title: Impact of local evidence-based clinical guidelines--a Danish intervention study.
abstract: OBJECTIVE
  We aimed to evaluate whether a cheap and less labour-intensive regional implementation strategy for guidelines was sufficient to change knowledge and behaviour among GPs. The model studied was the implementation of anticoagulant therapy to prevent stroke in atrial fibrillation.
  
  
  METHODS
  The intervention took place in the county of Viborg (149 GPs), Denmark, with the county of Ringkøbing (166 GPs) as control. A local interdisciplinary steering group modified national college-based guidelines, followed by a regional dissemination and implementation strategy. The effect of the intervention was evaluated during a follow-up period by a repeated questionnaire and by monitoring prescriptions for oral anticoagulants in 1993 and 1995 in the Danish National Health Service.
  
  
  RESULTS
  Adherence to the guidelines was higher after the intervention but, considering secular trends and baseline differences, the guidelines had no significant effect. The use of oral anticoagulants increased substantially in both counties during the 2-year follow-up period, but the difference in relative change between the counties was negligible. Adherence to the guidelines could not be predicted by any of the reported practice characteristics or attitudes to guidelines.
  
  
  CONCLUSIONS
  Despite solid scientific documentation and regional modification to establish ownership of nationally agreed guidelines, the impact of guidelines on GPs' knowledge and behaviour was disappointing.
authors.affiliation: Research Unit for General Practice, University of Aarhus, Denmark.
authors.forename: F H
authors.initials: FH
authors.lastname: Steffensen
authors.forename: H T
authors.initials: HT
authors.lastname: Sørensen
authors.forename: F
authors.initials: F
authors.lastname: Olesen
mesh_terms: D000925:Anticoagulants / Q000627:therapeutic use*; D001281:Atrial Fibrillation / Q000188:drug therapy*; D001291:Attitude of Health Personnel; D002561:Cerebrovascular Disorders / Q000517:prevention & control*; D002983:Clinical Competence; D016001:Confidence Intervals; D003718:Denmark; D004502:Education, Medical, Continuing / Q000191:economics / Q000379:methods / Q000592:standards*; D005194:Family Practice / Q000193:education* / Q000592:standards*; D019538:Health Care Surveys; D006801:Humans; D016015:Logistic Models; D008137:Longitudinal Studies; D016017:Odds Ratio; D015397:Program Evaluation; D011787:Quality of Health Care / Q000639:trends; D012042:Registries / Q000706:statistics & numerical data
chemical_list: D000925:Anticoagulants