Inclusion of trithia[5]heterohelicene by various serum albumins. An effective probe for chiral discrimination.
Racemic 2-hydroxymethyltrithia[5]heterohelicene (2-HT), which has a labile helical structure was incorporated into serum albumins of nine species in 1% ethanolic aqueous solution, giving 1:1 complexes which exhibited induced circular dichroism spectra with species specificity. The application of 2-HT to bovine serum as a probe for chiral recognition revealed that the serum itself manifested an apparent chiral discrimination between enantiomers of 2-HT.
Yamada
K
K
Faculty of Pharmaceutical Sciences, Josai University, Saitama, Japan.
Ishii
R
R
Nakagawa
H
H
Kawazura
H
H
D000818:Animals; D002417:Cattle; D002645:Chickens; D002942:Circular Dichroism; D006041:Goats; D006168:Guinea Pigs; D006736:Horses; D006801:Humans; D007202:Indicators and Reagents; D011817:Rabbits; D051381:Rats; D012709:Serum Albumin / Q000737:chemistry*; D013045:Species Specificity; D013056:Spectrophotometry, Ultraviolet; D013552:Swine; D013876:Thiophenes / Q000737:chemistry*
D007202:Indicators and Reagents; D012709:Serum Albumin; D013876:Thiophenes