title: Plasma levels of cyclic GMP, immune parameters and depressive status during interferon therapy. A prospective study in Japan.
abstract: In this report, we investigated the relationship between depressive symptoms and plasma interferon (IFN)-alpha-like immunoreactivity, cyclic GMP (cGMP) and soluble interleukin-2 receptor (sIL-2R) levels during IFN therapy. An altered mood state was observed in 5 of 26 patients. IFN-alpha-like immunoreactivity in the depressed group tended to be elevated. cGMP levels of depressed patients were significantly greater than those of control subjects before and 6 weeks after IFN therapy. However, sIL-2R levels were not different between the two groups. These results suggest that a number of patients suffered from depression during IFN therapy and that patients had greater concentrations of cGMP levels.
authors.affiliation: Department of Psychiatry and Neurosciences, Hiroshima Univeristy School of Medicine, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Kagaya
authors.forename: Y
authors.initials: Y
authors.lastname: Uchitomi
authors.forename: E
authors.initials: E
authors.lastname: Takezaki
authors.forename: M
authors.initials: M
authors.lastname: Fukue
authors.forename: K
authors.initials: K
authors.lastname: Tsukano
authors.forename: A
authors.initials: A
authors.lastname: Kugaya
authors.forename: H
authors.initials: H
authors.lastname: Minagawa
authors.forename: M
authors.initials: M
authors.lastname: Takebayashi
authors.forename: H
authors.initials: H
authors.lastname: Zensho
authors.forename: T
authors.initials: T
authors.lastname: Oyamada
authors.forename: S
authors.initials: S
authors.lastname: Yamawaki
mesh_terms: D000368:Aged; D006152:Cyclic GMP / Q000097:blood*; D003866:Depressive Disorder / Q000139:chemically induced* / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D007372:Interferons / Q000009:adverse effects*; D007564:Japan; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies
chemical_list: D007372:Interferons; D006152:Cyclic GMP