title: Therapeutic drug monitoring of risperidone and 9-hydroxyrisperidone in serum with solid-phase extraction and high-performance liquid chromatography.
abstract: This laboratory developed a simple and efficient solid-phase extraction method that is combined with high-performance liquid chromatography for rapid and precise therapeutic monitoring of risperidone (Risperdal) in blood concentrations. The solid-phase extraction uses a mixed bed column. Sensitivity of the chromatographic method is 0.5 ng/ml (180 pmol/ml) of drug in serum, and separations can be performed in a 15-minute chromatographic run. Advantages of this approach include enhanced speed, sensitivity, and efficiency. A high level of sensitivity may be achieved because of the absence of interference from other drugs, metabolites, or serum components.
authors.affiliation: Neurochemistry Laboratory, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, USA.
authors.forename: M C
authors.initials: MC
authors.lastname: Price
authors.forename: D W
authors.initials: DW
authors.lastname: Hoffman
mesh_terms: D014150:Antipsychotic Agents / Q000097:blood*; D002851:Chromatography, High Pressure Liquid; D016903:Drug Monitoring; D006801:Humans; D007555:Isoxazoles / Q000097:blood*; D000068882:Paliperidone Palmitate; D011743:Pyrimidines / Q000097:blood*; D018967:Risperidone / Q000097:blood*
chemical_list: D014150:Antipsychotic Agents; D007555:Isoxazoles; D011743:Pyrimidines; D018967:Risperidone; D000068882:Paliperidone Palmitate