title: Acute leukaemia during tamoxifen therapy.
abstract: Tamoxifen treatment is a proven therapy for breast cancer that produces a survival advantage when used as an adjuvant, and reduces the incidence of recurrences and controlateral tumor evolution. Although this therapy has a very low toxicity profile, an increase in secondary cancers has been reported. Tamoxifen is suggested to be carcinogenic both through direct genotoxic and epigenetic mechanisms. It is activated by cytochrome P450 to form reactive metabolites that bind covalently to DNA to create adducts. We report two cases that developed acute myeloid leukaemia (AML) during tamoxifen therapy for breast cancer.
authors.affiliation: Hacettepe University Institute of Oncology, Ankara, Turkey.
authors.forename: S
authors.initials: S
authors.lastname: Yalçin
authors.forename: I
authors.initials: I
authors.lastname: Güllü
authors.forename: H
authors.initials: H
authors.lastname: Demiroğlu
authors.forename: G
authors.initials: G
authors.lastname: Tekuzman
mesh_terms: D018931:Antineoplastic Agents, Hormonal / Q000009:adverse effects* / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000139:chemically induced*; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000139:chemically induced*; D013629:Tamoxifen / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D018931:Antineoplastic Agents, Hormonal; D013629:Tamoxifen