gamma-Pyrones from Gonystylus keithii, as new inhibitors of parathyroid hormone (PTH)-induced Ca release from neonatal mouse calvaria.
New gamma-pyrones, 9'-oxopodopyrone (3) and 8-methyl-9'-oxopodopyrone (4) were isolated from the leaves of Gonystylus keithii, along with known gamma-pyrones, 10'-oxopodopyrone (1) and 8-methyl-10'-oxopodopyrone (2). These gamma-pyrones markedly inhibited the bovine parathyroid hormone (PTH)-induced Ca release from neonatal mouse calvaria in vitro. It is the first time that gamma-pyrones showed inhibitory effects on bone resorption, and these compounds may be seed compounds of new drugs for osteoporosis.
Kanazawa
T
T
Bio-Medical Division, Sumitomo Metal Industries, Ltd., Kyoto, Japan.
Ohkawa
Y
Y
Kuda
T
T
Minobe
Y
Y
Tani
T
T
Nishizawa
M
M
D000818:Animals; D001862:Bone Resorption; D001842:Bone and Bones / Q000187:drug effects / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism*; D002417:Cattle; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008956:Models, Chemical; D010024:Osteoporosis / Q000188:drug therapy; D010281:Parathyroid Hormone / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal; D011753:Pyrones / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D012886:Skull / Q000187:drug effects / Q000378:metabolism
D010281:Parathyroid Hormone; D011753:Pyrones; D002118:Calcium