title: [The effect of perftoran on the resistance of mice to GABA receptor antagonists and on the antidote activity of anticonvulsant agents].
abstract: Perfluorane (a phenobarbital-type inducer of the microsomal enzyme system) raised the resistance of mice to the toxic effect of picrotoxin and bicucullin in 7 days after injection. The antidote effect of diazepam and phenobarbital increased under such conditions. In experiments in vitro a modulatory effect of perftorane on the central muscarine and benzodiazepine receptors was demonstrated.
authors.forename: A I
authors.initials: AI
authors.lastname: Golovko
authors.forename: T V
authors.initials: TV
authors.lastname: Kliuntina
authors.forename: M B
authors.initials: MB
authors.lastname: Ivanov
authors.forename: G A
authors.initials: GA
authors.lastname: Sofronov
authors.forename: O A
authors.initials: OA
authors.lastname: Sviderskiĭ
authors.forename: V V
authors.initials: VV
authors.lastname: Shilov
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use*; D000931:Antidotes / Q000627:therapeutic use*; D001640:Bicuculline / Q000506:poisoning; D003975:Diazepam / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical; D004351:Drug Resistance; D004357:Drug Synergism; D005466:Fluorocarbons / Q000494:pharmacology / Q000627:therapeutic use*; D018756:GABA Antagonists / Q000506:poisoning*; D008297:Male; D051379:Mice; D010634:Phenobarbital / Q000627:therapeutic use; D010852:Picrotoxin / Q000506:poisoning; D011041:Poisoning / Q000188:drug therapy; D011963:Receptors, GABA-A / Q000187:drug effects; D011976:Receptors, Muscarinic / Q000187:drug effects
chemical_list: D000927:Anticonvulsants; D000931:Antidotes; D001640:Bicuculline; D003975:Diazepam; D005466:Fluorocarbons; D018756:GABA Antagonists; D010634:Phenobarbital; D010852:Picrotoxin; D011963:Receptors, GABA-A; D011976:Receptors, Muscarinic; C063334:perftoran