Band 1p36 abnormalities and t(1;17) in ovarian carcinoma.
In a series of 128 karyotyped ovarian carcinomas, 42% of cases with chromosome 1 clonal structural abnormalities had breaks at band 1p36 (usually involving translocations of unknown material). Fluorescent in situ hybridization (FISH) studies using combinations of 1 centromere and 1p36.3-specific probes (16 cases) or 1 centromeric and 17 whole-chromosome paint probes (11 cases with 1p+) revealed a trend toward deletion of 1pter relative to 1 centromere (63%); intratumor heterogeneity; and the origin of 1p+ in 3/11 cases (27%) from chromosome 17 [t(1;17)(p36;?)]. The frequency of this specific breakpoint and its involvement in recurrent translocations suggest that these regions are loci for genes important in the pathogenesis of a subset of sporadic ovarian carcinomas.
Thompson
F H
FH
Arizona Cancer Center, College of Medicine, University of Arizona, Tucson, USA.
Taetle
R
R
Trent
J M
JM
Liu
Y
Y
Massey-Brown
K
K
Scott
K M
KM
Weinstein
R S
RS
Emerson
J C
JC
Alberts
D S
DS
Nelson
M A
MA
D000230:Adenocarcinoma / Q000235:genetics*; D002869:Chromosome Aberrations / Q000235:genetics; D025063:Chromosome Disorders; D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1; D002886:Chromosomes, Human, Pair 17; D004276:DNA, Satellite; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D010051:Ovarian Neoplasms / Q000235:genetics*; D014178:Translocation, Genetic
D004276:DNA, Satellite