title: Sch 54445: a new polycyclic xanthone with highly potent antifungal activity produced by Actinoplanes sp.
abstract: A novel antifungal agent, Sch 54445, was isolated from the fermentation broth of an Actinoplanes species. Sch 54445 was identified as a polycyclic xanthone related to the albofungin family of compounds on the basis of analyses of spectroscopic data. As a broad-spectrum antifungal agent, Sch 54445 exhibits highly potent activities against various yeasts and dermatophytes with MIC values approximately 0.00038 microgram/mL.
authors.affiliation: Schering-Plough Research Institute, Kenilworth, New Jersey 07003, USA.
authors.forename: M
authors.initials: M
authors.lastname: Chu
authors.forename: I
authors.initials: I
authors.lastname: Truumees
authors.forename: R
authors.initials: R
authors.lastname: Mierzwa
authors.forename: J
authors.initials: J
authors.lastname: Terracciano
authors.forename: M
authors.initials: M
authors.lastname: Patel
authors.forename: D
authors.initials: D
authors.lastname: Loebenberg
authors.forename: J J
authors.initials: JJ
authors.lastname: Kaminski
authors.forename: P
authors.initials: P
authors.lastname: Das
authors.forename: M S
authors.initials: MS
authors.lastname: Puar
mesh_terms: D000192:Actinomycetales / Q000378:metabolism*; D000935:Antifungal Agents / Q000096:biosynthesis / Q000302:isolation & purification / Q000494:pharmacology*; D002240:Carbohydrate Sequence; D005285:Fermentation; D005658:Fungi / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D008969:Molecular Sequence Data; D014966:Xanthenes / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology*
chemical_list: D000935:Antifungal Agents; C106397:Sch 54445; D014966:Xanthenes