title: A psychophysiological study of the development of delirium in coronary care units.
abstract: This is a longitudinal investigation of the psychophysiological mechanism for the development of delirium in coronary care units (CCUs). Ten patients satisfying DSM-III-R diagnostic criteria for delirium (group D) and 10 controls (group C) were drawn from patients admitted to CCU. Electroencephalogram (EEG) and eye movement recordings were observed over the days that patients were admitted to CCU and on a control day of admission and compared for each group and between each day. In the D group, slowing of background EEG activity, particularly on day 2, and many R (rapid) group eye movements and RS type (rapid superimposed on slow) eye movements, particularly on day 3, were observed. That is, from days 2 to 3, EEG findings showed an improvement in consciousness, and eye movement recordings manifested signs of anxiety and tension. These psychophysiological findings can be used to explain the transition from prodromal delirium to obvious delirium, and are supported by clinical features.
authors.affiliation: Department of Neuropsychiatry, Tokyo Medical and Dental University School of Medicine, Japan.
authors.forename: E
authors.initials: E
authors.lastname: Matsushima
authors.forename: K
authors.initials: K
authors.lastname: Nakajima
authors.forename: H
authors.initials: H
authors.lastname: Moriya
authors.forename: M
authors.initials: M
authors.lastname: Matsuura
authors.forename: T
authors.initials: T
authors.lastname: Motomiya
authors.forename: T
authors.initials: T
authors.lastname: Kojima
mesh_terms: D014151:Anti-Anxiety Agents / Q000627:therapeutic use; D014150:Antipsychotic Agents / Q000627:therapeutic use; D003325:Coronary Care Units; D003327:Coronary Disease / Q000503:physiopathology* / Q000523:psychology*; D003693:Delirium / Q000188:drug therapy / Q000503:physiopathology* / Q000523:psychology*; D003975:Diazepam / Q000627:therapeutic use; D004569:Electroencephalography; D005133:Eye Movements; D005260:Female; D006220:Haloperidol / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales
chemical_list: D014151:Anti-Anxiety Agents; D014150:Antipsychotic Agents; D006220:Haloperidol; D003975:Diazepam