[Cholesterol and development].
The teratogenic action of distal inhibitors of cholesterol synthesis has been known for some time. The induced malformations are of a particular type: they include holoprosencephalies. Recently these observations have solicited increased interest due to: 1/ the discovery in 1993 of a similar form of inhibition of cholesterol synthesis which is responsible for a human malformation syndrome, Smith-Lemli-Opitz; 2/ the demonstration of the involvement of the Sonic Hedgehog gene in normal development of prosencephalon and the description of the mode of action of the protein Shh: autoprocessing followed by "cholesterolisation".
Roux
C
C
Laboratoire d'Embryologie pathologique expérimentale, CHU Saint-Antoine, Paris.
Wolf
C
C
Llirbat
B
B
Kolf
M
M
Mulliez
N
N
Taillemite
J L
JL
Cormier
V
V
Le Merrer
M
M
Chevy
F
F
Citadelle
D
D
D000818:Animals; D000924:Anticholesteremic Agents / Q000494:pharmacology; D002784:Cholesterol / Q000097:blood / Q000235:genetics / Q000494:pharmacology*; D005314:Embryonic and Fetal Development / Q000187:drug effects* / Q000235:genetics; D005796:Genes; D016142:Holoprosencephaly / Q000139:chemically induced / Q000209:etiology / Q000235:genetics; D066298:In Vitro Techniques; D051379:Mice; D051381:Rats; D001371:trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride / Q000494:pharmacology
D000924:Anticholesteremic Agents; D001371:trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride; D002784:Cholesterol