L-alpha-aminoadipate reduces glutamate release from brain tissue exposed to combined oxygen and glucose deprivation.
The effect of the glutamate analogue L-alpha-aminoadipate (alpha AA) on the release of glutamate and gamma-aminobutyric acid (GABA) from rat hippocampal slices was investigated in vitro. Oxygen/glucose deprivation caused a large release of glutamate and GABA. alpha AA added during energy deprivation reduced the glutamate release in a dose-dependent manner (56% reduction at 5 mM), whereas GABA release was unchanged. We speculate that ischemic glutamate release from the brain is mediated by a low affinity transport mechanism that is blocked by alpha AA.
Haugstad
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TS
Institute for Surgical Research, National Hospital, Rikshospitalet, University of Oslo, Norway.
Langmoen
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IA
D015074:2-Aminoadipic Acid / Q000031:analogs & derivatives / Q000494:pharmacology*; D000818:Animals; D015687:Cell Hypoxia; D005947:Glucose / Q000172:deficiency*; D018698:Glutamic Acid / Q000031:analogs & derivatives / Q000378:metabolism* / Q000494:pharmacology; D006624:Hippocampus / Q000378:metabolism* / Q000473:pathology; D008297:Male; D010100:Oxygen / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
D015074:2-Aminoadipic Acid; D018698:Glutamic Acid; D005947:Glucose; D010100:Oxygen