title: [A quinapril-hydrochlorothiazide combination in the treatment of essential arterial hypertension].
abstract: This open, non-controlled study was planned to investigate efficacy and tolerability of fixed combination quinapril 20 mg plus hydrochlorothiazide 12.5 mg for treatment of mild-to-moderate essential hypertension. One hundred and fifty seven patients, with diastolic pressure ranging 105-119 mmHg, were enrolled after two weeks wash-out; during this period patients received placebo. After placebo phase, patients received one tablet/day of fixed combination for six weeks: at the end of this period patients were classified as "responder" (lowering of pressure = or > 10 mmHg) or "non responder"; "non responder" were planned to receive two tablets/day while "responder" maintained the former posology. Patients were reexamined after four weeks: "non responder" were dropped out while "responder" maintained the actual posology. Study was performed in fourteen weeks totally; at the end of this period fourteen patients were classified as "non responder". The fixed combination quinapril 20 mg plus hydrochlorothiazide 12.5 mg can be considered a valid drug for the treatment of mild-to-moderate hypertension.
authors.affiliation: Sviluppo Clinico, Recordati SpA, Milano.
authors.forename: P
authors.initials: P
authors.lastname: Dominici
authors.forename: R
authors.initials: R
authors.lastname: Cosentina
mesh_terms: D000959:Antihypertensive Agents / Q000627:therapeutic use*; D004338:Drug Combinations; D005260:Female; D006801:Humans; D006852:Hydrochlorothiazide / Q000627:therapeutic use*; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D007546:Isoquinolines / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D000077583:Quinapril; D044005:Tetrahydroisoquinolines
chemical_list: D000959:Antihypertensive Agents; D004338:Drug Combinations; D007546:Isoquinolines; D044005:Tetrahydroisoquinolines; D006852:Hydrochlorothiazide; D000077583:Quinapril