Effects of nerve growth factor on acetylcholinesterase activity of the proximal stump of the transected sciatic nerve.
28 rats were studied. They were divided into four groups of 7 rats of each one-day control animals (Group A), seven-day control animals (Group B), one-day nerve growth factor (NGF)-treated animals (Group C) and seven-day NGF-treated animals (Group D). In all animals, the right sciatic nerve was explored and completely transected using microscissors under a microscope. In NGF-treated animals, NGF (0.1 mg/kg NGF) was injected subcutaneously. In control animals, there was a statistically significant decrease in AChE activity in the proximal stump of the transected sciatic nerve at 7-day measurements (p < 0.05). In the NGF-treated groups, mean AChE activity in the proximal stump of the transected sciatic nerve was decreased at the 7-day measurement. AChE activity difference between control and NGF-treated groups, measured on the 7th day, are statistically significant (p < 0.01). These results demonstrate the effect of NGF on the cholinergic system.
Baykal
S
S
KTU Medical Faculty, Department of Neurosurgery, Trabzon-Turkey.
Usul
H
H
Aliyacioğlu
Y
Y
Efe
H
H
Duru
S
S
D000110:Acetylcholinesterase / Q000378:metabolism*; D000818:Animals; D004334:Drug Administration Schedule; D007279:Injections, Subcutaneous; D009414:Nerve Growth Factors / Q000494:pharmacology*; D009416:Nerve Regeneration / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D012584:Sciatic Nerve / Q000187:drug effects*
D009414:Nerve Growth Factors; D000110:Acetylcholinesterase