title: THEMPO: a knowledge-based system for therapy planning in pediatric oncology.
abstract: This article describes the knowledge-based system THEMPO (Therapy Management in Pediatric Oncology), which supports protocol-directed therapy planning and configuration in pediatric oncology. THEMPO provides a semantic network controlled by graph grammars to cover the different types of knowledge relevant in the domain, and offers a suite of acquisition tools for knowledge base authoring. Medical problem solvers, operating on the oncological network, reason about adequate therapeutic and diagnostic timetables for a patient. Furthermore, a corresponding patient record, also based on semantic networks and graph grammars, has been implemented to represent the course of therapy of an oncological patient.
authors.affiliation: Institut für Informatik, Universität Leizpig, Germany.
authors.forename: R
authors.initials: R
authors.lastname: Müller
authors.forename: M
authors.initials: M
authors.lastname: Sergl
authors.forename: U
authors.initials: U
authors.lastname: Nauerth
authors.forename: D
authors.initials: D
authors.lastname: Schoppe
authors.forename: K
authors.initials: K
authors.lastname: Pommerening
authors.forename: H M
authors.initials: HM
authors.lastname: Dittrich
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use; D001185:Artificial Intelligence; D002648:Child; D003131:Combined Modality Therapy; D003196:Computer Graphics; D005103:Expert Systems; D006801:Humans; D016347:Medical Records Systems, Computerized / Q000295:instrumentation; D009369:Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy; D009447:Neuroblastoma / Q000188:drug therapy / Q000532:radiotherapy; D010347:Patient Care Planning; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy / Q000532:radiotherapy; D018714:Radiotherapy, Adjuvant; D012984:Software; D013813:Therapy, Computer-Assisted / Q000295:instrumentation*; D016896:Treatment Outcome