title: Growth-regulating influence of nonactivated resident macrophages on transformed and tumor cells in the in vitro contact interactions.
abstract: Susceptibility to cytostatic activity of nonactivated macrophages (Mph) of Syrian hamster embryo fibroblasts (HEF) transformed in vitro by BAV-3, SV40, RSV-SR, or spontaneously and of their in vivo selected variants was studied in dynamics (5 days of co-incubation). With the use of 3H-TdR incorporation test it was demonstrated that HEF transformed by BAV-3 appeared to be able to overcome the cytostasis at 4-5 day of the co-incubation with Mph, in contrast to deeply suppressed spontaneously transformed cells of STHE strain. HEF transformed by SV40, or RSV-SR appeared to be resistant to growth-inhibiting activity of Mph during almost all the 5-day period. The in vivo selected malignant variants of STHE cells were able to recover from cytostasis after 4-5 days of the co-incubation with nonactivated Mph, in contrast to low-malignant variant and to parental cell strain.
authors.affiliation: Institute of Carcinogenesis, Cancer Research Center, Academy of Medical Sciences, Moscow, Russia.
authors.forename: L G
authors.initials: LG
authors.lastname: Burdelya
mesh_terms: D000818:Animals; D002450:Cell Communication; D002461:Cell Line, Transformed / Q000502:physiology; D002470:Cell Survival / Q000502:physiology*; D002471:Cell Transformation, Neoplastic / Q000378:metabolism*; D002472:Cell Transformation, Viral; D018920:Coculture Techniques; D006224:Cricetinae; D005347:Fibroblasts; D017737:Macrophages, Peritoneal / Q000502:physiology*; D008647:Mesocricetus