title: Effects of LDL-apheresis on serum lipoprotein (a), C4b binding protein, protein C, protein S, and complement components.
abstract: The short-term effects of low-density lipoprotein (LDL) apheresis using a dextran sulfate-cellulose (DSC) column equipped with a plasma separator using a polysulfone (PS) membrane filter on the serum total cholesterol, lipoprotein(a) (Lp(a)), C4b binding protein (C4bp), protein C and protein S and complement components levels were examined in a patient with familial hypercholesterolemia (heterozygote, type IIa). PS/DSC-LDL apheresis markedly lowered the total cholesterol by 69.9 +/- 2.9%, serum Lp(a) level by 80.2 +/- 3.4%, and C4bp by 81.1 +/- 2.5% after 8 apheresis sessions. All the above parameters gradually returned to the baseline levels within 10 days. The free protein S level was not significantly changed, while the C4bp/protein S complex level was markedly decreased relative to the decrease in C4bp. The protein C level was moderately reduced by 29%. Almost all serum complements and complement co-factors as well as C4bp were moderately to markedly decreased after LDL apheresis, but returned to the initial levels within a few days. PS/DSC-LDL apheresis effectively eliminated both serum LDL and Lp(a), and did not have an adverse effect on fibrinolysis or complement cascade in the blood.
authors.affiliation: Third Department of Internal Medicine, Kagoshima University School of Medicine, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Yoshidome
authors.forename: M
authors.initials: M
authors.lastname: Kuriyama
authors.forename: K
authors.initials: K
authors.lastname: Shinmyozu
authors.forename: M
authors.initials: M
authors.lastname: Osame
mesh_terms: D000328:Adult; D001781:Blood Component Removal; D001798:Blood Proteins / Q000378:metabolism*; D002784:Cholesterol / Q000097:blood; D015935:Complement C4b; D003169:Complement Inactivator Proteins; D003165:Complement System Proteins / Q000378:metabolism; D005260:Female; D006023:Glycoproteins; D006579:Heterozygote; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000097:blood / Q000235:genetics / Q000628:therapy*; D017270:Lipoprotein(a) / Q000097:blood*; D008077:Lipoproteins, LDL / Q000097:blood*; D011486:Protein C / Q000378:metabolism; D017293:Protein S / Q000378:metabolism; D011951:Receptors, Complement / Q000097:blood*
chemical_list: D001798:Blood Proteins; D003169:Complement Inactivator Proteins; D006023:Glycoproteins; D017270:Lipoprotein(a); D008077:Lipoproteins, LDL; D011486:Protein C; D017293:Protein S; D011951:Receptors, Complement; D015935:Complement C4b; D003165:Complement System Proteins; D002784:Cholesterol