title: Pulsed photoacoustic spectroscopy applied to the diffusion of sunscreen chromophores in human skin: the weakly absorbent regime.
abstract: Pulsed photoacoustic spectroscopy was used to study the penetration of sunscreen chromophores into human skin. This study focuses on basic solutions containing single typical filter molecules, as used in current sunscreens, dissolved in mineral oil. The pulsed form of the photoacoustic technique was preferred because it provides more detailed information on the filter distribution within the different layers of human skin. A new methodology provides better insight into the diffusion process through signal analysis in the time and frequency domains, allowing for global and depth-related characterization. The penetration of the chromophore influences the response signal by inducing changes in the optical and thermal properties at different depths within the medium. The light scattering effect of titanium dioxide was demonstrated by the same technique.
authors.affiliation: Department of Chemistry, University of Miami, FL 33124-0431, USA.
authors.forename: G
authors.initials: G
authors.lastname: Puccetti
authors.forename: F
authors.initials: F
authors.lastname: Lahjomri
authors.forename: R M
authors.initials: RM
authors.lastname: Leblanc
mesh_terms: D000042:Absorption; D004058:Diffusion; D006801:Humans; D066298:In Vitro Techniques; D008027:Light; D012542:Scattering, Radiation; D012815:Signal Processing, Computer-Assisted; D012867:Skin / Q000378:metabolism*; D012996:Solutions; D017550:Spectroscopy, Fourier Transform Infrared; D013057:Spectrum Analysis; D013473:Sunscreening Agents / Q000493:pharmacokinetics*
chemical_list: D012996:Solutions; D013473:Sunscreening Agents