title: Recovery of taste aversion learning induced by fetal neocortex grafts: correlation with in vivo extracellular acetylcholine.
abstract: Rats showing disrupted taste aversion due to insular cortex lesions, received either homotopic or heterotopic (occipital) cortical fetal brain grafts. Behavioral results showed that the recovery of the ability to acquire conditioned taste aversions induced by fetal grafts depended on post-graft time (45 but not at 15 days) and tissue specificity (homotopic but not heterotopic). In vivo analysis of acetylcholine (ACh) release revealed that only the group receiving homotopic grafts and tested 45 days post graft had a release of ACh after KCl stimulation similar to that in the control group. Furthermore, homotopic grafts and lesioned groups showed significantly weaker specific receptor binding of [3H]L-glutamate compared with controls. These results suggest that ACh is specifically involved in the process of behavioral recovery induced by homotopic cortical transplants.
authors.affiliation: Departamento de Neurociencias, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, D.F.
authors.forename: M I
authors.initials: MI
authors.lastname: Miranda
authors.forename: A M
authors.initials: AM
authors.lastname: Löpez-Colomé
authors.forename: F
authors.initials: F
authors.lastname: Bermúdez-Rattoni
mesh_terms: D000109:Acetylcholine / Q000378:metabolism; D000818:Animals; D001362:Avoidance Learning / Q000502:physiology*; D002540:Cerebral Cortex / Q000196:embryology* / Q000378:metabolism / Q000502:physiology*; D003213:Conditioning, Psychological / Q000502:physiology; D005110:Extracellular Space / Q000378:metabolism; D016332:Fetal Tissue Transplantation; D018698:Glutamic Acid / Q000378:metabolism; D008297:Male; D017551:Microdialysis; D011189:Potassium Chloride / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013649:Taste / Q000502:physiology*; D016042:Transplantation, Heterotopic
chemical_list: D018698:Glutamic Acid; D011189:Potassium Chloride; D000109:Acetylcholine