title: Hyaluronidase and peribulbar block.
abstract: We have assessed the effect of two concentrations of hyaluronidase on the quality of peribulbar block, using a low volume, single injection technique. We studied 200 patients undergoing elective intraocular surgery, allocated randomly to one of three groups. Group 1 (n = 50) received peribulbar block with 5 ml of a 1:1 mixture of 0.5% plain bupivacaine and 2% plain lignocaine. Group 2 (n = 75) received this solution supplemented with hyaluronidase 50 iu ml-1. Group 3 (n = 75) received the same solution supplemented with hyaluronidase 300 iu ml-1. Lack of ocular motility was considered to be the only objective sign of successful block and movement of each rectus muscle was scored at 1-, 5- and 10-min intervals. If the block was successful at 5 min, the 10-min score was omitted. If the block was unsuccessful at 5 min, a second injection of 2% lignocaine 3 ml was given and additional assessments performed at 5-min intervals. At 1 min, ocular motility scores were significantly lower in group 3 compared with the control group (P < 0.05). The incidence of satisfactory block at 5 min was increased in both groups given hyaluronidase (group 2, P < 0.05; group 3, P < 0.001). There were no significant differences between groups 2 and 3 with respect to quality of block at 5 min. Hyaluronidase in both concentrations improved the quality of peribulbar block at 5 min, and when used in a concentration of 300 iu ml-1, also improved the speed of onset of block.
authors.affiliation: Aintree Hospitals NHS Trust, Liverpool.
authors.forename: G A
authors.initials: GA
authors.lastname: Dempsey
authors.forename: P J
authors.initials: PJ
authors.lastname: Barrett
authors.forename: I J
authors.initials: IJ
authors.lastname: Kirby
mesh_terms: D000759:Adjuvants, Anesthesia / Q000008:administration & dosage*; D000368:Aged; D000369:Aged, 80 and over; D000772:Anesthesia, Local / Q000379:methods*; D019162:Anesthetics, Combined; D002045:Bupivacaine; D004305:Dose-Response Relationship, Drug; D005133:Eye Movements / Q000187:drug effects; D005260:Female; D006801:Humans; D006821:Hyaluronoglucosaminidase / Q000008:administration & dosage*; D008012:Lidocaine; D008297:Male; D008875:Middle Aged; D013508:Ophthalmologic Surgical Procedures
chemical_list: D000759:Adjuvants, Anesthesia; D019162:Anesthetics, Combined; D008012:Lidocaine; D006821:Hyaluronoglucosaminidase; D002045:Bupivacaine