Cytokines: shared receptors, distinct functions.
That the signal transduction pathways used by the cytokines IL-2 and IL-15 are identical would suggest that these cytokines have redundant roles in lymphoid development; instead, IL-2 is the guardian of thymus-derived T-cell homeostasis, while interleukin-15 promotes extrathymic development of T and NK cells.
DiSanto
J P
JP
INSERM U429, Hôpital Necker-Enfants Malades, F-75743, Paris, France.
D000818:Animals; D004268:DNA-Binding Proteins / Q000378:metabolism; D006801:Humans; D019409:Interleukin-15 / Q000378:metabolism*; D007376:Interleukin-2 / Q000378:metabolism*; D053613:Janus Kinase 1; D053616:Janus Kinase 3; D007694:Killer Cells, Natural / Q000166:cytology* / Q000378:metabolism; D008894:Milk Proteins; D011505:Protein-Tyrosine Kinases / Q000378:metabolism; D018121:Receptors, Cytokine / Q000378:metabolism; D015375:Receptors, Interleukin-2 / Q000378:metabolism; D050796:STAT3 Transcription Factor; D050799:STAT5 Transcription Factor; D013601:T-Lymphocytes / Q000166:cytology* / Q000378:metabolism; D015534:Trans-Activators / Q000378:metabolism
D004268:DNA-Binding Proteins; D019409:Interleukin-15; D007376:Interleukin-2; D008894:Milk Proteins; D018121:Receptors, Cytokine; D015375:Receptors, Interleukin-2; D050796:STAT3 Transcription Factor; C494086:STAT3 protein, human; D050799:STAT5 Transcription Factor; D015534:Trans-Activators; D011505:Protein-Tyrosine Kinases; C507904:JAK1 protein, human; C507933:JAK3 protein, human; D053613:Janus Kinase 1; D053616:Janus Kinase 3