[Brain metastases of colon and rectum carcinomas].
We analyzed 20 cases with brain metastases from colon or rectum carcinoma. Fourteen were treated with radiotherapy alone (total dose 30-60 Gy), six with neurosurgery plus radiotherapy (total dose 30-40 Gy). All patients had advanced primary tumours (T3 and T4), most of which were poorly differentiated; lymph node metastases were common. In 5 patients (25%) the brain was the first site of distant metastases. Ten patients (50%) had a solitary brain metastasis. As a tendency, the results of surgery plus radiotherapy were superior to those of radiotherapy alone, with respect to palliation of symptoms as well as to local tumour remission and survival. Overall median survival was only 51 days. The 1-year survival rate was 6%. In 5 of 14 cases (36%) symptomatic improvement was observed after radiotherapy alone. Partial remission of the brain metastases occurred in 3 of 14 cases (21%). The presence of extracerebral metastases was the most important prognostic factor. Selected patients considered to have a favourable prognosis may profit from combined treatment, i.e. neurosurgery plus radiotherapy. Despite the short survival time, stereotactic irradiation should be evaluated as an alternative to conventional radiotherapy in the remaining patients because the palliative effect of fractionated external irradiation is relatively disappointing.
Nieder
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Abteilung für Strahlentherapie Radiologische Universitätsklinik, Bundesrepublik Deutschland.
Niewald
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Schnabel
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K
D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000473:pathology / Q000532:radiotherapy / Q000556:secondary* / Q000601:surgery; D003110:Colonic Neoplasms / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D003131:Combined Modality Therapy; D016371:Cranial Irradiation; D003399:Craniotomy; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D018714:Radiotherapy, Adjuvant; D012004:Rectal Neoplasms / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D015996:Survival Rate; D016896:Treatment Outcome