title: Aztreonam/clavulanic acid in the treatment of serious infections caused by Stenotrophomonas maltophilia in neutropenic patients: case reports.
abstract: Two seriously neutropenic patients (a 23-year-old man with a promyelocytic acute myeloid leukemia [AML-M3] and a 77-year old male with an immature acute myeloid leukemia [AML-M1] diagnosis) with severe infections caused by Stenotrophomonas maltophilia were treated with aztreonam/clavulanic acid (2:1) combination. In the first patient the infection was caused by a multiresistant strain and in the second, by a strain with poor response to trimethoprim-sulfamethoxazole and other antimicrobial agents. After treatment with aztreonam/clavulanic acid both patients evolved favorably.
authors.affiliation: Departmento de Microbiologìa y Parasitologìa, Hospital Universitario, Salamanca, Spain.
authors.forename: J E
authors.initials: JE
authors.lastname: García Sánchez
authors.forename: M L
authors.initials: ML
authors.lastname: Vazquez López
authors.forename: A M
authors.initials: AM
authors.lastname: Blazquez de Castro
authors.forename: J A
authors.initials: JA
authors.lastname: Perez Simon
authors.forename: N G
authors.initials: NG
authors.lastname: Gutierrez
authors.forename: I T
authors.initials: IT
authors.lastname: Martin
authors.forename: J A
authors.initials: JA
authors.lastname: García-Rodríguez
mesh_terms: D000328:Adult; D000368:Aged; D001398:Aztreonam / Q000627:therapeutic use*; D019818:Clavulanic Acid; D002969:Clavulanic Acids / Q000627:therapeutic use*; D018432:Drug Resistance, Multiple; D004359:Drug Therapy, Combination / Q000627:therapeutic use*; D016905:Gram-Negative Bacterial Infections / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D007951:Leukemia, Myeloid / Q000150:complications; D008297:Male; D009503:Neutropenia / Q000209:etiology*; D014974:Xanthomonas / Q000187:drug effects*
chemical_list: D002969:Clavulanic Acids; D019818:Clavulanic Acid; D001398:Aztreonam