Circadian rhythms in mouse suprachiasmatic nucleus explants on multimicroelectrode plates.
The suprachiasmatic nucleus (SCN) of the mammalian hypothalamus functions as a circadian pacemaker. This study used multimicroelectrode plates to measure extracellular action potential activity simultaneously from multiple sites within the cultured mouse SCN. Neurons within the isolated mouse SCN expressed a circadian rhythm in spontaneous firing rate for weeks in culture.
Herzog
E D
ED
University of Virginia, Department of Biology, Center for Biological Timing, Charlottesville 22903, USA. edh3f@virginia.edu
Geusz
M E
ME
Khalsa
S B
SB
Straume
M
M
Block
G D
GD
D000200:Action Potentials; D000818:Animals; D002478:Cells, Cultured; D002940:Circadian Rhythm; D004594:Electrophysiology; D005110:Extracellular Space / Q000502:physiology; D051379:Mice; D008810:Mice, Inbred C57BL; D008839:Microelectrodes; D009474:Neurons / Q000502:physiology; D013493:Suprachiasmatic Nucleus / Q000166:cytology / Q000502:physiology*