title: Treatment outcome and prognostic factors for primary mediastinal (thymic) B-cell lymphoma: a multicenter study of 106 patients.
abstract: OBJECTIVE
  To define clinicopathologic features, response to treatment, and prognostic factors of primary mediastinal B-cell lymphoma (MBL), a CD20+ tumor recognized as a distinct entity among non-Hodgkin's lymphomas (NHL).
  
  
  METHODS
  One hundred six patients presented with disease confined to thorax (86%), bulky mediastinum (73%), superior vena cava syndrome (47%), and contiguous infiltration (57%). Ninety-nine received doxorubicin-containing chemotherapy (CHT).
  
  
  RESULTS
  Thirty-five of 99 patients were primarily CHT-resistant, and 64 responded: 23 achieved complete response (CR) and 41 achieved response with residual mediastinal abnormality. Seventy-seven percent of responders received mediastinal radiotherapy (RT). Of 64 responders, 18 (28%) relapsed: none of 23 CR patients and 18 of 41 (44%) with residual mediastinal abnormality. Relapse-free survival rate of responders was 71% at 3 years. Actuarial 3-year survival rate was 52% for all patients and 82% for responders. Predictive factors of poor outcome were identified by logistic regression; Cox survival analysis was performed on death and relapse. Pericardial effusion (P < .001) and Eastern Cooperative Oncology Group (ECOG) performance status > or = 2 (P = .009) predicted nonresponse (NR) and affected survival. Less than partial midway response to CHT predicted NR to subsequent therapies. Bulky disease was related to persistent mediastinal abnormality and risk of relapse (P = .025).
  
  
  CONCLUSIONS
  MBL is an aggressive NHL with unique clinicopathologic aspects, often refractory to current CHT designed for high-grade NHL. Poor performance status and pericardial effusion predict NR and poor survival. Inadequate response after the first courses of front-line CHT predicts failure of subsequent treatment. Responders with bulky mediastinum or residual mediastinal abnormality after CHT are at risk of relapse. These factors should help to select high-risk patients for intensive treatments.
authors.affiliation: Department of Pathology, University of Pavia, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Lazzarino
authors.forename: E
authors.initials: E
authors.lastname: Orlandi
authors.forename: M
authors.initials: M
authors.lastname: Paulli
authors.forename: J
authors.initials: J
authors.lastname: Sträter
authors.forename: C
authors.initials: C
authors.lastname: Klersy
authors.forename: U
authors.initials: U
authors.lastname: Gianelli
authors.forename: L
authors.initials: L
authors.lastname: Gargantini
authors.forename: M T
authors.initials: MT
authors.lastname: Rousset
authors.forename: M
authors.initials: M
authors.lastname: Gambacorta
authors.forename: E
authors.initials: E
authors.lastname: Marra
authors.forename: T
authors.initials: T
authors.lastname: Lavabre-Bertrand
authors.forename: U
authors.initials: U
authors.lastname: Magrini
authors.forename: C
authors.initials: C
authors.lastname: Manegold
authors.forename: C
authors.initials: C
authors.lastname: Bernasconi
authors.forename: P
authors.initials: P
authors.lastname: Möller
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D018572:Disease-Free Survival; D004317:Doxorubicin / Q000008:administration & dosage; D005060:Europe; D005260:Female; D006801:Humans; D016393:Lymphoma, B-Cell / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D018714:Radiotherapy, Adjuvant; D012189:Retrospective Studies; D012307:Risk Factors; D016019:Survival Analysis; D013953:Thymus Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy / Q000628:therapy*; D016896:Treatment Outcome
chemical_list: D004317:Doxorubicin