Long-lasting treatment with adenosine receptor antagonists: effects on hypoxic tolerance and vascular responsiveness.
In electrically driven myocardial preparations obtained from chronically methylxanthine-[aminophylline (APH) and 8-phenyltheophylline (8-PT)] or solvent(DMSO)-treated guinea pigs no differences were found in alteration of mechanical activity under hypoxia and reoxygenation. The vasoconstrictor effects observed after in vitro exposure of pulmonary arterial preparations (excised from either methylxanthine- or solvent-treated guinea pigs) to both noradrenaline and PGF2 alpha were also similar. In methylxanthine-treated vascular tissues, however, nitroglycerin and NO exerted more pronounced vasorelaxant effect than in specimens prepared from solvent-treated guinea pigs.
Cseppentö
A
A
Department of Pharmacology, University Medical School of Debrecen, Hungary.
Ujfalusi
A
A
Antal
K
K
Szegi
J
J
Szabó
J Z
JZ
Kovács
P
P
Szentmiklósi
A J
AJ
D000628:Aminophylline / Q000494:pharmacology; D000818:Animals; D016275:Atrial Function / Q000187:drug effects; D002316:Cardiotonic Agents / Q000494:pharmacology; D015237:Dinoprost / Q000494:pharmacology; D005260:Female; D006168:Guinea Pigs; D000860:Hypoxia / Q000503:physiopathology*; D066298:In Vitro Techniques; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D009569:Nitric Oxide / Q000494:pharmacology; D009638:Norepinephrine / Q000494:pharmacology; D011651:Pulmonary Artery / Q000187:drug effects / Q000503:physiopathology; D058915:Purinergic P1 Receptor Antagonists; D013806:Theophylline / Q000031:analogs & derivatives / Q000494:pharmacology; D013997:Time Factors; D014661:Vasoconstriction
D002316:Cardiotonic Agents; D058915:Purinergic P1 Receptor Antagonists; D000628:Aminophylline; D009569:Nitric Oxide; D015237:Dinoprost; D013806:Theophylline; C028322:8-phenyltheophylline; D009638:Norepinephrine