[The effect of perftoran on the resistance of mice to GABA receptor antagonists and on the antidote activity of anticonvulsant agents].
Perfluorane (a phenobarbital-type inducer of the microsomal enzyme system) raised the resistance of mice to the toxic effect of picrotoxin and bicucullin in 7 days after injection. The antidote effect of diazepam and phenobarbital increased under such conditions. In experiments in vitro a modulatory effect of perftorane on the central muscarine and benzodiazepine receptors was demonstrated.
Golovko
A I
AI
Kliuntina
T V
TV
Ivanov
M B
MB
Sofronov
G A
GA
Sviderskiĭ
O A
OA
Shilov
V V
VV
D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use*; D000931:Antidotes / Q000627:therapeutic use*; D001640:Bicuculline / Q000506:poisoning; D003975:Diazepam / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical; D004351:Drug Resistance; D004357:Drug Synergism; D005466:Fluorocarbons / Q000494:pharmacology / Q000627:therapeutic use*; D018756:GABA Antagonists / Q000506:poisoning*; D008297:Male; D051379:Mice; D010634:Phenobarbital / Q000627:therapeutic use; D010852:Picrotoxin / Q000506:poisoning; D011041:Poisoning / Q000188:drug therapy; D011963:Receptors, GABA-A / Q000187:drug effects; D011976:Receptors, Muscarinic / Q000187:drug effects
D000927:Anticonvulsants; D000931:Antidotes; D001640:Bicuculline; D003975:Diazepam; D005466:Fluorocarbons; D018756:GABA Antagonists; D010634:Phenobarbital; D010852:Picrotoxin; D011963:Receptors, GABA-A; D011976:Receptors, Muscarinic; C063334:perftoran