title: Comparison of the Gyro C1E3 and BioMedicus centrifugal pump performances during cardiopulmonary bypass.
abstract: The compact eccentric inlet port (C1E3) centrifugal blood pump was developed as a cardiopulmonary bypass (CPB) pump. The C1E3 pump incorporated a sealless design with a blood stagnation free structure. The pump impeller was magnetically coupled to the driver magnet in a sealless manner. To develop an atraumatic and antithrombogenic centrifugal pump without a shaft seal junction, a double pivot bearing system was introduced. Recently, a mass production model of the C1E3 was fabricated and evaluated. The ratio of the normalized index of hemolysis (NIH) of the C1E3 was 0.007 g/ 100 L, in comparison to the NIH of the BP-80, 0.018 g/ 100 L, each in a CPB condition of 5 L/min against 325 mm Hg. Both pumps were compared in identical in vitro circuits. To further evaluate the pumps during cardiopulmonary bypass for reliability and function, 6 h of CPB was performed on each of 8 bovines using either the C1E3 or BP-80 centrifugal pump. The BP-80 and C1E3 provided pump flows of 50-60 ml/kg/min without incident. The hemodynamics were stable, and the hematology and biochemistry data were within normal ranges. There were no statistically significant differences between the 2 groups. Concerning the plasma free hemoglobin values, a mass production model of the C1E3 pump had the same hemolysis levels as the BP-80. Our preliminary studies reveal that the C1E3 pump is reliable. Also, the C1E3 will satisfy clinical requirements as a cardiopulmonary bypass pump.
authors.affiliation: Department of Surgery, Baylor College of Medicine, Houston, Texas, USA.
authors.forename: T
authors.initials: T
authors.lastname: Nakazawa
authors.forename: Y
authors.initials: Y
authors.lastname: Takami
authors.forename: K
authors.initials: K
authors.lastname: Makinouchi
authors.forename: J
authors.initials: J
authors.lastname: Gay
authors.forename: D
authors.initials: D
authors.lastname: Taylor
authors.forename: K
authors.initials: K
authors.lastname: Ueyama
authors.forename: Y
authors.initials: Y
authors.lastname: Ohashi
authors.forename: K
authors.initials: K
authors.lastname: Kawahito
authors.forename: E
authors.initials: E
authors.lastname: Tayama
authors.forename: J
authors.initials: J
authors.lastname: Glueck
authors.forename: Y
authors.initials: Y
authors.lastname: Nosé
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000704:Analysis of Variance; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001806:Blood Urea Nitrogen; D002315:Cardiopulmonary Bypass / Q000295:instrumentation*; D002417:Cattle; D003404:Creatinine / Q000097:blood; D006353:Heart-Assist Devices / Q000592:standards*; D006400:Hematocrit; D006439:Hemodynamics; D006454:Hemoglobins / Q000378:metabolism; D006461:Hemolysis; D007770:L-Lactate Dehydrogenase / Q000097:blood; D010107:Oxygenators, Membrane / Q000592:standards; D011786:Quality Control; D013927:Thrombosis / Q000517:prevention & control
chemical_list: D006454:Hemoglobins; D003404:Creatinine; D007770:L-Lactate Dehydrogenase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase