Isolation and characterization of an acetylated impurity in Escherichia coli-derived recombinant human interleukin-10 (IL-10) drug substance.
Pflumm
M N
MN
Schering-Plough Research Institute, Kenilworth, New Jersey 07033, USA.
Gruber
S C
SC
Tsarbopoulos
A
A
Wylie
D
D
Pramanik
B
B
Bausch
J N
JN
Patel
S T
ST
D002851:Chromatography, High Pressure Liquid; D004340:Drug Contamination; D004926:Escherichia coli / Q000737:chemistry*; D006801:Humans; D016753:Interleukin-10 / Q000737:chemistry*; D008239:Lysine / Q000031:analogs & derivatives* / Q000302:isolation & purification; D013058:Mass Spectrometry; D011994:Recombinant Proteins / Q000737:chemistry
D011994:Recombinant Proteins; D016753:Interleukin-10; C016949:N-epsilon-acetyllysine; D008239:Lysine