title: Protection of mice against Schistosoma mansoni infection by passive transfer of sera from infected rabbits.
abstract: Sera from rabbits infected with unattenuated Schistosoma mansoni cercariae conferred significant levels of protection against S. mansoni challenge (P < 0.001) after passive transfer to mice. Infected rabbit sera were only effective in conferring protection when transferred during the first week of infection, and were not effective when administered against liver-stage worms. Immunoglobulins isolated from the infected rabbit sera with Protein A-Sepharose were shown to be responsible for the transfer of protection to mice. Immunofluorescence studies demonstrated that the sera were more reactive against the surface of three hour-old mechanically transformed schistosomula than against the surfaces of lung-stage schistosomula. The sera from infected rabbits reacted polyspecifically against antigens in cercaria, schistosomula, and the worm and egg stages of the S. mansoni life-cycle. The host parasite relationship of S. mansoni in the rabbit is discussed.
authors.affiliation: School of Biological Sciences, University of Wales, Bangor, Gwynedd, UK.
authors.forename: P G
authors.initials: PG
authors.lastname: Fallon
authors.forename: R E
authors.initials: RE
authors.lastname: Fookes
authors.forename: M J
authors.initials: MJ
authors.lastname: Doenhoff
mesh_terms: D000818:Animals; D000909:Antibodies, Helminth / Q000008:administration & dosage / Q000097:blood; D005260:Female; D019084:Fluorescent Antibody Technique, Indirect; D006790:Host-Parasite Interactions / Q000276:immunology; D007116:Immunization, Passive; D007814:Larva / Q000276:immunology; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D011817:Rabbits; D012550:Schistosoma mansoni / Q000254:growth & development / Q000276:immunology*; D012555:Schistosomiasis mansoni / Q000276:immunology* / Q000517:prevention & control*
chemical_list: D000909:Antibodies, Helminth