[Isolation and receptor binding properties of alkaloids and lignans from Valeriana officialis L].
In addition to the known Valeriana-Meanalkaloid, four 7,9':7'9-Diepoxylignans were isolated from the roots of Valeriana officinalis L. They were tested in different radioreceptorassays at the 5-HT1A-, GABAA-, benzodiazepin and mu-opiate-receptor.
Bodesheim
U
U
Institut für Pharmazeutische Biologie, Philipps-Universität Marburg/Lahn, Germany.
Hölzl
J
J
D000470:Alkaloids / Q000302:isolation & purification / Q000378:metabolism* / Q000494:pharmacology; D000818:Animals; D001921:Brain / Q000378:metabolism; D066298:In Vitro Techniques; D017705:Lignans / Q000302:isolation & purification / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D010946:Plants, Medicinal / Q000737:chemistry*; D011869:Radioligand Assay; D051381:Rats; D017208:Rats, Wistar; D011955:Receptors, Drug / Q000378:metabolism*; D011963:Receptors, GABA-A / Q000187:drug effects / Q000378:metabolism; D011957:Receptors, Opioid / Q000187:drug effects / Q000378:metabolism; D011985:Receptors, Serotonin / Q000378:metabolism
D000470:Alkaloids; D017705:Lignans; D011955:Receptors, Drug; D011963:Receptors, GABA-A; D011957:Receptors, Opioid; D011985:Receptors, Serotonin