Peptidergic innervation in human von Ebner's glands: an immunohistochemical study.
The occurrence and distribution of several neuropeptides were studied in human von Ebner's glands. Immunoreactivity for substance P, calcitonin gene-related peptide, vasoactive intestinal polypeptide (VIP), neuropeptide Y (NPY), galanin, and somatostatin was found in the nerve fibers around the acini, ducts, and blood vessels. VIP-immunoreactive varicose fibers were numerous compared with the other five neuropeptides. Most NPY fibers were associated with the vasculature in the gland. These findings suggest that the neuropeptides may regulate the secretion and vascular tone in human von Ebner's glands.
Matsuda
H
H
Department of Otorhinolaryngology, Yokohama City University School of Medicine, Kanazawa-ku, Yokohama, Japan.
Kusakabe
T
T
Kohno
H
H
Nagahara
T
T
Furukawa
M
M
Sawada
H
H
Kawakami
T
T
Takenaka
T
T
Tsukuda
M
M
D006801:Humans; D007124:Immunoenzyme Techniques; D009412:Nerve Fibers / Q000737:chemistry; D009479:Neuropeptides / Q000032:analysis*; D012469:Salivary Glands / Q000294:innervation*; D014059:Tongue / Q000033:anatomy & histology*
D009479:Neuropeptides