title: Endoscopic injection of collagen for the treatment of female urinary stress incontinence.
abstract: BACKGROUND
  The objective of our study was to assess the efficacy and safety of glutaraldehyde cross-linked collagen injection in the treatment of female urinary stress incontinence.
  
  
  METHODS
  We conducted a retrospective analysis of the records of 105 women who underwent collagen injection for urinary stress incontinence between March 1991 and April 1995. Preoperative assessment included uroflowmetry, residual urine determination, and urodynamic studies.
  
  
  RESULTS
  Of the 105 women in our series, 95 patients (90.5%) had initial successful results at 3 months (61.0% cured, 29.5% significantly improved) while 4 patients (3.8%) had slight improvement and 6 (5.7%) failed surgical correction. One year after the procedure, the success rate dropped to 81.9% (86 patients) with 46.7% cured and 35.2% significantly improved. Nine patients (8.6%) had slight improvement and 10 patients (9.5%) failed surgical correction. Eight patients (7.6%) with initial unsatisfactory results underwent additional sessions of collagen injection and were subsequently either cured or had significant improvement. Twenty-three patients (21.9%) suffered a relapse. The mean time to relapse was 13.3 months, and 6 of those who relapsed underwent repeated injections with favorable results. Complications were minimal; 6 patients had temporary retention of urine, and 2 patients had urinary tract infections.
  
  
  CONCLUSIONS
  We conclude that glutaraldehyde cross-linked collagen injection is a simple and safe method of treatment for urinary stress incontinence. A longer follow-up period is necessary to assess the long-term efficacy of this treatment.
authors.affiliation: Division of Urology, Toa Payoh Hospital, Singapore.
authors.forename: L P
authors.initials: LP
authors.lastname: Ang
authors.forename: K P
authors.initials: KP
authors.lastname: Tay
authors.forename: P H
authors.initials: PH
authors.lastname: Lim
authors.forename: H C
authors.initials: HC
authors.lastname: Chng
mesh_terms: D000328:Adult; D000368:Aged; D003094:Collagen / Q000008:administration & dosage*; D003432:Cross-Linking Reagents / Q000008:administration & dosage; D003558:Cystoscopy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D012008:Recurrence; D012189:Retrospective Studies; D016896:Treatment Outcome; D014521:Urethra; D014550:Urinary Incontinence, Stress / Q000628:therapy*
chemical_list: D003432:Cross-Linking Reagents; D003094:Collagen