title: Drug therapy of severe hypercholesterolemia.
abstract: Lowering of plasma cholesterol and particularly of LDL cholesterol has been shown to be an effective way of primary and secondary prophylaxis of coronary heart disease. A broad range of drugs is available (bile acid binding resins, HMG CoA reductase inhibitors, fibrates, nicotinic acid, probucol, beta-sitosterol) for therapy. The choice of the drug is based on the efficacy, possible side effects and proven effects on coronary heart disease.
authors.affiliation: Med. Klinik des Heinrich Lanz Krankenhauses, Feldbergstr. 68-70, Mannheim D-68163, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Weizel
authors.forename: W O
authors.initials: WO
authors.lastname: Richter
mesh_terms: D000328:Adult; D000837:Anion Exchange Resins / Q000627:therapeutic use; D000924:Anticholesteremic Agents / Q000627:therapeutic use*; D002352:Carrier Proteins / Q000627:therapeutic use; D002411:Cation Exchange Resins / Q000627:therapeutic use; D008078:Cholesterol, LDL / Q000097:blood; D003327:Coronary Disease / Q000517:prevention & control; D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D006913:Hydroxysteroid Dehydrogenases; D006938:Hyperlipoproteinemia Type II / Q000097:blood / Q000188:drug therapy*; D000960:Hypolipidemic Agents / Q000627:therapeutic use*; D008297:Male; D008562:Membrane Glycoproteins; D045002:3-alpha-Hydroxysteroid Dehydrogenase (B-Specific)
chemical_list: D000837:Anion Exchange Resins; D000924:Anticholesteremic Agents; D002352:Carrier Proteins; D002411:Cation Exchange Resins; D008078:Cholesterol, LDL; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D006913:Hydroxysteroid Dehydrogenases; D000960:Hypolipidemic Agents; D008562:Membrane Glycoproteins; C037643:bile acid binding proteins; C435496:AKR1C2 protein, human; D045002:3-alpha-Hydroxysteroid Dehydrogenase (B-Specific)