title: Quantitative anatomic measures and comorbid medical illness in late-life major depression.
abstract: The authors examined the individual and relative roles of atrophy, comorbid medical illness, and cerebrovascular risk factors in the pathogenesis of late-life major depressive disorder (MDD). They used magnetic resonance imaging techniques to study 28 subjects with late-life MDD, 29 healthy control subjects, and 34 subjects with probable dementia of the Alzheimer type (DAT). Depressed subjects showed increases in cerebrospinal fluid volumes comparable to the DAT group but significantly different from control subjects. High-intensity signals, but not measures of atrophy correlated significantly with cerebrovascular risk factor scores. A logistic regression revealed that both brain atrophy and medical illness are associated with an increased risk of developing MDD. Data suggest that both atrophy and comorbid medical illness increase the likelihood of developing MDD in late life.
authors.affiliation: Department of Psychiatry (Section of Geriatric Psychiatry), University of Pennsylvania School of Medicine, Philadelphia, USA.
authors.forename: A
authors.initials: A
authors.lastname: Kumar
authors.forename: D
authors.initials: D
authors.lastname: Miller
authors.forename: D
authors.initials: D
authors.lastname: Ewbank
authors.forename: D
authors.initials: D
authors.lastname: Yousem
authors.forename: A
authors.initials: A
authors.lastname: Newberg
authors.forename: S
authors.initials: S
authors.lastname: Samuels
authors.forename: P
authors.initials: P
authors.lastname: Cowell
authors.forename: G
authors.initials: G
authors.lastname: Gottlieb
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000175:diagnosis* / Q000453:epidemiology / Q000523:psychology; D001284:Atrophy; D001921:Brain / Q000473:pathology*; D002552:Cerebral Ventricles / Q000473:pathology; D002555:Cerebrospinal Fluid / Q000502:physiology; D002561:Cerebrovascular Disorders / Q000175:diagnosis / Q000453:epidemiology / Q000523:psychology; D015897:Comorbidity; D003866:Depressive Disorder / Q000175:diagnosis* / Q000453:epidemiology / Q000523:psychology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008609:Mental Status Schedule; D019965:Neurocognitive Disorders / Q000175:diagnosis* / Q000453:epidemiology / Q000523:psychology; D009483:Neuropsychological Tests; D012016:Reference Values