title: (S)-(+)-4-[7-(2,2-dimethyl-1-oxopropoxy)-4-methyl-2-[4-[2-(1-piperidinyl)-ethoxy]phenyl]-2H-1-benzopyran-3-yl]-phenyl 2,2-dimethylpropanoate (EM-800): a highly potent, specific, and orally active nonsteroidal antiestrogen.
authors.affiliation: Laboratory of Molecular Endocrinology, CHUL Research Centre, Le Centre Hospitalier Universitaire de Québec, Canada.
authors.forename: S
authors.initials: S
authors.lastname: Gauthier
authors.forename: B
authors.initials: B
authors.lastname: Caron
authors.forename: J
authors.initials: J
authors.lastname: Cloutier
authors.forename: Y L
authors.initials: YL
authors.lastname: Dory
authors.forename: A
authors.initials: A
authors.lastname: Favre
authors.forename: D
authors.initials: D
authors.lastname: Larouche
authors.forename: J
authors.initials: J
authors.lastname: Mailhot
authors.forename: C
authors.initials: C
authors.lastname: Ouellet
authors.forename: A
authors.initials: A
authors.lastname: Schwerdtfeger
authors.forename: G
authors.initials: G
authors.lastname: Leblanc
authors.forename: C
authors.initials: C
authors.lastname: Martel
authors.forename: J
authors.initials: J
authors.lastname: Simard
authors.forename: Y
authors.initials: Y
authors.lastname: Mérand
authors.forename: A
authors.initials: A
authors.lastname: Bélanger
authors.forename: C
authors.initials: C
authors.lastname: Labrie
authors.forename: F
authors.initials: F
authors.lastname: Labrie
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001578:Benzopyrans / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001667:Binding, Competitive; D001943:Breast Neoplasms / Q000378:metabolism*; D003600:Cytosol / Q000378:metabolism; D004054:Diethylstilbestrol / Q000378:metabolism; D004958:Estradiol / Q000378:metabolism; D004965:Estrogen Antagonists / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D005260:Female; D006801:Humans; D051379:Mice; D015394:Molecular Structure; D010052:Ovariectomy; D010880:Piperidines / Q000737:chemistry; D011422:Propionates / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D020849:Raloxifene Hydrochloride; D011960:Receptors, Estrogen / Q000378:metabolism*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D014599:Uterus / Q000187:drug effects / Q000378:metabolism*
chemical_list: D001578:Benzopyrans; D004965:Estrogen Antagonists; D010880:Piperidines; D011422:Propionates; D011960:Receptors, Estrogen; D020849:Raloxifene Hydrochloride; D004958:Estradiol; D004054:Diethylstilbestrol; C106945:EM 800