title: [Conversion of chronic necrotizing pulmonary aspergillosis to invasive pulmonary aspergillosis, and successful treatment with fluconazole].
abstract: An 82-year-old man with rheumatoid arthritis was admitted to the hospital because of bloody sputum, appetite loss, and a chest-radiographic abnormality. He had previously been treated with oral steroid therapy. The chest X-ray film showed an infiltrative shadow with airlucency in the right upper lung field. Sputum culture for fungi was negative, but a test for aspergillus antigen in serum was positive. Other clinical findings were also compatible with conversion of chronic necrotizing pulmonary aspergillosis to invasive pulmonary aspergillosis. The patient was successfully treated with a drip infusion of fulconazole. The patients condition was stable for several months, after which he died due to uncontrollable atrial flutter. Mild immunosuppression due to oral steroid therapy probably caused chronic necrotizing pulmonary aspergillosis in this case. The patient's general condition worsened after admission and invasive pulmonary aspergillosis developed. This case taught us that therapy for chronic necrotizing pulmonary aspergillosis should include management of the patient's general condition as well as treatment of the pulmonary lesions.
authors.affiliation: Department of Internal Medicine, National Seiransou Hospital, Ibaraki, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Hirano
authors.forename: T
authors.initials: T
authors.lastname: Saitoh
authors.forename: K
authors.initials: K
authors.lastname: Kadono
authors.forename: H
authors.initials: H
authors.lastname: Oose
authors.forename: S
authors.initials: S
authors.lastname: Watanabe
authors.forename: S
authors.initials: S
authors.lastname: Hasegawa
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000893:Anti-Inflammatory Agents / Q000009:adverse effects; D000935:Antifungal Agents / Q000008:administration & dosage*; D001172:Arthritis, Rheumatoid / Q000150:complications; D001228:Aspergillosis / Q000188:drug therapy*; D002908:Chronic Disease; D018450:Disease Progression; D015725:Fluconazole / Q000008:administration & dosage*; D006801:Humans; D016867:Immunocompromised Host; D007262:Infusions, Intravenous; D008172:Lung Diseases, Fungal / Q000188:drug therapy*; D008297:Male; D009336:Necrosis; D011239:Prednisolone / Q000009:adverse effects
chemical_list: D000893:Anti-Inflammatory Agents; D000935:Antifungal Agents; D015725:Fluconazole; D011239:Prednisolone