title: Haemostatic changes in patients with deep vein thrombosis.
abstract: Thrombomodulin (TM), beta-thromboglobulin (beta-TG), D-dimer (DD), tissue-type plasminogen-activator (t-PA), plasminogen activator-inhibitor (PAI-1) and quantitative determination of functional protein S (PS) were measured using ELISA procedures in the plasma of 16 untreated patients with newly-diagnosed deep vein thrombosis in the leg and in 10 healthy volunteers. No significant difference in plasma TM, t-PA and PS levels was observed among the controls and patients with deep vein thrombosis. These patients, on the other hand, showed plasma DD, beta-TG and PAI-1 levels significantly higher than the control subjects. These data show that in patients with deep vein thrombosis a hypercoagulable state is a common occurrence.
authors.affiliation: Chair of Angiology, Messina University, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Trifiletti
authors.forename: R
authors.initials: R
authors.lastname: Scamardi
authors.forename: M A
authors.initials: MA
authors.lastname: Pizzoleo
authors.forename: S
authors.initials: S
authors.lastname: Soraci
authors.forename: A
authors.initials: A
authors.lastname: Nevoso
authors.forename: L
authors.initials: L
authors.lastname: Bagnato
authors.forename: N
authors.initials: N
authors.lastname: Barbera
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis; D006487:Hemostasis; D006801:Humans; D008297:Male; D008875:Middle Aged; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood; D013924:Thrombophlebitis / Q000097:blood*; D001620:beta-Thromboglobulin / Q000032:analysis
chemical_list: D005338:Fibrin Fibrinogen Degradation Products; D017395:Plasminogen Activator Inhibitor 1; D001620:beta-Thromboglobulin; C036309:fibrin fragment D