Studies on chemical modification of monensin. VI. Preparation of C-7 modified monensins via protected 7-oxomonensin and evaluation of their ion transport activity.
7-Carboxymethylmonensin (3), 7-aminomonensin (4), and 7-oxomonensin (5) were synthesized via protected 7-oxomonensin (2), which is expected to be a useful intermediate for the preparation of various monensin derivatives. intermediate for the preparation of various monensin derivatives. Compounds 3-5 exhibited smaller ion transport activity than monensin (1).
Nagatsu
A
A
Faculty of Pharmaceutical Sciences, Nagoya City University, Japan.
Tabunoki
Y
Y
Nagai
S
S
Ueda
T
T
Sakakibara
J
J
Hidaka
H
H
D002118:Calcium / Q000378:metabolism; D004910:Erythrocyte Membrane / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D017136:Ion Transport / Q000187:drug effects*; D007476:Ionophores / Q000737:chemistry* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008956:Models, Chemical; D008985:Monensin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D012964:Sodium / Q000378:metabolism
C107374:7-oxomonensin; D007476:Ionophores; D008985:Monensin; D012964:Sodium; D002118:Calcium