title: PF1092A, B and C, new nonsteroidal progesterone receptor ligands produced by Penicillium oblatum. II. Physico-chemical properties and structure elucidation.
abstract: The structures of PF1092A (1), B (2) and C (3), new nonsteroidal progesterone receptor ligands produced by Penicillium oblatum, were elucidated by spectroscopic analyses. These compounds possess an eremophilane-type sesquiterpene carbon skeleton and differ only in that 1 and 2 are different monoacetates of 3. The absolute configurations of 1-3 were determined by single crystal X-ray diffraction analysis of the 4-bromobenzoyl ester of PF1092A and by measuring the optical rotations of the acetylation products of these compounds.
authors.affiliation: Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd., Yokohama, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Tabata
authors.forename: M
authors.initials: M
authors.lastname: Hatsu
authors.forename: Y
authors.initials: Y
authors.lastname: Kurata
authors.forename: K
authors.initials: K
authors.lastname: Miyajima
authors.forename: M
authors.initials: M
authors.lastname: Tani
authors.forename: T
authors.initials: T
authors.lastname: Sasaki
authors.forename: Y
authors.initials: Y
authors.lastname: Kodama
authors.forename: T
authors.initials: T
authors.lastname: Tsuruoka
authors.forename: S
authors.initials: S
authors.lastname: Omoto
mesh_terms: D005663:Furans / Q000737:chemistry* / Q000494:pharmacology*; D015394:Molecular Structure; D009284:Naphthols / Q000737:chemistry* / Q000494:pharmacology*; D012717:Sesquiterpenes / Q000737:chemistry*
chemical_list: D005663:Furans; D009284:Naphthols; C106748:PF 1092A; C106749:PF 1092B; C106750:PF 1092C; D012717:Sesquiterpenes