Effects of an HMG-CoA reductase inhibitor, pravastatin, and bile sequestering resin, cholestyramine, on plasma plant sterol levels in hypercholesterolemic subjects.
To study exogenous sterol metabolism during the suppression or stimulation of cholesterol biosynthesis induced by treatments for hyperlipidemia, we determined plasma plant sterol concentrations before and after administration of an HMG-CoA reductase inhibitor, pravastatin, and compared these with changes in these plasma sterol levels by the bile-sequestrating resin, cholestyramine. The effects of the drugs were also studied in a sitosterolemic patient who has had increased plasma levels of plant sterols. Plasma cholesterol levels determined by the HPLC method were decreased significantly after administration of pravastatin. Plasma plant sterol (sitosterol and campesterol) as well as cholestanol concentrations were also significantly reduced. Cholestyramine administration decreased plasma levels of cholesterol, but did not change those of plant sterols in the hypercholesterolemic subjects. Pravastatin had little effect in a sitosterolemic patient on plasma levels of sterols, where cholestyramine decreased the plasma levels of both cholesterol and cholestanol. These results indicate that treatment with the HMG-CoA reductase inhibitor decreases plasma plant sterol concentrations, and suggest that the increased plasma plant sterol levels in sitosterolemia might not be due to the decreased cholesterol biosynthesis in vivo.
Hidaka
H
H
Third Department of Medicine, Shiga University of Medical Science, Japan.
Kojima
H
H
Kawabata
T
T
Nakamura
T
T
Konaka
K
K
Kashiwagi
A
A
Kikkawa
R
R
Shigeta
Y
Y
D000214:Acyl Coenzyme A / Q000037:antagonists & inhibitors; D000328:Adult; D000924:Anticholesteremic Agents / Q000008:administration & dosage*; D002792:Cholestyramine Resin / Q000008:administration & dosage*; D002851:Chromatography, High Pressure Liquid; D004791:Enzyme Inhibitors / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood* / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D010840:Phytosterols / Q000097:blood*; D017035:Pravastatin / Q000008:administration & dosage*
D000214:Acyl Coenzyme A; D000924:Anticholesteremic Agents; D004791:Enzyme Inhibitors; D010840:Phytosterols; D002792:Cholestyramine Resin; C008047:3-hydroxy-3-methylglutaryl-coenzyme A; D017035:Pravastatin