[The effect of a new hypolipemic preparation fluvastatin (Lescol) on rheological indices and hemostatic parameters].
In view of inducing action of hyperlipidemia on progression of nephropathy and relationships between thrombogenesis, atherogenesis and sclerosis, the authors examined fluvastatin effects on platelet-rheological hemostasis. The 12-week course in a dose 20-40 mg/ day produced minimal side effects while its hypolipidemic action was noticeable: a 18, 21 and 20% fall in concentrations of total cholesterol, LDL cholesterol, triglycerides, respectively. The platelet rheology underwent the following changes: spontaneous platelet aggregation went down from 2.58 +/- 0.3 to 1.64 +/- 0.27 r.units, ADP-induced platelet aggregation rose from 6.5 +/- 0.66 to 8.08 +/- 0.77 r.units. No marked changes were registered in hematocrit, plasma and blood density, red cell aggregation and deformability. Thus, active lowering of blood lipids was not associated with evident inhibition of platelet activity. The absence of this feedback in lipid-platelet relations probably indicates an independent significance of hemostatic disturbances in ischemic heart disease and needs further study.
Filippova
V G
VG
Mantsurova
A V
AV
Zadionchenko
V S
VS
Zaporozhets
T P
TP
D004341:Drug Evaluation; D004907:Erythrocyte Deformability / Q000187:drug effects; D005229:Fatty Acids, Monounsaturated / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D000077340:Fluvastatin; D018056:Hemorheology / Q000187:drug effects*; D006487:Hemostasis / Q000187:drug effects*; D006801:Humans; D000960:Hypolipidemic Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D007211:Indoles / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D008055:Lipids / Q000097:blood; D017202:Myocardial Ischemia / Q000097:blood / Q000188:drug therapy; D010974:Platelet Aggregation / Q000187:drug effects; D013997:Time Factors
D005229:Fatty Acids, Monounsaturated; D000960:Hypolipidemic Agents; D007211:Indoles; D008055:Lipids; D000077340:Fluvastatin