Pterulinic acid and pterulone, two novel inhibitors of NADH:ubiquinone oxidoreductase (complex I) produced by a Pterula species. I. Production, isolation and biological activities.
Pterulinic acid (1) and pterulone (2), two novel halogenated antibiotics, were isolated from fermentations of Pterula sp. 82168. Both compounds exhibited significant antifungal and weak or no cytotoxic activities. 1 and 2 are effective inhibitors of eucaryotic respiration. The target of the antibiotics resides within the mitochondrial NADH:ubiquinone oxidoreductase (complex I).
Engler
M
M
LB Biotechnologie der Universität, Kaiserslautern, FRG.
Anke
T
T
Sterner
O
O
Brandt
U
U
D000085:Acetates / Q000302:isolation & purification* / Q000494:pharmacology*; D000818:Animals; D000935:Antifungal Agents / Q000302:isolation & purification* / Q000494:pharmacology*; D001572:Benzofurans / Q000302:isolation & purification* / Q000494:pharmacology*; D002417:Cattle; D002851:Chromatography, High Pressure Liquid; D042967:Electron Transport Complex I; D005285:Fermentation; D008826:Microbial Sensitivity Tests; D008928:Mitochondria / Q000187:drug effects; D009247:NADH, NADPH Oxidoreductases / Q000037:antagonists & inhibitors*; D010082:Oxepins; D010101:Oxygen Consumption; D013237:Stereoisomerism; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000085:Acetates; D000935:Antifungal Agents; D001572:Benzofurans; D010082:Oxepins; C106751:pterulinic acid; C106752:pterulone; D009247:NADH, NADPH Oxidoreductases; D042967:Electron Transport Complex I