title: A newly developed silicone-coated membrane oxygenator for long-term cardiopulmonary bypass and cardiac support.
abstract: The surface of polypropylene hollow fiber was successfully coated with a very thin (0.2 micron) silicone layer. Experimental studies were performed in long-term (6 h) normothermic cardiopulmonary bypass (CPB) using 10 goats. A conventional membrane oxygenator (Mera Excelung HPO-15H, MERA, Tokyo, Japan) was used for 5 goats as a control (Group C) and a new silicone-coated membrane oxygenator, which is of the same construction as that of the one used for Group C, for 5 (Group S). The O2 transfer and CO2 removal functions showed the same ranges. In the other parameters, there were no differences between the 2 groups. As for hemolysis, however, the plasma free hemoglobin of Group S was lower than that of Group C. Currently, 3 chronic percutaneous cardiopulmonary support (PCPS) experimental models have been conducted, and there has been no evidence of thromboembolism or deterioration of the oxygenator. In conclusion, this new oxygenator is suitable not only for CPB, but also for long-term cardiac support.
authors.affiliation: Second Department of Surgery, Nihon University School of Medicine, Tokyo, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Iida
authors.forename: M
authors.initials: M
authors.lastname: Shiono
authors.forename: Y
authors.initials: Y
authors.lastname: Orime
authors.forename: K
authors.initials: K
authors.lastname: Nakata
authors.forename: M
authors.initials: M
authors.lastname: Hata
authors.forename: A
authors.initials: A
authors.lastname: Sezai
authors.forename: H
authors.initials: H
authors.lastname: Yamada
authors.forename: S
authors.initials: S
authors.lastname: Kashiwazaki
authors.forename: M
authors.initials: M
authors.lastname: Nemoto
authors.forename: J
authors.initials: J
authors.lastname: Kinoshita
authors.forename: Y
authors.initials: Y
authors.lastname: Sezai
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000378:metabolism*; D001784:Blood Gas Analysis; D002245:Carbon Dioxide / Q000378:metabolism; D002315:Cardiopulmonary Bypass / Q000009:adverse effects / Q000592:standards*; D006041:Goats; D006353:Heart-Assist Devices / Q000009:adverse effects / Q000592:standards*; D006454:Hemoglobins / Q000378:metabolism; D006461:Hemolysis; D010101:Oxygen Consumption / Q000502:physiology; D010107:Oxygenators, Membrane / Q000009:adverse effects / Q000592:standards*; D011126:Polypropylenes / Q000378:metabolism; D011659:Pulmonary Gas Exchange; D012015:Reference Standards; D012121:Respiration, Artificial; D012828:Silicones
chemical_list: D001672:Biocompatible Materials; D006454:Hemoglobins; D011126:Polypropylenes; D012828:Silicones; D002245:Carbon Dioxide