[Effect of phenytoin and carbamazepine on evoked potentials in patients with newly diagnosed epilepsy. Part I. Visual evoked potentials].
Pattern-reversal visual evoked potentials (VEPs) were recorded in 64 patients with newly diagnosed epilepsy. Before starting medication the patients with partial and primary generalized epilepsy, had prolonged latencies of the VEPs component P100, as compared with controls. VEPs were repeated after 3 months in 43 patients with focal epilepsy, during carbamazepine (22 cases) or phenytoin (21 cases) treatment. The plasma concentration of the drugs were within therapeutic levels. Carbamazepine but not phenytoin, was associated with prolongation of the P100 peak latency and induced increase of its amplitude, as compared with the baseline condition. The VEPs abnormality was most pronounced in patients whose seizures were poorly controlled. We conclude, that administration of carbamazepine or phenytoin, at therapeutic serum level, have minimal effect on the VEPs.
Rysz
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Kliniki Neurochirurgii AM w Warszawie.
Gajkowski
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D000293:Adolescent; D000328:Adult; D000368:Aged; D000927:Anticonvulsants / Q000494:pharmacology* / Q000627:therapeutic use*; D002220:Carbamazepine / Q000494:pharmacology* / Q000627:therapeutic use*; D002648:Child; D004829:Epilepsy, Generalized / Q000188:drug therapy*; D005074:Evoked Potentials, Visual / Q000187:drug effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010672:Phenytoin / Q000494:pharmacology* / Q000627:therapeutic use*
D000927:Anticonvulsants; D002220:Carbamazepine; D010672:Phenytoin