Cytomegalovirus infections and anti-GM2 antibodies in Guillain-Barré syndrome.
To investigate whether antecedent cytomegalovirus (CMV) infections in patients with Guillain-Barré syndrome are associated with the presence of specific antiganglioside antibodies, acute phase serum samples from 130 patients with Guillain-Barré syndrome and 200 controls were tested. Anti-GM2 IgM antibodies were found more often in patients with Guillain-Barré syndrome with CMV infection (22%) than in patients without the infection (2%) (P = 0.003). CMV infections may elicit anti-GM2 antibodies in susceptible patients, which may contribute to the pathogenesis of Guillain-Barré syndrome associated with CMV.
Jacobs
B C
BC
Department of Neurology, University Hospital Dijkzigt and Erasmus University, Rotterdam, The Netherlands.
van Doorn
P A
PA
Groeneveld
J H
JH
Tio-Gillen
A P
AP
van der Meché
F G
FG
D002855:Chromatography, Thin Layer; D003586:Cytomegalovirus Infections / Q000150:complications*; D004797:Enzyme-Linked Immunosorbent Assay; D005678:G(M2) Ganglioside / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D007075:Immunoglobulin M / Q000276:immunology; D011129:Polyradiculoneuropathy / Q000209:etiology* / Q000276:immunology*
D007074:Immunoglobulin G; D007075:Immunoglobulin M; D005678:G(M2) Ganglioside