Recurrent thromboembolism as a hallmark of Cushing's syndrome.
The present report describes a 54-year-old woman with a history of recurrent thromboembolic events. The clinical and physical examination led to suspect Cushing's syndrome. Screening tests (urinary free cortisol excretion and 1 mg dexamethasone) were inconclusive, but a detailed endocrine work up confirmed the presence of ACTH-dependent hypercortisolism. The patient was cured by the removal of a ACTH-secreting microadenoma by transsphenoidal route. The present case provides a clinical demonstration of a previous experimental evidence that a hypercoagulable state is present in Cushing's syndrome.
La Brocca
A
A
Divisione di Medicina Interna, Ospedale Civile di Giaveno, Torino, Italy.
Terzolo
M
M
Pia
A
A
Paccotti
P
P
De Giuli
P
P
Angeli
A
A
D000236:Adenoma / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D003480:Cushing Syndrome / Q000473:pathology / Q000503:physiopathology* / Q000601:surgery; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood / Q000652:urine; D008875:Middle Aged; D010911:Pituitary Neoplasms / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D012008:Recurrence; D013923:Thromboembolism / Q000503:physiopathology* / Q000601:surgery
D006854:Hydrocortisone