title: Genes that guide growth cones along the C. elegans ventral nerve cord.
abstract: During nervous system development, growth cone pioneering and fasciculation contribute to nerve bundle structure. Pioneer growth cones initially navigate along neuroglia to establish an axon scaffold that guides later extending growth cones. In C. elegans, the growth cone of the PVPR neuron pioneers the left ventral nerve cord bundle, providing a path for the embryonic extensions of the PVQL and AVKR growth cones. Later during larval development, the HSNL growth cone follows cues in the left ventral nerve cord bundle provided by the PVPR and PVQL axons. Here we show that mutations in the genes enu-1, fax-1, unc-3, unc-30, unc-42 and unc-115 disrupt pathfinding of growth cones along the left ventral nerve cord bundle. Our results indicate that unc-3 and unc-30 function in ventral nerve cord pioneering and that enu-1, fax-1, unc-42 and unc-115 function in recognition of the PVPR and PVQL axons by the AVKR and HSNL growth cones.
authors.affiliation: Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA.
authors.forename: B
authors.initials: B
authors.lastname: Wightman
authors.forename: R
authors.initials: R
authors.lastname: Baran
authors.forename: G
authors.initials: G
authors.lastname: Garriga
mesh_terms: D000818:Animals; D001369:Axons / Q000502:physiology* / Q000648:ultrastructure; D017173:Caenorhabditis elegans / Q000033:anatomy & histology / Q000196:embryology* / Q000235:genetics*; D002450:Cell Communication; D002465:Cell Movement; D019084:Fluorescent Antibody Technique, Indirect; D017238:Genes, Helminth; D017930:Genes, Reporter; D049452:Green Fluorescent Proteins; D007814:Larva; D008164:Luminescent Proteins / Q000096:biosynthesis / Q000235:genetics; D009154:Mutation; D009420:Nervous System / Q000033:anatomy & histology / Q000196:embryology*
chemical_list: D008164:Luminescent Proteins; D049452:Green Fluorescent Proteins