Effects of interleukin-10 on water intake, locomotory activity, and rectal temperature in rat treated with endotoxin.
Intracerebroventricular (i.c.v.) interleukin-10 (25, 50, and 100 ng/rat) effects on water intake, exploratory behaviour, and rectal temperature were evaluated in rats treated intraperitoneally (i.p.) with lipopolysaccharide (0.32, 0.64, and 0.96 mg/kg). Endotoxin administration induced fever and inhibition of thirst in water-deprived rats, and a decrease in lococomotory activity in normohydrated and water-deprived animals. Our data show that interleukin-10 during lipopolysaccharide administration controlled fever, increases exploratory behaviour, but did not reverse lipopolysaccharide inhibition of thirst. These effects suggest that fever, depression in locomotory activity but not inhibition of thirst, induced by endotoxin are influenced by interleukin-10 levels.
Nava
F
F
Institute of Pharmacology, School of Medicine, University of Messina, Italy.
Calapai
G
G
Facciolá
G
G
Cuzzocrea
S
S
Marciano
M C
MC
De Sarro
A
A
Caputi
A P
AP
D000818:Animals; D001831:Body Temperature / Q000187:drug effects*; D004731:Endotoxins / Q000494:pharmacology* / Q000633:toxicity; D005106:Exploratory Behavior / Q000187:drug effects*; D005334:Fever / Q000139:chemically induced / Q000503:physiopathology; D007276:Injections, Intraventricular; D016753:Interleukin-10 / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology*; D008070:Lipopolysaccharides / Q000494:pharmacology* / Q000633:toxicity; D008124:Locomotion / Q000187:drug effects; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D011994:Recombinant Proteins / Q000494:pharmacology; D018417:Th1 Cells / Q000187:drug effects; D018418:Th2 Cells / Q000378:metabolism; D013894:Thirst / Q000187:drug effects*
D004731:Endotoxins; D008070:Lipopolysaccharides; D011994:Recombinant Proteins; D016753:Interleukin-10; C044101:endotoxin, Escherichia coli