[Study of disposition of adriamycin and mitomycin C in liver by determination of plasma concentrations in hepatic vein and artery during intravenous constant infusion in rats].
The hepatic extraction ratios (EH) of adriamycin (ADR) and mitomycin C (MMC), which were administered clinically by an intra-hepatic arterial route, were measured in rats to clarify the disposition of ADR and MMC in liver. EH values of ADR and MMC were determined by comparing the femoral arterial and hepatic venous plasma concentrations at steady state during continuous intravenous administration. The EH value of ADR in rats at each infusion rate of 2, 10 and 50 micrograms/kg/min, was 0.290, 0.286 and 0.251, respectively. There was no significant difference between the EH values (p > 0.05). The systemic clearance (CLtot) at each infusion rate was 108, 77.6 and 72.9 ml/min/kg, respectively. The EH value of MMC in rats at each infusion rate of 2.5, 7.5 and 25 micrograms/kg/min, was 0.332, 0.358 and 0.360, respectively. There was no significant difference between the EH values, the same as for ADR. The systemic clearance (CLtot) at each infusion rate was 38.3, 36.1 and 35.3 ml/min/kg.
Fuse
E
E
Pharmaceutical Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.
Takai
K
K
Kobayashi
H
H
Kobayashi
S
S
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000493:pharmacokinetics*; D004317:Doxorubicin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D006499:Hepatic Artery / Q000378:metabolism; D006503:Hepatic Veins / Q000378:metabolism; D007262:Infusions, Intravenous; D008099:Liver / Q000378:metabolism*; D016685:Mitomycin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D051381:Rats
D000903:Antibiotics, Antineoplastic; D016685:Mitomycin; D004317:Doxorubicin