title: A high ratio of insulin-like growth factor II/insulin-like growth factor binding protein 2 messenger RNA as a marker for anaplasia in meningiomas.
abstract: Insulin-like growth factors (IGFs) I and II have been implicated as autocrine or paracrine growth promoters. These growth factors bind to specific receptors, and the response is modulated by interaction with IGF-binding proteins (IGFBPs). We observed a strong correlation between anaplastic/atypical histopathology and a high IGF-II/IGFBP-2 mRNA ratio in a set of 68 sporadic meningiomas. A strong correlation was also found between clinical outcome and IGF-II/IGFBP-2 ratio, whereas previously used histochemical markers were less correlated to outcome. We suggest that a high IGF-II/IGFBP-2 mRNA ratio may be a sign of biologically aggressive behavior in meningiomas that can influence treatment strategies. We propose that low IGFBP-2 levels in combination with increased levels of IGF-II would result in more free IGF-II and consequently greater stimulation of proliferation.
authors.affiliation: Department of Molecular Medicine, Karolinska Hospital, Stockholm, Sweden.
authors.forename: A C
authors.initials: AC
authors.lastname: Nordqvist
authors.forename: M
authors.initials: M
authors.lastname: Peyrard
authors.forename: H
authors.initials: H
authors.lastname: Pettersson
authors.forename: T
authors.initials: T
authors.lastname: Mathiesen
authors.forename: V P
authors.initials: VP
authors.lastname: Collins
authors.forename: J P
authors.initials: JP
authors.lastname: Dumanski
authors.forename: M
authors.initials: M
authors.lastname: Schalling
mesh_terms: D000328:Adult; D000368:Aged; D000708:Anaplasia / Q000378:metabolism* / Q000473:pathology; D015152:Blotting, Northern; D001932:Brain Neoplasms / Q000378:metabolism* / Q000473:pathology; D002872:Chromosome Deletion; D002892:Chromosomes, Human, Pair 22 / Q000235:genetics; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D018971:Insulin-Like Growth Factor Binding Protein 2 / Q000235:genetics / Q000378:metabolism*; D007335:Insulin-Like Growth Factor II / Q000235:genetics / Q000378:metabolism*; D019394:Ki-67 Antigen / Q000378:metabolism; D008297:Male; D008579:Meningioma / Q000378:metabolism* / Q000473:pathology; D008875:Middle Aged; D012333:RNA, Messenger / Q000378:metabolism; D011980:Receptors, Progesterone / Q000378:metabolism
chemical_list: D018971:Insulin-Like Growth Factor Binding Protein 2; D019394:Ki-67 Antigen; D012333:RNA, Messenger; D011980:Receptors, Progesterone; D007335:Insulin-Like Growth Factor II