Hyperamylasemia due to macroamylasemia in adult gluten enteropathy.
We report hyperamylasemia due to macroamylasemia in a 33-year-old-woman with gluten enteropathy. Macroamylasemia was demonstrated by precipitation of 97% of amylase activity with PEG 6000. It was associated with increased serum IgA, with elevated values of specific IgA antibodies against alpha-gliadin and with a high titre of IgA anti-endomysium antibodies. Macroamylasemia disappeared after 2 months of a strict gluten-free diet. These data suggest that the increased IgA concentration in adult gluten enteropathy led to increased macroamylase formation.
Bonetti
G
G
Department of Clinical Biochemistry, University of Pavia, Policlinico San Matteo, Italy.
Serricchio
G
G
Giudici
A
A
Bettonagli
M
M
Vadacca
G B
GB
Bruno
R
R
Coslovich
E
E
Moratti
R
R
D000328:Adult; D000681:Amylases / Q000097:blood* / Q000652:urine; D002446:Celiac Disease / Q000097:blood* / Q000201:enzymology* / Q000276:immunology; D005260:Female; D005903:Gliadin / Q000276:immunology; D006801:Humans; D046911:Macromolecular Substances
D046911:Macromolecular Substances; D005903:Gliadin; D000681:Amylases; C001663:macroamylase