Radiofrequency capacitive hyperthermia for unresectable hepatic cancers.
Radiofrequency capacitive hyperthermia combined with intra-arterial chemotherapy or chemoembolization was performed in 45 patients with unresectable hepatic cancer. Intratumor temperature was measured in 26 (57.8%) of the 45 patients. The overall mean maximum core temperature (Tmax) was 41.3 +/- 0.3 degrees C (mean +/- SE), and the Tmax was > or = 42 degrees C in nine tumors (34.6%). The tumor temperature rise was related to the power applied, embolization with degradable starch microspheres, and obstruction of the portal vein. The overall response rate was 31.1% (14/45). The response rate was 55.6% when Tmax was > or = 42 degrees C; although this was higher than the response rate of 11.8% achieved with Tmax < 42 degrees C, the difference was not significant. There were no serious adverse effects of hyperthermia.
Yamamoto
K
K
Department of Radiology, Kansai Medical University, Osaka, Japan.
Tanaka
Y
Y
D000328:Adult; D000368:Aged; D000903:Antibiotics, Antineoplastic / Q000009:adverse effects / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D004317:Doxorubicin / Q000009:adverse effects / Q000627:therapeutic use; D004621:Embolization, Therapeutic; D006801:Humans; D006979:Hyperthermia, Induced / Q000009:adverse effects / Q000379:methods*; D007459:Iodized Oil / Q000627:therapeutic use; D008113:Liver Neoplasms / Q000401:mortality / Q000628:therapy*; D008863:Microspheres; D008875:Middle Aged; D016685:Mitomycin / Q000009:adverse effects / Q000627:therapeutic use; D011846:Radio Waves; D016896:Treatment Outcome
D000903:Antibiotics, Antineoplastic; D016685:Mitomycin; D007459:Iodized Oil; D004317:Doxorubicin