title: Systemic ehrlichiosis presenting as progressive hepatosplenomegaly.
abstract: A 42-year-old white man had headache, fever, chills, abdominal pain, nausea and vomiting, night sweats, and dark urine for 3 days before admission; he had history of a tick bite 6 weeks earlier. Progressive systemic deterioration, heralded by progressive hepatosplenomegaly and pancytopenia, occurred despite doxycycline therapy. Subsequent recovery was preceded by progressive resolution of hepatosplenomegaly. Progressive hepatosplenomegaly has not been previously reported in association with systemic monocytic ehrlichiosis.
authors.affiliation: Department of Internal Medicine, John L. McClellan Memorial Veterans Hospital, Little Rock, USA.
authors.forename: A D
authors.initials: AD
authors.lastname: Friedman
authors.forename: G K
authors.initials: GK
authors.lastname: Daniel
authors.forename: W A
authors.initials: WA
authors.lastname: Qureshi
mesh_terms: D000328:Adult; D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001733:Bites and Stings; D004318:Doxycycline / Q000627:therapeutic use; D016873:Ehrlichiosis / Q000175:diagnosis* / Q000503:physiopathology; D005334:Fever / Q000503:physiopathology; D006261:Headache / Q000503:physiopathology; D006529:Hepatomegaly / Q000382:microbiology*; D006801:Humans; D008297:Male; D009325:Nausea / Q000503:physiopathology; D010198:Pancytopenia / Q000503:physiopathology; D012768:Shivering / Q000502:physiology; D013163:Splenomegaly / Q000382:microbiology*; D013546:Sweating; D013987:Ticks; D014839:Vomiting / Q000503:physiopathology
chemical_list: D000900:Anti-Bacterial Agents; D004318:Doxycycline