title: Galparan induces in vivo acetylcholine release in the frontal cortex.
abstract: The chimeric peptide galparan (galanin(1-13)-mastoparan) induced the in vivo release of acetylcholine in the frontal cortex of rats when injected intracerebroventricularly, i.c.v. The ACh-releasing effects of galparan are reversible, dose-dependent, and not exerted at galanin receptors or at sites where mastoparan acts. Pertussis toxin pretreatment (i.c.v.) of the rats for 96 h prior to injection of galparan or of mastoparan completely prevented the ACh-releasing effects of both galparan and mastoparan. It appears that galparan acts at a novel site in the release of ACh in the cerebral cortex in vivo.
authors.affiliation: Mario Negri Institute of Pharmacological Research, City, Milan, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Consolo
authors.forename: G
authors.initials: G
authors.lastname: Baldi
authors.forename: L
authors.initials: L
authors.lastname: Nannini
authors.forename: M C
authors.initials: MC
authors.lastname: Uboldi
authors.forename: M
authors.initials: M
authors.lastname: Pooga
authors.forename: U
authors.initials: U
authors.lastname: Langel
authors.forename: T
authors.initials: T
authors.lastname: Bartfai
mesh_terms: D000109:Acetylcholine / Q000378:metabolism*; D000818:Animals; D004338:Drug Combinations; D005110:Extracellular Space / Q000378:metabolism; D005625:Frontal Lobe / Q000187:drug effects* / Q000378:metabolism*; D019004:Galanin / Q000494:pharmacology; D036341:Intercellular Signaling Peptides and Proteins; D008297:Male; D010455:Peptides; D037342:Pertussis Toxin; D051381:Rats; D011919:Rats, Inbred Strains; D011993:Recombinant Fusion Proteins / Q000494:pharmacology*; D010566:Virulence Factors, Bordetella / Q000494:pharmacology; D014862:Wasp Venoms / Q000494:pharmacology
chemical_list: D004338:Drug Combinations; D036341:Intercellular Signaling Peptides and Proteins; D010455:Peptides; D011993:Recombinant Fusion Proteins; D010566:Virulence Factors, Bordetella; D014862:Wasp Venoms; C107160:galparan; C037500:mastoparan; D019004:Galanin; D037342:Pertussis Toxin; D000109:Acetylcholine