title: Clinical significance of urinary human tissue non-specific alkaline phosphatase (hTNAP) in pre-eclampsia and eclampsia.
abstract: The aim of this work was to determine the levels of urinary human tissue non-specific alkaline phosphatase (hTNAP) in pre-eclampsia and eclampsia in order to assess renal tubular damage. Urine samples were collected from 26 mild pre-eclamptic, 26 were pre-eclamptic, 20 eclamptic patients and 20 healthy pregnant women (controls) in their late third trimester. Urinary hTNAP/creatinine (hTNAP/cr) in severe pre-eclampsia and eclampsia were significantly higher than in controls. Urinary hTNAP/cr was increased in 23%, 77% and 90% of cases of mild pre-eclampsia, severe pre-eclampsia and eclampsia, respectively, indicating that the increase correlates with the severity of the disease. Marked elevation or urinary hTNAP/cr was also associated with bad fetal outcome. These results provide additional evidence for renal tubular damage in pre-eclampsia and eclampsia.
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Medicine, Cairo, Egypt.
authors.forename: M
authors.initials: M
authors.lastname: Shaarawy
authors.forename: S Y
authors.initials: SY
authors.lastname: el Mallah
authors.forename: A A
authors.initials: AA
authors.lastname: el-Yamani
mesh_terms: D000328:Adult; D000469:Alkaline Phosphatase / Q000652:urine*; D001774:Blood Chemical Analysis; D001794:Blood Pressure; D003404:Creatinine / Q000652:urine; D004461:Eclampsia / Q000473:pathology / Q000652:urine*; D005260:Female; D005865:Gestational Age; D006801:Humans; D007684:Kidney Tubules / Q000473:pathology; D011225:Pre-Eclampsia / Q000473:pathology / Q000652:urine*; D011247:Pregnancy; D011256:Pregnancy Outcome; D013379:Substrate Specificity
chemical_list: D003404:Creatinine; D000469:Alkaline Phosphatase