Stimulating effect of ileal pancreaticobiliary secretion on ileal apolipoprotein A-IV mRNA expression in fasted rats.
The effect of pancreaticobiliary secretion on the intestinal expression of the apo A-IV gene was examined in fasted rats. Pancreaticobiliary diversion, but not biliary diversion alone, into the ileum increased the ileal apo A-IV mRNA expression by 24 h post-operation. Jejunal apo A-IV mRNA was reduced by biliary exclusion. The data suggest that the biliary constituent plays an important role in the apo A-IV gene expression in the entire length of the small intestine, and that up-regulation of the apo A-IV gene requires exocrine pancreatic in addition to biliary secretion.
Sonoyama
K
K
Department of Bioscience and Chemistry, Faculty of Agriculture, Hokkaido University, Sapporo, Japan.
Fujiwara
R
R
Aoyama
Y
Y
D000818:Animals; D001054:Apolipoproteins A / Q000235:genetics*; D001659:Biliary Tract / Q000378:metabolism*; D015904:Biliopancreatic Diversion; D005215:Fasting / Q000502:physiology*; D007082:Ileum / Q000378:metabolism / Q000502:physiology*; D008297:Male; D010179:Pancreas / Q000378:metabolism*; D012333:RNA, Messenger / Q000096:biosynthesis*; D051381:Rats; D017208:Rats, Wistar; D013268:Stimulation, Chemical; D015854:Up-Regulation
D001054:Apolipoproteins A; D012333:RNA, Messenger; C022205:apolipoprotein A-IV