Preclinical comparison of bis-diketopiperazine-propane (dexrazoxane) and bis-diketopiperazine-ethane (antimet) on the adriamycin-cardiotoxic effect.
A cardiotoxic effect induced by adriamycin (by repeated i.v. administration to experimental rats in 7-day intervals of administration) begins to be manifested in the ECG record by prolongation of the S alpha T segment between days 14 and 20, on day 30 it is statistically significant. By means of this index, the known protective effect of dexrazoxane (the preparation Cardioxan) against adriamycin cardiotoxicity has been successfully confirmed in a four-week experiment. A comparative study (using the identical frequency of the dosing scheme and S alpha T segment as the decisive parameter) has revealed that antimet-as another original substance of the diketopiperazines group-also involves (though less significantly) protective effects against the toxic action of adriamycin.
Kvĕtina
J
J
Institute of Experimental Biopharmaceutics, Joint Laboratory of PRO.MED.CS, Prague, Czech Republic.
Grossmann
V
V
Svoboda
Z
Z
Safárová
M
M
D000284:Administration, Oral; D000818:Animals; D002317:Cardiovascular Agents / Q000008:administration & dosage / Q000494:pharmacology*; D004317:Doxorubicin; D004353:Drug Evaluation, Preclinical; D004569:Electroencephalography / Q000187:drug effects; D005260:Female; D006331:Heart Diseases / Q000139:chemically induced / Q000517:prevention & control*; D009215:Myometrium / Q000187:drug effects / Q000473:pathology; D010879:Piperazines / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D011929:Razoxane / Q000008:administration & dosage / Q000494:pharmacology*
D002317:Cardiovascular Agents; D010879:Piperazines; C106737:antimet; D011929:Razoxane; D004317:Doxorubicin