Amelioration of oxidative stress by antioxidants and resveratrol in PC12 cells.
The goal of this study was to investigate the effect of resveratrol, an active ingredient found in grapes and other plant products, in ameliorating oxidative stress. Oxidative stress was induced by addition of Fe2+ and t-butyl hydroperoxide to the cultured PC12 cell medium. Resveratrol, vitamins C and/or E, were added to the cell culture medium during oxidative stress. The combination of resveratrol and vitamins C and/or E was more effective in protecting the cell than was any of these three antioxidants alone.
Chanvitayapongs
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Department of Pharmacology, University of Missouri, Columbia 65212, USA.
Draczynska-Lusiak
B
B
Sun
A Y
AY
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000494:pharmacology*; D016923:Cell Death / Q000187:drug effects; D015227:Lipid Peroxidation / Q000187:drug effects; D018384:Oxidative Stress / Q000187:drug effects*; D016716:PC12 Cells; D010545:Peroxides / Q000494:pharmacology; D051381:Rats; D017382:Reactive Oxygen Species; D000077185:Resveratrol; D013267:Stilbenes / Q000494:pharmacology*; D014810:Vitamin E / Q000494:pharmacology*; D020122:tert-Butylhydroperoxide
D000975:Antioxidants; D010545:Peroxides; D017382:Reactive Oxygen Species; D013267:Stilbenes; D014810:Vitamin E; D020122:tert-Butylhydroperoxide; D001205:Ascorbic Acid; D000077185:Resveratrol