title: Effect of tissue factor deficiency on mouse and tumor development.
abstract: Previous reports suggest that tissue factor (TF) may play an essential role in embryonic vascular development and tumor angiogenesis. To further examine this relationship, the morphology of fully developed TF-deficient embryos and the growth of TF-deficient teratomas and teratocarcinomas were analyzed. In a 129/Sv genetic background, TF null embryos do not survive beyond mid-gestation. In contrast, 14% of 129/Sv x C57BL/6 TF-deficient embryos escape this early mortality and survive to birth. On gross and microscopic inspection, these late gestation, TF-deficient embryos appear normal. The growth and vascularity of TF(+/+), TF(+/-), and TF(-/-) teratomas and teratocarcinomas are indistinguishable. Thus, tumor-derived TF is not required for tumor growth and angiogenesis and the combined data do not support an essential role for TF in embryonic vascular development.
authors.affiliation: Division of Hematology, Washington University School of Medicine, Barnes-Jewish Hospital, St. Louis, MO 63110, USA.
authors.forename: J R
authors.initials: JR
authors.lastname: Toomey
authors.forename: K E
authors.initials: KE
authors.lastname: Kratzer
authors.forename: N M
authors.initials: NM
authors.lastname: Lasky
authors.forename: G J
authors.initials: GJ
authors.lastname: Broze
mesh_terms: D000818:Animals; D005314:Embryonic and Fetal Development / Q000235:genetics*; D005260:Female; D017353:Gene Deletion; D018507:Gene Expression Regulation, Developmental; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D011247:Pregnancy; D018243:Teratocarcinoma / Q000235:genetics / Q000473:pathology*; D013724:Teratoma / Q000235:genetics / Q000473:pathology*; D013736:Testicular Neoplasms / Q000235:genetics / Q000473:pathology*; D013925:Thromboplastin / Q000172:deficiency / Q000235:genetics*
chemical_list: D013925:Thromboplastin