(S)-(+)-4-[7-(2,2-dimethyl-1-oxopropoxy)-4-methyl-2-[4-[2-(1-piperidinyl)-ethoxy]phenyl]-2H-1-benzopyran-3-yl]-phenyl 2,2-dimethylpropanoate (EM-800): a highly potent, specific, and orally active nonsteroidal antiestrogen.
Gauthier
S
S
Laboratory of Molecular Endocrinology, CHUL Research Centre, Le Centre Hospitalier Universitaire de Québec, Canada.
Caron
B
B
Cloutier
J
J
Dory
Y L
YL
Favre
A
A
Larouche
D
D
Mailhot
J
J
Ouellet
C
C
Schwerdtfeger
A
A
Leblanc
G
G
Martel
C
C
Simard
J
J
Mérand
Y
Y
Bélanger
A
A
Labrie
C
C
Labrie
F
F
D000284:Administration, Oral; D000818:Animals; D001578:Benzopyrans / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001667:Binding, Competitive; D001943:Breast Neoplasms / Q000378:metabolism*; D003600:Cytosol / Q000378:metabolism; D004054:Diethylstilbestrol / Q000378:metabolism; D004958:Estradiol / Q000378:metabolism; D004965:Estrogen Antagonists / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D005260:Female; D006801:Humans; D051379:Mice; D015394:Molecular Structure; D010052:Ovariectomy; D010880:Piperidines / Q000737:chemistry; D011422:Propionates / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D020849:Raloxifene Hydrochloride; D011960:Receptors, Estrogen / Q000378:metabolism*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D014599:Uterus / Q000187:drug effects / Q000378:metabolism*
D001578:Benzopyrans; D004965:Estrogen Antagonists; D010880:Piperidines; D011422:Propionates; D011960:Receptors, Estrogen; D020849:Raloxifene Hydrochloride; D004958:Estradiol; D004054:Diethylstilbestrol; C106945:EM 800