Unusual chromosome abnormalities in primary central nervous system lymphoma.
Primary central nervous system (PCNS) lymphoma is a relatively rare disease. The Epstein-Barr virus (EBV) has often been implicated in the development of lymphomas. Few cytogenetic. studies on PCNS lymphomas have been reported. We describe here an unusual case of PCNS B cell lymphoma, centroblastic polymorphic type without coexistent immune deficiency. The cytogenetic study showed unusual abnormalities: t(l;9) (q25;p21); del (6) (q14 q25), trisomy 12 and in addition one clone with trisomy 7 and loss of chromosome X. We did not observe any chromosome 14 abnormality, which is more commonly reported in PCNS lymphomas.
Zattara-Cannoni
H
H
Cytogenetic Oncology Laboratory, C.H.U. Timone-Marseilles, France.
Horshowski
N
N
Figarella-Branger
D
D
Dufour
H
H
Grisoli
F
F
Vagner-Capodano
A M
AM
D000368:Aged; D001932:Brain Neoplasms / Q000235:genetics* / Q000473:pathology; D002872:Chromosome Deletion; D002878:Chromosomes, Human, Pair 1 / Q000648:ultrastructure*; D002881:Chromosomes, Human, Pair 12; D002897:Chromosomes, Human, Pair 7; D002899:Chromosomes, Human, Pair 9 / Q000648:ultrastructure*; D005260:Female; D005625:Frontal Lobe; D006801:Humans; D007621:Karyotyping; D008228:Lymphoma, Non-Hodgkin / Q000235:genetics* / Q000473:pathology; D013788:Thalamus; D014178:Translocation, Genetic; D014314:Trisomy; D014960:X Chromosome