[Effect of the T4 on the viscera and embryo of perinatal mice].
58 Female Kun Ming mice of perinatal stage (from the 15th day of pregnacy to the 21th day after birth) were fed with Tripcholorolide (T4) isolated from multiglycosides of Tripterygium wilfordii (GTW) at a doze of 0.6 mg/kg for group 1 or 0.3 mg/kg for group 2 per day for 4 weeks. Lactation was decreased in some females and some F1 off spring died. The succinic dehydrogenase (SDH) activity of the mice liver were increased due to the destruction of its mitocondian. Liver cells degenerated and glycogen decreased. Distal tubules of kidney degenerated. Heart and spleen were normal. T4 was also fed to 10 female mice from the 5th to 17th day of pregnacy. However, neither the absorbed fetus nor dead fetus increased.
Dan
L
L
Institute of Basic Medical Sciences, CAMS, Beijing.
Ye
W
W
Guo
Y
Y
Han
Y
Y
Liu
P
P
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000633:toxicity; D004224:Diterpenes / Q000302:isolation & purification / Q000633:toxicity*; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D004622:Embryo, Mammalian / Q000187:drug effects*; D005260:Female; D005313:Fetal Death / Q000139:chemically induced; D005327:Fetal Resorption / Q000139:chemically induced; D007166:Immunosuppressive Agents / Q000633:toxicity; D007686:Kidney Tubules, Distal / Q000187:drug effects; D007774:Lactation / Q000187:drug effects; D008099:Liver / Q000378:metabolism; D008112:Liver Glycogen / Q000378:metabolism; D051379:Mice; D008930:Mitochondria, Liver / Q000378:metabolism; D011247:Pregnancy; D013385:Succinate Dehydrogenase / Q000378:metabolism*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004224:Diterpenes; D004365:Drugs, Chinese Herbal; D007166:Immunosuppressive Agents; D008112:Liver Glycogen; D013385:Succinate Dehydrogenase