The NMDA and GABA-A receptors in behavioral activity of rats.
The effects of bicuculline (0.25 mg/kg ip) and AP-7 (5 nmols icv) on the processes of retrieval, consolidation of conditioned reflexes, object recognition and locomotor activity were tested in rats. AP-7, bicuculline and AP-7 with bicuculline increased (but not significantly) locomotor and exploratory activity in the open field test. Only coadministration of AP-7 with bicuculline facilitated retrieval of passive avoidance in rats, but was without effect on consolidation in this test. AP-7 or bicuculline also did not influence on consolidation, when they were given alone. Object recognition was impaired (but not significantly) in groups of rats treated with bicuculline and bicuculline with AP-7.
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Department of Pharmacology, Medical Academy of Białystok, Poland.
Kuziemka-L eska
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Wiśniewski
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D015763:2-Amino-5-phosphonovalerate / Q000031:analogs & derivatives / Q000494:pharmacology; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology*; D001640:Bicuculline / Q000494:pharmacology; D003214:Conditioning, Classical / Q000187:drug effects; D004338:Drug Combinations; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology; D018756:GABA Antagonists / Q000494:pharmacology; D058787:GABA-A Receptor Antagonists; D007276:Injections, Intraventricular; D008297:Male; D011939:Mental Recall / Q000187:drug effects; D009043:Motor Activity / Q000187:drug effects; D010364:Pattern Recognition, Visual / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D011963:Receptors, GABA-A / Q000502:physiology*; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors / Q000502:physiology*
D004338:Drug Combinations; D018691:Excitatory Amino Acid Antagonists; D018756:GABA Antagonists; D058787:GABA-A Receptor Antagonists; D011963:Receptors, GABA-A; D016194:Receptors, N-Methyl-D-Aspartate; D015763:2-Amino-5-phosphonovalerate; C031231:2-amino-7-phosphonoheptanoic acid; D001640:Bicuculline