Oxidative metabolism in insulin-treated gestational diabetes mellitus.
To investigate whether protein, carbohydrate, and fat metabolism was normalized in insulin-treated gestational diabetes mellitus (GDM), eight Hispanic women with GDM and eight healthy controls were studied at 32-36 wk of gestation and 6 wk postpartum. Net substrate utilization was measured using room respiration calorimetry. Exogenous substrate oxidation was determined by 13C recovered in breath CO2 from 13C-labeled leucine, glucose, and Hiolein. Women with GDM had higher 24-h oxygen consumption, carbon dioxide production, total energy expenditure, and basal metabolic rates than controls due to larger body mass. Adjusted for weight or fat-free mass, total energy expenditure, basal metabolic rate, and basal and 24-h whole body net protein, carbohydrate, and fat utilization did not differ between insulin-treated GDM subjects and controls in pregnancy or postpartum. Oxidation of [13C]leucine and [13C]glucose did not differ by group or pregnancy status. Recovery of exogenously administered [13C]Hiolein, a biosynthetic triglyceride, as breath 13CO2 was significantly lower in the GDM group antepartum and postpartum (P = 0.02), indicating lower oxidation of exogenous triglycerides in GDM.
Hsu
H W
HW
Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas 77030, USA.
Butte
N F
NF
Wong
W W
WW
Moon
J K
JK
Ellis
K J
KJ
Klein
P D
PD
Moise
K J
KJ
D000273:Adipose Tissue / Q000033:anatomy & histology; D000293:Adolescent; D000328:Adult; D001481:Basal Metabolism; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight; D002245:Carbon Dioxide / Q000032:analysis; D002247:Carbon Isotopes; D016640:Diabetes, Gestational / Q000188:drug therapy / Q000378:metabolism*; D004734:Energy Metabolism; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D005934:Glucagon / Q000097:blood; D005947:Glucose / Q000378:metabolism; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D007328:Insulin / Q000097:blood / Q000627:therapeutic use*; D007930:Leucine / Q000378:metabolism; D010084:Oxidation-Reduction; D010101:Oxygen Consumption; D049590:Postpartum Period / Q000378:metabolism*; D011247:Pregnancy / Q000378:metabolism*; D014280:Triglycerides / Q000097:blood / Q000378:metabolism
D001786:Blood Glucose; D002245:Carbon Dioxide; D002247:Carbon Isotopes; D005230:Fatty Acids, Nonesterified; D005934:Glucagon; D005947:Glucose; D006442:Glycated Hemoglobin; D006854:Hydrocortisone; D007004:Hypoglycemic Agents; D007328:Insulin; D007930:Leucine; D014280:Triglycerides