title: MIB1 immunopositivity is associated with rapid regrowth of pituitary adenomas.
abstract: Pituitary adenomas are generally regarded as benign tumours, but they may recur. We identified eight patients with pituitary adenomas that showed rapid regrowth within 2 years of initial surgery. We estimated the percentage of cells in each specimen that showed positive immunostaining for MIB1 (a novel anti-Ki-67) and compared the values to those of 40 adenomas that showed no regrowth. The mean MIB1 index for 40 adenomas that showed no evidence of regrowth was 0.19 +/- 0.06%. This was significantly (p < 0.0001) lower than that for adenomas that showed rapid regrowth (1.27 +/- 0.31%), based on the initial resected specimens. Immediately after detection of rapid regrowth and in adenomas that were resistant to bromocriptine or irradiation, the MIB1 index was always greater than 1.0%. Most patients with rapidly regrowing adenomas were well controlled by radiation therapy. Our results suggest that a MIB1 index greater than 1.0% may be a useful predictor of rapid regrowth of pituitary adenomas and may be useful for planning of therapy.
authors.affiliation: Department of Neurosurgery, Hiroshima University School of Medicine, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Mizoue
authors.forename: H
authors.initials: H
authors.lastname: Kawamoto
authors.forename: K
authors.initials: K
authors.lastname: Arita
authors.forename: K
authors.initials: K
authors.lastname: Kurisu
authors.forename: A
authors.initials: A
authors.lastname: Tominaga
authors.forename: T
authors.initials: T
authors.lastname: Uozumi
mesh_terms: D000236:Adenoma / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D000324:Adrenocorticotropic Hormone / Q000032:analysis; D000328:Adult; D000911:Antibodies, Monoclonal; D014408:Biomarkers, Tumor / Q000032:analysis*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000032:analysis; D019382:Human Growth Hormone / Q000032:analysis; D006801:Humans; D007016:Hypophysectomy; D007124:Immunoenzyme Techniques; D019394:Ki-67 Antigen / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D009384:Paraneoplastic Endocrine Syndromes / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D010902:Pituitary Gland / Q000473:pathology; D010911:Pituitary Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D011237:Predictive Value of Tests; D011388:Prolactin / Q000032:analysis; D014057:Tomography, X-Ray Computed
chemical_list: D000911:Antibodies, Monoclonal; D014408:Biomarkers, Tumor; D019394:Ki-67 Antigen; D019382:Human Growth Hormone; D000324:Adrenocorticotropic Hormone; D011388:Prolactin; D005640:Follicle Stimulating Hormone