Chemical composition and antimicrobial activity of Croton urucurana Baillon (Euphorbiaceae).
In the methanolic extract of Croton urucurana Baillon (Euphorbiaceae) a number of known compounds, such as acetyl aleuritolic acid, stigmasterol, beta-sitosterol, campesterol, beta-sitosterol-O-glucoside, sonderianin, catechin and gallocatechin were isolated and identified by MS and NMR spectroscopy, HRGC and data from literature. The antibacterial activity of the aqueous-EtOH extract, some fractions of the methanolic extract and some of the isolated compounds, were tested against Staphylococcus aureus and Salmonella typhimurium. Acetyl aleuritolic acid exhibits the best minimum inhibitory concentration (MIC) against both Staphylococcus aureus and Salmonella typhimurium.
Peres
M T
MT
Departamento de Ciencias Biológicas, Universidade Federal de Mato Grosso do Sul, Centro Universitário, Dourados, MS, Brazil.
Delle Monache
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F
Cruz
A B
AB
Pizzolatti
M G
MG
Yunes
R A
RA
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001938:Brazil; D008519:Medicine, Traditional; D008826:Microbial Sensitivity Tests; D010936:Plant Extracts / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D012486:Salmonella typhimurium / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects; D014197:Trees / Q000737:chemistry; D014315:Triterpenes / Q000302:isolation & purification / Q000494:pharmacology; D014946:Wound Infection / Q000188:drug therapy
D000900:Anti-Bacterial Agents; D010936:Plant Extracts; D014315:Triterpenes; C014947:acetylaleuritolic acid