Ameliorating effects of SDZ ENA 713 on age-associated decreases in learning performance and brain choline acetyltransferase activity in rats.
In the present study, we have investigated the effects of SDZ ENA 713 on spatial learning deficits in aged rats. Using the same animals, the effect of SDZ ENA 713 on choline acetyltransferase was simultaneously studied to obtain a basis for the behavioral study. In the aged rats, the spatial learning and choline acetyltransferase activity in the frontal cortex were significantly deteriorated compared with young adult rats. SDZ ENA 713 (0.2 mg/kg) significantly shortened the time to reach a hidden platform without affecting swim rates in the water maze task. SDZ ENA 713 (0.1 and 0.2 mg/kg) inhibited aging-induced decreases in choline acetyltransferase activity in the frontal cortex. These results suggest that SDZ ENA 713 ameliorates aging-induced learning deficits and cholinergic dysfunction in rats.
Ohara
T
T
Sandoz Tsukuba Research Institute, Department of Pharmacology, Japan.
Fukaya
H
H
Itanaka
K
K
Seno
N
N
D000375:Aging / Q000378:metabolism / Q000523:psychology*; D000818:Animals; D015415:Biomarkers; D001921:Brain / Q000187:drug effects* / Q000201:enzymology; D002219:Carbamates / Q000494:pharmacology*; D002795:Choline O-Acetyltransferase / Q000037:antagonists & inhibitors*; D002800:Cholinesterase Inhibitors / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D007859:Learning Disabilities / Q000188:drug therapy*; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D048448:Phenylcarbamates; D051381:Rats; D011916:Rats, Inbred F344; D011976:Receptors, Muscarinic / Q000187:drug effects / Q000378:metabolism; D000068836:Rivastigmine
D015415:Biomarkers; D002219:Carbamates; D002800:Cholinesterase Inhibitors; D048448:Phenylcarbamates; D011976:Receptors, Muscarinic; D002795:Choline O-Acetyltransferase; D000068836:Rivastigmine