The radioprotective power of 2-isopropyl 5-methyl 1,3-thiazolane.
The adequate conditions of radioprotective treatment with 2-isopropyl 5-methyl 1,3-thiazolane were established for mice. Protection is maximum with a unique intraperitoneal injection of LD 50/2, 3 hours prior to the irradiation. The rate of radiation dose reduction is therefore 1.75. Survival rate of whole body irradiated mice with supralethal doses were determined for 11 months. The long term survival of the animals fully proved good prevention of radio-induced damages. In vitro pharmacological studies show the ability of the major metabolite of the compound to trap organic radicals.
Schumacher
C P
CP
Laboratoire de Chimie Organique Pharmaceutique, Faculté de Pharmacie, Montpellier, France.
Robbe
Y
Y
Subra
G
G
Chanal
J L
JL
Delard
R
R
Dubois
J B
JB
D000818:Animals; D003035:Cobalt; D004305:Dose-Response Relationship, Drug; D005260:Female; D051379:Mice; D015394:Molecular Structure; D011837:Radiation-Protective Agents / Q000737:chemistry / Q000494:pharmacology*; D016019:Survival Analysis; D013844:Thiazoles / Q000737:chemistry / Q000494:pharmacology*; D013997:Time Factors; D014916:Whole-Body Irradiation
C107764:2-isopropyl-5-methyl-1,3-thiazolane; D011837:Radiation-Protective Agents; D013844:Thiazoles; D003035:Cobalt