title: [Survival in stage T2-T3A bladder cancer treated with radical cystectomy].
abstract: OBJECTIVE
  The optimal treatment for patients with localized muscle-infiltrating urothelial carcinoma (Jewett stage B or T2-T3a of the TNM classification, UICC 1992) continues to be a controversy. The present study analyzed the survival rate in patients with stage T2-T3a bladder cancer who had been treated by radical cystectomy.
  
  
  METHODS
  The records of 50 patients with T2-T3a NO tumor, submitted to pelvic lymphadenectomy and radical cystoprostatectomy, were reviewed to determine the prognosis in this group of patients. Seventeen patients (34%) received three courses of systemic chemotherapy (CMV) prior to cystectomy.
  
  
  RESULTS
  The overall 5-year survival rate was 73%; 76% for those with T2 (n = 30) and 67% for those with T3a (n = 20) (log-rank, p = 0.27). No statistically significant differences were observed for age (less than or over 65 years), tumor growth pattern (papillary or flat), tumor size (less or greater than 5 cms) or treatment (with or without induction CMV). However, patients with G1-2 tumor had a better survival rate (94% at 5 years) than those with G3 tumor (51%), a difference with statistical significance (log-rank, p = 0.047). The Cox regression analysis showed no independent variable of prognostic significance.
  
  
  CONCLUSIONS
  Muscle-infiltrating urothelial carcinoma is highly curable by radical surgery. Some authors believe it is unnecessary to distinguish T2-T3a lesions; therefore a critical review of the TNM classification appears to be warranted. We are unable to distinguish patients with a better prognosis that might benefit from less aggressive therapeutic options. Similarly, the therapeutic benefits of induction chemotherapy prior to cystectomy in patients with stage T2-T3a tumor could not be demonstrated.
authors.affiliation: Servicio de Urología, Hospital Príncipe de Asturias, Alcalá de Henares, Madrid, España.
authors.forename: J
authors.initials: J
authors.lastname: Angulo Cuesta
authors.forename: M
authors.initials: M
authors.lastname: Sánchez Chapado
authors.forename: M
authors.initials: M
authors.lastname: Guil Cid
authors.forename: N
authors.initials: N
authors.lastname: Flores Corral
authors.forename: E J
authors.initials: EJ
authors.lastname: Pontes
authors.forename: D J
authors.initials: DJ
authors.lastname: Grignon
mesh_terms: D000368:Aged; D015653:Cystectomy; D006801:Humans; D009367:Neoplasm Staging; D011379:Prognosis; D015996:Survival Rate; D001749:Urinary Bladder Neoplasms / Q000401:mortality* / Q000473:pathology / Q000601:surgery*