Charlotte Friend Memorial Lecture: murine leukemia virus (MuLV) tumorigenesis.
Recent analysis of over 500 lymphomas occurring in NFS.V mice, congenic for Akv-type ecotropic MuLV structural genes, has revealed that about 90% are of B cell lineage as determined by demonstration of clonal rearrangements of Ig heavy chain genes, phenotyping by immunocytochemistry or cytofluorometric analysis, and by site and morphology of tumor. At least 40% of the B cell lymphomas were found to have their origin in the splenic marginal zone, a site only once before described for mouse lymphomas. Clonal somatic integrations of ecotropic MuLV occurred in 85% of tumors.
Hartley
J W
JW
Laboratory of Immunopathology, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, USA.
Chattopadhyay
S K
SK
Morse
H C
HC
Fredrickson
T N
TN
D000818:Animals; D015321:Gene Rearrangement; D007143:Immunoglobulin Heavy Chains / Q000235:genetics; D016130:Immunophenotyping; D009052:Leukemia Virus, Murine; D007942:Leukemia, Experimental / Q000503:physiopathology / Q000821:virology*; D008223:Lymphoma / Q000503:physiopathology / Q000821:virology*; D016393:Lymphoma, B-Cell / Q000276:immunology / Q000821:virology; D016399:Lymphoma, T-Cell / Q000821:virology; D051379:Mice; D008815:Mice, Inbred Strains; D012192:Retroviridae Infections / Q000503:physiopathology / Q000821:virology*; D014412:Tumor Virus Infections / Q000503:physiopathology / Q000821:virology*
D007143:Immunoglobulin Heavy Chains