title: Age-related changes of urinary nitrite/nitrate excretion in normal children.
abstract: We measured the urinary excretion of nitrite/nitrate, stable metabolites of nitric oxide, using the brucine method in 90 healthy normal children (47 boys and 43 girls), aged from 1.0 to 17.1 years, to establish the age-related normal range in children. The urinary nitrite/nitrate excretion was highest in the youngest children and decreased in an age-dependent manner to reach constant levels at about 12 years of age in both sexes. The data may be useful in identifying sick children with abnormal nitric oxide production.
authors.affiliation: Department of Pediatrics, Fukui Medical School, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Tsukahara
authors.forename: M
authors.initials: M
authors.lastname: Hiraoka
authors.forename: C
authors.initials: C
authors.lastname: Hori
authors.forename: T
authors.initials: T
authors.lastname: Miyanomae
authors.forename: K
authors.initials: K
authors.lastname: Kikuchi
authors.forename: M
authors.initials: M
authors.lastname: Sudo
mesh_terms: D000293:Adolescent; D000375:Aging / Q000652:urine*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D009566:Nitrates / Q000652:urine*; D009569:Nitric Oxide / Q000378:metabolism; D009573:Nitrites / Q000652:urine*; D012016:Reference Values
chemical_list: D009566:Nitrates; D009573:Nitrites; D009569:Nitric Oxide