title: Recent advances in the discovery and development of topoisomerase inhibitors as antitumor agents.
authors.affiliation: Natural Products Laboratory, School of Pharmacy, University of North Carolina, Chapel Hill 27599, USA.
authors.forename: H K
authors.initials: HK
authors.lastname: Wang
authors.forename: S L
authors.initials: SL
authors.lastname: Morris-Natschke
authors.forename: K H
authors.initials: KH
authors.lastname: Lee
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D002166:Camptothecin / Q000737:chemistry / Q000494:pharmacology; D002626:Chemistry, Pharmaceutical; D017076:Computer-Aided Design; D015195:Drug Design; D006801:Humans; D007928:Lethal Dose 50; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy*; D013329:Structure-Activity Relationship; D059004:Topoisomerase I Inhibitors; D059005:Topoisomerase II Inhibitors; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D000970:Antineoplastic Agents; D059004:Topoisomerase I Inhibitors; D059005:Topoisomerase II Inhibitors; D002166:Camptothecin