title: Brain-gut induction of heat shock protein (HSP) 70 mRNA by psychophysiological stress in rats.
abstract: Restraint water-immersion stress-induced expression of heat shock protein (HSP)70 mRNA in the cerebral cortex and stomach of rats was evaluated by Northern blotting. Cerebral and gastric HSP70 mRNA significantly increased in the 6 h-stressed rats and the amount of mRNA measured as optical densities was highest in the 12 h-stressed rats. These data confirmed our previous observations and suggest that families of HSPs play a salient cytoprotective role in stress-vulnerable organs.
authors.affiliation: Department of Psychosomatic Medicine, Tohoku University School of Medicine, Aoba-ku, Sendai, Japan. sfukudo@mail.cc.tohoku.ac.jp
authors.forename: S
authors.initials: S
authors.lastname: Fukudo
authors.forename: K
authors.initials: K
authors.lastname: Abe
authors.forename: M
authors.initials: M
authors.lastname: Hongo
authors.forename: A
authors.initials: A
authors.lastname: Utsumi
authors.forename: Y
authors.initials: Y
authors.lastname: Itoyama
mesh_terms: D000818:Animals; D002540:Cerebral Cortex / Q000378:metabolism*; D005753:Gastric Mucosa / Q000378:metabolism*; D018840:HSP70 Heat-Shock Proteins / Q000096:biosynthesis*; D007101:Immersion; D008297:Male; D012333:RNA, Messenger / Q000096:biosynthesis; D051381:Rats; D017208:Rats, Wistar; D012149:Restraint, Physical; D013315:Stress, Psychological / Q000378:metabolism*; D014158:Transcription, Genetic
chemical_list: D018840:HSP70 Heat-Shock Proteins; D012333:RNA, Messenger