title: Peripheral primitive neuroectodermal tumor involving the paravertebral and retroperitoneal regions.
abstract: A rare case of peripheral primitive neuroectodermal tumor (PNET) is reported. A 68-year-old woman complaining of lumbago was admitted to our hospital. Diagnosis was made based on pathological findings characterized by Homer Wright-type rosettes. Ultrastructural examination showed the presence of neurosecretory granules and short cytoplasmic processes, which were highly suggestive of neural differentiation. Chromosomal analysis of the neoplastic cells revealed translocation (11;22)(q24;q12), which is often found in Ewing's sarcoma and Askin tumor. These results strengthen the hypothesis of a common histogenesis for these small round cell tumors, and suggest common oncogenesis for these neoplasms.
authors.affiliation: First Department of Medicine, Obihiro Kohsei Hospital.
authors.forename: S
authors.initials: S
authors.lastname: Fukumoto
authors.forename: K
authors.initials: K
authors.lastname: Takamura
authors.forename: K
authors.initials: K
authors.lastname: Nakanishi
authors.forename: M
authors.initials: M
authors.lastname: Yamamoto
authors.forename: S
authors.initials: S
authors.lastname: Inaba
authors.forename: S
authors.initials: S
authors.lastname: Makimura
authors.forename: T
authors.initials: T
authors.lastname: Yoshikawa
authors.forename: T
authors.initials: T
authors.lastname: Terai
mesh_terms: D000368:Aged; D002880:Chromosomes, Human, Pair 11 / Q000235:genetics; D002892:Chromosomes, Human, Pair 22 / Q000235:genetics; D005260:Female; D006801:Humans; D008161:Lumbosacral Region; D008279:Magnetic Resonance Imaging; D008854:Microscopy, Electron; D018242:Neuroectodermal Tumors, Primitive / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology; D018241:Neuroectodermal Tumors, Primitive, Peripheral / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology; D012186:Retroperitoneal Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology; D014057:Tomography, X-Ray Computed; D014178:Translocation, Genetic