[The toxicological characteristics of Gastrofenzin. I. Its acute toxicity (oral, subcutaneous and intravenous)].
The acute toxicity of the antiulcer drug "Gastrofenzin", synthesized in Bulgaria has been studied in oral, subcutaneous and intravenous application in white rats "Wistar" and white mice "ICR". The main toxicometric parameters (LD50, LD16, LD84 and others) have been determined. The clinical picture of intoxication is characterized mainly by symptoms deriving from in the central and vegetative nerve system. According to the parameters of acute oral toxicity (LD50 for male white rats is 665.0 mg.kg-1 and for female--876 mg.kg-1) and to the classification of Hodge & Stemer Gastrofenzin refers to the group of slightly toxic drugs. The LD50 in subcutaneous application is 938.0 mg.kg-1 for the male and 891.0 mg.kg-1 for the female rats. For the intravenous application LD50 is 50,1 mg.kg-1 for the male and 43.6 mg.kg-1 for the female rats. The coefficient of lethal intoxication danger is below 0.1 in the three ways of application which confirms its status according to the upper classification. A significant sex difference in the indicators of acute oral toxicity for the white rats and white mice has not been observed. The white mice of both sexes seem to be more sensitive to the drugs' effects than the white rats.
Khalkova
Zh
Zh
Zaĭkov
Kh
Kh
Antov
G
G
Mikhaĭlova
A
A
Ivanova
N
N
D000284:Administration, Oral; D000818:Animals; D000897:Anti-Ulcer Agents / Q000008:administration & dosage / Q000633:toxicity*; D000928:Antidepressive Agents / Q000008:administration & dosage / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D005260:Female; D007275:Injections, Intravenous; D007279:Injections, Subcutaneous; D007546:Isoquinolines / Q000008:administration & dosage / Q000633:toxicity*; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D051381:Rats; D017208:Rats, Wistar; D044005:Tetrahydroisoquinolines
D000897:Anti-Ulcer Agents; D000928:Antidepressive Agents; D007546:Isoquinolines; D044005:Tetrahydroisoquinolines; C068492:gastrofenzin