title: Systolic function impairment in higher erythropoietin requirement patients in hemodialysis.
abstract: Circulatory adaptation to hemodialysis (HD) depends on several inter-related factors, due to the particular patient and to technical procedures. The cardiac effects of nutritional status and the improvement that erythropoietin (r-HuEPO) treatment, through the reduction of anemia, can determine, were reported; r-HuEPO requirements are quite different, in different patients, while achieving similar haemoglobin end-point. Thirty-four patients on r-HuEPO and 11 patients not treated, all in hemodialysis, were studied by echocardiography at beginning and at the end of 3 consecutive dialysis sessions. Ejection fraction increased with hemodialysis in all patients of the control group. A slight and not significant decrease of ejection fraction was observed, as average, in the r-HuEPO treated patients. But, more in detail, 20 patients on r-HuEPO showed a worsening of systolic function with hemodialysis; in the other 14 patients on r-HuEPO, as in not treated control patients, systolic function improved. A significant difference between the two sub-groups on r-HuEPO was the higher drug dose requirement, associated with a slightly lower haemoglobin concentration, both observed in patients with decreased ejection fraction after hemodialysis. Moreover, a close relationship between higher r-HuEPO requirements and worsening of systolic function was observed. This trend is not associated with adequacy of dialysis and malnutrition. Patients with higher r-HuEPO requirement share a worse cardiac adaptation to hemodialysis and slightly lower haemoglobin levels.
authors.affiliation: Istituto di Medicina Interna e Terapia Medica, Università, Catania.
authors.forename: G M
authors.initials: GM
authors.lastname: Trovato
authors.forename: E
authors.initials: E
authors.lastname: Iannetti
authors.forename: G
authors.initials: G
authors.lastname: Carpinteri
mesh_terms: D000222:Adaptation, Physiological / Q000187:drug effects; D000368:Aged; D000740:Anemia / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology; D004452:Echocardiography; D004921:Erythropoietin / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011994:Recombinant Proteins; D006435:Renal Dialysis / Q000009:adverse effects / Q000706:statistics & numerical data; D013318:Stroke Volume / Q000187:drug effects; D013599:Systole / Q000187:drug effects; D018754:Ventricular Dysfunction / Q000000981:diagnostic imaging / Q000503:physiopathology*
chemical_list: D011994:Recombinant Proteins; D004921:Erythropoietin