title: Avirulence of LT2 strains of Salmonella typhimurium results from a defective rpoS gene.
abstract: In order to identify the genetic basis for the attenuation of Salmonella typhimurium LT2 strains, experiments were performed to identify a gene(s) which restores virulence to an avirulent LT2 strain. These and further experiments confirmed that an rpoS mutation is the sole determinant of the attenuation of S. typhimurium LT2.
authors.affiliation: Department of Microbiology, University of Alabama at Birmingham, USA.
authors.forename: W E
authors.initials: WE
authors.lastname: Swords
authors.forename: B M
authors.initials: BM
authors.lastname: Cannon
authors.forename: W H
authors.initials: WH
authors.lastname: Benjamin
mesh_terms: D000483:Alleles; D001426:Bacterial Proteins / Q000235:genetics*; D005798:Genes, Bacterial; D009154:Mutation; D012486:Salmonella typhimurium / Q000235:genetics / Q000472:pathogenicity*; D012808:Sigma Factor / Q000235:genetics*; D014774:Virulence
chemical_list: D001426:Bacterial Proteins; D012808:Sigma Factor; C069567:sigma factor KatF protein, Bacteria