title: Issues in the comparison of risk estimates for the population in the Techa River region and atomic bomb survivors.
abstract: Plutonium production in the former Soviet Union began in 1949 at the Mayak Production Association located between the cities of Chelyabinsk and Ekaterinbourg in the southern Ural mountains about 1200 km east to Moscow. During the first few years of Mayak's operation, almost 30,000 people living on the banks of the Techa River received significant internal and external exposures as a consequence of the release of large quantities of radioactive materials from Mayak. Studies of levels of radioactive contamination and health effects in this population began in the early 1950s. A systematic follow-up of a fixed cohort that includes all people who were living in Techa River villages in 1949 was begun about 30 years ago. In this paper we describe the Techa River cohort, outline the nature of the exposures and discuss the status of follow-up for the period from 1950 through 1989. While noting the limitations of the current epidemiological follow-up data, we also compare the demographic and mortality structure of the Techa River cohort with the Life Span Study cohort of Japanese atomic bomb survivors. It is seen that, despite a number of limitations, the current data suggest that the risks of mortality from leukemia and other cancers increase with increasing radiation dose in the Techa River cohort. This finding suggests that, with continued improvements in the quality of the follow-up and dosimetry, the Techa River cohort has the potential to provide quantitative estimates of the risks of chronic low-dose-rate radiation exposures for an unselected general population that will be an important complement to the estimates based on the Life Span Study that are used as the primary basis for numerical assessments of radiation risk.
authors.affiliation: Department of Epidemiology, Urals Research Center for Radiation Medicine, Medgorodok, Russian Federation.
authors.forename: M M
authors.initials: MM
authors.lastname: Kossenko
authors.forename: M O
authors.initials: MO
authors.lastname: Degteva
authors.forename: O V
authors.initials: OV
authors.lastname: Vyushkova
authors.forename: D L
authors.initials: DL
authors.lastname: Preston
authors.forename: K
authors.initials: K
authors.lastname: Mabuchi
authors.forename: V P
authors.initials: VP
authors.lastname: Kozheurov
mesh_terms: D004781:Environmental Exposure; D005260:Female; D006801:Humans; D007953:Leukemia, Radiation-Induced / Q000453:epidemiology; D008297:Male; D009381:Neoplasms, Radiation-Induced / Q000453:epidemiology / Q000209:etiology* / Q000401:mortality; D009689:Nuclear Warfare; D011005:Plutonium / Q000633:toxicity*; D018788:Radioactive Hazard Release; D018570:Risk Assessment; D012426:Russia; D012737:Sex Factors; D014875:Water Pollutants, Radioactive / Q000633:toxicity*
chemical_list: D014875:Water Pollutants, Radioactive; D011005:Plutonium