Respiratory control index of mitochondria isolated from regenerating rat liver.
Mitochondria were isolated from regenerating rat liver 12, 24 and 48 h after partial hepatectomy. The "State 3" and "State 4" respiration were measured in the presence of succinate. The P/O quotient and respiratory control index (RCI) were calculated. The experimental data showed that the partial uncoupling of oxidative phosphorylation in regenerating liver mitochondria occurring in the early period of regeneration is partly due to free fatty acids.
Svátková
R
R
Department of Physiology, Faculty of Medicine, Charles University, Hradec Králové, Czech Republic.
Cervinková
Z
Z
Kalous
M
M
Rauchová
H
H
Drahota
Z
Z
D000818:Animals; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D006498:Hepatectomy; D008115:Liver Regeneration; D008297:Male; D008930:Mitochondria, Liver / Q000378:metabolism*; D010085:Oxidative Phosphorylation; D010101:Oxygen Consumption; D051381:Rats; D017208:Rats, Wistar; D012710:Serum Albumin, Bovine / Q000494:pharmacology; D013386:Succinates / Q000378:metabolism; D019802:Succinic Acid
D005230:Fatty Acids, Nonesterified; D013386:Succinates; D012710:Serum Albumin, Bovine; D019802:Succinic Acid