title: Five day and ten day triple therapy (amoxicillin, furazolidone and metronidazole) in the treatment of duodenal ulcer.
abstract: This investigation aimed to compare bacterial eradication and healing in patients with active duodenal ulcer treated with a combination of furazolidone 600 mg/day and metronidazole 750 mg/day and amoxicillin 1.5 and g/day for 5 (TT5) or 10 (TT10) days. Fifty four (TT5 = 28 and TT10 = 26) patients were included in the study. Ulcer healing was observed in 77.8% of TT5 Group and in 75% of TT10 Group at week 4. H pylori eradication was observed in 51.9% and 65% respectively (p > 0.05). When all patients were grouped, a significantly healing rate was observed in those eradicated as compared to those not eradicated (p = 0.03). We concluded that extending the treatment to 10 days did not significantly influence the results of ulcer healing and eradication of Helicobacter pylori.
authors.affiliation: Department of Gastroenterology, University of São Paulo Medical School.
authors.forename: S
authors.initials: S
authors.lastname: Zaterka
authors.forename: J N
authors.initials: JN
authors.lastname: Eisig
authors.forename: D
authors.initials: D
authors.lastname: Chinzon
authors.forename: H K
authors.initials: HK
authors.lastname: Boyd
authors.forename: A
authors.initials: A
authors.lastname: Bastos
authors.forename: T
authors.initials: T
authors.lastname: Dias
authors.forename: A A
authors.initials: AA
authors.lastname: Laudanna
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000658:Amoxicillin / Q000008:administration & dosage*; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage*; D002648:Child; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D004381:Duodenal Ulcer / Q000188:drug therapy*; D005260:Female; D005664:Furazolidone / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D008795:Metronidazole / Q000008:administration & dosage*; D008875:Middle Aged; D010406:Penicillins / Q000008:administration & dosage*; D012189:Retrospective Studies
chemical_list: D000891:Anti-Infective Agents, Local; D010406:Penicillins; D008795:Metronidazole; D005664:Furazolidone; D000658:Amoxicillin