[A method for stimulating the protective mechanisms of the gastric mucosa in peptic ulcer].
It was shown on an experimental model of chronic gastric ulcer in rats that administration of microsomal oxidation inductors benzonal (benzobarbital) and phenobarbital in a dose of 50 mg/kg for 10 days significantly increases the content of cytochrome P-450 in the gastric mucosa. The increased content of P-450 promotes stimulation of the synthesis of mucosal barrier glycoproteins. The cytoprotective effect of famotidine in a dose of 100 mg/kg and sucralfate in a dose of 400 mg/kg proved to be much weaker than that of the inductors.
Iakubov
A V
AV
Usmanov
R I
RI
Khakimov
Z Z
ZZ
D000818:Animals; D000897:Anti-Ulcer Agents / Q000627:therapeutic use; D001463:Barbiturates / Q000627:therapeutic use; D002908:Chronic Disease; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis / Q000187:drug effects; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D004790:Enzyme Induction / Q000187:drug effects; D015738:Famotidine / Q000627:therapeutic use; D005753:Gastric Mucosa / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D010634:Phenobarbital / Q000627:therapeutic use; D051381:Rats; D013268:Stimulation, Chemical; D013276:Stomach Ulcer / Q000188:drug therapy* / Q000201:enzymology; D013392:Sucralfate / Q000627:therapeutic use
D000897:Anti-Ulcer Agents; D001463:Barbiturates; D013392:Sucralfate; D015738:Famotidine; D003577:Cytochrome P-450 Enzyme System; C002915:benzobarbital; D010634:Phenobarbital