title: Prevalence of human papilloma virus 16 or 18 in cervical cancer in Hualien, eastern Taiwan.
abstract: In order to determine the association of human papilloma virus (HPV) with cervical cancer of patients in the Hualien area, we analyzed 40 cervical cancer specimens using polymerase chain reaction (PCR) to detect the presence of HPV type 16 (HPV-16) and type 18 (HPV-18) genomes. The results showed that at least 70% (28/40) of the specimens had HPV DNA. Of the 37 squamous cell carcinomas of the cervix, HPV-16 was present in 25 cases (68%) and HPV-18 in 2 (5.4%). HPV-16 DNA was detected in one of 2 adenocarcinomas and HPV-18 in a case of small cell carcinoma. Seven (87.5%) of 8 specimens from aborigines were HPV-positive. These findings support a role for HPV in the development of cervical cancer in the Hualien population.
authors.affiliation: Department of Pathology, Tzu-Chi General Hospital, Hualien, Taiwan, Republic of China.
authors.forename: Y H
authors.initials: YH
authors.lastname: Hsu
authors.forename: T C
authors.initials: TC
authors.lastname: Wei
authors.forename: I J
authors.initials: IJ
authors.lastname: Horng
authors.forename: W C
authors.initials: WC
authors.lastname: Jan
authors.forename: I J
authors.initials: IJ
authors.lastname: Su
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D027383:Papillomaviridae / Q000502:physiology*; D016133:Polymerase Chain Reaction; D015995:Prevalence; D013624:Taiwan; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology* / Q000821:virology*