[Inhibition of corneal neovascularization by a new analog of fungal product].
The anti-angiogenic activity if FR 118487, a new synthetic analogue of Scolecobasidium arenarium products, was examined in corneas of Japanese white rabbits. We studied locally administered FR 118487 with hydron pellets in two models; corneal neovascularization after implantation of a CuCl2 pellet (CuCl2-induced model) and a Wistar rat's cornea (keratoplasty model) into a rabbit cornea. In the CuCl2-induced model, maximum length of neovascularization was 0.08 +/- 0.10 (mean +/- standard deviation) mm with FR 118487 (control 2.84 +/- 0.13 mm) at 1 week after the implantation. In the keratoplasty model, maximum length of neovascularization was 0.05 +/- 0.05 mm with FR 118487 (control 3.33 +/- 0.18 mm) at 2 weeks after the implantation. In both models, FR 118487 had a significant (p < 0.01) effect on inhibition of corneal neovascularization.
Nii
S
S
Department of Ophthalmology, School of Medicine, Keio University, Tokyo, Japan.
Idei
T
T
Terano
H
H
Mashima
Y
Y
D000818:Animals; D003300:Copper; D016510:Corneal Neovascularization / Q000139:chemically induced / Q000188:drug therapy*; D016039:Corneal Transplantation / Q000009:adverse effects; D004195:Disease Models, Animal; D005260:Female; D005658:Fungi; D011817:Rabbits; D051381:Rats; D017208:Rats, Wistar; D013141:Spiro Compounds / Q000627:therapeutic use*
C096036:FR 118487; D013141:Spiro Compounds; D003300:Copper; C028419:cuprous chloride