title: Simvastatin-induced myopathy in a patient treated for hypercholesterolemia. Morphological aspects.
abstract: Functional and histological changes in skeletal muscle developing during hypolipemic therapy, especially with 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors are rare. This paper reports a case of simvastatin-induced myopathy confirmed histopathologically and ultrastructurally.
authors.affiliation: Department of Clinical and Experimental Pathomorphology, Jagiellonian University Medical College, Kraków.
authors.forename: E
authors.initials: E
authors.lastname: Wicher-Muniak
authors.forename: K
authors.initials: K
authors.lastname: Zmudka
authors.forename: W
authors.initials: W
authors.lastname: Dabroś
authors.forename: D
authors.initials: D
authors.lastname: Dudek
authors.forename: J
authors.initials: J
authors.lastname: Stachura
mesh_terms: D006801:Humans; D006937:Hypercholesterolemia / Q000188:drug therapy*; D008148:Lovastatin / Q000009:adverse effects / Q000031:analogs & derivatives*; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000187:drug effects / Q000473:pathology / Q000648:ultrastructure; D009135:Muscular Diseases / Q000139:chemically induced* / Q000473:pathology*; D019821:Simvastatin
chemical_list: D008148:Lovastatin; D019821:Simvastatin