Alternative splicing of the FHIT gene in colorectal cancers.
In the present study, we examined the status of the FHIT gene in 112 colorectal cancer and 137 colorectal adenoma specimens. In a total of 5 specimens (4 colorectal cancers and 1 colorectal adenoma), a common smaller product was detected in addition to the normal size product. This smaller product had lost exon 4, the 5' noncoding region of the FHIT gene, owing to alternative splicing. Moreover, all of the 5 tumors with alternative splicing were located lower on the rectum than the anterior peritoneal reflection.
Hibi
K
K
Second Department of Surgery, Nagoya University School of Medicine, Showa-ku.
Taguchi
M
M
Nakamura
H
H
Hirai
A
A
Fujikake
Y
Y
Matsui
T
T
Kasai
Y
Y
Akiyama
S
S
Ito
K
K
Takagi
H
H
D017766:Acid Anhydride Hydrolases; D000236:Adenoma / Q000235:genetics; D017398:Alternative Splicing; D002277:Carcinoma / Q000235:genetics*; D015179:Colorectal Neoplasms / Q000235:genetics*; D006801:Humans; D009363:Neoplasm Proteins; D011506:Proteins / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics; D012334:RNA, Neoplasm / Q000235:genetics; D000099170:Bis(5'-adenosyl)triphosphatase
D017766:Acid Anhydride Hydrolases; D009363:Neoplasm Proteins; D011506:Proteins; D012333:RNA, Messenger; D012334:RNA, Neoplasm; D000099170:Bis(5'-adenosyl)triphosphatase