[Bone mass in celiac patients].
Bone mineral content was measured in the whole body, the spine (L2-L4) and hip by Dual Photonic Absorpciometry (densitometer Norland 2600 Gd-153), in seventeen celiac patients, aged 6 to 12 years, with good adherence to the gluten free diet. The diagnosed was made before 30 months of age in 50% of cases. Average treatment duration was 69.8 +/- 36 months. The randomly selected control group was composed of 48 school age children, of the same age and sex of patients. Total bone mass (TBM) and bone mineral density (BMD) were expressed as Z scores on the basis of normal values established by the authors in Chilean children. Celiac patients had lower TBM and BMD of whole body, than controls (-1.11 +/- 0.94 vs 0.00 +/- 0.85 and -0.59 +/- 0.76 vs 0.06 +/- 0.84, respectively) and at the spine (-0.79 +/- 1.04 vs 0.003 +/- 0.92 and -1.49 +/- 0.99 vs 0.06 +/- 0.87 respectively). A lower TBM was founded at the hip (-0.62 +/- 1.28 vs -0.08 +/- 0.82) without differences in BMD. Celiac patients had a lower bone mass than controls despite early diagnosis and good compliance with the gluten-free diet. These differences could not be atributed entirely to the lower height of celiac patients. These results suggest that celiac patients constitute a risk group for development of osteoporosis later in life. This fact should be taken into consideration in the treatment of this condition.
Leiva
L
L
Unidad de Endrocrinología, Instituto de Nutrición y Tecnología de los Alimentos (INTA), Universidad de Chile.
Burrows
R
R
Ríos
G
G
Bergenfried
C
C
Larrain
F
F
Wenger
J
J
Lillo
R
R
Espinoza
J
J
Pumarino
H
H
Muzzo
S
S
D015519:Bone Density; D002136:Calcium, Dietary / Q000008:administration & dosage; D002446:Celiac Disease / Q000178:diet therapy / Q000503:physiopathology*; D002648:Child; D003720:Densitometry / Q000379:methods; D004032:Diet; D004044:Dietary Proteins / Q000008:administration & dosage; D002149:Energy Intake; D005260:Female; D005983:Glutens; D006801:Humans; D008159:Lumbar Vertebrae; D010024:Osteoporosis; D016226:Phosphorus, Dietary / Q000008:administration & dosage; D012307:Risk Factors
D002136:Calcium, Dietary; D004044:Dietary Proteins; D016226:Phosphorus, Dietary; D005983:Glutens
Masa ósea en pacientes con enfermedad celiaca.