[TCR repertoire of autoreactive T cells in autoimmune disorders].
In human autoimmune diseases such as rheumatoid arthritis, Sjögren's syndrome, and multiple sclerosis, it has been clarified that autoreactive T cells play a crucial role in the generation of autoimmune disorders. Immunohistochemical studies have shown that most infiltrating lymphocytes are CD4 positive alpha beta T cells. Recent studies with polymerase chain reaction (PCR) provides evidence about the T cell receptor (TCR) V beta and V alpha genes on their T cells. Sequence analysis of the complementarity determining region 3 (CDR3), which is a central portion for recognition of antigens by T cells, indicates some conserved amino acid motifs, supporting the notion that infiltrating T cells recognize relatively few epitopes on autoantigen.
Sumida
T
T
Division of Rheumatology and Molecular Immunology, St. Marianna University School of Medicine.
Matsumoto
I
I
Maeda
T
T
D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology*; D000939:Epitopes / Q000276:immunology; D006801:Humans; D016133:Polymerase Chain Reaction; D018807:Polymorphism, Single-Stranded Conformational; D011948:Receptors, Antigen, T-Cell / Q000032:analysis* / Q000235:genetics; D013601:T-Lymphocytes / Q000276:immunology*
D000939:Epitopes; D011948:Receptors, Antigen, T-Cell