title: General principles of wound healing.
abstract: Wound healing is a complex process involving different biologic and immunologic systems. Despite improvements in diagnostics and therapy, wound failures remain a clinical problem. The approach to a nonhealed wound is an interdisciplinary challenge that should not be underestimated. Better understanding of the complex wound-healing cascade helps our approach to wound healing and its possible failure. Manipulations of the involved immunologic features offer future therapeutic strategies.
authors.affiliation: Department of Surgery, Sinai Hospital of Baltimore, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA.
authors.forename: M B
authors.initials: MB
authors.lastname: Witte
authors.forename: A
authors.initials: A
authors.lastname: Barbul
mesh_terms: D002455:Cell Division; D002633:Chemotaxis; D002921:Cicatrix / Q000503:physiopathology; D003094:Collagen / Q000378:metabolism; D016207:Cytokines / Q000032:analysis; D005109:Extracellular Matrix / Q000378:metabolism; D006487:Hemostasis / Q000502:physiology; D006801:Humans; D008262:Macrophage Activation; D014945:Wound Healing / Q000276:immunology / Q000502:physiology*
chemical_list: D016207:Cytokines; D003094:Collagen