How do DNA repair proteins locate damaged bases in the genome?
The genome is susceptible to the attack of reactive species that chemically modify the bases of DNA. If genetic information is to be transmitted faithfully to successive generations, it is essential that the genome be repaired. All organisms express proteins specifically dedicated to this task. But how do these proteins find the aberrant bases amongst the enormous number of normal ones?
Verdine
G L
GL
Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.
Bruner
S D
SD
D000818:Animals; D045647:DNA Glycosylases; D004260:DNA Repair; D006801:Humans; D009699:N-Glycosyl Hydrolases / Q000378:metabolism*; D011506:Proteins / Q000378:metabolism; D013379:Substrate Specificity
D011506:Proteins; D045647:DNA Glycosylases; D009699:N-Glycosyl Hydrolases