Influence of captopril on some haemostatic parameters in rats with ongoing process of venous thrombosis.
Recent laboratory findings strongly suggest that renin-angiotensin system plays an important role in regulation of haemostasis and fibrinolysis. In our previous study we showed that captopril exerts antithrombotic effect in venous thrombosis in rats. In this study we demonstrated that this effect is not a result of changes in platelet count, fibrinogen level alterations in blood coagulation pathways and fibrinolytic activity of the plasma. Further investigations are necessary to elucidate the mechanism of antithrombotic action of captopril.
Pawlak
R
R
Department of Pharmacodynamics, Medical School, Białystok, Poland.
Chabielska
E
E
Rółkowski
R
R
Buczko
W
W
D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects; D002216:Captopril / Q000494:pharmacology*; D006487:Hemostasis / Q000187:drug effects*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013924:Thrombophlebitis / Q000097:blood*
D002216:Captopril