Chromosomal localization of three human dual specificity phosphatase genes (DUSP4, DUSP6, and DUSP7).
Mitogen-activated protein (MAP) kinase phosphatases constitute a growing family of dual specificity phosphatases thought to play a role in the dephosphorylation and inactivation of MAP kinases and are therefore likely to be important in the regulation of diverse cellular processes such as proliferation, differentiation, and apoptosis. For this reason it has been suggested that MAP kinase phosphatases may be tumor suppressors. We have determined the chromosomal locations of three human dual specificity phosphatase genes by fluorescence in situ hybridization and radiation hybrid mapping. The genes were localized to three different chromosomes, MKP2 (DUSP4) to 8p11-p12, MKP3 (DUSP6) to 12q22-q23, and MKPX (DUSP7) to 3p21. This will allow the potential roles of these genes in disease processes to be evaluated.
Smith
A
A
Cancer Research Campaign Centre for Cell and Molecular Biology, Chester Beatty Laboratories, The Institute of Cancer Research, London, United Kingdom.
Price
C
C
Cullen
M
M
Muda
M
M
King
A
A
Ozanne
B
B
Arkinstall
S
S
Ashworth
A
A
D001483:Base Sequence; D002874:Chromosome Mapping; D002881:Chromosomes, Human, Pair 12; D002893:Chromosomes, Human, Pair 3; D002898:Chromosomes, Human, Pair 8; D018076:DNA, Complementary; D054642:Dual Specificity Phosphatase 6; D054637:Dual-Specificity Phosphatases; D006801:Humans; D054639:Mitogen-Activated Protein Kinase Phosphatases; D008969:Molecular Sequence Data; D010749:Phosphoprotein Phosphatases; D017027:Protein Tyrosine Phosphatases / Q000235:genetics*
D018076:DNA, Complementary; D054639:Mitogen-Activated Protein Kinase Phosphatases; D010749:Phosphoprotein Phosphatases; C490583:DUSP4 protein, human; C517035:DUSP6 protein, human; C107523:DUSP7 protein, human; D054642:Dual Specificity Phosphatase 6; D054637:Dual-Specificity Phosphatases; D017027:Protein Tyrosine Phosphatases