title: Regulation of angiogenesis by hypoxic stress: from solid tumours to the ovarian follicle.
abstract: The preovulatory follicle provides a unique physiological example of rapid growth accompanied by neovascularization, two processes that are generally characteristic of pathologies such as wound repair or malignancy. During the hours preceding ovulation, follicular growth is accompanied by elevated levels of messenger RNA for vascular endothelial growth factor (VEGF). Angiogenic activity, mediated by VEGF, is manifested in the peripheral blood vessels surrounding the follicle, that show capillary sprouting and increased vascular permeability. Following ovulation, rapid infiltration of capillaries through the follicular wall is essential for the formation of the corpus luteum. In this review we compare the preovulatory follicle with a popular model of avascular solid tumour growth, namely the multicellular tumour spheroid, in particular the role of hypoxic stress in the regulation of angiogenesis in both systems.
authors.affiliation: Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel.
authors.forename: M
authors.initials: M
authors.lastname: Neeman
authors.forename: R
authors.initials: R
authors.lastname: Abramovitch
authors.forename: Y S
authors.initials: YS
authors.lastname: Schiffenbauer
authors.forename: C
authors.initials: C
authors.lastname: Tempel
mesh_terms: D015687:Cell Hypoxia / Q000502:physiology*; D016228:Endothelial Growth Factors / Q000502:physiology*; D005260:Female; D006801:Humans; D008222:Lymphokines / Q000502:physiology*; D008597:Menstrual Cycle / Q000502:physiology; D018977:Micronutrients / Q000378:metabolism; D009369:Neoplasms / Q000098:blood supply*; D009389:Neovascularization, Pathologic / Q000209:etiology / Q000503:physiopathology*; D018919:Neovascularization, Physiologic / Q000502:physiology*; D006080:Ovarian Follicle / Q000098:blood supply*; D018874:Spheroids, Cellular / Q000473:pathology; D013312:Stress, Physiological / Q000503:physiopathology; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors
chemical_list: D016228:Endothelial Growth Factors; D008222:Lymphokines; D018977:Micronutrients; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors