Telomere crisis in leukemia.
Previous studies on telomere dynamics in leukemia are summarized. The 'telomere crisis model' is proposed to explain the clonal evolution mechanism of cancer cells from the standpoint of telomere biology. Future trends, including the development of potential telomerase inhibitors as a new class of anti-cancer agent, are discussed.
Ishikawa
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Department of Life Science, Tokyo Institute of Technology, Yokohama, Japan. fishikaw@bio.titech.ac.jp
D004249:DNA Damage; D006801:Humans; D007938:Leukemia / Q000235:genetics*; D016615:Telomere / Q000235:genetics*