Commutability between stabilized materials and fresh human serum to improve laboratory performance.
With the recent advances in laboratory technology, many quality-related problems have been improved. However, the issue of commutability, a factor that greatly affects daily decisions concerning patient status, still remains to be solved. This paper determines the commutability between 27 stabilized materials (controls and calibrators) and clinical specimens for five serum quantities, using carrier-bound reagent chemistry and conventional wet methods. Our aim was to pinpoint the specific problems related to non-commutable calibrators and controls in our setting, and minimize their effect in daily practice. We found major difficulties in selecting appropriate accuracy controls in carrier-bound reagent techniques, and in finding materials commutable for several analytes simultaneously. Several suggestions for reducing problems related to non-commutability, such as procedures for assigning values to multicalibrators, are proposed. We explain the apparent incongruencies observed in daily quality surveillance, when data from different control materials (internal quality control and external quality assessment) are evaluated. The conclusions emphasize the need for a combined effort (manufacturers, organizers of external quality assessment schemes and individual laboratories) to find the cause of, and eliminate, the negative repercussions on laboratory performance produced by non-commutability.
Ricós
C
C
Servicio de Bioquñimica, Hospital General Vall d'Hebron, Barcelona, Spain. parera@mailhost.nauta.es
Juvany
R
R
Alvarez
V
V
Jiménez
C V
CV
Perich
C
C
Minchinela
J
J
Hernández
A
A
Simón
M
M
D001774:Blood Chemical Analysis / Q000379:methods* / Q000592:standards; D001786:Blood Glucose / Q000032:analysis; D002784:Cholesterol / Q000097:blood; D003404:Creatinine / Q000097:blood; D004355:Drug Stability; D005069:Evaluation Studies as Topic; D006801:Humans; D007202:Indicators and Reagents; D011786:Quality Control; D012015:Reference Standards; D014508:Urea / Q000097:blood; D014527:Uric Acid / Q000097:blood
D001786:Blood Glucose; D007202:Indicators and Reagents; D014527:Uric Acid; D014508:Urea; D002784:Cholesterol; D003404:Creatinine