title: Low-grade central osteosarcoma resembling fibrous dysplasia. A report of two cases.
abstract: We describe 2 cases of low-grade central osteosarcoma mimicking fibrous dysplasia and present a review of the literature. These cases illustrate the importance of obtaining a large representative sample of tumor in suspicious lesions, because it may be difficult or impossible to histologically distinguish low-grade central osteosarcoma from a benign lesion with limited samples from a core biopsy or needle aspiration. The treatment of choice for low-grade central osteosarcoma is resection with wide surgical margins or, if limb salvage is not technically feasible, amputation.
authors.affiliation: Department of Orthopedics, Botsford General Hospital, Farmington Hills, Michigan, USA.
authors.forename: M J
authors.initials: MJ
authors.lastname: Franceschina
authors.forename: R C
authors.initials: RC
authors.lastname: Hankin
authors.forename: R B
authors.initials: RB
authors.lastname: Irwin
mesh_terms: D000293:Adolescent; D003937:Diagnosis, Differential; D005260:Female; D005266:Femoral Neoplasms / Q000473:pathology* / Q000601:surgery; D005357:Fibrous Dysplasia of Bone / Q000473:pathology*; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D012516:Osteosarcoma / Q000473:pathology* / Q000601:surgery