Effect of hyperglycemia on the intestinal elimination of p-nitrophenol in the rat.
Effect of hyperglycemia on the intestinal elimination of p-nitrophenol has been investigated in rats. Hyperglycemia was produced by a continuous i.v. infusion of glucose, p-nitrophenol was used as a model compound for the investigation of intestinal metabolism and excretion of drugs. Intestinal conjugation of p-nitrophenol with glucuronic acid did not change significantly in hyperglycemic rats, however, formation of sulfoconjugate of p-nitrophenol was enhanced by hyperglycemia. Sum of metabolites (p-nitrophenol glucuronide and sulfate) appeared in the intestinal lumen in hyperglycemic rats was similar to the total luminal appearance of these metabolites of control rats.
Fischer
E
E
Department of Pharmacology, University Medical School, Pécs, Hungary.
Rafiei
A
A
Bojcsev
S
S
D000818:Animals; D005965:Glucuronates / Q000378:metabolism; D006943:Hyperglycemia / Q000378:metabolism*; D007413:Intestinal Mucosa / Q000378:metabolism*; D009578:Nitrobenzenes / Q000378:metabolism; D009596:Nitrophenols / Q000378:metabolism*; D051381:Rats; D012016:Reference Values
D005965:Glucuronates; D009578:Nitrobenzenes; D009596:Nitrophenols; C049288:p-nitrophenol glucuronide; C023379:4-nitrophenyl sulfate; C024836:4-nitrophenol