title: Comparison of human and murine isolates of Schistosoma mansoni from Richard-Toll, Senegal, by isoelectric focusing.
abstract: Studies on human and murine isolates of Schistosoma mansoni, from Richard-Toll, Senegal, were carried out by isoelectric focusing in polyacrylamide gels. Seven enzyme systems; lactate dehydrogenase (LDH), malate dehydrogenase (MDH), glucose-6-phosphate dehydrogenase (G6PD), acid phosphatase (AcP), hexokinase (HK), glucose phosphate isomerase (GPI), and phosphoglucomutase (PGM), were used to compare the two isolates. All systems tested, apart from LDH, were found to be polymorphic for both isolates. Interestingly, one phenotype is more frequent than the remainder. The results show that there is no significant genetic variation between the S. mansoni isolates from man and the rodents, Arvicanthis niloticus and Mastomys huberti.
authors.affiliation: Programme 'Eau et Santé', ORSTOM, Dakar, Sénégal.
authors.forename: M
authors.initials: M
authors.lastname: Sène
authors.forename: P
authors.initials: P
authors.lastname: Brémond
authors.forename: J P
authors.initials: JP
authors.lastname: Hervé
authors.forename: V R
authors.initials: VR
authors.lastname: Southgate
authors.forename: B
authors.initials: B
authors.lastname: Sellin
authors.forename: B
authors.initials: B
authors.lastname: Marchand
authors.forename: J M
authors.initials: JM
authors.lastname: Duplantier
mesh_terms: D000135:Acid Phosphatase / Q000737:chemistry; D000820:Animal Diseases / Q000469:parasitology; D000818:Animals; D014644:Genetic Variation; D005956:Glucose-6-Phosphate Isomerase / Q000737:chemistry; D005954:Glucosephosphate Dehydrogenase / Q000737:chemistry; D006593:Hexokinase / Q000737:chemistry; D006801:Humans; D007525:Isoelectric Focusing; D007770:L-Lactate Dehydrogenase / Q000737:chemistry; D008291:Malate Dehydrogenase / Q000737:chemistry; D010641:Phenotype; D010733:Phosphoglucomutase / Q000737:chemistry; D051381:Rats; D012550:Schistosoma mansoni / Q000201:enzymology / Q000235:genetics*; D012555:Schistosomiasis mansoni / Q000469:parasitology; D012675:Senegal
chemical_list: D007770:L-Lactate Dehydrogenase; D008291:Malate Dehydrogenase; D005954:Glucosephosphate Dehydrogenase; D006593:Hexokinase; D000135:Acid Phosphatase; D005956:Glucose-6-Phosphate Isomerase; D010733:Phosphoglucomutase