[Serum levels and in vitro production of IL-5 in children with bronchial asthma].
IL-5 play important roles in inflammatory responses in bronchial asthma, but little is known about serum levels and in vitro production of IL-5 in childhood bronchial asthma. We further examined serum IL-5 levels in children with bronchial asthma and the controls. IL-5 in serum was detected in all of asthmatic and disease-free individuals. Its values during asthma exacerbation were significantly higher than during remission of asthma. Serum IL-5 values did not significantly differ among groups divided by asthma severity. We studied IL-5 production by peripheral blood mononuclear cells cultured with or without Dermatophagoides farinae (Df) in children with mite allergy. IL-5 concentrations in culture supernatant from after stimulation with Df were significantly higher than those from asthmatic patients without stimulation and from the control subjects. In contrast, IL-5 levels in culture media from the controls were not significantly different between with and without stimulation with Df. Our results suggest that IL-5 may play roles in the pathogenesis of bronchial asthma.
Ikeda
N
N
Department of Pediatrics, Mizonokuchi Hospital, Teikyo University School of Medicine.
Ishiguro
A
A
Uno
K
K
Inaba
Y
Y
Ishikita
T
T
Takahashi
H
H
Shimbo
T
T
D001249:Asthma / Q000097:blood*; D002648:Child; D006801:Humans; D066298:In Vitro Techniques; D015848:Interleukin-5 / Q000096:biosynthesis / Q000097:blood*; D009000:Monocytes / Q000378:metabolism*
D015848:Interleukin-5