[The effect of radiation from videoterminal of personal computer on spontaneous and estradiol dipropionate-induced carcinogenesis in mice].
Two series of experiments using female mice SHR were conducted. In the first run, the animals were exposed to radiation from a video display terminal of a personal computer (VDT), for 1 hr, 5 times a week, starting at the age of 3 months. The treatment continued until their natural death, with and without an Ergostar protective screen filter (SF). During the second run, mice were injected either 10 mkg estradiol-dipropionate (ED), subcutaneously, with 0.1 ml olive oil, or the same dose of olive oil. Beginning from the first injection of either substance, the mice started to receive VDT radiation like those of the first series did. The frequency of persistent estrus appeared to be significantly higher in the first group, irrespective of whether SF was used. The latter factor had virtually no bearing on tumor incidence rate and tumor latency period in this experiment. However, experiment 2 established a noticeable increase in incidence of mammary and ovarian tumors matched by a shorter latency period in ED- and VDT-treated animals as compared with intact controls. At the same time, mice exposed to ED and VDT+SF revealed fewer tumors of the reproductive system. It was suggested that there is no relationship between exposure to VDT and spontaneous tumorigenesis, irrespective of whether SF is used or not. However, exposure to VDT may slightly promote development of ED-induced tumors, while application of SF may moderate the process.
Muratov
E I
EI
Zabezhinskiĭ
M A
MA
Popovich
I G
IG
Anisimov
V N
VN
D000818:Animals; D016288:Computer Terminals; D004958:Estradiol / Q000031:analogs & derivatives; D005260:Female; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced / Q000209:etiology*; D051379:Mice; D008812:Mice, Hairless; D008838:Microcomputers; D010051:Ovarian Neoplasms / Q000139:chemically induced / Q000209:etiology*; D011482:Protective Devices; D013997:Time Factors
D004958:Estradiol; C023482:estradiol dipropionate