Reflux oesophagitis and clozapine.
In a series of thirty-six patients treated with clozapine we report four cases who developed upper gastrointestinal symptoms suggestive of reflux oesophagitis within 6 weeks of starting this drug. Subsequent endoscopic examination revealed moderately severe erosive oesophagitis in three of them. Of these one had received treatment for a peptic ulcer in the past but the other two had no previous history of any upper gastrointestinal disorder. The pharmacology of clozapine in relation to gastro-oesophageal reflux is discussed.
Laker
M K
MK
Academic Unit of Human Psychopharmacology, Royal London and St Bartholomew's Hospital (NHS) Trust, St Clement's Hospital, UK.
Cookson
J C
JC
D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D003024:Clozapine / Q000009:adverse effects* / Q000627:therapeutic use; D004942:Esophagitis, Peptic / Q000139:chemically induced* / Q000473:pathology; D004945:Esophagoscopy; D006801:Humans; D008297:Male; D008875:Middle Aged; D012559:Schizophrenia / Q000150:complications / Q000188:drug therapy
D014150:Antipsychotic Agents; D003024:Clozapine