title: [Hypercapnia induced reversible opening of the blood-brain barrier in experimental hyperbilirubinemia].
abstract: OBJECTIVE
  The incidence of bilirubin encephalopathy in extremely ill neonates with low serum bilirubin is stimulating interest in factors that can modify the blood-brain barrier permeability and allow the passage of bilirubin-albumin macrocomplexes, which may be produced by hypercapnia.
  
  
  METHODS
  Without modifying the normal bilirubin-albumin affinity, we increased cerebral flow by two levels of hypercapnia (PCO2 67.1 and 101.9 mmHg), acquired by inhalation of CO2 enriched air (5 and 15%) and a decrease in pH (7.00 and 6.93).
  
  
  RESULTS
  We demonstrate an increment in cerebral bilirubin deposition (control 2.43 +/- 0.54 mg/g versus 3.29 +/- 0.43 and 3.28 +/- 1.07, F = 4.80, p < 0.05) and I125 albumin (control 26.1 +/- 95.8 micrograms/g versus 364.4 +/- 156.1 and 430.8 +/- 122.4, F03.34, p < 0.05).
authors.affiliation: Departamento de Pediatría, Hospital Materno-Infantil, Las Palmas.
authors.forename: F
authors.initials: F
authors.lastname: Domínguez Ortega
authors.forename: G
authors.initials: G
authors.lastname: González Azpeitia
authors.forename: M
authors.initials: M
authors.lastname: Cidrás Pidre
authors.forename: J
authors.initials: J
authors.lastname: Calvo Rosales
mesh_terms: D000142:Acidosis, Respiratory; D000818:Animals; D001812:Blood-Brain Barrier; D006932:Hyperbilirubinemia / Q000097:blood*; D006935:Hypercapnia / Q000175:diagnosis*; D007565:Jaundice; D007647:Kernicterus; D051381:Rats; D017207:Rats, Sprague-Dawley; D013053:Spectrophotometry