title: DOTATOC: a powerful new tool for receptor-mediated radionuclide therapy.
abstract: This study presents the first successful use of a peptidic vector, DOTATOC, labelled with the beta-emitting radioisotope yttrium-90, for the treatment of a patient with somatostatin receptor-positive abdominal metastases of a neuroendocrine carcinoma of unknown localization. Tumour response and symptomatic relief were achieved. In addition, the new substance DOTATOC was labelled with the diagnostic chemical analogue indium-111 and studied in three patients with histopathologically verified neuroendocrine abdominal tumours for its diagnostic sensitivity and compared with the commercially available OctreoScan. In all patients the kidney-to-tumour uptake ratio (in counts per pixel) was on average 1. 9-fold lower with 111In-DOTATOC than with OctreoScan. DOTATOC could be a potential new diagnostic and therapeutic agent in the management of neuroendocrine tumours.
authors.affiliation: Institute of Nuclear Medicine, University Hospital, School of Medicine, Basel, Switzerland.
authors.forename: A
authors.initials: A
authors.lastname: Otte
authors.forename: E
authors.initials: E
authors.lastname: Jermann
authors.forename: M
authors.initials: M
authors.lastname: Behe
authors.forename: M
authors.initials: M
authors.lastname: Goetze
authors.forename: H C
authors.initials: HC
authors.lastname: Bucher
authors.forename: H W
authors.initials: HW
authors.lastname: Roser
authors.forename: A
authors.initials: A
authors.lastname: Heppeler
authors.forename: J
authors.initials: J
authors.lastname: Mueller-Brand
authors.forename: H R
authors.initials: HR
authors.lastname: Maecke
mesh_terms: D000008:Abdominal Neoplasms / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000532:radiotherapy*; D000328:Adult; D006801:Humans; D007205:Indium Radioisotopes; D008297:Male; D008875:Middle Aged; D018358:Neuroendocrine Tumors / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000532:radiotherapy*; D015282:Octreotide / Q000031:analogs & derivatives* / Q000627:therapeutic use; D004369:Pentetic Acid / Q000031:analogs & derivatives; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000627:therapeutic use*; D017481:Receptors, Somatostatin / Q000032:analysis*; D012680:Sensitivity and Specificity; D015021:Yttrium Radioisotopes / Q000627:therapeutic use*
chemical_list: D007205:Indium Radioisotopes; D019275:Radiopharmaceuticals; D017481:Receptors, Somatostatin; D015021:Yttrium Radioisotopes; C071632:SDZ 215-811; D004369:Pentetic Acid; D015282:Octreotide; C106246:Edotreotide