Serum levels of soluble form of Fas molecule in patients with congestive heart failure.
Compared with soluble Fas molecule (sFas, an inhibitor of Fas-mediated apoptosis) in normal volunteers, the serum level of sFas significantly increased by 41% in New York Heart Association (NYHA) class III (p <0.05) and by 97% in NYHA class IV patients with congestive heart failure (p <0.001). Furthermore, sFas showed correlations with soluble forms of TNF receptor-p55 (RI) and -p75 (RII) (r = 0.68 and r = 0.56) which inhibit activities of TNF alpha.
Okuyama
M
M
The First Department of Internal Medicine, Yamagata University Medical School, Japan.
Yamaguchi
S
S
Nozaki
N
N
Yamaoka
M
M
Shirakabe
M
M
Tomoike
H
H
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006333:Heart Failure / Q000097:blood* / Q000145:classification / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D008970:Molecular Weight; D018124:Receptors, Tumor Necrosis Factor / Q000097:blood; D019014:fas Receptor / Q000097:blood*
D018124:Receptors, Tumor Necrosis Factor; D019014:fas Receptor