Antifungal activity of organic and organometallic derivatives of benzimidazole and benzothiazole.
Forty organic or organometallic derivatives of benzimidazole and benzothiazole and five rhodium(I) and ruthenium(II) complexes were evaluated for their in vitro antifungal activity against Candida albicans. Four of the tested compounds, the rhodium containing compounds 30, 31, 32 and 33, were found effective at the minimum inhibitory concentrations(MICs) between 400-600 micrograms/ml.
Küçükbay
H
H
Department of Chemistry, Faculty of Science and Literature, Inönü University, Malatya, Turkey.
Durmaz
B
B
D000935:Antifungal Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D001562:Benzimidazoles / Q000138:chemical synthesis / Q000494:pharmacology*; D052160:Benzothiazoles; D002176:Candida albicans / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000494:pharmacology*; D013844:Thiazoles / Q000138:chemical synthesis / Q000494:pharmacology*
D000935:Antifungal Agents; D001562:Benzimidazoles; D052160:Benzothiazoles; D009942:Organometallic Compounds; D013844:Thiazoles; C005465:benzothiazole