title: [Basic principles and possible variations in combination antihypertensive therapy].
abstract: The drug monotherapy of hypertension is successful in about half of the patients. The occurrence of relevant side-effects usually leads to a new treatment with an antihypertensive drug of another substance category (= sequential monotherapy). However, if normotension is not achieved despite good tolerance, the physician should combine two antihypertensive drugs with different modes of action. Similar to the monotherapy, a treatment procedure individually balanced to the patient-situation of the circulation, risk factors or coexisting diseases -determines success or failure. In the following, useful and clinically reliable combination options with first-line substance categories are described. Under the aspects of economy, pragmatism, and patient compliance, among other things it is dealt with reliable as well as new fixed combination preparations.
authors.affiliation: Medizinische Universitätspoliklinik/Ambulante Spezialmedizin, Berlin.
authors.forename: J
authors.initials: J
authors.lastname: Scholze
mesh_terms: D000959:Antihypertensive Agents / Q000008:administration & dosage* / Q000009:adverse effects; D004359:Drug Therapy, Combination; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000209:etiology; D016896:Treatment Outcome
chemical_list: D000959:Antihypertensive Agents
vernacular_title: Grundsätze und Variationsmöglichkeiten in der antihypertensiven Kombinationstherapie.