title: Molecular genetic events in the development and progression of ovarian cancer in humans.
abstract: Ovarian tumor development is characterized by specific clinical and pathological features that provide an interesting model of carcinogenesis: first, the pre-invasive and even invasive lesions are difficult to detect; second, a group of cases with a known familial predilection constitute an important heredltary model of carcinogenesis; and third, the category of morphologically borderline ovarian tumors (tumors of low malignant potential) poses several unanswered questions such as: what histologic criteria should be used for their diagnosis; what is their natural history; and what is their molecular relationship to invasive tumors? Recently, molecular studies have contributed to a better understanding of the biology of these tumors, their behavior in vivo, and their response to therapy. This article summarizes the most recent molecular advances.
authors.affiliation: Laboratory of Pathology, National Cancer Institute, Bethesda, MD 20892, USA.
authors.forename: R F
authors.initials: RF
authors.lastname: Chuaqui
authors.forename: Z
authors.initials: Z
authors.lastname: Zhuang
authors.forename: M J
authors.initials: MJ
authors.lastname: Merino
mesh_terms: D001943:Breast Neoplasms / Q000235:genetics; D002872:Chromosome Deletion; D002874:Chromosome Mapping; D004198:Disease Susceptibility; D005190:Family; D005260:Female; D016147:Genes, Tumor Suppressor; D008040:Genetic Linkage; D006133:Growth Substances / Q000502:physiology; D006801:Humans; D010051:Ovarian Neoplasms / Q000235:genetics* / Q000473:pathology / Q000503:physiopathology*; D011956:Receptors, Cell Surface / Q000502:physiology; D017978:Receptors, Growth Factor / Q000502:physiology
chemical_list: D006133:Growth Substances; D011956:Receptors, Cell Surface; D017978:Receptors, Growth Factor