Association analysis of six candidate genes in a sample of Australian hypertensive patients.
1. Essential hypertension is characterized by increased vascular resistance due to narrowing of the small arterioles. This may be influenced by vasoactive substances, cell growth and vascular remodelling. 2. A sample of Australian hypertensive and normotensive subjects was investigated for association with genetic markers which are candidates for a role in blood pressure (BP) regulation due to potential effects on vascular diameter. 3. The six markers used were for genes encoding vasoconstrictors, growth factors and a structural protein of the extracellular matrix. 4. No significant association of any of the markers used was found with BP status in this sample of patients.
Huggard
P R
PR
Department of Medicine, University of Queensland, Prince Charles Hospital, Chermside, Australia.
Summers
K M
KM
West
J
J
West
M J
MJ
D000368:Aged; D000808:Angiotensinogen / Q000235:genetics; D001315:Australia / Q000453:epidemiology; D004198:Disease Susceptibility; D004549:Elastin / Q000235:genetics; D005260:Female; D005796:Genes; D006801:Humans; D006973:Hypertension / Q000453:epidemiology / Q000235:genetics*; D007610:Kallikreins / Q000235:genetics; D008297:Male; D008875:Middle Aged; D011972:Receptor, Insulin / Q000235:genetics; D011945:Receptors, Angiotensin / Q000235:genetics; D017451:Receptors, Somatomedin / Q000235:genetics
D011945:Receptors, Angiotensin; D017451:Receptors, Somatomedin; D000808:Angiotensinogen; D004549:Elastin; D011972:Receptor, Insulin; D007610:Kallikreins