title: Clinical assessment of functional stenosis severity: use of coronary pressure measurements for the decision to bypass a lesion.
abstract: BACKGROUND
  In the selection of patients eligible for minimally invasive coronary artery bypass grafting (MICABG), knowledge about the pathophysiologic significance of individual coronary stenoses is important. Only if the lesion amenable to MICABG can be identified as the culprit lesion, and other lesions can be demonstrated not to be responsible for reversible ischemia, will MICABG be an appropriate procedure.
  
  
  METHODS
  By simultaneous measurement of mean aortic pressure and transstenotic coronary pressure, a pathophysiologic index can be obtained that specifically indicates the influence of an epicardial coronary stenosis on maximum achievable blood flow of the supplied myocardial territory. This index is called myocardial fractional flow reserve (FFR(myo)).
  
  
  RESULTS
  Myocardial fractional flow reserve is a reliable, lesion-specific index for determining whether a particular stenosis is responsible for reversible myocardial ischemia. If FFR(myo) is less than 0.75, revascularization is indicated, whereas if FFR(myo) is greater than 0.75, revascularization usually is not warranted. Moreover, in contrast to classic coronary flow or flow velocity reserve, FFR(myo) is independent of changes in heart rate, blood pressure, and contractility, and also accounts for the contribution of collaterals.
  
  
  CONCLUSIONS
  Pressure-derived FFR(myo) is an accurate pathophysiologic index for reliable identification of functionally significant epicardial lesions and can be obtained easily and quickly during routine cardiac catheterization. Therefore, FFR(myo) facilitates clinical decision-making with respect to the appropriateness of MICABG.
authors.affiliation: Department of Cardiology, Catharina Hospital, Eindhoven, the Netherlands.
authors.forename: N H
authors.initials: NH
authors.lastname: Pijls
authors.forename: G J
authors.initials: GJ
authors.lastname: Bech
authors.forename: B
authors.initials: B
authors.lastname: De Bruyne
authors.forename: A
authors.initials: A
authors.lastname: van Straten
mesh_terms: D000368:Aged; D001783:Blood Flow Velocity; D001794:Blood Pressure; D003251:Constriction, Pathologic; D001026:Coronary Artery Bypass; D003326:Coronary Circulation; D003327:Coronary Disease / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D003331:Coronary Vessels / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019060:Minimally Invasive Surgical Procedures; D009200:Myocardial Contraction