title: Ipsilateral testicular hypotrophy is associated with decreased sperm counts in infertile men with varicoceles.
abstract: OBJECTIVE
  The presence of ipsilateral testicular growth retardation (hypotrophy) is the most common indication for prophylactic varicocele repair in adolescents in an effort to prevent future infertility. We examined the relationship between semen parameters and ipsilateral versus contralateral testicular size in men with unilateral varicoceles to determine whether testicular size is an appropriate parameter for predicting future fertility.
  
  
  METHODS
  We studied the records of consecutive patients with palpable unilateral left varicoceles for whom a history, physical examination and semen analysis were available. Total motile sperm counts of men with and without ipsilateral testicular hypotrophy were compared.
  
  
  RESULTS
  We identified 611 patients with unilateral clinical left varicoceles, including 305 (50%) with ipsilateral testicular hypotrophy. Mean total motile sperm counts plus or minus standard error of mean were significantly less in the patients with than without testicular hypotrophy (80 +/- 5.2 versus 126 +/- 7.8 x 10(6) sperm, p = 0.0018). Hypotrophy was more common in patients with large varicoceles (73%) than in those with medium (53%) or small (43%) varicoceles.
  
  
  CONCLUSIONS
  Infertile patients with testicular hypotrophy associated with unilateral varicoceles have worse semen parameters than those without hypotrophy. These data support the practice of varicocele repair in adolescents with varicocele associated testicular growth retardation.
authors.affiliation: Department of Urology, Brown University School of Medicine, Providence, Rhode Island, USA.
authors.forename: M
authors.initials: M
authors.lastname: Sigman
authors.forename: J P
authors.initials: JP
authors.lastname: Jarow
mesh_terms: D000328:Adult; D006801:Humans; D007248:Infertility, Male / Q000150:complications* / Q000517:prevention & control; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D013076:Sperm Count; D013737:Testis / Q000473:pathology*; D014646:Varicocele / Q000150:complications*