title: Pulmonary artery thrombolysis and stenting after a bilateral sequential lung transplantation.
abstract: Bilateral sequential lung transplantation was complicated by pulmonary artery anastomotic stenosis and bilateral pulmonary thromboemboli. Pulmonary artery thrombus was eliminated by intrathrombotic but not by systemic administration of urokinase. The pulmonary emboli resulted in localized pulmonary infarctions, supporting the need for thrombolytic intervention to restore pulmonary perfusion in the absence of collateral bronchial blood flow after lung transplantation. Pulmonary artery stenosis was relieved by endovascular stenting, avoiding an early reoperative procedure. This case suggests that direct administration of thrombolytic agent may be superior to intravenous administration in the treatment of pulmonary thromboemboli. Pulmonary arterial anastomotic stenoses after lung transplantation can be relieved by endovascular procedures.
authors.affiliation: Department of Cardiothoracic Surgery, Medical College of Wisconsin, Milwaukee, USA.
authors.forename: M
authors.initials: M
authors.lastname: Bousamra
authors.forename: M W
authors.initials: MW
authors.lastname: Mewissen
authors.forename: J
authors.initials: J
authors.lastname: Batter
authors.forename: K W
authors.initials: KW
authors.lastname: Presberg
authors.forename: D P
authors.initials: DP
authors.lastname: Schlueter
authors.forename: G B
authors.initials: GB
authors.lastname: Haasler
mesh_terms: D000328:Adult; D000714:Anastomosis, Surgical; D000792:Angiography; D001165:Arteriovenous Malformations / Q000000981:diagnostic imaging / Q000601:surgery; D003251:Constriction, Pathologic / Q000000981:diagnostic imaging / Q000628:therapy; D005260:Female; D006801:Humans; D016040:Lung Transplantation / Q000502:physiology*; D011183:Postoperative Complications / Q000000981:diagnostic imaging / Q000628:therapy*; D011651:Pulmonary Artery / Q000002:abnormalities / Q000000981:diagnostic imaging / Q000187:drug effects; D011655:Pulmonary Embolism / Q000000981:diagnostic imaging / Q000628:therapy*; D019233:Retreatment; D015607:Stents; D015912:Thrombolytic Therapy; D014568:Urokinase-Type Plasminogen Activator / Q000008:administration & dosage*
chemical_list: D014568:Urokinase-Type Plasminogen Activator