title: The detection and consequences of anxiety in clinical depression.
abstract: Anxiety symptoms and comorbid anxiety are common in depressive syndromes, and there is evidence they are associated with increased severity of depression and a poorer outcome. Anxiety and agitation symptoms also appear to be an acute risk factor for suicide in patients who have major affective disorder, an observation that has been supported by a number of biological correlates. Rapid and aggressive treatment of these anxiety/agitation symptoms with suitable antidepressants or benzodiazepines should be considered in order to avoid the immediate risk of suicide and to permit successful treatment of the affective disorder.
authors.affiliation: Department of Psychiatry, Rush-Presbyterian-St. Luke's Medical Centre, Chicago, IL 60612-3824, USA.
authors.forename: J
authors.initials: J
authors.lastname: Fawcett
mesh_terms: D000328:Adult; D000929:Antidepressive Agents, Tricyclic / Q000009:adverse effects / Q000627:therapeutic use; D001008:Anxiety Disorders / Q000175:diagnosis* / Q000453:epidemiology / Q000523:psychology; D001569:Benzodiazepines / Q000627:therapeutic use; D015897:Comorbidity; D003866:Depressive Disorder / Q000175:diagnosis* / Q000453:epidemiology / Q000523:psychology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011595:Psychomotor Agitation / Q000523:psychology; D012307:Risk Factors; D012720:Severity of Illness Index; D013405:Suicide / Q000523:psychology / Q000706:statistics & numerical data; D000092864:Suicide Prevention
chemical_list: D000929:Antidepressive Agents, Tricyclic; D001569:Benzodiazepines