[The effect of the chronic internal administration of the new Russian n-3 polyunsaturated fatty acid concentrate--epaden--on blood coagulation system indices in rabbits].
Daily oral 6-week administration of epaden in a dose containing 0.3 g eucosopentanoic acid and 0.05 g docosahexaenoic acid caused decrease in collagen-induced platelet aggregation in rabbits in vivo and in the activity of the tissue type plasminogen activator, as well as reduction in the level of antithrombin III cofactor activity. No changes were encountered in ADP-induced aggregation, in the platelet count, in platelet adhesion to collagen, and in activated partial thromboplastin time.
Petrukhina
G N
GN
Makarov
V A
VA
Kalugin
S A
SA
Gandel'
V G
VG
D000284:Administration, Oral; D000818:Animals; D000990:Antithrombin III / Q000187:drug effects; D001777:Blood Coagulation / Q000187:drug effects*; D004281:Docosahexaenoic Acids / Q000494:pharmacology*; D004338:Drug Combinations; D015118:Eicosapentaenoic Acid / Q000494:pharmacology*; D010314:Partial Thromboplastin Time; D010973:Platelet Adhesiveness / Q000187:drug effects; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D010976:Platelet Count / Q000187:drug effects; D011817:Rabbits; D013997:Time Factors; D010959:Tissue Plasminogen Activator / Q000187:drug effects
D004338:Drug Combinations; C045153:Maxepa; D010975:Platelet Aggregation Inhibitors; D004281:Docosahexaenoic Acids; D000990:Antithrombin III; D015118:Eicosapentaenoic Acid; D010959:Tissue Plasminogen Activator