title: The non-peptide tachykinin NK1- and NK2-receptor antagonists SR 140333 and SR 48968 prevent castor-oil induced diarrhea in rats.
abstract: Castrol-oil induced diarrhea in rats was potently prevented by compounds SR 140333 and SR 48968, the first a tachykinin NK1- and the second a NK2-receptor antagonist. SR 48968 was more effective and also reduced fecal water content.
authors.affiliation: Research Center SANOFI MIDY, Milan, Italy.
authors.forename: T
authors.initials: T
authors.lastname: Croci
authors.forename: X
authors.initials: X
authors.lastname: Emonds-Alt
authors.forename: G
authors.initials: G
authors.lastname: Le Fur
authors.forename: J P
authors.initials: JP
authors.lastname: Maffrand
authors.forename: L
authors.initials: L
authors.lastname: Manara
mesh_terms: D000818:Animals; D001549:Benzamides / Q000494:pharmacology*; D002368:Castor Oil; D003967:Diarrhea / Q000139:chemically induced* / Q000517:prevention & control*; D004305:Dose-Response Relationship, Drug; D008297:Male; D064729:Neurokinin-1 Receptor Antagonists; D010880:Piperidines / Q000494:pharmacology*; D011812:Quinuclidines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D018041:Receptors, Neurokinin-2 / Q000037:antagonists & inhibitors*
chemical_list: D001549:Benzamides; D064729:Neurokinin-1 Receptor Antagonists; D010880:Piperidines; D011812:Quinuclidines; D018041:Receptors, Neurokinin-2; C085215:SR 140333; C073839:SR 48968; D002368:Castor Oil