Effects of antioxidants on ischemic retinal dysfunction.
Transient occlusion of both common carotid arteries in normotensive rats leads to a reduction in the amplitude of the b-wave of the electroretinogram (ERG). The present study investigated whether the antioxidants vitamin E and lipoate attenuate the depression and enhance the recovery of the b-wave of the ERG in response to retinal ischemia. The ERG was recorded from halothane-anesthetized rats before. during and after transient (24 min) occlusion of both common carotid arteries. The substances were administered 20 minutes before or at the onset of ischemia. Both vitamin E (100 mg kg-1) and lipoate (100 mg kg-1) significantly reduced the depression of the b-wave during occlusion and accelerated recovery during reperfusion at either time point of application. The present results suggest that antioxidants provide protection against ischemic retinal dysfunction.
Block
F
F
Department of Neurology, University of Essen, Germany.
Schwarz
M
M
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D004596:Electroretinography / Q000187:drug effects; D007511:Ischemia; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012171:Retinal Vessels / Q000187:drug effects / Q000378:metabolism; D008063:Thioctic Acid / Q000031:analogs & derivatives / Q000494:pharmacology; D014810:Vitamin E / Q000494:pharmacology
D000975:Antioxidants; D014810:Vitamin E; D008063:Thioctic Acid