[In situ thrombolysis. Correlation between creatine phosphokinase increase and local thrombolysis. An experimental study in the rat].
This study proposes intraarterial in situ thrombolysis for the treatment of microthrombi occurring after tissue crushing. In order to assess the efficacy of the thrombolytic, the authors assayed the serum creatine phosphokinase (CPK) level in the crushed muscle capillary bed. The action of thrombolytics has now been clearly established. In contrast, the correlation between local thrombolysis and the serum CPK variation in crush injuries of striated muscle constitutes the originality of this paper. This experiment was conducted in twenty Wistar rats in which striated muscle crushing was performed. The serum CPK level assayed in venous blood, obtained from the capillary bed concerned, before and after local thrombolysis. The increased CPK level provided an objective indication of the efficacy of intra-arterial thrombolysis after crush injury. The authors now apply local thrombolysis according to a prospective clinical protocol for hand emergencies associated with a crush mechanism.
Knipper
P
P
Service de Chirurgie Orthopédique et Réparatrice, Hôpital Boucicaut, Paris, France.
Maladry
D
D
Mitz
V
V
D000818:Animals; D003402:Creatine Kinase / Q000097:blood*; D007269:Injections, Intra-Arterial; D008297:Male; D008866:Microsurgery; D018482:Muscle, Skeletal / Q000293:injuries*; D010960:Plasminogen Activators / Q000008:administration & dosage; D051381:Rats; D017208:Rats, Wistar; D012106:Research; D015912:Thrombolytic Therapy / Q000379:methods*; D014568:Urokinase-Type Plasminogen Activator / Q000008:administration & dosage
D003402:Creatine Kinase; D010960:Plasminogen Activators; D014568:Urokinase-Type Plasminogen Activator