title: A randomized, double-blind trial of parenteral low dose versus high dose interferon-beta in combination with cryotherapy for treatment of condyloma acuminatum.
abstract: Forty-nine subjects were enrolled in a study comparing two dosages of parenterally administered interferon (IFN)-beta in combination with cryotherapy for the treatment of anogenital warts. Subjects were randomized to receive subcutaneous injections of either 2 x 10(6) or 4 x 10(6) IU/m2 of IFN-beta (Biogen) three times a week for a total of 6 weeks. Cryotherapy was administered concomitantly by aerosolization of liquid nitrogen at 10-day intervals. Systemic side- effects were modest in intensity and included fever, chills, myalgia, and headaches (flu-like symptoms). During the first 2 weeks of therapy, they were more common in the high dose group than in the low dose group (P = 0.02). Using survival analysis, there was no significant difference between the two groups in rates of resolution of warts present at baseline (P = 0.62). However, the rate of new lesion formation during the study was significantly lower in the high dose group (P = 0.04).
authors.affiliation: Department of Medicine, University of Rochester, New York 14642, USA.
authors.forename: W
authors.initials: W
authors.lastname: Bonnez
authors.forename: D
authors.initials: D
authors.lastname: Oakes
authors.forename: A
authors.initials: A
authors.lastname: Bailey-Farchione
authors.forename: A
authors.initials: A
authors.lastname: Choi
authors.forename: D
authors.initials: D
authors.lastname: Hallahan
authors.forename: L
authors.initials: L
authors.lastname: Corey
authors.forename: G
authors.initials: G
authors.lastname: Barnum
authors.forename: P G
authors.initials: PG
authors.lastname: Pappas
authors.forename: M
authors.initials: M
authors.lastname: Halloway
authors.forename: M H
authors.initials: MH
authors.lastname: Stoler
authors.forename: R C
authors.initials: RC
authors.lastname: Reichman
mesh_terms: D000328:Adult; D003131:Combined Modality Therapy; D003218:Condylomata Acuminata / Q000628:therapy*; D017679:Cryotherapy; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007279:Injections, Subcutaneous; D016899:Interferon-beta / Q000008:administration & dosage* / Q000009:adverse effects; D008297:Male; D012008:Recurrence
chemical_list: D016899:Interferon-beta