title: Cardiorespiratory effects of L-glutamate microinjected into the rat ventral medulla.
abstract: We investigated the cardiorespiratory effects elicited by microinjections of L-glutamate (L-glu, 25 nmol, 200 nl) at various sites in the ventral medulla (VMS) of urethane-anesthetized rats. The results demonstrated that regions responsive to the drug are located along a column in the VMS extending from the VI cranial nerve to the first cervical nerve in the caudal medulla. Within this column three breathing patterns were elicited from four distinct areas. In the most rostral and caudal portion of this hypothetical column, the breathing patterns observed in response to L-glu were similar and characterized by increases in minute ventilation, tidal volume, inspiratory drive, respiratory frequency, mean arterial blood pressure (MAP) and heart rate (HR). In the regions located between the areas described above two different breathing patterns were obtained without significant changes in MAP or HR. These patterns were characterized by decreases and increases in the respiratory indices analyzed, with the exception of respiratory frequency, which decreased in both regions. These results suggest that within the VMS discrete areas may act as functional units modulating cardiorespiratory responses while in others these functions are spatially segregated.
authors.affiliation: Departamento de Fisiologia, Universidade Federal de São Paulo, Escola Paulista de Medicina, SP, Brasil.
authors.forename: F P
authors.initials: FP
authors.lastname: Tolentino-Silva
authors.forename: R R
authors.initials: RR
authors.lastname: Campos Júnior
authors.forename: A K
authors.initials: AK
authors.lastname: Russo
authors.forename: S L
authors.initials: SL
authors.lastname: Cravo
authors.forename: O U
authors.initials: OU
authors.lastname: Lopes
mesh_terms: D000818:Animals; D002320:Cardiovascular Physiological Phenomena; D002319:Cardiovascular System / Q000187:drug effects*; D018698:Glutamic Acid / Q000494:pharmacology*; D008297:Male; D008526:Medulla Oblongata / Q000033:anatomy & histology / Q000187:drug effects* / Q000502:physiology; D008845:Microinjections; D051381:Rats; D017208:Rats, Wistar; D012119:Respiration / Q000187:drug effects* / Q000502:physiology; D012143:Respiratory Physiological Phenomena; D012137:Respiratory System / Q000187:drug effects
chemical_list: D018698:Glutamic Acid