[An immunoenzyme test system for the identification of typical and atypical strains of the plague microbe].
The authors have developed the optimal variant of the enzyme immunoassay system that contains plague murine monoclonal and equine polyclonal immunoglobulins and identified all plague microbe strains at a high sensitivity (3.84 m.cl/ml). The cross reactivity of monoclonal antibodies with some pseudotuberculosis agent strains does not prevent from using the developed test system for laboratory diagnosis of plague, particularly while isolating atypical (capsule- or plasmid-free) variants of Y. pestis, taking into account parallel special diagnostic tests for pseudotuberculosis.
Devdariani
Z L
ZL
Fedorova
V A
VA
Solodovnikov
N S
NS
Plotnikov
O P
OP
Shul'gina
I V
IV
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D000918:Antibody Specificity; D003429:Cross Reactions; D006736:Horses; D006825:Hybridomas / Q000276:immunology; D007124:Immunoenzyme Techniques / Q000295:instrumentation*; D007136:Immunoglobulins / Q000276:immunology; D008070:Lipopolysaccharides / Q000276:immunology; D051379:Mice; D010957:Plasmids / Q000276:immunology; D012680:Sensitivity and Specificity; D015010:Yersinia pestis / Q000276:immunology*; D015011:Yersinia pseudotuberculosis / Q000276:immunology
D000911:Antibodies, Monoclonal; D007136:Immunoglobulins; D008070:Lipopolysaccharides