title: Mononuclear blood cell magnesium content and serum magnesium concentration in critically ill hypomagnesemic patients after replacement therapy.
abstract: Magnesium (Mg) deficiency, commonly diagnosed as hypomagnesemia based upon low serum Mg concentrations, is a frequent electrolyte abnormality in critically ill patients. Intravenous replacement therapy is empiric and serum Mg concentrations have traditionally been used as guidelines for measuring efficacy. Recent studies have shown that the Mg content of mononuclear blood cells (MBCs) may provide a better index for Mg status than serum concentrations. The purpose of this study was to evaluate the effects of intravenous Mg replacement therapy on MBC Mg content and serum Mg concentrations in critically ill hypomagnesemic patients. Adult patients admitted to the trauma intensive-care unit (ICU) with serum Mg concentration < or = 0.6 mmol/L (< or = 1.5 mg/dL) were considered for study entry. Patients with severe renal disease (Scr > 133 mumol/L), pregnancy, or those who were seropositive for HIV were excluded. Ten patients with moderate (> 0.4-0.6 mmol/L [> 1.0-1.5 mg/dL]) and severe (< or = 0.4 mmol/L [< or = 1.0 mg/dL]) hypomagnesemia received 0.5 and 0.75 mmol/kg of intravenous MgSO4, respectively, over 24 h. MBC Mg content and serum concentrations of magnesium, phosphorus, calcium, sodium, potassium, blood urea nitrogen, creatinine, glucose, and albumin were measured at baseline (0 h), end of infusion (24 h), 36 h, and 48 h. Data were analyzed using ANOVA with repeated measures and a P value < 0.05 was considered significant. Serum Mg concentrations increased significantly from baseline to 48 h (0.5 +/- 0.1 to 0.8 +/- 0.2 mmol/L, P < 0.001). MBC Mg content did not change significantly within the study period (2.6 +/- 1.0 to 3.0 +/- 1.3 fmol/cell, P > 0.7). The doses of MgSO4 (0.5-0.75 mmol/kg) used in this study increased serum Mg concentrations, but did not result in a statistically significant change of MBC Mg content in this group of trauma ICU patients.
authors.affiliation: Department of Clinical Pharmacy, University of Tennessee, Memphis, USA.
authors.forename: G S
authors.initials: GS
authors.lastname: Sacks
authors.forename: R O
authors.initials: RO
authors.lastname: Brown
authors.forename: R N
authors.initials: RN
authors.lastname: Dickerson
authors.forename: S
authors.initials: S
authors.lastname: Bhattacharya
authors.forename: P D
authors.initials: PD
authors.lastname: Lee
authors.forename: C
authors.initials: C
authors.lastname: Mowatt-Larssen
authors.forename: G
authors.initials: G
authors.lastname: Ilardi
authors.forename: K A
authors.initials: KA
authors.lastname: Kudsk
mesh_terms: D000063:Accidents, Traffic; D000328:Adult; D016638:Critical Illness; D005260:Female; D006801:Humans; D007362:Intensive Care Units; D007963:Leukocytes, Mononuclear / Q000737:chemistry*; D008274:Magnesium / Q000097:blood* / Q000627:therapeutic use; D008275:Magnesium Deficiency / Q000097:blood / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D014947:Wounds and Injuries / Q000097:blood / Q000628:therapy; D014948:Wounds, Gunshot
chemical_list: D008274:Magnesium