Animal membrane receptors and adhesive molecules.
This review summarizes some important data, principles, opinions, commentaries, and modern methodology concerning the receptor structure, interactions, signaling and receptor-mediated cell functions. Three sections give a brief overview of the signaling synergy, multivariant signaling, and some reactions in phosphorylation networks. A concise report about the cytotoxic reaction of NK cells represents an example of multistage recognition reaction, involving differently acting receptors, changes in affinities of cell-cell interactions, and secretion of regulatory and cytotoxic molecules. Some interesting trends in receptor engineering, including antibody molecules as a special receptor phenomenon are mentioned in the final section.
Kubrycht
J
J
Department of Immunology, Czech Academy of Sciences, Prague, Czech Republic.
Sigler
K
K
D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D001709:Biotechnology / Q000639:trends; D015815:Cell Adhesion Molecules / Q000737:chemistry / Q000378:metabolism* / Q000502:physiology; D002450:Cell Communication / Q000502:physiology; D005818:Genetic Engineering / Q000639:trends; D006801:Humans; D007694:Killer Cells, Natural / Q000166:cytology / Q000502:physiology; D008024:Ligands; D008214:Lymphocytes / Q000166:cytology / Q000502:physiology; D008969:Molecular Sequence Data; D010766:Phosphorylation; D011956:Receptors, Cell Surface / Q000737:chemistry / Q000378:metabolism* / Q000502:physiology; D016028:Receptors, Leukocyte-Adhesion / Q000378:metabolism; D018271:Signal Recognition Particle / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology
D015815:Cell Adhesion Molecules; D008024:Ligands; D011956:Receptors, Cell Surface; D016028:Receptors, Leukocyte-Adhesion; D018271:Signal Recognition Particle