title: DNA variation at the Sod locus of Drosophila melanogaster: an unfolding story of natural selection.
abstract: Patterns of variation at the Sod locus of Drosophila melanogaster suggest that the protein polymorphism at this locus has very recently arisen. In addition, it appears that a previously rare DNA variant has been recently and rapidly driven to intermediate frequency. From the size of the region (>20 kb) that has been swept along with this rare variant, and patterns of linkage disequilibrium in the region, it is inferred that strength of selection was large (s > 0.01) and that the sweep occurred more than 25,000 generations ago. In addition, there are striking similarities to patterns of variation observed at the Est6 and Est-P loci, which are located approximately 1,000 kb from Sod.
authors.affiliation: Department of Ecology and Evolutionary Biology, University of California, Irvine, CA 92697, USA.
authors.forename: R R
authors.initials: RR
authors.lastname: Hudson
authors.forename: A G
authors.initials: AG
authors.lastname: Sáez
authors.forename: F J
authors.initials: FJ
authors.lastname: Ayala
mesh_terms: D000818:Animals; D004247:DNA / Q000235:genetics*; D004331:Drosophila melanogaster / Q000235:genetics*; D008040:Genetic Linkage; D011110:Polymorphism, Genetic; D012641:Selection, Genetic; D012689:Sequence Homology, Nucleic Acid; D013482:Superoxide Dismutase / Q000235:genetics*
chemical_list: D004247:DNA; D013482:Superoxide Dismutase