title: FDG hypermetabolism associated with inflammatory necrotic changes following radiation of meningioma.
abstract: PET with 18F-fluoro-2-deoxy-D-glucose (FDG) is currently the noninvasive gold standard for distinguishing brain tumor recurrence from radiation necrosis. We present a case report that appears to contradict this doctrine. The patient had a history of atypical meningioma and was treated with surgical resection and postoperative proton-beam radiation therapy. Approximately 16 mo after completion of therapy, MRI demonstrated two new regions of enhancement, and an FDG-PET study was performed to further characterize these lesions. FDG-PET demonstrated an area of intense hypermetabolism, and wide surgical resection was performed. Histological examination of the surgical specimen revealed reactive changes and areas of necrosis. There was no evidence of either recurrent or radiation-induced tumor.
authors.affiliation: Department of Radiology, Massachusetts General Hospital, Boston 02114, USA.
authors.forename: A J
authors.initials: AJ
authors.lastname: Fischman
authors.forename: A F
authors.initials: AF
authors.lastname: Thornton
authors.forename: M P
authors.initials: MP
authors.lastname: Frosch
authors.forename: B
authors.initials: B
authors.lastname: Swearinger
authors.forename: R G
authors.initials: RG
authors.lastname: Gonzalez
authors.forename: N M
authors.initials: NM
authors.lastname: Alpert
mesh_terms: D000368:Aged; D001921:Brain / Q000000981:diagnostic imaging* / Q000473:pathology / Q000528:radiation effects; D001932:Brain Neoplasms / Q000000981:diagnostic imaging* / Q000532:radiotherapy / Q000601:surgery; D003131:Combined Modality Therapy; D003847:Deoxyglucose / Q000031:analogs & derivatives*; D003937:Diagnosis, Differential; D003951:Diagnostic Errors; D005260:Female; D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008579:Meningioma / Q000000981:diagnostic imaging* / Q000532:radiotherapy / Q000601:surgery; D009336:Necrosis; D009364:Neoplasm Recurrence, Local; D011832:Radiation Injuries / Q000000981:diagnostic imaging*; D014055:Tomography, Emission-Computed
chemical_list: D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D003847:Deoxyglucose