title: [Cream PUVA photochemotherapy].
abstract: Bath-PUVA-photochemotherapy lacks systemic side effects and requires low cumulative UVA doses, but a major disadvantage is the logistical requirement for bath tubs in a practice. We have developed an alternative form of topical PUVA therapy using a lipophilic emulsion vehicle for the photosensitizer 8-MOP (cream-PUVA-photochemo-therapy). A 0.0006% 8-MOP containing water-in-oil emulsion (30% H2O) was optimal for inducing photosensitivity in treated skin areas without increasing 8-MOP plasma levels. Increased skin photosensitivity was maximal 1 hour after cream application and persisted for 3 hours. We next assessed the effectiveness of cream-PUVA-photochemotherapy in the treatment of patients with chronic recalcitrant palmoplantar eczema (n = 10). In seven patients complete, and in two patients partial, remissions were observed after 40 treatments. Thus, cream-PUVA-photochemotherapy, which is easier to perform than bath-PUVA-photochemotherapy, is an effective, safe and low-cost modality, which may prove to become the topical PUVA therapy of choice for dermatological practitioners.
authors.affiliation: Universitäts-Hautklinik, Heinrich-Heine-Universität, Düsseldorf.
authors.forename: H
authors.initials: H
authors.lastname: Stege
authors.forename: M
authors.initials: M
authors.lastname: Berneburg
authors.forename: T
authors.initials: T
authors.lastname: Ruzicka
authors.forename: J
authors.initials: J
authors.lastname: Krutmann
mesh_terms: D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D006801:Humans; D008730:Methoxsalen / Q000008:administration & dosage* / Q000009:adverse effects; D009824:Ointments; D011701:PUVA Therapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000008:administration & dosage* / Q000009:adverse effects; D011565:Psoriasis / Q000175:diagnosis / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D009824:Ointments; D017319:Photosensitizing Agents; D008730:Methoxsalen