[Calcitonin, a proximal-tubular-acting diuretic: lithium clearance measurements in humans].
Lithium clearance was used to investigate the effect of calcitonin on renal sodium excretion. Two sequential renal function tests, calcitonin and placebo treated, were performed in 6 healthy students. Intravenous administration of 0.5 mg human calcitonin (hCT) (Cibacalcin, Ciba-Geigy, Basel, Switzerland) significantly raised fractional excretion of sodium (FENa), from 1.73% (0.97%) to 3.63% (0.89%) (p < 0.001), and lithium clearance (Cli), from 35.1 (5.4) to 53.9 (8.5) ml/ min x 1.73 m2 (p < 0.01). By using inulin and lithium clearance we calculated proximal (PFR), distal (DFR) and total excreted sodium (TAN). Our results clearly demonstrate that hCT has a proximal diuretic effect in humans and that a calcitonin induced proximal sodium loss is compensated by increased sodium reabsorption within 80 minutes after hCT application. Calcitonin increases the excretion of lithium and has a potential to be used in lithium intoxication.
Bachofen
M
M
Departement Innere Medizin, Kantonsspital Basel.
Bock
H
H
Beglinger
C
C
Fischer
J A
JA
Thiel
G
G
D000328:Adult; D002116:Calcitonin / Q000494:pharmacology*; D004232:Diuretics / Q000494:pharmacology*; D006801:Humans; D007444:Inulin / Q000652:urine; D007677:Kidney Function Tests; D007687:Kidney Tubules, Proximal / Q000187:drug effects; D008094:Lithium / Q000652:urine*; D008297:Male; D009318:Natriuresis / Q000187:drug effects*; D011446:Prospective Studies
D004232:Diuretics; D007444:Inulin; D002116:Calcitonin; D008094:Lithium