Protective effect of acetaminophen against acute gastric mucosal lesions induced by ischemia-reperfusion in the rat.
We examined the effect of acetaminophen, an analgesic and antipyretic drug, on acute gastric mucosal injury induced by ischemia-reperfusion in rats. Ischemia-reperfusion was induced by clamping the celiac artery for 30 min with a small clip. Sixty minutes after reperfusion, the total area of erosions was measured. Acetaminophen (300 and 500 mg/kg) administered intraperitoneally 90 min before the ischemia significantly reduced the total area of erosions. The drug also inhibited the increase in lipid peroxide levels induced by ischemia-reperfusion in the gastric tissue and the increase in lipid peroxidation caused by the hydroxyl radical, OH., in vitro. Gastric prostaglandin E2 (PGE2) contents tended to increase after ischemia-reperfusion in both control and acetaminophen-treated groups. A significant difference in gastric PGE2 contents between control and acetaminophen-treated groups was not observed. The results indicate that acetaminophen may protect the gastric mucosa against ischemia-reperfusion injury, probably by blocking hydroxyl-radical-induced membrane damage.
Nakamoto
K
K
Department of Clinical Pharmacology, Faculty of Medicine, Tottori University, Yonago, Japan.
Kamisaki
Y
Y
Wada
K
K
Kawasaki
H
H
Itoh
T
T
D000082:Acetaminophen / Q000008:administration & dosage*; D000208:Acute Disease; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage*; D015232:Dinoprostone / Q000032:analysis; D005609:Free Radicals; D005753:Gastric Mucosa / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008054:Lipid Peroxides / Q000032:analysis; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000473:pathology / Q000517:prevention & control*
D000975:Antioxidants; D005609:Free Radicals; D008054:Lipid Peroxides; D000082:Acetaminophen; D015232:Dinoprostone