title: Pathogenesis of gastric lymphoma: the enigma in Hong Kong.
abstract: BACKGROUND
  Helicobacter pylori (H. pylori) infection has been postulated to be a pathogenetic factor in gastric lymphoma. However, the etiological factors for gastric lymphoma could vary in different populations.
  
  
  METHODS
  We looked for histological evidence of H. pylori infection in 53 gastrectomy specimens from Hong Kong Chinese patients with primary gastric B-lymphoma. We also screened for Epstein-Barr virus (EBV) in these cases using in situ hybridization with oligonucleotide probes for EBV-encoded small RNA1 and 2.
  
  
  RESULTS
  H. pylori was found in 29 of 53 (55%), including 8 of 13 (62%) cases of low-grade lymphoma of mucosa-associated lymphoid tissue (MALT) type. These infection rates in gastric lymphoma are lower than those reported in Western populations (80%-100%) and comparable to that found in healthy Chinese blood donors (55%) or in non-ulcer dyspeptic patients (52%-57%). EBV was found in tumor cells only in one case of high-grade gastric lymphoma with low-grade MALT component which was H. pylori-negative, and in occasional nontumor-lymphoid cells in 7 other cases.
  
  
  CONCLUSIONS
  These results suggest that (1) the role of H. pylori in pathogenesis of gastric lymphoma may vary in different populations; (2) very few gastric lymphomas are associated with EBV; (3) not all low-grade gastric MALT lymphomas are H. pylori-dependent.
authors.affiliation: Department of Pathology, University of Hong Kong, Hong Kong.
authors.forename: W S
authors.initials: WS
authors.lastname: Xu
authors.forename: F C
authors.initials: FC
authors.lastname: Ho
authors.forename: J
authors.initials: J
authors.lastname: Ho
authors.forename: A C
authors.initials: AC
authors.lastname: Chan
authors.forename: G
authors.initials: G
authors.lastname: Srivastava
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002051:Burkitt Lymphoma / Q000453:epidemiology / Q000821:virology*; D005260:Female; D004854:Herpesvirus 4, Human / Q000302:isolation & purification*; D006723:Hong Kong; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000821:virology*; D014412:Tumor Virus Infections / Q000453:epidemiology / Q000821:virology*