title: The use of capillary electrophoresis as part of a specificity testing strategy for mitoguazone dihydrochloride HPLC methods.
abstract: Capillary electrophoresis (CE) has been used as part of a validation experiment designed to prove the specificity of high performance liquid chromatography (HPLC) methods used for analysis of mitoguazone dihydrochloride drug substance. Data regarding accuracy, precision and sensitivity of the CE methods are presented as well as a comparison of results obtained from CE, HPLC and thin-layer chromatography (TLC) analysis of samples stressed under a variety of conditions. It was concluded that, not only were the HPLC methods being investigated specific, but that CE could potentially be used to replace HPLC for the routine assay of mitoguazone dihydrochloride.
authors.affiliation: Sanofi Research, Alnwick, Northumberland, UK.
authors.forename: C E
authors.initials: CE
authors.lastname: Thomson
authors.forename: M R
authors.initials: MR
authors.lastname: Gray
authors.forename: M P
authors.initials: MP
authors.lastname: Baxter
mesh_terms: D000970:Antineoplastic Agents / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D019075:Electrophoresis, Capillary; D008935:Mitoguazone / Q000032:analysis*; D015203:Reproducibility of Results
chemical_list: D000970:Antineoplastic Agents; D008935:Mitoguazone