Candida endocarditis in a child with hyperimmunoglobulinemia E syndrome.
Hyperimmunoglobulin E syndrome (HIE) is a disorder characterized by extremely elevated serum levels of IgE and recurrent infections. Patients are particularly predisposed to have staphylococcal abscesses, usually involving skin, lungs, and joints; but they are also at risk for infections with other bacteria and fungi. We report the case of a 46-month-old boy with HIE who had Candida endocarditis and sepsis with a large fungal mass extending through the tricuspid valve and into the surrounding heart tissue, requiring surgical excision and replacement with a prosthetic valve. He had an indwelling central line for previous antibiotic therapy and had oral thrush for a month before presentation, which had been treated with oral nystatin. He was first seen with very dark urine, a new murmur, petechial rash, in shock, and disseminated intravascular coagulation. The white blood cell count was 38,700 with 70% segmented neutrophils, 9% banded neutrophils, 15% lymphocytes, 4% monocytes, and 2% eosinophils. Hemoglobin was 7.1, and platelet count was 14,000. Prothrombin time was 15.5, and partial thromboplastin time was 31; fibrinogen level was 110 mg/ml, and fibrin degradation products were greater than 40 mg/ml. Serum IgE was 38,664 and 44,510 on repeat measurement. He has had recurrent staphylococcal pneumonias with pneumatoceles, twice requiring segmental lung resection. Blood and tricuspid valve cultures grew Candida albicans. He was treated with amphotericin and flucytosine, and later switched to fluconazole, with good response to therapy. A literature search revealed no other reported case of Candida endocarditis in patients with HIE. Fungai endocarditis is a rare complication, which may occur in patients with HIE and indwelling central catheters.
Yates
A B
AB
University of Mississippi Medical Center, School of Medicine, Department of Pediatrics, Jackson 39216-4505, USA.
Mehrotra
D
D
Moffitt
J E
JE
D002177:Candidiasis / Q000276:immunology*; D002675:Child, Preschool; D004696:Endocarditis / Q000188:drug therapy / Q000276:immunology* / Q000382:microbiology*; D006801:Humans; D006942:Hypergammaglobulinemia / Q000188:drug therapy / Q000276:immunology / Q000382:microbiology; D007073:Immunoglobulin E / Q000096:biosynthesis; D007589:Job Syndrome / Q000188:drug therapy / Q000276:immunology / Q000382:microbiology*; D008297:Male
D007073:Immunoglobulin E