title: Global cerebral blood flow during infusion of adenosine in humans: assessment by magnetic resonance imaging and positron emission tomography.
abstract: Adenosine, an endogenous vasodilator, induces a cerebral vasodilation at hypotensive infusion rates in anaesthetized humans. At lower doses (< 100 micrograms kg-1 min-1), adenosine has shown to have an analgesic effect. This study was undertaken to investigate whether a low dose, causing tolerable symptoms of peripheral vasodilation affects the global cerebral blood flow (CBF). In nine healthy volunteers CBF measurements were made using axial magnetic resonance (MR) phase images of the internal carotid and vertebral arteries at the level of C2-3. Quantitative assessment of CBF was also obtained with positron emission tomography (PET) technique, using intravenous bolus [15O]butanol as tracer in four of the subject at another occasion. During normoventilation (5.4 +/- 0.2 kPa, mean +/- s.e.m.), the cerebral blood flow measured by magnetic resonance imaging technique, as the sum of the flows in both carotid and vertebral arteries, was 863 +/- 66 mL min-1, equivalent to about 64 +/- 5 mL 100 g-1 min-1. The cerebral blood flow measured by positron emission tomography technique, was 59 +/- 4 mL 100 g-1 min-1. All subjects had a normal CO2 reactivity. When adenosine was infused (84 +/- 7 micrograms kg-1 min-1.) the cerebral blood flow, measured by magnetic resonance imaging was 60 +/- 5 mL 100 g-1 min-1. The end tidal CO2 level was slightly lower (0.2 +/- 0.1 kPa) during adenosine infusion than during normoventilation. In the subgroup there was no difference in cerebral blood flow as measured by magnetic resonance imaging or positron emission tomography. In conclusion, adenosine infusion at tolerable doses in healthy volunteers does not affect global cerebral blood flow in unanaesthetized humans.
authors.affiliation: Department of Anaesthesiology and Intensive Care, Karolinska Hospital, Stockholm, Sweden.
authors.forename: K
authors.initials: K
authors.lastname: Stånge
authors.forename: D
authors.initials: D
authors.lastname: Greitz
authors.forename: M
authors.initials: M
authors.lastname: Ingvar
authors.forename: T
authors.initials: T
authors.lastname: Hindmarsh
authors.forename: A
authors.initials: A
authors.lastname: Sollevi
mesh_terms: D000241:Adenosine / Q000008:administration & dosage / Q000494:pharmacology* / Q000502:physiology; D000328:Adult; D002343:Carotid Artery, Internal / Q000187:drug effects / Q000502:physiology; D002560:Cerebrovascular Circulation / Q000187:drug effects* / Q000502:physiology; D005260:Female; D006801:Humans; D006985:Hyperventilation / Q000503:physiopathology; D007262:Infusions, Intravenous; D018810:Magnetic Resonance Angiography; D008297:Male; D014055:Tomography, Emission-Computed; D014664:Vasodilation / Q000187:drug effects / Q000502:physiology; D014711:Vertebral Artery / Q000187:drug effects / Q000502:physiology
chemical_list: D000241:Adenosine