title: Brain creatine kinase reaction rates and reactant concentrations during seizures in developing rats.
abstract: Brain creatine kinase (CK) catalyzed phosphorus fluxes between phosphocreatine (PCr) and ATP and changes in reactant concentrations were measured using [31P] nuclear magnetic resonance spectroscopy ([31P]NMR) before and during pentylenetetrazole-induced seizures in 7 and 21 day old rats. The CK rate constants measured before seizures were three times higher in the older than in the younger rats. The rate constants increased 60% during seizures in the older rats but did not change or decreased in the younger. Small decreases in PCr were seen during seizures at both ages. A small decrease in ATP was seen at 7 days but not at 21 days.
authors.affiliation: Department of Neurology, Children's Hospital, Boston, MA, USA.
authors.forename: D
authors.initials: D
authors.lastname: Holtzman
authors.forename: R
authors.initials: R
authors.lastname: Meyers
authors.forename: I
authors.initials: I
authors.lastname: Khait
authors.forename: F
authors.initials: F
authors.lastname: Jensen
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D000375:Aging / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000201:enzymology* / Q000254:growth & development*; D001923:Brain Chemistry / Q000502:physiology*; D003402:Creatine Kinase / Q000378:metabolism*; D004569:Electroencephalography; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D010433:Pentylenetetrazole; D010725:Phosphocreatine / Q000378:metabolism; D051381:Rats; D012640:Seizures / Q000139:chemically induced / Q000378:metabolism*
chemical_list: D010725:Phosphocreatine; D000255:Adenosine Triphosphate; D003402:Creatine Kinase; D010433:Pentylenetetrazole