Treatment of capillary vascular malformation (port-wine stains) with photochemotherapy.
One-hundred and thirty patients (85 female, 45 male) with port-wine stains were treated with photodynamic therapy, also called photochemotherapy, which recently has become acknowledged as effective for a variety of malignant tumors. Probably based on the photochemical reaction with the generation of toxic species, photochemotherapy results in endothelial cell injury and death of abnormal capillaries under overlying epidermis. A retrospective review of 118 available patients with port-wine stains reveals that 98.3 percent responded to photochemotherapy with varying degrees of success after one-time treatment. Results were reported under a simple classification system ranging from ordinary to dilated to posttreatment type. In the ordinary group, the results evaluated as excellent, good, fair, and poor were 37.8, 53.7, 8.5, and 0 percent, respectively, before a second treatment; the treated area was an average of 9.8 (range 7 to 13) cm in diameter. In addition, hypertrophic scars, permanent hyperpigmentation, and hypopigmentation were not seen based on proper parameters. Photochemotherapy offers a potentially efficient and promising choice based on a completely different mechanism from that of selected photothermal therapy with the pulsed-dye laser.
Lin
X X
XX
Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, China.
Wang
W
W
Wu
S F
SF
Yang
C
C
Chang
T S
TS
D000293:Adolescent; D000328:Adult; D000368:Aged; D002196:Capillaries / Q000187:drug effects; D002648:Child; D002675:Child, Preschool; D017439:Cicatrix, Hypertrophic / Q000517:prevention & control; D004730:Endothelium, Vascular / Q000187:drug effects; D005260:Female; D006415:Hematoporphyrins / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D017495:Hyperpigmentation / Q000517:prevention & control; D017496:Hypopigmentation / Q000517:prevention & control; D007275:Injections, Intravenous; D017075:Laser Coagulation; D053685:Laser Therapy; D008297:Male; D008875:Middle Aged; D010778:Photochemotherapy; D019339:Port-Wine Stain / Q000188:drug therapy* / Q000473:pathology; D011838:Radiation-Sensitizing Agents / Q000008:administration & dosage / Q000627:therapeutic use; D012074:Remission Induction; D019233:Retreatment; D012189:Retrospective Studies; D012867:Skin / Q000098:blood supply
D006415:Hematoporphyrins; D011838:Radiation-Sensitizing Agents; C052552:photocarcinorin