[Mast cells in a focus of carrageenan-induced acute aseptic inflammation].
On the model of carrageenen-induced acute aseptic peritonitis in rats the regularities of the functional state of mast cells (MC), of the content of free and cellular histamine in exudate and mesenterium and histamine in blood from the 5th minute up to 10th day after injection of phlogogene have been studied. Also as in infectious inflammation, the phasic reaction of MC which is observed at least during 10 days after action of phlogogene has been shown. The quick short first phase during half an hour after induction of inflammation has been observed and the gradual long second phase from the 1st hour up to 10th day has been noted. At least during 1st day the regularities of reaction of MC were extremely similar to the ones in infection peritonitis. Also as in infectious inflammation the second phase of reaction of MC correlates with the accumulation of leukocytes in inflammatory focus. At the same time the dependence of dynamics of functional changes of MC in aseptic inflammation on the properties of phlogogene (irritating or relatively indifferent phlogenes) has been established.
Klymenko
M O
MO
Pavlova
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D000208:Acute Disease; D000818:Animals; D002351:Carrageenan; D004195:Disease Models, Animal; D004927:Escherichia coli Infections / Q000378:metabolism / Q000473:pathology; D006632:Histamine / Q000378:metabolism; D008297:Male; D008407:Mast Cells / Q000378:metabolism / Q000473:pathology*; D010538:Peritonitis / Q000139:chemically induced / Q000378:metabolism / Q000473:pathology*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D006632:Histamine; D002351:Carrageenan