CSF IL-1 and IL-2 in medicated schizophrenic patients and normal volunteers.
It is clear that cytokines exert a variety of modulatory actions on the central nervous system. As part of our work exploring the relationship between immune activation and psychosis, we measured cerebrospinal fluid (CSF) IL-1 alpha and IL-2 levels in 60 medicated schizophrenic patients and in 21 normal volunteers using a competitive enzyme immunoassay. The two groups did not differ significantly in their mean cytokine levels: 1.01 (0.149) ng/ml (patients) vs. 1.28 (0.150) ng/ml (controls) for IL-1 alpha and 0.970 (0.038) ng/ml (patients) vs. 1.25 (0.086) ng/ml (controls) for IL-2. There was a significant positive correlation between CSF IL-1 alpha and IL-2 levels for all subjects (r = 0.50, n = 44, p = 0.0001).
Rapaport
M H
MH
Department of Psychiatry, University of California, San Diego, USA.
McAllister
C G
CG
Pickar
D
D
Tamarkin
L
L
Kirch
D G
DG
Paul
S M
SM
D000328:Adult; D005260:Female; D006801:Humans; D007375:Interleukin-1 / Q000134:cerebrospinal fluid* / Q000276:immunology; D007376:Interleukin-2 / Q000134:cerebrospinal fluid* / Q000276:immunology; D008297:Male; D012559:Schizophrenia / Q000188:drug therapy* / Q000276:immunology*
D007375:Interleukin-1; D007376:Interleukin-2