title: Aggression and schizophrenia: efficacy of risperidone.
abstract: The advent of novel antipsychotic medications has raised treatment expectations for patients with severe mental illness. In this regard, clozapine has been particularly effective in reducing aggressive behavior in patients with schizophrenia. This study compared the efficacy of risperidone and conventional antipsychotic medications in the management of hostile patients. Improvements in the level of aggression were evident over time in both treatment groups, and a similar response between risperidone and typical antipsychotics was observed. Future studies should address the relative role of typical antipsychotics, adjunctive agents, and novel antipsychotic medications in the pharmacological management of persistent aggression in patients with schizophrenia.
authors.affiliation: Northcoast Behavioral Healthcare System, Cleveland, OH 44067, USA.
authors.forename: P F
authors.initials: PF
authors.lastname: Buckley
authors.forename: Z Y
authors.initials: ZY
authors.lastname: Ibrahim
authors.forename: B
authors.initials: B
authors.lastname: Singer
authors.forename: B
authors.initials: B
authors.lastname: Orr
authors.forename: K
authors.initials: K
authors.lastname: Donenwirth
authors.forename: P S
authors.initials: PS
authors.lastname: Brar
mesh_terms: D000328:Adult; D000374:Aggression / Q000187:drug effects*; D000704:Analysis of Variance; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009820:Ohio; D011600:Psychopharmacology; D012149:Restraint, Physical; D012189:Retrospective Studies; D018967:Risperidone / Q000627:therapeutic use*; D012559:Schizophrenia / Q000150:complications* / Q000188:drug therapy*; D012934:Social Isolation; D016896:Treatment Outcome
chemical_list: D014150:Antipsychotic Agents; D018967:Risperidone