title: Biological reaction to debris in relation to joint prostheses.
abstract: Bone loss induced by the inflammatory response to wear particles is a major cause of long-term failure of total joint replacement. This review describes the cellular reaction occurring in response to these particles and what is currently known about the inflammatory mechanisms contributing to bone resorption.
authors.affiliation: Department of Histopathology, Royal Free Hospital, School of Medicine.
authors.forename: P A
authors.initials: PA
authors.lastname: Revell
authors.forename: N
authors.initials: N
authors.lastname: al-Saffar
authors.forename: A
authors.initials: A
authors.lastname: Kobayashi
mesh_terms: D001843:Bone Cements; D001862:Bone Resorption; D001842:Bone and Bones / Q000166:cytology; D016207:Cytokines / Q000032:analysis; D005549:Foreign-Body Reaction / Q000209:etiology / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D007249:Inflammation; D007595:Joint Prosthesis; D010010:Osteoclasts / Q000166:cytology; D011475:Prosthesis Failure; D012106:Research
chemical_list: D001843:Bone Cements; D016207:Cytokines