title: Antimutagenesis and anticancer effects.
abstract: Cancer development is a multistage process wherein mutational events play an important role. Various antimutagen components, in particular magnesium and selenium, have been reported to have anticarcinogenic properties. These two oligoelements display different behaviors according to their concentrations. The different effects of magnesium and selenium depend on the different mechanisms of cell absorption. The importance of antimutagenesis studies in cancer prevention is reported and a review of the basic mechanisms operative in antimutagenesis, including some data on known antimutagens, is made.
authors.affiliation: Istituto di Mutagenesi e Differenziamento, Centro Nazionale delle Ricerche, Pisa, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Bronzetti
authors.forename: C
authors.initials: C
authors.lastname: Della Croce
authors.forename: P
authors.initials: P
authors.lastname: Aretini
authors.forename: R
authors.initials: R
authors.lastname: Fiorio
mesh_terms: D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D016587:Antimutagenic Agents / Q000494:pharmacology*; D002273:Carcinogens / Q000037:antagonists & inhibitors*; D006801:Humans; D016296:Mutagenesis / Q000187:drug effects*; D009369:Neoplasms / Q000517:prevention & control*; D009374:Neoplasms, Experimental / Q000517:prevention & control
chemical_list: D016588:Anticarcinogenic Agents; D016587:Antimutagenic Agents; D002273:Carcinogens