title: Postnatal development of the harderian gland in the rabbit: light and electron microscopic observations.
abstract: We have investigated the development of the Harderian glands of Japanese white rabbits from birth to 4 months of age. Although two types of secretory cells comprise the glandular epithelium of the pink and white lobes in fully developed glands, the time of neonatal appearance is different between the two. Cells consisting of the pink lobe first appear on the third day of life, while cells of the white appear around seventh day of life. The ultrastructure of the Harderian glands from 1-week-old rabbits resembles that of adult animals. The gland can be divided into three parts on the basis of their epithelial cell composition at the electron microscopic level. The respective parts are composed of: (1) one type of cells with large vacuoles (pink lobe), (2) one type of cells with small vacuoles (white lobe), and (3) two types of cells with large and small vacuoles (pink-white mixed portion). The relative number of plasma cells per 1 mm2 is low in both pink and white lobes during early postnatal life. However, in adult animals, the white lobe has a larger number of plasma cells than the pink lobe. These results suggest the possibility that the white lobe participates in the immune system more than does the pink.
authors.affiliation: Department of Anatomy, Tokyo Medical College Shinjuku-ku, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Shirama
authors.forename: S
authors.initials: S
authors.lastname: Ozawa
authors.forename: Y
authors.initials: Y
authors.lastname: Seyama
authors.forename: M
authors.initials: M
authors.lastname: Kobayashi
authors.forename: S
authors.initials: S
authors.lastname: Sawamura
authors.forename: J
authors.initials: J
authors.lastname: Yamada
mesh_terms: D000818:Animals; D002452:Cell Count; D004847:Epithelial Cells; D004848:Epithelium / Q000254:growth & development / Q000648:ultrastructure; D005260:Female; D006243:Harderian Gland / Q000166:cytology / Q000254:growth & development* / Q000648:ultrastructure; D008297:Male; D010950:Plasma Cells / Q000276:immunology / Q000648:ultrastructure; D011817:Rabbits / Q000033:anatomy & histology*; D014617:Vacuoles / Q000648:ultrastructure