[Mode of spreading and biological behavior in bile duct carcinoma].
There are three macroscopic types of hepatic bile duct carcinoma, such as papillary (P-), nodular (N-) and diffuse (D-) type. Immunohistochemical studies demonstrated that P-type expressed cadherin and catenin higher than N- and D-types. The expressions of both cadherin and catenin were found stronger in pap and tub1 than tub2. The nuclear area of cancer cell, correlated with both labeling index of Ki-67 and aberrant accumulation of p53, was significantly larger in the subserosal layer than in the mucosal layer. These may explain the differences in the biological behavior between P- and N, D-types. P-type grows within the mucosal layer, while N- and d-type are more invasive, developing into the subserosal layer. Our clinical data also demonstrates the poor prognosis of N-, D-type of hepatic bile duct carcinoma. On these basis of the biological malignancy of N, D-type, it is critical to remain the surgical margin free from cancer cells to cure this type of hepatic bile duct carcinoma.
Takimoto
A
A
Second Department of Surgery, Yokohama City University, Japan.
Endo
I
I
Ichikawa
Y
Y
Ishikawa
T
T
Togo
S
S
Shimada
H
H
D000230:Adenocarcinoma / Q000473:pathology; D001650:Bile Duct Neoplasms / Q000473:pathology*; D015820:Cadherins / Q000032:analysis; D002291:Carcinoma, Papillary / Q000473:pathology; D006801:Humans; D009361:Neoplasm Invasiveness
D015820:Cadherins