Reversible inhibition of enzymatic systems involving covalent intermediates.
Reversible inhibition phenomena are analyzed for enzymatic systems involving covalent intermediates, where the inhibitor can bind to the pure enzyme, the Henri-Michaelis complex or the covalent intermediate, or to two or three of these enzyme forms. Classical competitive, non-competitive or un-competitive phenomena can be observed in some cases but unexpected features are also observed. Complex phenomena sometimes prevail where increased kcat/Km values can be accompanied by decreased or increased kcat values.
Zhao
G H
GH
Centre d'Ingénierie des Protéines and Laboratoire d'Enzymologie, Institut de Chimie, B6, Université de Liège au Sart Tilman, Belgium.
Frère
J M
JM
D001667:Binding, Competitive; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D004798:Enzymes / Q000737:chemistry* / Q000378:metabolism*; D007700:Kinetics; D008956:Models, Chemical
D004791:Enzyme Inhibitors; D004798:Enzymes