Genetic determinants of high density lipoprotein levels.
Low serum concentrations of HDL-cholesterol are well established markers for a high risk to develop coronary artery disease. The absence of coronary artery disease symptoms from some individuals with familial HDL deficiency demonstrates the presence of heterogeneity in this relation and points to an important role of etiologic and modifying factors.
Funke
H
H
Institute of Clinical Chemistry, University of Münster, Germany.
D000818:Animals; D008076:Cholesterol, HDL / Q000097:blood; D003327:Coronary Disease / Q000097:blood / Q000453:epidemiology / Q000235:genetics*; D004195:Disease Models, Animal; D030342:Genetic Diseases, Inborn / Q000201:enzymology / Q000235:genetics; D008040:Genetic Linkage; D006801:Humans; D007863:Lecithin Cholesterol Acyltransferase Deficiency / Q000235:genetics; D008075:Lipoproteins, HDL / Q000096:biosynthesis / Q000172:deficiency* / Q000235:genetics*; D007862:Phosphatidylcholine-Sterol O-Acyltransferase / Q000235:genetics; D012307:Risk Factors
D008076:Cholesterol, HDL; D008075:Lipoproteins, HDL; D007862:Phosphatidylcholine-Sterol O-Acyltransferase