Preimplant atrial defibrillation testing with a temporary catheter in sheep.
Prior to implantation of an atrial defibrillator, its effectiveness should be tested in each patient. A new catheter design for temporary use with electrodes for atrial defibrillation, electrogram sensing, and pacing was tested in this study. Atrial defibrillation thresholds defined using this temporary catheter were compared to the ones defined by catheters intended for chronic use with an implantable atrial defibrillator. Atrial defibrillation threshold was determined in six sheep using both types of catheters. Each animal was subjected to studies on 2 consecutive days. On the first day, shocks were applied between two of the temporary catheters. On the following day, permanent leads were inserted and atrial defibrillation threshold was redetermined. In both cases, defibrillation electrodes were positioned in the same heart location with one electrode in the distal coronary sinus and the second electrode in the right atrium. Atrial defibrillation threshold was obtained using 10 V increments or decrements to determine the lowest shock intensity needed to defibrillate the atria. Threshold was defined as the shock intensity at which 20 shock percent success was at or between 15% and 85%. Statistical analysis showed no significant difference (P < 0.05) between atrial defibrillation threshold energy (0.53 J vs 0.55 J), voltage (122 V vs 120 V) or current (2.2 A vs 2.6 A) measured with the temporary catheters and the permanent leads, respectively. These data indicate that temporary catheters can be used for efficacy testing prior to implant of an atrial defibrillator, and that they predict atrial defibrillation threshold adequately for chronic leads.
Elabbady
T Z
TZ
Purdue University, West Lafayette, Indiana, USA. telabbad@physio-control.com
Tacker
W A
WA
Geddes
L A
LA
Ayers
G M
GM
D000818:Animals; D001281:Atrial Fibrillation / Q000628:therapy*; D018780:Body Surface Potential Mapping / Q000295:instrumentation; D002304:Cardiac Pacing, Artificial; D002404:Catheterization / Q000295:instrumentation*; D003331:Coronary Vessels; D017147:Defibrillators, Implantable; D017097:Electric Impedance; D004558:Electric Stimulation; D004562:Electrocardiography; D004567:Electrodes, Implanted; D004867:Equipment Design; D005260:Female; D006325:Heart Atria; D008297:Male; D012756:Sheep