[HPLC analysis of non-steroidal antirheumatic agents in biological material. II. Profens].
The present paper surveys the published HPLC methods evaluating profens in biological materials and reports a HPLC method for the determination of ibuprofen in the samples of whole blood. For liquid-liquid extraction, ibuprofen was analyzed on the reverse phases Separon SGX C18 with the mobile phase methanol-water (pH 3.0) and detected at 222 nm. The elaborated method was employed in a pharmacokinetic study of ibuprofen on laboratory rabbits.
Sochor
J
J
Katedra farmaceutické chemie a kontroly léciv Farmaceutické fakulty Univerzity Karlovy, Hradec Králové.
Klimes
J
J
Sedlácek
J
J
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000097:blood* / Q000493:pharmacokinetics; D002851:Chromatography, High Pressure Liquid; D007052:Ibuprofen / Q000097:blood* / Q000493:pharmacokinetics; D007213:Indomethacin / Q000097:blood / Q000493:pharmacokinetics; D011817:Rabbits
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007052:Ibuprofen; D007213:Indomethacin
HPLC analýza nesteroidních antirevmatik v biologickém materiálu II. Profeny.