Synthesis and biological activities of higher homologues of retinoic acid.
Homoretinoic and bishomoretinoic acid have been synthesized. Fast reaction under ultrasonic activation (Wolff rearrangement, saponification) produced compounds in high yields. Only the bishomo analogue exhibits a significative activity alone and a synergistic effect with vitamin D3 on the differentiation of U937 leukemic cell line.
Winum
J Y
JY
Laboratoire de Chimie Biomoléculaire, associé CNRS, Université Montpellier II, France.
Kamal
M
M
Defacque
H
H
Commes
T
T
Chavis
C
C
Lucas
M
M
Marti
J
J
Montero
J L
JL
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002454:Cell Differentiation / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D009113:Muramidase / Q000378:metabolism; D010587:Phagocytosis / Q000187:drug effects; D014212:Tretinoin / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D014212:Tretinoin; D009113:Muramidase