title: Giant antral ulcer: a rare presentation of eosinophilic gastroenteritis--case report and review of the literature.
abstract: A 24-yr-old female presented with a giant gastric ulcer and anemia. She suffered from a transient infantile malabsorption syndrome with eosinophilia. The diagnosis of eosinophilic gastroenteritis associated with the gastric ulcer was made by endoscopic biopsy. Ulcer healing was refractory to medical therapy and partial gastrectomy was performed. Histologic examination revealed transmural eosinophilic infiltrates with mast cell infiltrates in the gastric wall. This case illustrates (1) an extremely rare presentation of eosinophilic gastroenteritis--giant, refractory, gastric ulcer; (2) a potential pathogenic role for mast cells in this syndrome; and (3) the chronic and relapsing nature of the syndrome.
authors.affiliation: Department of Surgical Pathology, Loyola University Medical Center and Hines VA Hospital, Maywood, Illinois 60153-3304, USA.
authors.forename: T
authors.initials: T
authors.lastname: Kristopaitis
authors.forename: C
authors.initials: C
authors.lastname: Neghme
authors.forename: S L
authors.initials: SL
authors.lastname: Yong
authors.forename: G
authors.initials: G
authors.lastname: Chejfec
authors.forename: G
authors.initials: G
authors.lastname: Aranha
authors.forename: A
authors.initials: A
authors.lastname: Keshavarzian
mesh_terms: D000328:Adult; D001706:Biopsy; D002908:Chronic Disease; D003937:Diagnosis, Differential; D004802:Eosinophilia / Q000150:complications* / Q000175:diagnosis*; D005260:Female; D005759:Gastroenteritis / Q000150:complications* / Q000473:pathology*; D005773:Gastroscopy; D006801:Humans; D007124:Immunoenzyme Techniques; D011706:Pyloric Antrum; D013276:Stomach Ulcer / Q000209:etiology* / Q000628:therapy