Cerebral ischemia and white matter edema in experimental hydrocephalus: a combined in vivo MRI and MRS study.
T2 and diffusion weighted MRI, as well as 31P and 1H MRS were performed in kaolin-induced hydrocephalic rats. Extracellular white matter edema was detected in the early stages of progressive hydrocephalus. Phosphocreatine (PCr)/inorganic phosphate (Pi) ratios in hydrocephalic animals were decreased compared to controls, and lactate was detected during the acute and chronic stages of hydrocephalus. These MR spectroscopic results are indicative of a compromised energy metabolism and suggest the occurrence of cerebral ischemia in experimental hydrocephalus.
Braun
K P
KP
Department of Neurology, University Hospital Utrecht, The Netherlands. braun@bijvoet.ruu.nl
Dijkhuizen
R M
RM
de Graaf
R A
RA
Nicolay
K
K
Vandertop
W P
WP
Gooskens
R H
RH
Tulleken
K A
KA
D000818:Animals; D001921:Brain / Q000378:metabolism; D001929:Brain Edema / Q000209:etiology* / Q000378:metabolism; D002545:Brain Ischemia / Q000209:etiology* / Q000378:metabolism; D004734:Energy Metabolism; D006849:Hydrocephalus / Q000150:complications* / Q000378:metabolism; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D010710:Phosphates / Q000378:metabolism; D010725:Phosphocreatine / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
D010710:Phosphates; D010725:Phosphocreatine