[Effects of thermal injury on heart sialic acid content in rats].
The myocardial sialic acid content, ATPase activities, and Ca2+ level were investigated in rats with full thickness burn of 30% TBSA. The results showed that the burned rats had a decreased level of myocardial sialic acid which was only 58.8% of controls at 3 h postburn. Myocardial Na+, K(+)-ATPase, Ca2+, Mg(2+)-ATPase and Ca(2+)-ATPase activities were inhibited in burned rats. As compared to controls, the burned rats showed a higher level of Ca2+ in heart tissue. This study indicated that there were abnormal energy metabolism, dysfunction of ion pump, and paradox Ca2+ overload in burned rats, which may be associated with the decrease in sialic acid content in myocardium.
Huan
J
J
Burn Institute, Changhai Hospital.
Huo
L
L
Chen
Y
Y
D000818:Animals; D002056:Burns / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012794:Sialic Acids / Q000378:metabolism*; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism
D012794:Sialic Acids; D000254:Sodium-Potassium-Exchanging ATPase