title: Chronic diffuse sclerosing osteomyelitis of the mandible or mandibular location of S.A.P.H.O. syndrome.
abstract: The chronic diffuse sclerosing osteomyelitis (CDSO) of the mandible has been described as an inflammatory disease characterized by recurrent episodes of intense pain in the mandible, often accompanied by trismus, paresthesia and progressive mandibular deformity. The etiopathogeny of this entity is not fully known. The differential diagnosis must be carried out very carefully, and the treatment results are very disappointing. Recently, evidence that suggests that CDSO may be the mandibular location of a more diffuse condition, the synovitis, acne, pustulosis, hyperostosis, osteitis (SAPHO) syndrome, has been offered. We describe two clinical cases of CDSO of typical evolution which fulfill the criteria for SAPHO syndrome, offering us an occasion for a review of the current literature.
authors.affiliation: Section of Oral and Maxillofacial Surgery, Hospital Son Dureta, Palma de Mallorca, Spain.
authors.forename: F
authors.initials: F
authors.lastname: García-Marín
authors.forename: J I
authors.initials: JI
authors.lastname: Iriarte-Ortabe
authors.forename: H
authors.initials: H
authors.lastname: Reychler
mesh_terms: D000152:Acne Vulgaris / Q000473:pathology*; D000328:Adult; D000658:Amoxicillin / Q000627:therapeutic use; D019980:Amoxicillin-Potassium Clavulanate Combination; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D002908:Chronic Disease; D002969:Clavulanic Acids / Q000627:therapeutic use; D003937:Diagnosis, Differential; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D005500:Follow-Up Studies; D006801:Humans; D015576:Hyperostosis / Q000473:pathology*; D008297:Male; D008336:Mandibular Diseases / Q000175:diagnosis* / Q000473:pathology; D008875:Middle Aged; D010000:Osteitis / Q000473:pathology*; D010019:Osteomyelitis / Q000175:diagnosis* / Q000473:pathology; D010404:Penicillin V / Q000627:therapeutic use; D010406:Penicillins / Q000627:therapeutic use; D011565:Psoriasis / Q000473:pathology*; D012598:Sclerosis; D013577:Syndrome; D013585:Synovitis / Q000473:pathology*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D002969:Clavulanic Acids; D010406:Penicillins; D019980:Amoxicillin-Potassium Clavulanate Combination; D000658:Amoxicillin; D010404:Penicillin V