Intracellular free magnesium concentrations in skeletal muscle in chronic uraemia.
Low intracellular free magnesium concentrations ([Mg2+]i) are associated with essential hypertension and may reflect a disordered cellular ionic environment. 31P magnetic resonance spectroscopy was used to study skeletal muscle [Mg2+]i in a group of chronic renal failure (CRF) patients and data were compared with a group of control subjects of similar age. Other data including the patients' blood pressure, medication and plasma biochemistry were collected. There was a significant inverse correlation of [Mg2+]i with systolic (p < 0.001) and diastolic blood pressure (p < 0.05) in the CRF population. In CRF [Mg2+]i was similar (0.52 +/- 0.01 mM, SEM) to controls (0.53 +/- 0.01 mM; p = 0.20), even if just the normotensive patients and controls were compared. There was no correlation of [Mg2+]i with plasma parathyroid hormone, total [Mg2+] or [Ca2+]. Similar to studies in subjects with essential hypertension, these data support a role for [Mg2+]i specifically, and an abnormal intracellular environment more generally, in the pathophysiology of hypertension in CRF.
Irish
A B
AB
Department of Nephrology, Churchill Hospital, Oxford, UK.
Thompson
C H
CH
Kemp
G J
GJ
Taylor
D J
DJ
Radda
G K
GK
D000328:Adult; D000368:Aged; D000959:Antihypertensive Agents / Q000008:administration & dosage; D001786:Blood Glucose; D001794:Blood Pressure; D002121:Calcium Channel Blockers / Q000008:administration & dosage; D002908:Chronic Disease; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000378:metabolism; D008274:Magnesium / Q000032:analysis* / Q000097:blood; D008297:Male; D016555:Matched-Pair Analysis; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000737:chemistry* / Q000378:metabolism; D009543:Nifedipine / Q000008:administration & dosage; D010531:Peritoneal Dialysis, Continuous Ambulatory; D006435:Renal Dialysis; D014511:Uremia / Q000378:metabolism*
D000959:Antihypertensive Agents; D001786:Blood Glucose; D002121:Calcium Channel Blockers; D008274:Magnesium; D009543:Nifedipine