[The effect of heparin on the activity of the mono-oxygenase glucuronyl- and glutathione transferase systems in ultrasonic damage to the rat liver].
Six days after local exposure of the rat liver (during operation) to ultrasound (2 W/cm2, 1 min), the cytochrome P-450 content in the microsomal fraction reduced, and the rate of NADPH oxidation, the NADPH cytochrome P-450 reductase activity, ethylmorphine demethylation and aniline hydroxylation decreased in 12 days the activity of NADPH-cytochrome b5 reductase and cytosol sulfobromophthalein-glutathione-S-transferase also reduced. Heparin administration (250 U/kg i.m. every other day 3 and 6 times) had an enzyme-activating effect (particularly in the late-term restoration period) in animals which had been exposed to ultrasound.
Eĭsmont
K A
KA
Bushma
M I
MI
Mal'chik
S S
SS
Bushma
T V
TV
Legon'kova
L F
LF
Zverinskiĭ
I V
IV
D000818:Animals; D004789:Enzyme Activation / Q000187:drug effects; D014453:Glucuronosyltransferase / Q000187:drug effects* / Q000378:metabolism; D005982:Glutathione Transferase / Q000187:drug effects* / Q000378:metabolism; D006493:Heparin / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000293:injuries*; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects* / Q000201:enzymology; D051381:Rats; D013997:Time Factors; D014465:Ultrasonics / Q000009:adverse effects*
D006493:Heparin; D014453:Glucuronosyltransferase; D005982:Glutathione Transferase