title: A robust assessment of the NoGo-anteriorisation of P300 microstates in a cued Continuous Performance Test.
abstract: The Continuous Performance Test (CPT) is successfully applied in clinical routine to evaluate attentional performance. The aim of the present study was to investigate the features of the ERPs related to the conditions of a cued CPT, in particular the Go- and the NoGo-condition demanding either the execution or the inhibition of a prepared motor response. For that purpose, 21-channel-ERPs of ten healthy subjects elicited by the Go, NoGo, primer and distractor cues were analyzed with reference-independent methods. The P300 microstates were identified by means of a data-driven segmentation of the ERPs based on the individual peaks of the Global Field Power (GFP). The topographical assessment of the P300 fields yielded an extraordinarily robust result consisting of a more anterior location of the positive centroid in the NoGo compared to the Go condition in every single subject. In conclusion, this result is an impressive validation of the applied reference-independent spatial analysis which reveals the rapid changes of the brain electrical field configurations related to the execution/inhibition paradigm within the cued CPT. Because of the stability of the NoGo anteriorisation we propose to use this parameter as a topographical standard index, analogous to the amplitude effect between oddball targets and nontargets which defines the classical P300.
authors.affiliation: Dept. of Psychiatry, University Hospital of Würzburg, Germany.
authors.forename: A J
authors.initials: AJ
authors.lastname: Fallgatter
authors.forename: D
authors.initials: D
authors.lastname: Brandeis
authors.forename: W K
authors.initials: WK
authors.lastname: Strik
mesh_terms: D000328:Adult; D001931:Brain Mapping; D003463:Cues; D004569:Electroencephalography; D018913:Event-Related Potentials, P300 / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D011597:Psychomotor Performance / Q000502:physiology*