Marked effect of DNA on collagen fibrillogenesis in vitro.
Growth of collagen fibrils in the presence of DNA was more rapid than that in the absence of DNA. Some of collagen fibrils formed in the presence of DNA were significantly wider than those in the absence of DNA. Moreover, the cross-bandings were also very distinct in spite of using pepsin-digested collagen. These results suggest that DNA not only adsorbs to collagen but induces the extraordinary fibrillogenesis of collagen.
Kitamura
H
H
Division of Bioscience, Graduate School of Environmental Earth Science, Hokkaido University, Sapporo, Japan.
Iwamoto
C
C
Sakairi
N
N
Tokura
S
S
Nishi
N
N
D003094:Collagen / Q000737:chemistry* / Q000378:metabolism / Q000648:ultrastructure*; D004247:DNA / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D008854:Microscopy, Electron; D009391:Nephelometry and Turbidimetry; D010434:Pepsin A / Q000378:metabolism
D003094:Collagen; D004247:DNA; D010434:Pepsin A