title: Anti-PL 4 in patients with systemic lupus erythematosus with severe renal and haematological disease.
abstract: Anti-PL 4 is an autoantibody which binds to a 150 kDa polypeptide and is found in approximately 1% of SLE sera. The clinical and laboratory features of 16 patients who have had anti-PL 4 detected in their serum are presented. Anti-PL 4 is highly specific for SLE (100%) and identifies a population of patients who typically develop severe renal (75%) and haematological disease (100%).
authors.affiliation: Rheumatology Unit, RPMS, Hammersmith Hospital, London, UK.
authors.forename: C
authors.initials: C
authors.lastname: Marguerie
authors.forename: C C
authors.initials: CC
authors.lastname: Bunn
authors.forename: C M
authors.initials: CM
authors.lastname: Black
authors.forename: A K
authors.initials: AK
authors.lastname: So
authors.forename: M J
authors.initials: MJ
authors.lastname: Walport
mesh_terms: D000918:Antibody Specificity; D001323:Autoantibodies / Q000032:analysis*; D015415:Biomarkers / Q000032:analysis; D006682:HLA-DP Antigens / Q000276:immunology; D006402:Hematologic Diseases / Q000175:diagnosis; D006801:Humans; D007674:Kidney Diseases / Q000175:diagnosis / Q000276:immunology; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000276:immunology*; D011233:Precipitin Tests
chemical_list: D001323:Autoantibodies; D015415:Biomarkers; D006682:HLA-DP Antigens