title: 17alpha-Dihydroequilenin increases hippocampal dendritic spine density of ovariectomized rats.
abstract: The effects of estradiol and 17alpha-dihydroequilenin on the apical dendrite spine density of pyramidal cells of the CA1 region of rat hippocampus were compared. 17alpha-Dihydroequilenin was as effective as estradiol in increasing spine densities relative to controls. 17alpha-Dihydroequilenin is not uterotrophic like estradiol but does have beneficial effects on the cardiovascular system, suggesting that it may be an effective single-agent hormone replacement therapy to treat menopausal symptoms and reduce chronic disease risk in menopausal women.
authors.affiliation: Department of Obstetrics and Gynecology, Bowman Gray School of Medicine, Winston-Salem, NC 27157-1040, USA.
authors.forename: S A
authors.initials: SA
authors.lastname: Washburn
authors.forename: C E
authors.initials: CE
authors.lastname: Lewis
authors.forename: J E
authors.initials: JE
authors.lastname: Johnson
authors.forename: M L
authors.initials: ML
authors.lastname: Voytko
authors.forename: C A
authors.initials: CA
authors.lastname: Shively
mesh_terms: D000818:Animals; D002452:Cell Count / Q000187:drug effects*; D003712:Dendrites / Q000187:drug effects*; D004857:Equilin / Q000031:analogs & derivatives* / Q000494:pharmacology; D005260:Female; D006624:Hippocampus / Q000187:drug effects*; D010052:Ovariectomy; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D004857:Equilin; C014482:dihydroequilin