Carcinomatous change in the cranial metastasis from a metastasizing mixed tumor of the salivary gland--case report.
A 57-year-old female who had had a mixed tumor of the submandibular gland for 30 years presented with a cranial metastasis in the ipsilateral occipital region. Detailed histological examinations of the primary tumor failed to detect any carcinomatous component. In contrast, the metastasis contained a carcinomatous component. This histological discrepancy was confirmed by assessment of the expression of Ki-67 antigen in these tumor specimens and comparison with five typical benign mixed tumors. Cranial metastasis of a histologically benign mixed tumor is extremely rare, and a carcinomatous change in the metastatic tumor is apparently unique.
Fujimura
M
M
Department of Neurosurgery, Iwate Prefectural Central Hospital, Morioka.
Sugawara
T
T
Seki
H
H
Otawara
Y
Y
Sakuma
T
T
Nakano
Y
Y
Yoshimoto
T
T
D008949:Adenoma, Pleomorphic / Q000473:pathology*; D001932:Brain Neoplasms / Q000556:secondary*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009778:Occipital Lobe; D013365:Submandibular Gland Neoplasms / Q000473:pathology*