title: Thyroid volume and function after 131I treatment of diffuse non-toxic goitre.
abstract: OBJECTIVE
  Traditional treatment of diffuse non-toxic goitre are thyroid hormone suppression or surgery. When treating nodular non-toxic goitre with 131I treatment a reduction in thyroid volume to about 50% has been observed. In the present study we evaluated the effect of 131I treatment of diffuse non-toxic goitre.
  
  
  METHODS
  Retrospective study of patients treated for a diffuse non-toxic goitre and followed by evaluation of thyroid volume measured by ultrasound.
  
  
  METHODS
  Ten selected patients from our out-patient clinic with diffuse non-toxic goitre.
  
  
  METHODS
  Thyroid volume was measured by ultrasound and thyroid function by serum values of T4, T3, T3 uptake ratio, TSH, TSH receptor antibodies and thyroid peroxidase antibodies (anti-TPO). Measurements were performed before and 1, 3, 6 and 12 months (and 18 months (n = 7), thyroid volume measured in six patients)) after 131I treatment.
  
  
  RESULTS
  Thyroid volume declined in all patients from median 41 (range 27-160) ml to 20 (range 9-108) ml over 1 year, a reduction of 47%. One patient developed transient and one persistent hypothyroidism in the follow-up period. Both had elevated anti-TPO levels before treatment (331 and 9185 U/ml) and demonstrated titre increases of 2.5 and 30 times after 3 and 6 months, respectively. Pretreatment values were reached after 1 year. The other eight patients had normal anti-TPO levels and free T4 and T3 indices did not change during follow-up, whereas serum TSH levels demonstrated upward trends within the normal range (P < 0.05). TSH receptor antibodies were normal and remained so in all patients.
  
  
  CONCLUSIONS
  131I treatment of diffuse non-toxic goitre reduces thyroid volume by approximately 50% within 12-18 months. Hypothyroidism, during a limited follow-up period, developed only in patients with positive anti-TPO levels before treatment.
authors.affiliation: Department of Endocrinology F, Herlev University Hospital, Denmark.
authors.forename: B
authors.initials: B
authors.lastname: Nygaard
authors.forename: J
authors.initials: J
authors.lastname: Farber
authors.forename: A
authors.initials: A
authors.lastname: Veje
authors.forename: J E
authors.initials: JE
authors.lastname: Hansen
mesh_terms: D000328:Adult; D001323:Autoantibodies / Q000097:blood; D005260:Female; D005500:Follow-Up Studies; D006042:Goiter / Q000473:pathology / Q000503:physiopathology / Q000532:radiotherapy*; D006801:Humans; D007453:Iodide Peroxidase / Q000276:immunology; D007457:Iodine Radioisotopes / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D011989:Receptors, Thyrotropin / Q000276:immunology; D012189:Retrospective Studies; D013961:Thyroid Gland / Q000473:pathology* / Q000503:physiopathology; D013963:Thyroid Hormones / Q000097:blood
chemical_list: D001323:Autoantibodies; D007457:Iodine Radioisotopes; D011989:Receptors, Thyrotropin; D013963:Thyroid Hormones; D007453:Iodide Peroxidase