[The metabolism and bactericidal properties of the blood neutrophilic granulocytes in experimental typhoid intoxication].
The levels of succinate dehydrogenase (SDG), lactate dehydrogenase (LDG), glucose-6-phosphate-dehydrogenase (G-6-PDG), myeloperoxydase (MPO), glycogen and cationic proteins were determined in the neutrophilic granulocytes of peripheral blood of 79 rabbits after experimental contamination by endotoxin of S. typhi. The bactericidal system of neutrophils was stimulated due to the depression of SDG, activation of LDG and G-6-PDG levels. Administration of indometacinum and chlotasolum blockaded the cyclooxygenase fermentative system of prostaglandin synthesis and thus decreased the activity of S. typhi endotoxin.
Ovcharenko
N I
NI
Borisova
M A
MA
Shpak
S I
SI
Danilesku
A E
AE
Krivosheev
V N
VN
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000493:pharmacokinetics; D001770:Blood Bactericidal Activity; D002697:Chloral Hydrate / Q000493:pharmacokinetics; D016861:Cyclooxygenase Inhibitors / Q000493:pharmacokinetics; D006651:Histocytochemistry; D007213:Indomethacin / Q000493:pharmacokinetics; D008297:Male; D009504:Neutrophils / Q000276:immunology* / Q000378:metabolism*; D011817:Rabbits; D013844:Thiazoles / Q000493:pharmacokinetics; D013997:Time Factors; D014435:Typhoid Fever / Q000097:blood* / Q000276:immunology*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D016861:Cyclooxygenase Inhibitors; D013844:Thiazoles; D002697:Chloral Hydrate; C034140:chlotazol; D007213:Indomethacin