[Gutron studied as an agent for preventing radiation lesions].
Experimentally, with the use of mathematical modeling, a radioprotective effect and optimum usage of alpha-adrenomimetic Gutron was shown on CBA male-mice exposed to radiation. Injections of 1 to 5 mg/kg Gutron to the mice 10 to 40 min and 1 to 4 h before the irradiation with the doses of 6 to 7.5 Gy ensured the survival rates of the exposed animals with the protection coefficient s of 0.6 to 0.7 and 0.4, respectively.
Boĭko
V N
VN
Smirnova
S M
SM
Petrov
A S
AS
Antushevich
A E
AE
D000316:Adrenergic alpha-Agonists / Q000627:therapeutic use*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004307:Dose-Response Relationship, Radiation; D004353:Drug Evaluation, Preclinical; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D008879:Midodrine / Q000627:therapeutic use*; D011833:Radiation Injuries, Experimental / Q000401:mortality / Q000517:prevention & control*; D011837:Radiation-Protective Agents / Q000627:therapeutic use*; D012107:Research Design; D013997:Time Factors
D000316:Adrenergic alpha-Agonists; D011837:Radiation-Protective Agents; D008879:Midodrine