Primary prevention of HTLV-1 in Japan.
The Nagasaki Prefecture, Japan (population: 1.5 million), is one of the hot endemic foci of Human T-lymphotropic virus type 1 (HTLV-1). Prevalence of HTLV-1 carriers are approximately 10% in the age group over 40 years old (40,000 individuals), approximately 10 times of the national average. Annual registry of adult T-cell leukemia (ATL) in the Prefecture is approximately 60 cases (estimated incidence: 100 cases), or a half percent of total deaths. A effective measure to control the endemic cycle of HTLV-1 has been imperative, since practical ways to prevent or control ATL are not available. A prefecture wide intervention at Nagasaki by refrain from breast-feeding blocked approximately 80% of mother-to-child transmission of HTLV-1.
Hino
S
S
Department of Virology, Faculty of Medicine, Tottori University, Yonago, Japan.
Katamine
S
S
Miyata
H
H
Tsuji
Y
Y
Yamabe
T
T
Miyamoto
T
T
D000328:Adult; D001942:Breast Feeding / Q000009:adverse effects*; D002353:Carrier State / Q000453:epidemiology; D005260:Female; D015490:HTLV-I Infections / Q000453:epidemiology / Q000517:prevention & control* / Q000635:transmission; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control*; D007564:Japan / Q000453:epidemiology; D015458:Leukemia, T-Cell / Q000453:epidemiology / Q000517:prevention & control / Q000821:virology; D010865:Pilot Projects; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000453:epidemiology / Q000821:virology*; D015995:Prevalence; D011322:Primary Prevention