A new retroviral AIDS-like disease and/or acute leukemia induced in mice by alloimmune stimuli.
We have shown a new phenomenon demonstrating that BALB/c female mice mated to C57BL/6 males during a year (7-10 pregnancies) develop AIDS-like disease or acute leukemia after an additional immunization with fixed ConA activated paternal (C57BL/6) lymphocytes. The AIDS-like disease is sexually and vertically transmissible and easily transferable to intact BALB/c and C57BL/6 mice by filtered plasma of affected animals.
Ter-Grigorov
V
V
Kimron Veterinary Institute, Bet Dagan, Israel.
Krifuks
O
O
Liubashevsky
E
E
Nyska
A
A
Toder
V
V
Trainin
Z
Z
D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology / Q000635:transmission; D000818:Animals; D001323:Autoantibodies / Q000096:biosynthesis; D016913:Blood Component Transfusion; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D003208:Concanavalin A; D003307:Copulation; D003433:Crosses, Genetic; D005260:Female; D000949:Histocompatibility Antigens Class II / Q000276:immunology; D007114:Immunization; D018445:Infectious Disease Transmission, Vertical; D007376:Interleukin-2 / Q000096:biosynthesis; D007942:Leukemia, Experimental / Q000276:immunology* / Q000821:virology*; D008213:Lymphocyte Activation; D017710:Lymphocyte Transfusion; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000821:virology; D012190:Retroviridae; D014184:Transplantation, Homologous
D001323:Autoantibodies; D000949:Histocompatibility Antigens Class II; D007376:Interleukin-2; D003208:Concanavalin A