Increased striatal glutamate transporter by repeated intermittent administration of methamphetamine.
We have examined the immunoreactivities of a glutamate (Glu) transporter, GLT-1, in rat brains treated with a single or repeated intermittent administration of methamphetamine (MAP). In the stratum of behaviorally sensitized rate induced by repeated intermittent MAP treatment, GLT-1 immunoreactivities were increased by 51%. There was no difference in the GLT-1 immunoreactivities in all regions examined between rate treated with a single administration of MAP and the control rats. These results suggest that hyperglutamatergic activity in the striatum is involved in the induction of behavioral sensitization caused by MAP.
Shirai
Y
Y
Department of Psychiatry and Neurology, Kobe University School of Medicine, Japan.
Shirakawa
O
O
Nishino
N
N
Saito
N
N
Nakai
H
H
D018528:ATP-Binding Cassette Transporters / Q000032:analysis*; D027322:Amino Acid Transport System X-AG; D000818:Animals; D003342:Corpus Striatum / Q000737:chemistry* / Q000187:drug effects*; D018698:Glutamic Acid / Q000032:analysis / Q000378:metabolism*; D008297:Male; D008694:Methamphetamine / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley
D018528:ATP-Binding Cassette Transporters; D027322:Amino Acid Transport System X-AG; D018698:Glutamic Acid; D008694:Methamphetamine