Modelling of gas transport function of erythrocytes in haemoglobin sorption immobilization.
Colloid-disperse systems based on haemoglobin sorption immobilization in reticular polyelectrolytes are proposed and investigated. The efficiency of oxygen transport of these systems is much higher than that of native haemoglobin and is comparable with the efficacy of gas transport of erythrocytes. This is believed to be due to highly selective sorption immobilization of haemoglobin in microdisperse forms of permeable carboxylic reticular polyelectrolytes. Microparticles exhibit high local concentration of haemoglobin, the protein mass being by one order of magnitude higher than that of the polymer carrier.
Kuznetsova
N P
NP
Institute of Macromolecular Compounds, Russian Academy of Sciences, St. Petersburg, Russia.
Mishaeva
R N
RN
Gudkin
L R
LR
Samsonov
G V
GV
D001693:Biological Transport, Active; D004912:Erythrocytes / Q000378:metabolism*; D006454:Hemoglobins / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques; D007700:Kinetics; D008863:Microspheres; D008954:Models, Biological; D010100:Oxygen / Q000097:blood*; D010108:Oxyhemoglobins / Q000378:metabolism; D011108:Polymers
D006454:Hemoglobins; D010108:Oxyhemoglobins; D011108:Polymers; D010100:Oxygen