New insights into the control of cell growth; the role of the AxI family.
AxI, Dtk and Mer are recently described receptors that constitute a new receptor tyrosine kinase subfamily. They bind the vitamin K-dependent protein growth-arrest-specific gene 6 (Gas6) that is structurally related to the anticoagulation factor protein S. Studies suggest a role for these receptors in developmental processes. In the function of the hematopoietic and nervous systems and in tumorigenesis.
Crosier
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Department of Molecular Medicine, School of Medicine, University of Auckland, New Zealand.
Crosier
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D000818:Animals; D002455:Cell Division / Q000502:physiology*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins; D015513:Oncogene Proteins / Q000737:chemistry / Q000502:physiology*; D011505:Protein-Tyrosine Kinases / Q000737:chemistry / Q000502:physiology; D011506:Proteins / Q000502:physiology; D011518:Proto-Oncogene Proteins / Q000737:chemistry / Q000502:physiology; D020794:Receptor Protein-Tyrosine Kinases / Q000737:chemistry / Q000502:physiology*; D000076202:c-Mer Tyrosine Kinase; D000094963:Axl Receptor Tyrosine Kinase; D000099255:Growth Arrest-Specific Protein 6
D036341:Intercellular Signaling Peptides and Proteins; D015513:Oncogene Proteins; D011505:Protein-Tyrosine Kinases; D011506:Proteins; D011518:Proto-Oncogene Proteins; D020794:Receptor Protein-Tyrosine Kinases; D000076202:c-Mer Tyrosine Kinase; D000094963:Axl Receptor Tyrosine Kinase; D000099255:Growth Arrest-Specific Protein 6; C097072:MERTK protein, human; C084944:TYRO3 protein, human; C000722289:AXL protein, human