[Microscopic identification of melanoma metastases in occult primary tumor].
A case of the metastasis of the tumor with a high degree of anaplasia to the neck lymph nodes is described. Histological features of the neoplasm--a combination of the epithelial-like and fusiform cells, alveolar and individual character of their surrounding by the argyrophil fibers and the presence of fine argyrophil granules in Paskal silvering--allowed to suspect the metastasis of pigment-free malignant melanoma, and to select a small panel of antibodies for immunohistochemical analysis. The expression by the tumor cells of vimentin, S-100 protein and melanoma antigen proved this tumor to be a malignant melanoma metastasis. Location of the primary tumor has not been revealed.
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D000328:Adult; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008207:Lymphatic Metastasis; D008545:Melanoma / Q000737:chemistry / Q000473:pathology* / Q000556:secondary; D009382:Neoplasms, Unknown Primary / Q000737:chemistry / Q000473:pathology*