title: Neovaginal malignant melanoma following surgery and radiation for vulvar squamous cell carcinoma.
abstract: The causal link between therapeutic irradiation and malignant melanoma has not been firmly established. The authors report a novel case of a malignant melanoma arising from a therapeutically irradiated neovagina reconstructed from skin flaps following radical vulvectomy with inguinal lymph node dissection 16 years earlier. The diagnosis was established by light microscopy and immunohistochemical staining. Reports of melanoma arising from sites of previous radiation therapy are reviewed. Our observations suggest that therapeutic radiation may be a factor in the development of malignant melanoma, particularly in non-sun-exposed areas, including the genital tract.
authors.affiliation: Division of Hematology-Oncology, University of California Davis Cancer Center, Sacramento 95817, USA.
authors.forename: P N
authors.initials: PN
authors.lastname: Lara
authors.forename: E
authors.initials: E
authors.lastname: Hearn
authors.forename: B
authors.initials: B
authors.lastname: Leigh
mesh_terms: D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000000981:diagnostic imaging* / Q000601:surgery; D005260:Female; D006801:Humans; D008545:Melanoma / Q000209:etiology*; D009381:Neoplasms, Radiation-Induced; D016609:Neoplasms, Second Primary / Q000209:etiology*; D011859:Radiography; D014625:Vaginal Neoplasms / Q000209:etiology*; D014846:Vulvar Neoplasms / Q000000981:diagnostic imaging* / Q000601:surgery