Lymphocyte subset abnormalities in canine leishmaniasis.
Peripheral blood lymphocyte subpopulations were studied in 42 Leishmania infantum-infected dogs using flow cytometry. Twenty-two healthy dogs were used as a control group. Analysis of the B-cell populations showed a reduction in the number of CD21+ cells in all the infected dogs. On the other hand, the disease was found to be associated with a striking decrease in the number of CD21+ cells and of T-lymphocyte CD4+ cells in comparison with asymptomatic dogs and with healthy dogs. This study suggests that the dysimmunity which is observed with leishmaniasis may be linked to a reduced number of T-lymphocyte CD4+ cells.
Bourdoiseau
G
G
Département de Pathologie et Clinique des Carnivores Domestiques, Ecole Nationale Vétérinaire de Lyon, Marcy I'Etoile, France.
Bonnefont
C
C
Magnol
J P
JP
Saint-André
I
I
Chabanne
L
L
D000818:Animals; D016175:B-Lymphocyte Subsets / Q000276:immunology; D004283:Dog Diseases / Q000097:blood / Q000209:etiology / Q000276:immunology*; D004285:Dogs; D005260:Female; D005434:Flow Cytometry; D018314:Leishmania infantum; D007898:Leishmaniasis, Visceral / Q000097:blood / Q000276:immunology / Q000662:veterinary*; D016131:Lymphocyte Subsets / Q000276:immunology*; D008297:Male; D016176:T-Lymphocyte Subsets / Q000276:immunology