Deregulation of cell survival in lymphomagenesis.
Because normal lymphoid tissue homeostasis depends on a balance between cell proliferation and cell death, lymphomas can arise from mutations that interfere with the normal cell death process. We here discuss some circumstances in which lymphoid cell overexpression of a cell death antagonist, the Bcl2 protein, in E mu-bcl2 transgenic mice can contribute to the development of lymphomas and plasmacytomas.
Harris
A W
AW
Walter & Eliza Hall Institute of Medical Research, PO Royal Melbourne Hospital, Melbourne, Australia.
Strasser
A
A
Elefanty
A G
AG
Bath
M L
ML
Cory
S
S
D000818:Animals; D002454:Cell Differentiation; D002470:Cell Survival; D003433:Crosses, Genetic; D016313:Genes, abl; D006706:Homeostasis; D006801:Humans; D015994:Incidence; D008223:Lymphoma / Q000453:epidemiology / Q000235:genetics*; D016399:Lymphoma, T-Cell / Q000453:epidemiology / Q000235:genetics / Q000473:pathology; D051379:Mice; D008810:Mice, Inbred C57BL; D008815:Mice, Inbred Strains; D008822:Mice, Transgenic; D010954:Plasmacytoma / Q000453:epidemiology / Q000235:genetics; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000096:biosynthesis* / Q000235:genetics; D013953:Thymus Neoplasms / Q000453:epidemiology / Q000235:genetics; D014407:Tumor Cells, Cultured
D019253:Proto-Oncogene Proteins c-bcl-2