Changes in the biliary excretion of exogenous organic anions by streptozotocin-induced diabetes.
A transient depression of blood-glucose level was found after streptozotocin administration, which can be explained by insulin release due to the destroying effect of streptozotocin on beta-cells of pancreas, the biliary flow was elevated, when blood sugar level was low. After the transient decrease the blood glucose level was elevated and remained in a diabetic range (300-500 mg/100 ml). During the diabetic period a biphasic change was observed in the biliary flow: 23-48 hours after streptozotocin injection a depression, however, 5-10 days after streptozotocin administration an elevation was detected in the bile flow. Changes found in biliary excretion rate of exogenous organic anions were parallel with those of biliary flow.
Bojcsev
S
S
Deaprtment of Pharmacology, University Medical School, Pécs, Hungary.
Rafiei
A
A
Fischer
E
E
D000818:Animals; D000838:Anions / Q000378:metabolism*; D001646:Bile / Q000378:metabolism*; D001786:Blood Glucose / Q000032:analysis; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D000838:Anions; D001786:Blood Glucose