[The effect of a vaccinal strain of the plague microbe on C3-receptor expression on the surfaces of peritoneal and alveolar macrophages].
The work is devoted to the effect of vaccine strain of the plague microbe on the expression of C3-receptors (C3R) in interaction with macrophages in vitro and in vivo. It is established that the activation of macrophages accompanied by the increase of C3R expression on the external surface of the membrane of both peritoneal and alveolar macrophages occurs in the process of formation of antiplague immunity. Maximum activity of C3R in the both populations of macrophages is observed on the 7th day after vaccination. Immunization of the plague microbe by the vaccine strain does not change the character of response of peritoneal and alveolar macrophages to their interaction with this microorganism in vitro: a decrease of C3R expression on the surface of the both populations of cells obtained from both intact and immunized animals is observed. Heterogeneity of the studied populations as to C3R expression both in the intact and immune organism is detected.
Vasil'eva
G I
GI
Tkachenko
L N
LN
Doroshenko
E P
EP
Gamleshko
Kh P
KhP
Balatskaia
T A
TA
D000818:Animals; D003176:Complement C3 / Q000276:immunology*; D015964:Gene Expression Regulation, Bacterial / Q000276:immunology*; D006168:Guinea Pigs; D007114:Immunization; D008262:Macrophage Activation / Q000276:immunology; D016676:Macrophages, Alveolar / Q000276:immunology*; D017737:Macrophages, Peritoneal / Q000276:immunology*; D010931:Plague Vaccine / Q000235:genetics / Q000276:immunology*; D011951:Receptors, Complement / Q000276:immunology*; D012397:Rosette Formation; D013499:Surface Properties; D013997:Time Factors; D015010:Yersinia pestis / Q000235:genetics / Q000276:immunology*
D003176:Complement C3; D010931:Plague Vaccine; D011951:Receptors, Complement