Diffuse pulmonary amyloidosis with monoclonal IgG-kappa gammopathy.
A 62-year-old female with diffuse pulmonary amyloidosis developed abnormal radiographic findings while under observation for hyperimmunoglobulinemia over a ten-year period. Serum immunoglobulin G (IgG) was elevated (4,620 mg/dl), and associated with monoclonal gammopathy (M protein) of the kappa type, but no evident abnormalities were apparent in bone marrow. Chest radiograph and computed tomography showed a diffuse reticulonodular shadow in the bilateral lung. Thoracoscopic lung biopsy specimen revealed depositions of amyloid in the bronchus and pulmonary vessel. We emphasize that diffuse pulmonary amyloidosis should be considered a possible diagnosis in the presence of monoclonal immunoglobulin.
Takashi
S
S
First Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto.
Koizumi
T
T
Yamazaki
Y
Y
Hayasaka
M
M
Kubo
K
K
Sekiguchi
M
M
Honda
T
T
D000686:Amyloidosis / Q000150:complications* / Q000175:diagnosis; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D007145:Immunoglobulin kappa-Chains / Q000097:blood*; D008171:Lung Diseases / Q000150:complications* / Q000175:diagnosis; D008875:Middle Aged; D010265:Paraproteinemias / Q000150:complications* / Q000276:immunology
D007074:Immunoglobulin G; D007145:Immunoglobulin kappa-Chains