title: Expression and human chromosomal localization to 17q25 of the growth-regulated gene encoding the mitochondrial ribosomal protein MRPL12.
abstract: Mitochondrial activity requires the expression of nuclear genes, whose products are part of multiproteic complexes leading to ATP production and delivery. We recently characterized a growth-activated mRNA encoding the human mitochondrial ribosomal MRPL12 protein, which is thought to act as a translational regulator of mitochondrial mRNAs. We show here that MRPL12 mRNA expression is enhanced in growth-stimulated cells as a result of transcriptional activation, a feature lost in transformed cell lines. MRPL12 mRNA is highly expressed in the colon, in which a reduction in mitochondrial activity was shown to be associated with tumor formation. The human MRPL12 protein is encoded by a unique gene located on chromosome 17 (q25-qter). As no predisposition to colon cancer linked to this chromosomal region was hitherto reported, the MRPL12 gene might be involved in the process of differentiation of colonic epithelial cells.
authors.affiliation: Institut de Génétique Moléculaire, CNRS-UMR5535, BP5051, Montpellier, France.
authors.forename: L
authors.initials: L
authors.lastname: Marty
authors.forename: S
authors.initials: S
authors.lastname: Taviaux
authors.forename: P
authors.initials: P
authors.lastname: Fort
mesh_terms: D000818:Animals; D018797:Cell Cycle Proteins; D002454:Cell Differentiation / Q000235:genetics; D002455:Cell Division / Q000235:genetics; D002460:Cell Line; D002461:Cell Line, Transformed; D002886:Chromosomes, Human, Pair 17 / Q000235:genetics*; D003106:Colon / Q000166:cytology / Q000378:metabolism; D006224:Cricetinae; D005260:Female; D015870:Gene Expression; D006801:Humans; D008297:Male; D008928:Mitochondria / Q000235:genetics* / Q000378:metabolism; D009687:Nuclear Proteins / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D012269:Ribosomal Proteins / Q000235:genetics*; D014018:Tissue Distribution
chemical_list: D018797:Cell Cycle Proteins; C099418:MRPL12 protein, human; D009687:Nuclear Proteins; D012333:RNA, Messenger; D012269:Ribosomal Proteins