title: Biological studies of Bolax gummifera, a plant of the Falkland Islands used as a treatment of wounds.
abstract: Aqueous and dichloromethane extracts of Bolax gummifera (Lam.) Sprengel (Apiaceae), a plant of the Falkland Islands used as a treatment of wounds, were studied in order to support the ethnopharmacological information related to the medicinal use of this plant. The antimicrobial, antioxidant and red blood cells membrane stabilizing activities were analyzed. The antimicrobial bioassay was carried out using the test turbidity method (OD 620 nm), the aqueous extract showing an 82% inhibition of Staphylococcus aureus but no activity against Pseudomonas aeruginosa. The dichloromethane extract inhibited both microorganisms: S. aureus in 94% and P. aeruginosa in 32%. No antioxidant activity could be observed using hydroperoxide-initiated chemiluminescence in rat liver homogenates. Investigations into the membrane stabilizing activity of the extracts were carried out using human red blood cells subjected to hypotonic- and heat-induced lyses. The aqueous extract showed an important stabilizing activity of the red blood cell membrane.
authors.affiliation: Catedra de Microbiologia Industrial y Biotecnologia, Facultad de Farmacia v Bioquimica, Universidad de Buenas Aires, Argentina.
authors.forename: E
authors.initials: E
authors.lastname: Mongelli
authors.forename: C
authors.initials: C
authors.lastname: Desmarchelier
authors.forename: J
authors.initials: J
authors.lastname: Coussio
authors.forename: G
authors.initials: G
authors.lastname: Ciccia
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology*; D004910:Erythrocyte Membrane / Q000187:drug effects* / Q000473:pathology; D019432:Falkland Islands; D006358:Hot Temperature / Q000009:adverse effects; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008163:Luminescent Measurements; D008519:Medicine, Traditional; D008752:Methylene Chloride / Q000737:chemistry; D008826:Microbial Sensitivity Tests; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000378:metabolism; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D013211:Staphylococcus aureus / Q000187:drug effects; D014867:Water / Q000737:chemistry; D014945:Wound Healing / Q000187:drug effects*; D014946:Wound Infection / Q000517:prevention & control; D014947:Wounds and Injuries / Q000628:therapy*
chemical_list: D000900:Anti-Bacterial Agents; D000975:Antioxidants; D010936:Plant Extracts; D014867:Water; D008752:Methylene Chloride