title: [Influence of sustained increases of arterial pressure on left ventricular dP/dt when the left ventricular diastolic pressure is kept constant].
abstract: OBJECTIVE
  To evaluate the influence of sustained elevations of arterial pressure on dP/dt values, while the left ventricular end diastolic pressure was kept constant.
  
  
  METHODS
  Thirteen anesthetized dogs, mechanically ventilated and submitted to thoracotomy and pharmacological autonomic block (atropine-0.5 mg/kg i.v. + oxprenolol-3 mg/kg i.v.) were studied. The arterial pressure elevation was obtained by mechanical constriction of the descending thoracic aorta. Analyses were made in control (C) situation and after two successive increments of arterial pressure, sustained for 10 min, called hypertension 1 (H1) and hypertension 2 (H2), respectively. The end diastolic left ventricular pressure was kept constant by utilization of a perfusion system connected to the left atria.
  
  
  RESULTS
  Heart rate did not change (C: 125 +/- 13.9 bpm; H1: 125 +/- 13.5 bpm; H2: 123 +/- 14.1 bpm; p > 0.05); the LVSP increased (C: 119 +/- 8.1 mmHg; H1: 142 +/- 7.9 mmHg; H2: 166 +/- 7.7 mmHg; p < 0.01); the AoDP increased (C: 89 +/- 11.6 mmHg; H1: 99 +/- 9.5 mmHg; H2: 120 +/- 11.8 mmHg; p < 0.01); the LVEDP (C: 6.2 +/- 2.48 mmHg; H1: 6.3 +/- 2.43 mmHg; H2:6.1 +/- 2.51 mmHg; p > 0.05) and the dP/dt (C: 3068 +/- 1057.1 mmHg/s; H1: 3112 +/- 995.7 mmHg/s; H2: 3086 +/- 979.5 mmHg/s; p > 0.05) did not change.
  
  
  CONCLUSIONS
  dP/dt values are not influenced by a sustained elevation of arterial pressure, when the end diastolic left ventricular pressure is kept constant.
authors.affiliation: Faculdade de Medicina de Botucatu, UNESP, Depto de Pediatria, Botucatu,SP.
authors.forename: J R
authors.initials: JR
authors.lastname: Fioretto
authors.forename: K
authors.initials: K
authors.lastname: Okoshi
authors.forename: P J
authors.initials: PJ
authors.lastname: Tucci
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000502:physiology*; D004285:Dogs; D006339:Heart Rate / Q000502:physiology; D009200:Myocardial Contraction / Q000502:physiology*; D016277:Ventricular Function, Left / Q000502:physiology*