Identification of a chemokine receptor encoded by human cytomegalovirus as a cofactor for HIV-1 entry.
The human cytomegalovirus encodes a beta-chemokine receptor (US28) that is distantly related to the human chemokine receptors CCR5 and CXCR4, which also serve as cofactors for the entry into cells of human immunodeficiency virus-type 1 (HIV-1). Like CCR5, US28 allowed infection of CD4-positive human cell lines by primary isolates of HIV-1 and HIV-2, as well as fusion of these cell lines with cells expressing the viral envelope proteins. In addition, US28 mediated infection by cell line-adapted HIV-1 for which CXCR4 was an entry cofactor.
Pleskoff
O
O
Inserm U.332, Institut Cochin de Génétique Moléculaire, 22 rue Méchain, 75014 Paris, France.
Tréboute
C
C
Brelot
A
A
Heveker
N
N
Seman
M
M
Alizon
M
M
D017088:AIDS-Related Opportunistic Infections / Q000821:virology; D000595:Amino Acid Sequence; D002459:Cell Fusion; D018925:Chemokines; D018920:Coculture Techniques; D003587:Cytomegalovirus / Q000235:genetics* / Q000502:physiology; D003586:Cytomegalovirus Infections / Q000821:virology; D015726:Giant Cells; D015658:HIV Infections / Q000821:virology; D015497:HIV-1 / Q000502:physiology*; D015498:HIV-2 / Q000502:physiology*; D006367:HeLa Cells; D006801:Humans; D008565:Membrane Proteins / Q000502:physiology; D008969:Molecular Sequence Data; D054390:Receptors, CCR2; D019713:Receptors, CCR5; D019718:Receptors, CXCR4; D019707:Receptors, Chemokine; D018121:Receptors, Cytokine / Q000235:genetics / Q000502:physiology*; D015728:Receptors, HIV / Q000235:genetics / Q000502:physiology*; D014162:Transfection; D014407:Tumor Cells, Cultured; D014764:Viral Proteins / Q000235:genetics / Q000502:physiology*
C515334:CCR2 protein, human; D018925:Chemokines; D008565:Membrane Proteins; D054390:Receptors, CCR2; D019713:Receptors, CCR5; D019718:Receptors, CXCR4; D019707:Receptors, Chemokine; D018121:Receptors, Cytokine; D015728:Receptors, HIV; D014764:Viral Proteins