title: Malaria in Mvumi, central Tanzania and the in vivo response of Plasmodium falciparum to chloroquine and sulphadoxine pyrimethamine.
abstract: A study on the prevalence of malaria and the response of Plasmodium falciparum to chloroquine and sulphadoxine-pyrimethamine was conducted in Mvumi area of central Tanzania. Splenomegaly was observed at a rate of 62% and 36% in children and adults respectively. Crude malaria parasite rate was 55.4% in children and 32% in adults. Plasmodium falciparum accounted for the highest proportion (62.7%) of the malaria parasites in the area. This malaria parasite was sensitive to standard dosage of either chloroquine or sulphadoxine-pyrimethamine. Sulphadoxine-pyrimethamine cleared the parasites to undetectable levels by day seven of administration whereas chloroquine cleared parasitaemia in 91% of the subjects by the seventh day. Despite the virtual absence of adult Anopheles mosquitoes during the study period, a larval survey indicated that breeding of Anopheles gambiae s.l. was taking place in nearby irrigation streams. Culex quinquefasciatus was the dominant man-biting mosquito in the area.
authors.affiliation: National Institute for Medical Research, Muheza, Tanzania.
authors.forename: J V
authors.initials: JV
authors.lastname: Wakibara
authors.forename: L E
authors.initials: LE
authors.lastname: Mboera
authors.forename: B T
authors.initials: BT
authors.lastname: Ndawi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D000852:Anopheles; D000962:Antimalarials; D002648:Child; D002738:Chloroquine; D003430:Cross-Sectional Studies; D003465:Culex; D004338:Drug Combinations; D004351:Drug Resistance; D006801:Humans; D007303:Insect Vectors; D016778:Malaria, Falciparum / Q000188:drug therapy* / Q000453:epidemiology*; D008875:Middle Aged; D015995:Prevalence; D011739:Pyrimethamine / Q000737:chemistry*; D013413:Sulfadoxine / Q000737:chemistry*; D013636:Tanzania / Q000453:epidemiology
chemical_list: D000962:Antimalarials; D004338:Drug Combinations; C001205:fanasil, pyrimethamine drug combination; D013413:Sulfadoxine; D002738:Chloroquine; D011739:Pyrimethamine