Non-adrenergic regulation of microcirculation evoked by antidromic stimulation of the saphenous nerve in the rat skin.
Electrical stimulation of the peripheral stump of the cut and perineurally capsaicin-pretreated saphenous nerve evokes antidromic vasodilatation preceded by a short vasoconstriction in the dorsal skin of the hindpaw in the rat. These microcirculatory changes were measured by laser-Doppler flowmetry. Blood flow increase induced by nerve stimulation was completely abolished by 1 microgram/kg resiniferatoxin (RTX), while the inicial blood flow decrease was significantly reduced or totally inhibited by subsequent treatments with an alpha adrenergic receptor antagonist (GYKI-12743) and a neuropeptide Y functional antagonist (alpha-trinositol) in response to 10 Hz and 3 HZ stimulations, respectively.
Pintér
E
E
Department of Pharmacology, University Medical School of Pécs, Hungary.
Helyes
Z
Z
Pethö
G
G
Szolcsányi
J
J
D018674:Adrenergic Antagonists / Q000494:pharmacology; D000818:Animals; D001775:Blood Circulation / Q000502:physiology*; D002211:Capsaicin / Q000494:pharmacology; D004558:Electric Stimulation; D005528:Foot; D007295:Inositol Phosphates / Q000494:pharmacology; D008833:Microcirculation / Q000502:physiology; D009424:Nervous System Physiological Phenomena; D009478:Neuropeptide Y / Q000037:antagonists & inhibitors; D051381:Rats; D017208:Rats, Wistar; D012039:Regional Blood Flow / Q000187:drug effects; D012867:Skin / Q000098:blood supply* / Q000294:innervation*; D013564:Sympathetic Nervous System / Q000502:physiology*; D014664:Vasodilation / Q000187:drug effects
D018674:Adrenergic Antagonists; D007295:Inositol Phosphates; D009478:Neuropeptide Y; D002211:Capsaicin; C059368:atrinositol