Propafenone-induced drug fever in the absence of agranulocytosis.
Propafenone is an antiarrhythmic drug used in the treatment of life-threatening ventricular tachyarrhythmias. Adverse reactions necessitating discontinuation of the medication are common. Propafenone-induced drug fever has not been definitively proven. We present a case report of drug fever secondary to propafenone, confirmed with rechallenge.
O'Rourke
D J
DJ
Department of Cardiology, Dartmouth-Hitchcock Medical Center, Lebanon, NH 03756, USA.
Palac
R T
RT
Holzberger
P T
PT
Gerling
B R
BR
Greenberg
M L
ML
D000380:Agranulocytosis / Q000097:blood; D000889:Anti-Arrhythmia Agents / Q000009:adverse effects* / Q000627:therapeutic use; D003937:Diagnosis, Differential; D005334:Fever / Q000097:blood / Q000139:chemically induced* / Q000175:diagnosis; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D011405:Propafenone / Q000009:adverse effects* / Q000627:therapeutic use; D017180:Tachycardia, Ventricular / Q000188:drug therapy*
D000889:Anti-Arrhythmia Agents; D011405:Propafenone