title: Presence of multiple functional polyadenylation signals in the 3'-untranslated region of human corticotropin receptor cDNA.
abstract: We present 2.59 kb of the 3'-non-coding region of the ACTH receptor cDNA that contains seven potential polyadenylation signals. Among these signals, five are functional as detected by 3'-RACE and are consistent with the transcripts of 1.8, 3.4 and 4 kb visualized on Northern blots. We propose that the most likely molecular mechanism for the multiple ACTH-R mRNA transcripts is the alternative use of polyadenylation signals.
authors.affiliation: INSERM-INRA U 418, Hôpital Debrousse, Lyon, France. pdurand@univ-lyon1.fr
authors.forename: A
authors.initials: A
authors.lastname: Penhoat
authors.forename: D
authors.initials: D
authors.lastname: Naville
authors.forename: C
authors.initials: C
authors.lastname: Jaillard
authors.forename: P
authors.initials: P
authors.lastname: Durand
authors.forename: M
authors.initials: M
authors.lastname: Bégeot
mesh_terms: D001483:Base Sequence; D018076:DNA, Complementary / Q000235:genetics*; D005786:Gene Expression Regulation; D006801:Humans; D008969:Molecular Sequence Data; D011061:Poly A / Q000235:genetics; D012333:RNA, Messenger / Q000235:genetics; D018043:Receptors, Corticotropin / Q000235:genetics*
chemical_list: D018076:DNA, Complementary; D012333:RNA, Messenger; D018043:Receptors, Corticotropin; D011061:Poly A