title: Cloning, characterization, and chromosomal localization of human liver form cytochrome c oxidase subunit VIa related genes.
abstract: The chromosomal location of human cytochrome c oxidase (COX) subunit VIa Liver (VIa-L) isoform related sequences has been determined by a combination of in situ hybridization and analysis of human-hamster somatic cell hybrid panels. COX VIa-L related sequences were present on chromosomes 6 and 12. It has been verified that at least two COX VIa-L genes are on chromosome 6, one of which is a pseudogene. In total, four COX VIa-L related sequences have been cloned and their nucleotide sequences analyzed. At least three of the sequences represent pseudogenes; their relatedness to the COX VIa-L cDNA is discussed.
authors.affiliation: Centre for Cardiovascular Research, Toronto Hospital, ON, Canada.
authors.forename: F
authors.initials: F
authors.lastname: Merante
authors.forename: M
authors.initials: M
authors.lastname: Ling
authors.forename: A M
authors.initials: AM
authors.lastname: Duncan
authors.forename: C
authors.initials: C
authors.lastname: Duff
authors.forename: B H
authors.initials: BH
authors.lastname: Robinson
mesh_terms: D000818:Animals; D001483:Base Sequence; D015139:Blotting, Southern; D002874:Chromosome Mapping; D002881:Chromosomes, Human, Pair 12; D002896:Chromosomes, Human, Pair 6; D003001:Cloning, Molecular; D006224:Cricetinae; D003576:Electron Transport Complex IV / Q000235:genetics*; D006801:Humans; D006822:Hybrid Cells; D007527:Isoenzymes; D008099:Liver / Q000201:enzymology*; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D011544:Pseudogenes; D017422:Sequence Analysis, DNA; D012689:Sequence Homology, Nucleic Acid; D013045:Species Specificity
chemical_list: D007527:Isoenzymes; D003576:Electron Transport Complex IV