[A review of pregnancy-induced analgesia].
Pregnancy-induced analgesia is of interest to anesthesiologists because of a general clinical impression that a parturient has a lowered requirement for anesthetics and analgesics. This fact may be mainly explained that endogenous analgesic mechanisms are stimulated by pregnancy. It has been suggested that stress activates natural pain-inhibitory systems mediated by endogenous opioid and non-opioid mechanism. Activation of intrinsic analgesia systems by stress is described based on a review of literature. This paper will give an overview of experimental and clinical studies regarding pregnancy-induced analgesia and will discuss mechanisms and potential implications for novel therapeutic approaches.
Iwasaki
H
H
Department of Anesthesiology, Sapporo Medical University, School of Medicine.
Namiki
A
A
D000698:Analgesia; D018685:Anesthetics, Inhalation / Q000493:pharmacokinetics; D000779:Anesthetics, Local / Q000494:pharmacology; D000818:Animals; D004558:Electric Stimulation; D005260:Female; D006801:Humans; D010525:Peripheral Nerves / Q000187:drug effects / Q000502:physiology; D011247:Pregnancy / Q000502:physiology*; D011650:Pulmonary Alveoli / Q000378:metabolism; D013312:Stress, Physiological / Q000503:physiopathology; D001615:beta-Endorphin / Q000502:physiology*
D018685:Anesthetics, Inhalation; D000779:Anesthetics, Local; D001615:beta-Endorphin