Effects of oophorectomy on interstitial fluid pressure, blood flow and vascularity in a rat mammary tumour.
Interstitial fluid pressure (IFP), tumour size, blood flow and vascularity were measured in dimethyl-benz-alpha-anthracene-induced rat mammary tumours after oophorectomy. IFP was measured in the tumours by the wick-in-needle technique, blood flow by the labelled microsphere technique and vascularity by fluorescence vascular staining. Tumour volume was determined by measuring two diameters. Oophorectomy resulted in a decrease in tumour volume preceded by a decrease in IFP, while no significant change was observed in total tumour blood flow. The vascular cross-sectional area seemed to decrease. Cell proliferation may be of importance for the high interstitial fluid pressure in this hormone dependent tumour. A reduced metabolic requirement in the regressing tissue, down-regulating the vascular capacity, may camouflage the influence of the reduced tissue pressure on blood perfusion.
Hultborn
R
R
Department of Oncology, University of Göteborg, Sweden.
Tveit
E
E
Angerås
M
M
Köpf
I
I
Weiss
L
L
D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D005110:Extracellular Space / Q000502:physiology; D005260:Female; D008325:Mammary Neoplasms, Experimental / Q000098:blood supply* / Q000139:chemically induced / Q000503:physiopathology*; D008863:Microspheres; D010052:Ovariectomy; D011312:Pressure; D051381:Rats; D017207:Rats, Sprague-Dawley; D012039:Regional Blood Flow
D015127:9,10-Dimethyl-1,2-benzanthracene