Character of structural disturbances caused by chloroalkylamines in the model and erythrocyte membranes.
beta, beta-Dichlorodiethylamine is proved not to induce structural disturbances in phosphatidylcholine liposomes and erythrocyte membranes which is registered by fluorescence methods. Methyl-beta, beta-dichlorodiethylamine and metaxylyl-beta, beta-dichlorodiethylamine cause the increase in microviscosity of lipid bilayer hydrophobic areas in both erythrocyte membranes and liposomes. Besides, polarity of the latter also decreases, and the metaxylyl derivative alkylates nucleophilic centers of phospholipid phosphate groups in liposomes. Erythrocyte membranes, being treated by beta, beta-dichlorodiethylamine derivatives, the increase in the membrane protein hydrophobicity is registered as well as the decrease in their immersion in the lipid bilayer.
Lebed
O I
OI
Institute of Pharmacology and Toxicology, Academy of Medical Sciences of Ukraine, Kyiv.
Zhirnov
V V
VV
Luik
A I
AI
Braver-Chernobulskaya
B S
BS
Yartsev
V G
VG
Kuzin
V G
VG
D018906:Antineoplastic Agents, Alkylating / Q000633:toxicity*; D002700:Chloramines / Q000633:toxicity; D004910:Erythrocyte Membrane / Q000187:drug effects*; D005456:Fluorescent Dyes; D006801:Humans; D008081:Liposomes; D008466:Mechlorethamine / Q000633:toxicity; D012995:Solubility; D014783:Viscosity; D014867:Water / Q000737:chemistry
D018906:Antineoplastic Agents, Alkylating; D002700:Chloramines; D005456:Fluorescent Dyes; D008081:Liposomes; D014867:Water; D008466:Mechlorethamine