title: The effect of glycopyrrolate premedication on postoperative sore throat.
abstract: Patients given general endotracheal anesthesia commonly experience postoperative sore throat and/or hoarseness. Our study examined whether the occurrence of postoperative sore throat was associated with the use of a glycopyrrolate premedication and found that it was. We randomly assigned 120 patients undergoing general endotracheal anesthesia for routine surgery to receive a preoperative mediation including or excluding glycopyrrolate. We controlled for factors known to increase the risk of a postoperative sore throat. After surgery, an interviewer, unaware of the subject's group assignment, questioned each subject about the presence of a sore throat and, if present, asked the patient to rate its severity. We found that patients who did not receive preoperative glycopyrrolate were significantly less likely to report having a sore throat or reported having a less severe sore throat than patients who did receive glycopyrrolate.
authors.affiliation: Hinadale Anesthesia Associates, Illinois, USA.
authors.forename: P A
authors.initials: PA
authors.lastname: Stratelak
authors.forename: W
authors.initials: W
authors.lastname: White
authors.forename: D
authors.initials: D
authors.lastname: Wenzel
mesh_terms: D000759:Adjuvants, Anesthesia / Q000627:therapeutic use*; D000293:Adolescent; D000328:Adult; D000368:Aged; D006024:Glycopyrrolate / Q000627:therapeutic use*; D006801:Humans; D008875:Middle Aged; D010149:Postoperative Pain / Q000188:drug therapy*; D010612:Pharyngitis / Q000188:drug therapy*; D011292:Premedication
chemical_list: D000759:Adjuvants, Anesthesia; D006024:Glycopyrrolate