Effects of [arginine8, glycine-OH9]-vasopressin on pentylenetetrazol seizures in mice. Interaction with adrenaline.
The effects of [arginine8, glycine-OH9]-vasopressin (AGV), alone and in combination with adrenaline, on pentylenetetrazol (PTZ) seizure threshold by timed intravenous infusion in tall vein and intensity by subcutaneous (s.c.) PTZ test (85 mg/kg) were studied in male albino mice. AGV was administered intracerebroventricularly (i.c.v.) at doses of 0.001, 0.01, 0.1, 1.0 and 5.0 ng/mouse 5, 15 and 30 min prior to PTZ AGV induced decrease of seizure threshold at middle doses (0.01 and 0.1) 5 and 15 min prior to PTZ (75 and 67% respectively vs. controls). Adrenaline (1 mg/kg, i.p.) potentiated the effect of AGV on seizure threshold. AGV also induced increase of seizure intensity at doses of 0.01 and 1.0 ng and decrease of latency of the first tonic seizure. Adrenaline (1.0 mg/kg, i.p.) enhanced the effects of AGV suggesting interactions of vasopressin with adrenergic neurotransmission in the CNS.
Lambadjieva
N D
ND
Department of Physiology, Faculty of Biology, University of Sofia, Bulgaria.
Georgiev
V P
VP
Kambourova
T S
TS
D000818:Animals; D001127:Arginine Vasopressin / Q000031:analogs & derivatives* / Q000494:pharmacology; D003292:Convulsants / Q000633:toxicity; D004357:Drug Synergism; D004837:Epinephrine / Q000494:pharmacology*; D008297:Male; D051379:Mice; D018377:Neurotransmitter Agents / Q000494:pharmacology*; D010433:Pentylenetetrazole / Q000633:toxicity; D012640:Seizures / Q000139:chemically induced / Q000503:physiopathology*
D003292:Convulsants; D018377:Neurotransmitter Agents; D001127:Arginine Vasopressin; C107065:argipressin, Gly(OH9)-; D010433:Pentylenetetrazole; D004837:Epinephrine