Controlled release of cisplatin incorporated into biodegradable poly-d, l-lactic acid.
Using a melt-pressing technique, we produced a small solid cylinder containing cisplatin (CDDP) embedded in poly-d, l-lactic acid (CDDP-PLA). The in vitro release of CDDP from the polymer was examined in an immersion system. CDDP was released continuously for more than four weeks with no initial burst. Drug distribution for CDDP-PLA was compared with CDDP solution (CDDP-SOL) by subcutaneous administration into the back of rats. In the CDDP-PLA group, a high concentration of CDDP was maintained in the subcutaneous tissues near the implants for 20 days. However, in the CDDP-SOL group, the concentration of CDDP was low by 10 days after drug administration. CDDP-PLA may become a useful tool in locoregional chemotherapy as a solid type of drug delivery system with longlasting release.
Natsugoe
S
S
First Department of Surgery, Kagoshima University School of Medicine, Japan.
Kumanohoso
T
T
Tokuda
K
K
Shimada
M
M
Mueller
J
J
Nakamura
K
K
Yamada
K
K
Fukuzaki
H
H
Aikou
T
T
D000818:Animals; D001672:Biocompatible Materials; D002945:Cisplatin / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D016503:Drug Delivery Systems; D007279:Injections, Subcutaneous; D019344:Lactic Acid; D008297:Male; D011091:Polyesters; D011108:Polymers; D051381:Rats; D013997:Time Factors; D014018:Tissue Distribution
D001672:Biocompatible Materials; D011091:Polyesters; D011108:Polymers; D019344:Lactic Acid; C033616:poly(lactide); D002945:Cisplatin