[The anti-ulcer action of zinc sulfate in models of acute and chronic ulcerogenesis in the rat duodenum].
The 5-day pretreatment of rats with zinc sulfate (50 or 150 mg/kg/day per os) significantly reduce the rate, the number, and area of cystamine-induced duodenal lesions in rats. Pretreatment with zinc sulfate in a dose of 15 mg/kg/day over a 5-day period or single administration of zinc sulfate (50 mg/kg) did not markedly reduce the above-mentioned lesion parameters. The administration of zinc sulfate (50 or 150 mg/kg/day per os) during 7 days results in a dose-dependent, significant decrease in the area of chronic acetate-induced gastric and duodenal lesions in rats. The results of clinical and experimental study indicate that zinc-containing compounds can be successfully used both for prophylaxis and treatment of duodenal ulcer.
Trapkov
V A
VA
Gobedzhashvili
O D
OD
Erzinkian
K L
KL
D019342:Acetic Acid; D000208:Acute Disease; D000818:Animals; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D002908:Chronic Disease; D003543:Cysteamine; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004381:Duodenal Ulcer / Q000139:chemically induced / Q000188:drug therapy*; D005260:Female; D008297:Male; D051381:Rats; D019287:Zinc Sulfate / Q000627:therapeutic use*
D000897:Anti-Ulcer Agents; D003543:Cysteamine; D019287:Zinc Sulfate; D019342:Acetic Acid