title: Protective effect of curcuminoids on epidermal skin cells under free oxygen radical stress.
abstract: Curcuminoids from Curcuma longa L. (Zingiberaceae) protected normal human keratinocytes from hypoxanthine/ xanthine oxidase injury. Since curcuminoids synergistically inhibited nitroblue tetrazolium reduction, a decrease in superoxide radical formation leading to lower levels of cytotoxic hydrogen peroxide was proposed as an explanation for this protective effect.
authors.forename: F
authors.initials: F
authors.lastname: Bonté
authors.forename: M S
authors.initials: MS
authors.lastname: Noel-Hudson
authors.forename: J
authors.initials: J
authors.lastname: Wepierre
authors.forename: A
authors.initials: A
authors.lastname: Meybeck
mesh_terms: D000975:Antioxidants; D002455:Cell Division / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D003474:Curcumin / Q000031:analogs & derivatives* / Q000494:pharmacology*; D000078404:Epidermal Cells; D006801:Humans; D007231:Infant, Newborn; D015603:Keratinocytes / Q000166:cytology / Q000187:drug effects* / Q000502:physiology; D008297:Male; D018384:Oxidative Stress; D012867:Skin / Q000166:cytology*; D017365:Spices; D013481:Superoxides / Q000378:metabolism
chemical_list: D000975:Antioxidants; D013481:Superoxides; D003474:Curcumin