Plasma endothelin-1 levels during transient acute myocardial ischaemia in men: effects of coronary revascularization.
The endothelium-derived peptide endothelin-1 (ET-1) was evaluated in 14 male patients [mean age 52.74 years (SEM 1.10)] affected by coronary artery disease during a bicycle electrocardiographic stress test and dipyridamole echocardiogram. Both tests were performed before and after coronary revascularization. Fourteen healthy male subjects served as controls [mean age 53.21 years (SEM 1.63)]. Baseline plasma endothelin-1 levels were higher (P < 0.0001) in ischaemic patients [1.81 pg mL-1 (0.15, n = 14)] than in control subjects [0.61 pg mL-1 (0.03, n = 14)], but did not increase with exercise in both groups. Similar results were obtained with dipyridamole infusion. Endothelin-1 levels significantly decreased after coronary revascularization [before: mean 1.81 pg mL-1 (SEM 0.15, n = 14); after: mean 1.16 pg mL-1 (SEM 0.11), P < 0.002], without changes in the peptide response to both tests. In conclusion, elevated plasma endothelin-1 concentrations were found in patients with stable angina compared with non-ischaemic subjects. No changes were observed during exercise or dipyridamole infusion in both groups. Coronary revascularization was followed by a significant decrease in plasma endothelin-1 levels.
Ferri
C
C
University La Sapienza, Institute of I Clinica Medica, Andrea Cesalpino Foundation, Rome, Italy.
De Marzio
P
P
Desideri
G
G
Baldoncini
R
R
Bellini
C
C
Morelli
S
S
Santucci
A
A
D000328:Adult; D000787:Angina Pectoris / Q000097:blood / Q000503:physiopathology / Q000601:surgery; D016022:Case-Control Studies; D004176:Dipyridamole; D004452:Echocardiography; D019332:Endothelin-1 / Q000097:blood*; D005080:Exercise Test; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000097:blood* / Q000503:physiopathology / Q000601:surgery*; D009204:Myocardial Revascularization
D019332:Endothelin-1; D004176:Dipyridamole