Antimicrobial and cytotoxic phenolic glycoside esters from the New Zealand tree Toronia toru.
Two new compounds, 4-hydroxyphenyl 6-O-(4-hydroxy-2-methylenebutanoyl)-beta-D-glycopyranoside (1) and 4-hydroxyphenyl 6-O-[(3R)-3,4-dihydroxy-2-methylenebutanoyl]-beta-D-glucopyranosid e (2), have been isolated from foliage of Toronia toru. Compound 2 was the main antimicrobial component (7 mg/g of dry foliage) of the crude extract and also showed significant cytotoxic activity against P-388 leukemia cells.
Perry
N B
NB
Plant Extracts Research Unit, New Zealand Institute for Crop & Food Research Limited, Dunedin, New Zealand. perryn@alkali.otago.ac.nz
Brennan
N J
NJ
D000890:Anti-Infective Agents / Q000302:isolation & purification* / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006027:Glycosides / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D009520:New Zealand; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013056:Spectrophotometry, Ultraviolet
C107778:4-hydroxyphenyl-6-O-(3,4-dihydroxy-2-methylenebutanoyl)glucopyranoside; C107777:4-hydroxyphenyl-6-O-(4-hydroxy-2-methylenebutanoyl)glucopyranoside; D000890:Anti-Infective Agents; D000972:Antineoplastic Agents, Phytogenic; D006027:Glycosides