title: In vivo 'purging' of residual disease in CLL with Campath-1H.
abstract: We assessed the role of human CD52 antibody (Campath-1H) in six patients with chronic lymphocytic leukaemia (CLL) treated to maximal response with purine analogues (fludarabine/deoxycoformycin) in whom persistent leukaemic infiltration of blood and bone marrow had precluded autologous stem cell transplantation. Five patients achieved haematological and histological complete remission following Campath-1H and one had minimal focal residual CLL in a trephine biopsy. Autologous transplantation was performed in two patients without complications and with rapid haemopoietic engraftment. Treatment with Campath-1H may be of value in eradicating residual disease in CLL and may facilitate high-dose therapy in young patients.
authors.affiliation: Academic Department of Haematology and Cytogenetics, Institute of Cancer Research, Royal Marsden Hospital, London.
authors.forename: M J
authors.initials: MJ
authors.lastname: Dyer
authors.forename: S M
authors.initials: SM
authors.lastname: Kelsey
authors.forename: H J
authors.initials: HJ
authors.lastname: Mackay
authors.forename: E
authors.initials: E
authors.lastname: Emmett
authors.forename: P
authors.initials: P
authors.lastname: Thornton
authors.forename: G
authors.initials: G
authors.lastname: Hale
authors.forename: H
authors.initials: H
authors.lastname: Waldmann
authors.forename: A C
authors.initials: AC
authors.lastname: Newland
authors.forename: D
authors.initials: D
authors.lastname: Catovsky
mesh_terms: D000328:Adult; D000074323:Alemtuzumab; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D061067:Antibodies, Monoclonal, Humanized; D000912:Antibodies, Neoplasm / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D018365:Neoplasm, Residual / Q000628:therapy*; D015649:Pentostatin / Q000627:therapeutic use; D014740:Vidarabine / Q000031:analogs & derivatives / Q000627:therapeutic use
chemical_list: D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D000912:Antibodies, Neoplasm; D015649:Pentostatin; D000074323:Alemtuzumab; D014740:Vidarabine; C024352:fludarabine