Does the in-vitro efficiency of meso-tetrahydroxy-phenyl-chlorin depend on pre-treatment of sensitizer?
The efficiency of a new photosensitizer of the second generation, meso-tetra-hydroxyphenyl-chlorin (mTHPC), which has a strong absorption at 652 nm, was investigated by oxygen consumption measurements and membrane integrity testing. The experiments proved a great increase in the efficiency of mTHPC after preincubation at 37 degrees C for 24 hours. From these findings it can be assumed that tumor cells can be treated in an optimal way with PDT after a longer delay following drug administration.
Fiedler
D M
DM
Department of Physics and Biophysics, University of Salzburg, Austria.
Wierrani
F
F
Schnitzhofer
G
G
Stewart
J C
JC
Gharehbaghi
K
K
Grünberger
W
W
Krammer
B
B
D002460:Cell Line; D002462:Cell Membrane / Q000187:drug effects; D005347:Fibroblasts / Q000187:drug effects / Q000378:metabolism; D006415:Hematoporphyrins; D006801:Humans; D008652:Mesoporphyrins / Q000494:pharmacology*; D008858:Microscopy, Phase-Contrast; D010101:Oxygen Consumption / Q000187:drug effects; D017319:Photosensitizing Agents / Q000494:pharmacology*
D006415:Hematoporphyrins; D008652:Mesoporphyrins; D017319:Photosensitizing Agents; C071875:photosan III; C072269:temoporfin