Fine mapping of the human renal oncocytoma-associated translocation (5;11)(q35;q13) breakpoint.
Recent cytogenetic analysis of a series of human renal oncocytomas revealed the presence of a recurring chromosomal translocation (5;11)(q35;q13) as sole anomaly in a subset of the tumors. The molecular characterization of this translocation was initiated using two primary t(5;11)-positive renal oncocytomas and a panel of somatic cell hybrids derived from one of these tumors, in conjunction with fluorescence in situ hybridization (FISH) and Southern blot analysis. The breakpoint in chromosome band 11q13 could be located within a genomic interval of at maximum 400 Kb immediately centromeric to the BCL1 locus.
Sinke
R J
RJ
Department of Human Genetics, University Hospital, Nijmegen, The Netherlands.
Dijkhuizen
T
T
Janssen
B
B
Olde Weghuis
D
D
Merkx
G
G
van den Berg
E
E
Schuuring
E
E
Meloni
A M
AM
de Jong
B
B
Geurts van Kessel
A
A
D018249:Adenoma, Oxyphilic / Q000235:genetics*; D002869:Chromosome Aberrations / Q000235:genetics*; D002871:Chromosome Banding; D025063:Chromosome Disorders; D002874:Chromosome Mapping; D002880:Chromosomes, Human, Pair 11; D002895:Chromosomes, Human, Pair 5; D005819:Genetic Markers; D006801:Humans; D006822:Hybrid Cells; D017404:In Situ Hybridization, Fluorescence; D007680:Kidney Neoplasms / Q000235:genetics*; D014178:Translocation, Genetic
D005819:Genetic Markers