title: Anti-oxidative therapy with oral dapsone improved HCV antibody positive annular elastolytic giant cell granuloma.
abstract: A 72-year-old fisherman who was positive for the HCV antibody developed an annular, erythematous, infiltrated lesions on sun-exposed areas. The lesions were diagnosed as annular elastolytic giant cell granuloma both clinically and histologically. Topical corticosteroid and cryotherapy with liquid nitrogen for several months failed to improve the lesions. We then started dapsone, a known anti-oxidant, at 50 mg/day. A month later, the margins of the erythematous lesions faded, and the infiltration gradually decreased. No recurrence has been observed for one year after the start of the therapy. Anti-oxidative therapy appears to be effective for annular elastolytic giant cell granuloma and could be an alternate therapy for refractory granulomatous disease.
authors.affiliation: Department of Dermatology, Tokyo Medical and Dental University School of Medicine, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Igawa
authors.forename: R
authors.initials: R
authors.lastname: Maruyama
authors.forename: I
authors.initials: I
authors.lastname: Katayama
authors.forename: K
authors.initials: K
authors.lastname: Nishioka
mesh_terms: D000284:Administration, Oral; D000368:Aged; D000975:Antioxidants / Q000627:therapeutic use*; D003622:Dapsone / Q000627:therapeutic use*; D004547:Elastic Tissue / Q000187:drug effects / Q000473:pathology; D005493:Folic Acid Antagonists / Q000627:therapeutic use*; D016460:Granuloma Annulare / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D006101:Granuloma, Giant Cell / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D016174:Hepacivirus / Q000276:immunology; D006526:Hepatitis C / Q000150:complications*; D018937:Hepatitis C Antibodies / Q000276:immunology*; D006801:Humans; D008297:Male; D012871:Skin Diseases / Q000150:complications / Q000188:drug therapy* / Q000473:pathology
chemical_list: D000975:Antioxidants; D005493:Folic Acid Antagonists; D018937:Hepatitis C Antibodies; D003622:Dapsone