Induction of tolerance and mossy fibre neuropeptide-Y expression in the contralateral hippocampus following a unilateral intrahippocampal kainic acid injection in the rat.
We have previously reported an ectopic expression of neuropeptide-Y (NPY) immunoreactivity in mossy fibres (MFs) in the contralateral hippocampus following a unilateral intrahippocampal (IH) injection of kainic acid (KA). In the present study we report that, in addition to MF NPY expression, unilateral IH KA injections also induce tolerance towards a subsequent intracerebroventricular (ICV) contralateral KA injection, resulting in a reduction in the number of overt seizures and degree of cell loss.
El Bahh
B
B
Laboratoire de Neurobiologie et Neuro-Imagerie Expérimentales, Université de Bordeaux II, France.
Lurton
D
D
Sundstrom
L E
LE
Rougier
A
A
D000818:Animals; D004361:Drug Tolerance; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism*; D007608:Kainic Acid / Q000494:pharmacology*; D008297:Male; D009412:Nerve Fibers / Q000378:metabolism*; D009478:Neuropeptide Y / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar
D009478:Neuropeptide Y; D007608:Kainic Acid