title: Synthesis and evaluation of new Reissert analogs as HIV-1 RT inhibitors. 2. Benzo[f]quinoline and pyridine derivatives.
abstract: The synthesis and preliminary evaluation of new benzo[f]quinoline and pyridine derivatives, obtained by application of the Reissert method and its modifications, as HIV-1 RT inhibitors and anti-infectives are presented. The most active products against HIV-1 RT wild type are the ethyl 2-cyano-1,2-dihydrobenzo[f]quinoline-1-carboxylate 2b, propyl 2-cyano-1,2-dihydrobenzo[f]quinoline-1-carboxylate 2c, and 2-cyano-1-(2'-furoyl)-1,2-dihydrobenzo[f]quinoline 2n, which maintain their activity against the mutant type P236L, resulting inactive against the Y181C type. Using the data previously obtained by our research team for analogous series derived from quinoline as reference, the compounds which have now been obtained present an increase in the cytotoxic character attributable to the introduction of a benzene ring fused with the quinoline base nucleus, as well as a decrease of the activity as HIV-1 RT inhibitors when the quinoline benzenic ring is eliminated.
authors.affiliation: Medicinal Chemistry, Universidad de Navarra, Pamplona, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Monge
authors.forename: E
authors.initials: E
authors.lastname: Alvarez
authors.forename: C
authors.initials: C
authors.lastname: San Martín
authors.forename: E
authors.initials: E
authors.lastname: Nadal
authors.forename: I
authors.initials: I
authors.lastname: Ruiz
authors.forename: M
authors.initials: M
authors.lastname: Font
authors.forename: J J
authors.initials: JJ
authors.lastname: Martínez-Irujo
authors.forename: E
authors.initials: E
authors.lastname: Santiago
authors.forename: I
authors.initials: I
authors.lastname: Prieto
authors.forename: J J
authors.initials: JJ
authors.lastname: Lasarte
authors.forename: P
authors.initials: P
authors.lastname: Sarobe
authors.forename: F
authors.initials: F
authors.lastname: Borrás
mesh_terms: D019380:Anti-HIV Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002460:Cell Line; D054303:HIV Reverse Transcriptase / Q000037:antagonists & inhibitors*; D006801:Humans; D011725:Pyridines / Q000138:chemical synthesis* / Q000494:pharmacology; D011804:Quinolines / Q000138:chemical synthesis* / Q000494:pharmacology; D018894:Reverse Transcriptase Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D019380:Anti-HIV Agents; D011725:Pyridines; D011804:Quinolines; D018894:Reverse Transcriptase Inhibitors; C039108:benzo(f)quinoline; D054303:HIV Reverse Transcriptase