title: Familial spastic paraplegia: evidence for a fourth locus.
abstract: Autosomal dominant familial spastic paraparesis (AD-FSP) is a genetically heterogeneous disorder of the central nervous system characterized by a progressive spasticity of the legs. One gene causing AD-FSP (FSP1) has recently been mapped to chromosome 14q, another gene (FSP2) to chromosome 2p, and a third gene (FSP3) to chromosome 15q. We now report a large Dutch family with AD-FSP without linkage to any of these chromosomes, providing evidence for a fourth locus (FSP4).
authors.affiliation: Department of Neurology, Oudenryn Hospital, Utrecht, The Netherlands.
authors.forename: R P
authors.initials: RP
authors.lastname: Bruyn
authors.forename: M M
authors.initials: MM
authors.lastname: van Veen
authors.forename: H
authors.initials: H
authors.lastname: Kremer
authors.forename: P H
authors.initials: PH
authors.lastname: Scheltens
authors.forename: G W
authors.initials: GW
authors.lastname: Padberg
mesh_terms: D000328:Adult; D000368:Aged; D002869:Chromosome Aberrations / Q000235:genetics*; D025063:Chromosome Disorders; D002874:Chromosome Mapping; D002883:Chromosomes, Human, Pair 14; D002884:Chromosomes, Human, Pair 15; D002889:Chromosomes, Human, Pair 2; D005260:Female; D005799:Genes, Dominant / Q000235:genetics*; D008040:Genetic Linkage / Q000235:genetics; D006801:Humans; D008297:Male; D018895:Microsatellite Repeats / Q000235:genetics; D008875:Middle Aged; D009426:Netherlands; D010375:Pedigree; D016133:Polymerase Chain Reaction; D015419:Spastic Paraplegia, Hereditary / Q000235:genetics*