Genetic and biochemical analysis of TGF beta signal transduction.
TGF beta-like ligands are involved in many different developmental processes that pattern a variety of tissues in invertebrates and vertebrates. In the last few years, rapid progress has been made toward elucidating the developmental roles of the TGF beta-like pathways and identifying the novel components involved in transducing their signals, particularly the newly discovered Smads. This rapid progress has been the result of a synergy between classical genetic approaches and biochemical approaches, and this combined approach is likely to propel future understanding of the signaling pathway used by TGF beta.
Padgett
R W
RW
Department of Molecular Biology, Rutgers University, Piscataway, NJ 08835-0759, USA. padgett@mbcl.rutgers.edu
Savage
C
C
Das
P
P
D000818:Animals; D017173:Caenorhabditis elegans / Q000235:genetics / Q000502:physiology; D004268:DNA-Binding Proteins / Q000235:genetics / Q000502:physiology; D004330:Drosophila / Q000235:genetics / Q000502:physiology; D005260:Female; D016147:Genes, Tumor Suppressor; D006801:Humans; D008024:Ligands; D008297:Male; D008954:Models, Biological; D018125:Receptors, Transforming Growth Factor beta / Q000235:genetics / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology; D016212:Transforming Growth Factor beta / Q000235:genetics / Q000502:physiology*
D004268:DNA-Binding Proteins; D008024:Ligands; D018125:Receptors, Transforming Growth Factor beta; D016212:Transforming Growth Factor beta