Renal angiotensin-converting enzyme localization in diabetic rats and the effect of low protein diet.
Recent evidence suggests a role of angiotensin-converting enzyme (ACE) in diabetic nephropathy. The effect of diabetes and low protein diet on renal immunohistochemical ACE localization was studied in streptozotocin-induced DM rats. Immunohistochemical ACE localization was reduced in DM rats, and a low protein diet partially resolved this abnormality while inhibiting the progression of diabetic nephropathy.
Mizuiri
S
S
Department of Nephrology, Toho University School of Medicine, Ohta-ku Tokyo, Japan.
Kobayashi
M
M
Nakanishi
T
T
Yoshikawa
H
H
Miyagi
M
M
Tanegashima
M
M
Sakai
K
K
Hayashi
I
I
Fushimi
T
T
Hasegawa
A
A
D000419:Albuminuria; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure; D003921:Diabetes Mellitus, Experimental / Q000201:enzymology* / Q000473:pathology / Q000503:physiopathology; D003928:Diabetic Nephropathies / Q000201:enzymology* / Q000473:pathology / Q000517:prevention & control*; D018753:Diet, Protein-Restricted; D007150:Immunohistochemistry; D007668:Kidney / Q000201:enzymology* / Q000473:pathology; D008297:Male; D007703:Peptidyl-Dipeptidase A / Q000032:analysis*; D051381:Rats; D017208:Rats, Wistar; D012709:Serum Albumin / Q000378:metabolism; D013997:Time Factors
D001786:Blood Glucose; D012709:Serum Albumin; D007703:Peptidyl-Dipeptidase A