title: Congenital hemangiopericytoma/infantile myofibromatosis: radical surgery versus a conservative "wait and see" approach.
abstract: Infantile/congenital hemangiopericytoma, although sharing many similar histological features with adult hemangiopericytoma, has a much better prognosis. Nevertheless, most cases described in the literature were pursued by radical surgery with or without adjuvant chemotherapy. We describe a neonate who presented with a huge mass in the right gluteus, 6 x 5 x 4 cm, and a small ventral abdominal mass. The masses were confirmed on biopsy according to light microscopy, immunohistochemistry, and electron microscopy as congenital hemangiopericytoma. They shrank spontaneously within 2 weeks and vanished within 2 months. We present a hypothesis that masses appearing in the neonatal period with this histology and with no life-endangering pressure on vital organs should routinely be dealt with conservatively.
authors.affiliation: Pediatric Hemato/Oncology Department, Chaim Sheba Medical Center, Tel-Hashomer, Israel.
authors.forename: A
authors.initials: A
authors.lastname: Toren
authors.forename: M
authors.initials: M
authors.lastname: Perlman
authors.forename: S
authors.initials: S
authors.lastname: Polak-Charcon
authors.forename: I
authors.initials: I
authors.lastname: Avigad
authors.forename: M
authors.initials: M
authors.lastname: Katz
authors.forename: Y
authors.initials: Y
authors.lastname: Kuint
authors.forename: G
authors.initials: G
authors.lastname: Rechavi
mesh_terms: D000328:Adult; D001706:Biopsy; D006393:Hemangiopericytoma / Q000151:congenital* / Q000473:pathology / Q000601:surgery / Q000628:therapy* / Q000648:ultrastructure; D006801:Humans; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging; D008854:Microscopy, Electron; D018224:Myofibromatosis / Q000151:congenital* / Q000473:pathology / Q000601:surgery / Q000628:therapy*; D009365:Neoplasm Regression, Spontaneous