Increased toxicity of methamphetamine in morphine-dependent mice.
1. The effect of methamphetamine on morphine-dependent mice was investigated by calculating the LD50 (i.p.), measuring motor activity, anorectic actions, and body temperature. 2. Methamphetamine was more toxic in morphine-dependent mice (LD50 = 20.6 mg/kg) than in normal mice (LD50 = 43.2 mg/kg). 3. Methamphetamine-induced locomotor activity was greater in morphinized than in nonmorphinized mice at doses of 2.5 and 5 mg/kg i.p. 4. Methamphetamine also increased the body temperature of morphinized mice more than that of normal mice (P < 0.05). 5. These findings suggest that methamphetamine is more toxic in morphine-dependent than in nondependent mice.
Ginawi
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Department of Pharmacology, College of Pharmacy, King Saud University, Riyadh, Kingdom of Saudi Arabia.
al-Shabanah
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OA
Bakheet
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SA
D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D000697:Central Nervous System Stimulants / Q000633:toxicity*; D004347:Drug Interactions; D005247:Feeding Behavior / Q000187:drug effects; D007928:Lethal Dose 50; D008297:Male; D008694:Methamphetamine / Q000633:toxicity*; D051379:Mice; D009020:Morphine / Q000494:pharmacology*; D009021:Morphine Dependence / Q000503:physiopathology*; D009043:Motor Activity / Q000187:drug effects; D009294:Narcotics / Q000494:pharmacology*
D000697:Central Nervous System Stimulants; D009294:Narcotics; D008694:Methamphetamine; D009020:Morphine