[Immunomorphologic characterization of various parameters of stomach cancer invasion].
25 cases of advanced stomach carcinoma were studied immunomorphologically with the use of the antibodies panel to the carcinoembryonic antigen and meconian antigen B1, collagen types IV, I and III, laminin, Ki-67, P-105, factor VIII. Secretory and proliferative activity of tumor cells was shown unrelated to histological structure and degree of tumor differentiation. The more was proliferative activity the weaker was the secretory function. Formation of the basal membrane (BM), the degree of collagen formation and angiogenesis in the tubular adenocarcinoma did not depend on the differentiation level and the degree of tumor cells secretory activity. On the contrary, carcinoid component was characterized by pronounced angiogenesis and tendency to correlation between the degree of differentiation and the degree of BM formation. Stomach carcinoma is a heterogeneous group of tumors whose various morphological features may have an independent prognostic value.
Frank
G A
GA
Litvinova
L V
LV
Belous
T A
TA
Pugachev
K K
KK
D014408:Biomarkers, Tumor / Q000276:immunology*; D002272:Carcinoembryonic Antigen / Q000032:analysis; D002454:Cell Differentiation / Q000502:physiology; D002455:Cell Division / Q000502:physiology; D003094:Collagen / Q000276:immunology; D005169:Factor VIII / Q000276:immunology; D005455:Fluorescent Antibody Technique; D006651:Histocytochemistry; D006801:Humans; D019394:Ki-67 Antigen / Q000032:analysis; D007797:Laminin / Q000276:immunology; D009361:Neoplasm Invasiveness; D011379:Prognosis; D013274:Stomach Neoplasms / Q000276:immunology / Q000473:pathology*
D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen; D019394:Ki-67 Antigen; D007797:Laminin; D005169:Factor VIII; D003094:Collagen