Antimicrobial activity of some 13-alkyl substituted protoberberinium salts.
Several 13-alkyl substituted analogs of berberine and palmatine were found to be highly active against two types of Staphylococcus aureus (S1 and S2) of different origin. The most active 13-hexylberberine was 8 times more active (against S1) and the same order active (against S2) as kanamycin sulfate. 13-Hexylpalmatine displayed an activity against S. aureus (S1) 4 times greater than that of kanamycin sulfate. The activities of 13-hexylberberine against two types of S. aureus were 64 and 128 times greater than those of the clinically used alkaloid berberine. Additionally two hexyl derivatives possessed antifungal activity.
Iwasa
K
K
Kobe Pharmaceutical University, Japan.
Kamigauchi
M
M
Sugiura
M
M
Nanba
H
H
D001599:Berberine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology*; D001600:Berberine Alkaloids / Q000737:chemistry / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D013211:Staphylococcus aureus / Q000187:drug effects*; D013329:Structure-Activity Relationship
C583326:13-hexylberberine; D001600:Berberine Alkaloids; D001599:Berberine; C005413:palmatine