New anti-HIV-1, antimalarial, and antifungal compounds from Terminalia bellerica.
A bioactivity-guided fractionation of an extract of Terminalia bellerica fruit rind led to the isolation of two new lignans named termilignan (1) and thannilignan (2), together with 7-hydroxy-3',4'-(methylenedioxy)flavan (3) and anolignan B (4). All four compounds possessed demonstrable anti-HIV-1, antimalarial, and antifungal activity in vitro.
Valsaraj
R
R
Division of Ethnopharmacology, Tropical Botanic Garden and Research Institute, Kerala, India.
Pushpangadan
P
P
Smitt
U W
UW
Adsersen
A
A
Christensen
S B
SB
Sittie
A
A
Nyman
U
U
Nielsen
C
C
Olsen
C E
CE
D019380:Anti-HIV Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification; D009682:Magnetic Resonance Spectroscopy; D010946:Plants, Medicinal / Q000737:chemistry*
C107721:7-hydroxy-3',4'-(methylenedioxy)flavan; D019380:Anti-HIV Agents; D000935:Antifungal Agents; D000962:Antimalarials; D005419:Flavonoids; D017705:Lignans