title: Expression of epithelial cadherin and cavernous sinus invasion in human pituitary adenomas.
abstract: Pituitary adenomas generally are regarded as benign tumors, although some invade the cavernous sinus and recur. We examined the epithelial cadherin (E-CD) expression in 30 pituitary adenomas (6 with cavernous sinus invasion and 24 without). Immunoreactivity of E-CD were found in all pituitary adenomas but they were very various. The presence of an association between E-CD expression and cavernous sinus invasion was assessed. There were no significant differences in E-CD expression between invasive and noninvasive adenomas. These results suggest that E-CD expression is not associated with cavernous sinus invasion in pituitary adenomas.
authors.affiliation: Department of Neurosurgery, Hiroshima University School of Medicine, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Kawamoto
authors.forename: T
authors.initials: T
authors.lastname: Mizoue
authors.forename: K
authors.initials: K
authors.lastname: Arita
authors.forename: A
authors.initials: A
authors.lastname: Tominaga
authors.forename: K
authors.initials: K
authors.lastname: Eguchi
authors.forename: K
authors.initials: K
authors.lastname: Kurisu
mesh_terms: D000236:Adenoma / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D000324:Adrenocorticotropic Hormone / Q000032:analysis; D000328:Adult; D000368:Aged; D015820:Cadherins / Q000032:analysis / Q000096:biosynthesis*; D002426:Cavernous Sinus; D005260:Female; D005640:Follicle Stimulating Hormone / Q000032:analysis; D019382:Human Growth Hormone / Q000032:analysis; D006801:Humans; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D010911:Pituitary Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery
chemical_list: D015820:Cadherins; D019382:Human Growth Hormone; D000324:Adrenocorticotropic Hormone; D005640:Follicle Stimulating Hormone