In vitro activity of trimethoprim against Borrelia burgdorferi.
A new culture medium has been developed to evaluate the activity of trimethoprim and sulfamethoxazole against Borrelia burgdorferi in vitro. In this specially modified Barbour-Stoenner-Kelly medium, in which antagonizing substances were reduced to a minimum, trimethoprim was more active against Borrelia burgdorferi than against a sensitive strain of Escherichia coli, but sulfamethoxazole was not active against Borrelia burgdorferi.
Reisinger
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EC
Department of Medicine, Karl-Franzens University, Graz, Austria.
Wendelin
I
I
Gasser
R
R
D000900:Anti-Bacterial Agents; D000892:Anti-Infective Agents, Urinary / Q000494:pharmacology*; D015748:Borrelia burgdorferi Group / Q000187:drug effects* / Q000502:physiology; D015169:Colony Count, Microbial; D003470:Culture Media / Q000737:chemistry*; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects* / Q000502:physiology; D008826:Microbial Sensitivity Tests; D013420:Sulfamethoxazole / Q000494:pharmacology*; D014295:Trimethoprim / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D000892:Anti-Infective Agents, Urinary; D003470:Culture Media; D014295:Trimethoprim; D013420:Sulfamethoxazole