[Clinical evaluation of radiation complications with various methods of radiotherapy for vaginal cancer].
The investigation was concerned with complications development in 133 cases of primary vaginal carcinoma (VC) who had been treated with combined (distance and contact treatment) or low-dosage (LD), medium-dosage (MD) or high-dosage (HD) contact irradiation. Time-dose-fractionation (TDF), cumulative radiation effect (CRE) and linear-quadratic (LQ) ("extrapolated dose of response") were used to evaluate normal tissue response. Early- and late-onset radiation injuries of vaginal mucosa, urinary bladder and rectum were compared vis-a-vis dosage which was calculated on the basis of HDF model. Dosage exceeding the limits of connective tissue tolerance was responsible for the development of early-onset epithelitis, cystitis and rectitis in cases of LD- or MD-brachytherapy of vaginal carcinoma or when the latter was conducted in conjunction with distance therapy. However, early-onset epithelitis and cystitis might appear when dosage remained within tolerance limits. This occurred as a result of HD-contact treatment or when the latter was used as a component of combined therapy. Most late-onset moist vaginal epithelites, rectites and recto-vaginal fistuals were caused by dosage in excess of tolerance. Late- and early-onset vaginal epithelitis was observed with tolerable dosage, too, if HD-brachytherapy alone was used or as a component of combined treatment.
Kanaev
S V
SV
Turkevich
V G
VG
D004307:Dose-Response Relationship, Radiation; D005260:Female; D006801:Humans; D011832:Radiation Injuries / Q000209:etiology*; D011878:Radiotherapy / Q000009:adverse effects; D011879:Radiotherapy Dosage; D014625:Vaginal Neoplasms / Q000532:radiotherapy*