Transient down-regulation of inhibin-betaC expression following partial hepatectomy.
Inhibin-betaC is a recently described TGF-beta family member most homologous to inhibin-betaA and inhibin-betaB. By Northern analysis, inhibin-betaC mRNA was detected exclusively in the liver among a large number of adult mouse tissues surveyed. The expression of inhibin-betaC mRNA in adult liver dropped sharply and transiently following partial hepatectomy. At 6 and 12 hours following partial hepatectomy, the levels of inhibin-betaC mRNA were at least 8-fold lower than in control animals. The liver specificity of inhibin-betaC expression and its down-regulation following partial hepatectomy suggest that inhibin-betaC may function as a negative regulator of liver growth.
Esquela
A F
AF
Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
Zimmers
T A
TA
Koniaris
L G
LG
Sitzmann
J V
JV
Lee
S J
SJ
D000818:Animals; D005260:Female; D015971:Gene Expression Regulation, Enzymologic; D006498:Hepatectomy; D007265:Inhibins / Q000096:biosynthesis; D007700:Kinetics; D008099:Liver / Q000378:metabolism*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009928:Organ Specificity; D010452:Peptide Biosynthesis; D029584:Prostatic Secretory Proteins
D029584:Prostatic Secretory Proteins; C043076:beta-microseminoprotein; D007265:Inhibins