Z1046: a new specific peripheral dopaminergic compound.
It is well established that peripheral dopamine receptors activation evokes vasodilation and neurohormonal modulation. Z1046 is a potent mixed dopaminergic agonist and is highly selective over adrenergic and serotoninergic (5-HT2) activities. In contrast, dopamine had agonist activities on all adrenergic receptors while it is known that dopexamine has a beta 2 agonist activity and is an inhibitor of the neuronal uptake. As far as fenoldopam is concerned, selective stimulation of D1-like receptors leads to an increase of renin release. In conclusion, Z1046 is a potent and specific drug for dopamine receptors. This profile makes Z1046 different from other dopaminergic agents.
Ferlenga
P
P
Zambon Group, Bresso, Milan, Italy.
Zanzottera
D
D
Biasini
I
I
Marchini
F
F
Semeraro
C
C
D000818:Animals; D001158:Arteries / Q000187:drug effects; D004298:Dopamine / Q000031:analogs & derivatives / Q000494:pharmacology; D018491:Dopamine Agonists / Q000494:pharmacology*; D018492:Dopamine Antagonists / Q000494:pharmacology; D004423:Ear / Q000098:blood supply; D018818:Fenoldopam / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D009284:Naphthols / Q000494:pharmacology*; D011817:Rabbits; D013154:Spleen / Q000098:blood supply
D018491:Dopamine Agonists; D018492:Dopamine Antagonists; D009284:Naphthols; C105333:Z1046; C046318:dopexamine; D018818:Fenoldopam; D004298:Dopamine