title: Renal angiotensin-converting enzyme localization in diabetic rats and the effect of low protein diet.
abstract: Recent evidence suggests a role of angiotensin-converting enzyme (ACE) in diabetic nephropathy. The effect of diabetes and low protein diet on renal immunohistochemical ACE localization was studied in streptozotocin-induced DM rats. Immunohistochemical ACE localization was reduced in DM rats, and a low protein diet partially resolved this abnormality while inhibiting the progression of diabetic nephropathy.
authors.affiliation: Department of Nephrology, Toho University School of Medicine, Ohta-ku Tokyo, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Mizuiri
authors.forename: M
authors.initials: M
authors.lastname: Kobayashi
authors.forename: T
authors.initials: T
authors.lastname: Nakanishi
authors.forename: H
authors.initials: H
authors.lastname: Yoshikawa
authors.forename: M
authors.initials: M
authors.lastname: Miyagi
authors.forename: M
authors.initials: M
authors.lastname: Tanegashima
authors.forename: K
authors.initials: K
authors.lastname: Sakai
authors.forename: I
authors.initials: I
authors.lastname: Hayashi
authors.forename: T
authors.initials: T
authors.lastname: Fushimi
authors.forename: A
authors.initials: A
authors.lastname: Hasegawa
mesh_terms: D000419:Albuminuria; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure; D003921:Diabetes Mellitus, Experimental / Q000201:enzymology* / Q000473:pathology / Q000503:physiopathology; D003928:Diabetic Nephropathies / Q000201:enzymology* / Q000473:pathology / Q000517:prevention & control*; D018753:Diet, Protein-Restricted; D007150:Immunohistochemistry; D007668:Kidney / Q000201:enzymology* / Q000473:pathology; D008297:Male; D007703:Peptidyl-Dipeptidase A / Q000032:analysis*; D051381:Rats; D017208:Rats, Wistar; D012709:Serum Albumin / Q000378:metabolism; D013997:Time Factors
chemical_list: D001786:Blood Glucose; D012709:Serum Albumin; D007703:Peptidyl-Dipeptidase A