title: Calcium carbonate apatite deposition in the cervical spine with associated vertebral destruction. Case report.
abstract: This 52-year-old woman developed crystal deposition disease involving the cervical vertebrae. She presented with symptomatic spinal cord compression secondary to extensive calcified lesions in the posterior elements of the cervical spine. Surgical decompression with posterior fusion was performed. Histological examination showed hardened deposits of calcium carbonate involving the soft tissue, and dissolution of the vertebral bone trabeculae. There was no inflammatory response to these deposits. One year postoperatively the patient developed severe pulmonary disease associated with the collagen-vascular disorder, scleroderma (calcinosis, Raynaud's phenomenon, esophageal hypomotility, sclerodactyly, and telangiectasia [CREST] syndrome). Calcium carbonate deposition disease represents an unusual clinical entity that is possibly associated with scleroderma or other collagen-vascular diseases, and it is distinct from ligamentum flavum calcification, calcium pyrophosphate deposition disease, and hydroxyapatite deposition disease.
authors.affiliation: Department of Neurological Surgery, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
authors.forename: J G
authors.initials: JG
authors.lastname: Ojemann
authors.forename: R L
authors.initials: RL
authors.lastname: Grubb
authors.forename: M
authors.initials: M
authors.lastname: Kyriakos
authors.forename: K B
authors.initials: KB
authors.lastname: Baker
mesh_terms: D001031:Apatites / Q000378:metabolism*; D002119:Calcium Carbonate / Q000378:metabolism*; D002574:Cervical Vertebrae / Q000000981:diagnostic imaging* / Q000378:metabolism* / Q000473:pathology; D003460:Crystallization; D005260:Female; D006801:Humans; D008875:Middle Aged; D013117:Spinal Cord Compression / Q000000981:diagnostic imaging / Q000209:etiology / Q000601:surgery; D014057:Tomography, X-Ray Computed
chemical_list: D001031:Apatites; D002119:Calcium Carbonate