Pathogenesis and prevention of HTLV-1-associated diseases.
HTLV-1 is an important factor involved in various diseases including adult T-cell leukemia/lymphoma and HTLV-1 associated myelopathy/tropical spastic paraparesis. Amount of HTLV-1 provirus integrated in human peripheral blood mononuclear cells might be a candidate for a risk factor in the manifestation of HTLV-1 associated diseases. Experimental animal models would be useful to dissect the pathogenesis of HTLV-1 associated diseases. We present rat and mouse models of HTLV-1 infection. Using these animal models, we could clarify the intrauterine transmission of HTLV-1, and have found that both genetic background and HTLV-1 infection are important in pathogenesis of HAM/TSP-like rats. We also discuss the preventive measures of HTLV-1 transmission by use of antisense oligonucleotides.
Miwa
M
M
Department of Biochemistry and Molecular Oncology, University of Tsukuba, Japan.
Kushida
S
S
Maeda
N
N
Fang
J
J
Kawamura
T
T
Kameyama
T
T
Uchida
K
K
D000328:Adult; D000818:Animals; D001782:Blood Donors; D002353:Carrier State; D015490:HTLV-I Infections / Q000453:epidemiology* / Q000517:prevention & control* / Q000635:transmission; D000882:Haplorhini; D015368:Human T-lymphotropic virus 1 / Q000302:isolation & purification*; D006801:Humans; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000453:epidemiology* / Q000517:prevention & control / Q000635:transmission; D051379:Mice; D015493:Paraparesis, Tropical Spastic / Q000453:epidemiology* / Q000517:prevention & control / Q000635:transmission; D011533:Proviruses / Q000302:isolation & purification; D011817:Rabbits; D051381:Rats; D012307:Risk Factors