title: Seizures in special populations. Children, the elderly, and patients with coexistent medical illness.
abstract: Epilepsy management may need to be modified in certain patient groups. The management of epilepsy in all age-groups, and particularly in children, may be best approached from a disease-based model that recognizes specific epilepsy syndromes. Accurate diagnosis of pediatric epilepsy syndromes allows the physician to improve medication selection, estimate duration of treatment, and counsel patients and family members about aggravating factors and prognosis. Epilepsy management in elderly patients requires knowledge of age-related changes in the metabolism and protein binding of anticonvulsants and how these changes affect use of particular antiepileptic drugs. Concurrent medical illness, especially renal and hepatic disease, may alter drug distribution, metabolism, and excretion in some patients. In addition, a number of medications used to treat coexistent medical or psychiatric illness are associated with seizure provocation. Knowledge of these factors can improve epilepsy management in special patient populations.
authors.affiliation: Comprehensive Epilepsy Center, Temple University School of Medicine, Philadelphia, PA 19140, USA. hulihan@astro.ocis.temple.edu
authors.forename: J F
authors.initials: JF
authors.lastname: Hulihan
mesh_terms: D000368:Aged; D000927:Anticonvulsants / Q000493:pharmacokinetics / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D004347:Drug Interactions; D004827:Epilepsy / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism; D006801:Humans; D007223:Infant; D007674:Kidney Diseases / Q000150:complications; D008107:Liver Diseases / Q000150:complications
chemical_list: D000927:Anticonvulsants