Abnormal ventricular repolarization mimicking myocardial infarction after heterocyclic antidepressant overdose.
In 2 young adult women who experienced acute heterocyclic antidepressant intoxication, we found a quite unusual electrocardiographic pattern characterized by abnormal ST-tract elevation in the right precordial leads associated with a marked QRS widening (right bundle branch block and left anterior fascicular block type). Because serum electrolyte imbalance and acute myocardial ischemic events were excluded, the mechanism by which antidepressant overdose may produce such elevation of the ST tract remains unclear.
Bolognesi
R
R
Cattedra di Cardiologia, Università degli Studi di Parma, Italy.
Tsialtas
D
D
Vasini
P
P
Conti
M
M
Manca
C
C
D000328:Adult; D000639:Amitriptyline / Q000506:poisoning; D014151:Anti-Anxiety Agents / Q000506:poisoning; D000928:Antidepressive Agents / Q000506:poisoning*; D000929:Antidepressive Agents, Tricyclic / Q000506:poisoning; D014150:Antipsychotic Agents / Q000506:poisoning; D001569:Benzodiazepines; D002037:Bundle-Branch Block / Q000139:chemically induced / Q000175:diagnosis*; D003937:Diagnosis, Differential; D003975:Diazepam / Q000506:poisoning; D004562:Electrocardiography / Q000187:drug effects; D005260:Female; D006352:Heart Ventricles / Q000187:drug effects; D006801:Humans; D006993:Hypnotics and Sedatives / Q000506:poisoning; D008133:Long QT Syndrome / Q000139:chemically induced / Q000175:diagnosis*; D008376:Maprotiline / Q000506:poisoning; D009203:Myocardial Infarction / Q000175:diagnosis*; D003708:Nordazepam / Q000031:analogs & derivatives / Q000506:poisoning; D010546:Perphenazine / Q000506:poisoning; D014229:Triazolam / Q000506:poisoning
D014151:Anti-Anxiety Agents; D000928:Antidepressive Agents; D000929:Antidepressive Agents, Tricyclic; D014150:Antipsychotic Agents; D006993:Hypnotics and Sedatives; D001569:Benzodiazepines; D000639:Amitriptyline; D014229:Triazolam; D008376:Maprotiline; D003708:Nordazepam; D010546:Perphenazine; C013434:chlordesmethyldiazepam; D003975:Diazepam