title: A pilot study of the effect of the glycosaminoglycan sulodexide on microalbuminuria in type I diabetic patients.
abstract: Fifteen out-patients with type I diabetes mellitus and microalbuminuria (mean +/- SEM: 95.4 +/- 13.9 micrograms/min), were administered the glycosaminoglycan sulodexide, with the aim of investigating its influence on the rate of albumin excretion. Sulodexide was given intramuscularly in a dose of 600 lipoproteinlipase releasing units/day for three weeks. Albumin excretion was measured before dosing, at weekly intervals during dosing and also during the subsequent follow-up period of six weeks. Sulodexide yielded a clear-cut and statistically significant lowering of albumin excretion after the first week of treatment (from 95.4 +/- 13.9 micrograms/min to 53.6 +/- 11.1 micrograms/min; p = 0.0055); albumin excretion was further decreased after three weeks of treatment (26.5 +/- 6.05 micrograms/min; p = 0.0007) and was maintained during the follow-up period, at the end of which the mean value was still significantly lower than at baseline (39.6 +/- 10.3 micrograms/min; p = 0.01). Sulodexide short-term administration did not influence the routine haematological, haematochemical and coagulative tests performed contemporaneously. Patients' compliance with treatment was very good and no adverse events were reported.
authors.affiliation: Clinic of Endocrinology, Medical Academy Bialystok, Poland.
authors.forename: M
authors.initials: M
authors.lastname: Szelachowska
authors.forename: A
authors.initials: A
authors.lastname: Poplawska
authors.forename: J
authors.initials: J
authors.lastname: Topolska
authors.forename: I
authors.initials: I
authors.lastname: Kinalska
authors.forename: M
authors.initials: M
authors.lastname: Grimaldi
authors.forename: M
authors.initials: M
authors.lastname: Szelanowska
authors.forename: J
authors.initials: J
authors.lastname: Jopdska
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000419:Albuminuria / Q000188:drug therapy*; D003922:Diabetes Mellitus, Type 1 / Q000188:drug therapy*; D005260:Female; D006025:Glycosaminoglycans / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007273:Injections, Intramuscular; D008297:Male; D008875:Middle Aged; D010349:Patient Compliance; D010865:Pilot Projects
chemical_list: D006025:Glycosaminoglycans; C007858:glucuronyl glucosamine glycan sulfate