A case-control study of self-reported exposures to pesticides and pancreas cancer in southeastern Michigan.
A case-control study of pancreas cancer in residents, aged 30-79 years, of 18 counties in southeastern Michigan was conducted to investigate the risks of exposure to DDT and related materials in the general population. Sixty-six people with cytologically diagnosed pancreas cancer were identified using 7 participating hospitals in metropolitan Detroit and Ann Arbor. One hundred and thirty-one controls were frequency-matched to the cases on age, sex, ethicity and county of residence by random-digit dialing. All study participants were administered a questionnaire to assess life-time exposure to pesticides from both environmental and occupational sources, family history of cancer, past medical history, smoking history and demographic information. A statistically significant increased risk was found for self-reported exposure to ethylan (1,1-dichloro-2,2-bis(4-methoxyphenyl) ethane). Increased odds ratios were observed for self-reported exposures to chloropropylate and DDT, as well as for the summary group of organochlorine pesticides which included all of these materials, though these associations were not significant.
Fryzek
J P
JP
Department of Preventive and Societal Medicine, University of Nebraska Medical Center, Omaha 68198-4350, USA. jfryzek@mail.unmc.edu
Garabrant
D H
DH
Harlow
S D
SD
Severson
R K
RK
Gillespie
B W
BW
Schenk
M
M
Schottenfeld
D
D
D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D003634:DDT / Q000009:adverse effects; D004781:Environmental Exposure; D005260:Female; D006801:Humans; D007306:Insecticides / Q000009:adverse effects*; D008297:Male; D008824:Michigan / Q000453:epidemiology; D008875:Middle Aged; D016273:Occupational Exposure; D016017:Odds Ratio; D010190:Pancreatic Neoplasms / Q000139:chemically induced / Q000453:epidemiology*; D010575:Pesticides / Q000009:adverse effects*; D012306:Risk; D012907:Smoking; D011795:Surveys and Questionnaires
D007306:Insecticides; D010575:Pesticides; D003634:DDT