[Clenbuterol poisoning. Clinical and analytical data on an outbreak in Móstoles, Madrid].
OBJECTIVE
To report the clinical manifestations and analytical findings in an epidemic outbreak of acute food poisoning with clenbuterol.


METHODS
The clinical manifestations, physical examination findings and results of complementary tests are reported of fifteen patients performed by veal liver contaminated with clenbuterol. The clinical course of patients at 72 hours is reported. A quantitative measurement of clenbuterol in urine specimens from patients and in a veal liver specimen was performed by high pressure liquid chromatography (HPLC).


RESULTS
The male/female distribution of patients was 7/8 respectively, with age ranging from 6 to 44 years. Symptoms appeared after 30 minutes to 2 hours of having ingested veal liver in 93% of cases. Patients presented at the Emergency Department with tremors, palpitations, anxiety, malaise, nausea, and pruritus as the most common complaints. On physical examination tachycardia was noted in 100% of cases. The analytical data included mild hypokaliemia (66%) and leukocytosis (28%). Only one patient required hospital admission on account of an hypertensive crisis. After 72 hours, 67% of patients were asymptomatic. The remaining patients had mild symptoms which included headache, myalgia, asthenia and anorexia. Serum potassium values returned to normality (p < 0.05). Urine measurements of clenbuterol were positive for all analyzed cases (50 +/- 42 ng/ml). The concentration of clenbuterol in a veal liver sample was 500 ppb.


CONCLUSIONS
Clenbuterol poisoning should be suspected when symptoms of adrenergic hyperstimulation occur after the ingestion of meal, usually liver. Common symptoms include tachycardia and mild hypopotasemia. Diagnosis is confirmed by quantitative measurement of clenbuterol in urine. Most patients improve spontaneously shortly afterwards.
Bilbao Garay
J
J
Servicio de Medicina Interna, Hospital de Móstoles, Madrid.
Hoyo Jiménez
J F
JF
López Jiménez
M
M
Vinuesa Sebastián
M
M
Perianes Matesanz
J
J
Muñoz Moreno
P
P
Ruiz Galiana
J
J
D000293:Adolescent; D000318:Adrenergic beta-Agonists / Q000506:poisoning*; D000328:Adult; D002648:Child; D002976:Clenbuterol / Q000506:poisoning*; D004196:Disease Outbreaks; D005260:Female; D005506:Food Contamination; D006801:Humans; D008297:Male; D008460:Meat; D011041:Poisoning / Q000175:diagnosis / Q000453:epidemiology; D013030:Spain
D000318:Adrenergic beta-Agonists; D002976:Clenbuterol