A new aspect of gastric metaplasia in Crohn's disease: bidirectional (foveolar and pyloric) differentiation in so-called 'pyloric metaplasia' in the ileum.
Mucus-secreting cells found at the site of ileac ulceration in Crohn's disease have been described as 'pyloric metaplasia'. Using mucin-histochemical methods and immunohistochemical stainings for Ki-67 antigen and foveolar-type mucin (M1) of the stomach, the characteristics of this type of metaplasia were studied in surgically resected ileac specimens from two Japanese patients with Crohn's disease. Not only pyloric-type cells but also foveolar-type cells were demonstrated; often displaying an organoid growth of the normal stomach mucosa. Stem cells of the ileac crypt may differentiate potentially to intestinal-, pyloric- and also to foveolar-type cells. The term 'pyloric metaplasia' is not appropriate and 'gastric metaplasia' should be used when describing this type of metaplasia.
Kushima
R
R
Borchard
F
F
Hattori
T
T
D000328:Adult; D000951:Antigens, Neoplasm / Q000032:analysis; D002454:Cell Differentiation; D003424:Crohn Disease / Q000473:pathology*; D006801:Humans; D007082:Ileum / Q000737:chemistry / Q000473:pathology*; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000032:analysis; D008297:Male; D008679:Metaplasia / Q000473:pathology; D009077:Mucins / Q000032:analysis; D013270:Stomach / Q000737:chemistry / Q000473:pathology*
D000951:Antigens, Neoplasm; D019394:Ki-67 Antigen; D009077:Mucins; C042384:gastro-intestinal mucus-associated antigens