Bidirectional regulation of smooth muscle cell proliferation by IFN-gamma.
We studied the effects of interferon gamma (IFN-gamma), a T-cell lymphokine, on the proliferation and chemotaxis of vascular smooth muscle cells (SMC). Recombinant human IFN-gamma dose-dependently inhibited the proliferation of SMC cultured in the presence of 20% fetal calf-serum. It also inhibited PDGF-induced chemotaxis of SMC. Similar concentrations of IFN-gamma induced DNA-synthesis of SMC cultured in mitogen-depleted medium for 5 days. The inhibition and the stimulation of SMC proliferation were accompanied by concomitant decrease and increase in the number of PDGF receptors. Our study indicated that IFN-gamma is a bidirectional regulator of SMC proliferation.
Shimokado
K
K
National Cardiovascular Center Research Institute, Osaka, Japan.
Yokota
T
T
Kato
N
N
Kosaka
C
C
Sasaguri
T
T
Masuda
J
J
Ogata
J
J
Numano
F
F
D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D002633:Chemotaxis / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D006801:Humans; D007371:Interferon-gamma / Q000494:pharmacology*; D008934:Mitogens / Q000494:pharmacology*; D009131:Muscle, Smooth, Vascular / Q000166:cytology / Q000187:drug effects*; D011994:Recombinant Proteins; D014469:Umbilical Arteries / Q000166:cytology / Q000187:drug effects
D008934:Mitogens; D011994:Recombinant Proteins; D007371:Interferon-gamma