title: Fluorine-18-FDG PET and iodine-123-IMT SPECT in the evaluation of brain tumors.
abstract: The high glucose utilization of normal gray matter limits the detection of brain tumor tissue by PET using 18F-fluorodeoxyglucose (FDG). The aim of this study was to evaluate whether the examination of amino acid transport with the SPECT tracer 123l-alpha-methyl-L-tyrosine (IMT) allows better identification of tumor tissue than FDG-PET.
  
  
  METHODS
  Nineteen patients (16 with gliomas, 3 with nontumorous lesions) were included in the study. Two independent observers classified PET and SPECT images as positive or negative for tumor tissue and defined the extent of tumor with regions of interest. Tracer uptake of FDG and IMT was quantified by calculating the tumor uptake relative to contralateral gray and white matter.
  
  
  RESULTS
  SPECT studies were interpreted concordantly in 18 patients (kappa = 0.77) and all tumors were identified by both observers. PET studies were interpreted discordantly in 4 patients (kappa = 0.52) and only 10 tumors were identified by both observers, interobserver variability in definition of tumor extent was significantly lower in the IMT-SPECT than in the FDG-PET studies (p = 0.03). Mean tumor uptake relative to gray and white matter was 1.93 +/- 0.42 and 2.25 +/- 0.46 for IMT and 0.93 +/- 0.32 and 1.61 +/- 0.52 for FDG. All tumor uptake ratios were significantly (p < 0.01) higher for IMT than FDG, even when only glioblastomas were analyzed. No significant correlation was observed between the various uptake ratios of FDG and IMT.
  
  
  CONCLUSIONS
  Despite the lower resolution and lower sensitivity of SPECT compared with PET, IMT-SPECT was clearly superior to FDG-PET in the detection and delineation of tumor tissue.
authors.affiliation: Department of Nuclear Medicine, Klinikum Rechts der Isar, Germany.
authors.forename: W
authors.initials: W
authors.lastname: Weber
authors.forename: P
authors.initials: P
authors.lastname: Bartenstein
authors.forename: M W
authors.initials: MW
authors.lastname: Gross
authors.forename: D
authors.initials: D
authors.lastname: Kinzel
authors.forename: H
authors.initials: H
authors.lastname: Daschner
authors.forename: H J
authors.initials: HJ
authors.lastname: Feldmann
authors.forename: G
authors.initials: G
authors.lastname: Reidel
authors.forename: S I
authors.initials: SI
authors.lastname: Ziegler
authors.forename: C
authors.initials: C
authors.lastname: Lumenta
authors.forename: M
authors.initials: M
authors.lastname: Molls
authors.forename: M
authors.initials: M
authors.lastname: Schwaiger
mesh_terms: D001254:Astrocytoma / Q000000981:diagnostic imaging*; D001921:Brain / Q000000981:diagnostic imaging* / Q000378:metabolism; D001932:Brain Neoplasms / Q000000981:diagnostic imaging*; D003847:Deoxyglucose / Q000031:analogs & derivatives*; D005069:Evaluation Studies as Topic; D005260:Female; D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D005909:Glioblastoma / Q000000981:diagnostic imaging*; D006801:Humans; D007457:Iodine Radioisotopes; D008297:Male; D008781:Methyltyrosines; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000000981:diagnostic imaging; D012680:Sensitivity and Specificity; D014055:Tomography, Emission-Computed; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D005462:Fluorine Radioisotopes; D007457:Iodine Radioisotopes; D008781:Methyltyrosines; D019788:Fluorodeoxyglucose F18; D003847:Deoxyglucose; C030855:3-iodo-alpha-methyltyrosine