Effect of a commercial disinfectant ('Virkon') on mouse experimental infection by Cryptosporidium parvum.
Cryptosporidium parvum oocysts obtained from naturally-infected calves were exposed to 1-10% 'Virkon' for 10-360 min, then inoculated intragastrically into coccidium-free neonatal mice. Prevalence and intensity of infection were determined seven days later by examination of intestinal homogenates. Although we were unable to abolish infectivity for the mice, the intensity of infection was considerably reduced after long periods of exposure (up to > 90%, depending on disinfectant concentration), indicating that this product may have some value for disinfection when extended exposure is possible (e.g., soaking laboratory glassware).
Ares-Mazás
E
E
Department of Microbiology and Parasitology, Faculty of Pharmacy, University of Santiago de Compostela, La Coruña, Spain.
Lorenzo
M J
MJ
Casal
J A
JA
Fernández da Ponte
B
B
Castro
J A
JA
Freire
F
F
D000704:Analysis of Variance; D000818:Animals; D003457:Cryptosporidiosis / Q000517:prevention & control*; D016785:Cryptosporidium parvum / Q000187:drug effects*; D004202:Disinfectants / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D051379:Mice; D010545:Peroxides / Q000494:pharmacology*; D018709:Statistics, Nonparametric; D013464:Sulfuric Acids / Q000494:pharmacology*
D004202:Disinfectants; D010545:Peroxides; D013464:Sulfuric Acids; C071517:monoperoxysulfate