title: Urinary 1-hydroxypyrene as a marker of exposure to pyrene: an epidemiological survey on a general population group.
abstract: Urinary levels of 1-hydroxypyrene in a general adult population group are studied. Experimental data are not normally distributed; statistical analysis required a base 10 logarithmic transformation of data. The concentrations of urinary 1-hydroxypyrene measured were expressed as microgram g-1 urinary creatinine and are comparable with those reported by other authors, both for smoker and non-smoker subgroups. Multiple regression analysis shows that, for smokers, the number of cigarettes smoked per day and the body mass index (BMI) significantly influence the levels of urinary 1-hydroxypyrene expressed as microgram g-1 urinary creatinine, whereas no personal or behavioural variable (age, sex, alcohol consumption, dietary intake of pyrene, BMI) modified the 1-hydroxypyrene levels for non-smokers.
authors.affiliation: Dipartimento di Medicina Preventiva, Occupazionale e di Communità, Sezione di Igiene, Università di Pavia, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Roggi
authors.forename: C
authors.initials: C
authors.lastname: Minoia
authors.forename: G F
authors.initials: GF
authors.lastname: Sciarra
authors.forename: P
authors.initials: P
authors.lastname: Apostoli
authors.forename: L
authors.initials: L
authors.lastname: Maccarini
authors.forename: S
authors.initials: S
authors.lastname: Magnaghi
authors.forename: A
authors.initials: A
authors.lastname: Cenni
authors.forename: A
authors.initials: A
authors.lastname: Fonte
authors.forename: G F
authors.initials: GF
authors.lastname: Nidasio
authors.forename: G
authors.initials: G
authors.lastname: Micoli
mesh_terms: D000328:Adult; D000368:Aged; D000428:Alcohol Drinking; D015415:Biomarkers / Q000652:urine; D015992:Body Mass Index; D015331:Cohort Studies; D003404:Creatinine / Q000652:urine; D004032:Diet; D004781:Environmental Exposure; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009153:Mutagens / Q000032:analysis* / Q000378:metabolism; D011721:Pyrenes / Q000009:adverse effects* / Q000032:analysis* / Q000378:metabolism; D012016:Reference Values; D012044:Regression Analysis; D012907:Smoking; D014556:Urine / Q000737:chemistry*
chemical_list: D015415:Biomarkers; D009153:Mutagens; D011721:Pyrenes; C030984:pyrene; D003404:Creatinine; C033146:1-hydroxypyrene