Neurofibrillary pathology in the human paraventricular and supraoptic nuclei.
Severe neurofibrillary changes were identified in the paraventricular and supraoptic nuclei of elderly individuals using markers for Alzheimer's disease-related intraneuronal pathology. This neurofibrillary pathology is remarkable in that the magnocellular paraventricular and supraoptic nuclei are particularly resistant to Alzheimer's disease. Moreover, the changes were observed even in non-demented controls, indicating that they develop independently of Alzheimer's disease. The alterations in the paraventricular and supraoptic nuclei were consistently accompanied by neurofibrillary changes in the mediobasal hypothalamus.
Schultz
C
C
Department of Morphology, Johann Wolfgang Goethe University, Frankfurt/Main, Germany. Schultz@em.uni-frankfurt.de
Ghebremedhin
E
E
Braak
H
H
Braak
E
E
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000473:pathology; D005260:Female; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000473:pathology; D008297:Male; D008875:Middle Aged; D016874:Neurofibrillary Tangles / Q000473:pathology*; D009454:Neurofibrils / Q000473:pathology*; D010286:Paraventricular Hypothalamic Nucleus / Q000473:pathology*; D012737:Sex Factors; D013495:Supraoptic Nucleus / Q000473:pathology*