[Studies on preparation and characteristics of cisplatin chitosan microspheres].
In this paper, the preparation, drug content, size and size distribution, appearance and morphology, release characteristics in vitro and degradation characteristics of cisplatin chitosan microspheres (CDDP-DAC-MS) were studied. CDDP-DAC-MS were prepared by emulsion-crosslink technique. The CDDP-DAC-MS was shown to have rough spherical surface under scanning electron microscopy. The average diameter of the microspheres was 74.80 microns and CDDP content was 20.83% +/- 0.36%. CDDP-DAC-MS swelled slightly in saline after 1 h. Within the test period, the release of CDDP from CDDP-DAC-MS in saline solution could be described by first-order equation. The microspheres were sterilized by 60Co radiation. After 28 d of hepatic artery embolization with CDDP-DAC-MS in dogs, pathological photomicrograph showed that CDDP-DAC-MS could still be observed.
Wang
Y M
YM
Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing.
Shi
T S
TS
Pu
Y L
YL
Zhu
J G
JG
Zhao
Y L
YL
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics; D002686:Chitin / Q000008:administration & dosage / Q000031:analogs & derivatives; D048271:Chitosan; D002945:Cisplatin / Q000008:administration & dosage* / Q000493:pharmacokinetics; D003692:Delayed-Action Preparations; D004285:Dogs; D004337:Drug Carriers; D008099:Liver / Q000378:metabolism; D008863:Microspheres
D000970:Antineoplastic Agents; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D002686:Chitin; D048271:Chitosan; D002945:Cisplatin