Induction of interleukin-1 and interleukin-1 receptor antagonist.
Drugs that affect the production or action, or both, of the pleiotropic inflammatory cytokine interleukin-1 (IL-1) are predicted to have a significant impact on a variety of human diseases. The biochemical properties of IL-1 and the IL-1 receptor antagonist, the mechanism for their production, and the factors that regulate their release are discussed here. The association of IL-1 with various disease states is also reviewed. Various classes of drugs that can be used to manipulate the production of IL-1 and IL- I receptor antagonist are described. Interferon-alpha2b is a potent inhibitor in vitro of the induction of IL-1 and tumor necrosis factor by IL-1 and can induce high circulating levels of the anti-inflammatory soluble tumor necrosis factor receptor and IL-1 receptor antagonist in humans. Thus, interferon-alpha2b exhibits potent anti-inflammatory effects.
Dinarello
C A
CA
Department of Medicine, University of Colorado Health Science Center, Denver 80262, USA.
D004194:Disease; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000494:pharmacology*; D053590:Interleukin 1 Receptor Antagonist Protein; D007375:Interleukin-1 / Q000037:antagonists & inhibitors / Q000096:biosynthesis* / Q000235:genetics; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D011994:Recombinant Proteins; D012795:Sialoglycoproteins / Q000037:antagonists & inhibitors / Q000096:biosynthesis*
C507763:IL1RN protein, human; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D053590:Interleukin 1 Receptor Antagonist Protein; D007375:Interleukin-1; D012333:RNA, Messenger; D011994:Recombinant Proteins; D012795:Sialoglycoproteins