title: T-cell receptor in Sjögren's syndrome.
abstract: Studies on the TCR repertoire of T cells in several inflamed lesions of SS patients have shown that there exist no unique TCR V family genes, although TCR V gene usage is relatively restricted. Analysis of the clonality of infiltrating T cells shows that some T cells expand clonally in lesions, suggesting that these cells were induced by antigen-driven rather than superantigen-driven stimulation. The restricted usage of the TCRJ beta, V alpha and J alpha genes also supports the notion that all expanded T cells do not accumulate due to superantigen. Junctional sequence analysis has revealed some conserved amino acid sequence motifs in the TCR CDR3 region, which is the antigen-binding site on T cells. These observations strongly suggest that pathogenic T cells in lesions recognize limited epitopes on autoantigens in the context of HLA. These findings are similar to TCR on T cells in rheumatoid synovium, as described elsewhere [51]. Intriguingly, T cells in lacrimal and labial salivary glands recognize common epitopes, but T cells in the kidney react with different autoantigens from those in minor salivary glands. In the future, the peptides recognized by pathogenic autoreactive T cells should be clarified to elucidate the mechanism for the progression of SS. Moreover, we predict that a vaccination with analogue peptides, to induce autoreactive T cells to anergy, might provide a new strategy for the specific treatment of SS.
authors.affiliation: Division of Rheumatology and Molecular Immunology, St Marianna University School of Medicine, Kawasaki, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Sumida
authors.forename: I
authors.initials: I
authors.lastname: Matsumoto
authors.forename: T
authors.initials: T
authors.lastname: Maeda
authors.forename: K
authors.initials: K
authors.lastname: Nishioka
mesh_terms: D006801:Humans; D011948:Receptors, Antigen, T-Cell / Q000737:chemistry / Q000276:immunology*; D012859:Sjogren's Syndrome / Q000276:immunology*; D013601:T-Lymphocytes / Q000737:chemistry / Q000276:immunology*
chemical_list: D011948:Receptors, Antigen, T-Cell