title: Adrenomedullary secretion of epinephrine is increased in mild essential hypertension.
abstract: To assess whether patients with mild essential hypertension have excessive activities of the sympathoneuronal and adrenomedullary systems, we examined total body and forearm spillovers and norepinephrine and epinephrine clearances in 47 subjects with mild essential hypertension (25 men, 22 women, aged 38.1 +/- 6.7 years) and 43 normotensive subjects (19 men, 24 women, aged 36.5 +/- 5.9 years). The isotope dilution method with infusions of tritiated norepinephrine and epinephrine was used at rest and during sympathetic stimulation by lower body negative pressure at -15 and -40 mm Hg. Hypertensive subjects had a higher arterial plasma epinephrine concentration (0.20 +/- 0.01 nmol.L-1: mean +/- SE) than normotensive subjects (0.15 +/- 0.01) (P < .01). The increased arterial plasma epinephrine levels appeared to be due to a higher total body epinephrine spillover rate in the hypertensive subjects (0.23 +/- 0.02 nmol.min-1.m-2) than the normotensive subjects (0.18 +/- 0.01) (P < .05) and not to a decreased plasma clearance of epinephrine. The arterial plasma norepinephrine level, total body and forearm norepinephrine spillover rates, and plasma norepinephrine clearance were not altered in the hypertensive subjects. The responses of the catecholamine kinetic variables to lower body negative pressure were not consistently different between normotensive and hypertensive individuals. These data indicate that individuals with mild essential hypertension (1) have elevated arterial plasma epinephrine concentrations that are due to an increased total body epinephrine spillover rate, indicating an increased adrenomedullary secretion of epinephrine; (2) have no increased generalized sympathoneuronal activity and no increased forearm norepinephrine spillover; and (3) have similar responses of both the sympathoneuronal and adrenomedullary systems to sympathetic stimulation by lower body negative pressure.
authors.affiliation: Department of Medicine, St Radboud University Hospital, Nijmegen, Netherlands.
authors.forename: M C
authors.initials: MC
authors.lastname: Jacobs
authors.forename: J W
authors.initials: JW
authors.lastname: Lenders
authors.forename: J J
authors.initials: JJ
authors.lastname: Willemsen
authors.forename: T
authors.initials: T
authors.lastname: Thien
mesh_terms: D000313:Adrenal Medulla / Q000378:metabolism*; D000328:Adult; D001794:Blood Pressure; D004837:Epinephrine / Q000097:blood / Q000378:metabolism* / Q000493:pharmacokinetics*; D005260:Female; D005542:Forearm / Q000098:blood supply; D006801:Humans; D006973:Hypertension / Q000378:metabolism*; D008297:Male; D009638:Norepinephrine / Q000097:blood / Q000493:pharmacokinetics*
chemical_list: D009638:Norepinephrine; D004837:Epinephrine