Modulation of kinase activities in dauers and in long-lived mutants of Caenorhabditis elegans.
Mutant alleles of the genes age-1 and daf-2 that lengthen life span (Age phenotype) of Caenorhabditis elegans cause higher protein kinase (PKA, PKC, PTK) activity levels in senescing worms relative to wild-type. Elevated levels of PKA and PTK were also present in dauer larvae, developmentally arrested juveniles specialized for long-term survival, relative to L3 larvae, the alternative developmental stage. PKC activity was downregulated in dauers of a non-Age control strain and in age-1 mutant dauers, compared to L3 larvae, but similar activities were measured in dauers and L3 larvae of a daf-2 mutant strain. Thus, age-1 and daf-2 mutant worms may express distinct elements of a dauer-specific survival program during adult life.
Vanfleteren
J R
JR
Department of Morphology, Systematics and Ecology, University of Ghent, Belgium.
De Vreese
A
A
D000483:Alleles; D000818:Animals; D017173:Caenorhabditis elegans / Q000235:genetics* / Q000254:growth & development / Q000378:metabolism*; D029742:Caenorhabditis elegans Proteins; D017868:Cyclic AMP-Dependent Protein Kinases / Q000378:metabolism; D015801:Helminth Proteins / Q000235:genetics; D007814:Larva / Q000378:metabolism; D008136:Longevity; D009154:Mutation; D019869:Phosphatidylinositol 3-Kinases; D010770:Phosphotransferases / Q000378:metabolism*; D011493:Protein Kinase C / Q000378:metabolism; D011494:Protein Kinases / Q000378:metabolism
D029742:Caenorhabditis elegans Proteins; D015801:Helminth Proteins; D010770:Phosphotransferases; D011494:Protein Kinases; D019869:Phosphatidylinositol 3-Kinases; C100662:AGE-1 protein, C elegans; D017868:Cyclic AMP-Dependent Protein Kinases; D011493:Protein Kinase C