title: [Cytomegalovirus infection in neonates. Diagnosis and therapeutic experiences].
abstract: Approximately 0.5-1% of all newborns are born infected with cytomegalovirus (CMV), but of these only one out of ten show symptoms at birth, most often with hepatosplenomegaly, thrombocytopenia, and/or brain affection. Of the remaining nine, one may later develop sequelae with hearing loss and/or mental retardation. CMV infection may also be acquired perinatally or in the newborn period, and may cause pneumonia and/or sepsis, possibly also gastrointestinal symptoms like blood in the stool, and poor weight-gain. We have diagnosed CMV infection in ten neonates and infants, and describe these patients in terms of symptoms, diagnosis and treatment. Ganciclovir is being tested in clinical trials as a treatment for congenital CMV infection, and was given to two of our patients with apparently good results.
authors.affiliation: Forsvarets sanitet, Oslo mil/Huseby.
authors.forename: R B
authors.initials: RB
authors.lastname: Fjaer
authors.forename: T G
authors.initials: TG
authors.lastname: Abrahamsen
authors.forename: A L
authors.initials: AL
authors.lastname: Bruu
authors.forename: T W
authors.initials: TW
authors.lastname: Hansen
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use; D003586:Cytomegalovirus Infections / Q000175:diagnosis / Q000188:drug therapy; D005260:Female; D015774:Ganciclovir / Q000627:therapeutic use; D005767:Gastrointestinal Diseases / Q000175:diagnosis / Q000188:drug therapy; D006801:Humans; D007231:Infant, Newborn
chemical_list: D000998:Antiviral Agents; D015774:Ganciclovir