title: Craniopharyngioma arising de novo in middle age. Case report.
abstract: The authors report the case of a 55-year-old woman who developed a symptomatic craniopharyngioma within 2 years of obtaining a normal magnetic resonance image of her brain. Craniopharyngiomas are histologically benign tumors. They are thought to arise from embryonic remnants of Rathke's pouch and sac and to manifest themselves clinically after a steady growth that commences in fetal life. To the authors' knowledge, this is the first report that documents a tumor arising de novo in the sixth decade of life. This report appears to challenge the concept of the origin and natural history of craniopharyngiomas.
authors.affiliation: Department of Neurosurgery, Mount Sinai Medical Center, New York New York 10029, USA. arginm01@doc.mssm.edu
authors.forename: M S
authors.initials: MS
authors.lastname: Arginteanu
authors.forename: K
authors.initials: K
authors.lastname: Hague
authors.forename: R
authors.initials: R
authors.lastname: Zimmerman
authors.forename: M J
authors.initials: MJ
authors.lastname: Kupersmith
authors.forename: J H
authors.initials: JH
authors.lastname: Shaiu
authors.forename: J
authors.initials: J
authors.lastname: Schaeffer
authors.forename: K D
authors.initials: KD
authors.lastname: Post
mesh_terms: D003397:Craniopharyngioma / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D010911:Pituitary Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery