title: [Rhinovirus infection and expression of adhesion molecules in human tracheal epithelium].
abstract: Rhinovirus infection has attracted attention because it can lead to acute exacerbations of chronic inflammatory airway diseases such as bronchial asthma and chronic bronchitis. We established a culture system and inoculated human rhinovirus to human tracheal epithelial cells, and found that infection was augmented by up-regulation of intercellular adhesion molecule-1, which is the receptor for this virus. We also found that human airway epithelial cells infected with rhinovirus were susceptible to a chemical oxidant (H2O2) released by inflammatory cells, which would contribute to acute exacerbations of inflammatory airway diseases. Finally, we found that anti-ICAM-1 antibodies or dexamethasone can inhibit the infectivity to rhinovirus by suppressing ICAM-1, and diminish susceptibility to oxidants in the cultured human tracheal epithelium.
authors.affiliation: Department of Geriatric Medicine, Tohoku University School of Medicine, Sendai, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Ohrui
authors.forename: M
authors.initials: M
authors.lastname: Yamaya
authors.forename: K
authors.initials: K
authors.lastname: Sekizawa
authors.forename: M
authors.initials: M
authors.lastname: Terajima
authors.forename: N
authors.initials: N
authors.lastname: Yamada
authors.forename: T
authors.initials: T
authors.lastname: Suzuki
authors.forename: S
authors.initials: S
authors.lastname: Okinaga
authors.forename: H
authors.initials: H
authors.lastname: Hoshi
authors.forename: H
authors.initials: H
authors.lastname: Suzuki
authors.forename: H
authors.initials: H
authors.lastname: Sasaki
mesh_terms: D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D002478:Cells, Cultured; D016207:Cytokines / Q000494:pharmacology / Q000502:physiology; D003907:Dexamethasone / Q000494:pharmacology; D004848:Epithelium / Q000821:virology; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000378:metabolism*; D016877:Oxidants / Q000378:metabolism; D012229:Rhinovirus / Q000502:physiology*; D014132:Trachea / Q000378:metabolism / Q000821:virology*; D014779:Virus Replication / Q000187:drug effects
chemical_list: D000893:Anti-Inflammatory Agents; D016207:Cytokines; D016877:Oxidants; D018799:Intercellular Adhesion Molecule-1; D003907:Dexamethasone