title: Oral 18F-fluoro-2-deoxyglucose for primate PET studies without behavioral restraint: demonstration of principle.
abstract: We describe a method of orally administering 18F-fluoro-2-deoxyglucose (FDG) for positron emission tomography (PET) scans to determine local cerebral metabolic rates for glucose (LCMRGlc), normalized to that of whole brain, in fully conscious, non-restrained primates. Oral FDG-PET studies were performed in both non-restrained and chaired monkeys, and in one human where results could be compared with traditional intravenous FDG administration. The oral route of FDG administration gave images and whole brain-normalized PET LCMRGlc results comparable to those obtained by the intravenous route. This oral FDG-PET method may provide a useful means by which to obtain measures of LCMRGlcs for brain structures, relative to each other, in non-restrained, non-drugged primates in field and laboratory studies. This method might also have clinical applications for PET studies of children.
authors.affiliation: Department of Psychiatry and Biobehavioral Sciences, UCLA School of Medicine, USA.
authors.forename: Z A
authors.initials: ZA
authors.lastname: Martinez
authors.forename: M
authors.initials: M
authors.lastname: Colgan
authors.forename: L R
authors.initials: LR
authors.lastname: Baxter
authors.forename: J
authors.initials: J
authors.lastname: Quintana
authors.forename: S
authors.initials: S
authors.lastname: Siegel
authors.forename: A
authors.initials: A
authors.lastname: Chatziioannou
authors.forename: S R
authors.initials: SR
authors.lastname: Cherry
authors.forename: J C
authors.initials: JC
authors.lastname: Mazziotta
authors.forename: M E
authors.initials: ME
authors.lastname: Phelps
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism*; D003847:Deoxyglucose / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D005260:Female; D005462:Fluorine Radioisotopes / Q000008:administration & dosage / Q000493:pharmacokinetics; D019788:Fluorodeoxyglucose F18; D005947:Glucose / Q000378:metabolism*; D007275:Injections, Intravenous; D008253:Macaca mulatta; D008297:Male; D013997:Time Factors; D014018:Tissue Distribution; D014055:Tomography, Emission-Computed / Q000379:methods / Q000662:veterinary*
chemical_list: D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D003847:Deoxyglucose; D005947:Glucose