Biological effects of the immunomodulator beta 1-3D polyglucose are strongly potentiated by conjugation to biodegradable microbeads.
It is demonstrated that the biological effects of the immunomodulator beta 1-3D polyglucose, when covalently linked to polymethacrylate or biodegradable albumin microbeads, are strongly potentiated. The potentiation is recorded as an increased protection effect of the conjugates in Escherichia coli sepsis in mice, and as increased IL-1 production by murine macrophages in vitro.
Seljelid
R
R
Institute of Medical Biology, University of Tromsø, Norway.
Gao
Q
Q
Berge
A
A
Ugelstad
J
J
D000276:Adjuvants, Immunologic / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D001672:Biocompatible Materials / Q000493:pharmacokinetics / Q000494:pharmacology*; D001711:Biotransformation; D004357:Drug Synergism; D004927:Escherichia coli Infections / Q000517:prevention & control; D005260:Female; D005936:Glucans / Q000737:chemistry / Q000494:pharmacology*; D007155:Immunologic Factors / Q000737:chemistry / Q000494:pharmacology*; D007375:Interleukin-1 / Q000096:biosynthesis; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008863:Microspheres; D047071:beta-Glucans
D000276:Adjuvants, Immunologic; D001672:Biocompatible Materials; D005936:Glucans; D007155:Immunologic Factors; D007375:Interleukin-1; D047071:beta-Glucans; C033363:beta-1,3-glucan