Resolution of paraneoplastic bile duct paucity following successful treatment of Hodgkin's disease.
We report the case of a 21-year-old woman who developed severe adult onset ductopenia in association with Hodgkin's lymphoma. Chemotherapy resulted in a remission of her Hodgkin's disease (HD) and significant improvement in liver function with resolution of the hepatic and biliary duct histological abnormalities, a therapeutic success not previously described in the literature.
Crosbie
O M
OM
Liver Unit, St. Vincent's Hospital, Elm Park, Dublin, Ireland.
Crown
J P
JP
Nolan
N P
NP
Murray
R
R
Hegarty
J E
JE
D000328:Adult; D000469:Alkaline Phosphatase / Q000097:blood; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001649:Bile Duct Diseases / Q000150:complications* / Q000473:pathology; D001663:Bilirubin / Q000097:blood; D001706:Biopsy; D005260:Female; D006689:Hodgkin Disease / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D008466:Mechlorethamine / Q000008:administration & dosage; D011344:Procarbazine / Q000008:administration & dosage; D014750:Vincristine / Q000008:administration & dosage; D005723:gamma-Glutamyltransferase / Q000097:blood
D011344:Procarbazine; D008466:Mechlorethamine; D014750:Vincristine; D005723:gamma-Glutamyltransferase; D000469:Alkaline Phosphatase; D001663:Bilirubin