title: Development and efficacy of a vaccine against Streptococcus iniae infection in farmed rainbow trout.
abstract: Formalin killed bacteria were used as a vaccine against Streptococcus iniae infections in farmed rainbow trout. A single intraperitoneal injection of this vaccine in trout resulted in specific antibody production detectable for 6 months. Trout vaccinated at 50 g were protected under laboratory (experimental disease) and field conditions (natural disease) for at least 4 months against S. iniae infection. Passive transfer of S. iniae specific antibodies conferred protection. Under field conditions, mortality of non vaccinated trout exceeded 50%, whereas mortality of vaccinated trout did not reach 5%. In addition, vaccinated trout under field conditions gained 20% weight when compared with non vaccinated fish.
authors.affiliation: Department of Clinical Microbiology, Hebrew University-Hadassah Medical School, Jerusalem, Israel.
authors.forename: A
authors.initials: A
authors.lastname: Eldar
authors.forename: A
authors.initials: A
authors.lastname: Horovitcz
authors.forename: H
authors.initials: H
authors.lastname: Bercovier
mesh_terms: D000372:Agglutination Tests / Q000662:veterinary; D000818:Animals; D000942:Antigens, Bacterial / Q000276:immunology; D001428:Bacterial Vaccines / Q000096:biosynthesis / Q000276:immunology*; D005393:Fish Diseases / Q000276:immunology / Q000517:prevention & control*; D005398:Fisheries; D017686:Oncorhynchus mykiss; D013290:Streptococcal Infections / Q000276:immunology / Q000517:prevention & control* / Q000662:veterinary*; D013291:Streptococcus / Q000276:immunology*; D014611:Vaccination / Q000662:veterinary
chemical_list: D000942:Antigens, Bacterial; D001428:Bacterial Vaccines