RNA editing: rewriting receptors.
The type of RNA editing that converts adenosine to inosine in double-stranded RNA generates different isoforms of subunits of the ionotropic glutamate-gated ion channel receptors. Recently, it has been reported that the pre-mRNA of the serotonin 2C receptor can be edited by the same mechanism.
O'Connell
M A
MA
Department of Cell Biology, Biozentrum of the University of Basel, Klingelberstrasse 70, CH-4056, Basel, Switzerland. oconnell@ubaclu.unibas.ch
D000243:Adenosine Deaminase / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D006801:Humans; D017393:RNA Editing; D012322:RNA Precursors; D016601:RNA-Binding Proteins; D044405:Receptor, Serotonin, 5-HT2C; D011985:Receptors, Serotonin / Q000235:genetics*
D012322:RNA Precursors; D016601:RNA-Binding Proteins; D044405:Receptor, Serotonin, 5-HT2C; D011985:Receptors, Serotonin; C567955:ADARB1 protein, human; D000243:Adenosine Deaminase