Growth hormone response to the GABAB agonist baclofen in major depressive disorder.
Growth hormone (GH) response to the gamma-aminobutyric acid B receptor agonist, baclofen, was measured in 16 male patients with major depressive disorder and in 16 age-matched healthy male controls. No significant differences were found in the GH response to baclofen between the depressed patients and controls. On repeat testing, the GH response to baclofen showed significant retest reliability in both groups. There was no significant correlation between serum baclofen levels and the GH response to baclofen. Age significantly correlated with GH response, with older subjects having lower GH response to baclofen. These data do not suggest that a blunted GH response to baclofen. represents a specific neuroendocrine feature of major depression.
Davis
L L
LL
Veterans Affairs Medical Center, Dallas, TX 75216, USA. Davis.Lori@Dallas.VA.GOV
Trivedi
M
M
Choate
A
A
Kramer
G L
GL
Petty
F
F
D000328:Adult; D000367:Age Factors; D001418:Baclofen / Q000493:pharmacokinetics; D003866:Depressive Disorder / Q000097:blood / Q000175:diagnosis* / Q000523:psychology; D018755:GABA Agonists / Q000493:pharmacokinetics; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D008875:Middle Aged; D018080:Receptors, GABA-B / Q000187:drug effects*; D012016:Reference Values; D015203:Reproducibility of Results
D018755:GABA Agonists; D018080:Receptors, GABA-B; D001418:Baclofen; D006854:Hydrocortisone