Regulation of gene expression in the nervous system by reactive oxygen and nitrogen species.
Reactive oxygen and nitrogen species function as direct and indirect modulators of gene expression through their interactions with transcription factors and also key enzymes in receptor-activated signalling pathways. This regulatory role may become displaced under certain circumstances such as aging, autoimmune responses and viral infection, leading to the pathological outcome associated with inflammatory and degenerative diseases in the CNS.
Merrill
J E
JE
Department of Immunology, Berlex Biosciences, Richmond, CA 94804, USA.
Murphy
S P
SP
D000818:Animals; D005609:Free Radicals / Q000378:metabolism; D005786:Gene Expression Regulation / Q000502:physiology*; D006801:Humans; D009420:Nervous System / Q000378:metabolism*; D009422:Nervous System Diseases / Q000378:metabolism; D009584:Nitrogen / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000378:metabolism*; D014157:Transcription Factors
D005609:Free Radicals; D017382:Reactive Oxygen Species; D014157:Transcription Factors; D009584:Nitrogen