[A preclinical evaluation of the pharmacological activity of a mixed potassium and magnesium glutamate].
Mixed magnesium and potassium glutamates with different ion ratio are synthesized. The antiarrhythmic activity of the compounds obtained is studied on the models of strophantin, calcium chloride, aconitine arrhythmia, and arrhythmia after Harriss. It is found that magnesium and potassium glutamate of the composition KMg(HGlu)4.4H2O exhibits higher activity compared to glutamate of the composition KMg(HGlu)4.3H2O on the strophantin and calcium chloride arrhythmia models. The study performed on the strophantin and calcium chloride models as well as on the Harriss arrhythmia model showed that KMg(HGlu)4.4H2O is more effective as antiarrhythmic drug than asparkam and panangine but, at the same time, the effect of KMg(HGlu)4.4H2O within the aconitine model is somewhat less pronounced compared to panangine.
Berliand
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Krylov
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D000157:Aconitine; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000188:drug therapy / Q000209:etiology; D003327:Coronary Disease / Q000150:complications; D004195:Disease Models, Animal; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D005260:Female; D005971:Glutamates / Q000627:therapeutic use*; D018698:Glutamic Acid / Q000627:therapeutic use*; D008297:Male; D011189:Potassium Chloride; D011195:Potassium Magnesium Aspartate / Q000627:therapeutic use; D011817:Rabbits; D051381:Rats; D013328:Strophanthins
D000889:Anti-Arrhythmia Agents; D005971:Glutamates; D013328:Strophanthins; D018698:Glutamic Acid; D011189:Potassium Chloride; D011195:Potassium Magnesium Aspartate; C029082:strophanthin K; D000157:Aconitine