title: Muscarinic control of phase III contractions and motilin release in dogs.
abstract: The role of muscarinic receptor subtype(s) in the control of gastric phase III contractions and motilin release was determined in dogs. Pirenzepine (226 nmol/kg/h) shortened the phase III cycle, causing an early increase in plasma motilin concentrations. Both AF-DX116BS and 4-DAMP inhibited the occurrence of spontaneous and motilin-induced phase III contractions, and 4-DAMP also inhibited the spontaneous increase in plasma motilin concentration. Only 4-DAMP inhibited carbachol-induced motilin release in perifused duodenal mucosal cells. In conclusion, M1 receptors are involved in the indirect inhibition of motilin release. Motilin-induced contractions are mediated mainly by M3 receptors and partly by M2 receptors, and M3 receptors are present in motilin-producing cells.
authors.affiliation: Gastrointestinal Research Laboratory, Gunma University, Maebashi, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Yamada
authors.forename: A
authors.initials: A
authors.lastname: Mizumoto
authors.forename: M
authors.initials: M
authors.lastname: Satoh
authors.forename: N
authors.initials: N
authors.lastname: Haga
authors.forename: Z
authors.initials: Z
authors.lastname: Itoh
mesh_terms: D000818:Animals; D002469:Cell Separation; D004285:Dogs; D004386:Duodenum; D005260:Female; D007262:Infusions, Intravenous; D007413:Intestinal Mucosa / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D008297:Male; D009037:Motilin / Q000097:blood / Q000187:drug effects / Q000378:metabolism*; D018727:Muscarinic Antagonists / Q000008:administration & dosage*; D010880:Piperidines / Q000494:pharmacology; D010890:Pirenzepine / Q000031:analogs & derivatives / Q000494:pharmacology; D013270:Stomach / Q000187:drug effects* / Q000502:physiology
chemical_list: D018727:Muscarinic Antagonists; D010880:Piperidines; D010890:Pirenzepine; D009037:Motilin; C042375:4-diphenylacetoxy-1,1-dimethylpiperidinium; C048593:otenzepad