Bone morphogenetic proteins: background and implications for oral reconstruction. A review.
For over 30 years now, research has been carried out to isolate and purify bone morphogenetic protein (BMP), a substance which has been shown to induce heterotopic bone formation in various animal species. Recent advances in the fields of developmental biology, molecular biology, genetics and wound healing, have shown that the BMPs are not only responsible for postfetal bone induction (including normal bone remodeling, healing and repair), but are also critical during embryogenesis, not only in regards to the skeletal system, but quite possibly in the morphogenesis and pattern formation of other tissues and organs as well. Therefore, BMPs have the potential as a therapeutic utility in orthopedic and dento-alveolar reconstruction.
Lee
M B
MB
Department of Periodontics, Loma Linda University, School of Dentistry, CA 92350, USA.
D000818:Animals; D001695:Biology; D001847:Bone Diseases / Q000628:therapy; D019485:Bone Morphogenetic Proteins / Q000235:genetics / Q000302:isolation & purification / Q000494:pharmacology / Q000502:physiology*; D001861:Bone Regeneration / Q000502:physiology; D016723:Bone Remodeling / Q000502:physiology; D001842:Bone and Bones / Q000196:embryology; D002828:Choristoma; D005314:Embryonic and Fetal Development; D006801:Humans; D007571:Jaw Diseases / Q000628:therapy; D008967:Molecular Biology; D009024:Morphogenesis / Q000502:physiology; D009059:Mouth Diseases / Q000628:therapy; D009999:Ossification, Heterotopic / Q000139:chemically induced; D010012:Osteogenesis / Q000502:physiology; D014945:Wound Healing
D019485:Bone Morphogenetic Proteins