Effects of cardiac autonomic imbalance on postnatal changes in the electrocardiographic Q-T interval in conscious swine.
The effects of partial autonomic denervation of the heart rate and Q--T interval were examined during maturation in swine. Four groups of newborns were prepared: right stellate ganglionectomy (RSG), left stellate ganglionectomy (LSG), right cardiac vagotomy (RCV) and sham-operated. Swine were studied postsurgically for eight weeks. Unexpected deaths of unknown cause occurred in five of the 20 denervated swine but in none of the 10 sham-operated controls. Prolongation of the Q--T interval was greatest in RSG animals and least in RCV as compared to controls. The results indicate that we have successfully developed an animal model of a long Q--T syndrome in swine.
Tong
S
S
Department of Physiology, SUNY Health Science Center at Brooklyn 11203, USA.
Ingenito
S
S
Frasier
I D
ID
Sica
A L
AL
Gootman
N
N
Gootman
P M
PM
D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D001341:Autonomic Nervous System / Q000502:physiology*; D004562:Electrocardiography; D005260:Female; D015171:Ganglionectomy; D006329:Heart Conduction System / Q000502:physiology*; D006339:Heart Rate; D008297:Male; D013233:Stellate Ganglion / Q000502:physiology; D013552:Swine; D014628:Vagotomy; D014630:Vagus Nerve / Q000502:physiology