Propylthiouracil-induced cutaneous vasculitis.
Cutaneous reactions to propylthiouracil and methimazole occur in 3%-5% of adults. Generalized maculopapular and papular purpuric eruptions are perhaps the most common thionamide-induced reactions. We report 3 patients who developed cutaneous vasculitis which is a rare and serious side-effect during antithyroid drug therapy. The observation of cutaneous vasculitis during administration of propylthiouracil suggested that clinical awareness of this complication should be of considerable importance.
Yarman
S
S
Department of Internal Medicine, Istanbul Faculty of Medicine, University of Istanbul, Capa, Turkey.
Sandalci
O
O
Tanakol
R
R
Azizlerli
H
H
Oguz
H
H
Alagöl
F
F
D000328:Adult; D013956:Antithyroid Agents / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006111:Graves Disease / Q000188:drug therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D011441:Propylthiouracil / Q000009:adverse effects* / Q000627:therapeutic use; D012871:Skin Diseases / Q000139:chemically induced* / Q000175:diagnosis / Q000473:pathology; D018366:Vasculitis, Leukocytoclastic, Cutaneous / Q000139:chemically induced* / Q000175:diagnosis / Q000473:pathology
D013956:Antithyroid Agents; D011441:Propylthiouracil