Age-of-onset related HLA-DQA1 genetic heterogeneity of insulin-dependent diabetes mellitus.
OBJECTIVE
To clarify whether there is an association of insulin-dependent diabetes mellitus (IDDM) susceptibility with HLA-DQA1 locus in adult-onset IDDM.


METHODS
Possible heterogeneity in immunogenetic aspects was investigated by comparing the findings on relationship between HLA-DQA1 52 Arg(+) and IDDM predisposition in three groups with different ages of IDDM onset (group A 14 years, group B 15-30 years, group C > 31 years).


RESULTS
The frequency of HLA-DQA1 52 Arg(+) in group A (87.5%) was higher than that in control (53.9%, P < 0.05) and in group B and C (P < 0.05). The frequency of HLA-DQA1 52 Arg(+)/Arg(+) phenotype in group A (75%) was higher than that in group C (23.1%, P < 0.05).


CONCLUSIONS
The contribution of HLA-DQA1 52 arginine to IDDM susceptibility is heterogeneous. Further study is necessary to clarify the immunogenetic entity of IDDM.
Cheng
H
H
Department of Endocrinology, Memorial Hospital, Sun Yat-Sen University of Medical Sciences, Guangzhou.
Zhang
Y
Y
Fu
Z
Z
Yan
T
T
D000328:Adult; D017668:Age of Onset; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics* / Q000276:immunology; D004198:Disease Susceptibility; D005260:Female; D018740:Genetic Heterogeneity; D006683:HLA-DQ Antigens / Q000235:genetics*; D059848:HLA-DQ alpha-Chains; D006801:Humans; D008297:Male; D008875:Middle Aged
D006683:HLA-DQ Antigens; D059848:HLA-DQ alpha-Chains; C069050:HLA-DQA1 antigen