Detection of drugs and poisons in postmortem tissues--determination of paraquat in tissues of rabbits buried underground.
The possibility of detecting paraquat in tissues of rabbits buried underground over a 2-year period was examined. Paraquat (1.2 g) was given orally to rabbits, which were sacrificed 1 h after administration. The animals were buried underground, and the skeletal muscles and the bones were collected 3 and 6 months after death, and 3, 6, 12, and 24 months after death, respectively. Paraquat was present in all bone marrow samples, showing a slight decrease in concentration until 12 months. Paraquat was also detected in all skeletal muscle samples, showing almost no change in concentration until 6 months. These results indicate that intoxication with paraquat as well as the degree of poisoning can both be determined from the skeletal muscles and bone marrow of cadavers which have been buried underground for a long period of time even in human cases.
Ito
S
S
Department of Forensic Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Kudo
K
K
Imamura
T
T
Jitsufuchi
N
N
Kimura
K
K
D000818:Animals; D001853:Bone Marrow / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D005554:Forensic Medicine; D006801:Humans; D018482:Muscle, Skeletal / Q000737:chemistry*; D010269:Paraquat / Q000032:analysis* / Q000493:pharmacokinetics / Q000506:poisoning; D011180:Postmortem Changes; D011817:Rabbits; D013997:Time Factors; D014018:Tissue Distribution
D010269:Paraquat