title: [Prevention and treatment of erectile disorders in sickle cell disease].
abstract: Priapism is a frequent and serious cause of morbidity in males with sickle cell disease. Acute priapism (AP) is preceeded in two-thirds of the cases by repeated minor events called stuttering priapism (SP). Since 1994, we have used a specific approach to prevent the commonly devastating effects of AP, using the alpha adrenergic agent etilefrine. Treatment of AP has been simplified (drainage without aspiration followed by one or two intracavernous injections (ICI) of 10 mg of etilefrine, until detumescence). For SP lasting more than one hour or causing pain, we use oral etilefrine and/or self ICI. This strategy was effective in five patients seen having AP, 21 patients with SP; it is simple, cheap, and avoids surgical procedure and transfusion. Moreover, erectile dysfunction, present in three patients, has been treated safely by ICI of protaglandins.
authors.affiliation: Centre de la drépanocytose, CHU Henri-Mondor, Créteil, France.
authors.forename: D
authors.initials: D
authors.lastname: Bachir
authors.forename: R
authors.initials: R
authors.lastname: Virag
authors.forename: K
authors.initials: K
authors.lastname: Lee
authors.forename: M
authors.initials: M
authors.lastname: Belloy
authors.forename: M
authors.initials: M
authors.lastname: de Montalembert
authors.forename: L
authors.initials: L
authors.lastname: Denis
authors.forename: A
authors.initials: A
authors.lastname: Broyart
authors.forename: R
authors.initials: R
authors.lastname: Girot
authors.forename: F
authors.initials: F
authors.lastname: Galactéros
mesh_terms: D000293:Adolescent; D000316:Adrenergic alpha-Agonists / Q000008:administration & dosage / Q000627:therapeutic use; D000328:Adult; D002648:Child; D002675:Child, Preschool; D005039:Etilefrine / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D008297:Male; D011317:Priapism / Q000503:physiopathology / Q000517:prevention & control / Q000628:therapy*; D012805:Sickle Cell Trait / Q000150:complications*; D013997:Time Factors
chemical_list: D000316:Adrenergic alpha-Agonists; D005039:Etilefrine