title: A randomized controlled trial of piroxicam in the management of acute ankle sprain in Australian Regular Army recruits. The Kapooka Ankle Sprain Study.
abstract: Three hundred sixty-four Australian Regular Army recruits with acute ankle sprains sustained during training were randomized to treatment with either piroxicam or placebo. Compared with the placebo group, subjects treated with piroxicam had less pain, were able to resume training more rapidly, were treated at lower cost, and were found to have increased exercise endurance on resumption of activity. Nausea was the only side effect reported significantly more often in the treatment group than in the placebo group (6.8% versus 0.3%). Interestingly, subjects treated with piroxicam showed some evidence of local abnormalities such as instability and reduced range of movement. We conclude that nonsteroidal antiinflammatory agents should form an integral part of the treatment of acute ankle sprains.
authors.affiliation: 1st Recruit Training Battalion, Kapooka, New South Wales, Australia.
authors.forename: M A
authors.initials: MA
authors.lastname: Slatyer
authors.forename: M J
authors.initials: MJ
authors.lastname: Hensley
authors.forename: R
authors.initials: R
authors.lastname: Lopert
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D016512:Ankle Injuries / Q000188:drug therapy* / Q000191:economics / Q000534:rehabilitation / Q000628:therapy; D000843:Ankle Joint / Q000187:drug effects; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects / Q000191:economics / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D005500:Follow-Up Studies; D017048:Health Care Costs; D006801:Humans; D007593:Joint Instability / Q000139:chemically induced; D008297:Male; D008889:Military Personnel / Q000193:education; D009325:Nausea / Q000139:chemically induced; D009517:New South Wales; D010146:Pain / Q000188:drug therapy; D010807:Physical Endurance; D010894:Piroxicam / Q000009:adverse effects / Q000191:economics / Q000627:therapeutic use*; D010919:Placebos; D016059:Range of Motion, Articular / Q000187:drug effects; D013180:Sprains and Strains / Q000188:drug therapy* / Q000191:economics / Q000534:rehabilitation / Q000628:therapy; D013997:Time Factors
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D010919:Placebos; D010894:Piroxicam