Pharmacokinetics of sertindole and dehydrosertindole in volunteers with normal or impaired renal function.
OBJECTIVE
To study the effect of renal impairment on the pharmacokinetics of sertindole.


METHODS
A single 4 mg oral dose of sertindole was given to normal subjects (n = 6) and subjects with various degrees of impaired renal function (n = 18) classified into mild, moderate, and severe/hemodialysis based on their creatinine clearance). The relationships between the pharmacokinetic parameters and the degree of renal impairment were investigated using regression analysis with creatinine clearance as an explanatory variable along with body weight. Subjects were also genotyped for CYP2D6-A or 2D6-B mutations.


RESULTS
The mean CL/f and t1/2 values of sertindole ranged from 14 to 31 1.h-1 and from 73 to 93 h, respectively, and were not significantly related to creatinine clearances. There was no indication of any influence of creatinine clearance on the fraction of sertindole (0.994-0.995) binding to plasma proteins. The total fraction of the sertindole dose removed by dialysis was less than 0.1% Subjects with B/B genotype (n = 2) for CYP2D6 were associated with a distinctly lower clearance of sertindole (6.3 vs 25.3 1.h-1) than subjects with wt/wt genotype for CYP2D6.


CONCLUSIONS
Since the pharmacokinetics of sertindole are unchanged by renal impairment, dosage adjustment does not appear to be necessary for subjects with various degrees of renal insufficiency or subjects with renal failure requiring hemodialysis.
Wong
S L
SL
Department of Pharmacokinetics and Biopharmaceutics, Abbott Laboratories, Abbott Park, IL 60064-3500, USA. shekman.wong@abbott.com
Menacherry
S
S
Mulford
D
D
Schmitz
P J
PJ
Locke
C
C
Granneman
G R
GR
D000328:Adult; D014150:Antipsychotic Agents / Q000493:pharmacokinetics*; D003404:Creatinine / Q000378:metabolism; D019389:Cytochrome P-450 CYP2D6 / Q000378:metabolism; D006801:Humans; D007093:Imidazoles / Q000493:pharmacokinetics*; D007211:Indoles / Q000493:pharmacokinetics*; D007668:Kidney / Q000378:metabolism*; D007674:Kidney Diseases / Q000378:metabolism*; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D006435:Renal Dialysis; D012559:Schizophrenia / Q000378:metabolism
D014150:Antipsychotic Agents; D007093:Imidazoles; D007211:Indoles; D003404:Creatinine; D019389:Cytochrome P-450 CYP2D6; C066304:sertindole