title: Immunohistochemical analysis of glutathione S-transferase mu expression in ovarian tumors.
abstract: OBJECTIVE
  To explore the association between Glutathione S-transferase (GST) -mu expression and clinicopathologic features in ovarian tumors.
  
  
  METHODS
  Immunohistochemical study was made to investigate GST-mu expression in diverse ovarian tumors.
  
  
  RESULTS
  All 75 ovarian tumors expressed GST-mu. There was no significant association between GST-mu immunopositivity and clinicopathological features. In serous cystadenocarcinoma, however, patients with weak GST-mu expression survived longer than those with moderate or strong GST-mu expression. Three of the 8 tumors that had expressed weak GST-mu initially increased GST-mu expression after chemotherapy.
  
  
  CONCLUSIONS
  GST-mu expression is common in ovarian tumors and malignant tumors expressed more GST-mu than benign tumors. GST-mu might play a major role in the development of drug resistance in certain ovarian tumors and could be a useful marker of natural resistance and their future outcome.
authors.affiliation: Department of Obstetrics and Gynecology, Okayama University Medical School, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Matsumoto
authors.forename: R
authors.initials: R
authors.lastname: Hayase
authors.forename: J
authors.initials: J
authors.lastname: Kodama
authors.forename: S
authors.initials: S
authors.lastname: Kamimura
authors.forename: M
authors.initials: M
authors.lastname: Yoshinouchi
authors.forename: T
authors.initials: T
authors.lastname: Kudo
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002945:Cisplatin / Q000008:administration & dosage; D005260:Female; D005982:Glutathione Transferase / Q000032:analysis*; D006801:Humans; D007150:Immunohistochemistry; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000201:enzymology
chemical_list: D005982:Glutathione Transferase; D002945:Cisplatin