title: [The clinical significance of the liver glutathione system in chronic lesions].
abstract: It is shown that chronic hepatobiliary pathology is associated with a fall in spontaneous metabolite conjugation related to reduced concentration of hepatic glutathione. There was also enhanced activity of glutathione-dependent enzymes. This indicates progress of compensatory processes associated with mobilization of detoxication phase 2, i.e. stimulation of conjugation processes under depression of cytochrome P-450 system. The authors ascertain high informative value of hepatic glutathione transferase in assessment of disease activity in patients with chronic active hepatitis and hepatic cirrhosis.
authors.forename: A S
authors.initials: AS
authors.lastname: Loginov
authors.forename: B N
authors.initials: BN
authors.lastname: Matiushin
authors.forename: V D
authors.initials: VD
authors.lastname: Tkachev
mesh_terms: D001707:Biopsy, Needle; D002908:Chronic Disease; D004796:Clinical Enzyme Tests; D005978:Glutathione / Q000032:analysis / Q000378:metabolism*; D005979:Glutathione Peroxidase / Q000032:analysis; D005980:Glutathione Reductase / Q000032:analysis; D005982:Glutathione Transferase / Q000032:analysis; D006801:Humans; D008099:Liver / Q000737:chemistry / Q000201:enzymology* / Q000473:pathology; D008107:Liver Diseases / Q000175:diagnosis*; D010084:Oxidation-Reduction
chemical_list: D005979:Glutathione Peroxidase; D005980:Glutathione Reductase; D005982:Glutathione Transferase; D005978:Glutathione