[Surface-active substances in the arsenal of agents against AIDS].
Only nucleoside analogues such as zidovudine have been widely used to improve the clinical state of patients with AIDS till now. Their use has a number of eliminations. Nevertheless, the anti-HIV properties of many different substances have been shown. Some of them contain hydrophobic and polar parts of molecules and can be considered as surfactants. Detergents (DT) (among them Ukrainian preparation Myramistin), modified phospholipids, polyene antibiotics (such as Nystatin A), lipophilic muramyl peptides (LMP), saponins (S) and some other surfactants have been described as inhibitors of HIV replication. Moreover, LMP and S are the potent adjuvants and are probable candidates for vaccines against HIV. Adjuvant activities of some DT have been shown recently as well. We hope that elaboration of new adjuvants with strong anti-HIV properties is an attractive and manageable aim.
Krivoshein
Iu S
IuS
Krivorutchenko
Iu L
IuL
D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy* / Q000517:prevention & control; D019380:Anti-HIV Agents / Q000494:pharmacology / Q000627:therapeutic use*; D015497:HIV-1 / Q000187:drug effects; D006801:Humans; D012503:Saponins / Q000494:pharmacology / Q000627:therapeutic use; D013501:Surface-Active Agents / Q000494:pharmacology / Q000627:therapeutic use*
D019380:Anti-HIV Agents; D012503:Saponins; D013501:Surface-Active Agents