title: Activated protein C resistance can be associated with recurrent fetal loss.
abstract: As thrombosis of placental vessels may result in recurrent fetal loss, we analysed 39 consecutive women with recurrent fetal loss of unknown cause for activated protein C resistance. Factor V Leiden (FVL) mutation (19 cases) or APC resistance without FVL (nine cases) were found among these 39 women. Evaluation of 128 pregnancies in 19 patients with factor V Leiden mutation and 56 gestations in nine women with acquired APC resistance, revealed over 50% first-trimester abortions and 17% late abortions. Intra-uterine fetal death occurred in nine out of 19 FVL patients (47%). Only 34 of 184 gestations (18%) in hereditary or acquired APC-resistance women resulted in a live birth, with 11 of the 34 (32%) being premature deliveries. These data suggest that, in some patients with recurrent fetal loss, hereditary and acquired APC resistance are potential causes of vascular placental insufficiency.
authors.affiliation: Thrombosis and Haemostasis Unit, Rambam Medical Centre, Bruce Rappaport Faculty of Medicine, Haifa, Israel.
authors.forename: B
authors.initials: B
authors.lastname: Brenner
authors.forename: H
authors.initials: H
authors.lastname: Mandel
authors.forename: N
authors.initials: N
authors.lastname: Lanir
authors.forename: J
authors.initials: J
authors.lastname: Younis
authors.forename: H
authors.initials: H
authors.lastname: Rothbart
authors.forename: G
authors.initials: G
authors.lastname: Ohel
authors.forename: Z
authors.initials: Z
authors.lastname: Blumenfeld
mesh_terms: D000026:Abortion, Habitual / Q000097:blood / Q000209:etiology* / Q000235:genetics; D000328:Adult; D005165:Factor V / Q000235:genetics*; D005260:Female; D006579:Heterozygote; D006801:Humans; D008875:Middle Aged; D009154:Mutation; D010920:Placenta / Q000098:blood supply*; D016133:Polymerase Chain Reaction; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000097:blood / Q000209:etiology*; D020151:Protein C Deficiency; D013927:Thrombosis / Q000209:etiology* / Q000235:genetics
chemical_list: C095381:factor V Leiden; D005165:Factor V