[A chronobiological study of the function of the epithelial proliferative system of the murine esophagus after its infection with typhoid and the use of lomefloxacin].
The rhythmical character of the function of the proliferative system of the oesophagus epithelium of mice changed after infection by Salmonella typhi and after injection of lomefloxacin to intact and infected mice. The degree of the changes depended on the exposure time. The proliferative system of the oesophagus epithelium was more resistant to the infection in the night-time than the day-time and equally resistant to the effect of lomefloxacin in both the day-time and the night-time. The proliferative system of the oesophagus epithelium of the infected mice exposed to lomefloxacin in the day-time proved to be in a noncompensated state and in the night-time it proved to be in the hyperfunctional state.
Romanov
Iu A
IuA
Irikov
O A
OA
D000818:Animals; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D002455:Cell Division / Q000187:drug effects; D002909:Chronobiology Phenomena / Q000187:drug effects*; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D004848:Epithelium / Q000187:drug effects / Q000473:pathology; D004935:Esophageal Diseases / Q000188:drug therapy* / Q000473:pathology; D004947:Esophagus / Q000187:drug effects* / Q000473:pathology; D024841:Fluoroquinolones; D008297:Male; D051379:Mice; D008940:Mitotic Index / Q000187:drug effects; D015363:Quinolones / Q000627:therapeutic use*; D013997:Time Factors; D014435:Typhoid Fever / Q000188:drug therapy* / Q000473:pathology
D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D015363:Quinolones; C053091:lomefloxacin