title: Spinal conduction block by intrathecal ketamine in dogs.
abstract: In addition to its use for intravenous (I.V.) anesthesia, ketamine can provide pain relief in humans when administered spinally. To elucidate the mechanisms of intrathecal (I.T.) ketamine analgesia, we observed differences in the effects of I.V. and I.T. ketamine on intraspinal evoked potentials (ISEPs) in 28 dogs anesthetized with pentobarbital. Bipolar extradural electrodes were inserted at the cervical and lumbar regions of the spinal cord for recording descending ISEPs represented by the two negative deflections, Waves I and II. I.V. ketamine 2 and 10 mg/ kg did not affect the amplitude and latency of Wave I, whereas the large dose (10 mg/kg) significantly decreased the amplitude but not the latency of Wave II. I.T. ketamine 1 and 5 mg/kg caused significant dose-dependent decreases in both Wave I and II amplitudes and prolongations of both Wave I and II latencies. These I.T. effects on ISEPs are consistent with previous in vitro observations that ketamine blocks axonal conduction. We conclude that axonal conduction block may contribute to the analgesic mechanism of I.T. ketamine.
authors.affiliation: Department of Anesthesiology and Critical Care Medicine, Gifu University School of Medicine, Gifu City, Japan. iida@cc.gifu-u.ac.jp
authors.forename: H
authors.initials: H
authors.lastname: Iida
authors.forename: S
authors.initials: S
authors.lastname: Dohi
authors.forename: T
authors.initials: T
authors.lastname: Tanahashi
authors.forename: Y
authors.initials: Y
authors.lastname: Watanabe
authors.forename: M
authors.initials: M
authors.lastname: Takenaka
mesh_terms: D000775:Anesthesia, Spinal; D000778:Anesthetics, Dissociative / Q000008:administration & dosage* / Q000494:pharmacology; D000818:Animals; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D005071:Evoked Potentials / Q000187:drug effects; D007275:Injections, Intravenous; D007278:Injections, Spinal; D007649:Ketamine / Q000008:administration & dosage* / Q000494:pharmacology; D009431:Neural Conduction / Q000187:drug effects*; D011930:Reaction Time / Q000187:drug effects; D013116:Spinal Cord / Q000502:physiology*
chemical_list: D000778:Anesthetics, Dissociative; D007649:Ketamine