title: [Instenon in the treatment of acute disorders of the cerebral circulation].
abstract: Effectiveness of Instenon (Alkaloid Pharm. Co.), the preparation, containing hexobendin, hydroxytheophyllin, etamivan was investigated in treatment of patients with acute cerebrovascular disorders. Instenon was applied in acute phase of ischemic stroke both in form of ampules and dragee as well as for intravenous injections too. Marked positive influence of Instenon was observed on motor, sensory, autonomic and psychic functions. Instenon in form of ampules had advantage compared to dragee form in terms of faster positive alterations onset. Application of Instenon in form of ampules was more effective in patients with disorders of consciousness while usage of drug in the form of dragee was more effective in patients with cerebrovascular disorders in vertebro-basilar system. The drug hadn't significant influence on systemic arterial pressure either after single injection or long-termed treatment; the mild hypotensive effect was observed after therapeutical session. The drug was well tolerated by patients in both forms and hadn't any side effects. There were no negative consequences of Instenon interaction with other preparations. The conclusion was made about possibility of application of Instenon for the treatment of ischemic stroke.
authors.forename: A V
authors.initials: AV
authors.lastname: Ignatenko
authors.forename: A B
authors.initials: AB
authors.lastname: Danilov
mesh_terms: D000208:Acute Disease; D001549:Benzamides / Q000627:therapeutic use*; D000697:Central Nervous System Stimulants / Q000627:therapeutic use*; D002561:Cerebrovascular Disorders / Q000188:drug therapy*; D004338:Drug Combinations; D004341:Drug Evaluation; D006592:Hexobendine / Q000627:therapeutic use*; D006801:Humans; D009460:Neurologic Examination; D012074:Remission Induction; D013806:Theophylline / Q000031:analogs & derivatives* / Q000627:therapeutic use; D013997:Time Factors
chemical_list: D001549:Benzamides; D000697:Central Nervous System Stimulants; D004338:Drug Combinations; C001453:Instenon; D006592:Hexobendine; D013806:Theophylline