Number of correlates of membrane metabolism and long-term potentiation in rat brain slices.
Long-term potentiation was elicited in living slices of rat olfactory cortex by stimulation of the lateral olfactory tract. A group of interdependent parameters of membrane metabolism was studied, i.e., the kinetics of 45Ca metabolism, lipid peroxidation, and antioxidant defense; cytochemical measurements were made of Na+, K(+)-ATPase activity in neurons and glial cells; the functional (GTPase) activity of G-proteins was also studied. All parameters were compared with the bioelectrical activity of slices at three time points after tetanization, i.e., 3-5, 15, and 30 min. In most cases, regular phasic changes in metabolic parameters occurred, and their functional significance is discussed.
Emel'yanov
N A
NA
Laboratory of Functional Neurochemistry, I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg.
Glushchenko
T S
TS
Izvarina
N L
NL
Malikov
U M
UM
Nilova
N S
NS
Sokolova
N E
NE
Tokarev
A V
AV
D000109:Acetylcholine / Q000378:metabolism; D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D001921:Brain / Q000201:enzymology; D001923:Brain Chemistry / Q000502:physiology*; D002118:Calcium / Q000378:metabolism; D004558:Electric Stimulation; D020558:GTP Phosphohydrolases / Q000378:metabolism; D066298:In Vitro Techniques; D007700:Kinetics; D015227:Lipid Peroxidation / Q000502:physiology; D017774:Long-Term Potentiation / Q000502:physiology*; D008566:Membranes / Q000378:metabolism; D009457:Neuroglia / Q000378:metabolism; D009474:Neurons / Q000378:metabolism; D051381:Rats
D000975:Antioxidants; D020558:GTP Phosphohydrolases; D000109:Acetylcholine; D002118:Calcium