title: Crystallization and preliminary crystallographic analysis of the N-terminal actin binding domain of human fimbrin.
abstract: We have crystallized the N-terminal actin binding domain (ABD1) of human fimbrin, a representative member of the largest class of actin crosslinking proteins. Diffraction from these crystals is consistent with the orthorhombic space group P2(1)2(1)2(1) (a = 50.03 A, b = 61.24 A, c = 102.30 A). These crystals contain one molecule in the asymmetric unit and diffract to at least 1.9 A resolution. The crystal structure of ABD1 will be the first structure of an actin crosslinking domain.
authors.affiliation: Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
authors.forename: S C
authors.initials: SC
authors.lastname: Goldsmith
authors.forename: N
authors.initials: N
authors.lastname: Pokala
authors.forename: P
authors.initials: P
authors.lastname: Matsudaira
authors.forename: S C
authors.initials: SC
authors.lastname: Almo
mesh_terms: D002352:Carrier Proteins / Q000737:chemistry*; D003460:Crystallization; D018360:Crystallography, X-Ray; D006801:Humans; D008562:Membrane Glycoproteins / Q000737:chemistry*; D008840:Microfilament Proteins / Q000737:chemistry*; D017434:Protein Structure, Tertiary
chemical_list: D002352:Carrier Proteins; D008562:Membrane Glycoproteins; D008840:Microfilament Proteins; C026742:plastin