Bone status after long-term anticonvulsant therapy in epileptic patients: evaluation using quantitative ultrasound of calcaneus and phalanges.
The bone status of 25 epileptic female patients on long-term (mean 19 y) anticonvulsant therapy was investigated using quantitative ultrasound of the calcaneus (Lunar Achilles) and phalanges (Igea DBM Sonic 1200). Comparisons were made with a control group of 43 normal healthy women. Radiogrammetric measurements of the second metacarpal bone were also made in the epileptic patients. While all of the ultrasonic parameters were reduced in the epileptic group, differences only achieved statistical significance for speed of sound (SOS) at the phalanges. Phalangeal SOS correlated significantly with cortical thickness of the second metacarpal bone (r = 0.44, p < 0.05). The data suggest that long-term anticonvulsant therapy is associated with significant cortical bone loss. Quantitative ultrasound may have a role in monitoring bone loss in epileptic patients and in guiding suitable preventive therapy.
Pluskiewicz
W
W
Department of Internal and Allergic Diseases, Silesian School of Medicine, Katowice, Poland.
Nowakowska
J
J
D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects* / Q000627:therapeutic use; D002111:Calcaneus / Q000000981:diagnostic imaging; D002220:Carbamazepine / Q000009:adverse effects / Q000627:therapeutic use; D016022:Case-Control Studies; D004359:Drug Therapy, Combination; D004827:Epilepsy / Q000000981:diagnostic imaging / Q000188:drug therapy*; D005260:Female; D005385:Fingers / Q000000981:diagnostic imaging; D006801:Humans; D010018:Osteomalacia / Q000139:chemically induced* / Q000000981:diagnostic imaging*; D010672:Phenytoin / Q000009:adverse effects / Q000627:therapeutic use; D013997:Time Factors; D014463:Ultrasonography
D000927:Anticonvulsants; D002220:Carbamazepine; D010672:Phenytoin