title: Antihypertensive drugs in the stroke-prone spontaneously hypertensive rat.
abstract: The stroke-prone spontaneously hypertensive rat (SHR-SP) is an experimental model that has been widely used to investigate the potential preventive effects vs stroke and mortality of numerous antihypertensive agents. Among the latter, angiotensin I-converting enzyme inhibitors, angiotensin II AT1-receptor blockers and calcium antagonists have proven to be very effective. The mechanisms involved in their beneficial effects include limitation of the age-related alterations of large cerebral arteries' functional parameters, prevention of fibrinoid necrosis formation in cerebral arterioles and, to a lesser extent, limitation of the blood pressure rise.
authors.affiliation: Département de Pharmacologie, Faculté de Médecine Paris-Sud, Le Kremlin-Bicêtre, France.
authors.forename: C
authors.initials: C
authors.lastname: Richer
authors.forename: E
authors.initials: E
authors.lastname: Vacher
authors.forename: P
authors.initials: P
authors.lastname: Fornes
authors.forename: J F
authors.initials: JF
authors.lastname: Giudicelli
mesh_terms: D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects / Q000473:pathology; D002536:Cerebral Arteries / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology; D002561:Cerebrovascular Disorders / Q000517:prevention & control*; D004195:Disease Models, Animal; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D051381:Rats; D011918:Rats, Inbred SHR; D014661:Vasoconstriction / Q000187:drug effects
chemical_list: D000959:Antihypertensive Agents