The complement system in chronic lymphocytic leukemia: a possible role in autoimmune manifestations.
We describe the complement system of three CLL patients who developed autoimmune complications in the course of their disease. The complement profile was pathological in both CLL patients with active autoimmune diseases, while it showed no deficiency in the patient with quiescent autoimmunity. The complement profile could be an early marker for development of autoimmunity in CLL patients
Lugassy
G
G
Institute of Hematology, Barzilai Medical Center, Ashkelon, Israel.
Schlesinger
M
M
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001172:Arthritis, Rheumatoid / Q000150:complications; D001327:Autoimmune Diseases / Q000209:etiology*; D003175:Complement C2 / Q000172:deficiency; D011415:Complement Factor B / Q000172:deficiency; D003165:Complement System Proteins / Q000032:analysis / Q000276:immunology*; D005260:Female; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000097:blood / Q000150:complications / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009404:Nephrotic Syndrome / Q000209:etiology*; D012010:Red-Cell Aplasia, Pure / Q000209:etiology*
D003175:Complement C2; D003165:Complement System Proteins; D011415:Complement Factor B