Sympathetic nerve traffic correlates with the release of nitric oxide in humans: implications for blood pressure control.
1. Resting human sympathetic vasoconstrictor traffic displays large reproducible inter-individual differences which are similar in nerves to muscle, heart and kidney. In spite of this there is no correlation between levels of blood pressure and sympathetic traffic. To test the hypothesis that the pressor effect of the vasoconstrictor activity is counteracted by a circulating dilating factor we measured muscle nerve sympathetic activity (MSA) and an indicator of nitric oxide release (plasma nitrate) in healthy young males. 2. Sympathetic activity was recorded with the microneurographic technique in the peroneal nerve and a forearm venous plasma sample was obtained in twenty-one normotensive males aged 21-28 years. Plasma nitrate was analysed by gas chromatography and mass spectrometry. 3. There was a positive linear correlation between the plasma nitrate concentration and the strength of MSA both when the nerve activity was expressed as bursts per minute and bursts per 100 heart beats (r = 0.51, P = 0.02 and r = 0.46, P = 0.04, respectively). 4. The data suggest that the stronger the sympathetic activity the higher the release of the dilating substance, nitric oxide. This would be expected to counteract vasoconstrictor effects of the nerve traffic and thereby contribute to the lack of relationship between resting levels of MSA and blood pressure. We speculate that altered coupling between sympathetic traffic and nitric oxide release may cause abnormal peripheral resistance, e.g. in hypertension.
Skarphedinsson
J O
JO
Department of Clinical Neurophysiology, Sahlgrenska University Hospital, Göteborg University, Sweden.
Elam
M
M
Jungersten
L
L
Wallin
B G
BG
D000328:Adult; D001794:Blood Pressure / Q000502:physiology*; D006801:Humans; D008297:Male; D008955:Models, Cardiovascular; D008959:Models, Neurological; D009566:Nitrates / Q000097:blood; D009569:Nitric Oxide / Q000502:physiology*; D013564:Sympathetic Nervous System / Q000502:physiology*; D014661:Vasoconstriction / Q000502:physiology*
D009566:Nitrates; D009569:Nitric Oxide