Glucagon-like peptide-1 7-36 amide and peptide YY have additive inhibitory effect on gastric acid secretion in man.
BACKGROUND
Glucagon-like peptide-1 7-36 amide (GLP-1) and peptide YY (PYY) are colocalized in the L-cell of the ileal mucosa, and both peptides may function as enterogastrone hormones. However, it is not known whether they interact with regard to the effect on acid secretion.


METHODS
The effect of intravenous infusion of GLP-1 and PYY, either alone or in combination, on pentagastrin-induced acid secretion in eight healthy volunteers was examined. The peptides were infused at two different rates: 0.25 pmol/kg/min (low rate) and 0.5 pmol/kg/min (high rate).


RESULTS
Given alone, GLP-1 and PYY inhibited acid secretion by 26 +/- 5% and 18 +/- 5% (low rate) and 45 +/- 8% and 38 +/- 7% (high rate), respectively. Combined infusion resulted in an inhibition of 32 +/- 5% (low rate) and 62 +/- 7% (high rate). Both infusion rates resulted in GLP-1 and PYY plasma concentrations below or similar to postprandial levels.


CONCLUSIONS
The present study suggests that the interaction between GLP-1 and PYY in man is of the additive type. The results indicate that GLP-1 and PYY have an important role in the physiologic control of gastric acid secretion.
Wettergren
A
A
Dept. of Gastrointestinal Surgery D, Glostrup Hospital, Denmark.
Maina
P
P
Boesby
S
S
Holst
J J
JJ
D000328:Adult; D004347:Drug Interactions; D005260:Female; D005744:Gastric Acid / Q000378:metabolism*; D005768:Gastrointestinal Hormones / Q000008:administration & dosage / Q000494:pharmacology* / Q000502:physiology; D005934:Glucagon; D052216:Glucagon-Like Peptide 1; D004763:Glucagon-Like Peptides; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D018377:Neurotransmitter Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000502:physiology; D010418:Pentagastrin; D010446:Peptide Fragments / Q000008:administration & dosage / Q000494:pharmacology* / Q000502:physiology; D019894:Peptide YY; D010455:Peptides / Q000008:administration & dosage / Q000494:pharmacology* / Q000502:physiology
D005768:Gastrointestinal Hormones; D018377:Neurotransmitter Agents; D010446:Peptide Fragments; D010455:Peptides; D019894:Peptide YY; C055453:glucagon-like peptide 1 (7-36)amide; D004763:Glucagon-Like Peptides; D052216:Glucagon-Like Peptide 1; D005934:Glucagon; D010418:Pentagastrin