title: Organization of the Drosophila genome in mutants with changes in second messenger metabolism and learning ability.
abstract: Mechanisms modifying the structural-functional organization of polytene chromosomes were studied in a Drosophila line in which the activating properties of calmodulin were altered and learning ability was increased, by treating mutants with homeopathic preparations which affect Ca2+ and F- ion metabolism. The results indicated a dominant role for Ca2+ ions and calmodulin in determining the chromocentric organization of the nucleus. F- ions, which stimulate the adenylate cyclase complex, were found not to have a role.
authors.affiliation: Laboratory of Comparative Behavioral Genetics, I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg.
authors.forename: A V
authors.initials: AV
authors.lastname: Medvedeva
authors.forename: E V
authors.initials: EV
authors.lastname: Tokmacheva
authors.forename: E V
authors.initials: EV
authors.lastname: Savvateeva
authors.forename: V S
authors.initials: VS
authors.lastname: Kornitskii
mesh_terms: D000818:Animals; D002147:Calmodulin / Q000235:genetics / Q000378:metabolism; D002875:Chromosomes / Q000648:ultrastructure; D004330:Drosophila; D004789:Enzyme Activation / Q000235:genetics; D017344:Genes, Insect; D016678:Genome; D007858:Learning / Q000502:physiology*; D009154:Mutation / Q000235:genetics*; D015290:Second Messenger Systems / Q000235:genetics*
chemical_list: D002147:Calmodulin