Pharmacokinetic considerations in the development of peptide-based imaging agents.
Pharmacokinetic factors to be considered in the development of peptide-based imaging agents are reviewed. These include size, plasma protein binding, lipophilicity, resistance or susceptibility to proteolysis and radiolabel integrity. These factors are discussed in the context of several examples of thrombus and tumor imaging agents either commercially available or in development.
Lister-James
J
J
Diatide Inc., Londonderry, NH 03053, USA.
Moyer
B R
BR
Dean
R T
RT
D000818:Animals; D006801:Humans; D008970:Molecular Weight; D010455:Peptides / Q000737:chemistry / Q000493:pharmacokinetics*; D019275:Radiopharmaceuticals / Q000737:chemistry / Q000493:pharmacokinetics*
D010455:Peptides; D019275:Radiopharmaceuticals