title: Influence of copper on MRI of hepatocellular carcinoma.
abstract: The purpose of this paper is to clarify whether copper accumulation in hepatocellular carcinoma (HCC) is a cause of high intensity signal pattern on T1-weighted images (T1-WI) by comparing the histologically proven copper accumulation with MR images. Forty-five surgically resected HCCs were analyzed. Distribution patterns of divalent copper by a modified Timm's method on their maximum cut surfaces were compared with signal patterns on corresponding T1-WI. The degree of copper accumulation in tumor compared with surrounding liver tissue was higher in 6 lesions, equal in 17 lesions, and lower in 22 lesions. High intensity pattern on T1-WI were observed in 3 of 6 lesions (50%), 10 of 17 lesions (59%), and 10 of 22 lesions (45%). Distribution patterns of copper were not correlated with intensity patterns on T1-WI. We conclude that the paramagnetic effect of divalent copper accumulation in HCC is insufficient to influence the MRI.
authors.affiliation: Department of Radiology, University of Tokushima, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Matsuzaki
authors.forename: N
authors.initials: N
authors.lastname: Sano
authors.forename: N
authors.initials: N
authors.lastname: Hashiguchi
authors.forename: S
authors.initials: S
authors.lastname: Yoshida
authors.forename: H
authors.initials: H
authors.lastname: Nishitani
mesh_terms: D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000737:chemistry / Q000175:diagnosis*; D003300:Copper / Q000032:analysis*; D046508:Culture Techniques; D003937:Diagnosis, Differential; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000737:chemistry / Q000175:diagnosis*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D012680:Sensitivity and Specificity
chemical_list: D003300:Copper