[The anti-edematous effect of the preparation polyosm in acute hypertensive encephalopathy].
Experiments were conducted on Wistar rats to study the effect of intravenous infusion of polyosm (solution of polyethyleneoxide 400) on the parameters of brain tissue edema-swelling (according to impedancemetry findings) and the local cerebral blood flow on a model of acute hypertensive encephalopathy. Under such conditions the drug hastened involution of edema-swelling of the brain tissue and prevented a decrease in cerebral blood flow.
Plotnikov
M B
MB
Smol'iakova
V I
VI
Chernysheva
G A
GA
D000208:Acute Disease; D000818:Animals; D001929:Brain Edema / Q000139:chemically induced / Q000188:drug therapy*; D004195:Disease Models, Animal; D004234:Diuretics, Osmotic / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D006973:Hypertension / Q000139:chemically induced / Q000188:drug therapy*; D008297:Male; D009638:Norepinephrine; D010208:Papaverine / Q000031:analogs & derivatives; D011092:Polyethylene Glycols / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D018709:Statistics, Nonparametric
D004234:Diuretics, Osmotic; D011092:Polyethylene Glycols; C005317:drotaverin; D010208:Papaverine; D009638:Norepinephrine