Effect of DV-7028, a novel serotonin 5-HT2 receptor antagonist on the cardiovascular system in rats.
The response of the cardiovascular system to DV-7028 demonstrated the complex action of this substance. In anaesthetized rats DV-7028 decreased the blood pressure and heart rate. These effects did not occur in pithed rats. The hypotensive action and bradycardia was partially reduced in vagotomized animals. DV-7028 potently inhibited the vasoconstrictory effects of serotonin in isolated perfused hindlegs of rat and caused a concentration-dependent shift to the right of response curve to serotonin in the rat tail artery. The present data demonstrate that DV-7028 is a potent 5-HT2 receptor antagonist. Besides its peripheral action, DV-7028 exerts central effects which cause hypotension and bradycardia.
Pawlak
D
D
Department of Pharmacodynamics, Medical Academy, Białystok, Poland.
Małyszko
J
J
Myśliwiec
M
M
Takada
A
A
Buczko
W
W
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001808:Blood Vessels / Q000187:drug effects; D002319:Cardiovascular System / Q000187:drug effects*; D003655:Decerebrate State; D006339:Heart Rate / Q000187:drug effects; D006614:Hindlimb / Q000098:blood supply; D066298:In Vitro Techniques; D010880:Piperidines / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012701:Serotonin / Q000494:pharmacology; D012702:Serotonin Antagonists / Q000494:pharmacology*; D013623:Tail / Q000098:blood supply; D014227:Triazines / Q000494:pharmacology*; D014628:Vagotomy; D014662:Vasoconstrictor Agents / Q000494:pharmacology
D010880:Piperidines; D012702:Serotonin Antagonists; D014227:Triazines; D014662:Vasoconstrictor Agents; C073727:DV 7028; D012701:Serotonin