Anti-PL 4 in patients with systemic lupus erythematosus with severe renal and haematological disease.
Anti-PL 4 is an autoantibody which binds to a 150 kDa polypeptide and is found in approximately 1% of SLE sera. The clinical and laboratory features of 16 patients who have had anti-PL 4 detected in their serum are presented. Anti-PL 4 is highly specific for SLE (100%) and identifies a population of patients who typically develop severe renal (75%) and haematological disease (100%).
Marguerie
C
C
Rheumatology Unit, RPMS, Hammersmith Hospital, London, UK.
Bunn
C C
CC
Black
C M
CM
So
A K
AK
Walport
M J
MJ
D000918:Antibody Specificity; D001323:Autoantibodies / Q000032:analysis*; D015415:Biomarkers / Q000032:analysis; D006682:HLA-DP Antigens / Q000276:immunology; D006402:Hematologic Diseases / Q000175:diagnosis; D006801:Humans; D007674:Kidney Diseases / Q000175:diagnosis / Q000276:immunology; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000276:immunology*; D011233:Precipitin Tests
D001323:Autoantibodies; D015415:Biomarkers; D006682:HLA-DP Antigens