title: A family of mammalian Fringe genes implicated in boundary determination and the Notch pathway.
abstract: The formation of boundaries between groups of cells is a universal feature of metazoan development. Drosophila fringe modulates the activation of the Notch signal transduction pathway at the dorsal-ventral boundary of the wing imaginal disc. Three mammalian fringe-related family members have been cloned and characterized: Manic, Radical and Lunatic Fringe. Expression studies in mouse embryos support a conserved role for mammalian Fringe family members in participation in the Notch signaling pathway leading to boundary determination during segmentation. In mammalian cells, Drosophila fringe and the mouse Fringe proteins are subject to posttranslational regulation at the levels of differential secretion and proteolytic processing. When misexpressed in the developing Drosophila wing imaginal disc the mouse Fringe genes exhibit conserved and differential effects on boundary determination.
authors.affiliation: Department of Molecular Biology, Princeton University, New Jersey 08544, USA.
authors.forename: S H
authors.initials: SH
authors.lastname: Johnston
authors.forename: C
authors.initials: C
authors.lastname: Rauskolb
authors.forename: R
authors.initials: R
authors.lastname: Wilson
authors.forename: B
authors.initials: B
authors.lastname: Prabhakaran
authors.forename: K D
authors.initials: KD
authors.lastname: Irvine
authors.forename: T F
authors.initials: TF
authors.lastname: Vogt
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D019521:Body Patterning / Q000235:genetics*; D004330:Drosophila; D029721:Drosophila Proteins; D018507:Gene Expression Regulation, Developmental; D005964:Glucosyltransferases; D016695:Glycosyltransferases; D006602:Hexosyltransferases; D006801:Humans; D019476:Insect Proteins / Q000235:genetics*; D036341:Intercellular Signaling Peptides and Proteins; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins / Q000235:genetics*; D051379:Mice; D008969:Molecular Sequence Data; D005810:Multigene Family; D017351:N-Acetylglucosaminyltransferases; D009420:Nervous System / Q000737:chemistry / Q000196:embryology; D011499:Protein Processing, Post-Translational; D011506:Proteins / Q000235:genetics* / Q000378:metabolism; D012333:RNA, Messenger / Q000032:analysis; D051880:Receptors, Notch; D011993:Recombinant Fusion Proteins; D016415:Sequence Alignment; D015398:Signal Transduction / Q000235:genetics*; D019170:Somites; D014921:Wings, Animal / Q000254:growth & development
chemical_list: D029721:Drosophila Proteins; D019476:Insect Proteins; D036341:Intercellular Signaling Peptides and Proteins; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins; C497759:N protein, Drosophila; D011506:Proteins; D012333:RNA, Messenger; D051880:Receptors, Notch; D011993:Recombinant Fusion Proteins; D016695:Glycosyltransferases; D005964:Glucosyltransferases; D006602:Hexosyltransferases; C498393:LFNG protein, human; C498392:Lfng protein, mouse; C486343:Mfng protein, mouse; D017351:N-Acetylglucosaminyltransferases; C491317:Rfng protein, mouse; C106516:MFNG protein, human; C491318:RFNG protein, human; C090576:fng protein, Drosophila