Construction of double-helical DNA structures based on dinucleotide building blocks.
We present a new method for building full 3-D structures of DNA sequences. A database of the conformational properties of dinucleotide steps has been compiled using X-ray crystal structures of oligonucleotides. The protocol uses these dinucleotides as building blocks to generate three dimensional structures of any required sequence in any required conformation.
Hunter
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CA
Krebs Institute for Biomolecular Science, Department of Chemistry, University of Sheffield, UK. C.Hunter@Sheffield.ac.uk
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D018360:Crystallography, X-Ray; D004247:DNA / Q000138:chemical synthesis / Q000737:chemistry*; D016208:Databases, Factual; D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D009838:Oligodeoxyribonucleotides / Q000737:chemistry
D009838:Oligodeoxyribonucleotides; D004247:DNA