Endothelial injury of capillaries in the stria vascularis of guinea pigs treated with cisplatin and gentamicin.
The drugs cisplatin and gentamicin are used for treatment of various cancer patients suffering from infection. The authors report a detailed electron microscopic study of blood vessels in stria vascularis of guinea pigs after treatment with cisplatin alone and in combination with gentamicin. The most distinctive features expressing endothelial cellular injury were mitochondrial, including occasional paracrystalline inclusions; electron-lucent foci with depleted organelles; intracytoplasmic vacuole formations; lipid bodies; cytoplasmic extrusions located on the luminal surface; and severe luminal constriction of part of the vessels from animals treated with the combined drugs. The study suggests that the damage to strial capillaries due to treatment with cisplatin alone and in combination with gentamicin may contribute to the injurious effects of these drugs on the strial tissue. Furthermore, the results of this study may enlarge the awareness of the potential vascular damage and vascular complications in additional body systems after medical use of cisplatin alone or in combination with gentamicin.
Kohn
S
S
Electron Microscopy Unit, Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
Fradis
M
M
Podoshin
L
L
Ben-David
J
J
Zidan
J
J
Robinson
E
E
D000818:Animals; D000900:Anti-Bacterial Agents / Q000009:adverse effects; D000970:Antineoplastic Agents / Q000009:adverse effects; D002196:Capillaries / Q000187:drug effects / Q000648:ultrastructure*; D002945:Cisplatin / Q000009:adverse effects*; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000648:ultrastructure*; D005839:Gentamicins / Q000009:adverse effects*; D006168:Guinea Pigs; D008854:Microscopy, Electron; D008928:Mitochondria / Q000187:drug effects / Q000648:ultrastructure; D013316:Stria Vascularis / Q000648:ultrastructure*
D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D005839:Gentamicins; D002945:Cisplatin