[Analysis of B cell autoepitopes and mechanisms for autoantibody production in autoimmune diseases].
One of the representative immunological disorders in systemic autoimmune diseases is production of autoantibodies. Recent studies were concentrated on B cell epitopes of intranuclear autoantigens using recombinant proteins. They revealed autoepitopes homologous to those on exogenous agents and multiple epitopes, which respectively indicated molecular mimicry and antigen-driven immune responses as a mechanism for autoantibody production. Further, some autoantigens are thought to be catalyzed in a disease-specific manner. These antigen-specific factors would contribute to the autoantibody production, cooperating with antigen-nonspecific factors such as polyclonal B cell activation, overexpression of cytokines and dysfunction of T cells and antigen presenting cells.
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Inst., Med. Sci. St.-Marianna Univ. School Med.
D000818:Animals; D000974:Antibodies, Antinuclear / Q000276:immunology*; D000917:Antibody Formation; D034961:Antigens, Nuclear; D001327:Autoimmune Diseases / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology*; D000939:Epitopes / Q000276:immunology*; D006801:Humans; D008213:Lymphocyte Activation; D018716:Molecular Mimicry; D009687:Nuclear Proteins / Q000276:immunology
D000974:Antibodies, Antinuclear; D034961:Antigens, Nuclear; D000939:Epitopes; D009687:Nuclear Proteins