title: Does histology influence outcome in childhood Hodgkin's disease? Results from the United Kingdom Children's Cancer Study Group.
abstract: OBJECTIVE
  Histology has been identified as an important prognostic factor in Hodgkin's disease (HD) in adults. Information regarding the impact of histology on outcome in childhood HD is scarce. This study determines the effect of histology on the overall survival (OS) or progression-free survival (PFS) in a national series of children treated in a standardized manner.
  
  
  METHODS
  The results of treatment of 331 assessable patients, treated between January 1, 1982 and June 30, 1992, in the United Kingdom Children's Cancer Study Group (UKCCSG) Hodgkin's study I were reviewed to evaluate OS, PFS, and deaths according to stage and histology. Treatment was either involved-field radiation alone (stage IA) or chlorambucil, vinblastine, procarbazine, and prednisolone (ChlVPP) chemotherapy with or without mediastinal radiation. All were clinically staged at diagnosis.
  
  
  RESULTS
  Nodular sclerosing (NS) HD was the most common histologic subtype (155 of 331 patients [47%]) and was uniformly distributed through all stages. Lymphocyte-depletion (LD) HD was extremely uncommon (< 1%). Mixed-cellularity (MC) HD had the highest relapse rate, but this was only significant (P < .05) in stage I patients who received local irradiation alone. There was no other statistically significant difference in OS and PFS between the various histologic subtypes. Multivariate analysis for PFS and OS confirmed that stage was the most important prognostic factor and that histology did not have an effect after stratification by stage.
  
  
  CONCLUSIONS
  This study demonstrates that with effective multiagent chemotherapy, histologic subtype does not influence outcome. The high relapse rates in stage I MC subtype indicates that MC HD is biologically aggressive and systemic treatment with or without local irradiation may be indicated. The high relapse rate in stage IV patients appeared to be independent of histology.
authors.affiliation: Paediatric Department, Royal Marsden Hospital, Sutton, Surrey, United Kingdom.
authors.forename: A G
authors.initials: AG
authors.lastname: Shankar
authors.forename: S
authors.initials: S
authors.lastname: Ashley
authors.forename: M
authors.initials: M
authors.lastname: Radford
authors.forename: A
authors.initials: A
authors.lastname: Barrett
authors.forename: D
authors.initials: D
authors.lastname: Wright
authors.forename: C R
authors.initials: CR
authors.lastname: Pinkerton
mesh_terms: D000206:Actuarial Analysis; D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D018572:Disease-Free Survival; D006689:Hodgkin Disease / Q000401:mortality* / Q000473:pathology* / Q000628:therapy; D006801:Humans; D009367:Neoplasm Staging; D011379:Prognosis; D012189:Retrospective Studies; D016019:Survival Analysis; D016896:Treatment Outcome; D006113:United Kingdom