title: Treatment of lethal midline granuloma type nasal T-cell lymphoma.
abstract: Nasal T-cell lymphoma of the LMG type (LMG-NTL) is characterized by progressive, unrelenting ulceration, and necrosis of the nasal cavity and midline facial tissues. The clinical behavior of this tumor in 16 patients is compared with that of a nasal lymphoma of non-LMG-NTL type (non-LMG-NTL) in 8 patients and a paranasal sinus lymphoma (PSL) in 6 patients. All patients had stage I or II disease. Fourteen of the 16 patients with LMG-NTL received chemotherapy before and/or after radiotherapy. Cause-specific 5-year survival rates for patients with LMG-NTL, non-LMG-NTL, and PSL were 22%, 75%, and 67% respectively. Seven patients with LMG-NTL, had complete response, although 3 recurred, whereas it was incomplete in 9 patients. The data indicates that it is desirable to deliver 50 Gy or more to achieve in-field control of LMG-NTL.
authors.affiliation: Department of Radiology, Sapporo Medical University, School of Medicine, Chuo-Ku, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Sakata
authors.forename: M
authors.initials: M
authors.lastname: Hareyama
authors.forename: A
authors.initials: A
authors.lastname: Ohuchi
authors.forename: M
authors.initials: M
authors.lastname: Sido
authors.forename: H
authors.initials: H
authors.lastname: Nagakura
authors.forename: K
authors.initials: K
authors.lastname: Morita
authors.forename: Y
authors.initials: Y
authors.lastname: Harabuchi
authors.forename: A
authors.initials: A
authors.lastname: Kataura
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D006103:Granuloma, Lethal Midline / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy*; D006801:Humans; D016399:Lymphoma, T-Cell / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy*; D008297:Male; D008875:Middle Aged; D009669:Nose Neoplasms / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy*; D009626:Terminology as Topic