[A case of sarcoidosis with proliferative retinopathy].
A 19-year-old female manifested severe bilateral panuveitis with neovascularization in the iris, optic disc, and retina. Fluorescein fundus angiography showed dye leakage from the optic disc and retinal blood vessels, and a large non-perfused area was present in the peripheral retina of the right eye. Sarcoidosis was diagnosed histologically by conjunctival and skin biopsy. Although the patient was given a large dose of a corticosteroid systemically and received panretinal photocoagulation, a dense vitreous hemorrhage and cataract were apparent in the right eye. The right visual acuity decreased to hand motions. A pars plana lensectomy and vitrectomy were performed. After vitrectomy, inflammation and neovascularization regressed and the visual acuity improved to 20/100. Proliferative membrane obtained during vitrectomy was histopathologically studied by light and electron microscopy. Many new vessels containing neutrophils were observed. A direct effect of inflammation as well as ischemia in the retina may have been the stimulus for the proliferative changes.
Miyao
A
A
Machida Hospital, Kochi-ken, Japan.
Hongo
M
M
Uchida
K
K
Machida
T
T
Ikeda
T
T
Matsumoto
Y
Y
Kinoshita
S
S
D000328:Adult; D005260:Female; D006801:Humans; D012164:Retinal Diseases / Q000150:complications* / Q000473:pathology; D015861:Retinal Neovascularization / Q000209:etiology; D012507:Sarcoidosis / Q000150:complications* / Q000473:pathology; D014821:Vitrectomy; D014823:Vitreous Hemorrhage / Q000209:etiology