title: Prevalence of sleep-disordered breathing in diastolic heart failure.
abstract: OBJECTIVE
  Sleep-disordered breathing (SDB) is common in congestive heart failure. While isolated diastolic heart failure (DHF) accounts for up to a third of all cases of congestive heart failure, the prevalence of SDB in DHF is unknown. We aim to determine the prevalence and characteristics of SDB in a group of patients with symptomatic DHF.
  
  
  METHODS
  Twenty subjects with symptomatic DHF (New York Heart Association class II or III) and isolated diastolic dysfunction on echocardiography were assessed with lung function tests, modified sleep and health questionnaire, and overnight polysomnography. Significant SDB was defined as an apnea/hypopnea index (AHI) > 10.
  
  
  RESULTS
  Thirteen female and seven male subjects (mean age, 65+/-6.0 years; mean body mass index (BMI), 28+/-3.2) were evaluated, of whom 17 (85%) had a diagnosis of hypertension. Overall sleep quality was poor, with fragmentation and frequent arousals associated with respiratory events. Fifty-five percent of the patients had significant SDB, mainly obstructive apneas. BMI and the prevalence of hypertension were similar in patients with and without SDB. The deceleration time, an index of diastolic dysfunction, was more prolonged in the group with SDB (236+/-40 ms vs 282+/-31 ms; p<0.05). As a group, a lower minimum percentage arterial oxygen saturation during sleep, but not the AHI was associated with more severe degree of diastolic dysfunction on echocardiogram, including a lower ratio between the early peak transmittal flow velocity and the late peak atrial systolic velocity (rho=0.57; p<0.05) and a prolonged isovolumic relaxation time (rho=-0.54; p<0.05).
  
  
  CONCLUSIONS
  SDB is common in patients with DHF. Patients with DHF and SDB may be associated with worse diastolic dysfunction than those without SDB, although a causal relationship remains to be established.
authors.affiliation: Department of Medicine, Prince of Wales Hospital, Shatin, NT, Hong Kong.
authors.forename: J
authors.initials: J
authors.lastname: Chan
authors.forename: J
authors.initials: J
authors.lastname: Sanderson
authors.forename: W
authors.initials: W
authors.lastname: Chan
authors.forename: C
authors.initials: C
authors.lastname: Lai
authors.forename: D
authors.initials: D
authors.lastname: Choy
authors.forename: A
authors.initials: A
authors.lastname: Ho
authors.forename: R
authors.initials: R
authors.lastname: Leung
mesh_terms: D000368:Aged; D003971:Diastole; D004452:Echocardiography / Q000379:methods / Q000706:statistics & numerical data; D015150:Echocardiography, Doppler / Q000379:methods / Q000706:statistics & numerical data; D005260:Female; D006333:Heart Failure / Q000150:complications* / Q000175:diagnosis; D006723:Hong Kong / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D017286:Polysomnography / Q000379:methods / Q000706:statistics & numerical data; D015995:Prevalence; D012891:Sleep Apnea Syndromes / Q000175:diagnosis / Q000453:epidemiology*; D018709:Statistics, Nonparametric; D011795:Surveys and Questionnaires