Association of Campylobacter jejuni serotype with antiganglioside antibody in Guillain-Barré syndrome and Fisher's syndrome.
Using Penner's method and Lior's scheme, we serotyped 31 isolates from patients with Guillain-Barré syndrome, 7 isolates from those with Fisher's syndrome, and isolates from patients with sporadic enteritis. PEN 19 of Campylobacter jejuni was isolated more frequently from the Guillain-Barré syndrome patients (16/31 isolates, 52%) than from the sporadic enteritis patients (5%). LIO 7 of C. jejuni also was isolated more frequently from the Gillain-Barré syndrome patients (14/31 isolates, 45%) than from the enteritis patients (3%). One reason why Guillain-Barré syndrome is rare, despite the high incidence of C. jejuni enteritis, may be the low frequencies of PEN 19 and LIO 7. The frequency of positive anti-GM1 antibody titers in the Guillain-Barré syndrome patients with PEN 19 isolates was higher than that in the Guillain-Barré syndrome and Fisher's syndrome patients without PEN 19 isolates. We speculate that the serotypic determinant of PEN 19 aids in the production of anti-GM1 antibody by a GM1-like lipopolysaccharide. In contrast, 5 of the 7 isolates from the Fisher's syndrome patients belonged to PEN 2:LIO 4. The IgG anti-GQ1b antibody was associated with PEN 2 and LIO 4. These serotypic determinants may aid in the production of IgG anti-GQ1b antibody by a GQ1b-like lipopolysaccharide.
Yuki
N
N
Department of Biochemistry, Faculty of Medicine, Tokyo Medical and Dental University, Japan.
Takahashi
M
M
Tagawa
Y
Y
Kashiwase
K
K
Tadokoro
K
K
Saito
K
K
D000906:Antibodies / Q000032:analysis*; D001259:Ataxia / Q000150:complications; D016123:Campylobacter jejuni / Q000145:classification*; D005732:Gangliosides / Q000276:immunology*; D006680:HLA Antigens / Q000145:classification; D006801:Humans; D009886:Ophthalmoplegia / Q000150:complications; D011115:Polyneuropathies / Q000150:complications / Q000382:microbiology* / Q000503:physiopathology; D011129:Polyradiculoneuropathy / Q000382:microbiology*; D012021:Reflex, Abnormal; D012703:Serotyping; D013577:Syndrome
D000906:Antibodies; D005732:Gangliosides; D006680:HLA Antigens