title: Controlled dose confirmation study of a 2% moxidectin equine gel against equine internal parasites in The Netherlands.
abstract: The efficacy of a 2% moxidectin equine gel at a dosage rate of 0.4 mg kg-1 was evaluated in a controlled trial at Utrecht University. Twelve yearling castrated male Shetland ponies grazed a pasture of 2 ha from May 1994 until housing in November. Six ponies were treated with moxidectin, whereas the others served as non-treated controls. Necropsy was carried out 35 days after treatment. Greater than 99% efficacy of moxidectin was observed on faecal egg output. No effect of moxidectin was observed on mucosal inhibited early cyathostome L3 (EL3) or on the total numbers of mucosal developing stages. However, a 89.6% reduction was observed on large mucosal fourth stage larvae (L4). Moxidectin treatment probably triggered resumption of development of EL3. Moxidectin appeared to be highly effective (95-100%) on lumenal L4 cyathostomes, adult strongylids, Strongylus vulgaris larvae from the arteries, S. edentatus larvae from the abdominal wall and Trichostrongylus axei. Moxidectin had relatively poor efficacy against Gasterophilus intestinalis and had no effect on Anoplocephala perfoliata. No side-effects of moxidectin treatment were observed.
authors.affiliation: Department of Parasitology and Tropical Veterinary Medicine, Utrecht University, The Netherlands.
authors.forename: M
authors.initials: M
authors.lastname: Eysker
authors.forename: J H
authors.initials: JH
authors.lastname: Boersema
authors.forename: G C
authors.initials: GC
authors.lastname: Grinwis
authors.forename: F N
authors.initials: FN
authors.lastname: Kooyman
authors.forename: J
authors.initials: J
authors.lastname: Poot
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents; D000969:Antinematodal Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D007411:Intestinal Diseases, Parasitic / Q000188:drug therapy / Q000469:parasitology / Q000662:veterinary*; D007413:Intestinal Mucosa / Q000469:parasitology; D007814:Larva / Q000187:drug effects / Q000254:growth & development; D018942:Macrolides / Q000008:administration & dosage / Q000627:therapeutic use; D008297:Male; D009426:Netherlands; D010270:Parasite Egg Count / Q000662:veterinary; D013319:Strongyle Infections, Equine / Q000188:drug therapy* / Q000469:parasitology; D013320:Strongyloidea / Q000187:drug effects / Q000254:growth & development
chemical_list: D000900:Anti-Bacterial Agents; D000969:Antinematodal Agents; D018942:Macrolides; C027837:moxidectin