title: Effects of chronic treatments with adrenal steroids on acid-base homeostasis in the rat.
abstract: Urinary parameters related to acid base homeostasis were studied in adrenalectomized rats (ADX) as well as in ADX treated with physiological doses of corticosterone (B), aldosterone (aldo) or 18-Hydroxycorticosterone (18HOB) during 1, 3 or 5 days, under basal conditions and after gravage with 200 mM HCI. The results showed: a) persistent effect of B and 18HOB increasing titratable acidity principally in response to acidosis; b) an increased phosphate elimination in acidotic B treated ADX on the first day, and in 18 HOB treated ADX on days 3 and 5; c) pronounced increases in blood pH and blood bicarbonate levels provoked by the three steroids on day 1; d) increments of ammonium elimination in response to acidosis by aldo treatments on the first day, while B and 18HOB increase ammonium elimination under almost all conditions during the whole experiment; e) the effects of B and 18 HOB would be independent of an increase in sodium retention as well as glomerular filtration rate.
authors.affiliation: PRHOM CONICET, Depto. de Química Biológica-Facultad de Ciencias Exactas y Naturales, UBA. Cdad. Universitaria, Bs. As.
authors.forename: M P
authors.initials: MP
authors.lastname: Igarreta
authors.forename: C P
authors.initials: CP
authors.lastname: Lantos
authors.forename: M C
authors.initials: MC
authors.lastname: Damasco
mesh_terms: D000136:Acid-Base Equilibrium / Q000187:drug effects*; D000450:Aldosterone / Q000494:pharmacology*; D000818:Animals; D003345:Corticosterone / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects / Q000502:physiology; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000450:Aldosterone; D003345:Corticosterone