title: [Fertilization in vitro and embryo transfer by combined long-acting gonadotropin releasing hormone agonist and gonadotropin for superovulation in patients with refractory polycystic ovary syndrome].
abstract: OBJECTIVE
  To investigate the efficacy of the treatment for polycystic ovary syndrome (PCOS) patients by combined long acting gonadotropin-releasing hormone agonist (GnRHa) and gonadotropin.
  
  
  METHODS
  Nineteen women with PCOS who had failed to conceive on treatment with conventional fertilization in vitro-embryo transfer (IVF-ET) protocol underwent 26 cycles of IVF-ET by combined long-acting and gonadotropin stimulation. A self-control group consisted of 19 PCOS women who had received 19 treatment cycles with conventional IVF-ET stimulation protocol more than 6 months previously.
  
  
  RESULTS
  A comparison of these two groups showed that treatment with combined long-acting GnRHa and gonadotropin improved the in vitro fertility rate (76.2%) and pregnancy rate (38.5%).
  
  
  CONCLUSIONS
  Patients with refractory PCOS should be referred for IVF-ET, using long-acting GnRHa before gonadotropin as the stimulation protocol.
authors.affiliation: First Affiliated Hospital of Sun Yet-Sen University of Medical Sciences, Guangzhou.
authors.forename: R
authors.initials: R
authors.lastname: Li
authors.forename: G
authors.initials: G
authors.lastname: Zhuang
authors.forename: C
authors.initials: C
authors.lastname: Zhou
mesh_terms: D000328:Adult; D003692:Delayed-Action Preparations; D004359:Drug Therapy, Combination; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro; D007987:Gonadotropin-Releasing Hormone / Q000819:agonists* / Q000627:therapeutic use; D006062:Gonadotropins / Q000627:therapeutic use*; D006801:Humans; D011085:Polycystic Ovary Syndrome / Q000188:drug therapy*; D013480:Superovulation; D017329:Triptorelin Pamoate / Q000627:therapeutic use*
chemical_list: D003692:Delayed-Action Preparations; D006062:Gonadotropins; D017329:Triptorelin Pamoate; D007987:Gonadotropin-Releasing Hormone