[Syncope with long QT interval in a 39 day-old infant treated with cisapride].
Cardiotoxicity of cisapride may increase when this drug is associated with ranitidine.


METHODS
A 37-day old term infant, treated with cisapride (1.2 mg/kg/d) and ranitidine for regurgitations, was hospitalized for malaise. A prolonged QT interval (with isolate ventricular extrasystoles), noted at admission, disappeared rapidly after cisapride withdrawal. Linkage to cisapride was probable, promoted by high dosage and cisapride metabolism inhibition by ranitidine, but its plasma concentration was not measured.


CONCLUSIONS
This case report stresses the problem of cisapride dosage in infants and the question of an interaction between cisapride and ranitidine.
Valdes
L
L
Service de pédiatrie générale, hôpital Louis-Mourier, Colombes, France.
Champel
V
V
Olivier
C
C
Jonville-Bera
A P
AP
Autret
E
E
D000897:Anti-Ulcer Agents / Q000009:adverse effects* / Q000627:therapeutic use; D020117:Cisapride; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D005764:Gastroesophageal Reflux / Q000188:drug therapy; D006635:Histamine H2 Antagonists / Q000627:therapeutic use; D006801:Humans; D007223:Infant; D008133:Long QT Syndrome / Q000139:chemically induced* / Q000150:complications; D008297:Male; D010880:Piperidines / Q000009:adverse effects* / Q000627:therapeutic use; D011899:Ranitidine / Q000627:therapeutic use; D013575:Syncope / Q000139:chemically induced* / Q000150:complications
D000897:Anti-Ulcer Agents; D006635:Histamine H2 Antagonists; D010880:Piperidines; D011899:Ranitidine; D020117:Cisapride
Malaise avec allongement de l'espace QT chez un nourrisson de 39 jours traité par cisapride.