[A case of malignant lymphoma after renal transplantation].
A case of a primary brain malignant lymphoma after renal transplantation and immunosuppressive therapy is reported. A 41-year-old male patient had been treated with 125 mg/day of azathioprine and 10 mg/day of prednisolone after renal transplantation. He had also been suffering from various infectious diseases. Multiple brain tumors were found and diagnosed as having B-cell, diffuse large cell type malignant lymphoma. In spite of moderate response to irradiation, he died of pneumonia. The anti-Epstein Barr virus antibodies changed from a negative to a positive level after renal transplantation and they increased markedly after brain malignant lymphoma had been found. The number of T- and B-lymphocytes also decreased markedly at that time. So the Epstein-Barr virus was suspected to be the cause of the malignant lymphoma.
Oyama
H
H
Department of Neurosurgery, Chukyo Hospital.
Yamao
K
K
Sugiyama
T
T
Matsuura
O
O
Murakami
S
S
Ikeda
K
K
Inoue
S
S
D000328:Adult; D001379:Azathioprine / Q000009:adverse effects*; D001932:Brain Neoplasms / Q000209:etiology*; D006566:Herpesviridae Infections / Q000150:complications; D004854:Herpesvirus 4, Human; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D016030:Kidney Transplantation; D016393:Lymphoma, B-Cell / Q000209:etiology*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000209:etiology*; D008297:Male; D011183:Postoperative Complications; D011239:Prednisolone / Q000009:adverse effects*
D007166:Immunosuppressive Agents; D011239:Prednisolone; D001379:Azathioprine