title: [A case of malignant lymphoma after renal transplantation].
abstract: A case of a primary brain malignant lymphoma after renal transplantation and immunosuppressive therapy is reported. A 41-year-old male patient had been treated with 125 mg/day of azathioprine and 10 mg/day of prednisolone after renal transplantation. He had also been suffering from various infectious diseases. Multiple brain tumors were found and diagnosed as having B-cell, diffuse large cell type malignant lymphoma. In spite of moderate response to irradiation, he died of pneumonia. The anti-Epstein Barr virus antibodies changed from a negative to a positive level after renal transplantation and they increased markedly after brain malignant lymphoma had been found. The number of T- and B-lymphocytes also decreased markedly at that time. So the Epstein-Barr virus was suspected to be the cause of the malignant lymphoma.
authors.affiliation: Department of Neurosurgery, Chukyo Hospital.
authors.forename: H
authors.initials: H
authors.lastname: Oyama
authors.forename: K
authors.initials: K
authors.lastname: Yamao
authors.forename: T
authors.initials: T
authors.lastname: Sugiyama
authors.forename: O
authors.initials: O
authors.lastname: Matsuura
authors.forename: S
authors.initials: S
authors.lastname: Murakami
authors.forename: K
authors.initials: K
authors.lastname: Ikeda
authors.forename: S
authors.initials: S
authors.lastname: Inoue
mesh_terms: D000328:Adult; D001379:Azathioprine / Q000009:adverse effects*; D001932:Brain Neoplasms / Q000209:etiology*; D006566:Herpesviridae Infections / Q000150:complications; D004854:Herpesvirus 4, Human; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D016030:Kidney Transplantation; D016393:Lymphoma, B-Cell / Q000209:etiology*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000209:etiology*; D008297:Male; D011183:Postoperative Complications; D011239:Prednisolone / Q000009:adverse effects*
chemical_list: D007166:Immunosuppressive Agents; D011239:Prednisolone; D001379:Azathioprine