[Systematic analysis of basic drugs in plasma using X-5 solid-phase extraction GC-FID and GC-MS].
A systematic determination method for 34 basic drugs in human plasma is described. Drugs were extracted from plasma at pH 10 using X-5 resin as adsorbent, then identified and quantitated by capillary GC-FID and GC-MS. The detection limits for most drugs are in the range of 0.5-2.0 micrograms.ml-1. Precision and linearity of the method are satisfactory for clinical toxicological applications.
Qiu
F H
FH
Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing.
Liu
L
L
Luo
Y
Y
Liu
F
F
Lu
Y Q
YQ
D000701:Analgesics, Opioid / Q000097:blood*; D000929:Antidepressive Agents, Tricyclic / Q000097:blood*; D014150:Antipsychotic Agents / Q000097:blood*; D002110:Caffeine / Q000097:blood; D000697:Central Nervous System Stimulants / Q000097:blood; D002849:Chromatography, Gas / Q000379:methods; D003975:Diazepam / Q000097:blood; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D006993:Hypnotics and Sedatives / Q000097:blood; D008614:Meperidine / Q000097:blood*; D010640:Phenothiazines
D000701:Analgesics, Opioid; D000929:Antidepressive Agents, Tricyclic; D014150:Antipsychotic Agents; D000697:Central Nervous System Stimulants; D006993:Hypnotics and Sedatives; D010640:Phenothiazines; D002110:Caffeine; D008614:Meperidine; D003975:Diazepam