title: Cutaneous involvement in children with acute lymphoblastic leukemia or lymphoblastic lymphoma. The Children's Leukemia Cooperative Group of the European Organization of Research and Treatment of Cancer (EORTC).
abstract: OBJECTIVE
  Skin involvement in children with acute monocytic leukemia or CD30-positive anaplastic large-cell lymphoma is well-known. In contrast, very little is known about the malignant cutaneous infiltrates in children with acute lymphoblatic leukemia (ALL) or lymphoblastic lymphoma (LBL). This study was designed to determine the frequency of these specific lesions in childhood ALL or LBL and the characteristics of such patients.
  
  
  METHODS
  We studied the clinical and biological findings of children with cutaneous involvement at initial diagnosis of ALL or LBL enrolled between August 1989 and March 1995 in the multicentric trial 58881 of the Children's Leukemia Cooperative Group of the European Organization of Research and Treatment of Cancer (EORTC).
  
  
  RESULTS
  Among the 1359 children enrolled in the multicenter trial EORTC 58881, 24 presented with skin involvement at diagnosis. ALL was diagnosed in 15 patients and LBL in 9. In 15 cases, skin lesions were observed within a median time of 6 weeks (range, a few days to 8 months) before the diagnosis of the hematologic disease. Twenty-one children had at least one skin lesion located on the head. Diffuse cutaneous lesions were observed in 7 infants with high-risk ALL. Seventeen of the 24 children remain in the first complete remission (median follow-up of 3 years; range 2 months to 5 years) and 3 are in the second remission with a follow-up of 14 to 24 months.
  
  
  CONCLUSIONS
  The present study demonstrates that cutaneous involvement can be an early manifestation of ALL or LBL. Cutaneous leukemic infiltrates can be observed in children with standard risk as well as in high-risk ALL. Cutaneous involvement in children with LBL is mainly associated with a B-cell precursor immunophenotype of the lymphomatous cells. The most frequent location of skin lesions in children with ALL or LBL is on the head. Further studies are needed to evaluate the prognosis of children with such involvement at diagnosis.
authors.affiliation: Department of Hematology, University Hospital of Poitiers, France.
authors.forename: F
authors.initials: F
authors.lastname: Millot
authors.forename: A
authors.initials: A
authors.lastname: Robert
authors.forename: Y
authors.initials: Y
authors.lastname: Bertrand
authors.forename: F
authors.initials: F
authors.lastname: Mechinaud
authors.forename: G
authors.initials: G
authors.lastname: Laureys
authors.forename: A
authors.initials: A
authors.lastname: Ferster
authors.forename: P
authors.initials: P
authors.lastname: Brock
authors.forename: P
authors.initials: P
authors.lastname: Rohrlich
authors.forename: F
authors.initials: F
authors.lastname: Mazingue
authors.forename: D
authors.initials: D
authors.lastname: Plantaz
authors.forename: E
authors.initials: E
authors.lastname: Plouvier
authors.forename: H
authors.initials: H
authors.lastname: Pacquement
authors.forename: C
authors.initials: C
authors.lastname: Behar
authors.forename: X
authors.initials: X
authors.lastname: Rialland
authors.forename: J M
authors.initials: JM
authors.lastname: Chantraine
authors.forename: F
authors.initials: F
authors.lastname: Guilhot
authors.forename: J
authors.initials: J
authors.lastname: Otten
mesh_terms: D000367:Age Factors; D001402:B-Lymphocytes / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006258:Head and Neck Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000276:immunology; D006801:Humans; D016130:Immunophenotyping; D007223:Infant; D007231:Infant, Newborn; D007621:Karyotyping; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis / Q000235:genetics / Q000276:immunology; D012307:Risk Factors; D012878:Skin Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000276:immunology; D013997:Time Factors