title: [Buspirone--a wide-spectrum preparation].
abstract: It has been demonstrated on albino rats that buspirone produces an antidepressive and nootropic-like effect in small doses (0.5-1.0 mg/kg) and an anxiolytic, cataleptogenic, and neuroleptic-like effect in high doses (5.0-10.0 mg/kg). The wide spectrum of its activity is due to the presence of various mediator components, serotonin- and dopaminergic in particular, in the mechanism of its action.
authors.forename: G M
authors.initials: GM
authors.lastname: Molodavkin
authors.forename: T A
authors.initials: TA
authors.lastname: Voronina
mesh_terms: D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001569:Benzodiazepines; D001570:Benzodiazepinones / Q000494:pharmacology; D002065:Buspirone / Q000494:pharmacology*; D002375:Catalepsy / Q000139:chemically induced; D003220:Conflict, Psychological; D004305:Dose-Response Relationship, Drug; D005073:Evoked Potentials, Somatosensory / Q000187:drug effects; D008297:Male; D005082:Physical Exertion / Q000187:drug effects; D011817:Rabbits; D051381:Rats; D017366:Serotonin Receptor Agonists / Q000494:pharmacology*; D013550:Swimming
chemical_list: D014151:Anti-Anxiety Agents; D001570:Benzodiazepinones; D017366:Serotonin Receptor Agonists; D001569:Benzodiazepines; C017928:phenazepam; D002065:Buspirone