Delivery of medication by iontophoresis to treat post-burn hypertrophic scars: investigation of a new electronic technique.
At present, direct current (DC) and pulsed direct current (PDC) methods are used for iontophoresis. Although the DC field has high efficiency, it exhibits some side-effects. The PDC field has little side-effects, but the efficiency is lower. In this study, a new iontophoretic drug device was designed for providing the maximal efficiency with the minimal side-effects. Tests of animal and human models showed that the permeation rate of the new field was higher than that of PDC and DC fields, and side-effects were lower than that of the DC field.
Zhao
L
L
Department of Orthopaedics and Traumatology, Chinese University of Hong Kong, Shatin, Hong Kong.
Hung
L K
LK
Choy
T T
TT
D000279:Administration, Cutaneous; D000818:Animals; D002056:Burns / Q000150:complications*; D017439:Cicatrix, Hypertrophic / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D007478:Iontophoresis / Q000295:instrumentation / Q000379:methods*; D051381:Rats