Prevalence of anti-FVIII antibodies in severe haemophilia A patients with inversion of intron 22.
The aim of our study was to investigate whether haemophilia A patients with inversion of intron 22 are at high risk for non-inhibitory anti-FVIII antibodies development detected by ELISA. It is known that patients with severe forms of haemophilia A are more likely to develop anti-FVIII antibodies. The incidence of inhibitory anti-FVIII antibodies in patients with factor VIII gene inversion has been extensively evaluated, but if this defect has to be considered a predisposing factor is still debatable. Non-inhibitory anti-FVIII antibodies are attracting interest, due to the potential influence on FVIII half-life. Our data show that FVIII gene inversion was a major predisposing factor for anti-FVIII antibodies development.
Vianello
F
F
Institute of Medical Semeiotics, University of Padua Medical School, Padova, Italy.
Radossi
P
P
Tison
T
T
Dazzi
F
F
Tagariello
G
G
Davoli
P G
PG
Girolami
A
A
D000293:Adolescent; D000328:Adult; D000906:Antibodies / Q000032:analysis* / Q000235:genetics; D007446:Chromosome Inversion; D004797:Enzyme-Linked Immunosorbent Assay; D005169:Factor VIII / Q000235:genetics / Q000276:immunology*; D006467:Hemophilia A / Q000235:genetics / Q000276:immunology*; D006801:Humans; D007438:Introns / Q000276:immunology*; D008875:Middle Aged; D012307:Risk Factors
D000906:Antibodies; D005169:Factor VIII