[Effect of IL-4 on biological regulation of tumor cell lines].
The effect of IL-4 on biological regulation of tumor cell lines was observed by using human recombinant interleukin-4. The observation included cell proliferation, differentiation, cell surface marker and cytokine secretion. The effect of IL-4 on cell proliferation of nine cell lines was different. It showed 4/9 inhibitory effect, 3/9 enhancing effect and 2/9 no effect. The inhibitory effect of IL-4 on U937 cell proliferation was correlated with cell differentiation. IL-4 enhanced the expression of cell surface markers (including MHC class I, MHC class II and TAA) of some cell lines. Furthermore, IL-4 inhibited the production of IL-2 by MLA144. The preliminary results indicate that the effect of IL-4 on biological regulation of tumor cell lines is benefitial for controlling tumor cell growth and enhancing tumor cell recognition by effector cells. However, the down regulation also could be exerted.
Zhong
M
M
Cancer Institute, CAMS and PUMC, Beijing.
Wu
Y
Y
Yu
L
L
Wang
D
D
Zhang
Y
Y
D000818:Animals; D015295:Antigens, Tumor-Associated, Carbohydrate / Q000378:metabolism; D014408:Biomarkers, Tumor / Q000378:metabolism*; D002455:Cell Division / Q000187:drug effects; D015395:Histocompatibility Antigens Class I / Q000378:metabolism; D000949:Histocompatibility Antigens Class II / Q000378:metabolism; D006801:Humans; D007376:Interleukin-2 / Q000378:metabolism; D015847:Interleukin-4 / Q000494:pharmacology*; D011993:Recombinant Fusion Proteins / Q000494:pharmacology*; D014407:Tumor Cells, Cultured / Q000187:drug effects*
D015295:Antigens, Tumor-Associated, Carbohydrate; D014408:Biomarkers, Tumor; D015395:Histocompatibility Antigens Class I; D000949:Histocompatibility Antigens Class II; D007376:Interleukin-2; D011993:Recombinant Fusion Proteins; D015847:Interleukin-4