title: A three center study on the diagnostic accuracy of 99mTc-MIBI scintimammography.
abstract: In order to assess specificity and sensitivity of the prone scintimammography (PSM) in a large series with 99m-Tc MIBI, we performed a three-center study; 420 patients were studied; after mammography all the patients were submitted to PSM and biopsy and/or operation. PSM was considered positive if hot spot within the breast was observed. In palpable masses sensitivity was 0.98 and specificity 0.89, non palpable masses showed a sensitivity of 0.62 and a specificity of 0.91. When the cancers were stratified for T category the sensitivity was 0.28 in T1a 0.26 in the group of T1a carcinomas, 0.56 in T1b 0.95 in T1c and 0.97 T2 tumors. Physical factors such as attenuation. Compton scattering from chest, as well as biological factors have a role in breast tumor imaging. In the tumors smaller than 1 cm biological factors are probably involved too.
authors.affiliation: Department of Experimental Medicine, University La Sapienza, Rome, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Scopinaro
authors.forename: O
authors.initials: O
authors.lastname: Schillaci
authors.forename: W
authors.initials: W
authors.lastname: Ussof
authors.forename: K
authors.initials: K
authors.lastname: Nordling
authors.forename: R
authors.initials: R
authors.lastname: Capoferro
authors.forename: G
authors.initials: G
authors.lastname: De Vincentis
authors.forename: R
authors.initials: R
authors.lastname: Danieli
authors.forename: M
authors.initials: M
authors.lastname: Ierardi
authors.forename: V
authors.initials: V
authors.lastname: Picardi
authors.forename: R
authors.initials: R
authors.lastname: Tavolaro
authors.forename: A C
authors.initials: AC
authors.lastname: Colella
mesh_terms: D000328:Adult; D000368:Aged; D001706:Biopsy; D001941:Breast Diseases / Q000000981:diagnostic imaging*; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D005188:False Negative Reactions; D005189:False Positive Reactions; D005260:Female; D006801:Humans; D008327:Mammography; D008875:Middle Aged; D009367:Neoplasm Staging; D011237:Predictive Value of Tests; D011877:Radionuclide Imaging; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D017256:Technetium Tc 99m Sestamibi
chemical_list: D017256:Technetium Tc 99m Sestamibi