title: Intracellular targeting, interaction with Src homology 3 (SH3) domains and rolipram-detected conformational switches in cAMP-specific PDE4A phosphodiesterase.
authors.affiliation: Division of Biochemistry & Molecular Biology, IBLS, University of Glasgow, Scotland, U.K.
authors.forename: M D
authors.initials: MD
authors.lastname: Houslay
authors.forename: G
authors.initials: G
authors.lastname: Scotland
authors.forename: S
authors.initials: S
authors.lastname: Erdogan
authors.forename: E
authors.initials: E
authors.lastname: Huston
authors.forename: S
authors.initials: S
authors.lastname: Mackenzie
authors.forename: J F
authors.initials: JF
authors.lastname: McCallum
authors.forename: I
authors.initials: I
authors.lastname: McPhee
authors.forename: L
authors.initials: L
authors.lastname: Pooley
authors.forename: G
authors.initials: G
authors.lastname: Rena
authors.forename: A
authors.initials: A
authors.lastname: Ross
authors.forename: M
authors.initials: M
authors.lastname: Beard
authors.forename: A
authors.initials: A
authors.lastname: Peder
authors.forename: F
authors.initials: F
authors.lastname: Begg
authors.forename: I
authors.initials: I
authors.lastname: Wilkinson
authors.forename: S
authors.initials: S
authors.lastname: Yarwood
authors.forename: C
authors.initials: C
authors.lastname: Ackerman
authors.forename: E S
authors.initials: ES
authors.lastname: Houslay
authors.forename: R
authors.initials: R
authors.lastname: Hoffman
authors.forename: P
authors.initials: P
authors.lastname: Engels
authors.forename: M
authors.initials: M
authors.lastname: Sullivan
authors.forename: G
authors.initials: G
authors.lastname: Bolger
mesh_terms: D015105:3',5'-Cyclic-AMP Phosphodiesterases; D017398:Alternative Splicing; D000595:Amino Acid Sequence; D000818:Animals; D002878:Chromosomes, Human, Pair 1; D002895:Chromosomes, Human, Pair 5; D000242:Cyclic AMP / Q000378:metabolism; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4; D006801:Humans; D007527:Isoenzymes / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000235:genetics; D007700:Kinetics; D008969:Molecular Sequence Data; D005810:Multigene Family; D010726:Phosphodiesterase Inhibitors / Q000494:pharmacology*; D010727:Phosphoric Diester Hydrolases / Q000737:chemistry* / Q000235:genetics* / Q000378:metabolism; D011487:Protein Conformation; D011760:Pyrrolidinones / Q000494:pharmacology*; D051381:Rats; D020889:Rolipram; D018909:src Homology Domains
chemical_list: D007527:Isoenzymes; D010726:Phosphodiesterase Inhibitors; D011760:Pyrrolidinones; D000242:Cyclic AMP; D010727:Phosphoric Diester Hydrolases; D015105:3',5'-Cyclic-AMP Phosphodiesterases; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4; C517355:PDE4A protein, human; D020889:Rolipram