[A double column double pH solid phase extraction and capillary GC/FID method for rapid simultaneous determination of acidic and basic drugs in human plasma].
A capillary gas chromatographic method for the rapid simultaneous identification and quantitation of acidic and basic drugs in human plasma is presented. A special double column solid phase extraction device was designed, in which two X-5 resin columns can extract drugs at different pH. The detection limits for acidic and basic drugs can reach 0.5 microgram.ml-1, while the time needed is only half of that when using commercial solid phase extraction cartridges.
Qiu
F H
FH
Institute of Toxicology and Pharmacology, Academy of Military Medical Sciences, Beijing.
Liu
L
L
Luo
Y
Y
Lu
Y Q
YQ
D000779:Anesthetics, Local / Q000097:blood; D014150:Antipsychotic Agents / Q000097:blood*; D002849:Chromatography, Gas / Q000379:methods; D003975:Diazepam / Q000097:blood; D006801:Humans; D006993:Hypnotics and Sedatives / Q000097:blood*; D008012:Lidocaine / Q000097:blood; D010640:Phenothiazines; D012631:Secobarbital / Q000097:blood*
D000779:Anesthetics, Local; D014150:Antipsychotic Agents; D006993:Hypnotics and Sedatives; D010640:Phenothiazines; D012631:Secobarbital; D008012:Lidocaine; D003975:Diazepam