title: Effects of quaternary ammonium compounds with 0.1% sodium hydroxide on swine vesicular disease virus.
abstract: The effects of quaternary ammonium compounds (QACs) with sodium hydroxide on swine vesicular disease virus (SVDV), an enterovirus were studied. Didecyldimethylammonium chloride (DDAC) with 0.1% NaOH showed a stronger effect against SVDV than other QACs with 0.1% NaOH. The effect of DDAC with 0.1% NaOH was strong at 40 degrees C. DDAC was effective against SVDV at pH values around 11.0, but not in the distilled water control. The effect of DDAC with 0.1% NaOH was already observed at 1 min after mixing of the DDAC with SVDV. Observation under an electron microscopy revealed that the probable mechanism of inactivation of DDAC with 0.1% NaOH is as follows: The virus particles were partially destroyed by 0.1% NaOH. DDAC gathered these affected particles and formed a micelle, then SVDV lost its infectivity. From these results, QACs with 0.1% NaOH are considered to be very effective against SVDV representing enteroviruses.
authors.affiliation: Department of Exotic Diseases, National Institute of Animal Health, Tokyo, Japan.
authors.forename: J
authors.initials: J
authors.lastname: Shirai
authors.forename: T
authors.initials: T
authors.lastname: Kanno
authors.forename: T
authors.initials: T
authors.lastname: Inoue
authors.forename: S
authors.initials: S
authors.lastname: Mitsubayashi
authors.forename: R
authors.initials: R
authors.lastname: Seki
mesh_terms: D000818:Animals; D002460:Cell Line; D004770:Enterovirus / Q000187:drug effects* / Q000502:physiology / Q000648:ultrastructure; D007700:Kinetics; D008854:Microscopy, Electron; D000644:Quaternary Ammonium Compounds / Q000494:pharmacology*; D012972:Sodium Hydroxide / Q000494:pharmacology*; D013552:Swine; D013555:Swine Vesicular Disease; D013997:Time Factors; D014779:Virus Replication / Q000187:drug effects*
chemical_list: D000644:Quaternary Ammonium Compounds; C053645:N,N-dimethyl-N-hexadecyl-1-octadecylammonium; D012972:Sodium Hydroxide