title: The conformation of ribosomes and rRNA.
abstract: During the past 18 months, electron microscopists have published two reconstructions of the Escherichia coli ribosome, independently derived from images of unstained particles. The resolutions of their images are 20-25 A-much higher than any previously available. During the same time, NMR spectroscopists have provided an atomic-resolution model for the A-site region of 16S rRNA complexed with paromomycin that explains much of what is known about the interaction of aminoglycoside antibiotics with ribosomes.
authors.affiliation: Department of Chemistry, Yale University, New Haven, CT 06511, USA.
authors.forename: P B
authors.initials: PB
authors.lastname: Moore
mesh_terms: D008854:Microscopy, Electron / Q000379:methods; D008954:Models, Biological; D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D010303:Paromomycin / Q000737:chemistry / Q000378:metabolism; D012335:RNA, Ribosomal / Q000737:chemistry* / Q000378:metabolism*; D012336:RNA, Ribosomal, 16S / Q000737:chemistry / Q000378:metabolism; D012270:Ribosomes / Q000737:chemistry* / Q000378:metabolism*
chemical_list: D012335:RNA, Ribosomal; D012336:RNA, Ribosomal, 16S; D010303:Paromomycin