Rapid induction of B-cell lymphomas by avian leukosis virus.
Avian leukosis viruses (ALVs) that induce rapid B-cell lymphomas integrate into the c-myb gene and produce an ALV-myb read-through RNA, which is spliced to produce a truncated Myb protein. The genetic determinants of such recombinant ALVs have been mapped to a 42-nt deletion within the gag gene. This deletion increases splicing efficiency since it is located within a negative regulator of splicing. We propose that the deletion leads to increased production of Myb protein by increasing splicing of an ALV-myb pre-mRNA.
Beemon
K L
KL
Department of Biology, Johns Hopkins University, Baltimore, MD 21218, USA.
O'Reilly
M M
MM
Smith
M R
MR
Smith
R E
RE
Dunkel
I
I
Hayward
W S
WS
D000818:Animals; D001354:Avian Leukosis Virus / Q000235:genetics*; D002645:Chickens; D015750:Genes, gag; D016393:Lymphoma, B-Cell / Q000503:physiopathology / Q000821:virology*; D011518:Proto-Oncogene Proteins / Q000096:biosynthesis / Q000235:genetics; D020598:Proto-Oncogene Proteins c-myb; D011519:Proto-Oncogenes; D012322:RNA Precursors / Q000378:metabolism; D012326:RNA Splicing; D012333:RNA, Messenger / Q000096:biosynthesis; D012367:RNA, Viral / Q000096:biosynthesis; D011995:Recombination, Genetic; D017384:Sequence Deletion; D015534:Trans-Activators / Q000096:biosynthesis / Q000235:genetics
D011518:Proto-Oncogene Proteins; D020598:Proto-Oncogene Proteins c-myb; D012322:RNA Precursors; D012333:RNA, Messenger; D012367:RNA, Viral; D015534:Trans-Activators