Osteogenic protein-1 mRNA in the uterine endometrium.
OP-1, a bone morphogenetic protein (BMP) in the TGF-beta superfamily, is expressed at high levels in the kidney and in the endometrium of the uterus of non-pregnant mice. During pregnancy the OP-1 mRNA in the endometrium rapidly declined at 4 dpc. Thereafter, OP-1 transcripts were detected in the trophoblastic giant cells of the placenta and the fetal tissues. The uterine OP-1 mRNA downregulation could be mimicked by administration of 17 beta-estradiol but not by progesterone to non-pregnant animals. In contrast, OP-1 mRNA expression in kidneys and ovaries was not affected by pregnancy or estrogen treatment. The selective effect of estrogen on OP-1 mRNA in the uterus suggests that OP-1 expression is regulated by tissue specific mechanisms.
Ozkaynak
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Creative BioMolecules, Hopkinton, Massachusetts 01748, USA.
Jin
D F
DF
Jelic
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Vukicevic
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S
Oppermann
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H
D000818:Animals; D015152:Blotting, Northern; D055419:Bone Morphogenetic Protein 7; D019485:Bone Morphogenetic Proteins / Q000235:genetics* / Q000378:metabolism; D015536:Down-Regulation / Q000502:physiology; D004622:Embryo, Mammalian / Q000378:metabolism; D004717:Endometrium / Q000378:metabolism*; D004958:Estradiol / Q000494:pharmacology; D005260:Female; D005786:Gene Expression Regulation; D017403:In Situ Hybridization; D007668:Kidney / Q000378:metabolism; D051379:Mice; D010053:Ovary / Q000166:cytology / Q000378:metabolism; D010920:Placenta / Q000737:chemistry / Q000378:metabolism; D011247:Pregnancy; D011374:Progesterone / Q000494:pharmacology; D012333:RNA, Messenger / Q000378:metabolism*; D016212:Transforming Growth Factor beta
D055419:Bone Morphogenetic Protein 7; D019485:Bone Morphogenetic Proteins; D012333:RNA, Messenger; D016212:Transforming Growth Factor beta; D011374:Progesterone; D004958:Estradiol