title: Antimicrobial activity of some 13-alkyl substituted protoberberinium salts.
abstract: Several 13-alkyl substituted analogs of berberine and palmatine were found to be highly active against two types of Staphylococcus aureus (S1 and S2) of different origin. The most active 13-hexylberberine was 8 times more active (against S1) and the same order active (against S2) as kanamycin sulfate. 13-Hexylpalmatine displayed an activity against S. aureus (S1) 4 times greater than that of kanamycin sulfate. The activities of 13-hexylberberine against two types of S. aureus were 64 and 128 times greater than those of the clinically used alkaloid berberine. Additionally two hexyl derivatives possessed antifungal activity.
authors.affiliation: Kobe Pharmaceutical University, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Iwasa
authors.forename: M
authors.initials: M
authors.lastname: Kamigauchi
authors.forename: M
authors.initials: M
authors.lastname: Sugiura
authors.forename: H
authors.initials: H
authors.lastname: Nanba
mesh_terms: D001599:Berberine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology*; D001600:Berberine Alkaloids / Q000737:chemistry / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D013211:Staphylococcus aureus / Q000187:drug effects*; D013329:Structure-Activity Relationship
chemical_list: C583326:13-hexylberberine; D001600:Berberine Alkaloids; D001599:Berberine; C005413:palmatine