A diabetic case with hemoglobin J-Meerut and low HbA1C levels.
A diabetic patient with hemoglobin (Hb) J-Meerut and low HbA1C levels is reported. An automatic glycohemoglobin analyzer used for the determination of HbA1C revealed an abnormal peak of the peripheral blood obtained from a Japanese female with diabetes. She showed a lower HbA1C level (3.7%) than expected from her fasting plasma glucose (172 mg/dl). High performance liquid chromatography and isoelectric focusing indicated that her abnormal hemoglobin was Hb J-Meerut [alpha 120(H3)Ala-->Glu] and it accounted for 28.3% of the total hemoglobin. Abnormal hemoglobinemia should be considered when a major discrepancy between the levels of HbA1C and fasting plasma glucose is observed.
Yagame
M
M
Department of Internal Medicine, Tokai University School of Medicine, Kanagawa.
Jinde
K
K
Suzuki
D
D
Saotome
N
N
Takano
H
H
Tanabe
R
R
Sato
H
H
Kurokawa
K
K
Sakai
H
H
Matsumae
M
M
Mase
H
H
Harano
T
T
D001786:Blood Glucose / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000235:genetics*; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism*; D006448:Hemoglobin J / Q000235:genetics* / Q000302:isolation & purification / Q000378:metabolism*; D006801:Humans; D007525:Isoelectric Focusing; D008875:Middle Aged
D001786:Blood Glucose; D006442:Glycated Hemoglobin; D006448:Hemoglobin J; C060130:hemoglobin J Meerut