[Fertilization in vitro and embryo transfer by combined long-acting gonadotropin releasing hormone agonist and gonadotropin for superovulation in patients with refractory polycystic ovary syndrome].
OBJECTIVE
To investigate the efficacy of the treatment for polycystic ovary syndrome (PCOS) patients by combined long acting gonadotropin-releasing hormone agonist (GnRHa) and gonadotropin.


METHODS
Nineteen women with PCOS who had failed to conceive on treatment with conventional fertilization in vitro-embryo transfer (IVF-ET) protocol underwent 26 cycles of IVF-ET by combined long-acting and gonadotropin stimulation. A self-control group consisted of 19 PCOS women who had received 19 treatment cycles with conventional IVF-ET stimulation protocol more than 6 months previously.


RESULTS
A comparison of these two groups showed that treatment with combined long-acting GnRHa and gonadotropin improved the in vitro fertility rate (76.2%) and pregnancy rate (38.5%).


CONCLUSIONS
Patients with refractory PCOS should be referred for IVF-ET, using long-acting GnRHa before gonadotropin as the stimulation protocol.
Li
R
R
First Affiliated Hospital of Sun Yet-Sen University of Medical Sciences, Guangzhou.
Zhuang
G
G
Zhou
C
C
D000328:Adult; D003692:Delayed-Action Preparations; D004359:Drug Therapy, Combination; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro; D007987:Gonadotropin-Releasing Hormone / Q000819:agonists* / Q000627:therapeutic use; D006062:Gonadotropins / Q000627:therapeutic use*; D006801:Humans; D011085:Polycystic Ovary Syndrome / Q000188:drug therapy*; D013480:Superovulation; D017329:Triptorelin Pamoate / Q000627:therapeutic use*
D003692:Delayed-Action Preparations; D006062:Gonadotropins; D017329:Triptorelin Pamoate; D007987:Gonadotropin-Releasing Hormone