Types of mutations induced by glyoxal, a major oxidative DNA-damage product, in Salmonella typhimurium.
We have analyzed the types of mutations induced by glyoxal, a major oxidative DNA-damage product, in Salmonella typhimurium. A set of six strains, TA7001 to TA7006, was used to detect base-pair substitutions, and the TA98 strain was employed to detect frameshift mutations. Glyoxal did not induce mutations at A:T base pairs. The majority of the mutations induced by glyoxal were base-pair substitutions at G:C base pairs, and a small level of frameshift mutations was detected in the TA98 strain.
Murata-Kamiya
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Department of Health Policy and Management, University of Occupational and Environmental Health, Kitakyushu, Japan.
Kaji
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Kasai
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H
D001482:Base Composition; D004249:DNA Damage; D016368:Frameshift Mutation; D006037:Glyoxal / Q000378:metabolism / Q000494:pharmacology*; D009152:Mutagenicity Tests; D009153:Mutagens; D009154:Mutation; D017382:Reactive Oxygen Species / Q000378:metabolism; D012486:Salmonella typhimurium / Q000187:drug effects* / Q000235:genetics*
D009153:Mutagens; D017382:Reactive Oxygen Species; D006037:Glyoxal