[Phospholipase A2--acute phase protein after liver surgery?].
BACKGROUND
The exact source of phospholipase A2 is unknown. In this context the liver is discussed because the secretion of phospholipase A2 could be initiated during an acute phase response.


METHODS
Three groups of patients were prospectively established: A liver resection (n = 12); B control (n = 22; oesophageal resection, gastrectomy, rectum resection); C sepsis (n = 5). Blood was collected preoperatively, each day postoperatively for seven days and at the day of discharge. Biochemical procedures: Phospholipase A2, PMN-elastase, C-reactive protein, GPT, GOT, GLDH, cholinesterase.


RESULTS
Postoperatively phospholipase A2 is unchanged in the liver resection and control group, whereas it increases significantly in septic patients. Only following liver resection GPT, GOT and GLDH increase. C-reactive protein is increased in all groups.


CONCLUSIONS
Unchanged phospholipase A2 after liver surgery despite an acute phase response indicated by C-reactive protein does not support the view of phospholipase A2 being of hepatic origin.
Gerhard
F
F
Klinik für Allgemeinchirurgie, Johann Wolfgang Goethe-Universität, Frankfurt am Main.
Treusch
H
H
Hofmann
G E
GE
Büssow
M
M
Hanisch
E
E
D000209:Acute-Phase Proteins / Q000378:metabolism*; D000210:Acute-Phase Reaction / Q000175:diagnosis* / Q000201:enzymology; D000328:Adult; D000368:Aged; D002097:C-Reactive Protein / Q000378:metabolism; D005260:Female; D006498:Hepatectomy; D006801:Humans; D019272:Leukocyte Elastase / Q000097:blood; D008111:Liver Function Tests; D008113:Liver Neoplasms / Q000556:secondary* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D010741:Phospholipases A / Q000097:blood*; D054467:Phospholipases A2; D011183:Postoperative Complications / Q000175:diagnosis* / Q000201:enzymology; D012004:Rectal Neoplasms / Q000601:surgery*; D012016:Reference Values
D000209:Acute-Phase Proteins; D002097:C-Reactive Protein; D010741:Phospholipases A; D054467:Phospholipases A2; D019272:Leukocyte Elastase