Helicobacter pylori infection and gastric emptying of indigestible solids in patients with dysmotility-like dyspepsia.
BACKGROUND
The role of Helicobacter pylori and gastric motility in dysmotility-like dyspepsia is unclear. The aim of this study was to determine whether delayed gastric emptying of indigestible solids and H. pylori infection are associated with dysmotility-like dyspepsia.


METHODS
Thirty-two healthy volunteers and 72 patients fulfilling the criteria of dysmotility-like dyspepsia received a gastric emptying test using radiopaque markers, and the H. pylori status was determined by histology.


RESULTS
Twenty-seven percent of volunteers were H. pylori-positive, compared with 32% in the dyspeptic groups (P = NS). Gastric emptying was significantly slower in dyspeptic patients than controls and in H. pylori-positive patients than H. pylori-negative patients. Subjects with gastroparesis have a higher chance of developing dysmotility-like dyspepsia (odds ratio (OR), 2.5) than subjects with normal gastric emptying. Subjects with H. pylori and gastroparesis have an increased likelihood of developing dysmotility-like dyspepsia (OR, 4.3) than if either factor were present alone.


CONCLUSIONS
Our data suggest that gastroparesis alone and gastroparesis and H. pylori infection are associated with dysmotility-like dyspepsia.
Fock
K M
KM
Dept. of Medicine, Toa Payoh Hospital, Singapore.
Khoo
T K
TK
Chia
K S
KS
Sim
C S
CS
D000328:Adult; D016022:Case-Control Studies; D004415:Dyspepsia / Q000382:microbiology* / Q000503:physiopathology*; D005260:Female; D005502:Food; D005746:Gastric Emptying / Q000502:physiology*; D005769:Gastrointestinal Motility / Q000502:physiology; D018589:Gastroparesis / Q000382:microbiology* / Q000503:physiopathology*; D016481:Helicobacter Infections / Q000503:physiopathology*; D016480:Helicobacter pylori; D006801:Humans; D008297:Male