title: Diffuse pulmonary amyloidosis with monoclonal IgG-kappa gammopathy.
abstract: A 62-year-old female with diffuse pulmonary amyloidosis developed abnormal radiographic findings while under observation for hyperimmunoglobulinemia over a ten-year period. Serum immunoglobulin G (IgG) was elevated (4,620 mg/dl), and associated with monoclonal gammopathy (M protein) of the kappa type, but no evident abnormalities were apparent in bone marrow. Chest radiograph and computed tomography showed a diffuse reticulonodular shadow in the bilateral lung. Thoracoscopic lung biopsy specimen revealed depositions of amyloid in the bronchus and pulmonary vessel. We emphasize that diffuse pulmonary amyloidosis should be considered a possible diagnosis in the presence of monoclonal immunoglobulin.
authors.affiliation: First Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto.
authors.forename: S
authors.initials: S
authors.lastname: Takashi
authors.forename: T
authors.initials: T
authors.lastname: Koizumi
authors.forename: Y
authors.initials: Y
authors.lastname: Yamazaki
authors.forename: M
authors.initials: M
authors.lastname: Hayasaka
authors.forename: K
authors.initials: K
authors.lastname: Kubo
authors.forename: M
authors.initials: M
authors.lastname: Sekiguchi
authors.forename: T
authors.initials: T
authors.lastname: Honda
mesh_terms: D000686:Amyloidosis / Q000150:complications* / Q000175:diagnosis; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D007145:Immunoglobulin kappa-Chains / Q000097:blood*; D008171:Lung Diseases / Q000150:complications* / Q000175:diagnosis; D008875:Middle Aged; D010265:Paraproteinemias / Q000150:complications* / Q000276:immunology
chemical_list: D007074:Immunoglobulin G; D007145:Immunoglobulin kappa-Chains