title: [Chromatin-protective action of the biologically active preparation BTK-8L in tetrachloromethane and chlorophos poisoning].
abstract: Results obtained from the study of the interaction between the phytosteroid preparation (BTK-8L) and fractionated rat liver nuclear chromatin under conditions of the tetrachloromethane and chlorophos intoxications are described. It is shown that preventive injection of BTK-8L to the animals has a partial protective effect on transcriptionally active and repressed liver chromatin. This preparation interacts with chromatin histone proteins binding with them and changes the nucleoprotein complex structure as a results of which the chromatin fraction components become less accessible to the damaging action of tetrachloromethane and chlorophos. The BTK-8L protective effect is exhibited on the DNA replication and transcriptional levels under conditions of tetrachloromethane and chlorophos intoxications.
authors.forename: E L
authors.initials: EL
authors.lastname: Levitskiĭ
authors.forename: Iu I
authors.initials: IuI
authors.lastname: Gubskiĭ
authors.forename: R G
authors.initials: RG
authors.lastname: Primak
authors.forename: A G
authors.initials: AG
authors.lastname: Goriushko
authors.forename: Iu D
authors.initials: IuD
authors.lastname: Kholodova
authors.forename: I E
authors.initials: IE
authors.lastname: Vistunova
authors.forename: A N
authors.initials: AN
authors.lastname: Marchenko
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D002252:Carbon Tetrachloride Poisoning / Q000188:drug therapy*; D002843:Chromatin / Q000187:drug effects*; D002868:Chromosomal Proteins, Non-Histone / Q000187:drug effects; D004247:DNA / Q000187:drug effects; D004996:Ethidium; D005456:Fluorescent Dyes; D006657:Histones / Q000187:drug effects; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013256:Steroids / Q000627:therapeutic use*; D014158:Transcription, Genetic / Q000187:drug effects; D014236:Trichlorfon / Q000506:poisoning*
chemical_list: D000975:Antioxidants; C088577:BTK 8L preparation; D002843:Chromatin; D002868:Chromosomal Proteins, Non-Histone; D005456:Fluorescent Dyes; D006657:Histones; D013256:Steroids; D004247:DNA; D014236:Trichlorfon; D004996:Ethidium
vernacular_title: Zashchitnoe po otnosheniiu k khromatinu deĭstvie biologicheski aktivnogo kompleksa BTK-8L v usloviiakh intoksikatsii tetrakhlormetanom i khlorofosom.