Indicators of platelet turnover in thrombocytopenic infants.
Glycocalicin has been found to be a marker of increased platelet turnover, while interleukin-6 may be increased in response to thrombocytopenia. We used these markers to study the pathophysiology of thrombocytopenia in newborn infants. Cord blood platelet counts were obtained from 499 infants. Thrombocytopenic infants (< 100,000/mm3) and a control group had ELISA assays for interleukin-6 and glycocalicin performed. The mean levels of glycocalicin and interleukin-6 were elevated in cord blood of thrombocytopaenic infants. Infants with intrauterine growth restriction and thrombocytopaenia had no detectable glycocalicin in their plasma, despite elevated levels of interleukin-6. This probably reflects impaired thrombopoiesis in these infants.
Sciscione
A C
AC
Department of Gynaecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Bessos
H
H
Callan
N
N
Blakemore
K
K
Kickler
T
T
D001792:Blood Platelets / Q000378:metabolism*; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005312:Fetal Blood / Q000737:chemistry; D005317:Fetal Growth Retardation / Q000150:complications; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D015850:Interleukin-6 / Q000097:blood*; D010975:Platelet Aggregation Inhibitors / Q000378:metabolism*; D010976:Platelet Count; D019038:Platelet Glycoprotein GPIb-IX Complex / Q000378:metabolism*; D013921:Thrombocytopenia / Q000209:etiology / Q000276:immunology* / Q000378:metabolism*
D015850:Interleukin-6; D010975:Platelet Aggregation Inhibitors; D019038:Platelet Glycoprotein GPIb-IX Complex; C023592:glycocalicin