Viscosity measurements for LEH suspended in different plasma expanders.
To investigate the possibility of hemodilution with oxygen carrying fluid, we measured the viscosity effects of LEH which was suspended in different weight percentage of plasma expanders for different shear rates. All of LEH/Plasma expander suspensions show shear thinning flow behavior, and the viscosity of those suspensions increase with increased the weight percentage of each expander in suspensions for a fixed shear rate. Compared the viscosity data to those of human blood at 40% of hematocrit, LEH/albumin suspensions contained with 4% to 8% of albumin are the most suitable, whereas LEH/dextran (Dex) suspensions contained with 6% Dex70c is the least favorable suspension media for LEH. In point of viscosity effects, hemodilution with LEH/albumin or LEH/0.9% oxypolygelatin (Gel) may be valuable for further testing their efficacy in animal model.
Chung
T W
TW
Department of Biomedical Engineering, Chung-Yuan Christian University, Taiwan, R.O.C.
Wang
J F
JF
D000818:Animals; D001802:Blood Substitutes / Q000737:chemistry*; D003911:Dextrans / Q000737:chemistry; D004912:Erythrocytes / Q000737:chemistry*; D005780:Gelatin / Q000737:chemistry; D006454:Hemoglobins / Q000737:chemistry*; D018056:Hemorheology; D006895:Hydroxyethyl Starch Derivatives / Q000737:chemistry; D008081:Liposomes / Q000737:chemistry*; D010952:Plasma Substitutes / Q000737:chemistry*; D012710:Serum Albumin, Bovine / Q000737:chemistry; D013535:Suspensions; D013552:Swine; D014783:Viscosity
D001802:Blood Substitutes; D003911:Dextrans; D006454:Hemoglobins; D006895:Hydroxyethyl Starch Derivatives; D008081:Liposomes; D010952:Plasma Substitutes; D013535:Suspensions; D012710:Serum Albumin, Bovine; D005780:Gelatin