title: Multilocular thymic cysts associated with thymoma. A case report.
abstract: The association of multilocular thymic cysts (MTC) with thymoma is exceedingly rare, and the pathogenesis of this combination is controversial. We describe the case of a 42-year-old man with an anterior mediastinal mass found to contain MTC and thymoma. A multilocular cystic mass, measuring 13 x 6.5 x 2 cm, was found in the right lobe of the thymus, and contained a 4.7 x 2 cm thymoma in its center. Microscopic thymomas, lipomatously involuted remaining thymic tissue, and lymphoid follicles with germinal centers were found in the walls of MTC as well as in the left thymic lobe. Non-specific chronic inflammation was also present in the walls. In addition, microcysts, which were only found at the periphery of the thymoma and covered with epithelium, might have been formed secondarily by dilatation of the perivascular spaces and of Hassall's corpuscles. These findings suggest that a chronic inflammatory process was responsible for the early formation and enlargement of this patient's MTC, and that while the cavities of the MTC expanded to various degrees, the thymoma, which originated from one of the microscopic thymomas in the walls of MTC, increased in size, and grew to involve the remaining thymic tissue.
authors.affiliation: Department of Pathology, Kochi Medical School, Japan.
authors.forename: S B
authors.initials: SB
authors.lastname: Liang
authors.forename: Y
authors.initials: Y
authors.lastname: Ohtsuki
authors.forename: H
authors.initials: H
authors.lastname: Sonobe
authors.forename: J
authors.initials: J
authors.lastname: Iwata
authors.forename: M
authors.initials: M
authors.lastname: Furihata
authors.forename: E
authors.initials: E
authors.lastname: Ido
authors.forename: R
authors.initials: R
authors.lastname: Watanabe
authors.forename: K
authors.initials: K
authors.lastname: Ohmori
authors.forename: S
authors.initials: S
authors.lastname: Ohtsuka
mesh_terms: D000328:Adult; D015703:Antigens, CD / Q000378:metabolism; D015214:Antigens, Differentiation, Myelomonocytic / Q000378:metabolism; D018985:Epitopes, B-Lymphocyte / Q000378:metabolism; D006680:HLA Antigens / Q000378:metabolism; D006801:Humans; D007633:Keratins / Q000378:metabolism; D008297:Male; D008476:Mediastinal Cyst / Q000378:metabolism / Q000473:pathology*; D009418:S100 Proteins / Q000378:metabolism; D013945:Thymoma / Q000378:metabolism / Q000473:pathology*; D000097382:CD68 Molecule
chemical_list: D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D018985:Epitopes, B-Lymphocyte; D006680:HLA Antigens; D007633:Keratins; D009418:S100 Proteins; C067980:CD68 antigen, human; D000097382:CD68 Molecule