Fine-needle aspiration cytologic findings in a case of lymph node tumor of plasmacytoid monocytes.
We present a unique case of fine-needle aspiration (FNA) from a lymph node with subsequent histologic diagnosis of tumor of plasmacytoid monocytes (PMs). The patient had an associated myeloproliferative disease which terminated into an acute myelomonocytic leukemia. In a 95% ethanol-fixed, hematoxylin-eosin (H&E)-stained smear, the tumor cells appeared monomorphic, medium size, with oval to indented nuclei, finely stippled chromatin, and small nucleoli; the cytoplasm was scanty and slightly eccentric. The cytologic picture suggested some subtypes of small-cell non-Hodgkin's lymphomas or a leukemic infiltration. In the FNA specimen, the cells appeared immunocytochemically negative for some B- and T-cell markers (MB2, L26, LN1, and UCHL1) and strongly positive to KP1, a known histyocyte-macrophage and myeloid marker. The FNA differentiated diagnoses are discussed.
Fontana
P
P
Department of Pathology, Hospital of Desenzano del Garda, Brescia, Italy.
Facchetti
F
F
Fiaccavento
S
S
D001707:Biopsy, Needle; D001853:Bone Marrow / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D007952:Leukemia, Plasma Cell / Q000473:pathology*; D008198:Lymph Nodes / Q000473:pathology