Antihyperglycemic activity of phenolics from Pterocarpus marsupium.
Glucose levels in rats with hyperglycemia induced by streptozotocin were determined after i.p. administration of marsupsin (1), pterosupin (2), and pterostilbene (3), three important phenolic constituents of the heartwood of Pterocarpus marsupium. Marsupsin and pterostilbene significantly lowered the blood glucose level of hyperglycemic rats, and the effect was comparable to that of 1,1-dimethylbiguanide (metformin).
Manickam
M
M
Department of Medicinal Chemistry, Banaras Hindu University, Varanasi, India.
Ramanathan
M
M
Jahromi
M A
MA
Chansouria
J P
JP
Ray
A B
AB
D000818:Animals; D001572:Benzofurans / Q000302:isolation & purification* / Q000494:pharmacology; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D003408:Cresols / Q000302:isolation & purification* / Q000494:pharmacology; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy; D005260:Female; D005960:Glucosides / Q000302:isolation & purification* / Q000494:pharmacology; D007004:Hypoglycemic Agents / Q000302:isolation & purification* / Q000494:pharmacology; D008297:Male; D008687:Metformin / Q000494:pharmacology; D010636:Phenols / Q000302:isolation & purification* / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D013267:Stilbenes / Q000302:isolation & purification* / Q000494:pharmacology; D014934:Wood
D001572:Benzofurans; D001786:Blood Glucose; D003408:Cresols; D005960:Glucosides; D007004:Hypoglycemic Agents; D010636:Phenols; D013267:Stilbenes; C107773:pterostilbene; C083153:pterosupin; C083154:marsupsin; D008687:Metformin