Lack of effect of endogenous corticosteroids on the acute inflammatory reaction (edema) induced by Bothrops jararaca venom (BjV) in rats.
Intraplantar injection of 5 or 10 micrograms of BjV caused local edema in rats that was not affected by ablation of adrenal glands. In addition, no changes in plasma corticosterone levels were observed. Simultaneous injections of the venom into both hindpaws of normal animals, or injections made at varying intervals, resulted in local inflammatory reactions of comparable time-course development and analogous magnitude. These data might be related to an inability of the venom to evoke secretion of corticosteroids.
Cury
Y
Y
Laboratory of Pathophysiology, Instituto Butantan, São Paulo, Brazil.
Teixeira
C F
CF
Farsky
S H
SH
D000315:Adrenalectomy; D000818:Animals; D017837:Bothrops; D003345:Corticosterone / Q000097:blood*; D003435:Crotalid Venoms / Q000008:administration & dosage*; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D005121:Extremities / Q000473:pathology; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D003435:Crotalid Venoms; D003345:Corticosterone