[Posterior urethral valve: determining factors of long-term results].
Posterior urethral valves (PUV) is the most common congenital urine flow impairment in boys. Long-term prognosis involves: renal function impaired in 30 to 50% of PUV and leading to hyperdiuresis, low GFR and acidosis; bladder urodynamics impaired in 75% of PUV with abnormal urine storage, abnormal micturition and vesicoureteric reflux. Incontinence and recurrent urinary tract infections commonly reflect bladder and renal failures; abnormal bladder outlet leads to incontinence and abnormal ejaculation. The roles of antenatal treatments (vesico-amniotic shunts), neonatal treatments (resuscitation and endoscopic treatment of PUV) and long-term treatments (urinary diversions, bladder augmentation, alpha blockers, anticholinergic, dialysis and renal transplant) in the long-term outcomes of PUV are reviewed.
Mouriquand
P D
PD
Great Ormond Street Hospital for Sick Children, Institute of Child Health, University of London.
D002648:Child; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D011295:Prenatal Care; D011379:Prognosis; D051437:Renal Insufficiency / Q000209:etiology / Q000628:therapy; D014521:Urethra / Q000002:abnormalities*; D014522:Urethral Diseases / Q000209:etiology; D014524:Urethral Obstruction / Q000150:complications* / Q000601:surgery; D001745:Urinary Bladder Diseases / Q000209:etiology