A rat model of spontaneously arrested hydrocephalus. A behavioural study.
HTX rats with congenital hydrocephalus that survived for more than 2 months are termed spontaneously arrested hydrocephalic rats. These rats showed impairment in learning, a reverse light-dark discrimination task in a Y-maze. A clear relationship between learning impairment and ventricular dilatation was observed in spontaneously arrested hydrocephalic animals. The usefulness and limitations of HTX-rats as an animal model of spontaneously arrested hydrocephalus are discussed.
Miyazawa
T
T
Department of Neurosurgery, Juntendo University School of Medicine, Tokyo, Japan.
Sato
K
K
Ikeda
Y
Y
Nakamura
N
N
Matsumoto
K
K
D000818:Animals; D001284:Atrophy; D001522:Behavior, Animal / Q000502:physiology*; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000473:pathology / Q000503:physiopathology; D002552:Cerebral Ventricles / Q000473:pathology / Q000503:physiopathology; D004195:Disease Models, Animal; D006849:Hydrocephalus / Q000473:pathology / Q000503:physiopathology*; D008297:Male; D018782:Maze Learning / Q000502:physiology; D011939:Mental Recall / Q000502:physiology; D009043:Motor Activity / Q000502:physiology; D051381:Rats; D012193:Reversal Learning / Q000502:physiology; D014796:Visual Perception / Q000502:physiology