title: Bovine rotavirus strain 678 possesses VP4 of serotype P7[5] specificity.
abstract: Bovine rotavirus strain 678 is the first G8 strain of bovine origin but the literature is confusing as to its P type. In this study, two-way cross neutralization between 678 and 0510, a prototype G6P7[5] virus, was shown by plaque-reduction neutralization assays, establishing the P type of 678 as being P7[5]. The P7[5] specificity of 678 VP4 was reinforced by the finding that the VP8* portion of 678 VP4 had the highest amino acid identity with those of P7[5] bovine rotaviruses. Apparent contradiction with previous serological studies relates to intricacy of antigenicity and immunogenicity of UK VP4 in reassortants.
authors.affiliation: Department of Microbiology, Akita University School of Medicine, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Nakagomi
authors.forename: O
authors.initials: O
authors.lastname: Nakagomi
authors.forename: H J
authors.initials: HJ
authors.lastname: Streckert
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002213:Capsid / Q000145:classification* / Q000235:genetics; D036022:Capsid Proteins; D002417:Cattle; D004279:DNA, Viral; D006168:Guinea Pigs; D008969:Molecular Sequence Data; D009500:Neutralization Tests; D012401:Rotavirus / Q000145:classification* / Q000235:genetics; D017386:Sequence Homology, Amino Acid; D012703:Serotyping
chemical_list: D036022:Capsid Proteins; D004279:DNA, Viral; C060339:VP4 protein, Rotavirus