What does nisoldipine coat core (CC) add to current therapy that is clinically meaningful?
Nisoldipine coat core (CC) is a long-acting dihydropyridine with good tolerability. Ambulatory blood pressure measurements in a large, South African multicenter trial show that it has an excellent trough:peak ratio, and that it reduces the early morning rise in blood pressure without any tachycardia. Nisoldipine CC is an effective antihypertensive agent in both black and nonblack South African ethnic groups. In another South African study, regression of left ventricular hypertrophy was achieved in black patients with severe diastolic hypertension. Safety issues are discussed against the background of the testing of this drug in postinfarct left ventricular dysfunction.
Opie
L H
LH
Heart Research Unit, University of Cape Town, Medical School, South Africa.
D001794:Blood Pressure / Q000187:drug effects; D002121:Calcium Channel Blockers / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D003692:Delayed-Action Preparations; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000401:mortality; D017379:Hypertrophy, Left Ventricular / Q000188:drug therapy; D015337:Multicenter Studies as Topic; D015737:Nisoldipine / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D013019:South Africa
D002121:Calcium Channel Blockers; D003692:Delayed-Action Preparations; D015737:Nisoldipine