[Changes in the oxytocinergic neurosecretory cells in the accessory magnocellular neuroendocrine nuclei of the rat hypothalamus during aging].
Histophysiology of accessory magnocellular nuclei of hypothalamus was studied in young (3-6 months) and old (14-29 months) male Wistar rats. Using non-labeled antibodies to oxytocin and karyolometry activation of protein synthesis combined with inhibition of oxytocin transport along the fibres was shown to occur in 4 (circular, fornical, dorso- and ventrolateral) of 5 accessory nuclei in old rats. This was not observed in anterior commissural nucleus. A hypothesis on compensatory role of accessory magnocellular nuclei of hypothalamus in regulation of neuroendocrine homeostasis in old rats is discussed.
Bazhanova
E D
ED
Grinevich
V V
VV
Danilova
O A
OA
Chernigovskaia
E V
EV
D000375:Aging / Q000378:metabolism*; D000818:Animals; D002466:Cell Nucleolus / Q000378:metabolism / Q000648:ultrastructure; D007031:Hypothalamus / Q000378:metabolism* / Q000648:ultrastructure; D007150:Immunohistochemistry; D008297:Male; D009490:Neurosecretory Systems / Q000378:metabolism* / Q000648:ultrastructure; D010121:Oxytocin / Q000096:biosynthesis*; D051381:Rats; D017208:Rats, Wistar; D018045:Receptors, Oxytocin / Q000378:metabolism* / Q000648:ultrastructure
D018045:Receptors, Oxytocin; D010121:Oxytocin
Izmeneniia oksitotsinergicheskikh neĭrosekretornykh kletok v dobavochnykh krupnokletochnykh neĭroéndokrinnykh iadrakh gipotalamusa u krys pri starenii.