Thrombophilia and fetal loss.
Recurrent fetal loss and other placental vascular pathologies of pregnancy have long been associated with antiphospholipid syndrome-an acquired autoimmune thrombophilic state. The number of known heritable thrombophilic disorders has grown rapidly in recent years with the identification of activated protein C resistance, factor V Leiden mutation and hyperhomocysteinemia as major causes of thrombosis. Data accumulated over the past two years suggest that heritable thrombophilia is associated with increased risk of fetal loss and pre-eclampsia. The present review discusses potential pathogenetic mechanisms for this association and evaluates reported therapeutic regimes for the prevention of fetal loss in women with thrombophilia.
Brenner
B
B
Rambam Medical Center, Haifa, Israel.
Blumenfeld
Z
Z
D000026:Abortion, Habitual / Q000209:etiology* / Q000517:prevention & control; D005165:Factor V / Q000235:genetics; D005260:Female; D005313:Fetal Death / Q000209:etiology* / Q000517:prevention & control; D006801:Humans; D009154:Mutation; D010922:Placenta Diseases / Q000150:complications* / Q000473:pathology; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000473:pathology*; D011250:Pregnancy Complications, Hematologic / Q000473:pathology*; D011486:Protein C / Q000378:metabolism; D013927:Thrombosis / Q000150:complications* / Q000473:pathology
D011486:Protein C; C095381:factor V Leiden; D005165:Factor V