title: RNA editing: getting U into RNA.
abstract: RNA editing in kinetoplastid protozoa remodels the sequences of mitochondrial pre-mRNAs by the precise insertion and deletion of uridylate residues. These sequence changes are directed by small trans-acting RNAs, termed guide RNAs. The basic mechanistic pathway by which edited RNA is generated has recently been elucidated using in vitro systems capable of a full round of guide-RNA-directed editing.
authors.affiliation: Seattle Biomedical Research Institute, WA 98109, USA.
authors.forename: M L
authors.initials: ML
authors.lastname: Kable
authors.forename: S
authors.initials: S
authors.lastname: Heidmann
authors.forename: K D
authors.initials: KD
authors.lastname: Stuart
mesh_terms: D001483:Base Sequence; D008969:Molecular Sequence Data; D012313:RNA / Q000737:chemistry / Q000378:metabolism; D017393:RNA Editing; D017394:RNA, Guide, Kinetoplastida; D012333:RNA, Messenger / Q000737:chemistry; D011993:Recombinant Fusion Proteins / Q000235:genetics; D014542:Uridine Monophosphate / Q000378:metabolism*
chemical_list: D012333:RNA, Messenger; D011993:Recombinant Fusion Proteins; D012313:RNA; D014542:Uridine Monophosphate; D017394:RNA, Guide, Kinetoplastida