title: Phase II study of pyrazoloacridine in patients with advanced colorectal carcinoma.
abstract: OBJECTIVE
  Pyrazoloacridine (PZA) is an acridine derivative selected for clinical development because of broad preclinical antitumor activity and solid tumor selectivity. Phase I evaluations with PZA have demonstrated predictable toxicity and suggested clinical efficacy. A phase II trial in patients with previously untreated advanced colorectal cancer was conducted.
  
  
  METHODS
  PZA was administered at a dose of 750 mg/m2 intravenously over 3 h every 21 days to patients who received a total of 31 courses of PZA.
  
  
  RESULTS
  In 15 patients evaluable for response, no responses were observed (0% response rate, 95% confidence interval 0-22%). Toxicity to PZA consisted of myelosuppression and neurotoxicity that was treatment-limiting in several instances.
  
  
  CONCLUSIONS
  PZA at this dose and schedule of administration is inactive in patients with colorectal cancer.
authors.affiliation: Karmanos Cancer Institute, Department of Medicine, Wayne State University, Detroit, MI 48201, USA.
authors.forename: M M
authors.initials: MM
authors.lastname: Zalupski
authors.forename: P A
authors.initials: PA
authors.lastname: Philip
authors.forename: P
authors.initials: P
authors.lastname: LoRusso
authors.forename: A F
authors.initials: AF
authors.lastname: Shields
mesh_terms: D000166:Acridines / Q000009:adverse effects / Q000627:therapeutic use*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D002277:Carcinoma / Q000188:drug therapy* / Q000556:secondary; D015179:Colorectal Neoplasms / Q000188:drug therapy*; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007970:Leukopenia / Q000139:chemically induced; D008297:Male; D008875:Middle Aged; D011720:Pyrazoles / Q000009:adverse effects / Q000627:therapeutic use*; D012449:Safety; D016896:Treatment Outcome
chemical_list: D000166:Acridines; D000970:Antineoplastic Agents; D011720:Pyrazoles