title: Combined hepatocellular carcinoma and cholangiocarcinoma in a mare.
abstract: A hepatic malignant tumour composed of both hepatocellular and cholangiocellular elements was studied histologically, immunohistochemically and electron microscopically in an 18-year-old Thoroughbred mare. Bile canaliculi and alpha-fetoprotein were useful in identifying the hepatocellular element, and mucin and keratin were good markers of biliary differentiation. The simultaneous presence of bile canaliculi and mucin-producing cells in most of the neoplastic lesions suggested that this tumour arose from a stem cell with capacity to differentiate into hepatocytes and biliary epithelium.
authors.affiliation: Ishikari Livestock Hygiene Service Centre, Sapporo, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Kato
authors.forename: T
authors.initials: T
authors.lastname: Higuchi
authors.forename: Y
authors.initials: Y
authors.lastname: Orita
authors.forename: Y
authors.initials: Y
authors.lastname: Ishikawa
authors.forename: K
authors.initials: K
authors.lastname: Kadota
mesh_terms: D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000473:pathology / Q000662:veterinary*; D018281:Cholangiocarcinoma / Q000473:pathology / Q000662:veterinary*; D005260:Female; D006734:Horse Diseases / Q000473:pathology*; D006736:Horses; D008113:Liver Neoplasms / Q000473:pathology* / Q000662:veterinary*; D009378:Neoplasms, Multiple Primary / Q000473:pathology* / Q000662:veterinary*