Human papillomaviruses are not associated with renal carcinoma.
In an attempt to better understand the troubling issue of renal human papillomavirus (HPV) infection, fresh tumour specimens obtained by surgical extirpation from tumours were compared for the presence of HPV. All of the renal carcinoma samples were examined by PCR using two sets of consensus primers and the specific primer pairs for HPV 16, 18, and 33. None of the 28 carcinomas and 17 corresponding normal tissues were found positive for HPV DNA in any of the applied analyses. Our results suggest that HPV does not play any role in the development of renal carcinoma in the general population.
Grce
M
M
Division of Molecular Medicine, Ruder Bosković Institute, Zagreb, Croatia.
Furcić
I
I
Hrasćan
R
R
Husnjak
K
K
Krhen
I
I
Mareković
Z
Z
Zeljko
Z
Z
Pavelić
K
K
D002292:Carcinoma, Renal Cell / Q000473:pathology* / Q000601:surgery / Q000821:virology; D017931:DNA Primers; D004273:DNA, Neoplasm / Q000032:analysis; D004279:DNA, Viral / Q000032:analysis; D006801:Humans; D007680:Kidney Neoplasms / Q000473:pathology* / Q000601:surgery / Q000821:virology; D009367:Neoplasm Staging; D027383:Papillomaviridae / Q000302:isolation & purification*; D016133:Polymerase Chain Reaction
D017931:DNA Primers; D004273:DNA, Neoplasm; D004279:DNA, Viral