title: Respiratory impedances and acinar gas transfer in a canine model for emphysema.
abstract: We examined how the changes in the acini caused by emphysema affected gas transfer out of the acinus (Taci) and lung and chest wall mechanical properties. Measurements were taken from five dogs before and 3 mo after induction of severe bilateral emphysema by exposure to papain aerosol (170-350 mg/dose) for 4 consecutive wk. With the dogs anesthetized, paralyzed, and mechanically ventilated at 0.2 Hz and 20 ml/kg, we measured Taci by the rate of washout of 133Xe from an area of the lung with occluded blood flow. Measurements were repeated at positive end-expiratory pressures (PEEP) of 10, 5, 15, 0, and 20 cmH2O. We also measured dynamic elastances and resistances of the lungs (EL and RL, respectively) and chest wall at the different PEEP and during sinusoidal forcing in the normal range of breathing frequency and tidal volume. After final measurements, tissue sections from five randomly selected areas of the lung each showed indications of emphysema. Taci during emphysema was similar to that in control dogs. EL decreased by approximately 50% during emphysema (P < 0.05) but did not change its dependence on frequency or tidal volume. RL did not change (P > 0.05) at the lowest frequency studied (0.2 Hz), but in some dogs it increased compared with control at the higher frequencies. Chest wall properties were not changed by emphysema (P > 0.05). We suggest that although large changes in acinar structure and EL occur during uncomplicated bilateral emphysema, secondary complications must be present to cause several of the characteristic dysfunctions seen in patients with emphysema.
authors.affiliation: Department of Anesthesiology, University of Maryland, Baltimore, Maryland 21201, USA.
authors.forename: G M
authors.initials: GM
authors.lastname: Barnas
authors.forename: P A
authors.initials: PA
authors.lastname: Delaney
authors.forename: I
authors.initials: I
authors.lastname: Gheorghiu
authors.forename: S
authors.initials: S
authors.lastname: Mandava
authors.forename: R G
authors.initials: RG
authors.lastname: Russell
authors.forename: R
authors.initials: R
authors.lastname: Kahn
authors.forename: C F
authors.initials: CF
authors.lastname: Mackenzie
mesh_terms: D000336:Aerosols; D000403:Airway Resistance / Q000502:physiology*; D000818:Animals; D004285:Dogs; D005260:Female; D006439:Hemodynamics / Q000502:physiology; D008168:Lung / Q000473:pathology / Q000503:physiopathology; D008176:Lung Volume Measurements; D010206:Papain / Q000008:administration & dosage; D011656:Pulmonary Emphysema / Q000139:chemically induced / Q000473:pathology / Q000503:physiopathology*; D011659:Pulmonary Gas Exchange / Q000502:physiology*; D012044:Regression Analysis; D012129:Respiratory Function Tests
chemical_list: D000336:Aerosols; D010206:Papain