title: Presence of antibodies in the aqueous humour and cerebrospinal fluid during Leishmania infections in dogs. Pathological features at the central nervous system.
abstract: In the present paper we show that in dogs, naturally infected with Leishmania infantum, the aqueous humour and the cerebrospinal fluid contain anti-Leishmania IgGs and that the specificity of antigen recognition of these fluids is similar to that of the sera. We also show that in the encephalon and cerebellum of these dogs there is a pathological sponge-like reaction accompanied by neuronal degeneration, mobilization of glial cells together with accumulation of amyloid deposits. The interstitial and intravascular deposition of IgGs and Leishmania antigens in choroid plexus suggest that in these animals there is a failure of the blood-cerebrospinal and ciliary bodies filtration barriers which may allow the transfer of anti-Leishmania IgGs from the blood stream to these fluids. We suggest that the failure of the blood-cerebrospinal barrier and the in situ concentration of anti-Leishmania IgGs and antigens in brain tissues may predispose to the pathological features detected in this compartment.
authors.affiliation: Departamento de Parasitologia, Facultad de Veterinaria, Universidad de Extremadura, Caceres, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Garcia-Alonso
authors.forename: C G
authors.initials: CG
authors.lastname: Nieto
authors.forename: A
authors.initials: A
authors.lastname: Blanco
authors.forename: J M
authors.initials: JM
authors.lastname: Requena
authors.forename: C
authors.initials: C
authors.lastname: Alonso
authors.forename: I
authors.initials: I
authors.lastname: Navarrete
mesh_terms: D000818:Animals; D000913:Antibodies, Protozoan / Q000097:blood / Q000134:cerebrospinal fluid* / Q000378:metabolism*; D000953:Antigens, Protozoan / Q000378:metabolism; D001082:Aqueous Humor / Q000276:immunology*; D001812:Blood-Brain Barrier; D002490:Central Nervous System / Q000276:immunology / Q000469:parasitology / Q000473:pathology*; D002531:Cerebellum / Q000276:immunology / Q000469:parasitology / Q000473:pathology; D002831:Choroid Plexus / Q000276:immunology / Q000469:parasitology / Q000473:pathology; D004285:Dogs; D007074:Immunoglobulin G / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism; D018314:Leishmania infantum / Q000276:immunology*; D007898:Leishmaniasis, Visceral / Q000276:immunology* / Q000469:parasitology / Q000473:pathology*
chemical_list: D000913:Antibodies, Protozoan; D000953:Antigens, Protozoan; D007074:Immunoglobulin G