title: Cortical and hippocampal volume deficits in temporal lobe epilepsy.
abstract: OBJECTIVE
  To use quantitative magnetic resonance imaging (MRI) methods to examine the extent of volume abnormalities in the hippocampus and in extrahippocampal brain regions in localization-related epilepsy of temporal lobe origin (TLE).
  
  
  METHODS
  Hippocampal, temporal lobe, and extratemporal lobe volumes were examined with 3-mm spin-echo coronal MRI scans in patients with unilateral TLE who were candidates for temporal lobe resection. Measures were adjusted for normal variation due to intracranial volume and age based on 72 healthy male controls. Group differences between 14 male TLE [7 left TLE (LTLE), 7 right TLE (RTLE)] patients and a subset of 49 age range-matched controls were examined with analysis of variance (ANOVA).
  
  
  RESULTS
  As compared with controls, patients with TLE had smaller temporal lobe and frontoparietal region gray matter volumes, bilaterally, smaller temporal lobe white matter volumes bilaterally, and larger ventricular volumes. In contrast to these bilateral tissue volume deficits, hippocampal volume deficits in TLE were ipsilateral to the epileptogenic temporal lobe.
  
  
  CONCLUSIONS
  Extrahippocampal volume abnormalities were bilateral and occurred in both temporal and extra-temporal cortical regions in TLE, whereas hippocampal deficits were related to the side of the epileptogenic focus. These data suggest that brain abnormalities in TLE are not limited to the epileptogenic region.
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, California 94305-5546, USA.
authors.forename: L
authors.initials: L
authors.lastname: Marsh
authors.forename: M J
authors.initials: MJ
authors.lastname: Morrell
authors.forename: P K
authors.initials: PK
authors.lastname: Shear
authors.forename: E V
authors.initials: EV
authors.lastname: Sullivan
authors.forename: H
authors.initials: H
authors.lastname: Freeman
authors.forename: A
authors.initials: A
authors.lastname: Marie
authors.forename: K O
authors.initials: KO
authors.lastname: Lim
authors.forename: A
authors.initials: A
authors.lastname: Pfefferbaum
mesh_terms: D000293:Adolescent; D000328:Adult; D001921:Brain / Q000033:anatomy & histology* / Q000473:pathology; D002552:Cerebral Ventricles / Q000033:anatomy & histology / Q000473:pathology; D004833:Epilepsy, Temporal Lobe / Q000175:diagnosis* / Q000473:pathology; D005625:Frontal Lobe / Q000033:anatomy & histology / Q000473:pathology; D007839:Functional Laterality; D006624:Hippocampus / Q000033:anatomy & histology* / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010296:Parietal Lobe / Q000033:anatomy & histology / Q000473:pathology; D013702:Temporal Lobe / Q000033:anatomy & histology* / Q000473:pathology