Immunohistochemistry with monoclonal antibody against Candida albicans mannan antigen demonstrates cutaneous Candida granulomas as evidence of Candida sepsis in an immunosuppressed host.
We report the occurrence of invasive Candida albicans infection with disseminated cutaneous Candida granulomas in a patient with aplastic anaemia after viral hepatitis. Fungal elements in a skin biopsy specimen were detected by PAS stain and identified as Candida sp. by immunohistochemistry directed against the C. albicans mannan surface antigen. Based on rapid diagnosis of Candida granuloma and by Candida-positive cultures of blood and swabs, systemic treatment with liposomal amphotericin B led to survival of the patient.
Breier
F
F
Department of Dermatology, University Clinic for Internal Medicine IV, Vienna, Austria.
Oesterreicher
C
C
Brugger
S
S
Linkesch
W
W
Anegg
B
B
Jurecka
W
W
D000328:Adult; D000666:Amphotericin B / Q000627:therapeutic use; D000741:Anemia, Aplastic / Q000821:virology; D000908:Antibodies, Fungal; D000911:Antibodies, Monoclonal; D000935:Antifungal Agents / Q000627:therapeutic use; D000946:Antigens, Fungal / Q000032:analysis*; D000954:Antigens, Surface / Q000032:analysis; D002176:Candida albicans / Q000276:immunology*; D002177:Candidiasis / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D003881:Dermatomycoses / Q000175:diagnosis* / Q000473:pathology; D006099:Granuloma / Q000175:diagnosis / Q000382:microbiology* / Q000473:pathology; D006525:Hepatitis, Viral, Human; D006566:Herpesviridae Infections; D004854:Herpesvirus 4, Human; D006801:Humans; D016867:Immunocompromised Host; D007150:Immunohistochemistry; D008297:Male; D008351:Mannans / Q000032:analysis*; D011135:Polysaccharides, Bacterial / Q000032:analysis*; D018805:Sepsis / Q000175:diagnosis* / Q000188:drug therapy
D000908:Antibodies, Fungal; D000911:Antibodies, Monoclonal; D000935:Antifungal Agents; D000946:Antigens, Fungal; D000954:Antigens, Surface; D008351:Mannans; D011135:Polysaccharides, Bacterial; D000666:Amphotericin B