title: [Favorable results of early 2nd-stage medication in rheumatoid arthritis].
abstract: OBJECTIVE
  To compare the effects of treatment with and without 'slow-acting antirheumatic drugs' (SAARDs) for patients with recent-onset rheumatoid arthritis (RA).
  
  
  METHODS
  Open randomized clinical trial.
  
  
  METHODS
  Outpatient clinics of six medical centers, the Netherlands.
  
  
  METHODS
  The study population consisted of 304 consecutive patients with recently diagnosed RA. A therapeutic strategy with delayed introduction of a SAARD was compared with a strategy comprising early start of SAARD treatment. Primary endpoints were functional disability, pain, joint score, erythrocyte sedimentation rate and progression of radiological abnormalities at 12 months.
  
  
  RESULTS
  Four of the five endpoints improved statistically significantly more in the early-SAARD group than in the non-SAARD group; radiological abnormalities progressed at an equal rate in the two groups. Adverse reactions remained at an acceptable level and were the same in the two groups.
  
  
  CONCLUSIONS
  Early introduction of a SAARD was more beneficial than a therapeutic strategy with delayed introduction of a SAARD for patients with recently diagnosed RA.
authors.affiliation: Academisch Ziekenhuis, afd. Reumatologie en Klinische Immunologie, Utrecht.
authors.forename: C H
authors.initials: CH
authors.lastname: van Jaarsveld
authors.forename: A
authors.initials: A
authors.lastname: van der Heide
mesh_terms: D000203:Activities of Daily Living; D000328:Adult; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D018501:Antirheumatic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D003692:Delayed-Action Preparations; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010146:Pain; D011446:Prospective Studies; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D018501:Antirheumatic Agents; D003692:Delayed-Action Preparations