title: Detection of significant residual stenosis of the infarct-related artery after thrombolysis by high-dose dipyridamole echocardiography test: is it detected often enough?
abstract: OBJECTIVE
  It has been reported that high-dose dipyridamole echocardiography test (DET) can be successfully used for the detection of critical residual stenosis of the infarct-related artery (IRA). However, we have recently noticed low sensitivity of DET for the detection of residual IRA stenosis in patients with single-vessel disease. This study sought to determine the value of DET for the detection of significant residual stenosis of the IRA after thrombolysis.
  
  
  METHODS
  Dipyridamole echocardiography test was performed in 55 consecutive patients after a first acute myocardial infarction before hospital discharge. All patients underwent coronary angiography 23 +/- 6 days after infarction.
  
  
  RESULTS
  Nine of 19 patients with positive DET revealed new adjacent asynergy and all of the patients had patient and significantly stenotic IRA. Sensitivity and specificity of DET in identifying significant residual stenosis of the IRA were 24 and 100%, respectively. Among 49 patients with significantly stenotic of occluded IRA, 40 patients without adjacent asynergy during DET had higher baseline wall motion score index (WMSI) compared with 9 patients who revealed adjacent asynergy during DET (1.45 +/- 0.30 vs. 1.24 +/- 0.18; p < 0.05). When all patients with positive DET (adjacent or remote asynergy) were compared with those with negative DET, no difference in baseline WMSI was found (1.37 +/- 0.24 vs. 1.44 +/- 0.24; p > 0.05).
  
  
  CONCLUSIONS
  Our data indicate that sensitivity of DET in detecting significant residual stenosis of the IRA after thrombolysis is low. It seems that the extent of myocardial infarction affects the ability of DET to detect adjacent, but not remote asynergy.
authors.affiliation: Cardiovascular Research Center, Dedinje Cardiovascular Institute, Belgrade, Yugoslavia.
authors.forename: A N
authors.initials: AN
authors.lastname: Nesković
authors.forename: M
authors.initials: M
authors.lastname: Bojić
authors.forename: A D
authors.initials: AD
authors.lastname: Popović
mesh_terms: D000368:Aged; D003327:Coronary Disease / Q000000981:diagnostic imaging*; D004176:Dipyridamole; D004452:Echocardiography / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications* / Q000000981:diagnostic imaging / Q000188:drug therapy; D015588:Observer Variation; D012680:Sensitivity and Specificity; D018709:Statistics, Nonparametric; D015912:Thrombolytic Therapy
chemical_list: D004176:Dipyridamole