[Seven-year follow-up in pupils immunized with hepatitis B vaccine and its revaccination].
In order to evaluate immune persistence of plasma-derived hepatitis B vaccine (HBV), 344 children in a primary school were followed up for seven years by detection of serum HBsAg, anti-HBc and anti-HBs with radioimmunoassay (RIA) using Abbott reagent kits. In the seventh year after three-dose HBV immunization, level of anti-HBs in 55.4%-75.0% of the vaccinee was greater than 10 IU/L, with a geometric mean titer (GMT) of 20.9-65.3 IU/L. The higher the level of anti-HBs, the longer the duration of its decrease from more than to less than 10 IU/L. Seven years after immunization, 66 children with varied serum levels of anti-HBs were received a fourth dose of 10 micrograms HBV, and one month after revaccination, their levels of anti-HBs increased by 6.3-57.7 times. It suggests revaccination of HBV is not necessary for children vaccinated within seven years.
Li
X
X
Shanghai Institute of Biological Products.
Wu
J
J
Liu
J
J
D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006509:Hepatitis B / Q000517:prevention & control*; D006510:Hepatitis B Antibodies / Q000097:blood; D017325:Hepatitis B Vaccines / Q000276:immunology*; D006801:Humans; D007117:Immunization, Secondary; D008297:Male; D014611:Vaccination
D006510:Hepatitis B Antibodies; D017325:Hepatitis B Vaccines