title: Bone marrow transplantation from unrelated volunteer donors. An overview.
abstract: Marrow transplantation from a phenotypically identical unrelated donor has become a feasible and curative form of treatment for patients with several malignant and nonmalignant disorders who lack an HLA-matched sibling donor. Given the rapid growth of registries of HLA-typed volunteers-including nearly 3,000,000 people-it is now possible to identify a suitable unrelated marrow donor for up to 50% of patients. In this review the recent acquisitions regarding the structure of HLA complex, the new molecular typing technologies and clinical results obtained with unrelated marrow transplants, will be considered.
authors.affiliation: Department of Pediatrics, University of Turin, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Busca
authors.forename: A
authors.initials: A
authors.lastname: Amoroso
authors.forename: R
authors.initials: R
authors.lastname: Miniero
mesh_terms: D016026:Bone Marrow Transplantation / Q000276:immunology*; D006801:Humans; D010641:Phenotype; D014019:Tissue Donors; D016896:Treatment Outcome