Bilateral peripheral ulcerative keratitis associated with pyoderma gangrenosum.
OBJECTIVE
A 37-year-old Hispanic man with a history of chronic myelogenous leukemia was first seen with fever and preseptal cellulitis of this right orbit after a tooth extraction.


METHODS
The patient subsequently developed bilateral, severe peripheral ulcerative keratitis. He was treated with systemic antibiotics for a presumed underlying infectious cause. Several painful, necrotizing skin lesions developed over his face, trunk, and extremities.


RESULTS
Repeated skin biopsies of the necrotizing lesions were consistent with pyoderma gangrenosum. Both the skin lesions and peripheral ulcerative keratitis responded dramatically to systemic prednisone.


CONCLUSIONS
Pyoderma gangrenosum should be included in the differential diagnosis of peripheral ulcerative keratitis.
Bouchard
C S
CS
Department of Ophthalmology, Loyola University Medical Center, Chicago, Illinois 60153, USA.
Meyer
M A
MA
McDonnell
J F
JF
D000328:Adult; D001706:Biopsy; D003315:Cornea / Q000473:pathology; D003320:Corneal Ulcer / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D003937:Diagnosis, Differential; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000150:complications; D008297:Male; D011241:Prednisone / Q000627:therapeutic use; D017511:Pyoderma Gangrenosum / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D012867:Skin / Q000473:pathology; D014792:Visual Acuity
D005938:Glucocorticoids; D011241:Prednisone