title: In vitro antimicrobial activity of the thiazolyl peptide antibiotic MDL 62,879 (GE2270 A).
abstract: Compound MDL 62,879 (GE2270 A) is a thiazolyl peptide antibiotic that appears to inhibit aminoacyl-tRNA binding to elongation factor Tu. In the present study, it was shown that MDL 62,879 broth microdilution MIC values were generally 2-4 doubling dilutions lower in the presence of 0.02% bovine serum albumin. Using US clinical isolates and BSA-supplemented media, MDL 62,879 was more active than teicoplanin and vancomycin against the staphylococci and glycopeptide-resistant and glycopeptide-susceptible enterococci and equally active against the streptococci. Broth microdilutions MIC values were not appreciably affected by inoculum concentrations of 5 x 10(4) to 5 x 10(8) cfu/ml or in the presence of 3.5% human serum albumin.
authors.affiliation: Hoechst Marion Roussel, Kansas City, Mo. 64134, USA.
authors.forename: M T
authors.initials: MT
authors.lastname: Kenny
authors.forename: M A
authors.initials: MA
authors.lastname: Brackman
authors.forename: J K
authors.initials: JK
authors.lastname: Dulworth
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D010456:Peptides, Cyclic / Q000494:pharmacology; D017334:Teicoplanin / Q000494:pharmacology; D013844:Thiazoles / Q000494:pharmacology; D014640:Vancomycin / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D010456:Peptides, Cyclic; D013844:Thiazoles; D017334:Teicoplanin; D014640:Vancomycin; C068122:GE 2270 A