Pigmented choroid plexus carcinoma: a cytogenetic and ultrastructural study.
A pigmented choroid plexus carcinoma was studied. The pigment was Fontana-positive, and the neoplastic cells focally expressed melanosomal marker HMB45 and contained probable aberrant melanosomes. The tumor was composed of two pseudodiploid clones, having the karyotypes 46,XY,inv(4)(q12q35),t(6;15)(q21;q22),inv(7)(p11.2q22),t(19; 22) (q13.4;q11.2)[15]/46,XY,t(4;14)(q31.1; p11.2),t(12;13)(p11.1;q34)[6]. The available data seem to indicate that rearrangements of 7p11-12, 9q11-12, 15q22, and 19q13.4 may play a role in the development of choroid plexus carcinomas.
Dobin
S M
SM
Department of Pathology Scott & White Clinic, Temple, Texas, USA.
Donner
L R
LR
D002277:Carcinoma / Q000235:genetics* / Q000648:ultrastructure; D002648:Child; D016545:Choroid Plexus Neoplasms / Q000235:genetics* / Q000648:ultrastructure; D006801:Humans; D007621:Karyotyping; D008297:Male; D008854:Microscopy, Electron