An analysis of the intracerebral ability to eliminate a nitroxide radical in the rat after administration of idebenone by an in vivo rapid scan electron spin resonance spectrometer.
Electron spin resonance (ESR) measurements after intracerebroventricular injection of a nitroxide radical were carried out in rats (n = 6) that received oral idebenone for 2 weeks and in control rats (n = 5), using an in vivo rapid scan ESR spectrometer. The half-life of nitroxide, which was estimated from the change in the peak height (delta M = +1) of the ESR signals from the head, was used as a marker for the elimination of the nitroxide radical. The half-life in the rats treated with idebenone was significantly shorter than it was in the controls (p < 0.05). This finding indicates that the treatment with idebenone can enhance the intracerebral-eliminating ability of the nitroxide radical.
Yokoyama
H
H
Institute for Life Support Technology, Yamagata Technopolis Foundation, Japan.
Tsuchihashi
N
N
Ogata
T
T
Hiramatsu
M
M
Mori
N
N
D000818:Animals; D016227:Benzoquinones / Q000008:administration & dosage / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects* / Q000378:metabolism*; D003497:Cyclic N-Oxides / Q000008:administration & dosage / Q000493:pharmacokinetics; D004578:Electron Spin Resonance Spectroscopy / Q000379:methods*; D005609:Free Radicals / Q000008:administration & dosage / Q000493:pharmacokinetics; D006207:Half-Life; D007276:Injections, Intraventricular; D008297:Male; D009589:Nitrogen Oxides / Q000008:administration & dosage / Q000493:pharmacokinetics*; D011759:Pyrrolidines / Q000008:administration & dosage / Q000493:pharmacokinetics; D051381:Rats; D017208:Rats, Wistar; D014451:Ubiquinone / Q000031:analogs & derivatives
D016227:Benzoquinones; D003497:Cyclic N-Oxides; D005609:Free Radicals; D009589:Nitrogen Oxides; D011759:Pyrrolidines; D014451:Ubiquinone; C077426:3-carbamoyl-2,2,5,5-tetramethyl-1-pyrrolidinyl-N-oxyl; C039900:nitroxyl; C036619:idebenone