Recent structural solutions for antibody neutralization of viruses.
Structural studies of virus-antibody interactions can offer insights into mechanisms of virus neutralization and immune escape. Crystallography and cryoelectron microscopy can reveal the structural relationship between receptor-binding sites and neutralization epitopes, as well as whether molecular rearrangements occur upon antibody binding.
Stewart
P L
PL
Dept of Molecular and Medical Pharmacology, UCLA School of Medicine 90095-1770, USA. pstewart@mail.nuc.ucla.edu
Nemerow
G R
GR
D000818:Animals; D000936:Antigen-Antibody Complex / Q000648:ultrastructure*; D005537:Aphthovirus / Q000276:immunology*; D000939:Epitopes / Q000648:ultrastructure; D006389:Hemagglutinins, Viral / Q000276:immunology; D006801:Humans; D007140:Immunoglobulin Fab Fragments / Q000276:immunology; D018799:Intercellular Adhesion Molecule-1 / Q000276:immunology; D008854:Microscopy, Electron; D009975:Orthomyxoviridae / Q000276:immunology*; D012229:Rhinovirus / Q000276:immunology*
D000936:Antigen-Antibody Complex; D000939:Epitopes; D006389:Hemagglutinins, Viral; D007140:Immunoglobulin Fab Fragments; D018799:Intercellular Adhesion Molecule-1