title: Disorders of hemostasis in childhood: risk factors for venous thromboembolism.
abstract: In both children and neonates with venous thrombosis, one or more predisposing risk factors can generally be identified. Underlying prothrombotic medical conditions are common in these patients. In addition, a "trigger factor" such as a catheter, surgery or trauma is usually present. However genetic and acquired coagulation abnormalities are also identified in children with venous thrombosis who are appropriately studied. A careful family history and assays for the LA, AT-III, protein C, protein S and the factor V Leiden mutation should be part of the evaluation of infants and children with venous thrombosis.
authors.affiliation: Department of Pediatrics, University of Colorado, Health Sciences Center, Denver, USA.
authors.forename: M J
authors.initials: MJ
authors.lastname: Manco-Johnson
mesh_terms: D000293:Adolescent; D002405:Catheterization, Central Venous / Q000009:adverse effects; D002648:Child; D002675:Child, Preschool; D002869:Chromosome Aberrations / Q000235:genetics; D025063:Chromosome Disorders; D002986:Clinical Trials as Topic; D005260:Female; D006487:Hemostasis / Q000502:physiology*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D011183:Postoperative Complications; D012307:Risk Factors; D013923:Thromboembolism / Q000453:epidemiology / Q000235:genetics / Q000503:physiopathology*; D013924:Thrombophlebitis / Q000453:epidemiology / Q000235:genetics / Q000503:physiopathology*