[Isoprostanes, a new substance group in angiology--of future significance?].
F2-isoprostanes are prostaglandin F2-like compounds being formed by non-enzymatic peroxidation of arachidonic acid in vivo. They have a variety of biological actions. The most important compound of this group is 8-epi-PGF(2 alpha) being capable to induce vasconstriction in particular of lung- and renal vascular tissue. Isoprostanes are present in esterified form; in free form they become available after hydrolysis by phospholipase A. An increase in isoprostanes is an important indicator of oxidative stress in-vivo due to a variety of different noxi such as metal- or non-metal ions for cigarette smoke. Isoprostanes show an activation of platelets; as a consequence of the interaction of 8-epi-PGF(2 alpha) with specific receptors platelet aggregation may be induced or may be enhanced together with other agonists. Due to these preliminary results isoprostanes could become an interesting substance in angiology in the future for diagnosis of oxidative stress as well as in the understanding of the pathogenesis of atherosclerosis.
Aghajanian
A A
AA
Wilhelm Auerswald Atheroskleroseforschungsgruppe, Wien.
Oguogho
A
A
Sinzinger
H
H
D000818:Animals; D001161:Arteriosclerosis / Q000503:physiopathology*; D015237:Dinoprost / Q000031:analogs & derivatives* / Q000502:physiology; D006801:Humans; D015227:Lipid Peroxidation; D010974:Platelet Aggregation / Q000502:physiology*; D014661:Vasoconstriction / Q000502:physiology*
C075750:8-epi-prostaglandin F2alpha; D015237:Dinoprost