[Reversible increase in photosensitivity to UV-B caused by St. John's wort extract].
A 61-year-old woman with depression developed recurring elevated itching erythematous lesions in light-exposed areas after taking St. John's Wort-extract for three years. Routine patchtesting did not reveal any relevant reactions and photopatch testing was negative. Using a systemic oral photoprovocation test with St. John's Wort, we were able to demonstrate a decrease of the MED-UVB which was reversible after withdrawal of the medication.
Golsch
S
S
Dermatologische Klinik und Poliklinik am Biederstein, Technische Universität, München.
Vocks
E
E
Rakoski
J
J
Brockow
K
K
Ring
J
J
D000928:Antidepressive Agents / Q000008:administration & dosage / Q000009:adverse effects*; D003866:Depressive Disorder / Q000188:drug therapy; D017454:Dermatitis, Photoallergic / Q000209:etiology*; D003875:Drug Eruptions / Q000209:etiology*; D005260:Female; D006801:Humans; D020902:Hypericum; D008875:Middle Aged; D010328:Patch Tests; D010569:Perylene / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D010946:Plants, Medicinal; D011794:Quercetin / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D014466:Ultraviolet Rays / Q000009:adverse effects*; D014966:Xanthenes / Q000008:administration & dosage / Q000009:adverse effects*
D000928:Antidepressive Agents; D014966:Xanthenes; D010569:Perylene; D011794:Quercetin