[Determination of platelet activating factor and platelet associated IgG in pregnancy-induced hypertension].
OBJECTIVE
To determine the levels of platelet activating factor (PAF) and platelet associated IgG (PAIgG) in pregnancy-induced hypertension (PIH).


METHODS
Twenty-eight cases of normal pregnant women and 44 cases of PIH (moderate, n = 23; severe, n = 21) were enrolled in this study. The plasma level of PAF was measured using platelet aggregation bioassay, and determination of PAIgG was performed by ABC-ELISA (enzyme-labeled immunosorbent assay) method.


RESULTS
The level of plasma PAF in PIH patients (5.02 +/- 1.93 micrograms/L) was significantly higher than that in the controls (1.16 +/- 0.22 micrograms/L, P < 0.01). There was no difference between the levels of PAF in moderate PIH and severe ones. The level of PAIgG in PIH (6.3 +/- 4.9 micrograms/10(2)) was significantly higher than that in the control (3.8 + 1.8 micrograms/10(2), P < 0.05).


CONCLUSIONS
PAF may be involved and play an important role in the pathophysiological changes in PIH. Autoimmunological reaction of platelets may exist in pregnant women with PIH.
Zhang
S
S
Affiliated Hospital, Shangdong Medical University, Jinan.
Zhang
Y
Y
Liu
B
B
D000328:Adult; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D010972:Platelet Activating Factor / Q000032:analysis*; D011225:Pre-Eclampsia / Q000097:blood* / Q000276:immunology; D011247:Pregnancy
D007074:Immunoglobulin G; D010972:Platelet Activating Factor