title: Transient down-regulation of inhibin-betaC expression following partial hepatectomy.
abstract: Inhibin-betaC is a recently described TGF-beta family member most homologous to inhibin-betaA and inhibin-betaB. By Northern analysis, inhibin-betaC mRNA was detected exclusively in the liver among a large number of adult mouse tissues surveyed. The expression of inhibin-betaC mRNA in adult liver dropped sharply and transiently following partial hepatectomy. At 6 and 12 hours following partial hepatectomy, the levels of inhibin-betaC mRNA were at least 8-fold lower than in control animals. The liver specificity of inhibin-betaC expression and its down-regulation following partial hepatectomy suggest that inhibin-betaC may function as a negative regulator of liver growth.
authors.affiliation: Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
authors.forename: A F
authors.initials: AF
authors.lastname: Esquela
authors.forename: T A
authors.initials: TA
authors.lastname: Zimmers
authors.forename: L G
authors.initials: LG
authors.lastname: Koniaris
authors.forename: J V
authors.initials: JV
authors.lastname: Sitzmann
authors.forename: S J
authors.initials: SJ
authors.lastname: Lee
mesh_terms: D000818:Animals; D005260:Female; D015971:Gene Expression Regulation, Enzymologic; D006498:Hepatectomy; D007265:Inhibins / Q000096:biosynthesis; D007700:Kinetics; D008099:Liver / Q000378:metabolism*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009928:Organ Specificity; D010452:Peptide Biosynthesis; D029584:Prostatic Secretory Proteins
chemical_list: D029584:Prostatic Secretory Proteins; C043076:beta-microseminoprotein; D007265:Inhibins