[Effects of processing on specific toxicity and pharmacodynamics of radix Kansui, radix Achyranthis bidentatae and semen Armeniacae amarum].
The comparative toxicological researches on crude and processed drugs show that the activating action of Radix Kansui, Radix Achyranthis Bidentatae and Semen Armeniacae Amarum on EBV-EA can be decreased by processing. Processing can also decrease stimulating activity on mouse skin, inhibit tumor-promoting activity in two stage skin tumor promoting test and lapactic effect by Radix Kansui. Meanwhile the pharmacological effects of these drugs can be retained or increased by processing.
Nie
S
S
Institute of Chinese Materia Medica, China Academy of Traditional Chinese Medicine, Beijing.
Li
Z
Z
Liang
A
A
Xue
B
B
Li
G
G
Wang
X
X
D000818:Animals; D000956:Antigens, Viral / Q000187:drug effects*; D002400:Cathartics / Q000633:toxicity; D002869:Chromosome Aberrations; D004232:Diuretics / Q000633:toxicity; D004365:Drugs, Chinese Herbal / Q000494:pharmacology / Q000633:toxicity*; D005260:Female; D006358:Hot Temperature; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D015162:Micronucleus Tests
D000956:Antigens, Viral; D002400:Cathartics; D004232:Diuretics; D004365:Drugs, Chinese Herbal; C033305:Epstein-Barr virus early antigen