title: Gastric uptake during Re-186 HEDP bone scintigraphy.
abstract: In bone scintigraphy extraosseous uptake of the radiopharmaceutical (TcO4-, pertechnetate) is a common finding when the stomach is abnormally observed; this may be due to the instability of the radiopharmaceutical leading to free pertechnetate within this organ. The same explanation might be inculpate rhenium 186-HEDP, due to its similarity to Tc-99m MDP's sphysicochemical properties and behavior, as both radioisotopes are Group VII metals /1/ and are labelling the same ligand (a diphosphonate moiety). We report on 186Re-HEDP uptake in the stomach in two patients with osseous metastases because of prostate and breast cancer respectively out of a series of 52 cancer affected individuals, treated with 186Re-HEDP. The thorough clinical and laboratory investigation of both patients assessed that this extraosseous radio-rhenium accumulation was multifactorial with the main cause being a disturbance of body fluid acid-balance, favoring calcium and phosphate ion precipitation and leading to 186Re-HEDP extraosseous uptake.
authors.affiliation: Department of Radiology, Areteion University Hospital, Athens University Medical School, Greece.
authors.forename: G S
authors.initials: GS
authors.lastname: Limouris
authors.forename: S K
authors.initials: SK
authors.lastname: Skukla
mesh_terms: D001859:Bone Neoplasms / Q000000981:diagnostic imaging / Q000378:metabolism*; D001842:Bone and Bones / Q000000981:diagnostic imaging* / Q000378:metabolism; D001943:Breast Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000532:radiotherapy*; D012968:Etidronic Acid / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D009942:Organometallic Compounds; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000532:radiotherapy*; D019275:Radiopharmaceuticals; D012211:Rhenium / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D013270:Stomach / Q000000981:diagnostic imaging*; D013669:Technetium Tc 99m Medronate; D014055:Tomography, Emission-Computed
chemical_list: D009942:Organometallic Compounds; D019275:Radiopharmaceuticals; C101598:rhenium-186 HEDP; D012211:Rhenium; D012968:Etidronic Acid; D013669:Technetium Tc 99m Medronate