title: Does oligoantigenic diet influence hyperactive/conduct-disordered children--a controlled trial.
abstract: A crossover 'placebo'-controlled, double-blind design was used to examine the effectiveness of an oligoantigenic diet in 49 children with hyperactive/disruptive behavior disorder. Effects of diet were compared with those yielded by stimulant medication (methylphenidate). The study was conducted in an inpatient unit at the Department of Child and Adolescent Psychiatry, Central Institute of Mental Health, Mannheim. Change in behavior was measured in standardized situations by trained raters, including behavior assessment when testing with CPT and PAT, during a free play situation, and at school. Twelve children (24%) showed significant behavioral improvement in two behavior ratings during diet relative to control diet conditions. Methylphenidate used in 36 children yielded more responders (44%) than diet. The amount of positive changes in behavior in those who received both treatments was about the same. Although only effective in a minority of children, dietary treatment cannot be neglected as a possible access to treating hyperactive/disruptive children and merits further investigation.
authors.affiliation: Central Institute of Mental Health, Department of Child and Adolescent Psychiatry, Mannheim, Germany.
authors.forename: M H
authors.initials: MH
authors.lastname: Schmidt
authors.forename: P
authors.initials: P
authors.lastname: Möcks
authors.forename: B
authors.initials: B
authors.lastname: Lay
authors.forename: H G
authors.initials: HG
authors.lastname: Eisert
authors.forename: R
authors.initials: R
authors.lastname: Fojkar
authors.forename: D
authors.initials: D
authors.lastname: Fritz-Sigmund
authors.forename: A
authors.initials: A
authors.lastname: Marcus
authors.forename: B
authors.initials: B
authors.lastname: Musaeus
mesh_terms: D001289:Attention Deficit Disorder with Hyperactivity / Q000178:diet therapy*; D000697:Central Nervous System Stimulants / Q000627:therapeutic use; D002648:Child; D002653:Child Behavior Disorders / Q000178:diet therapy*; D018592:Cross-Over Studies; D004311:Double-Blind Method; D005260:Female; D005503:Food Additives; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D008297:Male; D008774:Methylphenidate / Q000627:therapeutic use; D012720:Severity of Illness Index
chemical_list: D000697:Central Nervous System Stimulants; D005503:Food Additives; D008774:Methylphenidate; D007073:Immunoglobulin E