title: Endovascular embolization of intracranial aneurysms with self-made tungsten coils in a dog model.
abstract: OBJECTIVE
  To evaluate the embolization effects and the long-term histologic changes, including the ultrastructure of the neoendothelium, in experimental canine aneurysms obliterated with self-made tungsten microcoil.
  
  
  METHODS
  Twenty-eight experimental aneurysms were microsurgically created in 14 mongrel dogs by using end-to-side jungular carotid anastomosis. The aneurysms were obliterated with either self-made tungsten microcoil alone or the microcoil plus micro direct current electrocoagulation, with preservation of the parent vessel. The animals were kept in observation. 48 hours, 4 weeks, and 4 months after the embolization of the aneurysms, repeated carotid arteriography was performed to assess the potential recanalization of the aneurysms. The animals were then respectively killed and submitted for autopsy. The carotid artery and the embolized aneurysms were resected and studied with light and electron microscopy.
  
  
  RESULTS
  A total of 14 obliterated aneurysms were completely excluded from the parent circulation by an endothelialized layer of connective tissue. The fundus of the aneurysm was completely obliterated by heavy reactive fibrous tissue surrounding the microcoils with very minimal inflammatory reaction.
  
  
  CONCLUSIONS
  Tungsten microcoils are a relatively ideal embolic material at present for endovascular treatment of aneurysms. Microcoils plus micro direct current electrocoagulation yield more reliable, accurate, and safer embolic effects than microcoils alone for the obliteration of aneurysms.
authors.affiliation: Neurosurgery Institute, Harbin Medical University.
authors.forename: Z
authors.initials: Z
authors.lastname: Huang
authors.forename: Q
authors.initials: Q
authors.lastname: Dai
authors.forename: T
authors.initials: T
authors.lastname: Jiang
authors.forename: J
authors.initials: J
authors.lastname: Li
mesh_terms: D000818:Animals; D002339:Carotid Arteries; D002404:Catheterization; D004285:Dogs; D004621:Embolization, Therapeutic / Q000379:methods*; D002532:Intracranial Aneurysm / Q000473:pathology / Q000628:therapy*; D014414:Tungsten
chemical_list: D014414:Tungsten