Antidotal efficacy of quinuclidinium oximes against soman poisoning.
The efficiency of newly synthesized oxime derivatives of quinuclidinium were tested in vitro on soman inhibited acetylcholinesterase (AChE) of human erythrocytes and in vivo using soman poisoned mice. For this purpose, the inhibitory power of oximes (IC50), acute toxicity (LD50) as well as reactivating and protective capacities with respect to soman-inhibited AChE were determined for each of the oximes. All oximes tested were ineffective in vitro but protected mice very efficiently (BM-1 protects against 4LD50 of soman). The results indicate that the in vivo effectiveness of quinuclidinium oximes against soman poisoning may not be related to reactivation or protection of AChE but rather to some other mechanism of the cholinergic system.
Lucić
A
A
Laboratorij za toksikologiju, Institut za medicinska istrazivanja i medicinu rada, Zagreb, Hrvatska.
Radić
B
B
Peraica
M
M
Mesić
M
M
Primozic
I
I
Binenfeld
Z
Z
D000110:Acetylcholinesterase / Q000097:blood; D000818:Animals; D000931:Antidotes / Q000627:therapeutic use*; D002801:Cholinesterase Reactivators / Q000097:blood / Q000627:therapeutic use; D004912:Erythrocytes / Q000187:drug effects / Q000201:enzymology; D006801:Humans; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010091:Oximes / Q000627:therapeutic use*; D011812:Quinuclidines / Q000627:therapeutic use*; D012999:Soman / Q000037:antagonists & inhibitors* / Q000506:poisoning*
D000931:Antidotes; D002801:Cholinesterase Reactivators; D010091:Oximes; D011812:Quinuclidines; D012999:Soman; D000110:Acetylcholinesterase