Serine/threonine kinase receptors and ligands.
Serine/threonine receptors transduce signals for the TGF-beta family, several members of which, such as decapentaplegic and bone morphogenetic proteins, are involved in early patterning of the embryo. The gene encoding the anti-Müllerian hormone (AMH) receptor has recently been cloned; gene targeting produces the same effects as targeting of the AMH gene itself. Another divergent member of the TGF-beta family, GDNF, signals through Ret, a tyrosine kinase receptor; binding to Ret requires the cooperation of GDNFR-alpha. The signal transduction pathway of serine/threonine receptors is now being intensively studied; the immunophilin FKBP-12 and MAD proteins are known to be involved.
Josso
N
N
INSERM, Ecole Normale Supérieure, Département de Biologie, Montrouge, France.
di Clemente
N
N
D000818:Animals; D055430:Bone Morphogenetic Protein 15; D019485:Bone Morphogenetic Proteins / Q000378:metabolism; D051100:Glial Cell Line-Derived Neurotrophic Factor; D055429:Growth Differentiation Factor 9; D006133:Growth Substances / Q000378:metabolism; D006801:Humans; D007265:Inhibins / Q000378:metabolism; D036341:Intercellular Signaling Peptides and Proteins; D008024:Ligands; D009414:Nerve Growth Factors / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000378:metabolism; D017346:Protein Serine-Threonine Kinases / Q000502:physiology*; D017978:Receptors, Growth Factor / Q000502:physiology*; D018125:Receptors, Transforming Growth Factor beta; D015398:Signal Transduction; D016212:Transforming Growth Factor beta / Q000378:metabolism
C525901:BMP15 protein, human; D055430:Bone Morphogenetic Protein 15; D019485:Bone Morphogenetic Proteins; C525897:GDF9 protein, human; C495039:GDNF protein, human; D051100:Glial Cell Line-Derived Neurotrophic Factor; D055429:Growth Differentiation Factor 9; D006133:Growth Substances; D036341:Intercellular Signaling Peptides and Proteins; D008024:Ligands; D009414:Nerve Growth Factors; D009419:Nerve Tissue Proteins; D017978:Receptors, Growth Factor; D018125:Receptors, Transforming Growth Factor beta; D016212:Transforming Growth Factor beta; D007265:Inhibins; D017346:Protein Serine-Threonine Kinases