title: Homoserine O-acetyltransferase, involved in the Leptospira meyeri methionine biosynthetic pathway, is not feedback inhibited.
abstract: The Leptospira meyeri serovar semaranga metX gene was identified by complementation of an Escherichia coli metA mutant, i.e., devoid of homoserine O-succinyltransferase. However, the MetX protein exhibited a homoserine O-acetyltransferase activity in agreement with its similarity to homoserine O-acetyltransferases. Reverse transcription-PCR analysis demonstrated that metX is the second gene of an operon.
authors.affiliation: Unité de Bacteriologie Moleculaire et Mf1edicale, Institut Pasteur, Paris, France.
authors.forename: P
authors.initials: P
authors.lastname: Bourhy
authors.forename: A
authors.initials: A
authors.lastname: Martel
authors.forename: D
authors.initials: D
authors.lastname: Margarita
authors.forename: I
authors.initials: I
authors.lastname: Saint Girons
authors.forename: J
authors.initials: J
authors.lastname: Belfaiza
mesh_terms: D000123:Acetyltransferases / Q000235:genetics* / Q000378:metabolism; D000217:Acyltransferases / Q000235:genetics; D000595:Amino Acid Sequence; D001426:Bacterial Proteins / Q000235:genetics* / Q000378:metabolism; D001483:Base Sequence; D003001:Cloning, Molecular; D004269:DNA, Bacterial; D005816:Genetic Complementation Test; D051082:Homoserine O-Succinyltransferase; D007919:Leptospira / Q000201:enzymology* / Q000235:genetics; D008715:Methionine / Q000096:biosynthesis*; D008969:Molecular Sequence Data; D009876:Operon; D017386:Sequence Homology, Amino Acid
chemical_list: D001426:Bacterial Proteins; D004269:DNA, Bacterial; D008715:Methionine; D000217:Acyltransferases; D000123:Acetyltransferases; C021369:homoserine O-acetyltransferase; D051082:Homoserine O-Succinyltransferase