Effect of molluscan neuropeptide RAPYFVamide on identified Helix pomatia L. neurons.
1. The effect of Mytilus inhibitory peptide-related peptide RAPYFVamide, isolated from Helix pomatia brain, was studied on 21 different identified Helix neurons. 2. It was found that the neuropeptide hyperpolarized 11 of the 21 neurons studied, inducing a K-dependent current. Not all neurons responded by hyperpolarization to the peptide application, though, in all cases the voltage-dependent outward K and inward Ca currents were depressed. 3. This may show that, in the peptide effect, more than one type of K conductance is involved. 4. It is proposed that RAPYFVamide may have a functional role in the modulation of the feeding behavior in H. pomatia.
Kiss
T
T
Department of Zoology, Hungarian Academy of Sciences, Tihany, Hungary.
Osipenko
O N
ON
D000595:Amino Acid Sequence; D000818:Animals; D015220:Calcium Channels / Q000187:drug effects; D005724:Ganglia / Q000187:drug effects / Q000502:physiology; D006372:Helix, Snails / Q000187:drug effects* / Q000502:physiology; D008969:Molecular Sequence Data; D009474:Neurons / Q000187:drug effects / Q000502:physiology; D009479:Neuropeptides / Q000494:pharmacology*; D018408:Patch-Clamp Techniques; D015221:Potassium Channels / Q000187:drug effects; D017386:Sequence Homology, Amino Acid
D015220:Calcium Channels; D009479:Neuropeptides; D015221:Potassium Channels; C107574:arginyl-alanyl-prolyl-tyrosyl-phenylalanyl-valinamide