Identification of motor and sensory brain activities during unilateral finger movement: spatiotemporal source analysis of movement-associated magnetic fields.
We investigated the movement-related cortical fields (MRCFs) recorded by magnetoencephalography (MEG) to identify the motor and sensory brain activities at the instant of the unilateral finger movement using six normal subjects. We focused our investigation on the source analysis of the events tightly linked to movement onset, and we used brain electric source analysis (BESA) to model the sources generating MRCFs during the interval from 200 ms before to 150 ms after the movement onset. Four sources provided satisfactory solutions for MRCF activities in this interval. Sources 1 and 2, which were located in the pre-central regions in the hemisphere contralateral and ipsilateral to the moved finger, respectively, generated the readiness fields (RF), but source 1 was predominant just before movement onset. The motor field (MF), the peak of which was just after movement onset, was mainly generated by source 1. Sources 3 and 4 were located in the post-central regions in the hemisphere contralateral and ipsilateral to the moved finger, respectively. The first motor evoked field (MEF-I), the peak of which was about 80 ms after the movement, was mainly generated by source 3, but with the participation of sources 1, 2 and 4. The results indicated that the activities of both pre -and post-central regions in bilateral hemispheres were related to voluntary movements, although the predominant areas varied over time. This is the first noninvasive study to clarify the complex spatiotemporal activities relating movements in humans using a multi-channel MEG system.
Hoshiyama
M
M
Department of Integrative Physiology, National Institute for Physiological Sciences, Myodaiji, Okazaki, Japan.
Kakigi
R
R
Berg
P
P
Koyama
S
S
Kitamura
Y
Y
Shimojo
M
M
Watanabe
S
S
Nakamura
A
A
D000328:Adult; D004576:Electromyography; D005260:Female; D005385:Fingers / Q000294:innervation / Q000502:physiology*; D006801:Humans; D015225:Magnetoencephalography; D008297:Male; D009044:Motor Cortex / Q000502:physiology*; D009068:Movement / Q000502:physiology*; D013003:Somatosensory Cortex / Q000502:physiology*; D013997:Time Factors