title: Common variable immunodeficiency associated with myelocathexis and altered membrane sodium-proton antiport.
abstract: Alterations in protein kinase C (PKC) activity have been implied in the pathogenesis of common variable immunodeficiency (CVID). We analyzed amiloride-sensitive red blood cell Na+/H+ exchange (sodium-proton antiport, SPA) and its response to protein kinase stimulation in a patient with CVID. Compared with healthy subjects or patients with sepsis, a unique pattern of SPA activation has been shown. The patient's SPA was decreased and unresponsive to PKC stimulation, whereas stimulation by insulin, a tyrosine kinase activator, restored SPA activity. An alteration of serine-threonine phosphorylation is suggested as a possible mechanism for the immune failure.
authors.affiliation: Department of Medicine C, Chaim Sheba Medical Center Tel Hashomer, Sackler, Faculty of Medicine, Tel Aviv University, Israel.
authors.forename: H
authors.initials: H
authors.lastname: Gur
authors.forename: R
authors.initials: R
authors.lastname: Koldanov
authors.forename: A
authors.initials: A
authors.lastname: Segal
authors.forename: G
authors.initials: G
authors.lastname: Schiby
authors.forename: O
authors.initials: O
authors.lastname: Spielberg
authors.forename: W
authors.initials: W
authors.lastname: Koren
mesh_terms: D000328:Adult; D000917:Antibody Formation; D001853:Bone Marrow / Q000473:pathology; D017074:Common Variable Immunodeficiency / Q000378:metabolism* / Q000473:pathology; D004912:Erythrocytes / Q000378:metabolism; D005260:Female; D006801:Humans; D010766:Phosphorylation; D011493:Protein Kinase C / Q000378:metabolism; D017923:Sodium-Hydrogen Exchangers / Q000097:blood*
chemical_list: D017923:Sodium-Hydrogen Exchangers; D011493:Protein Kinase C