A new uncoupling protein: a potential component of the human body weight regulation system.
A mitochondrial protein that uncouples the respiratory chain from oxidative phosphorylation and generates heat is found in brown adipose tissue (BAT) of rodents. Although humans have little BAT, a second uncoupling protein has been discovered that is widely distributed in human tissues. It is induced in mice by a high-fat diet and in mice with obese mutations, and may play a role in human body weight regulation.
Wolf
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Department of Nutritional Sciences, University of California, Berkeley 94720-3104, USA.
D002001:Adipose Tissue, Brown / Q000737:chemistry*; D000818:Animals; D006801:Humans; D020738:Leptin; D051379:Mice; D008810:Mice, Inbred C57BL; D011506:Proteins / Q000494:pharmacology*; D014475:Uncoupling Agents / Q000494:pharmacology*; D015431:Weight Loss
D020738:Leptin; D011506:Proteins; D014475:Uncoupling Agents