Mycophenolate mofetil and prednisone as maintenance treatment after kidney transplantation.
BACKGROUND
Hemolytic uremic syndrome (HUS) is an infrequent but severe complication of kidney transplantation. Cyclosporine-induced microangiopathy may be the causative factor in allograft recipients with HUS. In transplant recipients with HUS, discontinuation of cyclosporine is generally advised. This often leads to loss of the graft.


METHODS
An adult kidney transplant recipient developed HUS in the third week after transplantation. Maintenance immunosuppression was changed to mycophenolate mofetil and prednisone after cyclosporine was discontinued.


RESULTS
The change in immunosuppressive therapy led to remission of the HUS and stable graft function.


CONCLUSIONS
In transplant recipients receiving cyclosporine who suffer from HUS, the possibility of conversion from cyclosporine to mycophenolate mofetil should be considered. As this case shows, complete remission of HUS and maintenance of the graft are possible.
van Gelder
T
T
Department of Internal Medicine I, University Hospital Rotterdam, The Netherlands.
Klaassen
R J
RJ
van Riemsdijk-van Overbeeke
I
I
IJzermans
J N
JN
Weimar
W
W
D005260:Female; D006084:Graft Rejection / Q000517:prevention & control; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D016030:Kidney Transplantation / Q000276:immunology*; D008875:Middle Aged; D009173:Mycophenolic Acid / Q000031:analogs & derivatives; D011241:Prednisone / Q000627:therapeutic use*
D007166:Immunosuppressive Agents; D009173:Mycophenolic Acid; D011241:Prednisone