The effects of hypertonic saline in healthy and diseased animals.
In this review, the pharmacological effects of administering hypertonic solutions to both healthy animals and during experimentally induced diseases are considered with a view to understanding the mechanisms behind the possible clinical efficacy of such treatment. The review focuses successively on haemorrhagic shock, endotoxic shock and hypokalaemic metabolic alkalosis. How hypertonic saline solutions affect oxygen transport by haemoglobin is also considered.
Cambier
C
C
Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Liège, Belgium.
Ratz
V
V
Rollin
F
F
Frans
A
A
Clerbaux
T
T
Gustin
P
P
D000471:Alkalosis / Q000628:therapy / Q000662:veterinary*; D000820:Animal Diseases / Q000503:physiopathology / Q000628:therapy*; D000818:Animals; D002320:Cardiovascular Physiological Phenomena; D006454:Hemoglobins / Q000502:physiology; D010101:Oxygen Consumption / Q000502:physiology; D012462:Saline Solution, Hypertonic / Q000627:therapeutic use*; D012771:Shock, Hemorrhagic / Q000628:therapy / Q000662:veterinary*; D012772:Shock, Septic / Q000628:therapy / Q000662:veterinary*; D014553:Urinary Tract Physiological Phenomena
D006454:Hemoglobins; D012462:Saline Solution, Hypertonic