title: [Clinical evaluation of heparin concentration and activated clotting time monitoring (HEPCON HMS) system].
abstract: The HEPCON HMS system provides both activated clotting time (ACT) and accurate whole blood heparin concentration measurements. We evaluated the impact of heparin and protamine administration using this system on the incidence and treatment of bleeding after performing a cardiopulmonary bypass. Patients were randomly divided into two groups. Heparin and protamine administration during extracorporeal circulation was determined by classical ACT management in Group A (n = 15) and by HEPCON HMS system in Group H (n = 19). There were no statistical differences in the coagulation factor, the postoperative chest tube drainage or the blood products used between the two groups. Patients in Group H received a higher dosage of heparin and a lower dosage of protamine compared with Group A. By facilitating the maintenance of a therapeutic heparin concentration and by determining an appropriate protamine dosage, the HEPCON HMS system may be useful in managing extracorporeal circulation.
authors.affiliation: Department of Thoracic and Cardiovascular Surgery, National Obihiro Hospital, Hokkaido, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Sakurada
authors.forename: Y
authors.initials: Y
authors.lastname: Kikuchi
authors.forename: R
authors.initials: R
authors.lastname: Koushima
authors.forename: S
authors.initials: S
authors.lastname: Nakashima
authors.forename: Y
authors.initials: Y
authors.lastname: Hachiro
authors.forename: H
authors.initials: H
authors.lastname: Kagaya
mesh_terms: D001780:Blood Coagulation Tests / Q000295:instrumentation*; D005112:Extracorporeal Circulation; D005260:Female; D006493:Heparin / Q000008:administration & dosage / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016343:Monitoring, Intraoperative / Q000295:instrumentation*; D011479:Protamines / Q000008:administration & dosage
chemical_list: D011479:Protamines; D006493:Heparin