title: Multifocal osteosarcoma in a patient with Fanconi anemia.
abstract: OBJECTIVE
  The purpose of this report is to present a case of multifocal osteosarcoma in a patient with Fanconi anemia.
  
  
  METHODS
  A nine year old girl with known Fanconi anemia presented with a pathologic femur fracture. Imaging studies confirmed soft tissue and bony involvement in the femur, ipsilateral tibia, and possibly contralateral femur.
  
  
  RESULTS
  Biopsy and subsequent amputation confirmed the presence of classic osteosarcoma in the involved femur and ipsilateral tibia. The patient died seven months later of pulmonary failure secondary to metastases.
  
  
  CONCLUSIONS
  Fanconi anemia is known to be associated with malignancies such as leukemias. We report a new association of Fanconi anemia with osteosarcoma.
authors.affiliation: Oregon Health Sciences University, Portland, USA.
authors.forename: S
authors.initials: S
authors.lastname: Levinson
authors.forename: K A
authors.initials: KA
authors.lastname: Vincent
mesh_terms: D001859:Bone Neoplasms / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D002648:Child; D005199:Fanconi Anemia / Q000150:complications*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000556:secondary; D012516:Osteosarcoma / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D011859:Radiography