title: Osteosarcoma following total hip arthroplasty in a dog.
abstract: Osteosarcoma involving the distal right femur was diagnosed in a nine-year-old female neutered Rottweiler seven years after total hip arthroplasty had been performed on that limb. The findings were consistent with a primary bone tumour and pathological fracture of the right femoral condyle with loosening of the orthopaedic implant and fracture of the polymethylmethacrylate at the distal aspect of the femoral component. Possible hypotheses to explain the association of osteosarcoma with total hip arthroplasty suggest that the neoplastic process was the result of some derangement of host tissue and the healing process or that the implants or their by-products were carcinogenic. Given the large number of total hip arthroplasties that are routinely performed in dogs, the development of a malignant lesion appears to be an extraordinary complication and may be completely coincidental.
authors.affiliation: Department of Small Animal Clinical Sciences, University of Florida, College of Veterinary Medicine, Gainesville 32610-0126, USA.
authors.forename: S T
authors.initials: ST
authors.lastname: Murphy
authors.forename: R B
authors.initials: RB
authors.lastname: Parker
authors.forename: J C
authors.initials: JC
authors.lastname: Woodard
mesh_terms: D000818:Animals; D001859:Bone Neoplasms / Q000175:diagnosis / Q000209:etiology / Q000662:veterinary*; D004283:Dog Diseases / Q000209:etiology* / Q000473:pathology; D004285:Dogs; D005260:Female; D006615:Hip / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D006622:Hip Prosthesis / Q000009:adverse effects / Q000662:veterinary*; D009336:Necrosis; D012516:Osteosarcoma / Q000175:diagnosis / Q000209:etiology / Q000662:veterinary*; D011859:Radiography