title: Cutaneous heparin necrosis in a patient with heterozygous protein S deficiency.
abstract: A patient with heterozygous protein S deficiency experienced cutaneous necrosis following subcutaneous heparin administration. Deficiencies of both protein C and protein S, known risk factors for the more frequently encountered coumarin necrosis, may predispose patients to this complication of heparin therapy as well. The putative association of protein S deficiency with cutaneous heparin necrosis could not be proven, however, since attempts to reproduce the heparin necrosis were unsuccessful.
authors.affiliation: Department of Dermatology, 67th Combat Support Hospital/US Army MEDDAC, Würzburg, Germany.
authors.forename: L F
authors.initials: LF
authors.lastname: Libow
authors.forename: E A
authors.initials: EA
authors.lastname: DiPreta
authors.forename: D L
authors.initials: DL
authors.lastname: Dyksterhouse
mesh_terms: D000005:Abdomen; D000328:Adult; D005260:Female; D006493:Heparin / Q000008:administration & dosage / Q000009:adverse effects*; D006579:Heterozygote; D006801:Humans; D007279:Injections, Subcutaneous / Q000009:adverse effects; D009336:Necrosis; D020151:Protein C Deficiency; D018455:Protein S Deficiency / Q000150:complications* / Q000235:genetics; D012307:Risk Factors; D012883:Skin Ulcer / Q000209:etiology* / Q000473:pathology
chemical_list: D006493:Heparin