In vivo pharmacokinetics of phosphorothioate oligonucleotides containing contiguous guanosines.
Agrawal
S
S
Hybridon, Inc., Cambridge, MA 02139, USA.
Tan
W
W
Cai
Q
Q
Xie
X
X
Zhang
R
R
D000818:Animals; D001483:Base Sequence; D004355:Drug Stability; D005243:Feces / Q000737:chemistry; D006151:Guanosine; D008297:Male; D008657:Metabolic Clearance Rate; D016376:Oligonucleotides, Antisense / Q000097:blood / Q000737:chemistry / Q000493:pharmacokinetics* / Q000652:urine; D051381:Rats; D017207:Rats, Sprague-Dawley; D013873:Thionucleotides / Q000097:blood / Q000737:chemistry / Q000493:pharmacokinetics* / Q000652:urine; D014018:Tissue Distribution
D016376:Oligonucleotides, Antisense; D013873:Thionucleotides; D006151:Guanosine