title: Creatine ingestion increases anaerobic capacity and maximum accumulated oxygen deficit.
abstract: The purpose of this study was to test the hypothesis that ingestion of creatine monohydrate increases anaerobic exercise capacity, as reflected by the maximal accumulated oxygen deficit (MAOD). Subjects were assigned, double-blind, to placebo (PL, n = 12) or creatine (CR, n = 14) groups and ingested 5-g doses 4 times daily of artificial sweetener or artificially sweetened creatine monohydrate, respectively, for 5 days. On a separate day subjects exercised to exhaustion at 125% VO2max. After two familiarization trials, MAOD was again determined before treatment, after 5 days of PL or CR treatment, and 7 days later. MAOD increased after CR treatment from 4.04 +/- 0.31 to 4.41 +/- 0.34 L (p < .001) and remained elevated for another 7 days (4.31 +/- 0.33, p < .001). Time to exhaustion also increased in CR from 130 +/- 7 to 141 +/- 7 s (p < .01) and remained increased for another 7 days (139 +/- 8 s, p < .01). These data demonstrate that ingesting creatine monohydrate for 5 days increases the MAOD, and is likely to have an ergogenic effect on supramaximal exercise performance that persists for at least a week after treatment.
authors.affiliation: Defence and Civil Institute of Environmental Medicine, North York, ON.
authors.forename: I
authors.initials: I
authors.lastname: Jacobs
authors.forename: S
authors.initials: S
authors.lastname: Bleue
authors.forename: J
authors.initials: J
authors.lastname: Goodman
mesh_terms: D000284:Administration, Oral; D000328:Adult; D015308:Anaerobic Threshold / Q000187:drug effects* / Q000502:physiology; D003401:Creatine / Q000494:pharmacology*; D004311:Double-Blind Method; D004734:Energy Metabolism / Q000187:drug effects* / Q000502:physiology; D015444:Exercise; D017079:Exercise Tolerance / Q000502:physiology*; D005260:Female; D006801:Humans; D000860:Hypoxia / Q000378:metabolism* / Q000503:physiopathology; D008297:Male; D011653:Pulmonary Diffusing Capacity; D012016:Reference Values; D013147:Spirometry
chemical_list: D003401:Creatine