title: Vaginal fistula following restorative proctocolectomy.
abstract: Vaginal fistula (VF) is a devastating complication following restorative proctocolectomy.
  
  
  OBJECTIVE
  This study was designed to examine the perioperative factors influencing the outcome and management of vaginal fistula.
  
  
  METHODS
  Between October 1983 and September 1994, 526 women underwent restorative proctocolectomy. Nineteen develop VF (3.6 percent), and six were referred from other institutions with this complication. These 25 women were followed for a minimum of nine months.
  
  
  RESULTS
  Preoperative diagnosis of ulcerative colitis was made in 23 of the patients with VF (92 percent), and indeterminate colitis and familial adenomatous polyposis was determined in the rest of the patients. Postoperatively, 12 of the 23 women (52 percent) with a preoperative diagnosis of ulcerative colitis had clinical/pathologic findings of Crohn's disease, and 1 woman was reclassified as having indeterminate colitis. Postoperative pelvic sepsis was significantly higher in women with VF than in those without VF (26.3 vs. 6.3 percent; P = 0.003). Median time until occurrence of VF following loop ileostomy closure was later for women with delayed findings of Crohn's disease at 16.5 (range, <1-72) months, compared with women without Crohn's disease at 0.5 (range, <1-67) months (P < 0.05). Of the 163 women with handsewn anastomosis performed at our institution, 12 developed VF (7.4 percent). In contrast, 7 of the 363 patients with stapled anastomosis had VF (1.9 percent; P = 0.003). Site of VF was found at the anastomosis in 12 patients, below in 12 patients, and above in 1 patient. Presence of Crohn's disease and anastomotic technique did not influence the site of VF. Initial management of VF consisted of transanal repair in 20 patients (advancement flap, 12; direct repair, 6; and neoileoanal anastomosis, 2), seton in 1 patient, transabdominal approach in 1 patient, transvaginal in 1 patient, observation in 1 patient, and pouch excision in 1 patient. Of the 13 women without Crohn's disease, 12 had transanal repair (10 healed, 1 had recurrence, and 1 had pouch excision), and 1 had successfully repair with transabdominal technique, for an overall success rate of 84.6 percent. Of the 12 women with VF and delayed findings of Crohn's disease, transanal repair was performed on 9, 1 had pouch excision without repair, 1 had seton placement and pouch excision, and 1 underwent observation. Transanal technique of repair in women with Crohn's disease successfully healed three women (33.3 percent). Overall, of the 12 women with delayed findings of Crohn's disease, 6 had pouch excision, 3 had recurrences, and 3 healed.
  
  
  CONCLUSIONS
  VF is an uncommon complication following restorative proctocolectomy and is associated with a high incidence of pelvic sepsis and handsewn anastomosis. Late presentation of VF is more common with Crohn's disease and is associated with a poor prognosis and pouch salvage rate. Transanal techniques are an effective means of VF repair.
authors.affiliation: Department of Colorectal Surgery, Cleveland Clinic Foundation, Ohio 44195, USA.
authors.forename: P Y
authors.initials: PY
authors.lastname: Lee
authors.forename: V W
authors.initials: VW
authors.lastname: Fazio
authors.forename: J M
authors.initials: JM
authors.lastname: Church
authors.forename: T L
authors.initials: TL
authors.lastname: Hull
authors.forename: K W
authors.initials: KW
authors.lastname: Eu
authors.forename: I C
authors.initials: IC
authors.lastname: Lavery
mesh_terms: D011125:Adenomatous Polyposis Coli / Q000150:complications / Q000601:surgery; D000293:Adolescent; D000328:Adult; D001003:Anal Canal / Q000601:surgery; D000714:Anastomosis, Surgical / Q000009:adverse effects / Q000379:methods; D003082:Colectomy; D003092:Colitis / Q000150:complications / Q000601:surgery; D003093:Colitis, Ulcerative / Q000150:complications / Q000601:surgery; D003424:Crohn Disease / Q000150:complications / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007081:Ileostomy / Q000009:adverse effects; D007082:Ileum / Q000601:surgery; D008875:Middle Aged; D016737:Proctocolectomy, Restorative / Q000009:adverse effects*; D011379:Prognosis; D012008:Recurrence; D012086:Reoperation; D018805:Sepsis / Q000209:etiology; D017792:Surgical Stapling / Q000009:adverse effects; D016896:Treatment Outcome; D014624:Vaginal Fistula / Q000209:etiology* / Q000601:surgery