title: Uterine myomas and factors associated with hysterectomy in premenopausal women.
abstract: OBJECTIVE
  Our purpose was to describe clinical characteristics in premenopausal women with uterine myomas and to identify factors associated with hysterectomy.
  
  
  METHODS
  Data were collected by chart abstraction in 421 premenopausal women with myomas and analyzed by univariate and multivariable regression.
  
  
  RESULTS
  Over a median follow-up period of 29 months, 86% of women had symptoms associated with myomas and 40% had an increase in uterine size of > 2 gestational weeks. By multivariable regression, bleeding symptoms at presentation and previous surgical history of cholecystectomy and adhesiolysis were significantly associated with greater odds of hysterectomy. There was a significant interaction between age and uterine size, so that as age increased, uterine size had a greater impact on the likelihood of hysterectomy.
  
  
  CONCLUSIONS
  In this cohort of premenopausal women myomas were associated with symptoms in almost all women over the follow-up period. Hysterectomy was performed in 22% of women overall.
authors.affiliation: Department of Gynecology and Obstetrics, Cleveland Clinic Foundation, OH 44195, USA.
authors.forename: A M
authors.initials: AM
authors.lastname: Weber
authors.forename: A R
authors.initials: AR
authors.lastname: Mitchinson
authors.forename: G P
authors.initials: GP
authors.lastname: Gidwani
authors.forename: E
authors.initials: E
authors.lastname: Mascha
authors.forename: M D
authors.initials: MD
authors.lastname: Walters
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007044:Hysterectomy / Q000592:standards* / Q000706:statistics & numerical data; D016014:Linear Models; D008875:Middle Aged; D015999:Multivariate Analysis; D009214:Myoma / Q000473:pathology / Q000503:physiopathology* / Q000601:surgery*; D017697:Premenopause / Q000502:physiology*; D016016:Proportional Hazards Models; D012307:Risk Factors; D014594:Uterine Neoplasms / Q000473:pathology / Q000503:physiopathology* / Q000601:surgery*; D014599:Uterus / Q000473:pathology / Q000503:physiopathology