Use of hepatocyte cultures for the study of hepatotoxic compounds.
Human and animal hepatocytes in primary culture are widely used in pharmacotoxicological research. They represent a unique in vitro model since they retain both phase I and phase II enzyme activities as well as their inducibility by xenobiotics. Hepatocyte cultures are used for drug screening, identification of the lesions induced by toxic compounds and determination of mechanisms by which xenobiotics exert liver injury.
Guillouzo
A
A
INSERM U 49, Unité de Recherches Hépatologiques, Hôpital Pontchaillou, Rennes, France.
Morel
F
F
Langouët
S
S
Maheo
K
K
Rissel
M
M
D000818:Animals; D002469:Cell Separation; D002478:Cells, Cultured; D006801:Humans; D008099:Liver / Q000187:drug effects* / Q000473:pathology