title: Indicators of fatal outcome in paediatric cerebral malaria: a study of 134 comatose Papua New Guinean children.
abstract: BACKGROUND
  No comprehensive data on the clinical features and the prognosis of cerebral malaria in the South Pacific are available at present. We conducted a prospective study in children with cerebral malaria to assess the case fatality rate (CFR) in the region and to identify potential risk factors for death.
  
  
  METHODS
  We recruited 134 children admitted to the Madang General Hospital between April 1991 and October 1993 with a strictly defined diagnosis of cerebral malaria. Besides clinical examination, we collected a blood sample for parasitological haematological and biochemical assessment.
  
  
  RESULTS
  The CFR was 11.9% and the prevalence of residual neurological sequelae at discharge was 1.5%. The proportion of children presenting with deep coma (12%) or hypoglycaemia (17%) was lower in our study than in African ones, where severe complications are more frequent. Also mortality associated with hypoglycaemia on admission was lower. Clinical or laboratory conditions significantly associated with death were deep coma, malarial anaemia and hyperleucocytosis.
  
  
  CONCLUSIONS
  All conditions associated with deep coma, such as shock, hypoglycaemia and acidosis, should be corrected. Also prompt administration of blood transfusions to patients with anaemia is likely to reduce the occurrence of death in Papua New Guinean children with cerebral malaria.
authors.affiliation: Papua New Guinea Institute of Medical Research, Madang, Papua New Guinea.
authors.forename: B
authors.initials: B
authors.lastname: Genton
authors.forename: F
authors.initials: F
authors.lastname: al-Yaman
authors.forename: M P
authors.initials: MP
authors.lastname: Alpers
authors.forename: D
authors.initials: D
authors.lastname: Mokela
mesh_terms: D002648:Child; D002675:Child, Preschool; D003128:Coma / Q000209:etiology / Q000401:mortality; D016001:Confidence Intervals; D003430:Cross-Sectional Studies; D005260:Female; D006400:Hematocrit / Q000706:statistics & numerical data; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D007223:Infant; D007958:Leukocyte Count; D016013:Likelihood Functions; D016015:Logistic Models; D016779:Malaria, Cerebral / Q000097:blood / Q000150:complications / Q000401:mortality* / Q000503:physiopathology; D008297:Male; D016017:Odds Ratio; D010219:Papua New Guinea / Q000453:epidemiology; D015995:Prevalence; D011446:Prospective Studies; D012720:Severity of Illness Index
chemical_list: D006454:Hemoglobins