Basic principles and techniques of pharmacokinetic modeling.
Pharmacokinetics has been extensively utilized to calculate safe and effective drug dosages for many exotic animals species. This practice is optimal when the complete pharmacokinetic profile is determined from an intravenous study in the target species. Extrapolation across species using allometric techniques also require precise yet robust intravenous pharmacokinetic data from the species for which the analyses is made. The report is an overview of the design and analysis of such pivotal pharmacokinetic experiments, taking into consideration the use of pilot studies to determine optimal sampling times, the true purpose of the study (determine model structure vs. estimating a known model's parameters), and strategies of data analysis. By following these simple guidelines, the exotic animal community should benefit by having reliable data on drug disposition for their species of interest.
Riviere
J E
JE
College of Veterinary Medicine, North Carolina State University, Raleigh 27606, USA.
D000818:Animals; D008954:Models, Biological; D004364:Pharmaceutical Preparations / Q000378:metabolism; D010599:Pharmacokinetics; D011485:Protein Binding; D013045:Species Specificity; D014730:Veterinary Medicine
D004364:Pharmaceutical Preparations