[V gene repertoire and pathogenic autoantibodies].
The studies for autoantibody-associated V genes have failed to find any V gene which might be specific for pathogenic autoantibodies in humans; Namely, both normal subjects and patients have immunoglobulin V genes which can encode autoantibodies. Also single V gene can encode antibodies for both foreign antigens and autoantigens. However, some germline V genes such as V3-7 and VH4-21 are preferentially used for autoantibodies and may be regarded as prototype V genes for autoantibodies. Although somatic mutation in V genes is characteristic in IgG autoantibodies, 0-81 idiotype-positive IgM antibodies, which may be precursor B cells for pathogenic anti-DNA antibody also included many somatic mutations in VH genes, indicating an intrinsic abnormality in B cell development in SLE. Some studies also indicated an abnormal V gene repertoire in autoimmune states. These results may be attributed to dysregulation of autoantibody-associated B cell development.
Hirabayashi
Y
Y
Department of Internal Medicine, Tohoku University School of Medicine.
Munakata
Y
Y
Saitou
S
S
Sasaki
T
T
D000818:Animals; D000974:Antibodies, Antinuclear / Q000235:genetics*; D001327:Autoimmune Diseases / Q000209:etiology; D001402:B-Lymphocytes / Q000276:immunology; D017637:Clonal Deletion; D015321:Gene Rearrangement; D005803:Genes, Immunoglobulin; D006239:Haplotypes; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000276:immunology; D009154:Mutation
D000974:Antibodies, Antinuclear