[Study of bone density in systemic scleroderma].
BACKGROUND
Osteopenia in systemic sclerosis (scleroderma) patients was reported in X-ray studies of hands and by proximal and distal forearm bone mass measurement. It has been suggested that bone loss in these patients might be due to chronic ischemia, immobilization and early menopause. Nevertheless, it is not established if these patients present generalized osteopenia. To shed light into this point we studied bone mineral density in the spine, proximal femur and total body in patients with systemic sclerosis.


METHODS
Twenty-five Caucasian women were evaluated. Mean age of patients was 48 +/- 12 years and mean time of disease was 7 +/- 7 years; 13 were postmenopausal (8 +/- 8 years). Bone mass was measured in the spine, proximal femur and total body by using a dual-photon absorptiometry with X rays source (Lunar-Model DPX).


RESULTS
Bone mass in different sites was not statistically different from the age-matched control healthy women. Mean bone mass of patients with limited form was not different from patients with diffuse form of systemic sclerosis. Patients with calcinosis had lower bone mass at proximal femur than those without this alteration.


CONCLUSIONS
Patients with systemic sclerosis do not present bone loss and this disease in not a risk factor for generalized osteoporosis.
da Silva
H C
HC
Universidade Federal de São Paulo, Escola Paulista de Medicina, São Paulo.
Szejnfeld
V L
VL
Assis
L S
LS
Sato
E I
EI
D000328:Adult; D000368:Aged; D015992:Body Mass Index; D015519:Bone Density; D001851:Bone Diseases, Metabolic / Q000209:etiology*; D003720:Densitometry; D005260:Female; D006801:Humans; D008875:Middle Aged; D012595:Scleroderma, Systemic / Q000150:complications*