title: The atrial natriuretic peptide receptor antagonist HS 142-1 improves cardiovascular filling and mean arterial pressure in a hyperdynamic ovine model of sepsis.
abstract: OBJECTIVE
  To test whether systemic vascular resistance and mean arterial pressure increase during the administration of the atrial natriuretic peptide antagonist, HS 142-1, in ovine experimental hyperdynamic sepsis.
  
  
  METHODS
  Prospective trial.
  
  
  METHODS
  Research laboratory at a large university medical center.
  
  
  METHODS
  Chronically instrumented Merino breed ewes (n = 14).
  
  
  METHODS
  Continuous infusion of Pseudomonas aeruginosa (2.5 x 10(6) colony-forming units/min) for the experimental period of 48 hrs. One group (HS 142-1) received a continuous infusion of HS 142-1 (3 mg/kg/hr) from 40 to 48 hrs; the remaining sheep ("control") were given the vehicle sodium chloride 0.9%.
  
  
  RESULTS
  All sheep developed a hyperdynamic cardiovascular response by 40 hrs that was characterized by low values of systemic vascular resistance index (p < .05) and mean arterial pressure (p < .05), and an increased cardiac index (p < .05). HS 142-1 increased cardiac filling pressures (p < .05) without apparent effects on fluid balance, and was associated with a significantly (p < .05) higher mean arterial pressure than was found in the control group at 44 and 48 hrs. HS 142-1 did not change systemic vascular resistance index. At 44 and 48 hrs, cardiac index values were found to have significantly (p < .05) increased in the animals receiving HS 142-1, when these data were compared with cardiac output values at 40 hrs.
  
  
  CONCLUSIONS
  HS 142-1 increases cardiac filling pressures and maintains mean arterial pressure in hyperdynamic sepsis without reversal of sepsis-induced vasodilation.
authors.affiliation: Department of Anesthesiology, University of Texas Medical Branch, Galveston 77555-0833, USA.
authors.forename: F
authors.initials: F
authors.lastname: Hinder
authors.forename: M
authors.initials: M
authors.lastname: Booke
authors.forename: L D
authors.initials: LD
authors.lastname: Traber
authors.forename: D L
authors.initials: DL
authors.lastname: Traber
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D011134:Polysaccharides / Q000494:pharmacology / Q000627:therapeutic use*; D017461:Receptors, Atrial Natriuretic Factor / Q000037:antagonists & inhibitors*; D018805:Sepsis / Q000188:drug therapy*; D012756:Sheep
chemical_list: C072551:HS 142-1; D011134:Polysaccharides; D017461:Receptors, Atrial Natriuretic Factor