Preliminary evaluation of primaquine activity on rodent malaria model after transdermal administration.
The aim of this preliminary study was to investigate the potential use of the transdermal route for primaquine administration in the treatment of malaria. Thus the activity of this drug on asexual blood forms of two rodent malaria parasites (P. v. petteri and P. y. nigeriensis) was evaluated following a single TTS patch application. Sustained plasma concentration values were observed for about 60 hours. The results obtained from a prepatency test showed that primaquine was more active towards P. v. petteri than P. y. nigeriensis. This preliminary study showed that the transdermal route for primaquine administration may be a promising strategy for improving the treatment of malaria in both causal prophylactic and prevention of relapses infection.
Mayorga
P
P
Laboratoire de Physico-Chimie, Pharmacotechnie et Biopharmacie, URA CNRS 1218, Université Paris-Sud, Chatenay-Malabry, France.
Deharo
E
E
Landau
I
I
Couarraze
G
G
D000279:Administration, Cutaneous; D000818:Animals; D000962:Antimalarials / Q000008:administration & dosage / Q000097:blood*; D004195:Disease Models, Animal; D004341:Drug Evaluation; D008288:Malaria / Q000097:blood / Q000188:drug therapy* / Q000469:parasitology; D051379:Mice; D018512:Parasitemia / Q000188:drug therapy; D011319:Primaquine / Q000008:administration & dosage / Q000097:blood*
D000962:Antimalarials; D011319:Primaquine