Immunostimulating activity of Celosian, an antihepatotoxic polysaccharide isolated from Celosia argentea.
Celosian, an acidic polysaccharide from the seeds of Celosia argenteo (Amaranthaceae) was found to be a potent antihepatotoxic agent for chemical and immunological liver injury models in animals. The immunomodulating action of celosian was studied to clarify the preventive mechanism of celosian on liver injuries. Celosian induced tumor necrosis factor-alpha (TNF-alpha) production in mice. Celosian also induced the production of interleukin-1 beta (IL-1 beta) and nitric oxide (NO) in macrophage cell line J774.1 in a concentration-dependent manner (1 to 1000 micrograms/ml). Moreover, celosian induced IL-1 beta secretion in human mononuclear cells. In addition, celosian enhanced gamma interferon (IFN-gamma) production activity of concanavalin A (Con A) in mice spleen cells, though celosian alone did not significantly influence IFN-gamma production. These results indicate that celosian is an immunostimulating agent in addition to antihepatotoxic effects.
Hase
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Research Institute for Wakan-Yaku (Traditional Sino-Japanese Medicines), Toyama Medical and Pharmaceutical University, Japan.
Basnet
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Kadota
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Namba
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D000276:Adjuvants, Immunologic / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D002460:Cell Line; D016207:Cytokines / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D007371:Interferon-gamma / Q000096:biosynthesis; D007375:Interleukin-1 / Q000096:biosynthesis; D007564:Japan; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology*; D008264:Macrophages; D008297:Male; D008519:Medicine, Traditional; D051379:Mice; D008807:Mice, Inbred BALB C; D008815:Mice, Inbred Strains; D009000:Monocytes / Q000187:drug effects / Q000276:immunology*; D009569:Nitric Oxide / Q000096:biosynthesis; D010936:Plant Extracts; D011134:Polysaccharides / Q000302:isolation & purification / Q000494:pharmacology*; D012639:Seeds; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis
D000276:Adjuvants, Immunologic; D016207:Cytokines; D007375:Interleukin-1; D010936:Plant Extracts; D011134:Polysaccharides; D014409:Tumor Necrosis Factor-alpha; C105332:celosian; D009569:Nitric Oxide; D007371:Interferon-gamma