title: Neuromuscular blocking actions of the aminoglycoside antibiotics sisomicin and micronomicin in the rabbit.
abstract: The neuromuscular blocking actions of sisomicin sulfate (SISO), micronomicin sulfate (MCR) and d-tubocurarine (dTc) were studied in 20 rabbits anesthetized with halothane. The i.v. administration of SISO 20-40 mg/kg, MCR 40-80 mg/kg or dTc 0.1-0.3 mg/kg resulted in dose-dependent decreases in twitch tension. The ED50s for SISO, MCR and dTc were 23.5, 58.2 and 0.2 mg/kg, respectively. SISO- and MCR-induced neuromuscular blockade was partially antagonized by neostigmine or by calcium.
authors.affiliation: Division of Intensive Care Medicine, Tohoku University Hospital, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Matsukawa
authors.forename: J H
authors.initials: JH
authors.lastname: Suh
authors.forename: Y
authors.initials: Y
authors.lastname: Hashimoto
authors.forename: M
authors.initials: M
authors.lastname: Kato
authors.forename: D
authors.initials: D
authors.lastname: Satoh
authors.forename: S
authors.initials: S
authors.lastname: Saito
authors.forename: K
authors.initials: K
authors.lastname: Endo
authors.forename: T
authors.initials: T
authors.lastname: Saishu
mesh_terms: D000617:Aminoglycosides; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D002118:Calcium / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005839:Gentamicins; D009119:Muscle Contraction / Q000187:drug effects; D009388:Neostigmine / Q000494:pharmacology; D009466:Neuromuscular Blocking Agents / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D011817:Rabbits; D012853:Sisomicin / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D014403:Tubocurarine / Q000008:administration & dosage / Q000494:pharmacology
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D005839:Gentamicins; D009466:Neuromuscular Blocking Agents; D009388:Neostigmine; C037545:micronomicin; D002118:Calcium; D014403:Tubocurarine; D012853:Sisomicin