Effects of chronic ibogaine treatment on cerebellar Purkinje cells in the rat.
The present investigation assessed the chronic toxicity of ibogaine on cerebellar Purkinje cells in male Fischer 344 rats. A behaviorally active dose of ibogaine (10 mg/kg, i.p.) was administered to a group of six subjects every other day for 60 days while the control group received an equivalent volume of saline (1 ml/kg). Estimates of Purkinje cell number were determined using the optical dissector/fractionator technique. No significant differences in Purkinje cell number were observed between the ibogaine (243764[+/-32766]) and control groups (230813[+/-16670]).
Helsley
S
S
Department of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, 14214-3000, USA.
Dlugos
C A
CA
Pentney
R J
RJ
Rabin
R A
RA
Winter
J C
JC
D000818:Animals; D002531:Cerebellum / Q000187:drug effects*; D007050:Ibogaine / Q000494:pharmacology*; D008297:Male; D011689:Purkinje Cells / Q000187:drug effects*; D051381:Rats; D011916:Rats, Inbred F344; D013997:Time Factors
D007050:Ibogaine