title: Dynamic intravenous coronary arteriography using synchrotron radiation and its application to the measurement of coronary blood flow.
abstract: We have developed dynamic intravenous coronary arteriography (IVCAG) using a monochromatic (33.3 keV), 2-dimensional X-ray beam (70 x 70 mm) generated from synchrotron radiation. To investigate its use to visualize the coronary arteries and to estimate coronary blood flow, we performed IVCAG in 10 dogs and 1 goat. The animals were irradiated with the synchrotron beam after intravenous injection of a contrast agent, and images were obtained using a TV camera and videorecorder. In the dogs, blood flow in the left anterior descending coronary artery (LAD) was also estimated from the images by applying a transit-time analysis. We obtained dynamic IVCAG images in the dogs and goat and could visualize even a deliberately created coronary stenosis about 1 mm in length. In addition, coronary blood flow could be estimated with an acceptable degree of accuracy. LAD flow calculated from IVCAG was 14.7 +/- 5.1 ml/min, whereas measured LAD flow was 16.6 +/- 4.8 ml/min. There was a close correlation between the estimated and measured LAD flows (r = 0.90, p < 0.01). Thus, dynamic IVCAG is minimally invasive, permits the simultaneous evaluation of coronary anatomy and blood flow, and may be feasible for clinical application.
authors.affiliation: Department of Cardiology, University of Tsukuba, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Ohtsuka
authors.forename: Y
authors.initials: Y
authors.lastname: Sugishita
authors.forename: T
authors.initials: T
authors.lastname: Takeda
authors.forename: Y
authors.initials: Y
authors.lastname: Itai
authors.forename: K
authors.initials: K
authors.lastname: Hyodo
authors.forename: M
authors.initials: M
authors.lastname: Ando
mesh_terms: D000818:Animals; D001783:Blood Flow Velocity; D017023:Coronary Angiography / Q000379:methods*; D003326:Coronary Circulation / Q000502:physiology*; D003327:Coronary Disease / Q000000981:diagnostic imaging; D004285:Dogs; D005260:Female; D006041:Goats; D017356:Synchrotrons