title: Second primary cancer due to radiotherapy and chemotherapy.
abstract: Cancer patients are treated successfully with chemotherapy, radiotherapy, or a combination of both. However, many agents used in cancer chemotherapy as well as ionizing radiation are known carcinogens. The long survival of cancer patients treated successfully for their primary cancer made possible the observations of late effects of radiotherapy and chemotherapy and, in particular, the occurrence of second primary cancers. In this report we review the cases of five patients with second primary malignancies and wish to emphasize the importance of a thorough follow-up of patients treated successfully for and possibly cured of a primary cancer.
authors.affiliation: Department of Medical Oncology, Uludağ University School of Medicine, Bursa, Turkey.
authors.forename: O
authors.initials: O
authors.lastname: Manavoğlu
authors.forename: B
authors.initials: B
authors.lastname: Orhan
authors.forename: T
authors.initials: T
authors.lastname: Evrensel
authors.forename: Y
authors.initials: Y
authors.lastname: Karabulut
authors.forename: V
authors.initials: V
authors.lastname: Ozkocaman
authors.forename: C
authors.initials: C
authors.lastname: Ozyardimci
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000532:radiotherapy; D003110:Colonic Neoplasms / Q000188:drug therapy; D064420:Drug-Related Side Effects and Adverse Reactions; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy / Q000532:radiotherapy; D008223:Lymphoma / Q000188:drug therapy / Q000532:radiotherapy; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000188:drug therapy; D009381:Neoplasms, Radiation-Induced / Q000473:pathology*; D016609:Neoplasms, Second Primary / Q000139:chemically induced* / Q000209:etiology*; D011878:Radiotherapy / Q000009:adverse effects*