[Changes in bioelectric activity and metabolism of the brain during surgery of the aorta under deep hypothermic arrest of circulation].
Bioelectric activity and metabolism of the brain were studied during surgery on the aorta with deep hypothermal arrest of circulation. The study included 9 patients (7 men and 2 women) aged 13 to 66 years. The mean duration of circulation arrest under deep hypothermia was 48.6 (from 19 to 77) min. Before circulation arrest the patients were cooled to nasopharyngeal temperature of 13.5 +/- 0.5 degrees C and rectal temperature of 15 +/- 0.6 degrees C. Deep hypothermia involved the disappearance of bioelectrical activity and decrease of the spectral power of all EEG frequency bands. The most notable changes in the hemoglobin saturation of the blood in the internal jugular vein bulb (SibO2) were observed during artificial circulation and hypothermal arrest of circulation. Cooling of patients led to a gradual increase of its values. Before deep hypothermal arrest of circulation SjbO2 was as high as 98.4 +/- 0.4%. Over the period of circulation arrest its level dropped to 85.7 +/- 4.8%. Subsequent warming led to its further decrease, and by the end of artificial circulation it was as initially. The content of carbon dioxide in the blood flowing from the brain increased from 17.0 +/- 0.9 to 31.7 +/- 4.7 mm Hg over the period of heart arrest, which may be indicative of the continuing metabolic processes in the brain under conditions of deep hypothermia and justifies the additional drug protection and local hypothermia of the head.
Mierbekov
E M
EM
Flerov
E V
EV
Dement'eva
I I
II
Seleznev
M N
MN
Kukaeva
E A
EA
Sablin
I N
IN
D000293:Adolescent; D000328:Adult; D000368:Aged; D001013:Aorta, Thoracic / Q000601:surgery*; D017545:Aortic Aneurysm, Thoracic / Q000601:surgery; D001921:Brain / Q000378:metabolism / Q000502:physiology*; D004569:Electroencephalography; D005112:Extracorporeal Circulation; D005260:Female; D006324:Heart Arrest, Induced; D006801:Humans; D007036:Hypothermia, Induced; D008297:Male; D008875:Middle Aged