title: Propofol anaesthesia and vomiting after myringoplasty in children.
abstract: To determine whether propofol anaesthesia reduces the incidence of nausea and vomiting after ear surgery, 40 children aged 4-16 years were randomly assigned to receive either propofol or inhalational anaesthesia. Children in the propofol group had anaesthesia induced with propofol and maintained with propofol-nitrous oxide and those in the inhalational group had anaesthesia induced with thiopentone and maintained with isoflurane-nitrous oxide. Nausea and vomiting were recorded for 24 h after surgery and metoclopramide was offered to children who vomited more than twice. We found that 11 children (55%) who had propofol and 14 children (70%) who had inhalational anaesthesia vomited one or more times after surgery (difference not significant). The incidence of vomiting was lower in the propofol group during the first 2 h after surgery (0% and 25% propofol and inhalational groups, respectively) (p < 0.05) but was similar at all other time intervals. Rescue anti-emetic was given to two (10%) and eight (40%) children in the propofol and inhalational groups, respectively (p < 0.05). We conclude that propofol anaesthesia alone is not an effective means of preventing vomiting after middle ear surgery in children.
authors.affiliation: Department of Anaesthesia, Princess Margaret Hospital for Children, Perth, WA, Australia.
authors.forename: W
authors.initials: W
authors.lastname: Habre
authors.forename: C
authors.initials: C
authors.lastname: Sims
mesh_terms: D000293:Adolescent; D000769:Anesthesia, Inhalation; D000771:Anesthesia, Intravenous; D018686:Anesthetics, Intravenous; D002648:Child; D002675:Child, Preschool; D006801:Humans; D009225:Myringoplasty / Q000009:adverse effects*; D011183:Postoperative Complications / Q000517:prevention & control; D011184:Postoperative Period; D015742:Propofol; D013874:Thiopental; D014839:Vomiting / Q000209:etiology* / Q000517:prevention & control
chemical_list: D018686:Anesthetics, Intravenous; D013874:Thiopental; D015742:Propofol