[Bile secretion and the nuclear transcriptional activity of rat liver cells under the action of bile acids].
The intensity of rat's bile secretion under the intraportal infusion of cholic and taurocholic acids has been studied. The results demonstrate that bile acids decrease bile secretion rate under the infusion of these acids in the physiological saline, and increase bile secretion rate under the infusion in saline, with hydrocarbonic ions. Previous treatment by the transcriptional inhibitor actynomycin D affected the development of the hypercholeretic action of the taurocholic acid. The transcriptional activity of the isolated nuclei of liver cells is increased under taurocholic acid action, and decreased under the cholic acid action. The results show that choleretic effects of the bile acids is realised, at least, partially, on the level of the regulatory molecular mechanisms of the cell, the transcription among them.
Masiuk
A I
AI
Kapralov
O O
OO
Dolhova
O M
OM
D000818:Animals; D001646:Bile / Q000187:drug effects* / Q000378:metabolism*; D001647:Bile Acids and Salts / Q000494:pharmacology*; D002467:Cell Nucleus / Q000187:drug effects* / Q000378:metabolism*; D002756:Cholagogues and Choleretics / Q000494:pharmacology*; D003609:Dactinomycin / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D008099:Liver / Q000187:drug effects* / Q000378:metabolism*; D008297:Male; D011500:Protein Synthesis Inhibitors / Q000494:pharmacology; D051381:Rats; D012636:Secretory Rate / Q000187:drug effects; D015533:Transcriptional Activation / Q000187:drug effects*
D001647:Bile Acids and Salts; D002756:Cholagogues and Choleretics; D011500:Protein Synthesis Inhibitors; D003609:Dactinomycin