[The effect of calcium gluconate on the acute and chronic toxicity of doxorubicin in mice].
The effect of calcium gluconate on the toxicity of the anthracycline antibiotic doxorubicin (DOX) in mice was studied. Calcium gluconate showed a significant protective action with respect to the DOX acute toxicity. When DOX was used in the lethal doses, up to the LD50s calcium gluconate protected all the mice from death. At the DOX LD100 or higher the antitoxic effect of calcium gluconate manifested itself in a lower death rate and/or in a higher lifespan of the animals (at least 2-fold). When DOX was used for the treatment course its chronic toxicity in the presence of calcium gluconate was 2 or more times lower by all the quantitative indices: the lifespan of the animals that died, the maximum and minimum total lethal doses of DOX, the latent period before the first mouse death, the overall duration of the DOX treatment course. The antitoxic effect of calcium gluconate also manifested itself in a lower DOX acute and chronic toxicity with respect to the gastrointestinal tract. Thus, calcium gluconate proved to be an effective DOX antitoxic modificator which provided the use of about 2 times higher single and courses doses of DOX in mice.
Bogush
T A
TA
Smirnova
G V
GV
Vikhliantseva
N O
NO
Syrkin
A B
AB
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000633:toxicity*; D001835:Body Weight / Q000187:drug effects; D002125:Calcium Gluconate / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004317:Doxorubicin / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000633:toxicity*; D004347:Drug Interactions; D007928:Lethal Dose 50; D051379:Mice; D008808:Mice, Inbred CBA; D013997:Time Factors
D000903:Antibiotics, Antineoplastic; D004317:Doxorubicin; D002125:Calcium Gluconate