title: [Immunologic fetal and neonatal immaturity: influence on the clinical course of HIV-1 infection in children].
abstract: Children born to HIV-1 infected mothers present a more severe clinical evolution than adults or children infected by other routes. The physiologic immaturity of the fetal and neonatal immune systems at the time of the infection probably plays an essential role in the progression of HIV-1 infection in these children. This paper describes the development of the normal human immune system and its correlation with the immunopathogenicity of vertical acquired immunodeficiency syndrome (AIDS).
authors.affiliation: Departamento de Imunologia, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro.
authors.forename: M B
authors.initials: MB
authors.lastname: Ortigão-de-Sampaio
authors.forename: L R
authors.initials: LR
authors.lastname: Castello-Branco
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology* / Q000635:transmission; D000917:Antibody Formation / Q000502:physiology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005315:Fetal Diseases / Q000276:immunology*; D015497:HIV-1; D006801:Humans; D007111:Immunity, Cellular / Q000276:immunology*; D007223:Infant; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical; D011247:Pregnancy