Peptides in membranes: tipping the balance of membrane stability.
This review describes a class of peptides that associate with lipids in membranes and are commonly known as 'oblique-orientated peptides'. Owing to an asymmetric distribution of hydrophobic residues along the axis of the alpha-helix, such peptides can destabilize membranes or lipid cores, thereby facilitating such cellular processes as vesicular fusion or protein transport across subcellular compartments, as well as remodelling of lipid cores.
Brasseur
R
R
Centre Biophysique Moleculaire Numerique, Fac. Agronomiques, Gembloux, Belgium.
Pillot
T
T
Lins
L
L
Vandekerckhove
J
J
Rosseneu
M
M
D000544:Alzheimer Disease / Q000209:etiology; D001692:Biological Transport; D002462:Cell Membrane / Q000502:physiology*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D050356:Lipid Metabolism; D008561:Membrane Fusion; D008563:Membrane Lipids / Q000378:metabolism; D008565:Membrane Proteins / Q000737:chemistry* / Q000502:physiology; D021382:Protein Sorting Signals / Q000737:chemistry; D014764:Viral Proteins / Q000737:chemistry
D008563:Membrane Lipids; D008565:Membrane Proteins; D021382:Protein Sorting Signals; D014764:Viral Proteins