Comparison of iodinated contrast media-induced renal vasoconstriction in human, rabbit, dog, and pig arteries.
OBJECTIVE
Contrast media (CM)-induced renal vasoconstriction is an important factor in the pathogenesis of CM-induced nephrotoxicity. The effects of ionic, high-osmolar CM sodium/meglumine diatrizoate and nonionic, low-osmolar CM iohexol and iopamidol were studied in rabbit, dog, and pig renal arteries and compared with human tissue in an organ bath.


METHODS
Isometric contractions were induced by increasing concentrations of CM and high-osmolar glucose solution.


RESULTS
Contrast media and glucose elicited contractions in human renal arteries of 32% (diatrizoate), 20% (iohexol), 30% (iopamidol), and 22% (glucose). Rabbit and dog renal arteries demonstrated contractions of 30% and 46% (diatrizoate), 15% and 23% (iohexol), 15% and 26% (iopamidol), and 11% and 40% (glucose), respectively, of the control. There was a vasorelaxing effect of all CM tested on pig renal artery.


CONCLUSIONS
Responses in rabbit and dog renal arteries were similar to those in human renal arteries and could serve as models for investigating CM-induced renal vasoconstriction.
Rauch
D
D
Department of Surgery, University of Wisconsin School of Medicine, Madison, USA.
Drescher
P
P
Pereira
F J
FJ
Knes
J M
JM
Will
J A
JA
Madsen
P O
PO
D000818:Animals; D003287:Contrast Media / Q000633:toxicity*; D003973:Diatrizoate / Q000633:toxicity; D004285:Dogs; D005947:Glucose / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D007472:Iohexol / Q000633:toxicity; D007479:Iopamidol / Q000633:toxicity; D009119:Muscle Contraction / Q000187:drug effects; D009126:Muscle Relaxation / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects* / Q000502:physiology; D011817:Rabbits; D012077:Renal Artery / Q000187:drug effects* / Q000502:physiology; D013552:Swine; D014661:Vasoconstriction / Q000187:drug effects*
D003287:Contrast Media; D003973:Diatrizoate; D007472:Iohexol; D005947:Glucose; D007479:Iopamidol