Cytotoxic acylated Spermidine from a soft coral, Sinularia sp.
A cytotoxic acylated spermidine was isolated from a Pacific soft coral, Sinularia sp. and its structure determined by NMR and mass spectral analysis. The acyl portion corresponds to (3E)-5-methyltetradec-3-enoic acid.
Choi
Y H
YH
Department of Chemistry and Biochemistry, University of Oklahoma, Norman, USA.
Schmitz
F J
FJ
D000818:Animals; D000970:Antineoplastic Agents / Q000302:isolation & purification* / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D003063:Cnidaria / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D005229:Fatty Acids, Monounsaturated / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D007941:Leukemia P388 / Q000188:drug therapy; D009682:Magnetic Resonance Spectroscopy; D013095:Spermidine / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology
D000970:Antineoplastic Agents; D005229:Fatty Acids, Monounsaturated; C106393:N-(N-methyl-N-(N,N-dimethylaminobutyl)aminopropyl)-5-methyltetradecen-3-enamide; D013095:Spermidine