A preliminary study of the analysis of Cannabis by supercritical fluid chromatography with atmospheric pressure chemical ionisation mass spectroscopic detection.
A rapid method is described for the analysis of Cannabis products by supercritical fluid chromatography (SFC) coupled to atmospheric pressure chemical ionization-mass spectroscopic (APCI-MS) detection. The method had a shorter analysis time than GC-MS methods, without the need for derivatization prior to analysis. It was also faster than HPLC methods, with better resolution and definitive identification. Linearity of detector response to cannabidiol, delta 8-tetrahydrocannabinol, delta 9-tetrahydrocannabinol and cannabinol was established, the detection limits for mass on column being 0.55 ng, 1.20 ng, 0.69 ng and 2.10 ng respectively. The technique offers a means by which Cannabis products can be definitively identified in a single chromatographic run. Application to casework samples is described.
Bäckström
B
B
Department of Pure and Applied Chemistry, University of Strathclyde, Glasgow, United Kingdom.
Cole
M D
MD
Carrott
M J
MJ
Jones
D C
DC
Davidson
G
G
Coleman
K
K
D002186:Cannabinoids / Q000032:analysis*; D002188:Cannabis / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D002853:Chromatography, Liquid / Q000379:methods*; D013759:Dronabinol / Q000032:analysis; D008401:Gas Chromatography-Mass Spectrometry; D013058:Mass Spectrometry
D002186:Cannabinoids; D013759:Dronabinol