Optimization of the electrostatic interactions between ionized groups and peptide dipoles in proteins.
The three-dimensional optimization of the electrostatic interactions between the charged amino acid residues and the peptide partial charges was studied by Monte-Carlo simulations on a set of 127 nonhomologous protein structures with known atomic coordinates. It was shown that this type of interaction is very well optimized for all proteins in the data set, which suggests that they are a valuable driving force, at least for the native side-chain conformations. Similar to the optimization of the charge-charge interactions (Spassov VZ, Karshikoff AD, Ladenstein R, 1995, Protein Sci 4:1516-1527), the optimization effect was found more pronounced for enzymes than for proteins without enzymatic function. The asymmetry in the interactions of acidic and basic groups with the peptide dipoles was analyzed and a hypothesis was proposed that the properties of peptide dipoles are a factor contributing to the natural selection of the basic amino acids in the chemical composition of proteins.
Spassov
V Z
VZ
Centre for Structural Biochemistry, Karolinska Institutet, NOVUM, Stockholm, Sweden.
Ladenstein
R
R
Karshikoff
A D
AD
D000596:Amino Acids / Q000737:chemistry*; D000599:Amino Acids, Diamino / Q000737:chemistry; D000600:Amino Acids, Dicarboxylic / Q000737:chemistry; D016208:Databases, Factual; D008956:Models, Chemical; D009010:Monte Carlo Method; D010455:Peptides / Q000737:chemistry*; D011506:Proteins / Q000737:chemistry*; D055672:Static Electricity
D000596:Amino Acids; D000599:Amino Acids, Diamino; D000600:Amino Acids, Dicarboxylic; D010455:Peptides; D011506:Proteins