[Acute poisoning by new psychotropic drugs].
New tricyclic antidepressants such as amineptine and tianeptine have mild toxic effects while amoxapine is very toxic. Poisoning with new selective serotonin reuptake inhibitor antidepressants or monoamine-oxidase inhibitors type A (toloxatone, moclobemide) is usually not severe, but life-threatening serotonin syndromes may appear in case of drug combination with antidepressants. Loxapine and clozapine poisoning may lead to death while risperidone intoxication has usually a rather benign course. Substituted benzamide neuroleptics (amisulpride, sultopride) may induce seizures, QT prolongation and torsades de pointes. New hypnotics such as zolpidem and zopiclone have a mild toxicity similar to that of benzodiazepines, but coma and respiratory depression are observed if other drugs or ethanol are ingested or in case of chronic hepatic or respiratory insufficiency.
Harry
P
P
Centre antipoisons régional des Pays de la Loire Réanimation médicale, CHU, Angers.
D000208:Acute Disease; D000929:Antidepressive Agents, Tricyclic / Q000009:adverse effects; D014150:Antipsychotic Agents / Q000009:adverse effects; D006801:Humans; D008996:Monoamine Oxidase Inhibitors / Q000009:adverse effects; D011041:Poisoning / Q000209:etiology*; D011619:Psychotropic Drugs / Q000009:adverse effects* / Q000145:classification; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects
D000929:Antidepressive Agents, Tricyclic; D014150:Antipsychotic Agents; D008996:Monoamine Oxidase Inhibitors; D011619:Psychotropic Drugs; D017367:Selective Serotonin Reuptake Inhibitors