title: Cutaneous toxicity following the administration of dactinomycin.
abstract: Dactinomycin (AMD) is an effective drug in the management of several malignant disorders and has been used for almost 40 years. Skin and subcutaneous toxicities following extravasation are well known and can be harmful. Similarly radiation-recall is a well established phenomenon following the administration of AMD. We report a patient who developed a localized brawny erythema in the crural folds and the axillae, likely due to AMD. This rare skin complication of AMD seems to benefit from topical corticosteroid treatment, although postinflammatory hyperpigmentation may take months to disappear.
authors.affiliation: Southern Alberta Pediatric Oncology Program, Alberta Children's Hospital, Calgary, Canada.
authors.forename: M J
authors.initials: MJ
authors.lastname: Coppes
authors.forename: K
authors.initials: K
authors.lastname: Jorgenson
authors.forename: J P
authors.initials: JP
authors.lastname: Arlette
mesh_terms: D000279:Administration, Cutaneous; D000293:Adolescent; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000627:therapeutic use; D000903:Antibiotics, Antineoplastic / Q000009:adverse effects*; D003609:Dactinomycin / Q000009:adverse effects*; D003875:Drug Eruptions / Q000188:drug therapy / Q000209:etiology*; D004890:Erythema / Q000139:chemically induced* / Q000188:drug therapy; D005260:Female; D005938:Glucocorticoids; D006801:Humans; D017495:Hyperpigmentation / Q000139:chemically induced / Q000188:drug therapy; D007680:Kidney Neoplasms / Q000188:drug therapy / Q000532:radiotherapy; D000068656:Mometasone Furoate; D011244:Pregnadienediols / Q000008:administration & dosage / Q000627:therapeutic use; D009396:Wilms Tumor / Q000188:drug therapy / Q000532:radiotherapy
chemical_list: D000893:Anti-Inflammatory Agents; D000903:Antibiotics, Antineoplastic; D005938:Glucocorticoids; D011244:Pregnadienediols; D000068656:Mometasone Furoate; D003609:Dactinomycin