title: Summing up, weak immunomodulating signals of Tahyna virus and immunomodulating drugs induce immunosuppression in mice.
abstract: The successive injection of non-immunomodulating doses of Tahyna virus (100 LD50) and non-immunomodulating doses of immunomodulating drugs, such as purified staphylococcal toxoid or glucosaminylmuramyldipeptide (Likopid), to mice were accompanied by a decrease in the IgM plaque-forming cell response to sheep red blood cells.
authors.affiliation: Gamaleya Research Institute of Epidemiology and Microbiology, Moscow, Russia.
authors.forename: I B
authors.initials: IB
authors.lastname: Semenova
authors.forename: A K
authors.initials: AK
authors.lastname: Kalenderov
authors.forename: V V
authors.initials: VV
authors.lastname: Vargin
authors.forename: B F
authors.initials: BF
authors.lastname: Semenov
mesh_terms: D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000031:analogs & derivatives / Q000494:pharmacology; D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D004306:Dose-Response Relationship, Immunologic; D002141:Encephalitis Virus, California / Q000276:immunology*; D007165:Immunosuppression Therapy; D051379:Mice; D008808:Mice, Inbred CBA; D013208:Staphylococcal Toxoid / Q000494:pharmacology
chemical_list: D000276:Adjuvants, Immunologic; D013208:Staphylococcal Toxoid; D000119:Acetylmuramyl-Alanyl-Isoglutamine; C063429:glucosaminylmuramyl-2-alanine-D-isoglutamine