[Protective effect of ATP-MgCl2 on gut mucosa in burn rat].
In order to study the protective effect of ATP-MgCl2 on gut mucosal barrier function in trauma-induced stressed animal, full thickness burn of 30% total body surface area (TBSA) was produced in rats, and ATP-MgCl2 was injected intraperitoneally right after scald-injury. Malondialdehyde (MDA) contents of ileum mucosa were determined and morphological alteration in the ileum was observed under light microscope. The results showed that ileum mucosal MDA content increased significantly, accompanied by obvious morphological change, after the injury, whereas MDA content was maintained at the normal control level and pathological alteration in ileum tissue was abated after the use of ATP-MgCl2. It suggests that ATP-MgCl2 possesses a protective effect on gut mucosal barrier function of scald-injured rat, and the mechanism involved may be related to the inhibition of lipid peroxidation in gut mucosa.
Su
Y
Y
Department of Burn Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an.
Chen
B
B
Tang
C
C
D000255:Adenosine Triphosphate / Q000494:pharmacology*; D000818:Animals; D002056:Burns / Q000473:pathology*; D007082:Ileum / Q000378:metabolism / Q000473:pathology; D007413:Intestinal Mucosa / Q000378:metabolism / Q000473:pathology*; D015636:Magnesium Chloride / Q000494:pharmacology*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley
D015636:Magnesium Chloride; D008315:Malondialdehyde; D000255:Adenosine Triphosphate