[Ritanserin prolongs the analgesic effect of morphine and slows the development of tolerance].
The effect of 5-HT2 receptor blocker ritanserine on the analgesic effect of morphine was studied in experiments on mice. A single simultaneous injection of ritanserine (10 mg/kg) and morphine (1, 10, and 20 mg/kg) prolonged the duration of analgesia in the tail clip test. Combined subchronic (6 days) injection of morphine and ritanserine (1, 5, and 10 mg/kg) twice a day delayed the development of tolerance to the opiate analgesic effect in the hot plate and tail clip tests.
Verbitskaia
E V
EV
Kudriashova
M F
MF
D000701:Analgesics, Opioid / Q000494:pharmacology*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D004361:Drug Tolerance; D008297:Male; D051379:Mice; D009020:Morphine / Q000494:pharmacology*; D010146:Pain / Q000503:physiopathology; D011930:Reaction Time / Q000187:drug effects; D016713:Ritanserin / Q000008:administration & dosage / Q000494:pharmacology*; D012702:Serotonin Antagonists / Q000008:administration & dosage / Q000494:pharmacology*; D013997:Time Factors
D000701:Analgesics, Opioid; D012702:Serotonin Antagonists; D016713:Ritanserin; D009020:Morphine