title: Isolation and structure elucidation of ardisenone: a new, cytotoxic alkenylphenol from Ardisia iwahigensis.
abstract: A methanol extract of leaves and twigs from Ardisia iwahigensis demonstrated toxicity toward brine shrimp as well as LNCaP, ZR-75-1, and Lu1 human cancer cells in culture. A novel alkenylphenol, (Z)-1,16-bis(3-hydroxy-5-methoxyphenyl)-10-hexadecene-1,15-dione (ardisenone) (1), was isolated from the extract by bioassay-directed fractionation. This compound demonstrated moderate cytotoxicity against BC1, Lu1, Col2, KB, KB-V1, and LNCaP cell lines.
authors.affiliation: Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago 60612, USA.
authors.forename: F D
authors.initials: FD
authors.lastname: Horgen
authors.forename: H
authors.initials: H
authors.lastname: Guinaudeau
authors.forename: J M
authors.initials: JM
authors.lastname: Pezzuto
authors.forename: D D
authors.initials: DD
authors.lastname: Soejarto
authors.forename: N R
authors.initials: NR
authors.lastname: Farnsworth
authors.forename: F
authors.initials: F
authors.lastname: Agcaoili
authors.forename: G
authors.initials: G
authors.lastname: de los Reyes
authors.forename: R A
authors.initials: RA
authors.lastname: Edrada
mesh_terms: D000818:Animals; D000840:Anisoles / Q000302:isolation & purification* / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology; D001156:Artemia; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D013055:Spectrophotometry, Infrared; D014407:Tumor Cells, Cultured
chemical_list: D000840:Anisoles; D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts; C106399:ardisenone