Detection of circulating antigens in blood to evaluate treatment of fascioliasis.
This work was designed to assess cure of human fascioliasis after triclabendazole treatment by detection of Fasciola antigen by a modified double antibody sandwich ELISA technique. The results showed that the test detected the antigen in the sera of all studied cases before treatment, while no antigen was detected after treatment. The results may suggest that antigen detection provides an accurate tool for diagnosis as well as the assessment of cure.
Hammouda
N A
NA
Department of Parasitology, Faculty of Medicine, University of Alexandria, Egypt.
el Mansoury
S T
ST
el Azzouni
M Z
MZ
Hussein
E D
ED
D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use*; D000909:Antibodies, Helminth; D000947:Antigens, Helminth / Q000097:blood*; D001562:Benzimidazoles / Q000627:therapeutic use*; D016903:Drug Monitoring / Q000379:methods; D004797:Enzyme-Linked Immunosorbent Assay; D005211:Fascioliasis / Q000097:blood / Q000188:drug therapy*; D006168:Guinea Pigs; D006801:Humans; D012016:Reference Values; D000077682:Triclabendazole
D000871:Anthelmintics; D000909:Antibodies, Helminth; D000947:Antigens, Helminth; D001562:Benzimidazoles; D000077682:Triclabendazole