title: Association of family history of cervical, ovarian, and uterine cancer with histological categories of lung cancer: the Iowa Women's Health Study.
abstract: A family history of cervical, ovarian, or uterine cancer has been shown to be associated with increased lung cancer risk among postmenopausal women. The present report examines the hypotheses that a family history of cervical cancer is positively associated with histological subtypes of lung cancer most strongly associated with smoking and that a family history of ovarian or uterine cancer are positively associated with risk of adenocarcinoma of the lung. Data are from the Iowa Women's Health Study, a prospective cohort study of 34,480 women ages 55-69 in 1986. Personal smoking histories, use of alcohol, and family history of selected cancers in first- and second-degree relatives were collected at baseline. Follow-up for cancer occurrence was achieved through the State Health Registry of Iowa. After baseline exclusions, a total of 343 incident lung cancers were identified in the cohort at risk through 1994. Women with a family history of cervical cancer in a first-degree relative had a multivariate-adjusted relative risk of lung cancer of 1.6 [95% confidence interval (CI): 0.98-2.6] compared to women without a family history. The risk was particularly high for malignancies most strongly associated with smoking (squamous, small cell, and large cell tumors; relative risk, 2.0; 95% CI, 1.1-3.7). Consistent with our hypotheses, a family history of ovarian cancer was associated with an approximately 2-fold increased risk (multivariate adjusted) of adenocarcinoma of the lung; the association with malignancies more strongly associated with smoking was inverse (relative risk, 0.6; 95% CI, 0.2-2.4). A family history of uterine cancer was not associated with adenocarcinoma, but there was a positive association observed for the most strongly smoking-associated histological types. These results suggest that a family history of cervical cancer is a modest independent risk factor for lung cancers most strongly associated with smoking, and a family history of ovarian cancer is a risk factor for adenocarcinoma of the lung.
authors.affiliation: Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, USA. anderson_k@epivax.epi.umn.edu
authors.forename: K E
authors.initials: KE
authors.lastname: Anderson
authors.forename: C
authors.initials: C
authors.lastname: Woo
authors.forename: J E
authors.initials: JE
authors.lastname: Olson
authors.forename: T A
authors.initials: TA
authors.lastname: Sellers
authors.forename: W
authors.initials: W
authors.lastname: Zheng
authors.forename: L H
authors.initials: LH
authors.lastname: Kushi
authors.forename: A R
authors.initials: AR
authors.lastname: Folsom
mesh_terms: D000230:Adenocarcinoma / Q000209:etiology* / Q000473:pathology; D000368:Aged; D000437:Alcoholism / Q000150:complications; D005260:Female; D006801:Humans; D007484:Iowa; D008175:Lung Neoplasms / Q000209:etiology* / Q000473:pathology; D008875:Middle Aged; D015999:Multivariate Analysis; D010051:Ovarian Neoplasms / Q000235:genetics*; D017698:Postmenopause; D011446:Prospective Studies; D012306:Risk; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects*; D002583:Uterine Cervical Neoplasms / Q000235:genetics*; D014594:Uterine Neoplasms / Q000235:genetics*