title: Short-term antihypertensive medication does not exacerbate sleep-disordered breathing in newly diagnosed hypertensive patients.
abstract: It has been speculated for some time that various antihypertensive medications may have a deleterious effect on respiration during sleep and thereby enhance the apparent association between hypertension and sleep apnea/hypopnea (SAH). However, there are few data to support this contention. The present study used a double-blind, randomized, cross-over design to contrast the effects of 6 weeks treatment with alpha-methyldopa and the combination of hydrochlorothiazide and amiloride with that of amlodipine and the combined diuretics in a group of 24 newly diagnosed patients with primary hypertension. All-night polysomnography was performed before the initiation of therapy (baseline) and at the end of the two treatment periods. Respiratory variables failed to reveal any significant differences between the treatments and baseline, or between the two different treatment regimens. The two treatment regimens achieved similar reductions in blood pressure. The prevalence of SAH was 25% before treatment, which is comparable to a prevalence of 20% in a similar group drawn from the same population but receiving various antihypertensive medications. The findings of this study are in agreement with previous reports using other classes of antihypertensive drugs that also failed to detect any tendency for increases in nocturnal respiratory disturbance indices over assessment periods of 8 weeks or shorter.
authors.affiliation: Department of Neurology, University of Pretoria and HF Verwoerd Hospital, South Africa.
authors.forename: P R
authors.initials: PR
authors.lastname: Bartel
authors.forename: M
authors.initials: M
authors.lastname: Loock
authors.forename: P
authors.initials: P
authors.lastname: Becker
authors.forename: E
authors.initials: E
authors.lastname: Robinson
authors.forename: C
authors.initials: C
authors.lastname: van der Meyden
authors.forename: S
authors.initials: S
authors.lastname: Rossouw
mesh_terms: D017311:Amlodipine / Q000009:adverse effects / Q000627:therapeutic use*; D000959:Antihypertensive Agents / Q000009:adverse effects / Q000627:therapeutic use*; D018592:Cross-Over Studies; D004311:Double-Blind Method; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D008750:Methyldopa / Q000009:adverse effects / Q000627:therapeutic use*; D012891:Sleep Apnea Syndromes / Q000209:etiology* / Q000503:physiopathology
chemical_list: D000959:Antihypertensive Agents; D017311:Amlodipine; D008750:Methyldopa