title: Synthesis and hydrolysis of cyclic ADP-ribose by human leukocyte antigen CD38: inhibition of hydrolysis by ATP and physiological significance.
authors.affiliation: Department of Biochemistry, Tohoku University School of Medicine, Sendai, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Okamoto
authors.forename: S
authors.initials: S
authors.lastname: Takasawa
authors.forename: A
authors.initials: A
authors.lastname: Tohgo
authors.forename: K
authors.initials: K
authors.lastname: Nata
authors.forename: I
authors.initials: I
authors.lastname: Kato
authors.forename: N
authors.initials: N
authors.lastname: Noguchi
mesh_terms: D036541:ADP-ribosyl Cyclase; D051997:ADP-ribosyl Cyclase 1; D000246:Adenosine Diphosphate Ribose / Q000031:analogs & derivatives* / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000378:metabolism* / Q000494:pharmacology; D000818:Animals; D015703:Antigens, CD; D000943:Antigens, Differentiation / Q000187:drug effects / Q000235:genetics / Q000378:metabolism*; D001048:Aplysia / Q000235:genetics; D019556:COS Cells; D002851:Chromatography, High Pressure Liquid; D003001:Cloning, Molecular; D036563:Cyclic ADP-Ribose; D004791:Enzyme Inhibitors; D058851:GPI-Linked Proteins; D006801:Humans; D006868:Hydrolysis; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000378:metabolism*; D008562:Membrane Glycoproteins / Q000235:genetics / Q000378:metabolism; D009154:Mutation; D009699:N-Glycosyl Hydrolases / Q000187:drug effects / Q000235:genetics / Q000378:metabolism*; D009536:Niacinamide / Q000378:metabolism; D012333:RNA, Messenger / Q000032:analysis; D051381:Rats; D011994:Recombinant Proteins / Q000378:metabolism
chemical_list: D015703:Antigens, CD; D000943:Antigens, Differentiation; D004791:Enzyme Inhibitors; D058851:GPI-Linked Proteins; D007328:Insulin; D008562:Membrane Glycoproteins; D012333:RNA, Messenger; D011994:Recombinant Proteins; D036563:Cyclic ADP-Ribose; D000246:Adenosine Diphosphate Ribose; D009536:Niacinamide; D000255:Adenosine Triphosphate; D009699:N-Glycosyl Hydrolases; D036541:ADP-ribosyl Cyclase; C087521:ADP-ribosyl cyclase 2; C498154:CD38 protein, human; C498156:Cd38 protein, rat; D051997:ADP-ribosyl Cyclase 1