title: Daily fluctuation of levels of circulating cathodic antigen in urine of children infected with Schistosoma mansoni in Brazil.
abstract: The fluctuation of circulating cathodic antigen (CCA) levels in urine was studied in 69 Brazilian school-children infected with Schistosoma mansoni and compared to egg counts. Faeces and urine samples were simultaneously collected at 7 times during a period of 2 weeks. CCA was determined by enzyme-linked immunosorbent assay and could be detected in 96% of the urine samples; the individual mean CCA level ranged from 609 to 350,700 pg/mL. 90% of the faecal samples contained S. mansoni eggs and the individual mean egg output ranged from 9 to 5510 eggs/g. The Spearman rank correlation coefficient between these individual means was 0.69. Kendall's coefficient of concordance (W) was 0.88 for CCA levels and 0.80 for egg counts.
authors.affiliation: Laboratory of Parasitology, Medical Faculty, University of Leiden, The Netherlands.
authors.forename: J
authors.initials: J
authors.lastname: Disch
authors.forename: M M
authors.initials: MM
authors.lastname: Garcia
authors.forename: G W
authors.initials: GW
authors.lastname: Krijger
authors.forename: M N
authors.initials: MN
authors.lastname: Amorim
authors.forename: N
authors.initials: N
authors.lastname: Katz
authors.forename: A M
authors.initials: AM
authors.lastname: Deelder
authors.forename: B
authors.initials: B
authors.lastname: Gryseels
authors.forename: A
authors.initials: A
authors.lastname: Rabello
mesh_terms: D000293:Adolescent; D000818:Animals; D000947:Antigens, Helminth / Q000652:urine*; D001938:Brazil; D002648:Child; D004797:Enzyme-Linked Immunosorbent Assay; D005188:False Negative Reactions; D005243:Feces / Q000469:parasitology; D005260:Female; D006801:Humans; D008297:Male; D010270:Parasite Egg Count; D015203:Reproducibility of Results; D012550:Schistosoma mansoni / Q000276:immunology*; D012555:Schistosomiasis mansoni / Q000276:immunology / Q000469:parasitology / Q000652:urine*
chemical_list: D000947:Antigens, Helminth