Evaluation of commercially available assays of neopterin and beta 2-microglobulin for the assessment of disease progression in FIV-infected cats.
Serum or plasma samples from cats at different stages of feline immunodeficiency (FIV) infection and from uninfected cats were tested using immunoassays designed to detect human neopterin and beta 2-microglobulin (beta 2M). The results obtained from the anti-human neopterin assay did not correlate with infection status, time post-infection, fCD4 count or clinical picture. Feline samples gave negative results in the anti-human beta 2M assay. The assay kits used in this study are not suitable for the determination of the effect of FIV infection on immune activation markers in the cat.
Beatty
J A
JA
Department of Veterinary Pathology, University of Glasgow, UK.
Willett
B
B
Dalgleish
A
A
Jarrett
O
O
D000818:Animals; D001708:Biopterins / Q000031:analogs & derivatives* / Q000032:analysis / Q000276:immunology; D002371:Cat Diseases / Q000175:diagnosis* / Q000276:immunology; D002415:Cats; D018450:Disease Progression; D004797:Enzyme-Linked Immunosorbent Assay / Q000662:veterinary; D016181:Feline Acquired Immunodeficiency Syndrome / Q000175:diagnosis* / Q000276:immunology; D006801:Humans; D016089:Immunodeficiency Virus, Feline / Q000276:immunology*; D019798:Neopterin; D011933:Reagent Kits, Diagnostic / Q000662:veterinary*; D001613:beta 2-Microglobulin / Q000032:analysis* / Q000276:immunology
D011933:Reagent Kits, Diagnostic; D001613:beta 2-Microglobulin; D001708:Biopterins; D019798:Neopterin