Primary B-cell lymphomas of the skin.
Primary B-cell lymphomas of the skin are not as rare as is generally believed. They are defined as malignant B-cell proliferations presenting with cutaneous involvement alone and no evidence of extracutaneous manifestations over a period of at least six months when complete staging has been performed. The major subtypes are follicle center-cell lymphoma of the head and trunk, immunocytoma and large B-cell lymphoma of the leg (EORTC classification 1996). Also of interest is the recently recognized marginal-zone B-cell lymphoma. Primary B-cell lymphomas of the skin differ significantly from nodal lymphomas. Awareness of their special clinical behavior should prevent unnecessarily aggressive treatment.
Kerl
H
H
Department of Dermatology, University of Graz, Austria.
Cerroni
L
L
D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000145:classification; D008223:Lymphoma / Q000145:classification; D016393:Lymphoma, B-Cell / Q000145:classification* / Q000628:therapy; D010954:Plasmacytoma / Q000145:classification; D011379:Prognosis; D012878:Skin Neoplasms / Q000145:classification* / Q000628:therapy