title: [Long-term prognosis in febrile convulsions with and without prophylaxis].
abstract: This is a long-term follow-up of occurrence of epilepsy, neurological, motor, intellectual, cognitive, and scholastic achievements in a cohort of children with febrile convulsions (n = 289), randomized in early childhood to either intermittent prophylaxis (diazepam at fever) or no prophylaxis (diazepam at seizures). At follow-up the two groups were of almost identical age (14.0 vs. 14.1 years), body weight (58.2 vs. 57.2 kg), height (168.2 vs. 167.7 cm) and head circumference (55.9 vs. 56.2 cm). The neurological examination, fine and gross motor development on Stott motor test, intellectual performance on the Wechsler Intelligence Scale for Children verbal IQ (105 vs. 105), performance IQ (114 vs. 111) and full scale IQ (110 vs. 108). cognitive abilities on an neuropsychological test battery, including short and long term, auditory and visual memory, visuomotor tempo, computer reaction time, reading test, scholastic achievements and the occurrence of subsequent epilepsy were also very similar. Children with simple and complex febrile convulsions had the same benign outcome. The long term prognosis in terms of subsequent epilepsy, neurological, motor, intellectual, cognitive, and scholastic ability was not influenced by the type of treatment applied in early childhood. Preventing new febrile convulsions appears no better in the long run than abbreviating them.
authors.affiliation: Amtssygehuset i Glostrup, børneafdelingen.
authors.forename: F U
authors.initials: FU
authors.lastname: Knudsen
authors.forename: A
authors.initials: A
authors.lastname: Paerregaard
authors.forename: R
authors.initials: R
authors.lastname: Andersen
authors.forename: J
authors.initials: J
authors.lastname: Andresen
mesh_terms: D000927:Anticonvulsants / Q000008:administration & dosage; D002648:Child; D002675:Child, Preschool; D003975:Diazepam / Q000008:administration & dosage; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D009043:Motor Activity; D009460:Neurologic Examination; D011379:Prognosis; D003294:Seizures, Febrile / Q000175:diagnosis / Q000188:drug therapy / Q000517:prevention & control
chemical_list: D000927:Anticonvulsants; D003975:Diazepam