title: Current etiopathogenetic views in vulvar cancer.
abstract: We considered 59 patients, from 19 to 79 years, treated for vulvar neoplastic pathology (32 of 59 had multiple squamous neoplasias of the anogenital region). It appeared that vulvar cancer is a disease of aged women and in particular between sixty and seventy years, while it isn't common under the age of thirty years. It is a hormone-independent pathology. 85% of vulvar malignant tumors is constituted by squamous cell carcinomas. The principal risk factors are: 1) chronic vulvitis (in particular Lichen sclerosus); 2) leucoplachia, 3) immunosuppression, 4) coitus in a young woman with different partners, multiple abortions, 5) HPV infection (mostly HPV type 6 and 16), 6) other genital carcinomas, 7) capacity to activate or not protoncogenes and to produce interferon, 8) tobacco smoking, 9) VIN.
authors.affiliation: Department of Obstetrics and Gynecology, Second University of Naples, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Zarcone
authors.forename: G
authors.initials: G
authors.lastname: Mainini
authors.forename: E
authors.initials: E
authors.lastname: Carfora
authors.forename: A
authors.initials: A
authors.lastname: Cardone
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008875:Middle Aged; D027383:Papillomaviridae / Q000302:isolation & purification; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects; D014846:Vulvar Neoplasms / Q000209:etiology* / Q000473:pathology / Q000601:surgery