Purification of p-nitrobenzyl C-functionalized diethylenetriamine pentaacetic acids for clinical applications using anion-exchange chromatography.
A general process for the purification of large quantities (5-10 g) of p-nitrobenzyl C-functionalized diethylenetriamine pentaacetic acids is reported. The method of choice to achieve purification for clinical applications is anion-exchange chromatography.
Brechbiel
M W
MW
Radioimmune and Inorganic Chemistry Section, NCI, NIH, Bethesda, MD 20892-1002, USA.
Beitzel
P M
PM
Gansow
O A
OA
D002851:Chromatography, High Pressure Liquid / Q000295:instrumentation / Q000379:methods; D002852:Chromatography, Ion Exchange / Q000295:instrumentation / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy; D004369:Pentetic Acid / Q000737:chemistry / Q000302:isolation & purification*
D004369:Pentetic Acid