title: Two-component signal transducers and MAPK cascades.
abstract: Two-component signal transducers, which are characterized by the histidine-to-aspartate phospho-transfer mechanism, were once thought to be restricted to prokaryotes. They have, however, now been identified in diverse eukaryotic species including plant, fungus, yeast and slime mold. In yeast, a two-component osmosensor has been found to regulate a mitogen-activated protein kinase (MAPK) cascade, a ubiquitous eukaryotic signaling module.
authors.affiliation: Division of Tumor Immunology, Dana-Farber Cancer Institute, Boston, MA, USA.
authors.forename: S M
authors.initials: SM
authors.lastname: Wurgler-Murphy
authors.forename: H
authors.initials: H
authors.lastname: Saito
mesh_terms: D001425:Bacterial Outer Membrane Proteins; D017871:Calcium-Calmodulin-Dependent Protein Kinases / Q000378:metabolism*; D029968:Escherichia coli Proteins; D005057:Eukaryotic Cells; D009097:Multienzyme Complexes; D010766:Phosphorylation; D010944:Plants; D011387:Prokaryotic Cells; D012441:Saccharomyces cerevisiae; D015398:Signal Transduction
chemical_list: D001425:Bacterial Outer Membrane Proteins; D029968:Escherichia coli Proteins; D009097:Multienzyme Complexes; D017871:Calcium-Calmodulin-Dependent Protein Kinases; C057843:envZ protein, E coli