Electrically-assisted transdermal drug delivery.
Electrically-assisted transdermal delivery (EATDD) is the facilitated transport of compounds across the skin using an electromotive force. It has been extensively explored as a potential means for delivering peptides and other hydrophilic, acid-labile or orally unstable products of biotechnology. The predominant mechanism for delivery is iontophoresis, although electroosmosis and electroporation have also been investigated. The focus of this review is to put these different mechanisms in perspective and relate them to the drug and skin model system being investigated.
Riviere
J E
JE
Cutaneous Pharmacology and Toxicology Center, North Carolina State University, Raleigh 27606, USA. Jim_Riviere@ncsu.edu
Heit
M C
MC
D000279:Administration, Cutaneous; D000818:Animals; D016503:Drug Delivery Systems; D018274:Electroporation; D006801:Humans; D007478:Iontophoresis; D009995:Osmosis; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D012867:Skin / Q000378:metabolism; D012869:Skin Absorption
D004364:Pharmaceutical Preparations