title: Propagation of activity-dependent synaptic depression in simple neural networks.
abstract: Triple whole-cell recordings from simple networks of cultured hippocampal neurons show that Induction of long-term depression at glutamatergic synapses is accompanied by a back propagation of depression to Input synapses on the dendrite of the presynaptic neuron. The depression also propagates laterally to divergent outputs of the presynaptic neuron and to convergent inputs on the postsynaptic neuron. There is no forward propagation of depression to the output of the postsynaptic neuron and no presynaptic propagation accompanying long-term depression at GABAergic synapses. Activity-induced synaptic modification is therefore not restricted to the activated synapse, but selectively propagates throughout the neural network.
authors.affiliation: Department of Biology, University of California at San Diego, La Jolla 92093-0357, USA.
authors.forename: R M
authors.initials: RM
authors.lastname: Fitzsimonds
authors.forename: H J
authors.initials: HJ
authors.lastname: Song
authors.forename: M M
authors.initials: MM
authors.lastname: Poo
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D018698:Glutamic Acid / Q000378:metabolism; D006624:Hippocampus / Q000166:cytology / Q000502:physiology; D008564:Membrane Potentials; D009415:Nerve Net / Q000502:physiology*; D009433:Neural Inhibition; D009473:Neuronal Plasticity / Q000502:physiology*; D051381:Rats; D013569:Synapses / Q000502:physiology*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
chemical_list: D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid