[The possibility of using highly disperse iron for the directed transport of thyroxin in the body].
It has been ascertained that high-disperse powders of iron obtained by a thermochemical method in the process of formation of particles with pre-determined physical-and-chemical and medical-and-biological properties (essentially monodisperse, harmless, capable of exerting a bactericidal action, having an as-needed specific surface, corrosion resistance, withstanding sterilization heat up to 120 degrees C, allowing the magnetic characteristics to be controlled, etc.) can be used for directed transport of medicinal substances (thyroxin), hormone control, protection of the organism from overdosing of the administered drug preparations. Feasibility is shown of prolonged administration of thyroid hormones through the gastrointestinal wall with the aid of high-disperse ferromagnetic compositions as containers-carriers, which fact may secure the organism-controlled maintenance of the thyroid status in various thyroidal pathologies.
Shvets
T M
TM
Kushchevskaia
N F
NF
Klochko
E V
EV
D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D002463:Cell Membrane Permeability / Q000187:drug effects; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004337:Drug Carriers; D005290:Ferric Compounds / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics; D007408:Intestinal Absorption / Q000187:drug effects; D007501:Iron / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics*; D011208:Powders; D051381:Rats; D017208:Rats, Wistar; D013974:Thyroxine / Q000008:administration & dosage / Q000493:pharmacokinetics*; D013997:Time Factors; D014284:Triiodothyronine / Q000008:administration & dosage / Q000493:pharmacokinetics
D004337:Drug Carriers; D005290:Ferric Compounds; D011208:Powders; D014284:Triiodothyronine; C001215:ferrite; D007501:Iron; D013974:Thyroxine