title: BCL6 rearrangement in a patient with mantle cell lymphoma.
abstract: We describe a patient with mantle cell lymphoma (MCL) associated with BCL6 gene rearrangement. MCL is a distinct subtype of non-Hodgkin's lymphoma characterized by CD5+, CD10-, CD20+, t(11;14)(q13;q32) and PRAD1/cyclin D1 overexpression. Although rearrangement of the BCL6 gene is the most frequent genetic change among diffuse lymphomas and some follicular lymphomas this is the first report of a patient with MCL associated with BCL6 rearrangement.
authors.affiliation: Third Department of Internal Medicine, Akita University School of Medicine, Japan.
authors.forename: I
authors.initials: I
authors.lastname: Miura
authors.forename: A
authors.initials: A
authors.lastname: Ohshima
authors.forename: A
authors.initials: A
authors.lastname: Chubachi
authors.forename: T
authors.initials: T
authors.lastname: Nimura
authors.forename: A
authors.initials: A
authors.lastname: Komatsuda
authors.forename: S
authors.initials: S
authors.lastname: Utsumi
authors.forename: M
authors.initials: M
authors.lastname: Saito
authors.forename: T
authors.initials: T
authors.lastname: Machii
authors.forename: S
authors.initials: S
authors.lastname: Nakamura
authors.forename: M
authors.initials: M
authors.lastname: Seto
authors.forename: A B
authors.initials: AB
authors.lastname: Miura
mesh_terms: D000368:Aged; D002880:Chromosomes, Human, Pair 11; D002883:Chromosomes, Human, Pair 14; D019938:Cyclin D1; D016213:Cyclins / Q000235:genetics; D004268:DNA-Binding Proteins / Q000235:genetics*; D015322:Gene Rearrangement, B-Lymphocyte; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000235:genetics*; D008297:Male; D015513:Oncogene Proteins / Q000235:genetics; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D051560:Proto-Oncogene Proteins c-bcl-6; D014157:Transcription Factors / Q000235:genetics*; D014178:Translocation, Genetic; D016335:Zinc Fingers
chemical_list: D016213:Cyclins; D004268:DNA-Binding Proteins; D015513:Oncogene Proteins; D011518:Proto-Oncogene Proteins; D051560:Proto-Oncogene Proteins c-bcl-6; D014157:Transcription Factors; D019938:Cyclin D1