[The diverse effects of the combined action of cadmium chloride and ionizing radiation on the content of metallothioneins in mouse bone marrow and liver].
It was shown that introduction of cadmium chloride (0.75 mg/kg Cd2+) in combination with gamma irradiation (8.5 Gy) of mice increases the level of metallothioneines (MTs) in the bone marrow and liver of mice. The maximum effect was observed in 24-30 h after the performance. Similarly, irradiation with the doses of 3 to 10 Gy resulted in an increase in the contents of both MT isoforms (MT1 and MT2) in the bone marrow in 24 h. A combined action of gamma irradiation and a heavy metal caused an additive effect on the MT content in the bone marrow, whereas the MT content in liver was 2 times lower than that predicted theoretically. A possible mechanism of the discovered phenomenon was discussed. Supposedly, it is associated with different degrees of the radiation-induced inhibition of the MT1 and MT2 expression by cadmium ions.
Koterov
A N
AN
Trebenok
Z A
ZA
Pushkareva
N B
NB
Nikol'skiĭ
A V
AV
D000818:Animals; D001853:Bone Marrow / Q000737:chemistry / Q000187:drug effects* / Q000528:radiation effects*; D001854:Bone Marrow Cells; D019256:Cadmium Chloride / Q000494:pharmacology*; D002273:Carcinogens / Q000494:pharmacology*; D004307:Dose-Response Relationship, Radiation; D005720:Gamma Rays; D008099:Liver / Q000737:chemistry / Q000187:drug effects* / Q000528:radiation effects*; D008297:Male; D008668:Metallothionein / Q000032:analysis / Q000187:drug effects* / Q000528:radiation effects*; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D011836:Radiation Tolerance / Q000187:drug effects; D013997:Time Factors
D002273:Carcinogens; D008668:Metallothionein; D019256:Cadmium Chloride