Tubular PAH transport capacity in human kidney tissue and in renal cell carcinoma: correlation with various clinical and morphological parameters of the tumor.
In vitro accumulation of p-aminohippurate (PAH) was investigated in "intact" human renal cortical slices of normal kidney tissue and in tissue slices of renal cell carcinoma (RCC). The technique used was established in preliminary experiments on rat kidney tissue slices. In principle, the accumulation capacity is comparable in renal tissue slices of both species (slice to medium accumulation ratios between 4 and 8). In man sex differences in accumulation capacity do not exist. But, as shown in detail for rats, accumulation capacity drops with age. Tissue slices of RCC are unable to accumulate PAH actively; slice to medium ratio reaches about 1 and indicates passive PAH uptake only. Surprisingly, in tumors of stage pT1 PAH uptake is lowest. perhaps as a sign of PAH transport out of the cells. There is no difference between peripheral and central parts of RCC. Age and sex are without influence on PAH uptake in RCC tissue slices. Interestingly, the accumulation capacity of "intact" tissue of kidneys infested with RCC also depends on the severity of the tumor (stage, diameter), but not on grading and formation of metastases.
Fleck
C
C
Institute of Pharmacology and Toxicology, Friedrich Schiller University Jena, Germany.
Göckeritz
S
S
Schubert
J
J
D000368:Aged; D000818:Animals; D001692:Biological Transport / Q000502:physiology; D002292:Carcinoma, Renal Cell / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007672:Kidney Cortex / Q000378:metabolism; D007677:Kidney Function Tests; D007680:Kidney Neoplasms / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D051381:Rats; D017208:Rats, Wistar; D010130:p-Aminohippuric Acid / Q000493:pharmacokinetics*
D010130:p-Aminohippuric Acid