[The cardiotoxic properties of anti-arrhythmia agents].
Experiments were conducted on cats to study the cardiotoxic and arrhythmogenic properties of some antiarrhythmic agents in continuous intravenous infusion in doses multiple of the dose which causes an antiarrhythmic effect on an acontic model of arrhythmia in rats in 50% of cases. Novocainamide, cordarone, bonnecor, and quinidine possessed the most marked cardiotoxicity. A less marked cardiodepressive activity was encountered in the case of ethmosine and ethacysin. The appearance of the cardiodepressive properties of the agents depended on the rate of their injection. The results of the study testify to the possibility of prognosticating the arrhythmogenic and cardiodepressive effects in experimental investigation of new antiarrhythmic agents.
Spasov
A A
AA
Gurova
N A
NA
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage / Q000633:toxicity*; D001145:Arrhythmias, Cardiac / Q000139:chemically induced; D002415:Cats; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D005260:Female; D006321:Heart / Q000187:drug effects* / Q000503:physiopathology; D006439:Hemodynamics / Q000187:drug effects; D007262:Infusions, Intravenous; D007928:Lethal Dose 50; D008297:Male
D000889:Anti-Arrhythmia Agents