title: Dedifferentiated acinic cell carcinoma of the parotid gland: a distinct rarely described entity.
abstract: A case of dedifferentiated acinic cell carcinoma of the parotid gland is presented. A 46-year-old man presented with a parotid gland mass. At surgery the tumor was found adherent to the temporal bone and cervical adenopathy was present. Treatment included radical parotidectomy and intraoperative radiotherapy. Histologically, the tumor was a composite of a usual low-grade acinic cell carcinoma and high-grade, poorly differentiated carcinoma. Cervical lymph node metastases were composed entirely of high-grade carcinoma. Immunohistochemically, both low- and high-grade malignant components were negative for p53 oncoprotein expression. Moreover, polymerase chain reaction and nonisotopic single-stranded conformational polymorphism analyses were consistent with a germ line configuration of the p53 gene, exons five through eight, in both low- and high-grade elements of the tumor. The literature on this unusual variant of acinic cell carcinoma is reviewed.
authors.affiliation: Department of Pathology, Rhode Island Hospital and Brown University School of Medicine, Providence 02903, USA.
authors.forename: J D
authors.initials: JD
authors.lastname: Henley
authors.forename: W A
authors.initials: WA
authors.lastname: Geary
authors.forename: C L
authors.initials: CL
authors.lastname: Jackson
authors.forename: C D
authors.initials: CD
authors.lastname: Wu
authors.forename: D R
authors.initials: DR
authors.lastname: Gnepp
mesh_terms: D018267:Carcinoma, Acinar Cell / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D004273:DNA, Neoplasm; D016158:Genes, p53; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D010307:Parotid Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D016133:Polymerase Chain Reaction; D018807:Polymorphism, Single-Stranded Conformational; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism
chemical_list: D004273:DNA, Neoplasm; D016159:Tumor Suppressor Protein p53