title: Clinical evaluation of pramipexole in advanced Parkinson's disease: results of a double-blind, placebo-controlled, parallel-group study.
abstract: We compared the efficacy, safety, an tolerability of pramipexole, an aminobenzathiazol-derived dopamine agonist with novel properties, with those of placebo in advanced PD patients with motor fluctuations under levodopa treatment. Pramipexole improved motor function of patients during "on" and "off" periods, decreased the time spent in "off" periods, reduced the severity of "off" periods, decreased disability and PD severity during "on" and "off" periods, as assessed by the Unified Parkinson Disease Rating Scale, and permitted a reduction in levodopa dosage. Adverse effects related to the central nervous system were similar to those reported with other dopamine agonists, and the gastrointestinal and cardiovascular tolerability of the compound was satisfactory.
authors.affiliation: National Parkinson Foundation, Phoenix, AZ, USA.
authors.forename: A
authors.initials: A
authors.lastname: Lieberman
authors.forename: A
authors.initials: A
authors.lastname: Ranhosky
authors.forename: D
authors.initials: D
authors.lastname: Korts
mesh_terms: D000978:Antiparkinson Agents / Q000627:therapeutic use*; D052160:Benzothiazoles; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000188:drug therapy*; D000077487:Pramipexole; D011379:Prognosis; D013844:Thiazoles / Q000627:therapeutic use*
chemical_list: D000978:Antiparkinson Agents; D052160:Benzothiazoles; D013844:Thiazoles; D000077487:Pramipexole