Testis damage induced by zinc deficiency in rats.
Male Wistar rats were fed a Zn-deficient diet (1.2 mg/kg of Zn) for 28 days. Testes were then studied by light and electron microscopy. Zn deficiency induced necroses of precursors of germ cells leading to tubular atrophy and affected differentiation of spermatids. This was expressed by the occurrence of 2-4 axoneme-dense fibre-mitochondria complexes in one spermatid. Moreover, outer dense fibres, which normally contain 90% of sperm Zn, were "uncoiled" and flattened. The multiplication of the axoneme-dense fibre-mitochondria complexes induced by Zn deficiency might have been produced by an increase of Fe in spermatids and an increased formation of oxygen free radicals.
Merker
H J
HJ
Institute of Clinical Pharmacology and Toxicology, Free University of Berlin, Germany.
Günther
T
T
D000818:Animals; D001284:Atrophy; D002454:Cell Differentiation; D008297:Male; D008854:Microscopy, Electron; D008928:Mitochondria / Q000473:pathology / Q000648:ultrastructure; D009336:Necrosis; D051381:Rats; D017208:Rats, Wistar; D013087:Spermatids / Q000473:pathology; D013094:Spermatozoa / Q000473:pathology / Q000648:ultrastructure; D013737:Testis / Q000473:pathology* / Q000648:ultrastructure; D015032:Zinc / Q000172:deficiency*
D015032:Zinc