Involvement of a peripheral mechanism in the emesis induced by cardiac glycosides in Suncus murinus.
The ability of three cardiac glycosides, ouabain, digitonin and digitoxin, to induce emesis and their mechanism(s) of action were investigated in Suncus murinus. The intraperitoneal injection of ouabain but not digitonin nor digitoxin caused vomiting in a dose-dependent manner. However, the administration of ouabain into the cerebroventricle did not cause emesis. Ouabain-induced emesis was partly prevented by surgical abdominal vagotomy. Pretreatment with tropisetron, a selective 5-HT3 (5-hydroxytriptamine) receptor antagonist, did not affect the emetic response evoked by ouabain. These results suggest that ouabain exerts emetic effects via peripheral mechanism(s), but 5-HT3 receptors are not involved in the pathway.
Kakimoto
S
S
Department of Chemical Pharmacology, Faculty of Pharmaceutical Science, The University of Tokyo, Bunkyo-ku, Japan.
Saito
H
H
Matsuki
N
N
D000818:Animals; D000932:Antiemetics / Q000494:pharmacology; D002301:Cardiac Glycosides / Q000008:administration & dosage / Q000633:toxicity*; D004072:Digitonin / Q000008:administration & dosage / Q000633:toxicity; D004074:Digitoxin / Q000008:administration & dosage / Q000633:toxicity; D005260:Female; D007211:Indoles / Q000494:pharmacology; D007274:Injections, Intraperitoneal; D007276:Injections, Intraventricular; D008297:Male; D010042:Ouabain / Q000008:administration & dosage / Q000633:toxicity; D011985:Receptors, Serotonin / Q000378:metabolism; D044406:Receptors, Serotonin, 5-HT3; D012702:Serotonin Antagonists / Q000494:pharmacology; D012788:Shrews; D000077526:Tropisetron; D014628:Vagotomy; D014839:Vomiting / Q000139:chemically induced / Q000503:physiopathology* / Q000517:prevention & control
D000932:Antiemetics; D002301:Cardiac Glycosides; D007211:Indoles; D011985:Receptors, Serotonin; D044406:Receptors, Serotonin, 5-HT3; D012702:Serotonin Antagonists; D010042:Ouabain; D000077526:Tropisetron; D004074:Digitoxin; D004072:Digitonin