title: Routine prenatal screening for congenital heart disease: what can be expected? A decision-analytic approach.
abstract: OBJECTIVE
  This study assessed the potential impact of fetal ultrasound screening on the number of newborns affected by cardiac anomalies.
  
  
  METHODS
  A decision model was developed that included the prevalence and history of congenital heart disease, characteristics of ultrasound, risk of abortion, and attitude toward pregnancy termination. Probabilities were obtained with a literature survey; sensitivity analysis showed their influence on expected outcomes.
  
  
  RESULTS
  Presently, screening programs may prevent the birth of approximately 1300 severely affected newborns per million second-trimester pregnancies. However, over 2000 terminations of pregnancy would be required, 750 of which would have ended in intrauterine death or spontaneous abortion. Further, 9900 false-positive screening results would occur, requiring referral. Only the sensitivity of routine screening and attitude toward termination of pregnancy appeared to influence the yield substantially.
  
  
  CONCLUSIONS
  The impact of routine screening for congenital heart disease appeared relatively small. Further data may be required to fully assess the utility of prenatal screening.
authors.affiliation: Department of Epidemiology and Biosatatistics, Rotterdam, The Netherlands.
authors.forename: E
authors.initials: E
authors.lastname: Buskens
authors.forename: E W
authors.initials: EW
authors.lastname: Steyerberg
authors.forename: J
authors.initials: J
authors.lastname: Hess
authors.forename: J W
authors.initials: JW
authors.lastname: Wladimiroff
authors.forename: D E
authors.initials: DE
authors.lastname: Grobbee
mesh_terms: D000022:Abortion, Spontaneous; D001290:Attitude; D003661:Decision Support Techniques; D003955:Diagnostic Tests, Routine; D005260:Female; D006330:Heart Defects, Congenital / Q000175:diagnosis* / Q000000981:diagnostic imaging; D006801:Humans; D008403:Mass Screening; D015999:Multivariate Analysis; D011237:Predictive Value of Tests; D011247:Pregnancy; D011256:Pregnancy Outcome; D011296:Prenatal Diagnosis; D012680:Sensitivity and Specificity; D016216:Ultrasonography, Prenatal