Co-receptors of B lymphocytes.
The past year has seen advances in our understanding of accessory membrane proteins that modulate the B cell response to antigen-receptor stimulation. The generation of complement receptor deficient mice has reinforced our appreciation of the importance of complement receptors in the B cell response to antigen. The association of inositol polyphosphate 5-phosphatase with FcgammaRIIB suggests another mechanism, in addition to recruitment of the phosphotyrosine phosphatase SHP-1, by which secreted immunoglobulin can limit further response to antigen. The in vivo function of CD22 in regulating the threshold of antigen-receptor signalling has been shown using CD22-deficient mice. Lastly, B cell receptor signalling in the B-1 subset of B lymphocytes has been demonstrated to be negatively regulated by CD5.
O'Rourke
L
L
Wellcome Trust Immunology Unit, University of Cambridge School of Clinical Medicine, Cambridge, CB2 2SP, UK.
Tooze
R
R
Fearon
D T
DT
D000818:Animals; D015703:Antigens, CD / Q000276:immunology; D018941:Antigens, CD19 / Q000276:immunology; D000944:Antigens, Differentiation, B-Lymphocyte / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology*; D015815:Cell Adhesion Molecules; D006801:Humans; D037102:Lectins; D008213:Lymphocyte Activation / Q000276:immunology; D051379:Mice; D011961:Receptors, Fc / Q000276:immunology; D011971:Receptors, Immunologic / Q000276:immunology*; D051918:Sialic Acid Binding Ig-like Lectin 2; D015398:Signal Transduction / Q000276:immunology*
D015703:Antigens, CD; D018941:Antigens, CD19; D000944:Antigens, Differentiation, B-Lymphocyte; C497867:CD22 protein, human; C497868:Cd22 protein, mouse; D015815:Cell Adhesion Molecules; D037102:Lectins; D011961:Receptors, Fc; D011971:Receptors, Immunologic; D051918:Sialic Acid Binding Ig-like Lectin 2