In vivo target-specific delivery of macromolecular agents with MR-guided focused ultrasound.
Magnetic resonance (MR) images in rabbit muscle were used to select a target region for application of pulsed-focused ultrasound. Liposomes encapsulating gadopentetate dimeglumine, an MR-detectable model representing pharmaceutical agents, were then injected intravenously. Focal enhancement on T1-weighted images, representing gadolinium-liposome accumulation, occurred in the pulsed-focused-ultrasound focal zone. Therefore, MR-guided pulsed-focused ultrasound targeted the delivery of macromolecular pharmaceutical agents within tissues.
Bednarski
M D
MD
Department of Radiology, Stanford University School of Medicine, CA 94305, USA.
Lee
J W
JW
Callstrom
M R
MR
Li
K C
KC
D000818:Animals; D002199:Capillary Permeability; D003287:Contrast Media / Q000008:administration & dosage*; D004337:Drug Carriers; D004338:Drug Combinations; D016503:Drug Delivery Systems / Q000379:methods*; D019786:Gadolinium DTPA; D007089:Image Enhancement / Q000379:methods*; D008081:Liposomes; D046911:Macromolecular Substances; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008536:Meglumine / Q000008:administration & dosage*; D017348:Microscopy, Electron, Scanning Transmission; D009942:Organometallic Compounds / Q000008:administration & dosage*; D004369:Pentetic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives*; D011817:Rabbits; D011897:Random Allocation; D014464:Ultrasonic Therapy / Q000379:methods*; D018617:Ultrasonography, Doppler, Pulsed / Q000379:methods*
D003287:Contrast Media; D004337:Drug Carriers; D004338:Drug Combinations; D008081:Liposomes; D046911:Macromolecular Substances; D009942:Organometallic Compounds; D008536:Meglumine; D004369:Pentetic Acid; D019786:Gadolinium DTPA