title: Bioactive alkaloids from Illigera luzonensis.
abstract: Using antiplatelet aggregation as a guide to fractionation, seven aporphines, actinodaphnine (1), N-methylactinodaphnine (2), launobine (3), dicentrine (4), O-methylbulbocapnine (5), hernovine (7), and bulbocapnine (9), and two oxoaporphines, dicentrinone (6) and liriodenine (8), were isolated from the stems of Illigera luzonensis. Among them, compounds 2, 4, 5, 8, and 9 were isolated for the first time from this species. Moreover, compounds 1-5, and 8 showed significant antiplatelet aggregation and compounds 1 and 6 exhibited significant vasorelaxant activities, respectively.
authors.affiliation: Ta-Jen Pharmaceutical Junior College, Taiwan, Republic of China.
authors.forename: K S
authors.initials: KS
authors.lastname: Chen
authors.forename: Y C
authors.initials: YC
authors.lastname: Wu
authors.forename: C M
authors.initials: CM
authors.lastname: Teng
authors.forename: F N
authors.initials: FN
authors.lastname: Ko
authors.forename: T S
authors.initials: TS
authors.lastname: Wu
mesh_terms: D000470:Alkaloids / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D010975:Platelet Aggregation Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology; D011817:Rabbits; D051381:Rats
chemical_list: D000470:Alkaloids; D010975:Platelet Aggregation Inhibitors