Antiviral activity of 5,6,7-trimethoxyflavone and its potentiation of the antiherpes activity of acyclovir.
A naturally occurring flavone, 5,6,7-trimethoxyflavone (TMF), isolated from the plant Callicarpa japonica, was subjected to antiviral assays. The compound exhibited relatively high inhibitory effects on herpes simplex virus type 1 (HSV-1), human cytomegalovirus and poliovirus. The anti-HSV-1 action was not due to the inhibition of virus adsorption, entry and viral protein synthesis, but might involve, at least in part, a virucidal activity, which results in a suppression of viral binding to host cells at an early replication stage. TMF and acylovir were synergic in their anti-HSV activities at levels below the 50% inhibitory concentrations for antiviral activity.
Hayashi
K
K
Department of Virology, Toyama Medical and Pharmaceutical University, Sugitani, Japan.
Hayashi
T
T
Otsuka
H
H
Takeda
Y
Y
D000212:Acyclovir / Q000494:pharmacology*; D000998:Antiviral Agents / Q000494:pharmacology*; D018929:Cell Culture Techniques; D003587:Cytomegalovirus / Q000187:drug effects*; D004357:Drug Synergism; D005347:Fibroblasts / Q000187:drug effects; D005419:Flavonoids / Q000494:pharmacology*; D018259:Herpesvirus 1, Human / Q000187:drug effects*; D006801:Humans; D008168:Lung / Q000187:drug effects / Q000378:metabolism; D017955:Poliovirus / Q000187:drug effects*; D014779:Virus Replication / Q000187:drug effects*
C107364:5,6,7-trimethoxyflavone; D000998:Antiviral Agents; D005419:Flavonoids; D000212:Acyclovir