title: The plakin family: versatile organizers of cytoskeletal architecture.
abstract: Desmoplakin, plectin, bullous pemphigoid antigen 1 and envoplakin are four sequence-related proteins--recently named the plakin family--that localize to intermediate filaments and filament attachment sites at the plasma membrane. New interest in the plakins has been stimulated by the discoveries that they can link different cytoskeletal elements together and that loss of plakin function can cause diseases of the skin and other tissues.
authors.affiliation: Keratinocyte Laboratory, Imperial Cancer Research Fund, London, UK.
authors.forename: C
authors.initials: C
authors.lastname: Ruhrberg
authors.forename: F M
authors.initials: FM
authors.lastname: Watt
mesh_terms: D017398:Alternative Splicing; D000818:Animals; D001324:Autoantigens / Q000235:genetics / Q000502:physiology; D002352:Carrier Proteins; D003094:Collagen; D003598:Cytoskeletal Proteins / Q000235:genetics / Q000502:physiology; D051180:Desmoplakins; D000071821:Dystonin; D006801:Humans; D007381:Intermediate Filament Proteins / Q000235:genetics / Q000502:physiology; D008565:Membrane Proteins / Q000235:genetics / Q000502:physiology; D009419:Nerve Tissue Proteins; D024041:Non-Fibrillar Collagens; D051190:Plectin; D011487:Protein Conformation; D011498:Protein Precursors / Q000235:genetics / Q000502:physiology; D012871:Skin Diseases / Q000235:genetics*; D000097805:Collagen Type XVII
chemical_list: D001324:Autoantigens; D002352:Carrier Proteins; D003094:Collagen; D003598:Cytoskeletal Proteins; D051180:Desmoplakins; D000071821:Dystonin; D007381:Intermediate Filament Proteins; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; D024041:Non-Fibrillar Collagens; D051190:Plectin; D011498:Protein Precursors; D000097805:Collagen Type XVII; C495294:DSP protein, human; C486268:DST protein, human; C495332:PLEC protein, human; C100754:envoplakin