[Telethermographic studies on the effect of immunoglobulins (Beriglobin) on heat radiation behavior in radiodermatitis].
BACKGROUND
Immunoglobulines are supposed to have a soothing effect on the degree of dermatitides and mucositides caused by irradiation. Research so far has been based on empiric information or reports of case studies mostly basing on subjective criteria. This study reports on objective thermographic measuring of heat radiation of dermatitides developing in the course of radiotherapy in case of female patients receiving postoperative radiotherapy after breast preserving operation on mamma carcinoma. Idea behind this is that immunglobulines affect inflammations of skin induced by irradiation, then also one of theses parameters, in this case heat, would be subject to change.


METHODS
Sixteen patients received 10 ml Beriglobin before first and 5 ml after 5th and 10th radiation (corresponds to 0 Gy, 10 Gy and 20 Gy) as intragluteal injection. Before starting with radiation as well as after 10 Gy respectively applied, upper bodies of patients were examined thermographically until final dose of 50 Gy was reached. Here temperature progress on upper body halves exposed to irradiation was compared with the untreated halves as well as with upper bodies of control group consisting of 20 patients who had received no immunoglobuline injections.


RESULTS
Patients who received immunoglobuline injections showed no differences in their skin temperature progress in comparison with the control group (Table 1, Figure 1). Skin temperature at the beginning as well as temperature progress during treatment and temperature at the end of treatment were identical in both groups. Also the relative temperature increase (temperature of body half subject to irradiation minus temperature of the other body half) was identical in both therapy groups (Table 2, Figure 2).


CONCLUSIONS
Immunoglobulines (Beriglobin) do not influence the course of thermal radiation due to dermatitis developing during a series of irradiation treatments. This results in the conclusion, that immunoglobulines do not have any influence in the vasodilative part of dermatitis and vasodilative redness respectively.
Proske
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Abteilung für Strahlentherapie der Philipps-Universität Marburg.
Pfab
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R
D000328:Adult; D000368:Aged; D001833:Body Temperature Regulation / Q000187:drug effects*; D001943:Breast Neoplasms / Q000150:complications / Q000628:therapy; D002081:Buttocks; D005260:Female; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage*; D007273:Injections, Intramuscular; D008875:Middle Aged; D011182:Postoperative Care; D011446:Prospective Studies; D011855:Radiodermatitis / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy*; D011879:Radiotherapy Dosage; D018714:Radiotherapy, Adjuvant; D013817:Thermography / Q000295:instrumentation / Q000379:methods
D016756:Immunoglobulins, Intravenous