title: Chromosomal localization of the adrenoleukodystrophy-related gene in man and mice.
abstract: We report here on the chromosomal mapping of the adrenoleukodystrophy-related (ALDR) gene on both the human and the mouse genomes. This gene encodes a peroxisomal ATP binding cassette transporter, closely related to the transporter identified as responsible for the adrenoleukodystrophy phenotype. ALDR maps on the syntenic region on murine and human autosomes. In addition, we could determine its position in relation to known microsatellite framework markers; this will allow to test its role in Zellweger syndrome and/ or related peroxisomal disorders.
authors.affiliation: Centre d'Immunologie INSERM-CNRS de Marseille-Luminy, France.
authors.forename: S
authors.initials: S
authors.lastname: Savary
authors.forename: N
authors.initials: N
authors.lastname: Troffer-Charlier
authors.forename: G
authors.initials: G
authors.lastname: Gyapay
authors.forename: M G
authors.initials: MG
authors.lastname: Mattei
authors.forename: G
authors.initials: G
authors.lastname: Chimini
mesh_terms: D000074061:ATP Binding Cassette Transporter, Subfamily D; D018528:ATP-Binding Cassette Transporters; D000326:Adrenoleukodystrophy / Q000235:genetics*; D000818:Animals; D002874:Chromosome Mapping; D002875:Chromosomes / Q000235:genetics; D002881:Chromosomes, Human, Pair 12 / Q000235:genetics; D006801:Humans; D017403:In Situ Hybridization; D008565:Membrane Proteins / Q000235:genetics; D051379:Mice; D018901:Peroxisomal Disorders / Q000235:genetics; D011506:Proteins / Q000235:genetics*; D015211:Zellweger Syndrome / Q000235:genetics
chemical_list: C431694:ABCD2 protein, human; C063305:ABCD3 protein, human; D000074061:ATP Binding Cassette Transporter, Subfamily D; D018528:ATP-Binding Cassette Transporters; C489271:Abcd3 protein, mouse; D008565:Membrane Proteins; D011506:Proteins