title: Cerebral microembolism and early recurrent cerebral or retinal ischemic events.
abstract: OBJECTIVE
  We investigated whether cerebral microembolism as detected by transcranial Doppler ultrasonography (TCD) identifies patients at an increased risk for early, recurrent cerebral or retinal ischemic events.
  
  
  METHODS
  Records of consecutive patients examined during a 40-month period in the Neurovascular Laboratory were reviewed for the presence of cerebral microembolism. Of the original 302 patients, 229 with 310 arteries met inclusionary criteria. Follow-up information was obtained from the laboratory's database as well as the hospital records. Microembolus detection studies were performed on TC-2000 or TC-2020 instruments equipped with special software, and criteria established a priori were used for microembolus selection. TCD testing was performed a median interval of 9 days after the initial symptoms of cerebral ischemia. Severity of arterial stenosis was determined by cerebral angiography or noninvasive methods.
  
  
  RESULTS
  Microembolic signals were detected more frequently in symptomatic (40/140; 28.6%) than asymptomatic (21/170; 12.4%) arteries (P < .001). Ten recurrent ischemic events occurred during a median follow-up of 8 days after TCD examination, all in the territories of symptomatic arteries. Nine events occurred in the territories of microembolic signal positive arteries (9/61; 14.8%) and one in the territory of a microembolic signal-negative artery (1/249; 0.4%) (P < .00). No association was detected in the subgroup with known cardiac lesions. Microembolic signals were more frequent in arteries with lesions causing 70% or more stenosis or occlusion (26/99; 26.3%) than in those with a degree of stenosis less than 70% (17/126; 13.5%) (P = .016).
  
  
  CONCLUSIONS
  In this retrospective study, microembolic signals were more common in the territories of symptomatic arteries and particularly those with severely stenotic lesions. During a short follow-up, recurrent ischemic events were more common along the territories of arteries with TCD-detected microembolism and previous symptoms of cerebral or retinal ischemia.
authors.affiliation: Department of Neurology, Boston University School of Medicine, MA 02130, USA.
authors.forename: V L
authors.initials: VL
authors.lastname: Babikian
authors.forename: C A
authors.initials: CA
authors.lastname: Wijman
authors.forename: C
authors.initials: C
authors.lastname: Hyde
authors.forename: N L
authors.initials: NL
authors.lastname: Cantelmo
authors.forename: M R
authors.initials: MR
authors.lastname: Winter
authors.forename: E
authors.initials: E
authors.lastname: Baker
authors.forename: V
authors.initials: V
authors.lastname: Pochay
mesh_terms: D001921:Brain / Q000098:blood supply*; D002545:Brain Ischemia / Q000000981:diagnostic imaging* / Q000209:etiology; D002536:Cerebral Arteries; D002544:Cerebral Infarction / Q000000981:diagnostic imaging / Q000209:etiology; D005123:Eye / Q000098:blood supply*; D005500:Follow-Up Studies; D006801:Humans; D002537:Intracranial Arteriosclerosis / Q000150:complications; D002542:Intracranial Embolism and Thrombosis / Q000150:complications / Q000000981:diagnostic imaging*; D002546:Ischemic Attack, Transient / Q000000981:diagnostic imaging / Q000209:etiology; D008833:Microcirculation; D012008:Recurrence; D012171:Retinal Vessels; D012189:Retrospective Studies; D017585:Ultrasonography, Doppler, Transcranial