title: The structures of the frenatin peptides from the skin secretion of the giant tree frog Litoria infrafrenata.
abstract: The granular dorsal glands of the giant tree frog Litoria infrafrenata contain five peptides including caerulein (a known neuropeptide), and four new peptides named franatins 1 (MH+ = 1140 Da), 2 (1423), 3 (2180), 4 (2493). The amino acid sequences of the frenatins are detailed: their structures do not correspond to those of peptides isolated from other amphibians or animals. Frenatin 3, Gly-Leu-Met-Ser-Val-Leu -Gly-His-Ala-Val-Gly-Asn-Val-Leu-Gly-Gly-Leu-Phe-Lys-Ser-(OH), has wide spectrum antimicrobial properties.
authors.affiliation: Department of Chemistry, University of Adelaide, South Australia.
authors.forename: M J
authors.initials: MJ
authors.lastname: Raftery
authors.forename: R J
authors.initials: RJ
authors.lastname: Waugh
authors.forename: J H
authors.initials: JH
authors.lastname: Bowie
authors.forename: J C
authors.initials: JC
authors.lastname: Wallace
authors.forename: M J
authors.initials: MJ
authors.lastname: Tyler
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001001:Anura / Q000378:metabolism*; D008969:Molecular Sequence Data; D010455:Peptides / Q000737:chemistry*; D012867:Skin / Q000378:metabolism*
chemical_list: D010455:Peptides