Gender differences of inducible nitric oxide production in SJL/J mice with experimental autoimmune encephalomyelitis.
We identified gender related differences of inducible nitric oxide synthase (iNOS) expression and NO production in mice with experimental autoimmune encephalomyelitis (EAE). When myelin basic protein-specific T-lymphocytes derived from female mice were transferred, the female recipients developed more severe EAE and expressed higher levels of iNOS and NO than male recipients. When the T-lymphocytes derived from males were transferred, severe EAE was induced in neither female or male recipients and neither iNOS nor NO were detectable. These data show an association between No production and EAE severity, suggesting a possible role of NO in the pathogenesis of EAE.
Ding
M
M
Department of Neurology, School of Medicine, University of California, Los Angeles 90095, USA. mding@ucla.edu
Wong
J L
JL
Rogers
N E
NE
Ignarro
L J
LJ
Voskuhl
R R
RR
D000818:Animals; D015152:Blotting, Northern; D001921:Brain / Q000201:enzymology / Q000276:immunology; D003563:Cyclic CMP / Q000096:biosynthesis / Q000378:metabolism; D004195:Disease Models, Animal; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology / Q000378:metabolism*; D005260:Female; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009103:Multiple Sclerosis / Q000276:immunology / Q000378:metabolism; D009569:Nitric Oxide / Q000096:biosynthesis* / Q000276:immunology / Q000378:metabolism; D019001:Nitric Oxide Synthase / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism; D012727:Sex Characteristics; D013116:Spinal Cord / Q000201:enzymology / Q000276:immunology
D012333:RNA, Messenger; D009569:Nitric Oxide; D003563:Cyclic CMP; D019001:Nitric Oxide Synthase