title: Chromosome abnormality in solid and cystic tumor of the pancreas.
abstract: We report a case of a solid and cystic tumor of the pancreas with chromosomal abnormalities. The patient, a 13-yr-old girl, successfully underwent surgical excision and has been asymptomatic for more than 10 months. The tumor had two parameters suggesting malignant potential; a local invasion into a bile duct, and high mitotic activity. Chromosomal analysis showed two complex abnormalities, of which double loss of X chromosomes and trisomy for chromosome 3 were common. The complexity and polyclonality may stem from a clonal evolution. The observed abnormalities may provide a crucial clue to the understanding of the developmental process of this neoplasm.
authors.affiliation: Department of Pediatrics, Nishi-Kobe Medical Center, Nishi-ku, Kobe, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Matsubara
authors.forename: H
authors.initials: H
authors.lastname: Nigami
authors.forename: H
authors.initials: H
authors.lastname: Harigaya
authors.forename: K
authors.initials: K
authors.lastname: Baba
mesh_terms: D000293:Adolescent; D002869:Chromosome Aberrations; D025063:Chromosome Disorders; D002893:Chromosomes, Human, Pair 3 / Q000235:genetics; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007150:Immunohistochemistry; D010181:Pancreatic Cyst / Q000235:genetics / Q000473:pathology; D010190:Pancreatic Neoplasms / Q000235:genetics* / Q000473:pathology* / Q000601:surgery; D012729:Sex Chromosome Aberrations / Q000235:genetics; D014314:Trisomy