Dynamics of magnetization in hyperpolarized gas MRI of the lung.
The magnetization in hyperpolarized gas (HP) MRI is generated by laser polarization that is independent of the magnet and imaging process. As a consequence, there is no equilibrium magnetization during the image acquisition. The competing processes of gas inflow and depolarization of the spins lead to large changes in signal as one samples k-space. A model is developed of dynamic changes in polarization of hyperpolarized 3He during infusion and in vivo imaging of the lung and verified experimentally in a live guinea pig. Projection encoding is used to measure the view-to-view variation with temporal resolution < 4 ms. Large excitation angles effectively sample the magnetization in the early stages of inflow, highlighting larger airways, while smaller excitation angles produce images of the more distal spaces. The work provides a basis for pulse sequences designed to effectively exploit HP MRI in the lung.
Johnson
G A
GA
Center for In Vivo Microscopy, Duke University Medical Center, Durham, North Carolina 27710, USA.
Cates
G
G
Chen
X J
XJ
Cofer
G P
GP
Driehuys
B
B
Happer
W
W
Hedlund
L W
LW
Saam
B
B
Shattuck
M D
MD
Swartz
J
J
D000818:Animals; D006168:Guinea Pigs; D006371:Helium; D007554:Isotopes; D008168:Lung / Q000033:anatomy & histology*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D012119:Respiration
D007554:Isotopes; D006371:Helium