title: Allograft aortic root replacement in prosthetic aortic valve endocarditis: a review of 32 patients.
abstract: BACKGROUND
  This study was conducted to evaluate allograft aortic root replacement in the setting of complicated prosthetic valve endocarditis with extensive annular destruction.
  
  
  METHODS
  From January 1990 through March 1996, 32 patients diagnosed with complicated prosthetic valve endocarditis underwent allograft root replacement. Mean age was 58.3 +/- 13.2 years; 23 patients were men. Mean preoperative New York Heart Association functional class was 3.4. Staphylococcus epidermidis (50%) and Enterococcus faecalis (19%) were the predominant causative microorganisms. Annular abscesses were found in 26 patients (81%), aortic-mitral discontinuity in 14 patients (43%), and left ventricular-aortic discontinuity in 11 patients (34%). A cryopreserved allograft was used in 31 patients (97%) and a fresh antibiotic-treated allograft was used in 1 patient (3%). Mean aortic cross-clamp time was 150 +/- 29 minutes. Mean duration of the postoperative antibiotic treatment was 38.5 +/- 11.8 days.
  
  
  RESULTS
  There were three operative deaths (9.4%); causes of death were multiorgan failure in 2 patients (6.2%) and low cardiac output in 1 patient (3.2%). Six patients (18%) had complete heart block (4 patients already before the operation), 3 patients (9.4%) had temporary respiratory insufficiency, and 1 patient (3.2%) needed temporary hemodialysis. Mean follow-up was 37.4 +/- 22.4 months. Two late deaths occurred: 1 patient had recurrent endocarditis, leading to a false aneurysm, and died at reoperation; another patient died of lung cancer. Actuarial 5-year survival was 87.3% (70% confidence interval, 76.8% to 97.8%); actuarial 5-year freedom from recurrent endocarditis was 96.5% (70% confidence interval, 90.0% to 100%).
  
  
  CONCLUSIONS
  Allograft aortic root replacement is a valuable technique in the complex setting of prosthetic valve endocarditis with involvement of the periannular region. Mortality and morbidity are low.
authors.affiliation: Department of Cardiothoracic Surgery, St. Antonius Ziekenhuis, Nieuwegein, the Netherlands.
authors.forename: K M
authors.initials: KM
authors.lastname: Dossche
authors.forename: J J
authors.initials: JJ
authors.lastname: Defauw
authors.forename: S M
authors.initials: SM
authors.lastname: Ernst
authors.forename: T W
authors.initials: TW
authors.lastname: Craenen
authors.forename: B M
authors.initials: BM
authors.lastname: De Jongh
authors.forename: A B
authors.initials: AB
authors.lastname: de la Rivière
mesh_terms: D000038:Abscess / Q000175:diagnosis / Q000209:etiology / Q000401:mortality / Q000601:surgery; D000206:Actuarial Analysis; D000368:Aged; D001021:Aortic Valve / Q000601:surgery* / Q000637:transplantation; D002315:Cardiopulmonary Bypass / Q000401:mortality; D003646:Debridement / Q000379:methods; D004452:Echocardiography; D004696:Endocarditis / Q000175:diagnosis / Q000209:etiology / Q000401:mortality / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006350:Heart Valve Prosthesis / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008943:Mitral Valve / Q000637:transplantation; D012008:Recurrence; D015996:Survival Rate; D014184:Transplantation, Homologous