title: Wheezing bronchitis reinvestigated at the age of 10 years.
abstract: We have reinvestigated 92/101 children aged 10, who before the age of 2 years were admitted to a paediatric ward due to wheezing bronchitis. At the present time, 70% are symptom-free without medication, 20% have mild asthma, 8% moderate and 2% severe asthma. Persistent asthma correlated significantly to the presence of some other atopic disease in recent years, to early start of wheezing during infancy and to intense obstructive disease as a young child, while initial respiratory syncytial virus infection did not. A clear-cut relationship between smoking in the home in infancy and persistent asthma emerged (not visible at a preschool follow-up). The histamine challenge results correlated to the clinical picture. A normal histamine challenge was seen in 63%, mild hyperresponsiveness in 19%, moderate in 12% and pronounced hyperresponsiveness in 6%. The figures for persistent asthma and bronchial hyperresponsiveness are high compared with the prevalence of asthma in the overall population of schoolchildren.
authors.affiliation: Department of Paediatrics, Ostra University Hospital, Göteborg, Sweden.
authors.forename: G
authors.initials: G
authors.lastname: Wennergren
authors.forename: M
authors.initials: M
authors.lastname: Amark
authors.forename: K
authors.initials: K
authors.lastname: Amark
authors.forename: S
authors.initials: S
authors.lastname: Oskarsdóttir
authors.forename: G
authors.initials: G
authors.lastname: Sten
authors.forename: S
authors.initials: S
authors.lastname: Redfors
mesh_terms: D001249:Asthma / Q000453:epidemiology* / Q000209:etiology; D001991:Bronchitis / Q000150:complications / Q000453:epidemiology* / Q000821:virology; D005500:Follow-Up Studies; D006632:Histamine; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000453:epidemiology / Q000209:etiology; D007223:Infant; D012135:Respiratory Sounds / Q000209:etiology; D018357:Respiratory Syncytial Virus Infections / Q000150:complications / Q000453:epidemiology; D012189:Retrospective Studies; D012720:Severity of Illness Index; D013548:Sweden / Q000453:epidemiology; D014028:Tobacco Smoke Pollution / Q000009:adverse effects
chemical_list: D014028:Tobacco Smoke Pollution; D006632:Histamine