title: [A case of sarcoidosis with proliferative retinopathy].
abstract: A 19-year-old female manifested severe bilateral panuveitis with neovascularization in the iris, optic disc, and retina. Fluorescein fundus angiography showed dye leakage from the optic disc and retinal blood vessels, and a large non-perfused area was present in the peripheral retina of the right eye. Sarcoidosis was diagnosed histologically by conjunctival and skin biopsy. Although the patient was given a large dose of a corticosteroid systemically and received panretinal photocoagulation, a dense vitreous hemorrhage and cataract were apparent in the right eye. The right visual acuity decreased to hand motions. A pars plana lensectomy and vitrectomy were performed. After vitrectomy, inflammation and neovascularization regressed and the visual acuity improved to 20/100. Proliferative membrane obtained during vitrectomy was histopathologically studied by light and electron microscopy. Many new vessels containing neutrophils were observed. A direct effect of inflammation as well as ischemia in the retina may have been the stimulus for the proliferative changes.
authors.affiliation: Machida Hospital, Kochi-ken, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Miyao
authors.forename: M
authors.initials: M
authors.lastname: Hongo
authors.forename: K
authors.initials: K
authors.lastname: Uchida
authors.forename: T
authors.initials: T
authors.lastname: Machida
authors.forename: T
authors.initials: T
authors.lastname: Ikeda
authors.forename: Y
authors.initials: Y
authors.lastname: Matsumoto
authors.forename: S
authors.initials: S
authors.lastname: Kinoshita
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D012164:Retinal Diseases / Q000150:complications* / Q000473:pathology; D015861:Retinal Neovascularization / Q000209:etiology; D012507:Sarcoidosis / Q000150:complications* / Q000473:pathology; D014821:Vitrectomy; D014823:Vitreous Hemorrhage / Q000209:etiology