[Formation of sister chromatid exchanges and reparative DNA synthesis in workers exposed to nickel compounds].
In workers from a nickel processing plant, residents of the surrounding industrial zone, and a control group, levels of sister chromatid exchanges (SCE, 33 individuals) and DNA repair synthesis (DRS, 79 individuals) were estimated. Individual variations in SCE level did not correlate to the duration of exposure to nickel compounds or the level of pollution. A statistically significant increase of SCE level among smokers compared to nonsmokers was revealed. Workers exposed to nickel compounds were demonstrated to have a statistically significant increase in the inhibition of DNA repair synthesis.
Perminova
I N
IN
Alekhina
N I
NI
Sinel'shchikova
T A
TA
Osipova
T B
TB
Zasukhina
G D
GD
D000328:Adult; D017677:Age Distribution; D016022:Case-Control Studies; D004260:DNA Repair; D004785:Environmental Pollutants; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects*; D008875:Middle Aged; D009532:Nickel / Q000009:adverse effects*; D016273:Occupational Exposure; D012307:Risk Factors; D012854:Sister Chromatid Exchange / Q000187:drug effects*; D012907:Smoking / Q000009:adverse effects
D004785:Environmental Pollutants; D009532:Nickel