Sudden cerebral vasoconstriction during induced polymorphic ventricular tachycardia and fibrillation: further observations of a paradoxic response.
To determine the effect of induced polymorphic VT/VF on the cerebral circulation, transcranial Doppler (TCD) ultrasonography was used to prospectively assess changes in cerebral blood flow velocity during ICD implantation. Fourteen patients (13 men, 1 woman, mean age 58 +/- 20 years, range 34-74 years) who were survivors of an out of hospital cardiac arrest, were evaluated during routine ICD implantation. TCD ultrasonography was used to assess middle cerebral artery systolic velocity (Vs), diastolic velocity (Vd), pulsatility index (PI = Vs-Vd/Vmean) and resistance index (RI = Vs-Vd/Vs) before, during, and after DFT testing with alternating current induction of polymorphic VT/VF. In each of the 14 patients studied, concomitant with the abrupt onset of hypotension, TCD sonography demonstrated a 33% +/- 28% decrease in diastolic velocity, a 42% +/- 28% increase in systolic velocity, a 190% +/- 141% increase in PI, and a 44% +/- 19% increase in RI. These findings reflect an increase in cerebrovascular resistance secondary to arteriolar vasoconstriction distal to the point of insonation of the middle cerebral artery. This response is paradoxic, as the expected response of the cerebral circulation to hypotension is vasodilation, but it is consistent with observations made in other acute hypotensive settings, such as tilt induced neurocardiogenic syncope.
Grubb
B P
BP
Department of Medicine, Medical College of Ohio, Toledo 43699, USA.
Durzinsky
D
D
Brewster
P
P
Gbur
C
C
Collins
B
B
D001783:Blood Flow Velocity / Q000502:physiology; D002536:Cerebral Arteries / Q000000981:diagnostic imaging / Q000503:physiopathology*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D017147:Defibrillators, Implantable; D005260:Female; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D007022:Hypotension / Q000209:etiology / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D017180:Tachycardia, Ventricular / Q000209:etiology / Q000503:physiopathology*; D017585:Ultrasonography, Doppler, Transcranial; D014661:Vasoconstriction / Q000502:physiology*; D014693:Ventricular Fibrillation / Q000209:etiology / Q000503:physiopathology*