A bioactive seco-rosane diterpenoid from Vellozia candida.
Bioassay-directed fractionation of the bioactive alcoholic extracts of Vellozia candida yielded a new 6,7-seco-rosane diterpenoid, candidalactone (1), which showed moderate toxicity toward DNA repair-deficient mutants of Saccharomyces cerevisiae. Another new but inactive rosane diterpenoid, candidenodiol (3), was also obtained.
Valente
L M
LM
Department of Chemistry, Virginia Polytechnic Institute and State University, Blacksburg 24061-0212, USA.
Gunatilaka
A A
AA
Kingston
D G
DG
Patitucci
M L
ML
Pinto
A C
AC
D016587:Antimutagenic Agents / Q000302:isolation & purification* / Q000494:pharmacology; D003374:Coumarins / Q000302:isolation & purification* / Q000494:pharmacology; D004260:DNA Repair; D004224:Diterpenes / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D010946:Plants, Medicinal / Q000737:chemistry*; D012441:Saccharomyces cerevisiae / Q000187:drug effects / Q000235:genetics; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
D016587:Antimutagenic Agents; D003374:Coumarins; D004224:Diterpenes; C106392:candidalactone