title: [A comparative study of the taste sensitivity to phenylthiocarbamide in rats differing by the threshold of nervous system excitability].
abstract: Taste sensitivity to a bitter substance, phenylthiocarbamide (PTC) was studied in rat strains selected for the threshold of excitability of the nervous system. In the period of 17 days the drinking behaviour of the rats was estimated after giving them a series of PTC solutions with increasing concentrations and water as a control. The interstrain differences were found in the mean level of this index and its dynamics during the experimental period. Rats of the strain with high excitability showed the rhythmical changes of taste sensitivity to PTC related to the phases of moon rhythm. The obtained evidence points to relation between the sign under study and individual characteristics of the nervous system, namely, its excitability, and suggests the differences in activity of the second messenger system (Ca++, c-AMP and others) in the studied rat strains.
authors.forename: M B
authors.initials: MB
authors.lastname: Pavlova
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D004327:Drinking Behavior / Q000187:drug effects / Q000502:physiology; D008297:Male; D016081:Moon; D009424:Nervous System Physiological Phenomena; D010507:Periodicity; D010670:Phenylthiourea / Q000008:administration & dosage*; D051381:Rats; D011919:Rats, Inbred Strains; D012996:Solutions; D013652:Taste Threshold / Q000187:drug effects* / Q000502:physiology; D013997:Time Factors
chemical_list: D012996:Solutions; D010670:Phenylthiourea