[Anti-cataract activity of a vitamin E analog].
Anti-cataract activity of vitamin E analog with shortened side chain--2'-4'-methyl-pentenyl-acetoxy-2,5,7-tetramethylchroman has been studied. It is shown on the model system that the analog of vitamin E inhibits the increase of the lens agent fluorescence under irradiation of its homogenates by polychrome light. Taking no negative effect on the lens capsule epithelium, the drug normalizes the content of vitamin E in the blood and increases activity of Na+, K+, ATPase in the cortex and capsule of rabbits lenses in dynamics under simulation of light cataract in vivo.
Metelitsyna
I P
IP
Kuz'menko
I V
IV
Drozhzhina
G I
GI
Mal'tsev
E V
EV
Leus
N F
NF
Donchenko
G V
GV
D000818:Animals; D002386:Cataract / Q000378:metabolism / Q000517:prevention & control*; D002839:Chromans / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D005453:Fluorescence; D007908:Lens, Crystalline / Q000187:drug effects* / Q000378:metabolism; D011817:Rabbits; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism
C106778:2',4'-methyl-3'-pentenyl-6-acetoxy-2,5,7,8-tetramethylchroman; D002839:Chromans; D000254:Sodium-Potassium-Exchanging ATPase
Antikataraktal'naia aktivnost' analoga vitamina E.