[A case of chronic inflammatory demyelinating neuropathy associated with antibodies to gangliosides GM1 and GalNAc-GD1a].
In January 1993, a 43-year-old man was admitted to our hospital for left wrist-drop. Neurological examinations revealed asymmetrical distal weakness in the upper limbs. Deep tendon reflexes were normal in all 4 limbs. Sensory and autonomic nervous functions were intact. CSF examinations were within normal limits. Thin-layer chromatography with immunostaining revealed serum antibodies that reacted with GM1 and GalNAc-GD1a. Motor nerve conduction studies revealed abnormal temporal dispersion, and a low amplitude of compound muscle action potential in the left radial nerve. Neurological symptoms gradually improved with prednisolone over one and a half years. He was hospitalized again in January 1995, because of right wrist-drop and slight sensory loss of the limbs. Those findings were improved by methylprednisolone (1,000 mg/day) for 3 days. The interval until maximal disability in this patient was more than one month for each admission. This case must belong to inflammatory demyelinating neuropathy.
Tsukaguchi
M
M
Third Department of Internal Medicine, Kagawa Medical University.
Yamada
A
A
Deguchi
K
K
Takeuchi
H
H
Yuki
N
N
D000116:Acetylgalactosamine / Q000276:immunology*; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage; D001323:Autoantibodies / Q000032:analysis*; D002908:Chronic Disease; D003711:Demyelinating Diseases / Q000188:drug therapy / Q000209:etiology*; D005677:G(M1) Ganglioside / Q000276:immunology*; D006801:Humans; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage; D008875:Middle Aged; D011239:Prednisolone / Q000008:administration & dosage; D012008:Recurrence
D000893:Anti-Inflammatory Agents; D001323:Autoantibodies; D005677:G(M1) Ganglioside; D011239:Prednisolone; D000116:Acetylgalactosamine; D008775:Methylprednisolone