[The immunosuppressive activity of filtrates of the culture broth from nonvirulent salmonellae].
Cultural filtrates (CF) of avirulent Salmonella virchow and Salmonella dublin have been studied for their influence on the delayed type hypersensitivity (DTH) to test-antigen in mice. It is found that i.p. injection of CF inhibits DTH in mice. The immunosuppressive activity is indicated in lipid fraction of CF and it may be removed from CF by the O-specific immunosorbent. It is heat-stable and disappears after phenol or trichloroacetic acid treatment. Gel filtration data evidence for high molecular weight of the active factor. These facts indicate to the connection of immunosuppressive activity with native lipopolysaccharide of avirulent Salmonella.
Molozhavaia
O S
OS
Borisova
E V
EV
Borisov
V A
VA
D000818:Animals; D002850:Chromatography, Gel; D003470:Culture Media / Q000302:isolation & purification / Q000494:pharmacology*; D005374:Filtration; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007166:Immunosuppressive Agents / Q000302:isolation & purification / Q000494:pharmacology*; D008070:Lipopolysaccharides / Q000302:isolation & purification / Q000494:pharmacology*; D051379:Mice; D008970:Molecular Weight; D019081:O Antigens / Q000302:isolation & purification / Q000494:pharmacology; D012475:Salmonella / Q000276:immunology / Q000472:pathogenicity*; D014774:Virulence
D003470:Culture Media; D007166:Immunosuppressive Agents; D008070:Lipopolysaccharides; D019081:O Antigens