[Changes in the nuclear morphometry in oropharyngeal epidermoid carcinoma after induction chemotherapy].
A cytomorphic, stereological study was made by computerized image analysis of six nuclear morphometric variables and one stereological nuclear variable. Variables were measured on 150 randomly selected tumor cells in oropharyngeal biopsies from 44 patients with oropharyngeal cancer who had not responded completely to induction chemotherapy. The nuclei of tumoral cells were larger (mean nuclear area, perimeter, and volume), more rounded, and had a less irregular nuclear contour index.
Santa Cruz Ruiz
S
S
Servicio de Otorrinoiaringología y Patologia Cérvico-Facial, Hospital Universitario de Salamanca.
Gómez González
J L
JL
Flores Corral
T
T
Del Cañizo Alvarez
A
A
D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000473:pathology*; D002945:Cisplatin / Q000008:administration & dosage / Q000627:therapeutic use*; D005472:Fluorouracil / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002955:Leucovorin / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009959:Oropharyngeal Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D009960:Oropharynx / Q000473:pathology*; D012189:Retrospective Studies
D000970:Antineoplastic Agents; D007166:Immunosuppressive Agents; D002945:Cisplatin; D002955:Leucovorin; D005472:Fluorouracil