[Blood rheological study in rats with fatty liver--with special reference to effects of ethyl icosapentate].
A blood rheological study was conducted using Kikuchi's micro-channel method in rats with fatty liver. Effects of eicosapentaenoic acid (EPA) on blood rheology were also evaluated. Male SD rats given normal feed served as the control. One group was given choline-deficient feed for 4 weeks (EPA (-) group), while another group was daily given EPA (1000 mg/kg) for 4 weeks together with choline-deficient feed (EPA (+) group). The micro-channel passage time was determined using 100 microliters of whole blood. The passage time significantly increased in the EPA (-) group compared to the control (p < 0.01). It significantly decreased in the EPA (+) group compared to the EPA (-) group (p < 0.01). Findings obtained in the present study suggested that blood rheological factors are related to the development of fatty liver and that EPA inhibits fatty changes of the liver by improving these rheological factors.
Kurihara
T
T
Aoyama Hospital.
Tsuchiya
M
M
Akimoto
M
M
Hashimoto
H
H
Ishiguro
H
H
Niimi
A
A
Maeda
A
A
Shigemoto
M
M
Yamashita
K
K
Yokoyama
I
I
Kikuchi
Y
Y
D000818:Animals; D015118:Eicosapentaenoic Acid / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005227:Fatty Acids / Q000737:chemistry; D005234:Fatty Liver / Q000188:drug therapy* / Q000503:physiopathology*; D008099:Liver / Q000473:pathology; D008102:Liver Circulation; D008297:Male; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012212:Rheology
D005227:Fatty Acids; D010975:Platelet Aggregation Inhibitors; C035276:eicosapentaenoic acid ethyl ester; D015118:Eicosapentaenoic Acid