Expression of dopamine D2 receptor mRNA isoforms in the carotid body of rat, cat and rabbit.
Using the Reverse transcription-Polymerase chain reaction, we detected dopamine D2 receptor mRNA short and long isoforms in the adult carotid body of rats, cats, and rabbits. For these animals, the relative short/long ratios were 0.60, 0.65 and 0.57, respectively. Our results suggest that the variety of dopamine effects on carotid chemoreceptor activity, that has been related to species differences, may not be dependent on the expression levels of the dopamine D2 receptor mRNA isoforms in the studied species.
Bairam
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Unite de Recherche en Néonatologie, Centre de Recherche, CHUQ, Pavillon Saint Francois d'Assise, Université Laval, Québec, Qué., Canada. aida.bairam@crsfa.ulaval.ca
Khandjian
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D000818:Animals; D002344:Carotid Body / Q000378:metabolism*; D002415:Cats; D003342:Corpus Striatum / Q000378:metabolism; D005260:Female; D008297:Male; D016133:Polymerase Chain Reaction; D012333:RNA, Messenger / Q000378:metabolism; D011817:Rabbits; D051381:Rats; D017207:Rats, Sprague-Dawley; D017448:Receptors, Dopamine D2 / Q000378:metabolism*; D013237:Stereoisomerism
D012333:RNA, Messenger; D017448:Receptors, Dopamine D2