title: [Effect of hemodilution with dextran and albumin on activated clotting time (ACT)].
abstract: Hemodilution with colloid solution is known to influence blood coagulation. To evaluate the effectiveness of hemodilution on ACT, 156 patients undergoing elective coronary artery bypass grafting were studied. Patients were divided into three groups (Group I of 52: without hemodilution, Group II of 52: normovolemic hemodilution with Dextran 40, Group III of 52: albumin and lactated Ringer solution). Systemic heparin was given (300 IU.kg-1. ACT was measured by Hemochron 400 and maintained higher than 400 seconds with supplemental dose of heparin. Sampling was performed after induction in Group I, after hemodilution in other groups, after heparin administration, was after start of CPB. More supplemental dose of heparin were required to achieve the lower limit of ACT (400 seconds) in the group I. The ACT at any sampling point was significantly higher in the group II and III than in the group I. In conclusion, hemodilution with dextran and albumin increased ACT values and heparin effect.
authors.affiliation: Department of Anesthesia, Kanagawa Prefectural Cardiovascular and Respiratory Center, Yokohama.
authors.forename: M
authors.initials: M
authors.lastname: Inoue
authors.forename: Y
authors.initials: Y
authors.lastname: Hirose
authors.forename: M
authors.initials: M
authors.lastname: Gamou
authors.forename: M
authors.initials: M
authors.lastname: Goto
mesh_terms: D000328:Adult; D000368:Aged; D000418:Albumins; D001804:Blood Transfusion, Autologous; D001026:Coronary Artery Bypass; D003911:Dextrans; D017558:Elective Surgical Procedures; D006438:Hemodilution; D006493:Heparin / Q000008:administration & dosage; D006801:Humans; D012189:Retrospective Studies; D014914:Whole Blood Coagulation Time
chemical_list: D000418:Albumins; D003911:Dextrans; D006493:Heparin