Losartan does not influence the blood platelet aggregation in normotensive rats.
Platelet aggregation was studied in PRP upon stimulation with ADP and collagen in normotensive rats treated with losartan (10 mg/kg). The acute and subchronic (5 days) losartan administration did not change the aggregating response of rat platelets. Similarly, in vitro study aggregation of platelets remained unaltered following incubation with losartan and its active metabolite EXP3174. In this study we presented the lack of influence of losartan and its main metabolite on rat platelet aggregation in normotensive rats.
Chabielska
E
E
Department of Pharmacodynamics, Medical School, Białystok, Poland.
Pawlak
R
R
Buczko
W
W
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000804:Angiotensin II / Q000494:pharmacology; D057911:Angiotensin Receptor Antagonists; D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001713:Biphenyl Compounds / Q000494:pharmacology*; D001794:Blood Pressure; D003094:Collagen / Q000494:pharmacology; D007093:Imidazoles / Q000494:pharmacology*; D019808:Losartan; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012016:Reference Values; D013777:Tetrazoles / Q000494:pharmacology*
D057911:Angiotensin Receptor Antagonists; D000959:Antihypertensive Agents; D001713:Biphenyl Compounds; D007093:Imidazoles; D010975:Platelet Aggregation Inhibitors; D013777:Tetrazoles; D000804:Angiotensin II; D000244:Adenosine Diphosphate; D003094:Collagen; D019808:Losartan