title: tap, a Drosophila bHLH gene expressed in chemosensory organs.
abstract: We have isolated a Drosophila bHLH gene, tap, that is expressed in a small subset of neurons when they undergo differentiation. In the peripheral nervous system, tap is expressed exclusively in one of the neurons that innervate each larval chemosensory organ, possibly controlling the specific properties of that neuron. Sequence comparisons suggest that tap is most closely related to two bHLH genes identified in several vertebrate species, neurogenin and neuroD, which are involved respectively in neural determination and in neuronal differentiation.
authors.affiliation: Laboratoire de Neurobiologie, Université Libre de Bruxelles, Rhode-Saint-Genèse, Belgium.
authors.forename: P
authors.initials: P
authors.lastname: Gautier
authors.forename: V
authors.initials: V
authors.lastname: Ledent
authors.forename: M
authors.initials: M
authors.lastname: Massaer
authors.forename: C
authors.initials: C
authors.lastname: Dambly-Chaudière
authors.forename: A
authors.initials: A
authors.lastname: Ghysen
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002107:Caenorhabditis; D029742:Caenorhabditis elegans Proteins; D018076:DNA, Complementary; D004330:Drosophila / Q000235:genetics; D029721:Drosophila Proteins; D018507:Gene Expression Regulation, Developmental; D018257:Helix-Loop-Helix Motifs; D015801:Helminth Proteins / Q000737:chemistry; D019476:Insect Proteins / Q000737:chemistry / Q000235:genetics*; D060850:LIM-Homeodomain Proteins; D051379:Mice; D008807:Mice, Inbred BALB C; D008969:Molecular Sequence Data; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism; D009474:Neurons / Q000378:metabolism; D009479:Neuropeptides / Q000737:chemistry / Q000235:genetics*; D051761:Paired Box Transcription Factors; D012679:Sense Organs / Q000378:metabolism; D017422:Sequence Analysis, DNA; D017386:Sequence Homology, Amino Acid; D014157:Transcription Factors
chemical_list: D029742:Caenorhabditis elegans Proteins; D018076:DNA, Complementary; D029721:Drosophila Proteins; D015801:Helminth Proteins; D019476:Insect Proteins; D060850:LIM-Homeodomain Proteins; D009419:Nerve Tissue Proteins; D009479:Neuropeptides; D051761:Paired Box Transcription Factors; C073863:Poxn protein, Drosophila; C107036:Tap protein, Drosophila; D014157:Transcription Factors; C072005:mec-3 protein, C elegans