title: Cytomegalovirus and simian immunodeficiency virus coinfection: longitudinal study of antibody responses and disease progression.
abstract: Antibody titers to rhesus cytomegalovirus (RhCMV) were prospectively analyzed over a period of 68 weeks in a longitudinal serosurvey of 17 RhCMV-seropositive rhesus macaques (Macaca mulatta) experimentally coinfected with simian immunodeficiency virus (SIV). These were compared with anti-RhCMV titers in 18 animals that were also naturally infected with RhCMV but not infected with SIV. Fluctuations in anti-RhCMV antibody titers were observed within 5 weeks of SIV inoculation, and two distinct patterns of RhCMV antibody response were observed in SIV-infected animals. Animals showing a progressive decline in anti-RhCMV immunoglobulin G (IgG) exhibited the most rapid disease progression, coincident with low anti-SIV and anti-tetanus toxoid IgG responses, high levels of p27 antigen in the plasma, and short survival. Animals exhibiting a more stable CMV-specific response after SIV inoculation had the least rapid disease course. Anti-RhCMV antibody titers in SIV-uninfected animals remained relatively stable during the period of study. Evidence that preinoculation immunologic measures predicted postinoculation outcome was equivocal.
authors.affiliation: California Regional Primate Research Center, University of California, Davis 95616-8542, USA.
authors.forename: S
authors.initials: S
authors.lastname: Baroncelli
authors.forename: P A
authors.initials: PA
authors.lastname: Barry
authors.forename: J P
authors.initials: JP
authors.lastname: Capitanio
authors.forename: N W
authors.initials: NW
authors.lastname: Lerche
authors.forename: M
authors.initials: M
authors.lastname: Otsyula
authors.forename: S P
authors.initials: SP
authors.lastname: Mendoza
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000097:blood*; D018791:CD4 Lymphocyte Count; D003586:Cytomegalovirus Infections / Q000150:complications / Q000276:immunology* / Q000473:pathology; D004797:Enzyme-Linked Immunosorbent Assay; D007074:Immunoglobulin G / Q000097:blood; D008253:Macaca mulatta; D008297:Male; D016097:Simian Acquired Immunodeficiency Syndrome / Q000150:complications / Q000276:immunology* / Q000473:pathology; D013745:Tetanus Toxoid / Q000276:immunology
chemical_list: D000914:Antibodies, Viral; D007074:Immunoglobulin G; D013745:Tetanus Toxoid