Frequency of HLA-B27 subtypes in a Danish population and in Danish patients with ankylosing spondylitis.
Polymerase chain reaction in combination with sequence-specific oligonucleotide probes were used to analyze nine HLA-B27 subtypes among 51 healthy HLA-B27 positive Danish blood donors and 30 Danish HLA-B27 positive patients with ankylosing spondylitis (AS). In the group of healthy Danes we found two subtypes, B*2705 (90.2%) and B*2702 (9.8%), however, among the AS patients only the B*2705 subtype was detected. We did not find a significant evidence for associations between AS and a particular HLA-B27 subtype in a Danish population.
Baech
J
J
Regional Centre for Blood Transfusion and Clinical Immunology, Aalborg Hospital, Denmark.
Schmidt-Olsen
S
S
Steffensen
R
R
Varming
K
K
Grunnet
N
N
Jersild
C
C
D003718:Denmark; D005787:Gene Frequency; D015796:HLA-B27 Antigen / Q000235:genetics*; D006801:Humans; D013167:Spondylitis, Ankylosing / Q000453:epidemiology / Q000235:genetics* / Q000276:immunology
D015796:HLA-B27 Antigen