[Congenital toxoplasmosis with hydrocephalus diagnosed in utero: outcome of treatment].
BACKGROUND
The neurological outcome for severe toxoplasmosis can be poor despite appropriate management.


METHODS
A maternal toxoplasma infection occurred at 16 weeks of amenorrhoea; prenatal diagnosis was attempted at 20 weeks, fetal infection was confirmed by mouse inoculation at the 30th week. Pyrimethamine plus sulfadiazine treatment was initiated. However, at 37 weeks of amenorrhoea, sonographic examination of the fetus detected hydrocephalus. Despite prompt ventriculo-peritoneal shunting after birth and medical treatment of toxoplasmosis, the neurological developmental outcome was complicated and prognosis is poor at 5 years of age.


CONCLUSIONS
This case shows that parents must be carefully warned about risks of a prenatal toxoplasmosis.
Cotty
F
F
Service de parasitologie-mycologie, hôpital Bretonneau, Tours, France.
Carpentier
M A
MA
Descamps
P
P
Perrotin
F
F
Richard-Lenoble
D
D
D000890:Anti-Infective Agents / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006849:Hydrocephalus / Q000150:complications* / Q000000981:diagnostic imaging / Q000601:surgery; D007231:Infant, Newborn; D011247:Pregnancy; D011739:Pyrimethamine / Q000627:therapeutic use; D013411:Sulfadiazine / Q000627:therapeutic use; D014125:Toxoplasmosis, Congenital / Q000150:complications* / Q000188:drug therapy; D016896:Treatment Outcome; D016216:Ultrasonography, Prenatal
D000890:Anti-Infective Agents; D013411:Sulfadiazine; D011739:Pyrimethamine