Cytogenetic damage in marrow cells of mice after injections of yttrium-90-labeled monoclonal antibody.
Chromosome aberrations, micronuclei and sister-chromatid exchanges were quantified in marrow cells of athymic nude and B6C3F1 mice at various times up to 14 days after injection of 90Y-labeled monoclonal antibody CO17-1A. Aberrations, predominantly of the chromatid type, were sharply elevated at 24 h post-injection then declined in a curvilinear fashion over the 14 days. Micronucleus numbers among polychromatic erythrocytes peaked 3-4 days after treatment, then declined exponentially but remained at higher than expected levels. Sister-chromatid exchanges were roughly double the control rate with no apparent relation to post-treatment time.
McFee
A F
AF
Medical Sciences Division, Oak Ridge Institute for Science and Education, TN 37831-0117, USA.
Robertson
S D
SD
Washburn
L C
LC
D000818:Animals; D000911:Antibodies, Monoclonal / Q000009:adverse effects* / Q000276:immunology; D000951:Antigens, Neoplasm / Q000276:immunology; D002869:Chromosome Aberrations; D051379:Mice; D008819:Mice, Nude; D015021:Yttrium Radioisotopes / Q000009:adverse effects*
D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm; D015021:Yttrium Radioisotopes; C050928:carcinoma-associated antigen 17-1A