Radioiodinated estramustine phosphate and estramustine binding protein antibody accumulate in the prostate of a mouse.
BACKGROUND
The purpose of this study was to determine the distribution of radioiodinated estramustine (RI-EMP) and a radioiodinated antibody against estramustine binding protein (RI-EMBP-AB) in mice.


METHODS
RI-EMP and RI-EMBP-AB were injected in male mice intravenously, and the activities of tissue samples were measured 1-31 hr from the injection. Pure iodine-125 (RI) was used as a control.


RESULTS
RI-EMP accumulated in the prostate, which contained 2.6% of injected activity (ID) per gram tissue at 7 hr. The liver had an activity of 21.4% ID/g at 1 hr, which decreased as RI-EMP was secreted in bile. The lung contained 2.3% ID/g at 7 hr, and it retained the activity longer than the prostate. RI-EMBP-AB accumulated in the prostate: The activity was 2.9% ID/g at 7 hr. The gallbladder contained 6.5% ID/g at 7 hr.


CONCLUSIONS
Due to its cytotoxic and radiosensitizing properties, RI-EMP can possibly be used for treating prostate cancer and other tumors.
Ståhlberg
K
K
Department of Urology, Helsinki University Central Hospital, Finland.
Kairemo
K
K
Karonen
S L
SL
Jekunen
A
A
Taari
K
K
Rannikko
S
S
D000818:Animals; D018931:Antineoplastic Agents, Hormonal / Q000378:metabolism*; D002352:Carrier Proteins / Q000276:immunology*; D002855:Chromatography, Thin Layer; D004961:Estramustine / Q000378:metabolism*; D006207:Half-Life; D007457:Iodine Radioisotopes; D007553:Isotope Labeling; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D011467:Prostate / Q000000981:diagnostic imaging* / Q000378:metabolism*; D029584:Prostatic Secretory Proteins; D011838:Radiation-Sensitizing Agents / Q000378:metabolism*; D011877:Radionuclide Imaging; D014018:Tissue Distribution
D018931:Antineoplastic Agents, Hormonal; D002352:Carrier Proteins; D007457:Iodine Radioisotopes; D029584:Prostatic Secretory Proteins; D011838:Radiation-Sensitizing Agents; C028321:estramustine-binding protein; D004961:Estramustine