Longevity treatment with (-)deprenyl in female rats: effect on copulatory activity and lifespan.
Six months old ovariectomized female rats (n = 9) were treated with (-)deprenyl in a dose of 0.25 mg/kg s.c. three times a week, and (n = 9) with physiologic saline (0.1 ml/100 g) till decay. It was found that control females (n = 9) decayed within the age of fifteen months while the members of the (-)deprenyl treated group were all alive at that age. Moreover three (-)deprenyl treated female rats reached 36 months of age. Sexual activity was quite absent in both groups. The data suggests that (-)deprenyl extended the lifespan of female rats only in total absence of gonadal hormones and sexual activity.
Dalló
J
J
Department of Pharmacology, Semmelweis University of Medicine, Budapest, Hungary.
Köles
L
L
D000818:Animals; D003307:Copulation / Q000187:drug effects*; D005260:Female; D008136:Longevity / Q000187:drug effects*; D008297:Male; D010052:Ovariectomy; D051381:Rats; D017208:Rats, Wistar; D012642:Selegiline / Q000494:pharmacology*; D012727:Sex Characteristics; D012726:Sexual Behavior, Animal / Q000187:drug effects*; D013237:Stereoisomerism
D012642:Selegiline