title: Isolated cerebral aspergilloma--long-term survival of a renal transplant recipient.
abstract: A renal transplant recipient with isolated cerebral aspergilloma 4 months after allograft transplantation is reported. On admission cerebral computed tomography showed a ring-enhancing mass in the left frontal hemisphere and aspirated purulent material revealed A. fumigatus hyphae. He was cured by short-term antifungal therapy and neurosurgical removal of the well demarcated lesion. He is still alive more than two years later and the renal transplant is well functioning. This is the first report of a renal transplant recipient with isolated cerebral aspergillosis without any relapse and only the third patient who has survived longer than 3 months. Early diagnostic procedures with rapid confirmation of aspergillus infection are pivotal for a benign clinical course.
authors.affiliation: Department of Internal Medicine and Nephrology, Rheinisch-Westfalisch Technical University RWTH of Aachen, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Mrowka
authors.forename: B
authors.initials: B
authors.lastname: Heintz
authors.forename: J
authors.initials: J
authors.lastname: Weis
authors.forename: L
authors.initials: L
authors.lastname: Mayfrank
authors.forename: J
authors.initials: J
authors.lastname: Reul
authors.forename: H G
authors.initials: HG
authors.lastname: Sieberth
mesh_terms: D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D001228:Aspergillosis / Q000401:mortality / Q000628:therapy*; D001232:Aspergillus fumigatus; D001927:Brain Diseases / Q000382:microbiology* / Q000401:mortality / Q000628:therapy; D003131:Combined Modality Therapy; D003399:Craniotomy; D004322:Drainage; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007676:Kidney Failure, Chronic / Q000601:surgery; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged
chemical_list: D000935:Antifungal Agents; D007166:Immunosuppressive Agents; D000666:Amphotericin B