Chronic infection of Balb/c mice with murine herpesvirus 72 is associated with neoplasm development.
One hundred Balb/c mice were infected with murine herpesvirus strain 72 (MHV-72) and observed for 2.5 years for neoplasm development and virus presence in tumour as well as non-tumour tissues. Out of 13 neoplasm-bearing mice the virus was recovered from solid tumours (one lymphoma, two non-differentiated lymphoblastomas and two fibrosarcomas) of five mice and from the spleen of one mouse with lymphatic leukemia. The virus persisted frequently also in various organs of the neoplasm-bearing mice.
Mistríkóva
J
J
Department of Microbiology and Virology, Faculty of Natural Sciences, Comenius University, Bratislava, Slovak Republic.
Rajcáni
J
J
Mrmusová
M
M
Oravcová
I
I
D000818:Animals; D002522:Chlorocebus aethiops; D002908:Chronic Disease; D018352:Coronavirus Infections / Q000473:pathology / Q000503:physiopathology / Q000821:virology*; D005354:Fibrosarcoma / Q000473:pathology / Q000821:virology*; D008223:Lymphoma / Q000473:pathology / Q000821:virology*; D051379:Mice; D008807:Mice, Inbred BALB C; D006517:Murine hepatitis virus / Q000302:isolation & purification* / Q000472:pathogenicity; D014709:Vero Cells