[The role of the outer-membrane antigens of Yersinia pseudotuberculosis in the pathogenesis and diagnosis of pseudotuberculosis].
The degree of manifestation of the virulent properties of Y. pseudotuberculosis strains was found to be directly related to the concentration of protein with a mol. wt. of 103 kD (invasin), localized in the outer membrane and necessary for the realization of the process of the penetration of the infective agent into eukaryotic cells. Antiserum to INV-2-BSA, an active synthetic fragment of invasin, capable of detecting one antigenic band with a mol. wt. of 103 kD, was used for the creation of a diagnostic enzyme immunoassay system. The new variant of the diagnostic system was shown to be highly effective in the diagnosis of the disease at an early period.
Kuliashova
L B
LB
Tseneva
G Ia
GIa
Buĭnevich
Iu B
IuB
D018829:Adhesins, Bacterial; D000818:Animals; D000942:Antigens, Bacterial / Q000032:analysis / Q000276:immunology*; D000954:Antigens, Surface / Q000032:analysis / Q000276:immunology; D001425:Bacterial Outer Membrane Proteins / Q000032:analysis / Q000276:immunology*; D001426:Bacterial Proteins / Q000032:analysis / Q000276:immunology*; D002460:Cell Line; D002478:Cells, Cultured; D006168:Guinea Pigs; D006801:Humans; D007114:Immunization; D008970:Molecular Weight; D009154:Mutation / Q000276:immunology; D011817:Rabbits; D013997:Time Factors; D014774:Virulence / Q000276:immunology; D015011:Yersinia pseudotuberculosis / Q000276:immunology* / Q000472:pathogenicity*; D015012:Yersinia pseudotuberculosis Infections / Q000175:diagnosis* / Q000209:etiology*
D018829:Adhesins, Bacterial; D000942:Antigens, Bacterial; D000954:Antigens, Surface; D001425:Bacterial Outer Membrane Proteins; D001426:Bacterial Proteins; C053476:invasin, Yersinia