title: Relationship between hepatitis C genotype and severity of recurrent hepatitis C after liver transplantation.
abstract: BACKGROUND
  Recurrence of hepatitis C virus (HCV) infection after liver transplantation is universal, but the relationship between hepatitis C genotype and posttransplant outcome has been controversial. The aim of this study was to assess the relationship between hepatitis C genotype on posttransplant frequency of recurrent hepatitis, histologic severity of recurrence, and progression to cirrhosis.
  
  
  METHODS
  We studied 42 HCV RNA positive patients who received transplants between 1985 and 1994. Sera were tested for HCV RNA and protocol liver biopsies were in obtained the posttransplant period. Biopsies were scored according to the histologic activity index (HAI) and staged in a blinded fashion.
  
  
  RESULTS
  The distribution of hepatitis C genotypes distribution was as follows: 1a, 19 (45%); 1b, 17 (40%); 2b, 3 (7%); and 1 each of 2a, 3a, and 4a. There was histologic evidence of hepatitis in 38 of 42 (90.4%) of patients. Hepatitis C was mild, moderate, or severe (HAI>3) in 38% of grafts and minimal (HAI 0-3) in 62%. Overall HAI scores and histologic stage were higher in the genotype 1b group. Six of 17 (35%) genotype 1b patients had cirrhosis compared with 2 of 25 (8%) in the non-1b genotype group.
  
  
  CONCLUSIONS
  (1) Histologic evidence of recurrent hepatitis C is seen in 90% of liver allografts; (2) Histologic hepatitis C recurs with similar frequency in genotype 1b and non-1b recipients; (3) Genotype 1b is associated with more severe histologic disease recurrence than non-1b genotypes; (4) Genotype 1b appears to be associated with a higher degree of posttransplant fibrosis and cirrhosis than non-1b genotypes.
authors.affiliation: Department of Laboratory Medicine and Pathology, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA.
authors.forename: F D
authors.initials: FD
authors.lastname: Gordon
authors.forename: J J
authors.initials: JJ
authors.lastname: Poterucha
authors.forename: J
authors.initials: J
authors.lastname: Germer
authors.forename: N N
authors.initials: NN
authors.lastname: Zein
authors.forename: K P
authors.initials: KP
authors.lastname: Batts
authors.forename: J B
authors.initials: JB
authors.lastname: Gross
authors.forename: R
authors.initials: R
authors.lastname: Wiesner
authors.forename: D
authors.initials: D
authors.lastname: Persing
mesh_terms: D000328:Adult; D001706:Biopsy; D005260:Female; D005838:Genotype; D006084:Graft Rejection / Q000503:physiopathology; D006526:Hepatitis C / Q000209:etiology* / Q000235:genetics*; D006801:Humans; D008099:Liver / Q000473:pathology; D008103:Liver Cirrhosis / Q000453:epidemiology; D016031:Liver Transplantation / Q000009:adverse effects / Q000276:immunology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012367:RNA, Viral / Q000032:analysis; D012008:Recurrence; D012086:Reoperation / Q000401:mortality; D015996:Survival Rate
chemical_list: D012367:RNA, Viral