title: Red cell survival in patients with nonalcoholic liver cirrhosis before and after distal splenorenal shunt.
abstract: We previously reported severe hemolysis in one patient immediately after distal splenorenal shunt (DSRS). The purpose of the present study was to evaluate changes in red cell survival after DSRS. In ten patients with nonalcoholic cirrhosis in whom DSRS was performed for esophageal varices, red cell survival and splenic quantitative hemodynamic studies were performed before and after DSRS. The splenic venous blood flow per unit volume (flow/volume ratio) was calculated. The red cell survival was significantly (P < 0.05) shortened after DSRS; the apparent half-life survival time (T 1/2) before and after DSRS was 24.6 +/- 5.9 (mean +/- SD) and 16.3 +/- 8.5 days, respectively. After DSRS, the spleen volume was significantly (P < 0.05) decreased, whereas the splenic venous blood flow was slightly increased. The spleen flow/volume ratio was significantly (P < 0.05) increased after DSRS. There was a significant and negative correlation (r = -0.684, P < 0.05) between the postoperative percentage change in T 1/2 and the spleen flow/volume ratio. These findings suggest that the red cell survival period is significantly decreased, after DSRS in patients with nonalcoholic cirrhosis, and that the increased splenic blood flow per unit spleen volume after DSRS may play an important role in the hemolytic reaction in the spleen after this procedure.
authors.affiliation: Second Department of Surgery, Hyogo College of Medicine, Nishinomiya, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Nishiwaki
authors.forename: H
authors.initials: H
authors.lastname: Ashida
authors.forename: A
authors.initials: A
authors.lastname: Nishioka
authors.forename: J
authors.initials: J
authors.lastname: Utsunomiya
mesh_terms: D000328:Adult; D000368:Aged; D004905:Erythrocyte Aging; D004932:Esophageal and Gastric Varices / Q000097:blood* / Q000209:etiology / Q000503:physiopathology / Q000601:surgery*; D005260:Female; D006207:Half-Life; D006439:Hemodynamics; D006801:Humans; D008103:Liver Cirrhosis / Q000097:blood* / Q000503:physiopathology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D013154:Spleen / Q000503:physiopathology; D013164:Splenorenal Shunt, Surgical