Effects of repeated injections of palytoxin on lymphoid tissues in mice.
Sublethal doses of palytoxin were i.p. injected repeatedly to mice, and the effects on lymphoid tissues were examined. The weight and morphology of the thymus were influenced during exposure but had generally recovered after 1 month of withdrawal. The ratio of lymphocytes to total leukocytes in blood was decreased during the injection term, and did not recover to a normal level even after 1 month of withdrawal. The component of B-cells in the lymphocytes was clarified as being responsible for the small number of lymphocytes in the recovery process.
Ito
E
E
Research Center for Pathogenic, Fungi and Microbial Toxicoses, Chiba University, Japan.
Ohkusu
M
M
Terao
K
K
Yasumoto
T
T
D000178:Acrylamides / Q000008:administration & dosage / Q000633:toxicity*; D000818:Animals; D003386:Brachyura; D003064:Cnidarian Venoms / Q000008:administration & dosage / Q000633:toxicity*; D005434:Flow Cytometry; D007274:Injections, Intraperitoneal; D018655:Lymphocyte Count; D008221:Lymphoid Tissue / Q000187:drug effects* / Q000473:pathology; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009929:Organ Size / Q000187:drug effects; D013154:Spleen / Q000187:drug effects / Q000473:pathology; D013950:Thymus Gland / Q000187:drug effects / Q000473:pathology; D000095702:Polyether Toxins
D000178:Acrylamides; D003064:Cnidarian Venoms; C010272:palytoxin; D000095702:Polyether Toxins