[Hyperbaric oxygenation and antiaggregants: effects on platelet function in patients with ischemic heart disease].
Platelet function (duration and percentage of aggregation and disaggregation) was studied in 65 chronic coronary patients over the course of hyperbaric oxygenation and antiaggregant therapy. A course of hyperbaric oxygenation (8 to 12 sessions at absolute atmosphere of 1.3-1.6 for 40 min) had no proaggregant or antiaggregant effects on the platelets in this category of patients. Aspirin in a daily dose of 125 mg and pentoxifylline in a daily dose of 300 mg reliably decreased the percentage of platelet aggregation and increased the share of disaggregation. Hyperbaric oxygenation in the above mode did not change the antiaggregant activity of these drugs.
Seriakov
V V
VV
Feofanova
I D
ID
D001241:Aspirin / Q000494:pharmacology / Q000627:therapeutic use; D001792:Blood Platelets / Q000187:drug effects / Q000502:physiology*; D003327:Coronary Disease / Q000097:blood / Q000188:drug therapy / Q000628:therapy*; D005260:Female; D006801:Humans; D006931:Hyperbaric Oxygenation; D008297:Male; D008875:Middle Aged; D010431:Pentoxifylline / Q000494:pharmacology / Q000627:therapeutic use; D010726:Phosphodiesterase Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D013997:Time Factors
D010726:Phosphodiesterase Inhibitors; D010975:Platelet Aggregation Inhibitors; D001241:Aspirin; D010431:Pentoxifylline