title: Airborne (1-->3)-beta-D-glucan and airway disease in a day-care center before and after renovation.
abstract: Changes in symptoms and airway responsiveness among persons who worked in a day-care center that had microbial growth problems were assessed before and after renovation. Before and after the building renovation, the investigators used the Limulus assay with (1-->3)-beta-D-glucan-specific lysate to measure airborne levels of (1-->3)-beta-D-glucan, a cell-wall component of molds. Airway responsiveness and subjective symptoms were measured among 14 female employees with a methacholine test and a standardized questionnaire. After the renovation, (1-->3)-beta-D-glucan-glucan levels decreased from 11.4 to 1.4 ng/m3. The number of persons who had increased airway responsiveness decreased after the renovation. Two employees developed a classical allergy to cat and pollen during the observation period. Although the study included only a few subjects and was based on only one day-care center, the data suggest that (1-->3)-beta-D-glucan may be related to airways inflammation caused by indoor air pollution.
authors.affiliation: Department of Environmental Medicine, University of Gothenburg, Sweden.
authors.forename: R
authors.initials: R
authors.lastname: Rylander
mesh_terms: D000328:Adult; D000393:Air Pollutants / Q000032:analysis*; D016902:Air Pollution, Indoor / Q000009:adverse effects / Q000032:analysis; D001991:Bronchitis / Q000175:diagnosis / Q000209:etiology*; D002648:Child; D002656:Child Day Care Centers; D005160:Facility Design and Construction; D005260:Female; D005936:Glucans / Q000032:analysis*; D006801:Humans; D008875:Middle Aged; D009784:Occupational Diseases / Q000175:diagnosis / Q000209:etiology*; D011795:Surveys and Questionnaires
chemical_list: D000393:Air Pollutants; D005936:Glucans