Discriminating among the discriminator bases of tRNAs.
Aminoacyl-tRNA synthetases must select their specific tRNAs from the 20 structurally similar tRNAs present in a cell. The discriminator base, at position 73 of the tRNA, is important for this selection but its effects on aminoacylation are variable depending on context. Recent structural studies provide insight into this variability.
Hou
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Department of Biochemistry and Molecular Pharmacology, Thomas Jefferson University, 233 South 10th Street, Philadelphia, PA 19107, USA. hou1@jeflin.tju.edu
D000604:Amino Acyl-tRNA Synthetases / Q000378:metabolism; D003460:Crystallization; D004926:Escherichia coli; D009690:Nucleic Acid Conformation; D011487:Protein Conformation; D012343:RNA, Transfer / Q000737:chemistry*; D013329:Structure-Activity Relationship; D015003:Yeasts
D012343:RNA, Transfer; D000604:Amino Acyl-tRNA Synthetases