[Enhancement of treatment efficacy in experimental plague by the sequential administration of antibiotics].
It was shown that the use of ampicillin, azlocillin or polymyxin 24 or 96 hours after the plague infection at the background of the every-day use of rifampicin in the doses protecting only 30 per cent of the animals from death provided 80-100-percent survival of the animals. With the every-day use of ampicillin, azlocillin or polymyxin in succession with rifampicin there was observed a 3-fold increases in the survival of the albino mice as compared to those exposed to an analogous dose of rifampicin alone. A decrease in the number of administrations of the above drugs and an increase in the intervals between the administration also resulted in a significant rise of the animal survival in comparison with that after the every-day use of a similar dose of rifampicin.
Makarovskaia
L N
LN
Tinker
L A
LA
Markovskaia
E I
EI
Zurabian
V A
VA
Ryzhkova
V V
VV
D000667:Ampicillin / Q000008:administration & dosage*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D001390:Azlocillin / Q000008:administration & dosage*; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination / Q000008:administration & dosage*; D051379:Mice; D010406:Penicillins / Q000008:administration & dosage*; D010930:Plague / Q000188:drug therapy* / Q000401:mortality; D011112:Polymyxin B / Q000008:administration & dosage*; D013997:Time Factors
D000900:Anti-Bacterial Agents; D010406:Penicillins; D000667:Ampicillin; D001390:Azlocillin; D011112:Polymyxin B