High sialic acid reactivity of sugar chain structure Lewis-X in patients with mental retardation.
It has been reported that platelet-derived growth factor B-chains homodimer (PDGF-BB) improves learning function of mice, and that sugar chain structure Lewis-X of N-glycosylated glycoprotein promotes PDGF-BB secretion from platelets. Based on these findings, we assumed that learning dysfunction in some patients with mental retardation might be due to abnormality in PDGF-BB metabolism and/or Lewis-X structure. No difference in the reactivity of PDGF-BB and Lewis-X was found between the serum of patients with mental retardation and that of normals. But sialic acid reactivity of the Lewis-X fraction in some patients was remarkably higher than that in other patients and in normals. These findings suggest that sialic acids in the Lewis-X fraction may have a relation to one of the causes of learning dysfunction in these patients.
Masuda
Y
Y
Department of Neuropsychiatry, Akita University School of Medicine, Japan.
Ohnuma
S
S
Shimizu
T
T
Hishikawa
Y
Y
D000328:Adult; D000818:Animals; D000077214:Becaplermin; D001921:Brain / Q000378:metabolism; D004314:Down Syndrome / Q000097:blood* / Q000523:psychology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005732:Gangliosides / Q000097:blood*; D006801:Humans; D008607:Intellectual Disability / Q000097:blood* / Q000209:etiology / Q000523:psychology; D007360:Intelligence / Q000502:physiology; D016256:Lewis X Antigen / Q000097:blood*; D008297:Male; D051379:Mice; D010982:Platelet-Derived Growth Factor / Q000378:metabolism*; D020574:Proto-Oncogene Proteins c-sis; D012016:Reference Values; D000080506:Sialyl Lewis X Antigen
D005732:Gangliosides; D016256:Lewis X Antigen; D010982:Platelet-Derived Growth Factor; D020574:Proto-Oncogene Proteins c-sis; D000080506:Sialyl Lewis X Antigen; C094688:sialyl Lewis(x) ganglioside; D000077214:Becaplermin