Endoscopic bile duct stent placement as a predictor of outcome following endoscopic sphincterotomy in patients with suspected sphincter of Oddi dysfunction.
OBJECTIVE
To determine whether symptomatic improvement following placement of endoscopic stent across the biliary sphincter could predict the longer-term clinical outcome after endoscopic sphincterotomy (ES).


METHODS
Twenty-three post-cholecystectomy patients with suspected sphincter of Oddi dysfunction underwent, sequentially, sphincter of Oddi manometry, endoscopic stent placement, ES, and follow-up for a further 6-12 months.


RESULTS
Eight (35%) patients either did not respond (n = 5), did not tolerate the stent (n = 1) or relapsed during stenting (n = 2). Only the patient who did not tolerate the stent from the outset (12%) improved after ES. Of five patients who responded to stenting and had ES within 8 weeks, only two (40%) remained asymptomatic. In contrast, of 10 patients who were pain-free during 12-14 weeks of stenting, nine (90%) continued to be asymptomatic after ES. All seven patients with an elevated sphincter of Oddi pressure responded to stenting and six benefited from sphincter ablation. Five (31%) of 16 patients who had normal sphincter pressure and had improvement after 12-14 weeks of stenting remained free from pain following ES. ES resulted in long-term freedom from pain in 12 of the 23 patients: six of the seven patients with elevated sphincter of Oddi pressure and six of the 16 subjects with normal manometry (P < 0.05).


CONCLUSIONS
Freedom from symptoms during at least 12 weeks of stenting predicted a favourable outcome after ES, irrespective of sphincter of Oddi pressure. Patients who failed to improve or showed improvement only with short-term stenting were less likely to benefit.
Rolny
P
P
Department of Medicine, Ostra University Hospital Gothenburg, Sweden.
D000328:Adult; D002763:Cholecystectomy / Q000009:adverse effects; D003135:Common Bile Duct / Q000503:physiopathology / Q000601:surgery*; D003137:Common Bile Duct Diseases / Q000503:physiopathology / Q000601:surgery; D016099:Endoscopy, Gastrointestinal; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008365:Manometry; D008875:Middle Aged; D011183:Postoperative Complications / Q000601:surgery; D011237:Predictive Value of Tests; D011312:Pressure; D012086:Reoperation; D012189:Retrospective Studies; D009803:Sphincter of Oddi / Q000503:physiopathology / Q000601:surgery*; D016717:Sphincterotomy, Endoscopic / Q000379:methods*; D015607:Stents; D013997:Time Factors; D016896:Treatment Outcome