Cerebral blood flow and cerebrovascular response to acetazolamide in patients with chronic alcoholism.
Cerebral blood flow and cerebrovascular response to acetazolamide were studied in 12 patients with chronic alcoholism and 12 age matched healthy controls. Blood flows in the cerebral cortex, thalamus, and putamen were significantly lower in the chronic alcoholic group than in the healthy control group. The increase in blood flow caused by acetazolamide did not show any significant difference between the two groups. These findings suggest that the decreased cerebral blood flow in chronic alcoholism is due to decreased cerebral metabolism.
Oishi
M
M
Department of Neurology, Nihon University, School of Medicine, Nerima-ku, Tokyo, Japan.
Mochizuki
Y
Y
Takasu
T
T
D000086:Acetazolamide / Q000494:pharmacology*; D000437:Alcoholism / Q000175:diagnosis* / Q000378:metabolism / Q000503:physiopathology; D001921:Brain / Q000378:metabolism; D002540:Cerebral Cortex / Q000098:blood supply; D002560:Cerebrovascular Circulation / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011699:Putamen / Q000098:blood supply; D012039:Regional Blood Flow / Q000187:drug effects; D013788:Thalamus / Q000098:blood supply; D014057:Tomography, X-Ray Computed; D014980:Xenon Radioisotopes
D014980:Xenon Radioisotopes; D000086:Acetazolamide