title: Granulosa cell tumor of the ovary associated with antecedent tamoxifen use.
abstract: BACKGROUND
  Increased attention has been focused recently on the estrogenic effects of tamoxifen. Review of the literature reveals an association between tamoxifen use and gynecologic tumors.
  
  
  METHODS
  A 52-year-old postmenopausal woman was treated with tamoxifen for stage II estrogen receptor-positive breast carcinoma. Her aspartate transaminase and alanine transaminase levels increase markedly after 6 months of tamoxifen use. After an additional 17 months of elevated serum transaminases, the patient was found to have a stage Ic granulosa cell tumor of the ovary.
  
  
  CONCLUSIONS
  Patients with tamoxifen-induced liver dysfunction may be at increased risk for granulosa cell tumors because of alterations in tamoxifen metabolism.
authors.affiliation: Department of Obstetrics and Gynecology, Bethesda Naval Hospital, National Naval Medical Center, Bethesda, Maryland, USA.
authors.forename: R B
authors.initials: RB
authors.lastname: Gherman
authors.forename: M F
authors.initials: MF
authors.lastname: Parker
authors.forename: C I
authors.initials: CI
authors.lastname: Macri
mesh_terms: D018931:Antineoplastic Agents, Hormonal / Q000009:adverse effects*; D001943:Breast Neoplasms / Q000188:drug therapy*; D005260:Female; D006106:Granulosa Cell Tumor / Q000139:chemically induced*; D006801:Humans; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000139:chemically induced*; D010051:Ovarian Neoplasms / Q000139:chemically induced*; D013629:Tamoxifen / Q000009:adverse effects*
chemical_list: D018931:Antineoplastic Agents, Hormonal; D013629:Tamoxifen