Rolling in the clover: trefoil factor family (TFF)-domain peptides, cell migration and cancer.
Trefoil factor family (TFF)-domain peptides 1-3 are mucin-associated molecules, largely found in epithelia of gastrointestinal tissues. Structurally similar, resistant to enzymatic degradation, they are up-regulated around areas of epithelial damage such as ulcers. Transgenic expression or exogenous peptide ameliorates or prevents gastric mucosal damage due to indomethacin and some are rapidly up-regulated after cryogenic burns. A role in promoting cell migration is strongly suggested. Knockout mice lacking TFF1 or TFF3 show significant pathology, with the former developing gastric tumours. A recent Conference Philippe Laudat agreed upon a new nomenclature for these peptides.
Wright
N A
NA
Histopathology Unit, Imperial Cancer Research Fund, London, UK. nwright@rpms.ac.uk
Hoffmann
W
W
Otto
W R
WR
Rio
M C
MC
Thim
L
L
D000818:Animals; D002465:Cell Movement; D016384:Consensus Sequence; D005770:Gastrointestinal Neoplasms / Q000209:etiology* / Q000473:pathology; D006133:Growth Substances / Q000737:chemistry / Q000378:metabolism*; D007213:Indomethacin / Q000633:toxicity; D007413:Intestinal Mucosa / Q000737:chemistry / Q000166:cytology / Q000378:metabolism*; D051379:Mice; D018345:Mice, Knockout; D009077:Mucins; D009124:Muscle Proteins; D009479:Neuropeptides / Q000737:chemistry / Q000378:metabolism; D010455:Peptides / Q000737:chemistry / Q000378:metabolism*; D009626:Terminology as Topic; D000071164:Trefoil Factor-2; D000071165:Trefoil Factor-3
D006133:Growth Substances; D009077:Mucins; D009124:Muscle Proteins; D009479:Neuropeptides; D010455:Peptides; C099037:TFF3 protein, rat; D000071164:Trefoil Factor-2; D000071165:Trefoil Factor-3; D007213:Indomethacin