title: Cholera and myocarditis--a case report.
abstract: The authors describe the case of a fifty-nine-year-old white man, previously in good health, who initiated his present illness with acute episode of enterocolitis characterized by mild fever and, in the next eight hours, twenty-four episodes of watery diarrhea, nausea and vomiting, as well as generalized sweating and severe weakness secondary to hypovolemia and electrolyte disorder. These complications were corrected in seventy-two hours in the intensive care unit. Two days later, when the patient was stable hemodynamically, under cardiac monitoring and with normal laboratory studies including serum electrolytes, he developed electrocardiographic changes characterized by trifascicular block (prolonged P-R interval, complete right bundle branch block [CRBBB] and left posterior hemiblock [LPH]) with a cardiac rate of thirty beats per minute, for which a temporary pacemaker was inserted. Endomyocardial biopsy showed histopathologic signs of myocarditis and the immunologic study of the cardiac tissue revealed positive polymerize chain reaction (PCR+) with the presence of antitoxine choleric antibodies (AcTCA). After three weeks, the same conduction disturbances remained, for which a permanent pacemaker was inserted. On top of intravenous fluid replacement and electrolyte supplements, the patient was managed with tetracycline 2 g a day for one week and sulfamethoxazole-trimethoprim 800/160 mg a day for two weeks. The purpose of this study is to present a rare and very well-documented myocarditis by cholera in a patient with enteric disease, in whom several cardiac complications occurred.
authors.affiliation: Hospital de Especialidades, Centro Medico la Raza, Instituto Mexicano del Seguro Social, D.F.
authors.forename: F
authors.initials: F
authors.lastname: Leon
authors.forename: E
authors.initials: E
authors.lastname: Badui
authors.forename: A
authors.initials: A
authors.lastname: Campos
authors.forename: R
authors.initials: R
authors.lastname: Enciso
authors.forename: T
authors.initials: T
authors.lastname: Fakih
authors.forename: M
authors.initials: M
authors.lastname: Guadarrama
authors.forename: A
authors.initials: A
authors.lastname: Valdespino
authors.forename: H
authors.initials: H
authors.lastname: Murillo
authors.forename: C
authors.initials: C
authors.lastname: Calleja
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000907:Antibodies, Bacterial / Q000032:analysis; D001919:Bradycardia / Q000209:etiology; D002037:Bundle-Branch Block / Q000209:etiology; D002771:Cholera / Q000150:complications* / Q000188:drug therapy / Q000503:physiopathology; D003967:Diarrhea / Q000503:physiopathology; D004562:Electrocardiography; D004760:Enterocolitis / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009205:Myocarditis / Q000188:drug therapy / Q000209:etiology*; D009325:Nausea / Q000503:physiopathology; D010138:Pacemaker, Artificial; D016133:Polymerase Chain Reaction; D013546:Sweating / Q000502:physiology; D013752:Tetracycline / Q000627:therapeutic use; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000627:therapeutic use; D014734:Vibrio cholerae / Q000235:genetics / Q000276:immunology; D014839:Vomiting / Q000503:physiopathology
chemical_list: D000900:Anti-Bacterial Agents; D000907:Antibodies, Bacterial; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D013752:Tetracycline