title: [Combination chemotherapy of continuous infusion 5-fluorouracil and daily low-dose cisplatin in advanced gastrointestinal and lung adenocarcinoma].
abstract: Continuous intravenous infusion (c.v.i.) of 5-fluorouracil (5-FU) plus daily low-dose cisplatin (CDDP) was evaluated in 45 patients with advanced and recurrent unresected colorectal, lung, gastric and pancreatic adenocarcinoma. 5-FU was given at a dose of 320 mg/m2/day, c.v.i. for 4 weeks, and CDDP between 3.5 to 7 mg/m2/day, infused for one hour five times a week for 4 weeks. Patients received 1 to 3 cycles of treatment (average 1.5 cycle). Pancreatic cancer cases needed longer treatment periods (2.25 cycles). The response rate of colorectal cancer cases was 57.7% (15/26), pancreas cancer 40%, gastric cancer 62.5%, and lung cancer 66.7%. The overall response rate was 57.8%. No severe side effects occurred in any of these cases. These data indicate that this combination 5-FU + daily low-dose CDDP chemotherapy is effective in the treatment of advanced gastrointestinal and lung adenocarcinoma.
authors.affiliation: 1st Dept. of Surgery, Sapporo Medical University, School of Medicine.
authors.forename: K
authors.initials: K
authors.lastname: Sasaki
authors.forename: K
authors.initials: K
authors.lastname: Hirata
authors.forename: R
authors.initials: R
authors.lastname: Denno
authors.forename: I
authors.initials: I
authors.lastname: Oikawa
authors.forename: M
authors.initials: M
authors.lastname: Mukaiya
authors.forename: N
authors.initials: N
authors.lastname: Hiraike
authors.forename: A
authors.initials: A
authors.lastname: Yagihashi
authors.forename: H
authors.initials: H
authors.lastname: Takasaka
authors.forename: T
authors.initials: T
authors.lastname: Katsuramaki
authors.forename: K
authors.initials: K
authors.lastname: Yamashiro
authors.forename: S
authors.initials: S
authors.lastname: Yamamitsu
authors.forename: T
authors.initials: T
authors.lastname: Shirasaka
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy*; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002945:Cisplatin / Q000008:administration & dosage; D003110:Colonic Neoplasms / Q000188:drug therapy*; D004334:Drug Administration Schedule; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D007262:Infusions, Intravenous; D008175:Lung Neoplasms / Q000188:drug therapy*; D008297:Male; D013274:Stomach Neoplasms / Q000188:drug therapy*
chemical_list: D002945:Cisplatin; D005472:Fluorouracil