Laminin-binding proteins in EJ-ras-transformed fibroblasts.
Malignant transformation is accompanied by changes in cell-matrix interactions. Upon transfection with EJ-ras oncogene, transformed fibroblasts acquired a migratory phenotype towards laminin-1. The increase in integrin expression was responsible for the migratory activity of transformed fibroblasts. In addtion alpha 6 beta 1 integrins, both galectin-3 and an unidentified laminin-binding polypeptide had their expression pattern altered upon transformation. Here, we review these two classes of laminin-binding proteins and their possible roles in cell-laminin interactions.
Chammas
R
R
Ludwig Institute for Cancer Research, São Paulo, Brasil. rchammas@ucsd.edu
Jasiulionis
M G
MG
Ventura
A M
AM
Travassos
L R
LR
Brentani
R R
RR
D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D005347:Fibroblasts / Q000276:immunology*; D011905:Genes, ras / Q000235:genetics*; D006801:Humans; D007797:Laminin / Q000276:immunology*; D037102:Lectins / Q000276:immunology*; D015674:Mammary Neoplasms, Animal / Q000276:immunology*; D009857:Oncogenes / Q000276:immunology
D007797:Laminin; D037102:Lectins