[The effect of stimulants of the mononuclear phagocytosing system on protein synthesis in rat organs and tissues].
It has been demonstrated in rat experiments that stimulation of the mononuclear phagocytizing system with a polysaccharide intensifies protein biosynthesis in various organs and tissues. In administration of high-polymer RNA into the organism increase of protein synthesis was encountered only in immunocompetent and blood-forming tissues. It is concluded that a stimulating effect in relation to macrophages is characteristic of high-polymer compounds which are absorbed by them due to receptor mediated endocytosis. The differences in the receptor apparatus of the resident macrophages determine the discovered difference in the intensification of protein biosynthesis in the organs and tissues of rats.
Panin
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Khar'kovskiĭ
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D000276:Adjuvants, Immunologic / Q000494:pharmacology; D000818:Animals; D007963:Leukocytes, Mononuclear / Q000187:drug effects*; D008264:Macrophages / Q000187:drug effects; D008297:Male; D009696:Nucleic Acids / Q000494:pharmacology; D009930:Organic Chemicals; D010586:Phagocytes / Q000187:drug effects*; D011354:Prodigiozan / Q000494:pharmacology; D014176:Protein Biosynthesis; D011506:Proteins / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D013268:Stimulation, Chemical; D013997:Time Factors
D000276:Adjuvants, Immunologic; D009696:Nucleic Acids; D009930:Organic Chemicals; D011506:Proteins; C065320:polyribonate; C013683:sodium nucleinate; D011354:Prodigiozan