Antiinflammatory activities of procyanidin-containing extracts from Pinus pinaster Ait. after oral and cutaneous application.
Orally in liquid diet administered procyanidin-containing extracts from Pinus pinaster Ait. decreased the croton oil-induced ear edema in mice or the compound 48/80-induced hind paw edema in rats to a statistically significant extent. Most effective were the extracts containing mainly oligomeric procyanidins with chain lengths greater then 4 units (extracts A or B). Further, the different extracts incorporated in various concentrations (1.0, 3.0 or 0.1%) in 5% hydroxyethylcellulose gel and applied topically on the shaved back of rats, inhibited significantly the ultraviolet radiation-induced increased capillary permeability. In these experiments, normalisation of capillary permeability was not correlated with the content of the extracts on higher oligomeric procyanidins.
Blazsó
G
G
Institute of Pharmacodynamics, Albert Szent-Györgyi Medical University, Szeged, Hungary.
Gábor
M
M
Rohdewald
P
P
D000284:Administration, Oral; D000287:Administration, Topical; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000494:pharmacology*; D044946:Biflavonoids; D002199:Capillary Permeability / Q000187:drug effects; D002392:Catechin / Q000008:administration & dosage / Q000494:pharmacology*; D003436:Croton Oil; D003879:Dermatologic Agents; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control; D005260:Female; D051379:Mice; D008815:Mice, Inbred Strains; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology*; D044945:Proanthocyanidins; D051381:Rats; D017207:Rats, Sprague-Dawley; D014466:Ultraviolet Rays; D003189:p-Methoxy-N-methylphenethylamine
D000894:Anti-Inflammatory Agents, Non-Steroidal; D044946:Biflavonoids; D003879:Dermatologic Agents; D010936:Plant Extracts; D044945:Proanthocyanidins; D003189:p-Methoxy-N-methylphenethylamine; C017674:procyanidin; D003436:Croton Oil; D002392:Catechin