Periodontal regeneration in naturally occurring Class II furcation defects in beagle dogs after guided tissue regeneration with bioabsorbable barriers.
THE EFFICACY OF A BIOABSORBABLE polylactic acid based barrier was evaluated using naturally occurring buccal Class II furcation defects in beagle dogs. Sixteen furcation sites (8 control and 8 experimental) were treated in 6 adult animals. After full thickness flap reflection, exposed furcations and root surfaces were thoroughly root planed. In experimental sites a customized barrier was formed and fitted to cover the defect. Surgical flaps were replaced slightly coronal to the cemento-enamel junction. Animals were sacrificed at 6 months and specimens processed for histologic evaluation. Histologic and histometric analyses were done using 6 micrograms step serial sections in the buccal-lingual plane, corresponding to the buccal-lingual extent of the furcation. Results were: mean total defect experimental sites 1.92 mm; control sites 1.47 mm. Mean new cementum formation experimental sites 1.36 mm (71% of initial defect); control sites 0.25 mm (17% of initial defect). Mean new bone formation experimental sites 1.42 mm (74% of initial defect); control sites 0.20 mm (14% of initial defect). Mean junctional epithelium formation experimental sites 0.42 mm (22% of initial defect); control sites 1.21 mm (82% of initial defect). Statistical analysis demonstrated significant differences in all healing parameters favoring experimental (barrier-treated) sites. In this model, regeneration (new bone, cementum, and periodontal ligament) of 71% of the original defect in experimental sites and only 14% in control sites demonstrated a response that highly favored use of the barrier.
Bogle
G
G
Loma Linda University, Department of Periodontics, CA, USA.
Garrett
S
S
Stoller
N H
NH
Swanbom
D D
DD
Fulfs
J C
JC
Rodgers
P W
PW
Whitman
S
S
Dunn
R L
RL
Southard
G L
GL
Polson
A M
AM
D016301:Alveolar Bone Loss / Q000601:surgery; D000818:Animals; D001673:Biodegradation, Environmental; D001861:Bone Regeneration; D003739:Dental Cementum / Q000502:physiology; D004285:Dogs; D004846:Epithelial Attachment / Q000502:physiology; D005260:Female; D017823:Furcation Defects / Q000473:pathology / Q000601:surgery*; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods*; D019344:Lactic Acid; D008567:Membranes, Artificial; D010513:Periodontal Ligament / Q000502:physiology; D011091:Polyesters; D011108:Polymers; D012038:Regeneration
D008567:Membranes, Artificial; D011091:Polyesters; D011108:Polymers; D019344:Lactic Acid; C033616:poly(lactide)