[Mediator aspects of the inflammatory process].
Signal sequences of inflammation and regeneration are presented. The number of factors such as sensor neuropeptides, lipid mediators, interleukins and factors of growth are shown to participate in the initiation and regulation of inflammation. These factors are produced in a certain sequence by various structures: cells-object of damage, opsonocytophagic and immune cells, connective tissue cells. This results in the stimulation of adhesion proteins, processes of migration, chemotaxis, interaction with components of the intercellular matrix and parenchyma cells of the viscera. Fibroblast is considered to be the central figure in the resolution of inflammation and its chronization. The regulation of the process occurs with the help of autocrine regulation and apoptosis of functionally exhausted cells.
Shubich
M G
MG
Abdeeva
M G
MG
D017209:Apoptosis / Q000502:physiology; D005347:Fibroblasts / Q000502:physiology; D006133:Growth Substances / Q000502:physiology; D006801:Humans; D018836:Inflammation Mediators; D007378:Interleukins / Q000502:physiology; D008055:Lipids / Q000502:physiology; D009479:Neuropeptides / Q000502:physiology; D012038:Regeneration / Q000502:physiology*
D006133:Growth Substances; D018836:Inflammation Mediators; D007378:Interleukins; D008055:Lipids; D009479:Neuropeptides