[Age-related changes in the autonomic ganglia].
Ultrastructure of vegetative ganglions (neck-thoracic, intracardial and intestinal) of Wistar and SHR rats, 26-28 months of age was studied electron-microscopically. The most pronounced changes were found in the neck-thoracic ganglions where, apart from lipofuscin deposits, lamellar bodies were frequently found. Redistribution of neuromediators in the neuron body and an increase of the neuroactive substances release into the intercellular space of the ganglion occur with age. The data on possible postsynaptic influence on the presynapse by means of neuromediators are presented. Nissl bodies hypertrophy was observed in the neck-thoracic and intracardial ganglions of old SHR rats.
Sosunov
A A
AA
R. Virchov Institute of Pathology, Humboldt University, Berlin, Germany.
Krugliakov
P P
PP
SHvalev
V N
VN
Guski
G
G
Postnov
Iu V
IuV
D000375:Aging / Q000473:pathology*; D000818:Animals; D005725:Ganglia, Autonomic / Q000473:pathology*; D006321:Heart / Q000294:innervation; D006973:Hypertension / Q000473:pathology*; D007422:Intestines / Q000294:innervation; D008297:Male; D008854:Microscopy, Electron; D009474:Neurons / Q000473:pathology; D051381:Rats; D011918:Rats, Inbred SHR; D017208:Rats, Wistar; D013233:Stellate Ganglion / Q000473:pathology