Calretinin-containing neurons in trimethyltin-induced neurodegeneration in the rat hippocampus: an immunocytochemical study.
The present study uses immunocytochemistry to investigate the behavior of the calretinin (CR)-containing neuronal subpopulation (interneurons) of the rat hippocampus in neurodegenerative processes induced by the neurotoxicant trimethyltin. Cell counts of CR-immunolabeled interneurons indicated that these cells are spared by the neurotoxicant-induced degeneration, characterized by a generalized neuronal loss, as shown by quantitative analysis after cresyl violet staining.
Geloso
M C
MC
Institute of Histology, Catholic University, Rome, Italy.
Vinesi
P
P
Michetti
F
F
D000818:Animals; D048588:Benzoxazines; D064032:Calbindin 2; D004396:Coloring Agents; D005260:Female; D006624:Hippocampus / Q000166:cytology / Q000187:drug effects* / Q000473:pathology; D007150:Immunohistochemistry; D007395:Interneurons / Q000166:cytology / Q000187:drug effects* / Q000473:pathology; D009410:Nerve Degeneration / Q000187:drug effects*; D009419:Nerve Tissue Proteins / Q000032:analysis; D009474:Neurons / Q000166:cytology / Q000187:drug effects* / Q000473:pathology; D009498:Neurotoxins / Q000633:toxicity*; D010078:Oxazines; D051381:Rats; D017208:Rats, Wistar; D064030:S100 Calcium Binding Protein G / Q000032:analysis*; D014298:Trimethyltin Compounds / Q000633:toxicity*
D048588:Benzoxazines; C576512:Calb2 protein, rat; D064032:Calbindin 2; D004396:Coloring Agents; D009419:Nerve Tissue Proteins; D009498:Neurotoxins; D010078:Oxazines; D064030:S100 Calcium Binding Protein G; D014298:Trimethyltin Compounds; C046488:trimethyltin; C028911:cresyl violet