title: Paramyosin: a candidate vaccine antigen against Schistosoma japonicum.
abstract: Paramyosin, a 97 kDa myofibrillar protein, is a candidate vaccine antigen for prevention of infection with the human parasite Schistosoma mansoni. To determine if paramyosin would also induce protection against Schistosoma japonicum, paramyosin was biochemically purified from S. japonicum adult worms. SDS-PAGE demonstrated a single protein with a molecular weight of 97 kDa. In four separate experiments, vaccination of mice with S. japonicum paramyosin without adjuvant induced significant resistance (62%-86%, P < 0.001) against cercarial challenge as compared to controls. These data suggest that S. japonicum paramyosin may represent a candidate vaccine for immunization against schistosomiasis japonica.
authors.affiliation: Research Institute for Tropical Medicine, Metro Manila, Philippines.
authors.forename: B L
authors.initials: BL
authors.lastname: Ramirez
authors.forename: J D
authors.initials: JD
authors.lastname: Kurtis
authors.forename: P M
authors.initials: PM
authors.lastname: Wiest
authors.forename: P
authors.initials: P
authors.lastname: Arias
authors.forename: F
authors.initials: F
authors.lastname: Aligui
authors.forename: L
authors.initials: L
authors.lastname: Acosta
authors.forename: P
authors.initials: P
authors.lastname: Peters
authors.forename: G R
authors.initials: GR
authors.lastname: Olds
mesh_terms: D000818:Animals; D000947:Antigens, Helminth / Q000008:administration & dosage / Q000302:isolation & purification*; D005260:Female; D015801:Helminth Proteins / Q000008:administration & dosage / Q000276:immunology / Q000302:isolation & purification; D006801:Humans; D007114:Immunization; D051379:Mice; D008813:Mice, Inbred ICR; D008970:Molecular Weight; D012549:Schistosoma japonicum / Q000276:immunology*; D012554:Schistosomiasis japonica / Q000276:immunology / Q000517:prevention & control; D014335:Tropomyosin / Q000008:administration & dosage / Q000276:immunology* / Q000302:isolation & purification*; D014612:Vaccines / Q000008:administration & dosage / Q000302:isolation & purification
chemical_list: D000947:Antigens, Helminth; D015801:Helminth Proteins; D014335:Tropomyosin; D014612:Vaccines