title: Uptake of Tc-99m MIBI related to tumour size and type.
abstract: The accuracy of Tc-99m MIBI scintimammography depends on the uptake in cancer cells being greater than surrounding normal tissue. The aim of this study was to determine which were the dominant factors affecting uptake of Tc-99m MIBI in breast cancer cells in vivo. The tumour to background ratio (TBR) was measured in 74 focal breast lumps occurring in 70 women, of whom 53 had breast cancer. In patients with breast cancer the TBR was compared in those under and over 45, those with tumours over and under 20 mm, those who had auxiliary disease, the histological type of the tumour and whether ductal on the Bloom Richardson scale. The only factor which appeared to have an influence on uptake of Tc-99m MIBI was the histological type of the tumour. Ductal carcinomas had a mean TBR of 2.07, significantly greater than either other types of breast cancer (TBR = 1.31) and benign tumours (TBR = 1.46). The histological type of tumour appears to be the dominant factor affecting uptake of Tc99m MIBI in vivo.
authors.affiliation: Department of Nuclear Medicine, Royal Free Hospital and School of Medicine, London, U.K.
authors.forename: J R
authors.initials: JR
authors.lastname: Buscombe
authors.forename: J B
authors.initials: JB
authors.lastname: Cwikla
authors.forename: D S
authors.initials: DS
authors.lastname: Thakrar
authors.forename: A J
authors.initials: AJ
authors.lastname: Hilson
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001692:Biological Transport; D001941:Breast Diseases / Q000000981:diagnostic imaging / Q000473:pathology; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D018270:Carcinoma, Ductal, Breast / Q000000981:diagnostic imaging / Q000473:pathology; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008327:Mammography; D008875:Middle Aged; D011877:Radionuclide Imaging; D017256:Technetium Tc 99m Sestamibi / Q000493:pharmacokinetics
chemical_list: D017256:Technetium Tc 99m Sestamibi