Dual role of testosterone in fenvalerate-treated mice with respect to thyroid function and lipid peroxidation.
Effects of testosterone propionate (TP, 2.5 mg kg(-1) body weight) in fenvalerate-induced (120 mg kg(-1) body weight) thyroid dysfunction and lipid peroxidation were investigated in male mice. Testosterone propionate aggravated in the inhibition of hepatic type I iodothyronine 5'-monodeiodinase (5'D-I) activity, coupled with a decrease in serum triiodothyronine (T3) concentration in pesticide-treated mice. However, it could ameliorate the toxicity as indicated by decreased hepatic lipid peroxidation (LPO) with a marginal but significant increase in superoxide dismutase and catalase activities following fenvalerate treatment. While protective effects of testosterone on LPO indicated its antiperoxidative property, the decrease in 5'D-I activity could be because of the increased accumulation of fenvalerate in the tissues following TP administration.
Maiti
P K
PK
Thyroid Research Unit, School of Life Sciences, Devi Ahilya University, Vigyan Bhawan, Indore, India.
Kar
A
A
D000818:Animals; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D051379:Mice; D009570:Nitriles; D011722:Pyrethrins / Q000494:pharmacology*; D013739:Testosterone / Q000494:pharmacology*; D013960:Thyroid Function Tests; D013961:Thyroid Gland / Q000187:drug effects*
D004791:Enzyme Inhibitors; D009570:Nitriles; D011722:Pyrethrins; D013739:Testosterone; C017690:fenvalerate