title: Vesico-ureteric reflux in adult patients with spinal injury.
abstract: OBJECTIVE
  To review the incidence, aetiology, treatment and prognosis of vesico-ureteric reflux (VUR) in patients in a regional spinal injuries centre.
  
  
  METHODS
  A retrospective review of radiological investigations revealed 34 of 447 (8%) patients with VUR on at least one study. The notes of these patients were examined to determine their management and outcome.
  
  
  RESULTS
  Most patients developed VUR within 4 years of injury; the underlying intravesical pressure was high in half the patients studied. Patients were managed aggressively with a variety of medical and surgical techniques. The VUR of 15 patients resolved completely and in three patients there was some improvement. Renal function deteriorated in three patients as assessed by isotopic scanning. Two patients were transferred to our unit in end-stage renal failure associated with VUR and died within one year.
  
  
  CONCLUSIONS
  VUR continues to be a problem in patients with spinal injury and remains potentially fatal through the effects of high transmitted pressure and infection. Renal failure does not always develop as a consequence of the combination of VUR and high intravesical pressure. No single aetiological factor for VUR was found. With active early treatment, the incidence of VUR can be minimized and long-term complications avoided.
authors.affiliation: Spinal Injuries Unit, Royal National Orthopaedic Hospital Trust, Stanmore, UK.
authors.forename: S J
authors.initials: SJ
authors.lastname: Foley
authors.forename: J P
authors.initials: JP
authors.lastname: McFarlane
authors.forename: P J
authors.initials: PJ
authors.lastname: Shah
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013124:Spinal Injuries / Q000150:complications*; D016896:Treatment Outcome; D001750:Urinary Bladder, Neurogenic / Q000209:etiology / Q000628:therapy; D014718:Vesico-Ureteral Reflux / Q000453:epidemiology / Q000209:etiology* / Q000628:therapy