Endogenous CCK in the control of gastric emptying of glucose and maltose.
A role for endogenous cholecystokinin (CCK) in the control of gastric emptying of liquid glucose and maltose test meals in rhesus monkeys was assessed. Intragastric administration of a dose range (10-100 micrograms/kg) of the CCKA receptor antagonist devazepide produced a dose dependent acceleration of the emptying of 100 ml 300 mOsm test meals of glucose and maltose but had no effect on the emptying of a hyperosmotic (750 mOsm) NaCl solution. At the 100 micrograms/kg dose, the emptying of glucose and maltose meals were as rapid as the emptying of physiological NaCl. These data expand the demonstrated role of endogenous CCK in the slowing of gastric emptying of nutrients in rhesus monkeys to carbohydrates and suggest that previous negative results were due to the hyperosmotic nature of the glucose solutions.
Moran
T H
TH
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. tmoran@welchlink.welch.jhu.edu
Field
D G
DG
Knipp
S
S
Carrigan
T S
TS
Schwartz
G J
GJ
D000818:Animals; D001570:Benzodiazepinones / Q000494:pharmacology; D002766:Cholecystokinin / Q000037:antagonists & inhibitors / Q000502:physiology*; D020109:Devazepide; D004305:Dose-Response Relationship, Drug; D005746:Gastric Emptying / Q000502:physiology*; D005947:Glucose / Q000378:metabolism*; D006727:Hormone Antagonists / Q000494:pharmacology; D008253:Macaca mulatta; D008297:Male; D008320:Maltose / Q000378:metabolism*; D009994:Osmolar Concentration
D001570:Benzodiazepinones; D006727:Hormone Antagonists; D008320:Maltose; D002766:Cholecystokinin; D005947:Glucose; D020109:Devazepide