title: Is there an advantage to repairing infected mitral valves?
abstract: BACKGROUND
  The therapy for native mitral valve endocarditis is in evolution. Antibiotics have significantly improved survival rates, but patients with complications of endocarditis may require surgical treatment.
  
  
  METHODS
  Between January 1985 and December 1995, 146 patients underwent surgical therapy (repair or replacement) for native mitral valve endocarditis. All patients had documented bacterial endocarditis. Univariate and multivariate analyses were performed to determine predictors of hospital death, long-term event-free survival, and probability of repair. Patients were evaluated in three groups: all patients, patients with acute endocarditis, and patients with chronic endocarditis.
  
  
  RESULTS
  There were ten hospital deaths (6.8%). Patients undergoing repair had a lower hospital mortality rate (p = 0.008) then those having replacement. Event-free survival was improved after mitral valve repair in the overall group (p = 0.02) and in the group with healed (chronic) endocarditis (p = 0.05). Although the acute endocarditis group demonstrated an improved event-free survival rate after mitral valve repair versus replacement (74% versus 20% at 6 years), this did not reach statistical significance.
  
  
  CONCLUSIONS
  We conclude that mitral valve repair is preferable to mitral valve replacement when possible, in patients with complications of endocarditis, as repair results in a lower hospital mortality and an improved long-term survival.
authors.affiliation: Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic Foundation, Ohio, USA.
authors.forename: D D
authors.initials: DD
authors.lastname: Muehrcke
authors.forename: D M
authors.initials: DM
authors.lastname: Cosgrove
authors.forename: B W
authors.initials: BW
authors.lastname: Lytle
authors.forename: P C
authors.initials: PC
authors.lastname: Taylor
authors.forename: A M
authors.initials: AM
authors.lastname: Burgar
authors.forename: C P
authors.initials: CP
authors.lastname: Durnwald
authors.forename: F D
authors.initials: FD
authors.lastname: Loop
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D018572:Disease-Free Survival; D004696:Endocarditis / Q000150:complications* / Q000401:mortality; D005260:Female; D006350:Heart Valve Prosthesis / Q000706:statistics & numerical data; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D008943:Mitral Valve / Q000601:surgery*; D015999:Multivariate Analysis; D011183:Postoperative Complications; D012086:Reoperation; D012307:Risk Factors; D015996:Survival Rate