title: Cloning and characterization of a novel member of the human Mad gene family (MADH6).
abstract: MAD (mothers against decapentaplegic)-related proteins (MADRs) are intracellular components that play critical roles in signal-transduction pathways involving the transforming growth factor beta (TGFbeta) superfamily. Some Mad genes are candidates for tumor-suppressor functions. From a human fetal brain cDNA library we have isolated a novel Mad-related gene. Two alternatively transcribed mRNAs encode deduced 430- and 467-amino-acid peptides that showed high levels of similarity to MADR1/Smad1/hMAD1 (about 80% identity at the amino acid level). This gene, which we designated MADH6, resides on 13q12-q14 between BRCA2 and RB, a region that frequently displays loss of heterozygosity in breast, liver, and prostate cancers.
authors.affiliation: Otsuka GEN Research Institute, Otsuka Pharmaceutical Co., Ltd., Kawauchi-cho, Tokushima, Japan. watanabe@otsuka.genome.ad.jp
authors.forename: T K
authors.initials: TK
authors.lastname: Watanabe
authors.forename: M
authors.initials: M
authors.lastname: Suzuki
authors.forename: Y
authors.initials: Y
authors.lastname: Omori
authors.forename: H
authors.initials: H
authors.lastname: Hishigaki
authors.forename: M
authors.initials: M
authors.lastname: Horie
authors.forename: N
authors.initials: N
authors.lastname: Kanemoto
authors.forename: T
authors.initials: T
authors.lastname: Fujiwara
authors.forename: Y
authors.initials: Y
authors.lastname: Nakamura
authors.forename: E
authors.initials: E
authors.lastname: Takahashi
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002882:Chromosomes, Human, Pair 13; D003001:Cloning, Molecular; D018076:DNA, Complementary; D015870:Gene Expression; D006801:Humans; D008969:Molecular Sequence Data; D010455:Peptides; D011506:Proteins / Q000235:genetics*; D017422:Sequence Analysis, DNA; D017386:Sequence Homology, Amino Acid; D051904:Smad8 Protein; D014018:Tissue Distribution; D014157:Transcription Factors; D016212:Transforming Growth Factor beta / Q000235:genetics*
chemical_list: D018076:DNA, Complementary; D010455:Peptides; D011506:Proteins; C107514:SMAD9 protein, human; D051904:Smad8 Protein; D014157:Transcription Factors; D016212:Transforming Growth Factor beta