title: [Botulinum toxin in spastic infantile cerebral palsy: results in 27 cases during one year].
abstract: OBJECTIVE
  Positive outcome of patients with spastic cerebral palsy treated with botulinum toxin reported in the last three years has led us to perform this study with the aim to show our experience in the management of spastic cerebral palsy with the toxin, determine its indications, analyze the results and propose new possible indications in the future.
  
  
  METHODS
  We include 10 hemiplegic and 17 diplegic patients with an average age of 6 years and 7 months, followed up between 5 and 17 months. Clinical improvement was monitored using the PRS and EVFEL scales and articular motion range was measured 6 months before and after the injection while continuing physiotherapy. The injected muscles were adductor, hamstrings, triceps and posterior tibialis, and the doses were 1-2 U/muscle/kg body weight.
  
  
  RESULTS
  The values on PRS improved an average of 24%, adductor angle 66% (p < 0.01), knee angle 40% (p = 0.05) and ankle angle 52% (p < 0.01); 96% of patients could get more physiological static or walking patterns because of the decrease of spasticity and those persisted after the effect of the toxin had worn off. It was maximum at 2 months, stabilized 4 to 6 months later and decreased during further 2 months.
  
  
  CONCLUSIONS
  This experience leads us to propose higher starting dosage and to take into account the stability of postural pattern of each patient to choice the muscle to be injected. Other therapeutic possibilities are also proposed in children with fixed shortening e.g. combining the toxin with stretching casts.
authors.affiliation: Dpto. de Pediatría, Clínica Universitaria de Navarra, Pamplona, Espaã.
authors.forename: R
authors.initials: R
authors.lastname: Sánchez-Carpintero
authors.forename: J
authors.initials: J
authors.lastname: Narbona
mesh_terms: D000293:Adolescent; D019274:Botulinum Toxins, Type A / Q000008:administration & dosage / Q000627:therapeutic use*; D002547:Cerebral Palsy / Q000150:complications*; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D005500:Follow-Up Studies; D006801:Humans; D009128:Muscle Spasticity / Q000150:complications* / Q000188:drug therapy* / Q000628:therapy; D026741:Physical Therapy Modalities; D016896:Treatment Outcome
chemical_list: D019274:Botulinum Toxins, Type A