NK cells, macrophages, and humoral immune responses are dominant in primary nonfunction of islet grafts in the dog-to-rat xenotransplant model.
Deng
S
S
Department of Surgery, University of Pennsylvania Medical Center, Philadelphia 19104, USA.
Ketchum
R J
RJ
Kucher
T
T
Weber
M
M
Naji
A
A
Brayman
K L
KL
D000818:Animals; D000911:Antibodies, Monoclonal; D000917:Antibody Formation; D000961:Antilymphocyte Serum / Q000494:pharmacology; D001402:B-Lymphocytes / Q000276:immunology*; D001786:Blood Glucose / Q000378:metabolism; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000601:surgery*; D004285:Dogs; D005682:Gadolinium / Q000494:pharmacology; D006085:Graft Survival / Q000502:physiology; D006146:Guanidines / Q000494:pharmacology; D007166:Immunosuppressive Agents / Q000494:pharmacology; D007515:Islets of Langerhans / Q000276:immunology* / Q000473:pathology; D007694:Killer Cells, Natural / Q000276:immunology*; D008264:Macrophages / Q000276:immunology*; D051381:Rats; D011917:Rats, Inbred Lew; D011923:Rats, Nude; D014183:Transplantation, Heterologous / Q000276:immunology* / Q000473:pathology
D000911:Antibodies, Monoclonal; D000961:Antilymphocyte Serum; D001786:Blood Glucose; D006146:Guanidines; D007166:Immunosuppressive Agents; D005682:Gadolinium; C004479:pimagedine