Ophthalmologic examination in systemic toxicity studies: an overview.
The procedures of ophthalmologic examination used by the authors during systemic toxicity studies in laboratory animals are presented in this paper. The present international guidelines with respect to the requirements for ophthalmological examination are given in an overview. A list of proposed keywords is included which may be used in describing ocular changes.
Kuiper
B
B
Notox Safety and Environmental Research BV,'s-Hertogenbosch, The Netherlands.
Boevé
M H
MH
Jansen
T
T
Roelofs-van Emden
M E
ME
Thuring
J W
JW
Wijnands
M V
MV
D000818:Animals; D002415:Cats; D004285:Dogs; D005123:Eye / Q000187:drug effects; D005654:Fundus Oculi; D051379:Mice; D009885:Ophthalmology / Q000379:methods*; D009887:Ophthalmoscopy; D010781:Photography; D011817:Rabbits; D051381:Rats; D012016:Reference Values; D013552:Swine / Q000502:physiology; D013556:Swine, Miniature / Q000502:physiology; D013666:Tears / Q000378:metabolism; D014065:Tonometry, Ocular / Q000379:methods; D018675:Toxicity Tests / Q000379:methods*