title: Drug quantitation on a benchtop liquid chromatography-tandem mass spectrometry system.
abstract: The specificity and selectivity of LC-MS-MS is illustrated to explain why LC-MS-MS has become the method of choice for quantitation within the pharmaceutical industry. Two assays are described that demonstrate the facility with which new ion trap technology can utilize the selectivity and sensitivity of LC-MS-MS to quantitate trace level components within complex matrices, in particular human plasma. One assay undergoes a validation procedure and demonstrates the utility of this new technology for drug quantitation within a regulated environment.
authors.affiliation: Finnigan MAT, San Jose, CA 95134, USA.
authors.forename: P R
authors.initials: PR
authors.lastname: Tiller
authors.forename: J
authors.initials: J
authors.lastname: Cunniff
authors.forename: A P
authors.initials: AP
authors.lastname: Land
authors.forename: J
authors.initials: J
authors.lastname: Schwartz
authors.forename: I
authors.initials: I
authors.lastname: Jardine
authors.forename: M
authors.initials: M
authors.lastname: Wakefield
authors.forename: L
authors.initials: L
authors.lastname: Lopez
authors.forename: J F
authors.initials: JF
authors.lastname: Newton
authors.forename: R D
authors.initials: RD
authors.lastname: Burton
authors.forename: B M
authors.initials: BM
authors.lastname: Folk
authors.forename: D L
authors.initials: DL
authors.lastname: Buhrman
authors.forename: P
authors.initials: P
authors.lastname: Price
authors.forename: D
authors.initials: D
authors.lastname: Wu
mesh_terms: D002138:Calibration; D002853:Chromatography, Liquid / Q000379:methods*; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D013058:Mass Spectrometry / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013739:Testosterone / Q000097:blood*; D013844:Thiazoles / Q000032:analysis
chemical_list: D013844:Thiazoles; D013739:Testosterone; C071317:Foropafant; D006854:Hydrocortisone