Validation of ion chromatographic methods for the trace analysis of ions in pharmacopoeial grades of water.
Ion chromatography was investigated as an alternative technique to conventional pharmacopoeial methods for the determination of inorganic anions and cations in pharmacopoeial grades of water. These methods were validated by generating data on parameters such as specificity, linearity, precision, accuracy, sensitivity, ruggedness and stability of solution. The validation data demonstrate that ion chromatography is a viable alternative technique to current pharmacopoeial methods which enables automation of pharmacopoeial water analyses.
Waterworth
J P
JP
SmithKline Beecham Pharmaceuticals, Welwyn Garden City, Herts., UK.
D000838:Anions / Q000032:analysis*; D002412:Cations / Q000032:analysis*; D002852:Chromatography, Ion Exchange / Q000379:methods*; D015203:Reproducibility of Results; D014867:Water / Q000032:analysis*
D000838:Anions; D002412:Cations; D014867:Water