[How can we monitor and treat patients with acute exacerbations of idiopathic interstitial pneumonia].
Levels of KL-6 in serum were measured in 17 patients during acute exacerbations of idiopathic interstitial pneumonia (IIP). The patients were divided into three groups: "effectively" treated (n = 4), "ineffectively" treated (n = 4), and "untreated" with steroid pulse therapy (n = 9). In the "ineffective" group, the level of KL-6 in serum was significantly higher than that in the "effective" group. These results suggest that KL-6 is useful for assessing patients with acute exacerbations of IIP. In a separate study ONO-5046, a specific neutrophil elastase inhibitor, was given in 40 institutions to find out if it is useful in treating IIP. The PaO2/FIO2 ratio after the administration of ONO-5046 was significantly improved in high-dose group, which suggests that this agent is useful in treating patients with IIP.
Kobayashi
J
J
Department of Pulmonary Medicine, Jichi Medical School, Tochigi, Japan.
Kitamura
S
S
D000210:Acute-Phase Reaction; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage; D000941:Antigens / Q000097:blood*; D000951:Antigens, Neoplasm; D015415:Biomarkers / Q000097:blood; D017322:Clinical Trials, Phase II as Topic; D004359:Drug Therapy, Combination; D005998:Glycine / Q000008:administration & dosage / Q000031:analogs & derivatives; D006023:Glycoproteins / Q000097:blood*; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000175:diagnosis* / Q000188:drug therapy; D008775:Methylprednisolone / Q000008:administration & dosage; D008991:Monitoring, Physiologic; D018396:Mucin-1; D009077:Mucins; D015842:Serine Proteinase Inhibitors / Q000008:administration & dosage; D013449:Sulfonamides / Q000008:administration & dosage
D000893:Anti-Inflammatory Agents; D000941:Antigens; D000951:Antigens, Neoplasm; D015415:Biomarkers; D006023:Glycoproteins; C060192:MUC1 protein, human; D018396:Mucin-1; D009077:Mucins; D015842:Serine Proteinase Inhibitors; D013449:Sulfonamides; C069195:sivelestat; D005998:Glycine; D008775:Methylprednisolone