Blood amounts and suppressive in vitro activity of CD8+11b(+)-lymphocytes from HIV-infected children, related to hepatitis B or C virus association.
In HIV only, as well as in HIV/hepatitis B- and HIV/hepatitis C-infected children (6 to 8 years of age), with moderate altered clinical and immune cell markers, the total amounts of CD8(+)-set and of CD8+11b(+)-subset (T-suppressor) blood lymphocytes, by means of flow cytometry, were determined. On the other hand, within several mixtures of autologous sorted CD3+/CD8+11b(+)-cells, the per cent reduction of HLA-DR+ expression on T-cells, at different effector/responder cell ratios, was appreciated. Significant higher levels of CD8+11b(+)-cells, especially in HIV/hepatitis B virus groups, were found, that correlated with a stronger suppressive activity. The strongest alteration of immune markers, within HIV-seropositive, HBs+, HBe+ patients, was noticed. A possible usefulness of these data in HIV only, and in HIV-associated hepatitis B or C virus contamination, during pediatric AIDS monitoring, was commented.
Voiculescu
C
C
Faculty of Medicine in Craiova, Department of Microbiology and Immunology, Romania.
Avramescu
C
C
Radu
E
E
Bălăşoiu
M
M
Turculeanu
A
A
D015703:Antigens, CD / Q000032:analysis*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D002648:Child; D015658:HIV Infections / Q000150:complications* / Q000276:immunology*; D006679:HIV Seropositivity / Q000150:complications / Q000276:immunology*; D006509:Hepatitis B / Q000150:complications* / Q000276:immunology; D006514:Hepatitis B Surface Antigens / Q000097:blood; D006513:Hepatitis B e Antigens / Q000097:blood; D006526:Hepatitis C / Q000150:complications* / Q000276:immunology; D018937:Hepatitis C Antibodies / Q000097:blood; D006801:Humans; D018655:Lymphocyte Count; D016177:Macrophage-1 Antigen / Q000032:analysis*
D015703:Antigens, CD; D006514:Hepatitis B Surface Antigens; D006513:Hepatitis B e Antigens; D018937:Hepatitis C Antibodies; D016177:Macrophage-1 Antigen