Non-organ specific autoantibodies against cellular components in HIV-1 infected individuals.
OBJECTIVE
To detect the presence of autoantibodies against cellular components in HIV-1 infected individuals.


METHODS
Serum samples from 87 patients with HIV-1 infection and from 17 healthy HIV-seronegative controls were tested using sensitive and specific techniques (immunoblot, RNA precipitation), as well as counterimmunoelectrophoresis and indirect immunofluorescence.


RESULTS
Four sera (4.6%) showed reactivity in immunoblot against various unidentified cytoplasmic autoantigens. The four positive sera were obtained from patients belonging in equal numbers to the non-AIDS and AIDS groups.


CONCLUSIONS
It appears that the production of antibodies against cellular components rarely occurs during the clinical course of HIV infection.
Kordossis
T
T
Department of Pathophysiology, Medical School of Athens, Greece.
Piha
L
L
Guialis
A
A
Kosmopoulou
O
O
Tzioufas
A G
AG
Moutsopoulos
H M
HM
D000163:Acquired Immunodeficiency Syndrome / Q000097:blood / Q000145:classification / Q000276:immunology; D000328:Adult; D000918:Antibody Specificity; D001323:Autoantibodies / Q000276:immunology*; D001324:Autoantigens / Q000097:blood / Q000276:immunology; D015153:Blotting, Western; D003378:Counterimmunoelectrophoresis; D003593:Cytoplasm / Q000276:immunology / Q000821:virology; D005260:Female; D019085:Fluorescent Antibody Technique, Direct; D015658:HIV Infections / Q000276:immunology* / Q000473:pathology; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011233:Precipitin Tests; D011506:Proteins / Q000276:immunology / Q000378:metabolism; D012313:RNA / Q000097:blood / Q000276:immunology; D013194:Staining and Labeling
D001323:Autoantibodies; D001324:Autoantigens; D011506:Proteins; D012313:RNA