Cellular immune recognition and the biological role of major transplantation antigens.
The experiments leading to the discovery of MHC-restricted T-cell killing of virus-infected cells are described. The implications of MHC- and HLA-restricted T-cell killing for the development of new vaccines and for the understanding of autoimmune disease are discussed.
Zinkernagel
R M
RM
Institute of Experimental Immunology, University of Zurich, Switzerland.
D000818:Animals; D000917:Antibody Formation; D006801:Humans; D007111:Immunity, Cellular / Q000276:immunology*; D008285:Major Histocompatibility Complex / Q000235:genetics / Q000276:immunology* / Q000502:physiology*