Preoperative localization of parathyroid adenomas using 99mTc-MIBI scintigraphy in patients with hyperparathyroidism.
BACKGROUND
Technetium (Tc)99m methoxyisobutyl isonitrile (99mTc-MIBI) has recently been introduced for parathyroid imaging, as well as for myocardial imaging. We studied the usefulness of 99mTc-MIBI scintigraphy for preoperative localization of abnormal parathyroid glands.


METHODS
The usefulness of 99mTc-MIBI scintigraphy for detection of hyperfunctional parathyroid lesions was evaluated in 5 patients with primary hyperparathyroidism. The results of localizing the abnormal glands by using 99mTc-MIBI were compared with those obtained by using thallium (Tl) 201-technetium (Tc) 99m (201Tl-99mTc) subtraction scintigraphy, computed tomography, and ultrasonography.


RESULTS
The delayed (2 hours) imaging of 99mTc-MIBI scintigraphy was highly useful for accurate localization of the abnormal parathyroid lesions. The diseased glands were detected in all cases where 99mTc-MIBI scintigraphy was used, and using 99mTc-MIBI scintigraphy provided more information than did computed tomography, ultrasonography, or 201Tl-99mTc subtraction scintigraphy.


CONCLUSIONS
This method is simple and essential for detecting hyperfunctioning parathyroid glands, especially those with small or ectopic lesions. This technique should be widely applied as a localizing diagnostic method for hyperparathyroidism.
Ebisuno
S
S
Division of Urology, Minami Wakayama National Hospital, Japan.
Inagaki
T
T
Yoshida
T
T
Yamamoto
M
M
Tabuse
Y
Y
Kohjimoto
Y
Y
Ohkawa
T
T
D000236:Adenoma / Q000150:complications* / Q000000981:diagnostic imaging* / Q000601:surgery; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D006961:Hyperparathyroidism / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D010282:Parathyroid Neoplasms / Q000150:complications* / Q000000981:diagnostic imaging* / Q000601:surgery; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D013382:Subtraction Technique; D017256:Technetium Tc 99m Sestamibi; D013794:Thallium Radioisotopes; D014057:Tomography, X-Ray Computed
D019275:Radiopharmaceuticals; D013794:Thallium Radioisotopes; D017256:Technetium Tc 99m Sestamibi