title: [Laryngeal cancer and conservative treatment. Place of combined radiotherapy chemotherapy and modified fractionation radiotherapy].
abstract: For patients with early stages of laryngeal carcinomas, the local therapeutic modalities of surgery and/or radiation are the accepted standards of treatment. Recently, combined chemotherapy-radiotherapy and new fractionation schedules have received much attention as an alternative to surgery in patients with resectable locally advanced cancer of the larynx to preserve the larynx function. This article is intended to update the reader on the most recent articles written about the treatment of laryngeal carcinomas. The different points are: the results of conventional radiotherapy, the importance of parameters of radiotherapy (dose, fractionation, overall treatment time), new fractionation schedules, combined chemo-radiotherapy, randomized trial results.
authors.affiliation: Départment de radiothérapie oncologique. Institut Curie, Paris, France.
authors.forename: F
authors.initials: F
authors.lastname: Brunin
authors.forename: J
authors.initials: J
authors.lastname: Rodriguez
authors.forename: C
authors.initials: C
authors.lastname: Jaulerry
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D019583:Dose Fractionation, Radiation; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D007822:Laryngeal Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy / Q000628:therapy*; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D010699:Phonation; D011379:Prognosis; D011878:Radiotherapy / Q000379:methods*; D011879:Radiotherapy Dosage; D016019:Survival Analysis; D016896:Treatment Outcome