[The role of the thrombocytic cationic protein (beta-lysin) in anti-infectious protection].
The biological activity of beta-lysin, cationite protein of thrombocytic origin with bactericidal activity, isolated from human blood serum was studied. The mechanisms of its bactericidal action was determined: the inhibition of bacterial catalase and peroxidase. The study revealed that the activity of beta-lysin in anti-infectious protection was due to both its direct bactericidal action and the enhancement the phagocytic reaction of the body by the stimulation of phagocytes and the opsonization of the pathogen.
Bukharin
O V
OV
Suleĭmanov
K G
KG
D000818:Animals; D023181:Antimicrobial Cationic Peptides; D001770:Blood Bactericidal Activity; D001792:Blood Platelets / Q000276:immunology*; D001798:Blood Proteins; D004353:Drug Evaluation, Preclinical; D005260:Female; D006801:Humans; D008297:Male; D051379:Mice; D008970:Molecular Weight; D010587:Phagocytosis; D011506:Proteins / Q000008:administration & dosage / Q000276:immunology* / Q000302:isolation & purification; D011552:Pseudomonas Infections / Q000517:prevention & control*; D012481:Salmonella Infections, Animal / Q000517:prevention & control*; D012486:Salmonella typhimurium
D023181:Antimicrobial Cationic Peptides; D001798:Blood Proteins; D011506:Proteins; C011679:beta lysin, human; C475592:beta lysin, mouse