title: Dietary effect of a symmetrical triacylglycerol, 1,3-biseicosapentaenoyl-2-gamma-linolenoyl glycerol, on fatty acid composition of guinea pigs.
abstract: The dietary effect of 1,3-biseicosapentaenoyl-2-gamma-linolenoyl glycerol (STG) on the fatty acid composition of guinea pigs was examined and compared with that of an eicosapentaenoic acid ethyl ester (EPA-E) and of a soybean oil (SBO) diet. In terms of content of plasma lipid, EPA-E had a greater hypolipidemic effect than STG. On the other hand, in terms of EPA incorporation, contents of EPA in liver lipid were almost the same in the STG and EPA-E groups. Considering that the amount of EPA administered in the EPA-E group was almost 1.5 times that of the STG group, EPA may be absorbed more effectively as the glycerol ester than as the ethyl ester in guinea pigs. In all the tissue lipids, the STG group had a higher unsaturation index (UI) than the EPA-E group even though there is a lower UI in the STG diet than the EPA-E diet. These results suggest that greater amounts of desaturase products as a whole were synthesized in the STG group than in the other two groups. The dihomo-gamma-linolenic acid/arachidonic acid (DGLA/AA) ratio in plasma total lipids in the STG group was 3.5 times that of SBO group, and the DGLA/AA ratio in the EPA-E group was half that of the SBO group. In liver lipid, the ratios of DGLA/AA and EPA/AA in the STG group were 0.687 and 0.488 (phosphatidylcholine fraction) and 0.237 and 0.752 (phosphatidylethanolamine fraction), respectively. The ratio of DGLA/AA as well as the high EPA/AA ratio obtained in the present study with the STG diet may lead to physiological alterations, including enhanced synthesis of 1- and 3-series eicosanoids.
authors.affiliation: Tsukuba Research Institute, Sandoz Pharmaceuticals Ltd., Ibaraki, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Ohba
authors.forename: N
authors.initials: N
authors.lastname: Akahane
authors.forename: T
authors.initials: T
authors.lastname: Wakabayashi
authors.forename: T
authors.initials: T
authors.lastname: Nakahara
authors.forename: T
authors.initials: T
authors.lastname: Yokochi
authors.forename: K
authors.initials: K
authors.lastname: Yanagi
authors.forename: N
authors.initials: N
authors.lastname: Ohshima
mesh_terms: D015126:8,11,14-Eicosatrienoic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D016718:Arachidonic Acid / Q000378:metabolism; D001794:Blood Pressure / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D002784:Cholesterol / Q000097:blood; D004032:Diet; D015118:Eicosapentaenoic Acid / Q000031:analogs & derivatives / Q000494:pharmacology; D044943:Fatty Acid Desaturases / Q000378:metabolism; D005227:Fatty Acids / Q000032:analysis* / Q000378:metabolism; D006168:Guinea Pigs; D050356:Lipid Metabolism; D008055:Lipids / Q000097:blood / Q000737:chemistry*; D008099:Liver / Q000737:chemistry / Q000187:drug effects; D008297:Male; D010743:Phospholipids / Q000097:blood; D013024:Soybean Oil / Q000494:pharmacology; D014280:Triglycerides / Q000097:blood / Q000494:pharmacology*
chemical_list: D005227:Fatty Acids; D008055:Lipids; D010743:Phospholipids; D014280:Triglycerides; C081568:tridihomo-gamma-linolenoylglycerol; D016718:Arachidonic Acid; C035276:eicosapentaenoic acid ethyl ester; D013024:Soybean Oil; D002784:Cholesterol; D015118:Eicosapentaenoic Acid; D044943:Fatty Acid Desaturases; C094563:delta-15 desaturase; D015126:8,11,14-Eicosatrienoic Acid