New polyhalogenated monoterpenes from the sea hare Aplysia punctata.
The sea hare Aplysia punctata from Sancti Petri (Cádiz, Spain) contains four new unusual acetates of linear polyhalogenated monoterpenes (5-8) together with four known cyclic derivatives (1-4). The structures were elucidated by interpretation of spectral data. It is suggested that the new constituents of A. punctata might be biotransformation products. Compounds 6-8 showed significant in vitro cytotoxicity against four tumor cell lines.
Ortega
M J
MJ
Departamento de Química Orgánica, Facultad de Ciencias del Mar, Universidad de Cádiz, Spain.
Zubía
E
E
Salv a
J
J
D000818:Animals; D000970:Antineoplastic Agents / Q000302:isolation & purification* / Q000494:pharmacology; D001048:Aplysia / Q000378:metabolism*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D051379:Mice; D013729:Terpenes / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D013729:Terpenes