Congenital hemangiopericytoma/infantile myofibromatosis: radical surgery versus a conservative "wait and see" approach.
Infantile/congenital hemangiopericytoma, although sharing many similar histological features with adult hemangiopericytoma, has a much better prognosis. Nevertheless, most cases described in the literature were pursued by radical surgery with or without adjuvant chemotherapy. We describe a neonate who presented with a huge mass in the right gluteus, 6 x 5 x 4 cm, and a small ventral abdominal mass. The masses were confirmed on biopsy according to light microscopy, immunohistochemistry, and electron microscopy as congenital hemangiopericytoma. They shrank spontaneously within 2 weeks and vanished within 2 months. We present a hypothesis that masses appearing in the neonatal period with this histology and with no life-endangering pressure on vital organs should routinely be dealt with conservatively.
Toren
A
A
Pediatric Hemato/Oncology Department, Chaim Sheba Medical Center, Tel-Hashomer, Israel.
Perlman
M
M
Polak-Charcon
S
S
Avigad
I
I
Katz
M
M
Kuint
Y
Y
Rechavi
G
G
D000328:Adult; D001706:Biopsy; D006393:Hemangiopericytoma / Q000151:congenital* / Q000473:pathology / Q000601:surgery / Q000628:therapy* / Q000648:ultrastructure; D006801:Humans; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging; D008854:Microscopy, Electron; D018224:Myofibromatosis / Q000151:congenital* / Q000473:pathology / Q000601:surgery / Q000628:therapy*; D009365:Neoplasm Regression, Spontaneous