title: Evaluation of UICC TNM classification for pancreatic cancer. A study of 228 patients.
abstract: CONCLUSIONS
  A different stage grouping of TNM factors can improve the predictivity of the UICC TNM classification for pancreatic cancer. Nevertheless, the Japanese Pancreas Society (JPS) classification maintains a higher prognostic value.
  
  
  BACKGROUND
  The use of a reliable staging classification facilitates the evaluation of anticancer treatments and the correct management of patients. The aim of the present study was to evaluate the prognostic value of three modified UICC TNM classifications, obtained by different stage grouping of the UICC TNM factors, comparing their predictivity to the standard UICC and the JPS classifications.
  
  
  METHODS
  Clinical material consisted of 228 patients who underwent resection for pancreatic cancer. The reliability of the classifications was analyzed by the following methods: univariate analysis of stage survival curves; multivariate analysis of each classification after adjusting for grading and radicality; and correlation between the patients' distribution in the stages of each classification and in survival classes.
  
  
  RESULTS
  The following modified UICC classification allowed a better differentiation of stage II and III survival (P = 0.08) than standard UICC (P = 0.74): stage I: T1N0M0; stage II: T1N1M0/T2N0M0: stage III: T2N1M0/T3 any NM0; stage IV: M1. The JPS classification better discriminated between the different stages (P < 0.001). All classifications had an independent prognostic value by multivariate analysis. The correlation between stages and survival classes was higher for the JPS classification than either UICC TNM classification or the modified UICC classifications.
authors.affiliation: Department of Surgery, Borgoroma Hospital, Verona, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Balzano
authors.forename: C
authors.initials: C
authors.lastname: Bassi
authors.forename: A
authors.initials: A
authors.lastname: Zerbi
authors.forename: M
authors.initials: M
authors.lastname: Falconi
authors.forename: G
authors.initials: G
authors.lastname: Calori
authors.forename: G
authors.initials: G
authors.lastname: Butturini
authors.forename: B E
authors.initials: BE
authors.lastname: Leone
authors.forename: P
authors.initials: P
authors.lastname: Pederzoli
authors.forename: V
authors.initials: V
authors.lastname: Di Carlo
mesh_terms: D000230:Adenocarcinoma / Q000145:classification / Q000401:mortality / Q000473:pathology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009367:Neoplasm Staging / Q000379:methods*; D010190:Pancreatic Neoplasms / Q000145:classification* / Q000401:mortality / Q000473:pathology*; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate