Pulmonary infiltrates with masto- and lymphocytosis in BALF associated with arechine.
Pulmonary infiltrates developed in a 40-year-old man while receiving arechine. The hyperplasia of mast cells, hyperlymphocytosis, a predominance of cytotoxic T-cells of the CD8 type with the very low CD4/CD8 ratio in BAL were observed. The chest roentgenogram findings resolved within a month after discontinuing arechine therapy. A hypersensitivity reaction with the onset of lung fibrosis due to arechine seemed to be the likely cause.
Jedynak
U
U
Department of Clinical Pathophysiology, Jagiellonian University Medical College, Kraków.
Ciezarek
M
M
Kopiński
P
P
D000328:Adult; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology*; D002465:Cell Movement / Q000187:drug effects*; D002738:Chloroquine / Q000009:adverse effects*; D005355:Fibrosis; D006801:Humans; D008168:Lung / Q000187:drug effects / Q000473:pathology*; D008218:Lymphocytosis / Q000139:chemically induced / Q000473:pathology*; D008297:Male; D008415:Mastocytosis / Q000139:chemically induced / Q000473:pathology*
D002738:Chloroquine