Recent solution structures of RNA and its complexes with drugs, peptides and proteins.
The past two years have seen remarkable progress in the study of RNA structure: the predicted era of RNA structural biology has arrived. Crystallographic structures of the hammerhead ribozyme and of a large subunit of a group I self-splicing intron have begun to reveal the structural basis of RNA enzymatic activity. A remarkable number of structures of small RNAs and of complexes with drugs, peptides and one protein domain have been determined by NMR.
Ramos
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A
MRC Laboratory of Molecular Biology, Cambridge, UK.
Gubser
C C
CC
Varani
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G
D005544:Forecasting; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D010455:Peptides / Q000378:metabolism; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D011506:Proteins / Q000378:metabolism*; D012313:RNA / Q000737:chemistry* / Q000378:metabolism*
D010455:Peptides; D004364:Pharmaceutical Preparations; D011506:Proteins; D012313:RNA