Protective effect of curcuminoids on epidermal skin cells under free oxygen radical stress.
Curcuminoids from Curcuma longa L. (Zingiberaceae) protected normal human keratinocytes from hypoxanthine/ xanthine oxidase injury. Since curcuminoids synergistically inhibited nitroblue tetrazolium reduction, a decrease in superoxide radical formation leading to lower levels of cytotoxic hydrogen peroxide was proposed as an explanation for this protective effect.
Bonté
F
F
Noel-Hudson
M S
MS
Wepierre
J
J
Meybeck
A
A
D000975:Antioxidants; D002455:Cell Division / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D003474:Curcumin / Q000031:analogs & derivatives* / Q000494:pharmacology*; D000078404:Epidermal Cells; D006801:Humans; D007231:Infant, Newborn; D015603:Keratinocytes / Q000166:cytology / Q000187:drug effects* / Q000502:physiology; D008297:Male; D018384:Oxidative Stress; D012867:Skin / Q000166:cytology*; D017365:Spices; D013481:Superoxides / Q000378:metabolism
D000975:Antioxidants; D013481:Superoxides; D003474:Curcumin