title: Specific infection and destruction of dopaminergic neurons in the substantia nigra by Theiler's virus.
abstract: Theiler's murine encephalomyelitis virus was stereotaxically inoculated unilaterally into the substantia nigra of the mouse brain. Virus specifically infected tyrosine hydroxylase-positive neurons and spread rostrocaudally throughout this subpopulation of neurons, resulting in impaired function and degeneration of the substantia nigra. The spread of the virus to other areas of the brain was minimal and rare.
authors.affiliation: Department of Pathology, University of Cambridge, United Kingdom.
authors.forename: K R
authors.initials: KR
authors.lastname: Oliver
authors.forename: P
authors.initials: P
authors.lastname: Brennan
authors.forename: J K
authors.initials: JK
authors.lastname: Fazakerley
mesh_terms: D000818:Animals; D005260:Female; D051379:Mice; D008808:Mice, Inbred CBA; D012367:RNA, Viral / Q000032:analysis; D013378:Substantia Nigra / Q000473:pathology / Q000821:virology*; D017945:Theilovirus / Q000472:pathogenicity*; D014446:Tyrosine 3-Monooxygenase / Q000032:analysis
chemical_list: D012367:RNA, Viral; D014446:Tyrosine 3-Monooxygenase