[Interactions of the most frequently used drugs in the treatment of angina pectoris].
It seems that knowledge and evaluation of drug-interactions with organic nitrates, beta-blockers and calcium-channel blockers are of great importance in relation to patients with chronic diseases, who usually take more than one drug, which is in conjunction with the effect of their ageing. Organic nitrates are safe and the most important drug-group in angina pectoris therapy. Beta-adrenoreceptor blocking agents and calcium-channel blockers are involved in interactions with many different drugs (twenty interactions), but only three interactions are evaluated as interactions of high clinical significance (adrenaline, cimetidine and anti-thyroid agents with beta-blockers, and anti-arrhythmic agents, beta-blockers and cyclosporin with calcium-channel blockers), while the others are of moderate or minimal significance. The most desired interactions of these drugs can be avoided: adjustment of dosage, avoidance of fixed-combination, use of adequate form of drug, or alternative drug and, if necessary, elimination of one drug from therapy. Knowledge of these drug-interactions is important for physician's routine practice either in primary health-care or in hospital conditions.
Miljković
M
M
Pharmacist's Institution, Kraljevo.
Tanasijević
G
G
D000787:Angina Pectoris / Q000188:drug therapy*; D004347:Drug Interactions; D006801:Humans