[The influence of HX- I on rabbit thyroid allografts].
We studied the anti-rejection effect of HX- I, a preparation of traditional Chinese herbs, on rabbit thyroid allografts. The transplantations were performed on 28 rabbits after total thyroidectomies. The grafting sites were in their pretrachial muscles. These animals were divided into four groups, namely, Group I: homografts: Group I: allografts without medication; Group II: allografts with dexamethason (0.25 mg/(kg.d) intramuscularly), and Group IV: allografts with HX-I water solution, (5g/(kg.d), peros). The medication lasted 28 days. Blood samples were drawn every week postoperatively. Serum T3 and T4 were tested by RIA. The grafts were removed for histopathological evaluation on the 28th day postoperatively. The histopathology of rejection and survival were scored and classified. On the 7th and 14th days, serum T3 and T4 levels were almost the same between groups. On the 21st and 28th days, the T3 and T4 levels were higher in Groups I and IV than those in Group II (P < 0.05). The histopathological findings were; in Group I, damaged follicles with much lymphocytes infiltration and fibrosis, and 6 cases being rejected; in Group II, two deaths and three cases with damaged thyroid tissue and much lymphocytes infiltration; in Group IV, three cases with damaged thyroid tissue and four intact grafts. Our results indicate that HX-I and dexamethason both can inhibit rejection in thyroid allografts in rabbits, but dexamethason has more side effects HX-I has many components and the machanism of its early anti-rejection effect is worthy of further study.
Wang
X
X
Department of General Surgery, First Affiliated Hospital, Chengdu.
Shen
W
W
Tan
J
J
Du
C
C
Li
K
K
Huang
X
X
D000818:Animals; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D006084:Graft Rejection / Q000517:prevention & control*; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008297:Male; D011817:Rabbits; D013961:Thyroid Gland / Q000473:pathology / Q000637:transplantation*; D013965:Thyroidectomy; D013974:Thyroxine / Q000097:blood; D014184:Transplantation, Homologous; D014284:Triiodothyronine / Q000097:blood
D004365:Drugs, Chinese Herbal; D007166:Immunosuppressive Agents; D014284:Triiodothyronine; D013974:Thyroxine