title: Double identity for proteins of the Bcl-2 family.
abstract: Bcl-2 is an oncogenic protein that acts by inhibiting programmed cell death. The mechanisms used by this and related anti-apoptotic proteins to protect cells from cytotoxic stimuli are now emerging, with the discovery that Bcl-2 can function both as an ion channel and as an adaptor or docking protein.
authors.affiliation: Burnham Institute, Program on Apoptosis and Cell Death Research, La Jolla, California 92037, USA.
authors.forename: J C
authors.initials: JC
authors.lastname: Reed
mesh_terms: D000818:Animals; D017209:Apoptosis; D029742:Caenorhabditis elegans Proteins; D002135:Calcium-Binding Proteins / Q000378:metabolism*; D003600:Cytosol / Q000378:metabolism; D019281:Dimerization; D015801:Helminth Proteins / Q000378:metabolism*; D006801:Humans; D007425:Intracellular Membranes / Q000378:metabolism; D007473:Ion Channels / Q000737:chemistry / Q000502:physiology*; D011485:Protein Binding; D011487:Protein Conformation; D017433:Protein Structure, Secondary; D011518:Proto-Oncogene Proteins / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*; D051020:bcl-X Protein
chemical_list: C494811:BCL2L1 protein, human; D029742:Caenorhabditis elegans Proteins; D002135:Calcium-Binding Proteins; C089224:Ced-4 protein, C elegans; D015801:Helminth Proteins; D007473:Ion Channels; D011518:Proto-Oncogene Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D051020:bcl-X Protein