title: Comparison of single-biphasic versus sequential-biphasic shocks on defibrillation threshold in pigs.
abstract: Current generation implantable cardioverter defibrillators use monophasic, biphasic, or sequential pulse shocks, most of which truncate after a given time, dumping the remaining charge on the capacitor through an internal resistor. We hypothesized that having an additional current pathway, and delivering the majority of the remaining charge on a single capacitor to the two pathways using additional shock phases, would improve defibrillation efficacy. This hypothesis was tested by comparing DFTs using a simulated single capacitor, single-biphasic shock (two 5-ms pulses separated by 0.2 ms), delivered to coupled pairs of electrodes, to those using a sequential-biphasic shock (four 5-ms pulses separated by 0.2 ms) delivered to separate opposing electrodes, delivered from the same electrodes for both waveforms. In eight open-chest anesthetized pigs, four mesh electrodes (Medtronic TX-7, 6.5 cm2), were sutured on the epicardium of the anterior and posterior surfaces of each ventricle. Shocks were delivered from a 200-microF capacitor bank. Triplicate DFTs were obtained using each waveform in a randomized crossover design. Initial leading edge voltage (mean +/- SEM: 420 +/- 33 V vs 497 +/- 34 V; P < 0.05), initial peak current (4.8 +/- 0.4 A vs 13 +/- 1.1 A; P < 0.001), and delivered energy (16.9 +/- 2.6 J vs 30.4 +/- 5.3 J; P < 0.05) at the DFT were all significantly lower using sequential-biphasic shocks than those using single-biphasic shocks, respectively. We conclude that for direct heart defibrillation, it is worthwhile to combine sequential capability to biphasic shocks and deliver the remaining charge on the capacitor to the two different pathways.
authors.affiliation: Heart and Circulation Group, John P. Robarts Research Institute, London, Ontario, Canada.
authors.forename: Z
authors.initials: Z
authors.lastname: Csanadi
authors.forename: D L
authors.initials: DL
authors.lastname: Jones
authors.forename: G K
authors.initials: GK
authors.lastname: Wood
authors.forename: G J
authors.initials: GJ
authors.lastname: Klein
mesh_terms: D000818:Animals; D017147:Defibrillators, Implantable; D004554:Electric Countershock / Q000379:methods*; D004567:Electrodes, Implanted; D013552:Swine; D014693:Ventricular Fibrillation / Q000628:therapy*