title: Antigenic variability of an immunodominant region (239-261) of the surface glycoprotein of HTLV-I.
abstract: In the 239-261 region of the surface glycoprotein of HTLV-I, we delineated five epitopes recognized by antibodies present in sera from HTLV-I infected patients. Three epitopes are located between the amino acids 252 and 261, one is of a linear type and the two others of a conformational type. One epitope is comprised between amino acids 244 and 249. The last epitope described lies between the amino acids 244 and 257 and strictly requires the presence of a serine at position 250 for its recognition. When patients are infected by viral isolates presenting a substitution of the serine at position 250 by a proline, no antibodies recognizing the 244-257 region could be found. Altogether, our data demonstrate that the immunodominant 239-261 region is complex and is subject to antigenic variability.
authors.affiliation: INSERM U328, Institut Bergonié, Bordeaux, France.
authors.forename: D
authors.initials: D
authors.lastname: Londos-Galgliardi
authors.forename: R
authors.initials: R
authors.lastname: Dalibart
authors.forename: M
authors.initials: M
authors.lastname: Goetz
authors.forename: P
authors.initials: P
authors.lastname: Dalbon
authors.forename: B
authors.initials: B
authors.lastname: Guillemain
mesh_terms: D000595:Amino Acid Sequence; D000940:Antigenic Variation; D000939:Epitopes / Q000032:analysis / Q000737:chemistry; D015481:HTLV-I Antibodies / Q000096:biosynthesis; D015490:HTLV-I Infections / Q000276:immunology*; D015368:Human T-lymphotropic virus 1 / Q000235:genetics / Q000276:immunology* / Q000472:pathogenicity; D006801:Humans; D008969:Molecular Sequence Data; D010455:Peptides / Q000138:chemical synthesis / Q000276:immunology; D017354:Point Mutation; D011392:Proline; D012694:Serine
chemical_list: D000939:Epitopes; D015481:HTLV-I Antibodies; D010455:Peptides; D012694:Serine; D011392:Proline