Vascular remodeling and mineralocorticoids.
Circulating mineralocorticoid hormones are so named because of their important homeostatic properties that regulate salt and water balance via their action on epithelial cells. A broader range of functions in nonclassic target cellular sites has been proposed for these steroids and includes their contribution to wound healing following injury. A chronic, inappropriate (relative to intravascular volume and dietary sodium intake) elevation of these circulating hormones evokes a wound healing response in the absence of tissue injury--a wound healing response gone awry. The adverse remodeling of vascularized tissues seen in association with chronic mineralocorticoid excess is the focus of this review.
Weber
K T
KT
Department of Internal Medicine, University of Missouri Health Sciences Center, Columbia, USA.
Sun
Y
Y
Campbell
S E
SE
Slight
S H
SH
Ganjam
V K
VK
D000450:Aldosterone / Q000009:adverse effects* / Q000378:metabolism; D000818:Animals; D005347:Fibroblasts / Q000187:drug effects / Q000378:metabolism; D006706:Homeostasis; D006801:Humans; D008901:Mineralocorticoids / Q000009:adverse effects / Q000502:physiology*; D009131:Muscle, Smooth, Vascular / Q000187:drug effects* / Q000473:pathology*; D018161:Receptors, Mineralocorticoid / Q000187:drug effects
D008901:Mineralocorticoids; D018161:Receptors, Mineralocorticoid; D000450:Aldosterone