Effect of endothelin-1 on some hemostatic parameters in normotensive rats.
Some parameters of hemostasis and fibrinolysis were investigated in rats administered with endothelin-1 (ET-1). ET-1 (0.5, 1.0, 5.0 nmol/kg) dose-dependently shortened the bleeding time (BT). Concomitantly significant shortening of the clotting time (CT) was observed. ET-1 produced prolongation of the activated partial thromboplastin time (APTT), whereas prothrombin time (PT) remained unchanged. ET-1 did not influence in vitro platelet aggregation induced by ADP and collagen. The euglobulin clot lysis time (ECLT) was significantly shortened after ET-1 administration. Our results suggest that ET-1 modulates the process of hemostasis and fibrinolysis in the rat.
Pietraszek
M
M
Department of Pharmacodynamics, Medical School, Białystok, Poland.
Chabielska
E
E
Azzadin
A
A
Pawlak
R
R
Buczko
W
W
D000818:Animals; D001760:Bleeding Time; D001777:Blood Coagulation / Q000187:drug effects; D001794:Blood Pressure; D004305:Dose-Response Relationship, Drug; D019332:Endothelin-1 / Q000494:pharmacology*; D005342:Fibrinolysis / Q000187:drug effects; D006487:Hemostasis / Q000187:drug effects*; D008297:Male; D010314:Partial Thromboplastin Time; D051381:Rats; D017208:Rats, Wistar; D012016:Reference Values; D013997:Time Factors
D019332:Endothelin-1