[The effect of solar ultraviolet on the system of microorganisms-higher plant antibiotics, a natural phenomenon and a new approach to enhancing the efficacy of antibiotics].
Under the effect of solar radiation some antibiotics of plant origin (phenylheptatriin, bakuchiol and others) showed antimicrobial phototoxicity differing by the spectrum and activity from the antibiotic action. The highest in vitro antimicrobial phototoxicity was observed with polyacetylene phenylheptatriin: the activation effect of solar radiation on it was due to UV-A and developed in gaseous phase or to a lesser extent in dispersed liquid phase. For comparison, 18 currently used antibiotics of various chemical structure were investigated and no phototoxicity under the effect of solar radiation with respect to the tested microbes was detected. In nature the phenomenon of antimicrobial phototoxicity of plant secondary metabolites due to the effect of solar radiation is probably of large scale. The study of the phenomenon is a new trend in biology (plant antibiotics and phytoncides, phytoimmunity, ecological and evolutionary microbiology, etc.) and a new approach to increase the efficacy of some antibiotics and to develop principally novel photochemotherapeutics for the treatment of infections in humans, animals and plants.
Smirnov
V V
VV
Bondarenko
A S
AS
Evseenko
O V
OV
D000935:Antifungal Agents / Q000302:isolation & purification / Q000494:pharmacology / Q000528:radiation effects*; D003470:Culture Media; D005658:Fungi / Q000187:drug effects / Q000528:radiation effects*; D008826:Microbial Sensitivity Tests; D010946:Plants, Medicinal; D014455:Ukraine; D014466:Ultraviolet Rays
D000935:Antifungal Agents; D003470:Culture Media