The role of the collagenous and elastic system fibers in modulating bronchoconstriction.
The distribution and conformational changes of the fibers of the collagenous and elastic systems in guinea pig airways after a contractile agonist challenge are described. We observed a distinct pattern of behavior within the mucosal fibers during bronchoconstriction. Part of the fibers of the two systems tend to follow the epithelial invaginations towards the airway lumen, while the remaining ones seem to be attached to the internal smooth muscle. These layers of fibers in the mucosa are interconnected to one another and to the adventitial network by slender fibers. We suggest that the configuration and behavior of these fibers during bronchoconstriction may contribute to airway reopening after the contractile stimulus has ceased. The possible role of this mechanism in the pathophysiology of human asthma is discussed.
Mauad
T
T
Departamento de Patologia, Faculdade de Medicina, Universidade de São Paulo, Brasil.
Leick-Maldonado
F A
FA
Lemos
M
M
Dolhnikoff
M
M
Caldini
E C
EC
Montes
G S
GS
Saldiva
P H
PH
D000818:Animals; D016084:Bronchoconstriction / Q000502:physiology*; D003094:Collagen / Q000502:physiology*; D004547:Elastic Tissue / Q000502:physiology*; D004549:Elastin / Q000502:physiology*; D006168:Guinea Pigs
D003094:Collagen; D004549:Elastin