[Alcohol intake and risk of liver disease--significance of gender. A population study].
The association between self-reported alcohol intake and the risk of future liver disease was studied in a population-based prospective cohort of 13,285 men and women aged 30-79 years. Diagnoses indicating alcoholic liver disease (n = 261) or cirrhosis (n = 124) were obtained from the Danish National Health Registers. The cumulated observation time was 130,558 person-years. A dose-dependent increase in risk of developing liver disease was observed with increasing alcohol intake, with the steepest increase among women. At an alcohol intake of 7-13 beverages per week for women and 14-27 beverages per week for men the relative risk was significantly greater than 1. Women had a significantly higher relative risk of developing alcohol related liver disease than men for any given level of alcohol intake. In the general population, self-reported current alcohol intake is a good predictor of the future risk of alcoholic liver disease.
Becker
P U
PU
Kommunehospitalet, Center for Epidemiologisk Grundforskning, Kabenhavn.
Deis
A
A
Sørensen
T I
TI
Grønbaek
M N
MN
Borch-Johnsen
K
K
Müller
C F
CF
Schnohr
P
P
Jensen
G B
GB
D000328:Adult; D000368:Aged; D000428:Alcohol Drinking / Q000009:adverse effects*; D000437:Alcoholism / Q000150:complications / Q000453:epidemiology; D056486:Chemical and Drug Induced Liver Injury; D005260:Female; D006801:Humans; D008104:Liver Cirrhosis, Alcoholic / Q000453:epidemiology / Q000209:etiology; D008107:Liver Diseases / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D012649:Self Concept; D012737:Sex Factors