Regulation of oligodendrocyte cell survival and differentiation by ciliary neurotrophic factor, leukemia inhibitory factor, oncostatin M, and interleukin-6.
The regulation and maintenance of developmental lineages by trophic factors, both cell-mediated and soluble, is a key aspect of cellular differentiation in the nervous system. In this review we focus on oligodendrocytes and their progenitors and how differentiation and survival are regulated by four neuropoietic cytokines: ciliary neurotrophic factor, leukemia inhibitory factor, oncostatin M, and interleukin-6 (IL-6). We discuss how these cytokines act as "broad spectrum" factors. That is, how, even within a specific cell lineage, a given cytokine may have different effects on the target cells at various stages of differentiation.
Vos
J P
JP
Department of Microbiology, University of Connecticut Medical School, Farmington, USA.
Gard
A L
AL
Pfeiffer
S E
SE
D000818:Animals; D002454:Cell Differentiation; D002470:Cell Survival; D020934:Ciliary Neurotrophic Factor; D016207:Cytokines / Q000502:physiology; D006131:Growth Inhibitors / Q000502:physiology*; D006801:Humans; D015850:Interleukin-6 / Q000502:physiology*; D053605:Leukemia Inhibitory Factor; D008222:Lymphokines / Q000502:physiology*; D008959:Models, Neurological; D009414:Nerve Growth Factors / Q000502:physiology; D009419:Nerve Tissue Proteins / Q000502:physiology*; D009420:Nervous System / Q000166:cytology; D009424:Nervous System Physiological Phenomena; D009836:Oligodendroglia / Q000166:cytology* / Q000502:physiology; D053683:Oncostatin M; D010455:Peptides / Q000502:physiology*; D013234:Stem Cells / Q000166:cytology / Q000502:physiology
D020934:Ciliary Neurotrophic Factor; D016207:Cytokines; D006131:Growth Inhibitors; D015850:Interleukin-6; C507837:LIF protein, human; D053605:Leukemia Inhibitory Factor; D008222:Lymphokines; D009414:Nerve Growth Factors; D009419:Nerve Tissue Proteins; C508351:OSM protein, human; D010455:Peptides; D053683:Oncostatin M