Patterns of meiotic variability of the (CAG)n repeat in the Huntington disease gene.
We have collected 76 parent-offspring (CAG)n values in 60 French Huntington's disease (HD) pedigrees. The analysis of intergenerational alterations in CAG repeat length shows that there is a correlation between repeat instability and parental repeat length. Paternally inherited cases are characterized by a preferential trend towards an increase in range of repeat sizes in offspring of HD patients.
Lucotte
G
G
Center of Neurogenetics, CHU of Reims, France.
Gérard
N
N
Aouizérate
A
A
Loirat
F
F
Hazout
S
S
D000328:Adult; D004247:DNA / Q000235:genetics; D005260:Female; D005819:Genetic Markers / Q000235:genetics; D005820:Genetic Testing; D014644:Genetic Variation; D006801:Humans; D000071058:Huntingtin Protein; D006816:Huntington Disease / Q000175:diagnosis / Q000235:genetics*; D008297:Male; D008540:Meiosis / Q000235:genetics*; D009419:Nerve Tissue Proteins / Q000235:genetics*; D009687:Nuclear Proteins / Q000235:genetics*; D012091:Repetitive Sequences, Nucleic Acid; D018911:Trinucleotide Repeats / Q000235:genetics*
D005819:Genetic Markers; C086055:HTT protein, human; D000071058:Huntingtin Protein; D009419:Nerve Tissue Proteins; D009687:Nuclear Proteins; D004247:DNA