Bacterial resistance to aminoglycoside antibiotics.
The aminoglycoside antibiotics are broad-spectrum antibacterial compounds that are used extensively for the treatment of many bacterial infections. In view of the current concerns over the global rise in antibiotic-resistant microorganisms, there has been renewed interest in the mechanisms of resistance to the aminoglycosides, including the superfamily of aminoglycoside-modifying enzymes.
Davies
J
J
Dept of Microbiology and Immunology, University of British Columbia, Vancouver, Canada. jed@unixg.ubc.ca
Wright
G D
GD
D000123:Acetyltransferases / Q000235:genetics / Q000378:metabolism; D000595:Amino Acid Sequence; D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D002240:Carbohydrate Sequence; D004352:Drug Resistance, Microbial / Q000235:genetics; D008969:Molecular Sequence Data; D015394:Molecular Structure; D009161:Mycobacterium; D009713:Nucleotidyltransferases / Q000235:genetics / Q000378:metabolism; D010770:Phosphotransferases / Q000235:genetics / Q000378:metabolism; D017853:Phosphotransferases (Alcohol Group Acceptor) / Q000235:genetics; D013302:Streptomyces / Q000235:genetics
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D000123:Acetyltransferases; D010770:Phosphotransferases; D017853:Phosphotransferases (Alcohol Group Acceptor); C022680:streptomycin 6-kinase; D009713:Nucleotidyltransferases; C061037:aminoglycoside 6-adenylyltransferase