[The contractile reactions of vascular smooth muscles in hypercholesterolemia and changes in the functional activity of the endothelium].
Experiments on the isolated stripes of the portal vein of rabbits in experimental hypercholesterolemia and/or inhibition of endothelium's synthetic function with NO-synthase inhibitor L-NAME revealed the decrease of the contractile responses of vascular smooth muscles to stretching, as well as endothelium-dependent relaxation of aortal stripes to acetylcholine. L-arginine stimulated the synthetic activity of endothelium, thus enabling to use it for the correction of functional disturbances of the endothelium and of the studies responses.
Tkachenko
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D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D001011:Aorta / Q000187:drug effects / Q000503:physiopathology; D001120:Arginine / Q000494:pharmacology; D004036:Diet, Atherogenic; D004730:Endothelium, Vascular / Q000187:drug effects / Q000503:physiopathology*; D004791:Enzyme Inhibitors / Q000494:pharmacology; D006937:Hypercholesterolemia / Q000503:physiopathology*; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects / Q000502:physiology*; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000503:physiopathology*; D019331:NG-Nitroarginine Methyl Ester / Q000494:pharmacology; D011169:Portal Vein / Q000187:drug effects / Q000503:physiopathology; D011817:Rabbits
D004791:Enzyme Inhibitors; D001120:Arginine; D000109:Acetylcholine; D019331:NG-Nitroarginine Methyl Ester