title: Defective neutrophil function in workers occupationally exposed to hexachlorobenzene.
abstract: In this work we have studied the respiratory burst and chemotaxis of polymorphonuclear leukocytes from 51 workers exposed to chlorinated compounds, which were compared with those of non-exposed, age- and sex-matched individuals. These two neutrophil functions were significantly reduced as compared to controls. No correlation was observed between the length of exposure, hexachlorobenzene (HCB) blood concentrations and neutrophil chemotaxis or the extent of nitroblue tetrazolium reduction.
authors.affiliation: Department of Pharmacology/Hemocentre, F.C.M., State University of Campinas, Brazil.
authors.forename: M L
authors.initials: ML
authors.lastname: Queiroz
authors.forename: C
authors.initials: C
authors.lastname: Bincoletto
authors.forename: R C
authors.initials: RC
authors.lastname: Perlingeiro
authors.forename: C A
authors.initials: CA
authors.lastname: Souza
authors.forename: H
authors.initials: H
authors.lastname: Toledo
mesh_terms: D000328:Adult; D002634:Chemotaxis, Leukocyte / Q000187:drug effects; D006581:Hexachlorobenzene / Q000009:adverse effects* / Q000097:blood; D006801:Humans; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000187:drug effects / Q000502:physiology*; D009580:Nitroblue Tetrazolium; D016273:Occupational Exposure; D016897:Respiratory Burst / Q000187:drug effects
chemical_list: D009580:Nitroblue Tetrazolium; D006581:Hexachlorobenzene