title: Peripheral neuropathy in acrodermatitis chronica atrophicans - a late Borrelia manifestation.
abstract: Clinical and/or neurophysiological signs of peripheral neuropathy were found in 64% of 63 consecutive untreated patients with the late borrelial manifestation acrodermatitis chronica atrophicans (ACA). The neuropathy frequency was significantly higher in the patients than in 30 age- and sex-matched control persons of whom 27% had neuropathy findings. The most common neuropathy in ACA was a symmetric distal sensory polyneuropathy. In a subgroup of patients with localized or asymmetric neuropathy, the changes were found more often in extremities with than without visible ACA lesions. Neuropathy symptoms, most often pain and/or paresthesia, were present in 64% of the patients, compared to in 13% of the control persons. Thus, both symptoms and signs of neuropathy were significantly more frequent in patients with untreated ACA than in control subjects.
authors.affiliation: Karolinska Institute, Department of Neurology, Stockholm Söder Hospital, Sweden.
authors.forename: E
authors.initials: E
authors.lastname: Kindstrand
authors.forename: B Y
authors.initials: BY
authors.lastname: Nilsson
authors.forename: A
authors.initials: A
authors.lastname: Hovmark
authors.forename: R
authors.initials: R
authors.lastname: Pirskanen
authors.forename: E
authors.initials: E
authors.lastname: Asbrink
mesh_terms: D000169:Acrodermatitis / Q000453:epidemiology* / Q000382:microbiology / Q000473:pathology; D000328:Adult; D000367:Age Factors; D000368:Aged; D015748:Borrelia burgdorferi Group / Q000302:isolation & purification; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D015897:Comorbidity; D005121:Extremities / Q000473:pathology / Q000503:physiopathology; D005260:Female; D006801:Humans; D006930:Hyperalgesia / Q000473:pathology / Q000503:physiopathology; D006987:Hypesthesia / Q000473:pathology / Q000503:physiopathology; D008193:Lyme Disease / Q000150:complications*; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000145:classification / Q000473:pathology / Q000503:physiopathology; D010292:Paresthesia / Q000473:pathology / Q000503:physiopathology; D010523:Peripheral Nervous System Diseases / Q000453:epidemiology* / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D015995:Prevalence; D011446:Prospective Studies; D012307:Risk Factors; D012737:Sex Factors; D013548:Sweden / Q000453:epidemiology