[A pathological survey of the therapeutic effect on experimental hypoxic-ischemic encephalopathy].
Rat models of the acute and recuperative phases of hypoxic ischemic encephalopathy (HIE) were established beginning by the 7th day after birth through ischemia and hypoxia. The prophylatic and therapeutic effects on experimental HIE were studied by the application of radix salviae miltiorrhizae, flunarizine and hyperbaric oxygen. Experimental data indicated that among these measures, radix salviae miltiorrhizae gave a better result and the pathological change in the prophylactic and therapeutic groups particularly the result of the latter one were light serious than those of the control group.
Zhang
L
L
Capital Institute of Pediatrics, Beijing.
Cai
L
L
Zhang
W
W
D000818:Animals; D001284:Atrophy; D001921:Brain / Q000473:pathology*; D001927:Brain Diseases / Q000188:drug therapy / Q000473:pathology*; D002121:Calcium Channel Blockers / Q000627:therapeutic use; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005444:Flunarizine / Q000627:therapeutic use; D000860:Hypoxia / Q000150:complications*; D009929:Organ Size / Q000187:drug effects; D010936:Plant Extracts; D051381:Rats; D017208:Rats, Wistar; D027561:Salvia miltiorrhiza; D014665:Vasodilator Agents / Q000627:therapeutic use*
D002121:Calcium Channel Blockers; D004365:Drugs, Chinese Herbal; D010936:Plant Extracts; D014665:Vasodilator Agents; D005444:Flunarizine