Widespread neuronal expression of c-Fos throughout the brain and local expression in glia following a hippocampal injury.
Fos oncoprotein is an immediate early gene product and a marker of cell activation following a variety of insults. We have previously shown that a mechanical lesion to the hippocampus of adult mice induces a neuronal expression of the cytokines interleukin-1alpha (IL-1alpha) and tumor necrosis factor-alpha (TNF alpha) whereas a lesion to the striatum does not. The role of these inflammatory cytokines in the pathophysiology of central neurons is still unclear. The present work was undertaken to study a possible correlation between the central expression patterns of c-Fos on the one hand and IL-1alpha and TNF alpha on the other hand. We show that Fos is expressed in a majority of brain neurons after a unilateral lesion to the hippocampus whereas it is confined to the site of injury when applied to the striatum, as previously described for the expression of the cytokines.
Tchélingérian
J L
JL
INSERM U-134, Hôpital de la Salpêtrière, Paris, France.
Le Saux
F
F
Pouzet
B
B
Jacque
C
C
D000818:Animals; D001921:Brain / Q000166:cytology / Q000378:metabolism*; D001931:Brain Mapping / Q000379:methods; D006624:Hippocampus / Q000293:injuries* / Q000378:metabolism / Q000473:pathology; D051379:Mice; D008810:Mice, Inbred C57BL; D009419:Nerve Tissue Proteins / Q000096:biosynthesis*; D009457:Neuroglia / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism*; D016760:Proto-Oncogene Proteins c-fos / Q000096:biosynthesis*; D012016:Reference Values
D009419:Nerve Tissue Proteins; D016760:Proto-Oncogene Proteins c-fos