Wegener's granulomatosis in pregnancy.
This report describes a case of severe limited Wegener's granulomatosis (WG) presenting in the third trimester of pregnancy with pansinusitis and necrotizing pneumonitis. The patient was treated successfully with a combination of corticosteroids and cyclophosphamide (CYC). The outcomes in the mother and the newborn were excellent. In a review of the English-language literature, we found 10 similar cases of WG with 13 pregnancies. WG occurring during pregnancy may have a more aggressive course and may require more aggressive treatment compared with WG occurring at other times. The treatment options for WG in pregnancy are discussed.
Luisiri
P
P
University of Chicago, Illinois 60637, USA.
Lance
N J
NJ
Curran
J J
JJ
D000328:Adult; D003520:Cyclophosphamide / Q000008:administration & dosage; D005260:Female; D014890:Granulomatosis with Polyangiitis / Q000188:drug therapy* / Q000503:physiopathology*; D006801:Humans; D008775:Methylprednisolone / Q000008:administration & dosage; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy* / Q000503:physiopathology*; D011256:Pregnancy Outcome; D011263:Pregnancy Trimester, Third
D003520:Cyclophosphamide; D008775:Methylprednisolone