title: The Bacillus subtilis DivIVA protein targets to the division septum and controls the site specificity of cell division.
abstract: The Bacillus subtilis divIVA gene, first defined by a mutation giving rise to anucleate minicells, has been cloned and characterized. Depletion of DivIVA leads to inhibition of the initiation of cell division. The residual divisions that do occur are abnormally placed and sometimes misorientated relative to the long axis of the cell. The DivIVA phenotype can be suppressed by disruption of the MinCD division inhibitor, suggesting that DivIVA controls the topological specificity of MinCD action and thus septum positioning. A DivIVA-GFP fusion targets to new and used sites of cell division, consistent with it having a direct role in topological specification.
authors.affiliation: Sir William Dunn School of Pathology, University of Oxford, UK.
authors.forename: D H
authors.initials: DH
authors.lastname: Edwards
authors.forename: J
authors.initials: J
authors.lastname: Errington
mesh_terms: D000251:Adenosine Triphosphatases / Q000235:genetics; D000595:Amino Acid Sequence; D001412:Bacillus subtilis / Q000235:genetics / Q000502:physiology*; D001426:Bacterial Proteins / Q000235:genetics / Q000502:physiology*; D001483:Base Sequence; D018797:Cell Cycle Proteins / Q000235:genetics / Q000502:physiology*; D002455:Cell Division / Q000235:genetics / Q000502:physiology; D004269:DNA, Bacterial; D029968:Escherichia coli Proteins; D005798:Genes, Bacterial; D008969:Molecular Sequence Data; D016296:Mutagenesis; D011993:Recombinant Fusion Proteins / Q000235:genetics; D012097:Repressor Proteins / Q000235:genetics
chemical_list: D001426:Bacterial Proteins; D018797:Cell Cycle Proteins; D004269:DNA, Bacterial; C104636:DivIVA protein, bacteria; D029968:Escherichia coli Proteins; D011993:Recombinant Fusion Proteins; D012097:Repressor Proteins; D000251:Adenosine Triphosphatases; C072069:MinD protein, E coli