[Image morphological quantitative analysis of pathological changes of intra-acinar arteries in experimental pulmonary artery hypertension and outcomes of treatment].
The relative ratios of vessel lumen area/total area (EA/TA), vessel wall area/total area (MA/TA) and vessel wall thickness/vessel external diameter (WD/TD) of intra-acinar arteries were studied with image analysor in 35 rats of experimental pulmonary artery hypertension and outcomes of treatment. All the rats were divided into control group (R0), hypertension group (R1) and treated groups (R2), (R3) and (R4). The results showed relative ratios of EA/TA decreased significantly in the palmonary artery hypertension group in comparison with the control and treated groups, while the values of WA/TA and WD/TD increased significantly. The results may be valuable for morphological quantitative study, diagnosis of pulmonary artery hypertension and prediction of the disease prognosis.
Wang
B
B
Harbin Medical University.
Chui
S
S
Yang
B
B
Zhou
C
C
Ding
W
W
D000470:Alkaloids / Q000627:therapeutic use; D000498:Allyl Compounds; D000818:Animals; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D044182:Benzylisoquinolines; D004220:Disulfides / Q000627:therapeutic use*; D006976:Hypertension, Pulmonary / Q000188:drug therapy / Q000473:pathology*; D007091:Image Processing, Computer-Assisted; D011651:Pulmonary Artery / Q000473:pathology*; D011719:Pyrazines / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar
D000470:Alkaloids; D000498:Allyl Compounds; D000959:Antihypertensive Agents; D044182:Benzylisoquinolines; D004220:Disulfides; D011719:Pyrazines; C028009:diallyl disulfide; C027870:berbamine; C017953:tetramethylpyrazine