title: Cefepime versus ceftazidime in the treatment of lower respiratory tract infections.
abstract: The objective of the study was to compare the safety and efficacy of cefepime and ceftazidime in the treatment of community acquired lower respiratory tract infections of moderate intensity. Eighty-six patients were randomized at a 2:1 ratio to receive respectively cefepime 1 g b.i.d. or ceftazidime 1 g t.i.d. The drugs were well tolerated and the occurrence of adverse events in each group was comparable. The rates of satisfactory clinical response were 96% (49/51) for cefepime and 89% (24/27) for ceftazidime. A total of 73 pathogens were isolated and pathogen eradication rates were 98% and 96% respectively for the cefepime and ceftazidime treatment groups. In conclusion, the data confirmed that cefepime could be a good alternative to ceftazidime.
authors.affiliation: Divisione di Pneumologia, Ospedale E.Morelli, Sondalo, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Aufiero
authors.forename: C
authors.initials: C
authors.lastname: Sturani
authors.forename: P
authors.initials: P
authors.lastname: Zanon
authors.forename: A
authors.initials: A
authors.lastname: Marruchella
authors.forename: G
authors.initials: G
authors.lastname: Michetti
authors.forename: E
authors.initials: E
authors.lastname: Nicolin
authors.forename: D
authors.initials: D
authors.lastname: Sella
authors.forename: A
authors.initials: A
authors.lastname: Goglio
authors.forename: M
authors.initials: M
authors.lastname: Silleni
authors.forename: A
authors.initials: A
authors.lastname: La Regina
mesh_terms: D000368:Aged; D000077723:Cefepime; D002442:Ceftazidime / Q000009:adverse effects / Q000627:therapeutic use*; D002511:Cephalosporins / Q000009:adverse effects / Q000627:therapeutic use*; D017714:Community-Acquired Infections / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D012141:Respiratory Tract Infections / Q000188:drug therapy*
chemical_list: D002511:Cephalosporins; D000077723:Cefepime; D002442:Ceftazidime