Protein kinase C in the postmortem brain of teenage suicide victims.
Increased serotonin2A (5-HT2A) receptors have been reported in the postmortem brain of suicide victims. To examine if this increase is associated with the dysregulation of postreceptor sites in the signaling cascade, we determined [3H]phorbol dibutyrate (PDBU) binding to protein kinase C (PKC) in postmortem brain samples (Brodmann's areas 8 and 9) obtained from teenage suicide victims and control subjects. [3H]PDBU binding to PKC was determined in membranal and cytosolic fractions. We observed that Bmax of [3H]PDBU binding sites was significantly decreased in both membranal and cytosolic fractions in brain samples from Brodmann's areas 8-9 compared to matched controls. These results thus suggest that PKC may play a role in the pathophysiology of suicidal behavior.
Pandey
G N
GN
Department of Psychiatry, University of Illinois at Chicago, 60612, USA.
Dwivedi
Y
Y
Pandey
S C
SC
Conley
R R
RR
Roberts
R C
RC
Tamminga
C A
CA
D000293:Adolescent; D001921:Brain / Q000201:enzymology* / Q000473:pathology*; D003600:Cytosol / Q000737:chemistry / Q000378:metabolism; D003863:Depression / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008565:Membrane Proteins / Q000737:chemistry / Q000378:metabolism; D015240:Phorbol 12,13-Dibutyrate / Q000378:metabolism / Q000494:pharmacology; D011485:Protein Binding / Q000502:physiology; D011493:Protein Kinase C / Q000032:analysis*; D013405:Suicide; D014316:Tritium
D008565:Membrane Proteins; D014316:Tritium; D015240:Phorbol 12,13-Dibutyrate; D011493:Protein Kinase C