Pharmacological characterization of synaptic transmission through mGluRs in rat cerebellar slices.
The mGluR-mediated EPSP at parallel fibre-Purkinje cell synapses in the cerebellum was blocked concentration-dependently and reversibly by antagonists acting selectively on group-I mGluRs but not by an inhibitor of group-III receptors. The results provide pharmacological evidence that the receptor type responsible for the mGluR-EPSP is mGluR1.
Batchelor
A M
AM
The Cruciform Project, University College London, U.K.
Knöpfel
T
T
Gasparini
F
F
Garthwaite
J
J
D000818:Animals; D001565:Benzoates / Q000494:pharmacology*; D002531:Cerebellum / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology*; D005998:Glycine / Q000031:analogs & derivatives* / Q000494:pharmacology; D051381:Rats; D018094:Receptors, Metabotropic Glutamate / Q000187:drug effects*; D009435:Synaptic Transmission / Q000187:drug effects*
D001565:Benzoates; D018691:Excitatory Amino Acid Antagonists; D018094:Receptors, Metabotropic Glutamate; C079693:4-carboxyphenylglycine; D005998:Glycine