title: Multifocal plasmacytoma of hand and foot bones.
abstract: Simultaneous occurrence of localized plasmacytomas of both hands and feet has not been reported so far. Here we report a 40-year old female patient, who had at presentation pain and deformity. Of hands and feet, with numerous cystic lytic lesions of phalangeal, metacarpal and metatarsal bones, detected by X-rays. The biopsy of the affected bone showed moderately differentiated plasmacytoma of lambda light chain type (lambda-LC). Serum and urine biochemical analysis revealed the existence of lambda LC monoclonal component. The patient was treated by local radiotherapy and subsequent systemic chemotherapy, which consisted of 3 cycles of the M-2 protocol and 7 cycles of melphalan-prednisone. Five years after the diagnosis, the absence of plasmacytoma was confirmed by puncture biopsy of the left hand phalanx. Monoclonal protein in serum and urine was not detected.
authors.affiliation: Institute of Haematology, Clinical Center of Serbia, Belgrade, Yugoslavia.
authors.forename: N
authors.initials: N
authors.lastname: Antonijevic
authors.forename: N
authors.initials: N
authors.lastname: Radosevic-Radojkovic
authors.forename: M
authors.initials: M
authors.lastname: Colovic
authors.forename: V
authors.initials: V
authors.lastname: Jovanovic
authors.forename: Z
authors.initials: Z
authors.lastname: Rolovic
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001859:Bone Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000532:radiotherapy; D002330:Carmustine / Q000008:administration & dosage; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000008:administration & dosage; D005260:Female; D005385:Fingers; D005534:Foot Diseases / Q000188:drug therapy / Q000473:pathology* / Q000532:radiotherapy; D006227:Hand Deformities, Acquired / Q000188:drug therapy / Q000473:pathology* / Q000532:radiotherapy; D006801:Humans; D008558:Melphalan / Q000008:administration & dosage; D008663:Metacarpus; D010954:Plasmacytoma / Q000188:drug therapy / Q000473:pathology* / Q000532:radiotherapy; D011241:Prednisone / Q000008:administration & dosage; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D014750:Vincristine; D003520:Cyclophosphamide; D008558:Melphalan; D002330:Carmustine; D011241:Prednisone