title: omega-Conotoxin GVIA and desipramine insensitive norepinephrine efflux from cardiac sympathetic nerve terminal.
abstract: Using dialysis technique, prominent accumulation of norepinephrine (NE) in the myocardial interstitial space was observed under local administration of a monoamine oxidase inhibitor (pargyline, 10 mM), and a vesicle uptake inhibitor (reserpine, 10 microM). Accumulation of NE in the myocardial interstitial space was associated with a reduction of dihydroxyphenylglycol levels. Pretreatment with omega-conotoxin GVIA (10 microM) or desipramine (10 microM) did not suppress this response. A brisk increase in dialysate NE levels might occur as a consequence of exocytotic or neurotransporter insensitive efflux of NE.
authors.affiliation: Department of Cardiac Physiology, National Cardiovascular Center Research Institute, Suita, Osaka, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Yamazaki
authors.forename: T
authors.initials: T
authors.lastname: Kawada
authors.forename: T
authors.initials: T
authors.lastname: Akiyama
authors.forename: H
authors.initials: H
authors.lastname: Kitagawa
authors.forename: Y
authors.initials: Y
authors.lastname: Takauchi
authors.forename: N
authors.initials: N
authors.lastname: Yahagi
authors.forename: K
authors.initials: K
authors.lastname: Sunagawa
mesh_terms: D000320:Adrenergic Fibers / Q000187:drug effects / Q000378:metabolism; D018759:Adrenergic Uptake Inhibitors / Q000494:pharmacology*; D000818:Animals; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D002415:Cats; D003891:Desipramine / Q000494:pharmacology*; D005260:Female; D006321:Heart / Q000294:innervation*; D008297:Male; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology; D009638:Norepinephrine / Q000378:metabolism*; D010293:Pargyline / Q000494:pharmacology; D010455:Peptides / Q000494:pharmacology*; D017729:Presynaptic Terminals / Q000187:drug effects / Q000378:metabolism; D012110:Reserpine / Q000494:pharmacology; D020866:omega-Conotoxin GVIA
chemical_list: D018759:Adrenergic Uptake Inhibitors; D002121:Calcium Channel Blockers; D008996:Monoamine Oxidase Inhibitors; D010455:Peptides; D012110:Reserpine; D020866:omega-Conotoxin GVIA; D010293:Pargyline; D003891:Desipramine; D009638:Norepinephrine