The influence of ischemic bowel wall damage on translocation, inflammatory response, and clinical course.
BACKGROUND
While vascular patency and overall viability of the gut can be evaluated perioperatively, damage to the mucosal barrier can hardly be judged in the perioperative setting and, moreover, will probably determine the clinical course.


METHODS
In 19 consecutive cases with intestinal ischemia, the clinical course was correlated to the severity of the disease (APACHE II; Septic Severity Score, SSS), the intraabdominal and systemic inflammatory response, and the translocation of bacteria and endotoxin.


RESULTS
The comparison of the 10 survivors with the nonsurviving group revealed no differences as to the length of history, serum lactate levels, white blood cell counts, body temperature, markers of the inflammatory response, or quantity and macroscopic quality of the exudate. Differences were found in intraperitoneal bacteriology (prevalence 0.37, negative predictive value for lethal outcome 0.8), endotoxin concentrations in the exudate (P = 0.02) and in the plasma (P = 0.015), fibrinopeptide A levels (exudate P = 0.036; plasma P = 0.015), PGE2 plasma concentration (P = 0.0357), and APACHE II (P = 0.0034) and SSS (P = 0.0027) values.


CONCLUSIONS
The clinical course of ischemic bowel wall necrosis seems to depend on the severity of the disease at admission and on the integrity of the mucosal barrier rather than on inflammatory response, therapeutic measures, or supportive treatment.
Schoeffel
U
U
Department of Surgery, University of Freiburg, Germany.
Baumgartner
U
U
Imdahl
A
A
Haering
R
R
v Specht
B U
BU
Farthmann
E H
EH
D018806:APACHE; D000368:Aged; D001831:Body Temperature; D015232:Dinoprostone / Q000097:blood; D004731:Endotoxins / Q000378:metabolism; D005260:Female; D005344:Fibrinopeptide A / Q000378:metabolism; D006801:Humans; D007422:Intestines / Q000098:blood supply*; D007511:Ischemia / Q000378:metabolism / Q000382:microbiology / Q000503:physiopathology*; D007773:Lactates / Q000097:blood; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index
D004731:Endotoxins; D007773:Lactates; D005344:Fibrinopeptide A; D015232:Dinoprostone