title: 99mTc-MIBI prone scintimammography in patients with high and intermediate risk mammography.
abstract: Mammographic lesions can be classified into categories of high (HR), intermediate (IR) and low risk of breast cancer. We have performed 99mTc MIBI scintimammography on 85 patients with high or intermediate risk lesions in order to verify its ability to diagnose cancer before biopsy. The scintimammography was performed in prone lateral view; all the patients were submitted to excisional biopsy. HR lesions showed 86% of cancers and scintigraphic accuracy of 0.81. The accuracy of scintimammography was 0.97 in lesions larger than 1 cm. IR lesions showed 47% of cancer with scintigraphic accuracy of 0.95. The scintigraphic sensitivity was 0.97 lesions larger than and 0.50 in lesion smaller than 1 cm, whereas the specificity was always about 90%. Our results suggest that scintimammography can substantially decrease the need of biopsy for breast cancer diagnosis.
authors.affiliation: Department of Experimental Medicine, University La Sapienza, Rome, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Scopinaro
authors.forename: M
authors.initials: M
authors.lastname: Ierardi
authors.forename: L M
authors.initials: LM
authors.lastname: Porfiri
authors.forename: N S
authors.initials: NS
authors.lastname: Tiberio
authors.forename: G
authors.initials: G
authors.lastname: De Vincentis
authors.forename: S
authors.initials: S
authors.lastname: Mezi
authors.forename: P
authors.initials: P
authors.lastname: Cannas
authors.forename: T
authors.initials: T
authors.lastname: Gigliotti
authors.forename: L
authors.initials: L
authors.lastname: Marzetti
mesh_terms: D000328:Adult; D000368:Aged; D001706:Biopsy; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D018270:Carcinoma, Ductal, Breast / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D005188:False Negative Reactions; D005260:Female; D006801:Humans; D008327:Mammography; D008875:Middle Aged; D011237:Predictive Value of Tests; D011877:Radionuclide Imaging; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D017256:Technetium Tc 99m Sestamibi; D016217:Ultrasonography, Mammary
chemical_list: D017256:Technetium Tc 99m Sestamibi