title: Prognostic indicators for survival after curative resection for patients with carcinoma of the stomach.
abstract: This study aims to determine prognostic indicators among patient-, tumor-, and treatment-related factors of gastric cancer patients. A total of 510 patients who underwent curative gastric resection were studied. Univariate analysis of patient-related factors showed a significantly lower survival in patients with a history of obstruction, hypoalbuminemia, and anemia. Tumor-related factors including gross appearance, location, and size of tumor; depth of cancer invasion; level, number, and frequency of lymph node metastasis; stromal reaction and tumor growth pattern; and histological classification all significantly affected survival. Surgical treatment related factors such as total or distal subtotal gastrectomy, extent of lymphadenectomy, and combined resection of adjacent organ(s) showed a statistically significant adverse influence on survival. Multivariate analysis identified only four tumor-related factors-number of metastatic lymph nodes, depth of cancer invasion, stromal reaction, and gross appearance of the tumor-as independently affecting survival. These findings suggest that only four tumor-related factors were prognostic indicators in patients with gastric cancer.
authors.affiliation: Department of Surgery, Veterans General Hospital-Taipei, Taiwan.
authors.forename: C W
authors.initials: CW
authors.lastname: Wu
authors.forename: M C
authors.initials: MC
authors.lastname: Hsieh
authors.forename: S S
authors.initials: SS
authors.lastname: Lo
authors.forename: S H
authors.initials: SH
authors.lastname: Tsay
authors.forename: A F
authors.initials: AF
authors.lastname: Li
authors.forename: W Y
authors.initials: WY
authors.lastname: Lui
authors.forename: F K
authors.initials: FK
authors.lastname: P'eng
mesh_terms: D000230:Adenocarcinoma / Q000401:mortality* / Q000473:pathology / Q000601:surgery*; D000368:Aged; D005260:Female; D005743:Gastrectomy; D006801:Humans; D008197:Lymph Node Excision; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000401:mortality* / Q000473:pathology / Q000601:surgery*; D015996:Survival Rate