title: Endectocidal efficacies of doramectin in naturally parasitized pigs.
abstract: The studies reported here were conducted to investigate the effectiveness of doramectin, given intramuscularly at the rate of 300 micrograms kg-1 of bodyweight, in the treatment of naturally acquired porcine nematodosis and acariasis. Twenty pigs demonstrated to be naturally infected with pulmonary and gastrointestinal nematodes were used in one control study, and 22 pigs demonstrated to be naturally parasitized with Sarcoptes scabiei var. suis were used in a second study. In both studies, animals were evenly divided between doramectin plus vehicle and vehicle-treated groups by restricted randomization. In the anthelmintic study, all pigs were necropsied for parasite collection on post-treatment Days 14 and 15. The acaricidal evaluation study was 28 days in duration after treatment, with mite population quantifications on the day of treatment and on post-treatment Days 7, 14, 21 and 28. Doramectin proved 100% effective in the removal of Metastrongylus salmi, M. elongatus, M. pudendotectus, Strongyloides ransomi, Ascaris suum and Oesophagostomum dentatum. Levels of Hyostrongylus rubidus, Ascarops strongylina and Macracanthorhynchus hirudinaceus, as observed at necropsy in the doramectin-treated pigs, were reduced by 99.2%, 99.5% and 62.1%, respectively, as compared with levels seen in the control pigs. In regard to Sarcoptes scabiei var. suis, no live mites were recovered from doramectin-treated pigs during the 7-28 day post-treatment period. In conclusion, doramectin proved highly effective in the treatment of naturally acquired porcine nematodosis and Sarcoptes scabiei var. suis infestation. In addition, all treatments were safe and well tolerated, with no adverse reactions noted in any trial animals.
authors.affiliation: Department of Animal Science, University of Arkansas, Fayetteville 72701, USA.
authors.forename: T A
authors.initials: TA
authors.lastname: Yazwinski
authors.forename: C
authors.initials: C
authors.lastname: Tucker
authors.forename: H
authors.initials: H
authors.lastname: Featherston
authors.forename: Z
authors.initials: Z
authors.lastname: Johnson
authors.forename: N
authors.initials: N
authors.lastname: Wood-Huels
mesh_terms: D000818:Animals; D000969:Antinematodal Agents / Q000627:therapeutic use*; D005260:Female; D007559:Ivermectin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D008297:Male; D009349:Nematode Infections / Q000188:drug therapy / Q000469:parasitology / Q000662:veterinary*; D012532:Scabies / Q000188:drug therapy / Q000469:parasitology / Q000662:veterinary*; D013552:Swine; D013553:Swine Diseases / Q000188:drug therapy* / Q000469:parasitology
chemical_list: D000969:Antinematodal Agents; D007559:Ivermectin; C084101:doramectin