title: The carboxyl-terminal sequence of rat intestinal mucin RMuc3 contains a putative transmembrane region and two EGF-like motifs.
abstract: A 3' RACE technique was used to establish the nucleotide sequence encoding the C-terminal 379 amino acids of rat intestinal Muc3. Unlike the C-terminus of Muc2 and many secretory mucins, Muc3 contains two EGF motifs and a putative transmembrane domain. The mRNA for rat Muc3 is 7.5-8.0 kb.
authors.affiliation: Division of Research Biochemistry, Research Institute, The Hospital for Sick Children and the University of Toronto, Canada.
authors.forename: I A
authors.initials: IA
authors.lastname: Khatri
authors.forename: G G
authors.initials: GG
authors.lastname: Forstner
authors.forename: J F
authors.initials: JF
authors.lastname: Forstner
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002462:Cell Membrane / Q000378:metabolism*; D003001:Cloning, Molecular; D018076:DNA, Complementary / Q000235:genetics; D004815:Epidermal Growth Factor / Q000235:genetics; D007421:Intestine, Small / Q000378:metabolism*; D008969:Molecular Sequence Data; D055263:Mucin-3; D009077:Mucins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D009363:Neoplasm Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D012333:RNA, Messenger / Q000235:genetics; D051381:Rats
chemical_list: D018076:DNA, Complementary; C524651:Muc3 protein, rat; D055263:Mucin-3; D009077:Mucins; D009363:Neoplasm Proteins; D012333:RNA, Messenger; D004815:Epidermal Growth Factor