Multifocal osteosarcoma in a patient with Fanconi anemia.
OBJECTIVE
The purpose of this report is to present a case of multifocal osteosarcoma in a patient with Fanconi anemia.


METHODS
A nine year old girl with known Fanconi anemia presented with a pathologic femur fracture. Imaging studies confirmed soft tissue and bony involvement in the femur, ipsilateral tibia, and possibly contralateral femur.


RESULTS
Biopsy and subsequent amputation confirmed the presence of classic osteosarcoma in the involved femur and ipsilateral tibia. The patient died seven months later of pulmonary failure secondary to metastases.


CONCLUSIONS
Fanconi anemia is known to be associated with malignancies such as leukemias. We report a new association of Fanconi anemia with osteosarcoma.
Levinson
S
S
Oregon Health Sciences University, Portland, USA.
Vincent
K A
KA
D001859:Bone Neoplasms / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D002648:Child; D005199:Fanconi Anemia / Q000150:complications*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000556:secondary; D012516:Osteosarcoma / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D011859:Radiography