[Selective inhibitors of cyclooxygenase-2. New agents against pain and inflammation].
Peripherally active analgesics are considered to exert their effect by blocking the enzyme, cyclo-oxygenase (COX), thus inhibiting the biosynthesis both of prostaglandins and of thromboxanes. It was recently found that there are two enzymes which can form prostaglandins: COX-1 and COX-2. Whereas COX-1 is normally expressed in many tissues, expression of COX-2 can be induced in response to inflammation. New experimental findings in 'knockout' mice have suggested that subgrouping of cyclo-oxygenases as 'good' (COC-1) and 'bad' (COX-2) may be inappropriate. COX-2 specific NSAIDs (non-steroidal anti-inflammatory drugs) may be potent antiinflammatory and analgesic agents with no serious side-effects, though this has yet to be confirmed in clinical trials.
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Institutionen för farmaceutisk biovetenskap, Uppsala Universitet.
D000700:Analgesics / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D016861:Cyclooxygenase Inhibitors / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D006801:Humans; D051379:Mice
D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D016861:Cyclooxygenase Inhibitors