Glutamine and regulation of gene expression in mammalian cells. Special reference to phosphoenolpyruvate carboxykinase (PEPCK).
The repertoire of the actions of specific amino acids on gene expression is relatively limited in mammalian cells. Glutamine constitutes the most studied amino acid and recent works intended to demonstrate its mechanism of action on two genes: the beta-actin and the phosphoenolpyruvate carboxykinase genes. From these studies, it appears that glutamine may regulate gene expression by, at least, two different mechanisms: one through the glutamine-induced cell swelling, and another through its intracellular metabolism. The involvement of phosphatidylinositol 3-kinase in the signaling pathway triggered by cell swelling is discussed.
Quillard
M
M
Groupe de Biochimie et Physiopathologie Digestive et Nutritionnelle (GBPDN), Institut Fédératif de Recherches Multidisciplinaires sur les Peptides n. 23 (IFRMP), UFR Médecine-Pharmacie de Rouen, Saint-Etienne-du-Rouvray, France.
Renouf
S
S
Husson
A
A
Meisse
D
D
Lavoinne
A
A
D000199:Actins / Q000235:genetics; D000730:Androstadienes / Q000494:pharmacology; D000818:Animals; D016466:CHO Cells; D048429:Cell Size; D006224:Cricetinae; D015971:Gene Expression Regulation, Enzymologic; D005973:Glutamine / Q000502:physiology*; D006801:Humans; D008099:Liver / Q000166:cytology / Q000201:enzymology; D019869:Phosphatidylinositol 3-Kinases; D010729:Phosphoenolpyruvate Carboxykinase (GTP) / Q000235:genetics*; D017853:Phosphotransferases (Alcohol Group Acceptor) / Q000502:physiology; D011090:Polyenes / Q000494:pharmacology; D051381:Rats; D020123:Sirolimus; D014882:Water-Electrolyte Balance; D000077191:Wortmannin
D000199:Actins; D000730:Androstadienes; D011090:Polyenes; D005973:Glutamine; D019869:Phosphatidylinositol 3-Kinases; D017853:Phosphotransferases (Alcohol Group Acceptor); D010729:Phosphoenolpyruvate Carboxykinase (GTP); D020123:Sirolimus; D000077191:Wortmannin