Simvastatin-induced myopathy in a patient treated for hypercholesterolemia. Morphological aspects.
Functional and histological changes in skeletal muscle developing during hypolipemic therapy, especially with 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors are rare. This paper reports a case of simvastatin-induced myopathy confirmed histopathologically and ultrastructurally.
Wicher-Muniak
E
E
Department of Clinical and Experimental Pathomorphology, Jagiellonian University Medical College, Kraków.
Zmudka
K
K
Dabroś
W
W
Dudek
D
D
Stachura
J
J
D006801:Humans; D006937:Hypercholesterolemia / Q000188:drug therapy*; D008148:Lovastatin / Q000009:adverse effects / Q000031:analogs & derivatives*; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000187:drug effects / Q000473:pathology / Q000648:ultrastructure; D009135:Muscular Diseases / Q000139:chemically induced* / Q000473:pathology*; D019821:Simvastatin
D008148:Lovastatin; D019821:Simvastatin