title: Potential of CT angiography in acute ischemic stroke.
abstract: OBJECTIVE
  To study the ability of CT angiography to show intracranial arterial occlusion and collateral blood flow in patients with acute stroke.
  
  
  METHODS
  Twenty-one patients with acute nonhemorrhagic stroke were studied prospectively with conventional CT, CT angiography, and digital subtraction angiography. On the basis of CT angiographic findings, two neuroradiologists independently assessed the site of arterial occlusion, the contrast enhancement in arterial branches beyond the occlusion as a measure of collateral blood supply, and the extent of diminished parenchymal enhancement; they then predicted the extent of ischemic infarction.
  
  
  RESULTS
  Both raters correctly assessed all trunk occlusions of the basilar artery (n = 4), the internal carotid artery (n = 4), and the middle cerebral artery (n = 9). The chance adjusted interrater agreement was kappa = .78. The assessment of branch occlusions of the middle cerebral artery was less reliable. The agreement rate in judging the collateral state in 17 occlusions in the anterior cerebral circulation was 88%. The size of 21 (62%) of 34 hemispheric infarctions was predicted correctly.
  
  
  CONCLUSIONS
  CT angiography quickly and reliably adds important information to conventional CT studies in cases of acute ischemic stroke. It shows the site of occlusion, the length of the occluded arterial segment, and the contrast-enhanced arteries beyond the occlusion as an estimate of collateral blood flow.
authors.affiliation: Department of Neuroradiology, University of Heidelberg Medical School, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Knauth
authors.forename: R
authors.initials: R
authors.lastname: von Kummer
authors.forename: O
authors.initials: O
authors.lastname: Jansen
authors.forename: S
authors.initials: S
authors.lastname: Hähnel
authors.forename: A
authors.initials: A
authors.lastname: Dörfler
authors.forename: K
authors.initials: K
authors.lastname: Sartor
mesh_terms: D000328:Adult; D000368:Aged; D015901:Angiography, Digital Subtraction / Q000295:instrumentation; D001921:Brain / Q000098:blood supply; D002545:Brain Ischemia / Q000000981:diagnostic imaging*; D002533:Cerebral Angiography / Q000295:instrumentation*; D002544:Cerebral Infarction / Q000000981:diagnostic imaging; D002561:Cerebrovascular Disorders / Q000000981:diagnostic imaging*; D003097:Collateral Circulation / Q000502:physiology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000295:instrumentation*; D008297:Male; D008578:Meninges / Q000098:blood supply; D008875:Middle Aged; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed / Q000295:instrumentation*; D014715:Vertebrobasilar Insufficiency / Q000000981:diagnostic imaging