title: Induction of gelatinase B and MCP-2 in baboons during sublethal and lethal bacteraemia.
abstract: Intravenous injection of sublethal or lethal doses of Escherichia coli in baboons resulted in increased serum levels of the matrix metalloprotease gelatinase B and the chemokine monocyte chemotactic protein 2 (MCP-2). In both animal models, gelatinase B appeared faster than MCP-2. After sublethal challenge, serum levels of gelatinase B and MCP-2 were found to be correlated, reaching peak levels between 2 and 4 h after bacterial challenge. After lethal challenge, however, MCP-2 tended to increase until 10 h. The kinetics of appearance suggest induction of release of gelatinase B and de novo synthesis and secretion of MCP-2, both by endotoxin.
authors.affiliation: Rega Institute for Medical Research, University of Leuven, Belgium.
authors.forename: L
authors.initials: L
authors.lastname: Paemen
authors.forename: P M
authors.initials: PM
authors.lastname: Jansen
authors.forename: P
authors.initials: P
authors.lastname: Proost
authors.forename: J
authors.initials: J
authors.lastname: Van Damme
authors.forename: G
authors.initials: G
authors.lastname: Opdenakker
authors.forename: E
authors.initials: E
authors.lastname: Hack
authors.forename: F B
authors.initials: FB
authors.lastname: Taylor
mesh_terms: D000818:Animals; D016470:Bacteremia / Q000201:enzymology* / Q000276:immunology*; D054412:Chemokine CCL8; D017364:Collagenases / Q000096:biosynthesis* / Q000097:blood; D004195:Disease Models, Animal; D004731:Endotoxins / Q000633:toxicity; D004790:Enzyme Induction; D004927:Escherichia coli Infections / Q000201:enzymology* / Q000276:immunology*; D007700:Kinetics; D020780:Matrix Metalloproteinase 9; D018945:Monocyte Chemoattractant Proteins / Q000096:biosynthesis* / Q000097:blood; D010215:Papio
chemical_list: D054412:Chemokine CCL8; D004731:Endotoxins; D018945:Monocyte Chemoattractant Proteins; D017364:Collagenases; D020780:Matrix Metalloproteinase 9