title: Induction of c-fos gene expression by spinal cord transection in Sus scrofa.
abstract: Functional responses of primary sensory afferents and spinal cord were monitored in swine subjected to a high cervical (C1) spinal transection. Two and a half hours after transection, dorsal root ganglia and cervical and thoracolumbar spinal segments were processed immunocytochemically for the c-fos gene product, Fos and related antigens. In spinal-transected animals, Fos-like immunoreactivity (FLI) was induced in spinal laminae I, V, VII and X and the intermediolateral cell column but not in sensory ganglia as compared to controls: spinal-intact age-matched littermates. Spinal laminae expressing FLI harbor sympathetic and somatic interneurons and may aid in maintaining sympathetic outflow.
authors.affiliation: Department of Neurology and Neuroscience, Cornell University Medical College, New York, NY 10021, USA.
authors.forename: D A
authors.initials: DA
authors.lastname: Ruggiero
authors.forename: A L
authors.initials: AL
authors.lastname: Sica
authors.forename: M
authors.initials: M
authors.lastname: Anwar
authors.forename: I
authors.initials: I
authors.lastname: Frasier
authors.forename: N
authors.initials: N
authors.lastname: Gootman
authors.forename: P M
authors.initials: PM
authors.lastname: Gootman
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D015870:Gene Expression / Q000235:genetics*; D016760:Proto-Oncogene Proteins c-fos / Q000096:biosynthesis*; D013119:Spinal Cord Injuries / Q000378:metabolism*; D013552:Swine
chemical_list: D016760:Proto-Oncogene Proteins c-fos