title: Drug interactions with the nonsedating antihistamines.
abstract: The nonsedating antihistamines are frequently prescribed agents. Well-documented drug-drug interactions with two of these agents, terfenadine and astemizole, may result in serious adverse effects, including death, when they are prescribed along with macrolide antibiotics and/or the antifungal agents itraconazole or ketoconazole. Fexofenadine and loratadine appear to be the least likely nonsedating antihistamines to interact with other medications and to result in a life-threatening interaction. This article reviews the known drug-drug interactions involving nonsedating antihistamines and provides a basis from which the clinician can predict potential interactions.
authors.affiliation: Latrobe Area Hospital, Pennsylvania, USA.
authors.forename: P W
authors.initials: PW
authors.lastname: Ament
authors.forename: A
authors.initials: A
authors.lastname: Paterson
mesh_terms: D003577:Cytochrome P-450 Enzyme System / Q000187:drug effects; D004347:Drug Interactions; D011307:Drug Prescriptions; D006634:Histamine H1 Antagonists / Q000008:administration & dosage / Q000009:adverse effects* / Q000191:economics; D006801:Humans
chemical_list: D006634:Histamine H1 Antagonists; D003577:Cytochrome P-450 Enzyme System