Frequency of associated anomalies in congenital hypoplasia of depressor anguli oris muscle: a study of 50 patients.
Aside from congenital heart disease, anomalies associated with unilateral hypoplasia of the depressor anguli oris muscle have not been well-documented in large series. We evaluated the associated anomalies in 50 infants or children with this disorder (male:female = 2:1) and found accompanying anomalies in 35 (70%) of 50 cases. They included anomalies of the head and neck (48%), heart (44%), skeleton (22%), genitourinary tract (24%), central nervous system (10%), gastrointestinal tract (6%), and miscellaneous minor anomalies (8%). Nearly half of our cases (22/50) had at least 2 associated systemic anomalies. Failure to thrive and psychomotor retardation were found in 5 (10%) and 3 (6%) patients, respectively, on follow-up. Three infants died neonatally of severe heart disorders, and the other one died of central nervous system anomalies. The above findings indicate that a thorough search for associated anomalies, particularly in the cardiovascular system, should be performed in all newborns with asymmetric crying face.
Lin
D S
DS
Department of Paediatrics, Mackay Memorial Hospital, Taipei, Taiwan.
Huang
F Y
FY
Lin
S P
SP
Chen
M R
MR
Kao
H A
HA
Hung
H Y
HY
Hsu
C H
CH
D000015:Abnormalities, Multiple / Q000235:genetics*; D005146:Facial Asymmetry / Q000151:congenital* / Q000235:genetics; D005152:Facial Muscles / Q000002:abnormalities*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007621:Karyotyping; D008297:Male; D010641:Phenotype; D013577:Syndrome