title: Prevalence of anti-FVIII antibodies in severe haemophilia A patients with inversion of intron 22.
abstract: The aim of our study was to investigate whether haemophilia A patients with inversion of intron 22 are at high risk for non-inhibitory anti-FVIII antibodies development detected by ELISA. It is known that patients with severe forms of haemophilia A are more likely to develop anti-FVIII antibodies. The incidence of inhibitory anti-FVIII antibodies in patients with factor VIII gene inversion has been extensively evaluated, but if this defect has to be considered a predisposing factor is still debatable. Non-inhibitory anti-FVIII antibodies are attracting interest, due to the potential influence on FVIII half-life. Our data show that FVIII gene inversion was a major predisposing factor for anti-FVIII antibodies development.
authors.affiliation: Institute of Medical Semeiotics, University of Padua Medical School, Padova, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Vianello
authors.forename: P
authors.initials: P
authors.lastname: Radossi
authors.forename: T
authors.initials: T
authors.lastname: Tison
authors.forename: F
authors.initials: F
authors.lastname: Dazzi
authors.forename: G
authors.initials: G
authors.lastname: Tagariello
authors.forename: P G
authors.initials: PG
authors.lastname: Davoli
authors.forename: A
authors.initials: A
authors.lastname: Girolami
mesh_terms: D000293:Adolescent; D000328:Adult; D000906:Antibodies / Q000032:analysis* / Q000235:genetics; D007446:Chromosome Inversion; D004797:Enzyme-Linked Immunosorbent Assay; D005169:Factor VIII / Q000235:genetics / Q000276:immunology*; D006467:Hemophilia A / Q000235:genetics / Q000276:immunology*; D006801:Humans; D007438:Introns / Q000276:immunology*; D008875:Middle Aged; D012307:Risk Factors
chemical_list: D000906:Antibodies; D005169:Factor VIII