title: Visualizing nucleic acids and their complexes using electron microscopy.
abstract: Microscopic visualization of nucleic acid-protein complexes provides a means of obtaining structural information that is difficult to obtain in any other way, and of verifying conclusions derived from other approaches. The polymorphic, flexible, and irregular nature of these complexes presents particular problems in their analysis.
authors.affiliation: Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill 27599-7295, USA. jdg@med.unc.edu
authors.forename: J D
authors.initials: JD
authors.lastname: Griffith
authors.forename: S
authors.initials: S
authors.lastname: Lee
authors.forename: Y H
authors.initials: YH
authors.lastname: Wang
mesh_terms: D004247:DNA / Q000737:chemistry / Q000378:metabolism; D005615:Freezing; D008854:Microscopy, Electron / Q000379:methods*; D008855:Microscopy, Electron, Scanning / Q000379:methods; D009690:Nucleic Acid Conformation; D009696:Nucleic Acids / Q000737:chemistry* / Q000378:metabolism*; D011506:Proteins / Q000737:chemistry
chemical_list: D009696:Nucleic Acids; D011506:Proteins; D004247:DNA