title: Low-grade gliomas of chronic epilepsy: a distinct clinical and pathological entity.
abstract: The authors present a summary of their recent experience regarding the management of patients with a variety of low-grade gliomas found during the evaluation for chronic epilepsy. These tumors are notable because the long-term patient outcome in this population is significantly better than the anticipated results of patients with the same tumors who do not have chronic epilepsy. Based on the long history of preoperative seizures (median 14 years), the frequent cortical location, and the absence of tumor recurrence or anaplastic transformation and the lack of mortality in this population, low-grade gliomas of chronic epilepsy appear to define a specific pathological entity that separates them from other histologically similar low-grade gliomas. Low-grade gliomas of chronic epilepsy also are notable for the absence of morphological features that characterize with dysembryoplastic neuroepithelial tumors (DNTs). Our evidence suggests that low-grade gliomas of chronic epilepsy should be recognized as a distinct pathological entity.
authors.affiliation: Yale University School of Medicine, Section of Neurosurgery, New Haven, CT 06520-8039, USA.
authors.forename: J C
authors.initials: JC
authors.lastname: Bartolomei
authors.forename: S
authors.initials: S
authors.lastname: Christopher
authors.forename: K
authors.initials: K
authors.lastname: Vives
authors.forename: D D
authors.initials: DD
authors.lastname: Spencer
authors.forename: J M
authors.initials: JM
authors.lastname: Piepmeier
mesh_terms: D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D001932:Brain Neoplasms / Q000150:complications* / Q000473:pathology* / Q000601:surgery; D002648:Child; D004827:Epilepsy / Q000145:classification / Q000150:complications* / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D005910:Glioma / Q000150:complications* / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008297:Male; D012189:Retrospective Studies