title: Disruptive behavior and actigraphic measures in home-dwelling patients with Alzheimer's disease: preliminary report.
abstract: The purpose of this preliminary report was to explore overall level and diurnal patterning of caregiver reports of abnormal behavior and to explore relationships with actigraphic measures of sleep/wake activity in Alzheimer's disease (AD) patients. Our primary behavioral measure was the Time-based Behavioral Disturbance Questionnaire (TBDQ). The overall score on this measure was shown to have adequate test-retest reliability and convergent validity with another behavioral measure. Significant correlations were obtained between the TBDQ overall score and actigraphically scored sleep efficiency (r = -.35, P < .05) and wake after sleep onset (r = .43, P < .01) in 41 subjects. The data suggest a moderate relationship between actigraphic measures of sleep/wake and disturbed behavior in home-dwelling AD patients.
authors.affiliation: Department of Veterans Affairs Medical Center, California, USA.
authors.forename: L
authors.initials: L
authors.lastname: Friedman
authors.forename: H C
authors.initials: HC
authors.lastname: Kraemer
authors.forename: V
authors.initials: V
authors.lastname: Zarcone
authors.forename: S
authors.initials: S
authors.lastname: Sage
authors.forename: D
authors.initials: D
authors.lastname: Wicks
authors.forename: D L
authors.initials: DL
authors.lastname: Bliwise
authors.forename: J
authors.initials: J
authors.lastname: Sheikh
authors.forename: J
authors.initials: J
authors.lastname: Tinklenberg
authors.forename: J A
authors.initials: JA
authors.lastname: Yesavage
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000175:diagnosis* / Q000523:psychology; D017028:Caregivers / Q000523:psychology; D002940:Circadian Rhythm; D017281:Cost of Illness; D005260:Female; D006701:Home Nursing / Q000523:psychology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D011595:Psychomotor Agitation / Q000175:diagnosis* / Q000523:psychology; D012920:Social Behavior Disorders / Q000175:diagnosis* / Q000523:psychology