[Changes in the level of gamma-aminobutyric acid in the blood of children with thyroid diseases].
Blood GABA level was studied in children with thyroid disorders. Increase of GABA level was revealed in thyroid hyperplasia (11 degrees) and euthyroid goiters; in blood of children with diffuse toxic goiter there changes are much more significant. In children with thyroid cancer dramatic increase of GABA content was observed; in the nearest time following thyroidectomy blood GABA level decreased to low values, several mouths later it became normal, in a year and more it became elevated again. In blood from three children with congenital hypothyrosis the level of the mediator was decreased; no changes in GABA level were observed in children with autoimmune thyroiditis. Two hours after falling asleep blood GABA content lowered both in normal children and those with euthyroid goiter and thyroid cancer. The mediator level elevated sharply after finishing physical exercises in normal children and those with euthyroid goiter, while in children with thyroid cancer response of GABAergic system to physical exercises was opposite and in operated children it was absent.
Myshunina
T M
TM
Bol'shova
O V
OV
Samson
O Ia
OIa
Kononenko
V Ia
VIa
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D006801:Humans; D010949:Plasma / Q000737:chemistry; D018709:Statistics, Nonparametric; D013959:Thyroid Diseases / Q000097:blood* / Q000601:surgery; D013997:Time Factors; D005680:gamma-Aminobutyric Acid / Q000097:blood*
D005680:gamma-Aminobutyric Acid