Influence of the Gloeophyllum metabolite oosponol and some synthetic analogues on protein and RNA synthesis in target cells.
Oosponol [4-(hydroxyacetyl)-8-hydroxy-1H-2-benzopyran-1-one], a toxic metabolite of the basidiomycete Gloeophyllum abietinum, and some synthetic analogues were studied to clarify the molecular basis of their fungicidal, bactericidal, and phytotoxic effects. The antibiotic activity was due to a strong inhibition of RNA and protein synthesis in target cells.
Sonnenbichler
J
J
Max-Planck-Institut für Biochemie, Martinsried, Germany.
Kovács
T
T
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001487:Basidiomycota / Q000737:chemistry; D002467:Cell Nucleus / Q000187:drug effects / Q000378:metabolism; D003374:Coumarins / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects / Q000378:metabolism; D007930:Leucine / Q000378:metabolism; D015394:Molecular Structure; D010940:Plant Proteins / Q000096:biosynthesis; D010944:Plants / Q000187:drug effects / Q000378:metabolism; D014176:Protein Biosynthesis; D011523:Protoplasts / Q000187:drug effects / Q000378:metabolism; D012313:RNA / Q000096:biosynthesis*; D018749:RNA, Plant / Q000096:biosynthesis; D014158:Transcription, Genetic / Q000187:drug effects
D000900:Anti-Bacterial Agents; D003374:Coumarins; D010940:Plant Proteins; D018749:RNA, Plant; C002774:oosponol; D012313:RNA; D007930:Leucine