title: The hemolytic uremic syndrome presenting as bilateral leg ischemia.
abstract: The hemolytic uremic syndrome in adults is an uncommon clinical entity consisting of microangiopathic hemolytic anemia, thrombocytopenia, and renal dysfunction. A previously healthy 42-year-old man, after a 2-day prodromal phase, developed severe pain and coldness in both legs, with purpura in the face and extremities. On admission, hepatorenal dysfunction and disseminated intravascular coagulation were evident. These complicated signs and symptoms led to nonspecific supportive therapy because of delayed diagnosis. The patient's condition gradually improved except for ischemia of the legs, which progressed into symmetrical necrosis; eventually, bilateral below-knee amputation was required. This is the first reported case of the hemolytic uremic syndrome complicated by bilateral leg ischemia. A presumed cause of the ischemia was disseminated intravascular coagulation, a rare complication of the hemolytic uremic syndrome.
authors.affiliation: Department of Traumatology and Critical Care Medicine, National Defense Medical College, Saitama, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Takino
authors.forename: T
authors.initials: T
authors.lastname: Anada
authors.forename: Y
authors.initials: Y
authors.lastname: Okada
mesh_terms: D000328:Adult; D000671:Amputation, Surgical; D003131:Combined Modality Therapy; D006440:Hemofiltration; D006463:Hemolytic-Uremic Syndrome / Q000150:complications* / Q000628:therapy; D006801:Humans; D007511:Ischemia / Q000209:etiology* / Q000473:pathology / Q000628:therapy; D007866:Leg / Q000098:blood supply*; D008297:Male; D010951:Plasma Exchange