The quest for migraine genes.
Research into the genetics of migraine remains difficult because of the involvement of polygenetic and environmental factors. The discovery of the gene for familial hemiplegic migraine on chromosome 19p 13 is an important step forward. This brain specific P/Q-type calcium channel alpha 1-subunit gene opens new avenues for studying the genetics of migraine, the pathophysiology of the onset of migraine attacks and the development of novel specific prophylactic drugs.
Terwindt
G M
GM
Department of Neurology, Leiden University Medical Centre, The Netherlands.
Haan
J
J
Ophoff
R A
RA
Frants
R R
RR
Ferrari
M D
MD
D005192:Family Health; D006801:Humans; D008881:Migraine Disorders / Q000235:genetics*