title: [Activation of proto-oncogene c-fos in the auditory tract of rats stimulation with wide-band noise].
abstract: The pattern of expression of the proto-oncogene c-fos was mapped in the auditory pathway of Wistar rats kept in three different experimental conditions: a) a dark, soundproofed room; b) with exposure to usual environmental laboratory noise, and c) with exposure to wide-band noise. Under control conditions (a and b), scattered labeled neurons were found in the ventral periolivary nucleus, lateral lemniscus nuclei, inferior colliculus, medial nucleus of the medial geniculate body, and in three divisions of the temporal auditory cortex. Sound stimulation (c) increased the number of fos-like-immunoreactive (FLI) nuclei in all the auditory pathway structures. FLI nuclei were strong in the dorsal cochlear nucleus, anterior and posterior ventral cochlear nuclei, all the superior olivary complex nuclei, lateral lemniscus nuclei, all areas of the inferior colliculus, medial geniculate body, and the three temporal auditory areas, which showed a barrel pattern. Comparison of these results with the literature indicated that fos activation is not merely a sign of transitory neural activation, but a long-term neural processing pathway that is conditioned by factors such as the frequency, intensity, duration, and direction of the auditory stimulus.
authors.affiliation: Departamento Ciencias Morfológicas, Facultad de Medicina y Odontología, Universidad de Valencia.
authors.forename: F E
authors.initials: FE
authors.lastname: Olucha
authors.forename: A
authors.initials: A
authors.lastname: Molina Mira
authors.forename: C
authors.initials: C
authors.lastname: Valenzuela Méndez
authors.forename: A A
authors.initials: AA
authors.lastname: Valverde Navarro
authors.forename: F
authors.initials: F
authors.lastname: Martínez Soriano
mesh_terms: D000161:Acoustic Stimulation; D000818:Animals; D001306:Auditory Pathways / Q000276:immunology; D017626:Cochlear Nucleus / Q000648:ultrastructure; D005260:Female; D007245:Inferior Colliculi / Q000648:ultrastructure; D008297:Male; D009622:Noise; D011519:Proto-Oncogenes / Q000276:immunology*; D051381:Rats; D017208:Rats, Wistar