title: BCL-6 and other genomic alterations in non-Hodgkin's lymphoma (NHL).
abstract: This study reports on the frequency and disease association pattern of a number of gene rearrangements in a large panel of lymphoid tumours (n = 94). We detected the t(11;14) translocation, involving rearrangement of the BCL-1 locus, in 60% of mantle cell lymphomas. The BCL-2 gene, located at band 18q21, was rearranged in 42% of follicle centre lymphomas (FCL) and in 15% of diffuse large B-cell (DLBC) lymphomas. In this study, 80% of the c-MYC rearrangements were detected in aggressive diffuse lymphoma subsets but, interestingly, 9% of FCL showed involvement of t(8q24) translocation. In our study, rearrangements of the BCL-6 gene at band 3q27 were found in 31% of DLBC lymphomas. Interestingly, 50% of the BCL-6 rearrangement positive lymphoma cases had coexisting gene rearrangements involving all of the aforementioned gene loci. The molecular dissection of these genes will improve our understanding of the genesis of the diverse clinicopathological subtypes.
authors.affiliation: Department of Medical Oncology and Pathology, Mater Misericordiae Hospital, Dublin, Ireland.
authors.forename: M
authors.initials: M
authors.lastname: Butler
authors.forename: N
authors.initials: N
authors.lastname: Corbally
authors.forename: P A
authors.initials: PA
authors.lastname: Dervan
authors.forename: D N
authors.initials: DN
authors.lastname: Carney
mesh_terms: D004268:DNA-Binding Proteins / Q000235:genetics*; D015321:Gene Rearrangement; D016259:Genes, myc; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000235:genetics*; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000235:genetics; D051560:Proto-Oncogene Proteins c-bcl-6; D011519:Proto-Oncogenes; D014157:Transcription Factors / Q000235:genetics*; D014178:Translocation, Genetic
chemical_list: D004268:DNA-Binding Proteins; D011518:Proto-Oncogene Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D051560:Proto-Oncogene Proteins c-bcl-6; D014157:Transcription Factors