title: Effect of abnormal sperm head morphology on the outcome of intracytoplasmic sperm injection in humans.
abstract: The present study was designed to determine the efficacy of intracytoplasmic sperm injection (ICSI) using spermatozoa with abnormal head morphology in 17 cases with total teratozoospermia. A total of 160 oocytes were retrieved and 144 metaphase II oocytes were injected. The fertilization and cleavage rates were 50.7 and 93.2% respectively. Fertilization failure occurred in two couples. A total of 54 embryos were transferred and pregnancy rates per initiated and per embryo transfer cycle were 17.6 and 20.0% respectively, while the clinical pregnancy rates per initiated and embryo transfer cycle were 11.8 and 13.3%. The implantation rate was 3.7% (2/54). Out of two pregnancies achieved, one resulted in abortion in the first trimester. The ongoing pregnancy rates per initiated and embryo transfer cycle were 5.88% (1/17) and 6.6% (1/15) respectively. Although the implantation and ongoing pregnancy rates are very low, ICSI seems to be the only treatment modality in cases where teratozoospermia was total with 100% abnormal head morphology.
authors.affiliation: Metropol Florence Nightingale, Department of Obstetrics and Gynecology, Istanbul, Turkey.
authors.forename: I
authors.initials: I
authors.lastname: Taşdemir
authors.forename: M
authors.initials: M
authors.lastname: Taşdemir
authors.forename: S
authors.initials: S
authors.lastname: Tavukçuoglu
authors.forename: S
authors.initials: S
authors.lastname: Kahraman
authors.forename: K
authors.initials: K
authors.lastname: Biberoģlu
mesh_terms: D000328:Adult; D003593:Cytoplasm; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods*; D006801:Humans; D007248:Infertility, Male / Q000473:pathology* / Q000628:therapy*; D008297:Male; D008845:Microinjections; D011247:Pregnancy; D013077:Sperm Head / Q000473:pathology*; D013094:Spermatozoa / Q000002:abnormalities*; D016896:Treatment Outcome