Chronic animal experiment with magnetically suspended centrifugal pump.
We have been developing a new type of centrifugal pump for long-term use. The magnetically suspended centrifugal pump (MSCP) contains no shaft and seal so that long life expectancy is predicted. Paracorporeal left ventricular (LV) assist circulation between the left atrium and the descending aorta was instituted using sheep. The flow rates ranged from 2.5-5.5 L/min. The sheep that lived the longest (46 days) died of an embolism as a result of the thrombus in the pump. No thrombus formation was observed in other pumps. Plasma free hemoglobin levels ranged from 9 to 18 mg/dl, which led to the conclusion that the hemolysis level remained within an acceptable range. Two driving modes were compared. The slope of the pressure-flow relationship plot under a constant motor current mode was steeper than that under a constant rotational speed mode, and thus, the flow fluctuation decreased. In conclusion, the MSCP is durable for more than a month at the current stage of development and is a promising device for long-term ventricular assist.
Yamada
T
T
Department of Cardiovascular Surgery, Kyoto University, Japan.
Nishimura
K
K
Park
C H
CH
Kono
S
S
Yuasa
S
S
Tsukiya
T
T
Akamatsu
T
T
Matsuda
K
K
Ban
T
T
D000818:Animals; D000925:Anticoagulants / Q000627:therapeutic use; D001011:Aorta / Q000473:pathology / Q000502:physiology; D016275:Atrial Function; D001783:Blood Flow Velocity / Q000502:physiology; D002407:Catheterization, Swan-Ganz; D002498:Centrifugation; D004389:Durable Medical Equipment; D004574:Electromagnetic Fields; D006353:Heart-Assist Devices / Q000009:adverse effects / Q000592:standards / Q000639:trends; D006439:Hemodynamics / Q000502:physiology; D006454:Hemoglobins / Q000378:metabolism; D006461:Hemolysis; D006493:Heparin / Q000627:therapeutic use; D011673:Pulsatile Flow; D012756:Sheep; D013923:Thromboembolism / Q000401:mortality / Q000517:prevention & control; D016277:Ventricular Function, Left / Q000502:physiology
D000925:Anticoagulants; D006454:Hemoglobins; D006493:Heparin