[Relationship between cellular DNA and expression of epidermal growth factor receptor in pleomorphic adenoma of lacrimal gland].
OBJECTIVE
To obtain the information about whether expression of epidermal growth factor (EGF) receptor is related to the proliferative activity of tumor.


METHODS
The expression of EGF receptor and DNA content of pleomorphic adenoma of lacrimal gland in 32 cases were detected by an immunohistochemical avidin biotin peroxidase complex method and determined by an image analysis technique, respectively. The relationship between the expression of EGF receptor and DNA content was analyzed.


RESULTS
10 tumors were stained positively with anti-EGF receptor antibody, the DNA contents of 14 cases were increased, their DNA ploidy distribution pattern showed two or several peaks. Good correlation has been found between the expression of EGF receptor and DNA ploidy distribution pattern, and the DNA distribution pattern of tumor with positive EGF receptor expression showed mainly two or several peaks (P < 0.01).


CONCLUSIONS
The expression of EGF receptor of pleomorphic tumor of lacrimal gland is related to the proliferative activity of tumor cells.
Zheng
L
L
Ophthalmology Department, First Affiliated Hospital, Second Military Medical University, Shanghai.
He
S
S
Fan
Z
Z
D008949:Adenoma, Pleomorphic / Q000235:genetics / Q000378:metabolism*; D000782:Aneuploidy; D004273:DNA, Neoplasm / Q000235:genetics / Q000378:metabolism*; D066246:ErbB Receptors / Q000378:metabolism*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007150:Immunohistochemistry; D007766:Lacrimal Apparatus Diseases / Q000235:genetics / Q000378:metabolism*
D004273:DNA, Neoplasm; D066246:ErbB Receptors