Testing a genetic equilibrium across strata.
A score statistic for testing the Hardy-Weinberg law for data sampled from several populations with different allele frequencies is derived assuming a common coefficient of disequilibrium (odds ratio-type) across strata. The assumption can be examined by a chi-square goodness-of-fit test. It is unlikely such a model would be rejected in typical studies involving human populations. Under this model, a Wald-type test has substantially less power than the score test. An approximate formula for the sample size required for a specific power of the stratified score test for detecting departure from equilibrium is given.
Nam
J M
JM
Biostatistics Branch, National Cancer Institute, Rockville, Maryland 20892, USA.
D016009:Chi-Square Distribution; D005828:Genetics, Population; D006801:Humans; D008957:Models, Genetic; D009010:Monte Carlo Method; D010641:Phenotype