title: Differential expression of transcription factors in the accumbens of an animal model of ADHD.
abstract: Transcription factors have been used as neuronal markers in the nucleus accumbens (ACB) of male juvenile spontaneously hypertensive rats (SHR), an animal model of attention-deficit hyperactivity disorder (ADHD), to trace putative neural substrates. In SHR, immunocytochemistry and PC-assisted image analysis showed lower expression of pan-fos, c-fos, zif/268 in the shell, and the c-fos and zif/268 in the core, with an increased level of Jun-B in the core. The differential lower basal expression of transcription factors in the ACB of an animal model of ADHD implies a reduced number of modules and might represent a neural substrate of the attention deficits seen in SHR and children with ADHD at low motivational levels.
authors.affiliation: Institute Human Anatomy, Second University of Naples (SUN), Italy.
authors.forename: M
authors.initials: M
authors.lastname: Papa
authors.forename: J A
authors.initials: JA
authors.lastname: Sergeant
authors.forename: A G
authors.initials: AG
authors.lastname: Sadile
mesh_terms: D000818:Animals; D001289:Attention Deficit Disorder with Hyperactivity / Q000378:metabolism*; D015870:Gene Expression; D017781:Genes, Immediate-Early / Q000235:genetics*; D007124:Immunoenzyme Techniques; D008297:Male; D009714:Nucleus Accumbens / Q000378:metabolism*; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D014157:Transcription Factors / Q000378:metabolism*
chemical_list: D014157:Transcription Factors