To be or not to be a T-lymphomas, that is determined by a dominant gene Tlsm-1 in mouse models.
A single dominant gene Tlsm-1 was found to determine the type of spontaneous lymphomas to be T in the cross between AKR/Ms and SL/Kh. Microsatellite analysis mapped Tlsm-1 at the position 61 cM from centromere of Chr. 7. Study of this segment of T-lymphoma prone AKXD Rl strains also showed association of Tlsm-1 with T-lymphomas. On the other hand, lymphoma latency was significantly shorten by a recessive gene lla of SL/Kh. By a quantitative trait analysis, lla was located in class II gene in MHC.
Hiai
H
H
Dept. Pathology and Biology of Diseases, Kyoto Univ. Graduate school of Medicine, Japan.
Yamada
Y
Y
Shisa
H
H
Kamoto
T
T
Abujiang
P
P
Lu
L M
LM
D000818:Animals; D002503:Centromere; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D004198:Disease Susceptibility; D005799:Genes, Dominant; D005802:Genes, MHC Class II; D005808:Genes, Recessive; D016399:Lymphoma, T-Cell / Q000145:classification / Q000235:genetics*; D051379:Mice; D008806:Mice, Inbred AKR; D008815:Mice, Inbred Strains; D009363:Neoplasm Proteins / Q000235:genetics*
D009363:Neoplasm Proteins