title: Effects of ivermectin on Culex quinquefasciatus larvae.
abstract: The effects of ivermectin, a semi-synthetic drug widely used for treatment of livestock parasite diseases, were observed on Culex quinquefasciatus larvae. Toxic effects and mortality evaluation were carried out after 5, 15, 30 and 60 minutes of exposure to 1, 5 or 10 ppm of ivermectin solutions. Observations were made 24 and 48 hours after the beginning of the experiment, and loss of mobility, progressive paralysis and high mortality of larvae were recorded. The observed effects of ivermectin on the mosquito larvae is probably correlated with chloride channel activation on cell membranes.
authors.affiliation: Grupo Interdepartamental de Estudos sobre Esquistossomose (GIDE)/Departamento de Parasitologia, Universidade Federal de Minas Geraix, Belo Horizonte, Brasil.
authors.forename: R M
authors.initials: RM
authors.lastname: de Freitas
authors.forename: M de A
authors.initials: Mde A
authors.lastname: Faria
authors.forename: S N
authors.initials: SN
authors.lastname: Alves
authors.forename: A L
authors.initials: AL
authors.lastname: de Melo
mesh_terms: D000818:Animals; D003465:Culex / Q000187:drug effects*; D007303:Insect Vectors / Q000187:drug effects*; D007306:Insecticides / Q000633:toxicity*; D007559:Ivermectin / Q000633:toxicity*; D007814:Larva / Q000187:drug effects; D013997:Time Factors
chemical_list: D007306:Insecticides; D007559:Ivermectin