Synthesis and pharmacological activities of some 2,3,4,5-tetrahydro[1,5]benzo[f]thiazepines.
In search of new biological active agents in the series of [1,5]benzothiazepines, some 2,3,4,5-tetrahydro-N-(5-morpholinopentanoyl)-[1,5]benzo[f] thiazepines were synthesized and examined in vitro for their calcium antagonist activity compared to the Diltiazem one.
Saturnino
C
C
Università degli Studi di Salerno, Facoltà di Farmacia, Penta, Italia.
Saturnino
P
P
De Martino
G
G
Lancelot
J C
JC
Perrine
D
D
Rault
S
S
Robba
M
M
Rossi
F
F
D000818:Animals; D002121:Calcium Channel Blockers / Q000138:chemical synthesis / Q000494:pharmacology*; D004110:Diltiazem / Q000737:chemistry / Q000494:pharmacology; D005260:Female; D066298:In Vitro Techniques; D008297:Male; D015394:Molecular Structure; D051381:Rats; D017207:Rats, Sprague-Dawley; D013841:Thiazepines / Q000138:chemical synthesis / Q000494:pharmacology*
C106746:1,5-benzothiazepine; D002121:Calcium Channel Blockers; D013841:Thiazepines; D004110:Diltiazem