title: Skin tolerance of adapalene 0.1% gel in combination with other topical antiacne treatments.
abstract: BACKGROUND
  Adapalene (Differin gel) is a new naphthoic acid derivative developed for the topical treatment of acne vulgaris.
  
  
  OBJECTIVE
  We assessed, in healthy volunteers, the skin irritancy potential of three combinations, each including adapalene 0.1% gel and one topical marketed antiacne product.
  
  
  METHODS
  Twenty-five healthy volunteers were enrolled in a 21-day cumulative irritancy study performed in a double-blind, randomized, controlled, intraindividual design. Five days a week, the three materials (benzoyl peroxide, clindamycin phosphate, and erythromycin) were applied in a nonocclusive manner either alone or in combination with adapalene gel on seven cutaneous sites on the upper back. Adapalene was applied in the evening whereas the three other materials were applied in the morning. Irritation was evaluated and scored daily except on weekends.
  
  
  RESULTS
  All materials were well-tolerated when tested alone. The combinations of adapalene 0.1% gel and either benzoyl peroxide, clindamycin phosphate, or erythromycin were also well-tolerated. The mean cumulative irritancy indices indicated that all three combinations were nonirritating.
  
  
  CONCLUSIONS
  Under the conditions of the study, all tested treatments alone or in combination appeared nonirritating.
authors.affiliation: CIRD Galderma, Sophia Antipolis, France.
authors.forename: D
authors.initials: D
authors.lastname: Caron
authors.forename: V
authors.initials: V
authors.lastname: Sorba
authors.forename: A
authors.initials: A
authors.lastname: Clucas
authors.forename: M
authors.initials: M
authors.lastname: Verschoore
mesh_terms: D000068816:Adapalene; D000287:Administration, Topical; D000328:Adult; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D001585:Benzoyl Peroxide / Q000494:pharmacology; D002981:Clindamycin / Q000031:analogs & derivatives / Q000494:pharmacology; D004311:Double-Blind Method; D004917:Erythromycin / Q000494:pharmacology; D005260:Female; D005782:Gels; D006801:Humans; D007641:Keratolytic Agents / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D009281:Naphthalenes / Q000008:administration & dosage*; D012867:Skin / Q000187:drug effects*
chemical_list: D000900:Anti-Bacterial Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D005782:Gels; D007641:Keratolytic Agents; D009281:Naphthalenes; D000068816:Adapalene; D002981:Clindamycin; D004917:Erythromycin; C007084:clindamycin phosphate; D001585:Benzoyl Peroxide