Rheological changes in hypertensive patients treated with ramipril.
This study was designed to characterize blood viscosity changes in 13 patients with mild to moderate diastolic hypertension treated with ramipril monotherapy for three months. The ramipril dose was titrated from 2.5 to 20 mg daily to achieve a diastolic blood pressure of less than 90 mm Hg. All patients received a stable dose of ramipril for three months. Viscosity measurements were made at 37 degrees C with the Mettler Contraves LS-40 microviscometer. Fibrinogen was determined by the Clauss method by averaging three separately acquired plasma samples. The systolic blood pressure (mean +/- standard deviation) was lowered from 141.2 +/- 9.1 to 129.2 +/- 11.2 mm Hg (p = 0.005) and the diastolic blood pressure was lowered from 95.2 +/- 4.9 to 84.2 +/- 7.3 mm Hg (p = 0.0001). In 13 patients with mild to moderate diastolic hypertension, blood pressure reduction with ramipril was accompanied by no significant changes in blood viscosity, plasma viscosity, serum viscosity or fibrinogen.
Rosenson
R S
RS
Section of Cardiology, Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois 60612, USA.
Hafner
J M
JM
D000328:Adult; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001809:Blood Viscosity; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D017257:Ramipril / Q000627:therapeutic use*; D012212:Rheology
D000959:Antihypertensive Agents; D017257:Ramipril