title: Cardiovascular defects among the progeny of mouse phenylketonuria females.
abstract: In a genetic mouse model of human phenylketonuria we have examined the offspring of hyperphenylalaninemic mothers for the presence of cardiovascular defects, an important feature of the pathology of the human maternal phenylketonuria syndrome. Beginning at 14.5 d after conception (75% through gestation), a variety of cardiovascular defects became apparent among the progeny of the hyperphenylalaninemic females. These defects ranged from mild to serious and correlated with the maternal but not the fetal Pah genotype. Nearly all of the defects were vascular, however, whereas the most reported in humans so far have been cardiac. The predisposing biochemical condition in this mouse disease model seems to be the same as in the human disease; elevated maternal blood phenylalanine levels concentrated across the placental barrier to produce a teratogenic developmental environment. This model for congenital cardiovascular defects should enhance two related areas of research. 1) It should allow a more thorough investigation of the relationship between maternal diet and maternal phenylketonuria birth defects, and 2) it should provide an experimental tool to gain insight into the normal process of cardiovascular development.
authors.affiliation: Department of Biological Sciences, Wichita State University, Kansas 67260-0026, USA.
authors.forename: J D
authors.initials: JD
authors.lastname: McDonald
authors.forename: C A
authors.initials: CA
authors.lastname: Dyer
authors.forename: L
authors.initials: L
authors.lastname: Gailis
authors.forename: M L
authors.initials: ML
authors.lastname: Kirby
mesh_terms: D000818:Animals; D001808:Blood Vessels / Q000002:abnormalities*; D004032:Diet; D004195:Disease Models, Animal; D005260:Female; D005838:Genotype; D006330:Heart Defects, Congenital / Q000209:etiology / Q000235:genetics*; D006801:Humans; D008431:Maternal-Fetal Exchange; D051379:Mice; D010649:Phenylalanine / Q000097:blood; D010661:Phenylketonurias / Q000150:complications / Q000178:diet therapy / Q000235:genetics*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000178:diet therapy
chemical_list: D010649:Phenylalanine