Melatonin administration protects CA1 hippocampal neurons after transient forebrain ischemia in rats.
Melatonin administered at the beginning of cerebral reperfusion protected CA1 neurons against 10, 20 and 30 min of transient forebrain ischemia. Intraperitoneal injections of saline or melatonin (10 mg/kg) were given after 0, 2 and 6 h, or 1, 2 and 6 h of cerebral reperfusion, or 30 min prior to ischemia. One week later, quantitative histological analysis demonstrated that CA1 neuronal density was significantly increased in the melatonin groups that were treated at 0, 2, 6 h compared to the saline-treated controls. Ischemic protection of CA1 was lost in the animals in which the melatonin treatment was delayed by 1 h, or given 30 min prior to the ischemia.
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Laboratory of Molecular Biology, Cornell University Medical College at The Burke Medical Research Institute, White Plains, NY 10605, USA.
Joh
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Baik
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Dibinis
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Volpe
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D000704:Analysis of Variance; D000818:Animals; D016166:Free Radical Scavengers; D006624:Hippocampus / Q000166:cytology / Q000187:drug effects*; D002546:Ischemic Attack, Transient / Q000188:drug therapy*; D008297:Male; D008550:Melatonin / Q000627:therapeutic use*; D009474:Neurons / Q000187:drug effects; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D016548:Prosencephalon / Q000098:blood supply*; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000517:prevention & control
D016166:Free Radical Scavengers; D018696:Neuroprotective Agents; D008550:Melatonin