Visual system degeneration induced by blast overpressure.
The effect of blast overpressure on visual system pathology was studied in 14 male Sprague-Dawley rats weighing 360-432 g. Blast overpressure was simulated using a compressed-air driven shock tube, with the aim of studying a range of overpressures causing sublethal injury. Neither control (unexposed) rats nor rats exposed to 83 kiloPascals (kPa) overpressure showed evidence of visual system pathology. Neurological injury to brain visual pathways was observed in male rats surviving blast overpressure exposures of 104-110 kPa and 129-173 kPa. Optic nerve fiber degeneration was ipsilateral to the blast pressure wave. The optic chiasm contained small numbers of degenerated fibers. Optic tract fiber degeneration was present bilaterally, but was predominantly ipsilateral. Optic tract fiber degeneration was followed to nuclear groups at the level of the midbrain, midbrain-diencephalic junction, and the thalamus where degenerated fibers arborized among the neurons of: (i) the superior colliculus, (ii) pretectal region, and (iii) the lateral geniculate body. The superior colliculus contained fiber degeneration localized principally to two superficial layers (i) the stratum opticum (layer III) and (ii) stratum cinereum (layer II). The pretectal area contained degenerated fibers which were widespread in (i) the nucleus of the optic tract, (ii) olivary pretectal nucleus, (iii) anterior pretectal nucleus, and (iv) the posterior pretectal nucleus. Degenerated fibers in the lateral geniculate body were not universally distributed. They appeared to arborize among neurons of the dorsal and ventral nuclei: the ventral lateral geniculate nucleus (parvocellular and magnocellular parts); and the dorsal lateral geniculate nucleus. The axonopathy observed in the central visual pathways and nuclei of the rat brain are consistent with the presence of blast overpressure induced injury to the retina. The orbital cavities of the human skull contain frontally-directed eyeballs for binocular vision. Humans looking directly into an oncoming blast wave place both eyes at risk. With bilateral visual system injury, neurological deficits may include loss or impairments of ocular movements, and of the pupillary and accommodation reflexes, retinal hemorrhages, scotomas, and general blindness. These findings suggest that the retina should be investigated for the presence of traumatic or ischemic cellular injury, hemorrhages, scotomas, and retinal detachment.
Petras
J M
JM
Department of Neurobehavioral Assessment, Walter Reed Army Institute of Research, Washington, D.C. 20307-5100, USA. DR._JM_PETRAS@WRSMTP-CCMAIL.ARMY.MIL
Bauman
R A
RA
Elsayed
N M
NM
D000399:Air Pressure; D000818:Animals; D001369:Axons / Q000473:pathology; D001753:Blast Injuries / Q000473:pathology / Q000503:physiopathology*; D001930:Brain Injuries / Q000453:epidemiology / Q000209:etiology; D005107:Explosions; D005829:Geniculate Bodies / Q000293:injuries / Q000473:pathology; D006470:Hemorrhage; D007031:Hypothalamus / Q000293:injuries / Q000473:pathology; D008297:Male; D009412:Nerve Fibers / Q000378:metabolism / Q000473:pathology*; D009622:Noise / Q000009:adverse effects*; D009897:Optic Chiasm / Q000378:metabolism / Q000473:pathology; D009900:Optic Nerve / Q000473:pathology; D020221:Optic Nerve Injuries; D051381:Rats; D017207:Rats, Sprague-Dawley; D012160:Retina / Q000293:injuries / Q000473:pathology; D013477:Superior Colliculi / Q000293:injuries / Q000473:pathology; D016707:Tissue Fixation; D014793:Visual Cortex / Q000293:injuries* / Q000473:pathology / Q000648:ultrastructure