title: Typhoid enteric perforation.
abstract: BACKGROUND
  Perforation of the bowel is the most serious complication of typhoid fever. The role of early limited surgery in managing these patients needs to be assessed.
  
  
  METHODS
  The records of 110 cases of typhoid enteric perforation treated at JLN Hospital, Ajmer between 1990 and 1995 were reviewed.
  
  
  RESULTS
  A total of 42.7% of the patients were in the 21-30-year age group, and 83.6% were male. All patients presented with the classic features of typhoid enteric perforation. A total of 83.6% were operated on within 36 h of perforation. Surgical management consisted of primary closure of the perforation (74.5%), closure with omental graft (14.5%), resection and anastomosis (3.6%), and only drainage (7.3%). A total of 79.1% of patients developed wound infection and 10% of patients developed faecal fistula. The overall mortality rate was 16.4%. Increasing the time interval between perforation and operation significantly increased the mortality (P < 0.05). The mortality was least with early primary closure of the perforation. Patients with postoperative faecal fistula had higher mortality rates (P < 0.001).
  
  
  CONCLUSIONS
  Early limited surgery with thorough peritoneal lavage provides optimal results, faecal fistula is a grave complication, and the use of the McBurney incision may provide better results in terms of subsequent wound healing.
authors.affiliation: Department of General Surgery, Jawahar Lal Nehru Medical College and Hospital, Ajmer, India.
authors.forename: S
authors.initials: S
authors.lastname: Talwar
authors.forename: R K
authors.initials: RK
authors.lastname: Sharma
authors.forename: D K
authors.initials: DK
authors.lastname: Mittal
authors.forename: P
authors.initials: P
authors.lastname: Prasad
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D002648:Child; D002675:Child, Preschool; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D007416:Intestinal Perforation / Q000175:diagnosis / Q000382:microbiology* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D012003:Rectal Fistula / Q000209:etiology; D012189:Retrospective Studies; D017678:Sex Distribution; D013530:Surgical Wound Infection / Q000209:etiology; D016019:Survival Analysis; D013997:Time Factors; D014435:Typhoid Fever / Q000150:complications*