title: Drosophila Jun relays the Jun amino-terminal kinase signal transduction pathway to the Decapentaplegic signal transduction pathway in regulating epithelial cell sheet movement.
abstract: We have characterized mutations in the Drosophila homolog of the mammalian proto-oncogene c-Jun gene (Djun). We demonstrate that DJUN in the embryo is a downstream target of the JNK signal transduction pathway during dorsal closure formation, and that the function of the JNK/DJUN pathway is to control the localized expression of decapentalegic (dpp), a member of the TGF-beta growth factor family. In contrast to previous observations, we find that both in the embryo and during photoreceptor cell determination, DJUN is not regulated by a pathway that involves MAPK.
authors.affiliation: Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.
authors.forename: X S
authors.initials: XS
authors.lastname: Hou
authors.forename: E S
authors.initials: ES
authors.lastname: Goldstein
authors.forename: N
authors.initials: N
authors.lastname: Perrimon
mesh_terms: D000818:Animals; D017871:Calcium-Calmodulin-Dependent Protein Kinases / Q000235:genetics / Q000378:metabolism*; D002454:Cell Differentiation; D004330:Drosophila / Q000196:embryology* / Q000235:genetics; D029721:Drosophila Proteins; D004847:Epithelial Cells; D005136:Eye Proteins / Q000235:genetics; D018507:Gene Expression Regulation, Developmental; D017344:Genes, Insect; D019476:Insect Proteins / Q000235:genetics*; D048031:JNK Mitogen-Activated Protein Kinases; D008562:Membrane Glycoproteins / Q000235:genetics; D020928:Mitogen-Activated Protein Kinases; D009154:Mutation; D017956:Photoreceptor Cells, Invertebrate / Q000196:embryology; D016755:Proto-Oncogene Proteins c-jun / Q000378:metabolism*; D020794:Receptor Protein-Tyrosine Kinases; D015398:Signal Transduction
chemical_list: D029721:Drosophila Proteins; D005136:Eye Proteins; D019476:Insect Proteins; D008562:Membrane Glycoproteins; D016755:Proto-Oncogene Proteins c-jun; C064196:dpp protein, Drosophila; D020794:Receptor Protein-Tyrosine Kinases; C056737:sev protein, Drosophila; D017871:Calcium-Calmodulin-Dependent Protein Kinases; D048031:JNK Mitogen-Activated Protein Kinases; D020928:Mitogen-Activated Protein Kinases