[Morphology of myocardial adaptive responses to extreme environmental factors].
The paper deals with myocardial spatial reorganization under the influence of emergency environmental factors: low systemic temperature (-7 degrees C), single overheating (at 43 degrees C), long-term stay in the high mountains (3200 m above sea level) and after transportation to high latitudes (at 69 of the North). Among the changes in the ratio of major myocardial tissue components, 2 stages are identified: 1) that is characterized by profound changes in the volume and surface-to-volume ratios of major tissue components (capillaries and cardiomyocytes in particular); 2) that shows a tendency to normalization of tissue architectonics. These changes in tissue reorganization is likely to be caused by stress responses and to reflect some structural mechanisms of a nonspecific response to emergency. In contrast, the intracellular spatial reorganization of cardiomyocytes is characterized by persistently recorded disproportional changes in the volume ratios of bulk organelles (mitochondrias and myofibrills in particular). The differences found in the changes of tissue and intracellular spatial reorganization reflect the basic features of spatial-and-temporal organization of regenerative processes in the parenchymal cells (cardiomyocytes) and stromal components.
Nepomniashchkh
L M
LM
NII of Regional Pathology and Pathomorphology SO RAMN, Novosibirsk.
D000222:Adaptation, Physiological; D000531:Altitude; D000818:Animals; D003080:Cold Temperature / Q000009:adverse effects; D004781:Environmental Exposure / Q000009:adverse effects*; D006358:Hot Temperature / Q000009:adverse effects; D006801:Humans; D009206:Myocardium / Q000166:cytology*; D013312:Stress, Physiological