Electrophysiologic target localization in posteroventral pallidotomy.
The current interest in stereotactic posteroventral pallidotomy (PVP) for treating Parkinson's disease and the variability of published results have raised questions regarding techniques for target localization. In our technique the probe is guided to the optimum target at the most ventral pallidum and ansa lenticularis by macroelectrode stimulation of the internal capsule and optic tract from within the globus pallidus, with the thresholds providing a relative measure of the electrode proximity to these structures. We have characterized these localizing macroelectrode stimulation parameters in 57 posteroventral pallidotomies with consistent anatomic lesion placement, excellent outcome, and no complications. Using a 1.8 x 2.0 mm radiofrequency electrode for macroelectrode stimulation (RFG-3C, Radionics Inc.), minimum voltages (thresholds) to activate motor (at a frequency of 2 Hz) or visual (at a frequency of 100 Hz) responses as well as impedance measurements were obtained at the final target (Tf) and at distances proximal to Tf along the electrode trajectory. The visual and motor threshold voltages at Tf via our standard approach angles (50 degrees above base plane, 20 degrees from the sagittal plane), had a range of 1.0 to 1.5 V, and 2.0 to 3.5 V respectively. We also found that as the probe approaches Tf there is a significant decrease in voltage thresholds for motor (P < .0001) and visual (P < .0001) responses in an individual patient indicating that the probe is converging on these structures. Increases in impedance between Tf, 2-3 mm, and 4-5 mm proximal to Tf were also statistically significant (P < .0001). Microelectrode recording to electrophysiological neuronal activity at various points along the trajectory towards the target showed distinct firing patterns providing identification of the globus pallidus externus and internus, ansa lenticularis, and optic tract. Macroelectrode electrophysiological stimulation within the target volume, inducing threshold responses in the internal capsule and optic tract, provides for accurate localization of the most effective PVP target in the ansa lenticularis. In unresponsive patients, the utilization of microelectrode recording for the identification of the pallidal borders and the optic tract improves safety.
Iacono
R P
RP
Loma Linda University Medical Center, CA, USA.
Carlson
J D
JD
Kuniyoshi
S M
SM
Li
Y J
YJ
Mohamed
A S
AS
Maeda
G
G
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001931:Brain Mapping / Q000295:instrumentation*; D004292:Dominance, Cerebral / Q000502:physiology; D004566:Electrodes; D004569:Electroencephalography / Q000295:instrumentation; D005260:Female; D005917:Globus Pallidus / Q000503:physiopathology / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009474:Neurons / Q000502:physiology; D010300:Parkinson Disease / Q000503:physiopathology / Q000601:surgery*; D013238:Stereotaxic Techniques / Q000295:instrumentation*