Sesamol as an inhibitor of growth and lipid metabolism in Mucor circinelloides via its action on malic enzyme.
Sesamol, a nonoil component of sesame seed oil, inhibited growth, fatty acid synthesis, and desaturation by Mucor circinelloides in vivo. Although sesamol also inhibited the growth of other fungi and yeasts, its effect on the lipid metabolism of M. circinelloides was exceptional. An enzymological study demonstrated that sesamol affected lipid synthesis primarily by the inhibition of malic enzyme activity, thereby limiting the NADPH supply for fatty acid synthesis and desaturation. Sesamol itself had no inhibitory effect on malic enzyme activity in vitro. A metabolite of sesamol is therefore probably responsible for the in vivo effects of sesamol on lipid metabolism.
Wynn
J P
JP
Department of Biological Sciences, University of Hull, United Kingdom. j.p.wynn@biosci.hull.ac.uk
Kendrick
A
A
Ratledge
C
C
D000975:Antioxidants / Q000494:pharmacology; D052117:Benzodioxoles; D002396:Catechols / Q000737:chemistry / Q000494:pharmacology; D004149:Dioxoles / Q000494:pharmacology; D005658:Fungi / Q000187:drug effects / Q000378:metabolism; D050356:Lipid Metabolism; D008291:Malate Dehydrogenase / Q000187:drug effects*; D009089:Mucor / Q000187:drug effects / Q000254:growth & development* / Q000378:metabolism*; D010636:Phenols / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D015003:Yeasts / Q000187:drug effects / Q000378:metabolism
D000975:Antioxidants; D052117:Benzodioxoles; D002396:Catechols; D004149:Dioxoles; D010636:Phenols; C025583:sesamol; D008291:Malate Dehydrogenase; C031917:malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+); C040539:1,3-benzodioxole; C034221:catechol