title: Severe radiation-induced liver disease following localized radiation therapy for biliopancreatic carcinoma: activation of hepatic stellate cells as an early event.
abstract: Radiation-induced liver disease is recorded as a form of veno-occlusive disease. Its pathogenesis remains unclear even if the initial injury likely occurs in the endothelial cells of central veins. The aim of our study was to investigate liver morphological features in relation to alpha-isoform of smooth muscle actin expression in hepatic stellate cells in six patients treated by localized radiotherapy on the biliopancreatic area. Within the month after completion of treatment, an activation of hepatic stellate cells strictly confined to irradiated areas and coinciding with congestive changes was observed. At a later stage, collagen deposition gradually increased, replacing the congestive and destroyed areas. This new fibrotic tissue also contained numerous alpha-smooth muscle positive cells. Our data suggest that early hepatic stellate cells activation coinciding with congestive changes plays an important role in radiation liver injury and ensuing fibrosis.
authors.affiliation: Department of Pathology, University Hospital St-Luc, Louvain Medical School, Brussels, Belgium.
authors.forename: C
authors.initials: C
authors.lastname: Sempoux
authors.forename: Y
authors.initials: Y
authors.lastname: Horsmans
authors.forename: A
authors.initials: A
authors.lastname: Geubel
authors.forename: J
authors.initials: J
authors.lastname: Fraikin
authors.forename: B E
authors.initials: BE
authors.lastname: Van Beers
authors.forename: J F
authors.initials: JF
authors.lastname: Gigot
authors.forename: J
authors.initials: J
authors.lastname: Lerut
authors.forename: J
authors.initials: J
authors.lastname: Rahier
mesh_terms: D000199:Actins / Q000378:metabolism*; D000328:Adult; D000368:Aged; D001650:Bile Duct Neoplasms / Q000150:complications / Q000532:radiotherapy*; D001706:Biopsy; D005260:Female; D006801:Humans; D008099:Liver / Q000378:metabolism* / Q000473:pathology / Q000528:radiation effects*; D008107:Liver Diseases / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000150:complications / Q000532:radiotherapy*; D011832:Radiation Injuries / Q000209:etiology* / Q000473:pathology; D011878:Radiotherapy / Q000009:adverse effects
chemical_list: D000199:Actins