Receptor tyrosine kinases involved in hematopoietic progenitor cells.
To analyze the molecular mechanisms of the proliferation and differentiation of hematopoietic cells, we have cloned PTKs from sorted stem cells. We discuss the expression and function of receptor tyrosine kinases, STK/RON, TIE, TEK and HTK which have been cloned from these cells. STK and its ligand, MSP contributed to the motility and phagocytosis of peritoneal macrophages and bone absorption of osteoclasts. Apoptosis was induced in an erythroid cell line by the binding of MSP(MacrophageStimulating Protein). TIE, TEK and HTK were interestingly expressed in the subpopulations of stem cells and related to the myeloid differentiation. These study will indicate the heterogeneity of stem cells and their diverse differentiation.
Suda
T
T
Department of Cell Differentiation, Kumamoto University School of Medicine, Japan.
Iwama
A
A
Hashiyama
M
M
Sakano
S
S
Ohno
M
M
D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D001862:Bone Resorption; D002454:Cell Differentiation; D002455:Cell Division; D002465:Cell Movement; D003001:Cloning, Molecular; D003114:Colony-Forming Units Assay; D006133:Growth Substances / Q000494:pharmacology; D006412:Hematopoietic Stem Cells / Q000166:cytology* / Q000201:enzymology*; D017228:Hepatocyte Growth Factor; D017737:Macrophages, Peritoneal / Q000166:cytology / Q000187:drug effects / Q000502:physiology; D051379:Mice; D010010:Osteoclasts / Q000502:physiology; D010587:Phagocytosis; D011518:Proto-Oncogene Proteins; D020794:Receptor Protein-Tyrosine Kinases / Q000378:metabolism*; D036224:Receptor, EphB4; D042787:Receptor, TIE-2; D011956:Receptors, Cell Surface / Q000378:metabolism; D042764:Receptors, TIE; D011994:Recombinant Proteins / Q000378:metabolism
D006133:Growth Substances; D011518:Proto-Oncogene Proteins; D011956:Receptors, Cell Surface; D011994:Recombinant Proteins; C082332:macrophage stimulating protein; D017228:Hepatocyte Growth Factor; C080835:RON protein; D020794:Receptor Protein-Tyrosine Kinases; D036224:Receptor, EphB4; D042787:Receptor, TIE-2; D042764:Receptors, TIE