title: Reduced systemic arterial compliance is associated with left ventricular hypertrophy and diastolic dysfunction in older people.
abstract: OBJECTIVE
  To study the relationship between left ventricular diastolic function and systemic arterial compliance in the older population.
  
  
  METHODS
  Cross-sectional survey.
  
  
  METHODS
  A total of 67 older volunteer participants (aged 67 +/- 5.4 years).
  
  
  METHODS
  Systemic arterial compliance (SAC) was measured using applanation tonometry and aortic velocimetry, and diastolic function was assessed using Doppler filling. Left ventricular mass was determined echocardiographically.
  
  
  RESULTS
  There were significant univariate correlations between diastolic filling, as measured by E/A ratio, systemic arterial compliance (0.34, P < .01), and left ventricular mass (-0.41, P < .001). In multiple regression analysis, using diastolic filling as the dependent variable and heart rate, age, left ventricular mass corrected for body surface area, systolic and diastolic blood pressures, and arterial compliance as independent variables, the major determinants of diastolic filling were heart rate, left ventricular mass, and diastolic blood pressure. Arterial compliance did not make a significant independent contribution.
  
  
  CONCLUSIONS
  This study demonstrates a positive relationship between diastolic filling and arterial compliance in the older population. However, in multiple regression analysis, heart rate, diastolic blood pressure, and left ventricular mass were the independent predictors of diastolic filling (E/A), whereas arterial compliance was not. These findings imply that therapeutic modulation of aortic stiffness would not, of itself, contribute to improvement in diastolic function.
authors.affiliation: Baker Medical Research Institute, Melbourne, Australia.
authors.forename: C
authors.initials: C
authors.lastname: Rajkumar
authors.forename: J D
authors.initials: JD
authors.lastname: Cameron
authors.forename: N
authors.initials: N
authors.lastname: Christophidis
authors.forename: G L
authors.initials: GL
authors.lastname: Jennings
authors.forename: A M
authors.initials: AM
authors.lastname: Dart
mesh_terms: D001158:Arteries / Q000503:physiopathology*; D001783:Blood Flow Velocity; D003187:Compliance; D003971:Diastole; D004452:Echocardiography; D015150:Echocardiography, Doppler; D005260:Female; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000150:complications / Q000000981:diagnostic imaging / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D018487:Ventricular Dysfunction, Left / Q000150:complications / Q000000981:diagnostic imaging / Q000503:physiopathology*