The effects of own fetal growth on reported hypertension in parous women aged 33.
BACKGROUND
Data from the study of the British 1958 birth cohort, National Child Development Study (NCDS), has allowed wider investigation of the relationship between retarded fetal growth and risk of adult hypertension.


METHODS
A history of self-reported hypertension was related to fetal growth in 3308 parous cohort members. Fetal growth, the measure used, is the difference in actual birthweight from that expected for the gestational age and subsequent adult height. The relationships were investigated both linearly and non-linearly adjusting for potential confounders.


RESULTS
After adjustment for confounding factors, including adult weight for height, retarded fetal growth was associated with reported hypertension particularly when not confined to pregnancy. The latter was also associated with accelerated fetal growth, moderate or severe hypertension in the mother when pregnant with the cohort member, being relatively taller than your mother, and lack of educational qualifications. Hypertension confined to pregnancy was more likely among women who were themselves firstborn or older at childbirth. Neither maternal smoking during cohort's gestation nor cohort member's gestational age had a significant effect. The results are consistent with previous reports that fetal growth effects are less marked if gestation is short.


CONCLUSIONS
The relationships between fetal growth and subsequent hypertension are extremely complex and variable, and need to be studied allowing for deviations from growth potential. Adult weight for height remains the strongest predictor of hypertension. The results suggest that losing weight is likely to have the same proportional benefit in women with and without a history of retarded fetal growth.
Hennessy
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Department of Environmental and Preventive Medicine, The Wolfson Institute of Preventive Medicine. St. Bartholomew's, London, UK.
Alberman
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D000328:Adult; D001827:Body Height; D001835:Body Weight; D016009:Chi-Square Distribution; D015331:Cohort Studies; D016001:Confidence Intervals; D005260:Female; D005317:Fetal Growth Retardation / Q000453:epidemiology*; D006306:Health Surveys; D006801:Humans; D006973:Hypertension / Q000453:epidemiology*; D016017:Odds Ratio; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000453:epidemiology*; D012044:Regression Analysis; D017584:Reproductive History; D012189:Retrospective Studies; D012307:Risk Factors; D006113:United Kingdom / Q000453:epidemiology