title: Isolation and characterization of an acetylated impurity in Escherichia coli-derived recombinant human interleukin-10 (IL-10) drug substance.
authors.affiliation: Schering-Plough Research Institute, Kenilworth, New Jersey 07033, USA.
authors.forename: M N
authors.initials: MN
authors.lastname: Pflumm
authors.forename: S C
authors.initials: SC
authors.lastname: Gruber
authors.forename: A
authors.initials: A
authors.lastname: Tsarbopoulos
authors.forename: D
authors.initials: D
authors.lastname: Wylie
authors.forename: B
authors.initials: B
authors.lastname: Pramanik
authors.forename: J N
authors.initials: JN
authors.lastname: Bausch
authors.forename: S T
authors.initials: ST
authors.lastname: Patel
mesh_terms: D002851:Chromatography, High Pressure Liquid; D004340:Drug Contamination; D004926:Escherichia coli / Q000737:chemistry*; D006801:Humans; D016753:Interleukin-10 / Q000737:chemistry*; D008239:Lysine / Q000031:analogs & derivatives* / Q000302:isolation & purification; D013058:Mass Spectrometry; D011994:Recombinant Proteins / Q000737:chemistry
chemical_list: D011994:Recombinant Proteins; D016753:Interleukin-10; C016949:N-epsilon-acetyllysine; D008239:Lysine