Cardiovascular risk factor profile in subjects with familial predisposition to myocardial infarction in Denmark.
OBJECTIVE
To identify possible modifiable mediators of familial predisposition to myocardial infarction (MI) by assessing the risk factor profile in individuals without MI in relation to parental occurrence of MI.


METHODS
Cross sectional survey of the general population. The odds of an adverse cardiovascular risk factor profile in subjects reporting parental occurrence of MI versus subjects not reporting parental occurrence were estimated by logistic regression models.


METHODS
The Copenhagen Centre for Prospective Population Studies, where subjects investigated in three Danish prospective population studies are integrated.


METHODS
Subjects were 9306 females and 11,091 males aged 20-75 years with no history of MI. A total of 1370 subjects reported maternal MI and 2583 reported paternal MI.


RESULTS
Increased systolic and diastolic blood pressure, increased cholesterol level, low ratio between high density lipoprotein (HDL) and total cholesterol (TC), and heavy smoking, were more frequent in subjects with parental occurrence of MI than in controls irrespective of sex and age of the subjects. Maternal MI was more predictive for increased cholesterol and decreased HDL/ TC ratio than paternal MI, and the risk of an increased cholesterol level was higher in subjects aged 20-39 years than in older subjects. No differences in body mass index, triglycerides, and physical inactivity were observed.


CONCLUSIONS
Subjects free of previous MI who reported a parental occurrence of MI had an adverse cardiovascular risk factor profile regarding systolic and diastolic blood pressure, total cholesterol, the ratio between HDL and total cholesterol, and smoking. Thus, these modifiable risk factors may be mediators of the familial predisposition to MI.
Hippe
M
M
Copenhagen Centre for Prospective Population Studies, Institute of Preventive Medicine, Copenhagen University Hospital, Denmark.
Vestbo
J
J
Bjerg
A M
AM
Borch-Johnsen
K
K
Appleyard
M
M
Hein
H O
HO
Andersen
P K
PK
Jensen
G
G
Sørensen
T I
TI
D000328:Adult; D000367:Age Factors; D000368:Aged; D001794:Blood Pressure; D015992:Body Mass Index; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D003718:Denmark; D015444:Exercise; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000235:genetics* / Q000503:physiopathology; D016017:Odds Ratio; D010290:Parents; D011446:Prospective Studies; D012307:Risk Factors; D012907:Smoking; D014280:Triglycerides / Q000032:analysis
D008076:Cholesterol, HDL; D014280:Triglycerides; D002784:Cholesterol