title: [Subclasses of IgG in patients with neurosyphilis].
abstract: IgG subclasses levels in the CSF and sera were measured in 15 patients with neurosyphilis. Intrathecal IgG and IgG subclasses synthesis was studied as well. There was an elevation of IgG1 and IgG3 subclasses in the CSF and IgG1 elevation in the sera of patients with neurosyphilis. General IgG index was elevated in 46% of the patients. This was due mainly to IgG1 and IgG3 intrathecal synthesis. Oligoclonal IgG bands were present in the CSF in seven out of 15 studied patients. These results may be helpful in the first stage of the diagnostic procedure before specific serological tests are performed.
authors.affiliation: Katedry i Kliniki Neurologii AM w Poznaniu.
authors.forename: J
authors.initials: J
authors.lastname: Losy
authors.forename: M
authors.initials: M
authors.lastname: Wender
mesh_terms: D000328:Adult; D000368:Aged; D002555:Cerebrospinal Fluid / Q000276:immunology; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000096:biosynthesis / Q000145:classification*; D008297:Male; D008875:Middle Aged; D009494:Neurosyphilis / Q000097:blood / Q000134:cerebrospinal fluid / Q000276:immunology*
chemical_list: D007074:Immunoglobulin G
vernacular_title: Podklasy IgG u pacjentów z kiła układu nerwowego.