title: Replication of feline syncytial virus in feline T-lymphoblastoid cells and induction of apoptosis in the cells.
abstract: Feline syncytial virus (FSV) was isolated from feline peripheral blood mononuclear cells of FSV-seropositive cats. When the susceptibility of feline T-lymphocytes to FSV was examined using three strains of FSV, FSV antigens were detected in the FSV-infected T-lymphoblastoid cells. Further, a diversity of biological properties, including replication kinetics and syncytia formation, was noted among the strains, and condensation of chromatin and the fragmentation of cellular DNA were observed in the infected cells. From these data, we conclude that FSV is lymphotropic and can induce apoptosis in the lymphocytes.
authors.affiliation: Department of Veterinary Microbiology, University of Tokyo, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Ikeda
authors.forename: S
authors.initials: S
authors.lastname: Itagaki
authors.forename: S
authors.initials: S
authors.lastname: Tsutsui
authors.forename: Y
authors.initials: Y
authors.lastname: Inoshima
authors.forename: M
authors.initials: M
authors.lastname: Fukasawa
authors.forename: K
authors.initials: K
authors.lastname: Tomonaga
authors.forename: Y
authors.initials: Y
authors.lastname: Tohya
authors.forename: K
authors.initials: K
authors.lastname: Maeda
authors.forename: M
authors.initials: M
authors.lastname: Mochizuki
authors.forename: T
authors.initials: T
authors.lastname: Miyazawa
authors.forename: T
authors.initials: T
authors.lastname: Mikami
mesh_terms: D000818:Animals; D000956:Antigens, Viral / Q000032:analysis; D017209:Apoptosis; D002415:Cats; D002460:Cell Line; D053938:DNA Fragmentation; D016092:Spumavirus / Q000276:immunology / Q000502:physiology*; D013601:T-Lymphocytes / Q000166:cytology / Q000821:virology*; D014407:Tumor Cells, Cultured; D014779:Virus Replication
chemical_list: D000956:Antigens, Viral