The effect of long-term oestradiol implantation on bone mineral density in postmenopausal women who have undergone hysterectomy and bilateral oophorectomy.
Twelve women who had received oestradiol implantation on demand for at least 15 years following hysterectomy with bilateral oophorectomy, underwent bone densitometry of hip and spine. Bone mass of hip and spine was significantly elevated above that of both the age matched mean to a degree hitherto undocumented. This suggests that oestrogen in high doses or over a long period may produce a true anabolic effect on bone mass.
Wahab
M
M
Department of Obstetrics and Gynaecology, Princess Royal Hospital, Hull, UK.
Ballard
P
P
Purdie
D W
DW
Cooper
A
A
Willson
J C
JC
D015502:Absorptiometry, Photon; D000368:Aged; D015519:Bone Density / Q000187:drug effects*; D004343:Drug Implants; D004958:Estradiol / Q000494:pharmacology*; D015914:Estrogen Replacement Therapy; D005260:Female; D005272:Femur Neck / Q000000981:diagnostic imaging; D006801:Humans; D007044:Hysterectomy; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging; D008875:Middle Aged; D010052:Ovariectomy; D010865:Pilot Projects; D017698:Postmenopause / Q000187:drug effects*; D011877:Radionuclide Imaging; D013997:Time Factors
D004343:Drug Implants; D004958:Estradiol