title: Leisure-time physical activity, body size, and colon cancer in women. Nurses' Health Study Research Group.
abstract: BACKGROUND
  Physical inactivity and high body mass index (weight in kilograms divided by height in square meters) have been linked to increased risk of colon cancer. However, none of the few prospective studies in women has shown a statistically significant reduction in colon cancer incidence or mortality associated with increased leisure-time physical activity.
  
  
  OBJECTIVE
  In this prospective study, we asked whether leisure-time physical activity, body mass index, or body fat distribution could significantly influence the risk of colon cancer in women.
  
  
  METHODS
  The participants in this study were enrolled in the Nurses' Health Study, which began in 1976. Every 2 years, the women provided additional personal information and information on medical risk factors and major medical events. The time spent per week at a variety of leisure-time physical activities was determined, and the time spent at each activity was multiplied by its typical energy expenditure, expressed in terms of metabolic equivalents or METs. The resulting values for each woman were added to yield an MET-hours-per-week score. Reported diagnoses of colon cancer were confirmed by review of hospital records and pathology reports. Relative risks and associated 95% confidence intervals were calculated.
  
  
  RESULTS
  In multivariate analyses that included body mass index, women who expended more than 21 MET-hours per week on leisure-time physical activity had a relative risk of colon cancer of 0.54 (95% confidence interval [CI] = 0.33-0.90) in comparison with women who expended less than 2 MET-hours per week. Women who had a body mass index greater than 29 kg/m2 had a relative risk of colon cancer of 1.45 (95% CI = 1.02-2.07) in comparison with women who had a body mass index less than 21 kg/m2. A tendency toward higher colon cancer risk was observed for increasing waist-to-hip ratio (relative risk = 1.48 [95% CI = 0.88-2.49] for comparison of the highest quintile ratio [>0.833] to the lowest [<0.728]).
  
  
  CONCLUSIONS
  The significant inverse association between leisure-time physical activity and incidence of colon cancer in women in this study is consistent with what has been found in men. Recommendations to increase physical activity and maintain lean body weight should receive greater emphasis as part of a feasible approach to the prevention of colon cancer.
authors.affiliation: Department of Nutrition, Harvard School of Public Health, Boston, MA, USA.
authors.forename: M E
authors.initials: ME
authors.lastname: Martínez
authors.forename: E
authors.initials: E
authors.lastname: Giovannucci
authors.forename: D
authors.initials: D
authors.lastname: Spiegelman
authors.forename: D J
authors.initials: DJ
authors.lastname: Hunter
authors.forename: W C
authors.initials: WC
authors.lastname: Willett
authors.forename: G A
authors.initials: GA
authors.lastname: Colditz
mesh_terms: D000328:Adult; D001824:Body Constitution; D015992:Body Mass Index; D001835:Body Weight; D003110:Colonic Neoplasms / Q000209:etiology*; D015444:Exercise; D005260:Female; D006801:Humans; D007899:Leisure Activities; D008875:Middle Aged; D012306:Risk; D016387:Women's Health