Dexamethasone-induced leucocytosis in pregnancy.
The effect of intramuscular dexamethasone administration in late pregnancy on the maternal peripheral white cell count was examined in 20 women. The mean total white cell count increased from a baseline of 11.3 x 10(9)/L (SD 2.3) to 16.2 x 10(9)/L (SD 4.6) on day 1, normalising thereafter. This 43% increase represented composite changes in the neutrophil and lymphocyte counts which, on average, increased by 62% and decreased by 22%, respectively. It is concluded that prenatal dexamethasone induces a significant neutrophilia on the first day following administration. This information may be helpful when monitoring for infection.
Denison
F C
FC
Simpson Memorial Maternity Pavilion, Royal Infirmary of Edinburgh NHS Trust.
Elliott
C L
CL
Wallace
E M
EM
D000293:Adolescent; D000328:Adult; D003907:Dexamethasone / Q000009:adverse effects*; D005260:Female; D005865:Gestational Age; D005938:Glucocorticoids / Q000009:adverse effects*; D006801:Humans; D007958:Leukocyte Count; D007964:Leukocytosis / Q000139:chemically induced*; D009503:Neutropenia / Q000139:chemically induced; D011247:Pregnancy; D011248:Pregnancy Complications / Q000139:chemically induced* / Q000188:drug therapy
D005938:Glucocorticoids; D003907:Dexamethasone