Effect of almokalant a specific inhibitor of IKr on myocardial ischaemia-reperfusion induced arrhythmias in rabbits.
The antiarrhythmic effect of almokalant, a new type III antiarrhythmic agent, was examined by occluding and releasing the left circumflex coronary artery for 10 min, respectively, in openchest, pentobarbital-anaesthetized albino rabbits. Almokalant pretreatment increased the number of animals developing no arrythmias (5/9 vs. 1/12 in controls), and decreased the incidence of ventricular fibrillation (1/9 vs. 9/12) during reperfusion. According to our results almokalant can protect the heart against arrhythmias induced by ischaemia and reperfusion.
Farkas
A
A
Department of Pharmacology, Albert Szent-Györgyi Medical University, Szeged, Hungary.
Leprán
I
I
Papp
J G
JG
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology*; D001145:Arrhythmias, Cardiac / Q000209:etiology* / Q000517:prevention & control; D004553:Electric Conductivity; D005260:Female; D008297:Male; D017202:Myocardial Ischemia / Q000150:complications*; D015428:Myocardial Reperfusion Injury / Q000150:complications*; D011188:Potassium / Q000037:antagonists & inhibitors / Q000502:physiology*; D011412:Propanolamines / Q000494:pharmacology*; D011817:Rabbits
D000889:Anti-Arrhythmia Agents; D011412:Propanolamines; C074334:almokalant; D011188:Potassium