title: Relationship of growth hormone and insulin-like growth factor-1 genotypes with growth and carcass traits in swine.
abstract: The contribution of chromosomal regions linked to growth hormone (GH) and insulin-like growth factor-1 (IGF-1) loci to variation in preweaning average daily gain, postweaning average daily gain (ADG), 10th rib backfat, loin-eye area and muscle pH were evaluated. Offspring of four purebred sires (A-D; n = 150, 195, 148 and 136, respectively) and two cross-bred sires (E and F; n = 157 and 145, respectively) were genotyped initially with GH and IGF-1 markers. When results of single marker analysis suggested possible linkage with a quantitative trait locus (QTL), additional flanking markers were typed for the family and interval mapping was performed. Growth hormone genotype was not associated with the traits evaluated in the study. Evidence suggestive of linkage was found for IGF-1 genotype and ADG in one sire family (lod = 2.3) where differences were 0.032 +/- 0.01 kg/day for alternative sire alleles. Evidence for a putative ADG QTL was greatest in the interval between IGF-1 and Sw1071. A similar genomic region has been associated with growth variation in mice; however, QTL mapping precision in the current study is insufficient to establish similarity.
authors.affiliation: Department of Animal Sciences, University of Wisconsin-Madison 53706, USA.
authors.forename: E
authors.initials: E
authors.lastname: Casas-Carrillo
authors.forename: A
authors.initials: A
authors.lastname: Prill-Adams
authors.forename: S G
authors.initials: SG
authors.lastname: Price
authors.forename: A C
authors.initials: AC
authors.lastname: Clutter
authors.forename: B W
authors.initials: BW
authors.lastname: Kirkpatrick
mesh_terms: D000483:Alleles; D000818:Animals; D001824:Body Constitution / Q000235:genetics; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D005838:Genotype; D013006:Growth Hormone / Q000235:genetics*; D007334:Insulin-Like Growth Factor I / Q000235:genetics*; D008297:Male; D051379:Mice; D012150:Polymorphism, Restriction Fragment Length; D013552:Swine / Q000033:anatomy & histology / Q000235:genetics* / Q000254:growth & development; D015430:Weight Gain / Q000235:genetics
chemical_list: D005819:Genetic Markers; D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone