[Impact of prostatic benign hyperplasia and prostatic inflammation on the increase of prostate specific antigen levels].
PSA is currently the best marker in the diagnosis and staging of prostate cancer, although it has a low specificity when trying to distinguish between BPH and prostate cancer. Between January 1994 and December 1995, 243 BPHs were diagnosed after prostate TUR and retropubic adenomectomy. A selection of 131 cases were analyzed based on PSA higher than 4 and normal rectal examination pre-surgery. After surgery PSA was determined again with a time interval from the earlier one ranging between 103-211 days, noting that in about 70% cases PSA levels were normalized and 64% of these also presented focused acute prostatitis, chronic prostatitis, prostate infarction, lithiasis or areas of abscess formation. In spite of a significant number of patients with high PSA levels, this elevation should be interpreted cautiously considering the large percentage of cases where posterior pathological anatomy is a sign of BPH. We believe that among the conditions that could justify such abnormal PSA elevations are those described of areas of chronic or acute prostatitis, prostate infarctions, areas of abscess formation and presence of intraprostate lithiasis.
Ferrero Doria
R
R
Servicio de Urología, Hospital General Universitario de Murcia.
Pérez Flores
D
D
Terrer Artes
C
C
Guzmán Martínez-Valls
P L
PL
Morga Egea
J P
JP
Tomás Ros
M
M
Rico Galiano
J L
JL
Sempere Gutiérrez
A
A
Fontana Compiano
L O
LO
D000368:Aged; D000369:Aged, 80 and over; D006801:Humans; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D011300:Preoperative Care; D017430:Prostate-Specific Antigen / Q000097:blood*; D011469:Prostatic Diseases / Q000097:blood / Q000601:surgery; D011470:Prostatic Hyperplasia / Q000097:blood* / Q000601:surgery; D011472:Prostatitis / Q000097:blood* / Q000601:surgery
D017430:Prostate-Specific Antigen