[Urine level of trans, trans-muconic acid used as an index of internal dose of exposure to benzene].
Urine trans, trans-muconic acid (TTMA) in population exposed to benzene was determined with a high performance liquid chromatography-ultra violet detection system. Result showed urine TTMA increased significantly with increasing of air benzene levels, showing a good correlationship between them (r = 0.940, P < 0.05). Even in relatively low air benzene levels (with an average of 2.46 mg/m3), urine TTMA in exposed group was higher, as compared with that in controls, and their difference reached statistically significant level. It suggests that urine TTMA level can be used as a sensitive and specific indicator for biological monitoring, especially for low exposure to benzene. There was no significant difference in urine TTMA between males and females exposed. Urine TTMA formation can be inhibited by toluene, and confounding of toluene can be roughly adjusted by analysis of covariance.
Liu
L
L
Department of Genotoxicology, Sun Yat-Sen University of Medical Sciences, Guangzhou.
Zhang
Q
Q
Feng
J
J
D000328:Adult; D001554:Benzene / Q000378:metabolism; D004781:Environmental Exposure; D005260:Female; D006801:Humans; D008297:Male; D016273:Occupational Exposure; D013011:Sorbic Acid / Q000031:analogs & derivatives* / Q000032:analysis
C005939:muconic acid; D001554:Benzene; D013011:Sorbic Acid