title: Elevated albumin excretion in nonmodulating essential hypertensive patients.
abstract: Nonmodulating (NM) essential hypertensives are characterized by abnormal renal and aldosterone responses to angiotensin II. Recently, hyperinsulinemia, hypercholesterolemia, and an increased prevalence of family history of hypertension and myocardial infarction have been shown in NM hypertensives. Since an elevated urinary albumin excretion (UAE) has been indicated as a negative prognostic marker for cardiovascular diseases in essential hypertensives, we evaluated UAE in 50 male patients with mild to moderate essential hypertension (mean age 46.3 +/- 4.4 years), characterized as low renin (LR) (n = 14), modulating (M) (n = 20), and NM patients (n = 16) according to their renin profile and ability to modulate the aldosterone response to a graded infusion of angiotensin II. A group of 14 healthy male subjects (mean age 43.3 +/- 3.9 years) served as control. Resulting data showed that NM had significantly higher UAE (30.7 +/- 10.7 microg/min) than controls (11.9 +/- 2.7 microg/min, p < 0.0001), LR (22.1 +/- 8.4 microg/min, p < 0.05), and M patients (19.7 +/- 6.6 microg/min, p = 0.0001) when all fed a 200-mmol NaCl/day diet. On the contrary, differences in UAE disappeared when all subjects were on a low sodium regimen (10 mmol NaCl/day). Compared to LR and M patients, the NM ones also manifested higher low-density lipoprotein cholesterol levels (p < 0.05). Furthermore, these latter and UAE were positively correlated in NM patients (r = 0.579, p < 0.05) but not in the other subgroups. In conclusion, the current study demonstrates elevated UAE in NM patients, suggesting the NM phenotype is combined to an increased cardiovascular risk.
authors.affiliation: Andrea Cesalpino Foundation, University of Rome La Sapienza, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Baldoncini
authors.forename: C
authors.initials: C
authors.lastname: Bellini
authors.forename: G
authors.initials: G
authors.lastname: Desideri
authors.forename: C
authors.initials: C
authors.lastname: De Angelis
authors.forename: C
authors.initials: C
authors.lastname: Ferri
authors.forename: A
authors.initials: A
authors.lastname: Santucci
mesh_terms: D000328:Adult; D000419:Albuminuria / Q000209:etiology*; D000804:Angiotensin II / Q000008:administration & dosage; D001794:Blood Pressure / Q000187:drug effects; D002318:Cardiovascular Diseases / Q000209:etiology; D016022:Case-Control Studies; D004351:Drug Resistance; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000503:physiopathology / Q000652:urine; D007668:Kidney / Q000503:physiopathology; D007674:Kidney Diseases / Q000209:etiology; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D012083:Renin / Q000097:blood; D012307:Risk Factors; D012982:Sodium, Dietary / Q000008:administration & dosage
chemical_list: D012982:Sodium, Dietary; D000804:Angiotensin II; D012083:Renin