title: A paradoxical effect of bronchodilators.
abstract: Lactic acidosis previously has been reported during treatment of asthma with beta-2 agonists. However, this metabolic disturbance never had any clinical consequence. We report a case of a patient with asthma in whom beta-2 agonist administration increased dyspnea by metabolic acidosis due to a sharp increase in lactate levels (hyperlactatemia) and led to inappropriate intensification of bronchodilator therapy.
authors.affiliation: Intensive Care Unit, Hôpital Saint Antoine, Paris, France.
authors.forename: E
authors.initials: E
authors.lastname: Maury
authors.forename: V
authors.initials: V
authors.lastname: Ioos
authors.forename: B
authors.initials: B
authors.lastname: Lepecq
authors.forename: B
authors.initials: B
authors.lastname: Guidet
authors.forename: G
authors.initials: G
authors.lastname: Offenstadt
mesh_terms: D000140:Acidosis, Lactic / Q000139:chemically induced*; D000208:Acute Disease; D000318:Adrenergic beta-Agonists / Q000009:adverse effects*; D000420:Albuterol / Q000009:adverse effects*; D001249:Asthma / Q000150:complications / Q000188:drug therapy; D001993:Bronchodilator Agents / Q000009:adverse effects*; D004417:Dyspnea / Q000139:chemically induced; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D000318:Adrenergic beta-Agonists; D001993:Bronchodilator Agents; D000420:Albuterol