title: The role of reduced ear size in the prenatal detection of chromosomal abnormalities.
abstract: A prospective ultrasound study was performed between 18 and 38 weeks' gestation on 29 fetuses in a high-risk population, defined by the presence of structural anomalies, in order to investigate the usefulness of fetal ear measurements in the prenatal prediction of chromosomal abnormality. The prevalence of abnormal chromosomes was 34 per cent. The sensitivity (SE), specificity (SC), positive predictive values (PPV), and negative predictive values (NPV) of ear length for the detection of chromosomal abnormality were 80, 84.2, 72.7 and 88.9 per cent. The SE, SC, PPV, and NPV of ear width were 40, 94.7, 80 and 75 per cent. Fetal ear measurements may be a useful adjunct to the various ultrasound parameters in the prenatal detection of chromosome abnormality in a high-risk population of fetuses with structural anomaly(ies).
authors.affiliation: Department of Obstetrics and Gynaecology, Ottawa General Hospital, Canada.
authors.forename: T
authors.initials: T
authors.lastname: Shimizu
authors.forename: L
authors.initials: L
authors.lastname: Salvador
authors.forename: R
authors.initials: R
authors.lastname: Hughes-Benzie
authors.forename: L
authors.initials: L
authors.lastname: Dawson
authors.forename: C
authors.initials: C
authors.lastname: Nimrod
authors.forename: J
authors.initials: J
authors.lastname: Allanson
mesh_terms: D000293:Adolescent; D000328:Adult; D002869:Chromosome Aberrations / Q000175:diagnosis*; D025063:Chromosome Disorders; D004431:Ear, External / Q000196:embryology*; D005260:Female; D006801:Humans; D007621:Karyotyping; D016014:Linear Models; D011237:Predictive Value of Tests; D011247:Pregnancy; D011296:Prenatal Diagnosis / Q000379:methods*; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D016216:Ultrasonography, Prenatal