title: A case-control study of self-reported exposures to pesticides and pancreas cancer in southeastern Michigan.
abstract: A case-control study of pancreas cancer in residents, aged 30-79 years, of 18 counties in southeastern Michigan was conducted to investigate the risks of exposure to DDT and related materials in the general population. Sixty-six people with cytologically diagnosed pancreas cancer were identified using 7 participating hospitals in metropolitan Detroit and Ann Arbor. One hundred and thirty-one controls were frequency-matched to the cases on age, sex, ethicity and county of residence by random-digit dialing. All study participants were administered a questionnaire to assess life-time exposure to pesticides from both environmental and occupational sources, family history of cancer, past medical history, smoking history and demographic information. A statistically significant increased risk was found for self-reported exposure to ethylan (1,1-dichloro-2,2-bis(4-methoxyphenyl) ethane). Increased odds ratios were observed for self-reported exposures to chloropropylate and DDT, as well as for the summary group of organochlorine pesticides which included all of these materials, though these associations were not significant.
authors.affiliation: Department of Preventive and Societal Medicine, University of Nebraska Medical Center, Omaha 68198-4350, USA. jfryzek@mail.unmc.edu
authors.forename: J P
authors.initials: JP
authors.lastname: Fryzek
authors.forename: D H
authors.initials: DH
authors.lastname: Garabrant
authors.forename: S D
authors.initials: SD
authors.lastname: Harlow
authors.forename: R K
authors.initials: RK
authors.lastname: Severson
authors.forename: B W
authors.initials: BW
authors.lastname: Gillespie
authors.forename: M
authors.initials: M
authors.lastname: Schenk
authors.forename: D
authors.initials: D
authors.lastname: Schottenfeld
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D003634:DDT / Q000009:adverse effects; D004781:Environmental Exposure; D005260:Female; D006801:Humans; D007306:Insecticides / Q000009:adverse effects*; D008297:Male; D008824:Michigan / Q000453:epidemiology; D008875:Middle Aged; D016273:Occupational Exposure; D016017:Odds Ratio; D010190:Pancreatic Neoplasms / Q000139:chemically induced / Q000453:epidemiology*; D010575:Pesticides / Q000009:adverse effects*; D012306:Risk; D012907:Smoking; D011795:Surveys and Questionnaires
chemical_list: D007306:Insecticides; D010575:Pesticides; D003634:DDT