title: Mouse mammary tumor virus: a virus that exploits the immune system.
abstract: Mouse mammary tumor virus (MMTV) causes mammary carcinomas and T-cell tumors in mice. MMTV variants that induce T-cell tumors have a large deletion within the U3 region of the long terminal repeat (LTR) compared to MMTV strains that induce mammary tumors. We provide evidence here that T-cell tropic MMTV strains lack a redundant binding site for a cellular protein called NBP (negative regulatory element binding protein). The lack of NBP-binding sites in T-cell tropic MMTV strains presumably leads to higher levels of transcription in T-cells during the MMTV life cycle and an increased incidence of mutagenic integration events.
authors.affiliation: Dept. of Microbiology, University of Pennsylvania Medical School, Philadelphia 19104, USA.
authors.forename: D
authors.initials: D
authors.lastname: Bramblett
authors.forename: J
authors.initials: J
authors.lastname: Liu
authors.forename: M
authors.initials: M
authors.lastname: Lozano
authors.forename: L
authors.initials: L
authors.lastname: Xu
authors.forename: T
authors.initials: T
authors.lastname: Wrona
authors.forename: L
authors.initials: L
authors.lastname: Rajan
authors.forename: S R
authors.initials: SR
authors.lastname: Ross
authors.forename: J
authors.initials: J
authors.lastname: Dudley
mesh_terms: D000818:Animals; D001483:Base Sequence; D001665:Binding Sites; D004268:DNA-Binding Proteins / Q000378:metabolism; D005260:Female; D016399:Lymphoma, T-Cell / Q000276:immunology* / Q000821:virology*; D008325:Mammary Neoplasms, Experimental / Q000276:immunology / Q000821:virology; D008324:Mammary Tumor Virus, Mouse / Q000235:genetics / Q000276:immunology*; D051379:Mice; D008809:Mice, Inbred C3H; D009687:Nuclear Proteins / Q000378:metabolism; D011994:Recombinant Proteins / Q000096:biosynthesis; D012091:Repetitive Sequences, Nucleic Acid; D012192:Retroviridae Infections / Q000276:immunology*; D017384:Sequence Deletion; D014157:Transcription Factors / Q000378:metabolism*; D014158:Transcription, Genetic; D014162:Transfection; D014412:Tumor Virus Infections / Q000276:immunology*
chemical_list: D004268:DNA-Binding Proteins; D009687:Nuclear Proteins; D011994:Recombinant Proteins; C083666:Son protein, mouse; D014157:Transcription Factors