title: [Primary pulmonary hypertension: treatment with prostacyclin before lung transplantation].
abstract: We report our experience with two patients diagnosed of primary pulmonary hypertension who later received lung transplants, with treatment with short-acting pulmonary vasodilators (epoprostenol) provided as a bridge to transplantation. Continuous intravenous perfusion at a dose of 6 ng/kg/min was provided to the first patient, a 19-year-old man, for 26 days. An initial dose of 4 ng/kg/min followed by 6 ng/kg/min was given to the second patient, a 49-year-old woman, for 6 months. Symptoms were drastically reduced in both patients, significantly improving their quality of life.
authors.affiliation: Servicio de Neumología, Hospital Universitario La Fe, Valencia.
authors.forename: P
authors.initials: P
authors.lastname: Morales
authors.forename: L
authors.initials: L
authors.lastname: Almenar
authors.forename: P J
authors.initials: PJ
authors.lastname: Cordero
authors.forename: R
authors.initials: R
authors.lastname: Vicente
authors.forename: F
authors.initials: F
authors.lastname: Ramos
authors.forename: J M
authors.initials: JM
authors.lastname: Borro
mesh_terms: D000328:Adult; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D002985:Clinical Protocols; D011464:Epoprostenol / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000188:drug therapy*; D016040:Lung Transplantation; D008297:Male; D008875:Middle Aged; D011300:Preoperative Care
chemical_list: D000959:Antihypertensive Agents; D011464:Epoprostenol