[Neisseria meningitidis strains with decreased susceptibility to penicillin and ampicillin].
Thirty-eight patients (31 children and 7 adults) with meningococcal infection (sepsis and/or meningitis) were studied. The strain most frequently isolated was B (44.7%), followed by C (31.6%). Of the strains isolated, 52.6% were moderately resistant to penicillin (91.6% if only strain C was considered). No resistance to cephotaxime or chloramphenicol was found. Even though patients with moderately resistant strains treated with penicillin G evolved satisfactorily (minimum inhibitory concentrations 0.12-0.50 microgram/ml), the possible appearance of more resistant strains and/or of strains that produce beta-lactamase leads us to the conclusion that cephotaxime is the treatment of choice until an antibiogram is available.
Quiles Durá
J L
JL
Servicio de Pediatría, Hospital General Universitario de Elche.
Rico Urios
C
C
Climent Forner
E
E
Fuentes Campos
E
E
Royo García
G
G
Vargas Torcal
F
F
D000293:Adolescent; D000328:Adult; D000368:Aged; D000667:Ampicillin / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D004342:Drug Hypersensitivity / Q000209:etiology*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D016920:Meningitis, Bacterial / Q000188:drug therapy / Q000209:etiology*; D008875:Middle Aged; D009345:Neisseria meningitidis / Q000472:pathogenicity*; D010406:Penicillins / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D012189:Retrospective Studies
D010406:Penicillins; D000667:Ampicillin