Protease inhibitors and urolithiasis.
OBJECTIVE
We discuss the specific urological abnormalities associated with protease inhibitor therapy.


METHODS
We report on a human immunodeficiency virus positive patient who was on protease inhibitor therapy and presented with renal colic.


RESULTS
The stone passed spontaneously. Stone analysis was not consistent with any known composition of urinary calculus.


CONCLUSIONS
The positive effects of protease inhibitors in human immunodeficiency virus positive patients mandate that the urological community become familiar with these drugs and the specific urological complications as the use of these drugs becomes widespread.
Sutherland
S E
SE
Department of Urology, Case Western Reserve University, Cleveland, Ohio, USA.
Reigle
M D
MD
Seftel
A D
AD
Resnick
M I
MI
D000328:Adult; D017320:HIV Protease Inhibitors / Q000009:adverse effects*; D006679:HIV Seropositivity / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D019469:Indinavir / Q000009:adverse effects*; D008297:Male; D014545:Urinary Calculi / Q000139:chemically induced*
D017320:HIV Protease Inhibitors; D019469:Indinavir