Effects of fluoxetine on the immunosuppressive response to stress in mice.
Mice exposed to a chronic auditory stressor and treated with fluoxetine (5 mg/kg) showed a reduction in stress-induced suppression of thymus and spleen cellularity, and in peripheral T lymphocyte population. The blastogenic response of spleen lymphoid cells and the delayed type hypersensitivity response (DTH) to sheep red blood cells (SRBC) were also assessed and fluoxetine was found to partially reverse the inhibitory effect of stress on both parameters.
Freire-Garabal
M
M
Department of Pharmacology, University of Santiago de Compostela, Spain.
Nuñez
M J
MJ
Losada
C
C
Pereiro
D
D
Riveiro
M P
MP
González-Patiño
E
E
Mayán
J M
JM
Rey-Mendez
M
M
D000818:Animals; D002452:Cell Count / Q000187:drug effects*; D005260:Female; D005473:Fluoxetine / Q000494:pharmacology*; D007165:Immunosuppression Therapy; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D013154:Spleen / Q000187:drug effects; D013312:Stress, Physiological / Q000188:drug therapy*; D013601:T-Lymphocytes / Q000187:drug effects*; D013950:Thymus Gland / Q000187:drug effects
D005473:Fluoxetine