Suramin enhances ethanol-induced injury to gastric mucosa in rats.
Suramin is currently used in clinical practice as antineoplastic agent because of its complex interaction with the biological activity of various growth factors involved in tumor progression. The influence exerted by suramin on gastric injury induced in rats by intraluminal injection of absolute ethanol was investigated in the present study. The morphometric analysis of gastric histological sections revealed that suramin, 18 mg/kg, administered intraperitoneally for 14 days every other day, caused a marked enhancement of ethanol-induced mucosal damage. This effect was more pronounced 1-8 hr following ethanol administration, and it was still significant after 48 hr. In suramin-treated animals the evaluation of Alcian blue recovery from gastric-bound mucus showed that the levels of adherent mucus were significantly lower than those detected in untreated rats. In addition, pretreatment with suramin did not modify basal acid secretion, but caused potentiation of acid output stimulated by pylorus ligation or electrical vagal stimulation. Overall, the present results indicate that suramin exerts a negative influence on both gastric protective and repairing mechanisms. Due to the peculiar pharmacodynamic profile of suramin, it is suggested that interference with endogenous growth factors, endowed with physiological protective activity on gastric mucosa, might account for the damage-enhancing action of this drug.
Blandizzi
C
C
Institute of Pharmacology, School of Medicine and Dentistry, University of Pisa, Italy.
Gherardi
G
G
Marveggio
C
C
Lazzeri
G
G
Natale
G
G
Carignani
D
D
Colucci
R
R
Del Tacca
M
M
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000633:toxicity; D004357:Drug Synergism; D000431:Ethanol / Q000633:toxicity*; D005744:Gastric Acid / Q000378:metabolism; D005753:Gastric Mucosa / Q000187:drug effects* / Q000473:pathology; D008297:Male; D009093:Mucus / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D013498:Suramin / Q000494:pharmacology* / Q000633:toxicity
D000970:Antineoplastic Agents; D000431:Ethanol; D013498:Suramin