title: [Large-cell carcinoma presenting as diffuse thickening of the pleura and resembling malignant mesothelioma].
abstract: A 65-year-old man had a right-sided pleural effusion. A thoracic CT scan revealed diffuse pleural thickening resembling malignant mesothelioma. Repeated needle biopsies did not yield a definitive diagnosis. At autopsy, diffuse pleural thickening was found, and examination of a specimen of lung tissue showed large-cell carcinoma. Hyalinized fibrous tissue with malignant cell infiltration was seen in the thickened pleural tissue and metastatic pleuritis was diagnosed. Large-cell carcinoma of the lung should be considered in the differential diagnosis of pleural thickening.
authors.affiliation: Fifth Department of Internal Medicine, Hyogo College of Medicine, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Nakamura
authors.forename: I
authors.initials: I
authors.lastname: Ikeda
authors.forename: H
authors.initials: H
authors.lastname: Nakahama
authors.forename: O
authors.initials: O
authors.lastname: Kitada
authors.forename: M
authors.initials: M
authors.lastname: Sugita
mesh_terms: D000368:Aged; D002289:Carcinoma, Non-Small-Cell Lung / Q000175:diagnosis*; D003937:Diagnosis, Differential; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis*; D008297:Male; D008654:Mesothelioma / Q000175:diagnosis*; D010994:Pleura / Q000473:pathology*; D016066:Pleural Effusion, Malignant / Q000209:etiology; D010997:Pleural Neoplasms / Q000175:diagnosis*