Therapeutic, toxic, and lethal concentrations in human fluids of 90 drugs affecting the cardiovascular and hematopoietic systems.
BACKGROUND
Drugs affecting the cardiovascular and hematopoietic systems are frequently involved in poisoning. As a continuation of our previously published study about the concentrations of drugs of abuse, we have compiled published data about these drugs and subjected them to selection and unification on the basis of conservative criteria and our own experience.


RESULTS
A compilation of the concentrations of 90 drugs affecting heart, circulation, blood or hematopoietic organs, in whole blood, serum/plasma, and urine, corresponding to therapeutic, toxic or lethal concentrations is given. Although the interpretation of the concentrations is a complex and difficult problem, the presented table can be helpful in interpretation from the actual concentrations of this group of drugs encountered in clinical, toxicological and forensic cases.
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Instituto Nacional de Toxicología, Sevilla, Spain. kuhn@cica.es
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D002317:Cardiovascular Agents / Q000009:adverse effects / Q000097:blood* / Q000652:urine*; D002319:Cardiovascular System / Q000187:drug effects* / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D005554:Forensic Medicine; D006397:Hematinics / Q000009:adverse effects / Q000097:blood* / Q000652:urine*; D006413:Hematopoietic System / Q000187:drug effects* / Q000378:metabolism; D006801:Humans; D007928:Lethal Dose 50
D002317:Cardiovascular Agents; D006397:Hematinics