Resolution of superficial necrolytic dermatitis following excision of a glucagon-secreting pancreatic neoplasm in a dog.
An 11-year-old, neutered male standard poodle was diagnosed with superficial necrolytic dermatitis and a glucagon-secreting pancreatic islet neoplasm based on clinical, biochemical, histopathological, immunohistochemical, and hormonal findings. Hyperglucagonemia, hyperinsulinemia, and hypoaminoacidemia were observed on preoperative laboratory analysis. Abnormal laboratory values returned to normal, and complete resolution of skin lesions occurred after tumor excision. The dog has remained clinically normal for six months following surgery.
Torres
S M
SM
Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St. Paul 55108, USA.
Caywood
D D
DD
O'Brien
T D
TD
O'Leary
T P
TP
McKeever
P J
PJ
D000596:Amino Acids / Q000097:blood; D000682:Amyloid / Q000032:analysis; D000818:Animals; D018273:Carcinoma, Islet Cell / Q000150:complications / Q000378:metabolism / Q000601:surgery / Q000662:veterinary*; D003872:Dermatitis / Q000209:etiology / Q000628:therapy / Q000662:veterinary*; D004283:Dog Diseases / Q000209:etiology* / Q000473:pathology / Q000628:therapy*; D004285:Dogs; D005934:Glucagon / Q000378:metabolism*; D007150:Immunohistochemistry; D007328:Insulin / Q000032:analysis / Q000097:blood; D058228:Islet Amyloid Polypeptide; D008297:Male; D010179:Pancreas / Q000737:chemistry / Q000601:surgery*; D010190:Pancreatic Neoplasms / Q000150:complications / Q000378:metabolism / Q000601:surgery / Q000662:veterinary*; D010191:Pancreatic Polypeptide / Q000032:analysis; D012867:Skin / Q000473:pathology; D013004:Somatostatin / Q000032:analysis; D015032:Zinc / Q000097:blood
D000596:Amino Acids; D000682:Amyloid; D007328:Insulin; D058228:Islet Amyloid Polypeptide; D013004:Somatostatin; D010191:Pancreatic Polypeptide; D005934:Glucagon; D015032:Zinc