title: Glottic cancer with subglottic extension.
abstract: The outcomes of 27 patients with glottic cancer extending into the subglottis (GCSE) who were treated by surgery and radiation (n = 17) or radiation alone (n = 10) during a 13-year period were retrospectively reviewed. Since this study was nonrandomized and retrospective, the patient groups were not equally matched with regard to age (p > 0.05), gender (p > 0.30), or disease stage (p > 0.05). The locoregional failure rate was 18 +/- [95% CI] 20% in patients who received combined therapy and 40 +/- 31% in persons treated by radiation alone (p = 0.20); the corresponding survival rates at two years were 53 +/- 24% and 42 +/- 31% (p > 0.50). These findings suggest that GCSE may be better managed by a combination of surgery and radiotherapy than by the use of radiotherapy alone.
authors.affiliation: Department of Radiology, Louisiana State University School of Medicine, Shreveport 71130, USA.
authors.forename: F L
authors.initials: FL
authors.lastname: Ampil
authors.forename: C A
authors.initials: CA
authors.lastname: Menezes
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016009:Chi-Square Distribution; D003131:Combined Modality Therapy; D005260:Female; D005931:Glottis / Q000473:pathology*; D006801:Humans; D007822:Laryngeal Neoplasms / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D011829:Radiation Dosage; D012189:Retrospective Studies; D015996:Survival Rate; D016896:Treatment Outcome