title: Portal vein thrombosis in association with factor V Leiden mutation in a patient with hepatocellular carcinoma.
abstract: We report a case of hepatocellular carcinoma associated with portal vein thrombosis. Analysis of whole cellular DNA demonstrated heterozygosity for the factor V Leiden mutation. The patient also had marked protein C deficiency. The presence of the mutation associated with protein C deficiency may increase the risk of thrombosis in this patient with hepatocellular carcinoma.
authors.affiliation: Department of Pediatrics, Hacettepe University, Ihsan Dogramaci Children Hospital, Ankara, Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Gürgey
authors.forename: M
authors.initials: M
authors.lastname: Büyükpamukcu
authors.forename: C
authors.initials: C
authors.lastname: Baskut
authors.forename: B
authors.initials: B
authors.lastname: Yalcin
authors.forename: S
authors.initials: S
authors.lastname: Gögüş
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000150:complications* / Q000235:genetics; D002648:Child; D004273:DNA, Neoplasm / Q000235:genetics; D005165:Factor V / Q000235:genetics*; D006579:Heterozygote; D006801:Humans; D008113:Liver Neoplasms / Q000150:complications* / Q000235:genetics; D008297:Male; D009154:Mutation / Q000235:genetics*; D011169:Portal Vein / Q000473:pathology*; D020151:Protein C Deficiency; D013927:Thrombosis / Q000097:blood / Q000209:etiology* / Q000235:genetics
chemical_list: D004273:DNA, Neoplasm; C095381:factor V Leiden; D005165:Factor V