[Effect of L-carnitine on lipid peroxidation and lipid composition in blood serum in hemic hypoxia].
Sodium nitrite has been studied for its effect on lipid metabolism of Wistar line rats. It is shown that a single administration of sodium nitrite in account 5 mg per 100 g of the body weight results in the intensification of lipids peroxidation, hyperbetalipoproteinemia, hypertriglyceridemia, hypercholesterolemia and to the decrease of the coefficient phospholipids/cholesterin/. Prophylactic administration of carnitine chloride in account of 20 mg per 100 g of the body weight stabilizes the level of lipids peroxidation, decreases concentration of total lipids, triglycerides, total cholesterin, phospholipids, lipoproteids of low and very low density, in the rat blood serum, normalizes the coefficient phospholipids/cholesterin.
Sidoriak
N G
NG
Volgin
D V
DV
D000208:Acute Disease; D000818:Animals; D002331:Carnitine / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D000860:Hypoxia / Q000139:chemically induced / Q000517:prevention & control*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008055:Lipids / Q000097:blood*; D008077:Lipoproteins, LDL / Q000097:blood; D008079:Lipoproteins, VLDL / Q000097:blood; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D051381:Rats; D017208:Rats, Wistar; D012977:Sodium Nitrite / Q000506:poisoning*
D008055:Lipids; D008077:Lipoproteins, LDL; D008079:Lipoproteins, VLDL; D008315:Malondialdehyde; D012977:Sodium Nitrite; D002331:Carnitine
Vliianie L-karnitina na peroksidnoe okislenie lipidov i lipidnyĭ sostav syvorotki krovi pri gemicheskoĭ gipoksii.