title: [New strategies for the etiologic study of interstitial pneumonia: familial registration and sib-pair analysis].
abstract: Etiology of idiopathic interstitial pneumonia (IIP) remains unknown. While many studies focused on the analysis of individual patients, available information is limited for the further study. Having experienced a case, 3 of 5 brothers suffered from IIP and 2 of them complicated with lung cancer, intensive familial history taking with chest photos and functional information for fibrotic lung was performed. Among 37 families in which at least 2 members were examined, 14 families (37.8%) had minimum 2 members with fibrotic lungs. Unexpectedly high familial accumulation of fibrotic lung indicates the possibility of multi-gene involvement for the pathogenesis. We need to start group studies to register sib-pairs with fibrotic lungs and systematize the automated genetic analysis for the responsible genes.
authors.affiliation: Institute of Development, Aging and Cancer, Tohoku University.
authors.forename: T
authors.initials: T
authors.lastname: Nukiwa
authors.forename: B
authors.initials: B
authors.lastname: Uchiyama
mesh_terms: D017668:Age of Onset; D005819:Genetic Markers; D006801:Humans; D007564:Japan; D017563:Lung Diseases, Interstitial / Q000235:genetics*; D008297:Male; D018895:Microsatellite Repeats; D005810:Multigene Family; D009679:Nuclear Family; D012042:Registries
chemical_list: D005819:Genetic Markers