title: Biomaterials for orthopedic surgery in osteoporotic bone: a comparative study in osteopenic rats.
abstract: To evaluate orthopedic devices in pathological bone, an experimental study was performed by implanting Titanium (Ti) and Hydroxyapatite (HA) rods in normal and osteopenic bone. Twenty-four rats were used: 12 were left intact (
  
  
  METHODS
  C) while the other 12 were ovariectomized (OVX). After 4 months all the animals were submitted to the implant of Ti or HA in the left femoral condyle (Ti-C, HA-C, Ti-OVX, HA-OVX). Two months later the animals were sacrificed for histomorphometric, ultrastructural and microanalytic studies. Our results show a significant difference between the Affinity Index (A.I.) of HA-C and Ti-C (77.0 +/- 7.4 vs 61.2 +/- 9.7) (p < 0.05). No significant differences were observed between the osteointegration of Ti-C and Ti-OVX (61.2 +/- 9.7 vs 48.2 +/- 6.7). Significant differences also exist between the osteointegration of HA-C and HA-OVX (77.0 +/- 7.4 vs 57.6 +/- 11.5) (p < 0.01). Microanalysis shows some modifications in Sulphur (S) concentration at the bone/biomaterial interface of the Ti-OVX group. Therefore our results confirmed the importance of biomaterials characteristics and of bone quality in osteointegration processes.
authors.affiliation: Experimental Surgery Department (Rizzoli Orthopaedic Institute), University of Bologna, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Fini
authors.forename: N
authors.initials: N
authors.lastname: Nicoli Aldini
authors.forename: M G
authors.initials: MG
authors.lastname: Gandolfi
authors.forename: M
authors.initials: M
authors.lastname: Mattioli Belmonte
authors.forename: G
authors.initials: G
authors.lastname: Giavaresi
authors.forename: C
authors.initials: C
authors.lastname: Zucchini
authors.forename: A
authors.initials: A
authors.lastname: De Benedittis
authors.forename: S
authors.initials: S
authors.lastname: Amati
authors.forename: A
authors.initials: A
authors.lastname: Ravaglioli
authors.forename: A
authors.initials: A
authors.lastname: Krayewski
authors.forename: M
authors.initials: M
authors.lastname: Rocca
authors.forename: G A
authors.initials: GA
authors.lastname: Guzzardella
authors.forename: G
authors.initials: G
authors.lastname: Biagini
authors.forename: R
authors.initials: R
authors.lastname: Giardino
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D001851:Bone Diseases, Metabolic / Q000473:pathology / Q000601:surgery; D017886:Durapatite; D004578:Electron Spin Resonance Spectroscopy; D005260:Female; D005269:Femur / Q000473:pathology / Q000601:surgery*; D006801:Humans; D008855:Microscopy, Electron, Scanning; D016348:Osseointegration; D015663:Osteoporosis, Postmenopausal / Q000473:pathology / Q000601:surgery*; D010052:Ovariectomy; D019736:Prostheses and Implants; D051381:Rats; D017207:Rats, Sprague-Dawley; D014025:Titanium
chemical_list: D001672:Biocompatible Materials; D017886:Durapatite; D014025:Titanium