title: Changes in the biliary excretion of exogenous organic anions by streptozotocin-induced diabetes.
abstract: A transient depression of blood-glucose level was found after streptozotocin administration, which can be explained by insulin release due to the destroying effect of streptozotocin on beta-cells of pancreas, the biliary flow was elevated, when blood sugar level was low. After the transient decrease the blood glucose level was elevated and remained in a diabetic range (300-500 mg/100 ml). During the diabetic period a biphasic change was observed in the biliary flow: 23-48 hours after streptozotocin injection a depression, however, 5-10 days after streptozotocin administration an elevation was detected in the bile flow. Changes found in biliary excretion rate of exogenous organic anions were parallel with those of biliary flow.
authors.affiliation: Deaprtment of Pharmacology, University Medical School, Pécs, Hungary.
authors.forename: S
authors.initials: S
authors.lastname: Bojcsev
authors.forename: A
authors.initials: A
authors.lastname: Rafiei
authors.forename: E
authors.initials: E
authors.lastname: Fischer
mesh_terms: D000818:Animals; D000838:Anions / Q000378:metabolism*; D001646:Bile / Q000378:metabolism*; D001786:Blood Glucose / Q000032:analysis; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
chemical_list: D000838:Anions; D001786:Blood Glucose