[Topographical diagnosis of insulinoma of the pancreas. Value of the test of intra-arterial calcium infusion].
OBJECTIVE
The localization of insulinomas is a central problem, because none of the imaging techniques has proved sufficiently reliable for the diagnosis of tumors smaller than 2 cms.


METHODS
Calcium stimulation test was performed during selective pancreatic angiogram with calcium gluconate injection in the pancreatic arteries, e.g. gastroduodenal, superior mesenteric and splenic. A simultaneous catheterization of hepatic veins through the femoral vein allowed measurement of insulin level increment after calcium stimulation.


RESULTS
In our experience, this test allowed a positive location of an insulinoma in three consecutive patients presenting with organic hypoglycemia, and was useful for surgeons while non-invasive imaging techniques failed to locate the tumor in any of the three patients.


CONCLUSIONS
The calcium stimulation test is a reliable preoperative procedure, particularly when other imaging techniques fail to locate the tumor. However it remains invasive, and our data are still too preliminary to clearly define its place within imaging techniques.
Reznik
Y
Y
Service d'Endocrinologie et Maladies métaboliques, CHU Côte de Nacre, Caen.
Coffin
C
C
Courtheoux
P
P
Schletzer-Mari
A
A
Roland-Billecart
D
D
Mahoudeau
J
J
D000328:Adult; D000368:Aged; D000792:Angiography; D002118:Calcium / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007261:Infusions, Intra-Arterial; D007328:Insulin / Q000097:blood; D007340:Insulinoma / Q000097:blood / Q000175:diagnosis*; D008297:Male; D010190:Pancreatic Neoplasms / Q000097:blood / Q000175:diagnosis*; D013268:Stimulation, Chemical
D007328:Insulin; D002118:Calcium