[The present status and future perspectives of fluorinated quinolones from the aspect of clinical microbiology].
The author presents a review on the contemporary position of fluoroquinolones from the microbiological and clinical aspect. He submits basic data on the mechanism of action of these drugs and development of resistance displayed by infectious agents. Favourable pharmacokinetics make wide clinical use of these drugs possible. Indiscriminate administration could debase these drugs possible. Indiscriminate administration could debase these very valuable antimicrobial drugs. This is why the author presents in his paper the main clinical indications for their therapeutic use. To complete the problem the author makes suggestions of suitable combinations and draws attention to possible therapeutic interactions and undesirable effects, incl. contraindications.
Lochmann
O
O
Ustav lékarské mikrobiologie 2. I.F UK, Praha.
D000890:Anti-Infective Agents / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D004352:Drug Resistance, Microbial; D024841:Fluoroquinolones; D006801:Humans
D000890:Anti-Infective Agents; D024841:Fluoroquinolones