Ascitic growth of a T cell lymphoma in mice alters the humoral and cellular immune response to exogenous antigens.
The effect of the ascitic growth of Dalton's lymphoma (DL), a T cell lymphoma, on the immune responses of the host mice to exogenous antigens, with respect to the humoral response, delayed-type hypersensitivity (DTH) response and the antigen-presenting ability of macrophages was investigated. The humoral immune response to sheep red blood cells (SRBC) as well as the antigen-presenting ability of macrophages (with keyhole limpet hemocyanin as the standard antigen) in the DL-bearing mice were consistently higher than in the normal mice, although the magnitude showed a decline during later tumor stages. However, the DTH response to SRBC was suppressed in the DL-bearing mice compared with the response in the normal mice. The possible mechanisms are discussed. In vivo administration of FK565, a synthetic biological response modifier, enhanced the humoral immune response as well as the antigen-presenting ability of the macrophages in the normal and early DL-bearing mice, whereas these immune responses n the later tumor-bearing animals were found to be nonresponsive to FK565 treatment. In contrast, the DTH response in the normal as well as in the DL-bearing mice was suppressed on FK565 administration. This is the first study of its kind regarding the effect of the ascitic growth of any T cell lymphoma on various aspects of the immune response to exogenous antigens and the correlation thereof with an immunomodulator.
Parajuli
P
P
Department of Zoology, University of Delhi, India.
Singh
S M
SM
D000276:Adjuvants, Immunologic / Q000494:pharmacology; D000818:Animals; D000917:Antibody Formation; D000938:Antigen-Presenting Cells / Q000276:immunology; D001201:Ascites / Q000473:pathology*; D005260:Female; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007111:Immunity, Cellular; D016399:Lymphoma, T-Cell / Q000276:immunology* / Q000473:pathology*; D008264:Macrophages / Q000276:immunology; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D009842:Oligopeptides / Q000494:pharmacology; D013047:Specific Pathogen-Free Organisms
D000276:Adjuvants, Immunologic; D009842:Oligopeptides; C039537:heptanoyl-gamma-D-glutamyl-L-meso-diaminopimelyl-D-alanine