title: Delayed CT of the kidneys after iopentol (Imagopaque 350) injection in patients with normal renal function. An assessment of the gradual decrease in opacification over 32 h after injection.
abstract: The elimination of the non-ionic contrast medium iopentol (Imagopaque, Nycomed Imaging AS, Oslo, Norway) from the kidneys was investigated in adult patients with normal renal function referred for cerebral computed tomography (CT). Twenty-four patients were included in the study. Each patient was given one intravenous injection of 50 ml iopentol 350 mg I/ml. CT scans of the kidneys were taken before, immediately after, 8 h after and 32 h after the injection of contrast medium. To assess the rate of iopentol disappearance, calculations were made for the cortex, medulla and aorta, based on changes from the baseline (pre-contrast) measurements, in Hounsfield units (HU). The median estimated time for disappearance was 28 h from the cortex, 32 h from the medulla and 8 h from the aorta. Thus, a small retention of contrast medium can usually be seen after normalization of aortic HU values.
authors.affiliation: Department of Diagnostic Radiology, Middlesex Hospital, London, UK.
authors.forename: D
authors.initials: D
authors.lastname: Rickards
authors.forename: J A
authors.initials: JA
authors.lastname: Jakobsen
authors.forename: A J
authors.initials: AJ
authors.lastname: Klaveness
authors.forename: P
authors.initials: P
authors.lastname: Kjaersgaard
mesh_terms: D001921:Brain / Q000000981:diagnostic imaging; D003287:Contrast Media / Q000009:adverse effects / Q000493:pharmacokinetics; D005260:Female; D006801:Humans; D007668:Kidney / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D014283:Triiodobenzoic Acids / Q000009:adverse effects / Q000493:pharmacokinetics
chemical_list: D003287:Contrast Media; D014283:Triiodobenzoic Acids; C053571:iopentol