title: A new approach for the detection of type III hyperlipoproteinemia by RLP-cholesterol assay.
abstract: Type III is a remnant hyperlipoproteinemia identified by the presence of beta-VLDL (remnant lipoprotein) as well as a genetic variant of apo E (apo E2/2). The RLP isolated from the serum of Type III patients by a new method we have developed, the RLPcholesterol assay, was identified as chylomicron and VLDL remnant. In addition, the RLP-C levels of the Type III patients were significantly higher than other hyperlipidemic patients with similar serum TG levels, while the ratio of TC/TG in RLP-C of both groups was not significantly different. The RLP-cholesterol assay appears to be useful for the screening and monitoring of Type III hyperlipoproteinemia when used in conjunction with the assays of serum TG level and genetic apo E isoform analysis.
authors.affiliation: Japan Immunoresearch Laboratories, Takasaki, Gunma, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Nakajima
authors.forename: T
authors.initials: T
authors.lastname: Saito
authors.forename: A
authors.initials: A
authors.lastname: Tamura
authors.forename: M
authors.initials: M
authors.lastname: Suzuki
authors.forename: T
authors.initials: T
authors.lastname: Nakano
authors.forename: M
authors.initials: M
authors.lastname: Adachi
authors.forename: A
authors.initials: A
authors.lastname: Tanaka
authors.forename: N
authors.initials: N
authors.lastname: Tada
authors.forename: H
authors.initials: H
authors.lastname: Nakamura
authors.forename: T
authors.initials: T
authors.lastname: Murase
mesh_terms: D000328:Adult; D000368:Aged; D015243:Cholesterol, VLDL / Q000097:blood*; D002851:Chromatography, High Pressure Liquid; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D006952:Hyperlipoproteinemia Type III / Q000097:blood*; D008297:Male; D008403:Mass Screening / Q000379:methods*; D008875:Middle Aged; D008991:Monitoring, Physiologic / Q000379:methods*; D014280:Triglycerides / Q000097:blood
chemical_list: D015243:Cholesterol, VLDL; D014280:Triglycerides