No effect of the alpha1-antichymotrypsin A allele in Alzheimer's disease.
The apolipoprotein E (ApoE)-epsilon4 allele is associated in a dose dependent manner to an increased risk for Alzheimer's disease. However, the ApoE-epsilon4 allele effect does not account for all patients with Alzheimer's disease, and the existence of other genetic risk factors has been postulated. Kamboh et al reported an association between Alzheimer's disease and the A allele of alpha1-antichymotrypsin (Aact) gene, which was not confirmed in a larger series more recently analysed. The ApoE and Aact genotypes were analysed in 314 patients with Alzheimer's disease and 173 healthy controls, confirming the dose dependent effect of the ApoE-epsilon4 allele. Nevertheless, even using odds ratios adjusted for age and sex, there was no significant effect of the Aact genotype on Alzheimer's disease or on the ApoE-epsilon4 allele associated risk for Alzheimer's disease.
Didierjean
O
O
INSERM U 289, Hôpital de la Salpêtrière, Paris, France.
Martinez
M
M
Campion
D
D
Hannequin
D
D
Dubois
B
B
Martin
C
C
Puel
M
M
Thomas Anterion
C
C
Pasquier
F
F
Moreau
O
O
Babron
M C
MC
Penet
C
C
Agid
Y
Y
Clerget-Darpoux
F
F
Frebourg
T
T
Brice
A
A
D000483:Alleles; D000544:Alzheimer Disease / Q000235:genetics*; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008957:Models, Genetic; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D012044:Regression Analysis; D012307:Risk Factors; D000514:alpha 1-Antichymotrypsin / Q000235:genetics*
D053327:Apolipoprotein E4; D001057:Apolipoproteins E; D000514:alpha 1-Antichymotrypsin