title: Lipohexin, a new inhibitor of prolyl endopeptidase from Moeszia lindtneri (HKI-0054) and Paecilomyces sp. (HKI-0055; HKI-0096). I. Screening, isolation and structure elucidation.
abstract: Lipohexin was isolated as a novel lipohexapeptide (I) (C39H68N6O9) from three fungal strains, Moeszia lindtneri HKI-0054, Paecilomyces sp. HKI-0055 and Paecilomyces sp. HKI-0096. The structure was elucidated by detailed mass spectrometric and NMR experiments. The proline-containing peptide displays moderate antibacterial activity against Bacillus subtilis ATCC 6633 and inhibits competitively the prolyl endopeptidase from human placenta.
authors.affiliation: Hans-Knöll-Institute of Natural Products Research, Jena, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Heinze
authors.forename: M
authors.initials: M
authors.lastname: Ritzau
authors.forename: W
authors.initials: W
authors.lastname: Ihn
authors.forename: H
authors.initials: H
authors.lastname: Hülsmann
authors.forename: B
authors.initials: B
authors.lastname: Schlegel
authors.forename: K
authors.initials: K
authors.lastname: Dornberger
authors.forename: W F
authors.initials: WF
authors.lastname: Fleck
authors.forename: M
authors.initials: M
authors.lastname: Zerlin
authors.forename: C
authors.initials: C
authors.lastname: Christner
authors.forename: U
authors.initials: U
authors.lastname: Gräfe
authors.forename: G
authors.initials: G
authors.lastname: Küllertz
authors.forename: G
authors.initials: G
authors.lastname: Fischer
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001412:Bacillus subtilis / Q000187:drug effects; D006801:Humans; D008074:Lipoproteins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D003904:Mitosporic Fungi / Q000378:metabolism; D015394:Molecular Structure; D010143:Paecilomyces / Q000378:metabolism; D010455:Peptides; D000085822:Prolyl Oligopeptidases; D012697:Serine Endopeptidases / Q000378:metabolism*; D015842:Serine Proteinase Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D008074:Lipoproteins; D010455:Peptides; D015842:Serine Proteinase Inhibitors; C107025:lipohexin; D012697:Serine Endopeptidases; C000705287:PREPL protein, human; D000085822:Prolyl Oligopeptidases