Pyrazinamide-induced granulomatous hepatitis.
Noncaseating granulomatous hepatitis may be caused by a variety of drugs, but we have not found, by computer search of the literature, a previous describe of granulomatous hepatitis associated with pyrazinamide. We describe a 52-year-old man with hectic fever, chills, extreme fatigue, liver damage, and hyperuricemia about 4 weeks after commencing pyrazinamide therapy. A liver biopsy specimen showed noncaseating epithelioid granulomas. The patient recovered soon after the interruption of tuberculostatic treatment.
Knobel
B
B
Department of Medicine B, Edith Wolfson Medical Center, Holon, Israel.
Buyanowsky
G
G
Dan
M
M
Zaidel
L
L
D000995:Antitubercular Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001706:Biopsy; D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis / Q000209:etiology*; D004359:Drug Therapy, Combination; D006099:Granuloma / Q000139:chemically induced* / Q000175:diagnosis; D006801:Humans; D007538:Isoniazid / Q000009:adverse effects / Q000627:therapeutic use; D008099:Liver / Q000473:pathology; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D011718:Pyrazinamide / Q000009:adverse effects* / Q000627:therapeutic use; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy
D000995:Antitubercular Agents; D011718:Pyrazinamide; D007538:Isoniazid