title: The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI.
abstract: The nucleotide sequence of the 948,061 base pairs of chromosome XVI has been determined, completing the sequence of the yeast genome. Chromosome XVI was the last yeast chromosome identified, and some of the genes mapped early to it, such as GAL4, PEP4 and RAD1 (ref. 2) have played important roles in the development of yeast biology. The architecture of this final chromosome seems to be typical of the large yeast chromosomes, and shows large duplications with other yeast chromosomes. Chromosome XVI contains 487 potential protein-encoding genes, 17 tRNA genes and two small nuclear RNA genes; 27% of the genes have significant similarities to human gene products, and 48% are new and of unknown biological function. Systematic efforts to explore gene function have begun.
authors.affiliation: Department of Biology, McGill University, Montreal, Canada. hbussey@monod.biol.mcgill.ca
authors.forename: H
authors.initials: H
authors.lastname: Bussey
authors.forename: R K
authors.initials: RK
authors.lastname: Storms
authors.forename: A
authors.initials: A
authors.lastname: Ahmed
authors.forename: K
authors.initials: K
authors.lastname: Albermann
authors.forename: E
authors.initials: E
authors.lastname: Allen
authors.forename: W
authors.initials: W
authors.lastname: Ansorge
authors.forename: R
authors.initials: R
authors.lastname: Araujo
authors.forename: A
authors.initials: A
authors.lastname: Aparicio
authors.forename: B
authors.initials: B
authors.lastname: Barrell
authors.forename: K
authors.initials: K
authors.lastname: Badcock
authors.forename: V
authors.initials: V
authors.lastname: Benes
authors.forename: D
authors.initials: D
authors.lastname: Botstein
authors.forename: S
authors.initials: S
authors.lastname: Bowman
authors.forename: M
authors.initials: M
authors.lastname: Brückner
authors.forename: J
authors.initials: J
authors.lastname: Carpenter
authors.forename: J M
authors.initials: JM
authors.lastname: Cherry
authors.forename: E
authors.initials: E
authors.lastname: Chung
authors.forename: C
authors.initials: C
authors.lastname: Churcher
authors.forename: F
authors.initials: F
authors.lastname: Coster
authors.forename: K
authors.initials: K
authors.lastname: Davis
authors.forename: R W
authors.initials: RW
authors.lastname: Davis
authors.forename: F S
authors.initials: FS
authors.lastname: Dietrich
authors.forename: H
authors.initials: H
authors.lastname: Delius
authors.forename: T
authors.initials: T
authors.lastname: DiPaolo
authors.forename: J
authors.initials: J
authors.lastname: Hani
mesh_terms: D001483:Base Sequence; D015825:Chromosomes, Fungal; D004271:DNA, Fungal; D005656:Fungal Proteins / Q000235:genetics; D006801:Humans; D016366:Open Reading Frames; D012441:Saccharomyces cerevisiae / Q000235:genetics*
chemical_list: D004271:DNA, Fungal; D005656:Fungal Proteins