[The inductive immunosuppressive activity of the nonspecific lipopolysaccharide fraction of virulent Shigella sonnei].
The influence of lipopolysaccharide (LPS) fraction (molecular weight 50-70 kD) of virulent Shigella sonnei on bacterium ability to suppress delayed-type hypersensitivity (DTH) to xenogenic test-antigen in mice has been studied. It is found that single injection of LPS-fraction or bacteria does not inhibit DTH. Intraperitoneal injection of LPS-fraction together with avirulent S. sonnei causes DTH inhibition in mice and at the same time the injection of LPS-fraction together with Staphylococcus or Pseudomonas (extracellular parasites) does not render influence on DTH levels. There is a possibility of LPS-fraction conversion from active to non-active state and back after treatment by trichloracetic acid, phenol or redox system. It is assumed that in Shigella sonnei infection avirulent enteroinvasive bacteria can be involved in immunopathological process due to activity of non-specific fraction of S. sonnei LPS.
Borisova
E V
EV
Borisov
V A
VA
D000818:Animals; D004926:Escherichia coli / Q000276:immunology / Q000472:pathogenicity; D006168:Guinea Pigs; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007108:Immune Tolerance / Q000276:immunology*; D008070:Lipopolysaccharides / Q000276:immunology*; D051379:Mice; D008808:Mice, Inbred CBA; D011550:Pseudomonas aeruginosa / Q000276:immunology / Q000472:pathogenicity; D012475:Salmonella / Q000276:immunology / Q000472:pathogenicity; D012764:Shigella sonnei / Q000276:immunology* / Q000472:pathogenicity; D013211:Staphylococcus aureus / Q000276:immunology / Q000472:pathogenicity; D014774:Virulence / Q000276:immunology
D008070:Lipopolysaccharides