[Total intravenous anesthesia with propofol in orthotopic liver transplantation in swine].
OBJECTIVE
To study the use of total intravenous anesthesia with propofol as an anesthetic model for orthotopic liver transplantation (OLT) in pigs. ANIMALS AND METHOD: Fifteen OLT were performed in pigs using portacava-jugular veno-venous shunt with an injector pump. Anesthesia was maintained by perfusion of 10 mg/kg/h propofol. Hemodynamic and biochemical measurements were recorded at the following times: AO, baseline; AI, five minutes before removal of the liver; B1, five minutes later but before starting the bypass injector pump; B2, five minutes after starting the injector pump; B3, five minutes before reperfusion; C1, five minutes after starting reperfusion, and C2, after aortic declamping.


RESULTS
No cases of malignant hyperthermia appeared. When the liver was removed cardiac output decreased (p < 0.01), as did mean arterial pressure (p < 0.01), mixed venous saturation (p < 0.05), pulmonary capillary pressure and temperature (p < 0.05). Pulmonary vascular resistances increased (p < 0.05).


CONCLUSIONS
The use of total intravenous anesthesia with propofol is a satisfactory experimental anesthetic model for OLT in pigs, and it prevents the possible appearance of malignant hyperthermia.
Ramírez
A
A
Unidad Experimental, Ciudad Sanitaria Virgen de las Nieves, Granada.
Martínez
M
M
Jiménez
J
J
Garrote
D
D
Cabrera
M A
MA
Villar
J
J
Ferrón
J A
JA
D000768:Anesthesia, General; D000771:Anesthesia, Intravenous; D018686:Anesthetics, Intravenous; D000818:Animals; D005260:Female; D016031:Liver Transplantation; D015742:Propofol; D013552:Swine
D018686:Anesthetics, Intravenous; D015742:Propofol