Increased salt retention and hypertension from non-steroidal agents in the elderly.
We studied blood pressure and natriuretic responses to acute salt loading, and the effect of non-steroidal anti-inflammatory agents on these responses, in five healthy normotensive women aged 65 to 71 years. Five women aged 25 to 31 years acted as controls. Intravenous saline loading, with and without prior ingestion of ibuprofen, was 15 ml/kg/h for 3 h. Baseline blood pressures were higher in the elderly. Saline infusion without ibuprofen raised systolic blood pressure (SBP) by about 25 mmHg in the older group only. Ibuprofen increased baseline SBP in the elderly (129 +/- 6 vs. 116 +/- 5 mmHg, p < 0.05). Saline loading after ibuprofen again raised blood pressure by about 25 mmHg in the elderly only. The elderly group showed markedly increased sodium excretion during saline loading, but this was reduced by ibuprofen. Ibuprofen had no effect on SBP or sodium excretion in controls. Ageing appears to increase susceptibility to salt retention and hypertension from non-steroidal anti-inflammatory agents.
Mulkerrin
E C
EC
Charles A. Dana Research Institute, Renal Division, Beth Israel Hospital, Boston, MA 02215, USA.
Clark
B A
BA
Epstein
F H
FH
D000328:Adult; D000368:Aged; D000375:Aging / Q000378:metabolism*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000139:chemically induced* / Q000378:metabolism; D007052:Ibuprofen / Q000009:adverse effects*; D007275:Injections, Intravenous; D012964:Sodium / Q000652:urine; D012965:Sodium Chloride / Q000378:metabolism* / Q000493:pharmacokinetics
D000894:Anti-Inflammatory Agents, Non-Steroidal; D012965:Sodium Chloride; D012964:Sodium; D007052:Ibuprofen