Soluble intercellular adhesion molecule-1 level in sera is elevated in perennial allergic rhinitis.
Soluble intercellular adhesion molecule-1 (sICAM-1) in sera was measured in some allergic disorders, but serum sICAM-1 levels in perennial allergic rhinitis remain to be determined. Our study was aimed at elucidating whether the serum sICAM-1 levels in patients with perennial allergic rhinitis are different from those in nonatopic healthy volunteers and whether immunotherapy can modulate sICAM-1 levels. Serum sICAM-1 was determined in 20 nonallergic volunteers and 137 patients with perennial allergic rhinitis by a sandwich enzyme-linked immunosorbent assay. Our study demonstrated that the level of sICAM-1 in untreated patients is significantly elevated, as compared with nonatopic subjects. Immunotherapy could decrease sICAM-1 in perennial allergic rhinitis, but this suppressive effect became apparent only after many years of immunotherapy. In patients on immunotherapy, a close correlation was observed between sICAM-1 and nasal symptom scores. To take these lines of evidence together, a decrease in sICAM-1 might be related to the working mechanism of immunotherapy, and serum sICAM-1 could be used to monitor the effect of immunotherapy.
Ohashi
Y
Y
Department of Otolaryngology, Osaka City University Medical School, Abeno, Osaka, Japan.
Nakai
Y
Y
Tanaka
A
A
Kakinoki
Y
Y
Ohno
Y
Y
Masamoto
T
T
Sakamoto
H
H
Kato
A
A
Washio
Y
Y
Hayashi
M
M
D000328:Adult; D015415:Biomarkers / Q000097:blood; D003888:Desensitization, Immunologic; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007167:Immunotherapy; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012221:Rhinitis, Allergic, Perennial / Q000097:blood* / Q000628:therapy; D013997:Time Factors; D016896:Treatment Outcome
D015415:Biomarkers; D018799:Intercellular Adhesion Molecule-1