Cardiorespiratory and neuromuscular effects of O-ethyl S--2-(diisopropylamino) ethyl- methylphosphonothioate (VX) in rats.
Dube
S N
SN
Divisions of Pharmacology and Toxicology, Synthetic Chemistry Defence Research and Development Establishment, Jhansi Road, Gwalior 474 002, India.
Mazumder
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PK
Kumar
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D
D000315:Adrenalectomy; D000818:Animals; D001285:Atropine / Q000008:administration & dosage / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D001980:Bronchi / Q000187:drug effects / Q000378:metabolism; D016084:Bronchoconstriction / Q000187:drug effects; D002319:Cardiovascular System / Q000187:drug effects*; D002339:Carotid Arteries / Q000187:drug effects / Q000378:metabolism; D002619:Chemical Warfare Agents / Q000633:toxicity*; D002800:Cholinesterase Inhibitors / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D018482:Muscle, Skeletal / Q000187:drug effects / Q000378:metabolism; D009469:Neuromuscular Junction / Q000187:drug effects*; D009946:Organothiophosphorus Compounds / Q000633:toxicity*; D010276:Parasympatholytics / Q000008:administration & dosage / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013565:Sympatholytics / Q000008:administration & dosage / Q000494:pharmacology; D009435:Synaptic Transmission / Q000187:drug effects; D014043:Tolazoline / Q000008:administration & dosage / Q000494:pharmacology; D014132:Trachea / Q000187:drug effects / Q000378:metabolism; D014628:Vagotomy
D001285:Atropine; D002619:Chemical Warfare Agents; D002800:Cholinesterase Inhibitors; D009946:Organothiophosphorus Compounds; D010276:Parasympatholytics; D013565:Sympatholytics; D014043:Tolazoline; C009680:VX-agent