title: Initial genome scan of the NIMH genetics initiative bipolar pedigrees: chromosomes 1, 6, 8, 10, and 12.
abstract: A report on an initial genome screen on 540 individuals in 97 families was collected as part of the NIMH Genetics Initiative on Bipolar Disorder. Families were ascertained to be informative for genetic linkage and underwent a common ascertainment and assessment protocol at four clinical sites. The sample was genotyped for 65 highly polymorphic markers from chromosomes 1, 6, 8, 10, and 12. The average intermarker interval was 16 cM. Genotypic data was analyzed using affected sib pair, multipoint affected sib pair, and pedigree analysis methods. Multipoint methods gave lod scores of approximately two on chromosomes 1, 6, and 10. The peak lod score on chromosome 6 occurred at the end of the q-arm, at some distance from the 6p24-22 area previously implicated for schizophrenia. We are currently genotyping additional markers to reduce the intermarker interval around the signals. The interpretation of results from a genome screen of a complex disorder and the problem of achieving a balance between detecting false positive results and the ability to detect genes of modest effect are discussed.
authors.affiliation: Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri 63110-1093, USA. john@jpr.wustl.edu
authors.forename: J P
authors.initials: JP
authors.lastname: Rice
authors.forename: A
authors.initials: A
authors.lastname: Goate
authors.forename: J T
authors.initials: JT
authors.lastname: Williams
authors.forename: L
authors.initials: L
authors.lastname: Bierut
authors.forename: D
authors.initials: D
authors.lastname: Dorr
authors.forename: W
authors.initials: W
authors.lastname: Wu
authors.forename: S
authors.initials: S
authors.lastname: Shears
authors.forename: G
authors.initials: G
authors.lastname: Gopalakrishnan
authors.forename: H J
authors.initials: HJ
authors.lastname: Edenberg
authors.forename: T
authors.initials: T
authors.lastname: Foroud
authors.forename: J
authors.initials: J
authors.lastname: Nurnberger
authors.forename: E S
authors.initials: ES
authors.lastname: Gershon
authors.forename: S D
authors.initials: SD
authors.lastname: Detera-Wadleigh
authors.forename: L R
authors.initials: LR
authors.lastname: Goldin
authors.forename: J J
authors.initials: JJ
authors.lastname: Guroff
authors.forename: F J
authors.initials: FJ
authors.lastname: McMahon
authors.forename: S
authors.initials: S
authors.lastname: Simpson
authors.forename: D
authors.initials: D
authors.lastname: MacKinnon
authors.forename: M
authors.initials: M
authors.lastname: McInnis
authors.forename: O C
authors.initials: OC
authors.lastname: Stine
authors.forename: J R
authors.initials: JR
authors.lastname: DePaulo
authors.forename: M C
authors.initials: MC
authors.lastname: Blehar
authors.forename: T
authors.initials: T
authors.lastname: Reich
mesh_terms: D001714:Bipolar Disorder / Q000235:genetics*; D002878:Chromosomes, Human, Pair 1; D002879:Chromosomes, Human, Pair 10; D002881:Chromosomes, Human, Pair 12; D002896:Chromosomes, Human, Pair 6; D002898:Chromosomes, Human, Pair 8; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D015894:Genome, Human; D005838:Genotype; D006801:Humans; D008126:Lod Score; D008297:Male; D009315:National Institute of Mental Health (U.S.); D009679:Nuclear Family; D010375:Pedigree; D011110:Polymorphism, Genetic; D012984:Software; D014481:United States
chemical_list: D005819:Genetic Markers