Anticarcinogenic and antimetastatic activity of Iscador.
Methylcholanthrene-induced sarcoma formation in mice was found to be effectively inhibited by the intraperitoneal injection of mistletoe extract (Iscador M). Induction of sarcoma and sarcoma-induced death were inhibited completely at a concentration of 1 mg Iscador/dose. The concentration needed for 50% inhibition was found to be 0.0166 mg Iscador/dose. Mistletoe extract was also found to inhibit lung metastasis induced by B16F10 melanoma cells in mice. Simultaneous administration of the Viscum album extract inhibited lung nodule formation by 92.0% and produced a 71.3% increase in life span.
Kuttan
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G
Amala Cancer Research Centre, Trissur, Kerala State, India.
Menon
L G
LG
Antony
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S
Kuttan
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R
D000818:Animals; D016588:Anticarcinogenic Agents / Q000627:therapeutic use*; D000972:Antineoplastic Agents, Phytogenic / Q000627:therapeutic use*; D005260:Female; D008175:Lung Neoplasms / Q000517:prevention & control / Q000556:secondary; D008545:Melanoma / Q000473:pathology / Q000517:prevention & control; D051379:Mice; D008810:Mice, Inbred C57BL; D014784:Mistletoe; D009362:Neoplasm Metastasis / Q000517:prevention & control*; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D010940:Plant Proteins; D010946:Plants, Medicinal; D012513:Sarcoma, Experimental / Q000188:drug therapy / Q000473:pathology
D016588:Anticarcinogenic Agents; D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts; D010940:Plant Proteins; C077177:viscum album peptide