The effect of Syzygium cumini (L.) skeels on post-prandial blood glucose levels in non-diabetic rats and rats with streptozotocin-induced diabetes mellitus.
This study was undertaken to investigate whether a tea prepared from Syzygium cumini, reported to be used by diabetics in Porto Alegre, Brazil, might have an antihyperglycemic effect in experimental models. Teas prepared from leaves and seeds of S. cumini, in concentrations ranging from 2-64 g/l, were administered, as water substitute for 14-95 days, to 16 groups with 8-9 normal albino rats and to four groups with 10-12 rats with streptozotocin-induced diabetes mellitus. Post-prandial blood glucose levels were determined by the glucose oxidase method on blood samples obtained by decapitation. None of the tea concentration had any detectable antihyperglycemic effect either in normal or in diabetic rats, suggesting that this plant, prepared in a manner similar to that employed by humans, is destitute of an antihyperglycemic effect.
Teixeira
C C
CC
Departmento de Farmacologia, Universidade Federal, Rio Grande do Sul, Brazil.
Pinto
L P
LP
Kessler
F H
FH
Knijnik
L
L
Pinto
C P
CP
Gastaldo
G J
GJ
Fuchs
F D
FD
D000818:Animals; D001628:Beverages; D001786:Blood Glucose / Q000378:metabolism*; D001938:Brazil; D003921:Diabetes Mellitus, Experimental / Q000097:blood* / Q000628:therapy*; D005260:Female; D007004:Hypoglycemic Agents / Q000302:isolation & purification / Q000494:pharmacology; D008519:Medicine, Traditional; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal; D051381:Rats
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D010936:Plant Extracts