Plasmodium yoelii: resistance to disease is linked to the mtv-7 locus in BALB/c mice.
We have identified congenic mouse strains that differ dramatically in resistance to infection with the murine malaria parasite Plasmodium yoelii 17X. After infection, BALB/c mice develop severe anemia and a high degree of parasitemia which sometimes results in death. The mtv-7 congenic strain BALB.D2.mlsa, however, develops only a mild degree of anemia and parasitemia. In this paper we describe the course of the disease and discuss the potential role of mtv-7 and linked loci in control of this infection. These mice differ in their response to anemia, which may contribute to their differential susceptibility to disease; however, no influence of mtv-7 reactive T cells was documented.
Swardson
C J
CJ
Department of Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins 80523, USA.
Wassom
D L
DL
Avery
A C
AC
D000740:Anemia / Q000209:etiology / Q000235:genetics / Q000276:immunology; D000818:Animals; D000956:Antigens, Viral / Q000235:genetics*; D003433:Crosses, Genetic; D004920:Erythropoiesis / Q000276:immunology; D007113:Immunity, Innate / Q000235:genetics; D008288:Malaria / Q000150:complications / Q000235:genetics / Q000276:immunology*; D008324:Mammary Tumor Virus, Mouse / Q000235:genetics / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C / Q000235:genetics* / Q000276:immunology; D008819:Mice, Nude; D018512:Parasitemia / Q000150:complications / Q000235:genetics / Q000276:immunology*; D010967:Plasmodium yoelii / Q000276:immunology*; D018089:Superantigens / Q000235:genetics*; D013601:T-Lymphocytes / Q000276:immunology
D000956:Antigens, Viral; D018089:Superantigens