title: Interleukin-6 production by human monocytes stimulated with Cryptococcus neoformans components.
abstract: In order to ascertain if Cryptococcus neoformans components can induce interleukin-6 (IL-6) production, we stimulated human whole blood with purified capsular products. Their potencies in stimulating IL-6 release were mannoproteins > galactoxylomannan = glucuronoxylomannan > alpha(1-3)glucan. IL-6 production was tumor necrosis factor alpha independent and required the presence of monocytes and plasma. Since IL-6 can stimulate replication of the human immunodeficiency virus in monocytic cells, these findings may be clinically relevant.
authors.affiliation: Istituto di Microbiologia, Facoltà di Medicina e Chirurgia, Università degli Studi di Messina, Italy.
authors.forename: D
authors.initials: D
authors.lastname: Delfino
authors.forename: L
authors.initials: L
authors.lastname: Cianci
authors.forename: E
authors.initials: E
authors.lastname: Lupis
authors.forename: A
authors.initials: A
authors.lastname: Celeste
authors.forename: M L
authors.initials: ML
authors.lastname: Petrelli
authors.forename: F
authors.initials: F
authors.lastname: Curró
authors.forename: V
authors.initials: V
authors.lastname: Cusumano
authors.forename: G
authors.initials: G
authors.lastname: Teti
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000378:metabolism; D003455:Cryptococcus neoformans / Q000502:physiology*; D006801:Humans; D015850:Interleukin-6 / Q000096:biosynthesis*; D008562:Membrane Glycoproteins / Q000494:pharmacology; D009000:Monocytes / Q000378:metabolism*; D011134:Polysaccharides / Q000494:pharmacology; D011135:Polysaccharides, Bacterial / Q000494:pharmacology; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology
chemical_list: D015850:Interleukin-6; D008562:Membrane Glycoproteins; D011134:Polysaccharides; D011135:Polysaccharides, Bacterial; D014409:Tumor Necrosis Factor-alpha; C025363:mannoproteins; C043689:galactoxylomannan; C027478:glucuronoxylomannan