Enhancing adenosine A1 receptor binding reduces hypoxic-ischemic brain injury in newborn rats.
Hypoxia increases brain adenosine concentrations, which provides neuroprotection through activation of central adenosine A1 receptors. This study was carried out to determine whether PD 81,273, which increases adenosine's binding to A1 receptors, would reduce hypoxia-induced brain injury. PD 81,273 (3 mg/kg, i.p.) decreased by about 50% the weight loss of the left cerebral hemisphere caused by hypoxia-ischemia in neonatal rats. Thus, enhancing adenosine's binding to the A1 receptor decreases hypoxic brain damage.
Halle
J N
JN
Department of Obstetrics and Gynecology and The Brain Research Institute, School of Medicine, University of California, Los Angeles 90095-1740, USA. jhalle@ucla.edu
Kasper
C E
CE
Gidday
J M
JM
Koos
B J
BJ
D000818:Animals; D000831:Animals, Newborn / Q000502:physiology; D001930:Brain Injuries / Q000378:metabolism*; D002545:Brain Ischemia / Q000378:metabolism*; D000860:Hypoxia / Q000378:metabolism*; D058906:Purinergic P1 Receptor Agonists; D051381:Rats; D017207:Rats, Sprague-Dawley; D013876:Thiophenes / Q000494:pharmacology*
D058906:Purinergic P1 Receptor Agonists; D013876:Thiophenes