[The mechanism of the occurrence of vomiting during the primary reaction after exposure of the body to ionizing radiations at large doses].
In the experiments of dogs exposed to ionizing radiations at doses of 50 and 70 Gy, an essential role of the central mechanism in the origin of early postradiation vomiting has been confirmed. Insufficient efficiency of dimethpramide, a dophamynolytics, in this case may be connected either with initiation of other (non-dophamynosensitive) structures of the chemoreceptor trigger zone of with a growing role of the reflex way of vomiting arising due to a considerable intestinal injury that causes diarrhea. The inhibition of intestinal M-cholinoreceptors by methacine prevented diarrhea but didn't change the intensity of the vomiting reaction which, however, does not eliminate the possibility of afferentation from receptors that respond to others biologically active substances.
Martirosov
K S
KS
Grigor'ev
Iu G
IuG
Zorin
V V
VV
Norkin
I M
IM
D000208:Acute Disease; D000818:Animals; D000932:Antiemetics / Q000627:therapeutic use; D001549:Benzamides / Q000627:therapeutic use; D001561:Benzilates / Q000627:therapeutic use; D002794:Choline / Q000031:analogs & derivatives / Q000627:therapeutic use; D018680:Cholinergic Antagonists / Q000627:therapeutic use; D004285:Dogs; D018492:Dopamine Antagonists / Q000627:therapeutic use; D004307:Dose-Response Relationship, Radiation; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D004583:Electrons / Q000009:adverse effects; D005260:Female; D008297:Male; D010315:Particle Accelerators; D011833:Radiation Injuries, Experimental / Q000150:complications* / Q000188:drug therapy; D011897:Random Allocation; D013997:Time Factors; D014839:Vomiting / Q000209:etiology* / Q000517:prevention & control; D014916:Whole-Body Irradiation / Q000009:adverse effects*
D000932:Antiemetics; D001549:Benzamides; D001561:Benzilates; D018680:Cholinergic Antagonists; D018492:Dopamine Antagonists; C053908:metacine; C037141:dimetpramid; D002794:Choline
O mekhanizme vozniknoveniia rvoty v periode pervichnoĭ reaktsii posle vozdeĭstviia na organizm ioniziruiushchakh izlucheniĭ v bol'shakh dozakh.