Inhibitory effects of Chinese ant extract (CAE) on nephrotoxicity induced by ferric-nitrilotriacetate (Fe-NTA) in Wistar rats.
We observed the inhibitory effects of Chinese ant extract (CAE), a Chinese traditional medicine, on nephrotoxicity induced by Fe-NTA in Wistar rat. Strong positive staining with Schiff's reagent was found in the proximal tubules of the untreated control rats. In contrast, the positivity was very weak in CAE treated rats. The level of TBARS was also higher in the untreated control rats than in CAE treated rats. Meanwhile, the scavenging effect of CAE on hydroxyl radicals was analyzed by electron spin resonance (ESR) in vitro. The results indicate that CAE can efficiently prevent Fe-NTA induced nephrotoxicity through quenching free radicals mechanism.
Ma
Y
Y
Department of Pathology, Okayama University Medical School, Japan.
Wang
X
X
Zhao
Y
Y
Kawabata
T
T
Okada
S
S
D000818:Animals; D001000:Ants / Q000737:chemistry*; D002273:Carcinogens / Q000037:antagonists & inhibitors* / Q000633:toxicity; D005198:Fanconi Syndrome / Q000139:chemically induced; D005290:Ferric Compounds / Q000037:antagonists & inhibitors* / Q000633:toxicity; D016166:Free Radical Scavengers / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects* / Q000473:pathology; D008297:Male; D009571:Nitrilotriacetic Acid / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors / Q000633:toxicity; D051381:Rats; D017208:Rats, Wistar; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D014020:Tissue Extracts / Q000494:pharmacology*
D002273:Carcinogens; D005290:Ferric Compounds; D016166:Free Radical Scavengers; D017392:Thiobarbituric Acid Reactive Substances; D014020:Tissue Extracts; D009571:Nitrilotriacetic Acid; C020326:ferric nitrilotriacetate