Clonal chromosome aberrations with monosomy of chromosome 8 in a case of grade III chondrosarcoma.
We report cytogenetic findings in a case of grade III chondrosarcoma. Complex clonal chromosome aberrations including monosomy of chromosomes 4, 8, 13, and a consistent t(5;14)(q23;p12) were observed in all cells. There were no structural or numerical anomalies involving chromosome 12. The complexity of the chromosome aberrations reflect the advanced stage of this chondrosarcoma; we suggest a possible involvement of the EXT1 gene located on chromosome 8.
Ptaszynski
K
K
Department of Pathology, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, New York 10461, USA.
Ramesh
K H
KH
Cannizzaro
L A
LA
D000368:Aged; D002813:Chondrosarcoma / Q000235:genetics* / Q000473:pathology; D002869:Chromosome Aberrations; D005260:Female; D005266:Femoral Neoplasms / Q000235:genetics* / Q000473:pathology; D006801:Humans; D007621:Karyotyping; D009006:Monosomy; D009364:Neoplasm Recurrence, Local; D014178:Translocation, Genetic