title: Effects of inhaled albuterol and ipratropium bromide on autonomic control of the cardiovascular system.
abstract: OBJECTIVE
  Systemic administration of beta-agonist and anticholinergic drugs markedly impair normal autonomic heart rate control. The purpose of this study was to quantify and compare the effects of therapeutic doses of inhaled albuterol and ipratropium on autonomic control of the cardiovascular system.
  
  
  METHODS
  Randomized, double-blind, placebo-controlled, crossover design study.
  
  
  METHODS
  Tertiary-care hospital.
  
  
  METHODS
  Twelve healthy male volunteers.
  
  
  METHODS
  Subjects self-administered four puffs through a spacer device from one of three identical inhalers containing albuterol (100 microg per puff), ipratropium (20 microg per puff), or placebo in three different testing sessions.
  
  
  METHODS
  ECG and noninvasive continuous BP traces were recorded at baseline and from 45 to 75 min after administration of the drug. Autonomic control of the cardiovascular system was quantified by analysis of spontaneous baroreflex sensitivity and power spectral analysis of heart rate variability.
  
  
  RESULTS
  Neither albuterol nor ipratropium caused a significant alteration in baroreflex sensitivity, normalized low-power frequency, or normalized high-power frequency. No adverse effects were reported by subjects.
  
  
  CONCLUSIONS
  Inhalation of four puffs of albuterol (400 microg) or ipratropium (80 microg) does not alter the autonomic control of the cardiovascular system in young, healthy male subjects.
authors.affiliation: Department of Anaesthesia, Queen's University, Kingston, Ontario, Canada.
authors.forename: A J
authors.initials: AJ
authors.lastname: Dagnone
authors.forename: J L
authors.initials: JL
authors.lastname: Parlow
mesh_terms: D000280:Administration, Inhalation; D000293:Adolescent; D000328:Adult; D000420:Albuterol / Q000008:administration & dosage* / Q000009:adverse effects / Q000494:pharmacology; D001341:Autonomic Nervous System / Q000187:drug effects* / Q000502:physiology; D001993:Bronchodilator Agents / Q000008:administration & dosage* / Q000009:adverse effects / Q000494:pharmacology; D002320:Cardiovascular Physiological Phenomena; D002319:Cardiovascular System / Q000187:drug effects* / Q000294:innervation; D018592:Cross-Over Studies; D004311:Double-Blind Method; D006801:Humans; D009241:Ipratropium / Q000008:administration & dosage* / Q000009:adverse effects / Q000494:pharmacology; D008297:Male; D009330:Nebulizers and Vaporizers; D012016:Reference Values
chemical_list: D001993:Bronchodilator Agents; D009241:Ipratropium; D000420:Albuterol