title: [Knudson's "two-hit" hypothesis in familial cancer syndromes].
abstract: Cancer is a heritable disorder of somatic cells. Environment and hereditary both operate in the origin of human cancer. Hereditary cancer is rare, but it has served as a useful model in the understanding of carcinogenesis. A number of cancer genes have been identified by the study of hereditary cancers and implicated in sporadic forms of the same tumors. In this article, I reviewed Knudson's famous "two-hit" hypothesis of tumor suppression.
authors.affiliation: Dept. of Experimental Pathology, Cancer Institute.
authors.forename: O
authors.initials: O
authors.lastname: Hino
mesh_terms: D016147:Genes, Tumor Suppressor; D006801:Humans; D008962:Models, Theoretical; D009386:Neoplastic Syndromes, Hereditary / Q000235:genetics*