Linear IgA bullous dermatosis after contact with sodium hypochlorite.
The onset of linear IgA bullous dermatosis (LABD) is generally spontaneous, but a number of cases of LABD have been reported either following drug exposure or in association with malignancies. We describe a patient who developed a vesicular eruption shortly after an irritant dermatitis caused by the contact with a detergent containing sodium hypochlorite. Direct immunofluorescence revealed linear deposits of IgA and C3 in the epidermal basement membrane. The patient's serum contained IgA that immunoblotted a 180-kD polypeptide in extracts of human keratinocytes. The patient responded promptly to therapy with dapsone. We suggest a possible pathogenetic relationship between the chemical dermatitis and LABD in this patient.
Pellicano
R
R
Department of Dermatology, IRCCS Hospital Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy.
Lomuto
M
M
Cozzani
E
E
Iannantuono
M
M
De Simone
C
C
D000328:Adult; D001485:Basement Membrane / Q000473:pathology; D003176:Complement C3 / Q000032:analysis; D003622:Dapsone / Q000627:therapeutic use; D017453:Dermatitis, Irritant / Q000209:etiology / Q000473:pathology; D003902:Detergents / Q000009:adverse effects; D004202:Disinfectants / Q000009:adverse effects*; D004817:Epidermis / Q000473:pathology; D005260:Female; D019085:Fluorescent Antibody Technique, Direct; D005493:Folic Acid Antagonists / Q000627:therapeutic use; D006801:Humans; D015151:Immunoblotting; D007070:Immunoglobulin A / Q000032:analysis / Q000097:blood; D015603:Keratinocytes / Q000473:pathology; D012872:Skin Diseases, Vesiculobullous / Q000139:chemically induced* / Q000473:pathology; D012973:Sodium Hypochlorite / Q000009:adverse effects*
D003176:Complement C3; D003902:Detergents; D004202:Disinfectants; D005493:Folic Acid Antagonists; D007070:Immunoglobulin A; D003622:Dapsone; D012973:Sodium Hypochlorite