title: [Cholesterol and development].
abstract: The teratogenic action of distal inhibitors of cholesterol synthesis has been known for some time. The induced malformations are of a particular type: they include holoprosencephalies. Recently these observations have solicited increased interest due to: 1/ the discovery in 1993 of a similar form of inhibition of cholesterol synthesis which is responsible for a human malformation syndrome, Smith-Lemli-Opitz; 2/ the demonstration of the involvement of the Sonic Hedgehog gene in normal development of prosencephalon and the description of the mode of action of the protein Shh: autoprocessing followed by "cholesterolisation".
authors.affiliation: Laboratoire d'Embryologie pathologique expérimentale, CHU Saint-Antoine, Paris.
authors.forename: C
authors.initials: C
authors.lastname: Roux
authors.forename: C
authors.initials: C
authors.lastname: Wolf
authors.forename: B
authors.initials: B
authors.lastname: Llirbat
authors.forename: M
authors.initials: M
authors.lastname: Kolf
authors.forename: N
authors.initials: N
authors.lastname: Mulliez
authors.forename: J L
authors.initials: JL
authors.lastname: Taillemite
authors.forename: V
authors.initials: V
authors.lastname: Cormier
authors.forename: M
authors.initials: M
authors.lastname: Le Merrer
authors.forename: F
authors.initials: F
authors.lastname: Chevy
authors.forename: D
authors.initials: D
authors.lastname: Citadelle
mesh_terms: D000818:Animals; D000924:Anticholesteremic Agents / Q000494:pharmacology; D002784:Cholesterol / Q000097:blood / Q000235:genetics / Q000494:pharmacology*; D005314:Embryonic and Fetal Development / Q000187:drug effects* / Q000235:genetics; D005796:Genes; D016142:Holoprosencephaly / Q000139:chemically induced / Q000209:etiology / Q000235:genetics; D066298:In Vitro Techniques; D051379:Mice; D051381:Rats; D001371:trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride / Q000494:pharmacology
chemical_list: D000924:Anticholesteremic Agents; D001371:trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride; D002784:Cholesterol