Hereditary non-polyposis colorectal cancer: clinical features and survival. Results from the Danish HNPCC register.
BACKGROUND
Hereditary non-polyposis colorectal cancer (HNPCC) is a dominantly inherited syndrome characterized by the development of colorectal cancer (CRC) and other carcinomas. Our aim was to evaluate tumour parameters and survival in HNPCC.


METHODS
One hundred and eight Danish HNPCC patients were compared with 870 patients with sporadic colorectal cancer.


RESULTS
The median age at CRC diagnosis was 41 years in the HNPCC group. HNPCC patients had significantly more carcinomas located to the right colon (68% against 49% in controls), more synchromous tumours (7% versus 1%), more metachronous CRC after 10 years (29% versus 5%), more localized carcinomas (62% versus 39%), and significantly higher crude cumulative 5-year survival (56% versus 30%).


CONCLUSIONS
CRC in HNPCC behaves differently compared to sporadic cases concerning age of onset, frequency of multiple lesions, and location. The metastatic tendency is less than in sporadic CRC and the survival is better.
Myrhøj
T
T
Dept. of Surgical Gastroenterology, Hvidovre Hospital, Denmark.
Bisgaard
M L
ML
Bernstein
I
I
Svendsen
L B
LB
Søndergaard
J O
JO
Bülow
S
S
D000328:Adult; D017668:Age of Onset; D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000175:diagnosis / Q000401:mortality; D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000175:diagnosis* / Q000401:mortality*; D003718:Denmark / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D011379:Prognosis; D012042:Registries; D012189:Retrospective Studies; D015996:Survival Rate