Bone mineralization and turnover in children with congenital neutropenia, and its relationship to treatment with recombinant human granulocyte-colony stimulating factor.
Bone mineral content (BMC) of the radius was measured using single photon absorptiometry (SPA) in nine children with congenital neutropenia. Five had normal values. Two children with severe congenital neutropenia (SCN) had low BMC, and two boys with Schwachman syndrome had biochemistry suggestive of rickets.
Fewtrell
M S
MS
MRC Dunn Nutrition Unit, Department of Paediatrics, Addenbrooke's Hospital, Cambridge.
Kinsey
S E
SE
Williams
D M
DM
Bishop
N J
NJ
D015502:Absorptiometry, Photon; D000293:Adolescent; D001851:Bone Diseases, Metabolic / Q000209:etiology / Q000503:physiopathology; D002118:Calcium / Q000008:administration & dosage; D002648:Child; D015444:Exercise; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D009503:Neutropenia / Q000151:congenital / Q000503:physiopathology* / Q000628:therapy; D011994:Recombinant Proteins / Q000627:therapeutic use
D011994:Recombinant Proteins; D016179:Granulocyte Colony-Stimulating Factor; D002118:Calcium