A new system analysis of motor and locomotor activities associated with a microdialysis study of pressure-induced dopamine increase in rats.
In this work, we report a new analysis system to quantify the behavioral disorders observed in the model of the rat submitted to high pressure and monitored by piezoelectric sensor. The major advance consists in a spectral 3D representation of LMA and tremor, which provides a better selectivity than previous systems. This behavioral processing indicated that tremor is characterized by a 7-14 Hz frequency band and LMA by a 20-35 Hz frequency band. The association of this system to the microdialysis technique to simultaneously evaluate the striatal DA level confirms that pressure-induced striatal DA increase is in great part linked to the LMA, and supports the concept of a complex ethiology for this symptom. We conclude that this new behavioral system analysis associated with microdialysis study constitutes a powerful tool to investigate the role of different neurotransmitters in the occurrence of the behavioral components described in the HPNS of rats.
Darbin
O
O
CNRS-URA 1630, Institut J. Roche, Faculté de Médecine Nord, Marseille, France.
Risso
J J
JJ
Rostain
J C
JC
D000399:Air Pressure; D000818:Animals; D001923:Brain Chemistry / Q000502:physiology*; D003196:Computer Graphics; D004298:Dopamine / Q000378:metabolism / Q000502:physiology*; D005110:Extracellular Space / Q000378:metabolism; D006948:Hyperkinesis / Q000503:physiopathology; D008297:Male; D017551:Microdialysis; D009043:Motor Activity / Q000502:physiology*; D009207:Myoclonus / Q000378:metabolism; D017072:Neostriatum / Q000378:metabolism; D018377:Neurotransmitter Agents / Q000378:metabolism; D011589:Psychology, Experimental / Q000295:instrumentation*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014202:Tremor / Q000503:physiopathology; D014732:Vibration
D018377:Neurotransmitter Agents; D004298:Dopamine