Antihypertensive drugs and fatal myocardial infarction in persons with uncomplicated hypertension.
We conducted a case-control study to evaluate the risk of fatal myocardial infarction in otherwise healthy treated hypertensive subjects according to the type of the antihypertensive drug used. The study encompassed 207 cases and 409 controls matched to cases on age, sex, and general practice. Compared with beta-blocker users, the matched relative risk estimates for fatal myocardial infarction, adjusted for recent blood pressure, body mass index, smoking, duration of hypertension, and prior use of other antihypertensive drugs, were 0.7 [95% confidence interval (CI) = 0.4-1.2] for angiotensin-converting enzyme inhibitor users, 0.9 (95% CI = 0.5-1.5) for calcium channel blocker users, and 0.7 (95% CI = 0.4-1.2) for diuretic users.
Jick
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Boston Collaborative Drug Surveillance Program, Boston University Medical Center, Lexington, MA 02173, USA.
Vasilakis
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C
Derby
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D000319:Adrenergic beta-Antagonists / Q000009:adverse effects; D000368:Aged; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000009:adverse effects; D000959:Antihypertensive Agents / Q000009:adverse effects*; D002121:Calcium Channel Blockers / Q000009:adverse effects; D016022:Case-Control Studies; D002423:Cause of Death; D016001:Confidence Intervals; D016208:Databases, Factual; D004232:Diuretics / Q000009:adverse effects; D005194:Family Practice / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D016015:Logistic Models; D008297:Male; D009203:Myocardial Infarction / Q000401:mortality*; D012306:Risk; D012907:Smoking / Q000009:adverse effects / Q000453:epidemiology; D006113:United Kingdom / Q000453:epidemiology
D000319:Adrenergic beta-Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D002121:Calcium Channel Blockers; D004232:Diuretics