title: Pathogenesis and prevention of HTLV-1-associated diseases.
abstract: HTLV-1 is an important factor involved in various diseases including adult T-cell leukemia/lymphoma and HTLV-1 associated myelopathy/tropical spastic paraparesis. Amount of HTLV-1 provirus integrated in human peripheral blood mononuclear cells might be a candidate for a risk factor in the manifestation of HTLV-1 associated diseases. Experimental animal models would be useful to dissect the pathogenesis of HTLV-1 associated diseases. We present rat and mouse models of HTLV-1 infection. Using these animal models, we could clarify the intrauterine transmission of HTLV-1, and have found that both genetic background and HTLV-1 infection are important in pathogenesis of HAM/TSP-like rats. We also discuss the preventive measures of HTLV-1 transmission by use of antisense oligonucleotides.
authors.affiliation: Department of Biochemistry and Molecular Oncology, University of Tsukuba, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Miwa
authors.forename: S
authors.initials: S
authors.lastname: Kushida
authors.forename: N
authors.initials: N
authors.lastname: Maeda
authors.forename: J
authors.initials: J
authors.lastname: Fang
authors.forename: T
authors.initials: T
authors.lastname: Kawamura
authors.forename: T
authors.initials: T
authors.lastname: Kameyama
authors.forename: K
authors.initials: K
authors.lastname: Uchida
mesh_terms: D000328:Adult; D000818:Animals; D001782:Blood Donors; D002353:Carrier State; D015490:HTLV-I Infections / Q000453:epidemiology* / Q000517:prevention & control* / Q000635:transmission; D000882:Haplorhini; D015368:Human T-lymphotropic virus 1 / Q000302:isolation & purification*; D006801:Humans; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000453:epidemiology* / Q000517:prevention & control / Q000635:transmission; D051379:Mice; D015493:Paraparesis, Tropical Spastic / Q000453:epidemiology* / Q000517:prevention & control / Q000635:transmission; D011533:Proviruses / Q000302:isolation & purification; D011817:Rabbits; D051381:Rats; D012307:Risk Factors