Etiology of (CAG)n triplet repeat neurodegenerative diseases such as Huntington's disease is connected to stimulation of glutamate receptors.
Chronic neurodegenerative diseases with expanded, genetically unstable (CAG)n triplet repeats include Huntington's disease. It is hypothesized that pathology results from excessive stimulation of glutamate receptors by glutamine.
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D015551:Autoimmunity; D002561:Cerebrovascular Disorders / Q000378:metabolism; D004827:Epilepsy / Q000378:metabolism; D018698:Glutamic Acid / Q000378:metabolism; D006801:Humans; D006816:Huntington Disease / Q000209:etiology* / Q000235:genetics* / Q000378:metabolism; D018598:Minisatellite Repeats; D008954:Models, Biological; D009410:Nerve Degeneration / Q000235:genetics / Q000502:physiology; D017470:Receptors, Glutamate / Q000378:metabolism*; D018911:Trinucleotide Repeats
D017470:Receptors, Glutamate; D018698:Glutamic Acid