title: [Hematologic manifestations related to hepatitis A virus. 3 cases].
abstract: We report 3 cases of acute hepatitis A infection with haematological manifestations. In the first case, severe aplastic anemia occurred in a 6 year-old child, who underwent 3 bone marrow grafts before responding favourably. In the second and third cases, severe anemia and thrombocytopenia occurred in a 42 year-old man with cholestatic hepatitis, and in a 66 year-old man with fulminant hepatitis; there was a favourable outcome in both cases. These cases demonstrate that haematological manifestations in hepatitis A can be severe, independent of the severity of liver disease. Although these manifestations seem to be rare, we suggest performing systematic haematological evaluations in cases of viral hepatitis A with unusual outcomes.
authors.affiliation: Service d'Hépato-Gastroentérologie, CHU, Angers.
authors.forename: M Y
authors.initials: MY
authors.lastname: Maiga
authors.forename: F
authors.initials: F
authors.lastname: Oberti
authors.forename: H
authors.initials: H
authors.lastname: Rifflet
authors.forename: N
authors.initials: N
authors.lastname: Ifrah
authors.forename: P
authors.initials: P
authors.lastname: Calès
mesh_terms: D000328:Adult; D000368:Aged; D000740:Anemia / Q000209:etiology / Q000503:physiopathology / Q000628:therapy; D002648:Child; D006402:Hematologic Diseases / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy; D006506:Hepatitis A / Q000150:complications* / Q000503:physiopathology / Q000628:therapy; D006801:Humans; D008297:Male; D013921:Thrombocytopenia / Q000209:etiology / Q000503:physiopathology / Q000628:therapy