title: Polyamines in the male reproductive system.
abstract: This review covers some common aspects of the biosynthesis, interconversion pathways and biochemical functions of polyamines. A particular emphasis is given in experimental models as well as humans, to their presence in the male gonad, prostate gland, seminal vesicles, epididymis and semen. The interaction between hormones (androgens, LH, FSH and PRL) and the main enzymes involved on the polyamine biosynthesis, and the relationship of these compounds on cell growth and differentiation, are also discussed. In this regard, an attention is offered to the potential role of polyamines during early spermatogenesis stages and the use of some enzymes involved in their biosynthesis as sensitive and specific markers of the action of androgens and antiandrogens in the epididymis. Finally, a special issue is addressed to the controversial information documented on polyamines, their oxidation products and the relationship with male fertility.
authors.affiliation: Laboratorio de Esteroides, Instituto de Biología y Medicina Experimental, Buenos Aires, Argentina.
authors.forename: R S
authors.initials: RS
authors.lastname: Calandra
authors.forename: S B
authors.initials: SB
authors.lastname: Rulli
authors.forename: M B
authors.initials: MB
authors.lastname: Frungieri
authors.forename: M O
authors.initials: MO
authors.lastname: Suescun
authors.forename: S I
authors.initials: SI
authors.lastname: González-Calvar
mesh_terms: D000123:Acetyltransferases / Q000378:metabolism; D000818:Animals; D015317:Biogenic Polyamines / Q000378:metabolism / Q000502:physiology*; D006224:Cricetinae; D004822:Epididymis / Q000378:metabolism*; D006801:Humans; D008297:Male; D008322:Mammals; D008647:Mesocricetus; D051379:Mice; D009952:Ornithine / Q000378:metabolism; D011467:Prostate / Q000378:metabolism*; D011700:Putrescine / Q000096:biosynthesis; D051381:Rats; D012661:Semen / Q000378:metabolism*; D012669:Seminal Vesicles / Q000378:metabolism*; D013095:Spermidine / Q000096:biosynthesis; D013096:Spermine / Q000096:biosynthesis; D013737:Testis / Q000378:metabolism*
chemical_list: D015317:Biogenic Polyamines; D013096:Spermine; D009952:Ornithine; D000123:Acetyltransferases; D013095:Spermidine; D011700:Putrescine