title: [Alcohol intake and risk of liver disease--significance of gender. A population study].
abstract: The association between self-reported alcohol intake and the risk of future liver disease was studied in a population-based prospective cohort of 13,285 men and women aged 30-79 years. Diagnoses indicating alcoholic liver disease (n = 261) or cirrhosis (n = 124) were obtained from the Danish National Health Registers. The cumulated observation time was 130,558 person-years. A dose-dependent increase in risk of developing liver disease was observed with increasing alcohol intake, with the steepest increase among women. At an alcohol intake of 7-13 beverages per week for women and 14-27 beverages per week for men the relative risk was significantly greater than 1. Women had a significantly higher relative risk of developing alcohol related liver disease than men for any given level of alcohol intake. In the general population, self-reported current alcohol intake is a good predictor of the future risk of alcoholic liver disease.
authors.affiliation: Kommunehospitalet, Center for Epidemiologisk Grundforskning, Kabenhavn.
authors.forename: P U
authors.initials: PU
authors.lastname: Becker
authors.forename: A
authors.initials: A
authors.lastname: Deis
authors.forename: T I
authors.initials: TI
authors.lastname: Sørensen
authors.forename: M N
authors.initials: MN
authors.lastname: Grønbaek
authors.forename: K
authors.initials: K
authors.lastname: Borch-Johnsen
authors.forename: C F
authors.initials: CF
authors.lastname: Müller
authors.forename: P
authors.initials: P
authors.lastname: Schnohr
authors.forename: G B
authors.initials: GB
authors.lastname: Jensen
mesh_terms: D000328:Adult; D000368:Aged; D000428:Alcohol Drinking / Q000009:adverse effects*; D000437:Alcoholism / Q000150:complications / Q000453:epidemiology; D056486:Chemical and Drug Induced Liver Injury; D005260:Female; D006801:Humans; D008104:Liver Cirrhosis, Alcoholic / Q000453:epidemiology / Q000209:etiology; D008107:Liver Diseases / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D012649:Self Concept; D012737:Sex Factors