title: (1 alpha, 2 beta, 3 beta, 4 alpha)-1,2-bis[N-propyl-N-(4-phenoxybenzyl) amino]carbonyl]cyclobutane-3,4-dicarboxylic acid (A-87049): a novel potent squalene synthase inhibitor.
authors.affiliation: Aging and Degenerative Diseases Research, Pharmaceutical Discovery, Abbott Laboratories, Illinois 60064-3500, USA.
authors.forename: A K
authors.initials: AK
authors.lastname: Fung
authors.forename: W R
authors.initials: WR
authors.lastname: Baker
authors.forename: S
authors.initials: S
authors.lastname: Fakhoury
authors.forename: H H
authors.initials: HH
authors.lastname: Stein
authors.forename: J
authors.initials: J
authors.lastname: Cohen
authors.forename: B G
authors.initials: BG
authors.lastname: Donner
authors.forename: D S
authors.initials: DS
authors.lastname: Garvey
authors.forename: K P
authors.initials: KP
authors.lastname: Spina
authors.forename: S H
authors.initials: SH
authors.lastname: Rosenberg
mesh_terms: D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D000924:Anticholesteremic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003998:Dicarboxylic Acids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013186:Farnesyl-Diphosphate Farnesyltransferase / Q000037:antagonists & inhibitors*; D005260:Female; D007202:Indicators and Reagents; D008148:Lovastatin / Q000494:pharmacology; D008252:Macaca fascicularis; D008297:Male; D015394:Molecular Structure; D013329:Structure-Activity Relationship
chemical_list: C106946:A 87049; D000577:Amides; D000924:Anticholesteremic Agents; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D003998:Dicarboxylic Acids; D004791:Enzyme Inhibitors; D007202:Indicators and Reagents; D002784:Cholesterol; D008148:Lovastatin; D013186:Farnesyl-Diphosphate Farnesyltransferase