Two new lignans with activity against influenza virus from the medicinal plant Rhinacanthus nasutus.
Two new lignans, rhinacanthin E (1) and rhinacanthin F (2), were isolated from the aerial parts of the plant Rhinacanthus nasutus. Their structures were established by detailed spectroscopic analysis. These compounds show significant antiviral activity against influenza virus type A.
Kernan
M R
MR
Shaman Pharmaceuticals, South San Francisco, California 94080-4812, USA. mkernan@shaman.com
Sendl
A
A
Chen
J L
JL
Jolad
S D
SD
Blanc
P
P
Murphy
J T
JT
Stoddart
C A
CA
Nanakorn
W
W
Balick
M J
MJ
Rozhon
E J
EJ
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D009980:Influenza A virus / Q000187:drug effects*; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet; D013785:Thailand; D010948:Viral Plaque Assay
D000972:Antineoplastic Agents, Phytogenic; D000998:Antiviral Agents; D017705:Lignans; C107781:rhinacanthin E; C107782:rhinacanthin F