[The tubulointerstitial changes in different clinical and morphological types of chronic glomerulonephritis].
As shown by the data available on 228 patients with chronic glomerulonephritis, tubulointerstitial alterations (TIA) occur primarily in mesangiocapillary glomerulonephritis, focal-segmental glomerular hyalinosis/sclerosis, diffuse fibroplastic glomerulonephritis as well as in active nephritic and nephrotic-hypertensive types. In 186 patients with chronic glomerulonephritis chronic renal insufficiency evidencing enhanced progression (EP) if arose within 7 years since the disease onset in the presence of TIA was registered significantly more frequently. TIA patients demonstrated EP as a rule in prognostically unfavorable active nephritic and nephrotic-hypertensive types. The relationship between TIA and EP may be explained by their association with unfavourable clinical types suggesting poor prognosis.
Ratner
M Ia
MIa
Fedorova
N D
ND
Makurov
A I
AI
D000293:Adolescent; D000328:Adult; D016009:Chi-Square Distribution; D002908:Chronic Disease; D018450:Disease Progression; D005260:Female; D005921:Glomerulonephritis / Q000145:classification / Q000473:pathology*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000473:pathology; D007684:Kidney Tubules / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011379:Prognosis