title: Does pharmacokinetic variability influence the efficacy of high-dose methotrexate for the treatment of children with acute lymphoblastic leukemia: what can we learn from small studies?
authors.affiliation: Department of Pharmaceutical Sciences, St Jude Children's Research Hospital, Memphis, TN 38101, USA.
authors.forename: W E
authors.initials: WE
authors.lastname: Evans
authors.forename: M V
authors.initials: MV
authors.lastname: Relling
authors.forename: J M
authors.initials: JM
authors.lastname: Boyett
authors.forename: C H
authors.initials: CH
authors.lastname: Pui
mesh_terms: D000964:Antimetabolites, Antineoplastic / Q000493:pharmacokinetics* / Q000627:therapeutic use; D002648:Child; D018572:Disease-Free Survival; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008727:Methotrexate / Q000493:pharmacokinetics* / Q000627:therapeutic use; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000097:blood / Q000188:drug therapy*; D011379:Prognosis; D012008:Recurrence; D018570:Risk Assessment
chemical_list: D000964:Antimetabolites, Antineoplastic; D008727:Methotrexate