[Effects of pre-operative administration of steroids on the serum interleukin (IL)-6, IL-8 and organ injuries in replacement of thoracic aorta].
To investigate whether pre-operative steroids administration decreases the post-operative serum IL-6, IL-8 and prevents organ injuries, we prospectively studied patients undergoing elective replacement of thoracic aorta using an extracorporeal circulation. Six of 10 patients (group S) were pretreated with methylprednisolone 500 mg 2 hours before operation while the other 4 patients (group C) were not. Though post-operative serum IL-6, IL-8, C-reactive protein and amylase elevated in group C, the elevations were significantly decreased in group S (p < 0.05). These findings show that in replacement of thoracic aorta, pre-operative steroid administration decreases the post-operative elevations of serum inflammatory cytokines (IL-6 and IL-8) and may prevent organ injuries.
Nitta
Y
Y
Department of Thoracic and Cardiovascular Surgery, Tohoku University School of Medicine, Sendai, Japan.
Shoji
Y
Y
Shineha
R
R
Oda
K
K
Ito
T
T
Tabayashi
K
K
D000368:Aged; D000681:Amylases / Q000097:blood; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D001013:Aorta, Thoracic / Q000601:surgery*; D005112:Extracorporeal Circulation; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D016209:Interleukin-8 / Q000097:blood*; D008775:Methylprednisolone / Q000008:administration & dosage*; D008875:Middle Aged; D011183:Postoperative Complications / Q000517:prevention & control; D011292:Premedication; D011446:Prospective Studies
D000893:Anti-Inflammatory Agents; D015850:Interleukin-6; D016209:Interleukin-8; D000681:Amylases; D008775:Methylprednisolone