ADP-ribosylation of serum proteins: elevated levels in neoplastic cases due to altered NAD/ADP-ribose metabolism.
ADP-ribosylation of human serum proteins was studied in various groups of disorders. In most of these groups, the extent of ADP-ribosylation did not show a divergence from the group of normal controls. Neoplastic diseases revealed, however, a unique group, with more than fivefold increases in ADP-ribosylation levels over the other groups. Blood samples with high levels of ADP-ribosylation revealed, in general, increased serum NAD glycohydrolase activities and low levels of serum NAD.
Albeniz
I U
IU
Department of Biophysics, I.U. Istanbul Faculty of Medicine, Turkey.
Nurten
R
R
Bermek
E
E
D000246:Adenosine Diphosphate Ribose / Q000378:metabolism*; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000818:Animals; D015415:Biomarkers / Q000097:blood; D001798:Blood Proteins / Q000378:metabolism*; D001921:Brain / Q000201:enzymology; D002648:Child; D002675:Child, Preschool; D004194:Disease; D005260:Female; D006801:Humans; D007223:Infant; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D009243:NAD / Q000378:metabolism*; D009244:NAD+ Nucleosidase / Q000097:blood* / Q000378:metabolism; D009369:Neoplasms / Q000097:blood*; D012016:Reference Values; D012044:Regression Analysis; D012727:Sex Characteristics; D013552:Swine
D015415:Biomarkers; D001798:Blood Proteins; D009243:NAD; D000246:Adenosine Diphosphate Ribose; D009244:NAD+ Nucleosidase