title: Embryotoxicity/teratogenicity study with isomaltulose (Palatinose) in rats.
abstract: The embryotoxicity/teratogenicity of the natural sweetener isomaltulose (Palatinose) was studied in Wistar rats. Groups of 24 mated females were fed diets containing isomaltulose at levels of 0, 2.5, 5 and 10% from day 0 to day 21 of pregnancy. The dams were killed on day 21 of pregnancy. No maternal toxicity occurred and no effects on reproductive performance, nor on embryonic or foetal development, including visceral and skeletal examination, were seen in any of the groups fed isomaltulose. The dietary level of 10% isomaltulose was equivalent to about 7 g/kg body weight/day.
authors.affiliation: TNO Nutrition and Food Research Institute, Zeist, The Netherlands.
authors.forename: B A
authors.initials: BA
authors.lastname: Lina
authors.forename: A E
authors.initials: AE
authors.lastname: Smits-Van Prooije
authors.forename: D H
authors.initials: DH
authors.lastname: Waalkens-Berendsen
mesh_terms: D000014:Abnormalities, Drug-Induced; D000818:Animals; D001842:Bone and Bones / Q000002:abnormalities / Q000187:drug effects; D004622:Embryo, Mammalian / Q000187:drug effects*; D005314:Embryonic and Fetal Development / Q000187:drug effects*; D005260:Female; D005333:Fetus / Q000002:abnormalities / Q000187:drug effects; D007534:Isomaltose / Q000031:analogs & derivatives* / Q000633:toxicity; D008297:Male; D011247:Pregnancy; D051381:Rats; D012098:Reproduction / Q000187:drug effects; D013723:Teratogens / Q000633:toxicity*; D014781:Viscera / Q000002:abnormalities / Q000187:drug effects
chemical_list: D013723:Teratogens; D007534:Isomaltose; C008189:isomaltulose