title: [Congenital toxoplasmosis with hydrocephalus diagnosed in utero: outcome of treatment].
abstract: BACKGROUND
  The neurological outcome for severe toxoplasmosis can be poor despite appropriate management.
  
  
  METHODS
  A maternal toxoplasma infection occurred at 16 weeks of amenorrhoea; prenatal diagnosis was attempted at 20 weeks, fetal infection was confirmed by mouse inoculation at the 30th week. Pyrimethamine plus sulfadiazine treatment was initiated. However, at 37 weeks of amenorrhoea, sonographic examination of the fetus detected hydrocephalus. Despite prompt ventriculo-peritoneal shunting after birth and medical treatment of toxoplasmosis, the neurological developmental outcome was complicated and prognosis is poor at 5 years of age.
  
  
  CONCLUSIONS
  This case shows that parents must be carefully warned about risks of a prenatal toxoplasmosis.
authors.affiliation: Service de parasitologie-mycologie, hôpital Bretonneau, Tours, France.
authors.forename: F
authors.initials: F
authors.lastname: Cotty
authors.forename: M A
authors.initials: MA
authors.lastname: Carpentier
authors.forename: P
authors.initials: P
authors.lastname: Descamps
authors.forename: F
authors.initials: F
authors.lastname: Perrotin
authors.forename: D
authors.initials: D
authors.lastname: Richard-Lenoble
mesh_terms: D000890:Anti-Infective Agents / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006849:Hydrocephalus / Q000150:complications* / Q000000981:diagnostic imaging / Q000601:surgery; D007231:Infant, Newborn; D011247:Pregnancy; D011739:Pyrimethamine / Q000627:therapeutic use; D013411:Sulfadiazine / Q000627:therapeutic use; D014125:Toxoplasmosis, Congenital / Q000150:complications* / Q000188:drug therapy; D016896:Treatment Outcome; D016216:Ultrasonography, Prenatal
chemical_list: D000890:Anti-Infective Agents; D013411:Sulfadiazine; D011739:Pyrimethamine