Induction of gelatinase B and MCP-2 in baboons during sublethal and lethal bacteraemia.
Intravenous injection of sublethal or lethal doses of Escherichia coli in baboons resulted in increased serum levels of the matrix metalloprotease gelatinase B and the chemokine monocyte chemotactic protein 2 (MCP-2). In both animal models, gelatinase B appeared faster than MCP-2. After sublethal challenge, serum levels of gelatinase B and MCP-2 were found to be correlated, reaching peak levels between 2 and 4 h after bacterial challenge. After lethal challenge, however, MCP-2 tended to increase until 10 h. The kinetics of appearance suggest induction of release of gelatinase B and de novo synthesis and secretion of MCP-2, both by endotoxin.
Paemen
L
L
Rega Institute for Medical Research, University of Leuven, Belgium.
Jansen
P M
PM
Proost
P
P
Van Damme
J
J
Opdenakker
G
G
Hack
E
E
Taylor
F B
FB
D000818:Animals; D016470:Bacteremia / Q000201:enzymology* / Q000276:immunology*; D054412:Chemokine CCL8; D017364:Collagenases / Q000096:biosynthesis* / Q000097:blood; D004195:Disease Models, Animal; D004731:Endotoxins / Q000633:toxicity; D004790:Enzyme Induction; D004927:Escherichia coli Infections / Q000201:enzymology* / Q000276:immunology*; D007700:Kinetics; D020780:Matrix Metalloproteinase 9; D018945:Monocyte Chemoattractant Proteins / Q000096:biosynthesis* / Q000097:blood; D010215:Papio
D054412:Chemokine CCL8; D004731:Endotoxins; D018945:Monocyte Chemoattractant Proteins; D017364:Collagenases; D020780:Matrix Metalloproteinase 9