Inhibition of growth in oral squamous carcinoma cells by cyclopentenone prostaglandins: comparison with chemotherapeutic agents.
Four cyclopentenone prostaglandins (CPPGs) and PGE2 caused significant dose-dependent inhibition in growth of human oral squamous carcinoma cells (SCC-15). The rank order of their potency was PGJ2>PGA1>16, 16-dimethyl PGA1>PGA2>PGE2. In a follow-up experiment it was found that the mean per cent inhibition in cell growth by PGJ2 and delta12-PGJ2 at 10(-5) M was 61.22 and 63.81, while that of 5-fluorouracil and methotrexate was 36.67 and 38.86, respectively. delta12-PGJ2 and PGJ2 induced significant dose-dependent inhibition in nuclear DNA synthesis (i.e. cell proliferation). Combining vitamin E succinate with lower concentrations of CPPGs enhanced significantly their inhibitory effect on nuclear DNA synthesis of cancer cells.
ElAttar
T M
TM
Hormone Research Laboratory, University of Missouri-Kansas City, Schools of Dentistry and Medicine, 64108, USA.
Virji
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AS
D000970:Antineoplastic Agents / Q000494:pharmacology*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy*; D002455:Cell Division / Q000187:drug effects; D015232:Dinoprostone / Q000494:pharmacology; D005472:Fluorouracil / Q000494:pharmacology; D006801:Humans; D008727:Methotrexate / Q000494:pharmacology; D009062:Mouth Neoplasms / Q000188:drug therapy*; D015230:Prostaglandin D2 / Q000031:analogs & derivatives / Q000494:pharmacology; D011454:Prostaglandins A / Q000494:pharmacology; D011455:Prostaglandins A, Synthetic / Q000494:pharmacology; D011465:Prostaglandins, Synthetic / Q000008:administration & dosage / Q000494:pharmacology*; D024505:Tocopherols; D014407:Tumor Cells, Cultured; D014810:Vitamin E / Q000008:administration & dosage / Q000031:analogs & derivatives
D000970:Antineoplastic Agents; D011454:Prostaglandins A; D011455:Prostaglandins A, Synthetic; D011465:Prostaglandins, Synthetic; D014810:Vitamin E; C078051:16,16-dimethylprostaglandin A1; C037112:9-deoxy-delta-9-prostaglandin D2; C100008:prostaglandin A2; D015232:Dinoprostone; D024505:Tocopherols; D015230:Prostaglandin D2; D005472:Fluorouracil; C100573:prostaglandin A1; D008727:Methotrexate