title: Gains in bone mineral density with resolution of vitamin D intoxication.
abstract: BACKGROUND
  Vitamin D intoxication is associated with the mobilization of skeletal calcium.
  
  
  OBJECTIVE
  To ascertain how the resolution of vitamin D intoxication affects bone density.
  
  
  METHODS
  Case series.
  
  
  METHODS
  Referral service for metabolic bone disease in a tertiary care teaching hospital.
  
  
  METHODS
  Four patients with osteoporosis who were each using several nonprescription dietary supplements and were found to have fasting hypercalciuria.
  
  
  METHODS
  Discontinuation of use of dietary supplements.
  
  
  METHODS
  Serial measurement of serum levels of 25-hydroxyvitamin D, ratio of fasting urinary calcium to creatinine, and bone mineral density for 3 years.
  
  
  RESULTS
  Discontinuation of use of dietary supplements resulted in the normalization of serum levels of 25-hydroxyvitamin D, the normalization of the ratio of urinary calcium to creatinine, and a mean annual increase in bone mineral density (+/- SD) of 1.9% +/- 0.5%.
  
  
  CONCLUSIONS
  Occult vitamin D intoxication was detected in patients who were using dietary supplements that contained an unadvertised high level of vitamin D. Resolution of vitamin D intoxication was associated with a rebound in bone mineral density.
authors.affiliation: Cedars-Sinal Medical Center, Los Angeles, California, USA.
authors.forename: J S
authors.initials: JS
authors.lastname: Adams
authors.forename: G
authors.initials: G
authors.lastname: Lee
mesh_terms: D000328:Adult; D000368:Aged; D015519:Bone Density / Q000187:drug effects*; D002118:Calcium / Q000652:urine; D003404:Creatinine / Q000652:urine; D005260:Female; D005527:Food, Fortified / Q000506:poisoning*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis / Q000139:chemically induced* / Q000378:metabolism; D014807:Vitamin D / Q000031:analogs & derivatives / Q000097:blood / Q000506:poisoning*
chemical_list: D014807:Vitamin D; C104450:25-hydroxyvitamin D; D003404:Creatinine; D002118:Calcium