Lymphocyte-specific genomic instability and risk of lymphoid malignancy.
Genetic instability is a force that links evolution, development and cancer. We have developed a quantifiable assay for a particular kind of lymphocyte-specific genetic instability (antigen receptor trans-rearrangements) mediated by the V(D)J recombinase complex. We find that the level of this type of instability correlates (at the population level) with risk for lymphoid malignancy. We have developed a murine model for this measure of instability to allow a more refined analysis of the genetic and environmental factors that sum to define population cancer risk.
Kirsch
I R
IR
National Cancer Institute-Navy Medical Oncology Branch, Bethesda, MD 20889-5105, USA.
Lista
F
F
D000818:Animals; D001260:Ataxia Telangiectasia / Q000150:complications / Q000235:genetics; D001483:Base Sequence; D004247:DNA / Q000235:genetics; D004254:DNA Nucleotidyltransferases / Q000378:metabolism; D004195:Disease Models, Animal; D015321:Gene Rearrangement; D006801:Humans; D008214:Lymphocytes / Q000276:immunology*; D008223:Lymphoma / Q000209:etiology* / Q000235:genetics / Q000276:immunology; D051379:Mice; D011946:Receptors, Antigen / Q000235:genetics; D011995:Recombination, Genetic; D012307:Risk Factors; D045567:VDJ Recombinases
D011946:Receptors, Antigen; D004247:DNA; D004254:DNA Nucleotidyltransferases; D045567:VDJ Recombinases