[Effect of dihydroetorphini hydrochloride on mice parturition].
OBJECTIVE
To determine the effect of dihydroetorphini hydrochloride (DHE) on parturition of mice.


METHODS
180 pregnant mice were divided equally into 6 groups. DHE was administered intramuscularly (i.m.) to mice group A, B and C at the dose levels of 1, 2 and 4 micrograms/kg respectively. Morphine hydrochloride 200 micrograms/kg (hypodermic) was given to group D and procaine hydrochloride 1000 micrograms/kg i.m. for group E, while for group F as control distilled water was given. Each preparation was given to the pregnant mice 3 times, i.e. 18 hours before the date of confinement, during labor and 2 hours postpartum.


RESULTS
No effects on mice parturition were found in group A, B, E, and F. The percentage of cyanosis in newborn mice of group C and D was 13.8% and 22.8% respectively, which was significantly higher than that (7.4%) in group F.


CONCLUSIONS
DHE is safer than morphine and procaine for analgesia during labor, and no adverse effects of DHE at dose levels of 1 microgram/kg and 2 micrograms/kg were observed on mice parturition.
Wang
A
A
Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing.
Zhang
Q
Q
Huang
C
C
D015746:Abdominal Pain / Q000517:prevention & control; D000701:Analgesics, Opioid / Q000494:pharmacology*; D000779:Anesthetics, Local / Q000494:pharmacology; D000818:Animals; D005048:Etorphine / Q000031:analogs & derivatives* / Q000494:pharmacology; D005260:Female; D007743:Labor, Obstetric / Q000187:drug effects*; D051379:Mice; D009020:Morphine / Q000494:pharmacology; D011247:Pregnancy; D011343:Procaine / Q000494:pharmacology
D000701:Analgesics, Opioid; D000779:Anesthetics, Local; D005048:Etorphine; D011343:Procaine; D009020:Morphine; C034765:18,19-dihydroetorphine