title: [Total intravenous anesthesia with propofol in orthotopic liver transplantation in swine].
abstract: OBJECTIVE
  To study the use of total intravenous anesthesia with propofol as an anesthetic model for orthotopic liver transplantation (OLT) in pigs. ANIMALS AND METHOD: Fifteen OLT were performed in pigs using portacava-jugular veno-venous shunt with an injector pump. Anesthesia was maintained by perfusion of 10 mg/kg/h propofol. Hemodynamic and biochemical measurements were recorded at the following times: AO, baseline; AI, five minutes before removal of the liver; B1, five minutes later but before starting the bypass injector pump; B2, five minutes after starting the injector pump; B3, five minutes before reperfusion; C1, five minutes after starting reperfusion, and C2, after aortic declamping.
  
  
  RESULTS
  No cases of malignant hyperthermia appeared. When the liver was removed cardiac output decreased (p < 0.01), as did mean arterial pressure (p < 0.01), mixed venous saturation (p < 0.05), pulmonary capillary pressure and temperature (p < 0.05). Pulmonary vascular resistances increased (p < 0.05).
  
  
  CONCLUSIONS
  The use of total intravenous anesthesia with propofol is a satisfactory experimental anesthetic model for OLT in pigs, and it prevents the possible appearance of malignant hyperthermia.
authors.affiliation: Unidad Experimental, Ciudad Sanitaria Virgen de las Nieves, Granada.
authors.forename: A
authors.initials: A
authors.lastname: Ramírez
authors.forename: M
authors.initials: M
authors.lastname: Martínez
authors.forename: J
authors.initials: J
authors.lastname: Jiménez
authors.forename: D
authors.initials: D
authors.lastname: Garrote
authors.forename: M A
authors.initials: MA
authors.lastname: Cabrera
authors.forename: J
authors.initials: J
authors.lastname: Villar
authors.forename: J A
authors.initials: JA
authors.lastname: Ferrón
mesh_terms: D000768:Anesthesia, General; D000771:Anesthesia, Intravenous; D018686:Anesthetics, Intravenous; D000818:Animals; D005260:Female; D016031:Liver Transplantation; D015742:Propofol; D013552:Swine
chemical_list: D018686:Anesthetics, Intravenous; D015742:Propofol