Tityustoxin-induced release of ATP from rat brain cortical synaptosomes.
Tityustoxin, a scorpion toxin that alters the Na+ channel activity, induces release of ATP from rat brain cortical synaptosomes. The effect of tityustoxin is dependent on its concentration and incubation time. Continuously or cumulative release of ATP evoked by tityustoxin was calcium-dependent and interestingly only partially inhibited by tetrodotoxin. We suggest that tityustoxin mainly releases ATP from the vesicular pool but other pools may also be involved.
Salgado
A H
AH
Departamento de Fisiologia e Biofisica, Faculdade de Farmácia, -UFMG, Minas Gerais, Brazil.
Prado
M A
MA
Moraes-Santos
T
T
Romano-Silva
M A
MA
Gomez
M V
MV
D000255:Adenosine Triphosphate / Q000378:metabolism*; D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects* / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D009498:Neurotoxins / Q000494:pharmacology*; D051381:Rats; D012604:Scorpion Venoms / Q000494:pharmacology*; D013574:Synaptosomes / Q000187:drug effects* / Q000378:metabolism
D009498:Neurotoxins; D012604:Scorpion Venoms; C003609:tityustoxin; D000255:Adenosine Triphosphate