title: The individual and combined effects of the Fusarium mycotoxins moniliformin and fumonisin B1 in turkeys.
abstract: Fumonisin B1 (FB1) and moniliformin (M) were supplied by Fusarium moniliforme M-1325 and Fusarium fujikuroi M-1214 culture material, respectively. Turkeys were fed a control ration, or rations containing 200 mg FB1/kg, 100 mg M/kg, or a combination of both 200 mg FB1/kg and 100 mg M/kg feed from 1 to 21 days of age. These rations contained 0, 3.8, 1.0, and 4.8% culture material, respectively. In comparison to controls, turkeys fed FB1 had increased relative liver weights. Both aspartate aminotransferase and lactate dehydrogenase were increased in poults fed FB1. Turkeys fed M had decreased feed intake and body weight gains and increased relative heart weights in comparison to controls. Poults fed FB1 had moderate diffuse hepatocellular hyperplasia and poults fed moniliformin had a loss of cardiomyocyte cross striations. Turkeys fed the ration containing both M and FB1 had all the above changes; however, no additive or synergistic effects were evident for any single parameter measured. No treatment-related morbidity or mortality was observed in the study.
authors.affiliation: Fusarium/Poultry Research Laboratory, University of Missouri, Columbia 65211, USA.
authors.forename: A J
authors.initials: AJ
authors.lastname: Bermudez
authors.forename: D R
authors.initials: DR
authors.lastname: Ledoux
authors.forename: G E
authors.initials: GE
authors.lastname: Rottinghaus
authors.forename: G A
authors.initials: GA
authors.lastname: Bennett
mesh_terms: D000821:Animal Feed; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001835:Body Weight / Q000187:drug effects*; D002264:Carboxylic Acids / Q000008:administration & dosage / Q000633:toxicity*; D003503:Cyclobutanes / Q000008:administration & dosage / Q000633:toxicity*; D004347:Drug Interactions; D037341:Fumonisins; D005670:Fusarium / Q000254:growth & development; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D009183:Mycotoxins / Q000008:administration & dosage / Q000633:toxicity*; D009929:Organ Size / Q000187:drug effects; D012016:Reference Values; D014422:Turkeys; D015430:Weight Gain / Q000187:drug effects
chemical_list: D002264:Carboxylic Acids; D003503:Cyclobutanes; D037341:Fumonisins; D009183:Mycotoxins; C008539:moniliformin; C056933:fumonisin B1; D007770:L-Lactate Dehydrogenase; D001219:Aspartate Aminotransferases