title: Opportunistic infections in pediatric HIV infection: a study of 74 autopsy cases from Latin America. The Latin American AIDS Pathology Study Group.
abstract: The present report describes opportunistic infections found at 74 autopsies of pediatric HIV/AIDS patients performed at several hospitals in Latin American countries. Fungal infections were the most common (53 cases), Candida sp. (39.18%) and Pneumocystis carinii (20.27%) being the most frequently recognized. Other fungal diseases included histoplasmosis, aspergillosis, and cryptococcosis. Viral infections were present in 31 cases, 38.7% being due to cytomegalovirus. Other viruses recognized included herpes simplex and adenovirus. Additional opportunistic infections were due to Mycobacterium avium-intracellulare, toxoplasmosis, and tuberculosis. Nonspecific bacterial bronchopneumonia was present in 11 cases. Cytomegalovirus and P. carinii coinfection was the most common association found. In this series patients died at a younger age (72% at or younger than 1 year old) and there was a slightly higher number of cases of histoplasmosis and brain toxoplasmosis than in other previously published series of infants and children.
authors.affiliation: Servicio de Patologia, Hospital de Niños, La Plata, Argentina.
authors.forename: R
authors.initials: R
authors.lastname: Drut
authors.forename: V
authors.initials: V
authors.lastname: Anderson
authors.forename: M A
authors.initials: MA
authors.lastname: Greco
authors.forename: C
authors.initials: C
authors.lastname: Gutiérrez
authors.forename: B
authors.initials: B
authors.lastname: de León-Bojorge
authors.forename: D
authors.initials: D
authors.lastname: Menezes
authors.forename: A
authors.initials: A
authors.lastname: Peruga
authors.forename: G
authors.initials: G
authors.lastname: Quijano
authors.forename: C
authors.initials: C
authors.lastname: Ridaura
authors.forename: M
authors.initials: M
authors.lastname: Siminovich
authors.forename: P V
authors.initials: PV
authors.lastname: Mayoral
authors.forename: M
authors.initials: M
authors.lastname: Weissenbacher
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000453:epidemiology / Q000473:pathology*; D000293:Adolescent; D000818:Animals; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007843:Latin America / Q000453:epidemiology; D008297:Male