title: Absence of neuroanatomical and behavioral deficits in L7/pcp-2-null mice.
abstract: L7/pcp-2 is expressed exclusively in cerebellar Purkinje and retinal bipolar neurons. While the function of L7/pcp-2 is unknown, its mRNA is trafficked into dendrites, suggesting a role in dendritic physiology. To elucidate its function, L7/pcp-2-null mice were generated. These mice are neurologically normal with no signs of cerebellar or retinal dysfunction. The mice are indistinguishable from wild-type littermates with regards to gross neuroanatomy and fine structure of Purkinje cell dendrites.
authors.affiliation: Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
authors.forename: G
authors.initials: G
authors.lastname: Vassileva
authors.forename: R J
authors.initials: RJ
authors.lastname: Smeyne
authors.forename: J I
authors.initials: JI
authors.lastname: Morgan
mesh_terms: D000818:Animals; D020662:Guanine Nucleotide Exchange Factors; D051379:Mice; D008810:Mice, Inbred C57BL; D009479:Neuropeptides / Q000502:physiology*; D011689:Purkinje Cells / Q000502:physiology*; D012160:Retina / Q000502:physiology*
chemical_list: D020662:Guanine Nucleotide Exchange Factors; D009479:Neuropeptides; C104971:Pcp2 protein, mouse