title: Particulate bioglass as a grafting material in the treatment of periodontal intrabony defects.
abstract: The present clinical trial was designed to evaluate the effects of a bioactive glass, Perioglas, in the treatment of periodontal intrabony defects. 20 patients, 23-55 years of age (44 sites), with intrabony defects completed the 1-year study. Teeth with furcation involvement were excluded. After completion of initial therapy, defects were randomly assigned to either a test or control procedure. Following flap reflection, root planing and removal of chronic inflammatory tissue in both groups, the test defects were restored with the bioactive glass particulate material. Mucoperiosteal flaps were replaced, sutured and a periodontal dressing was used. All the patients received postoperative antibiotics and analgesics and were seen at 1 week for suture removal. Follow-up was then carried out weekly and at 3 months, 6 months, 9 months and 1 year post-surgery. Plaque score, bleeding score, probing pocket depth (PPD), probing attachment level (PAL) and gingival recession were recorded at baseline, 3 months and 1 year. Standardised radiographs for computer-assisted densitometric image analysis (CADIA) were taken at baseline, immediately post-operatively and at 1 year. The CADIA data showed a significant increase (F-ratio: 15.67, p < 0.001) in radiographic density and volume between the defects treated with the Perioglas when compared to those treated with surgical debridement only. PPD and PAL showed significant improvements in both experimental and control sites, with a greater trend to improvement in the experimental sites. It was concluded that this bioactive glass is effective as an adjunct to conventional surgery in the treatment of intrabony defects.
authors.affiliation: Department of Periodontology, Eastman Dental Institute for Oral Health Care Sciences, University College London, UK.
authors.forename: J S
authors.initials: JS
authors.lastname: Zamet
authors.forename: U R
authors.initials: UR
authors.lastname: Darbar
authors.forename: G S
authors.initials: GS
authors.lastname: Griffiths
authors.forename: J S
authors.initials: JS
authors.lastname: Bulman
authors.forename: U
authors.initials: U
authors.lastname: Brägger
authors.forename: W
authors.initials: W
authors.lastname: Bürgin
authors.forename: H N
authors.initials: HN
authors.lastname: Newman
mesh_terms: D015502:Absorptiometry, Photon; D000328:Adult; D016301:Alveolar Bone Loss / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D001672:Biocompatible Materials; D001843:Bone Cements; D002516:Ceramics; D003646:Debridement; D003774:Dental Plaque Index; D005260:Female; D005500:Follow-Up Studies; D005889:Gingival Recession / Q000473:pathology / Q000601:surgery; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008875:Middle Aged; D017622:Periodontal Attachment Loss / Q000473:pathology / Q000601:surgery; D010512:Periodontal Index; D010514:Periodontal Pocket / Q000473:pathology / Q000601:surgery; D010518:Periodontitis / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D016745:Root Planing; D016037:Single-Blind Method; D013524:Surgical Flaps
chemical_list: D001672:Biocompatible Materials; C022107:Bioglass; D001843:Bone Cements