title: Nucleotide sequence of equine MxA cDNA.
abstract: A 2.6 kb cDNA species has been isolated from a cDNA library prepared from interferon-alpha stimulated equine peripheral blood leucocytes and the nucleotide sequence determined. The cDNA has a single open reading frame potentially encoding a 660 amino acid polypeptide showing a high degree of homology with known mammalian Mx proteins, including the possession of three consensus GTP-binding motifs. The protein has a calculated pI = 6.1 and in accordance with proposed nomenclature we have designated it equine MxA.
authors.affiliation: Department of Pathology and Infectious Diseases, The Royal Veterinary College, London, UK.
authors.forename: P M
authors.initials: PM
authors.lastname: Chesters
authors.forename: M
authors.initials: M
authors.lastname: Steele
authors.forename: A
authors.initials: A
authors.lastname: Purewal
authors.forename: N
authors.initials: N
authors.lastname: Edington
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D019204:GTP-Binding Proteins; D006736:Horses; D008969:Molecular Sequence Data; D064547:Myxovirus Resistance Proteins; D014176:Protein Biosynthesis; D011506:Proteins / Q000235:genetics* / Q000378:metabolism; D017422:Sequence Analysis, DNA
chemical_list: D064547:Myxovirus Resistance Proteins; D011506:Proteins; D019204:GTP-Binding Proteins