title: The combined value of chemoprophylaxis and pneumococcal vaccine in the prevention of recurrent pneumococcal meningitis.
abstract: We report the case of an immunocompetent patient who has been the subject of 39 episodes of recurrent pneumococcal meningitis over a 20 year period. The recurrences of bacterial meningitis due to cerebrospinal fluid leakage and the presence of chronic sinusitis were not influenced by the surgical repair of a fistula and the repeated surgical draining interventions on suppurating chronic sinusital foci. Phenoxymethylpenicillin treatment reduced the number of recurrences and the combination of pneumococcal vaccine and penicillin prophylaxis allowed a 5 year period free of any recurrences.
authors.affiliation: University Clinic of Infectious Diseases, N Gh Lupu Hospital, Bucharest, Romania.
authors.forename: A
authors.initials: A
authors.lastname: Hristea
authors.forename: M
authors.initials: M
authors.lastname: Chiotan
authors.forename: M
authors.initials: M
authors.lastname: Tudose
authors.forename: F
authors.initials: F
authors.lastname: Mihalcu
mesh_terms: D000293:Adolescent; D001428:Bacterial Vaccines / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008586:Meningitis, Pneumococcal / Q000517:prevention & control*; D010404:Penicillin V / Q000627:therapeutic use*; D010406:Penicillins / Q000627:therapeutic use*; D012008:Recurrence; D013296:Streptococcus pneumoniae / Q000276:immunology*
chemical_list: D001428:Bacterial Vaccines; D010406:Penicillins; D010404:Penicillin V