Platelet [3H]imipramine and [3H]paroxetine binding in depressed patients.
[3H]Paroxetine and [3H]imipramine binding to blood platelet membranes was simultaneously measured in 63 control subjects and 18 patients with DSM-III-R criteria for major depression with melancholia. Both binding sites showed significantly different (p < 0.001) maximum binding (Bmax) and equilibrium dissociation constant (Kd) values. Age was not correlated with either [3H]imipramine Bmax or Kd values, but a negative correlation was found between [3H]paroxetine Bmax and age in healthy controls. Furthermore, depressed patients showed significantly lower [3H]imipramine Bmax values (p < 0.001) and higher Kd values (p < 0.001) in comparison to the control group. No differences were observed in [3H]paroxetine Bmax and Kd values between the two groups.
Rosel
P
P
Hormone Unit, Hospital Princeps d'Espanya, Barcelona, Spain.
Menchón
J M
JM
Vallejo
J
J
Arranz
B
B
Navarro
M A
MA
Lirón
F
F
Alvarez
P
P
D000328:Adult; D000367:Age Factors; D000368:Aged; D000928:Antidepressive Agents / Q000097:blood / Q000493:pharmacokinetics*; D001665:Binding Sites; D001792:Blood Platelets; D003866:Depressive Disorder / Q000523:psychology*; D005260:Female; D006801:Humans; D007099:Imipramine / Q000097:blood / Q000493:pharmacokinetics*; D008297:Male; D008875:Middle Aged; D017374:Paroxetine / Q000097:blood / Q000493:pharmacokinetics*
D000928:Antidepressive Agents; D017374:Paroxetine; D007099:Imipramine