The acylation stimulating protein pathway: clinical implications.
OBJECTIVE
The present review will focus particularly on acylation stimulating protein (ASP) and its role in adipose tissue. Two issues will be addressed (1) in vitro biochemical characterization of ASP in cell culture studies, and (2) in vivo clinical relevance for normal physiology and in pathological conditions.


CONCLUSIONS
Fat is In! There can be no question that in recent years fat tissue has become recognized as more than just a passive storage site. It is a metabolically active tissue that, under normal conditions, allows the efficient clearance of triglyceride and glucose for storage as energy. Under abnormal conditions, adipose tissue dysfunction is associated with obesity, diabetes and coronary heart disease. Adipose tissue function may be controlled by many factors.
Cianflone
K
K
McGill Unit for the Prevention of Cardiovascular Disease, McGill University, Montreal, Quebec, Canada.
D017667:Adipocytes / Q000378:metabolism; D000273:Adipose Tissue / Q000502:physiology; D000818:Animals; D001692:Biological Transport / Q000502:physiology; D001798:Blood Proteins / Q000502:physiology*; D015926:Complement C3a / Q000031:analogs & derivatives*; D011416:Complement Factor D; D004951:Esterification; D005227:Fatty Acids / Q000378:metabolism*; D006801:Humans; D012697:Serine Endopeptidases / Q000502:physiology; D014280:Triglycerides / Q000096:biosynthesis / Q000378:metabolism*
D001798:Blood Proteins; D005227:Fatty Acids; D014280:Triglycerides; C044541:complement C3a, des-Arg-(77)-; D015926:Complement C3a; D012697:Serine Endopeptidases; C493488:CFD protein, human; D011416:Complement Factor D