Wound healing activity of Leucas lavandulaefolia Rees.
Leucas lavandulaefolia Rees (Labiatae), commonly known as Halkusha, is a well-known plant in Indian traditional medicine. On the basis of its traditional use and literature references, this plant was selected for evaluation of its wound healing potential. A methanol extract of L. lavandulaefolia was examined for its wound healing activity both in the form of an ointment as well as an injection in two types of wound model in rats: (i) the excision wound model and (ii) the incision wound model. Both the injection and the ointment of the methanol extract of the plant material produced a significant response in both of the wound types tested. The results were also comparable to those of a standard drug, nitrofurazone, in terms of wound contracting ability, wound closure time, tensile strength and regeneration of tissues at the wound site.
Saha
K
K
Department of Pharmaceutical Technology, Faculty of Engineering and Technology, Jadavpur University, Calcutta, India.
Mukherjee
P K
PK
Das
J
J
Pal
M
M
Saha
B P
BP
D000818:Animals; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage / Q000494:pharmacology; D007194:India; D007274:Injections, Intraperitoneal; D008519:Medicine, Traditional; D000432:Methanol / Q000737:chemistry; D009583:Nitrofurazone / Q000008:administration & dosage / Q000494:pharmacology; D009824:Ointments; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D012015:Reference Standards; D013718:Tensile Strength; D014945:Wound Healing / Q000187:drug effects*
D000891:Anti-Infective Agents, Local; D009824:Ointments; D010936:Plant Extracts; D009583:Nitrofurazone; D000432:Methanol