Role of interleukin 8 in the pathogenesis of proliferative vitreoretinopathy.
We investigated the role of interleukin 8 (IL-8) in the pathogenesis of proliferative vitreoretinopathy (PVR). The IL-8 level in the vitreous and the blood of 20 patients with PVR was measured by a specific enzyme-linked immunoassay method. Vitreous from cadaver eyes (n = 20) was used as the control. The IL-8 level in the vitreous was between 31.3 and 65 pg/ml in 40% of eyes with PVR. IL-8 was detected neither in the blood of the patients with PVR nor in the vitreous from cadaver eyes. IL-8 levels in the vitreous did not correlate with either the grade of PVR or the duration of symptoms. These results suggest that IL-8 may play a role in the pathogenesis of PVR.
Aksünger
A
A
Department of Ophthalmology, Gazi University Medical School, Ankara, Turkey.
Or
M
M
Okur
H
H
Hasanreisoğlu
B
B
Akbatur
H
H
D000328:Adult; D002102:Cadaver; D005260:Female; D006801:Humans; D016209:Interleukin-8 / Q000378:metabolism / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D018630:Vitreoretinopathy, Proliferative / Q000209:etiology* / Q000378:metabolism / Q000503:physiopathology; D014822:Vitreous Body / Q000378:metabolism
D016209:Interleukin-8