title: Identification and characterization of second-generation antisense oligonucleotides.
authors.affiliation: ISIS Pharmaceuticals, Carlsbad, CA 92008, USA.
authors.forename: N M
authors.initials: NM
authors.lastname: Dean
authors.forename: R H
authors.initials: RH
authors.lastname: Griffey
mesh_terms: D015195:Drug Design; D005786:Gene Expression Regulation / Q000187:drug effects; D015394:Molecular Structure; D016376:Oligonucleotides, Antisense / Q000737:chemistry* / Q000494:pharmacology; D011687:Purines / Q000737:chemistry; D011743:Pyrimidines / Q000737:chemistry; D013329:Structure-Activity Relationship; D013873:Thionucleotides / Q000737:chemistry / Q000494:pharmacology
chemical_list: D016376:Oligonucleotides, Antisense; D011687:Purines; D011743:Pyrimidines; D013873:Thionucleotides