[Purging of hemopoietic progenitor cells in autologous transplantation].
The authors describe the results of purification of bone marrow and peripheral progenitor cells (PBPC) for clinical transplantations. Vepeside was used to purify in 1990-1995 a total of 41 bone marrows of adults and children. Of these 23 were transplanted. Maphosphamide was used bone marrow purging in two patients; transplantation was performed in one case. By a combination of Vepeside with methylprednisolone haematopoietic cells of 24 patients were purged, transplantations were performed in 10. Three-day cultivation of haematopoietic cells in the presence of Desferal was used for purging cells of 22 patients with neuroblastoma; transplantations were performed in 10 patients. The authors give the values of nucleated cells, haematopoietic colonies of CFU-GM and CD34 positive cells obtained after purification calculated per kg body weight of the patient and the percentage yields.
Hrubá
A
A
Ustav hematologie a krevní transfuze, Praha.
Skala
J P
JP
Matĕjcková
S
S
Fales
I
I
Vodvárková
S
S
Starý
J
J
Kavan
P
P
Kobylka
P
P
D000328:Adult; D016465:Bone Marrow Purging; D002648:Child; D003520:Cyclophosphamide / Q000031:analogs & derivatives; D003676:Deferoxamine; D005047:Etoposide; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007938:Leukemia / Q000628:therapy; D008775:Methylprednisolone; D009447:Neuroblastoma / Q000628:therapy; D014182:Transplantation, Autologous
C087936:maphosphamide; D005047:Etoposide; D003520:Cyclophosphamide; D003676:Deferoxamine; D008775:Methylprednisolone