title: Synthesis and pharmacological activities of some 2,3,4,5-tetrahydro[1,5]benzo[f]thiazepines.
abstract: In search of new biological active agents in the series of [1,5]benzothiazepines, some 2,3,4,5-tetrahydro-N-(5-morpholinopentanoyl)-[1,5]benzo[f] thiazepines were synthesized and examined in vitro for their calcium antagonist activity compared to the Diltiazem one.
authors.affiliation: Università degli Studi di Salerno, Facoltà di Farmacia, Penta, Italia.
authors.forename: C
authors.initials: C
authors.lastname: Saturnino
authors.forename: P
authors.initials: P
authors.lastname: Saturnino
authors.forename: G
authors.initials: G
authors.lastname: De Martino
authors.forename: J C
authors.initials: JC
authors.lastname: Lancelot
authors.forename: D
authors.initials: D
authors.lastname: Perrine
authors.forename: S
authors.initials: S
authors.lastname: Rault
authors.forename: M
authors.initials: M
authors.lastname: Robba
authors.forename: F
authors.initials: F
authors.lastname: Rossi
mesh_terms: D000818:Animals; D002121:Calcium Channel Blockers / Q000138:chemical synthesis / Q000494:pharmacology*; D004110:Diltiazem / Q000737:chemistry / Q000494:pharmacology; D005260:Female; D066298:In Vitro Techniques; D008297:Male; D015394:Molecular Structure; D051381:Rats; D017207:Rats, Sprague-Dawley; D013841:Thiazepines / Q000138:chemical synthesis / Q000494:pharmacology*
chemical_list: C106746:1,5-benzothiazepine; D002121:Calcium Channel Blockers; D013841:Thiazepines; D004110:Diltiazem