Coexistence of mu-opioid receptor-like and substance P-like immunoreactivities in the cat dorsal root ganglionic neurons.
Coexistence of mu-opioid receptor (MOR)-like immunoreactivity (LI) and substance P (SP)-LI in the neurons of the cat dorsal root ganglia (DRG) was examined by a double immunofluorescence histochemical method. Approximately 91% of SP-LI neurons in the DRG showed MOR-LI. However, SP-LI was exhibited in approximately 28% of the neurons labeled with MOR-LI. These morphological findings indicated that the MOR exist on most of the primary afferent SP-containing terminals, and suggest that MOR may regulate SP release from the primary afferent terminals in the cat dorsal horn.
Lü
Y
Y
Department of Anatomy, Fourth Military Medical University Xi an, People's Republic of China.
Zheng
H X
HX
Ding
Y Q
YQ
Gong
L W
LW
Qin
B Z
BZ
Li
J S
JS
D000344:Afferent Pathways / Q000166:cytology; D000818:Animals; D002415:Cats; D005455:Fluorescent Antibody Technique; D005727:Ganglia, Spinal / Q000166:cytology*; D007150:Immunohistochemistry; D008297:Male; D009411:Nerve Endings / Q000648:ultrastructure; D009474:Neurons / Q000166:cytology*; D017450:Receptors, Opioid, mu / Q000032:analysis*; D013373:Substance P / Q000032:analysis*
D017450:Receptors, Opioid, mu; D013373:Substance P