[Bacterial endotoxins produced by Alcaligenes faecalis and Erwinia herbicola as potential occupational hazards for agricultural workers].
Laboratory animals (guinea pigs and rabbits) were exposed to the inhalation of aerosolized endotoxins derived from the cell mass of Alcaligenes faecalis and Erwinia herbicola, the Gram-negative bacteria commonly occurring in organic dusts. Single 1 hour-lasting exposure caused the significant increase in the number of free lung cell, mostly lymphocytes, compared to the control group exposed to saline (P < 0.001). Prolonged exposure to tested endotoxins (Fifteen 1 hour-lasting exposures every second day) caused both specific and non specific immunological changes: enhanced inhibition of leukocyte migration production of precipitins, and activation of alveolar macrophages, wes assessed by greater antibacterial activity and increased interleukin I (IL-I) production. The results indicate that the endotoxins of examined bacteria represent a potential risk of inflammatory lung reaction and respiratory disease for agricultural workers inhaling organic dusts contaminated with these organisms.
Skórska
C
C
Zakładu Aerobiologii i Alergologii, Instytutu Medycyny Wsi w Lublinie.
Milanowski
J
J
Dutkiewicz
J
J
Fafrowicz
B
B
D000280:Administration, Inhalation; D000421:Alcaligenes; D000818:Animals; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology; D004391:Dust / Q000009:adverse effects / Q000032:analysis; D004731:Endotoxins / Q000633:toxicity*; D004784:Environmental Monitoring; D004885:Erwinia; D005203:Farmer's Lung / Q000517:prevention & control; D006168:Guinea Pigs; D006801:Humans; D007375:Interleukin-1 / Q000096:biosynthesis; D018655:Lymphocyte Count / Q000187:drug effects; D008262:Macrophage Activation / Q000187:drug effects; D016676:Macrophages, Alveolar / Q000187:drug effects*; D016273:Occupational Exposure; D011817:Rabbits
D004391:Dust; D004731:Endotoxins; D007375:Interleukin-1