title: Association of rheumatoid arthritis with an amino acid allelic variation of the T cell receptor.
abstract: OBJECTIVE
  To investigate allelic variations of T cell receptor residues for a contribution to rheumatoid arthritis (RA) susceptibility.
  
  
  METHODS
  We conducted an RA case-control study involving 1,579 northwest Europeans: 766 patients with erosive and rheumatoid factor-positive disease and 813 control subjects. Productive changes of segments TCRAV6S1, TCRAV7S1, TCRAV8S1, TCRAV10S2, and TCRBV6S1, TCRBV6S7 were investigated by single-strand conformation polymorphisms. The TCRAV8S1 association was confirmed by restriction fragment length polymorphism.
  
  
  RESULTS
  In the systematic study (77 patients and 119 controls), an increase in 1 TCRAV8S1 genotype was found in the RA patients (P = 0.0004). This finding was replicated in 2 further populations, one from France (212 patients and 254 controls) and the other from Britain (477 patients and 440 controls), with a similar odds ratio (OR), which allowed pooling of the data and confirmation of the association (OR 1.3 [95% confidence interval 1.1-1.7], P = 0.008).
  
  
  CONCLUSIONS
  These findings show evidence that TCRA is an RA susceptibility locus.
authors.affiliation: INSERM U358 and Université Paris 7-Hôpital Lariboisière, France.
authors.forename: F
authors.initials: F
authors.lastname: Cornélis
authors.forename: L
authors.initials: L
authors.lastname: Hardwick
authors.forename: R M
authors.initials: RM
authors.lastname: Flipo
authors.forename: M
authors.initials: M
authors.lastname: Martinez
authors.forename: S
authors.initials: S
authors.lastname: Lasbleiz
authors.forename: J F
authors.initials: JF
authors.lastname: Prud'homme
authors.forename: T H
authors.initials: TH
authors.lastname: Tran
authors.forename: S
authors.initials: S
authors.lastname: Walsh
authors.forename: A
authors.initials: A
authors.lastname: Delaye
authors.forename: A
authors.initials: A
authors.lastname: Nicod
authors.forename: M N
authors.initials: MN
authors.lastname: Loste
authors.forename: V
authors.initials: V
authors.lastname: Lepage
authors.forename: K
authors.initials: K
authors.lastname: Gibson
authors.forename: K
authors.initials: K
authors.lastname: Pile
authors.forename: S
authors.initials: S
authors.lastname: Djoulah
authors.forename: P M
authors.initials: PM
authors.lastname: Danzé
authors.forename: F
authors.initials: F
authors.lastname: Lioté
authors.forename: D
authors.initials: D
authors.lastname: Charron
authors.forename: J
authors.initials: J
authors.lastname: Weissenbach
authors.forename: D
authors.initials: D
authors.lastname: Kuntz
authors.forename: T
authors.initials: T
authors.lastname: Bardin
authors.forename: B P
authors.initials: BP
authors.lastname: Wordsworth
mesh_terms: D000483:Alleles; D001172:Arthritis, Rheumatoid / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D018807:Polymorphism, Single-Stranded Conformational; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000235:genetics*
chemical_list: D016693:Receptors, Antigen, T-Cell, alpha-beta