Pharmacodynamic effects of amoxicillin versus cefotaxime against penicillin-susceptible and penicillin-resistant pneumococcal strains: a phase I study.
Serum bactericidal activity against a penicillin-susceptible strain and a penicillin-resistant strain of Streptococcus pneumoniae (amoxicillin and cefotaxime MICs, 0.001 and 1 microg/ml, respectively, and MBCs, 0.01 and 2 microg/ml, respectively) was measured in 12 healthy volunteers who each received an oral 875-mg dose of amoxicillin and an intramuscular 1-g dose of cefotaxime in a crossover fashion. The areas under the bactericidal activity-time curves for the two strains were found to be similar for both antibiotics despite the significantly higher (P < 0.002) AUC/MIC and peak level/MIC values for cefotaxime.
Aguilar
L
L
Medical Department, SmithKline Beecham Pharmaceuticals, Madrid, Spain.
Rosendo
J
J
Balcabao
I P
IP
Martín
M
M
Giménez
M J
MJ
Frías
J
J
Prieto
J
J
D000328:Adult; D000658:Amoxicillin / Q000097:blood / Q000493:pharmacokinetics / Q000494:pharmacology*; D002439:Cefotaxime / Q000097:blood / Q000493:pharmacokinetics / Q000494:pharmacology*; D002511:Cephalosporins / Q000097:blood / Q000493:pharmacokinetics / Q000494:pharmacology*; D018592:Cross-Over Studies; D006801:Humans; D008297:Male; D010403:Penicillin Resistance; D010406:Penicillins / Q000097:blood / Q000493:pharmacokinetics / Q000494:pharmacology*; D015610:Serum Bactericidal Test; D013296:Streptococcus pneumoniae / Q000187:drug effects*
D002511:Cephalosporins; D010406:Penicillins; D000658:Amoxicillin; D002439:Cefotaxime