title: Behavioral effects of lead: commonalities between experimental and epidemiologic data.
abstract: Enormous effort has been focused over the last decade and a half on characterizing the behavioral effects of lead in the developing organism. While age-appropriate standardized measures of intelligence (IQ) have been the dependent variable most often used to assess lead-induced cognitive impairment in epidemiologic studies, researchers have also used a variety of other methods designed to assess specific behavioral processes sensitive to lead. Increased reaction time and poorer performance on vigilance tasks associated with increased lead body burden suggest increased distractibility and short attention span. Assessment of behavior on teachers' rating scales identified increased distractibility, impulsivity, nonpersistence, inability to follow sequences of directions, and inappropriate approach to problems as hallmarks of lead exposure. Robust deficits in learned skills such as reading, spelling, math, and word recognition have also been found. Spatial organizational perception and abilities seem particularly sensitive to lead-induced impairment. Assessment of complex tasks of learning and memory in both rats and monkeys has revealed overall deficits in function over a variety of behavioral tasks. Exploration of behavioral mechanisms responsible for these deficits identified increased distractibility perseveration, inability to inhibit inappropriate responding, and inability to change response strategy as underlying deficits. Thus, there is remarkable congruence between the epidemiologic and experimental literatures with regard to the behavioral processes identified as underlying the deficits inflicted by developmental lead exposure. However, careful behavioral analysis was required from researchers in both fields for such understanding to emerge.
authors.affiliation: Bureau of Chemical Safety, Food Directorate, Health Canada, Ottawa, Ontario, Canada. drice@bcad1.food.hwc.ca
authors.forename: D C
authors.initials: DC
authors.lastname: Rice
mesh_terms: D000818:Animals; D001519:Behavior / Q000187:drug effects*; D001522:Behavior, Animal / Q000187:drug effects*; D006801:Humans; D007360:Intelligence / Q000187:drug effects; D007855:Lead Poisoning / Q000523:psychology*; D007858:Learning / Q000187:drug effects; D008568:Memory / Q000187:drug effects; D009422:Nervous System Diseases / Q000139:chemically induced* / Q000453:epidemiology; D011597:Psychomotor Performance / Q000187:drug effects