[The effect of cholecystokinin octapeptide on ethanol-induced changes in motor activity and in dopamine metabolism in the nucleus accumbens of the rat brain].
The effect of intraventricular injection of cholecystokinin-octapeptide (CCK-8) in doses of 0.1875; 0.375; 0.75 and 1.5 micrograms/rat on the extracellular level of dopamine (DA) and its metabolites (DOPAC and HVA) after intraperitoneal injection of 1.5 g/kg ethanol was studied by microdialysis in n. accumbens of the brain of freely moving rats. CCK in a dose of 0.75 mg had no effect on the DA level, but significantly reduced the ethanol-induced increased DOPAC and HVA level. The effect of intraventricular injection of 0.75 microgram/rat CCK-8 on the motor activity of rats after intraperitoneal injection of ethanol (1.5 g/kg) was studied by the open field method. CCK-8 blocked the ethanol-induced inhibition of rat motor activity.
Medvedeva
O F
OF
Sudakova
S K
SK
Anokhina
I P
IP
Kianmaa
K
K
D000427:Alcohol Deterrents / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D002492:Central Nervous System Depressants / Q000494:pharmacology*; D004298:Dopamine / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D000431:Ethanol / Q000494:pharmacology*; D007276:Injections, Intraventricular / Q000379:methods; D008297:Male; D017551:Microdialysis / Q000379:methods; D009043:Motor Activity / Q000187:drug effects*; D009714:Nucleus Accumbens / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012844:Sincalide / Q000008:administration & dosage / Q000494:pharmacology*
D000427:Alcohol Deterrents; D002492:Central Nervous System Depressants; D000431:Ethanol; D012844:Sincalide; D004298:Dopamine