title: Changes in cardiac adrenomedullin concentration in renovascular hypertensive rats.
abstract: We assessed changes in tissue and plasma adrenomedullin levels in two-kidney, one-clip renovascular hypertensive rats. Four weeks after clipping, adrenomedullin concentrations were significantly higher in the cardiac ventricles and lower in the left atrium than the respective values in sham-operated rats. The left ventricular adrenomedullin concentration significantly correlated with systolic blood pressure and the degree of cardiac hypertrophy. No difference was noted in the adrenomedullin concentrations of the adrenal gland, aorta, lung, kidneys, or plasma between the two groups. These findings indicate possible involvement of cardiac adrenomedullin in this model of hypertension.
authors.affiliation: First Department of Internal Medicine, Miyazaki Medical College, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Ishiyama
authors.forename: K
authors.initials: K
authors.lastname: Kitamura
authors.forename: J
authors.initials: J
authors.lastname: Kato
authors.forename: J
authors.initials: J
authors.lastname: Sakata
authors.forename: K
authors.initials: K
authors.lastname: Kangawa
authors.forename: T
authors.initials: T
authors.lastname: Eto
mesh_terms: D053607:Adrenomedullin; D000818:Animals; D001794:Blood Pressure; D006978:Hypertension, Renovascular / Q000378:metabolism*; D008297:Male; D009206:Myocardium / Q000737:chemistry; D010455:Peptides / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D016277:Ventricular Function, Left
chemical_list: D010455:Peptides; D053607:Adrenomedullin