title: Nonpeptide angiotensin II receptor antagonists: synthesis and biological activity of 1H-imidazo and 1H-[1,2,3]-triazolo fused derivatives.
abstract: A series of 1H-Imidazo and 1H-[1,2,3]-Triazolo fused derivatives have been obtained and tested as non peptide AII receptor antagonists. Modification of the classical biphenyl moiety to a 4-arylthienyl fragment afforded interesting activities.
authors.affiliation: Departamento de Química Orgánica, Universidad de Alcalá, Madrid, Spain.
authors.forename: F
authors.initials: F
authors.lastname: Delgado
authors.forename: J
authors.initials: J
authors.lastname: Pastor
authors.forename: J L
authors.initials: JL
authors.lastname: García-Navío
authors.forename: J J
authors.initials: JJ
authors.lastname: Vaquero
authors.forename: J
authors.initials: J
authors.lastname: Alvarez-Builla
authors.forename: C
authors.initials: C
authors.lastname: Sunkel
authors.forename: M F
authors.initials: MF
authors.lastname: de Casa-Juana
authors.forename: J G
authors.initials: JG
authors.lastname: Priego
authors.forename: L R
authors.initials: LR
authors.lastname: Santos
authors.forename: P R
authors.initials: PR
authors.lastname: Statkow
authors.forename: D
authors.initials: D
authors.lastname: Straumann
mesh_terms: D057911:Angiotensin Receptor Antagonists; D000818:Animals; D006168:Guinea Pigs; D007093:Imidazoles / Q000737:chemistry / Q000494:pharmacology*; D066298:In Vitro Techniques; D015394:Molecular Structure; D011817:Rabbits; D011945:Receptors, Angiotensin / Q000737:chemistry; D013329:Structure-Activity Relationship; D014230:Triazoles / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D057911:Angiotensin Receptor Antagonists; D007093:Imidazoles; D011945:Receptors, Angiotensin; D014230:Triazoles