[Rhinovirus infection and expression of adhesion molecules in human tracheal epithelium].
Rhinovirus infection has attracted attention because it can lead to acute exacerbations of chronic inflammatory airway diseases such as bronchial asthma and chronic bronchitis. We established a culture system and inoculated human rhinovirus to human tracheal epithelial cells, and found that infection was augmented by up-regulation of intercellular adhesion molecule-1, which is the receptor for this virus. We also found that human airway epithelial cells infected with rhinovirus were susceptible to a chemical oxidant (H2O2) released by inflammatory cells, which would contribute to acute exacerbations of inflammatory airway diseases. Finally, we found that anti-ICAM-1 antibodies or dexamethasone can inhibit the infectivity to rhinovirus by suppressing ICAM-1, and diminish susceptibility to oxidants in the cultured human tracheal epithelium.
Ohrui
T
T
Department of Geriatric Medicine, Tohoku University School of Medicine, Sendai, Japan.
Yamaya
M
M
Sekizawa
K
K
Terajima
M
M
Yamada
N
N
Suzuki
T
T
Okinaga
S
S
Hoshi
H
H
Suzuki
H
H
Sasaki
H
H
D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D002478:Cells, Cultured; D016207:Cytokines / Q000494:pharmacology / Q000502:physiology; D003907:Dexamethasone / Q000494:pharmacology; D004848:Epithelium / Q000821:virology; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000378:metabolism*; D016877:Oxidants / Q000378:metabolism; D012229:Rhinovirus / Q000502:physiology*; D014132:Trachea / Q000378:metabolism / Q000821:virology*; D014779:Virus Replication / Q000187:drug effects
D000893:Anti-Inflammatory Agents; D016207:Cytokines; D016877:Oxidants; D018799:Intercellular Adhesion Molecule-1; D003907:Dexamethasone