title: Development of the undulation pump total artificial heart.
abstract: The undulation pump is a small size continuous flow displacement type blood pump that has been developed for an artificial heart. Using undulation pumps, 2 types of implantable total artificial hearts (TAHs), the undulation pump TAH (UPTAH) type 1 (UPTAH 1) and UPTAH type 2 (UPTAH 2) were developed. Both UPTAHs were designed to be small enough to implant into the chest of a goat, the experimental animal. UPTAH 1 could be reduced in size to 75 mm in diameter and 78 mm in length. The weight was 520 g. UPTAH 2 could be reduced in size to 75 mm in diameter and 80 mm in length. The weight was 650 g. UPTAH 2 could be tested in an animal experiment using an adult female goat weighing 52.3 kg. The UPTAH 2 could be implanted successfully into the goat's chest with a good fit. The goat stood after the surgery and extubation and survived for 3 h and 40 min; thus, the potential of the UPTAH for a practical implantable TAH was demonstrated.
authors.affiliation: Institute of Medical Electronics, Faculty of Medicine, University of Tokyo, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Abe
authors.forename: T
authors.initials: T
authors.lastname: Chinzei
authors.forename: T
authors.initials: T
authors.lastname: Isoyama
authors.forename: T
authors.initials: T
authors.lastname: Ono
authors.forename: S
authors.initials: S
authors.lastname: Mochizuki
authors.forename: K
authors.initials: K
authors.lastname: Mabuchi
authors.forename: K
authors.initials: K
authors.lastname: Baba
authors.forename: H
authors.initials: H
authors.lastname: Matsuura
authors.forename: Y P
authors.initials: YP
authors.lastname: Sun
authors.forename: A
authors.initials: A
authors.lastname: Kouno
authors.forename: K
authors.initials: K
authors.lastname: Atsumi
authors.forename: I
authors.initials: I
authors.lastname: Fujimasa
authors.forename: K
authors.initials: K
authors.lastname: Imachi
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena; D001783:Blood Flow Velocity / Q000502:physiology; D001794:Blood Pressure / Q000502:physiology; D002302:Cardiac Output / Q000502:physiology; D004389:Durable Medical Equipment; D004869:Equipment Safety; D005260:Female; D006041:Goats; D006354:Heart, Artificial / Q000639:trends*; D008904:Miniaturization; D011140:Polyurethanes / Q000592:standards; D011652:Pulmonary Circulation / Q000502:physiology; D011669:Pulmonary Wedge Pressure / Q000502:physiology; D011786:Quality Control; D013927:Thrombosis / Q000517:prevention & control
chemical_list: D011140:Polyurethanes