[A study on cAMP and Ca-CaM of the epithelium in human normal and cataractous lenses].
OBJECTIVE
The study was designed to study the relationship between calcium-calmodulin (Ca-CaM) and cyclic adenosine monophosphate (cAMP) systems and their possible cataractogenic effects.


METHODS
We measured cAMP, Ca and Ca-CaM in the epithelium of human normal and cataractous lenses by enzymic and radioimmunoassay methods.


RESULTS
The levels of Ca-CaM in the epithelium of senile cataractous lens were higher, while of cAMP were lower than that in the normal lens.


CONCLUSIONS
The results imply that the low level of cAMP might cause the high level of calcium in the lens which is possibly a cataractogenic factor. The dangerous role of calcium is amplified by the elevation of Ca-CaM.
Liu
X
X
Department of Ophthalmology, General Naval Hospital, Beijing.
Fang
Q
Q
Yan
M
M
D000293:Adolescent; D000328:Adult; D000368:Aged; D002118:Calcium / Q000378:metabolism*; D002147:Calmodulin / Q000378:metabolism*; D002386:Cataract / Q000378:metabolism*; D000242:Cyclic AMP / Q000378:metabolism*; D004848:Epithelium / Q000378:metabolism; D006801:Humans; D007908:Lens, Crystalline / Q000378:metabolism*; D008875:Middle Aged; D011863:Radioimmunoassay
D002147:Calmodulin; D000242:Cyclic AMP; D002118:Calcium