title: Classification system of complications in neuroleptic malignant syndrome.
abstract: Our group treated 13 cases of neuroleptic malignant syndrome (NMS) over a period of 8 years. Based on the clinical severity of complications, the cases were classified into three types: mild, with no complications; moderate, with only respiratory disturbance; and severe, with respiratory disturbance and renal failure. The major complications affecting the prognosis of NMS are respiratory disturbance and renal failure. Renal failure is also associated with the occurrence of disseminated intravascular coagulation and rhabdomyolysis. The proposed classification system for NMS patients is useful in selecting the appropriate therapeutic strategy for this disorder. The clinical data were analyzed to determine the factors in the process of deterioration in NMS.
authors.affiliation: Department of Neuropsychiatry, Osaka University Medical School, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Taniguchi
authors.forename: H
authors.initials: H
authors.lastname: Tanii
authors.forename: T
authors.initials: T
authors.lastname: Nishikawa
authors.forename: Y
authors.initials: Y
authors.lastname: Miyamae
authors.forename: K
authors.initials: K
authors.lastname: Shinozaki
authors.forename: Y
authors.initials: Y
authors.lastname: Inoue
authors.forename: T
authors.initials: T
authors.lastname: Morihara
authors.forename: Y
authors.initials: Y
authors.lastname: Nakano
authors.forename: T
authors.initials: T
authors.lastname: Nishimura
authors.forename: M
authors.initials: M
authors.lastname: Takeda
mesh_terms: D000293:Adolescent; D000328:Adult; D001706:Biopsy; D003402:Creatine Kinase / Q000097:blood; D004211:Disseminated Intravascular Coagulation / Q000097:blood / Q000209:etiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009459:Neuroleptic Malignant Syndrome / Q000097:blood / Q000145:classification* / Q000150:complications; D051437:Renal Insufficiency / Q000097:blood / Q000209:etiology; D012120:Respiration Disorders / Q000097:blood / Q000209:etiology; D012206:Rhabdomyolysis / Q000097:blood / Q000209:etiology / Q000473:pathology; D012720:Severity of Illness Index
chemical_list: D003402:Creatine Kinase