Primary choroidal melanoma in a patient with previous cutaneous melanoma.
A 67-year-old woman with a history of a skin melanoma that was excised 7 years previously had a 6-month history of decreased vision in her right eye. A choroidal melanoma was diagnosed clinically, and the eye was enucleated. The results of a histopathological examination revealed a primary uveal melanoma. Slides of the skin melanoma were obtained, and the initial diagnosis was confirmed. In an attempt to illustrate a biological difference between the 2 melanomas, immunohistochemical studies were performed on sections of the 2 specimens using S-100 protein, HMB-45, and S-100-beta. Primary cutaneous and choroidal melanomas appearing in a patient with no predisposition are rare; this is believed to be only the fifth such case reported in the literature.
Scull
J J
JJ
Department of Opthalmology, Royal Victoria Hospital, McGill University Faculty of Medicine, Montreal, Quebec.
Alcocer
C E
CE
Deschènes
J
J
Burnier
M N
MN
D000368:Aged; D005260:Female; D006801:Humans; D008545:Melanoma / Q000473:pathology*; D016609:Neoplasms, Second Primary; D012878:Skin Neoplasms / Q000473:pathology*; D014604:Uveal Neoplasms / Q000473:pathology*