Homoserine O-acetyltransferase, involved in the Leptospira meyeri methionine biosynthetic pathway, is not feedback inhibited.
The Leptospira meyeri serovar semaranga metX gene was identified by complementation of an Escherichia coli metA mutant, i.e., devoid of homoserine O-succinyltransferase. However, the MetX protein exhibited a homoserine O-acetyltransferase activity in agreement with its similarity to homoserine O-acetyltransferases. Reverse transcription-PCR analysis demonstrated that metX is the second gene of an operon.
Bourhy
P
P
Unité de Bacteriologie Moleculaire et Mf1edicale, Institut Pasteur, Paris, France.
Martel
A
A
Margarita
D
D
Saint Girons
I
I
Belfaiza
J
J
D000123:Acetyltransferases / Q000235:genetics* / Q000378:metabolism; D000217:Acyltransferases / Q000235:genetics; D000595:Amino Acid Sequence; D001426:Bacterial Proteins / Q000235:genetics* / Q000378:metabolism; D001483:Base Sequence; D003001:Cloning, Molecular; D004269:DNA, Bacterial; D005816:Genetic Complementation Test; D051082:Homoserine O-Succinyltransferase; D007919:Leptospira / Q000201:enzymology* / Q000235:genetics; D008715:Methionine / Q000096:biosynthesis*; D008969:Molecular Sequence Data; D009876:Operon; D017386:Sequence Homology, Amino Acid
D001426:Bacterial Proteins; D004269:DNA, Bacterial; D008715:Methionine; D000217:Acyltransferases; D000123:Acetyltransferases; C021369:homoserine O-acetyltransferase; D051082:Homoserine O-Succinyltransferase