Differential prenatal toxicity of branched phthalate esters in rats.
Several phthalate esters with alcohol moieties ranging from C5-C10 chains were investigated for prenatal toxicity in 10 rats per group after gavage administration of 0, 40, 200 and 1000 mg/kg/day from gestation day 6 to 15. At 1000 mg/kg di(2-ethylhexyl) phthalate showed clear foetotoxicity, embryolethality and teratogenicity. No significant effects were recorded at 40 and 200 mg/kg. Di-711-phthalate, a phthalic ester with linear components and a predominantly alpha-methyl branching type, and di-isopentylphthalate showed a very similar spectrum of effects. Interestingly, the alcohol moiety of di-711-phthalate, 711-alcohol was developmentally inactive in a previous experiment. Di-iso-decylphthalate and three types of di-iso-nonylphthalate showed foetal effects of borderline significance at 1000 mg/kg/day.
Hellwig
J
J
Department of Toxicology, BASF Aktiengesellschaft, Ludwigshafen, Germany.
Freudenberger
H
H
Jäckh
R
R
D000014:Abnormalities, Drug-Induced; D000284:Administration, Oral; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004051:Diethylhexyl Phthalate / Q000008:administration & dosage / Q000633:toxicity; D005314:Embryonic and Fetal Development / Q000187:drug effects*; D004952:Esters; D005260:Female; D008098:Litter Size / Q000187:drug effects; D008297:Male; D019055:No-Observed-Adverse-Effect Level; D010795:Phthalic Acids / Q000008:administration & dosage / Q000633:toxicity*; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar; D015996:Survival Rate
D004952:Esters; D010795:Phthalic Acids; C012125:diisononyl phthalate; D004051:Diethylhexyl Phthalate; C042080:diisodecyl phthalate