Increased levels of lipid oxidation products in low density lipoproteins of patients suffering from rheumatoid arthritis.
9-Hydroxy-10,12-octadecadienoic acid (9-HODE) and 13-hydroxy-9,11-octadecadienoic acid (13-HODE) are accumulated in the low density lipoproteins of patients suffering from rheumatoid arthritis for a factor of 20-50 compared to healthy individuals of the same age. Both acids, derived by lipid peroxidation of linoleic acid, induce the release of interleukin 1 beta. The latter induces bone degression. The genesis of 9- and 13-HODE seems therefore to be an important factor in the development and progression of rheuma; in addition 9-HODE was reported to be a stimulus of inflammation, comparable to leukotrienes.
Jira
W
W
Lehrstuhl für Organische Chemie I, Universität Bayreuth, NW I, Germany.
Spiteller
G
G
Richter
A
A
D000328:Adult; D000368:Aged; D000447:Aldehydes / Q000097:blood; D001172:Arthritis, Rheumatoid / Q000097:blood*; D002849:Chromatography, Gas; D005260:Female; D006801:Humans; D019787:Linoleic Acid; D008041:Linoleic Acids / Q000097:blood; D044243:Linoleic Acids, Conjugated; D015227:Lipid Peroxidation; D008054:Lipid Peroxides / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood* / Q000737:chemistry; D008297:Male; D013058:Mass Spectrometry; D008875:Middle Aged
D000447:Aldehydes; D008041:Linoleic Acids; D044243:Linoleic Acids, Conjugated; D008054:Lipid Peroxides; D008077:Lipoproteins, LDL; C024347:9-hydroxy-10,12-octadecadienoic acid; C098838:2-hydroxyheptanal; C024348:13-hydroxy-9,11-octadecadienoic acid; D019787:Linoleic Acid