Nontoxic embolic liquids for treatment of arteriovenous malformations.
Interventional radiology is becoming one of the standard treatments of arteriovenous malformation (AVM). Cyanoacrylate derivatives and polymer solutions are widely used to occlude the AVM nidus by their injection through a catheter, but they are far from satisfactory embolic liquids. For instance, cyanoacrylate derivatives sometimes glue the catheter to the artery, resulting in serious complications; in addition, the organic solvents used to dissolve polymers cause damage to the surrounding brain tissue of the AVM. Therefore, we attempted to develop embolic liquids by dissolving poly(2-hydroxyethyl methacrylate-co-methyl methacrylate) in Iopamiron with an addition of a small amount of ethyl alcohol. This new embolic liquid is not cytotoxic and is easily injected into the AVM through a thin, long catheter to effectively occlude the AVM.
Kazekawa
K
K
Department of Neurosurgery, Fukuoka Tokushukai Medical Center, Japan.
Iwata
H
H
Shimozuru
T
T
Sampei
K
K
Sakaki
N
N
Morikawa
N
N
Matsuda
S
S
Ikada
Y
Y
D000818:Animals; D001165:Arteriovenous Malformations / Q000628:therapy*; D001672:Biocompatible Materials / Q000633:toxicity; D001921:Brain / Q000473:pathology; D002460:Cell Line; D003487:Cyanoacrylates; D004621:Embolization, Therapeutic; D006801:Humans; D002538:Intracranial Arteriovenous Malformations / Q000000981:diagnostic imaging / Q000628:therapy*; D008768:Methylmethacrylates / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D051379:Mice; D011102:Polyhydroxyethyl Methacrylate / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D011817:Rabbits; D011859:Radiography
D001672:Biocompatible Materials; D003487:Cyanoacrylates; D008768:Methylmethacrylates; D011102:Polyhydroxyethyl Methacrylate; C040206:HTR composite