Effect of prior nicotine treatment on drug induced changes in serum LH concentrations in rats.
The effect of daily injections of nicotine on drug induced changes in LH secretion was investigated in male rats. Daily administration of nicotine for 7 days resulted in decreased basal serum LH concentrations. Nicotine treatment blocked naloxone induced LH release and reduced LHRH induced increases in serum LH. Clonidine induced increases in serum LH were not altered by nicotine treatment and haloperidol treatment did not alter nicotine induced decreases in serum LH. In an acute study nicotine blocked LH secretion induced by the long acting opioid antagonist naltrexone. Collectively these results indicate that opioidergic neurons are involved in the reduction in serum LH that occurs following nicotine. They also indicate that chronic nicotine treatment can reduce the pituitary gland response to LHRH.
Hodson
C A
CA
Department of Obstetrics and Gynecology, School of Medicine, East Carolina University, Greenville, NC 27858, USA.
Davis
M C
MC
Burden
H W
HW
D000316:Adrenergic alpha-Agonists / Q000494:pharmacology; D000818:Animals; D003000:Clonidine / Q000494:pharmacology; D018492:Dopamine Antagonists / Q000494:pharmacology; D004334:Drug Administration Schedule; D004347:Drug Interactions; D007987:Gonadotropin-Releasing Hormone / Q000494:pharmacology; D006220:Haloperidol / Q000494:pharmacology; D007986:Luteinizing Hormone / Q000037:antagonists & inhibitors / Q000097:blood* / Q000378:metabolism; D008297:Male; D009270:Naloxone / Q000494:pharmacology; D009271:Naltrexone / Q000494:pharmacology; D009292:Narcotic Antagonists / Q000494:pharmacology; D018377:Neurotransmitter Agents / Q000494:pharmacology; D009538:Nicotine / Q000494:pharmacology*; D018722:Nicotinic Agonists / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013268:Stimulation, Chemical
D000316:Adrenergic alpha-Agonists; D018492:Dopamine Antagonists; D009292:Narcotic Antagonists; D018377:Neurotransmitter Agents; D018722:Nicotinic Agonists; D007987:Gonadotropin-Releasing Hormone; D009270:Naloxone; D009271:Naltrexone; D009538:Nicotine; D007986:Luteinizing Hormone; D006220:Haloperidol; D003000:Clonidine