Cortical 5-HT-CCK interactions and anxiety-related behaviour of guinea-pigs: a microdialysis study.
Serotonin (5-HT) and cholecystokinin (CCK) are involved in the development of anxiety. There are only few data suggesting interactions between CCK and 5-HT under aversive conditions. In our study the cholecystokinin tetrapeptide (CCK-4) (10 microg/kg) induced 'anxious' behaviour and potentiated the increase of 5-HT release on the elevated plus maze (X-maze). The 'anxiolytic' 5-HT1A agonist 8-hydroxy-2-(di-n-propyl amino) tetralin (8-OH-DPAT; 0.3 mg/kg) reduced basal 5-HT and the increase in 5-HT release on the X-maze. 8-OH-DPAT given simultaneously with CCK-4, blocked the effects of CCK-4. The results demonstrate an interaction between CCK and 5-HT1A mechanisms via the influence on cortical 5-HT release.
Rex
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Institute of Pharmacology and Toxicology, Medical Faculty of the Humboldt University at Berlin, Germany.
Marsden
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CA
Fink
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D017371:8-Hydroxy-2-(di-n-propylamino)tetralin / Q000494:pharmacology; D000818:Animals; D001007:Anxiety / Q000188:drug therapy / Q000378:metabolism* / Q000503:physiopathology; D001522:Behavior, Animal / Q000187:drug effects; D002540:Cerebral Cortex / Q000737:chemistry / Q000187:drug effects / Q000502:physiology; D005260:Female; D006168:Guinea Pigs; D018782:Maze Learning / Q000187:drug effects; D017551:Microdialysis; D043887:Receptor, Cholecystokinin B; D011949:Receptors, Cholecystokinin / Q000819:agonists / Q000037:antagonists & inhibitors; D012701:Serotonin / Q000378:metabolism*; D017366:Serotonin Receptor Agonists / Q000494:pharmacology; D013758:Tetragastrin / Q000378:metabolism / Q000494:pharmacology*
D043887:Receptor, Cholecystokinin B; D011949:Receptors, Cholecystokinin; D017366:Serotonin Receptor Agonists; D013758:Tetragastrin; D012701:Serotonin; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin