Responses to alpha 2-adrenoceptor blockade by idazoxan in healthy male and female volunteers.
Seven male and five female volunteers underwent double-blind infusions of the alpha 2-adrenoceptor antagonist idazoxan (100 and 200 micrograms/mg) and placebo in random order. Blood pressure, plasma norepinephrine, growth hormone and subjective responses were measured. The higher dose of idazoxan produced increases in blood pressure, norepinephrine and growth hormone and slight increases in anxiety. Both subject age and sex appeared to influence the magnitude of responses.
Schmidt
M E
ME
Section on Clinical Pharmacology, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA. mschmidt@lilly.com
Risinger
R C
RC
Hauger
R L
RL
Schouten
J L
JL
Henry
M
M
Potter
W Z
WZ
D058669:Adrenergic alpha-2 Receptor Antagonists; D000328:Adult; D001143:Arousal / Q000187:drug effects* / Q000502:physiology; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D019382:Human Growth Hormone / Q000097:blood; D006801:Humans; D019329:Idazoxan / Q000494:pharmacology*; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D009638:Norepinephrine / Q000097:blood; D012737:Sex Factors
D058669:Adrenergic alpha-2 Receptor Antagonists; D019382:Human Growth Hormone; D009638:Norepinephrine; D019329:Idazoxan