Neuronal laminins and their cellular receptors.
The laminins are a family of extracellular matrix glycoproteins expressed throughout developing neural tissues. The laminins are potent stimulators of neurite outgrowth in vitro for a variety of cell types, presumably reflecting an in vivo role in stimulating axon outgrowth. In recent years, the laminins have been shown to occur in several distinct isoforms; currently, the precise functional differences between the laminin variants are not well understood. A variety of neuronal surface receptors have been identified for one laminin isoform, laminin-1. These receptors include several members of the integrin family, as well as non-integrin laminin-binding proteins such as LBP-110, the 67 kDa laminin-receptor, alpha-dystroglycan, and beta 1,4 galactosyltransferase. Little is currently known about receptors for other laminin isoforms.
Powell
S K
SK
National Institute of Dental Research, national Institute of Health, Bethesda, MD 20892, USA.
Kleinman
H K
HK
D000818:Animals; D005786:Gene Expression Regulation; D006801:Humans; D016023:Integrins / Q000378:metabolism; D007536:Isomerism; D007797:Laminin / Q000502:physiology*; D009410:Nerve Degeneration; D016501:Neurites / Q000502:physiology; D009474:Neurons / Q000737:chemistry / Q000502:physiology*; D017474:Receptors, Laminin / Q000502:physiology*; D014018:Tissue Distribution
D016023:Integrins; D007797:Laminin; D017474:Receptors, Laminin