title: A clerodane diterpene with antibacterial activity from Ajuga lupulina.
abstract: The structure of a new diterpene, C30H46O11, with antibacterial activity against Pseudomonas aeruginose and Escherichia coli, isolated from the fresh whole plants of Ajuga lupulina (Labiatae) was established to be 2 beta-hydroxy-2-methylbutanoyl-3 alpha-lupulin (3-deoxy-14,15-dihydro-2-hydroxy-15-methoxycaryoptinol 2-methylbutanoate), by means of X-ray crystallographic analysis. The present study confirms that the two six-membered rings are in ideal chair conformations.
authors.affiliation: Department of Biological Science and Technology, Nanjing University, People's Republic of China.
authors.forename: H
authors.initials: H
authors.lastname: Chen
authors.forename: R X
authors.initials: RX
authors.lastname: Tan
authors.forename: Z L
authors.initials: ZL
authors.lastname: Liu
authors.forename: C Y
authors.initials: CY
authors.lastname: Zhao
authors.forename: J
authors.initials: J
authors.lastname: Sun
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D004224:Diterpenes / Q000737:chemistry* / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects; D006860:Hydrogen Bonding; D008958:Models, Molecular; D015394:Molecular Structure; D010944:Plants / Q000737:chemistry*; D011550:Pseudomonas aeruginosa / Q000187:drug effects
chemical_list: C106966:2-hydroxy-2-methylbutanoyl-3-lupulin; D000900:Anti-Bacterial Agents; D004224:Diterpenes