Changes in extracellular brain ascorbate in rat striatum in response to administration of non-volatile anaesthetic agents.
We used constant potential in vivo voltammetry to measure changes in striatal ascorbate in the rat in response to i.p. administration of several non-volatile anaesthetics. Propofol and pentobarbitone, which enhance GABA-mediated neuronal inhibitions, decreased ascorbate current to 27.0 (SEM 7.4) % and 46 (6) % of control, respectively. Chloral hydrate, diazepam alone or with ketamine, and fentanyl-fluanisone with midazolam produced no changes in ascorbate current.
Miele
M
M
University Laboratory of Physiology, Oxford, UK.
Fillenz
M
M
D018686:Anesthetics, Intravenous / Q000494:pharmacology*; D000818:Animals; D001205:Ascorbic Acid / Q000378:metabolism*; D015415:Biomarkers; D003342:Corpus Striatum / Q000187:drug effects* / Q000378:metabolism*; D005110:Extracellular Space / Q000378:metabolism; D008297:Male; D010424:Pentobarbital / Q000494:pharmacology; D015742:Propofol / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley
D018686:Anesthetics, Intravenous; D015415:Biomarkers; D010424:Pentobarbital; D001205:Ascorbic Acid; D015742:Propofol