title: Oral administration of antibodies as prophylaxis and therapy in Campylobacter jejuni-infected chickens.
abstract: Passive immunity against gastrointestinal infections has recently been successfully applied as prophylaxis and therapy in patients in a variety of virally and bacterially induced infections. Campylobacter jejuni is frequently associated with acute diarrhoea in humans, and several species of animals have been shown to transmit the disease, although birds have been implicated as the main source of infection. We used bovine and chicken immunoglobulin preparations from the milk and eggs, respectively, of immunized animals for prophylactic and therapeutic treatment of chickens infected with C. jejuni. A marked prophylactic effect (a >99% decrease in the number of bacteria) was noted using either antibody preparation, whereas the therapeutic efficacy, i.e. when antibodies were given after the infection was established, was distinctly lower (80-95%) as judged by faecal bacterial counts. These observations may serve as a starting point for experiments aimed at elimination of the infection in an industrial or farm setting. It may also encourage future attempts to treat, prophylactically or therapeutically, patients with Campylobacter-induced diarrhoea.
authors.affiliation: Department of Clinical Immunology, Huddinge Hospital, Sweden.
authors.forename: K
authors.initials: K
authors.lastname: Tsubokura
authors.forename: E
authors.initials: E
authors.lastname: Berndtson
authors.forename: A
authors.initials: A
authors.lastname: Bogstedt
authors.forename: B
authors.initials: B
authors.lastname: Kaijser
authors.forename: M
authors.initials: M
authors.lastname: Kim
authors.forename: M
authors.initials: M
authors.lastname: Ozeki
authors.forename: L
authors.initials: L
authors.lastname: Hammarström
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000907:Antibodies, Bacterial / Q000627:therapeutic use*; D002169:Campylobacter Infections / Q000517:prevention & control* / Q000628:therapy; D016123:Campylobacter jejuni / Q000276:immunology*; D002417:Cattle; D002645:Chickens; D005260:Female; D007116:Immunization, Passive
chemical_list: D000907:Antibodies, Bacterial