title: [Systematic analysis of basic drugs in plasma using X-5 solid-phase extraction GC-FID and GC-MS].
abstract: A systematic determination method for 34 basic drugs in human plasma is described. Drugs were extracted from plasma at pH 10 using X-5 resin as adsorbent, then identified and quantitated by capillary GC-FID and GC-MS. The detection limits for most drugs are in the range of 0.5-2.0 micrograms.ml-1. Precision and linearity of the method are satisfactory for clinical toxicological applications.
authors.affiliation: Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing.
authors.forename: F H
authors.initials: FH
authors.lastname: Qiu
authors.forename: L
authors.initials: L
authors.lastname: Liu
authors.forename: Y
authors.initials: Y
authors.lastname: Luo
authors.forename: F
authors.initials: F
authors.lastname: Liu
authors.forename: Y Q
authors.initials: YQ
authors.lastname: Lu
mesh_terms: D000701:Analgesics, Opioid / Q000097:blood*; D000929:Antidepressive Agents, Tricyclic / Q000097:blood*; D014150:Antipsychotic Agents / Q000097:blood*; D002110:Caffeine / Q000097:blood; D000697:Central Nervous System Stimulants / Q000097:blood; D002849:Chromatography, Gas / Q000379:methods; D003975:Diazepam / Q000097:blood; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D006993:Hypnotics and Sedatives / Q000097:blood; D008614:Meperidine / Q000097:blood*; D010640:Phenothiazines
chemical_list: D000701:Analgesics, Opioid; D000929:Antidepressive Agents, Tricyclic; D014150:Antipsychotic Agents; D000697:Central Nervous System Stimulants; D006993:Hypnotics and Sedatives; D010640:Phenothiazines; D002110:Caffeine; D008614:Meperidine; D003975:Diazepam