title: Cytotoxic and antiplatelet aggregation principles from Aglaia elliptifolia.
abstract: Two related 1H-2,3,3a,8b-tetrahydrocyclopenta[b]benzofurans, aglafolin (1a) and rocaglamide (2), isolated from the stems of Aglaia elliptifolia, showed significant cytotoxicity in six cancer cell lines. Aglafolin (1a) was also found to completely block platelet aggregation caused by arachidonic acid and platelet-activating factor at 100 microM and 2 ng/mL, respectively.
authors.affiliation: Department of Chemistry, National Cheng-Kung University, Tainan, Taiwan, Republic of China.
authors.forename: T S
authors.initials: TS
authors.lastname: Wu
authors.forename: M J
authors.initials: MJ
authors.lastname: Liou
authors.forename: C S
authors.initials: CS
authors.lastname: Kuoh
authors.forename: C M
authors.initials: CM
authors.lastname: Teng
authors.forename: T
authors.initials: T
authors.lastname: Nagao
authors.forename: K H
authors.initials: KH
authors.lastname: Lee
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology; D001572:Benzofurans / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D051379:Mice; D010936:Plant Extracts / Q000737:chemistry; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology; D011817:Rabbits; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D014407:Tumor Cells, Cultured
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D001572:Benzofurans; D010936:Plant Extracts; D010975:Platelet Aggregation Inhibitors; C077355:aglafoline; C107772:rocaglamide