title: [Local use of polymer-based cytostatic agents in surgical treatment of patients with laryngeal cancer].
abstract: To improve the outcomes of surgical or combined treatment of patients with laryngeal cancer stage III-IV in terms of preventing the recurrences and metastases, the authors placed biocompatible polymer material saturated with cytostatic in the operative wound in the end of the surgical intervention. The response assessed in 107 patients with laryngeal cancer treated with prospidin on polymer film (20 cases) versus 87 prospidin-untreated controls was more positive in the test group (5-year survival was higher).
authors.forename: A L
authors.initials: AL
authors.lastname: Klochikhin
authors.forename: G I
authors.initials: GI
authors.lastname: Markov
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D003131:Combined Modality Therapy; D004337:Drug Carriers; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000188:drug therapy* / Q000601:surgery*; D007825:Laryngectomy; D008297:Male; D008875:Middle Aged; D011108:Polymers; D011447:Prospidium / Q000008:administration & dosage*
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D011108:Polymers; D011447:Prospidium
vernacular_title: Mestnoe ispol'zovanie tsitostatikov na polimernoĭ osnove pri operatsiiakh u bolnykh rakom gortani.