title: [Changes in F-response parameters in supraspinal lesions of the central nervous system].
abstract: Since the F response is the result of antidromic activation of limited number of alpha motor neurons, the motor neurons excitability level can be investigated and established by analyzing parameter values of F response. The excitability of alpha motor neurons is the result of balance between excitatory and inhibitory influences of mainly supraspinal origin. The aim of this study was to perform the analysis of basic parameters of the F response in the lesions of pyramidal, extrapyramidal and cerebellar system, and to determine the eventual predictive value of the F response in lesion outcome. The investigations were carried out in 65 patients and 30 neurologically healthy subjects in control group. The patient group consisted of 38 patients with pyramidal lesions due to ischemic stroke, 15 patients with Parkinson's disease and 12 patients with vascular cerebellar lesions. The F response investigations were repeated monthly during 12 months in 12 patients with ischemic stroke. The results showed significant increase in F amplitude and frequency. These changes were in positive correlation with the increase of spastic muscular tone. In patients with cerebellar lesions decreased amplitude and frequency of F response were in positive correlation with the reduction of muscle tone. It was concluded that the measurement of the F response parameters might be reliable marker of the alpha motor neurons excitability and might have predictive value in the early phase of ischemic stroke.
authors.affiliation: Vojnomedicinska akademija, Klinika za neurologiju, Beograd.
authors.forename: A
authors.initials: A
authors.lastname: Jovicić
authors.forename: D
authors.initials: D
authors.lastname: Dordević
authors.forename: M
authors.initials: M
authors.lastname: Jovanović
authors.forename: S
authors.initials: S
authors.lastname: Petković
mesh_terms: D000328:Adult; D000368:Aged; D001927:Brain Diseases / Q000503:physiopathology*; D002545:Brain Ischemia / Q000503:physiopathology; D004576:Electromyography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009046:Motor Neurons / Q000502:physiology*; D010300:Parkinson Disease / Q000503:physiopathology