title: Cavum septum pellucidum in schizophrenia: a magnetic resonance imaging study.
abstract: In order to determine if cavum septum pellucidum (CSP) is more prevalent in schizophrenic patients, we studied 72 Japanese patients who fulfilled the DSM-III-R criteria for schizophrenia and 41 normal controls. Sagittal, 1 mm thick magnetic resonance imaging slices of the entire cranium were obtained using a gradient-echo pulse sequence, and coronal and axial images were reconstructed for assessment. A CSP was observed in 34 patients (47.2%) and in 16 controls (38.0%). Although the CSP appeared to be more prevalent in schizophrenic patients, this difference was not statistically significant. However, schizophrenic patients with a history of long-term institutionalization had a higher incidence of CSP compared with patients who had not been admitted to hospital for more than 3 years (68.2 vs 38.0%). These results suggest that the CSP may be a pathophysiology that characterizes schizophrenic patients with poor prognoses.
authors.affiliation: Department of Neuropsychiatry, Faculty of Medicine, Kagoshima University, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Fukuzako
authors.forename: H
authors.initials: H
authors.lastname: Fukuzako
authors.forename: S
authors.initials: S
authors.lastname: Kodama
authors.forename: T
authors.initials: T
authors.lastname: Hashiguchi
authors.forename: M
authors.initials: M
authors.lastname: Takigawa
mesh_terms: D000328:Adult; D017668:Age of Onset; D005260:Female; D007839:Functional Laterality; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000706:statistics & numerical data; D008297:Male; D015995:Prevalence; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000175:diagnosis* / Q000473:pathology; D012565:Schizophrenic Psychology; D012688:Septum Pellucidum / Q000002:abnormalities* / Q000473:pathology