title: Superficial necrolytic dermatitis and a pancreatic endocrine tumour in a dog.
abstract: A 13-year-old dog was referred for a severe dermatological problem of 12 months duration. Skin biopsy results were compatible with superficial necrolytic dermatitis. The only laboratory abnormalities were hyperglycaemia and hyperglucagonaemia. These findings suggested a pancreatic endocrine tumour in association with superficial necrolytic dermatitis. Abdominal ultrasound examination was unremarkable. The dog was euthanased due to the lack of clinical improvement following symptomatic therapy. Postmortem examination revealed a pancreatic endocrine tumour with liver metastases. Pancreatic endocrine tumour cells were immunoreactive for glucagon, insulin and islet amyloid polypeptide.
authors.affiliation: Department of Small Animal Clinical Sciences, University of Minnesota, St Paul 55108, USA.
authors.forename: S
authors.initials: S
authors.lastname: Torres
authors.forename: K
authors.initials: K
authors.lastname: Johnson
authors.forename: P
authors.initials: P
authors.lastname: McKeever
authors.forename: R
authors.initials: R
authors.lastname: Hardy
mesh_terms: D000682:Amyloid / Q000032:analysis; D000818:Animals; D001706:Biopsy / Q000379:methods / Q000662:veterinary; D001786:Blood Glucose / Q000032:analysis; D003872:Dermatitis / Q000150:complications / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*; D004283:Dog Diseases / Q000097:blood / Q000175:diagnosis* / Q000473:pathology; D004285:Dogs; D005934:Glucagon / Q000032:analysis / Q000097:blood; D007150:Immunohistochemistry / Q000379:methods; D007328:Insulin / Q000032:analysis; D058228:Islet Amyloid Polypeptide; D008099:Liver / Q000737:chemistry / Q000473:pathology; D008113:Liver Neoplasms / Q000175:diagnosis / Q000556:secondary / Q000662:veterinary; D008297:Male; D009336:Necrosis; D010179:Pancreas / Q000737:chemistry / Q000473:pathology; D010190:Pancreatic Neoplasms / Q000150:complications / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*
chemical_list: D000682:Amyloid; D001786:Blood Glucose; D007328:Insulin; D058228:Islet Amyloid Polypeptide; D005934:Glucagon