[Diagnostic algorithm for the evaluation of estrogen receptor function in breast carcinoma].
Hormone receptor expression in breast cancer is not always a reliable reflection of their functional ability. This limitation affords a less valid prediction of tumor cell response to hormone treatment. For explanation of this phenomenon, the relationship between estrogen and progesterone receptor expression versus proliferative activity and the estrogen receptor related protein p29 expression was examined. Additional aim was to provide clues for interpretation of immunohistochemical findings from the point of view of the functional status of the estrogen receptor regulatory cascade. The results made possible establishment of a new diagnostic algorithm for evaluation of the estrogen receptor functional ability in breast cancer.
Kolár
Z
Z
Ustav patologie, Lékarská fakulta Univerzity Palackého, Olomouc.
D001943:Breast Neoplasms / Q000378:metabolism*; D005260:Female; D006801:Humans; D018809:Proliferating Cell Nuclear Antigen / Q000032:analysis; D011960:Receptors, Estrogen / Q000378:metabolism*; D011980:Receptors, Progesterone / Q000378:metabolism
D018809:Proliferating Cell Nuclear Antigen; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone