Is MK-801 neuroprotection mediated by systemic hypothermia in the immature rat?
Hypothermia after hypoxia-ischaemia (HI) confounds the interpretation of the effects of neuroprotective drug intervention. The effect of 0.5 mg/kg of dizocilpine (MK-801) administered after HI on rectal temperature at 2-36 h and on brain damage 2 weeks after the insult was evaluated in the immature rat. In pups kept at an ambient temperature of 21 degrees C, MK-801 lowered the temperature by 1.1 degrees C and reduced the brain damage by 45%. In pups held at an ambient temperature of 33 degrees C, MK-801 treatment afforded a 34% reduction of brain damage without lowering the rectal temperature. In conclusion, the neuroprotection offered by MK-801 does not depend on systemic hypothermia in this model.
Gilland
E
E
Department of Obstetrics and Gynecology, Göteborg University, Sweden.
Hagberg
H
H
D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D001831:Body Temperature / Q000187:drug effects*; D002545:Brain Ischemia / Q000503:physiopathology*; D016291:Dizocilpine Maleate / Q000494:pharmacology*; D005260:Female; D007035:Hypothermia / Q000503:physiopathology*; D002534:Hypoxia, Brain / Q000503:physiopathology*; D008297:Male; D018696:Neuroprotective Agents / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012007:Rectum
D018696:Neuroprotective Agents; D016291:Dizocilpine Maleate