title: Bootstrap tests for specific hypotheses at single locus inbreeding coefficients.
abstract: Deviations of genotype distribution from Hardy-Weinberg expectations within a (sub)population can give valuable insight into the population structure, and can be quantified by means of F(is) values. Specific biological and/or genetical hypotheses regarding F(is) require particular statistical procedures to be able to perform the test with high power. The bootstrap offers a convenient way to test against a broad range of alternative hypotheses. It enables: a) comparison of an observed F(is) with any expected value between -1 and 1, and b) comparison of two or more observed F(is) values. However, it fails under numerous situations, and great caution should be taken before applying the bootstrap to estimate confidence intervals of F(is). We discuss under which conditions the bootstrap gives reliable results.
authors.affiliation: Department of Biology, University of Antwerp, Wilrijk, Belgium.
authors.forename: S
authors.initials: S
authors.lastname: Van Dongen
authors.forename: T
authors.initials: T
authors.lastname: Backeljau
mesh_terms: D005787:Gene Frequency; D005828:Genetics, Population; D007178:Inbreeding; D009010:Monte Carlo Method; D013223:Statistics as Topic