title: The role of oxygen free radicals in idiopathic facial pain.
abstract: Patients with chronic facial pain including those with facial arthromyalgia (TMJ dysfunction syndrome) were investigated for evidence of abnormal systemic and intra-articular free radical activity. Chronic facial pain patients showed significantly raised serum 2,3-dihydroxybenzoic acid after an oral dose of 1.2 g of aspirin which indicates increased systemic free radical activity. This was reflected in the TMJ aspirates of the facial arthromyalgia patients which contained thiobarbituric acid-reactive substance (TBA-RS) which is also a product of free radical activity. The synovial aspirates also contained high levels of the hyperalgesic eicosanoid 15-HETE. However, there was no difference between the painful and symptom-free joints, which suggested that in part the clinical features are probably determined by asymmetrical masticatory function or as yet unknown algesic factors such as local cytokine production.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Eastman Dental and University College London Hospitals, UK.
authors.forename: B
authors.initials: B
authors.lastname: Aghabeigi
authors.forename: M
authors.initials: M
authors.lastname: Haque
authors.forename: M
authors.initials: M
authors.lastname: Wasil
authors.forename: S J
authors.initials: SJ
authors.lastname: Hodges
authors.forename: B
authors.initials: B
authors.lastname: Henderson
authors.forename: M
authors.initials: M
authors.lastname: Harris
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000493:pharmacokinetics; D001241:Aspirin / Q000008:administration & dosage / Q000493:pharmacokinetics; D016022:Case-Control Studies; D002908:Chronic Disease; D016207:Cytokines / Q000378:metabolism; D015232:Dinoprostone / Q000032:analysis; D005157:Facial Pain / Q000209:etiology* / Q000378:metabolism; D005260:Female; D005609:Free Radicals / Q000378:metabolism / Q000494:pharmacology; D005841:Gentisates; D006801:Humans; D062385:Hydroxybenzoates / Q000097:blood; D006893:Hydroxyeicosatetraenoic Acids / Q000032:analysis; D007502:Iron Chelating Agents / Q000032:analysis; D007975:Leukotriene B4 / Q000032:analysis; D008297:Male; D008409:Mastication; D008875:Middle Aged; D017382:Reactive Oxygen Species / Q000378:metabolism / Q000502:physiology*; D013582:Synovial Fluid / Q000737:chemistry; D013704:Temporomandibular Joint / Q000378:metabolism; D013706:Temporomandibular Joint Dysfunction Syndrome / Q000209:etiology / Q000378:metabolism; D017392:Thiobarbituric Acid Reactive Substances / Q000032:analysis
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D016207:Cytokines; D005609:Free Radicals; D005841:Gentisates; D062385:Hydroxybenzoates; D006893:Hydroxyeicosatetraenoic Acids; D007502:Iron Chelating Agents; D017382:Reactive Oxygen Species; D017392:Thiobarbituric Acid Reactive Substances; D007975:Leukotriene B4; C009135:2,3-dihydroxybenzoic acid; C025984:15-hydroxy-5,8,11,13-eicosatetraenoic acid; D015232:Dinoprostone; D001241:Aspirin; C010925:2,5-dihydroxybenzoic acid