Magnesium sulphate improves neurologic outcome following severe closed head injury in rats.
While recent evidence suggests that brain intracellular free magnesium concentration declines following severe diffuse traumatic brain injury, no studies have examined whether magnesium administration following such injury can improve subsequent neurologic outcome. The present study shows that MgSO4 administered as a bolus at 30 min following severe closed head injury in rats significantly improves posttraumatic neurologic outcome as assessed by both rotarod and angleboard tests. Moreover, this improvement in outcome was evident with both intravenous and intramuscular drug administration. We conclude that parenteral administration of magnesium sulphate may be neuroprotective following severe closed head injury of a diffuse nature.
Heath
D L
DL
Department of Physiology and Pharmacology, James Cook University of North Queensland, Townsville, Australia.
Vink
R
R
D000818:Animals; D002491:Central Nervous System Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D016489:Head Injuries, Closed / Q000188:drug therapy* / Q000523:psychology; D007273:Injections, Intramuscular; D007275:Injections, Intravenous; D008278:Magnesium Sulfate / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D018696:Neuroprotective Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D004856:Postural Balance / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley
D002491:Central Nervous System Agents; D018696:Neuroprotective Agents; D008278:Magnesium Sulfate