title: Reversible MRI lesions after seizures.
abstract: After generalized or partial seizures, transient lesions may appear on magnetic resonance (MR) images. The mechanisms of MR changes might be a defect in cerebral autoregulation and blood-brain permeability. We report a patient with partial and secondary generalized tonic-clonic seizures. After her first seizure which was generalized tonic-clonic in nature, we detected multiple high signal intensities over the frontal cortical area on proton density images which were enhanced with gadolinium on T1-weighted images. The first and repeated EEGs showed no abnormalities or epileptic discharges. We started carbamezapine (600 mg/d) and excluded systemic diseases like vasculitis, infections, aetiological factors causing cerebrovascular diseases. In the follow-up, she was seizure free under antiepileptic therapy and no other neurological deficit. Repeated MR scans after 24 months from her first seizure revealed no pathologic signal intensities. Although the pathophysiology is unknown, recognition of reversible lesions helps diagnostic and therapeutic approaches to abnormal MR findings after seizures.
authors.affiliation: Department of Neurology, Marmara University School of Medicine, Istanbul, Turkey.
authors.forename: C
authors.initials: C
authors.lastname: Aykut-Bingol
authors.forename: S
authors.initials: S
authors.lastname: Tekin
authors.forename: D
authors.initials: D
authors.lastname: Ince
authors.forename: S
authors.initials: S
authors.lastname: Aktan
mesh_terms: D000328:Adult; D000927:Anticonvulsants / Q000627:therapeutic use; D002220:Carbamazepine / Q000627:therapeutic use; D002540:Cerebral Cortex / Q000473:pathology*; D004827:Epilepsy / Q000175:diagnosis* / Q000188:drug therapy; D005260:Female; D005625:Frontal Lobe / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D012640:Seizures / Q000175:diagnosis*
chemical_list: D000927:Anticonvulsants; D002220:Carbamazepine