title: Deoxycytidine kinase mRNA expression in childhood acute lymphoblastic leukemia.
abstract: Initial and relapsed childhood acute lymphoblastic leukemias (ALL) were investigated for mutations and expression of deoxycytidine kinase (dCK). dCK mediating toxicity of 1-beta-D-arabinofuranosylcytosine was analyzed semiquantitatively by RT-PCR and by single-strand conformation polymorphism. We found that patients with initial ALL experienced more frequently a relapse if dCK expression was low or absent. No mutations were found in initial and relapsed ALL.
authors.affiliation: German Cancer Research Centre, Department 0510, Heidelberg.
authors.forename: G
authors.initials: G
authors.lastname: Stammler
authors.forename: F
authors.initials: F
authors.lastname: Zintl
authors.forename: A
authors.initials: A
authors.lastname: Sauerbrey
authors.forename: M
authors.initials: M
authors.lastname: Volm
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001215:Asparaginase / Q000627:therapeutic use; D002478:Cells, Cultured; D002648:Child; D003630:Daunorubicin / Q000627:therapeutic use; D003842:Deoxycytidine Kinase / Q000096:biosynthesis*; D006801:Humans; D009154:Mutation; D016133:Polymerase Chain Reaction; D018807:Polymorphism, Single-Stranded Conformational; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy / Q000201:enzymology*; D011241:Prednisone / Q000627:therapeutic use; D012333:RNA, Messenger / Q000032:analysis / Q000096:biosynthesis*; D014750:Vincristine / Q000627:therapeutic use
chemical_list: D012333:RNA, Messenger; D014750:Vincristine; D003842:Deoxycytidine Kinase; D001215:Asparaginase; D011241:Prednisone; D003630:Daunorubicin