title: Comparison of colloidal bismuth subcitrate and metronidazole, both in combination with an H2-antagonist as therapy for Helicobacter pylori.
abstract: In this random study, the efficacy of either colloidal bismuth subcitrate (CBS) or metronidazole in combination with an H2-antagonist in the treatment of various gastric pathologies was evaluated, along with the trends in antibody levels. Among the 40 Helicobacter pylori-positive patients with various gastroduodenal pathologies who underwent chemotherapy, 27 were treated with CBS and 13 with metronidazole. H. pylori was eradicated in 48.14% of the patients treated with CBS and 53.8% of those treated with metronidazole. After therapy, no statistically significant or slight decrease in the serum levels of antibodies was found.
authors.affiliation: Institute of Toxicologic, Hygienic and Environmental Sciences, University of Urbino, Italy.
authors.forename: W
authors.initials: W
authors.lastname: Baffone
authors.forename: F
authors.initials: F
authors.lastname: Belbusti
authors.forename: E
authors.initials: E
authors.lastname: Barbieri
authors.forename: A
authors.initials: A
authors.lastname: Pianetti
authors.forename: F
authors.initials: F
authors.lastname: Bruscolini
authors.forename: M T
authors.initials: MT
authors.lastname: Fabi
authors.forename: L
authors.initials: L
authors.lastname: Salvaggio
authors.forename: A
authors.initials: A
authors.lastname: Albano
mesh_terms: D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D016481:Helicobacter Infections / Q000188:drug therapy*; D016480:Helicobacter pylori / Q000187:drug effects; D006635:Histamine H2 Antagonists / Q000627:therapeutic use*; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D008795:Metronidazole / Q000627:therapeutic use*; D008875:Middle Aged; D009942:Organometallic Compounds / Q000627:therapeutic use*
chemical_list: D000900:Anti-Bacterial Agents; D000897:Anti-Ulcer Agents; D006635:Histamine H2 Antagonists; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D009942:Organometallic Compounds; D008795:Metronidazole; C002791:bismuth tripotassium dicitrate