title: The effect of iron supplementation on GSH levels, GSH-Px, and SOD activities of erythrocytes in L-thyroxine administration.
abstract: Our aim was to study the effect of iron supplementation on the following aspects of erythrocyte metabolism in experimental hyperthyroidism: glutathione (GSH) levels, glutathione peroxidase (GSH-Px), and superoxide dismutase (SOD) activities. Hyperthyroidism induced by L-thyroxine administrations significantly raised erythrocyte GSH, GSH-Px and SOD levels of the rats (P < 0.001). Likewise, we observed that iron supplementation induced significant rises in erythrocyte GSH, GSH-Px and SOD levels (P < 0.001) as compared with the control group. The erythrocyte GSH, GSH-Px and SOD levels of hyperthyroidism-induced iron-supplemented animals were significantly higher when compared with either the iron-supplemented group (P < 0.001) or the only L-thyroxine-administered hyperthyroid group (P < 0.001, P < 0.05, P < 0.01, respectively). The results of this study show that L-thyroxine administration and/or iron supplementation increases GSH, GSH-Px and SOD levels of erythrocytes.
authors.affiliation: Department of Physiology, Cerrahpasa Medical Faculty, Istanbul University, Turkey.
authors.forename: O
authors.initials: O
authors.lastname: Seymen
authors.forename: A
authors.initials: A
authors.lastname: Seven
authors.forename: G
authors.initials: G
authors.lastname: Candan
authors.forename: G
authors.initials: G
authors.lastname: Yigit
authors.forename: S
authors.initials: S
authors.lastname: Hatemi
authors.forename: H
authors.initials: H
authors.lastname: Hatemi
mesh_terms: D000818:Animals; D004912:Erythrocytes / Q000737:chemistry* / Q000187:drug effects / Q000201:enzymology*; D005527:Food, Fortified; D005978:Glutathione / Q000097:blood* / Q000187:drug effects; D005979:Glutathione Peroxidase / Q000097:blood* / Q000187:drug effects; D007501:Iron / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000097:blood* / Q000187:drug effects; D013972:Thyrotropin / Q000097:blood / Q000187:drug effects; D013974:Thyroxine / Q000097:blood / Q000187:drug effects / Q000494:pharmacology*
chemical_list: D013972:Thyrotropin; D007501:Iron; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005978:Glutathione; D013974:Thyroxine