Behavioral methods and organic solvents: questions and consequences.
This paper reviews some illustrative examples of studies of human neurobehavioral effects from experimental as well as long-term occupational organic-solvent exposure. My objective is to present a selection of neurobehavioral solvent studies with the educational aim that we may hopefully learn from the early experiences of others. Some of the methodological problems encountered in these studies are discussed, as well as some reasons for the relative success of the work performed by certain Scandinavian research teams.
Iregren
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National Institute of Occupational Health, Solna, Sweden. airegren@nioh.se
D000818:Animals; D001519:Behavior / Q000187:drug effects*; D001522:Behavior, Animal / Q000187:drug effects*; D003430:Cross-Sectional Studies; D004353:Drug Evaluation, Preclinical; D006801:Humans; D009498:Neurotoxins / Q000009:adverse effects* / Q000633:toxicity; D016273:Occupational Exposure; D012997:Solvents / Q000009:adverse effects* / Q000633:toxicity; D018675:Toxicity Tests / Q000379:methods
D009498:Neurotoxins; D012997:Solvents