Clinical evaluation of indomethacin-containing patches for osteoarthritis and extremity trauma.
Seventy-eight patients, aged 12-87 years, with osteoarthritis or extremity trauma, attached one indomethacin patch (containing 96 mg indomethacin) to the most symptomatic site twice daily. The final overall treatment outcome was excellent in 52% of the osteoarthritic patients and in 82% of the trauma patients, good in 27% and 13%, and fair in 3% and 0%, respectively. Side effects were reported by 4% of the patients. It is concluded that indomethacin-containing patches were effective and well-tolerated for the treatment of osteoarthritis and extremity trauma.
Hatori
M
M
Department of Orthopaedic Surgery, Tohoku University School of Medicine, Sendai, Japan.
Kokubun
S
S
D000279:Administration, Cutaneous; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage* / Q000009:adverse effects; D002648:Child; D005121:Extremities / Q000293:injuries*; D006801:Humans; D007213:Indomethacin / Q000008:administration & dosage* / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D010003:Osteoarthritis / Q000188:drug therapy*; D013180:Sprains and Strains / Q000188:drug therapy; D016896:Treatment Outcome; D014947:Wounds and Injuries / Q000188:drug therapy*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007213:Indomethacin