[An experimental study on homoharringtonine and glaucoma surgery].
OBJECTIVE
To test the inhibiting effect of a Chinese herbal drug. Homoharringtonine (HH) on the wound healing process at the filtering site in an experimental model.


METHODS
Posterior sclerectomies were performed in 20 rabbits. Postoperatively one eye of each rabbit received subconjunctival injections of HH and fellow eye received saline injections in a randomized masked fashion.


RESULTS
14 days after operation, intraocular pressure decreased significantly compared with that of control (P < 0.05). The number of filtration blebs was greater than that of control (14/6). On pathological examination, the number of fibroblasts per square measure of cross section of tissue cut from filtration region that was diminished significantly compared with that of control (P < 0.01). There were no serious and permanent ocular toxic and side effects.


CONCLUSIONS
The study suggests that the HH can inhibit cicatrization at the glaucoma filtering site, promote the formation of filtering blebs and provide a sufficient evidence for the further clinical use of HH.
Peng
D
D
Zhongshan Ophthalmic Centre, Sun Yat-sen University of Medical Sciences, Guangzhou, China.
Tian
X
X
Zeng
S
S
Yu
K
K
Zheng
G
G
Zhang
J
J
D000818:Animals; D002921:Cicatrix / Q000209:etiology / Q000517:prevention & control*; D005260:Female; D018463:Filtering Surgery / Q000009:adverse effects*; D005901:Glaucoma / Q000601:surgery*; D006248:Harringtonines / Q000627:therapeutic use*; D008297:Male; D011817:Rabbits; D011897:Random Allocation
D006248:Harringtonines