Reappraisal of bicarbonate secretion by the human oesophagus.
OBJECTIVE
Administration of omeprazole to healthy volunteers was recently reported to increase proximal duodenal mucosal bicarbonate secretion. As human oesophagus also secretes bicarbonate, the hypothesis was tested that omeprazole may stimulate oesophageal bicarbonate secretion and thus contribute to the therapeutic efficacy of the drug in gastro-oesophageal reflux disease.


METHODS
In nine healthy volunteers, oesophageal "steady state" perfusion of a 10 cm open segment of distal oesophagus was performed twice in random order. The volunteers were pretreated with either 60 mg/day omeprazole for three days and 80 mg intravenous omeprazole before perfusion or 600 mg/day ranitidine for three days and 50 mg/h intravenously during the perfusion. Saliva and samples of aspirate from the perfused oesophagus and stomach were collected and bicarbonate concentrations were measured.


RESULTS
The median rates (95% confidence intervals) of intrinsic oesophageal bicarbonate secretion, corrected for contaminating salivary and gastric bicarbonate, were 89 (33-150) and 121 (63-203) mumol/h/10 cm (p > 0.5) in omeprazole and ranitidine treated subjects respectively. Salivary and gastric bicarbonate contaminating the oesophagus accounted for 14% and 3%, respectively, of total oesophageal bicarbonate output.


CONCLUSIONS
Bicarbonate secretory capacity of the human oesophagus is less than previously assumed, and the clinical relevance of intrinsic oesophageal bicarbonate for mucosal defence may be overestimated. As omeprazole and ranitidine did not affect bicarbonate secretion differently there was no evidence that omeprazole acts on bicarbonate secretory cells in the oesophageal mucosa.
Mertz-Nielsen
A
A
Department of Medical Gastroenterology, Hvidovre Hospital, University of Copenhagen, Denmark.
Hillingsø
J
J
Bukhave
K
K
Rask-Madsen
J
J
D000328:Adult; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D001639:Bicarbonates / Q000032:analysis / Q000378:metabolism*; D004947:Esophagus / Q000187:drug effects* / Q000378:metabolism; D005260:Female; D005766:Gastrointestinal Contents / Q000737:chemistry; D006801:Humans; D008297:Male; D009853:Omeprazole / Q000494:pharmacology*; D010477:Perfusion; D011899:Ranitidine / Q000494:pharmacology; D012463:Saliva / Q000737:chemistry
D000897:Anti-Ulcer Agents; D001639:Bicarbonates; D011899:Ranitidine; D009853:Omeprazole