title: Positron-emission tomography imaging of long-term shape recognition challenges.
abstract: Long-term visual memory performance was impaired by two types of challenges: a diazepam challenge on acquisition and a sensory challenge on recognition. Using positron-emission tomography regional cerebral blood flow imaging, we studied the effect of these challenges on regional brain activation during the delayed recognition of abstract visual shapes as compared with a baseline fixation task. Both challenges induced a significant decrease in differential activation in the left fusiform gyrus, suggesting that this region is involved in the automatic or volitional comparison of incoming and stored stimuli. In contrast, thalamic differential activation increased in response to memory challenges. This increase might reflect enhanced retrieval attempts as a compensatory mechanism for restoring recognition performance.
authors.affiliation: Laboratorium voor Neuro- en Psychofysiologie, Universite Catholique de Leuven Medical School, Campus Gasthuisberg, Herestraat 49, B-3000 Leuven, Belgium. Anne-Marie.Rosier@med.kuleuven.ac.be
authors.forename: A
authors.initials: A
authors.lastname: Rosier
authors.forename: L
authors.initials: L
authors.lastname: Cornette
authors.forename: P
authors.initials: P
authors.lastname: Dupont
authors.forename: G
authors.initials: G
authors.lastname: Bormans
authors.forename: J
authors.initials: J
authors.lastname: Michiels
authors.forename: L
authors.initials: L
authors.lastname: Mortelmans
authors.forename: G A
authors.initials: GA
authors.lastname: Orban
mesh_terms: D000328:Adult; D006801:Humans; D008297:Male; D011939:Mental Recall / Q000502:physiology*; D014055:Tomography, Emission-Computed; D014796:Visual Perception / Q000502:physiology*