title: Intrarenal hemodynamic abnormalities in diabetic nephropathy measured by duplex Doppler sonography.
abstract: Intrarenal hemodynamics were studied by duplex Doppler sonography in 112 inpatients with type II diabetes mellitus (DM; 65 males, 47 females, 58 +/- 13 years old). The resistive index (RI) and pulsatility index (PI) of the interlobar arteries were calculated. The patients were divided into four groups: group I consisted of patients with urinary albumin excretion (UAE) < 20 micrograms/min (N = 42), group II with 20 < or = UAE < 200 (N = 28), group III with UAE > or = 200 (N = 25), and group IV with serum creatinine > or = 1.5 mg/dl (N = 17). Both RI and PI values in groups II, III, and IV were significantly higher than those in the controls (age- and sex-matched healthy persons, N = 37; P < 0.001), and those in group IV were significantly higher than those in groups I, II, and III (P < 0.0001). Multiple regression analysis revealed that RI values in DM patients were significantly affected by creatinine clearance, age, and duration of diabetes (R2 = 0.554, P < 0.0001). When intima-medial thickness (IMT) of the femoral and carotid arteries were measured by B-mode ultrasonography, RI values were significantly correlated with both the femoral and carotid arterial IMT. These results demonstrate that intrarenal hemodynamic abnormalities are present in type II DM patients with nephropathy, and that intrarenal hemodynamics are affected by decreased glomerular function and also probably by advanced arteriosclerosis.
authors.affiliation: Second Department of Internal Medicine, Osaka City University Medical School, Japan.
authors.forename: E
authors.initials: E
authors.lastname: Ishimura
authors.forename: Y
authors.initials: Y
authors.lastname: Nishizawa
authors.forename: T
authors.initials: T
authors.lastname: Kawagishi
authors.forename: Y
authors.initials: Y
authors.lastname: Okuno
authors.forename: K
authors.initials: K
authors.lastname: Kogawa
authors.forename: S
authors.initials: S
authors.lastname: Fukumoto
authors.forename: K
authors.initials: K
authors.lastname: Maekawa
authors.forename: M
authors.initials: M
authors.lastname: Hosoi
authors.forename: M
authors.initials: M
authors.lastname: Inaba
authors.forename: M
authors.initials: M
authors.lastname: Emoto
authors.forename: H
authors.initials: H
authors.lastname: Morii
mesh_terms: D000368:Aged; D002339:Carotid Arteries / Q000000981:diagnostic imaging / Q000503:physiopathology; D003928:Diabetic Nephropathies / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D005260:Female; D005263:Femoral Artery / Q000000981:diagnostic imaging / Q000503:physiopathology; D006439:Hemodynamics; D006801:Humans; D008297:Male; D008875:Middle Aged; D011674:Pulse; D012016:Reference Values; D012077:Renal Artery / Q000503:physiopathology; D012079:Renal Circulation; D017539:Tunica Intima / Q000000981:diagnostic imaging; D017540:Tunica Media / Q000000981:diagnostic imaging; D018616:Ultrasonography, Doppler, Duplex; D014655:Vascular Resistance