The combined value of chemoprophylaxis and pneumococcal vaccine in the prevention of recurrent pneumococcal meningitis.
We report the case of an immunocompetent patient who has been the subject of 39 episodes of recurrent pneumococcal meningitis over a 20 year period. The recurrences of bacterial meningitis due to cerebrospinal fluid leakage and the presence of chronic sinusitis were not influenced by the surgical repair of a fistula and the repeated surgical draining interventions on suppurating chronic sinusital foci. Phenoxymethylpenicillin treatment reduced the number of recurrences and the combination of pneumococcal vaccine and penicillin prophylaxis allowed a 5 year period free of any recurrences.
Hristea
A
A
University Clinic of Infectious Diseases, N Gh Lupu Hospital, Bucharest, Romania.
Chiotan
M
M
Tudose
M
M
Mihalcu
F
F
D000293:Adolescent; D001428:Bacterial Vaccines / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008586:Meningitis, Pneumococcal / Q000517:prevention & control*; D010404:Penicillin V / Q000627:therapeutic use*; D010406:Penicillins / Q000627:therapeutic use*; D012008:Recurrence; D013296:Streptococcus pneumoniae / Q000276:immunology*
D001428:Bacterial Vaccines; D010406:Penicillins; D010404:Penicillin V