alpha 1-Antichymotrypsin as a risk modifier for late-onset Alzheimer's disease in Japanese apolipoprotein E epsilon 4 allele carriers.
In the Japanese population, sporadic late-onset Alzheimer's disease (LOAD) cases had significantly higher frequencies of the A allele of alpha 1-antichymotrypsin (ACT) gene as well as the epsilon 4 allele of apolipoprotein E (APOE) gene than controls. The odds ratio for LOAD in APOE4 carriers with the ACT-A allele was more than six times that in APOE4 carriers without the ACT-A allele (21.1 vs 3.2). These results indicate that the ACT-A allele is a risk modifier for LOAD in APOE4 carriers.
Yoshiiwa
A
A
Department of Geriatric Medicine, Osaka University Medical School, Kohsaün Hospital, Japan.
Kamino
K
K
Yamamoto
H
H
Kobayashi
T
T
Imagawa
M
M
Nonomura
Y
Y
Yoneda
H
H
Sakai
T
T
Nishiwaki
Y
Y
Sato
N
N
Rakugi
H
H
Miki
T
T
Ogihara
T
T
D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D000544:Alzheimer Disease / Q000097:blood* / Q000453:epidemiology / Q000235:genetics*; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics*; D005260:Female; D006579:Heterozygote; D006801:Humans; D008297:Male; D012307:Risk Factors; D000514:alpha 1-Antichymotrypsin / Q000097:blood*
D053327:Apolipoprotein E4; D001057:Apolipoproteins E; D000514:alpha 1-Antichymotrypsin