Antihypertensive peptides derived from food proteins.
This paper reviews the angiotensin I converting enzyme inhibitory peptides originated from food materials and enzymatic hydrolysate of different kinds of proteins. Focus was put on the peptides derived from milk casein by the action of the proteolytic system of lactic acid bacteria. Some of the peptides exhibit significant antihypertensive effects in spontaneously hypertensive rats. Some new topics relating to these antihypertensive peptides are introduced. The possible significance of bioactive peptides derived from food in vivo is also discussed.
Yamamoto
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R&D Center, Calpis Food Industry Co., Ltd., Kanagawa, Japan.
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000737:chemistry* / Q000493:pharmacokinetics / Q000494:pharmacology; D000818:Animals; D000959:Antihypertensive Agents / Q000737:chemistry* / Q000493:pharmacokinetics / Q000494:pharmacology; D002364:Caseins / Q000737:chemistry; D004044:Dietary Proteins; D010450:Endopeptidases / Q000378:metabolism; D006801:Humans; D007408:Intestinal Absorption; D007778:Lactobacillus / Q000378:metabolism; D008894:Milk Proteins / Q000737:chemistry / Q000494:pharmacology; D010446:Peptide Fragments / Q000737:chemistry* / Q000493:pharmacokinetics / Q000494:pharmacology*; D007703:Peptidyl-Dipeptidase A / Q000378:metabolism
D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D002364:Caseins; D004044:Dietary Proteins; D008894:Milk Proteins; D010446:Peptide Fragments; D010450:Endopeptidases; D007703:Peptidyl-Dipeptidase A