Nonpeptide angiotensin II receptor antagonists: synthesis and biological activity of 1H-imidazo and 1H-[1,2,3]-triazolo fused derivatives.
A series of 1H-Imidazo and 1H-[1,2,3]-Triazolo fused derivatives have been obtained and tested as non peptide AII receptor antagonists. Modification of the classical biphenyl moiety to a 4-arylthienyl fragment afforded interesting activities.
Delgado
F
F
Departamento de Química Orgánica, Universidad de Alcalá, Madrid, Spain.
Pastor
J
J
García-Navío
J L
JL
Vaquero
J J
JJ
Alvarez-Builla
J
J
Sunkel
C
C
de Casa-Juana
M F
MF
Priego
J G
JG
Santos
L R
LR
Statkow
P R
PR
Straumann
D
D
D057911:Angiotensin Receptor Antagonists; D000818:Animals; D006168:Guinea Pigs; D007093:Imidazoles / Q000737:chemistry / Q000494:pharmacology*; D066298:In Vitro Techniques; D015394:Molecular Structure; D011817:Rabbits; D011945:Receptors, Angiotensin / Q000737:chemistry; D013329:Structure-Activity Relationship; D014230:Triazoles / Q000737:chemistry / Q000494:pharmacology*
D057911:Angiotensin Receptor Antagonists; D007093:Imidazoles; D011945:Receptors, Angiotensin; D014230:Triazoles