Inhibition of gamma interferon synthesis by catecholamines.
In vitro incubation of Listeria monocytogenes immune spleen cells in the presence of the catecholamines epinephrine or norepinephrine inhibited the gamma interferon (IFN-gamma) synthesis induced by the mitogen PHA, in a manner that appeared to be concentration dependent. Moreover, the inhibitory effect of both catecholamines epinephrine and norepinephrine on the synthesis of IFN-gamma was prevented by incubating immune spleen cells in the presence of propranolol, a beta adrenergic antagonist agent.
Andrade-Mena
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CE
Laboratorio de Immunologia Centro, Universitario de Ciencias de la Salud, Universidad de Guadalajara, Mexico.
D000818:Animals; D002395:Catecholamines / Q000494:pharmacology*; D005260:Female; D007371:Interferon-gamma / Q000096:biosynthesis*; D008213:Lymphocyte Activation / Q000187:drug effects; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D011433:Propranolol / Q000494:pharmacology; D013936:Thymidine / Q000378:metabolism
D002395:Catecholamines; D007371:Interferon-gamma; D011433:Propranolol; D013936:Thymidine