Cytogenetic support for early malignant change in a diffuse neurofibroma not associated with neurofibromatosis.
A 62-year-old woman presented with a solitary diffuse neurofibroma; a second recurrence showed features indicative of malignancy, but insufficient for a certain histologic diagnosis. Cytogenetic analysis revealed abnormalities previously described in malignant peripheral nerve sheath tumors and not in their benign counterparts, thus supporting the histologic suspicion of emerging malignancy.
Molenaar
W M
WM
Department of Pathology, University Hospital, Groningen, The Netherlands.
Dijkhuizen
T
T
van Echten
J
J
Hoekstra
H J
HJ
van den Berg
E
E
D002869:Chromosome Aberrations; D005260:Female; D006801:Humans; D007621:Karyotyping; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009455:Neurofibroma / Q000235:genetics* / Q000473:pathology; D012303:Ring Chromosomes; D012983:Soft Tissue Neoplasms / Q000235:genetics* / Q000473:pathology; D014178:Translocation, Genetic