title: Effect of delmopinol hydrochloride mouthrinse on plaque formation and gingivitis in "rapid" and "slow" plaque formers.
abstract: The aim of the present study was to investigate differences in the plaque and gingivitis inhibiting effect of delmopinol rinsing between "rapid" and "slow" plaque formers. 23 subjects (12 "rapid" and 11 "slow" plaque formers) were selected from 71 healthy young adults. The selection was based on the plaque index on the buccal surfaces of all premolars and 1st molars after 3-days without plaque control. The 23 subjects were randomly assigned into 3 groups with different mouthrinses, i.e., 0.1% delmopinol, 0.2% delmopinol, and placebo. The study was double-blind with parallel design between the "rapid" and "slow" plaque formers and cross-over design between 2 active periods and a placebo period. Each rinsing period lasted for 5 days. During the 3 test periods, the subjects refrained from all oral hygiene and rinsed 2x daily with either one of the 3 solutions. Gingival crevicular fluid (GCF) was collected from buccal surfaces of upper canines and premolars and bleeding on probing (BOP) recorded at 6 sites around each tooth before and after each test period. Plaque assessment, including plaque index (PI) and standardized color slides for planimetric analyses obtained from the canines and premolars, were only recorded after each test period. Results showed that the mean PI and planimetry values for both the "rapid" and "slow" plaque formers were lower than the placebo, for either the 0.1% or the 0.2% delmopinol mouthrinse. The differences between the" rapid" and "slow" plaque formers were not statistically significant. There was a small reduction in BOP in both groups for the delmopinol periods, as against a slight increase in the placebo period; the difference between the placebo group and the 2 groups of plaque formers was not statistically significant (p>0.6 for both 0.1% and 0.2% delmopinol). Results suggested that both 0.1% and 0.2% delmopinol reduce plaque formation and gingivitis to a similar extent in subjects with extreme rates of plaque formation.
authors.affiliation: Department of Periodontology & Public Health, Faculty of Dentistry, The University of Hong Kong.
authors.forename: K
authors.initials: K
authors.lastname: Zee
authors.forename: J
authors.initials: J
authors.lastname: Rundegren
authors.forename: R
authors.initials: R
authors.lastname: Attström
mesh_terms: D000328:Adult; D018592:Cross-Over Studies; D003773:Dental Plaque / Q000473:pathology / Q000517:prevention & control*; D003774:Dental Plaque Index; D004311:Double-Blind Method; D005891:Gingivitis / Q000517:prevention & control*; D006801:Humans; D009025:Morpholines / Q000008:administration & dosage / Q000627:therapeutic use*; D009067:Mouthwashes / Q000627:therapeutic use*; D010512:Periodontal Index; D018709:Statistics, Nonparametric; D013501:Surface-Active Agents / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D009025:Morpholines; D009067:Mouthwashes; D013501:Surface-Active Agents; C073738:delmopinol