Prognostic value of Ki-67 for recurrence and progression of superficial bladder cancer.
OBJECTIVE
We retrospectively reviewed 104 cases of superficial bladder cancer to ascertain whether the Ki-67 labeling index predicts recurrence and progression.


METHODS
Archival specimens from superficial bladder cancer cases were immunostained with Ki-67.


RESULTS
The recurrence rate was significantly higher in cases with a Ki-67 labeling index of 5.35 or greater than in those with a value less than 5.35 (p < 0.001). The recurrence rate at 2 years was 70% in cases with a Ki-67 labeling index of 5.35 or greater and 22% in those with an index less than 5.35 (p < 0.001). Using multivariate analysis the index predicted recurrence of bladder cancer (p < 0.005). Median Ki-67 labeling index in cases with progression was significantly higher than in those without progression (p < 0.01).


CONCLUSIONS
The Ki-67 labeling index is an independent predictive factor for recurrence of superficial bladder cancer.
Asakura
T
T
Department of Urology, Yokohama City University School of Medicine, Japan.
Takano
Y
Y
Iki
M
M
Suwa
Y
Y
Noguchi
S
S
Kubota
Y
Y
Masuda
M
M
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002295:Carcinoma, Transitional Cell / Q000737:chemistry* / Q000453:epidemiology; D018450:Disease Progression; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D019394:Ki-67 Antigen / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology*; D011237:Predictive Value of Tests; D011379:Prognosis; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D001749:Urinary Bladder Neoplasms / Q000737:chemistry* / Q000453:epidemiology
D019394:Ki-67 Antigen