title: Seroepidemiologic studies of hantavirus infection among wild rodents in California.
abstract: A total of 4,626 mammals were serologically tested for antibodies to Sin Nombre virus. All nonrodent species were antibody negative. Among wild rodents, antibody prevalence was 8.5% in murids, 1.4% in heteromyids, and < 0.1% in sciurids. Of 1,921 Peromyscus maniculatus (deer mice), 226 (11.8%) were antibody positive, including one collected in 1975. The highest antibody prevalence (71.4% of 35) was found among P. maniculatus on Santa Cruz Island, off the southern California coast. Prevalence of antibodies among deer mice trapped near sites of human cases (26.8% of 164) was significantly higher than that of mice from other sites (odds ratio = 4.5; 95% confidence interval = 1.7, 11.6). Antibody prevalence increased with rising elevation (> 1,200 meters) and correlated with a spatial cluster of hantavirus pulmonary syndrome cases in the Sierra Nevada.
authors.affiliation: California Department of Health Services, Sacramento, USA.
authors.forename: M
authors.initials: M
authors.lastname: Jay
authors.forename: M S
authors.initials: MS
authors.lastname: Ascher
authors.forename: B B
authors.initials: BB
authors.lastname: Chomel
authors.forename: M
authors.initials: M
authors.lastname: Madon
authors.forename: D
authors.initials: D
authors.lastname: Sesline
authors.forename: B A
authors.initials: BA
authors.lastname: Enge
authors.forename: B
authors.initials: B
authors.lastname: Hjelle
authors.forename: T G
authors.initials: TG
authors.lastname: Ksiazek
authors.forename: P E
authors.initials: PE
authors.lastname: Rollin
authors.forename: P H
authors.initials: PH
authors.lastname: Kass
authors.forename: K
authors.initials: K
authors.lastname: Reilly
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000097:blood*; D002140:California / Q000453:epidemiology; D006476:Orthohantavirus / Q000276:immunology; D018778:Hantavirus Infections / Q000453:epidemiology / Q000662:veterinary*; D006801:Humans; D010542:Peromyscus; D012376:Rodent Diseases / Q000453:epidemiology*
chemical_list: D000914:Antibodies, Viral