Genetic factors associated with altered sodium transport in human hypertension: a twin study.
1. Na+/H+ antiporter/exchange activity (NHE) in human cheek epithelial cells was assessed in 288 female twins and siblings. The genetic contribution of factors to NHE activity was assessed in 128 matched twin pairs (76 monozygotic (MZ); 52 dizygotic (DZ)). 2. There was a small reduction in NHE with age and body mass index. The significant correlations (+/-their standard error (SE)) within MZ and DZ pairs of twins were 0.54 +/- 0.08 and 0.26 +/- 0.13, respectively, implying that genetic factors accounted for 54% of the variance in age-adjusted NHE. There was no cross-sectional relationship between NHE and measures of blood pressure. Based on within-pair differences, however, there was a weak negative association (r = 0.22; P < 0.05) between mean arterial pressure and NHE. 3. It remains to be determined whether NHE in cheek cells is associated with blood pressure tracking over time in young females.
Nowson
C A
CA
Department of Physiology, University of Melbourne, Parkville, Victoria, Australia. c.nowson@physiology.unimelb.edu.au
McMurchie
E J
EJ
Burnard
S L
SL
Head
R J
RJ
Boehm
J
J
Hoang
H N
HN
Hopper
J L
JL
Wark
J D
JD
D000293:Adolescent; D000328:Adult; D001794:Blood Pressure / Q000235:genetics; D002469:Cell Separation; D002648:Child; D003430:Cross-Sectional Studies; D004848:Epithelium / Q000378:metabolism; D005260:Female; D006801:Humans; D006973:Hypertension / Q000235:genetics* / Q000378:metabolism; D017136:Ion Transport / Q000235:genetics; D009061:Mouth Mucosa / Q000166:cytology / Q000378:metabolism; D012964:Sodium / Q000378:metabolism*; D017923:Sodium-Hydrogen Exchangers / Q000235:genetics*
D017923:Sodium-Hydrogen Exchangers; D012964:Sodium