title: Two patients with recurrent melioidosis after prolonged antibiotic therapy.
abstract: Melioidosis is a tropical infectious disease caused by Burkholderia (Pseudomonas) pseudomalleï. Clinically manifest melioidosis occurs mostly in people with underlying disorders. Melioidosis is a disease with protein manifestations and a high rate of relapse. Two patients with infection due to Burkholderia pseudomalleï after a visit to Thailand are described. Both patients presented with sepsis and appropriate therapy was initiated and continued for several months. Despite such long-term antimicrobial treatment, both patients had a relapse after cessation of therapy. It is unclear if recurrent melioidosis can be prevented by prolonging the treatment even further.
authors.affiliation: Department of Hematology, University Hospital Rotterdam, The Netherlands.
authors.forename: M H
authors.initials: MH
authors.lastname: Silbermann
authors.forename: I C
authors.initials: IC
authors.lastname: Gyssens
authors.forename: H P
authors.initials: HP
authors.lastname: Endtz
authors.forename: E J
authors.initials: EJ
authors.lastname: Kuijper
authors.forename: J T
authors.initials: JT
authors.lastname: van der Meer
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D016957:Burkholderia pseudomallei; D004359:Drug Therapy, Combination; D006801:Humans; D008297:Male; D008554:Melioidosis / Q000188:drug therapy* / Q000382:microbiology; D008875:Middle Aged; D012008:Recurrence; D013785:Thailand
chemical_list: D000900:Anti-Bacterial Agents