Characterization of a mammalian cell death gene Nedd2.
Through subtraction cloning approach, we have identified a set of mouse genes with developmentally down-regulated expression in brain. One such gene, termed Nedd2, was found to encode protein similar to the mammalian interleukin-1b-converting enzyme (ICE) and the product of the nematode (C. elegans) cell death gene ced-3. Our data suggest that Nedd2 is an important component of the mammalian programmed cell death machinery.
Kumar
S
S
Department of Molecular Oncology, Kyoto University Graduate School of Medicine, Japan.
Kinoshita
M
M
Noda
M
M
D000818:Animals; D017209:Apoptosis / Q000235:genetics*; D017173:Caenorhabditis elegans / Q000235:genetics; D029742:Caenorhabditis elegans Proteins; D020170:Caspase 1; D053143:Caspase 2; D020169:Caspases; D002455:Cell Division; D002490:Central Nervous System / Q000166:cytology / Q000196:embryology; D003001:Cloning, Molecular; D003546:Cysteine Endopeptidases / Q000096:biosynthesis / Q000235:genetics*; D004622:Embryo, Mammalian; D004625:Embryo, Nonmammalian; D008322:Mammals; D051379:Mice; D009474:Neurons / Q000166:cytology; D011994:Recombinant Proteins / Q000096:biosynthesis
D029742:Caenorhabditis elegans Proteins; D011994:Recombinant Proteins; C090208:Casp2 protein, mouse; D053143:Caspase 2; D020169:Caspases; D003546:Cysteine Endopeptidases; C089223:ced-3 protein, C elegans; D020170:Caspase 1