title: MEG-based imaging of focal neuronal current sources.
abstract: We describe a new approach to imaging neural current sources from measurements of the magnetoencephalogram (MEG) associated with sensory, motor, or cognitive brain activation. Many previous approaches to this problem have concentrated on the use of weighted minimum norm (WMN) inverse methods. While these methods ensure a unique solution, they do not introduce information specific to the MEG inverse problem, often producing overly smoothed solutions and exhibiting severe sensitivity to noise. We describe a Bayesian formulation of the inverse problem in which a Gibbs prior is constructed to reflect the sparse focal nature of neural current sources associated with evoked response data. We demonstrate the method with simulated and experimental phantom data, comparing its performance with several WMN methods.
authors.affiliation: Signal and Image Processing Institute, University of Southern California, Los Angeles 90089, USA. jamesphi@sipi.usc.edu
authors.forename: J W
authors.initials: JW
authors.lastname: Phillips
authors.forename: R M
authors.initials: RM
authors.lastname: Leahy
authors.forename: J C
authors.initials: JC
authors.lastname: Mosher
mesh_terms: D001499:Bayes Theorem; D001921:Brain / Q000502:physiology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D015225:Magnetoencephalography; D019047:Phantoms, Imaging