Cytogenetic findings in 303 Mexican patients with de novo acute myeloblastic leukemia.
In this report we show the chromosomal changes seen in a group of 303 Mexican patients with de novo Acute Myeloblastic Leukemia (AML). Two hundred forty-two patients were diagnosed and treated at two hospitals affiliated with the Instituto Mexicano del Seguro Social (IMSS). These are the Centro Medico Nacional Siglo XXI and Centro Medico La Raza Hospitals; the remaining 61 patients were diagnosed and treated at the Hospital General de Mexico (HGM). Clonal abnormalities were detected in 75.6% of the patients; this result agrees with what has been reported in other large series of AML studies. The incidence of changes per hospital was similar in patients from the IMSS hospitals (72-75%), while an increase was seen in patients from the HGM (85.2%). The chromosomal changes seen in this study in order of frequency were: t(15;17)[18.8%], t(9;22)[9.2%], miscellaneous chromosomal changes (mainly rearrangements of chromosomes 1,2,3,12y17)[8.2%], abnormalities of 16q22 [7.3%], t(8;21)[6.3%], -7/del(7q)[5.6%], t(6;9)[5.3%], and abnormalities of 11q23 [4.6%]. We reported an increase in the incidence of certain types of chromosomal changes seen in cases of AML, in comparison with reports from other countries. These differences could be due to methodological variations, although ethnic, socioeconomic and nutritional differences must not be disregarded. We support this finding when comparing distribution of changes in the population of patients seen in the IMSS hospitals with those from the HGM; the main difference lies in the socioeconomic level.
Arana-Trejo
R M
RM
Departamento de Genética, Hospital General de México SSa, México, D.F.
Gómez-Morales
E
E
Rubio-Borja
M E
ME
Kassack-Ipiña
J J
JJ
Cervantes-Peredo
A
A
Guerrero-Rivera
S
S
González-Llaven
J
J
Gutiérrez-Romero
M
M
Pizzuto-Chávez
J
J
Kofman-Alfaro
S
S
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D002869:Chromosome Aberrations; D002872:Chromosome Deletion; D002884:Chromosomes, Human, Pair 15 / Q000648:ultrastructure; D002886:Chromosomes, Human, Pair 17 / Q000648:ultrastructure; D002999:Clone Cells / Q000648:ultrastructure; D005260:Female; D006769:Hospitals, General; D006779:Hospitals, Public; D006801:Humans; D015994:Incidence; D007951:Leukemia, Myeloid / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology; D008297:Male; D008800:Mexico / Q000453:epidemiology; D008875:Middle Aged; D014411:Neoplastic Stem Cells / Q000648:ultrastructure; D010677:Philadelphia Chromosome; D012943:Social Security; D012959:Socioeconomic Factors; D014178:Translocation, Genetic