Portal vein thrombosis in association with factor V Leiden mutation in a patient with hepatocellular carcinoma.
We report a case of hepatocellular carcinoma associated with portal vein thrombosis. Analysis of whole cellular DNA demonstrated heterozygosity for the factor V Leiden mutation. The patient also had marked protein C deficiency. The presence of the mutation associated with protein C deficiency may increase the risk of thrombosis in this patient with hepatocellular carcinoma.
Gürgey
A
A
Department of Pediatrics, Hacettepe University, Ihsan Dogramaci Children Hospital, Ankara, Turkey.
Büyükpamukcu
M
M
Baskut
C
C
Yalcin
B
B
Gögüş
S
S
D006528:Carcinoma, Hepatocellular / Q000150:complications* / Q000235:genetics; D002648:Child; D004273:DNA, Neoplasm / Q000235:genetics; D005165:Factor V / Q000235:genetics*; D006579:Heterozygote; D006801:Humans; D008113:Liver Neoplasms / Q000150:complications* / Q000235:genetics; D008297:Male; D009154:Mutation / Q000235:genetics*; D011169:Portal Vein / Q000473:pathology*; D020151:Protein C Deficiency; D013927:Thrombosis / Q000097:blood / Q000209:etiology* / Q000235:genetics
D004273:DNA, Neoplasm; C095381:factor V Leiden; D005165:Factor V