[A comparative study of the permeability across the hemato-encephalic barrier and of the effect on cerebral blood flow of the new neurotropic agent calcium ketohomopantothenate and of pantogam].
The permeability through the blood-brain barrier of N-(4-hydroxy-3,3 dimethyl-2-oxo-1-butiryl) gamma-aminobutyric acid calcium salt, a new neurotropic drug calcium ketohomopantothenate (KPA-Ca), was studied in comparison with that of calcium homopantothenate, pantogam (P) Liquid chromatography analysis showed that after oral administration of KPA-Ca and P both forms of these agents, namely, oxy- and keto- derivatives of homopantothenic acid, were found in the brain of experimental rats, the KPA-Ca (ketoform) content being higher. Pharmacological studies showed that KPA-Ca penetrates the blood-brain barrier in greater amounts and causes a higher effect on the rate of cerebral blood flow when it is administered per os in a dose of 50 mg/kg.
Nasybullina
N M
NM
Gunar
V I
VI
Zherdev
V P
VP
Sariev
A K
AK
Kozlova
G S
GS
Mirzoian
R S
RS
Gan'shina
T S
TS
Karaev
A L
AL
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001812:Blood-Brain Barrier; D001923:Brain Chemistry / Q000187:drug effects; D002415:Cats; D002463:Cell Membrane Permeability; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D002849:Chromatography, Gas / Q000379:methods; D010205:Pantothenic Acid / Q000031:analogs & derivatives* / Q000032:analysis / Q000493:pharmacokinetics / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000032:analysis / Q000493:pharmacokinetics / Q000494:pharmacology
C016030:pantogab; D010205:Pantothenic Acid; D005680:gamma-Aminobutyric Acid