rho-Aminophenylalanine6 angiotensin II (AII) improves learning and memory in rats.
All and rho-aminophenylalanine6 angiotensin II, given i.c.v. (1 nmol) enhanced memory and stereotypic behaviour leaving gross motor activity unchanged. Both peptides showed also some anxiogenic action.
Braszko
J J
JJ
Clinical Pharmacology Unit, Medical Academy of Białystok, Poland.
Lotowska
A
A
Karwowska-Polecka
W
W
Wiśniewski
K
K
D000804:Angiotensin II / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D001522:Behavior, Animal / Q000187:drug effects; D007276:Injections, Intraventricular; D007858:Learning / Q000187:drug effects*; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D008568:Memory / Q000187:drug effects*; D011939:Mental Recall / Q000187:drug effects; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D013239:Stereotyped Behavior / Q000187:drug effects
D000804:Angiotensin II; C064745:angiotensin II, 4-amino-Phe(6)-