[The effect of CO2 on conduction blocking in nerve fibers by trimecaine and anestezin].
It was shown in experiments on the sciatic nerve of the Rana ridibunda frog that CO2 promotes blocking of stimulation conduction in the nerve fibers by the tertiary amine trimecaine but does not change the rate of blocking by the neutral anesthetic anesthesin. The increased rate of trimecaine blockade development is explained by decrease of cytoplasmic pH under the effect of CO2, which leads to increase in the number of charged molecules of the anesthetic entering the sodium canal and blocking it.
Mangusheva
N A
NA
Katalymov
L L
LL
D000200:Action Potentials / Q000187:drug effects; D000779:Anesthetics, Local / Q000494:pharmacology*; D000818:Animals; D001566:Benzocaine / Q000494:pharmacology*; D002245:Carbon Dioxide / Q000494:pharmacology*; D004347:Drug Interactions; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D009412:Nerve Fibers / Q000187:drug effects* / Q000502:physiology; D009433:Neural Inhibition / Q000187:drug effects*; D011895:Rana ridibunda; D012584:Sciatic Nerve / Q000187:drug effects / Q000502:physiology; D014288:Trimecaine / Q000494:pharmacology*
D000779:Anesthetics, Local; C070909:anestezin; D002245:Carbon Dioxide; D014288:Trimecaine; D001566:Benzocaine