SV-IV, a major protein secreted from rat seminal vesicle epithelium, promotes lymphocyte cytotoxic activity against the lymphoblastoid Raji cell line in human peripheral blood mononuclear cells.
The treatment of human peripheral blood mononuclear cells (PBMC) with micromolar concentrations of SV-IV, a major protein secreted from the rat seminal vesicle epithelium, promotes in this cell population a marked cytotoxic activity against the Raji lymphoblastoid cell line. This activity is apparently due to cell-to-cell contact interactions. The expression of HLA DR on Raji cells has a modulatory effect on the SV-IV-induced cytotoxic activity. The experimental evidence strongly suggests that the cytotoxic effector cells are functionally activated NK cells.
Peluso
G
G
CNR Institute of Protein Biochemistry and Enzymology, Naples, Italy.
Marchese
M
M
Furgi
A
A
Ranieri
M
M
Russo Spena
S
S
Ravagnan
G
G
Fuggetta
M P
MP
Porta
R
R
Metafora
V
V
Metafora
S
S
D000818:Animals; D003602:Cytotoxicity, Immunologic; D004848:Epithelium / Q000378:metabolism; D006801:Humans; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D011506:Proteins / Q000276:immunology* / Q000378:metabolism; D051381:Rats; D029607:Seminal Vesicle Secretory Proteins; D012669:Seminal Vesicles / Q000378:metabolism*; D014407:Tumor Cells, Cultured
D011506:Proteins; D029607:Seminal Vesicle Secretory Proteins; C101178:Svs4 protein, rat