title: Ménétrier's disease: a new variant with duodenal involvement.
abstract: Ménétrier's disease is a rare cause of hypertrophic gastropathy, usually confined to gastric body and fundus, which is characterized by giant rugae, hypoalbuminemia, and foveolar hyperplasia. The etiology of this disease is still unknown. We report a case of a 74-yr-old man who had dyspepsia, hypoalbuminemia, weight loss, and diffuse polypoid, nodular lesions affecting the whole stomach and proximal duodenum on gastroscopy and barium meal study. The histology of gastric and duodenal mucosal lesions fulfilled the diagnosis of Ménétrier's disease, that was not described to involve duodenum in the literature. The disease resolved clinically, endoscopically, and pathologically after therapy with famotidine for 3 months. We speculated that extensive pyloric metaplasia and then foveolar hyperplasia of duodenum in this patient might be a variant of Ménétrier's disease with favorable clinical course.
authors.affiliation: Department of Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan, Republic of China.
authors.forename: C S
authors.initials: CS
authors.lastname: Wu
authors.forename: C J
authors.initials: CJ
authors.lastname: Lin
authors.forename: T C
authors.initials: TC
authors.lastname: Chen
authors.forename: P C
authors.initials: PC
authors.lastname: Chen
authors.forename: C C
authors.initials: CC
authors.lastname: Chiu
mesh_terms: D000368:Aged; D001466:Barium Sulfate; D003287:Contrast Media; D004378:Duodenal Diseases / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000473:pathology*; D015738:Famotidine / Q000627:therapeutic use; D005748:Gastric Fundus / Q000473:pathology; D005753:Gastric Mucosa / Q000473:pathology; D005758:Gastritis, Hypertrophic / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000473:pathology*; D005773:Gastroscopy; D006635:Histamine H2 Antagonists / Q000627:therapeutic use; D006801:Humans; D006965:Hyperplasia; D007413:Intestinal Mucosa / Q000473:pathology; D008297:Male; D008679:Metaplasia; D011708:Pylorus / Q000473:pathology; D011859:Radiography; D012709:Serum Albumin / Q000032:analysis; D013270:Stomach / Q000000981:diagnostic imaging / Q000473:pathology; D015431:Weight Loss
chemical_list: D003287:Contrast Media; D006635:Histamine H2 Antagonists; D012709:Serum Albumin; D001466:Barium Sulfate; D015738:Famotidine