title: Human biodistribution of an ultrasound contrast agent (Quantison) by radiolabelling and gamma scintigraphy.
abstract: The biodistribution and kinetics of an air filled human serum albumin microcapsule formulation (Quantison) intended for use as an intravenous ultrasound contrast agent have been examined. 12 healthy subjects were administered with approximately 50 million microcapsules per kilogram body weight, radiolabelled with 50 MBq 123I. Imaging was performed over a period of 58 h using a large field-of-view gamma camera and the amount of labelled material present in the blood, urine and faeces measured. Imaging demonstrated that the liver was the organ with the highest uptake, with a mean uptake of 41.8% (SD 10.4%) of the administered dose 1 h following administration. The maximum uptake of the agent in the lungs was low, mean 4.0% (SD 3.4%). A small amount of uptake was visible in the bone marrow; however, this was not quantifiable. There was also evidence of minimal myocardial activity within 5 min of administration. No adverse events were observed and there were no changes in any of the individual post-study indices. The present study demonstrates the safety of Quantison. Gamma scintigraphy played a useful role in confirming the biodistribution of the agent with little lung uptake, high liver uptake and evidence of myocardial uptake.
authors.affiliation: Department of Medical Physics, University Hospital, Nottingham, UK.
authors.forename: A C
authors.initials: AC
authors.lastname: Perkins
authors.forename: M
authors.initials: M
authors.lastname: Frier
authors.forename: A J
authors.initials: AJ
authors.lastname: Hindle
authors.forename: P E
authors.initials: PE
authors.lastname: Blackshaw
authors.forename: S E
authors.initials: SE
authors.lastname: Bailey
authors.forename: J M
authors.initials: JM
authors.lastname: Hebden
authors.forename: S M
authors.initials: SM
authors.lastname: Middleton
authors.forename: M L
authors.initials: ML
authors.lastname: Wastie
mesh_terms: D000328:Adult; D000388:Air; D002214:Capsules; D003287:Contrast Media / Q000493:pharmacokinetics*; D004452:Echocardiography; D006801:Humans; D007275:Injections, Intravenous; D007457:Iodine Radioisotopes; D008297:Male; D011877:Radionuclide Imaging; D012709:Serum Albumin / Q000493:pharmacokinetics*; D014018:Tissue Distribution
chemical_list: D002214:Capsules; D003287:Contrast Media; D007457:Iodine Radioisotopes; D012709:Serum Albumin