title: [Enoximone in weaning from mechanical circulation support in pediatric patients].
abstract: OBJECTIVE
  To assess and record the response to continuous infusion of the phosphodiesterase inhibitor enoximone during weaning from mechanical circulatory support (MCS) and to verify the possibility of success with this indication in pediatric patients.
  
  
  METHODS
  Retrospective study.
  
  
  METHODS
  Pediatric cardiac surgery intensive care unit.
  
  
  METHODS
  Two pediatric patients operated for complex congenital heart disease with low cardiac output syndrome in the immediate postoperative period, evolved in cardiocirculatory arrest despite massive inotropic pharmacological support, and then assisted by mechanical circulatory support.
  
  
  METHODS
  Weaning from mechanical circulatory support with continuous infusion of enoximone, only in one case preceded by a loading dose and associated with catecholamine infusion.
  
  
  RESULTS
  During weaning hemodynamic parameters (LAP, CVP, MAP, HR), SvO2, diuresis, rectal and cutaneous temperatures were assessed and recorded. A serial echocardiographic assessment of left ventricular systolic and diastolic diameters and ejection fraction (EF%) has also been performed every 12 hours. Weaning from MCS using enoximone as inotropic support was possible in both cases.
  
  
  CONCLUSIONS
  Enoximone proved to be useful in weaning from MCS in two pediatric patients, despite the difficulty to assess its effect in one of the two cases in which enoximone was used together with high dosages of other inotropic drugs. These initial positive results urge us to further investigate applications of this drug in pediatric patients.
authors.affiliation: UO di Anestesia e Rianimazione-IFC CNR, Ospedale Pediatrico Apuano, Massa.
authors.forename: S
authors.initials: S
authors.lastname: Bevilacqua
authors.forename: P
authors.initials: P
authors.lastname: Del Sarto
authors.forename: G
authors.initials: G
authors.lastname: Tommasini
authors.forename: R
authors.initials: R
authors.lastname: Moschetti
authors.forename: L
authors.initials: L
authors.lastname: Scebba
authors.forename: B
authors.initials: B
authors.lastname: Murzi
authors.forename: M
authors.initials: M
authors.lastname: Genovesi
authors.forename: A
authors.initials: A
authors.lastname: Nicolini
authors.forename: F
authors.initials: F
authors.lastname: Santoli
mesh_terms: D001243:Assisted Circulation; D002303:Cardiac Output, Low / Q000601:surgery; D006348:Cardiac Surgical Procedures; D002316:Cardiotonic Agents / Q000627:therapeutic use*; D002675:Child, Preschool; D017335:Enoximone / Q000627:therapeutic use*; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007223:Infant; D008297:Male; D012189:Retrospective Studies
chemical_list: D002316:Cardiotonic Agents; D017335:Enoximone