RNA editing and hypermutation by adenosine deamination.
Double-stranded RNA adenosine deaminase (dsRAD) was discovered ten years ago. In the intervening decade, research on dsRAD has progressed not only predictably, such as with the purification of the enzyme and identification of cDNAs, but also in some quite surprising ways. This review covers both areas of progress, but will concentrate on the surprises, which include the discovery that dsRAD is a member of a larger family of deaminases and the identification of RNAs that appear to be targets for these deaminases in vivo.
Bass
B L
BL
Department of Biochemistry, University of Utah, Salt Lake City 84112, USA. bass@msscc.med.utah.edu
D000243:Adenosine Deaminase / Q000378:metabolism*; D000818:Animals; D001483:Base Sequence; D018076:DNA, Complementary; D003698:Hepatitis Delta Virus / Q000235:genetics; D008969:Molecular Sequence Data; D009154:Mutation; D012313:RNA / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D017393:RNA Editing; D012367:RNA, Viral; D017470:Receptors, Glutamate / Q000235:genetics
D018076:DNA, Complementary; D012367:RNA, Viral; D017470:Receptors, Glutamate; D012313:RNA; D000243:Adenosine Deaminase