Toxicity of monomers HEMA, DEGMA and AEMA, used in synthesis of hydrogels for medical applications.
Acute toxicity parameters (lethal doses) were evaluated and calculated after i.m. and i.p. administration of 2-hydroxyethyl methacrylate (HEMA), 2-(hydroxyethoxy)ethyl methacrylate (DEGMA) and 2-(acetoxy)ethyl methacrylate (AEMA) to rats. Our previous findings were revisited and corrected. Based on preceding standardization and physiological values study, some clinical chemical and hematological markers of in vivo subacute i.m. toxicity were followed. Hematological parameters revealed to be of low sensitivity to the toxic influence. Clinical chemical tests suggest the prevalent muscle cell injury.
Schneiderka
P
P
Department of Clinical Biochemistry, First Faculty of Medicine, Charles University, Prague, Czech Republic.
Roosová
M
M
Jojková
K
K
Prokes
J
J
Labský
J
J
Vacík
J
J
D000818:Animals; D005260:Female; D007928:Lethal Dose 50; D008689:Methacrylates / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar
D008689:Methacrylates