[The mRNA expression of CD2, CD4 and CD8 in peripheral blood lymphocytes from the patients with acute lymphoblastic leukemia and non-Hodgkin's lymphoma].
The paper for the first time reports the detection of the levels of CD2, CD4 and CD8 mRNA expression in peripheral blood lymphocytes from 9 cases with T-acute lymphoblastic leukemia (ALL) and 10 cases with T-non-Hodgkin's lymphoma (NHL) by using RNA dot blotting technique. It was found that the levels of CD2 mRNA in the two groups of patients were significantly higher than those in the normals. The ratios of the CD4 to CD8 mRNA were also increased in patients with NHL. The significance of this study was discussed.
Zhang
Z
Z
Institute of Basic Medical Sciences, CAMS, Beijing.
Xu
C
C
Liu
S
S
Zheng
D
D
Li
S
S
D000328:Adult; D018801:CD2 Antigens / Q000235:genetics*; D015704:CD4 Antigens / Q000235:genetics; D016516:CD4-CD8 Ratio; D016827:CD8 Antigens / Q000235:genetics; D005260:Female; D006801:Humans; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000276:immunology*; D016399:Lymphoma, T-Cell / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D012333:RNA, Messenger / Q000378:metabolism*
D018801:CD2 Antigens; D015704:CD4 Antigens; D016827:CD8 Antigens; D012333:RNA, Messenger