title: The Y chromosome in forensic analysis and paternity testing.
abstract: The male specificity of the human Y chromosome makes it potentially useful in forensic studies and paternity testing, and markers are now available which will allow its usefulness to be assessed in practice. However, while it can be used confidently for exclusions, the unusual properties of the Y mean that inclusions will be very difficult to make: haplotypes are confined within lineages, so population sub-structuring is a major problem, and many male relatives of a suspect will share his Y chromosome. Y haplotyping is most likely to find application in special instances, such as deficiency cases in paternity testing and in the analysis of mixtures of male and female DNA, or in combination with autosomal markers.
authors.affiliation: Department of Genetics, University of Leicester, UK. maj4@leicester.ac.uk
authors.forename: M A
authors.initials: MA
authors.lastname: Jobling
authors.forename: A
authors.initials: A
authors.lastname: Pandya
authors.forename: C
authors.initials: C
authors.lastname: Tyler-Smith
mesh_terms: D005260:Female; D005787:Gene Frequency / Q000235:genetics; D005819:Genetic Markers / Q000235:genetics*; D005828:Genetics, Population; D006239:Haplotypes; D006801:Humans; D008297:Male; D010334:Paternity; D011110:Polymorphism, Genetic / Q000235:genetics; D014998:Y Chromosome
chemical_list: D005819:Genetic Markers