The relationship between weight and response to cholesterol-lowering diets in women.
OBJECTIVE
To determine whether factors related to body weight might influence the cholesterol lowering response to diet.


METHODS
Run-In diet followed by crossover to low fat diets; average response is reported.


METHODS
Sixty-three subjects (30 men and 33 women) with moderately elevated plasma cholesterol levels.


METHODS
Lipid and anthropometric measurements. Data were analyzed as a repeated measures analysis of variance with lipid lowering response in all combined cholesterol lowering diets compared to baseline.


RESULTS
LDL cholesterol lowering was significantly affected by BMI in women (P = 0.01) but not in men (P = 0.54). There was also a weak effect of waist-hip (W/H) ratio on response (P = 0.127) in women, with the lower responders having a higher W/H ratio but there was no effect of W/H ratio in men (P = 0.86).


CONCLUSIONS
These results suggest that overweight women with elevated plasma cholesterol may be less responsive to reducing their cholesterol levels with diet.
Hannah
J S
JS
Medlantic Research Institute, Washington, DC 20010-2933, USA.
Jablonski
K A
KA
Howard
B V
BV
D000328:Adult; D001824:Body Constitution; D015992:Body Mass Index; D001835:Body Weight; D002784:Cholesterol / Q000097:blood*; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D004032:Diet; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000178:diet therapy*; D008297:Male; D008875:Middle Aged; D014280:Triglycerides / Q000097:blood
D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D014280:Triglycerides; D002784:Cholesterol