title: Hypoxia-induced ABR change and heat shock protein expression in the pontine auditory pathway of young rabbits.
abstract: The auditory brainstem response (ABR) was compared with the immunohistochemical expression of heat shock protein (HSP-72) and microtubule-associated protein 2 (MAP-2) of the brainstem auditory pathway in young rabbits subjected to hypoxic stress. Severe hypoxia for 2 h produced significant prolongation and decreased amplitude of the later component of ABR. HSP-72 expression was distinctly increased in the cochlear nucleus, but there was less induction in the inferior colliculus under severe hypoxia. MAP-2 immunostaining of neuropiles in the inferior collicular nucleus was decreased slightly after severe-long hypoxia, but cytoplasmic staining did not change. The present ABR change, which was produced by brainstem hypoxia-ischemia and acidosis, may be due to the neural cytoarchitectural derangement and less induction of stress proteins in the upper brainstem.
authors.affiliation: National Institute of Mental Health, National Center of Neurology and Psychiatry (NCNP), Ichikawa, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Inagaki
authors.forename: M
authors.initials: M
authors.lastname: Kaga
authors.forename: H
authors.initials: H
authors.lastname: Isumi
authors.forename: S
authors.initials: S
authors.lastname: Hirano
authors.forename: S
authors.initials: S
authors.lastname: Takashima
authors.forename: E
authors.initials: E
authors.lastname: Nanba
mesh_terms: D000818:Animals; D001306:Auditory Pathways / Q000502:physiology* / Q000503:physiopathology; D001639:Bicarbonates / Q000097:blood; D001794:Blood Pressure; D002245:Carbon Dioxide / Q000097:blood; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D005260:Female; D050884:HSP72 Heat-Shock Proteins; D006339:Heart Rate; D006360:Heat-Shock Proteins / Q000096:biosynthesis*; D000860:Hypoxia; D007150:Immunohistochemistry; D008869:Microtubule-Associated Proteins / Q000096:biosynthesis; D009928:Organ Specificity; D010100:Oxygen / Q000097:blood; D010313:Partial Pressure; D011149:Pons / Q000502:physiology* / Q000503:physiopathology; D011817:Rabbits
chemical_list: D001639:Bicarbonates; D050884:HSP72 Heat-Shock Proteins; D006360:Heat-Shock Proteins; D008869:Microtubule-Associated Proteins; D002245:Carbon Dioxide; D010100:Oxygen