title: Propofol sedation during awake craniotomy for seizures: patient-controlled administration versus neurolept analgesia.
abstract: This prospective study evaluated the safety and efficacy of patient-controlled sedation (PCS) using propofol during awake seizure surgery performed under bupivacaine scalp blocks. Thirty-seven patients were randomized to receive either propofol PCS combined with a basal infusion of propofol (n = 20) or neurolept analgesia using an initial bolus dose of fentanyl and droperidol followed by a fentanyl infusion (n = 17). Both groups received supplemental fentanyl and dimenhydrinate for intraoperative pain and nausea, respectively. Comparisons were made between groups for sedation, memory, and cognitive function, patient satisfaction, and incidence of complications. Levels of intraoperative sedation and patient satisfaction were similar between groups. Memory and cognitive function were well preserved in both groups. The incidence of transient episodes of ventilatory rate depression (<8 bpm) was more frequent among the propofol patients (5 vs 0, P = 0.04), particularly after supplemental doses of opioid. Intraoperative seizures were more common among the neurolept patients (7 vs 0, P = 0.002). PCS using propofol represents an effective alternative to neurolept analgesia during awake seizure surgery performed in a monitored care environment.
authors.affiliation: Department of Anaesthesia, London Health Sciences Centre, University of Western Ontario, Canada.
authors.forename: I A
authors.initials: IA
authors.lastname: Herrick
authors.forename: R A
authors.initials: RA
authors.lastname: Craen
authors.forename: A W
authors.initials: AW
authors.lastname: Gelb
authors.forename: L A
authors.initials: LA
authors.lastname: Miller
authors.forename: C S
authors.initials: CS
authors.lastname: Kubu
authors.forename: J P
authors.initials: JP
authors.lastname: Girvin
authors.forename: A G
authors.initials: AG
authors.lastname: Parrent
authors.forename: M
authors.initials: M
authors.lastname: Eliasziw
authors.forename: J
authors.initials: J
authors.lastname: Kirkby
mesh_terms: D000759:Adjuvants, Anesthesia; D000328:Adult; D016058:Analgesia, Patient-Controlled / Q000379:methods*; D000701:Analgesics, Opioid; D000927:Anticonvulsants / Q000627:therapeutic use; D014150:Antipsychotic Agents; D002045:Bupivacaine; D016292:Procedural Sedation; D003399:Craniotomy / Q000379:methods*; D004329:Droperidol; D004569:Electroencephalography / Q000379:methods; D005260:Female; D005283:Fentanyl; D006801:Humans; D006993:Hypnotics and Sedatives; D008297:Male; D008875:Middle Aged; D016343:Monitoring, Intraoperative / Q000379:methods; D009407:Nerve Block; D015742:Propofol; D011446:Prospective Studies; D012640:Seizures / Q000601:surgery*
chemical_list: D000759:Adjuvants, Anesthesia; D000701:Analgesics, Opioid; D000927:Anticonvulsants; D014150:Antipsychotic Agents; D006993:Hypnotics and Sedatives; D004329:Droperidol; D005283:Fentanyl; D002045:Bupivacaine; D015742:Propofol