4-hydroxynonenal-induced relaxation of human mesenteric arteries.
The effect of 4-hydroxynonenal (4-HNE), a circulating lipid peroxidation product, on the vascular tone of human mesenteric arteries is studied. 4-HNE promotes relaxation of human mesenteric arterial rings in a concentration-dependent manner. Removal of the endothelium or treatment with N(G)-nitro-L-arginine methyl ester hydrochloride (L-NAME; 10(-4) M) partially prevented 4-HNE-induced relaxation, thus suggesting the intervention of nitric oxide from endothelial origin in the vascular effects of 4-HNE.
Romero
F J
FJ
Department of Physiology, School of Medicine & Dentistry, University of Valencia, Spain.
Romero
M J
MJ
Bosch-Morell
F
F
Martínez
M C
MC
Medina
P
P
Lluch
S
S
D000328:Adult; D000368:Aged; D000447:Aldehydes / Q000494:pharmacology*; D004730:Endothelium, Vascular / Q000502:physiology*; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D066298:In Vitro Techniques; D015227:Lipid Peroxidation / Q000502:physiology; D008297:Male; D008638:Mesenteric Arteries / Q000187:drug effects* / Q000502:physiology; D008875:Middle Aged; D009119:Muscle Contraction / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects* / Q000502:physiology; D019331:NG-Nitroarginine Methyl Ester / Q000494:pharmacology; D009569:Nitric Oxide / Q000494:pharmacology; D009638:Norepinephrine / Q000494:pharmacology; D014664:Vasodilation / Q000187:drug effects*
D000447:Aldehydes; D009569:Nitric Oxide; C027576:4-hydroxy-2-nonenal; D019331:NG-Nitroarginine Methyl Ester; D009638:Norepinephrine