[The effect of Moradol (butorphanol tartrate) on immunity].
Two groups (with n = 5 in each group) were studied of essentially healthy volunteers by double-blind method. Those subjects in group 1 were administered placebo, those in group 2 received 0.1 mg/kg of moradole. In both groups, blood to be analysed was taken in fixed time intervals. An investigation designed to study immunological parameters involved correlation of results obtained before and after administration of moradole or placebo. Opioid agonists are endowed with marked immunity-inhibiting effect disappearing after the administration of naloxone. A hypothesis has been formed to the effect that those drug preparations endowed with agonist-antagonist activity toward opioid receptors fail to induce immunodepression, otherwise it is less pronounced than that of opioid agonists. The studies made allow a conclusion to be reached that administration of moradole is not associated with immunodepression.
Byshovets
S N
SN
Treshchinskiĭ
A I
AI
Blazhenko
I L
IL
D000328:Adult; D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000494:pharmacology*; D002077:Butorphanol / Q000008:administration & dosage / Q000494:pharmacology*; D004311:Double-Blind Method; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects*; D007262:Infusions, Intravenous; D009292:Narcotic Antagonists / Q000008:administration & dosage / Q000494:pharmacology*; D009294:Narcotics / Q000819:agonists*; D010919:Placebos; D012016:Reference Values; D013997:Time Factors
D000701:Analgesics, Opioid; D009292:Narcotic Antagonists; D009294:Narcotics; D010919:Placebos; D002077:Butorphanol