title: Interferon in viral liver diseases: pharmacological aspects.
abstract: In 1957, two English investigators, Alick Isaacs and Jean Lindenmann made a very important discovery. They observed that when a virus species colonized cells in animals, this invasion interfered with the ability of other viruses, without any association with the former, to produce simultaneous infection. Both investigators observed that the substance responsible for the inhibition was secreted by the infected cells and called it interferon. They also observed that this protein did not directly interact with the virus, but induced the infected cells and surrounding cells to produce other proteins, which were in turn able to block the multiplication of the invading virus.
authors.affiliation: Department of Gastroenterology, Medical School, University of São Paulo.
authors.forename: L C
authors.initials: LC
authors.lastname: da Silva
authors.forename: S K
authors.initials: SK
authors.lastname: Ono
mesh_terms: D006525:Hepatitis, Viral, Human / Q000628:therapy*; D006801:Humans; D007372:Interferons / Q000627:therapeutic use*; D008099:Liver / Q000187:drug effects
chemical_list: D007372:Interferons