[Peptide binding motif for HLA class I and autoimmune disease].
Some HLA class I alleles are strongly associated with autoimmune diseases, such as HLA-B27 for ankylosing spondylitis (AS), and HLA-B51 for Behçet's disease. But it is not clear how the class I molecules play a role in induction of the diseases. Recent studies have shown that HLA class I associates with beta 2-microglobulin and one of a range of naturally processed short peptides. The peptides bind into a groove formed by two alpha helices and a beta-pleated sheet of HLA class I molecules. HLA class I molecules present peptides with allele-specific motifs to T cells, and CTL recognize the peptides on HLA class I molecules. Further studies of peptides bound to HLA class I molecules are expected to identify peptides associated with autoimmune disease.
Sakaguchi
T
T
Department of Tumor Biology, University of Tokyo.
Takiguchi
M
M
D000595:Amino Acid Sequence; D000818:Animals; D001327:Autoimmune Diseases / Q000209:etiology; D015796:HLA-B27 Antigen / Q000378:metabolism; D015395:Histocompatibility Antigens Class I / Q000378:metabolism; D006801:Humans; D008969:Molecular Sequence Data; D010455:Peptides / Q000378:metabolism
D015796:HLA-B27 Antigen; D015395:Histocompatibility Antigens Class I; D010455:Peptides