Distribution study of radioactivity in rats after oral administration of the lipido/sterolic extract of Serenoa repens (Permixon) supplemented with [1-14C]-lauric acid, [1-14C]-oleic acid or [4-14C]-beta-sitosterol.
The study carried out on rats given orally the n-hexane lipido/sterolic extract of Serenoa repens (LSESR), supplemented with [14C]-labelled oleic or lauric acids or beta-sitosterol, demonstrated that radioactivity uptake in prostatic tissues shows the highest level in the case of administration of LSESR supplemented with [14C]-labelled oleic acid. This was clearly demonstrated on a rat with an induced fibro-muscular hyperplasia of the prostate and by quantitative measurements of radioactivity. Ratios of radioactivity in tissues compared to plasma show an uptake of radioactivity greater in prostate as compared to other genital organs, i.e. the seminal vesicles or to other organs such as liver.
Chevalier
G
G
Ecole Nationale Vétérinaire, Département des Sciences Biologiques et Fonctionnelles, Toulouse, France.
Benard
P
P
Cousse
H
H
Bengone
T
T
D000284:Administration, Oral; D000726:Androgen Antagonists / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D000818:Animals; D001345:Autoradiography; D002250:Carbon Radioisotopes; D007850:Lauric Acids / Q000378:metabolism*; D008297:Male; D019301:Oleic Acid / Q000378:metabolism*; D010936:Plant Extracts / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D051381:Rats; D011919:Rats, Inbred Strains; D028024:Serenoa; D012855:Sitosterols / Q000378:metabolism*; D014018:Tissue Distribution
D000726:Androgen Antagonists; D002250:Carbon Radioisotopes; D007850:Lauric Acids; D010936:Plant Extracts; D012855:Sitosterols; C030358:lauric acid; D019301:Oleic Acid; C025473:gamma-sitosterol; C040972:saw palmetto extract