Construction of a standard reference for PET studies of methionine accumulation using a computerised brain atlas.
Positron emission tomography (PET) is valuable for assessing the biochemistry and physiology of the human brain. A computerised brain atlas has been developed which allows demonstration of anatomical regions of PET images and manipulation of these images into a standardised anatomical space. Once the images are in this standardised three-dimensional space it is possible to make comparisons between individuals and groups of individuals. We describe the use of this atlas in the generation of a set of mean reference images using methionine PET images of normal volunteers.
Romanowski
C A
CA
Department of Clinical Neuroscience, Karolinska Hospital, Stockholm, Sweden.
Leslie
D F
DF
Thurfjell
L
L
Ericson
K
K
Stone-Elander
S
S
D000328:Adult; D001921:Brain / Q000033:anatomy & histology / Q000000981:diagnostic imaging*; D001931:Brain Mapping / Q000295:instrumentation*; D002250:Carbon Radioisotopes; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000295:instrumentation*; D008279:Magnetic Resonance Imaging / Q000295:instrumentation; D008297:Male; D008715:Methionine / Q000031:analogs & derivatives; D012016:Reference Values; D014055:Tomography, Emission-Computed / Q000295:instrumentation*
D002250:Carbon Radioisotopes; D008715:Methionine; C038344:methionine methyl ester