title: Effects of cardiac autonomic imbalance on postnatal changes in the electrocardiographic Q-T interval in conscious swine.
abstract: The effects of partial autonomic denervation of the heart rate and Q--T interval were examined during maturation in swine. Four groups of newborns were prepared: right stellate ganglionectomy (RSG), left stellate ganglionectomy (LSG), right cardiac vagotomy (RCV) and sham-operated. Swine were studied postsurgically for eight weeks. Unexpected deaths of unknown cause occurred in five of the 20 denervated swine but in none of the 10 sham-operated controls. Prolongation of the Q--T interval was greatest in RSG animals and least in RCV as compared to controls. The results indicate that we have successfully developed an animal model of a long Q--T syndrome in swine.
authors.affiliation: Department of Physiology, SUNY Health Science Center at Brooklyn 11203, USA.
authors.forename: S
authors.initials: S
authors.lastname: Tong
authors.forename: S
authors.initials: S
authors.lastname: Ingenito
authors.forename: I D
authors.initials: ID
authors.lastname: Frasier
authors.forename: A L
authors.initials: AL
authors.lastname: Sica
authors.forename: N
authors.initials: N
authors.lastname: Gootman
authors.forename: P M
authors.initials: PM
authors.lastname: Gootman
mesh_terms: D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D001341:Autonomic Nervous System / Q000502:physiology*; D004562:Electrocardiography; D005260:Female; D015171:Ganglionectomy; D006329:Heart Conduction System / Q000502:physiology*; D006339:Heart Rate; D008297:Male; D013233:Stellate Ganglion / Q000502:physiology; D013552:Swine; D014628:Vagotomy; D014630:Vagus Nerve / Q000502:physiology