Is Creutzfeldt-Jakob disease transmitted in blood?
Creutzfeldt-Jakob disease (CJD) has been considered infectious since the mid-1960s, but its transmissibility through the transfusion of blood or blood products is controversial. The causative agent's novel undefined nature and resistance to standard decontamination, the absence of a screening test, and the recognition that even rare cases of transmission may be unacceptable have led to the revision of policies and procedures worldwide affecting all facets of blood product manufacturing from blood collection to transfusion. We reviewed current evidence that CJD is transmitted through blood.
Ricketts
M N
MN
Bureau of Infectious Diseases, Laboratory Centre for Disease Control, Ottawa, Ontario, Canada. mricketts@hpb.hwc.ca
Cashman
N R
NR
Stratton
E E
EE
ElSaadany
S
S
D000818:Animals; D016022:Case-Control Studies; D015331:Cohort Studies; D007562:Creutzfeldt-Jakob Syndrome / Q000635:transmission*; D006801:Humans; D065227:Transfusion Reaction