title: A polymorphism in the presenilin 1 gene does not modify risk for Alzheimer's disease in a cohort with sporadic early onset.
abstract: Mutations in the presenilin 1 gene account for many cases of early onset familial Alzheimer's disease. Homozygosity for the 'T' allele of a polymorphism in the presenilin 1 gene has previously been reported to double the risk for Alzheimer's disease in a late onset Caucasian sample. Here we report that this polymorphism does not incur risk in a case control sample of early onset Alzheimer's disease, possibly suggesting a different disease etiology between the early and late onset forms.
authors.affiliation: Department of Psychiatry, Washington University Medical School, St. Louis, MO 63110, USA. lendon@icarus.wustl.edu
authors.forename: C L
authors.initials: CL
authors.lastname: Lendon
authors.forename: A
authors.initials: A
authors.lastname: Myers
authors.forename: A
authors.initials: A
authors.lastname: Cumming
authors.forename: A M
authors.initials: AM
authors.lastname: Goate
authors.forename: D
authors.initials: D
authors.lastname: St Clair
mesh_terms: D000328:Adult; D017668:Age of Onset; D000368:Aged; D000483:Alleles; D000544:Alzheimer Disease / Q000453:epidemiology / Q000235:genetics* / Q000523:psychology; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics / Q000378:metabolism; D004247:DNA / Q000032:analysis; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000502:physiology*; D053764:Presenilin-1; D012306:Risk; D012606:Scotland / Q000453:epidemiology
chemical_list: D053327:Apolipoprotein E4; D001057:Apolipoproteins E; D008565:Membrane Proteins; C508853:PSEN1 protein, human; D053764:Presenilin-1; D004247:DNA