Absence of endocardial lymphoid infiltrates (Quilty lesions) in nonheart transplant recipients treated with cyclosporine.
The clinical records and autopsy material from 14 patients treated with cyclosporine who were not recipients of cardiac allografts were reviewed to further study the nature of endocardial lymphoid infiltrates (quilty lesions). Although there was well-documented exposure to cyclosporine, no endocardial lymphoid infiltrates were identified in these cases, providing evidence that the endocardial-based Quilty lesion is not the result of the direct effect of cyclosporine and may represent a localized form of heart rejection confined to the endocardium.
Barone
J H
JH
Department of Pathology, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA.
Fishbein
M C
MC
Czer
L S
LS
Blanche
C
C
Trento
A
A
Luthringer
D J
DJ
D000293:Adolescent; D000328:Adult; D000368:Aged; D001706:Biopsy; D009202:Cardiomyopathies / Q000139:chemically induced* / Q000473:pathology; D016572:Cyclosporine / Q000009:adverse effects* / Q000627:therapeutic use; D004699:Endocardium / Q000187:drug effects / Q000473:pathology; D005260:Female; D006084:Graft Rejection / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D016030:Kidney Transplantation / Q000473:pathology; D016031:Liver Transplantation / Q000473:pathology; D016040:Lung Transplantation / Q000473:pathology; D008218:Lymphocytosis / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D019310:Pseudolymphoma / Q000139:chemically induced* / Q000473:pathology; D013789:Thalassemia / Q000188:drug therapy / Q000473:pathology
D007166:Immunosuppressive Agents; D016572:Cyclosporine