title: Growth hormone-releasing hormone (GRH)-producing pancreatic tumor with no evidence of multiple endocrine neoplasia type 1.
abstract: The characteristic features of a 48-year-old male presenting with isolated acromegaly caused by a GRH-producing pancreatic endocrine tumor bearing no relation to MEN1 was reported. The clinical features, laboratory findings, and sellar enlargement were improved after removal of the pancreatic tumor. The resected pancreatic tumor showed positive GRH immunoreactivity and contained abundant GRH mRNA. This tumor is extremely rare and to date only 10 cases have been reported. In the management of acromegaly, the measurement of GRH is recommended and the search for an ectopic source will prevent unnecessary and potentially ineffective pituitary surgery.
authors.affiliation: Second Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Kawa
authors.forename: T
authors.initials: T
authors.lastname: Ueno
authors.forename: A
authors.initials: A
authors.lastname: Iijima
authors.forename: T
authors.initials: T
authors.lastname: Midorikawa
authors.forename: Y
authors.initials: Y
authors.lastname: Fujimori
authors.forename: M
authors.initials: M
authors.lastname: Tokoo
authors.forename: H
authors.initials: H
authors.lastname: Oguchi
authors.forename: K
authors.initials: K
authors.lastname: Kiyosawa
authors.forename: Y
authors.initials: Y
authors.lastname: Imai
authors.forename: G
authors.initials: G
authors.lastname: Kaneko
authors.forename: T
authors.initials: T
authors.lastname: Kuroda
authors.forename: K
authors.initials: K
authors.lastname: Hashizume
authors.forename: R Y
authors.initials: RY
authors.lastname: Osamura
authors.forename: H
authors.initials: H
authors.lastname: Katakami
mesh_terms: D000172:Acromegaly / Q000209:etiology*; D013007:Growth Hormone-Releasing Hormone / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D018761:Multiple Endocrine Neoplasia Type 1; D010190:Pancreatic Neoplasms / Q000150:complications / Q000175:diagnosis / Q000378:metabolism* / Q000601:surgery
chemical_list: D013007:Growth Hormone-Releasing Hormone