title: Normal recovery of the stratum corneum barrier function following damage induced by tape stripping in patients with atopic dermatitis.
abstract: Patients with atopic dermatitis (AD) constantly inflict mechanical damage to their skin by scratching induced by pruritus. On excoriated lesions of the cheek we found exceedingly high levels of transepidermal water loss (TEWL) as compared to those in the normal skin of healthy subjects. However, it is not clear whether the skin of patients with AD also shows an abnormally slow recovery after mechanical damage. We compared the recovery of the barrier function of the stratum corneum (SC), after its complete removal by tape stripping, in patients with AD and age-matched healthy control subjects. On the normal-looking skin of the flexor forearm, we found no difference in the recovery process of the water barrier function of the SC between the two groups. This suggests that ability to reconstruct SC barrier function after mechanical damage is not impaired in AD patients.
authors.affiliation: Department of Dermatology, Tohoku University School of Medicine, Sendai, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Tanaka
authors.forename: Y X
authors.initials: YX
authors.lastname: Zhen
authors.forename: H
authors.initials: H
authors.lastname: Tagami
mesh_terms: D000328:Adult; D002463:Cell Membrane Permeability; D003876:Dermatitis, Atopic / Q000503:physiopathology*; D004817:Epidermis / Q000293:injuries* / Q000503:physiopathology*; D005145:Face; D005260:Female; D006801:Humans; D008297:Male; D014870:Water Loss, Insensible; D014945:Wound Healing