Leukemia inhibitory factor (LIF) mRNA-expressing neuronal subpopulations in adult rat basal forebrain.
We have previously found leukemia inhibitory factor (LIF) mRNA in neurons of the adult rat brain. To identify which neuronal subpopulations are expressing LIF transcripts, non-radioactive in situ hybridization was combined with immunocytochemistry for various neuronal markers. Studying the rat basal forebrain and cerebral cortex, we find LIF mRNA is expressed in both cholinergic and GABAergic neurons. These data suggest a role for LIF in the function of these mature neurons.
Lemke
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R
Paul Flechsig Institute for Brain Research, University of Leipzig, Medical Faculty, Germany.
Gadient
R A
RA
Patterson
P H
PH
Bigl
V
V
Schliebs
R
R
D000818:Animals; D005904:Glial Fibrillary Acidic Protein / Q000096:biosynthesis; D006131:Growth Inhibitors / Q000096:biosynthesis*; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D015850:Interleukin-6; D053605:Leukemia Inhibitory Factor; D008222:Lymphokines / Q000096:biosynthesis*; D009474:Neurons / Q000378:metabolism*; D010275:Parasympathetic Nervous System / Q000378:metabolism; D016548:Prosencephalon / Q000166:cytology / Q000378:metabolism*; D012333:RNA, Messenger / Q000096:biosynthesis*; D051381:Rats; D017208:Rats, Wistar; D005680:gamma-Aminobutyric Acid / Q000096:biosynthesis
D005904:Glial Fibrillary Acidic Protein; D006131:Growth Inhibitors; D015850:Interleukin-6; D053605:Leukemia Inhibitory Factor; D008222:Lymphokines; D012333:RNA, Messenger; D005680:gamma-Aminobutyric Acid