title: Nocturnal ophthalmic arterial hemodynamics in primary open-angle glaucoma.
abstract: OBJECTIVE
  Recent studies have found nocturnal reductions in systemic arterial blood pressure associated with progressive visual field loss in glaucoma. Although ocular ischemia has been hypothesized to link these two phenomena, it remains unknown if perfusion of the eye is reduced during the night in patients with glaucoma.
  
  
  METHODS
  Nine patients with primary open-angle glaucoma (POAG) and stable visual fields who were free from systemic hypertension, as well as nine age- and gender-matched controls, were studied at 9:00 P.M., and then during sleep at 12:00, 3:00, and 6:00 A.M. Systemic blood pressure, intraocular pressure (IOP), and color Doppler imaging (CDI) of the ophthalmic artery were measured at each time.
  
  
  RESULTS
  Arterial blood pressure and ophthalmic artery peak systolic and end-diastolic velocities were similar and were unchanged over time, in both groups. In contrast, the ophthalmic arterial resistance index decreased as the night progressed (p < 0.05), identically in controls and patients. In patients with glaucoma, CDI indices were independent of changes in arterial pressure, IOP, or calculated ocular perfusion pressure.
  
  
  CONCLUSIONS
  Patients with POAG characterized by stable visual fields who were free from systemic hypertension exhibited normal ophthalmic arterial hemodynamics at night; there was no evidence of ocular ischemia or vasoconstriction.
authors.affiliation: Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, USA.
authors.forename: A
authors.initials: A
authors.lastname: Harris
authors.forename: G
authors.initials: G
authors.lastname: Spaeth
authors.forename: R
authors.initials: R
authors.lastname: Wilson
authors.forename: M
authors.initials: M
authors.lastname: Moster
authors.forename: R
authors.initials: R
authors.lastname: Sergott
authors.forename: B
authors.initials: B
authors.lastname: Martin
mesh_terms: D001794:Blood Pressure / Q000502:physiology; D002940:Circadian Rhythm / Q000502:physiology*; D005260:Female; D005902:Glaucoma, Open-Angle / Q000503:physiopathology*; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology; D008297:Male; D008875:Middle Aged; D009880:Ophthalmic Artery / Q000000981:diagnostic imaging / Q000503:physiopathology*; D018615:Ultrasonography, Doppler, Color / Q000379:methods; D014655:Vascular Resistance