title: Circadian rhythms in mouse suprachiasmatic nucleus explants on multimicroelectrode plates.
abstract: The suprachiasmatic nucleus (SCN) of the mammalian hypothalamus functions as a circadian pacemaker. This study used multimicroelectrode plates to measure extracellular action potential activity simultaneously from multiple sites within the cultured mouse SCN. Neurons within the isolated mouse SCN expressed a circadian rhythm in spontaneous firing rate for weeks in culture.
authors.affiliation: University of Virginia, Department of Biology, Center for Biological Timing, Charlottesville 22903, USA. edh3f@virginia.edu
authors.forename: E D
authors.initials: ED
authors.lastname: Herzog
authors.forename: M E
authors.initials: ME
authors.lastname: Geusz
authors.forename: S B
authors.initials: SB
authors.lastname: Khalsa
authors.forename: M
authors.initials: M
authors.lastname: Straume
authors.forename: G D
authors.initials: GD
authors.lastname: Block
mesh_terms: D000200:Action Potentials; D000818:Animals; D002478:Cells, Cultured; D002940:Circadian Rhythm; D004594:Electrophysiology; D005110:Extracellular Space / Q000502:physiology; D051379:Mice; D008810:Mice, Inbred C57BL; D008839:Microelectrodes; D009474:Neurons / Q000502:physiology; D013493:Suprachiasmatic Nucleus / Q000166:cytology / Q000502:physiology*