Development and characterization of a mini capsular extrusion system for enteric delivery of metronidazole bearing liposomes.
A capsular extrusion system was developed for enteric delivery of metronidazole loaded liposomes. The system is essentially based on a miniosmotic pump except that the extrusion in the present system is brought about by the swelling of a swellable polymer which raises the vestibule and extrudes out the contents through a deliver orifice. Drug reservoir of the system contained freeze dried liposomes which become hydrated prior to extrusion. Extruded liposomes were uniform in size with 45-68% incorporation of metronidazole. When tested for in vitro antiamoebic and antibacterial activity it was found that the effectiveness of liposomal metronidazole was significantly higher as compared to the unformulated drug.
Singh
R
R
Department of Pharmaceutical Sciences, Dr. H.S. Gour Vishwavidyalaya, Sagar (MP), India.
Vyas
S P
SP
D000563:Amebicides / Q000008:administration & dosage*; D000818:Animals; D002214:Capsules; D016503:Drug Delivery Systems; D004355:Drug Stability; D007408:Intestinal Absorption; D008081:Liposomes; D008795:Metronidazole / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000494:pharmacology
D000563:Amebicides; D002214:Capsules; D008081:Liposomes; D008795:Metronidazole