Depletion of tumor necrosis factor-alpha in mice by Nyctanthes arbor-tristis.
The effect of the water soluble fraction of the ethanol extract of Nyctanthes arbor-tristis (NAT) on tumor necrosis factor-alpha (TNF-alpha) level in plasma of arthritic and soluble protein A (SpA)-treated Balb/c mice has been studied. Oral administration of this fraction in arthritic mice showed a consistent depletion of TNF-alpha from the host plasma. A similar depletion of TNF-alpha in the plasma of SpA-treated mice has been observed. The extract also reduces plasma interferon-gamma level but the plasma IgM and IgG levels are not affected. The implications of these observations are discussed in the light of management of TNF-alpha in clinical disorders.
Paul
B N
BN
Immunobiology Laboratory, Industrial Taxicology Research Centre, Lucknow, India.
Saxena
A K
AK
D000284:Administration, Oral; D000818:Animals; D001169:Arthritis, Experimental / Q000097:blood / Q000188:drug therapy; D001798:Blood Proteins / Q000378:metabolism; D004195:Disease Models, Animal; D004591:Electrophoresis, Polyacrylamide Gel; D000431:Ethanol / Q000737:chemistry; D015151:Immunoblotting; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D007371:Interferon-gamma / Q000097:blood; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D010946:Plants, Medicinal / Q000378:metabolism; D013205:Staphylococcal Protein A / Q000633:toxicity; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
D001798:Blood Proteins; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D010936:Plant Extracts; D013205:Staphylococcal Protein A; D014409:Tumor Necrosis Factor-alpha; D000431:Ethanol; D007371:Interferon-gamma