title: [Reproducibility of spasm in patients with long-term remission of vasospastic angina by medical treatment].
abstract: The reproducibility of coronary vasospasm was assessed in nine patients with complete remission of vasospastic angina by medical treatment by reexamination at intervals of mean [+/-SD] 5.7 +/- 0.9 years. Twenty-one segments were defined as spastic, demonstrating more than 90% narrowing after acetylcholine injection at the initial angiography. The degree of spasticity, type of spasm (diffuse or focal) and coronary artery diameter in these segments at the initial and follow-up studies were compared. Of the 21 segments, 17 (81%) still had some spasticity (> 25%) at the follow-up study and 8 (38%) of these 17 showed spasticity with greater than 90% narrowing. On the other hand, spasm was not reprovoked in 4 (19%) segments. Luminal diameter of the spastic segments decreased significantly at the follow-up study (2.52 +/- 0.83 vs 2.26 +/- 0.62 mm, p = 0.01), but percentage stenosis was not different between the initial and follow-up studies (9.1 +/- 7.2 vs 10.3 +/- 8.0%, NS). The reproducibility of the type of spasm provoked was 83%. Coronary vasospasticity persists to some extent in spite of complete remission of angina by medical treatment, and the type of spasm provoked has high reproducibility. Therefore, the cessation of drug treatment should be done carefully.
authors.affiliation: Sendai Cardiovascular Center.
authors.forename: T
authors.initials: T
authors.lastname: Byun
authors.forename: T
authors.initials: T
authors.lastname: Uchida
authors.forename: K
authors.initials: K
authors.lastname: Hirosawa
authors.forename: F
authors.initials: F
authors.lastname: Mori
authors.forename: H
authors.initials: H
authors.lastname: Oomori
authors.forename: M
authors.initials: M
authors.lastname: Nagashima
authors.forename: K
authors.initials: K
authors.lastname: Enta
authors.forename: S
authors.initials: S
authors.lastname: Kodama
authors.forename: S
authors.initials: S
authors.lastname: Kasahara
authors.forename: K
authors.initials: K
authors.lastname: Iwade
authors.forename: S
authors.initials: S
authors.lastname: Hosoda
mesh_terms: D000109:Acetylcholine; D000368:Aged; D000787:Angina Pectoris / Q000188:drug therapy*; D002121:Calcium Channel Blockers / Q000627:therapeutic use; D017023:Coronary Angiography; D003329:Coronary Vasospasm / Q000188:drug therapy / Q000209:etiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D012074:Remission Induction
chemical_list: D002121:Calcium Channel Blockers; D000109:Acetylcholine