Differential expression of FGF-2 isoforms in the rat adrenal medulla during postnatal development in vivo.
Basic fibroblast growth factor (FGF-2) isoforms of the adrenal medulla are differentially expressed during rat postnatal development. While the 18 and 23 kDa isoforms continuously rise towards the adult expression level, the 21 kDa isoform displays a peak expression at postnatal day 28. The peak expression of the 21 kDa isoform correlates with the peak of the corticosterone concentration during postnatal development. Together with the previously demonstrated increase of the 21 kDa isoform in the adrenal medulla in vivo after glucocorticoid administration these results suggest that the differential regulation of the FGF-2 isoforms could be a physiologically occurring mechanism.
Meisinger
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Institute of Anatomy II, University of Freiburg, Germany.
Grothe
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D000313:Adrenal Medulla / Q000378:metabolism*; D000818:Animals; D000831:Animals, Newborn / Q000254:growth & development* / Q000378:metabolism; D015153:Blotting, Western; D003345:Corticosterone / Q000378:metabolism; D003513:Cycloheximide / Q000494:pharmacology; D003720:Densitometry; D003907:Dexamethasone / Q000494:pharmacology; D016222:Fibroblast Growth Factor 2 / Q000235:genetics / Q000378:metabolism*; D005938:Glucocorticoids / Q000494:pharmacology; D007536:Isomerism; D008297:Male; D009994:Osmolar Concentration; D016716:PC12 Cells; D011500:Protein Synthesis Inhibitors / Q000494:pharmacology; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
D005938:Glucocorticoids; D011500:Protein Synthesis Inhibitors; D012333:RNA, Messenger; D016222:Fibroblast Growth Factor 2; D003907:Dexamethasone; D003513:Cycloheximide; D003345:Corticosterone