Development of the undulation pump total artificial heart.
The undulation pump is a small size continuous flow displacement type blood pump that has been developed for an artificial heart. Using undulation pumps, 2 types of implantable total artificial hearts (TAHs), the undulation pump TAH (UPTAH) type 1 (UPTAH 1) and UPTAH type 2 (UPTAH 2) were developed. Both UPTAHs were designed to be small enough to implant into the chest of a goat, the experimental animal. UPTAH 1 could be reduced in size to 75 mm in diameter and 78 mm in length. The weight was 520 g. UPTAH 2 could be reduced in size to 75 mm in diameter and 80 mm in length. The weight was 650 g. UPTAH 2 could be tested in an animal experiment using an adult female goat weighing 52.3 kg. The UPTAH 2 could be implanted successfully into the goat's chest with a good fit. The goat stood after the surgery and extubation and survived for 3 h and 40 min; thus, the potential of the UPTAH for a practical implantable TAH was demonstrated.
Abe
Y
Y
Institute of Medical Electronics, Faculty of Medicine, University of Tokyo, Japan.
Chinzei
T
T
Isoyama
T
T
Ono
T
T
Mochizuki
S
S
Mabuchi
K
K
Baba
K
K
Matsuura
H
H
Sun
Y P
YP
Kouno
A
A
Atsumi
K
K
Fujimasa
I
I
Imachi
K
K
D000818:Animals; D001696:Biomechanical Phenomena; D001783:Blood Flow Velocity / Q000502:physiology; D001794:Blood Pressure / Q000502:physiology; D002302:Cardiac Output / Q000502:physiology; D004389:Durable Medical Equipment; D004869:Equipment Safety; D005260:Female; D006041:Goats; D006354:Heart, Artificial / Q000639:trends*; D008904:Miniaturization; D011140:Polyurethanes / Q000592:standards; D011652:Pulmonary Circulation / Q000502:physiology; D011669:Pulmonary Wedge Pressure / Q000502:physiology; D011786:Quality Control; D013927:Thrombosis / Q000517:prevention & control
D011140:Polyurethanes