title: A rational approach to treating hypercholesterolaemia in children. Weighing the risks and benefits.
abstract: Because atherosclerosis is a continuous process throughout life, expert panels have suggested guidelines to reduce the risk of cardiovascular disease, starting from childhood. The guidelines focus on population-based measures and on treating hypercholesterolaemia in individual children. Low-fat diets in children have been widely debated. There is little evidence that growth is stunted or that nutritional deficiencies arise if the energy that is lost by limiting fat intake is substituted with other nutrients. Dietary fibre, plant sterols and fish oils have been used to modify lipid levels in children; however, the efficacy of these dietary adjuncts is limited. Bile acid-binding resins are the only approved drugs to lower cholesterol levels in children and appear to be well tolerated. However, compliance with resins is low because of unpalatability, so low dosages are preferred and vitamin supplementation is prudent. Data on HMG CoA reductase inhibitors and fibrates are insufficient to recommend these drugs at present. Drug treatment should be restricted to children who are at exceptionally high risk of disease, usually those with genetic dyslipidaemias.
authors.affiliation: Ullevål Hospital, Oslo, Norway. serena.tonstad@rh.uio.no
authors.forename: S
authors.initials: S
authors.lastname: Tonstad
mesh_terms: D000837:Anion Exchange Resins / Q000378:metabolism; D000924:Anticholesteremic Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D001647:Bile Acids and Salts / Q000378:metabolism; D001665:Binding Sites; D002648:Child; D002675:Child, Preschool; D002784:Cholesterol / Q000097:blood; D018752:Diet, Fat-Restricted; D004043:Dietary Fiber / Q000008:administration & dosage; D005260:Female; D005395:Fish Oils / Q000008:administration & dosage / Q000627:therapeutic use; D017408:Guidelines as Topic; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D006937:Hypercholesterolemia / Q000178:diet therapy* / Q000188:drug therapy*; D007223:Infant; D008297:Male; D010840:Phytosterols / Q000008:administration & dosage / Q000627:therapeutic use; D018570:Risk Assessment
chemical_list: D000837:Anion Exchange Resins; D000924:Anticholesteremic Agents; D001647:Bile Acids and Salts; D004043:Dietary Fiber; D005395:Fish Oils; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D010840:Phytosterols; D002784:Cholesterol