title: Impaired specific immunoreactivity in cows with hepatic lipidosis.
abstract: In this study, hepatic lipidosis in cows was experimentally induced by offering an energy surplus during the dry period. Liver triacylglycerol (TAG) was 16% in the experimental group. In the control group fed the same diet in restricted quantities, liver TAG was about 7%. The animals of both groups were vaccinated with tetanus vaccine at Day 3 after parturition. It was demonstrated that the cows with high liver TAG percentages had lower humoral and cellular (P < 0.05) immunological responses compared with the animals with low liver TAG levels at Day 14 after vaccination. The results obtained in the high TAG group support the notion that the frequent occurrence of aspecific infections in cows with hepatic lipidosis may be due to impaired immunoreactivity.
authors.affiliation: Department of Large Animal Medicine and Nutrition, Veterinary Faculty, Utrecht University, The Netherlands.
authors.forename: G H
authors.initials: GH
authors.lastname: Wentink
authors.forename: V P
authors.initials: VP
authors.lastname: Rutten
authors.forename: T S
authors.initials: TS
authors.lastname: van den Ingh
authors.forename: A
authors.initials: A
authors.lastname: Hoek
authors.forename: K E
authors.initials: KE
authors.lastname: Müller
authors.forename: T
authors.initials: T
authors.lastname: Wensing
mesh_terms: D000818:Animals; D000907:Antibodies, Bacterial / Q000096:biosynthesis*; D000918:Antibody Specificity; D002417:Cattle; D002418:Cattle Diseases / Q000276:immunology*; D002478:Cells, Cultured; D005260:Female; D008064:Lipidoses / Q000097:blood / Q000276:immunology* / Q000662:veterinary*; D008107:Liver Diseases / Q000097:blood / Q000276:immunology* / Q000662:veterinary*; D008213:Lymphocyte Activation; D011247:Pregnancy; D013745:Tetanus Toxoid / Q000276:immunology
chemical_list: D000907:Antibodies, Bacterial; D013745:Tetanus Toxoid