title: Cryofibrinogenemia with polyarthralgia, Raynaud's phenomenon and acral ulcer in a patient with Graves' disease treated with methimazole.
abstract: Cryofibrinogenemia is a cryopathy in which hypersensitivity to cold is a prominent feature. Cryofibrinogenemia developed in an 18-year-old Japanese female patient during methimazole therapy for Graves' disease. She developed cryopathy (livedo reticularis, Raynaud's phenomenon and acral ulcer) and polyarthralgia during methimazole therapy, and we detected cryofibrinogen in her plasma. Her symptoms resolved after administration of prostaglandins and anticoagulants. Several reports indicate that methimazole therapy induces autoantibody-related disease. In the present case, we cannot exclude the possibility that methimazole therapy contributed to the cryofibrinogenemia.
authors.affiliation: First Department of Internal Medicine, Osaka Medical College.
authors.forename: K
authors.initials: K
authors.lastname: Hosoi
authors.forename: S
authors.initials: S
authors.lastname: Makino
authors.forename: Y
authors.initials: Y
authors.lastname: Yamano
authors.forename: M
authors.initials: M
authors.lastname: Sasaki
authors.forename: T
authors.initials: T
authors.lastname: Takeuchi
authors.forename: S
authors.initials: S
authors.lastname: Sakane
authors.forename: N
authors.initials: N
authors.lastname: Ohsawa
mesh_terms: D000293:Adolescent; D000925:Anticoagulants / Q000627:therapeutic use; D013956:Antithyroid Agents / Q000009:adverse effects*; D018771:Arthralgia / Q000150:complications* / Q000188:drug therapy; D003450:Cryoglobulins / Q000378:metabolism*; D005260:Female; D015241:Fibrinogens, Abnormal / Q000378:metabolism*; D016523:Foot Ulcer / Q000150:complications* / Q000188:drug therapy; D006111:Graves Disease / Q000150:complications* / Q000188:drug therapy*; D006801:Humans; D008713:Methimazole / Q000009:adverse effects*; D011465:Prostaglandins, Synthetic / Q000627:therapeutic use; D011928:Raynaud Disease / Q000150:complications* / Q000188:drug therapy; D017445:Skin Diseases, Vascular / Q000150:complications
chemical_list: D000925:Anticoagulants; D013956:Antithyroid Agents; D003450:Cryoglobulins; D015241:Fibrinogens, Abnormal; D011465:Prostaglandins, Synthetic; C041874:cryofibrinogen; D008713:Methimazole