title: A simple method for 3D lesion reconstruction from two projected angiographic images: implementation to a stereotactic radiotherapy treatment planning system.
abstract: BACKGROUND
  The most used imaging modality for diagnosis and localisation of arteriovenous malformations (AVMs) treated with stereotactic radiotherapy is angiography. The fact that the angiographic images are projected images imposes the need of the 3D reconstruction of the lesion. This, together with the 3D head anatomy from CT images could provide all the necessary information for stereotactic treatment planning. We have developed a method to combine the complementary information provided by angiography and 2D computerized tomography, matching the reconstructed AVM structure with the reconstructed head of the patient.
  
  
  METHODS
  The ISIS treatment planning system, developed at Institute Curie, has been used for image acquisition, stereotactic localisation and 3D visualisation. A series of CT slices are introduced in the system as well as two orthogonal angiographic projected images of the lesion. A simple computer program has been developed for the 3D reconstruction of the lesion and for the superposition of the target contour on the CT slices of the head.
  
  
  CONCLUSIONS
  In our approach we consider that the reconstruction can be made if the AVM is approximated with a number of adjacent ellipses. We assessed the method comparing the values of the reconstructed and the actual volumes of the target using linear regression analysis. For treatment planning purposes we overlapped the reconstructed AVM on the CT slices of the head. The above feature is to our knowledge a feature that the majority of the commercial stereotactic radiotherapy treatment planning system could not provide. The implementation of the method into ISIS TPS shows that we can reliably approximate and visualize the target volume.
authors.affiliation: Medical Physics Department, Medical School, University of Patras, Greece.
authors.forename: K
authors.initials: K
authors.lastname: Theodorou
authors.forename: C
authors.initials: C
authors.lastname: Kappas
authors.forename: G
authors.initials: G
authors.lastname: Gaboriaud
authors.forename: A D
authors.initials: AD
authors.lastname: Mazal
authors.forename: O
authors.initials: O
authors.lastname: Petrascu
authors.forename: J C
authors.initials: JC
authors.lastname: Rosenwald
mesh_terms: D002533:Cerebral Angiography / Q000379:methods*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D002538:Intracranial Arteriovenous Malformations / Q000175:diagnosis* / Q000532:radiotherapy*; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*; D012044:Regression Analysis