title: Giant cell arteritis of the uterus: case report and review.
abstract: We here report a rare case of giant cell arteritis (GCA) of the myometrium found incidentally in a 68-year-old Caucasian woman presenting with uterovaginal prolapse and a known past history of temporal arteritis/polymyalgia rheumatica. Histology revealed a segmental arteritis of small, medium and some quite large myometrial arteries with extensive destruction of both internal and external elastic laminae. Multinucleate giant cells, lymphocytes and histiocytes were most prominent in the inflammatory infiltrate. The findings in this case are compared with previous reports. In a review of the literature it was found that almost one third of cases presented with generalised symptoms such as fever, anemia, fatigue and weight loss. The symptoms were not immediately recognised as temporal arteritis or polymyalgia rheumatica. On routine physical examination or radiological investigation, benign gynecological pathology such as a simple ovarian cyst or uterine leiomyoma were found. The subsequent unexpected discovery of GCA on histological examination was the critical event in alerting clinicians to the diagnosis of temporal arteritis/polymyalgia rheumatica. Without exception steroid therapy was successful in achieving relief of generalised symptoms.
authors.affiliation: Central Coast Area Health Service, Gosford, NSW, Australia.
authors.forename: A H
authors.initials: AH
authors.lastname: Ormsby
authors.forename: R
authors.initials: R
authors.lastname: Haskell
mesh_terms: D005260:Female; D013700:Giant Cell Arteritis / Q000473:pathology* / Q000628:therapy; D006801:Humans; D008875:Middle Aged; D014591:Uterine Diseases / Q000473:pathology*