Not just another pretty face: regulation of platelet function at the cytoplasmic face of integrin alpha IIb beta 3.
Integrin alpha IIb beta 3 is necessary for platelet thrombus formation by virtue of its ability to bind fibrinogen and von Willebrand factor in a regulated fashion and to mediate platelet aggregation. Moreover, alpha IIb beta 3 transduces inward signals in response to ligand binding which promote cytoskeletal reorganization and other post-ligand binding events. Anchorage and signaling through alpha IIb beta 3 appear to be controlled by interactions of intracellular proteins with the cytoplasmic tails of alpha IIb and/or beta 3. The cytoplasmic tails and associated cytoskeletal components may function as a scaffold or nucleation site for the assembly of enzymes, substrates and adaptor molecules into a signaling complex. Identification of the components of this signaling complex and characterization of their dynamic interactions should lead to insights into the molecular basis of platelet activation defects and may provide a rationale for the development of new anti-thrombotic drugs.
Shattil
S J
SJ
Department of Vascular Biology, Scripps Research Institute, La Jolla, CA 92037, USA. shattil@scripps.edu
Gao
J
J
Kashiwagi
H
H
D001792:Blood Platelets / Q000502:physiology*; D003593:Cytoplasm / Q000502:physiology*; D003599:Cytoskeleton / Q000502:physiology*; D006801:Humans; D008024:Ligands; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000502:physiology*; D011485:Protein Binding; D015398:Signal Transduction / Q000502:physiology*
D008024:Ligands; D019039:Platelet Glycoprotein GPIIb-IIIa Complex