Extended intravascular shunting in an experimental model of vascular injury.
OBJECTIVE
To examine the extended patency (> 24 hrs) of heparin-bonded intravascular shunts in a porcine model of vascular injury.


METHODS
Adult swine underwent bilateral, common iliac artery resection (n = 5) or bilateral common iliac vein resection (n = 5) and vessel replacement with interposition, heparin-bonded shunts. Three control swine had vessel dissection only. Hematologic and coagulation profiles were measured at baseline and 24 hrs. Limb perfusion was assessed at 24 hrs by clinical exam and angiography.


RESULTS
At 24 hrs, all limbs in both shunt groups were well perfused. All arterial shunts were angiographically patent. No distal emboli were detected. Nine of 10 venous shunts were patent, seven were lined with non-occluding thrombus. No alterations in hematologic or coagulation profiles were noted.


CONCLUSIONS
Heparin-bonded shunts remained patent in arteries for 24 hours. Shunts placed in the venous system were prone to thrombus formation but most remained patent.
Aldridge
S D
SD
Department of Surgery, Temple University School of Medicine, Philadelphia, PA, USA.
Badellino
M M
MM
Malaspina
P J
PJ
Milner
R E
RE
Warren
R
R
Comerota
A J
AJ
Buckman
R F
RF
D000818:Animals; D001166:Arteriovenous Shunt, Surgical / Q000295:instrumentation*; D002404:Catheterization / Q000295:instrumentation; D006493:Heparin; D007083:Iliac Artery / Q000293:injuries*; D007084:Iliac Vein / Q000293:injuries*; D011143:Polyvinyl Chloride; D013552:Swine; D013927:Thrombosis / Q000517:prevention & control*; D013997:Time Factors; D014654:Vascular Patency
D011143:Polyvinyl Chloride; D006493:Heparin