Tissue distribution and radiation dosimetry of astatine-211-labeled chimeric 81C6, an alpha-particle-emitting immunoconjugate.
A paired-label study was performed in athymic mice bearing subcutaneous D-54 MG human glioma xenografts to compare the localization of human/mouse anti-tenascin chimeric antibody 81C6 labeled by reaction with N-succinimidyl 3-[211At]astatobenzoate and N-succinimidyl 3-[131I]iodobenzoate. Over the 48-h observation period, the distribution of 211At- and 131I-labeled antibody were quite similar in tumor and normal tissues except stomach. These data were used to calculate human radiation doses for both intravenously and intrathecal administered 211At-labeled chimeric 81C6 using a quality factor of 5 for alpha-emissions.
Zalutsky
M R
MR
Department of Radiology, Duke University Medical Center, Durham, NC 27710, USA. zalut001@mc.duke.edu
Stabin
M G
MG
Larsen
R H
RH
Bigner
D D
DD
D000818:Animals; D000911:Antibodies, Monoclonal / Q000008:administration & dosage / Q000737:chemistry* / Q000493:pharmacokinetics; D001246:Astatine / Q000493:pharmacokinetics*; D005910:Glioma / Q000000981:diagnostic imaging*; D006207:Half-Life; D006801:Humans; D007275:Injections, Intravenous; D007278:Injections, Spinal; D007457:Iodine Radioisotopes; D051379:Mice; D009368:Neoplasm Transplantation; D011829:Radiation Dosage; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D014018:Tissue Distribution; D014183:Transplantation, Heterologous
D000911:Antibodies, Monoclonal; D007457:Iodine Radioisotopes; D019275:Radiopharmaceuticals; D001246:Astatine