title: Colosplenic fistula in a patient treated with interleukin-2 for malignant melanoma.
abstract: Interleukin-2 (IL-2) therapy often causes gastrointestinal side effects and at least 8 cases of bowel perforation have been reported. The patient reported here developed a colosplenic fistula, diagnosed by CT, with no neoplastic involvement of these organs. Awareness of these complications of IL-2 can help lead to earlier diagnosis.
authors.affiliation: Department of Radiology, Loyola University Medical Center, Maywood, IL 60153, USA.
authors.forename: E S
authors.initials: ES
authors.lastname: Chun
authors.forename: T C
authors.initials: TC
authors.lastname: Demos
authors.forename: E R
authors.initials: ER
authors.lastname: Gaynor
mesh_terms: D000328:Adult; D003106:Colon / Q000000981:diagnostic imaging; D003108:Colonic Diseases / Q000139:chemically induced* / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D007376:Interleukin-2 / Q000009:adverse effects*; D007412:Intestinal Fistula / Q000139:chemically induced* / Q000000981:diagnostic imaging; D008207:Lymphatic Metastasis; D008545:Melanoma / Q000150:complications* / Q000628:therapy; D012878:Skin Neoplasms / Q000150:complications* / Q000628:therapy; D013154:Spleen / Q000000981:diagnostic imaging; D013158:Splenic Diseases / Q000139:chemically induced* / Q000000981:diagnostic imaging; D014057:Tomography, X-Ray Computed
chemical_list: D007376:Interleukin-2