title: Urodynamic correlates of resolution of reflux in meningomyelocele patients.
abstract: OBJECTIVE
  Resolution of reflux in meningomyelocele patients is a reflection of improved bladder storage. We correlated resolution of reflux with changes observed in sequential urodynamic studies.
  
  
  METHODS
  The study included 27 children with meningomyelocele born between 1975 and 1985 who presented with or developed vesicoureteral reflux. Resolution of reflux was observed during the 10-year followup period as they were treated with a regimen of clean intermittent catheterization and pharmaco-therapy. Urodynamic studies were performed when vesicoureteral reflux was present and subsequent to its resolution. The urodynamic parameters compared in the 2 studies included bladder capacity, pressure specific bladder volume, bladder compliance and leak point pressure.
  
  
  RESULTS
  Significant increases in bladder capacity, pressure specific bladder volume and bladder compliance were noted. Leak point pressure appeared to be decreased subsequent to resolution of reflux.
  
  
  CONCLUSIONS
  Resolution of reflux in meningomyelocele patients correlates with changes in parameters of bladder storage observed on sequential urodynamic studies.
authors.affiliation: Department of Surgery, Hospital for Sick Children, Toronto, Canada.
authors.forename: S K
authors.initials: SK
authors.lastname: Agarwal
authors.forename: G A
authors.initials: GA
authors.lastname: McLorie
authors.forename: D
authors.initials: D
authors.lastname: Grewal
authors.forename: B D
authors.initials: BD
authors.lastname: Joyner
authors.forename: D J
authors.initials: DJ
authors.lastname: Bägli
authors.forename: A E
authors.initials: AE
authors.lastname: Khoury
mesh_terms: D002648:Child; D006801:Humans; D008591:Meningomyelocele / Q000150:complications* / Q000503:physiopathology; D012074:Remission Induction; D012189:Retrospective Studies; D001743:Urinary Bladder / Q000503:physiopathology; D014563:Urodynamics; D014718:Vesico-Ureteral Reflux / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*