title: A clinical evaluation of guided tissue regeneration with a bioabsorbable matrix membrane combined with an allograft bone graft. A series of case reports.
abstract: THE PURPOSE OF THIS STUDY was to evaluate the clinical effectiveness of a surgical technique in treating periodontal defects. The technique combined tetracycline treatment of a root planed root, grafting of the osseous defect with a demineralized freeze-dried bone allograft combined with tetracycline and the placement of a bioabsorbable matrix membrane, made of polylactic acid softened with citric acid ester. Thirty defects were treated in 27 patients. Statistically significant changes, as a result of the surgical procedure, were observed in marginal recession (mean: 0.5 mm), probing depth reductions (mean: 5.7 mm), and attachment level gain (mean: 5.2 mm). No statistically significant difference existed between the results in the furcation and non-furcation groups. The defects with probing depths > or = 10 mm had a greater mean probing depth reduction (7.4 mm) and mean attachment level improvement (7.2 mm) than the defects with < 10 mm probing depths (probing depth reduction 4.5 mm and attachment level gain 3.9 mm). The proposed surgical procedure seemed to be an effective method to treat periodontal defects.
authors.forename: R J
authors.initials: RJ
authors.lastname: Harris
mesh_terms: D000328:Adult; D000368:Aged; D016301:Alveolar Bone Loss / Q000601:surgery*; D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use; D001673:Biodegradation, Environmental; D018775:Bone Demineralization Technique; D016025:Bone Transplantation / Q000379:methods; D019343:Citric Acid; D005260:Female; D017823:Furcation Defects / Q000601:surgery; D005889:Gingival Recession / Q000601:surgery; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods*; D006801:Humans; D019344:Lactic Acid; D008297:Male; D008567:Membranes, Artificial; D008875:Middle Aged; D010043:Outcome and Process Assessment, Health Care; D017622:Periodontal Attachment Loss / Q000601:surgery; D010512:Periodontal Index; D011091:Polyesters; D011108:Polymers; D016745:Root Planing; D013499:Surface Properties / Q000187:drug effects; D013752:Tetracycline / Q000494:pharmacology / Q000627:therapeutic use; D014092:Tooth Root / Q000187:drug effects*
chemical_list: D000900:Anti-Bacterial Agents; D008567:Membranes, Artificial; D011091:Polyesters; D011108:Polymers; D019343:Citric Acid; D019344:Lactic Acid; C033616:poly(lactide); D013752:Tetracycline