title: Conditioned defensive reflex in the edible snail (molecular-genetic aspects).
abstract: The expression of the early genes c-fos and c-jun were studied by blot hybridization in the central nervous system of the edible snail at the consolidation stage of a conditioned defensive reflex, with the aim of investigating genomic activity in neurons during learning. The c-fos gene was shown to be present in the Helix central nervous system, and its expression was shown to increase significantly during learning. Superinduction of the c-fos gene was observed in the presence of cycloheximide, a protein synthesis inhibitor. Corasol also induced this gene. Thus, induction of the c-fos gene in Helix can be induced by agents which induce it in higher vertebrates. This suggests that expression of the c-fos gene in Helix and in higher vertebrates is regulated by closely related mechanisms. Expression of the c-jun gene was insignificant, and definitive conclusions with regard to the role of this gene in learning cannot be drawn.
authors.affiliation: Department of Medical Informatics and Electronics, Russian Academy of Sciences, Novosibirsk.
authors.forename: L N
authors.initials: LN
authors.lastname: Grinkevich
authors.forename: I N
authors.initials: IN
authors.lastname: Nagibneva
authors.forename: P D
authors.initials: PD
authors.lastname: Lisachev
mesh_terms: D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects / Q000502:physiology; D003214:Conditioning, Classical / Q000502:physiology*; D003513:Cycloheximide / Q000494:pharmacology; D004597:Electroshock; D005502:Food; D015870:Gene Expression / Q000187:drug effects / Q000502:physiology; D017781:Genes, Immediate-Early / Q000235:genetics* / Q000502:physiology*; D016762:Genes, fos; D016758:Genes, jun; D006372:Helix, Snails / Q000502:physiology*; D017403:In Situ Hybridization; D009473:Neuronal Plasticity / Q000187:drug effects / Q000502:physiology; D011500:Protein Synthesis Inhibitors / Q000494:pharmacology; D011803:Quinine / Q000494:pharmacology; D012313:RNA / Q000096:biosynthesis
chemical_list: D011500:Protein Synthesis Inhibitors; D012313:RNA; D003513:Cycloheximide; D011803:Quinine