Eosinophil protein X concentration is dependent on eosinophil concentration.
The relationship between the eosinophil concentration and the serum eosinophil protein X concentration was investigated in 80 subjects. Higher eosinophil counts resulted in obviously increased serum eosinophil protein X concentrations. However, the amount of eosinophil protein X released per eosinophil granulocyte is significantly higher in subjects with lower eosinophil counts. Atopic subjects (N = 19) show a significantly higher eosinophil concentration (p = 0.002) and eosinophil protein X concentration (p = 0.004) and a significantly lower eosinophil protein X/eosinophil ratio (p = 0.02), compared with non-atopic subjects (N = 61). However, there appears to be no difference between the concentration of eosinophil protein X in atopic and non-atopic subjects if the eosinophil concentration is taken into account. When using eosinophil protein X as an indicator of eosinophil activation, for instance in asthmatic subjects, the eosinophil count should also be considered for correct clinical interpretation of results.
Pronk-Admiraal
C J
CJ
Department of Clinical Chemistry, Haematology and Immunology, Medical Centre Alkmaar, The Netherlands.
Bartels
P C
PC
D000293:Adolescent; D000328:Adult; D001798:Blood Proteins / Q000737:chemistry*; D047208:Eosinophil-Derived Neurotoxin; D004804:Eosinophils / Q000737:chemistry*; D005260:Female; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000097:blood; D007073:Immunoglobulin E / Q000097:blood; D007958:Leukocyte Count; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D012260:Ribonucleases
D001798:Blood Proteins; D007073:Immunoglobulin E; D047208:Eosinophil-Derived Neurotoxin; D012260:Ribonucleases