The effect of inhaled salbutamol and salmeterol on lung function and endurance performance in healthy well-trained athletes.
The present randomized, double-blind placebo-controlled study aimed at investigating the possible improvement in endurance performance caused by inhaled salmeterol (long-acting beta 2-agonist) and salbutamol (short-acting) compared to placebo in 18 healthy well-trained athletes, aged 17-30 years old. Lung function (flow-volume loops) was measured before and after each inhaled study drug and after run to exhaustion. After inhalation of study drug and 10 min warm-up, anaerobic threshold was measured; thereafter maximum oxygen uptake, peak ventilation and running time until exhaustion during a brief graded exercise were measured. No significant differences were found for ventilation, oxygen uptake or heart rate at anaerobic threshold or at maximum performance between placebo and the beta 2-agonists. Lung function increased significantly after exercise, but without differences between the beta 2-agonists and placebo. Running time till exhaustion was significantly reduced after both the long- and the short-acting beta 2-agonist compared to the placebo.
Carlsen
K H
KH
Norwegian University of Sports and Physical Education, Oslo, Norway.
Ingjer
F
F
Kirkegaard
H
H
Thyness
B
B
D000280:Administration, Inhalation; D000293:Adolescent; D000318:Adrenergic beta-Agonists / Q000008:administration & dosage*; D000328:Adult; D000420:Albuterol / Q000008:administration & dosage* / Q000031:analogs & derivatives*; D018592:Cross-Over Studies; D004311:Double-Blind Method; D005080:Exercise Test; D006801:Humans; D008168:Lung / Q000187:drug effects / Q000502:physiology*; D008297:Male; D010101:Oxygen Consumption; D010807:Physical Endurance / Q000187:drug effects*; D010809:Physical Fitness / Q000502:physiology*; D012123:Pulmonary Ventilation / Q000187:drug effects; D012420:Running / Q000502:physiology; D000068299:Salmeterol Xinafoate
D000318:Adrenergic beta-Agonists; D000068299:Salmeterol Xinafoate; D000420:Albuterol