Colonic adenocarcinoma in a rhesus macaque (Macaca mulatta).
A spontaneous colonic adenocarcinoma and endometriosis was diagnosed in a 34-year-old female rhesus macaque (Macaca mulatta). The tumor caused partial obstruction of the ascending colon and histologically resembled the commonly described napkin-ring tumors of the descending and sigmoid colon found in humans. Serum levels of CA 125, a high-molecular-weight glycoprotein antigen that has been reported elevated in a variety of pathological conditions of the pelvic cavity in humans, was severely elevated. Both the adenocarcinoma and the endometriosis may have contributed to this finding.
Johnson
E H
EH
Section of Comparative Medicine, Yale University School of Medicine, New Haven, CT, USA.
Morgenstern
S E
SE
Perham
J M
JM
Barthold
S W
SW
D000230:Adenocarcinoma / Q000150:complications / Q000473:pathology / Q000662:veterinary*; D000818:Animals; D002272:Carcinoembryonic Antigen / Q000097:blood; D003110:Colonic Neoplasms / Q000150:complications / Q000473:pathology / Q000662:veterinary*; D004715:Endometriosis / Q000097:blood / Q000150:complications / Q000473:pathology / Q000628:therapy / Q000662:veterinary; D005260:Female; D006801:Humans; D007044:Hysterectomy / Q000662:veterinary; D016729:Leuprolide / Q000627:therapeutic use; D008253:Macaca mulatta; D018419:Primate Diseases
D002272:Carcinoembryonic Antigen; D016729:Leuprolide