title: Recombinant RFB4 single-chain immunotoxin that is cytotoxic towards CD22-positive cells.
authors.affiliation: Laboratory of Molecular Biology, DBS, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
authors.forename: E
authors.initials: E
authors.lastname: Mansfield
authors.forename: M F
authors.initials: MF
authors.lastname: Chiron
authors.forename: P
authors.initials: P
authors.lastname: Amlot
authors.forename: I
authors.initials: I
authors.lastname: Pastan
authors.forename: D J
authors.initials: DJ
authors.lastname: FitzGerald
mesh_terms: D036002:ADP Ribose Transferases; D000911:Antibodies, Monoclonal / Q000096:biosynthesis*; D015703:Antigens, CD / Q000502:physiology*; D000944:Antigens, Differentiation, B-Lymphocyte / Q000502:physiology*; D001427:Bacterial Toxins; D002051:Burkitt Lymphoma; D015815:Cell Adhesion Molecules; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D003001:Cloning, Molecular; D017931:DNA Primers; D005098:Exotoxins / Q000096:biosynthesis / Q000633:toxicity*; D006801:Humans; D007074:Immunoglobulin G; D007143:Immunoglobulin Heavy Chains / Q000096:biosynthesis; D007147:Immunoglobulin Light Chains / Q000096:biosynthesis; D000922:Immunotoxins / Q000633:toxicity*; D037102:Lectins; D015458:Leukemia, T-Cell; D016297:Mutagenesis, Site-Directed; D016133:Polymerase Chain Reaction; D011993:Recombinant Fusion Proteins / Q000096:biosynthesis / Q000633:toxicity; D051918:Sialic Acid Binding Ig-like Lectin 2; D014407:Tumor Cells, Cultured; D037521:Virulence Factors; D000097668:Pseudomonas aeruginosa Exotoxin A
chemical_list: D036002:ADP Ribose Transferases; D000911:Antibodies, Monoclonal; D015703:Antigens, CD; D000944:Antigens, Differentiation, B-Lymphocyte; D001427:Bacterial Toxins; D015815:Cell Adhesion Molecules; D017931:DNA Primers; D005098:Exotoxins; D007074:Immunoglobulin G; D007143:Immunoglobulin Heavy Chains; D007147:Immunoglobulin Light Chains; D000922:Immunotoxins; D037102:Lectins; D011993:Recombinant Fusion Proteins; D051918:Sialic Acid Binding Ig-like Lectin 2; D037521:Virulence Factors; D000097668:Pseudomonas aeruginosa Exotoxin A; C497867:CD22 protein, human