title: Assessment of breast cancer with dynamic gadolinium-enhanced MR imaging combined with magnetization transfer contrast using a newly developed breast surface coil for the supine position.
abstract: To assess the value of dynamic gadolinium-enhanced MR imaging combined with magnetization transfer contrast (MTC) of breast cancer by SPGR sequence, 15 patients with breast cancer were imaged in the supine position with the newly developed breast coil in a 1.5 Tesla imager. Dynamic gadolinium-enhanced MR imaging combined with MTC (10 cases) and conventional dynamic gadolinium-enhanced MR imaging (5 cases) were performed after the administration of Gd-DTPA (0.2 ml/kg). Sagittal images were obtained every 22 seconds during the first 264 seconds. Thus, a total of 15 images were obtained in each lesion. The signal intensity ratio (SIR) of lesion to mammary glarid was calculated for each image as follows: (SI lesion/SI mammary gland)/(SI (pre)lesion/SI (pre)mammary gland). Dynamic gadolinium-enhanced MR imaging with MTC always allowed better SIR at 88 seconds than conventional dynamic gadolinium-enhanced MR imaging after bolus injection (p < 0.01). Dynamic gadolinium-enhanced MR imaging with MTC improved detection of the boundary of the lesion and mammary gland.
authors.affiliation: First Department of Radiology, Toho University School of Medicine, Tokyo, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Shimada
authors.forename: A
authors.initials: A
authors.lastname: Senoo
authors.forename: S
authors.initials: S
authors.lastname: Hayashi
authors.forename: H
authors.initials: H
authors.lastname: Moriya
authors.forename: T
authors.initials: T
authors.lastname: Nanba
authors.forename: T
authors.initials: T
authors.lastname: Kogure
authors.forename: H
authors.initials: H
authors.lastname: Nakayama
authors.forename: M
authors.initials: M
authors.lastname: Nakagome
authors.forename: K
authors.initials: K
authors.lastname: Ito
authors.forename: I
authors.initials: I
authors.lastname: Kaneko
authors.forename: M
authors.initials: M
authors.lastname: Tsubuku
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000175:diagnosis*; D003287:Contrast Media / Q000008:administration & dosage; D005260:Female; D005682:Gadolinium / Q000008:administration & dosage; D006801:Humans; D007089:Image Enhancement; D008279:Magnetic Resonance Imaging / Q000295:instrumentation*; D008875:Middle Aged; D004369:Pentetic Acid / Q000008:administration & dosage; D012680:Sensitivity and Specificity; D016683:Supine Position
chemical_list: D003287:Contrast Media; D004369:Pentetic Acid; D005682:Gadolinium