title: Future directions in the development of new antitubercular drugs. Where do we go from here?
abstract: The global resurgence of tuberculosis and rampant drug resistance have rekindled the need for and interest in the development of new antitubercular drugs. Delineation of the possible drug targets furnished by the various mycobacterial cell components might result in rational approaches to the development of such agents. In the future, molecular genetics might help both in the bioengineering and rapid screening of the activity of new compound. Collaboration is anticipated between the pharmaceutical industry and academic institutions in these areas.
authors.affiliation: Tuberculosis and Chest Unit, Grantham Hospital, Hong Kong.
authors.forename: W W
authors.initials: WW
authors.lastname: Yew
authors.forename: C H
authors.initials: CH
authors.lastname: Chau
mesh_terms: D000995:Antitubercular Agents / Q000494:pharmacology / Q000592:standards* / Q000627:therapeutic use; D002473:Cell Wall / Q000187:drug effects / Q000502:physiology; D015195:Drug Design; D004345:Drug Industry / Q000639:trends*; D018432:Drug Resistance, Multiple; D005818:Genetic Engineering; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D009696:Nucleic Acids / Q000378:metabolism; D010641:Phenotype; D014176:Protein Biosynthesis; D014376:Tuberculosis / Q000188:drug therapy*
chemical_list: D000995:Antitubercular Agents; D009696:Nucleic Acids