title: [The pathology of labial salivary gland in the diagnosis of Sjogren's syndrome].
abstract: To explore the sensitivity and specificity of the pathology of labial salivary gland in the diagnosis of Sjogren's syndrome (SS) and its specific pathological changes in SS, 100 labial salivary gland specimens were observed and assayed in our hospital. The results indicated that there was no significant difference in acinar atrophy, duct dilatation and lymphocytes infiltration between primary SS (1 degree SS) and secondary SS (2 degrees SS) patients. But those changes had significant difference between 1 degree SS and non-CTD patients (P < 0.01). It was also found in our study that Chisholm grade IV was achieved in 78.57% 1 degree SS specimens, 65.22% 2 degrees SS specimeus and 22.22% in non-CTD specimens, respectively. According to Chisholm standard, the sensitivity and specificity of pathology in the diagnosis of these SS patients was 78.8% and 77.1%. Our patients were still classified by using Chisholm standard. If focal lymphocytes infiltration was used as the single criterion to SS diagnosis, its specificity was not high. In the diagnosis of SS authors should consider the pathologic changes of salivary gland as well as the clinical information in order to avoid misdiagnosis.
authors.affiliation: PUMC Hospital, CAMS, Beijing.
authors.forename: X
authors.initials: X
authors.lastname: Li
authors.forename: Z
authors.initials: Z
authors.lastname: Wen
mesh_terms: D006801:Humans; D008046:Lip / Q000473:pathology; D012469:Salivary Glands / Q000473:pathology*; D012680:Sensitivity and Specificity; D012859:Sjogren's Syndrome / Q000473:pathology*