title: Assessment of chlorpromazine as radiation sensitizer and protector.
abstract: In vitro studies of chlorpromazine (CPZ) a popular anti-psychotic drug has shown radiation sensitizing effects at higher celluar concentration and protective effect at a lower concentration. The present study was designed to evaluate both sensitizing and protective effects in the treatment of advanced cancer of the cervix treated with hypofractionated external radiation and intratumoural injection of chlopromazine. Twenty patients were treated with intratumoural CPZ and radiation, while, 23 patients received radiation alone. A 52.94% complete response was noted in CPZ arm while 39.1% complete response in the control. A trend towards improved response is seen in CPZ group. Similarly patients who received CPZ showed significantly low proctitis rates.
authors.affiliation: Division of Radiation Oncology, Dr. Balabhai Nanavati Hospital, Mumbai, India.
authors.forename: N G
authors.initials: NG
authors.lastname: Huilgol
authors.forename: N
authors.initials: N
authors.lastname: Chatterjee
authors.forename: B B
authors.initials: BB
authors.lastname: Singh
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000532:radiotherapy*; D002746:Chlorpromazine / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D015552:Injections, Intralesional; D011837:Radiation-Protective Agents / Q000627:therapeutic use*; D011838:Radiation-Sensitizing Agents / Q000627:therapeutic use*; D002583:Uterine Cervical Neoplasms / Q000532:radiotherapy*
chemical_list: D011837:Radiation-Protective Agents; D011838:Radiation-Sensitizing Agents; D002746:Chlorpromazine