title: The complete inventory of the yeast Saccharomyces cerevisiae P-type transport ATPases.
abstract: A total of sixteen open reading frames encoding for P-type ATPases have been identified in the complete genome sequence of Saccharomyces cerevisiae. Phylogenetic analysis distinguishes 6 distinct families. Topology predictions, identification of aminoacid sequence motifs and phenotype analysis of the available mutants suggest that these families correspond to ATPases transporting either H+ (2 members), Ca2+ (2 members), Na+ (3 members), heavy metals (2 members), possibly aminophospholipids (5 members including 4 new ones) or unknown substrates (2 new members). It is proposed that the latter family which has homologs in Tetrahymena thermophila, Plasmodium falciparum and Caenorhabditis elegans constitutes a new group called P4-ATPases with characteristic topology and aminoacid signatures.
authors.affiliation: Unité de Biochimie Physiologique, Université Catholique de Louvain, Louvain-La-Neuve, Belgium.
authors.forename: P
authors.initials: P
authors.lastname: Catty
authors.forename: A
authors.initials: A
authors.lastname: de Kerchove d'Exaerde
authors.forename: A
authors.initials: A
authors.lastname: Goffeau
mesh_terms: D000251:Adenosine Triphosphatases / Q000737:chemistry* / Q000235:genetics; D000595:Amino Acid Sequence; D016681:Genome, Fungal; D008969:Molecular Sequence Data; D010802:Phylogeny; D012441:Saccharomyces cerevisiae / Q000737:chemistry* / Q000201:enzymology* / Q000235:genetics
chemical_list: D000251:Adenosine Triphosphatases