Effect of sleep deprivation on the growth hormone response to the alpha-3 adrenergic receptor agonist, clonidine, in normal subjects.
One night's sleep deprivation (SD) increased the growth hormone (GH) response to clonidine (20 ug/kg i.v.) in 11 normal men ( p < 0.005). This finding may indicate that SD enhances alpha-2 adrenergic receptor function or that the GH response to GH releasing factor in increased by SD.
Lal
S
S
Douglas Hospital Research Centre, Verdum Quebec, Canada.
Thavundayil
J X
JX
Krishnan
B
B
Nair
N P
NP
Schwartz
G
G
Kiely
M E
ME
Guyda
H
H
D058647:Adrenergic alpha-2 Receptor Agonists; D000316:Adrenergic alpha-Agonists / Q000494:pharmacology*; D000328:Adult; D019540:Area Under Curve; D003000:Clonidine / Q000494:pharmacology*; D013006:Growth Hormone / Q000097:blood*; D006801:Humans; D008297:Male; D009638:Norepinephrine / Q000502:physiology; D012892:Sleep Deprivation / Q000503:physiopathology*
D058647:Adrenergic alpha-2 Receptor Agonists; D000316:Adrenergic alpha-Agonists; D013006:Growth Hormone; D003000:Clonidine; D009638:Norepinephrine