The kidney and hypertension.
The kidney is important not only as a target organ of hypertension but also as a organ that may cause hypertension. For many years, we have studied basic and clinical aspects of the role of the kidney in hypertension, including the renin-angiotensin, kallikrein-kinin, and prostaglandin systems, glomerular hemodynamics, therapeutic modalities, and prognosis. This review summarizes some of our results together with those of other relevant studies in the literature.
Abe
K
K
Second Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan.
Ito
S
S
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D002121:Calcium Channel Blockers / Q000009:adverse effects / Q000494:pharmacology; D003404:Creatinine / Q000378:metabolism; D005665:Furosemide / Q000494:pharmacology; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology; D007022:Hypotension; D016234:Kallikrein-Kinin System / Q000502:physiology; D007668:Kidney / Q000502:physiology*; D011446:Prospective Studies; D011453:Prostaglandins / Q000502:physiology; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D051437:Renal Insufficiency / Q000150:complications; D012083:Renin / Q000378:metabolism; D012084:Renin-Angiotensin System / Q000502:physiology; D012964:Sodium / Q000652:urine
D002121:Calcium Channel Blockers; D011453:Prostaglandins; D005665:Furosemide; D012964:Sodium; D003404:Creatinine; D012083:Renin