Intravenous anaesthetics: some cellular sites of action.
Intravenous anaesthetics have diverse effects on neurones within the central nervous system. Only those that occur at clinical concentrations are likely to be relevant. The dominant effect of many agents is the potentiation of the inhibitory neurotransmitter gamma amino butyric acid (GABA) by various mechanisms while inhibiting the effects of excitatory transmitters seems to be less dominant, except for ketamine.
Dzoljic
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London Health Sciences Centre, Ontario, Canada.
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AW
D018685:Anesthetics, Inhalation / Q000494:pharmacology; D018686:Anesthetics, Intravenous / Q000494:pharmacology*; D000818:Animals; D006801:Humans; D007473:Ion Channels / Q000187:drug effects; D011941:Receptors, Adrenergic / Q000187:drug effects; D018079:Receptors, GABA / Q000187:drug effects; D017470:Receptors, Glutamate / Q000187:drug effects
D018685:Anesthetics, Inhalation; D018686:Anesthetics, Intravenous; D007473:Ion Channels; D011941:Receptors, Adrenergic; D018079:Receptors, GABA; D017470:Receptors, Glutamate