The role of NMDA receptors in central action of angiotensin II.
The influence of noncompetitive (MK-801), competitive (AP-7) and the antagonist of polyamines site of NMDA receptor (arcaine) on the central activity of angiotensin II (A II) was studied. The open field test, conditioning of active avoidance responses (CARs) and passive avoidance situation was used to investigate learning and memory in rats. All used antagonists decreased beneficial action of A II on these processes.
Wiśniewski
K
K
Department of Pharmacology, Medical Academy of Białystok, Poland.
Lutostanska
A
A
Artemowicz
B
B
D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D001645:Biguanides / Q000494:pharmacology; D001921:Brain / Q000187:drug effects*; D003213:Conditioning, Psychological / Q000187:drug effects; D016291:Dizocilpine Maleate / Q000494:pharmacology; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology; D008297:Male; D008568:Memory / Q000187:drug effects; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D016194:Receptors, N-Methyl-D-Aspartate / Q000502:physiology*
D001645:Biguanides; D018691:Excitatory Amino Acid Antagonists; D016194:Receptors, N-Methyl-D-Aspartate; D000804:Angiotensin II; C006624:arcaine; D016291:Dizocilpine Maleate