title: Appropriate management of atypical ductal hyperplasia diagnosed by stereotactic core needle breast biopsy.
abstract: BACKGROUND
  Stereotactic core needle breast biopsy (SCNBB) is a minimally invasive technique used to sample nonpalpable mammographic abnormalities. The optimal management of atypical ductal hyperplasia (ADH) diagnosed by SCNBB is unknown. We hypothesized that ADH diagnosed by SCNBB should be evaluated by excisional breast biopsy (EBB) because of the risk of identifying carcinoma in association with ADH that would be missed if a diagnostic sampling technique alone was utilized.
  
  
  METHODS
  To test this hypothesis, a prospective diagnostic protocol was created which called for SCNBB instead of EBB for patients with mammographic abnormalities considered suspicious for malignancy. If ADH was noted on histologic evaluation of the cores, patients were advised to undergo an EBB.
  
  
  RESULTS
  A review of the initial 900 patients evaluated by SCNBB yielded 39 patients (4.3%) with ADH detected by SCNBB. Thirty-six of these 39 patients agreed to proceed with EBB: 19 patients demonstrated benign findings including atypical ductal hyperplasia, 13 patients demonstrated noninvasive ductal carcinoma, and 4 patients had evidence of invasive carcinoma.
  
  
  CONCLUSIONS
  A 47% rate of detecting noninvasive or invasive breast carcinoma supports the hypothesis that ADH detected by a sampling technique, such as SCNBB, should be managed by EBB.
authors.affiliation: Department of Surgery, Ochsner Clinic, New Orleans, LA 70121, USA.
authors.forename: D E
authors.initials: DE
authors.lastname: Gadzala
authors.forename: G J
authors.initials: GJ
authors.lastname: Cederbom
authors.forename: J S
authors.initials: JS
authors.lastname: Bolton
authors.forename: W M
authors.initials: WM
authors.lastname: McKinnon
authors.forename: G H
authors.initials: GH
authors.lastname: Farr
authors.forename: J
authors.initials: J
authors.lastname: Champaign
authors.forename: K
authors.initials: K
authors.lastname: Ordoyne
authors.forename: K
authors.initials: K
authors.lastname: Chung
authors.forename: G M
authors.initials: GM
authors.lastname: Fuhrman
mesh_terms: D001707:Biopsy, Needle / Q000379:methods*; D001940:Breast / Q000473:pathology; D001943:Breast Neoplasms / Q000473:pathology*; D018270:Carcinoma, Ductal, Breast / Q000473:pathology*; D005260:Female; D006801:Humans; D006965:Hyperplasia; D011446:Prospective Studies; D013238:Stereotaxic Techniques