title: Three-dimensional temperature control of palladium-nickel thermoseeds: a computer aided and experimental evaluation.
abstract: The capability of self-regulating thermoseeds to compensate for nonuniform cooling along their longitudinal axis has been investigated in this study. For this purpose a quasi three-dimensional computer model has been developed. Calculations of the temperature profile in tissue with nonuniform heat loss demonstrated a clear improvement in the longitudinal temperature control of PdNi seeds compared to constant power seeds. Further, two strategies for improved control of nonuniform cooling along the longitudinal axis of ferromagnetic seeds have been investigated: (1) application of a 'normal' undivided seed; and (2) division of a long seed in smaller segments of which each segment is able to respond more directly to local variations in the temperature distribution. Calculations with the quasi three-dimensional model showed that the loose segments do respond more directly to their close proximity. However, the equilibrium temperature of a segment in an area with high local blood flow will be relatively low due the limited heat production of PdNi thermoseeds. In the undivided seeds the high thermal conductivity of PdNi causes some levelling of the longitudinal temperature gradient in the seed. In addition, calorimetric experiments have shown that the heat production of a segmented seed is less effective because of a demagnetizing field. Also, the absence of PdNi between the segments reduces the heat production of the seed.
authors.affiliation: Department of Radiotherapy, University of Amsterdam, The Netherlands.
authors.forename: N
authors.initials: N
authors.lastname: van Wieringen
authors.forename: J D
authors.initials: JD
authors.lastname: van Dijk
authors.forename: J
authors.initials: J
authors.lastname: van Veldhuizen
authors.forename: G J
authors.initials: GJ
authors.lastname: Nieuwenhuys
mesh_terms: D000818:Animals; D001833:Body Temperature Regulation; D002151:Calorimetry; D003198:Computer Simulation; D005290:Ferric Compounds; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D008954:Models, Biological; D009369:Neoplasms / Q000503:physiopathology / Q000628:therapy; D009532:Nickel; D010165:Palladium; D013696:Temperature
chemical_list: D005290:Ferric Compounds; C001215:ferrite; D010165:Palladium; D009532:Nickel