title: Determination of acyclovir in human plasma by high-performance liquid chromatography.
abstract: A selective and sensitive isocratic high-performance liquid chromatographic method for the analysis of acyclovir in human plasma was described. Acid deproteinisation was used as sample treatment. Mean analytical recoveries were higher than 94% at low and high concentrations. The quantification limit was 0.1 mg/l for a plasma volume of 500 microl and precision study exhibits coefficients of variation lower than 5%. The method is suitable for therapeutic monitoring of acyclovir concentrations in organ-transplant recipients.
authors.affiliation: Institut des Sciences Pharmaceutiques et Biologiques, Laboratoire de Pharmacie Clinique et d'Evaluation du Médicament, Lyon, France.
authors.forename: R
authors.initials: R
authors.lastname: Boulieu
authors.forename: C
authors.initials: C
authors.lastname: Gallant
authors.forename: N
authors.initials: N
authors.lastname: Silberstein
mesh_terms: D000212:Acyclovir / Q000097:blood*; D000998:Antiviral Agents / Q000097:blood*; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D012680:Sensitivity and Specificity
chemical_list: D000998:Antiviral Agents; D000212:Acyclovir