CD137, a member of the tumor necrosis factor receptor family, is located on chromosome 1p36, in a cluster of related genes, and colocalizes with several malignancies.
CD137 (ILA/4-1BB) is a member of the tumor-necrosis-factor receptor family. Members of this receptor family and their structurally related ligands are important regulators of a wide variety of physiological processes and play an especially important role in the regulation of immune responses. CD137 regulates cell proliferation and survival of T-lymphocytes. Using Southern blot analysis and polymerase chain reaction, we localized the CD137 gene to chromosome 1p36. This chromosomal region harbors the genes of several other members of this receptor family and is associated with deletions and rearrangements in several malignancies.
Schwarz
H
H
Department of Pathology, University of Regensburg, Germany.
Arden
K
K
Lotz
M
M
D002872:Chromosome Deletion; D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1; D003001:Cloning, Molecular; D015321:Gene Rearrangement; D006801:Humans; D006822:Hybrid Cells; D005810:Multigene Family; D009369:Neoplasms / Q000235:genetics* / Q000276:immunology; D016133:Polymerase Chain Reaction; D018124:Receptors, Tumor Necrosis Factor / Q000235:genetics; D012689:Sequence Homology, Nucleic Acid; D013601:T-Lymphocytes / Q000276:immunology
D018124:Receptors, Tumor Necrosis Factor