Ncx, a Hox11 related gene, is expressed in a variety of tissues derived from neural crest cells.
We have isolated the murine homeobox gene (Ncx) that belong to a Hox11 gene family. Expression of the Ncx gene was analyzed in total RNAs from embryos by reverse transcribed polymerase chain reaction (RT-PCR). The mRNA was detected in embryos after 9.5 days of embryogenesis (E9.5) and was maximal at E12.5. The RT-PCR also detected the message in total RNAs from adrenal glands and intestine in adult mice. The expression was further examined in various tissues from embryos by in situ hybridization. It was detected in dorsal root ganglia, cranial nerve ganglia (V, IX, X), enteric nerve ganglia and adrenal glands from embryos between E9.5 and E13.5. Since its expression is restricted to tissues derived from neural crest cells, Ncx may play a role in differentiation and proliferation of neural crest lineage cells.
Hatano
M
M
Division of Developmental Genetics, Chiba University School of Medicine, Japan.
Iitsuka
Y
Y
Yamamoto
H
H
Dezawa
M
M
Yusa
S
S
Kohno
Y
Y
Tokuhisa
T
T
D000311:Adrenal Glands / Q000378:metabolism; D000818:Animals; D001934:Branchial Region / Q000378:metabolism; D003391:Cranial Nerves / Q000378:metabolism; D005727:Ganglia, Spinal / Q000378:metabolism; D018398:Homeodomain Proteins / Q000235:genetics* / Q000378:metabolism; D017403:In Situ Hybridization; D007413:Intestinal Mucosa / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D009432:Neural Crest / Q000378:metabolism*; D015513:Oncogene Proteins / Q000235:genetics / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism; D013997:Time Factors; D001743:Urinary Bladder / Q000378:metabolism
D018398:Homeodomain Proteins; D015513:Oncogene Proteins; D012333:RNA, Messenger; C491534:TLX2 protein, human; C487378:Tlx1 protein, mouse; C107836:Tlx2 protein, mouse