Fixed low-dose combination of an angiotensin converting enzyme inhibitor and a calcium channel blocker drug in the treatment of essential hypertension.
OBJECTIVE
To review the possibilities of combination treatment in hypertension with special emphasis on the combination of an angiotensin converting enzyme (ACE) inhibitor and a calcium channel blocker.


RESULTS
An increasing number of combination of drugs has become available. Fixed combinations, often low-dose, have proved suitable for the treatment of hypertension, even as first-line therapy.


CONCLUSIONS
A fixed combination of an ACE inhibitor and a calcium channel blocker, in particular the combination of trandolapril and verapamil, is a suitable alternative to existing treatment modalities.
de Leeuw
P W
PW
Department of Medicine, University Hospital Maastricht, The Netherlands.
Kroon
A A
AA
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000008:administration & dosage*; D002121:Calcium Channel Blockers / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*
D000806:Angiotensin-Converting Enzyme Inhibitors; D002121:Calcium Channel Blockers