High-dose methylprednisolone-induced dramatic maturation of granulocytes in idiopathic chronic neutropenia.
Idiopathic chronic neutropenia is characterized by a variable pattern of age at the onset of neutropenia, neutrophil counts, maturational arrest at the promyelocyte/myelocyte stage in the bone marrow, and recurrent pyogenic infections without any underlying disease or drug administration. There have been reports of lack of response to conventional-dose steroid therapy, but in recent studies it has been shown that high-dose corticosteroids are effective in several neutropenic states. Here we report an apparent response to high-dose methylprednisolone in a patient with idiopathic chronic neutropenia.
Yetgin
S
S
Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara.
Ozbek
N
N
D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D002675:Child, Preschool; D002908:Chronic Disease; D004305:Dose-Response Relationship, Drug; D016903:Drug Monitoring; D006098:Granulocytes / Q000187:drug effects; D006801:Humans; D007958:Leukocyte Count / Q000187:drug effects; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use*; D009503:Neutropenia / Q000188:drug therapy*
D000893:Anti-Inflammatory Agents; D008775:Methylprednisolone