The influence of coffee with milk and tea with milk on the bioavailability of tetracycline.
The effect of milk added to coffee or black tea on the bioavailability of tetracycline was evaluated in 12 healthy volunteers according to a crossover design. Results showed that even a small volume of milk containing extremely small amounts of calcium severely impair the absorption of the drug, so that the presence of this metal ion should be carefully controlled in order to avoid decreasing the available tetracycline.
Jung
H
H
Departamento de Farmacia, Facultad de Química, UNAM, Universidad Nacional de Mexico, Mexico D.F.
Peregrina
A A
AA
Rodriguez
J M
JM
Moreno-Esparza
R
R
D000328:Adult; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D001682:Biological Availability; D003069:Coffee; D018592:Cross-Over Studies; D005260:Female; D018565:Food-Drug Interactions; D006801:Humans; D008297:Male; D008892:Milk; D013662:Tea; D013752:Tetracycline / Q000008:administration & dosage / Q000493:pharmacokinetics*
D000900:Anti-Bacterial Agents; D003069:Coffee; D013662:Tea; D013752:Tetracycline