The invasion-associated type-III protein secretion system in Salmonella--a review.
The genetic determinants that confer upon Salmonella the ability to enter non-phagocytic cells are largely encoded in a pathogenicity island located at centisome 63 of the bacterial chromosome. Molecular genetic analysis has revealed that this region encodes a specialized protein secretion system that mediates the export and/or translocation of putative signaling proteins into the host cell. This protein secretion system, which has been termed type III or contact-dependent, has also been identified in other plant and animal pathogens that have, in common, the ability to interact with eukaryotic host cells in an intimate manner.
Collazo
C M
CM
Department of Molecular Genetics and Microbiology, School of Medicine, State University of New York at Stony Brook, 11794-5222, USA.
Galán
J E
JE
D001425:Bacterial Outer Membrane Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D001426:Bacterial Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D015964:Gene Expression Regulation, Bacterial; D026901:Membrane Transport Proteins; D006180:Proton-Translocating ATPases / Q000378:metabolism; D012475:Salmonella / Q000235:genetics / Q000378:metabolism / Q000472:pathogenicity*; D012760:Shigella / Q000737:chemistry / Q000378:metabolism; D014158:Transcription, Genetic
D001425:Bacterial Outer Membrane Proteins; D001426:Bacterial Proteins; D026901:Membrane Transport Proteins; C079790:PrgH protein, Salmonella typhimurium; C088598:invC protein, Salmonella typhimurium; C090991:invG protein, Salmonella typhimurium; D006180:Proton-Translocating ATPases