title: Plasma myosin and creatine kinase time-course after a concentric-eccentric field exercise.
abstract: The effect of a concentric (uphill run)-eccentric (downhill run) field exercise of 22.3 km long was examined in five healthy male volunteers to compare the time course of changes in plasma creatine kinase (CK) activity and beta myosin heavy chain (beta MHC) concentration observed during the recovery. CK and beta MHC were examined in blood sampled before exercise, immediately and 5 hours after exercise ceased. Screenings were conducted 1, 2, 3, 4, 5 and 7 days later. For every subject, the peak of plasma CK was transient and observed within the first 24 hours of recovery. In contrast to CK changes, plasma beta-MHC elevation was delayed and the peak, also transient, was observed the second or the third day after the exercise. The highly significant relationship between individual values of CK and beta MHC (P < 0.001) demonstrates that beta MHC could be used as a marker of skeletal muscle damage after acute exercise.
authors.affiliation: Unité de Bioénergétique et Environnement, Centre de Recherches du Service de Santé des Armées Emile Pardé, La Tronche, France.
authors.forename: B
authors.initials: B
authors.lastname: Melin
authors.forename: L
authors.initials: L
authors.lastname: Bourdon
authors.forename: C
authors.initials: C
authors.lastname: Jimenez
authors.forename: A
authors.initials: A
authors.lastname: Charpenet
authors.forename: O
authors.initials: O
authors.lastname: Bernard
mesh_terms: D000328:Adult; D003402:Creatine Kinase / Q000097:blood*; D015444:Exercise / Q000502:physiology*; D006801:Humans; D008297:Male; D018995:Myosin Heavy Chains / Q000097:blood*; D024501:Nonmuscle Myosin Type IIB; D013997:Time Factors
chemical_list: D003402:Creatine Kinase; D024501:Nonmuscle Myosin Type IIB; C103815:nonmuscle myosin type IIB heavy chain; D018995:Myosin Heavy Chains