Ontogeny of neurotransmitter amino acids in human fetal brains.
A wide spectrum of developmental profiles is presented for a few important neurotransmitter amino acids, namely gamma-aminobutyric acid, glycine, glutamic acid, aspartic acid and taurine as well as the key enzymes involved in their metabolism in human fetal brains of different gestational ages. Besides taurine almost all these amino acids and their key metabolic enzymes were found to be progressively enhanced upto the mid period of third trimester of pregnancy indicating a rapid growth of nerve processes, myelination and maturation of fetal brains particularly during this period. Interestingly taurine showed an inverse relationship of ontogenic pattern with respect to its biosynthesizing enzyme in fetal brains.
Das
S K
SK
Department of Biochemistry and Biophysics, University of Kalyani, West Bengal, India.
Ray
P K
PK
D000612:4-Aminobutyrate Transaminase / Q000378:metabolism; D000445:Aldehyde Oxidoreductases / Q000378:metabolism; D000596:Amino Acids / Q000378:metabolism*; D001224:Aspartic Acid / Q000378:metabolism; D001921:Brain / Q000196:embryology* / Q000378:metabolism*; D005260:Female; D005865:Gestational Age; D018698:Glutamic Acid / Q000378:metabolism; D005998:Glycine / Q000378:metabolism; D012696:Glycine Hydroxymethyltransferase / Q000378:metabolism; D006801:Humans; D018377:Neurotransmitter Agents / Q000378:metabolism*; D011247:Pregnancy; D050644:Succinate-Semialdehyde Dehydrogenase; D013654:Taurine / Q000378:metabolism; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D000596:Amino Acids; D018377:Neurotransmitter Agents; D013654:Taurine; D001224:Aspartic Acid; D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid; D000445:Aldehyde Oxidoreductases; C493643:ALDH5A1 protein, human; D050644:Succinate-Semialdehyde Dehydrogenase; D012696:Glycine Hydroxymethyltransferase; D000612:4-Aminobutyrate Transaminase; D005998:Glycine