title: [Enhancement of treatment efficacy in experimental plague by the sequential administration of antibiotics].
abstract: It was shown that the use of ampicillin, azlocillin or polymyxin 24 or 96 hours after the plague infection at the background of the every-day use of rifampicin in the doses protecting only 30 per cent of the animals from death provided 80-100-percent survival of the animals. With the every-day use of ampicillin, azlocillin or polymyxin in succession with rifampicin there was observed a 3-fold increases in the survival of the albino mice as compared to those exposed to an analogous dose of rifampicin alone. A decrease in the number of administrations of the above drugs and an increase in the intervals between the administration also resulted in a significant rise of the animal survival in comparison with that after the every-day use of a similar dose of rifampicin.
authors.forename: L N
authors.initials: LN
authors.lastname: Makarovskaia
authors.forename: L A
authors.initials: LA
authors.lastname: Tinker
authors.forename: E I
authors.initials: EI
authors.lastname: Markovskaia
authors.forename: V A
authors.initials: VA
authors.lastname: Zurabian
authors.forename: V V
authors.initials: VV
authors.lastname: Ryzhkova
mesh_terms: D000667:Ampicillin / Q000008:administration & dosage*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D001390:Azlocillin / Q000008:administration & dosage*; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination / Q000008:administration & dosage*; D051379:Mice; D010406:Penicillins / Q000008:administration & dosage*; D010930:Plague / Q000188:drug therapy* / Q000401:mortality; D011112:Polymyxin B / Q000008:administration & dosage*; D013997:Time Factors
chemical_list: D000900:Anti-Bacterial Agents; D010406:Penicillins; D000667:Ampicillin; D001390:Azlocillin; D011112:Polymyxin B