Inhibitory effect of alginic acids on hyaluronidase and on histamine release from mast cells.
The effects of various types of alginic acid consisting of L-guluronic acids (G) and D-mannuronic acids (M) on hyaluronidase and mast cell degranulation were examined. Alginic acid with an M/G ratio of 1.0 exhibited the strongest inhibition of both activities, the higher molecular weight alginic acids of 150 to 370 kDa being preferable in both cases. Esterification of the carboxyl residue enhanced the latter activity.
Asada
M
M
National Institute of Bioscience and Human-Technology, Ibaraki, Japan.
Sugie
M
M
Inoue
M
M
Nakagomi
K
K
Hongo
S
S
Murata
K
K
Irie
S
S
Takeuchi
T
T
Tomizuka
N
N
Oka
S
S
D000464:Alginates / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D001672:Biocompatible Materials / Q000494:pharmacology*; D002417:Cattle; D015550:Cell Degranulation / Q000187:drug effects; D004789:Enzyme Activation; D004791:Enzyme Inhibitors / Q000494:pharmacology; D004951:Esterification; D020723:Glucuronic Acid; D006490:Hemostatics / Q000737:chemistry / Q000494:pharmacology*; D006603:Hexuronic Acids / Q000494:pharmacology; D006636:Histamine Release / Q000187:drug effects*; D006821:Hyaluronoglucosaminidase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D008297:Male; D008407:Mast Cells / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism / Q000502:physiology; D008970:Molecular Weight; D051381:Rats; D017208:Rats, Wistar; D013737:Testis / Q000166:cytology / Q000187:drug effects / Q000201:enzymology; D014574:Uronic Acids / Q000494:pharmacology
D000464:Alginates; D001672:Biocompatible Materials; D004791:Enzyme Inhibitors; D006490:Hemostatics; D006603:Hexuronic Acids; D014574:Uronic Acids; C007896:guluronic acid; D020723:Glucuronic Acid; C008324:mannuronic acid; D006821:Hyaluronoglucosaminidase