[Rapid induction of hepatic acetyl-CoA carboxylase activity after estradiol benzoate injection in the quail].
The time course of hepatic Acetyl-CoA carboxylase activity as well as hepatic and plasmatic fatty acids concentrations following a single injection of estradiol benzoate (EB, 0.2 mg/kg) was studied in the quail. Acetyl-CoA carboxylase activity increases rapidly and reaches its peak 3 h after the injection of EB. Similarly, hepatic and plasmatic fatty acids concentrations are significantly increased 6 h after the hormonal injection and attain their highest level 18 h later. These results suggest that estrogen affects the hepatic fatty acids biosynthesis by regulating the conversion of acetyl-CoA to malonyl-CoA.
Pageaux
J F
JF
Laboratoire de Chimie Biologique, Institut National des Sciences Appliquées de Lyon, Villeurbanne, France.
Laugier
C
C
Pacheco
H
H
D000105:Acetyl Coenzyme A / Q000378:metabolism; D000103:Acetyl-CoA Carboxylase / Q000096:biosynthesis*; D000818:Animals; D003370:Coturnix; D004790:Enzyme Induction / Q000187:drug effects; D004958:Estradiol / Q000494:pharmacology*; D005227:Fatty Acids / Q000097:blood / Q000378:metabolism; D007700:Kinetics; D008099:Liver / Q000201:enzymology*; D008316:Malonyl Coenzyme A / Q000378:metabolism
D005227:Fatty Acids; D004958:Estradiol; D008316:Malonyl Coenzyme A; D000105:Acetyl Coenzyme A; D000103:Acetyl-CoA Carboxylase