title: Diffuse alveolar hemorrhage associated with proteinase 3-specific anti-neutrophil cytoplasmic antibodies.
abstract: A 31-year-old man was referred to our hospital for the management of progressive diffuse alveolar hemorrhage associated with renal dysfunction. Leukocytoclastic vasculitis was shown by skin biopsy and crescentic glomerulonephritis was also detected, in addition to positivity for proteinase 3-specific anti-neutrophil cytoplasmic antibodies (PR3-ANCA). The patient was diagnosed as a rare case of PR3-ANCA-positive pulmonary-renal vasculitic syndrome without granulomatous lesions. There was a good response to combination therapy with steroids and cyclophosphamide.
authors.affiliation: First Department of Internal Medicine, Tokyo Medical College.
authors.forename: M
authors.initials: M
authors.lastname: Kikawada
authors.forename: Y
authors.initials: Y
authors.lastname: Ichinose
authors.forename: K
authors.initials: K
authors.lastname: Minemura
authors.forename: A
authors.initials: A
authors.lastname: Kunisawa
authors.forename: H
authors.initials: H
authors.lastname: Kusumoto
authors.forename: S
authors.initials: S
authors.lastname: Okabe
authors.forename: M
authors.initials: M
authors.lastname: Yonemaru
authors.forename: M
authors.initials: M
authors.lastname: Ogura
authors.forename: T
authors.initials: T
authors.lastname: Nakao
authors.forename: Y
authors.initials: Y
authors.lastname: Ebihara
authors.forename: K
authors.initials: K
authors.lastname: Toyama
mesh_terms: D000328:Adult; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000097:blood*; D001324:Autoantigens; D003520:Cyclophosphamide / Q000627:therapeutic use; D005921:Glomerulonephritis / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy; D006470:Hemorrhage / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology*; D006801:Humans; D008171:Lung Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology*; D008297:Male; D053146:Myeloblastin; D011650:Pulmonary Alveoli; D012697:Serine Endopeptidases / Q000276:immunology*; D013256:Steroids / Q000627:therapeutic use; D013577:Syndrome; D014657:Vasculitis / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic; D001324:Autoantigens; D013256:Steroids; D003520:Cyclophosphamide; D012697:Serine Endopeptidases; D053146:Myeloblastin