title: A fatal case of betaxolol poisoning.
abstract: We report the first case in the literature of fatal betaxolol (Kerlone) self-poisoning. After a single-step liquid-liquid alkaline extraction, betaxolol was identified by a high-performance liquid chromatographic-diode array detection screening procedure and then quantitated in cardiac blood, heart, brain, muscle, spleen, stomach contents, duodenum contents, liver, and kidney. The blood betaxolol concentration was 36 mg/L.
authors.affiliation: Institut de Médecine Légale, Strasbourg, France.
authors.forename: F
authors.initials: F
authors.lastname: Berthault
authors.forename: P
authors.initials: P
authors.lastname: Kintz
authors.forename: A
authors.initials: A
authors.lastname: Tracqui
authors.forename: P
authors.initials: P
authors.lastname: Mangin
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000097:blood / Q000378:metabolism / Q000506:poisoning*; D000328:Adult; D001344:Autopsy; D015784:Betaxolol / Q000097:blood / Q000378:metabolism / Q000506:poisoning*; D001921:Brain / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D005260:Female; D005766:Gastrointestinal Contents / Q000737:chemistry; D006801:Humans; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D009132:Muscles / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D012015:Reference Standards; D013154:Spleen / Q000378:metabolism; D013405:Suicide; D014018:Tissue Distribution
chemical_list: D000319:Adrenergic beta-Antagonists; D015784:Betaxolol