title: [The effect of complete fasting on the structural-functional organization of the white pulp of the spleen].
abstract: The work presents the results of morphologic, electron microscopic and morphometric assessment of the liver in white mongrel rats in the dynamics of complete long fasting. The investigations reveal that 7 days complete fasting in animals is accompanied by a certain dynamics of structural-functional reconstruction in various zones of splenic white pulp. The periarterial area shows microlymphocytes number decrease (T-dependent zone). However, B-dependent area of splenic white pulp experiences more significant reducing lymphocytes. Via electron microscopic observation pit-cells ultrastructure (the tissue form of large containing granules lymphocytes possessing a natural killing activity) has been ascertained. It is of note that in the dynamics of complete fasting there occurs remarkable increasing a relative pit-cells quantity, these pit-cells containing osmophilic macrogranules, proving their sharp functional activity rise. Complete long fasting demonstrates sufficient immunosuppressive effect with simultaneous enhancing nonspecific resistance of the organism due to a greater amount of natural killers and ascending their functional activity.
authors.forename: O Ie
authors.initials: OIe
authors.lastname: Kuziv
mesh_terms: D000222:Adaptation, Physiological; D000704:Analysis of Variance; D000818:Animals; D005215:Fasting / Q000502:physiology*; D007113:Immunity, Innate / Q000502:physiology; D008297:Male; D008854:Microscopy, Electron; D051381:Rats; D013154:Spleen / Q000502:physiology* / Q000648:ultrastructure; D013997:Time Factors