Cytoarchitecture of the entorhinal cortex in schizophrenia.
OBJECTIVE
The purpose of this study was to determine whether schizophrenia is associated with abnormalities in neuronal migration in the entorhinal cortex.


METHODS
Nissl-stained sections through three cytoarchitectonic subdivisions of the entorhinal cortex were examined in postmortem brain specimens from 10 schizophrenic subjects and 10 matched normal comparison subjects.


RESULTS
No qualitative differences in cytoarchitecture were observed between the schizophrenic and comparison subjects.


CONCLUSIONS
These findings do not replicate previous reports of cytoarchitectural disturbances in the entorhinal cortex of schizophrenic subjects and thus fail to support the hypothesis of abnormal neuronal migration in schizophrenia.
Akil
M
M
Department of Psychiatry, University of Pittsburgh, PA 15213, USA.
Lewis
D A
DA
D018728:Entorhinal Cortex / Q000002:abnormalities / Q000033:anatomy & histology*; D006801:Humans; D009436:Neural Tube Defects / Q000473:pathology; D012559:Schizophrenia / Q000175:diagnosis* / Q000473:pathology