Apoptosis to HL-60 by humulone.
Humulone, a bone resorption inhibitor isolated from hop extract, induced apoptosis in the premyocytic leukemia cell line HL-60 between 1 and 100 micrograms/ml. Our data suggested that there was a correlation between the apoptosis-inducing activity of humulone and its antioxidative activity.
Tobe
H
H
Showa College of Pharmaceutical Sciences, Tokyo, Japan.
Kubota
M
M
Yamaguchi
M
M
Kocha
T
T
Aoyagi
T
T
D000890:Anti-Infective Agents / Q000494:pharmacology*; D016588:Anticarcinogenic Agents / Q000633:toxicity; D000975:Antioxidants / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects* / Q000235:genetics; D001205:Ascorbic Acid / Q000494:pharmacology; D001862:Bone Resorption / Q000517:prevention & control*; D002455:Cell Division / Q000187:drug effects; D053138:Cyclohexenes; D053938:DNA Fragmentation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D019833:Genistein; D018922:HL-60 Cells / Q000166:cytology / Q000187:drug effects*; D006801:Humans; D007529:Isoflavones / Q000494:pharmacology; D007928:Lethal Dose 50; D011794:Quercetin / Q000494:pharmacology; D013729:Terpenes / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D000890:Anti-Infective Agents; D016588:Anticarcinogenic Agents; D000975:Antioxidants; D053138:Cyclohexenes; D007529:Isoflavones; D013729:Terpenes; D011794:Quercetin; D019833:Genistein; C007966:humulon; D001205:Ascorbic Acid