title: Effect of lactulose on bacterial translocation.
abstract: OBJECTIVE
  To find out if lactulose can prevent the bacterial translocation that is induced by obstructive jaundice in rats.
  
  
  METHODS
  Laboratory experiment.
  
  
  METHODS
  Teaching hospital, Turkey.
  
  
  METHODS
  50 male Wistar-albino rats.
  
  
  METHODS
  10 rats were not operated on and used as controls; 20 rats underwent laparotomy and sham ligation of the common bile duct (CBD); 20 had the CBD ligated alone; and 20 had the CBD ligated and were given oral lactulose 2 ml/day until death. All rats were killed after 14 days.
  
  
  METHODS
  Presence of Escherichia coli in mesenteric lymph nodes (MLN), and bacterial overgrowth as indicated by counts of E coli in the caecum.
  
  
  RESULTS
  There was significantly less bacterial translocation to MLN in the group that had been given lactulose compared with CBD-ligated and lactulose not given (2/20 compared with 8/20, p = 0.06). There was also a significant reduction in the number of Gram negative bacteria in that group (p = < 0.01).
  
  
  CONCLUSIONS
  Lactulose seems to reduce the incidence of translocation from the gut to MLN in rats with obstructive jaundice.
authors.affiliation: Department of Surgery, Ankara University School of Medicine, Turkey.
authors.forename: C
authors.initials: C
authors.lastname: Ozaslan
authors.forename: A G
authors.initials: AG
authors.lastname: Türkçapar
authors.forename: M
authors.initials: M
authors.lastname: Kesenci
authors.forename: K
authors.initials: K
authors.lastname: Karayalçin
authors.forename: M A
authors.initials: MA
authors.lastname: Yerdel
authors.forename: S
authors.initials: S
authors.lastname: Bengisun
authors.forename: A
authors.initials: A
authors.lastname: Törüner
mesh_terms: D000818:Animals; D018988:Bacterial Translocation / Q000187:drug effects*; D002779:Cholestasis; D004195:Disease Models, Animal; D005765:Gastrointestinal Agents / Q000494:pharmacology*; D007792:Lactulose / Q000494:pharmacology*; D008208:Lymphatic System; D008297:Male; D051381:Rats; D017208:Rats, Wistar
chemical_list: D005765:Gastrointestinal Agents; D007792:Lactulose