Axon sparing lesions of the medial preoptic area block female sexual behavior.
The role of the medial preoptic area (mPOA) in regulating female musk shrew sexual behavior was assessed with excitatory neurotoxin, N-methyl-D-aspartate (NMDA) lesions. Ovariectomized, testosterone-implanted females that received lesions in the mPOA were statistically less likely to show complete sex behavior as compared to controls. These data suggest that the mPOA plays an activational role in testosterone-induced female sexual behavior.
Veney
S L
SL
Department of Biology, University of Virginia, Charlottesville 22903, USA.
Rissman
E F
EF
D000818:Animals; D001369:Axons / Q000502:physiology* / Q000648:ultrastructure; D004343:Drug Implants; D005260:Female; D008297:Male; D016202:N-Methylaspartate / Q000494:pharmacology; D010052:Ovariectomy; D011301:Preoptic Area / Q000187:drug effects / Q000502:physiology* / Q000648:ultrastructure; D012726:Sexual Behavior, Animal / Q000502:physiology*; D012788:Shrews; D013739:Testosterone / Q000494:pharmacology
D004343:Drug Implants; D013739:Testosterone; D016202:N-Methylaspartate