title: A flexible magnetization transfer line shape derived from tissue experimental data.
abstract: To summarize and compare magnetization transfer data from biological tissues, a method was developed to extract the average absorption lineshape of the semi-solid pool directly from magnetization transfer experimental data along with the four other parameters that characterize the two-pool model of exchange. Magnetization transfer data for several biological tissues were analyzed using this method and the resulting "flexible" lineshapes were compared with super-Lorentzian and "Kubo-Tomita" lineshapes. The use of flexible lineshapes noticeably improves the fit of the two-pool model to the data. The derived flexible lineshapes of all the tissues analyzed are physically realistic and show remarkably consistent behavior.
authors.affiliation: Sunnybrook Health Science Center, Department of Medical Biophysics, Toronto, Ontario, Canada.
authors.forename: J G
authors.initials: JG
authors.lastname: Li
authors.forename: S J
authors.initials: SJ
authors.lastname: Graham
authors.forename: R M
authors.initials: RM
authors.lastname: Henkelman
mesh_terms: D000818:Animals; D001921:Brain; D002417:Cattle; D066298:In Vitro Techniques; D008099:Liver; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008954:Models, Biological; D008970:Molecular Weight; D018482:Muscle, Skeletal; D009900:Optic Nerve