title: Synthesis and biological properties of some 2H-1-benzopyrano[7,8-b][1,4]benzodioxin-2-ones.
abstract: The synthesis of 2H-benzopyrano[7,8-b][1,4]tetrahydrobenzodioxin-2-ones and 2H-benzopyrano [7,8-b][1,4]benzodioxin-2-ones is reported. This class of compounds, prepared with the aim of obtaining new monofunctional photosensitizing drug, appears to be ineffective upon UVA irradiation but shows a moderate but significant activity in the dark.
authors.affiliation: Centro di Studio sulla Chimica del Farmaco e dei Prodotti Biologicamente Attivi, CNR, Padova, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Rodighiero
authors.forename: A
authors.initials: A
authors.lastname: Chilin
authors.forename: A
authors.initials: A
authors.lastname: Guiotto
authors.forename: C
authors.initials: C
authors.lastname: Marzano
authors.forename: F
authors.initials: F
authors.lastname: Baccichetti
authors.forename: F
authors.initials: F
authors.lastname: Carlassare
authors.forename: F
authors.initials: F
authors.lastname: Bordin
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001578:Benzopyrans / Q000138:chemical synthesis* / Q000494:pharmacology; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy; D004273:DNA, Neoplasm / Q000096:biosynthesis; D004147:Dioxins / Q000138:chemical synthesis* / Q000494:pharmacology; D006367:HeLa Cells; D006801:Humans; D017319:Photosensitizing Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D013604:T-Phages / Q000187:drug effects; D014407:Tumor Cells, Cultured; D014466:Ultraviolet Rays
chemical_list: D000970:Antineoplastic Agents; D001578:Benzopyrans; D004273:DNA, Neoplasm; D004147:Dioxins; D017319:Photosensitizing Agents