title: Platelet aggregation and lipid profile in offsprings of young ischemics.
abstract: OBJECTIVE
  To study the platelet aggregation and lipid profile in offsprings of young ischemic parents.
  
  
  METHODS
  Cross sectional.
  
  
  METHODS
  Hospital based.
  
  
  METHODS
  40 adults under 45 years of age with proven CHD and their 50 offsprings comprised the study group. In the control group, 40 age matched adults with normal maximal treadmill test and their 50 off springs were included. All were screened for lipid profile and platelet aggregation.
  
  
  RESULTS
  Platelet aggregation was significantly elevated in adults with CHD (44.0 +/- 15.5%) compared to controls (32.22 +/- 9.1%). Children of CHD adults also had significantly elevated aggregation (34.9 +/- 12.5%) compared to control offsprings (27.8 +/- 9.9%). Adult CHD subjects had significantly elevated serum cholesterol, LDL-cholesterol (LDL-C) and atherogenic index compared to control adults. The children in both groups had similar lipid profiles.
  
  
  CONCLUSIONS
  Platelet aggregation is enhanced in offsprings of young ischemics. The potential of this index as a marker for early development of CHD needs to be explored.
authors.affiliation: Department of Pediatrics, Maulana Azad Medical College, New Delhi.
authors.forename: A
authors.initials: A
authors.lastname: Khalil
authors.forename: D
authors.initials: D
authors.lastname: Kumar
authors.forename: M
authors.initials: M
authors.lastname: Venkatesan
mesh_terms: D000293:Adolescent; D000328:Adult; D001161:Arteriosclerosis / Q000235:genetics / Q000503:physiopathology; D015415:Biomarkers; D002648:Child; D002675:Child, Preschool; D002784:Cholesterol / Q000097:blood*; D003327:Coronary Disease / Q000235:genetics / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D010974:Platelet Aggregation; D014280:Triglycerides / Q000097:blood*
chemical_list: D015415:Biomarkers; D014280:Triglycerides; D002784:Cholesterol