[The concentration of Tamsulosin hydrochloride in the blood and prostatic tissue of the patients in benign prostatic hyperplasia].
BACKGROUND
The penetration of Tamsulosin hydrochloride into the blood and the prostatic tissue was examined.


METHODS
Fifty-two patients with benign prostatic hyperplasia treated with transurethral resection of the prostate were entered in this study. This drug was administered orally in a dose of 2.0 mg once a day for 7 to 179 days preoperatively. The blood samples were taken simultaneously at the time of the prostatic tissue sampling.


RESULTS
1. The correlation coefficient was hardly significant between aging and concentration of the drug in the blood or in the prostatic tissue. 2. The correlation coefficient was hardly significant between the duration of the drug administration and concentration of the drug in the blood or the prostatic tissue. 3. The correlation coefficient was significant between the concentration of the drug in the blood and the prostatic tissue. 4. The fifty-two patients showed no significant adverse reactions during administration of the drug.


CONCLUSIONS
These results suggest that the drug can be administered safely to the aged even in a long-term and can be penetrated into the blood and the prostatic tissue with a positive correlation.
Morita
M
M
Department of Urology, TUR Section, Sendai Shakaihoken Hospital Sendai, Japan.
Numahata
K
K
Ogata
Y
Y
Suzuki
K
K
D000317:Adrenergic alpha-Antagonists / Q000097:blood / Q000493:pharmacokinetics*; D000368:Aged; D000369:Aged, 80 and over; D001692:Biological Transport; D006801:Humans; D008297:Male; D008875:Middle Aged; D011467:Prostate / Q000378:metabolism*; D011470:Prostatic Hyperplasia / Q000378:metabolism*; D013449:Sulfonamides / Q000097:blood / Q000493:pharmacokinetics*; D000077409:Tamsulosin
D000317:Adrenergic alpha-Antagonists; D013449:Sulfonamides; D000077409:Tamsulosin