The number of triplet repeats in five brain-expressed loci with CAG repeats is not associated with schizophrenia.
We have previously shown that large expansions of CAG (CTG) triplets are associated both with schizophrenia itself and with an early age-at-onset of the disease. However, the repeat expansion detection (RED) method used did not provide a chromosomal location for the expanded region(s) (Morris et al., 1995). In a further study of our schizophrenic and control patients, we have now examined the length of the repeated sequence in five loci that are expressed in brain and are known to contain CAG repeat regions (Li et al., 1993). No enlarged repeat regions were identified; it is unlikely therefore that expansions at any of these five loci can account for expansions of up to 136 triplets identified by the RED method.
Gaitonde
E J
EJ
Department of Experimental Psychology, University of Cambridge, UK.
Sivagnanasundaram
S
S
Morris
A G
AG
McKenna
P J
PJ
Mollon
J D
JD
Hunt
D M
DM
D017668:Age of Onset; D000483:Alleles; D001483:Base Sequence; D001921:Brain / Q000473:pathology*; D002869:Chromosome Aberrations; D025063:Chromosome Disorders; D002882:Chromosomes, Human, Pair 13; D002893:Chromosomes, Human, Pair 3; D017931:DNA Primers; D005260:Female; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D011110:Polymorphism, Genetic; D012559:Schizophrenia / Q000235:genetics* / Q000473:pathology*; D018911:Trinucleotide Repeats
D017931:DNA Primers