Therapeutic and imaging capacity of tumor-localizing radiosensitive Mn-porphyrin on SCCVII tumor-bearing C3H/He mice.
We synthesized a radiosensitizer KADTF, consisting of a hypoxic radiosensitizer, KU2280, bound to the side chain group of Mn-metalloporphyrin, which accumulates in tumor tissue. In the in vitro colony-forming activity test using HeLa cells, KADTF enhanced the effect of radiation under hypoxic conditions. Radiation therapy at 20 Gy, 1.5 h after infusion of KADTF (0.15 mM/kg), inhibited tumor growth more markedly than did a single radiation treatment. A clear tumor MR images of the SCCVII tumor was obtained at 1.5 h after administration of KADTF (0.1 mM/kg).
Nakajima
S
S
Division of Surgical Operation, Asahikawa Medical College, Japan.
Shigemi
N
N
Murakami
N
N
Aburano
T
T
Sakata
I
I
Maruyama
I
I
Inoue
M
M
Takemura
T
T
D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis* / Q000378:metabolism / Q000532:radiotherapy*; D002455:Cell Division / Q000528:radiation effects; D015687:Cell Hypoxia / Q000528:radiation effects; D006367:HeLa Cells / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008665:Metalloporphyrins / Q000138:chemical synthesis / Q000494:pharmacology*; D051379:Mice; D008809:Mice, Inbred C3H; D011838:Radiation-Sensitizing Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D014018:Tissue Distribution
C107480:KADTF radiosensitizer; D008665:Metalloporphyrins; D011838:Radiation-Sensitizing Agents