title: Phosphoinositide 3-kinases: a conserved family of signal transducers.
abstract: Phosphoinositide 3-kinases (PI3Ks) generate lipids that are implicated in receptor-stimulated signalling and in the regulation of membrane traffic. Several distinct classes of PI3Ks have now been identified that have been conserved throughout eukaryotic evolution. Potential signalling pathways downstream of PI3Ks have been elucidated and PI3K function is now being characterised in several model organisms.
authors.affiliation: Ludwig Institute for Cancer Research, London, UK.
authors.forename: B
authors.initials: B
authors.lastname: Vanhaesebroeck
authors.forename: S J
authors.initials: SJ
authors.lastname: Leevers
authors.forename: G
authors.initials: G
authors.lastname: Panayotou
authors.forename: M D
authors.initials: MD
authors.lastname: Waterfield
mesh_terms: D000818:Animals; D017173:Caenorhabditis elegans / Q000201:enzymology; D004023:Dictyostelium / Q000201:enzymology; D004331:Drosophila melanogaster / Q000201:enzymology; D008563:Membrane Lipids / Q000378:metabolism; D008969:Molecular Sequence Data; D019869:Phosphatidylinositol 3-Kinases; D017853:Phosphotransferases (Alcohol Group Acceptor) / Q000737:chemistry / Q000145:classification / Q000378:metabolism; D015398:Signal Transduction; D013379:Substrate Specificity
chemical_list: D008563:Membrane Lipids; D019869:Phosphatidylinositol 3-Kinases; D017853:Phosphotransferases (Alcohol Group Acceptor)