[Pathomechanism of HTLV-I associated arthropathy and the role of tax gene].
HTLV-I is known to be a causative agent for adult T cell leukemia. Recent studies revealed this virus is also related to several autoimmune disorders, such as arthropathy, myelopathy and Sjögren's syndrome. We studied etiology of HTLV-I associated arthropathy (HAAP), and found that tax is a causative gene for synovial proliferation and induction of immunogenicity. HTLV-I transgenic mice supported the etiopathological role of tax gene. Our results suggested that HAAP is considered to be a prototype of rheumatoid arthritis, and tax is a best tool for recognizing pathomechanism of rheumatoid arthritis.
Hasunuma
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Institute of Medical Science, St. Marianna University School of Medicine.
D000818:Animals; D017209:Apoptosis; D001168:Arthritis / Q000209:etiology / Q000821:virology*; D004195:Disease Models, Animal; D016355:Genes, pX / Q000502:physiology*; D015490:HTLV-I Infections; D015368:Human T-lymphotropic virus 1 / Q000235:genetics; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic; D013601:T-Lymphocytes / Q000276:immunology; D019014:fas Receptor
D019014:fas Receptor