title: Squamous cell carcinoma in perineal inflammatory disease.
abstract: Four patients with squamous cell carcinoma of the perineal region were diagnosed and treated during the last 4 years in our institutions. The underlying diagnoses consisted of recurrent pilonidal disease, Crohn's disease, and hidradenitis suppurativa. In all patients, a pattern of a long-term inflammatory process was evident. Current concepts regarding the pathophysiology of a chronic inflammatory state and malignant transformation are reviewed. We conclude that regardless of the original pathology, all chronic inflammatory processes in the perineal region should be evaluated for malignant degeneration. A high index of suspicion may potentiate an early diagnosis, possibly improving the chance of cure.
authors.affiliation: Division of Plastic Surgery, Toronto Hospital, University of Toronto, Ontario, Canada.
authors.forename: E
authors.initials: E
authors.lastname: Gur
authors.forename: P C
authors.initials: PC
authors.lastname: Neligan
authors.forename: R
authors.initials: R
authors.lastname: Shafir
authors.forename: R
authors.initials: R
authors.lastname: Reznick
authors.forename: M
authors.initials: M
authors.lastname: Cohen
authors.forename: T
authors.initials: T
authors.lastname: Shpitzer
mesh_terms: D000038:Abscess / Q000473:pathology / Q000601:surgery*; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000601:surgery*; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010502:Perineum / Q000473:pathology / Q000601:surgery*; D010864:Pilonidal Sinus / Q000473:pathology / Q000601:surgery*; D012086:Reoperation; D012867:Skin / Q000473:pathology; D012874:Skin Diseases, Infectious / Q000473:pathology / Q000601:surgery*; D012878:Skin Neoplasms / Q000473:pathology / Q000601:surgery*