Ultrastructural changes in the small bowel epithelium after total gastrectomy.
The purpose of the study was to analyze ultrastructural changes in the small bowel mucosa in patients after total gastrectomy. We studied mucosal specimens obtained from 25 patients during control gastroscopy. The specimens were routinely processed for examination in transmission electron microscopy. Early after the operation (up to 6 months) we observed marked inflammatory reaction, disordered architecture of the small bowel mucosa epithelium, the presence of dysplasia-like changes and foci of dysplasia. Later on the structure of the mucosa returned to normality. Only a few dysplastic changes were seen. No relationship was found between altered epithelial structure and type of operation. In conclusion, the epithelium of the small bowel does not transform to a gastric type epithelium.
Banasiewicz
T
T
Department of Clinical Pathomorphology, Medical School, Poznan.
Majewski
P
P
Marciniak
R
R
Drews
M
M
Biczysko
M
M
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004848:Epithelium / Q000473:pathology / Q000648:ultrastructure; D005260:Female; D005743:Gastrectomy / Q000009:adverse effects; D006801:Humans; D007413:Intestinal Mucosa / Q000473:pathology / Q000648:ultrastructure; D007421:Intestine, Small / Q000473:pathology / Q000648:ultrastructure*; D008297:Male; D008875:Middle Aged; D011178:Postgastrectomy Syndromes / Q000473:pathology