title: [Metabolism of angiotensin I in placenta tissue].
abstract: OBJECTIVE
  To explore whether placenta tissue could produce angiotensin I and the metabolism pathway of angiotensin I in placenta.
  
  
  METHODS
  Placenta tissues from 6 term pregnant women without any complication were cultured in vitro for 1 to 6 days, the angiotensin I concentrations in the medium were measured by radioimmunoassay in the first, second, fourth and sixth day. 5 to 500 mumol/l, captopril were added to the culture medium and the concentrations of angiotensin I were measured at the same times to observe the effect of angiotensin converting enzyme on the production of angiotensin I.
  
  
  RESULTS
  The concentration of angiotensin I in the placenta culture medium increased with the culture time. There were no significant differences in the concentrations, when captopril was added.
  
  
  CONCLUSIONS
  The placenta tissue can produce angiotensin I and its production does not depend on the angiotensin converting enzyme.
authors.affiliation: Peking Union Medical College Hospital, Beijing.
authors.forename: Q
authors.initials: Q
authors.lastname: Wang
authors.forename: N
authors.initials: N
authors.lastname: Shun
authors.forename: D
authors.initials: D
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000804:Angiotensin II / Q000378:metabolism*; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology; D002216:Captopril / Q000494:pharmacology; D002478:Cells, Cultured; D005260:Female; D006801:Humans; D010920:Placenta / Q000166:cytology / Q000378:metabolism*; D011247:Pregnancy
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D000804:Angiotensin II; D002216:Captopril