[Ornithine induced retinopathy in rat--2. Process of disappearance of choriocapillaris].
We observed the process of disappearance of the choriocapillaris after loss of the retinal pigment epithelium (RPE) induced by intravitreal injection or ornithine. Three hours after administration of ornithine, the RPE cells swelled remarkably in the posterior pole, but, the endothelial cells of the choriocapillaris remained intact. At 3 days, the RPE cells became necrotic, but the choriocapillaris still preserved its in normal appearance. At 7 days, RPE disappeared completely in the posterior pole and the choriocapillaris displayed evidence of atrophy; the swollen lumen of the choriocapillaris became narrow the cytoplasm of the endothelium was swollen, and the number of fenestrae was reduced. On the other hand, these changes were not seen where the RPE remained. At 14 days, in the posterior pole, the lumen of the choriocapillaris occluded by the swollen endothelial cells. At 28 days, the choriocapillaris completely disappeared and the large choroidal vessel was directly in contact with Bruch's membrane. These results showed that the RPE is correlated with the presence of the choriocapillaris.
Maeda
H
H
Department of Ophthalmology, Kansai Medical University, Osaka-fu, Japan.
Takeuchi
M
M
Takahashi
K
K
Itagaki
T
T
Ohkuma
H
H
Uyama
M
M
D000818:Animals; D001284:Atrophy; D002196:Capillaries / Q000187:drug effects / Q000648:ultrastructure; D002829:Choroid / Q000098:blood supply*; D008854:Microscopy, Electron; D009336:Necrosis; D009952:Ornithine / Q000633:toxicity*; D010857:Pigment Epithelium of Eye / Q000187:drug effects* / Q000648:ultrastructure; D051381:Rats; D012164:Retinal Diseases / Q000139:chemically induced / Q000473:pathology*; D013997:Time Factors
D009952:Ornithine