title: [The participation of the central and peripheral kappa-opiate receptors in the mechanism of the anti-arrhythmia action of benzeneacetamide derivatives].
abstract: When injected intraperitoneally in a dose of 8 mg/kg, U-62066, the selective agonist of kappa-opioid receptors, exhibits antiarrhythmic properties in epinephrine-induced arrhythmias in rats. In cerebroventricular injection, the kappa-agonists U-50,488 and [D-ala2]-dynorphin A(1-13) manifest proarrhythmic properties. Preliminary administration of the kappa-antagonist nor-binaltorphimine completely removes the proarrhythmic and antiarrhythmic effect of kappa-agonists. The antiarrhythmic effect of U-62006 is believed to be associated with activation of peripheral kappa-receptors.
authors.forename: L N
authors.initials: LN
authors.lastname: Maslov
authors.forename: Iu B
authors.initials: IuB
authors.lastname: Lishmanov
authors.forename: A V
authors.initials: AV
authors.lastname: Krylatov
authors.forename: D S
authors.initials: DS
authors.lastname: Ugdyzhekova
mesh_terms: D000081:Acetamides / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000188:drug therapy; D004353:Drug Evaluation, Preclinical; D004837:Epinephrine; D008024:Ligands; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D017473:Receptors, Opioid, kappa / Q000819:agonists / Q000037:antagonists & inhibitors / Q000187:drug effects*
chemical_list: D000081:Acetamides; D000889:Anti-Arrhythmia Agents; D008024:Ligands; D017473:Receptors, Opioid, kappa; D004837:Epinephrine