[Tumor lysis syndrome after treatment for mediastinal non-Hodgkin's lymphoma].
An 18-year man was admitted to the hospital because of acute dyspnea. Roentgenological examination revealed a large anterior mediastinal tumor. Histologic examination of a specimen from a cervical lymph node yielded a diagnosis of non-Hodgkin's lymphoma of, diffuse, large, T-cell type. Acute respiratory failure and a massive pleural effusion developed, and mechanical ventilation was begun. Chemotherapy with adriamycin, vincristine, cyclophosphamide, and prednisolone resulted in rapid shrinking of the mass. Acute renal failure developed because of hypoperfusion of the kidney caused by acute circulatory failure and the tumor lysis syndrome, and rapid increases in the concentrations of lactate dehydrogenase, creatine phosphokinase, and uric acid in serum after the tumor collapsed. Mediastinal malignant lymphoma often forms a bulky mass, and effective chemotherapy, while it can prolong survival, may also cause the tumor lysis syndrome.
Kaneki
T
T
First Department of Internal Medicine, Shinshu University School of Medicine, Japan.
Hachiya
T
T
Hayano
T
T
Koizumi
T
T
Kubo
K
K
Harada
T
T
Kawashima
A
A
Sekiguchi
M
M
Honda
T
T
Maruyama
Y
Y
D000208:Acute Disease; D058186:Acute Kidney Injury / Q000209:etiology; D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003520:Cyclophosphamide / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy*; D008297:Male; D008479:Mediastinal Neoplasms / Q000188:drug therapy*; D011241:Prednisone / Q000008:administration & dosage; D012131:Respiratory Insufficiency / Q000209:etiology; D015275:Tumor Lysis Syndrome / Q000209:etiology*; D014750:Vincristine / Q000008:administration & dosage
D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011241:Prednisone