title: The global regulator CsrA of Escherichia coli is a specific mRNA-binding protein.
abstract: The csrA gene encodes a global regulatory protein which facilitates glgC mRNA decay in vivo. A purified recombinant CsrA protein was found to inhibit in vitro glg (glycogen biosynthesis) gene expression posttranscriptionally and bind specifically to a glgC runoff transcript without causing its decay. Our results provide further insight into the mechanism by which CsrA functions as an mRNA decay factor.
authors.affiliation: Department of Microbiology and Immunology, University of North Texas Health Science Center at Fort Worth, 76107-2699, USA.
authors.forename: M Y
authors.initials: MY
authors.lastname: Liu
authors.forename: T
authors.initials: T
authors.lastname: Romeo
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D004926:Escherichia coli / Q000235:genetics / Q000378:metabolism*; D029968:Escherichia coli Proteins; D015964:Gene Expression Regulation, Bacterial; D006003:Glycogen / Q000096:biosynthesis; D009876:Operon; D012329:RNA, Bacterial / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism*; D016601:RNA-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D012097:Repressor Proteins; D014158:Transcription, Genetic
chemical_list: D001426:Bacterial Proteins; C093587:CsrA protein, E coli; D029968:Escherichia coli Proteins; D012329:RNA, Bacterial; D012333:RNA, Messenger; D016601:RNA-Binding Proteins; D012097:Repressor Proteins; D006003:Glycogen