title: Effect of maternal CD4+ cell count, acquired immunodeficiency syndrome, and viral load on disease progression in infants with perinatally acquired human immunodeficiency virus type 1 infection. New York City Perinatal HIV Transmission Collaborative Study Group.
abstract: Among a cohort of 152 infants perinatally infected with human immunodeficiency virus type 1, and their mothers, we correlated infant outcome with material CD4+ lymphocyte count and the presence of maternal acquired immunodeficiency syndrome near delivery. In a subset of 50 mother-infant pairs, we also correlated infant outcome with maternal quantitative viral burden as measured by the nucleic acid sequence based amplification system. We found that low maternal CD4+ cell count and high viral burden were associated with decreased time to category C disease or death in infants infected with human immunodeficiency virus type 1. In a multivariate analysis, high maternal viral load and maternal acquired immunodeficiency syndrome were independently associated with shorter time to category C disease or death in infants with human immunodeficiency virus type 1 infection. High viral load in pregnant women, independent of the presence of advanced maternal disease, appears to increase the risk of rapidly progressive disease in their infected offspring.
authors.affiliation: Department of Pediatrics, Bronx Lebanon Hospital Center, NY 10457, USA.
authors.forename: G
authors.initials: G
authors.lastname: Lambert
authors.forename: D M
authors.initials: DM
authors.lastname: Thea
authors.forename: V
authors.initials: V
authors.lastname: Pliner
authors.forename: R W
authors.initials: RW
authors.lastname: Steketee
authors.forename: E J
authors.initials: EJ
authors.lastname: Abrams
authors.forename: P
authors.initials: P
authors.lastname: Matheson
authors.forename: P A
authors.initials: PA
authors.lastname: Thomas
authors.forename: B
authors.initials: B
authors.lastname: Greenberg
authors.forename: T M
authors.initials: TM
authors.lastname: Brown
authors.forename: M
authors.initials: M
authors.lastname: Bamji
authors.forename: M L
authors.initials: ML
authors.lastname: Kalish
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000175:diagnosis* / Q000188:drug therapy; D000998:Antiviral Agents / Q000008:administration & dosage / Q000627:therapeutic use; D018791:CD4 Lymphocyte Count; D005260:Female; D015497:HIV-1 / Q000302:isolation & purification*; D006801:Humans; D007231:Infant, Newborn; D008429:Maternal Welfare; D016133:Polymerase Chain Reaction; D011247:Pregnancy; D012367:RNA, Viral; D019562:Viral Load; D015215:Zidovudine / Q000008:administration & dosage / Q000627:therapeutic use
chemical_list: D000998:Antiviral Agents; D012367:RNA, Viral; D015215:Zidovudine