[The effect of lithium oxybutyrate on the development of the fetus and progeny in alcoholic intoxication of male rats].
The effect of lithium hydroxybutyrate on the development of the fetus and offsprings was studied on a model of alcohol intoxication of male rats. Under such conditions lithium hydroxybutyrate relieved completely the negative action of alcohol on the reproductive function, according to all parameters. The learning ability of the offsprings and their behavioral disorders in a stress situation caused by alcohol were normalized. Two-week administration of 100 mg/kg lithium hydroxybutyrate had no negative effect on the embryonal and postnatal development of the offsprings.
Nemova
E P
EP
Krylova
A M
AM
Smol'nikova
N M
NM
Liubimov
B I
BI
D000375:Aging / Q000187:drug effects; D000435:Alcoholic Intoxication / Q000188:drug therapy* / Q000196:embryology; D000818:Animals; D000831:Animals, Newborn; D003214:Conditioning, Classical / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D005314:Embryonic and Fetal Development / Q000187:drug effects*; D004924:Escape Reaction / Q000187:drug effects; D005220:Fathers; D005260:Female; D006128:Growth / Q000187:drug effects*; D006885:Hydroxybutyrates / Q000494:pharmacology* / Q000627:therapeutic use; D008094:Lithium / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D009942:Organometallic Compounds / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats
D006885:Hydroxybutyrates; D009942:Organometallic Compounds; C022826:lithium hydroxybutyrate; D008094:Lithium