Vascular biology of CD36: roles of this new adhesion molecule family in different disease states.
The human CD36 antigen is a scavenger receptor and a celladhesion molecule expressed by platelets, monocytes and microvascular endothelial cells, among other cell types. It belongs to a new and growing family of integral membrane glycoproteins that recognize a wide range of ligands. CD36 has been implicated in hemostasis, thrombosis, malaria, inflammation, lipid metabolism and atherogenesis. Recently, significant advances in CD36 biology have been reported and new CD36-like proteins have been identified.
Daviet
L
L
INSERM Unit 331, Faculty of Medicine RTH Laënnec, Lyon, France.
McGregor
J L
JL
D000818:Animals; D001161:Arteriosclerosis / Q000276:immunology; D018955:CD36 Antigens / Q000235:genetics / Q000276:immunology*; D015815:Cell Adhesion Molecules / Q000235:genetics / Q000276:immunology*; D004730:Endothelium, Vascular / Q000276:immunology*; D006801:Humans; D007249:Inflammation / Q000276:immunology; D050356:Lipid Metabolism; D016778:Malaria, Falciparum / Q000276:immunology; D014158:Transcription, Genetic
D018955:CD36 Antigens; D015815:Cell Adhesion Molecules