title: [Magnetic resonance angiography in stenosing-occlusive diseases of the carotid arteries: 3D with time of flight versus 3D with phase contrast].
abstract: We assessed the comparative sensitivity, specificity and diagnostic accuracy of 3D time of flight (TOF) versus 3D phase contrast (PC) MRA in the study of stenoses/occlusions of the extracranial carotid artery. Fifty-four patients were submitted to MRA because of their symptoms or of signs of cerebrovascular insufficiency. 3D TOF and 3D PC axial slices were acquired with a high field magnet; digital angiography was the gold standard. The parameters of 3D TOF acquisitions were: TR/TE/FA 50/8/20, 1 NEX, 512 x 256 matrix, 16 x 12 FOV, 1 axial slab of 60 slices, 1 mm slice thickness, superior presaturation band, ramp pulse, TA 10-18 minutes. 3D PC parameters were: TR/TE/ FA 25/9/20, 1 NEX, 256 x 128 matrix, 18 x 13 FOV, 1 axial slab of 60 slices, 1 mm slice thickness, VENC 35 cm/s, TA 10-15 minutes. 3D TOF MRA was in agreement with digital angiography in 95.6% of cases (22/23), overestimating a grade 3 stenosis as grade 4 (one case, 4.3%) and underestimating no stenoses. 3D PC MRA was in agreement with digital angiography in 78.2% of cases (18/23), overestimating three stenoses (13%); one grade 1 as grade 2 and two grade 4 as grade 5; two stenoses were underestimated (8.6%); one grade 4 as grade 3 and one grade 4 as grade 2. Sensitivity, specificity and diagnostic accuracy were 91.4%, 98.9% and 95.7% for 3D TOF, versus 83.2%, 97.2% and 92.3% for 3D PC, respectively. The two MRA techniques had different semiology. In spite of outstanding background noise suppression, 3D PC poorly depicted the turbulent flow at the carotid bifurcation in carotid stenoses. Therefore, 3D TOF appears a better technique to study stenoses/occlusions of the extracranial carotid arteries.
authors.affiliation: Dipartimento di Diagnostica per Immagini, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo FG.
authors.forename: T
authors.initials: T
authors.lastname: Scarabino
authors.forename: A
authors.initials: A
authors.lastname: Carriero
authors.forename: N
authors.initials: N
authors.lastname: Magarelli
authors.forename: F
authors.initials: F
authors.lastname: Nemore
authors.forename: F
authors.initials: F
authors.lastname: Florio
authors.forename: V
authors.initials: V
authors.lastname: D'Angelo
authors.forename: L
authors.initials: L
authors.lastname: Bonomo
authors.forename: U
authors.initials: U
authors.lastname: Salvolini
mesh_terms: D016893:Carotid Stenosis / Q000473:pathology*; D006801:Humans; D018810:Magnetic Resonance Angiography / Q000379:methods; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity