[The neurophysiological effects of the beta-blocker obzidan in the modelling of emotional stress].
Neurophysiological effects of beta-blocker obsidan have been studied in experiments with 3 month old male Wistar rats under conditions of modelling of emotional disturbances. It is shown that the 7-8 day stress induced profound changes in electrographic, emotional and vegetation reactions of rats. Disturbances induced by the stress are observed for a long-term poststress period. Controlling and normalizing the level of excitability of the cortex-subcortex structures the beta-blocker obsidan promotes reversibility of the stress-induced changes. Central beta-adrenoreactive systems of the brain play the important role in mechanisms of formation of stress states and their consequences.
Shever'ova
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VM
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000503:physiopathology; D004195:Disease Models, Animal; D004644:Emotions / Q000187:drug effects / Q000502:physiology; D008297:Male; D011433:Propranolol / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013315:Stress, Psychological / Q000503:physiopathology*; D013997:Time Factors
D000319:Adrenergic beta-Antagonists; D011433:Propranolol