[Effect of concentrated xuefu zhuyu pill on proliferation of vascular smooth muscle cells in experimental atheriosclerosis rabbits observed by serologic pharmacological test].
Two in vitro experiments were performed for comparative study to evaluate the effect of concentrated Xuefu Zhuyu pill (CXZP), a Chinese traditional herbal medicinal mixture, on the proliferation of vascular smooth muscle cells (SMCs) of experimental atherosclerosis rabbits by serologic pharmacological test. The first experiment approach adopted the addition of the rabbit's serum to the culture medium while in the second experiment the CXZP was added to the medium directly. Results showed that both the serum with CXZP and the CXZP extract itself could inhibit the proliferation of SMC significantly and dose-dependently, and the inhibitory action of the latter was more potent than the former one. It suggested that CXZP could inhibit the proliferation of SMC both in vivo and in vitro, the decrease of effectiveness in vivo might be due to the non-absorption of some active ingredient of CXZP or due to metabolic inactivation.
Zhang
Q H
QH
Xiyuau Hospital, China Academy of TCM, Beijing.
Zhong
B
B
Chen
K J
KJ
D000818:Animals; D001011:Aorta / Q000473:pathology; D001161:Arteriosclerosis / Q000473:pathology*; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D004247:DNA / Q000096:biosynthesis; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000473:pathology*; D011817:Rabbits
D004365:Drugs, Chinese Herbal; D004247:DNA