Anti Candida activity of induced transferrin in mice immunized with inactivated Candida albicans.
Mice immunized with formalin-killed Candida albicans were resistant to challenge by a lethal amount of viable C. albicans. The growth-inhibitory activity to C. albicans was detected in sera from the immunized mice, and was inhibited by the addition of anti-transferrin antibody or ferric sulfate. Both the amount of transferrin and the unsaturated iron-binding capacity (UIBC) in the serum were significantly increased, indicating that apo-transferrin increased in the immunized mice. Moreover, the intraperitoneal administration of apo-transferrin enhanced the protection from the Candida infection in vivo.
Watanabe
T
T
Department of Microbiology, Tohoku College of Pharmacy, Sendai, Japan.
Tanaka
H
H
Nakao
N
N
Mikami
T
T
Suzuki
M
M
Matsumoto
T
T
D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology; D001059:Apoproteins / Q000494:pharmacology; D002176:Candida albicans / Q000254:growth & development* / Q000276:immunology; D002177:Candidiasis / Q000276:immunology / Q000517:prevention & control*; D007114:Immunization; D007501:Iron / Q000378:metabolism; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D014168:Transferrin / Q000096:biosynthesis* / Q000494:pharmacology
D000935:Antifungal Agents; D001059:Apoproteins; D014168:Transferrin; C028284:apotransferrin; D007501:Iron