Effect of granulocyte colony-stimulating factor on granulopoiesis of congenital neutropenic children.
We report on two patients with congenital neutropenia, who were treated with filgrastim (recombinant human granulocyte-colony stimulating factor, G-CSF). A poor growth of bone marrow colonies and low sensitivity of colony forming units to colony stimulating factor in vitro before treatment seemed to be associated with a requirement for higher doses of G-CSF to achieve good clinical response in vivo.
Benkö
I
I
Department of Pharmacology, University Medical School of Debrecen, Hungary.
Maródi
L
L
Megyeri
A
A
Káposzta
R
R
Kovács
P
P
D001773:Blood Cells / Q000473:pathology; D001853:Bone Marrow / Q000187:drug effects / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D003114:Colony-Forming Units Assay; D005260:Female; D000069585:Filgrastim; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000627:therapeutic use*; D006098:Granulocytes / Q000187:drug effects* / Q000473:pathology / Q000502:physiology; D006410:Hematopoiesis / Q000187:drug effects*; D006801:Humans; D008297:Male; D009503:Neutropenia / Q000151:congenital* / Q000188:drug therapy* / Q000473:pathology; D011994:Recombinant Proteins
D011994:Recombinant Proteins; D016179:Granulocyte Colony-Stimulating Factor; D016178:Granulocyte-Macrophage Colony-Stimulating Factor; D000069585:Filgrastim