Site-specific intravascular administration of drugs: history of a method applicable in humans.
Demonstration and quantification of site-specific intracoronary administration of pharmacological compounds has been limited thus far to animal experimental models. Recently, a method applicable in humans has been developed. The aim of this study is to give an overview on the available methods to visualize and quantify intravascularly administered "labeled" drugs in animals and to describe the historical development of a method now applied in the clinical arena. The potential of this approach is briefly summarized.
Camenzind
E
E
Thoraxcenter, University Hospital Dijkzigt, Rotterdam, The Netherlands.
Bakker
W H
WH
Reijs
A
A
van Geijlswijk
I M
IM
Foley
D
D
Krenning
E P
EP
Roelandt
J R
JR
Serruys
P W
PW
D000368:Aged; D000784:Aortic Dissection / Q000000981:diagnostic imaging; D000789:Angina, Unstable / Q000000981:diagnostic imaging / Q000188:drug therapy*; D015906:Angioplasty, Balloon, Coronary / Q000295:instrumentation*; D000818:Animals; D000925:Anticoagulants / Q000008:administration & dosage*; D003323:Coronary Aneurysm / Q000000981:diagnostic imaging / Q000188:drug therapy; D016503:Drug Delivery Systems / Q000295:instrumentation*; D005240:Feasibility Studies; D006493:Heparin / Q000008:administration & dosage*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D009203:Myocardial Infarction / Q000000981:diagnostic imaging / Q000188:drug therapy*; D011877:Radionuclide Imaging; D015912:Thrombolytic Therapy / Q000295:instrumentation*; D016896:Treatment Outcome
D000925:Anticoagulants; D006493:Heparin