title: Nematocidal efficacy of eprinomectin, delivered topically, in naturally infected cattle.
abstract: OBJECTIVE
  To assess the nematocidal efficacy of eprinomectin in naturally infected cattle.
  
  
  METHODS
  62 (31 eprinomectin-treated and 31 control) beef mixed-breed or Holstein cattle, either 6 to 11 or 48 to 96 months old.
  
  
  METHODS
  Cattle were housed 21 to 27 days before treatment to allow parasites to reach maturity. Animals were grouped by sex, ranked by weight, and randomly assigned to treatment group. Fecal flotation was done to identify cattle with intestinal nematode infections. Treatment groups were: 1--eprinomectin topical vehicle (1 ml/10 kg) and 2--eprinomectin topical solution (1 ml/10 kg). Cattle were euthanatized by replicate on day 14 or 15, and standard procedures were used to recover of pulmonary, abomasal, small intestinal, and large intestinal nematodes.
  
  
  RESULTS
  Eprinomectin efficacy across all trials was 100% against adult Trichostrongylus axei, Haemonchus placei, Oesophagostomum radiatum, and Dictyocaulus viviparus, as well a fourth-stage larval Oes radiatum, Ostertagia ostertagi, Nematodirus helvetianus, and Cooperia spp. Efficacy against adult O ostertagi, Cooperia oncophora, C punctata, C surnabada, C spatulata, N helvetianus, Trichuris sp, and Trichuris fourth-stage larvae was 99.9 and 99.8, 99.6, 98.9, 98.3, 99.7, 97.8, and 84.3%, respectively. All results were significant (P < 0.01) except those for C spatulata. Adverse reactions were not observed.
  
  
  CONCLUSIONS
  Eprinomectin is a safe and effective nematocide against naturally acquired nematode infections in cattle when administered at a dosage of 500 micrograms/kg. Milk and meat withholding is not necessary when using this product.
authors.affiliation: Department of Animal Sciences, University of Arkansas, Fayetteville 72701, USA.
authors.forename: T A
authors.initials: TA
authors.lastname: Yazwinski
authors.forename: E G
authors.initials: EG
authors.lastname: Johnson
authors.forename: D R
authors.initials: DR
authors.lastname: Thompson
authors.forename: M D
authors.initials: MD
authors.lastname: Drag
authors.forename: G L
authors.initials: GL
authors.lastname: Zimmerman
authors.forename: W K
authors.initials: WK
authors.lastname: Langholff
authors.forename: J E
authors.initials: JE
authors.lastname: Holste
authors.forename: J S
authors.initials: JS
authors.lastname: Eagleson
mesh_terms: D000287:Administration, Topical; D000818:Animals; D000969:Antinematodal Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy* / Q000453:epidemiology; D004305:Dose-Response Relationship, Drug; D005243:Feces / Q000469:parasitology; D005260:Female; D006188:Haemonchiasis / Q000188:drug therapy / Q000453:epidemiology / Q000662:veterinary; D006189:Haemonchus / Q000302:isolation & purification; D007559:Ivermectin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D008297:Male; D009349:Nematode Infections / Q000188:drug therapy / Q000453:epidemiology / Q000662:veterinary*; D009814:Oesophagostomiasis / Q000188:drug therapy / Q000453:epidemiology / Q000662:veterinary; D009815:Oesophagostomum / Q000302:isolation & purification; D010270:Parasite Egg Count / Q000662:veterinary; D014253:Trichostrongylosis / Q000188:drug therapy / Q000453:epidemiology / Q000662:veterinary; D014254:Trichostrongylus / Q000302:isolation & purification; D014481:United States / Q000453:epidemiology
chemical_list: D000969:Antinematodal Agents; D007559:Ivermectin; C101434:eprinomectin