Laser Doppler skin blood flow and sympathetic nervous responses to surgical incision during halothane and isoflurane anesthesia.
The aim of the present study was to evaluate whether a sudden decrease in skin blood flow measured using a laser Doppler velocimeter reflects sympathetic nervous response to surgical skin incision during halothane (n = 17) and isoflurane (n = 16) anesthesia in 33 ASA physical status I or II patients scheduled for laparotomy. Plasma norepinephrine concentrations in the responding patients who showed a sudden decrease in the skin blood flow after surgical incision increased significantly and continued to increase 1-10 min after skin incision under halothane and isoflurane anesthesia. Although plasma norepinephrine concentrations in the nonresponders did not increase after surgical incision with halothane, the concentrations increased significantly at 1 min, but not at 3 and 10 min, after skin incision with isoflurane. The results indicate that the sudden decrease in laser Doppler flow reflects the sympathetic response to surgical incision. However, these also suggest that the factors that control the skin blood flow may not be simply sympathetic but may reflect other modulators as well. Plasma epinephrine concentration increased during skin incision, but the concentrations did not differ between the patients with and without a sudden decrease in skin blood flow. Increases in systolic blood pressure and rate-pressure product on skin incision were also significantly more in patients with skin blood flow response compared with those without the response. The magnitude of changes in plasma norepinephrine concentration and hemodynamic variables with skin incision was greater with isoflurane than with halothane at the same minimum alveolar anesthetic concentration level.
Mashimo
T
T
Department of Anesthesiology, Osaka University Medical School, Suita City, Japan.
Zhang
P
P
Kamibayashi
T
T
Inagaki
Y
Y
Ohara
A
A
Yamatodani
A
A
Yoshiya
I
I
D000328:Adult; D000368:Aged; D000769:Anesthesia, Inhalation; D018685:Anesthetics, Inhalation / Q000008:administration & dosage* / Q000493:pharmacokinetics; D001794:Blood Pressure / Q000187:drug effects; D062109:Dermatologic Surgical Procedures; D004837:Epinephrine / Q000097:blood; D005260:Female; D006221:Halothane / Q000008:administration & dosage* / Q000493:pharmacokinetics; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007530:Isoflurane / Q000008:administration & dosage* / Q000493:pharmacokinetics; D007813:Laparotomy; D017078:Laser-Doppler Flowmetry; D008297:Male; D008875:Middle Aged; D009638:Norepinephrine / Q000097:blood; D011650:Pulmonary Alveoli / Q000378:metabolism; D012039:Regional Blood Flow / Q000187:drug effects; D012867:Skin / Q000098:blood supply* / Q000187:drug effects / Q000294:innervation; D013564:Sympathetic Nervous System / Q000187:drug effects / Q000502:physiology*; D013566:Sympathomimetics / Q000097:blood; D013599:Systole; D014662:Vasoconstrictor Agents / Q000097:blood
D018685:Anesthetics, Inhalation; D013566:Sympathomimetics; D014662:Vasoconstrictor Agents; D007530:Isoflurane; D006221:Halothane; D009638:Norepinephrine; D004837:Epinephrine