(1 alpha, 2 beta, 3 beta, 4 alpha)-1,2-bis[N-propyl-N-(4-phenoxybenzyl) amino]carbonyl]cyclobutane-3,4-dicarboxylic acid (A-87049): a novel potent squalene synthase inhibitor.
Fung
A K
AK
Aging and Degenerative Diseases Research, Pharmaceutical Discovery, Abbott Laboratories, Illinois 60064-3500, USA.
Baker
W R
WR
Fakhoury
S
S
Stein
H H
HH
Cohen
J
J
Donner
B G
BG
Garvey
D S
DS
Spina
K P
KP
Rosenberg
S H
SH
D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D000924:Anticholesteremic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003998:Dicarboxylic Acids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013186:Farnesyl-Diphosphate Farnesyltransferase / Q000037:antagonists & inhibitors*; D005260:Female; D007202:Indicators and Reagents; D008148:Lovastatin / Q000494:pharmacology; D008252:Macaca fascicularis; D008297:Male; D015394:Molecular Structure; D013329:Structure-Activity Relationship
C106946:A 87049; D000577:Amides; D000924:Anticholesteremic Agents; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D003998:Dicarboxylic Acids; D004791:Enzyme Inhibitors; D007202:Indicators and Reagents; D002784:Cholesterol; D008148:Lovastatin; D013186:Farnesyl-Diphosphate Farnesyltransferase