Stobadine pretreatment enhances glutathione peroxidase activity in the heart of irradiated mice.
The effect of pretreatment with stobadine (a novel drug with cardioprotective properties) on the activity of glutathione peroxidase was studied in the heart of mice after Co60 irradiation. Exposure to 6.5 Gy caused significant decrease in the activity of the enzyme (p < 0.01). Treatment with stobadine (70.07 mg/kg) 1 or 2 h before irradiation resulted in activity enhancement in comparison with the nonpretreated irradiated group (p < 0.01). We conclude that the radical scavenging mechanism may be involved in the protection exerted by stobadine. The results are in agreement with those obtained by the micronucleus test.
Kováciková
Z
Z
Institute of Preventive and Clinical Medicine, Bratislava, Slovak Republic.
Chorvatovicová
D
D
Ginter
E
E
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology*; D002243:Carbolines / Q000494:pharmacology*; D003037:Cobalt Radioisotopes / Q000009:adverse effects; D005979:Glutathione Peroxidase / Q000187:drug effects*; D006321:Heart / Q000187:drug effects* / Q000528:radiation effects; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009206:Myocardium / Q000201:enzymology*; D011837:Radiation-Protective Agents / Q000494:pharmacology*
D000889:Anti-Arrhythmia Agents; D002243:Carbolines; D003037:Cobalt Radioisotopes; D011837:Radiation-Protective Agents; D005979:Glutathione Peroxidase; C100106:dicarbine