title: The effect of hollow-fiber dialyzer Plivadial Altra-Flux 140 on beta-2-microglobulin removal.
abstract: A thirty-fold or even greater increase in plasma beta-2-microglobulin (beta 2M), which is commonly found in end-stage renal disease (ESRD) patients on long-term hemodialysis (HD), is most likely a consequence of the inability of the dialysis procedure to remove the dally production of beta 2M. In the present study, a newly developed high-flux membrane composed of cellulose diacetate (CDA) (dialyzer Plivadial Altra-Flux 140, Pliva, Zagreb, Croatia) was evaluated with regard to beta 2M removal capacity during HD in 8 stable ESRD patients. Thera was a drop in the plasma beta 2M concentration (-19.8 +/- 8.4) with a clearance of 22.7 +/- 9.2 ml/min (QB = 250 ml/min, QD = 600 ml/min). Accordingly, the sieving coefficient (SC) was found to be 0.37 +/- 0.1 at 60 min after the start of HD. The CDA membrane was able to remove 100.5 +/- 30 mg of beta 2M during a 4-hour HD session. This data demonstrate an increased percentage removal of beta 2M and significantly decreased postdialysis plasma concentrations of beta 2M which is a potential factor in the development of dialysis-related amyloidosis (DRA).
authors.affiliation: Department of Nephrology and Dialysis, Sestre Milosrdnice University Hospital, Zagreb, Croatia.
authors.forename: P
authors.initials: P
authors.lastname: Kes
authors.forename: A
authors.initials: A
authors.lastname: Zubcić
authors.forename: I
authors.initials: I
authors.lastname: Ratković-Gusić
authors.forename: M
authors.initials: M
authors.lastname: Prsa
authors.forename: S
authors.initials: S
authors.lastname: Sefer
mesh_terms: D000328:Adult; D002482:Cellulose / Q000031:analogs & derivatives; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000628:therapy; D008297:Male; D008567:Membranes, Artificial; D008875:Middle Aged; D006435:Renal Dialysis / Q000295:instrumentation*; D001613:beta 2-Microglobulin / Q000032:analysis*
chemical_list: D008567:Membranes, Artificial; D001613:beta 2-Microglobulin; D002482:Cellulose; C026170:cellulose diacetate