Effects of vasodilators on the signal intensity of perfluorocarbon monitored by in vivo 19F-NMR spectroscopy.
The effects of vasodilators on peripheral vessels were examined by monitoring the 19F-NMR signal of perfluorocarbon in vivo. Nitroglycerin, a venodilator that acts mainly on venous smooth muscle, increased the signal intensity of FC-43, whereas hydralazine, a typical arteriolar dilator that acts on arteriolar smooth muscle, decreased the signal intensity. These results indicate that the in vivo effects of vasodilators on smooth muscles of the venous and arterial systems are reflected by their effects on the signal intensity of FC-43.
Sogabe
T
T
Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd., Japan.
Imaizumi
T
T
Mori
T
T
Tominaga
M
M
Koga
K
K
Yabuuchi
Y
Y
D000818:Animals; D001160:Arterioles / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D001808:Blood Vessels / Q000187:drug effects*; D001810:Blood Volume / Q000187:drug effects; D005461:Fluorine; D005466:Fluorocarbons; D006339:Heart Rate / Q000187:drug effects; D006614:Hindlimb / Q000098:blood supply; D006830:Hydralazine / Q000494:pharmacology; D007089:Image Enhancement; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D018482:Muscle, Skeletal / Q000098:blood supply; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D005996:Nitroglycerin / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012039:Regional Blood Flow / Q000187:drug effects; D012965:Sodium Chloride; D014665:Vasodilator Agents / Q000494:pharmacology*; D014680:Veins / Q000187:drug effects
D005466:Fluorocarbons; D014665:Vasodilator Agents; D006830:Hydralazine; D005461:Fluorine; D012965:Sodium Chloride; D005996:Nitroglycerin