title: Peoscopic diagnosis of flat condyloma and penile intraepithelial neoplasia. Clinical manifestation.
abstract: Peoscopy was performed in order to assess penile lesions in the male sexual partners of 326 women with cervical intraepithelial neoplasia (CIN) or flat condyloma (FC). Each patient was submitted to a careful naked-eye inspection, peoscopy and biopsy of any suspicious lesion which was confirmed histologically and immunohistochemically. A brush cytologic examination of the distal portion of the urethra was also performed. The distribution of penile lesions was as follows: (1) 8 patients with herpes virus infection; (2) 37 patients with condyloma accuminata (CA); (3) 89 patients with FC; (4) 51 patients with FC and CA; (5) 18 patients with penile intraepithelial neoplasia grade 1 (PIN-I); (6) 2 patients with PIN-II; (7) 17 patients with PIN-III; (8) 92 patients with no penile lesions; (9) 7 patients with human papilloma virus infection of papillae coronae glandis, and (10) 5 patients with FC of the distal portion of the urethra. Naked-eye inspection revealed the presence of penile lesions in 39 of 233 patients (16.73%). Peoscopic examination revealed the presence of penile lesions in 233 of 326 patients (71.48%). In 135 of 155 patients the peoscopic findings were in accordance with the histologic diagnosis (87.09%). Immunohistochemical (by indirect peroxidase-antiperoxidase method) detection of virus antigens was positive in 16 of 34 patients (47.03%). It is concluded that peoscopy of the male sexual partners of women with CIN or FC should be performed to better assess the treatment used in the couple.
authors.affiliation: Department of Obstetrics and Gynecology, University of Patras, Rio, Greece.
authors.forename: E
authors.initials: E
authors.lastname: Cardamakis
authors.forename: I G
authors.initials: IG
authors.lastname: Kotoulas
authors.forename: K
authors.initials: K
authors.lastname: Relakis
authors.forename: K
authors.initials: K
authors.lastname: Metalinos
authors.forename: E
authors.initials: E
authors.lastname: Stathopoulos
authors.forename: A
authors.initials: A
authors.lastname: Diamantis
authors.forename: A
authors.initials: A
authors.lastname: Korantzis
authors.forename: J
authors.initials: J
authors.lastname: Michopoulos
authors.forename: C
authors.initials: C
authors.lastname: Mantouvalos
authors.forename: V
authors.initials: V
authors.lastname: Tzingounis
mesh_terms: D000956:Antigens, Viral / Q000032:analysis; D001706:Biopsy; D002278:Carcinoma in Situ / Q000453:epidemiology / Q000473:pathology*; D003218:Condylomata Acuminata / Q000453:epidemiology / Q000473:pathology*; D003937:Diagnosis, Differential; D004724:Endoscopy; D005260:Female; D006566:Herpesviridae Infections / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D015994:Incidence; D008297:Male; D027383:Papillomaviridae; D030361:Papillomavirus Infections / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology; D010412:Penile Neoplasms / Q000453:epidemiology / Q000473:pathology*; D010413:Penis / Q000276:immunology / Q000473:pathology*; D012307:Risk Factors; D014412:Tumor Virus Infections / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology; D014846:Vulvar Neoplasms / Q000453:epidemiology
chemical_list: D000956:Antigens, Viral