title: Association analysis of six candidate genes in a sample of Australian hypertensive patients.
abstract: 1. Essential hypertension is characterized by increased vascular resistance due to narrowing of the small arterioles. This may be influenced by vasoactive substances, cell growth and vascular remodelling. 2. A sample of Australian hypertensive and normotensive subjects was investigated for association with genetic markers which are candidates for a role in blood pressure (BP) regulation due to potential effects on vascular diameter. 3. The six markers used were for genes encoding vasoconstrictors, growth factors and a structural protein of the extracellular matrix. 4. No significant association of any of the markers used was found with BP status in this sample of patients.
authors.affiliation: Department of Medicine, University of Queensland, Prince Charles Hospital, Chermside, Australia.
authors.forename: P R
authors.initials: PR
authors.lastname: Huggard
authors.forename: K M
authors.initials: KM
authors.lastname: Summers
authors.forename: J
authors.initials: J
authors.lastname: West
authors.forename: M J
authors.initials: MJ
authors.lastname: West
mesh_terms: D000368:Aged; D000808:Angiotensinogen / Q000235:genetics; D001315:Australia / Q000453:epidemiology; D004198:Disease Susceptibility; D004549:Elastin / Q000235:genetics; D005260:Female; D005796:Genes; D006801:Humans; D006973:Hypertension / Q000453:epidemiology / Q000235:genetics*; D007610:Kallikreins / Q000235:genetics; D008297:Male; D008875:Middle Aged; D011972:Receptor, Insulin / Q000235:genetics; D011945:Receptors, Angiotensin / Q000235:genetics; D017451:Receptors, Somatomedin / Q000235:genetics
chemical_list: D011945:Receptors, Angiotensin; D017451:Receptors, Somatomedin; D000808:Angiotensinogen; D004549:Elastin; D011972:Receptor, Insulin; D007610:Kallikreins