Single-unit activity in the primate nucleus tegmenti pedunculopontinus related to voluntary arm movement.
In the pedunculopontine tegmental nucleus (PPN), single-unit activity was recorded in two monkeys trained to manipulate an on-off lever with a hand. Among 280 neurons recorded, a change in the firing rate related to the lever-off movement was observed in 125 neurons for the contralateral limb movement (53%) and in 96 neurons for the ipsilateral limb movement (48%). The changes were an increase in the firing rate in 122 neurons and a decrease in 99 neurons. These changes in the firing rate related to the task often occurred for both the contralateral and ipsilateral limb movements. The change of activity preceded the movement onset for both contralateral and ipsilateral arm movements. These findings suggest that in primates the PPN contributes to coordination of upper limb movements on both sides.
Matsumura
M
M
Department of Neurosurgery, Gunma University School of Medicine, Japan. nsmatsu@news.sb.gunma-u.ac.jp
Watanabe
K
K
Ohye
C
C
D000818:Animals; D001132:Arm / Q000502:physiology*; D001931:Brain Mapping; D004594:Electrophysiology; D005260:Female; D008251:Macaca / Q000502:physiology*; D008297:Male; D009068:Movement / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D013681:Tegmentum Mesencephali / Q000166:cytology / Q000502:physiology*; D014836:Volition