Xanthines as a scaffold for molecular diversity.
Xanthines represent a new, versatile scaffold for combinatorial chemistry. A five-step solid-phase synthesis of xanthine derivatives is described which includes alkylations, a nucleophilic displacement reaction at a heterocycle and a ring closure reaction by condensation of a nitroso function with an activated methylene group. The selected reaction sequence allows the production of a highly diverse small-molecule combinatorial compound library.
Heizmann
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Department of Research (ZLF), University Hospital, Basel, Switzerland.
Eberle
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D000478:Alkylation; D002625:Chemistry, Organic / Q000379:methods; D002851:Chromatography, High Pressure Liquid; D015195:Drug Design; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D014970:Xanthines / Q000138:chemical synthesis* / Q000737:chemistry / Q000302:isolation & purification
D014970:Xanthines