Pathways leading to cell death in T cells.
Antigen-induced apoptosis of T cells is a highly regulated process which plays a key role in the elimination of self-reactive T cells and, thus, in the prevention of autoimmunity. It has recently become apparent that members of the tumor necrosis factor (TNF) and TNF receptor (TNFR) superfamily regulate antigen-induced T-cell death. Studies characterizing genes which control TNF/TNFR superfamily expression and how TNF/TNFR signal transducers activate cell death machinery, such as caspases, have begun to reveal the molecular control of antigen-induced T-cell death.
Wong
B
B
Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, Box 295, New York, NY 10021, USA. wongb@rockvax.rockefeller.edu
Choi
Y
Y
D000818:Animals; D017209:Apoptosis / Q000276:immunology*; D006801:Humans; D015398:Signal Transduction / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology* / Q000473:pathology