Generating biological models through gene transfer to domestic animals.
Transgenic domestic animals remain infrequently used as models for biochemical, biomedical or pharmaceutical studies. The difficulty in obtaining these animals and the cost of their maintenance explains this situation. This review briefly summarizes the different techniques of gene transfer, targeted or not, and also the techniques for constructing vectors for transgene expression. A few examples of domestic animal models are also reported.
Houdebine
L M
LM
Unité de différenciation cellulaire, Inra, Jouy-en-Josas, France. Imshe@biotec.jouy.inra.fr
D000818:Animals; D000829:Animals, Domestic; D030801:Animals, Genetically Modified; D018014:Gene Transfer Techniques; D005818:Genetic Engineering / Q000379:methods*; D005822:Genetic Vectors; D006801:Humans; D008954:Models, Biological; D013234:Stem Cells; D014183:Transplantation, Heterologous