Spectrum of neuropsychiatric complications in 791 cases of typhoid fever.
Over a 6-year period, we studied 791 patients with multidrug-resistant typhoid fever, of whom 665 individuals (84%) developed neuropsychiatric manifestations. These were: acute confusional state (73%); myelitis (6%); cerebellitis (1%); parkinsonism (1%); acute psychosis (0.6%); meningo-encephalitis (0.5%); encephalitis (0.25%); sensory motor polyneuropathy, polymyositis, acute schizophrenia and bizarre neurological syndromes (0.12% each). Severe parkinsonian rigidity and meningo-encephalitis are associated with significant morbidity but very low mortality (0.5%).
Ali
G
G
Department of Medicine, Governmental Medical College, SMHS Hospital, Srinagar, India.
Rashid
S
S
Kamli
M A
MA
Shah
P A
PA
Allaqaband
G Q
GQ
D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002526:Cerebellar Diseases / Q000150:complications / Q000175:diagnosis* / Q000453:epidemiology; D003221:Confusion / Q000150:complications / Q000175:diagnosis* / Q000453:epidemiology; D004352:Drug Resistance, Microbial; D018432:Drug Resistance, Multiple; D004660:Encephalitis / Q000150:complications / Q000175:diagnosis* / Q000453:epidemiology; D005260:Female; D006801:Humans; D007194:India / Q000453:epidemiology; D008297:Male; D008590:Meningoencephalitis / Q000150:complications / Q000175:diagnosis* / Q000453:epidemiology; D008875:Middle Aged; D009187:Myelitis / Q000150:complications / Q000175:diagnosis* / Q000453:epidemiology; D010300:Parkinson Disease / Q000150:complications / Q000175:diagnosis* / Q000453:epidemiology; D017285:Polymyositis / Q000150:complications / Q000175:diagnosis* / Q000453:epidemiology; D011618:Psychotic Disorders / Q000150:complications / Q000175:diagnosis* / Q000453:epidemiology; D012559:Schizophrenia / Q000150:complications / Q000175:diagnosis* / Q000453:epidemiology; D014435:Typhoid Fever / Q000150:complications* / Q000188:drug therapy / Q000453:epidemiology
D000900:Anti-Bacterial Agents