title: Expression of CuZn- and Mn-superoxide dismutase in human colorectal neoplasms.
abstract: Decreased intracellular SOD protein levels and activity have been related with malignancy in the past. To investigate their relevance in the carcinogenetic process in the colon, we determined quantitatively CuZn-SOD and Mn-SOD levels and total SOD activity by histochemical means in human normal colorectal mucosa, adenomas, and carcinomas. Protein levels and activity were significantly decreased in carcinomas. CuZn-SOD protein levels, but not Mn-SOD levels or total SOD activity were related with differentiation grade and to a lesser extent with Dukes stage. Moderately differentiated carcinomas and Dukes stage A carcinomas showed lowest levels. Some carcinomas expressed elevated levels of CuZn-SOD and this was an indication of poor survival. It is concluded that decreased SOD expression is not a prognostic marker and seems to be a secondary phenomenon rather than directly linked with the carcinogenetic process.
authors.affiliation: Academic Medical Center, University of Amsterdam, Laboratory of Cell Biology and Histology, The Netherlands.
authors.forename: B E
authors.initials: BE
authors.lastname: Van Driel
authors.forename: H
authors.initials: H
authors.lastname: Lyon
authors.forename: D C
authors.initials: DC
authors.lastname: Hoogenraad
authors.forename: S
authors.initials: S
authors.lastname: Anten
authors.forename: U
authors.initials: U
authors.lastname: Hansen
authors.forename: C J
authors.initials: CJ
authors.lastname: Van Noorden
mesh_terms: D000230:Adenocarcinoma / Q000201:enzymology* / Q000473:pathology; D000236:Adenoma / Q000201:enzymology* / Q000473:pathology; D002454:Cell Differentiation; D003106:Colon / Q000201:enzymology; D015179:Colorectal Neoplasms / Q000201:enzymology* / Q000401:mortality / Q000473:pathology; D006651:Histocytochemistry; D006801:Humans; D007150:Immunohistochemistry; D007413:Intestinal Mucosa / Q000473:pathology; D008207:Lymphatic Metastasis; D009367:Neoplasm Staging; D011379:Prognosis; D012007:Rectum / Q000201:enzymology; D013482:Superoxide Dismutase / Q000378:metabolism*
chemical_list: D013482:Superoxide Dismutase