[Comparative study of three antineoplastic alkylating agents on DNA].
The influence of three alkylating anticancer preparations phosphamide, sarcolysine, cyclophosphane on content of the 5-methylcytosine and parameters of the melting DNA of the liver healthy animals and tumor sarcoma 45 was investigated. It was shown, that among the investigated preparations cyclophosphane has stronger anticancer influence and comparatively weaker side effect on DNA liver. We came to the conclusion that it is preferable to use this preparation.
Babaian
Iu S
IuS
Khudaverdian
N V
NV
Karapetian
L G
LG
Kazarian
R S
RS
Sogomonian
L R
LR
D000818:Animals; D018906:Antineoplastic Agents, Alkylating / Q000494:pharmacology*; D003520:Cyclophosphamide / Q000494:pharmacology; D004247:DNA / Q000187:drug effects*; D004273:DNA, Neoplasm / Q000494:pharmacology*; D004117:Dimethoate / Q000494:pharmacology; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008558:Melphalan / Q000494:pharmacology; D012513:Sarcoma, Experimental / Q000235:genetics / Q000473:pathology
D018906:Antineoplastic Agents, Alkylating; D004273:DNA, Neoplasm; D003520:Cyclophosphamide; D004247:DNA; D008558:Melphalan; D004117:Dimethoate