title: Spontaneous regression of metastatic renal cancer. Case report and literature review.
abstract: A case of spontaneous regression of pleural and intrapulmonary metastases from renal cell cancer is reported with more than 60 cases reported since the original review of this clinical phenomenon in 1964. The metastatic disease sites are most often pulmonary, but extrapulmonary sites include liver, bone, and CNS regressions. The role of nephrectomy in "spontaneous regression" continues to be obscure, accounting for < 50% of documented cases. Immunologic mechanisms, although intellectually attractive, have not been identified.
authors.affiliation: Cancer Center of Boston at Plymouth, Framingham, MA, USA.
authors.forename: J
authors.initials: J
authors.lastname: Lokich
mesh_terms: D018262:Adenocarcinoma, Clear Cell / Q000473:pathology / Q000601:surgery; D018249:Adenoma, Oxyphilic / Q000473:pathology / Q000601:surgery; D001859:Bone Neoplasms / Q000556:secondary; D002292:Carcinoma, Renal Cell / Q000473:pathology / Q000556:secondary* / Q000601:surgery; D016543:Central Nervous System Neoplasms / Q000556:secondary; D005500:Follow-Up Studies; D006801:Humans; D007680:Kidney Neoplasms / Q000473:pathology* / Q000601:surgery; D008113:Liver Neoplasms / Q000556:secondary; D008175:Lung Neoplasms / Q000473:pathology / Q000556:secondary*; D008297:Male; D008875:Middle Aged; D009365:Neoplasm Regression, Spontaneous; D009378:Neoplasms, Multiple Primary / Q000473:pathology / Q000601:surgery; D009392:Nephrectomy; D010997:Pleural Neoplasms / Q000473:pathology / Q000556:secondary*