title: 3-D histo-radiographic comparison of surgical clearances of microcalcified lesions in breast localization biopsies.
abstract: There is controversy as to the value of the radiological or pathological estimation of surgical clearance of microcalcifying breast lesions. An important part of this issue has been addressed by coordinated three-dimensional radiographic and histological examination of a prospective consecutive series of 40 benign and malignant mammographically detected lesions in surgical breast biopsy specimens containing microcalcifications, including 20 cases of ductal carcinoma in situ. They were radiographed from four viewpoints by means of rotation in a radiolucent tetrahedral container. The planes of histological examination were then chosen to correspond to the radiographic view showing the minimum separation of the edge of the specimen and the outermost microcalcification. There was a close correlation (Spearman ranked) between the least tetrahedral radiographic distance and the corresponding histological distance separating the surgical margin of excision. There were, however, incompatible Wilcoxon signed ranking orders when comparing the least tetrahedral distance or the histological distance with all four single radiographic views, including the conventional specimen radiographic view. Two-dimensional specimen mammography and standardized histological examination are suboptimal and may thus have contributed to confusion as to the value of determining adequate surgical excision of ductal carcinoma in situ of the breast. Although labour-intensive, use of four-view radiography and choice of the appropriate plane of histological examination give a better correlation of the radiographic estimates of surgical clearance with histology than single-view specimen radiography and arbitrary histological sectioning.
authors.affiliation: Regional Breast Pathology Unit, University of Bristol, U.K.
authors.forename: J D
authors.initials: JD
authors.lastname: Davies
authors.forename: S
authors.initials: S
authors.lastname: Sharp
authors.forename: C N
authors.initials: CN
authors.lastname: Chinyama
authors.forename: J R
authors.initials: JR
authors.lastname: Farndon
authors.forename: S P
authors.initials: SP
authors.lastname: Bates
authors.forename: S M
authors.initials: SM
authors.lastname: Astley
mesh_terms: D001706:Biopsy; D001941:Breast Diseases / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery*; D002114:Calcinosis / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D008327:Mammography; D011446:Prospective Studies; D012680:Sensitivity and Specificity