title: Thermal effects of acrylic cementation at bone tumour sites.
abstract: The use of acrylic bone cement as an adjunct to surgical excision of giant cell tumour of bone appears to reduce the incidence of tumour recurrence. Possible mechanisms for this apparent tumour inhibition include cytotoxic effects from the methylmethacrylate monomer and tissue hyperthermia from the heat of polymerization of the cement. This work presents a method for the prediction of temperature fields and resulting tissue necrosis arising from the implantation of polymethylmethacrylate (PMMA) at the site of a curretted giant cell tumour of bone. This is accomplished using a two-dimensional model based on geometry obtained from digitized MRI images of the distal femur. A general-coordinate, non-orthogonal grid generation technique is used and solutions are obtained with an alternating-direction implicit (ADI) finite-difference scheme. The nodal temperature histories are then used to evaluate the effect of variable defect size on the zone of thermally induced cell necrosis. The results suggest the depth of the necrotic region is quite sensitive to the size of the implant. In at least some cases, the heating effect is sufficient to cause significant necrosis of tumorigenic cells. Implanting a large mass of acrylic may risk overkill, damaging substantial amounts of healthy tissue.
authors.affiliation: Mechanical Engineering-Engineering Mechanics Department, Michigan Technological University, Houghton 49931, USA.
authors.forename: D A
authors.initials: DA
authors.lastname: Nelson
authors.forename: M E
authors.initials: ME
authors.lastname: Barker
authors.forename: B H
authors.initials: BH
authors.lastname: Hamlin
mesh_terms: D001843:Bone Cements / Q000009:adverse effects / Q000627:therapeutic use*; D001859:Bone Neoplasms / Q000473:pathology / Q000601:surgery / Q000628:therapy*; D003131:Combined Modality Therapy; D004343:Drug Implants; D005266:Femoral Neoplasms / Q000473:pathology / Q000601:surgery / Q000628:therapy; D005269:Femur / Q000473:pathology; D018212:Giant Cell Tumor of Bone / Q000473:pathology / Q000601:surgery / Q000628:therapy*; D006801:Humans; D006979:Hyperthermia, Induced / Q000009:adverse effects / Q000379:methods*; D008433:Mathematics; D008768:Methylmethacrylates / Q000009:adverse effects / Q000627:therapeutic use; D008954:Models, Biological; D009336:Necrosis; D013696:Temperature
chemical_list: D001843:Bone Cements; D004343:Drug Implants; D008768:Methylmethacrylates