Zinc finger-like motif conserved in a family of RNA binding proteins.
NP220s compose a family of RNA binding proteins together with matrin 3, one of major proteins of the nuclear matrix. They have repeats of RNA recognition motif (RRM; MH2) homologous to RRM in heterogeneous nuclear RNPs I/L in addition to MH1 and MH3 with unknown function. In search of additional homologous sequences, we found the reported sequence of rat matrin 3 is partially incorrect. Correction of this sequence showed that the NP220 family has a fourth homologous motif with the characteristics of a Cys2-His2 zinc finger-like motif. The sequence of this motif is perfectly conserved in human and mouse NP220s despite their 75% overall sequence homology.
Matsushima
Y
Y
Graduate Program of Biochemical Regulation, School of Agricultural Sciences, Nagoya University, Japan.
Matsumura
K
K
Kitagawa
Y
Y
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D017124:Conserved Sequence; D006801:Humans; D051379:Mice; D008969:Molecular Sequence Data; D005810:Multigene Family; D016601:RNA-Binding Proteins / Q000235:genetics*; D051381:Rats; D017207:Rats, Sprague-Dawley; D017386:Sequence Homology, Amino Acid; D014407:Tumor Cells, Cultured; D016335:Zinc Fingers / Q000235:genetics*
D016601:RNA-Binding Proteins