Nerve xenograft transplantation. Immunosuppression with FK-506 and RS-61443.
An experimental model has been developed to study the potential transplantation of nerve xenografts using the newer immunosuppressive agents RS-61443 and FK-506. Sciatic nerve grafts of 2 cm were transplanted from donor Golden Syrian hamsters into a 0.5 cm gap in the sciatic nerve of recipient Lewis rats. Walking track analysis, somatosensory evoked potentials and histology demonstrated improved regeneration across the nerve xenografts that had been immunosuppressed with RS-61443 and FK-506 compared with non-immunosuppressed controls, but the function never approached that seen in control isografts. Regeneration across nerve xenografts immunosuppressed with FK-506 was better than xenografts immunosuppressed with RS-61443.
Hebebrand
D
D
UCLA Hand Center, USA.
Zohman
G
G
Jones
N F
NF
D000818:Animals; D006224:Cricetinae; D006084:Graft Rejection / Q000276:immunology / Q000473:pathology; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D008647:Mesocricetus; D009173:Mycophenolic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D009416:Nerve Regeneration / Q000187:drug effects* / Q000276:immunology; D009431:Neural Conduction / Q000187:drug effects / Q000276:immunology; D010525:Peripheral Nerves / Q000276:immunology / Q000473:pathology / Q000637:transplantation*; D051381:Rats; D011917:Rats, Inbred Lew; D012584:Sciatic Nerve / Q000276:immunology / Q000473:pathology / Q000637:transplantation; D016559:Tacrolimus / Q000494:pharmacology*; D014183:Transplantation, Heterologous / Q000276:immunology / Q000473:pathology
D007166:Immunosuppressive Agents; D009173:Mycophenolic Acid; D016559:Tacrolimus