title: The structure, function, and assembly of actin filament bundles.
abstract: The cellular organization, function, and molecular composition of selected biological systems with prominent actin filament bundles are reviewed. An overall picture of the great variety of functions served by actin bundles emerges from this overview. A unifying theme is that the actin cross-linking proteins are conserved throughout the eukaryotic kingdom and yet assembled in a variety of combinations to produce actin bundles of differing functions. Mechanisms of actin bundle formation in vitro are considered illustrating the variety of physical and chemical driving forces in this exceedingly complex process. Our limited knowledge regarding the formation of actin filament bundles in vivo is contrasted with the elegant biophysical studies performed in vitro but nonetheless reveals that interactions with membranes, nucleation sites, and other organizational components must contribute to formation of actin bundles in vivo.
authors.affiliation: Department of Cellular Biology, University of Georgia, Athens 30602, USA.
authors.forename: R
authors.initials: R
authors.lastname: Furukawa
authors.forename: M
authors.initials: M
authors.lastname: Fechheimer
mesh_terms: D008841:Actin Cytoskeleton / Q000378:metabolism / Q000502:physiology / Q000648:ultrastructure; D000199:Actins / Q000378:metabolism / Q000502:physiology; D000818:Animals; D002478:Cells, Cultured; D006801:Humans
chemical_list: D000199:Actins