CD8alphaalpha T cells in lesions of Listeria monocytogenes-infected beta2m-deficient mice.
The beta2-microglobulin (beta2m)-deficient mutant mice lack alphabeta TCR CD8alphabeta T cells. We found markedly impaired granuloma formation in Listeria monocytogenes-infected beta2m-/- mice. Abundant CD8alphaalpha T cells were identified in loosely structured infiltrative liver lesions. Microfluorescence analysis disclosed that these CD8alphaalpha T cells expressed mostly the gammadelta TCR. CD8alphaalpha T cells were also found in the spleen of Listeria-infected beta2m-/- mice. These data provide first evidence for CD8alphaalpha T cells in listerial lesions of beta2m-/- mice.
Thoma-Uszynski
S
S
Department of Immunology, University of Ulm, Albert-Einstein-Allee 11, Ulm, D-89070, Germany.
Emoto
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Kaufmann
S H
SH
D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000166:cytology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D005260:Female; D006099:Granuloma / Q000473:pathology; D008088:Listeriosis / Q000276:immunology* / Q000473:pathology; D008099:Liver / Q000166:cytology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000032:analysis; D013154:Spleen / Q000166:cytology; D001613:beta 2-Microglobulin / Q000172:deficiency*
D016692:Receptors, Antigen, T-Cell, gamma-delta; D001613:beta 2-Microglobulin