Transforming growth factor alpha-immunoreactivity in neural tissues of the rat stomach.
We report TGF alpha immunoreactivity in neurons of the myenteric plexus and in nerve fibers in the muscle and submucosal layers of the rat stomach. Association of TGF alpha staining nerve fibers to vessels and smooth muscle cells gives morphological evidence that EGF/TGF alpha's actions to increase mucosal blood flow and gastric motility may be mediated by TGF alpha derived from neural structures. These data suggest that TGF alpha plays a role in the neural control of the gastric function.
Hoffmann
P
P
Division of Gastroenterology, Harbor UCLA Medical Center, Torrance, CA 90509, USA.
Zeeh
J M
JM
Lakshmanan
J
J
Liu
L
L
Cooray
D
D
Barajas
L
L
Eysselein
V E
VE
D000818:Animals; D001783:Blood Flow Velocity / Q000502:physiology; D004815:Epidermal Growth Factor / Q000378:metabolism; D005753:Gastric Mucosa / Q000098:blood supply / Q000294:innervation / Q000378:metabolism*; D007150:Immunohistochemistry; D008297:Male; D009197:Myenteric Plexus / Q000378:metabolism; D009412:Nerve Fibers / Q000378:metabolism; D009474:Neurons / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D013270:Stomach / Q000294:innervation*; D016211:Transforming Growth Factor alpha / Q000378:metabolism* / Q000502:physiology
D016211:Transforming Growth Factor alpha; D004815:Epidermal Growth Factor