title: Large B-cell lymphoma of the uterine corpus: case report with immunohistochemical and molecular study.
abstract: Primary lymphoma of the uterine corpus (PLUC) is an extremely rare neoplasm. We report a case of PLUC in a 78-year-old woman with vaginal bleeding without hepatosplenomegaly, adenopathies, or bone marrow infiltration, classified as stage I. A diagnosis of diffuse large B-cell lymphoma was made in endometrial curettage tissue. Immunohistochemical study showed tumoral cells of B-cell nature. Two different polymerase chain reaction (PCR) techniques showed immunoglobulin heavy chain gene rearrangement and we could not demonstrate, with PCR technique, either Epstein-Barr virus or papilloma virus infection. Total hysterectomy with bilateral salpingo-oophorectomy was carried out and adjuvant chemotherapy was given. She was alive and free of disease after a follow-up period of 7 years, and the patient has been in perfect health.
authors.affiliation: Department of Pathology, Hospital Juan Canalejo, La Coruña, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Alvarez
authors.forename: J A
authors.initials: JA
authors.lastname: Ortiz
authors.forename: F
authors.initials: F
authors.lastname: Sacristán
mesh_terms: D000368:Aged; D004273:DNA, Neoplasm / Q000032:analysis; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D016393:Lymphoma, B-Cell / Q000473:pathology*; D014594:Uterine Neoplasms / Q000473:pathology*
chemical_list: D004273:DNA, Neoplasm