Physicians' knowledge of antidepressant withdrawal effects: a survey.
BACKGROUND
While the incidence of discontinuation events in controlled studies of serotonin reuptake inhibitors ranges between 34.5% and 86%, only a small number of discontinuation reactions are reported to national data bases of spontaneously reported adverse drug reactions. It was hypothesized that the disparity was due to lack of knowledge amongst physicians about the potential for antidepressant discontinuation reactions.


METHODS
Therefore, a questionnaire was mailed to 100 psychiatrists and 100 general practitioners (GPs) in northeast England to assess the knowledge base and to validate this assumption.


RESULTS
Fifty psychiatrists (50%) and 53 GPs (53%) responded to the questionnaire. Of the respondents, 36 (72%) of the psychiatrists and 16 (30%) of the GPs were aware that patients may experience antidepressant discontinuation events; 33 (66%) psychiatrists and 22 (42%) GPs had had experience with patients who had discontinuation symptoms; and 10 (20%) psychiatrists and 9 (17%) GPs said they always caution patients about the possibility of discontinuations events.


CONCLUSIONS
According to the results of the survey, a sizable minority of physicians denied being confidently aware of the existence of antidepressant withdrawal symptoms. Education about discontinuation reactions, including the hallmark features, symptoms, and course, is needed for both psychiatrists and family practice physicians.
Young
A H
AH
Hadrian Clinic, Newcastle General Hospital, Newcastle Upon Tyne, UK.
Currie
A
A
D016907:Adverse Drug Reaction Reporting Systems; D000928:Antidepressive Agents / Q000009:adverse effects*; D001291:Attitude of Health Personnel; D002983:Clinical Competence; D003866:Depressive Disorder / Q000188:drug therapy; D004502:Education, Medical, Continuing; D004739:England; D005194:Family Practice; D006801:Humans; D011570:Psychiatry; D013375:Substance Withdrawal Syndrome / Q000175:diagnosis / Q000209:etiology*; D011795:Surveys and Questionnaires
D000928:Antidepressive Agents