title: [Gamma-linolenic-acid-rich borage seed oil capsules in children with atopic dermatitis. A placebo-controlled double-blind study].
abstract: We investigated the effect of gamma-linolenic-acid from borage seed on atopic dermatitis of children. In a placebo-controlled, double-blind manner we studied 24 patients, 3-17 years old. Every patient received 360 mg of gamma-linolenic acid daily, independent from sex and age; the same amount of corn seed-oil served as placebo. After 10 to 14 weeks of treatment there was no improvement of the eczema in the verum phase compared to placebo. Both groups showed improvement while taking placebo. This result could be seen in the objective investigations (Costa-Score, 3 times per treatment period) as well as in the daily patients documentation. The patients whose eczema has improved under borage seed-oil (n = 10) had no special characteristics, so that we could not identify any responder-type.
authors.affiliation: Kinderklinik, Kreiskrankenhaus Lörrach.
authors.forename: S
authors.initials: S
authors.lastname: Borrek
authors.forename: A
authors.initials: A
authors.lastname: Hildebrandt
authors.forename: J
authors.initials: J
authors.lastname: Forster
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003314:Corn Oil / Q000008:administration & dosage; D003876:Dermatitis, Atopic / Q000188:drug therapy*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D010919:Placebos; D010938:Plant Oils / Q000627:therapeutic use*; D017965:gamma-Linolenic Acid / Q000627:therapeutic use*
chemical_list: D010919:Placebos; D010938:Plant Oils; D017965:gamma-Linolenic Acid; D003314:Corn Oil
vernacular_title: Gammalinolensäure-reiche Borretschsamenöl-Kapseln bei Kindern mit Atopischer Dermatitis. Eine placebo-kontrollierte Doppelblind-Studie.