title: Pregnancy and birth after intracytoplasmic sperm injection with totally immotile sperm recovered from the ejaculate.
abstract: OBJECTIVE
  To report the birth of two healthy children after intracytoplasmic sperm injection (ICSI) with totally immotile spermatozoa recovered from the ejaculate.
  
  
  METHODS
  Retrospective case report.
  
  
  METHODS
  University-based hospital.
  
  
  METHODS
  Four couples in whom spermatozoa recovered from the ejaculate were totally immotile but presented normal vitality scores.
  
  
  METHODS
  Therapeutical IVF-ET attempts coupled with ICSI.
  
  
  METHODS
  Fertilization and pregnancy results after ICSI.
  
  
  RESULTS
  With random sperm injection, 19 of the 36 injected oocytes showed normal fertilization and cleavage. One of four patients had a twin pregnancy that resulted in birth of two healthy children.
  
  
  CONCLUSIONS
  In cases in which totally immotile ejaculated sperm present normal vitality scores, normal clinical outcomes can be achieved by using the usual random sperm selection during conventional ICSI.
authors.affiliation: Laboratory of Medical Genetics, Faculty of Medicine, University of Porto, Portugal.
authors.forename: A
authors.initials: A
authors.lastname: Barros
authors.forename: M
authors.initials: M
authors.lastname: Sousa
authors.forename: C
authors.initials: C
authors.lastname: Oliveira
authors.forename: J
authors.initials: J
authors.lastname: Silva
authors.forename: V
authors.initials: V
authors.lastname: Almeida
authors.forename: J
authors.initials: J
authors.lastname: Beires
mesh_terms: D000022:Abortion, Spontaneous; D000328:Adult; D003593:Cytoplasm; D004542:Ejaculation; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods*; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D012189:Retrospective Studies; D013081:Sperm Motility; D013094:Spermatozoa / Q000637:transplantation*; D014429:Twins, Dizygotic