Molecular analyses of human immunodeficiency virus type 1 V3 region quasispecies derived from plasma and peripheral blood mononuclear cells of the first long-term-nonprogressing mother and child pair.
Molecular analyses were done for the V3 region quasispecies of human immunodeficiency virus type 1 (HIV-1) strains from plasma and peripheral blood mononuclear cells of the first HIV-1-infected long-term-nonprogressing mother-child pair whose members have survived for >13 years with stable CD4 T cell counts. There was a predominance of lower V3 loop charge and the absence of genotypic changes that are critical in phenotypic determination and tropism during HIV-1 infection. The intrahost genetic diversity between HIV-1 strains from the mother-child pair compared with HIV-1 strains from slow and rapid progressors suggested that a high genetic heterogeneity in HIV-1 strains from this HIV-1-infected long-term-nonprogressing mother and child pair was directly proportional to the length of their immunocompetent period.
Wang
B
B
Centers for Virus Research, Westmead Institutes for Health Research, Westmead Hospital, NSW, Sydney, Australia.
Ge
Y C
YC
Jozwiak
R
R
Bolton
W
W
Palasanthiran
P
P
Ziegler
J
J
Chang
J
J
Xiang
S H
SH
Cunningham
A L
AL
Saksena
N K
NK
D000595:Amino Acid Sequence; D018791:CD4 Lymphocyte Count; D004279:DNA, Viral / Q000097:blood / Q000235:genetics; D018450:Disease Progression; D019143:Evolution, Molecular; D005260:Female; D014644:Genetic Variation / Q000235:genetics*; D015699:HIV Envelope Protein gp120 / Q000235:genetics*; D015658:HIV Infections / Q000235:genetics / Q000276:immunology / Q000821:virology*; D015497:HIV-1 / Q000235:genetics* / Q000502:physiology; D006801:Humans; D007231:Infant, Newborn; D007963:Leukocytes, Mononuclear / Q000821:virology; D008969:Molecular Sequence Data; D010446:Peptide Fragments / Q000235:genetics*; D010802:Phylogeny; D012367:RNA, Viral / Q000097:blood / Q000235:genetics; D016415:Sequence Alignment; D017422:Sequence Analysis, DNA; D014779:Virus Replication
D004279:DNA, Viral; D015699:HIV Envelope Protein gp120; C059762:HIV envelope protein gp120 (305-321); D010446:Peptide Fragments; D012367:RNA, Viral