[Influence of qingdai compound capsule (QDCC) on the expression of c-myc in psoriatic keratinocytes].
In this immunohistochemical study the authors detected the expression of c-myc in keratinocytes (ECK) from 30 psoriatic patients before and after QDCC treatment and 12 normal subjects for control. The results showed that the ECK of patients before treatment was significantly higher than that in normal control, and its level was correlated with histopathological changes. After treatment the ECK was normalized. It is believed that QDCC could decrease the EKC in psoriatic patient and this effect probably was mediated by inhibiting c-myc expression. This study provided an experimental evidence for the application of QDCC in treating psoriasis.
Feng
J
J
Department of Dermatology, Second Affiliated Hospital, Xi'an Medical University.
Xu
H Q
HQ
Su
B S
BS
D000293:Adolescent; D000328:Adult; D002648:Child; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D015870:Gene Expression / Q000187:drug effects; D016259:Genes, myc; D006801:Humans; D015603:Keratinocytes / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D016271:Proto-Oncogene Proteins c-myc / Q000378:metabolism*; D011565:Psoriasis / Q000188:drug therapy / Q000235:genetics*
D004365:Drugs, Chinese Herbal; D016271:Proto-Oncogene Proteins c-myc