title: [Lacking effect of timing of surgery in relation to the menstrual cycle on prognosis of breast cancer in premenopausal women].
abstract: The influence of timing of surgery in relation to menstrual period on survival of breast cancer patients has been both advanced advocated and disputed. A meta-analysis on published series showed a statistically significant overall odds reduction when surgery is performed in the luteal phase. The records of 165 premenopausal M- breast cancer women, not on hormonal therapies, consecutively operated on from 1977 to 1991 were reviewed. All patients underwent modified radical mastectomies or quadrantectomies plus operative radiotherapy, Node-positive patients received standard adjuvant chemotherapy. Cox regression analysis was used to estimate the relative risk (RR) of death in three models including timing of surgery, age, histology, pathological T and N. In each model, patients were divided into two groups according to the criteria proposed by Badwe, Hrushesky, and Senie. Multivariate analysis showed a significant association between pT and pN and survival, whereas no association with survival was observed for timing of surgery according to Badwe or Hrushesky or Senie criteria (RR = 1.26, RR = 0.91, and RR = 0.88 respectively). Up-to-date agreement on the menstrual phase and relative expected better prognosis is still lacking.
authors.affiliation: Istituto di Clinica Chirurgia I, Università degli Studi di Genova.
authors.forename: G
authors.initials: G
authors.lastname: Mondini
authors.forename: D
authors.initials: D
authors.lastname: Friedman
authors.forename: F
authors.initials: F
authors.lastname: De Cian
authors.forename: C
authors.initials: C
authors.lastname: Spirito
authors.forename: S
authors.initials: S
authors.lastname: Carrabetta
authors.forename: M
authors.initials: M
authors.lastname: Costantini
authors.forename: M P
authors.initials: MP
authors.lastname: Sormani
authors.forename: D
authors.initials: D
authors.lastname: Civalleri
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000401:mortality / Q000532:radiotherapy / Q000601:surgery*; D018270:Carcinoma, Ductal, Breast / Q000401:mortality / Q000532:radiotherapy / Q000601:surgery*; D002909:Chronobiology Phenomena; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D015411:Mastectomy, Modified Radical; D015412:Mastectomy, Segmental; D008597:Menstrual Cycle; D008875:Middle Aged; D015999:Multivariate Analysis; D011182:Postoperative Care; D017697:Premenopause; D011379:Prognosis; D012044:Regression Analysis