Do sodium nitroprusside and L-NAME affect pyrogen fever in rabbits?
Thermoregulatory responses after treatment with nitric oxide (NO) donor, sodium nitroprusside (SNP-3 mg/kg/h), or NO synthase inhibitor, NG-nitro-L-arginine methylester (L-NAME-100 mg/kg) were investigated in febrile rabbits (lipopolysaccharide E. coli-1 meg/kg). Pretreatment with SNP attenuated pyrogen fever as well as metabolic rate. L-NAME also inhibited postpyrogen increases in metabolism; however, this effect did not lead to antipyresis.
Gagało
I T
IT
Department of Pharmacology, Medical University of Gdansk, Poland.
Hać
E E
EE
Korolkiewicz
K Z
KZ
Matuszek
M T
MT
Szreder
Z
Z
D018712:Analgesics, Non-Narcotic / Q000494:pharmacology*; D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005260:Female; D005334:Fever / Q000139:chemically induced*; D008297:Male; D019331:NG-Nitroarginine Methyl Ester / Q000494:pharmacology*; D009599:Nitroprusside / Q000494:pharmacology*; D011749:Pyrogens; D011817:Rabbits
D018712:Analgesics, Non-Narcotic; D004791:Enzyme Inhibitors; D011749:Pyrogens; D009599:Nitroprusside; D019331:NG-Nitroarginine Methyl Ester