title: Anti-HIV active naphthyl analogues of HEPT and DABO.
abstract: 5-Ethyl-6-(1-naphthylmethyl)uracil and 5-ethyl-6-(1-naphthylmethyl)-2-thiouracil were alkylated to give, respectively. N-1 and S2, ethoxymethyl and methylthiomethyl uracil derivatives. 5-Ethyl-6-(1-naphthylmethyl)-2-thiouracil was also S2 alkylated with methyl bromoacetate. The products showed activity against HIV-1, and the N-1 alkylated derivatives were indeed highly active.
authors.affiliation: Department of Chemistry, Odense University, Denmark.
authors.forename: K
authors.initials: K
authors.lastname: Danel
authors.forename: C
authors.initials: C
authors.lastname: Nielsen
authors.forename: E B
authors.initials: EB
authors.lastname: Pedersen
mesh_terms: D019380:Anti-HIV Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D002460:Cell Line; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D013889:Thiouracil / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D014498:Uracil / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology
chemical_list: C107134:5-ethyl-6-(1-naphthylmethyl)-2-thiouracil; C107133:5-ethyl-6-(1-naphthylmethyl)uracil; D019380:Anti-HIV Agents; D014498:Uracil; D013889:Thiouracil