An assessment of the tumorigenic properties of a Hudson County soil sample heavily contaminated with hexavalent chromium.
During much of this century, Hudson County, New Jersey, was a major center for the processing of chromium ore. Some of the residue from this processing was used in landfills and in construction materials throughout the county and, in some cases, in highly populated areas. Given that it is widely accepted that exposure to hexavalent chromium compounds poses a risk for the development of respiratory-tract cancer, concerns were raised that individuals who worked or resided in chromium-contaminated areas might be at increased risk for the development of respiratory cancer. To address these concerns, we evaluated a Hudson County soil sample-heavily contaminated with chromium ore residue (Cr(+6) concentration at 5 895 mg/kg)-with respect to its carcinogenic potential to the respiratory tract of Sprague-Dawley rats. Groups of animals were given repeated intratracheal exposures to one of four materials: (1) Hudson County chromium-contaminated soil (CCS), (2) CCS augmented with calcium chromate (CaCrO4), (3) CaCrO4 alone, or (4) control soil. Nominal total doses of Cr(+6) for each respective group were 324 microg/kg, 7,975 microg/kg, 8,700 microg/kg, and 0.02 microg/kg. Incidences of malignant tumors and nephritis were not elevated in any group. Four primary lung tumors appeared in animals that received CCS + CaCrO4, and one primary lung tumor appeared in the group treated with CaCrO4 alone. These incidences were not significant statistically, but the rare spontaneous occurrence of these tumors in Sprague-Dawley rats suggested that they were treatment related. No primary lung tumors appeared in the control or CCS-treated groups.
Snyder
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New York University Institute of Environmental Medicine, Tuxedo, New York 10987, USA.
Sellakumar
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Waterman
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D000818:Animals; D017610:Calcium Compounds / Q000633:toxicity; D002273:Carcinogens; D002840:Chromates / Q000633:toxicity; D002857:Chromium / Q000633:toxicity*; D003627:Data Interpretation, Statistical; D008297:Male; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000473:pathology; D009393:Nephritis / Q000139:chemically induced / Q000473:pathology; D009515:New Jersey; D051381:Rats; D017207:Rats, Sprague-Dawley; D012307:Risk Factors; D012989:Soil Pollutants / Q000633:toxicity*; D013997:Time Factors
D017610:Calcium Compounds; D002273:Carcinogens; D002840:Chromates; D012989:Soil Pollutants; D002857:Chromium; C033750:calcium chromate(VI)