[Helicobacter pylori associated gastrointestinal mucosal lesions: is there an increased risk during therapy with nonsteroidal antirheumatic agents?].
METHODS
Are there connections between Helicobacter pylori-induced and NSAID-induced gastrointestinal mucosal lesions leading to an increased risk? Are there any diagnostic or therapeutic consequences?


METHODS
Evaluation of H.P. infection, NSAID medication and mucosal lesions in 303 patients with rheumatic diseases.


RESULTS
The prevalence of H.P. infection was 67.7%. Positive H.P. antibodies were found in 96.2% of patients with mucosal lesions, confirmed by endoscopy. There was no statistically significant increase of mucosal lesions in patients with both H.P.-infection and NSAID therapy.


CONCLUSIONS
The main cause for gastrointestinal mucosal lesions is H.P. infection (> 90%). A general mucoprotective therapy in patients with H.P. infection and NSAID therapy cannot be supported. It may be supposed that a part of mucosal lesions connected to NSAID-therapy in recent decades probably was the consequence of H.P. infections. Eradication of H.P. might be of higher importance in the future.
Pöllmann
G
G
Rehabilitationszentrum für rheumatische, Erkrankungen und Herzkreislauferkrankungen der PVAarb, Saalfelden, Osterreich.
Kullich
W
W
Klein
G
G
D000328:Adult; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects* / Q000473:pathology; D005756:Gastritis / Q000150:complications* / Q000473:pathology; D016481:Helicobacter Infections / Q000150:complications* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010437:Peptic Ulcer / Q000139:chemically induced / Q000473:pathology; D012307:Risk Factors
D000894:Anti-Inflammatory Agents, Non-Steroidal
Helicobacter-pylori-assoziierte gastrointestinale Schleimhautläsionen: Besteht ein erhöhtes Risiko unter Therapie mit nichtsteroidalen Antirheumatika?