title: Synthesis and biological activities of higher homologues of retinoic acid.
abstract: Homoretinoic and bishomoretinoic acid have been synthesized. Fast reaction under ultrasonic activation (Wolff rearrangement, saponification) produced compounds in high yields. Only the bishomo analogue exhibits a significative activity alone and a synergistic effect with vitamin D3 on the differentiation of U937 leukemic cell line.
authors.affiliation: Laboratoire de Chimie Biomoléculaire, associé CNRS, Université Montpellier II, France.
authors.forename: J Y
authors.initials: JY
authors.lastname: Winum
authors.forename: M
authors.initials: M
authors.lastname: Kamal
authors.forename: H
authors.initials: H
authors.lastname: Defacque
authors.forename: T
authors.initials: T
authors.lastname: Commes
authors.forename: C
authors.initials: C
authors.lastname: Chavis
authors.forename: M
authors.initials: M
authors.lastname: Lucas
authors.forename: J
authors.initials: J
authors.lastname: Marti
authors.forename: J L
authors.initials: JL
authors.lastname: Montero
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002454:Cell Differentiation / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D009113:Muramidase / Q000378:metabolism; D010587:Phagocytosis / Q000187:drug effects; D014212:Tretinoin / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D014212:Tretinoin; D009113:Muramidase