[The contribution of presynaptic dopaminergic receptors to the mechanism of the reactivating influences of blockade of the GABA-benzodiazepine-ionophor complex].
The changes in reactivating efficiency of the GABA-benzodiazepine-ionophore complex blockade were examined in mice after preliminary activation or inhibition of dopamine autoreceptors by (+)3PPP (2 mg/kg) and haloperidol (0.01 mg/kg). The passive avoidance learning task and amnesia produced by detention of a mouse in the dangerous compartment were used. The pretest injections of bicuculline (1 mg/kg), picrotoxin (1 mg/kg), and flumazenil (10 mg/kg) recovered the passive avoidance response in mice injected with saline before training. Pretreatment with the dopamine autoreceptor agonist and antagonist prevented from the recovery of amnestic memory trace induced by blockade of GABA-benzodiazepine-ionophore complex components. The results imply the involvement of dopamine/GABA-dependent mechanism in the modulation of memory trace retrieval.
Dubrovina
N I
NI
Il'iuchenok
R Iu
RIu
D000818:Animals; D017660:Autoreceptors / Q000187:drug effects / Q000502:physiology; D001362:Avoidance Learning / Q000187:drug effects / Q000502:physiology; D001640:Bicuculline / Q000494:pharmacology; D003214:Conditioning, Classical / Q000187:drug effects / Q000502:physiology; D018491:Dopamine Agonists / Q000494:pharmacology; D018492:Dopamine Antagonists / Q000494:pharmacology; D004347:Drug Interactions; D005442:Flumazenil / Q000494:pharmacology; D018756:GABA Antagonists / Q000494:pharmacology; D018757:GABA Modulators / Q000494:pharmacology; D058787:GABA-A Receptor Antagonists; D006220:Haloperidol / Q000494:pharmacology; D007476:Ionophores / Q000037:antagonists & inhibitors*; D008568:Memory / Q000187:drug effects / Q000502:physiology; D051379:Mice; D008807:Mice, Inbred BALB C; D010852:Picrotoxin / Q000494:pharmacology; D011954:Receptors, Dopamine / Q000187:drug effects* / Q000502:physiology; D011963:Receptors, GABA-A / Q000187:drug effects / Q000502:physiology; D017661:Receptors, Presynaptic / Q000187:drug effects* / Q000502:physiology
D017660:Autoreceptors; D001640:Bicuculline; D018491:Dopamine Agonists; D018492:Dopamine Antagonists; D005442:Flumazenil; D018756:GABA Antagonists; D018757:GABA Modulators; D058787:GABA-A Receptor Antagonists; D006220:Haloperidol; D007476:Ionophores; D010852:Picrotoxin; D011954:Receptors, Dopamine; D011963:Receptors, GABA-A; D017661:Receptors, Presynaptic