Toward a novel metal-based chemotherapy against tropical diseases. 3. Synthesis and antimalarial activity in vitro and in vivo of the new gold-chloroquine complex [Au(PPh3)(CQ)]PF6.
Navarro
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M
Transition Metal Chemistry and Immunoparasitology Laboratories, Instituto Venezolano de Investigaciones Cientificas (IVIC), Caracas, Venezuela.
Pérez
H
H
Sánchez-Delgado
R A
RA
D000818:Animals; D000962:Antimalarials / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D002738:Chloroquine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology / Q000627:therapeutic use; D004351:Drug Resistance; D005260:Female; D008288:Malaria / Q000188:drug therapy; D051379:Mice; D008807:Mice, Inbred BALB C; D015394:Molecular Structure; D050607:Organogold Compounds; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D010962:Plasmodium berghei / Q000187:drug effects*; D010963:Plasmodium falciparum / Q000187:drug effects*
D000962:Antimalarials; D050607:Organogold Compounds; D009942:Organometallic Compounds; C106604:chloroquine(triphenylphosphine)gold(I); D002738:Chloroquine