title: Kaposi's sarcoma-associated herpesvirus and human herpesvirus 8 (KSHV/HHV8)-associated lymphoma of the bowel. Report of two cases in HIV-positive men with secondary effusion lymphomas.
abstract: This report describes two cases of Kaposi's sarcoma-associated herpesvirus/human herpesvirus-8 (KSHV/HHV8)-associated lymphomas that primarily involved the large bowel and that secondarily caused malignant effusions. Involvement of the gastrointestinal tract is of interest because epidemiologic evidence suggests that KSHV/HHV-8 may be transmitted via the fecal-oral route, and KSHV/HHV8 DNA has been detected in rectal samples from HIV-positive patients. This report describes two HIV-positive men who developed primary KSHV/ HHV8-associated lymphomas of the bowel. Despite similar morphology and immunophenotype, these cases differ from most KSHV/HHV8-associated primary effusion lymphomas, which present with malignant effusions in the absence of a solid tumor mass. The spectrum of KSHV/HHV8-associated lymphomas is expanded to include a subset of primary bowel lymphomas in individuals infected with human immunodeficiency virus.
authors.affiliation: Department of Pathology, Truman Medical Center, Kansas City, Missouri, USA.
authors.forename: W
authors.initials: W
authors.lastname: DePond
authors.forename: J W
authors.initials: JW
authors.lastname: Said
authors.forename: T
authors.initials: T
authors.lastname: Tasaka
authors.forename: S
authors.initials: S
authors.lastname: de Vos
authors.forename: D
authors.initials: D
authors.lastname: Kahn
authors.forename: E
authors.initials: E
authors.lastname: Cesarman
authors.forename: D M
authors.initials: DM
authors.lastname: Knowles
authors.forename: H P
authors.initials: HP
authors.lastname: Koeffler
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000635:transmission / Q000821:virology*; D000328:Adult; D001706:Biopsy; D018562:Disease Transmission, Infectious; D006679:HIV Seropositivity / Q000150:complications*; D019288:Herpesvirus 8, Human / Q000302:isolation & purification*; D006801:Humans; D016130:Immunophenotyping; D007413:Intestinal Mucosa / Q000821:virology*; D008223:Lymphoma / Q000473:pathology* / Q000821:virology; D008297:Male; D012514:Sarcoma, Kaposi / Q000473:pathology* / Q000821:virology