[Combined activity of meliacin and foscarnet against different strains of herpes simplex virus type 1 using a three-dimensional model].
We evaluated the in vitro antiviral activity of meliacin combined with foscarnet on the herpes simplex type 1 (HSV-1) strains F and B2006 (tk-) replication. The effective concentrations for 50% inhibition of HSV-1 (F) were 12.5 micrograms/ml for meliacin and 15.7 micrograms/ml for foscarnet, while for HSV-1 (B2006) were 3.1 micrograms/ml and 126 micrograms/ml, respectively. The data were analyzed for quantitation of synergism, additivity, and antagonism of multiple drug effect by the three-dimensional model. Some of the meliacin -foscarnet combinations synergistically inhibited HSV-1 (F) and HSV-1 (B2006) replication in vitro at concentrations that did not reduce cellular viability.
Barquero
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Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Argentina.
Villamil
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SM
D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D002522:Chlorocebus aethiops; D004352:Drug Resistance, Microbial; D004357:Drug Synergism; D017245:Foscarnet / Q000494:pharmacology*; D010455:Peptides; D010940:Plant Proteins; D018139:Simplexvirus / Q000145:classification / Q000187:drug effects* / Q000502:physiology; D013045:Species Specificity; D014709:Vero Cells / Q000187:drug effects; D014779:Virus Replication / Q000187:drug effects
D000998:Antiviral Agents; D010455:Peptides; D010940:Plant Proteins; C058031:meliacin; D017245:Foscarnet