title: Effects of red wine on 24-hour esophageal pH and pressures in healthy volunteers.
abstract: The purpose of this study was to assess the effects of red wine taken with meals on esophageal motility, esophageal exposure to acid, and gastric pH. Following a randomized design, 14 healthy male volunteers (mean age 25 years, range 18-35 years were given 360 ml of red wine or tap water during lunch or dinner. All subjects underwent ambulatory 24-hr esophageal motility and esophagogastric pH monitoring studies. Three different periods were analyzed: during meals (30 min), postprandial (3 hr), and 8-hr supine. Two volunteers complained of heartburn after wine ingestion. An increase in the number of high amplitude waves (> 125 mm Hg, 95th percentile of our motility unit controls) was observed during meals accompanied by wine: water 1.2 (0-10.2), wine 1.6 (0-32.6), P = 0.02 [median (range)]. No other esophageal motility changes occurred. Percent reflux time increased during the postprandial period after wine ingestion in comparison with water: 1.7 (0-14.9) vs 0.1 (0-0.8), P < 0.05. Gastric pH was unaffected by the type of drink. Ingestion of moderate amounts of red wine with meals increases postprandial esophageal exposure to gastric acid in healthy persons.
authors.affiliation: Department of Surgery, Hospital Clinic i Provincial, University of Barcelona, Spain.
authors.forename: L
authors.initials: L
authors.lastname: Grande
authors.forename: C
authors.initials: C
authors.lastname: Manterola
authors.forename: E
authors.initials: E
authors.lastname: Ros
authors.forename: G
authors.initials: G
authors.lastname: Lacima
authors.forename: C
authors.initials: C
authors.lastname: Pera
mesh_terms: D000328:Adult; D000428:Alcohol Drinking; D004947:Esophagus / Q000502:physiology*; D005502:Food; D005745:Gastric Acidity Determination; D006356:Heartburn / Q000209:etiology; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008991:Monitoring, Physiologic; D010528:Peristalsis / Q000502:physiology; D011187:Posture; D011312:Pressure; D011446:Prospective Studies; D014920:Wine / Q000009:adverse effects