Molecular mechanisms in the antiproliferative action of quercetin.
A single treatment with quercetin (5.5 microM), a plant flavonoid, activated both apoptosis and differentiation programs in K562 human leukemia cells. K562 cells expressed commitment to apoptosis after 1 h exposure, however, at least 12 h of drug exposure was needed to induce differentiation. Early (1 h) down-regulation of the c-myc and Ki-ras oncogenes and rapid reduction of inositol-1,4,5-trisphosphate (IP3) concentration (IC50 = 9 microM, 1 h incubation) are part of the antiproliferative action of quercetin and appear to relate to induction of differentiation and/or apoptotic program of K562 leukemia cells treated with quercetin.
Csokay
B
B
National Institute of Oncology, Dept. Molecular Biology, Budapest, Hungary.
Prajda
N
N
Weber
G
G
Olah
E
E
D017209:Apoptosis / Q000187:drug effects; D002454:Cell Differentiation / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects*; D015536:Down-Regulation / Q000187:drug effects; D004920:Erythropoiesis / Q000187:drug effects; D016259:Genes, myc / Q000235:genetics; D011905:Genes, ras / Q000235:genetics; D006427:Hemin / Q000494:pharmacology; D006801:Humans; D015544:Inositol 1,4,5-Trisphosphate / Q000378:metabolism; D011794:Quercetin / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
D006427:Hemin; D015544:Inositol 1,4,5-Trisphosphate; D011794:Quercetin