Serum erythrocyte and leukocyte adenosine deaminase activities in patients with vivax malaria in Turkey.
Adenosine deaminase (ADA) activities in serum samples, erythrocytes, leukocytes and plasma hemoglobin concentrations were investigated in 50 patients with vivax malaria and compared with control group. ADA activity was determined by Bertholet reaction. Student's t-test and correlation analyses methods were used for statistical analyses. Serum ADA activity in patients with vivax malaria 49.20 +/- 29.02 IU/I, in control 21.15 +/- 8.04 IU/I (p = 0.005), erythrocyte ADA activity in patients 2.91 +/- 1.23 U/gr Hb, in control 1.65 +/- 0.59 U/gr (p = 0.001), leukocyte specific ADA activity in patients 26.23 +/- 20.21 U/mg protein, in control 25.84 +/- 9.19 U/gr Hb were determined (P > 0.05). Plasma hemoglobin concentration in patients 29.25 +/- 28.10 ml/dl, in control 9.80 +/- 13.14 mg/dl were also determined. There is no significant correlation among mentioned parameters. Erythrocyte purine salvage pathway is accelerated by Plasmodium to provide preformed purine source which can not be synthesized by Plasmodium to provide preformed purine source which can correlation between plasma hemoglobin concentration and serum ADA activity suggests that increased serum ADA activity may develop secondarily to the disease independently from the hemolyses. No higher ADA activity level than expected value of leukocytes may reflect immunosuppression of leukocytes.
Ozcan
E
E
Department of Biochemistry, Medical Faculty, Harran University, Sanliurfa, Turkey.
Abdurrahim
K
K
Adnan
S
S
Senel
A
A
Necmeddin
A
A
D000243:Adenosine Deaminase / Q000097:blood*; D000293:Adolescent; D000328:Adult; D004912:Erythrocytes / Q000201:enzymology*; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007962:Leukocytes / Q000201:enzymology*; D016780:Malaria, Vivax / Q000097:blood* / Q000201:enzymology; D012016:Reference Values; D014421:Turkey
D006454:Hemoglobins; D000243:Adenosine Deaminase