title: Identification of the novel antimicrobial fatty acid (5Z,9Z)-14-methyl-5,9-pentadecadienoic acid in Eunicea succinea.
abstract: The phospholipid fatty acid composition of Eunicea succinea was investigated, and the novel (5Z,9Z)-14-methyl-5,9-pentadecadienoic acid was identified. Structural characterization was accomplished by means of mass spectrometry of its pyrrolidide derivative, NMR, FT1R, and total synthesis. Other interesting phospholipid fatty acids in E. succinea were the tetracosapolyenoic acids 6,9,12,15,18,21-tetracosahexaenoic acid (24:6) and 6,9,12,15,18-tetracosapentaenoic acids (24:5). The title compound was particularly active against Gram-positive bacteria such as Staphylococcus aureus (MIC 0.24 mumol/mL) and Streptococcus faecalis (MIC 0.16 mumol/ mL).
authors.affiliation: Department of Chemistry, University of Puerto Rico, San Juan, Puerto Rico 00931. ncarball@upracd.upr.clu.edu
authors.forename: N M
authors.initials: NM
authors.lastname: Carballeira
authors.forename: E D
authors.initials: ED
authors.lastname: Reyes
authors.forename: A
authors.initials: A
authors.lastname: Sostre
authors.forename: A D
authors.initials: AD
authors.lastname: Rodríguez
authors.forename: J L
authors.initials: JL
authors.lastname: Rodríguez
authors.forename: F A
authors.initials: FA
authors.lastname: González
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000302:isolation & purification* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D003063:Cnidaria / Q000378:metabolism*; D005231:Fatty Acids, Unsaturated / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: C106394:14-methyl-5,9-pentadecadienoic acid; D000900:Anti-Bacterial Agents; D005231:Fatty Acids, Unsaturated