title: Treatment of pain in chronic bowel subobstruction with self-administration of methadone.
abstract: Chronic treatment with opioids in cancer patients with chronic intestinal obstruction is hazardous, as uncontrolled constipation may result in definitive bowel obstruction. Intermittent use of opioids adjusted for fluctuating pain levels may enable patients to take the lowest opioid doses that will have sufficient effect, with a consequently lower risk of intestinal side effects. Methadone has many pharmacokinetic characteristics that fit it for use in this clinical situation. In two patients with recurrent episodes of bowel obstruction, methadone used at low doses and at flexible intervals regulated by the patients according to their pain level avoided the occurrence of new episodes of intestinal obstruction. Oral patient-controlled analgesia with methadone may be a simple, safe and cheap method of treating patients with pain associated with subtotal intestinal obstruction.
authors.affiliation: Pain Relief and Palliative Care Unit, SAMOT, Palermo, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Mercadante
authors.forename: M
authors.initials: M
authors.lastname: Sapio
authors.forename: R
authors.initials: R
authors.lastname: Serretta
mesh_terms: D000328:Adult; D016058:Analgesia, Patient-Controlled; D000701:Analgesics, Opioid / Q000008:administration & dosage* / Q000009:adverse effects; D001943:Breast Neoplasms / Q000150:complications; D002908:Chronic Disease; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007415:Intestinal Obstruction / Q000139:chemically induced / Q000517:prevention & control*; D008691:Methadone / Q000008:administration & dosage* / Q000009:adverse effects; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000150:complications; D010148:Intractable Pain / Q000188:drug therapy*
chemical_list: D000701:Analgesics, Opioid; D008691:Methadone