title: [Dose-response relationship of trans-scleral contact cyclophotocoagulation].
abstract: OBJECTIVE
  In recent years, transscleral contact-cyclophotocoagulation has increasingly been used for the treatment of therapy-refractive glaucomas. The dose-effect correlation varies according to different authors. In this retrospective study, we tried to determine whether there is a dose-effect correlation of transscleral contact-cyclophotocoagulation.
  
  
  METHODS
  Following diagnosis, 124 eyes of 113 patients (age range 49.9 +/- 26.5 years) were included in the study. The laser parameters used were reviewed along with the intraocular pressure (IOP) before treatment, after treatment and during the follow-up (mean 6 months).
  
  
  RESULTS
  The IOP of 45.2% (56) of 124 eyes was < 22 mmHg. In 25.8% (32 eyes) a retreatment was necessary. No correlation between energy and decrease of IOP was found (Prs = 0.08 nonsignificant, Spearmann rank correlation). The IOP was reduced from 35.8 +/- 10.5 mmHg preoperatively to 26.3 +/- 10.5 mmHg at the end of follow-up (P approximately 0, Wilcoxon test). Therapy could be reduced by up to three antiglaucomatous drugs in therapy-refractive eyes.
  
  
  CONCLUSIONS
  These data show that a decrease of about 10 mmHg of the IOP is possible using transscleral contact-cyclophotocoagulation. In therapy-refractive eyes, fewer drugs were needed to reach an IOP < 22 mmHg. Regardless of the diagnosis, a dose-effect correlation between the decrease of IOP and laser energy was not found.
authors.affiliation: Universitäts-Augenklinik Köln.
authors.forename: R
authors.initials: R
authors.lastname: Krott
authors.forename: M
authors.initials: M
authors.lastname: Diestelhost
authors.forename: M
authors.initials: M
authors.lastname: Zollweg
authors.forename: G K
authors.initials: GK
authors.lastname: Krieglstein
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D005901:Glaucoma / Q000503:physiopathology / Q000601:surgery*; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology*; D008028:Light Coagulation / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000503:physiopathology*; D012599:Sclerostomy / Q000379:methods*; D016896:Treatment Outcome