[A method for selecting drugs that affect the rheological properties of the blood in vitro].
For the selection of compounds affecting the hemorrheologic status a method for reproducing disorders of blood rheologic properties in vitro was developed. It consists in 60-min incubation of blood at 42 degrees C. The hemorrheologic effect of quercetin under such conditions was studied and a dependence of the effect of quercetin on blood viscosity and red cell aggregation on the drug concentration was revealed.
Plotnikov
M B
MB
Koltunov
A A
AA
Aliev
O I
OI
D000818:Animals; D001809:Blood Viscosity / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004903:Erythrocyte Aggregation / Q000187:drug effects; D018056:Hemorheology / Q000187:drug effects*; D066298:In Vitro Techniques; D008722:Methods; D011794:Quercetin / Q000494:pharmacology; D051381:Rats; D013696:Temperature; D013997:Time Factors
D011794:Quercetin