title: Prognosis of gastric carcinoma with emphasis on lymph node status.
abstract: A retrospective study of surgical treatment for 123 patients with primary gastric carcinoma was made. Tumour-stage, presence of distant organ metastases, lymph node involvement, depth of wall-penetration and curative resection were the important prognostic criteria. Five-year survival rate was 22.8% in the whole series and 37.5% after curative (R0 M0) resection (p = 0.0029). Seventy-two patients (58.5%), i.e. 47 without (N0) and 25 with lymph node metastases (N1 + N2), underwent, R0-resection. The overall recurrence rate was significantly lower (4% vs. 36%; p = 0.004) and the 5-year survival rate higher (46% vs. 28%; p = 0.007) for the R0-N0-group than for the R0-N1 + N2-group. Distant organ metastases-related mortality was similar in these two groups of patients (51% vs. 60%; p = 0.7).
  
  
  CONCLUSIONS
  The poor prognosis of gastric carcinoma indicates the need for improved surgical technique and/or adjuvant therapy, but the necessity for adjuvant therapy without having performed D2 gastrectomy does not seem founded.
authors.affiliation: Department of Gastro-intestinal Surgery, Salvator-Ziekenhuis, Hasselt, Belgium.
authors.forename: B
authors.initials: B
authors.lastname: Topal
authors.forename: F
authors.initials: F
authors.lastname: Trimpeneers
authors.forename: J
authors.initials: J
authors.lastname: Hendrickx
mesh_terms: D000368:Aged; D005260:Female; D005743:Gastrectomy; D006801:Humans; D008197:Lymph Node Excision; D008207:Lymphatic Metastasis; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology; D009367:Neoplasm Staging; D010166:Palliative Care; D011379:Prognosis; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000401:mortality* / Q000473:pathology / Q000601:surgery*; D016019:Survival Analysis; D015996:Survival Rate; D013997:Time Factors