Electrocochleographic analysis of the suppression of tinnitus by electrical promontory stimulation.
To investigate the origin, and evaluate the mechanism by which tinnitus is suppressed we performed electrical promontory stimulation (EPS) in 56 patients with tinnitus, and measured the compound action potential (CAP) using electrocochleography before and after EPS. In the group of patients in whom tinnitus was suppressed, the CAP amplitudes increased significantly, whereas the latencies showed no remarkable change. In the group of patients in whom tinnitus was not suppressed, both the CAP amplitudes and latencies exhibited no significant change. These data indicate that the effect on the cochlear nerve plays an important role in the suppression of tinnitus by EPS. The CAP reflects the number of the auditory nerve fibers which discharge synchronously. It is speculated that an increase of the CAP amplitudes is caused by synchronizing discharges of the auditory nerve fibers, and that the mechanism by which EPS suppresses tinnitus may be related to synchronizing these discharges.
Watanabe
K
K
Department of Otolaryngology, Nippon Medical School, Tokyo, Japan.
Okawara
D
D
Baba
S
S
Yagi
T
T
D000328:Adult; D000368:Aged; D001300:Audiometry, Evoked Response; D001309:Auditory Threshold / Q000502:physiology; D004599:Electric Stimulation Therapy / Q000295:instrumentation*; D004566:Electrodes; D005260:Female; D006801:Humans; D008144:Loudness Perception / Q000502:physiology; D008297:Male; D008875:Middle Aged; D010898:Pitch Perception / Q000502:physiology; D012815:Signal Processing, Computer-Assisted; D014012:Tinnitus / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*; D016896:Treatment Outcome