Development of somatostatin radioimmunoassay for the measurement of plasma and tissue contents of hormone.
A specific and sensitive radioimmunoassay was developed in our laboratory for measuring plasma and tissue somatostatin levels. The hormone content of arterial blood and skin samples of untreated and mustard oil (a specific agent causing neurogenic inflammation) treated animals was detected by this method. The somatostatin level of the inflamed tissue was significantly higher, but no difference was found between the plasma concentrations.
Németh
J
J
Department of Pharmacology, University Medical School of Pécs, Hungary.
Helyes
Z
Z
Görcs
T
T
Gardi
J
J
Pintér
E
E
Szolcsányi
J
J
D000818:Animals; D001774:Blood Chemical Analysis / Q000379:methods*; D003872:Dermatitis / Q000209:etiology / Q000378:metabolism; D009149:Mustard Plant; D009422:Nervous System Diseases / Q000139:chemically induced / Q000150:complications; D010936:Plant Extracts / Q000494:pharmacology; D010938:Plant Oils; D011863:Radioimmunoassay / Q000379:methods*; D051381:Rats; D017208:Rats, Wistar; D012680:Sensitivity and Specificity; D012867:Skin / Q000737:chemistry* / Q000187:drug effects; D013004:Somatostatin / Q000032:analysis* / Q000097:blood*
D010936:Plant Extracts; D010938:Plant Oils; D013004:Somatostatin; C027793:mustard oil