Antibiotic exposure and its relationship to postantibiotic effect and bactericidal activity: constant versus exponentially decreasing tobramycin concentrations against Pseudomonas aeruginosa.
In vitro postantibiotic effects (PAEs) exhibited by a standard strain of Pseudomonas aeruginosa following exposure to tobramycin at constant concentrations were compared to those at exponentially decreasing concentrations. Exposure to a constant concentration showed more extensive bacterial killing and resulted in longer PAEs at comparable areas under the concentration-time curves above the MIC. This phenomenon suggests a significant contribution of pharmacokinetics to antimicrobial pharmacodynamics.
Li
R C
RC
Department of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Shatin. ronli@cuhk.edu.hk
Zhu
Z Y
ZY
Lee
S W
SW
Raymond
K
K
Ling
J M
JM
Cheng
A F
AF
D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000494:pharmacology*; D002452:Cell Count; D008826:Microbial Sensitivity Tests; D011550:Pseudomonas aeruginosa / Q000187:drug effects*; D013997:Time Factors; D014031:Tobramycin / Q000008:administration & dosage / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D014031:Tobramycin