title: The feet in Crouzon syndrome.
abstract: Eighteen patients with Crouzon syndrome were evaluated for anomalies of the feet. Clinical examination was unremarkable in all cases. Radiographs were evaluated by a radiologist with an interest in skeletal dysplasia, along with the craniofacial team. A range of radiographic anomalies was seen, with the phalanges, metacarpals, and tarsals all displaying anomalies. Only three cases had radiographically normal feet. These findings suggest that the effects on the feet, which, although subtle and not well described in the literature, are notable. Feet anomalies also occur with the other complex craniosynostosis syndromes resulting from mutations of fibroblastic growth factor receptor 2 molecule, such as those of Apert, Pfeiffer, and Jackson-Weiss syndromes.
authors.affiliation: Department of Craniofacial Surgery, Great Ormond Street Hospital for Children, London, UK.
authors.forename: P J
authors.initials: PJ
authors.lastname: Anderson
authors.forename: C M
authors.initials: CM
authors.lastname: Hall
authors.forename: R D
authors.initials: RD
authors.lastname: Evans
authors.forename: B M
authors.initials: BM
authors.lastname: Jones
authors.forename: R D
authors.initials: RD
authors.lastname: Hayward
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003394:Craniofacial Dysostosis / Q000150:complications / Q000473:pathology*; D018450:Disease Progression; D005260:Female; D005532:Foot Deformities, Congenital / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology; D006801:Humans; D007223:Infant; D008297:Male; D011446:Prospective Studies; D011859:Radiography