title: Twenty two weeks of transdermal estradiol increases sex hormone-binding globulin in surgical menopausal women.
abstract: OBJECTIVE
  To compare the effects of continuous noncombined transdermal estradiol versus oral conjugated estrogen on serum sex hormone-binding globulin (SHBG) levels prior to and during the 10th and 22nd weeks of therapy in patients with surgical menopause.
  
  
  METHODS
  Open, comparative trial. Patients were consecutively assigned to three groups: group 1 (n = 18) received continuous transdermal estradiol (0.050 mg/day), group 2 (n = 18) continuous oral conjugated estrogens (0.625 mg/day), whereas group 3 (n = 15) received no treatment. Serum SHBG levels were determined before treatment and after 10 and 22 weeks of treatment.
  
  
  RESULTS
  Serum SHBG increased significantly with oral conjugated estrogens at 10 (p < 0.01) and 22 weeks (p < 0.01) compared with baseline. With transdermal estrogens there was a much smaller increase of SHBG. At 22 weeks, this increase was significant compared with baseline (p < 0.05), but not compared with the control group (p > 0.05).
  
  
  CONCLUSIONS
  Transdermal estrogen has no effect on SHBG, whereas oral conjugated estrogens causes considerable increase.
authors.affiliation: Department of Obstetrics and Gynecology, Erciyes University School of Medicine, Kayseri, Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Başbuğ
authors.forename: E
authors.initials: E
authors.lastname: Aygen
authors.forename: M
authors.initials: M
authors.lastname: Tayyar
authors.forename: S
authors.initials: S
authors.lastname: Muhtaroğlu
authors.forename: I
authors.initials: I
authors.lastname: Demir
authors.forename: S
authors.initials: S
authors.lastname: Okten
mesh_terms: D000279:Administration, Cutaneous; D000284:Administration, Oral; D000368:Aged; D004334:Drug Administration Schedule; D004958:Estradiol / Q000627:therapeutic use*; D015914:Estrogen Replacement Therapy / Q000379:methods*; D005260:Female; D006801:Humans; D007044:Hysterectomy; D008594:Menopause, Premature; D008875:Middle Aged; D012738:Sex Hormone-Binding Globulin / Q000378:metabolism*
chemical_list: D012738:Sex Hormone-Binding Globulin; D004958:Estradiol