title: A diabetic case with hemoglobin J-Meerut and low HbA1C levels.
abstract: A diabetic patient with hemoglobin (Hb) J-Meerut and low HbA1C levels is reported. An automatic glycohemoglobin analyzer used for the determination of HbA1C revealed an abnormal peak of the peripheral blood obtained from a Japanese female with diabetes. She showed a lower HbA1C level (3.7%) than expected from her fasting plasma glucose (172 mg/dl). High performance liquid chromatography and isoelectric focusing indicated that her abnormal hemoglobin was Hb J-Meerut [alpha 120(H3)Ala-->Glu] and it accounted for 28.3% of the total hemoglobin. Abnormal hemoglobinemia should be considered when a major discrepancy between the levels of HbA1C and fasting plasma glucose is observed.
authors.affiliation: Department of Internal Medicine, Tokai University School of Medicine, Kanagawa.
authors.forename: M
authors.initials: M
authors.lastname: Yagame
authors.forename: K
authors.initials: K
authors.lastname: Jinde
authors.forename: D
authors.initials: D
authors.lastname: Suzuki
authors.forename: N
authors.initials: N
authors.lastname: Saotome
authors.forename: H
authors.initials: H
authors.lastname: Takano
authors.forename: R
authors.initials: R
authors.lastname: Tanabe
authors.forename: H
authors.initials: H
authors.lastname: Sato
authors.forename: K
authors.initials: K
authors.lastname: Kurokawa
authors.forename: H
authors.initials: H
authors.lastname: Sakai
authors.forename: M
authors.initials: M
authors.lastname: Matsumae
authors.forename: H
authors.initials: H
authors.lastname: Mase
authors.forename: T
authors.initials: T
authors.lastname: Harano
mesh_terms: D001786:Blood Glucose / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000235:genetics*; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism*; D006448:Hemoglobin J / Q000235:genetics* / Q000302:isolation & purification / Q000378:metabolism*; D006801:Humans; D007525:Isoelectric Focusing; D008875:Middle Aged
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin; D006448:Hemoglobin J; C060130:hemoglobin J Meerut