title: Epididymal and sex accessory gland secretions in transfusion-dependent beta-thalassemic patients: evidence of an impaired prostatic function.
abstract: Neutral alpha-glucosidase levels as epididymal marker, fructose levels as vesicular marker, zinc, citric acid and prostate specific antigen levels as prostatic markers were measured in the seminal plasma of eight transfusion-dependent beta-thalassemic patients in order to study epididymal and sex accessory gland secretions (eighteen subjects served as controls). FSH and LH as well as total and free testosterone were detected displaying unaltered serum values. Ejaculate of patients showed normal sperm count and low sperm motility, in the meantime seminal plasma exhibited unaltered both neutral alpha-glucosidase and fructose values but low levels of zinc, citric acid and prostate specific antigen were noticed as well. These data suggest an impaired prostatic secretion in the thalassemic patients studied. A local iron toxicity on the prostatic tissue could be supported by the decrease of its specific markers observed only in the subgroup of patients with high ferritin serum levels.
authors.affiliation: Department of Cellular Biology, University of Calabria, Arcavacata di Rende, Cosenza, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Carpino
authors.forename: V
authors.initials: V
authors.lastname: De Sanctis
authors.forename: L
authors.initials: L
authors.lastname: Siciliano
authors.forename: M
authors.initials: M
authors.lastname: Maggiolini
authors.forename: A
authors.initials: A
authors.lastname: Vivacqua
authors.forename: A
authors.initials: A
authors.lastname: Pinamonti
authors.forename: D
authors.initials: D
authors.lastname: Sisci
authors.forename: S
authors.initials: S
authors.lastname: Andó
mesh_terms: D000293:Adolescent; D000328:Adult; D001803:Blood Transfusion; D004822:Epididymis / Q000378:metabolism*; D005293:Ferritins / Q000097:blood; D005640:Follicle Stimulating Hormone / Q000097:blood; D005837:Genitalia, Male / Q000378:metabolism*; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D011467:Prostate / Q000503:physiopathology*; D012661:Semen / Q000378:metabolism; D013739:Testosterone / Q000097:blood; D017086:beta-Thalassemia / Q000097:blood / Q000503:physiopathology / Q000628:therapy*
chemical_list: D013739:Testosterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D005293:Ferritins