title: [Synergistic action of penicillin and immunoglobulin for intravenous (IVIG) use].
abstract: Combined effects of intravenous immunoglobulin and antibiotic in killing bacteria are of interest with extending clinical use of IGIV. Since the agents differ in antibacterial activity exerted by each of them, and their influence on the other, it is difficult to evaluate the combined effect in vitro. In our experiments the titer of antibody, and the killing of B Streptococcus type 090R, phagocytosis by chemiluminescence were examined in opsonic mixture. This mixture consist of IVIG, fresh serum, and neutrophils plus penicillin or without. The effect of combined IVIG and penicillin was higher than the effects of separate activities on bacteria. This observations suggest that the combination of IVIG and penicillin potentially useful in the treatment of GBS infection in some cases.
authors.affiliation: Zakład Badania Surowic i Szczepionek PZH w Warszawie.
authors.forename: B
authors.initials: B
authors.lastname: Bucholc
authors.forename: W
authors.initials: W
authors.lastname: Banach
mesh_terms: D004338:Drug Combinations; D004357:Drug Synergism; D004797:Enzyme-Linked Immunosorbent Assay; D007070:Immunoglobulin A / Q000008:administration & dosage; D007074:Immunoglobulin G / Q000008:administration & dosage; D007075:Immunoglobulin M / Q000008:administration & dosage; D016756:Immunoglobulins, Intravenous; D008163:Luminescent Measurements; D008826:Microbial Sensitivity Tests; D010406:Penicillins / Q000008:administration & dosage*; D013291:Streptococcus / Q000187:drug effects; D005719:gamma-Globulins / Q000008:administration & dosage*
chemical_list: D004338:Drug Combinations; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D016756:Immunoglobulins, Intravenous; D010406:Penicillins; D005719:gamma-Globulins; C077495:immunoglobulin A, immunoglobulin G, immunoglobulin M drug combination; C031151:pepsinated immunoglobulin G; C060166:pentaglobulin