title: Prevalence and clinical significance of hepatitis G virus infection in adult beta-thalassaemia major patients.
abstract: The risk of polytransfused patients for hepatitis C virus (HCV) infection is likely to extend to another recently identified member of the Flaviviridae, hepatitis G virus (HGV). We investigated the prevalence of HGV in 40 adult Italian patients with transfusion-dependent thalassaemia and evaluated the clinical significance of HGV infection. HGV-RNA was detected in 9/40 patients (22.5%). HGV infection was significantly associated with HCV viraemia (P = 0.0012), with all patients positive for HGV being also viraemic for HCV. Overall, the clinical picture of patients with HCV/HGV co-infection was not different from that of patients with isolated HCV. However, patients co-infected with both viruses had lower values of alanine-transferase (P = 0.035) and a lower titre of HCV viraemia (P = 0.042) in the absence of other evident factors which could influence the clinical expression of HCV infection. In conclusion, HGV is highly prevalent among Italian polytransfused patients. No evidence of a clinically significant pathogenic role for HGV in liver disease could be found in these patients. In a subset of cases a possible interference of HGV with HCV infection was observed.
authors.affiliation: Instituto di Medicina Interna e Fisiopatologia Medica, Universita di Milano and IRCCS Ospedale Maggiore Policlinico, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Sampietro
authors.forename: N
authors.initials: N
authors.lastname: Corbetta
authors.forename: M
authors.initials: M
authors.lastname: Cerino
authors.forename: P
authors.initials: P
authors.lastname: Fabiani
authors.forename: A
authors.initials: A
authors.lastname: Ticozzi
authors.forename: A
authors.initials: A
authors.lastname: Orlandi
authors.forename: G
authors.initials: G
authors.lastname: Lunghi
authors.forename: S
authors.initials: S
authors.lastname: Fargion
authors.forename: G
authors.initials: G
authors.lastname: Fiorelli
authors.forename: M D
authors.initials: MD
authors.lastname: Cappellini
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D018067:Flaviviridae; D006525:Hepatitis, Viral, Human / Q000209:etiology*; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D065227:Transfusion Reaction; D017086:beta-Thalassemia / Q000150:complications / Q000628:therapy*