title: A comparative study of high-fat diet containing fish oil or lard on blood glucose in genetically diabetic (db/db) mice.
abstract: The effects of high-fat diets containing fish oil or lard on blood glucose and plasma insulin after oral glucose loading were compared in genetically diabetic (db/db) mice, one of the animal models of non-insulin-dependent diabetes mellitus (NIDDM) with hyperinsulinemia. The blood glucose levels were significantly decreased in 27% of the mice fed high-fat diets containing 20% fish oil 30 and 60 min after the oral administration of glucose (both; p < 0.05). Conversely, the plasma insulin levels were significantly increased 30 min after the glucose loading as compared to 27% of the mice fed high-fat diets containing 20% lard (p < 0.01). In addition, a significant hypoglycemic effect was observed 60 min after the subcutaneous administration of insulin to mice on the fish oil diet (p < 0.05), whereas no effect was demonstrated in the case of those on the lard diet. The average body weight of the fish oil-treated mice was not significantly different from that of the lard-treated mice. The fish oil diet has a beneficial effect on glucose tolerance by increasing the insulin secretory capacity from pancreatic beta cells and also ameliorating insulin resistance.
authors.affiliation: Suzuka University of Medical Science and Technology, Mie, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Miura
authors.forename: Y
authors.initials: Y
authors.lastname: Ohnishi
authors.forename: S
authors.initials: S
authors.lastname: Takagi
authors.forename: M
authors.initials: M
authors.lastname: Sawamura
authors.forename: N
authors.initials: N
authors.lastname: Yasuda
authors.forename: H
authors.initials: H
authors.lastname: Ishida
authors.forename: K
authors.initials: K
authors.lastname: Tanigawa
authors.forename: Y
authors.initials: Y
authors.lastname: Yamori
authors.forename: Y
authors.initials: Y
authors.lastname: Seino
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000032:analysis*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000235:genetics; D004041:Dietary Fats / Q000008:administration & dosage*; D004195:Disease Models, Animal; D005395:Fish Oils / Q000008:administration & dosage*; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D051379:Mice
chemical_list: D001786:Blood Glucose; D004041:Dietary Fats; D005395:Fish Oils; D007328:Insulin; C029310:lard