title: Mutation rates as adaptations.
abstract: In order to better understand life, it is helpful to look beyond the envelop of life as we know it. A simple model of coevolution was implemented with the addition of a gene for the mutation rate of the individual. This allowed the mutation rate itself to evolve in a lineage. The model shows that when the individuals interact in a sort of zero-sum game, the lineages maintain relatively high mutation rates. However, when individuals engage in interactions that have greater consequences for one individual in the interaction than the other, lineages tend to evolve relatively low mutation rates. This model suggests that one possible cause for differential mutation rates across genes may be the coevolutionary pressure of the various forms of interactions with other genes.
authors.affiliation: Massachusetts Institute of Technology, Cambridge 02139, USA. cmaley@ai.mit.edu
authors.forename: C
authors.initials: C
authors.lastname: Maley
mesh_terms: D000222:Adaptation, Physiological / Q000235:genetics*; D000818:Animals; D005075:Biological Evolution; D003198:Computer Simulation; D005809:Genes, Regulator; D008957:Models, Genetic; D009154:Mutation