The effects of hormone replacement therapy on coronary heart disease.
The importance of cardiovascular disease as a cause of morbidity and mortality in women is well appreciated. Cardiovascular disease accounts for approximately 48% of deaths in women in the United States. In particular, coronary heart disease (CHD) accounts for approximately one-half of these deaths. This article describes current evidence that suggests it is premature to recommend hormone replacement therapy (HRT) as a proven prevention strategy for CHD.
Sotelo
M M
MM
Department of Internal Medicine, University of Iowa Hospitals and Clinics, Iowa City, USA.
Johnson
S R
SR
D015982:Bias; D003327:Coronary Disease / Q000378:metabolism / Q000517:prevention & control*; D004359:Drug Therapy, Combination; D015914:Estrogen Replacement Therapy; D005260:Female; D006801:Humans; D008074:Lipoproteins / Q000378:metabolism; D008593:Menopause / Q000187:drug effects* / Q000378:metabolism; D011372:Progestins / Q000627:therapeutic use; D016032:Randomized Controlled Trials as Topic
D008074:Lipoproteins; D011372:Progestins