In vivo and in vitro cellular response to Schistosoma japonicum eggs in hosts with differing susceptibilities.
A comparative study of the cellular response to Schistosoma japonicum eggs was conducted in order to explore its significance, using hosts with differing susceptibilities to the parasite. In experimentally induced, synchronized hepatic granuloma formation, animal species formed each characteristic feature of the granulomas, and the magnitude of tissue reaction was significantly larger in highly susceptible hosts, such as mice and hamsters, while less susceptible hosts, such as rats and quails, formed smaller granulomas. Confluent neutrophils were seen within the tissue lesions for mice and hamsters, while rats and quails showed obviously scanty neutrophils. Guinea pigs failed to develop any granulomas. When splenic cells and bone marrow cells were used for in vitro granuloma formation, bone marrow cells showed markedly higher reactions than splenic cells from naive or sensitized animals and the reactivities of bone marrow cells from susceptible hosts, mice and hamsters, were clearly higher than those from rats, indicating similar results to those of in vivo granuloma formation. This study indicates that the in vivo and in vitro cellular response to S. japonicum eggs varies greatly according to the host's susceptibility, independent of whether the host is a naive or sensitized animal. Our results seem to support the concept that the parasites exploit the host immune system in order to complete their life-span.
Hirata
M
M
Department of Parasitology, Kurume University School of Medicine, Japan.
Kage
M
M
Habe
S
S
Agatsuma
T
T
Fukuma
T
T
D000818:Animals; D006224:Cricetinae; D005260:Female; D006099:Granuloma / Q000276:immunology / Q000469:parasitology / Q000473:pathology; D006168:Guinea Pigs; D006790:Host-Parasite Interactions / Q000276:immunology; D007114:Immunization; D066298:In Vitro Techniques; D008107:Liver Diseases / Q000276:immunology / Q000469:parasitology / Q000473:pathology; D051379:Mice; D008808:Mice, Inbred CBA; D010063:Ovum / Q000276:immunology; D011784:Quail; D051381:Rats; D017208:Rats, Wistar; D012549:Schistosoma japonicum / Q000276:immunology* / Q000472:pathogenicity*; D012554:Schistosomiasis japonica / Q000276:immunology* / Q000469:parasitology / Q000473:pathology*; D013045:Species Specificity; D013997:Time Factors