Neonatal serotonin depletion modifies development but not plasticity in rat barrel cortex.
Effects of serotonin depletion (induced by neonatal injection of 5,7-dihydroxytryptamine) upon dimensions of cortical barrels and their metabolic activation, and upon effects of neonatal vibrissectomy sparing row C, were examined in 1-month-old rats. Dimensions of row C barrels, and of [14C]2-deoxyglucose (2-DG) labelling in the cortex obtained after stimulation of the row C vibrissae, were measured. Serotonin depletion did not change dimensions of barrels, but reduced the extent of 2-DG labelling of cortical representation of the row C whiskers by 30%. Vibrissectomy sparing this row resulted in an expansion of the row C barrels and of 2-DG labelling in the barrel cortex that were similar in both control and serotonin-depleted rats.
Turlejski
K
K
Department of Neurophysiology, Nencki Institute of Experimental Biology, Warsaw, Poland.
Djavadian
R L
RL
Kossut
M
M
D015116:5,7-Dihydroxytryptamine / Q000494:pharmacology; D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D000963:Antimetabolites; D001345:Autoradiography; D002851:Chromatography, High Pressure Liquid; D003847:Deoxyglucose; D007091:Image Processing, Computer-Assisted; D007150:Immunohistochemistry; D009473:Neuronal Plasticity / Q000187:drug effects*; D051381:Rats; D012701:Serotonin / Q000502:physiology*; D018490:Serotonin Agents / Q000494:pharmacology; D013003:Somatosensory Cortex / Q000187:drug effects / Q000254:growth & development* / Q000502:physiology*; D014738:Vibrissae / Q000502:physiology*
D000963:Antimetabolites; D018490:Serotonin Agents; D015116:5,7-Dihydroxytryptamine; D012701:Serotonin; D003847:Deoxyglucose