title: Transcription regulation and alternative splicing of an early zygotic gene encoding two structurally distinct zinc finger proteins in Xenopus laevis.
abstract: We describe the structural organization of a gene, termed XFDL 141/156, that is transiently activated during early Xenopus development. XFDL 141/156 is first transcribed at the midblastula transition (MBT) and during early gastrulation events. A roughly 200 nucleotide fragment immediately 5' to the transcription start site is sufficient for transient, early zygotic activation of gene expression. The primary transcript is subject to alternative splicing. Corresponding cDNAs encode two structurally related but completely distinct C2H2-type zinc finger proteins of unknown biological function.
authors.affiliation: Institut für Biochemie und Molekulare Zellbiologie, Göttingen, Germany.
authors.forename: E
authors.initials: E
authors.lastname: Bellefroid
authors.forename: C
authors.initials: C
authors.lastname: Bourguignon
authors.forename: T
authors.initials: T
authors.lastname: Bouwmeester
authors.forename: O
authors.initials: O
authors.lastname: Rausch
authors.forename: B
authors.initials: B
authors.lastname: Blumberg
authors.forename: T
authors.initials: T
authors.lastname: Pieler
mesh_terms: D017398:Alternative Splicing; D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D001755:Blastocyst / Q000502:physiology; D002352:Carrier Proteins / Q000096:biosynthesis* / Q000737:chemistry; D018076:DNA, Complementary; D004625:Embryo, Nonmammalian / Q000502:physiology; D005775:Gastrula / Q000502:physiology; D018507:Gene Expression Regulation, Developmental; D008969:Molecular Sequence Data; D011993:Recombinant Fusion Proteins / Q000096:biosynthesis; D012045:Regulatory Sequences, Nucleic Acid; D015183:Restriction Mapping; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D014158:Transcription, Genetic; D029867:Xenopus Proteins; D014982:Xenopus laevis / Q000196:embryology* / Q000235:genetics; D016335:Zinc Fingers; D015053:Zygote / Q000502:physiology*
chemical_list: D002352:Carrier Proteins; D018076:DNA, Complementary; D011993:Recombinant Fusion Proteins; C106865:XFDL protein, Xenopus; D029867:Xenopus Proteins