[The effect of epsilon-aminocaproic acid and prednisolone on the activation of the complement system due to x-ray contrast agents in rats in vitro].
epsilon-Aminocaproic acid and prednisolone in concentration of 3.0 x 10(-5) M are proven to reduce or even completely prevent activation of the alternative pathway of the component which has been induced by iod-amide adipiodone and triombrast in concentrations 2.5 x 10(-2) M in the serum of "sensitive" rats. The preventive effect of the glucocorticoid appeared less pronounced. There exists direct positive correlation between the degree of the component activation with radiopaque compounds and preventive effect of the drugs studied.
Napolov
Iu K
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D015119:Aminocaproic Acid / Q000494:pharmacology*; D000818:Animals; D003170:Complement Pathway, Alternative / Q000187:drug effects*; D003287:Contrast Media / Q000009:adverse effects / Q000494:pharmacology*; D003974:Diatrizoate Meglumine / Q000009:adverse effects / Q000494:pharmacology*; D004347:Drug Interactions; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D004950:Esterases / Q000037:antagonists & inhibitors*; D005260:Female; D005938:Glucocorticoids / Q000494:pharmacology*; D007451:Iodamide / Q000009:adverse effects / Q000494:pharmacology*; D007458:Iodipamide / Q000009:adverse effects / Q000494:pharmacology*; D008297:Male; D011239:Prednisolone / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D018709:Statistics, Nonparametric
D003287:Contrast Media; D004791:Enzyme Inhibitors; D005938:Glucocorticoids; D003974:Diatrizoate Meglumine; D007451:Iodamide; D011239:Prednisolone; D004950:Esterases; D007458:Iodipamide; D015119:Aminocaproic Acid