title: Does the in-vitro efficiency of meso-tetrahydroxy-phenyl-chlorin depend on pre-treatment of sensitizer?
abstract: The efficiency of a new photosensitizer of the second generation, meso-tetra-hydroxyphenyl-chlorin (mTHPC), which has a strong absorption at 652 nm, was investigated by oxygen consumption measurements and membrane integrity testing. The experiments proved a great increase in the efficiency of mTHPC after preincubation at 37 degrees C for 24 hours. From these findings it can be assumed that tumor cells can be treated in an optimal way with PDT after a longer delay following drug administration.
authors.affiliation: Department of Physics and Biophysics, University of Salzburg, Austria.
authors.forename: D M
authors.initials: DM
authors.lastname: Fiedler
authors.forename: F
authors.initials: F
authors.lastname: Wierrani
authors.forename: G
authors.initials: G
authors.lastname: Schnitzhofer
authors.forename: J C
authors.initials: JC
authors.lastname: Stewart
authors.forename: K
authors.initials: K
authors.lastname: Gharehbaghi
authors.forename: W
authors.initials: W
authors.lastname: Grünberger
authors.forename: B
authors.initials: B
authors.lastname: Krammer
mesh_terms: D002460:Cell Line; D002462:Cell Membrane / Q000187:drug effects; D005347:Fibroblasts / Q000187:drug effects / Q000378:metabolism; D006415:Hematoporphyrins; D006801:Humans; D008652:Mesoporphyrins / Q000494:pharmacology*; D008858:Microscopy, Phase-Contrast; D010101:Oxygen Consumption / Q000187:drug effects; D017319:Photosensitizing Agents / Q000494:pharmacology*
chemical_list: D006415:Hematoporphyrins; D008652:Mesoporphyrins; D017319:Photosensitizing Agents; C071875:photosan III; C072269:temoporfin