[A comparative study of fluoroquinolones and 3rd-generation cephalosporins in the prevention and treatment of experimental plague caused by Yersinia pestis strains typical and serologically atypical with respect to F1].
Fluoroquinolones (ciprofloxacin and pefloxacin) and 3rd generation cephalosporins (cefoperazone, cefotaxime, ceftazidime and ceftriaxone) were comparatively studied in the prevention and treatment of experimental plague in albino mice caused by F1+ and F1- strains of the plague microbe. Despite the phenotype of the strain which caused the infection, the drugs were highly efficient in the etiotropic therapy. However, in the experimental plague due to F1- strains it was needed to use the maximum mean daily doses of the fluoroquinolones, cefoperazone and cefotaxime. For the prevention of the infection such doses should be used for not less than 7 days. By the efficacy ceftriaxon was superior to the other cephalosporins and should be considered as a drug of choice.
Ryzhko
I V
IV
Shcherbaniuk
A I
AI
Tsuraeva
R I
RI
Samokhodkina
E D
ED
Kasatkina
I V
IV
Tsetskhladze
N S
NS
Pasiukov
V V
VV
Roshchina
N V
NV
D000818:Animals; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D000942:Antigens, Bacterial / Q000276:immunology*; D016667:Bacterial Capsules / Q000276:immunology*; D002511:Cephalosporins / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D024841:Fluoroquinolones; D051379:Mice; D010930:Plague / Q000188:drug therapy* / Q000382:microbiology / Q000517:prevention & control*; D013997:Time Factors; D015010:Yersinia pestis / Q000276:immunology / Q000472:pathogenicity*
D000890:Anti-Infective Agents; D000942:Antigens, Bacterial; D002511:Cephalosporins; D024841:Fluoroquinolones