title: Vascular remodeling and mineralocorticoids.
abstract: Circulating mineralocorticoid hormones are so named because of their important homeostatic properties that regulate salt and water balance via their action on epithelial cells. A broader range of functions in nonclassic target cellular sites has been proposed for these steroids and includes their contribution to wound healing following injury. A chronic, inappropriate (relative to intravascular volume and dietary sodium intake) elevation of these circulating hormones evokes a wound healing response in the absence of tissue injury--a wound healing response gone awry. The adverse remodeling of vascularized tissues seen in association with chronic mineralocorticoid excess is the focus of this review.
authors.affiliation: Department of Internal Medicine, University of Missouri Health Sciences Center, Columbia, USA.
authors.forename: K T
authors.initials: KT
authors.lastname: Weber
authors.forename: Y
authors.initials: Y
authors.lastname: Sun
authors.forename: S E
authors.initials: SE
authors.lastname: Campbell
authors.forename: S H
authors.initials: SH
authors.lastname: Slight
authors.forename: V K
authors.initials: VK
authors.lastname: Ganjam
mesh_terms: D000450:Aldosterone / Q000009:adverse effects* / Q000378:metabolism; D000818:Animals; D005347:Fibroblasts / Q000187:drug effects / Q000378:metabolism; D006706:Homeostasis; D006801:Humans; D008901:Mineralocorticoids / Q000009:adverse effects / Q000502:physiology*; D009131:Muscle, Smooth, Vascular / Q000187:drug effects* / Q000473:pathology*; D018161:Receptors, Mineralocorticoid / Q000187:drug effects
chemical_list: D008901:Mineralocorticoids; D018161:Receptors, Mineralocorticoid; D000450:Aldosterone