title: An evaluation of tumour vascularity as a prognostic indicator in uveal melanoma.
abstract: Experimental and clinical evidence suggests that tumour angiogenesis plays a role in the tendency for certain neoplasms, including cutaneous melanomas, to metastasize. We evaluated whether tumour vasculature is associated with the rate of metastases in patients with melanoma of the choroid or ciliary body. The study was based on a group of 63 patients enucleated between 1976 and 1984 with paraffin-embedded tissue blocks available for sectioning and with known survival status as of December 1988. Vessel endothelial cells were highlighted with Ulex europaeus agglutinin I (UEA-I) conjugated with peroxidase. UEA-I-stained microvessels were counted at varying levels in the tumour (apex, centre and base) without knowledge of patient outcome. Patients with (n = 30) and without (n = 33) metastases had similar total vessel counts (P = 0.31). There was no evidence of greater vessel density in tumours that had metastasized, by level within the tumour. Similar results were obtained in multivariate analyses. Findings of this study suggest that tumour microvessel density is unrelated to patient survival in uveal melanoma.
authors.affiliation: Retina Service, Massachusetts Eye and Ear Infirmary, Boston 02114, USA.
authors.forename: A M
authors.initials: AM
authors.lastname: Lane
authors.forename: K M
authors.initials: KM
authors.lastname: Egan
authors.forename: J
authors.initials: J
authors.lastname: Yang
authors.forename: M A
authors.initials: MA
authors.lastname: Saornil
authors.forename: J
authors.initials: J
authors.lastname: Alroy
authors.forename: D
authors.initials: D
authors.lastname: Albert
authors.forename: E S
authors.initials: ES
authors.lastname: Gragoudas
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D037102:Lectins; D008297:Male; D008545:Melanoma / Q000098:blood supply* / Q000473:pathology; D008833:Microcirculation / Q000737:chemistry / Q000473:pathology; D008875:Middle Aged; D009389:Neovascularization, Pathologic / Q000473:pathology*; D037121:Plant Lectins; D011379:Prognosis; D015996:Survival Rate; D014604:Uveal Neoplasms / Q000098:blood supply* / Q000473:pathology
chemical_list: D037102:Lectins; D037121:Plant Lectins; C036850:Ulex europaeus lectins