Molecular typing of HLA class I and class II antigens in Indian kala-azar patients.
HLA has been shown to be associated with many diseases. To find out whether host genetic factors like the HLA are involved in susceptibility to kala-azar (visceral leishmaniasis) in India, we formulated an association study with genetically related controls. All samples were typed by PCR SSOP (sequence specific oligonucleotide probes) for HLA class I (A and B) and class II (DR) antigens. The test of association we used was the transmission disequilibrium test (TDT). No significant evidence for association with any of the three HLA loci was obtained.
Singh
N
N
Department of Biochemistry, Central Drug Research Institute, Lucknow, India.
Sundar
S
S
Williams
F
F
Curran
M D
MD
Rastogi
A
A
Agrawal
S
S
Middleton
D
D
D004198:Disease Susceptibility; D015395:Histocompatibility Antigens Class I / Q000235:genetics* / Q000276:immunology; D000949:Histocompatibility Antigens Class II / Q000235:genetics* / Q000276:immunology; D006790:Host-Parasite Interactions / Q000235:genetics* / Q000276:immunology; D006801:Humans; D007194:India; D007898:Leishmaniasis, Visceral / Q000235:genetics* / Q000276:immunology; D010375:Pedigree; D016133:Polymerase Chain Reaction / Q000379:methods
D015395:Histocompatibility Antigens Class I; D000949:Histocompatibility Antigens Class II