Xid and Xid-like immunodeficiencies from a signaling point of view.
The analysis of Btk-associated molecules and ligand-induced Btk phosphorylation has suggested the existence of a complexed Btk-associated signaling network involved in the activation of B lymphocytes and mast cells. Recent gene targeting experiments have revealed protein kinase C betaI/II (PKCbetaI/II) as a critical component of the Btk-dependent signaling chain and have highlighted a potential role for the Btk-PKCbetaI/II interaction in the amplification of B cell receptor mediated signaling.
Tarakhovsky
A
A
Institute for Genetics, University of Cologne, Weyertal 121, 50931, Cologne, Germany. sasha@genetik.uni-koeln.de
D000077329:Agammaglobulinaemia Tyrosine Kinase; D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D008040:Genetic Linkage; D006801:Humans; D007154:Immune System Diseases / Q000235:genetics / Q000276:immunology*; D051379:Mice; D011505:Protein-Tyrosine Kinases / Q000235:genetics* / Q000276:immunology; D015398:Signal Transduction / Q000235:genetics* / Q000276:immunology; D014960:X Chromosome
D011505:Protein-Tyrosine Kinases; D000077329:Agammaglobulinaemia Tyrosine Kinase; C000625949:BTK protein, human; C000625951:Btk protein, mouse