title: Linear IgA disease and ulcerative colitis.
abstract: Seventy adult patients with linear IgA disease were studied. Five (7.1%) also suffered from ulcerative colitis (the prevalence of ulcerative colitis in the U.K. is 0.05%). A further three patients with this association, from other British centres were also reviewed. In all cases, ulcerative colitis preceded the onset of skin disease, by a median of 6.5 years. The reason for this association remains unclear but the abnormalities in colonic mucosal B cells and mucosal IgA1 production reported in patients with ulcerative colitis may be important in the subsequent development of IgA1 mediated linear IgA disease.
authors.affiliation: Department of Dermatology, St Mary's Hospital, London, UK.
authors.forename: D G
authors.initials: DG
authors.lastname: Paige
authors.forename: J N
authors.initials: JN
authors.lastname: Leonard
authors.forename: F
authors.initials: F
authors.lastname: Wojnarowska
authors.forename: L
authors.initials: L
authors.lastname: Fry
mesh_terms: D000328:Adult; D000368:Aged; D001327:Autoimmune Diseases / Q000150:complications* / Q000276:immunology; D002648:Child; D003093:Colitis, Ulcerative / Q000150:complications* / Q000276:immunology; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D012872:Skin Diseases, Vesiculobullous / Q000150:complications* / Q000276:immunology
chemical_list: D007070:Immunoglobulin A