Modulation of hormone-dependent transcriptional activity of the glucocorticoid receptor by the tumor suppressor p53.
The glucocorticoid receptor (GR) is a ligand-dependent transcription factor which regulates growth, development and metabolic functions. To test the hypothesis that the pleiotropic effect of the GR could be mediated by other transcription factors/oncogenes, the present study assessed its interaction with the tumor suppressor p53. p53 is a transcription factor which is involved in cell cycle regulation and apoptosis. We found that the wild-type p53 physically interacted with the GR and repressed the glucocorticoid-dependent transcriptional activity. In contrast, mutant p53 had no or a lesser effect depending on the type of p53 mutant. These findings raised the possibility that p53 may play an important role in modulating the activities of glucocorticoids in cells.
Yu
C
C
Division of Basic Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4255, USA.
Yap
N
N
Chen
D
D
Cheng
S
S
D002453:Cell Cycle; D005938:Glucocorticoids / Q000502:physiology*; D006801:Humans; D011965:Receptors, Glucocorticoid / Q000502:physiology*; D014157:Transcription Factors / Q000502:physiology*; D016159:Tumor Suppressor Protein p53 / Q000502:physiology*
D005938:Glucocorticoids; D011965:Receptors, Glucocorticoid; D014157:Transcription Factors; D016159:Tumor Suppressor Protein p53