Running exercise may reduce risk for lung and liver cancer by inducing activity of antioxidant and phase II enzymes.
The effects of exercise, ethanol, and exercise plus ethanol-treatments on activity of superoxide dismutase (SOD), catalase (CAT), glutathione-S-transferase (GST) and UDP-glucuronosyl transferase (UDP-GT) in lung and liver were investigated. All treatments induced SOD and CAT activity in the lung while CAT activity was enhanced only by the combined treatments in the liver. Ethanol reduced hepatic SOD activity, while with the combined treatment SOD was normal. Exercise enhanced UDP-GT activity in liver and lung while ethanol had no effect and GST activity was induced in the liver by the combined treatment. Thus exercise may reduce risk for lung and hepatic cancer and prevent an ethanol-induced increase in risk for hepatic cancer by enhancing activity of antioxidant and phase II enzymes.
Duncan
K
K
Department of Biological and Exercise Sciences, Northeastern Illinois University, Chicago 60625, USA.
Harris
S
S
Ardies
C M
CM
D000818:Animals; D002374:Catalase / Q000096:biosynthesis; D004790:Enzyme Induction; D014453:Glucuronosyltransferase / Q000096:biosynthesis; D005982:Glutathione Transferase / Q000096:biosynthesis; D008114:Liver Neoplasms, Experimental / Q000201:enzymology / Q000517:prevention & control*; D008175:Lung Neoplasms / Q000201:enzymology / Q000517:prevention & control*; D008297:Male; D010805:Physical Conditioning, Animal; D051381:Rats; D017207:Rats, Sprague-Dawley; D012306:Risk; D013482:Superoxide Dismutase / Q000096:biosynthesis
D002374:Catalase; D013482:Superoxide Dismutase; D014453:Glucuronosyltransferase; D005982:Glutathione Transferase