title: Thy-1 expression on blast cells from adult patients with acute myeloid leukemia.
abstract: Bone marrow and peripheral blood from 28 adult patients with acute myeloid leukemia (AML) were analyzed for the surface expression of the Thy-1 antigen by dual-colour flow cytometry. The Thy-1 antigen was expressed on greater than 5% of cells from seven patients with the proportions of Thy-1 positive cells ranging from 8.1% to 85.0%. The CD34+ Thy-1+ phenotype was present in all seven cases. The expression of Thy-1 on leukemia cells from patients with AML may need to be considered in the development of methods of normal stem cell isolation from these patients.
authors.affiliation: Division of Hematology/Bone Marrow Transplantation, University of Pittsburgh Medical Center, PA 15213, USA.
authors.forename: R
authors.initials: R
authors.lastname: Kozii
authors.forename: J
authors.initials: J
authors.lastname: Wilson
authors.forename: J
authors.initials: J
authors.lastname: Persichetti
authors.forename: V
authors.initials: V
authors.lastname: Phelps
authors.forename: S E
authors.initials: SE
authors.lastname: Ball
authors.forename: E D
authors.initials: ED
authors.lastname: Ball
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D015703:Antigens, CD / Q000032:analysis; D018952:Antigens, CD34 / Q000032:analysis; D001752:Blast Crisis; D001853:Bone Marrow / Q000276:immunology / Q000473:pathology; D002869:Chromosome Aberrations; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D007621:Karyotyping; D007951:Leukemia, Myeloid / Q000097:blood / Q000235:genetics / Q000276:immunology* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D018800:Thy-1 Antigens / Q000032:analysis* / Q000097:blood
chemical_list: D015703:Antigens, CD; D018952:Antigens, CD34; D018800:Thy-1 Antigens