Mouse lung immune response after acute exposure to flour dust.
To approach the physiopathology of the mucosal immune response in flour-mill and bakery workers, the authors developed a mouse model, which allowed them to study immune responses induced in the deep lung by acute inhalation of flour dust. In situ quantification of T lymphocytes (Thy1-2) and T-cell subsets (CD4 and CD8), macrophages, B lymphocytes, and immunoglobulin A plasma cells in the lungs of all animals revealed significant modifications of these cell compartments as early as 3 d after exposure; within 10 d of exposure, levels returned to baseline. The data suggest that the lung could be a sensitive target for inhaled xenobiotics, which might generate rapid immune local modifications that result in the maintenance of homeostasis.
Kolopp-Sarda
M N
MN
Laboratoire d'Immunologie, Faculté de Médecine de Nancy, Vandoeuvre-lès-Nancy, France.
Béné
M C
MC
Martin
P
P
Faure
G C
GC
D000280:Administration, Inhalation; D000818:Animals; D004391:Dust / Q000009:adverse effects*; D005433:Flour / Q000009:adverse effects*; D005455:Fluorescent Antibody Technique / Q000706:statistics & numerical data; D007111:Immunity, Cellular / Q000187:drug effects; D008168:Lung / Q000187:drug effects / Q000276:immunology*; D016676:Macrophages, Alveolar / Q000187:drug effects / Q000201:enzymology; D008297:Male; D051379:Mice; D013997:Time Factors
D004391:Dust