title: Sodium balance of hyper- and hypo-natriophilic rats under basal conditions and during sodium deprivation.
abstract: Sodium and water balance was determined in two strains of Wistar rats selectively bred for high (hypernatriophilic, HR) or low salt preference (hyponatriophilic, HO) under basal conditions and during sodium deprivation. Male rats from each stain were selected for an average ingestion of 1.5% NaCl solution of more than (HR) or less than (HO) 4 ml 100 g body weight (-1) day (-1), during a 10-day period. HR rats (N = 17) presented markedly higher sodium intake under basal conditions (2.983 +/- 0.316 mEq 100 g body weight (-1) day (-1)) than HO rats (N = 12; 0.406 +/- 0.076 mEq 100 g body weight (-1) day (-1); Mann-Whitney test, P < 0.01). Water (HR: 8.6 +/- 0.57; HO: 7.7 +/- 0.32 ml 100 g body weight (-1) day (-1)) and sodium balances (HR: 0.936 +/- 0.153; HO: 0.873 +/- 0.078 mEq 100 g body weight (-1) day (-1)) were similar in both strains, despite a higher sodium and total fluid (HR: 16.3 +/- 1.06; HO: 10.8 +/- 0.49 ml 100 g body weight (-1) day (-1); P < 0.01) ingestion in HR rats. During sodium deprivation HR rats (N = 13) exhibited a sodium balance similar to that of HO rats (N = 13) (HR: -0.159 +/- 0.011; HO: -0.129 +/- 0.019 mEq 100 g body weight (-1) day (-1)), and, in addition, an adequate suppression of natriuresis (HR: 0.049 +/- 0.011; HO: 0.026 +/- 0.004 mEq 100 g body weight (-1) day (-1)). These data show that HR rats present hypernatriophilia as a primary trait, since their sodium-conserving mechanisms are intact. Therefore, these rats provide an adequate model to study factors that determine innate sodium preference.
authors.affiliation: Departamento de Fisiologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Brasil. helglass@usp.br
authors.forename: H
authors.initials: H
authors.lastname: Glass
authors.forename: J
authors.initials: J
authors.lastname: Gutkowska
authors.forename: A L
authors.initials: AL
authors.lastname: Favaretto
authors.forename: A
authors.initials: A
authors.lastname: Carneiro-Leão
authors.forename: J
authors.initials: J
authors.lastname: Antunes-Rodrigues
mesh_terms: D000818:Animals; D005260:Female; D006955:Hypernatremia / Q000503:physiopathology*; D007010:Hyponatremia / Q000503:physiopathology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D017673:Sodium Chloride, Dietary
chemical_list: D017673:Sodium Chloride, Dietary