Protein folding: does diffusion determine the folding rate?
A major question about protein folding is whether the coming together by diffusion of different segments of the polypeptide chain is rate-determining. This seemingly simple question has been very difficult to answer experimentally, but a positive result has now been obtained with one small model protein.
Creighton
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European Molecular Biology Laboratory, Suite 312, 78 Marylebone High Street, London, W1M 4AP, UK.
D004058:Diffusion; D005026:Ethylene Glycols / Q000494:pharmacology; D007700:Kinetics; D008962:Models, Theoretical; D011487:Protein Conformation; D017510:Protein Folding; D014367:Tryptophan Synthase / Q000737:chemistry*; D014783:Viscosity
D005026:Ethylene Glycols; D014367:Tryptophan Synthase