The aging retarding effect of 'Long-Life CiLi'.
'Long-Life CiLi' ('CiLi') oral liquid, is composed of superoxide dismutase (SOD), polysacchairide, vitamin C, vitamin E and trace elements which were all extracted from a natural plant fruit Cili (Rosa roxburghii Tratt) in Guizhou, China. A set of indices were evaluated after administration of 'CiLi' 10 ml Bid, for two months in 50-75 years old healthy people, the mean value of NK cell activity (22.4 +/- 10.8-->27.5 +/- 12.9%, P < 0.05), SOD (453.0 +/- 24.2-->468.6 +/- 21.3 micrograms/gHb, P < 0.001), Catalase (15.5 +/- 1.7-->17.4 +/- 3.0 U/mgHb, P < 0.001) and GSH content (2.3 +/- 0.3-->2.6 +/- 0.5 mg/gHb, P < 0.001) in erythrocytes and 'delta CO, CI, SV, SI, LVET, LVETI and AC' values increased significantly, while the serum LPO level (4.20 +/- 0.78-->3.78 +/- 0.50 nmol/ml, P < 0.001), total microcirculation weighed value (1.87 +/- 1.0-->0.92 +/- 0.5, P < 0.001), delta PVR (-241.7 +/- 733.2-->187.9 +/- 938.2, P < 0.05) and the light reaction time (Simple RT, red light: 383 +/- 128-->332 +/- 68.9 ms, P < 0.05; selective RT: red light 709 +/- 287-->566 +/- 119 ms, P < 0.05; green light 639 +/- 162-->536 +/- 80 ms, P < 0.01) decreased significantly. There were no significant differences in the control group. The mean life span of fruit flies were significantly elongated for low, medium and high concentrations 'CiLi' treatment groups than in the control group (Female: 57.6 +/- 11.3-->62.1 +/- 12.8; 69.6 +/- 14.7; 62.6 +/- 12 days; P < 0.05 approximately 0.001. Male: 56.3 +/- 9.6-->64.9 +/- 12.4; 64.5 +/- 14.5; 64.8 +/- 14.1 days, P < 0.001). It is suggested that 'CiLi' has an aging retarding and geroprotection effect.
Ma
Y X
YX
Department of Aging and Antiaging, Shanghai Institute of Gerontology and Geriatrics, Huadong Hospital, People's Republic of China. du@iri.shlc.ac.cn
Zhu
Y
Y
Wang
C F
CF
Wang
Z S
ZS
Chen
S Y
SY
Shen
M H
MH
Gan
J M
JM
Zhang
J G
JG
Gu
Q
Q
He
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D000368:Aged; D000375:Aging / Q000187:drug effects*; D000818:Animals; D001205:Ascorbic Acid / Q000627:therapeutic use; D016022:Case-Control Studies; D004331:Drosophila melanogaster / Q000235:genetics; D005260:Female; D005609:Free Radicals; D006801:Humans; D007694:Killer Cells, Natural / Q000187:drug effects; D008136:Longevity / Q000187:drug effects*; D008297:Male; D008833:Microcirculation / Q000187:drug effects; D008875:Middle Aged; D010936:Plant Extracts / Q000627:therapeutic use*; D011134:Polysaccharides / Q000627:therapeutic use*; D013482:Superoxide Dismutase / Q000627:therapeutic use*; D014131:Trace Elements / Q000627:therapeutic use; D014810:Vitamin E / Q000627:therapeutic use; D014815:Vitamins / Q000627:therapeutic use*
D005609:Free Radicals; D010936:Plant Extracts; D011134:Polysaccharides; D014131:Trace Elements; D014815:Vitamins; D014810:Vitamin E; D013482:Superoxide Dismutase; D001205:Ascorbic Acid