title: Role of supplementation of a nucleic acid solution on the intestinal mucosa under total parenteral nutrition.
abstract: Since dietary nucleotides play an important role in the growth and development of the intestine, supplementation of a nucleic acid solution (OG-VI) may support the optimal growth and integrity of the intestine under total parenteral nutrition (TPN). Supplementation of OG-VI to a TPN solution improved mucosal morphologic and functional changes, increased mucosal proliferation, and decreased mucosal permeability of the intestine. After 80% small bowel resection, OG-VI supplementation to a TPN solution attenuated the initial mucosal atrophy and improved intestinal cell turnover. Nucleic acid supplementation may be clinically beneficial in certain situations.
authors.affiliation: Department of Surgery, Toyonaka Municipal Hospital, Osaka, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Tsujinaka
authors.forename: M
authors.initials: M
authors.lastname: Kishibuchi
authors.forename: S
authors.initials: S
authors.lastname: Iijima
authors.forename: M
authors.initials: M
authors.lastname: Yano
authors.forename: M
authors.initials: M
authors.lastname: Monden
mesh_terms: D000818:Animals; D002455:Cell Division; D006801:Humans; D007413:Intestinal Mucosa / Q000166:cytology / Q000502:physiology*; D009696:Nucleic Acids / Q000008:administration & dosage*; D009705:Nucleosides / Q000008:administration & dosage*; D009711:Nucleotides / Q000008:administration & dosage*; D010289:Parenteral Nutrition, Total; D011687:Purines / Q000378:metabolism; D012996:Solutions
chemical_list: D009696:Nucleic Acids; D009705:Nucleosides; D009711:Nucleotides; C087081:OG-VI solution; D011687:Purines; D012996:Solutions