title: [Disorders of anticoagulation and fibrinolysis in monoclonal gammopathies--another mechanism of paraprotein interference with hemostasis].
abstract: We have investigated the possible interaction of paraprotein (pp) with anticoagulation mechanisms and fibrinolysis. Eighty four patients with monoclonal gammapathy (MG) were included to the study, 59 of them with multiple myeloma (MM). In 48.8% cases some defect was found. Decreased levels of antithrombin III (AT III) was observed in 13.3%, protein C (PC) in 18.3% and protein S (PS) in 13.5% of patients. Distribution between the free and the bound PS fraction remained normal. The most frequent abnormality found was the reduction of plasminogen (PLG) activity, which was observed in 35.1% and elevated levels of plasminogen activator inhibitor, detected in 42.3% of cases, respectively. Decreased plasminogen activator activity was observed in only one patient. The relationship between isotype and concentration of paraprotein and frequency of factor levels abnormalities was not found. The incidence of arterial and/or venous thrombosis was higher in patients with laboratory defect in comparison with the unaffected, however, the difference was not statistically significant. In contrast, the incidence of hemorrhagic complications was significantly lower in these patients (p < 0.01), although in most of them simultaneous defect of plasmatic coagulation and/or platelet functions was detected. We suggest, the interaction with both hemostatic and anticoagulation systems could result to "elimination" of inauspicious effect of pp on hemostasis. The impairment of anticoagulation systems and fibrinolysis is another type of paraprotein interference with hemostasis. It is also considered to be another pathogenetic mechanism of secondary deficiency of AT III, PC, PS and PLG.
authors.affiliation: I. Interní Klinika 1. lékarské fakulty Univerzity Karlovy, Praha, Czech Republic.
authors.forename: I
authors.initials: I
authors.lastname: Spicka
authors.forename: P
authors.initials: P
authors.lastname: Cieslar
authors.forename: Z
authors.initials: Z
authors.lastname: Hrkal
authors.forename: H
authors.initials: H
authors.lastname: Fortová
authors.forename: E
authors.initials: E
authors.lastname: Simonianová
authors.forename: R
authors.initials: R
authors.lastname: Zounar
authors.forename: P
authors.initials: P
authors.lastname: Klener
mesh_terms: D000328:Adult; D000368:Aged; D000990:Antithrombin III / Q000032:analysis; D001777:Blood Coagulation; D005260:Female; D005342:Fibrinolysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D010265:Paraproteinemias / Q000097:blood*; D011486:Protein C / Q000032:analysis; D017293:Protein S / Q000032:analysis
chemical_list: D011486:Protein C; D017293:Protein S; D000990:Antithrombin III
vernacular_title: Poruchy antikoagulacních systémů a fibrinolýzy u monoklonálních gamapatií--dalsí mechanismus interference paraproteinu s hemostázou.