Two patients with recurrent melioidosis after prolonged antibiotic therapy.
Melioidosis is a tropical infectious disease caused by Burkholderia (Pseudomonas) pseudomalleï. Clinically manifest melioidosis occurs mostly in people with underlying disorders. Melioidosis is a disease with protein manifestations and a high rate of relapse. Two patients with infection due to Burkholderia pseudomalleï after a visit to Thailand are described. Both patients presented with sepsis and appropriate therapy was initiated and continued for several months. Despite such long-term antimicrobial treatment, both patients had a relapse after cessation of therapy. It is unclear if recurrent melioidosis can be prevented by prolonging the treatment even further.
Silbermann
M H
MH
Department of Hematology, University Hospital Rotterdam, The Netherlands.
Gyssens
I C
IC
Endtz
H P
HP
Kuijper
E J
EJ
van der Meer
J T
JT
D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D016957:Burkholderia pseudomallei; D004359:Drug Therapy, Combination; D006801:Humans; D008297:Male; D008554:Melioidosis / Q000188:drug therapy* / Q000382:microbiology; D008875:Middle Aged; D012008:Recurrence; D013785:Thailand
D000900:Anti-Bacterial Agents