The effects of 50 Hz magnetic field exposure on dimethylbenz(alpha)anthracene induced thymic lymphoma/leukemia in mice.
Several epidemiological investigations have suggested an increased incidence of lymphoma, leukemia, and brain tumor in residents living near power transmission lines. However, some observers failed to confirm such a positive correlation. To evaluate the effects of extremely low frequency (ELF) magnetic fields on leukemogenesis, an experimental animal model was used, in which thymic lymphoma/leukemia was induced by dimethylbenz(alpha)anthracene (DMBA) injected subcutaneously into the interscapular region of newborn mice within 24 h after birth. Beginning at the second week of age, 165 mice were exposed to 50 Hz magnetic field at 1 mT, 3 h/day, 6 days/week for 16 weeks, and 155 animals exposed to sham conditions. All surviving animals were killed by cervical dislocation at the age of 32 weeks and were examined pathologically. The results showed that the incidences of advanced thymic lymphoma, complicated with lymphomatous leukemia, were 21.8 and 23.9% in the two groups, respectively, without statistically significant differences. But dense metastatic infiltration by lymphoma cells into liver in the field exposure group greater (50%) than that in the sham-exposure group (16.2%) was observed (chi 2 = 9.847, P < 0.01). To determine whether ELF acts as a tumor promoter, further experiments are required.
Shen
Y H
YH
Microwave Institute, Zhejiang Medical University, Hangzhou, People's Republic of China.
Shao
B J
BJ
Chiang
H
H
Fu
Y D
YD
Yu
M
M
D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D002273:Carcinogens; D004574:Electromagnetic Fields; D007942:Leukemia, Experimental / Q000139:chemically induced / Q000473:pathology*; D007951:Leukemia, Myeloid / Q000139:chemically induced / Q000473:pathology; D008113:Liver Neoplasms / Q000473:pathology / Q000556:secondary; D008223:Lymphoma / Q000139:chemically induced / Q000473:pathology*; D051379:Mice; D009362:Neoplasm Metastasis; D013160:Splenic Neoplasms / Q000473:pathology / Q000556:secondary; D013953:Thymus Neoplasms / Q000139:chemically induced / Q000473:pathology*
D002273:Carcinogens; D015127:9,10-Dimethyl-1,2-benzanthracene