[Anaphylactic or anaphylactoid reactions to paracetamol. Report of 3 cases].
Anaphylaxis to paracetamol exists and perhaps nowadays diagnosis is not confined to clinical evidence of: The repeatability of clinical symptoms. Skin tests. Provocation tests. But also by immuno-biological evidence. Application of the test of Activation of basophils by Flow Cytometry and measurement of leukotriene C4 have been nowadays largely validated and constitute irrefutable proof of the responsibility of the drug as the origin of the clinical symptoms.
Sabbah
A
A
Laboratoire d'Immuno-Allergologie, CHU 4, Angers.
Sainte-Laudy
J
J
Drouet
M
M
Lauret
M G
MG
Loiry
M
M
D000082:Acetaminophen / Q000009:adverse effects*; D000328:Adult; D000707:Anaphylaxis / Q000139:chemically induced* / Q000175:diagnosis / Q000276:immunology; D015549:Basophil Degranulation Test; D015496:CD4-Positive T-Lymphocytes / Q000378:metabolism; D003875:Drug Eruptions / Q000209:etiology; D005260:Female; D006801:Humans; D017997:Leukotriene C4 / Q000378:metabolism; D008875:Middle Aged; D012882:Skin Tests; D014581:Urticaria / Q000139:chemically induced
D017997:Leukotriene C4; D000082:Acetaminophen