title: The effect of a thiamin derivative on exercise performance.
abstract: The purpose of this study was to investigate the effect of a thiamin derivative, thiamin tetrahydrofurfuryl disulfide (TTFD), on oxygen uptake (VO2), lactate accumulation and cycling performance during exercise to exhaustion. Using a randomized, double-blind, cross-over design with a 10-day washout between trials, 14 subjects ingested either 1 g.day-1 of TTFD or a placebo (PL) for 4 days. On day 3, subjects performed a progressive exercise-test to exhaustion on a cycle ergometer for the determination of VO2submax, VO2peak, lactate concentration ([La-]), lactate threshold (ThLa) and heart rate (fc). On day 4, subjects performed a maximal 2000-m time trial on a cycle ergometer. A one-way analysis of variance (ANOVA) with repeated measures was used to determine significant differences between trials. There were no significant differences detected between trials for serial measures of VO2submax, [La-] or fc. Likewise, VO2peak [PL 4.06 (0.19) TTFD 4.12 (0.19) l.min-1, P = 0.83], ThLa [PL 2.47 (0.17), TTFD 2.43 (0.16) l.min-1, P = 0.86] and 2000-m performance time [PL 204.5 (5.5), TTFD 200.9 (4.3).s, P = 0.61] were not significantly different between trials. The results of this study suggest that thiamin derivative supplementation does not influence high-intensity exercise performance.
authors.affiliation: Department of Physical Education, Western Illinois University, Macomb 61455, USA.
authors.forename: M J
authors.initials: MJ
authors.lastname: Webster
authors.forename: T P
authors.initials: TP
authors.lastname: Scheett
authors.forename: M R
authors.initials: MR
authors.lastname: Doyle
authors.forename: M
authors.initials: M
authors.lastname: Branz
mesh_terms: D000328:Adult; D018592:Cross-Over Studies; D004311:Double-Blind Method; D015444:Exercise / Q000502:physiology*; D005260:Female; D005666:Fursultiamin / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D019344:Lactic Acid / Q000378:metabolism; D008297:Male; D010101:Oxygen Consumption / Q000187:drug effects
chemical_list: D005666:Fursultiamin; D019344:Lactic Acid