Inhibitory effects of seven organosulphur compounds on clinical isolates of Candida species in vitro.
Thirty clinical isolates of Candida albicans and 10 other Candida species were tested for susceptibility to 6 substituted dithiocarbamates and one dimercaptosuccinate. Dimethyldithiocarbamate, sodium pyrrolidine dithiocarbamate, and sodium diethyldithiocarbamate showed dose-dependent antifungal activity which was partially reversed by the addition of zinc, copper, or iron sulfate with greatest reversal at 2:1 metal to dithiocarbamate molar ratio. Anaerobiosis also interfered with dithiocarbamate antifungal activity.
Shah
D T
DT
Department of Pathology, Marshall University School of Medicine, Huntington, WV 25705, USA.
Walker
E M
EM
Jones
M M
MM
Singh
P K
PK
Larsen
B
B
D000693:Anaerobiosis / Q000502:physiology; D000935:Antifungal Agents / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects* / Q000254:growth & development*; D002176:Candida albicans / Q000187:drug effects* / Q000254:growth & development*; D003300:Copper / Q000494:pharmacology; D004221:Disulfiram / Q000031:analogs & derivatives / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D007501:Iron / Q000494:pharmacology; D019216:Metals, Heavy / Q000494:pharmacology; D009942:Organometallic Compounds / Q000494:pharmacology*; D004113:Succimer / Q000494:pharmacology; D013455:Sulfur / Q000494:pharmacology*; D013859:Thiocarbamates / Q000494:pharmacology; D015032:Zinc / Q000494:pharmacology
D000935:Antifungal Agents; D019216:Metals, Heavy; D009942:Organometallic Compounds; D013859:Thiocarbamates; D013455:Sulfur; D003300:Copper; D004113:Succimer; D007501:Iron; D015032:Zinc; D004221:Disulfiram