MIB1 immunopositivity is associated with rapid regrowth of pituitary adenomas.
Pituitary adenomas are generally regarded as benign tumours, but they may recur. We identified eight patients with pituitary adenomas that showed rapid regrowth within 2 years of initial surgery. We estimated the percentage of cells in each specimen that showed positive immunostaining for MIB1 (a novel anti-Ki-67) and compared the values to those of 40 adenomas that showed no regrowth. The mean MIB1 index for 40 adenomas that showed no evidence of regrowth was 0.19 +/- 0.06%. This was significantly (p < 0.0001) lower than that for adenomas that showed rapid regrowth (1.27 +/- 0.31%), based on the initial resected specimens. Immediately after detection of rapid regrowth and in adenomas that were resistant to bromocriptine or irradiation, the MIB1 index was always greater than 1.0%. Most patients with rapidly regrowing adenomas were well controlled by radiation therapy. Our results suggest that a MIB1 index greater than 1.0% may be a useful predictor of rapid regrowth of pituitary adenomas and may be useful for planning of therapy.
Mizoue
T
T
Department of Neurosurgery, Hiroshima University School of Medicine, Japan.
Kawamoto
H
H
Arita
K
K
Kurisu
K
K
Tominaga
A
A
Uozumi
T
T
D000236:Adenoma / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D000324:Adrenocorticotropic Hormone / Q000032:analysis; D000328:Adult; D000911:Antibodies, Monoclonal; D014408:Biomarkers, Tumor / Q000032:analysis*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000032:analysis; D019382:Human Growth Hormone / Q000032:analysis; D006801:Humans; D007016:Hypophysectomy; D007124:Immunoenzyme Techniques; D019394:Ki-67 Antigen / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D009384:Paraneoplastic Endocrine Syndromes / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D010902:Pituitary Gland / Q000473:pathology; D010911:Pituitary Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D011237:Predictive Value of Tests; D011388:Prolactin / Q000032:analysis; D014057:Tomography, X-Ray Computed
D000911:Antibodies, Monoclonal; D014408:Biomarkers, Tumor; D019394:Ki-67 Antigen; D019382:Human Growth Hormone; D000324:Adrenocorticotropic Hormone; D011388:Prolactin; D005640:Follicle Stimulating Hormone