Antecedents of cerebral palsy in a multicenter trial of indomethacin for intraventricular hemorrhage.
OBJECTIVE
To determine if cerebral palsy (CP) rates were lower in the active treatment group compared with the control group, as improved survival rates of very low-birth-weight infants are postulated to be the cause of the increased incidence of CP in preterm infants, to evaluate relationships between multiple prenatal, perinatal, and postnatal variables and CP to understand better its antecedents in very low-birth-weight infants in the era of surfactant replacement therapy, and to determine the usefulness of a cranial ultrasonographic (US) scan in predicting CP.


METHODS
Inception cohort follow-up study as part of a randomized controlled trial of low-dose indomethacin sodium for the prevention of intraventricular hemorrhage.


METHODS
Neonatal intensive care units at 3 medical centers.


METHODS
Infants with birth weights between 600 and 1250 g were eligible, and 505 infants were enrolled in the original study. Of these infants, 440 (87%) survived; neurologic examinations were completed on 381 infants (86%) at 36 months corrected age.


METHODS
Statistical analyses were performed to identify the antecedents of CP, including the results of frequent cranial US scans obtained throughout the newborn period.


RESULTS
Cerebral palsy was found in 36 (9.5%) of 381 infants at 36 months corrected age (range, 33-39 months corrected age). Univariate analysis identified chorioamnionitis, treatment with surfactant, bronchopulmonary dysplasia, and abnormal cranial US findings as antecedents of CP. Periventricular leukomalacia and ventriculomegaly were associated with the highest detection rates for CP (37% and 30%, respectively) with acceptable false-positive rates. Multivariate analysis identified bronchopulmonary dysplasia and an abnormal cranial US scan showing grade 3 to 4 intraventricular hemorrhage, periventricular leukomalacia, or ventriculomegaly as independent predictors of CP. Odds ratios for the detection of CP using cranial US findings tabulated by hospital day were in the range of 7 to 26 beginning on day 2.


CONCLUSIONS
The results suggest that cranial US findings are useful predictors of CP during a patient's stay in the hospital.
Allan
W C
WC
Division of Pediatric Neurology, Maine Medical Center, Portland, USA.
Vohr
B
B
Makuch
R W
RW
Katz
K H
KH
Ment
L R
LR
D002543:Cerebral Hemorrhage / Q000188:drug therapy*; D002547:Cerebral Palsy / Q000150:complications / Q000175:diagnosis* / Q000517:prevention & control; D002552:Cerebral Ventricles; D002821:Chorioamnionitis / Q000150:complications; D005260:Female; D005865:Gestational Age; D006801:Humans; D007213:Indomethacin / Q000627:therapeutic use*; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D019102:Infant, Very Low Birth Weight; D007969:Leukomalacia, Periventricular / Q000150:complications; D011247:Pregnancy; D012189:Retrospective Studies; D013501:Surface-Active Agents / Q000627:therapeutic use
D013501:Surface-Active Agents; D007213:Indomethacin