Light and electron microscopic examination of various doses of given vitamin A on the development of cornea in mice. Partly presented in ICEM 13-Paris.
Vitamin A (0.2 micrograms, 0.6 micrograms, 1.2 micrograms) was administered orally to the mice on days 8-11 of gestation. Fetuses were removed on day 17 of gestation. No external malformation of the fetuses was seen on the stereomicroscope investigation. Corneal degeneration was seen on the light and electron microscopic examination. As a result it was accepted that vitamin A taken during the critical periods of gestation affected the development of cornea.
Erdoğan
D
D
Department of Histology-Embryology, Gazi University, Besevler-Ankara, Turkey.
Karabay
G
G
D000284:Administration, Oral; D000818:Animals; D003315:Cornea / Q000187:drug effects / Q000196:embryology* / Q000648:ultrastructure; D004305:Dose-Response Relationship, Drug; D005314:Embryonic and Fetal Development / Q000187:drug effects* / Q000502:physiology; D004727:Endothelium / Q000166:cytology / Q000648:ultrastructure; D005260:Female; D051379:Mice; D008807:Mice, Inbred BALB C / Q000196:embryology* / Q000502:physiology; D008854:Microscopy, Electron / Q000379:methods / Q000662:veterinary; D011247:Pregnancy; D014801:Vitamin A / Q000008:administration & dosage / Q000494:pharmacology*
D014801:Vitamin A