[Quantitative patterns in the yield of chromosome aberrations in a human lymphocyte culture with fractionated gamma-neutron irradiation at different stages of the mitotic cycle. The cytogenetic effects at stage G1].
Quantitative regularities of the chromosome aberrations yield in the human lymphocyte culture affected by fractionated gamma/neutron irradiation (in the direct and inverse sequences) at a stage of the presynthesis (G1), with the 1 to 5 h intervals between the dose fractions, were studied. The obtained results were compared with those for the stage G0 described in the previous paper. The cytogenetic effect, with doses and intervals between the dose fractions being equal, depended significantly on a stage of the mitotic cycle of the cells. The effect was opposite for the stages G0 and G1: super- and subadditive, respectively.
Pozdyshkina
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D002478:Cells, Cultured; D002869:Chromosome Aberrations; D004307:Dose-Response Relationship, Radiation; D005214:Fast Neutrons; D016193:G1 Phase / Q000528:radiation effects*; D005720:Gamma Rays; D006801:Humans; D008214:Lymphocytes / Q000528:radiation effects* / Q000648:ultrastructure; D008938:Mitosis / Q000528:radiation effects*; D013997:Time Factors