title: Determination of piracetam in human plasma by capillary electrophoresis.
abstract: A capillary electrophoresis (CE) procedure has been developed for the determination of piracetam in human plasma. Analyses were performed on an uncoated silica capillary using borax buffer modified with the addition of alpha-cyclodextrin. The detection was UV, operated at 200 nm. The detection limit of the authentic samples was 1 microg/ml. The calibration curve was linear over a range of 4 to 24 microg/ml (r=0.997). Inter-assay R.S.D. was below 9.3%. The described method has been successfully applied to the quantitative determination of piracetam in human plasma and should be useful for clinical and bioavailability investigations.
authors.affiliation: Medical University of Gdañsk, Faculty of Pharmacy, Hallera, Poland.
authors.forename: H
authors.initials: H
authors.lastname: Lamparczyk
authors.forename: P
authors.initials: P
authors.lastname: Kowalski
authors.forename: D
authors.initials: D
authors.lastname: Rajzer
authors.forename: J
authors.initials: J
authors.lastname: Nowakowska
mesh_terms: D019075:Electrophoresis, Capillary / Q000379:methods*; D006801:Humans; D018697:Nootropic Agents / Q000097:blood*; D010889:Piracetam / Q000097:blood*; D012015:Reference Standards; D013056:Spectrophotometry, Ultraviolet
chemical_list: D018697:Nootropic Agents; D010889:Piracetam