Randomized controlled trial of superovulation and insemination for infertility associated with minimal or mild endometriosis.
OBJECTIVE
To evaluate the efficacy of superovulation and IUI versus no treatment for infertility associated with minimal or mild endometriosis.


METHODS
Randomized trial.


METHODS
London Health Sciences Centre, University Campus, The University of Western Ontario, London, Ontario; and Royal Victoria Hospital, McGill University, Montreal, Quebec, Canada.


METHODS
Three hundred eleven cycles in 103 couples in whom minimal or mild endometriosis was the sole identified subfertility factor.


METHODS
Superovulation with FSH and IUI.


METHODS
Live birth.


RESULTS
Live birth followed 14 of 127 (11%) superovulation and IUI cycles and 4 of 184 (2%) no-treatment cycles. The odds ratio was 5.6 (95% confidence interval 1.8 to 17.4) in favor of superovulation and IUI.


CONCLUSIONS
Treatment with superovulation and IUI was associated with superior outcome both by crude live-birth rates and proportional hazard analysis.
Tummon
I S
IS
University of Western Ontario, London, Canada.
Asher
L J
LJ
Martin
J S
JS
Tulandi
T
T
D000328:Adult; D000704:Analysis of Variance; D004715:Endometriosis / Q000150:complications* / Q000601:surgery; D005260:Female; D005640:Follicle Stimulating Hormone / Q000008:administration & dosage; D005500:Follow-Up Studies; D006801:Humans; D007247:Infertility, Female / Q000209:etiology / Q000628:therapy*; D007315:Insemination, Artificial; D008297:Male; D011247:Pregnancy; D011256:Pregnancy Outcome; D016016:Proportional Hazards Models; D011446:Prospective Studies; D013480:Superovulation
D005640:Follicle Stimulating Hormone