title: Identification of novel 'expressed sequence tags' within the FHIT gene locus in human chromosome region 3p14.2.
abstract: Losses of genetic material within human chromosome regions (HCR) 3p12-p14 and 3p21-p22 are observed in various neoplasias, suggesting tumor suppressor gene (TSG) loci within these regions. HCR 3p14 is particularly interesting as it contains the t(3;8) translocation breakpoint of a hereditary renal cell carcinoma, the FRA3B fragile site, and DNA markers deleted in several types of human cancer. We here report on the identification of five novel 'expressed sequence tags' (ESTs) within 3p14.2 which map proximal to exon 9 of the candidate TSG, FHIT. These ESTs may be valuable for elucidation of the supposed TSG content in 3p14.2.
authors.affiliation: Innere Klinik und Poliklinik (Tumorforschung), Universitätsklinikum Essen, Westdeutsches Tumorzentrum, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Lux
authors.forename: W
authors.initials: W
authors.lastname: Bardenheuer
authors.forename: D
authors.initials: D
authors.lastname: Michael
authors.forename: F
authors.initials: F
authors.lastname: Bröcker
authors.forename: K
authors.initials: K
authors.lastname: Jülicher
authors.forename: L
authors.initials: L
authors.lastname: Vieten
authors.forename: S
authors.initials: S
authors.lastname: Michaelis
authors.forename: S
authors.initials: S
authors.lastname: Seeber
authors.forename: B
authors.initials: B
authors.lastname: Opalka
authors.forename: J
authors.initials: J
authors.lastname: Schütte
mesh_terms: D017766:Acid Anhydride Hydrolases; D002460:Cell Line; D002874:Chromosome Mapping; D002893:Chromosomes, Human, Pair 3 / Q000235:genetics*; D003001:Cloning, Molecular; D018076:DNA, Complementary; D015870:Gene Expression; D016147:Genes, Tumor Suppressor; D006801:Humans; D008969:Molecular Sequence Data; D009363:Neoplasm Proteins / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011506:Proteins / Q000235:genetics*; D017422:Sequence Analysis, DNA; D000099170:Bis(5'-adenosyl)triphosphatase
chemical_list: D017766:Acid Anhydride Hydrolases; D018076:DNA, Complementary; D009363:Neoplasm Proteins; D011506:Proteins; D000099170:Bis(5'-adenosyl)triphosphatase