Phosphoinositide 3-kinases: a conserved family of signal transducers.
Phosphoinositide 3-kinases (PI3Ks) generate lipids that are implicated in receptor-stimulated signalling and in the regulation of membrane traffic. Several distinct classes of PI3Ks have now been identified that have been conserved throughout eukaryotic evolution. Potential signalling pathways downstream of PI3Ks have been elucidated and PI3K function is now being characterised in several model organisms.
Vanhaesebroeck
B
B
Ludwig Institute for Cancer Research, London, UK.
Leevers
S J
SJ
Panayotou
G
G
Waterfield
M D
MD
D000818:Animals; D017173:Caenorhabditis elegans / Q000201:enzymology; D004023:Dictyostelium / Q000201:enzymology; D004331:Drosophila melanogaster / Q000201:enzymology; D008563:Membrane Lipids / Q000378:metabolism; D008969:Molecular Sequence Data; D019869:Phosphatidylinositol 3-Kinases; D017853:Phosphotransferases (Alcohol Group Acceptor) / Q000737:chemistry / Q000145:classification / Q000378:metabolism; D015398:Signal Transduction; D013379:Substrate Specificity
D008563:Membrane Lipids; D019869:Phosphatidylinositol 3-Kinases; D017853:Phosphotransferases (Alcohol Group Acceptor)