Transgenic rabbit models for the study of atherosclerosis.
The rabbit rapidly develops severe hypercholesterolemia leading to premature atherosclerosis in response to dietary manipulation. Transgenic rabbit models with altered expression of specific genes will provide new approaches to understanding the underlying mechanisms that contribute to this disease. Recently established lines of transgenic rabbits that overexpress hepatic lipase and apolipoprotein E are yielding fresh insights into the functions of these proteins and their role in lesion development
Taylor
J M
JM
Gladstone Institute of Cardiovascular Disease , PO Box 419100, San Franscisco, CA 94141-9100, USA. john_taylor@quickmail.uscf.edu
Fan
J
J
D000071479:APOBEC-1 Deaminase; D000818:Animals; D030801:Animals, Genetically Modified; D016632:Apolipoprotein A-I / Q000235:genetics; D001055:Apolipoproteins B / Q000235:genetics; D001057:Apolipoproteins E / Q000235:genetics / Q000502:physiology; D001161:Arteriosclerosis / Q000209:etiology*; D003564:Cytidine Deaminase / Q000235:genetics; D004195:Disease Models, Animal; D006801:Humans; D008049:Lipase / Q000235:genetics / Q000502:physiology; D050356:Lipid Metabolism; D007862:Phosphatidylcholine-Sterol O-Acyltransferase / Q000235:genetics; D011817:Rabbits / Q000235:genetics*
D016632:Apolipoprotein A-I; D001055:Apolipoproteins B; D001057:Apolipoproteins E; C504173:LIPC protein, human; D007862:Phosphatidylcholine-Sterol O-Acyltransferase; D008049:Lipase; D000071479:APOBEC-1 Deaminase; C000605089:APOBEC1 protein, human; D003564:Cytidine Deaminase