Effect of glimepiride and glibenclamide, inhibitors of ATP-dependent K(+)-channel, on ischaemia-reperfusion induced arrhythmias in rats.
Glibenclamide or glimepiride pretreatment (5 mg/kg i.p. 30 min prior to coronary ligation) significantly improved the survival rate during reperfusion after 6 min myocardial ischaemia in rats (82% or 67% vs. 17% in controls). Smaller dose of glibenclamide (0.01 mg/kg) did not influence the survival rate (31%), while glimepiride still offered a significant protection (61%). These results suggest that different KATP inhibitors may increase the chance to survive life-threatening arrhythmias during myocardial ischaemia-reperfusion.
Bozdogan
O
O
Department of Pharmacology, Albert Szent-Györgyi Medical University, Szeged, Hungary.
Leprán
I
I
Papp
J G
JG
D000255:Adenosine Triphosphate / Q000502:physiology*; D000818:Animals; D001145:Arrhythmias, Cardiac / Q000209:etiology* / Q000401:mortality / Q000503:physiopathology; D004305:Dose-Response Relationship, Drug; D005905:Glyburide / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects; D008297:Male; D017202:Myocardial Ischemia / Q000150:complications*; D015428:Myocardial Reperfusion Injury / Q000150:complications*; D026902:Potassium Channel Blockers; D051381:Rats; D017207:Rats, Sprague-Dawley; D013453:Sulfonylurea Compounds / Q000494:pharmacology*; D016019:Survival Analysis
D026902:Potassium Channel Blockers; D013453:Sulfonylurea Compounds; C057619:glimepiride; D000255:Adenosine Triphosphate; D005905:Glyburide