Mouse embryos in culture: models for understanding diabetes-induced embryopathies and gene function.
Both the metabolic studies on diabetes and the genetic studies using antisense oligodeoxynucleotides clearly demonstrate the importance and usefulness of rodent whole embryo culture. Without this technique, these studies would be impossible and, consequently, our knowledge of both normal and abnormal development would not be as advanced as it is today. The culture system fills a unique niche in studies in the fields of developmental biology and teratology and these sciences would have been less well served without Dr. New's contribution.
Sadler
T W
TW
University of North Carolina, Department of Cell Biology and Anatomy, UNC Birth Defects Center, Chapel Hill 27599, USA. tsadler@med.unc.edu
D020155:3-Hydroxybutyric Acid; D000818:Animals; D046508:Culture Techniques; D004195:Disease Models, Animal; D005314:Embryonic and Fetal Development; D005260:Female; D005315:Fetal Diseases / Q000209:etiology*; D018390:Gene Targeting; D006885:Hydroxybutyrates / Q000633:toxicity; D051379:Mice; D016376:Oligonucleotides, Antisense; D011247:Pregnancy; D011254:Pregnancy in Diabetics
D006885:Hydroxybutyrates; D016376:Oligonucleotides, Antisense; D020155:3-Hydroxybutyric Acid