title: Modulation of 6-hydroxydopamine oxidation by various proteins.
abstract: The spontaneous autoxidation of the neurotoxin 6-hydroxydopamine proceeds by a free radical chain reaction involving the superoxide anion radical and produces the corresponding chromogen 6-hydroxydopamine quinone and hydrogen peroxide. The rate of this reaction is increased in the presence of ceruloplasmin and peroxidase, and reduced by superoxide dismutase, catalase, and DT-diaphorase. We report some explanations of why these proteins may increase or reduce the rate of autoxidation of 6-hydroxydopamine.
authors.affiliation: Institute of Biological Chemistry, University of Cagliari, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Padiglia
authors.forename: R
authors.initials: R
authors.lastname: Medda
authors.forename: A
authors.initials: A
authors.lastname: Lorrai
authors.forename: G
authors.initials: G
authors.lastname: Biggio
authors.forename: E
authors.initials: E
authors.lastname: Sanna
authors.forename: G
authors.initials: G
authors.lastname: Floris
mesh_terms: D000818:Animals; D002374:Catalase / Q000378:metabolism; D002570:Ceruloplasmin / Q000378:metabolism; D008058:Dihydrolipoamide Dehydrogenase / Q000378:metabolism; D007700:Kinetics; D009498:Neurotoxins / Q000378:metabolism*; D010084:Oxidation-Reduction; D016627:Oxidopamine / Q000737:chemistry / Q000378:metabolism*; D010100:Oxygen / Q000378:metabolism; D009195:Peroxidase / Q000378:metabolism; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D009498:Neurotoxins; D016627:Oxidopamine; D002374:Catalase; D009195:Peroxidase; D013482:Superoxide Dismutase; D002570:Ceruloplasmin; D008058:Dihydrolipoamide Dehydrogenase; D010100:Oxygen