title: [Toxic properties of recombinant tumor necrosis factor].
abstract: Toxic properties of recombinant human tumor necrosis factor (TNF-beta) were studied on noninbred albino mice. In the maximum tolerable doses the preparation induced a decrease in the body weight and temperature of the animals as well as development of glyco- and leukopenic reactions and damage of the internal organ structures. The preparation effects were observed early after the exposure and were mainly reversible. The most TNF-beta sensitive organs were the liver, lungs, adrenal gland, thymus and spleen. The major link in the pathological process development under the effect of the TNF-beta toxic doses was likely increased intravascular blood coagulability evident from a marked procoagulant activity of the preparation.
authors.forename: V I
authors.initials: VI
authors.lastname: Masycheva
authors.forename: E D
authors.initials: ED
authors.lastname: Danilenko
authors.forename: E N
authors.initials: EN
authors.lastname: Morozova
authors.forename: L K
authors.initials: LK
authors.lastname: Fedosova
authors.forename: L Iu
authors.initials: LIu
authors.lastname: Sizova
authors.forename: S G
authors.initials: SG
authors.lastname: Gamaleĭ
authors.forename: L R
authors.initials: LR
authors.lastname: Lebedev
authors.forename: N M
authors.initials: NM
authors.lastname: Pustoshilova
mesh_terms: D000818:Animals; D001778:Blood Coagulation Disorders / Q000139:chemically induced; D001786:Blood Glucose / Q000378:metabolism; D001833:Body Temperature Regulation / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D002460:Cell Line; D006403:Hematologic Tests; D006801:Humans; D007962:Leukocytes / Q000187:drug effects; D008233:Lymphotoxin-alpha / Q000633:toxicity*; D051379:Mice; D009928:Organ Specificity; D011994:Recombinant Proteins / Q000633:toxicity
chemical_list: D001786:Blood Glucose; D008233:Lymphotoxin-alpha; D011994:Recombinant Proteins