title: Proximal-distal axis formation in the Drosophila leg.
abstract: Limb development requires the formation of a proximal-distal axis perpendicular to the main anterior-posterior and dorsal-ventral body axes. The secreted signalling proteins Decapentaplegic and Wingless act in a concentration-dependent manner to organize the proximal-distal axis. Discrete domains of proximal-distal gene expression are defined by different thresholds of Decapentaplegic and Wingless activities. Subsequent modulation of the relative sizes of these domains by growth of the leg is required to form the mature pattern.
authors.affiliation: European Molecular Biology Laboratory, Heidelberg, Germany.
authors.forename: T
authors.initials: T
authors.lastname: Lecuit
authors.forename: S M
authors.initials: SM
authors.lastname: Cohen
mesh_terms: D000818:Animals; D019521:Body Patterning / Q000235:genetics / Q000502:physiology*; D004330:Drosophila / Q000196:embryology* / Q000235:genetics; D029721:Drosophila Proteins; D004627:Embryonic Induction; D005121:Extremities / Q000196:embryology; D018507:Gene Expression Regulation, Developmental; D018398:Homeodomain Proteins / Q000235:genetics / Q000378:metabolism; D019476:Insect Proteins / Q000502:physiology*; D009687:Nuclear Proteins / Q000235:genetics / Q000378:metabolism; D011518:Proto-Oncogene Proteins / Q000502:physiology*; D015398:Signal Transduction; D051155:Wnt1 Protein
chemical_list: D029721:Drosophila Proteins; D018398:Homeodomain Proteins; D019476:Insect Proteins; D009687:Nuclear Proteins; D011518:Proto-Oncogene Proteins; D051155:Wnt1 Protein; C103968:dac protein, Drosophila; C064196:dpp protein, Drosophila; C074622:wg protein, Drosophila