title: Modification of atrioventricular nodal electrophysiology by selective radiofrequency delivery on the anterior or posterior approaches.
abstract: An analysis was made in 14 isolated and perfused rabbit hearts of the electrophysiological effects of selective radiofrequency (RF) delivery in the anterior (group I, n = 7) or posterior zone (group II, n = 7) of the Koch triangle, with the aim of modifying atrioventricular nodal (AVN) conduction without suppressing 1:1 transmission. After opening the right atrium, RF was delivered (0.5 W) with a 1-mm diameter unipolar electrode positioned in the selected zone until a prolongation of no less than 15% was obtained in the Wenckebach cycle length (WCL). Before and after (30 min) RF, anterograde and retrograde AVN refractoriness and conduction were evaluated, stimulating from the crista terminalis (CT), the interatrial septum (IAS), and from the RV epicardium. After RF, the following percentage increments were observed in group I: AH(CT) = 36% +/- 9%, AH(IAS) = 38% +/- 11%, WCL(CT) = 28% +/- 8%, WCL(IAS) = 22% +/- 6%, functional refractory period (FRP) of the AVN(CT) = 13% +/- 11%, FRP-AVN(IAS) = 13% +/- 8%, retrograde WCL = 20% +/- 19%, and retrograde FRPVA = 13% +/- 16%. The increments observed in group II and the significances of the differences with respect to group I were: AH(CT) = 11% +/- 14% (P < 0.01), AH(IAS) = 19% +/- 32% (NS), WCL(CT) = 42% +/- 14% (P < 0.05), WCL(IAS) = 42% +/- 16% (P < 0.01), FRP-AVN(CT) = 28% +/- 28% (NS), FRP-AVN(LAS) = 21% +/- 19% (NS), retrograde WCL = 35% +/- 24% (NS), and retrograde FRP = 16% +/- 13% (NS). In both groups, the AH interval variations were not correlated with those of the rest of the parameters analyzed. Truncated nodal function curves suggestive of a dual AV nodal pathway were obtained in three experiments, though in only one of them was this observed under basal conditions. In the other two experiments, with dual AV nodal physiology only after RF (one from each group), AV nodal reentrant tachycardias were triggered with atrial extrastimulus at coupling intervals equal to or shorter than at those that cause a sudden lengthening of the AH interval, RF delivered in the anterior and posterior zones of the Koch triangle produced effects of different magnitude on the AH interval and Wenckebach cycle length. In the anterior zone the AH interval was prolonged to a greater extent, while in the posterior zone the effects were greater on the Wenckebach cycle length. No correlation existed between the variations in AH interval and Wenckebach cycle length, regardless of where RF was delivered. The evaluation of anterograde AV nodal refractoriness was similar when stimulating from the crista terminalis or from the interatrial septum. By delivering RF, it was possible to induce dual AV nodal physiology and reentrant tachycardias.
authors.affiliation: Department of Medicine, Valencia University Medical School, Spain.
authors.forename: F J
authors.initials: FJ
authors.lastname: Chorro
authors.forename: J
authors.initials: J
authors.lastname: Sanchis
authors.forename: L
authors.initials: L
authors.lastname: Such
authors.forename: L
authors.initials: L
authors.lastname: Artal
authors.forename: J J
authors.initials: JJ
authors.lastname: Llavador
authors.forename: E
authors.initials: E
authors.lastname: Llavador
authors.forename: J V
authors.initials: JV
authors.lastname: Monmeneu
authors.forename: V
authors.initials: V
authors.lastname: López-Merino
mesh_terms: D000818:Animals; D001283:Atrioventricular Node / Q000502:physiology*; D017115:Catheter Ablation / Q000379:methods*; D004594:Electrophysiology; D066298:In Vitro Techniques; D011817:Rabbits; D012032:Refractory Period, Electrophysiological / Q000502:physiology; D013615:Tachycardia, Sinoatrial Nodal Reentry / Q000209:etiology