Identification of monocyte chemoattractant protein-1 in senile plaques and reactive microglia of Alzheimer's disease.
It has been shown that human monocytes express monocyte chemoattractant protein-1 (MCP-1), an inflammatory factor, in response to non-fibrillar beta-amyloid protein. Reactive microglia and inflammatory factors were reported to be present in beta-amyloid deposits (senile plaques) in Alzheimer's disease, suggesting the presence of MCP-1 in senile plaques. To address this issue, we examined MCP-1 immunoreactivity in senile plaques using a mouse monoclonal anti-MCP-1 antibody. Monocyte chemoattractant protein-1 was found immunohistochemically in mature senile plaques and reactive microglia but not in immature senile plaques of brain tissues from five patients with Alzheimer's disease. These findings suggest that MCP-1-related inflammatory events induced by reactive microglia contribute to the maturation of senile plaques.
Ishizuka
K
K
Department of Neuropsychiatry, Kumamoto University School of Medicine, Japan.
Kimura
T
T
Igata-yi
R
R
Katsuragi
S
S
Takamatsu
J
J
Miyakawa
T
T
D000368:Aged; D000544:Alzheimer Disease / Q000276:immunology* / Q000503:physiopathology; D001923:Brain Chemistry; D018932:Chemokine CCL2 / Q000302:isolation & purification*; D006801:Humans; D007150:Immunohistochemistry; D007249:Inflammation; D017628:Microglia / Q000276:immunology*; D008875:Middle Aged; D016874:Neurofibrillary Tangles / Q000276:immunology*
D018932:Chemokine CCL2