title: Uric acid and ascorbic acid redox ratios in plasma and tracheal aspirate of preterm babies with acute and chronic lung disease.
abstract: This study compared plasma redox ratios of uric acid and ascorbic acid in well preterm babies with those with respiratory distress syndrome (RDS) and chronic lung disease (CLD), and investigated the relationship between these ratios and their respective measurements in tracheal aspirate. On day 1 after birth, plasma allantoin and allantoin/uric acid ratio were elevated in CLD (p < .05), and both markers of oxidative stress enabled early prediction of development of CLD (sensitivity and specificity: 54 and 83%, respectively). The relation between allantoin production and oxidative stress is supported by the correlation between the allantoin level and oxygen therapy in both RDS and CLD (p < .05). Reduced and oxidize ascorbic acid in plasma decreased postnatally in all groups and their redox ratio remained stable. Uric acid and ascorbic acid redox ratios were significantly elevated in tracheal aspirates compared to plasma samples (p < .05), and there was a strong positive correlation between both ratios (p < .005). These markers may be useful in monitoring babies with respiratory distress.
authors.affiliation: Department of Pediatrics, Leiden University Hospital, The Netherlands.
authors.forename: R M
authors.initials: RM
authors.lastname: Moison
authors.forename: A J
authors.initials: AJ
authors.lastname: de Beaufort
authors.forename: A A
authors.initials: AA
authors.lastname: Haasnoot
authors.forename: T M
authors.initials: TM
authors.lastname: Dubbelman
authors.forename: D
authors.initials: D
authors.lastname: van Zoeren-Grobben
authors.forename: H M
authors.initials: HM
authors.lastname: Berger
mesh_terms: D000975:Antioxidants / Q000378:metabolism; D001205:Ascorbic Acid / Q000097:blood / Q000378:metabolism*; D015415:Biomarkers; D016022:Case-Control Studies; D002908:Chronic Disease; D005609:Free Radicals / Q000378:metabolism; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D008171:Lung Diseases / Q000097:blood / Q000378:metabolism*; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D017382:Reactive Oxygen Species / Q000378:metabolism; D012127:Respiratory Distress Syndrome, Newborn / Q000097:blood / Q000378:metabolism*; D013396:Suction; D014132:Trachea / Q000378:metabolism*; D014527:Uric Acid / Q000097:blood / Q000378:metabolism*
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D005609:Free Radicals; D017382:Reactive Oxygen Species; D014527:Uric Acid; D001205:Ascorbic Acid