[Megakaryocytic thrombopenic purpura associated with enamel hypoplasia].
Patients with platelet disorders usually bleed into superficial sites such as the skin, mucous membranes, genitourinary tract and gastrointestinal tract caused by thrombocytopenia or thrombocyte dysfunction. Thrombocytopenia is caused by one of three mechanisms-decreased marrow production, increased splenic sequestration, or accelerated destruction of platelets. We report a 9-year-old male patient with thrombocytopenic purpura, dyserythropoetic anaemia, freckles on the skin and nanosomia, resembling Fanconi's (constitutional) anaemia. Although many patients with constitutional anaemia own other bony abnormalities, it was not found in this case. On the other hand, the patient showed enamel hypoplasia. To our knowledge, this association has never been reported before. Laboratory diagnosis, clinical findings, dental abnormalities and treatment are presented in details.
Alberth
M
M
Debreceni Orvostudományi Egyetem, Stomatologiai Klinika.
Nemes
J
J
Radics
T
T
Kiss
C
C
D000015:Abnormalities, Multiple; D002648:Child; D003744:Dental Enamel Hypoplasia / Q000150:complications* / Q000628:therapy; D004392:Dwarfism / Q000150:complications; D005199:Fanconi Anemia / Q000150:complications / Q000628:therapy; D006801:Humans; D008297:Male; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000150:complications* / Q000628:therapy