[The effect of ligustrazine and 764-3 on type I and type III collagen mRNA expression in fibroblasts].
The effect of ligustrazine and 764-3 on type I and type II collagen mRNA expression in cultured fibroblasts was studied. The results showed that ligustrazine at a final concentration of 30 micrograms/ml for 24 hours could inhibit type I and type II collagen mRNA expression, 764-3 at a final concentration of 15 micrograms/ml for 24 hours could stimulate type I collagen mRNA expression, but exerted no effect on type II collagen expression. The possible mechanism of 764-3 action was discussed.
Yan
Y
Y
Institute of Basic Medical Sciences, CAMS and PUMC, Beijing.
Chen
X
X
Wu
K
K
Li
H
H
D002478:Cells, Cultured; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005343:Fibrinolytic Agents / Q000494:pharmacology*; D005347:Fibroblasts / Q000378:metabolism; D006801:Humans; D008168:Lung / Q000166:cytology*; D011347:Procollagen / Q000235:genetics*; D011719:Pyrazines / Q000494:pharmacology*; D012333:RNA, Messenger / Q000378:metabolism*
D004365:Drugs, Chinese Herbal; D005343:Fibrinolytic Agents; C079053:IH 764-3; D011347:Procollagen; D011719:Pyrazines; D012333:RNA, Messenger; C017953:tetramethylpyrazine