Lack of correlation between conceptual karyotype and maternal response to placentation.
The placental karyotype was correlated with the morphology of the placental bed in miscarriages. Abnormal placentation was as likely to be seen in euploid conceptions as in aneuploid conceptions, whereas normal placentation was seen with both euploid and aneuploid pregnancies. No consistent chromosomal abnormality was found with abnormal placentation. Since abnormal placentation is implicated in the pathogenesis of preeclampsia and miscarriages, these findings may be useful with respect to the localization of a candidate 'preeclampsia gene' by identifying a specific chromosome associated with abnormal placentation.
Khong
T Y
TY
Department of Histopathology, Women's and Children's Hospital, North Adelaide, Australia.
Ford
J H
JH
D000022:Abortion, Spontaneous / Q000235:genetics* / Q000473:pathology; D002869:Chromosome Aberrations; D005260:Female; D005865:Gestational Age; D006801:Humans; D007621:Karyotyping; D010920:Placenta / Q000737:chemistry / Q000473:pathology*; D010929:Placentation / Q000502:physiology*; D011225:Pre-Eclampsia / Q000235:genetics; D011247:Pregnancy