title: Late effects of therapy in survivors of Ewing's sarcoma family tumors.
abstract: OBJECTIVE
  This late effects study was designed to determine if survivors of Ewing's sarcoma family tumors (ESFT) had adverse outcomes in employment, marital status, fertility, and functional status when compared to sibling controls.
  
  
  METHODS
  Eighty-nine survivors (case subjects) of ESFT treated at the National Cancer Institute between 1965 and 1992 and 97 sibling controls completed a questionnaire probing aspects of quality of life. The answers from case subjects were compared to pooled and matched sibling controls for all key variables. Odds ratios (OR) and p values from pooled analyses are presented.
  
  
  RESULTS
  Although case subjects and controls did not differ in educational achievement, case subjects were less likely to be employed full-time (OR 0.4, p < 0.01), to be married (OR 0.2, p < 0.01), and to have children (OR 0.3, p < 0.01). Their most common treatment-related difficulties included permanent hair and skin changes (43%), lung problems (18%), neurologic problems (14%), visual difficulties (10%), second malignancy (7%), and amputation (5%). Functional status, measured by Karnofsky performance scale, was also adversely affected in case subjects. Case subjects did not differ from sibling controls in health care insurance status or in utilization of health services.
  
  
  CONCLUSIONS
  Important aspects of life such as employment, marital status, fertility, and functional status are affected in survivors of ESFT. More studies are needed to better define the health status of adult survivors of pediatric cancer and the impact of cancer in adolescence on psychosocial development.
authors.affiliation: Genetic Epidemiology Branch, National Cancer Institute, Bethesda, Maryland, USA.
authors.forename: B
authors.initials: B
authors.lastname: Novakovic
authors.forename: T R
authors.initials: TR
authors.lastname: Fears
authors.forename: M E
authors.initials: ME
authors.lastname: Horowitz
authors.forename: M A
authors.initials: MA
authors.lastname: Tucker
authors.forename: L H
authors.initials: LH
authors.lastname: Wexler
mesh_terms: D000293:Adolescent; D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001859:Bone Neoplasms / Q000188:drug therapy / Q000532:radiotherapy; D016022:Case-Control Studies; D002648:Child; D004522:Educational Status; D004651:Employment; D005260:Female; D005298:Fertility; D006304:Health Status; D006801:Humans; D017567:Karnofsky Performance Status; D008297:Male; D017533:Marital Status; D008875:Middle Aged; D012512:Sarcoma, Ewing / Q000188:drug therapy / Q000532:radiotherapy; D017741:Survivors; D013997:Time Factors
chemical_list: D000970:Antineoplastic Agents