title: Effect of DV-7028, a novel serotonin 5-HT2 receptor antagonist on the cardiovascular system in rats.
abstract: The response of the cardiovascular system to DV-7028 demonstrated the complex action of this substance. In anaesthetized rats DV-7028 decreased the blood pressure and heart rate. These effects did not occur in pithed rats. The hypotensive action and bradycardia was partially reduced in vagotomized animals. DV-7028 potently inhibited the vasoconstrictory effects of serotonin in isolated perfused hindlegs of rat and caused a concentration-dependent shift to the right of response curve to serotonin in the rat tail artery. The present data demonstrate that DV-7028 is a potent 5-HT2 receptor antagonist. Besides its peripheral action, DV-7028 exerts central effects which cause hypotension and bradycardia.
authors.affiliation: Department of Pharmacodynamics, Medical Academy, Białystok, Poland.
authors.forename: D
authors.initials: D
authors.lastname: Pawlak
authors.forename: J
authors.initials: J
authors.lastname: Małyszko
authors.forename: M
authors.initials: M
authors.lastname: Myśliwiec
authors.forename: A
authors.initials: A
authors.lastname: Takada
authors.forename: W
authors.initials: W
authors.lastname: Buczko
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001808:Blood Vessels / Q000187:drug effects; D002319:Cardiovascular System / Q000187:drug effects*; D003655:Decerebrate State; D006339:Heart Rate / Q000187:drug effects; D006614:Hindlimb / Q000098:blood supply; D066298:In Vitro Techniques; D010880:Piperidines / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012701:Serotonin / Q000494:pharmacology; D012702:Serotonin Antagonists / Q000494:pharmacology*; D013623:Tail / Q000098:blood supply; D014227:Triazines / Q000494:pharmacology*; D014628:Vagotomy; D014662:Vasoconstrictor Agents / Q000494:pharmacology
chemical_list: D010880:Piperidines; D012702:Serotonin Antagonists; D014227:Triazines; D014662:Vasoconstrictor Agents; C073727:DV 7028; D012701:Serotonin