[Manufacture of computer-based testing and analyzing system for measuring step-through performance].
The computer-Based Testing and Analysing System for measuring Step-Through (avoiding darkness) performance (CTASS) has been developed. The system is based on the infrared beams which transfer actions of mice inside the boxes into signals of voltage. The signals are fed into the computer through A/D converter to computer for software processing. The functions which have been realized include, but not limited to: signal sampling and data curve displaying; intelligent identification and elimination of jamming signal; auto-calculation of number of errors (No) in all channels, latent period (LP) of entering into the light chamber, total time of mice staying in the light chamber (safty place Tl) and dark chamber (error place Td); hardcopy of screen graphics and resulting output by various printers. The CATSS system was applied to test normal mice and the cognition-deficient mice induced by anisodine, a M-Cholinergic antagonist at a dose of 1-10 mg/kg i.p. The data collected by the system were compared and proved to be consistent with those acquired by manual labour. The system has produced refined and accurate information refined to a maximum extent and guaranteed scientifically sound experimental results. It is foreseable that introducing the computer into pharmacological researches will update and advance their methodology.
Liu
X
X
Institute of Medicial Plant Development, CAMS, Beijing.
Cheng
S
S
Wang
S
S
Xing
Z
Z
Wang
L
L
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D003072:Cognition Disorders / Q000139:chemically induced / Q000503:physiopathology*; D051379:Mice; D018727:Muscarinic Antagonists; D012602:Scopolamine Derivatives; D012815:Signal Processing, Computer-Assisted
D018727:Muscarinic Antagonists; D012602:Scopolamine Derivatives; C012183:anisodine