title: Response of human hair cortical cells to fractionated radiotherapy.
abstract: Hair cortical cell counting (HCCC) represents a non-invasive, in-vivo measure of cell kill in the human integument. Sixty-six patients undergoing conventionally fractionated, external beam radiotherapy for early stage carcinoma of the prostate had groin hair samples counted. This technique is a sensitive and reproducible measure of radiation effect and may have applicability as an in-vivo prediction tool or in the field of biological dosimetry. A repopulative follicular response occurring at 3-4 weeks may explain flattening of the dose response curve.
authors.affiliation: Newcastle Mater Misericordiae Hospital, Hunter, NSW, Australia.
authors.forename: C S
authors.initials: CS
authors.lastname: Hamilton
authors.forename: C S
authors.initials: CS
authors.lastname: Potten
authors.forename: J W
authors.initials: JW
authors.lastname: Denham
authors.forename: P C
authors.initials: PC
authors.lastname: O'Brien
authors.forename: T
authors.initials: T
authors.lastname: Kron
authors.forename: P
authors.initials: P
authors.lastname: Ostwald
authors.forename: S
authors.initials: S
authors.lastname: Wright
authors.forename: J
authors.initials: J
authors.lastname: Ramsden
mesh_terms: D004307:Dose-Response Relationship, Radiation; D018859:Hair Follicle / Q000166:cytology / Q000528:radiation effects*; D006801:Humans; D008297:Male; D011237:Predictive Value of Tests; D011471:Prostatic Neoplasms / Q000532:radiotherapy; D011879:Radiotherapy Dosage