title: Recruiting the 2-5A system for antisense therapeutics.
authors.affiliation: Section on Biomedical Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-0805, USA.
authors.forename: P F
authors.initials: PF
authors.lastname: Torrence
authors.forename: W
authors.initials: W
authors.lastname: Xiao
authors.forename: G
authors.initials: G
authors.lastname: Li
authors.forename: H
authors.initials: H
authors.lastname: Cramer
authors.forename: M R
authors.initials: MR
authors.lastname: Player
authors.forename: R H
authors.initials: RH
authors.lastname: Silverman
mesh_terms: D000227:Adenine Nucleotides / Q000378:metabolism* / Q000494:pharmacology; D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology; D001692:Biological Transport; D017076:Computer-Aided Design; D015195:Drug Design; D004722:Endoribonucleases / Q000378:metabolism*; D004789:Enzyme Activation / Q000187:drug effects; D006801:Humans; D046911:Macromolecular Substances; D016376:Oligonucleotides, Antisense / Q000737:chemistry / Q000493:pharmacokinetics / Q000627:therapeutic use*; D009843:Oligoribonucleotides / Q000378:metabolism* / Q000494:pharmacology; D009994:Osmolar Concentration; D012333:RNA, Messenger / Q000378:metabolism; D012367:RNA, Viral / Q000037:antagonists & inhibitors / Q000235:genetics; D012136:Respiratory Syncytial Viruses / Q000187:drug effects / Q000235:genetics
chemical_list: D000227:Adenine Nucleotides; D000998:Antiviral Agents; D046911:Macromolecular Substances; D016376:Oligonucleotides, Antisense; D009843:Oligoribonucleotides; D012333:RNA, Messenger; D012367:RNA, Viral; C023505:2',5'-oligoadenylate; D004722:Endoribonucleases; C031956:2-5A-dependent ribonuclease