title: Plasmacytoma of the eye and orbit.
abstract: BACKGROUND
  Plasmacytomas of the ocular and adnexal tissue are rare. The variation in their clinical manifestations and potential association with multiple myeloma are not well appreciated.
  
  
  METHODS
  We reviewed the clinical features and laboratory data of five cases of plasmacytoma involving the eye and orbit.
  
  
  RESULTS
  Plasmacytomas involved the conjunctiva in one case, the orbit in three cases, and the iris in one case. Plasmacytoma was the solitary plasma cell neoplasm in a patient with a conjunctival lesion and another patient with an orbital lesion. Two other patients who developed plasmacytomas of the orbit and iris, respectively, had a known history of multiple myeloma. An orbital plasmacytoma preceded the onset of systemic plasma cell neoplasia in the final patient.
  
  
  CONCLUSIONS
  Plasmacytomas of the eye and orbit are rare. They may or may not be associated with multiple myeloma.
authors.affiliation: Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA, USA.
authors.forename: J W
authors.initials: JW
authors.lastname: Adkins
authors.forename: J A
authors.initials: JA
authors.lastname: Shields
authors.forename: C L
authors.initials: CL
authors.lastname: Shields
authors.forename: R C
authors.initials: RC
authors.lastname: Eagle
authors.forename: J C
authors.initials: JC
authors.lastname: Flanagan
authors.forename: P C
authors.initials: PC
authors.lastname: Campanella
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003131:Combined Modality Therapy; D003230:Conjunctival Neoplasms / Q000473:pathology* / Q000628:therapy; D005260:Female; D006801:Humans; D015811:Iris Neoplasms / Q000473:pathology* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009918:Orbital Neoplasms / Q000473:pathology* / Q000628:therapy; D010954:Plasmacytoma / Q000473:pathology* / Q000628:therapy; D014057:Tomography, X-Ray Computed