title: Propafenone-induced drug fever in the absence of agranulocytosis.
abstract: Propafenone is an antiarrhythmic drug used in the treatment of life-threatening ventricular tachyarrhythmias. Adverse reactions necessitating discontinuation of the medication are common. Propafenone-induced drug fever has not been definitively proven. We present a case report of drug fever secondary to propafenone, confirmed with rechallenge.
authors.affiliation: Department of Cardiology, Dartmouth-Hitchcock Medical Center, Lebanon, NH 03756, USA.
authors.forename: D J
authors.initials: DJ
authors.lastname: O'Rourke
authors.forename: R T
authors.initials: RT
authors.lastname: Palac
authors.forename: P T
authors.initials: PT
authors.lastname: Holzberger
authors.forename: B R
authors.initials: BR
authors.lastname: Gerling
authors.forename: M L
authors.initials: ML
authors.lastname: Greenberg
mesh_terms: D000380:Agranulocytosis / Q000097:blood; D000889:Anti-Arrhythmia Agents / Q000009:adverse effects* / Q000627:therapeutic use; D003937:Diagnosis, Differential; D005334:Fever / Q000097:blood / Q000139:chemically induced* / Q000175:diagnosis; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D011405:Propafenone / Q000009:adverse effects* / Q000627:therapeutic use; D017180:Tachycardia, Ventricular / Q000188:drug therapy*
chemical_list: D000889:Anti-Arrhythmia Agents; D011405:Propafenone