[Clinical significance of detection and quantification of hepatitis C virus RNA in hemodialysis: proposal for a rational diagnostic strategy].
Viral infections due to hepatitis C virus in hemodialysis patients are frequent and have a potential risk of progression towards chronicity. Biochemical and viral markers of infection, are transaminases level, anti-HCV serology and the detection of HCV RNA, respectively. A rational strategy based on routine use of these three diagnostic tools is proposed in order to avoid unnecessary assays and to increase in the case of health cost control, the cost/efficacy ratio. The latter is set up, in the sero-negative hemodialysed, on the early detection of infection by the hepatitis C virus in order to consider of a therapeutic which is able to cure patients and to avoid the ineluctable passage towards chronicity; in hemodialysed with positive HCV serology, the detection of HCV RNA allows to establish the infectiosity status of these hemodialysis patients. It is therefore very important to evaluate prospectively this diagnosis approach in hemodialysis patients.
Halfon
P
P
Laboratoire Alphabio, Marseille.
Pol
S
S
Sayada
C
C
Izopet
J
J
Rostaing
L
L
Ouzan
D
D
D005838:Genotype; D016174:Hepacivirus / Q000235:genetics* / Q000276:immunology; D006526:Hepatitis C / Q000635:transmission / Q000821:virology*; D018937:Hepatitis C Antibodies / Q000032:analysis; D006801:Humans; D012367:RNA, Viral / Q000032:analysis*; D006435:Renal Dialysis
D018937:Hepatitis C Antibodies; D012367:RNA, Viral