Synthesis and antimycobacterial activity of nitroxanthones. 1st communication: synthesis and differential scanning calorimetry analysis.
The syntheses of mono-; di-, tri- and tetranitroxanthones via intramolecular Friedel-Crafts acylation of nitrated 2-phenoxybenzoic acids as well as via selective stepwise nitration of xanthone and the nitroxanthones gained from the first route are described. The synthesized nitroxanthones investigated by DSC (differential scanning calorimetry) analysis show a surprisingly high thermodynamic stability which was confirmed by quantum chemical calculations.
Ibrom
W G
WG
Department of Pharmacy, Faculty of Chemistry, University of Freiburg, Germany.
Frahm
A W
AW
D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry; D002152:Calorimetry, Differential Scanning; D009574:Nitro Compounds / Q000138:chemical synthesis / Q000737:chemistry; D014966:Xanthenes / Q000138:chemical synthesis* / Q000737:chemistry; D044004:Xanthones
D000890:Anti-Infective Agents; D009574:Nitro Compounds; D014966:Xanthenes; D044004:Xanthones; C009689:xanthone