Neuromuscular blocking actions of the aminoglycoside antibiotics sisomicin and micronomicin in the rabbit.
The neuromuscular blocking actions of sisomicin sulfate (SISO), micronomicin sulfate (MCR) and d-tubocurarine (dTc) were studied in 20 rabbits anesthetized with halothane. The i.v. administration of SISO 20-40 mg/kg, MCR 40-80 mg/kg or dTc 0.1-0.3 mg/kg resulted in dose-dependent decreases in twitch tension. The ED50s for SISO, MCR and dTc were 23.5, 58.2 and 0.2 mg/kg, respectively. SISO- and MCR-induced neuromuscular blockade was partially antagonized by neostigmine or by calcium.
Matsukawa
S
S
Division of Intensive Care Medicine, Tohoku University Hospital, Japan.
Suh
J H
JH
Hashimoto
Y
Y
Kato
M
M
Satoh
D
D
Saito
S
S
Endo
K
K
Saishu
T
T
D000617:Aminoglycosides; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D002118:Calcium / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005839:Gentamicins; D009119:Muscle Contraction / Q000187:drug effects; D009388:Neostigmine / Q000494:pharmacology; D009466:Neuromuscular Blocking Agents / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D011817:Rabbits; D012853:Sisomicin / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D014403:Tubocurarine / Q000008:administration & dosage / Q000494:pharmacology
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D005839:Gentamicins; D009466:Neuromuscular Blocking Agents; D009388:Neostigmine; C037545:micronomicin; D002118:Calcium; D014403:Tubocurarine; D012853:Sisomicin