Familial spastic paraplegia: evidence for a fourth locus.
Autosomal dominant familial spastic paraparesis (AD-FSP) is a genetically heterogeneous disorder of the central nervous system characterized by a progressive spasticity of the legs. One gene causing AD-FSP (FSP1) has recently been mapped to chromosome 14q, another gene (FSP2) to chromosome 2p, and a third gene (FSP3) to chromosome 15q. We now report a large Dutch family with AD-FSP without linkage to any of these chromosomes, providing evidence for a fourth locus (FSP4).
Bruyn
R P
RP
Department of Neurology, Oudenryn Hospital, Utrecht, The Netherlands.
van Veen
M M
MM
Kremer
H
H
Scheltens
P H
PH
Padberg
G W
GW
D000328:Adult; D000368:Aged; D002869:Chromosome Aberrations / Q000235:genetics*; D025063:Chromosome Disorders; D002874:Chromosome Mapping; D002883:Chromosomes, Human, Pair 14; D002884:Chromosomes, Human, Pair 15; D002889:Chromosomes, Human, Pair 2; D005260:Female; D005799:Genes, Dominant / Q000235:genetics*; D008040:Genetic Linkage / Q000235:genetics; D006801:Humans; D008297:Male; D018895:Microsatellite Repeats / Q000235:genetics; D008875:Middle Aged; D009426:Netherlands; D010375:Pedigree; D016133:Polymerase Chain Reaction; D015419:Spastic Paraplegia, Hereditary / Q000235:genetics*