Decreased level of light-induced Fos expression in the suprachiasmatic nucleus of diabetic rats.
We assessed light-induced Fos-immunoreactive cells in the suprachiasmatic nucleus of diabetic rats. The number of Fos-immunoreactive cells significantly decreased in diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats as compared with control Long-Evans Tokushima Otsuka (LETO) rats. In contrast there was no decrease in the number of Fos-immunoreactive cells in young OLETF rats which have not yet developed diabetes. Two months after the administration of streptozotocin (STZ) to Wistar rats, the number of Fos-immunoreactive cells significantly decreased, although 1 week after the administration of STZ, the number had not yet changed in these STZ-induced diabetic rats. These results suggest that chronic diabetic (hyperglycemic) conditions may affect the light entraining responses in the suprachiasmatic nucleus (SCN).
Yamanouchi
S
S
Department of Pharmacology, Faculty of Pharmaceutical Science, Kyushu University, Fukuoka, Japan.
Shimazoe
T
T
Nagata
S
S
Moriya
T
T
Maetani
M
M
Shibata
S
S
Watanabe
S
S
Miyasaka
K
K
Kono
A
A
Funakoshi
A
A
D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D008027:Light; D008297:Male; D016760:Proto-Oncogene Proteins c-fos / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D013493:Suprachiasmatic Nucleus / Q000378:metabolism*
D016760:Proto-Oncogene Proteins c-fos