MRI of pituitary adenomas in acromegaly.
Adenomas causing acromegaly represent at least a quarter of pituitary adenomas. We studied 12 patients presenting with active acromegaly due to a pituitary adenoma with a 1.5 T superconductive MRI unit. All had T1-weighted sagittal and coronal sections before and after Gd-DTPA; six had coronal T2-weighted images. Surgical correlation was obtained in seven patients. Histologically, there were eight growth hormone (GH)-secreting and three mixed [GH and prolactin (PRL) secreting] adenomas, and one secreting GH, PRL and follicle-stimulating hormone. Macroadenomas (10) were more frequent than microadenomas (2). No correlation was found between serum GH and tumour size. There were nine adenomas in the lateral part of the pituitary gland; seven showed lateral or infrasellar invasion. Homogeneous, isointense signal on T1- and T2-weighted images was observed in six cases. Heterogeneous adenomas had cystic or necrotic components.
Marro
B
B
Service de Neuroradiologie, Bâtiment Babinsky, Hôpital Salpetrière, Paris, France.
Zouaoui
A
A
Sahel
M
M
Crozat
N
N
Gerber
S
S
Sourour
N
N
Sag
K
K
Marsault
C
C
D000172:Acromegaly / Q000175:diagnosis* / Q000473:pathology; D000236:Adenoma / Q000175:diagnosis* / Q000473:pathology; D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D003287:Contrast Media; D005260:Female; D005640:Follicle Stimulating Hormone / Q000378:metabolism; D019786:Gadolinium DTPA; D019382:Human Growth Hormone / Q000378:metabolism; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009942:Organometallic Compounds; D009384:Paraneoplastic Endocrine Syndromes / Q000175:diagnosis* / Q000473:pathology; D004369:Pentetic Acid / Q000031:analogs & derivatives; D010902:Pituitary Gland / Q000473:pathology; D010911:Pituitary Neoplasms / Q000175:diagnosis* / Q000473:pathology; D015175:Prolactinoma / Q000175:diagnosis / Q000473:pathology
D003287:Contrast Media; D009942:Organometallic Compounds; D019382:Human Growth Hormone; D004369:Pentetic Acid; D005640:Follicle Stimulating Hormone; D019786:Gadolinium DTPA