title: Echocardiographic detection of pulmonary embolism in transit: implications for institution of thrombolytic therapy.
abstract: Right atrial or ventricular thrombi in patients with pulmonary embolism are emboli in transit and are a medical emergency because they are associated with a high mortality rate when treated conservatively with anticoagulation. The current standard therapy is less well accepted because of the risk of clot fragmentation and distal embolization. A case in which an unsuspected right ventricular thrombus was diagnosed by echocardiography is reported. This findings led to treatment with streptokinase (250,000 U, followed by 100,000 U/h for 24 h). Clinical improvement was rapidly obtained and the thrombus disappeared 10 h after the initial study. There was no complication. The case illustrates the utility of two-dimensional enchocardiography in the evaluation of patients with pulmonary embolic disease and the efficacy and safety of thrombolytic therapy in the treatment of pulmonary embolism in transit.
authors.affiliation: Division of Cardiology, Royal Victoria Hospital, McGill University, Montreal, Quebec.
authors.forename: D N
authors.initials: DN
authors.lastname: Fisman
authors.forename: I D
authors.initials: ID
authors.lastname: Malcolm
authors.forename: M E
authors.initials: ME
authors.lastname: Ward
mesh_terms: D004452:Echocardiography; D005260:Female; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D006352:Heart Ventricles / Q000000981:diagnostic imaging; D006801:Humans; D008875:Middle Aged; D011655:Pulmonary Embolism / Q000000981:diagnostic imaging* / Q000188:drug therapy*; D013300:Streptokinase / Q000627:therapeutic use*; D015912:Thrombolytic Therapy
chemical_list: D005343:Fibrinolytic Agents; D013300:Streptokinase