[The effect of the new angiotensin-converting enzyme inhibitor moexipril on the circadian rhythms of arterial pressure in hypertension patients].
24-hour monitoring of arterial pressure was performed before, 3 and 9 weeks after moexipril treatment (daily dose 7.5-15 mg) for mild and moderate hypertension. Of 15 patients treated 66.6% responded to the 9-week course. Adjuvant hypothiazid elevated the effect to 73.6%. Moexipril lowered mean 24-h diastolic pressure without changing the 24-h pressure curve or heart rate. Antihypertensive moexipril effect was higher in the day time. Variability of diastolic arterial pressure was lower at night.
Ol'binskaia
L I
LI
Andrushchishina
T B
TB
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000009:adverse effects / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects*; D002940:Circadian Rhythm / Q000187:drug effects*; D003692:Delayed-Action Preparations; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D007546:Isoquinolines / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D011355:Prodrugs / Q000009:adverse effects / Q000627:therapeutic use*; D044005:Tetrahydroisoquinolines; D013997:Time Factors
D000806:Angiotensin-Converting Enzyme Inhibitors; D003692:Delayed-Action Preparations; D007546:Isoquinolines; D011355:Prodrugs; D044005:Tetrahydroisoquinolines; C058302:moexipril
Vliianie novogo ingibitora angiotenzinprevrashchaiushchego fermenta moéksiprila na sutochnye ritmy arterial'nogo davleniia u bol'nykh gipertonicheskoĭ bolezn'iu.