title: Middle-ear disease in children exposed prenatally to polychlorinated biphenyls and polychlorinated dibenzofurans.
abstract: During 1978 and 1979, an episode of poisoning from ingestion of rice oil contaminated with polychlorinated biphenyls and polychlorinated dibenzofurans occurred in central Taiwan. We followed-up children who had been born between June 1978 and March 1985, as well as matched unexposed children. The mothers of exposed children had consumed contaminated oils before the children were born. In 1993, otolaryngologists examined the middle ear of each child with a pneumatic otoscope, and they measured the middle-ear pressure by tympanometry with a Rion RS20 impedance audiometer. The exposed children had a significantly higher prevalence of middle-ear diseases than their matched controls. The exposed children who had ear diseases had higher serum levels of 2,3,4,7,8-pentachloro- and 1,2,3,4,7,8-hexachloro-dibenzofurans than the children who did not have similar diseases. Therefore, in this study, children exposed to polychlorinated biphenyls and polychlorinated dibenzofurans had a higher incidence of middle-ear diseases than their controls.
authors.affiliation: Department of Otolaryngology, National Cheng Kung University Medical College, Tainan, Taiwan, Republic of China.
authors.forename: W Y
authors.initials: WY
authors.lastname: Chao
authors.forename: C C
authors.initials: CC
authors.lastname: Hsu
authors.forename: Y L
authors.initials: YL
authors.lastname: Guo
mesh_terms: D001572:Benzofurans / Q000009:adverse effects* / Q000097:blood; D002648:Child; D000072338:Dibenzofurans, Polychlorinated; D004427:Ear Diseases / Q000097:blood / Q000139:chemically induced / Q000175:diagnosis / Q000453:epidemiology; D004432:Ear, Middle / Q000187:drug effects*; D005260:Female; D005506:Food Contamination; D006801:Humans; D008297:Male; D012275:Oryza / Q000506:poisoning; D010938:Plant Oils / Q000506:poisoning; D011078:Polychlorinated Biphenyls / Q000009:adverse effects* / Q000097:blood; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D015995:Prevalence; D013624:Taiwan / Q000453:epidemiology
chemical_list: D001572:Benzofurans; D000072338:Dibenzofurans, Polychlorinated; D010938:Plant Oils; D011078:Polychlorinated Biphenyls