title: A histopathologic study of localized portal hypertension as a consequence of chronic pancreatitis.
abstract: OBJECTIVE
  To evaluate the mechanism of localized portal hypertension associated with stenosis or obstruction of the splenic vein in chronic alcoholic pancreatitis.
  
  
  METHODS
  Surgical and autopsy specimens from 12 patients with clinically diagnosed chronic alcoholic pancreatitis were examined histopathologically. Autopsy specimens of 10 normal pancreases served as control tissues.
  
  
  RESULTS
  In tissues from 11 of the 12 patients with chronic-alcoholic pancreatitis, fibrosis in the pancreatic parenchyma continuously extended to the wall of the splenic vein; organized thrombus formation with recanalization was found in five patients, phlebosclerosis in four, and no changes were found in two. In two of the five patients with organized thrombus formation in the splenic vein, localized portal hypertension had been clinically diagnosed because of splenomegaly and varicose veins in the fundus of the stomach, but it was not accompanied by liver cirrhosis. In the control tissues, fibrosis was not observed in the peripancreatic tissue or the area surrounding the wall of the splenic vein.
  
  
  CONCLUSIONS
  We regard localized portal hypertension due to stenosis or obstruction of the splenic vein as one of the consequences of peripancreatic fibrosis in chronic alcoholic pancreatitis.
authors.affiliation: Department of Pathology, Juntendo University School of Medicine, Tokyo, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Takase
authors.forename: K
authors.initials: K
authors.lastname: Suda
authors.forename: F
authors.initials: F
authors.lastname: Suzuki
authors.forename: T
authors.initials: T
authors.lastname: Nakamura
authors.forename: S
authors.initials: S
authors.lastname: Futagawa
mesh_terms: D000328:Adult; D002908:Chronic Disease; D003251:Constriction, Pathologic; D005355:Fibrosis; D006801:Humans; D006975:Hypertension, Portal / Q000209:etiology* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010179:Pancreas / Q000473:pathology*; D019512:Pancreatitis, Alcoholic / Q000150:complications*; D013162:Splenic Vein / Q000473:pathology*; D013927:Thrombosis / Q000473:pathology