title: Threonine allele in codon 54 of the fatty acid binding protein 2 gene does not modify the fatty acid composition of serum lipids in obese subjects.
abstract: Intestinal fatty acid binding protein (I-FABP) participates in the metabolism of fatty acids in the intestinal enterocytes. Threonine encoding allele in codon 54 of the I-FABP gene has been suggested as regulating the absorption of long-chain fatty acids. We examined the fatty acid composition of serum lipid fractions and the concentration of serum free fatty acids after an overnight fast in obese subjects, aged 24-56 years, on their habitual diet. The body mass index of the subjects ranged from 29.7 to 43.3 kg m-2. Six subjects were homozygous for the Thr-54 allele of the I-FABP gene, 37 subjects were heterozygous for the Thr-54/Ala-54 allele and 24 subjects were homozygous for the Ala-54 allele. We did not find any consistent differences in the proportions of long-chain fatty acids in serum triglycerides, cholesterol esters or phospholipids, but the concentration of serum free fatty acids tended to be higher in subjects who were homozygous for the Thr-54 allele (P = 0.13, for trend). In conclusion, our findings suggest that a polymorphism at codon 54 of the I-FABP2 gene does not substantially modify the fatty acid composition of serum lipids in obese Finns.
authors.affiliation: Department of Clinical Nutrition, University of Kuopio, Finland.
authors.forename: H M
authors.initials: HM
authors.lastname: Vidgren
authors.forename: R H
authors.initials: RH
authors.lastname: Sipiläinen
authors.forename: S
authors.initials: S
authors.lastname: Heikkinen
authors.forename: M
authors.initials: M
authors.lastname: Laakso
authors.forename: M I
authors.initials: MI
authors.lastname: Uusitupa
mesh_terms: D000328:Adult; D000409:Alanine / Q000235:genetics; D000483:Alleles; D002352:Carrier Proteins / Q000235:genetics*; D003062:Codon; D000071438:Fatty Acid-Binding Protein 7; D050556:Fatty Acid-Binding Proteins; D005227:Fatty Acids / Q000097:blood*; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D005387:Finland; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D018996:Myelin P2 Protein / Q000235:genetics*; D009363:Neoplasm Proteins; D009765:Obesity / Q000097:blood*; D013912:Threonine / Q000235:genetics*; D014280:Triglycerides / Q000097:blood; D025521:Tumor Suppressor Proteins
chemical_list: D002352:Carrier Proteins; D003062:Codon; C493404:FABP2 protein, human; C107608:FABP7 protein, human; C493405:Fabp2 protein, mouse; D000071438:Fatty Acid-Binding Protein 7; D050556:Fatty Acid-Binding Proteins; D005227:Fatty Acids; D005230:Fatty Acids, Nonesterified; D008055:Lipids; D018996:Myelin P2 Protein; D009363:Neoplasm Proteins; D014280:Triglycerides; D025521:Tumor Suppressor Proteins; D013912:Threonine; D000409:Alanine