Helichrysum aureonitens, was investigated against herpes simplex virus type 1 (HSV-1), coxsackie B virus type 1 (Cox B1), adenovirus type 31 (Ad31) and reovirus. At concentrations ranging from 12-47 micrograms/ml galangin showed significant antiviral activity against HSV-1 and CoxB1, limited activity against reovirus, and no antiviral activity against Ad31.
authors.affiliation: Department of Botany, University of Pretoria, South Africa. Marion@scientia.up.ac.za
authors.forename: J J
authors.initials: JJ
authors.lastname: Meyer
authors.forename: A J
authors.initials: AJ
authors.lastname: Afolayan
authors.forename: M B
authors.initials: MB
authors.lastname: Taylor
authors.forename: D
authors.initials: D
authors.lastname: Erasmus
mesh_terms: D000260:Adenoviruses, Human / Q000187:drug effects*; D000818:Animals; D000998:Antiviral Agents / Q000302:isolation & purification / Q000494:pharmacology*; D006528:Carcinoma, Hepatocellular / Q000473:pathology; D002478:Cells, Cultured; D029822:Enterovirus B, Human / Q000187:drug effects*; D005419:Flavonoids / Q000302:isolation & purification / Q000494:pharmacology*; D000882:Haplorhini; D018259:Herpesvirus 1, Human / Q000187:drug effects*; D006801:Humans; D007668:Kidney / Q000166:cytology; D008113:Liver Neoplasms / Q000473:pathology; D009153:Mutagens / Q000302:isolation & purification; D010936:Plant Extracts / Q000494:pharmacology*; D018520:Plant Shoots / Q000737:chemistry / Q000378:metabolism; D010946:Plants, Medicinal / Q000737:chemistry; D012087:Reoviridae / Q000187:drug effects*; D013019:South Africa; D014407:Tumor Cells, Cultured
chemical_list: D000998:Antiviral Agents; D005419:Flavonoids; D009153:Mutagens; D010936:Plant Extracts; C037032:galangin