New synthesis of delta 6-estrogens.
An efficient approach to synthesize delta 6-estrogens is described. The key steps in the synthesis are the introduction of a hydroxyl group at the C-6 position of a suitably protected estrogen using a superbase and subsequent dehydration with Martin sulfurane reagent or methyltriphenoxyphosphonium iodide. The two-step synthetic procedure readily gave the delta 6-estrogens in high yield.
Rao
P N
PN
Department of Organic Chemistry, Southwest Foundation for Biomedical Research, San Antonio, TX 78245-0549, USA.
Wang
Z
Z
D045166:Estradiol Congeners / Q000138:chemical synthesis* / Q000737:chemistry; D006894:Hydroxyestrones / Q000138:chemical synthesis / Q000737:chemistry; D008956:Models, Chemical
D045166:Estradiol Congeners; D006894:Hydroxyestrones