Lipopolysaccharide-induced fever in rats prolonged by a needle prick.
We studied the effect of an abdominal prick with a needle on LPS-induced fever in freely-moving rats. LPS was injected intraperitoneally by the following 3 methods: 1) through a hypodermic needle pricked into the abdominal cavity, 2) through a catheter chronically indwelt in the abdominal cavity, and 3) through a catheter chronically indwelt in the abdominal cavity immediately after an abdominal prick was made. In the second method, core body temperature (Tb) began to rise about 1 h after the injection, reaching a maximal level at around 2.5 h and decreasing gradually thereafter. In the first and third methods, Tb rose again to make a second peak after making the first peak of fever. This was the same when LPS was injected through a hypodermic needle pricked into the abdominal cavity under restrained condition. These results suggest that the abdominal prick with a needle is responsible for the development of the second peak (or prolongation) of LPS-fever in rats.
Sugimoto
N
N
Department of Physiology, School of Medicine, Kanazawa University, Japan.
Shido
O
O
Sakurada
S
S
Nagasaka
T
T
D000005:Abdomen / Q000502:physiology; D000007:Abdominal Injuries / Q000503:physiopathology; D000704:Analysis of Variance; D000818:Animals; D001831:Body Temperature / Q000502:physiology*; D002408:Catheters, Indwelling; D005334:Fever / Q000139:chemically induced*; D007274:Injections, Intraperitoneal; D008070:Lipopolysaccharides / Q000008:administration & dosage / Q000633:toxicity*; D008297:Male; D016602:Needlestick Injuries / Q000503:physiopathology*; D010529:Peritoneal Cavity / Q000293:injuries / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar
D008070:Lipopolysaccharides