title: Continuous extradural infusion of ropivacaine 2 mg ml-1 for pain relief during labour.
abstract: We have assessed the dose-response relationship of a solution of ropivacaine 2 mg ml-1, given as a continuous extradural infusion to women in labour. A total of 133 parturients were allocated randomly to one of four groups to receive a fixed rate ropivacaine infusion of 4, 6, 8 or 10 ml h-1 with additional bolus doses as necessary. Contraction pain, quality of analgesia, sensory block, motor block and neonatal Apgar scores were assessed. There were no significant differences between groups in terms of analgesia or motor block, although significantly more bolus doses were required by the group receiving 4 ml h-1 (P < 0.05 compared with the other groups), and a significantly higher total dose of ropivacaine was administered to the 10-ml h-1 group compared with the 6-ml h-1 group (P = 0.044). There were no significant differences between groups in terms of obstetric or neonatal outcome. We conclude that ropivacaine 2 mg ml-1 was effective and well tolerated when given as a continuous extradural infusion at 6-8 ml h-1 and may be used as the sole analgesic during labour.
authors.affiliation: Hôpital Antoine-Béclère, Département Anesthésie, Clamart, France.
authors.forename: D
authors.initials: D
authors.lastname: Benhamou
authors.forename: J
authors.initials: J
authors.lastname: Hamza
authors.forename: J J
authors.initials: JJ
authors.lastname: Eledjam
authors.forename: P
authors.initials: P
authors.lastname: Dailland
authors.forename: M
authors.initials: M
authors.lastname: Palot
authors.forename: J
authors.initials: J
authors.lastname: Seebacher
authors.forename: D
authors.initials: D
authors.lastname: Milon
authors.forename: K
authors.initials: K
authors.lastname: Heeroma
mesh_terms: D000577:Amides / Q000008:administration & dosage*; D015360:Analgesia, Epidural / Q000379:methods*; D016362:Analgesia, Obstetrical / Q000379:methods*; D000779:Anesthetics, Local / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D011247:Pregnancy; D000077212:Ropivacaine
chemical_list: D000577:Amides; D000779:Anesthetics, Local; D000077212:Ropivacaine