The effect of dexamethasone on resistance of older lambs to infection with Nematodirus battus.
Old lambs (8 months of age) infected with 50,000 L3 of Nematodirus battus had larvae developing normally in their tissues on day 4 post-infection (P.I.), but by day 8 P.I. there were only 4105 +/- 1044 worms left in the alimentary tract. Some of these worms contained crystals in their intestine. Eight-month-old lambs treated with dexamethasone and infected with 50,000 L3 of N. battus contained a mean worm burden of 7878 +/- 1262 on 18 days P.I. Untreated 8-month-old lambs similarly infected were virtually worm free by day 18 P.I. Peripheral eosinophilia became elevated in the untreated lambs over the course of infection and, at post-mortem, the tissue mast cell and eosinophil counts were much higher than in the dexamethasone treated group. Although the phenomenon of age resistance is thought to have a strong immunological component, there may also be other physiological factors, resulting in fewer nematodes and lower fecundity of the worms.
Winter
M D
MD
Department of Biology, University of Leeds, UK.
Wright
C
C
Lee
D L
DL
D000375:Aging / Q000276:immunology*; D000818:Animals; D000909:Antibodies, Helminth / Q000096:biosynthesis; D002452:Cell Count; D003907:Dexamethasone / Q000494:pharmacology*; D004804:Eosinophils / Q000276:immunology; D005938:Glucocorticoids / Q000494:pharmacology*; D007411:Intestinal Diseases, Parasitic / Q000276:immunology / Q000469:parasitology; D008407:Mast Cells / Q000276:immunology; D009348:Nematoda / Q000502:physiology; D009349:Nematode Infections / Q000276:immunology*; D012756:Sheep; D012757:Sheep Diseases / Q000276:immunology* / Q000469:parasitology*; D013997:Time Factors
D000909:Antibodies, Helminth; D005938:Glucocorticoids; D003907:Dexamethasone