Summing up, weak immunomodulating signals of Tahyna virus and immunomodulating drugs induce immunosuppression in mice.
The successive injection of non-immunomodulating doses of Tahyna virus (100 LD50) and non-immunomodulating doses of immunomodulating drugs, such as purified staphylococcal toxoid or glucosaminylmuramyldipeptide (Likopid), to mice were accompanied by a decrease in the IgM plaque-forming cell response to sheep red blood cells.
Semenova
I B
IB
Gamaleya Research Institute of Epidemiology and Microbiology, Moscow, Russia.
Kalenderov
A K
AK
Vargin
V V
VV
Semenov
B F
BF
D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000031:analogs & derivatives / Q000494:pharmacology; D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D004306:Dose-Response Relationship, Immunologic; D002141:Encephalitis Virus, California / Q000276:immunology*; D007165:Immunosuppression Therapy; D051379:Mice; D008808:Mice, Inbred CBA; D013208:Staphylococcal Toxoid / Q000494:pharmacology
D000276:Adjuvants, Immunologic; D013208:Staphylococcal Toxoid; D000119:Acetylmuramyl-Alanyl-Isoglutamine; C063429:glucosaminylmuramyl-2-alanine-D-isoglutamine