Functional role of CD40 and its ligand.
CD40, a cell surface receptor which belongs to the TNF-R family, was first identified and functionally characterized on B lymphocytes. In recent years, CD40 has been found expressed on other cells, including monocytes, dendritic cells, endothelial cells and epithelial cells and is now thought to play a more general role in immune regulation. The present paper reviews recent developments about CD40, with main emphasis on: (1) structure and expression of CD40 and its ligand; (2) CD40 signal transduction; (3) in vitro function of CD40 on different cell types, and (4) in vivo functions of CD40/CD40L interactions.
van Kooten
C
C
Department of Nephrology, Leiden University Hospital, The Netherlands.
Banchereau
J
J
D000917:Antibody Formation; D015551:Autoimmunity; D001402:B-Lymphocytes / Q000276:immunology / Q000378:metabolism; D019013:CD40 Antigens / Q000276:immunology / Q000378:metabolism / Q000502:physiology*; D023201:CD40 Ligand; D003141:Communicable Diseases / Q000276:immunology; D003713:Dendritic Cells / Q000276:immunology / Q000378:metabolism; D004727:Endothelium / Q000166:cytology / Q000276:immunology; D004847:Epithelial Cells; D004848:Epithelium / Q000276:immunology; D005347:Fibroblasts / Q000276:immunology / Q000378:metabolism; D006801:Humans; D008562:Membrane Glycoproteins / Q000276:immunology / Q000502:physiology*; D009000:Monocytes / Q000276:immunology / Q000378:metabolism; D015398:Signal Transduction / Q000276:immunology
D019013:CD40 Antigens; D008562:Membrane Glycoproteins; D023201:CD40 Ligand