Drug interactions with the nonsedating antihistamines.
The nonsedating antihistamines are frequently prescribed agents. Well-documented drug-drug interactions with two of these agents, terfenadine and astemizole, may result in serious adverse effects, including death, when they are prescribed along with macrolide antibiotics and/or the antifungal agents itraconazole or ketoconazole. Fexofenadine and loratadine appear to be the least likely nonsedating antihistamines to interact with other medications and to result in a life-threatening interaction. This article reviews the known drug-drug interactions involving nonsedating antihistamines and provides a basis from which the clinician can predict potential interactions.
Ament
P W
PW
Latrobe Area Hospital, Pennsylvania, USA.
Paterson
A
A
D003577:Cytochrome P-450 Enzyme System / Q000187:drug effects; D004347:Drug Interactions; D011307:Drug Prescriptions; D006634:Histamine H1 Antagonists / Q000008:administration & dosage / Q000009:adverse effects* / Q000191:economics; D006801:Humans
D006634:Histamine H1 Antagonists; D003577:Cytochrome P-450 Enzyme System