Regulation of proteasome structure and function.
Proteasomes are cylindrical particles made up of a stack of four heptameric rings. In animal cells the outer rings are made up of 7 different types of alpha subunits and the inner rings are composed of 7 out of 10 possible different beta subunits. Regulatory complexes can bind to the ends of the cylinder. We have investigated aspects of the assembly, activity and subunit composition of core proteasome particles and 26S proteasomes, the localization of proteasome subpopulations, and the possible role of phosphorylation in determining proteasome localization, activities and association with regulatory components.
Rivett
A J
AJ
Department of Biochemistry, University of Bristol, School of Medical Sciences, UK.
Mason
G G
GG
Murray
R Z
RZ
Reidlinger
J
J
D000818:Animals; D019843:Archaeal Proteins; D010450:Endopeptidases / Q000378:metabolism*; D006801:Humans; D010447:Peptide Hydrolases / Q000378:metabolism*; D046988:Proteasome Endopeptidase Complex
D019843:Archaeal Proteins; D010450:Endopeptidases; D010447:Peptide Hydrolases; D046988:Proteasome Endopeptidase Complex; C061553:ATP dependent 26S protease; C093138:proteasome, Thermoplasma