title: Thyroid dysfunction is not associated with alterations in serum leptin levels.
abstract: To determine if serum leptin levels are affected by thyroid dysfunction, we measured its concentration in serum samples from 25 euthyroid controls and 25 subjects each with hypothyroidism and thyrotoxicosis collected over a 3-month period. Mean leptin levels in the euthyroid (24.1 +/- 8.3 microg/L), hypothyroid (22.7 +/- 7.0 microg/L) and thyrotoxic (23.3 +/- 4.3 microg/L) groups were not significantly different. Data were available to express leptin in terms of body mass index (BMI) in 11 euthyroid, and 6 untreated hypothyroid and thyrotoxic individuals. There was a significant positive correlation between BMI and leptin level (r = 0.60, p = .0002) for this subgroup, irrespective of their thyroid status. These data suggest that leptin levels are not affected by thyroid dysfunction.
authors.affiliation: Department of Medicine, The University of Chicago and Pritzker School of Medicine, Illinois 60637, USA.
authors.forename: S
authors.initials: S
authors.lastname: Sreenan
authors.forename: J F
authors.initials: JF
authors.lastname: Caro
authors.forename: S
authors.initials: S
authors.lastname: Refetoff
mesh_terms: D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000097:blood / Q000503:physiopathology; D020738:Leptin; D008297:Male; D008875:Middle Aged; D011506:Proteins / Q000378:metabolism*; D013959:Thyroid Diseases / Q000097:blood / Q000503:physiopathology*; D013960:Thyroid Function Tests; D013971:Thyrotoxicosis / Q000097:blood / Q000503:physiopathology; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood
chemical_list: D020738:Leptin; D011506:Proteins; D013972:Thyrotropin; D013974:Thyroxine