Evaluation of the antifungal activity of natural xanthones from Garcinia mangostana and their synthetic derivatives.
The antifungal activity of several xanthones isolated from the fruit hulls of Garcinia mangostana and some derivatives of mangostin against three phytopathogenic fungi, Fusarium oxysporum vasinfectum, Alternaria tenuis, and Dreschlera oryzae, has been evaluated. The natural xanthones showed good inhibitory activity against the three fungi. Substitution in the A and C rings has been shown to modify the bioactivities of the compounds.
Gopalakrishnan
G
G
Centre for Agrochemical Research, SPIC Science Foundations, Madras, India.
Banumathi
B
B
Suresh
G
G
D000478:Alkylation; D000528:Alternaria / Q000187:drug effects; D000935:Antifungal Agents / Q000302:isolation & purification* / Q000494:pharmacology; D005670:Fusarium / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D003904:Mitosporic Fungi / Q000187:drug effects; D010946:Plants, Medicinal / Q000737:chemistry*; D014970:Xanthines / Q000302:isolation & purification* / Q000494:pharmacology
D000935:Antifungal Agents; D014970:Xanthines