title: Small cell carcinoma of the ovary, hypercalcemic type. A case report with immunohistochemical, ultrastructural and cytophotometric analysis and review of the literature.
abstract: Small cell carcinomas of the ovary, hypercalcemic type, are unilateral tumors occurring almost exclusively in young women. 60% of the cases are associated with hypercalcemia. Microscopic examination shows diffuse clusters of small cells and follicle-like spaces. Immunohistochemically, the tumor cells are positive for epithelial and mesenchymal markers, and ultrastructurally they contain an abundance of dilated rough endoplasmatic reticulum and numerous free ribosomes. By DNA-single cell photometry, the neoplastic cells show a diploid DNA-content.
authors.affiliation: Department of Pathology, Hospital Nordstadt, Hanover, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Förster
authors.forename: H
authors.initials: H
authors.lastname: Ostertag
authors.forename: J
authors.initials: J
authors.lastname: Schmitt
authors.forename: A
authors.initials: A
authors.lastname: Roessner
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000032:analysis; D018288:Carcinoma, Small Cell / Q000737:chemistry / Q000473:pathology* / Q000601:surgery / Q000648:ultrastructure; D005260:Female; D006801:Humans; D006934:Hypercalcemia / Q000175:diagnosis*; D007150:Immunohistochemistry; D008854:Microscopy, Electron; D010051:Ovarian Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery / Q000648:ultrastructure; D011003:Ploidies
chemical_list: D015415:Biomarkers