title: Liquid chromatographic analysis of cocaine and benzoylecgonine in plasma of traditional coca chewers from Bolivia during exercise.
abstract: The purpose of the present study was to determine the amount of cocaine and benzoylecgonine in the plasma of Aymara Indians from the Bolivian Andes after traditional chewing of coca leaves during exercise performance. The determination was carried out by high performance liquid chromatography after solid-liquid extraction. The results showed that such use of coca leaves is well correlated with pharmacologically active concentration of cocaine in plasma.
authors.affiliation: Instituto Boliviano de Biología de Altura, Universidad Mayor de San Andres, La Paz, Bolivia.
authors.forename: C
authors.initials: C
authors.lastname: Rerat
authors.forename: M
authors.initials: M
authors.lastname: Sauvain
authors.forename: P P
authors.initials: PP
authors.lastname: Rop
authors.forename: E
authors.initials: E
authors.lastname: Ruiz
authors.forename: M
authors.initials: M
authors.lastname: Bresson
authors.forename: A
authors.initials: A
authors.lastname: Viala
mesh_terms: D000328:Adult; D001838:Bolivia; D002851:Chromatography, High Pressure Liquid; D003041:Coca; D003042:Cocaine / Q000031:analogs & derivatives* / Q000097:blood*; D015444:Exercise; D006801:Humans; D007199:Indians, South American; D008297:Male; D008875:Middle Aged; D010946:Plants, Medicinal
chemical_list: C005618:benzoylecgonine; D003042:Cocaine