[Placental transfer of vecuronium administered with priming principle regimen in patients undergoing cesarean section].
Eight women having cesarean section under general anesthesia received vecuronium (VCB) 0.01 mg.kg-1 as a priming dose, followed 180 s later by 0.11 mg.kg-1 as an intubation dose. Subsequently, VCB concentrations of umbilical venous and maternal arterial blood at delivery were assayed. The time from the injection of intubation dose to delivery was 283 +/- 55 (mean +/- SD) s. Umbilical and maternal VCB concentrations at delivery were 79.4 +/-36.1 1ng.ml-1 (UV) and 1258.3 +/- 464.1 ng.ml-1 (MA). respectively. Thus, the umbilical venous to maternal arterial VCB concentration ratio (UV.MA-1) was 0.07 +/- 0.02. One-min and 5-min Apgar scores were 8-9 and 9-10, respectively. Judging from previous reports concerning VCB administration during cesarean section, total of VCB 0.12 mg.kg-1 may be an overdose. We concluded therefore that of total VCB 0.10 mg.kg-1 seems to be an appropriate dose for cesarean section.
Kaneko
T
T
Department of Anesthesiology, Central Aizu General Hospital, Aizuwakamatsu.
Iwama
H
H
Tobishima
S
S
Watanabe
K
K
Komatsu
T
T
Takeichi
K
K
Tase
C
C
D000328:Adult; D000768:Anesthesia, General; D000773:Anesthesia, Obstetrical; D002585:Cesarean Section; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008431:Maternal-Fetal Exchange; D003473:Neuromuscular Nondepolarizing Agents / Q000493:pharmacokinetics*; D010920:Placenta / Q000378:metabolism*; D011229:Preanesthetic Medication / Q000379:methods; D011247:Pregnancy; D014673:Vecuronium Bromide / Q000493:pharmacokinetics*
D003473:Neuromuscular Nondepolarizing Agents; D014673:Vecuronium Bromide