title: [A double column double pH solid phase extraction and capillary GC/FID method for rapid simultaneous determination of acidic and basic drugs in human plasma].
abstract: A capillary gas chromatographic method for the rapid simultaneous identification and quantitation of acidic and basic drugs in human plasma is presented. A special double column solid phase extraction device was designed, in which two X-5 resin columns can extract drugs at different pH. The detection limits for acidic and basic drugs can reach 0.5 microgram.ml-1, while the time needed is only half of that when using commercial solid phase extraction cartridges.
authors.affiliation: Institute of Toxicology and Pharmacology, Academy of Military Medical Sciences, Beijing.
authors.forename: F H
authors.initials: FH
authors.lastname: Qiu
authors.forename: L
authors.initials: L
authors.lastname: Liu
authors.forename: Y
authors.initials: Y
authors.lastname: Luo
authors.forename: Y Q
authors.initials: YQ
authors.lastname: Lu
mesh_terms: D000779:Anesthetics, Local / Q000097:blood; D014150:Antipsychotic Agents / Q000097:blood*; D002849:Chromatography, Gas / Q000379:methods; D003975:Diazepam / Q000097:blood; D006801:Humans; D006993:Hypnotics and Sedatives / Q000097:blood*; D008012:Lidocaine / Q000097:blood; D010640:Phenothiazines; D012631:Secobarbital / Q000097:blood*
chemical_list: D000779:Anesthetics, Local; D014150:Antipsychotic Agents; D006993:Hypnotics and Sedatives; D010640:Phenothiazines; D012631:Secobarbital; D008012:Lidocaine; D003975:Diazepam