Platelet 5-HT levels and hypothalamic-pituitary-adrenal axis activity in schizophrenic patients with positive and negative symptoms.
Hypothalamic-pituitary-adrenal (HPA) axis activity and platelet 5-HT concentrations were determined before dexamethasone suppression test (DST) in 80 male schizophrenic patients with predominantly positive or negative symptoms. Significant differences in platelet 5-HT and no differences in baseline plasma cortisol concentrations among schizophrenic suppressors and nonsuppressors were found. A similar rate of nonsuppression (56% positive and 53% negative schizophrenic patients) was detected. Platelet 5-HT, but not plasma cortisol concentrations, could be used to differentiate positive and negative symptoms of schizophrenia.
Pivac
N
N
Laboratory for Molecular Neuropharmacology, Ruder Bosković Institute, Zagreb, Croatia. Npivac@olimp.irb.hr
Mück-Seler
D
D
Jakovljević
M
M
D000328:Adult; D001143:Arousal / Q000502:physiology; D001792:Blood Platelets / Q000378:metabolism*; D003702:Delusions / Q000175:diagnosis / Q000503:physiopathology / Q000523:psychology; D003863:Depression / Q000175:diagnosis / Q000503:physiopathology / Q000523:psychology; D003907:Dexamethasone; D003937:Diagnosis, Differential; D006212:Hallucinations / Q000175:diagnosis / Q000503:physiopathology / Q000523:psychology; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology*; D008297:Male; D010913:Pituitary-Adrenal System / Q000503:physiopathology*; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000175:diagnosis / Q000503:physiopathology*; D012565:Schizophrenic Psychology; D012701:Serotonin / Q000097:blood*
D012701:Serotonin; D003907:Dexamethasone; D006854:Hydrocortisone