title: [Relationship of prostatic carcinoma of the peripheral zone with glandular atrophy and prostatic intraepithelial neoplasia].
abstract: The study of the prostate's peripheral area in 32 patients, with age ranging between 48 to 75 years (mean, 61.4 +/- 6.7), demonstrates the frequency of certain morphological changes such as glandular atrophy (46.8%), which are neither related to age (p = 0.8) or the carcinoma (p = 0.8). A very different issue is the prostatic intraepithelial neoplasia, which although not statistically related to age in this series (p = 0.3) (probably due to the absence of young adults), appears to develop in earlier stages than cancer, is associated in 88.8% carcinomas (p = 0.03) and has a close topographic correlation to latent microscopic foci of adenocarcinoma of the prostate's peripheral area, anatomic proximity of both lesions occurring in 55.5% cases.
authors.affiliation: Sección de Anatomía Patológica, Fundació Puigvert, Universidad Autónoma de Barcelona.
authors.forename: F
authors.initials: F
authors.lastname: Algaba Arrea
authors.forename: I
authors.initials: I
authors.lastname: Trias Puig-Sureda
authors.forename: L
authors.initials: L
authors.lastname: López Duesa
authors.forename: J M
authors.initials: JM
authors.lastname: Rodríguez-Vallejo
authors.forename: J
authors.initials: J
authors.lastname: González-Esteban
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology*; D000368:Aged; D001284:Atrophy; D006801:Humans; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000473:pathology*; D011467:Prostate / Q000473:pathology*; D019048:Prostatic Intraepithelial Neoplasia / Q000473:pathology*; D011471:Prostatic Neoplasms / Q000473:pathology*