title: SV-IV, a major protein secreted from rat seminal vesicle epithelium, promotes lymphocyte cytotoxic activity against the lymphoblastoid Raji cell line in human peripheral blood mononuclear cells.
abstract: The treatment of human peripheral blood mononuclear cells (PBMC) with micromolar concentrations of SV-IV, a major protein secreted from the rat seminal vesicle epithelium, promotes in this cell population a marked cytotoxic activity against the Raji lymphoblastoid cell line. This activity is apparently due to cell-to-cell contact interactions. The expression of HLA DR on Raji cells has a modulatory effect on the SV-IV-induced cytotoxic activity. The experimental evidence strongly suggests that the cytotoxic effector cells are functionally activated NK cells.
authors.affiliation: CNR Institute of Protein Biochemistry and Enzymology, Naples, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Peluso
authors.forename: M
authors.initials: M
authors.lastname: Marchese
authors.forename: A
authors.initials: A
authors.lastname: Furgi
authors.forename: M
authors.initials: M
authors.lastname: Ranieri
authors.forename: S
authors.initials: S
authors.lastname: Russo Spena
authors.forename: G
authors.initials: G
authors.lastname: Ravagnan
authors.forename: M P
authors.initials: MP
authors.lastname: Fuggetta
authors.forename: R
authors.initials: R
authors.lastname: Porta
authors.forename: V
authors.initials: V
authors.lastname: Metafora
authors.forename: S
authors.initials: S
authors.lastname: Metafora
mesh_terms: D000818:Animals; D003602:Cytotoxicity, Immunologic; D004848:Epithelium / Q000378:metabolism; D006801:Humans; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D011506:Proteins / Q000276:immunology* / Q000378:metabolism; D051381:Rats; D029607:Seminal Vesicle Secretory Proteins; D012669:Seminal Vesicles / Q000378:metabolism*; D014407:Tumor Cells, Cultured
chemical_list: D011506:Proteins; D029607:Seminal Vesicle Secretory Proteins; C101178:Svs4 protein, rat