title: Adjuvant therapy with hydrolytic enzymes in recurrent laryngeal papillomatosis.
abstract: The subject of this study is systemic enzymotherapy as adjuvant treatment in recurrent laryngeal papillomatosis. The authors analyze their observations of 5 adult patients with recurrent laryngeal papillomatosis when after surgical extirpation and subsequent application of peroral proteases there was a significant improvement of their clinical state and laboratory results. The patients have been disease-free from 10 to 18 months. In the authors' experience, the adjuvant enzymotherapy seems to be a suitable replacement of the supplementary treatment in larynx papillomatosis, and it promises to decrease the recurrence rate as well.
authors.affiliation: Department of Otorhinolaryngology, P.J. Safárik University Hospital, Kosice, Slovak Republic.
authors.forename: J
authors.initials: J
authors.lastname: Mudrák
authors.forename: L
authors.initials: L
authors.lastname: Bobák
authors.forename: I
authors.initials: I
authors.lastname: Sebová
mesh_terms: D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000328:Adult; D000368:Aged; D004338:Drug Combinations; D006801:Humans; D006867:Hydrolases / Q000627:therapeutic use*; D007822:Laryngeal Neoplasms / Q000188:drug therapy* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy*; D010212:Papilloma / Q000188:drug therapy* / Q000601:surgery; D012431:Rutin / Q000627:therapeutic use*
chemical_list: D000276:Adjuvants, Immunologic; D004338:Drug Combinations; D012431:Rutin; C023295:Wobenzym; D006867:Hydrolases