A role for ultraspiracle, the Drosophila RXR, in morphogenetic furrow movement and photoreceptor cluster formation.
Many of the same genes needed for proper eye and limb development in vertebrates, such as hairy, hedgehog, patched and cyclic AMP-dependent protein kinase A, are responsible for patterning Drosophila imaginal discs, the tissues that will give rise to the adult cuticle structures. This is well demonstrated in the control of morphogenetic furrow movement and differentiation in the eye imaginal disc. We report that ultraspiracle, the gene encoding the Drosophila cognate of the Retinoid X Receptor, is required for normal morphogenetic furrow movement and ommatidial cluster formation. Examination of the expression of genes involved in regulating the furrow suggests that ultraspiracle defines a novel regulatory pathway in eye differentiation.
Zelhof
A C
AC
Molecular Biology and Virology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
Ghbeish
N
N
Tsai
C
C
Evans
R M
RM
McKeown
M
M
D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins; D019521:Body Patterning; D002450:Cell Communication; D002454:Cell Differentiation; D002465:Cell Movement; D017868:Cyclic AMP-Dependent Protein Kinases / Q000302:isolation & purification; D004268:DNA-Binding Proteins / Q000302:isolation & purification / Q000378:metabolism*; D004330:Drosophila / Q000196:embryology*; D029721:Drosophila Proteins; D005121:Extremities / Q000196:embryology; D005123:Eye / Q000196:embryology*; D018257:Helix-Loop-Helix Motifs; D007150:Immunohistochemistry; D019476:Insect Proteins / Q000302:isolation & purification; D008565:Membrane Proteins / Q000302:isolation & purification; D009024:Morphogenesis; D010641:Phenotype; D017956:Photoreceptor Cells, Invertebrate / Q000196:embryology*; D011956:Receptors, Cell Surface; D018168:Receptors, Retinoic Acid; D012097:Repressor Proteins / Q000302:isolation & purification; D047488:Retinoid X Receptors; D013045:Species Specificity; D014157:Transcription Factors / Q000378:metabolism*
D051792:Basic Helix-Loop-Helix Proteins; D017868:Cyclic AMP-Dependent Protein Kinases; D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; D019476:Insect Proteins; D008565:Membrane Proteins; D011956:Receptors, Cell Surface; D018168:Receptors, Retinoic Acid; D012097:Repressor Proteins; D047488:Retinoid X Receptors; D014157:Transcription Factors; C066030:USP protein, Drosophila; C064196:dpp protein, Drosophila; C063577:emc protein, Drosophila; C489235:hairy protein, Drosophila; C070844:ptc protein, Drosophila; C061841:hairy protein, insect