Genetic polymorphism of cytochrome P450 as a biomarker of susceptibility to environmental toxicity.
Cytochrome P450 (CYP) enzymes are responsible for the metabolism of numerous xenobiotics and endogenous compounds, including the metabolic activation of most environmental toxic chemicals and carcinogens. Both metabolic and genetic polymorphisms have been identified for human CYP enzymes. The association of CYP genetic polymorphism and human cancer risk, and susceptibility to environmental hazards, have received increasing attention. This article briefly reviews the approaches and methods currently used in CYP genetic polymorphism studies. In addition, the current status and perspectives of using CYP genetic polymorphism as a biomarker of individual susceptibility to cancer and environmental toxicity are discussed.
Hong
J Y
JY
College of Pharmacy, Rutgers University, Piscataway, New Jersey 08864, USA. jyhong@rci.rutgers.edu
Yang
C S
CS
D015415:Biomarkers; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics*; D005838:Genotype; D015386:Hazardous Substances / Q000378:metabolism / Q000633:toxicity*; D006801:Humans; D009369:Neoplasms / Q000209:etiology*; D010641:Phenotype; D011110:Polymorphism, Genetic
D015415:Biomarkers; D015386:Hazardous Substances; D003577:Cytochrome P-450 Enzyme System