title: Primary afferent-evoked synaptic plasticity in deep dorsal horn neurons from neonatal rat spinal cord in vitro.
abstract: Whole-cell patch clamp recordings of deep dorsal horn neurons were undertaken in 'thick' transverse slices to demonstrate plasticity of primary afferent-evoked synaptic responses following conditioning stimulation. Synaptic plasticity was observed in neurons throughout the age range examined (postnatal days 3-6 and 9-16) but only long-term depression (LTD) was evocable in older animals (P9-16). Both short- and long-latency synaptic responses could undergo long-term potentiation (LTP) and LTD suggesting that AMPA/kainate and NMDA receptor-evoked responses are modifiable.
authors.affiliation: Department of Physiology, University of Manitoba, Winnipeg, Canada.
authors.forename: S M
authors.initials: SM
authors.lastname: Garraway
authors.forename: S
authors.initials: S
authors.lastname: Pockett
authors.forename: S
authors.initials: S
authors.lastname: Hochman
mesh_terms: D000344:Afferent Pathways / Q000502:physiology; D000375:Aging / Q000502:physiology*; D000818:Animals; D000831:Animals, Newborn; D066298:In Vitro Techniques; D017774:Long-Term Potentiation; D009473:Neuronal Plasticity; D051381:Rats; D017207:Rats, Sprague-Dawley; D013116:Spinal Cord / Q000254:growth & development / Q000502:physiology*; D013126:Spinal Nerve Roots / Q000254:growth & development / Q000502:physiology*; D013569:Synapses / Q000502:physiology*; D013997:Time Factors