Sequence of a new HLA-DR allele, DRB5*0106.
We report here the exon 2 sequence of a new HLA-DRB5 allele, DRB5*0106, that was identified in two volunteer bone marrow donors from the Swiss national registry. This new allele differs from DRB5*0101 by five amino acids at positions 67, 70, 71, 85 and 86. It is associated with DRB1*1501 and DQB1*0602. This unusual DRB1*1501-DRB5*0106 association increases the complexity of the DR2 group, although it appears to be very rare, at least in our population. HLA-DRB5*0106 can be readily detected upon DR generic oligotyping, provided the two probes that mark the major DRB5 subtypes, DRB5*0101 and DRB5*02, respectively, are included in the assay.
Kervaire
B
B
Transplantation Immunology Unit, Division of Immunology and Allergology, HUG, Geneva, Switzerland.
Tiercy
J-M
JM
Transplantation Immunology Unit, Division of Immunology and Allergology, HUG, Geneva, Switzerland.
D000483:Alleles; D000595:Amino Acid Sequence; D001483:Base Sequence; D001854:Bone Marrow Cells; D004247:DNA / Q000302:isolation & purification; D015343:DNA Probes, HLA / Q000235:genetics; D005091:Exons; D005260:Female; D006684:HLA-DR Antigens / Q000235:genetics*; D006650:Histocompatibility Testing; D006801:Humans; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D017422:Sequence Analysis, DNA; D013557:Switzerland; D044465:White People / Q000235:genetics
D015343:DNA Probes, HLA; D006684:HLA-DR Antigens; D004247:DNA