Tolerability of nabumetone: a pilot in vitro study showing absence of injury to articular cartilage.
Nabumetone, a compound of the naphthylalkanone class, has shown considerable anti-inflammatory, analgesic and antipyretic effects, together with high systemic and organ-specific tolerability. Its reputation for tolerability has been increased by an in-vitro study evaluating the mature collagen metabolism's markers under nabumetone treatment, which shows that, nabumetone does not interfere with collagen synthesis. Therefore, unlike some nonsteroidal anti-inflammatory drugs, nabumetone might not be injurious to articular cartilage. This feature makes nabumetone even safer for long-term treatment of rheumatic and orthopaedic conditions.
Giordano
N
N
Institute of Medical Pathology, University of Siena, Italy.
Senesi
M
M
Battisti
E
E
Gonnelli
S
S
Franci
B
B
Campagna
M S
MS
Mattii
G
G
Palumbo
F
F
Gennari
C
C
D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects* / Q000493:pharmacokinetics; D002074:Butanones / Q000009:adverse effects* / Q000493:pharmacokinetics; D002358:Cartilage, Articular / Q000187:drug effects*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D000077430:Nabumetone; D010865:Pilot Projects; D011355:Prodrugs / Q000009:adverse effects* / Q000493:pharmacokinetics; D012216:Rheumatic Diseases / Q000188:drug therapy*; D013583:Synovial Membrane / Q000187:drug effects / Q000378:metabolism
D000894:Anti-Inflammatory Agents, Non-Steroidal; D002074:Butanones; D011355:Prodrugs; D000077430:Nabumetone