Lymphocyte infusion for delayed extramedullary relapse of acute leukemia following bone marrow transplantation.
We report a case of extramedullary relapse of acute myelogenous leukemia twelve years after allogeneic bone marrow transplantation. Due to the localized nature of the relapse, we were able to eliminate a majority of the tumor burden, utilizing local irradiation. Destined with eventual systemic leukemia relapse, further therapy utilizing donor lymphocytes was given at a time of minimal disease burden. The patient remains in a state of complete remission.
Fleming
D R
DR
Department of Medicine, University of Kentucky Markey Cancer Center, Lexington, USA.
Greenwood
M E
ME
Garrison
J
J
Geil
J D
JD
Romond
E H
EH
D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use; D016026:Bone Marrow Transplantation; D003131:Combined Modality Therapy; D016371:Cranial Irradiation; D005260:Female; D006801:Humans; D015479:Leukemia, Myelomonocytic, Acute / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy / Q000628:therapy*; D017254:Leukemic Infiltration / Q000628:therapy; D017710:Lymphocyte Transfusion; D008437:Maxilla / Q000473:pathology; D009915:Orbit / Q000473:pathology; D012008:Recurrence; D012074:Remission Induction; D016879:Salvage Therapy; D014184:Transplantation, Homologous