title: The renewal of the epidermis: a topological mechanism.
abstract: Using a topological approach, we study the dynamics of the basement membrane of the mammalian epidermis when basal cells detach or divide. A theoretical characterization of the steady state of the tissue, in very good agreement with experimental data, includes for the first time the division and the disappearance of cells in a two-dimensional random cellular structure. We predict a strong correlation between the size of the attachment of basal cells to the basement membrane and their biological behavior (division or detachment). This suggests that the main factor determining the fate of basal cells, and thus controlling the renewal of the epidermis, is the cells' surface tension and adhesion.
authors.affiliation: Laboratoire de Dynamique des Fluides Complexes, Université Louis Pasteur, Strasbourg, France. dubertret@fresnel.u.strasbg.fr
authors.forename: B
authors.initials: B
authors.lastname: Dubertret
authors.forename: N
authors.initials: N
authors.lastname: Rivier
mesh_terms: D000818:Animals; D001485:Basement Membrane / Q000166:cytology / Q000502:physiology*; D002455:Cell Division; D003198:Computer Simulation; D000078404:Epidermal Cells; D004817:Epidermis / Q000502:physiology*; D008322:Mammals; D008433:Mathematics; D008954:Models, Biological; D012038:Regeneration; D012984:Software