A comparative study of high-fat diet containing fish oil or lard on blood glucose in genetically diabetic (db/db) mice.
The effects of high-fat diets containing fish oil or lard on blood glucose and plasma insulin after oral glucose loading were compared in genetically diabetic (db/db) mice, one of the animal models of non-insulin-dependent diabetes mellitus (NIDDM) with hyperinsulinemia. The blood glucose levels were significantly decreased in 27% of the mice fed high-fat diets containing 20% fish oil 30 and 60 min after the oral administration of glucose (both; p < 0.05). Conversely, the plasma insulin levels were significantly increased 30 min after the glucose loading as compared to 27% of the mice fed high-fat diets containing 20% lard (p < 0.01). In addition, a significant hypoglycemic effect was observed 60 min after the subcutaneous administration of insulin to mice on the fish oil diet (p < 0.05), whereas no effect was demonstrated in the case of those on the lard diet. The average body weight of the fish oil-treated mice was not significantly different from that of the lard-treated mice. The fish oil diet has a beneficial effect on glucose tolerance by increasing the insulin secretory capacity from pancreatic beta cells and also ameliorating insulin resistance.
Miura
T
T
Suzuka University of Medical Science and Technology, Mie, Japan.
Ohnishi
Y
Y
Takagi
S
S
Sawamura
M
M
Yasuda
N
N
Ishida
H
H
Tanigawa
K
K
Yamori
Y
Y
Seino
Y
Y
D000818:Animals; D001786:Blood Glucose / Q000032:analysis*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000235:genetics; D004041:Dietary Fats / Q000008:administration & dosage*; D004195:Disease Models, Animal; D005395:Fish Oils / Q000008:administration & dosage*; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D051379:Mice
D001786:Blood Glucose; D004041:Dietary Fats; D005395:Fish Oils; D007328:Insulin; C029310:lard