title: Scan findings of various myocardial SPECT agents in a case of amyloid polyneuropathy with suspected myocardial involvement.
abstract: A 31-year-old male having familial amyloid polyneuropathy underwent a Tc-99m(V)-DMSA study to evaluate the myocardial involvement. The patient also underwent T1-201, I-123-BMIPP and I-123-MIBG myocardial SPECT studies to evaluate blood perfusion, fatty acid metabolism and sympathetic function of the heart, respectively. Tc-99m(V)-DMSA SPECT showed uptake to the myocardium indicating myocardial involvement of amyloidosis. Both T1-201 and I-123-BMIPP studies showed normal uptake indicating normal blood perfusion and fatty acid metabolism but I-123-MIBG SPECT showed no uptake to the heart, indicating severe impairment of sympathetic function.
authors.affiliation: Department of Radiology, Yamanashi Medical University, Japan. saali@res.yamanashi-med.ac.jp
authors.forename: A S
authors.initials: AS
authors.lastname: Arbab
authors.forename: K
authors.initials: K
authors.lastname: Koizumi
authors.forename: K
authors.initials: K
authors.lastname: Toyama
authors.forename: T
authors.initials: T
authors.lastname: Arai
authors.forename: T
authors.initials: T
authors.lastname: Yoshitomi
authors.forename: T
authors.initials: T
authors.lastname: Araki
mesh_terms: D019797:3-Iodobenzylguanidine; D000328:Adult; D017772:Amyloid Neuropathies / Q000000981:diagnostic imaging*; D000686:Amyloidosis / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000503:physiopathology; D009202:Cardiomyopathies / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000503:physiopathology; D003326:Coronary Circulation; D005227:Fatty Acids / Q000378:metabolism; D006801:Humans; D007457:Iodine Radioisotopes; D007462:Iodobenzenes; D008297:Male; D015609:Organotechnetium Compounds; D004113:Succimer; D019783:Technetium Tc 99m Dimercaptosuccinic Acid; D013794:Thallium Radioisotopes; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*
chemical_list: D005227:Fatty Acids; D007457:Iodine Radioisotopes; D007462:Iodobenzenes; D015609:Organotechnetium Compounds; D013794:Thallium Radioisotopes; C049338:iodofiltic acid; D019797:3-Iodobenzylguanidine; D019783:Technetium Tc 99m Dimercaptosuccinic Acid; D004113:Succimer