Age-related changes of urinary nitrite/nitrate excretion in normal children.
We measured the urinary excretion of nitrite/nitrate, stable metabolites of nitric oxide, using the brucine method in 90 healthy normal children (47 boys and 43 girls), aged from 1.0 to 17.1 years, to establish the age-related normal range in children. The urinary nitrite/nitrate excretion was highest in the youngest children and decreased in an age-dependent manner to reach constant levels at about 12 years of age in both sexes. The data may be useful in identifying sick children with abnormal nitric oxide production.
Tsukahara
H
H
Department of Pediatrics, Fukui Medical School, Japan.
Hiraoka
M
M
Hori
C
C
Miyanomae
T
T
Kikuchi
K
K
Sudo
M
M
D000293:Adolescent; D000375:Aging / Q000652:urine*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D009566:Nitrates / Q000652:urine*; D009569:Nitric Oxide / Q000378:metabolism; D009573:Nitrites / Q000652:urine*; D012016:Reference Values
D009566:Nitrates; D009573:Nitrites; D009569:Nitric Oxide