Imaging of bronchial carcinoid tumors associated to Cushing syndrome with 111In-Octreoscan scintigraphy and immunoscintigraphy with anti-chromogranin monoclonal antibodies. Report of two cases.
Bronchial carcinoid tumors are neuroendocrine neoplasms capable of expressing somatostatin receptors and of secreting neuromediators such as ACTH and chromogranins. Radiologic appearance is usually non-specific and has to be distinguished from benign pulmonary nodules and other malignant diseases. Standard radiological techniques have limited accuracy in the evaluation of such lesions. Radioisotopic imaging techniques may increase the specificity of diagnostic assessment. The role of immunoscintigraphy with anti-chromogranin A and B monoclonal antibodies (MoAbs) and of 111In-Octreoscan scintigraphy is evaluated in two cases of bronchial carcinoid tumors associated to Cushing syndrome.
Carretta
A
A
Department of Cardiothoracic Surgery, San Raffaele Hospital, Milan, Italy.
Chiesa
G
G
Magnani
P
P
Songini
C
C
Melloni
G
G
Zannini
P
P
Grossi
A
A
D000293:Adolescent; D001984:Bronchial Neoplasms / Q000150:complications / Q000000981:diagnostic imaging*; D002276:Carcinoid Tumor / Q000150:complications / Q000000981:diagnostic imaging*; D053379:Chromogranin A; D002864:Chromogranins / Q000276:immunology; D003480:Cushing Syndrome / Q000150:complications*; D005260:Female; D006801:Humans; D007205:Indium Radioisotopes; D008297:Male; D015282:Octreotide / Q000031:analogs & derivatives*; D004369:Pentetic Acid / Q000031:analogs & derivatives*; D016719:Radioimmunodetection; D019275:Radiopharmaceuticals
D053379:Chromogranin A; D002864:Chromogranins; D007205:Indium Radioisotopes; D019275:Radiopharmaceuticals; C071632:SDZ 215-811; D004369:Pentetic Acid; D015282:Octreotide