[The pharmacokinetics of the dipeptide analog of piracetam with nootropic activity GVS-111 and of its basic metabolites].
The pharmacokinetics of a new nootropic dipeptide analog of piracetam-N-phenylacetyl-L-prolylglycine (GWS-111) and its main metabolites were studied in rats by means of high performance liquid chromatography and gas-liquid chromatography. The compound under study showed a greater resistance to an enzymatic effect than natural neuropeptides. In addition to an unchanged compound three of its metabolites were found in the blood plasma of the rats. One of them, cyclo-Pro-Gly was an active metabolite of GWS-111.
Boĭko
S S
SS
Zherdev
V P
VP
Dvorianinov
A A
AA
Gudasheva
T A
TA
Ostrovskaia
R U
RU
Voronina
T A
TA
Rozantsev
G G
GG
Seredenin
S B
SB
D000818:Animals; D002849:Chromatography, Gas; D002851:Chromatography, High Pressure Liquid; D004151:Dipeptides / Q000097:blood / Q000493:pharmacokinetics*; D008297:Male; D018697:Nootropic Agents / Q000097:blood / Q000493:pharmacokinetics*; D010889:Piracetam / Q000031:analogs & derivatives*; D051381:Rats; D013997:Time Factors
D004151:Dipeptides; D018697:Nootropic Agents; C103871:ethyl phenylacetyl-Pro-Gly; D010889:Piracetam