[Intercellular interactions during the healing of an experimental skin wound].
On the model of skin wound in white rats in the dynamics of wound process the interaction of mast cells and fibroblasts was studied. Quantitative, morphological and functional changes of mast cells, the content of free and total histamine and serotonin, the reaction of fibroblasts in the focus of skin lesion during 20 days after injury were investigated. It was established that the mast cells played an important role not only in the early inflammatory phase but also in the later time of wound process. An increase in the mast cells count, in their functional activity, in free and total histamine and serotonin content during the reparative phase of wound process corresponding to the fibroblast reaction was observed. The increase in the mast cells number, the greatest release and accumulation of biogenic amines were paralleled by simultaneous increase in the fibroblast count, enhanced forming of new connective tissue, by drastic reduction of the area wound. The possible mechanisms of mast cells and fibroblasts interaction in the reparative phase of wound process are discussed.
Lipshits'
R U
RU
Zviahintseva
T V
TV
D000818:Animals; D002450:Cell Communication / Q000502:physiology*; D004195:Disease Models, Animal; D005347:Fibroblasts / Q000473:pathology / Q000502:physiology; D006632:Histamine / Q000502:physiology; D008407:Mast Cells / Q000473:pathology / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D012701:Serotonin / Q000502:physiology; D012867:Skin / Q000293:injuries* / Q000503:physiopathology; D013997:Time Factors; D014945:Wound Healing / Q000502:physiology*
D012701:Serotonin; D006632:Histamine