Clonal chromosome aberrations in three of five sporadic angiomyolipomas of the kidney.
Clonal chromosomal changes were detected in three of five sporadic angiomyolipomas of the kidney irrespective of a solitary or multifocal appearance of this benign tumor type. No specific chromosomal changes have been identified. Including the cytogenetic data of the four renal angiomyolipomas reported in the literature, trisomy 7 as the single clonal chromosomal abnormality was detected in two angiomyolipomas. Because trisomy 7 has been reported in both neoplastic and nonneoplastic kidney cells, it may be assumed that trisomy 7 is already physiologically resident in renal cells but undergoes positive selection in this tumor type.
Wullich
B
B
Clinic of Urology and Pediatric Urology, University of the Saarland, Homburg/Saar, Germany.
Henn
W
W
Siemer
S
S
Seitz
G
G
Freiler
A
A
Zang
K D
KD
D000328:Adult; D018207:Angiomyolipoma / Q000235:genetics* / Q000473:pathology; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D007680:Kidney Neoplasms / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged