title: N,O-bisFmoc derivatives of N-(2-hydroxy-4-methoxybenzyl)-amino acids: useful intermediates in peptide synthesis.
abstract: 2-Hydroxy-4-methoxybenzyl-amino acid residues inhibit interchain association in solid phase peptide synthesis. They are easily introduced through their N,O-bisFmoc derivatives. Preparation of a range of these derivatives is described.
authors.affiliation: MRC Laboratory of Molecular Biology, Cambridge, UK.
authors.forename: T
authors.initials: T
authors.lastname: Johnson
authors.forename: M
authors.initials: M
authors.lastname: Quibell
authors.forename: R C
authors.initials: RC
authors.lastname: Sheppard
mesh_terms: D000595:Amino Acid Sequence; D000596:Amino Acids / Q000737:chemistry; D015195:Drug Design; D005449:Fluorenes / Q000737:chemistry; D008722:Methods; D015394:Molecular Structure; D009842:Oligopeptides / Q000138:chemical synthesis / Q000737:chemistry; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000596:Amino Acids; D005449:Fluorenes; D009842:Oligopeptides; D010455:Peptides