Increased frequency of HLA-DR3 and complotype SCO1 in Mexican mestizo children with amoebic abscess of the liver.
The increase of HLA-DR3 and complotype SCO1 previously found in Mexican mestizo adults with E. histolytica amoebic abscess of the liver, was also found in Mexican mestizo children of either sex with the same disease, when compared to the healthy control population (adults and/or children) of the same ethnic and socioeconomic background. This HLA and complotype pattern was not found in Mexican Mestizo patients with amoebic rectocolitis. No linkage disequilibrium was found between these and the other MHC determinants tested in this survey. Thus, HLA-DR3 and SCO1 may constitute primary, independent risk factors, not for any kind of amoebic tissue invasion (i.e. amoebic rectocolitis), but specifically for amoebic liver abscess, irrespective of age or sex. The possibility of linkage disequilibrium with other factors (i.e. the TNF family) within or close to the MHC that were not tested in this study, is discussed. Children with amoebic liver abscess revealed a significant increase in HLA-DR5, and the absence of HLA-DR6 when compared to adults with amoebic liver abscess, suggesting that at least in this ethnic group these class II HLA traits may contribute to some of the peculiarities of pediatric amoebic liver abscess as opposed to the adult version of this disease. HLA-DR3, SCO1, but also HLA-DR5 and HLA-DR6 have all been associated with certain forms of immune-dysfunction, and may thus contribute to some of the clinical and immunological features of this parasitic disease.
Arellano
J
J
Division of Immunology, Subjefatura de Investigación Biomédica Centro Médico Nacional Siglo XXI, Instĩtuto Mexicano del Seguro Social, México.
Peŕez-Rodríguez
M
M
López-Osuna
M
M
Velázquez
J R
JR
Granados
J
J
Justiniani
N
N
Santos
J I
JI
Madrazo
A
A
Muñoz
L
L
Kretschmer
R
R
D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D004404:Dysentery, Amebic / Q000235:genetics / Q000276:immunology; D005006:Ethnicity / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D015803:HLA-DR3 Antigen / Q000235:genetics; D015805:HLA-DR5 Antigen / Q000235:genetics; D015808:HLA-DR6 Antigen / Q000235:genetics; D006801:Humans; D007198:Indians, North American / Q000235:genetics; D007223:Infant; D015810:Linkage Disequilibrium; D008101:Liver Abscess, Amebic / Q000235:genetics / Q000276:immunology*; D008297:Male; D008800:Mexico; D012307:Risk Factors; D044465:White People / Q000235:genetics
D015803:HLA-DR3 Antigen; D015805:HLA-DR5 Antigen; D015808:HLA-DR6 Antigen