[Fenibut and fenazepam as potential protectors of pregnancy with a GABA-ergic mechanism of action].
It has been shown that the GABAergic system of the myometrium takes part in regulation of uterine contractility during the development of pregnancy Fenibut and phenazepam exhibit a specific uterotropic effect. The uterodepressant effect of fenibut is realized via the inhibiting GABA-receptors of the myometrium. The uteroinhibiting effect of phenazepam is mediated through the interaction with the postsynaptic GABA-benzodiazepin-C1-receptor complex of the myometrium.
Sergeev
P V
PV
Sizov
P I
PI
Dukhanin
A S
AS
D000818:Animals; D014151:Anti-Anxiety Agents; D001569:Benzodiazepines; D001570:Benzodiazepinones / Q000494:pharmacology*; D004031:Diestrus / Q000187:drug effects; D005260:Female; D018682:GABA Agents / Q000494:pharmacology*; D009215:Myometrium / Q000187:drug effects; D010052:Ovariectomy; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects*; D011817:Rabbits; D051381:Rats; D011963:Receptors, GABA-A / Q000187:drug effects; D013997:Time Factors; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000494:pharmacology
D014151:Anti-Anxiety Agents; D001570:Benzodiazepinones; D018682:GABA Agents; D011963:Receptors, GABA-A; D001569:Benzodiazepines; C017928:phenazepam; D005680:gamma-Aminobutyric Acid; C008842:4-amino-3-phenylbutyric acid