Chronic granulomatous disease: a case report.
Chronic granulomatous disease is an uncommon inherited disease with presentations of frequent pyogenic and fungal infections. In this disease, the phagocytes ingest pathogens, but the ingested microorganisms can not be killed because the cells lack the ability to convert oxygen into superoxide using the enzyme known as NADPH oxidase. We report on a patient who had experienced frequent lymphadenopathy and bacterial infections since childhood. In addition to his history of repeated bacterial infections, diagnosis was also based on abnormal findings in immunologic tests including the nitroblue tetrazolium test assay, analysis of chemiluminescence and detection of hydrogen peroxide using flow cytometry. He received prophylactic treatment with antibiotics, and the condition remained stable during a six-month follow-up period.
Yeh
K W
KW
Department of Pediatrics, Chang Gung Children's Hospital, Taipei, Taiwan, R.O.C.
Huang
J L
JL
Kong
M S
MS
D002675:Child, Preschool; D006105:Granulomatous Disease, Chronic / Q000235:genetics / Q000276:immunology* / Q000628:therapy; D006801:Humans; D008297:Male; D019255:NADPH Oxidases / Q000378:metabolism
D019255:NADPH Oxidases