Albendazole and praziquantel treatment in neurocysticercosis of the fourth ventricle.
The purpose of this study was to determine the therapeutic efficacy of albendazole and praziquantel administration in the treatment of neurocysticercosis of the fourth ventricle. The authors report the results obtained in 10 patients with cystic neurocysticercosis of the fourth ventricle who were treated with albendazole at a dosage of 15 mg/kg/day for 2 weeks. Because of the failure of albendazole treatment, two of the patients received an additional course of praziquantel at a dosage of 100 mg/kg/day for 2 weeks. A total of 16 courses of albendazole and two courses of praziquantel were administered to the 10 patients. In eight patients (80%), there was complete disappearance of the cyst, in one other (10%) there was an important decrease in the size of the cyst, and in one (10%), no change was seen. None of the patients had complications during the follow-up period of between 6 and 26 months (average 15.7 months). The authors postulate that a regimen of albendazole is the treatment of choice for this type of neurocysticercosis, although praziquantel may also be useful.
Proaño
J V
JV
Neurosurgery Service, Specialties Hospital, Twenty-First Century National Medical Center, Mexican Institute of Social Security, Mexico City.
Madrazo
I
I
García
L
L
García-Torres
E
E
Correa
D
D
D000328:Adult; D015766:Albendazole / Q000627:therapeutic use*; D000871:Anthelmintics / Q000627:therapeutic use*; D000980:Antiplatyhelmintic Agents / Q000627:therapeutic use*; D001927:Brain Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000469:parasitology; D002552:Cerebral Ventricles / Q000469:parasitology* / Q000473:pathology; D003551:Cysticercosis / Q000175:diagnosis / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011223:Praziquantel / Q000627:therapeutic use*; D016896:Treatment Outcome
D000871:Anthelmintics; D000980:Antiplatyhelmintic Agents; D011223:Praziquantel; D015766:Albendazole