Cytotoxic monocytes in the blood of HIV type 1-infected subjects destroy targeted T cells in a CD95-dependent fashion.
HIV-1 infection changes the functional balance of macrophages in the body; it inhibits the development of macrophages capable of costimulating T cell responses and it favors the development of macrophages that kill T cells with which they form cellular conjugates. Cytotoxic macrophages destroy CD4 T cells, which they target through CD4-reactive immune-complexed HIV-1 envelope molecules on a large scale. They also destroy T cells that they target through presented antigen or mitogen. We show here that cytotoxic macrophages destroy their cellular targets at least partially in a CD95-dependent process in which T cells first modulate expression of most of their membrane receptors and subsequently die.
Orlikowsky
T
T
Department of Microbiology and Immunology, New York Medical College, Valhalla 10595, USA.
Wang
Z Q
ZQ
Dudhane
A
A
Horowitz
H
H
Riethmuller
G
G
Hoffmann
M K
MK
D000328:Adult; D017209:Apoptosis / Q000276:immunology; D015415:Biomarkers; D018106:CD28 Antigens / Q000378:metabolism; D015704:CD4 Antigens / Q000276:immunology / Q000378:metabolism; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D002478:Cells, Cultured; D003602:Cytotoxicity, Immunologic / Q000276:immunology*; D015658:HIV Infections / Q000276:immunology*; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D016130:Immunophenotyping; D008264:Macrophages / Q000276:immunology; D009000:Monocytes / Q000276:immunology*; D011948:Receptors, Antigen, T-Cell / Q000378:metabolism; D015854:Up-Regulation / Q000276:immunology; D019014:fas Receptor / Q000276:immunology*
D015415:Biomarkers; D018106:CD28 Antigens; D015704:CD4 Antigens; D011948:Receptors, Antigen, T-Cell; D019014:fas Receptor