[The effect of a modification to the lipopolysaccharide of Yersinia pestis on its neutrophilokine-inducing activity].
The ability of the isolated and modified Yersinia pestis LPS to induce the synthesis of the neutrophilokines that regulate the macrophage functional activity was studied. It is established that the Y. pestis LPS detoxication, especially by the method of deacylation, does not lead to the decrease in biological, in particular neutrophilokine-inducing activity of these preparations, but actually even increases it. These results are in agreement with many reports showing the possibility of decreasing the LPS toxicity without reducing immunostimulatory activity of this important component of the outer membrane of gram-negative bacteria.
Vasil'eva
G I
GI
Bespalova
I A
IA
Kiseleva
A K
AK
Verkina
L M
LM
Doroshenko
E P
EP
Piatibratov
A M
AM
D000818:Animals; D002634:Chemotaxis, Leukocyte / Q000187:drug effects; D016207:Cytokines / Q000096:biosynthesis / Q000187:drug effects*; D004926:Escherichia coli; D006168:Guinea Pigs; D007928:Lethal Dose 50; D008070:Lipopolysaccharides / Q000302:isolation & purification / Q000494:pharmacology* / Q000633:toxicity; D017737:Macrophages, Peritoneal / Q000187:drug effects / Q000276:immunology; D051379:Mice; D009504:Neutrophils / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism; D010587:Phagocytosis / Q000187:drug effects; D010931:Plague Vaccine; D012397:Rosette Formation; D013329:Structure-Activity Relationship; D015010:Yersinia pestis
D016207:Cytokines; D008070:Lipopolysaccharides; D010931:Plague Vaccine