[A study on changes of levels of products of lipid peroxidation in retina of rat with experimental autoimmune uveoretinitis].
OBJECTIVE
To understand the mechanisms of the retinal tissue destruction of rat with experimental autommune uveoretinitis (EAU) induced by rabbit retinal soluble antigen.


METHODS
The levels of the following products of lipid peroxidation were determined at different times, conjugated dienes, malondialdehyde, fluorochrome lipid and lipid hydrogen peroxide.


RESULTS
In the process of EAU, the levels of products of lipid peroxidation in the retina were increased gradually in various degrees.


CONCLUSIONS
It is suggested that the damage from lipid peroxidation mediated by free radicals of the retina be one of the factors which induces the retinal destruction in EAU.
Sun
X
X
Beijing Institute of Ophthalmology.
Zhang
C
C
D000818:Animals; D019393:Arrestin; D001327:Autoimmune Diseases / Q000139:chemically induced / Q000378:metabolism*; D005609:Free Radicals; D015227:Lipid Peroxidation; D008054:Lipid Peroxides / Q000378:metabolism*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012160:Retina / Q000378:metabolism*; D012173:Retinitis / Q000139:chemically induced / Q000378:metabolism*; D014605:Uveitis / Q000139:chemically induced / Q000378:metabolism*
D019393:Arrestin; D005609:Free Radicals; D008054:Lipid Peroxides; D008315:Malondialdehyde