[Metabolism of angiotensin I in placenta tissue].
OBJECTIVE
To explore whether placenta tissue could produce angiotensin I and the metabolism pathway of angiotensin I in placenta.


METHODS
Placenta tissues from 6 term pregnant women without any complication were cultured in vitro for 1 to 6 days, the angiotensin I concentrations in the medium were measured by radioimmunoassay in the first, second, fourth and sixth day. 5 to 500 mumol/l, captopril were added to the culture medium and the concentrations of angiotensin I were measured at the same times to observe the effect of angiotensin converting enzyme on the production of angiotensin I.


RESULTS
The concentration of angiotensin I in the placenta culture medium increased with the culture time. There were no significant differences in the concentrations, when captopril was added.


CONCLUSIONS
The placenta tissue can produce angiotensin I and its production does not depend on the angiotensin converting enzyme.
Wang
Q
Q
Peking Union Medical College Hospital, Beijing.
Shun
N
N
Zhang
D
D
D000328:Adult; D000804:Angiotensin II / Q000378:metabolism*; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology; D002216:Captopril / Q000494:pharmacology; D002478:Cells, Cultured; D005260:Female; D006801:Humans; D010920:Placenta / Q000166:cytology / Q000378:metabolism*; D011247:Pregnancy
D000806:Angiotensin-Converting Enzyme Inhibitors; D000804:Angiotensin II; D002216:Captopril