title: A clinical evaluation of a bioresorbable barrier with and without decalcified freeze-dried bone allograft in the treatment of molar furcations.
abstract: This study evaluated a bioresorbable barrier with and without decalcified freeze-dried bone allograft (DFDBA) in the treatment of human molar furcations. 14 subjects with paired class II mandibular molar furcation defects participated in the study (8 male and 6 female). The class-II furcation defects were randomly treated with either the resorbable barrier alone or resorbable barrier in combination with decalcified freeze-dried bone allograft (DFDBA). Gingival recession, probing depth, clinical attachment, and bone fill were measured 6 months post-treatment measurements were repeated and each site was surgically re-entered. When the resorbable barrier alone was compared to resorbable barrier in combination with DFDBA, probing depth reduction was significantly (p < 0.01) in favor of the combination therapy. Vertical bone gain was significant with the combination treatment demonstrating more bone fill (p < 0.02). Smoking was also a variable examined in this study. When compared to smokers, non-smokers for both treatment groups revealed greater probing depth reduction, vertical bone gain, and horizontal bone gain. Within the non-smoking group, probing depth reduction was also significantly higher for the resorbable barrier and DFDBA group than the resorbable alone group (p < 0.02). These results illustrate that the probing depth reduction is better in the non-smoker and the best in the non-smoker with the combination therapy of resorbable barrier and DFDBA than with resorbable barrier alone.
authors.affiliation: University of Texas Health Science Center at San Antonio, Department of Periodontics 78284-7894, USA.
authors.forename: P G
authors.initials: PG
authors.lastname: Luepke
authors.forename: J T
authors.initials: JT
authors.lastname: Mellonig
authors.forename: M A
authors.initials: MA
authors.lastname: Brunsvold
mesh_terms: D000328:Adult; D000368:Aged; D016301:Alveolar Bone Loss / Q000473:pathology / Q000601:surgery; D000539:Alveolar Process / Q000473:pathology; D001673:Biodegradation, Environmental; D016025:Bone Transplantation; D005069:Evaluation Studies as Topic; D005260:Female; D017823:Furcation Defects / Q000473:pathology / Q000601:surgery*; D005881:Gingiva / Q000473:pathology; D005889:Gingival Recession / Q000473:pathology / Q000601:surgery; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods; D006801:Humans; D008297:Male; D008567:Membranes, Artificial; D008875:Middle Aged; D008963:Molar / Q000601:surgery; D017622:Periodontal Attachment Loss / Q000473:pathology / Q000601:surgery; D010514:Periodontal Pocket / Q000473:pathology / Q000601:surgery; D010518:Periodontitis / Q000601:surgery; D012907:Smoking / Q000009:adverse effects; D019237:Tooth Cervix / Q000473:pathology; D014184:Transplantation, Homologous
chemical_list: D008567:Membranes, Artificial