Anti-galectin-1 autoantibodies in serum of patients with neurological diseases.
The presence of autoantibodies to human brain galectin-1 was investigated in serum from patients with multiple sclerosis, patients with or without evidence of other neurological disorders, and healthy controls, using an ELISA on purified brain galectin-1. Levels of autoantibodies to galectin-1 were significantly higher in patients than in healthy controls. Comparison of levels of anti-galectin-1 and anti-idiotypic antibodies mimicking human brain galectin-1 (L-IgG) showed that the highest levels of autoantibodies were present in patients with low levels of L-IgG. This finding can be explained by hypothesizing that the concentration of autoantibodies to galectin-1 is possibly associated with impairment of the regulation of the immune system.
Lutomski
D
D
Laboratoire de Biochimie et Technologie des Protéines, UFR SMBH-Léonard de Vinci, Bobigny, France.
Joubert-Caron
R
R
Lefebure
C
C
Salama
J
J
Belin
C
C
Bladier
D
D
Caron
M
M
D000328:Adult; D000888:Antibodies, Anti-Idiotypic / Q000097:blood; D000915:Antibody Affinity; D001323:Autoantibodies / Q000097:blood*; D001921:Brain / Q000276:immunology; D005260:Female; D005697:Galactosides / Q000276:immunology / Q000378:metabolism; D037483:Galectin 1; D006388:Hemagglutinins / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood / Q000378:metabolism; D009103:Multiple Sclerosis / Q000097:blood / Q000276:immunology; D009422:Nervous System Diseases / Q000097:blood* / Q000276:immunology*
D000888:Antibodies, Anti-Idiotypic; D001323:Autoantibodies; D005697:Galactosides; D037483:Galectin 1; D006388:Hemagglutinins; D007074:Immunoglobulin G; C007816:beta-galactoside