title: The biochemical investigation of epilepsy in childhood.
abstract: Metabolic disorders are a relatively uncommon, but important, cause of childhood seizures. Routinely searching for a metabolic disorder in epilepsy is usually unrewarding. Children and adolescents with epilepsy can be selected for appropriate biochemical investigation by considering the seizure type, age of onset, EEG appearance, family history, clinical findings and the results of brain imaging. A limited number of biochemical screening tests can be used to categorize the more common metabolic disorders associated with seizures.
authors.affiliation: Department of Paediatrics, Countess of Chester Hospital, UK.
authors.forename: J
authors.initials: J
authors.lastname: Gibbs
authors.forename: R E
authors.initials: RE
authors.lastname: Appleton
mesh_terms: D000293:Adolescent; D017668:Age of Onset; D015415:Biomarkers; D001921:Brain / Q000000981:diagnostic imaging; D002648:Child; D004569:Electroencephalography; D004827:Epilepsy / Q000453:epidemiology / Q000209:etiology* / Q000235:genetics; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008659:Metabolic Diseases / Q000175:diagnosis / Q000503:physiopathology* / Q000628:therapy; D012640:Seizures / Q000209:etiology* / Q000503:physiopathology; D014057:Tomography, X-Ray Computed
chemical_list: D015415:Biomarkers