Modulation of cutaneous nociceptor activity by electrical stimulation in the brain stem does not inhibit the nociceptive excitation of dorsal horn neurons.
In anesthetized cats, recordings were obtained from single lumbar dorsal horn neurons and from primary afferent fibers of the posterior tibial nerve excited by controlled noxious radiant heating of glabrous hindpaw skin. Electrical stimulation in four brain stem regions (periaqueductal gray and lateral reticular formation in the midbrain, raphe and reticular formation in the medulla) during noxious skin heating markedly reduced the nociceptive excitation of the dorsal horn neurons. In contrast, such brain stem stimulation had small and variable effects upon the noxious heat-evoked activity in the primary afferent fibers; both increases and decreases were observed. The brain stimulation also produced transient changes in blood pressure, suggesting that circulatory effects may underlie the mechanism of nociceptor modulation. It is concluded that brain stem stimulation can modulate cutaneous nociceptor activity, but that this modulatory effect on nociceptor inflow is too small and inconsistent to explain the marked descending inhibition of the nociceptive excitation of dorsal horn neurons.
Morton
C R
CR
Division of Neuroscience, John Curtin School of Medical Research, Australian National University, Canberra, Australia.
Siegel
J
J
Xiao
H M
HM
Zimmermann
M
M
D000200:Action Potentials / Q000502:physiology; D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D001933:Brain Stem / Q000502:physiology*; D002415:Cats; D004558:Electric Stimulation; D004594:Electrophysiology; D005260:Female; D006358:Hot Temperature; D009412:Nerve Fibers / Q000502:physiology; D009474:Neurons / Q000502:physiology*; D009475:Neurons, Afferent / Q000502:physiology; D009619:Nociceptors / Q000502:physiology*; D012867:Skin / Q000294:innervation*; D013116:Spinal Cord / Q000166:cytology / Q000502:physiology*; D013979:Tibial Nerve / Q000502:physiology