Effect of two anti-estrogens, clomiphene citrate and tamoxifen, on cervical mucus and sperm-cervical mucus interaction.
OBJECTIVE
To compare the effect of two ovulation-inducing agents, clomiphene citrate and tamoxifen, on cervical mucus and sperm-cervical mucus interaction.


METHODS
Forty couples with unexplained infertility attending infertility clinic.


METHODS
Cervical mucus scoring and postcoital test done using the Moghissi system in a spontaneous cycle (control cycle) and with clomiphene citrate or tamoxifen (study cycles).


RESULTS
Clomiphene citrate significantly decreased cervical mucus production, whereas tamoxifen significantly improved the total score.


CONCLUSIONS
Tamoxifen is a better drug than clomiphene for ovulation induction in women with poor cervical mucus quality.
Annapurna
V
V
Department of Obstetrics and Gynaecology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Dhaliwal
L K
LK
Gopalan
S
S
D000328:Adult; D002584:Cervix Uteri / Q000187:drug effects* / Q000502:physiology; D002996:Clomiphene / Q000494:pharmacology*; D004965:Estrogen Antagonists / Q000494:pharmacology*; D005260:Female; D005300:Fertility Agents, Female / Q000494:pharmacology*; D006801:Humans; D007246:Infertility / Q000188:drug therapy; D008297:Male; D009093:Mucus / Q000187:drug effects* / Q000502:physiology; D010062:Ovulation Induction; D011446:Prospective Studies; D013094:Spermatozoa / Q000187:drug effects* / Q000502:physiology; D013629:Tamoxifen / Q000494:pharmacology*
D004965:Estrogen Antagonists; D005300:Fertility Agents, Female; D013629:Tamoxifen; D002996:Clomiphene