title: Clonal chromosome aberrations in three of five sporadic angiomyolipomas of the kidney.
abstract: Clonal chromosomal changes were detected in three of five sporadic angiomyolipomas of the kidney irrespective of a solitary or multifocal appearance of this benign tumor type. No specific chromosomal changes have been identified. Including the cytogenetic data of the four renal angiomyolipomas reported in the literature, trisomy 7 as the single clonal chromosomal abnormality was detected in two angiomyolipomas. Because trisomy 7 has been reported in both neoplastic and nonneoplastic kidney cells, it may be assumed that trisomy 7 is already physiologically resident in renal cells but undergoes positive selection in this tumor type.
authors.affiliation: Clinic of Urology and Pediatric Urology, University of the Saarland, Homburg/Saar, Germany.
authors.forename: B
authors.initials: B
authors.lastname: Wullich
authors.forename: W
authors.initials: W
authors.lastname: Henn
authors.forename: S
authors.initials: S
authors.lastname: Siemer
authors.forename: G
authors.initials: G
authors.lastname: Seitz
authors.forename: A
authors.initials: A
authors.lastname: Freiler
authors.forename: K D
authors.initials: KD
authors.lastname: Zang
mesh_terms: D000328:Adult; D018207:Angiomyolipoma / Q000235:genetics* / Q000473:pathology; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D007680:Kidney Neoplasms / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged