title: Local capture by atrial pacing in spontaneous chronic atrial fibrillation.
abstract: BACKGROUND
  Atrial fibrillation (AF) is considered to be maintained by multiple reentrant circuits without or with a very short excitable gap. However, the possibility of local atrial capture has been shown recently in experimental AF or induced AF in humans.
  
  
  RESULTS
  This study was undertaken to evaluate the feasibility of atrial capture-suggestive of an excitable gap-in spontaneous chronic AF. Decremental pacing was performed in 47 right atrial sites in 14 patients with chronic AF, not taking antiarrhythmic drugs. A Franz catheter (for pacing and monophasic action potential recording) and a recording quadripolar catheter positioned about 10 mm apart were used. Local capture was achieved in 41 (87.2%) sites for a total of 100 captures. In 71 episodes the capture was lost within 15 seconds, while in the remaining 29, pacing was stopped after 15 seconds of stable capture. AF types immediately before capture were type 1 in 83 and type 2 in 17 episodes. Type 3 AF was never captured. Pacing cycle at capture was 175.7 +/- 20.9 ms. The baseline atrial interval (FF) was 185.4 +/- 24.5, significantly longer than the FF recorded during pacing immediately before capture (176.0 +/- 19.8 ms) (P < .02).
  
  
  CONCLUSIONS
  During spontaneous chronic AF in humans, (1) local capture by atrial pacing is possible up to at least 15 mm from the pacing site, (2) regional entrainment is possible during type 1 and type 2 AF but not type 3 AF, and (3) pacing before capture accelerates AF, probably by transient or local capture. These findings suggest that an excitable gap is present in chronic AF, therefore supporting the hypothesis that leading circle reentry is not the unique electrophysiological mechanism maintaining the arrhythmia.
authors.affiliation: Department of Cardiac Diseases, San Filippo Neri Hospital, Rome, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Pandozi
authors.forename: L
authors.initials: L
authors.lastname: Bianconi
authors.forename: M
authors.initials: M
authors.lastname: Villani
authors.forename: A
authors.initials: A
authors.lastname: Castro
authors.forename: G
authors.initials: G
authors.lastname: Altamura
authors.forename: S
authors.initials: S
authors.lastname: Toscano
authors.forename: A P
authors.initials: AP
authors.lastname: Jesi
authors.forename: G
authors.initials: G
authors.lastname: Gentilucci
authors.forename: F
authors.initials: F
authors.lastname: Ammirati
authors.forename: F
authors.initials: F
authors.lastname: Lo Bianco
authors.forename: M
authors.initials: M
authors.lastname: Santini
mesh_terms: D000368:Aged; D001281:Atrial Fibrillation / Q000145:classification / Q000503:physiopathology / Q000628:therapy*; D016275:Atrial Function; D002304:Cardiac Pacing, Artificial; D002908:Chronic Disease; D004594:Electrophysiology; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged