title: Pertussis in The Netherlands: an outbreak despite high levels of immunization with whole-cell vaccine.
abstract: In 1996, a sudden increase in pertussis incidence was reported in the Netherlands (2.1 per 100,000 in 1995, 18 per 100,000 in 1996). Although not all potential surveillance artifacts could be excluded, it is highly probable that the data reflect a true outbreak. However, the cause of this increase has not yet been determined. Further research is directed to the severity of disease and a possible mismatch between the vaccine and the circulating Bordetella strains.
authors.affiliation: National Institute of Public Health and the Environment, Bilthoven, The Netherlands.
authors.forename: H E
authors.initials: HE
authors.lastname: de Melker
authors.forename: M A
authors.initials: MA
authors.lastname: Conyn-van Spaendonck
authors.forename: H C
authors.initials: HC
authors.lastname: Rümke
authors.forename: J K
authors.initials: JK
authors.lastname: van Wijngaarden
authors.forename: F R
authors.initials: FR
authors.lastname: Mooi
authors.forename: J F
authors.initials: JF
authors.lastname: Schellekens
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D004196:Disease Outbreaks; D006801:Humans; D007114:Immunization; D007223:Infant; D007231:Infant, Newborn; D008875:Middle Aged; D009426:Netherlands / Q000453:epidemiology; D010567:Pertussis Vaccine / Q000276:immunology*; D014917:Whooping Cough / Q000453:epidemiology* / Q000517:prevention & control
chemical_list: D010567:Pertussis Vaccine