The human interferon-alpha species and hybrid proteins.
Ten years of interferon (IFN) therapy have followed the approval of this agent by the US Food and Drug Administration on June 5, 1986. As the first biotherapeutic approved, IFN-alpha paved the way for the many new biotherapeutics. Regardless of this long history, however, we have just touched the surface of understanding the multitude of human IFNs. This report reviews the history of the purification of human leukocyte IFN and key aspects of our current state of knowledge of human leukocyte IFN genes and proteins.
Pestka
S
S
Department of Molecular Genetics and Microbiology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway 08854-5635, USA.
D000595:Amino Acid Sequence; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D016898:Interferon-alpha / Q000737:chemistry / Q000235:genetics / Q000302:isolation & purification*; D007962:Leukocytes / Q000737:chemistry; D008969:Molecular Sequence Data
D016898:Interferon-alpha