The role of oxygen free radicals in idiopathic facial pain.
Patients with chronic facial pain including those with facial arthromyalgia (TMJ dysfunction syndrome) were investigated for evidence of abnormal systemic and intra-articular free radical activity. Chronic facial pain patients showed significantly raised serum 2,3-dihydroxybenzoic acid after an oral dose of 1.2 g of aspirin which indicates increased systemic free radical activity. This was reflected in the TMJ aspirates of the facial arthromyalgia patients which contained thiobarbituric acid-reactive substance (TBA-RS) which is also a product of free radical activity. The synovial aspirates also contained high levels of the hyperalgesic eicosanoid 15-HETE. However, there was no difference between the painful and symptom-free joints, which suggested that in part the clinical features are probably determined by asymmetrical masticatory function or as yet unknown algesic factors such as local cytokine production.
Aghabeigi
B
B
Department of Oral and Maxillofacial Surgery, Eastman Dental and University College London Hospitals, UK.
Haque
M
M
Wasil
M
M
Hodges
S J
SJ
Henderson
B
B
Harris
M
M
D000284:Administration, Oral; D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000493:pharmacokinetics; D001241:Aspirin / Q000008:administration & dosage / Q000493:pharmacokinetics; D016022:Case-Control Studies; D002908:Chronic Disease; D016207:Cytokines / Q000378:metabolism; D015232:Dinoprostone / Q000032:analysis; D005157:Facial Pain / Q000209:etiology* / Q000378:metabolism; D005260:Female; D005609:Free Radicals / Q000378:metabolism / Q000494:pharmacology; D005841:Gentisates; D006801:Humans; D062385:Hydroxybenzoates / Q000097:blood; D006893:Hydroxyeicosatetraenoic Acids / Q000032:analysis; D007502:Iron Chelating Agents / Q000032:analysis; D007975:Leukotriene B4 / Q000032:analysis; D008297:Male; D008409:Mastication; D008875:Middle Aged; D017382:Reactive Oxygen Species / Q000378:metabolism / Q000502:physiology*; D013582:Synovial Fluid / Q000737:chemistry; D013704:Temporomandibular Joint / Q000378:metabolism; D013706:Temporomandibular Joint Dysfunction Syndrome / Q000209:etiology / Q000378:metabolism; D017392:Thiobarbituric Acid Reactive Substances / Q000032:analysis
D000894:Anti-Inflammatory Agents, Non-Steroidal; D016207:Cytokines; D005609:Free Radicals; D005841:Gentisates; D062385:Hydroxybenzoates; D006893:Hydroxyeicosatetraenoic Acids; D007502:Iron Chelating Agents; D017382:Reactive Oxygen Species; D017392:Thiobarbituric Acid Reactive Substances; D007975:Leukotriene B4; C009135:2,3-dihydroxybenzoic acid; C025984:15-hydroxy-5,8,11,13-eicosatetraenoic acid; D015232:Dinoprostone; D001241:Aspirin; C010925:2,5-dihydroxybenzoic acid