[Changes of circulating Lps and cytokines in burned patients after anti-endotoxin therapy].
OBJECTIVE
Endotoxin as the inciting agent of cytokines and other mediators, whose high level expression correlates with the septic shock and MOF, has been the one of leading causes of death in ICU.


METHODS
For treating sepsis and MOF caused by endotoxin, the anti-lipid A of LPS antibody was used, 19 burned patients whose TBSA varied from 50% to 100% were divided into anti-LPS treatment group and nontreated group.


RESULTS
The levels of serum endotoxin, IL-6, IL-8, TNF and soluble IL-2R were lower obviously in patients of anti-LPS group than those of nontreated group (P < 0.05).


CONCLUSIONS
Clinical study surggests that anti-lipid A of LPS antibody can act as an therapeutic agent against gram-negative bacterin infection in burned patients.
Fu
W
W
Institute of Burns Research, South-West Hospital, Third Military Medical University, Chongqing.
Xiao
G
G
Yu
P
P
D000328:Adult; D000906:Antibodies / Q000627:therapeutic use; D000992:Antitoxins / Q000627:therapeutic use*; D002056:Burns / Q000150:complications / Q000628:therapy*; D016207:Cytokines / Q000378:metabolism*; D019446:Endotoxemia / Q000209:etiology / Q000517:prevention & control*; D004731:Endotoxins / Q000276:immunology*; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D016209:Interleukin-8 / Q000097:blood; D008050:Lipid A / Q000276:immunology*; D008297:Male; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D000906:Antibodies; D000992:Antitoxins; D016207:Cytokines; D004731:Endotoxins; D015850:Interleukin-6; D016209:Interleukin-8; D008050:Lipid A; D014409:Tumor Necrosis Factor-alpha