title: Lansoprazole versus omeprazole in the treatment of reflux esophagitis.
abstract: To evaluate the therapeutic potential of the newly developed proton pump inhibitor lansoprazole in patients with reflux esophagitis (grade I and II according to Savary Müller criteria), the authors performed a single blind, randomized clinical trial comparing 20 mg omeprazole and 30 mg lansoprazole, involving 60 patients at two clinical hospitals. The treatment period was or 8 weeks, and main efficacy variables were healing of endoscopic changes and relief of reflux symptoms. No significant difference in terms of healing and relief of reflux symptoms was found either after 4 or after 8 weeks of treatment. In conclusion, 30 mg lansoprazole daily was found to be safe and effective therapy comparable to omeprazole in the short-term treatment for reflux esophagitis (grade I and II).
authors.affiliation: Department of Medicine, Osijek University Hospital, Croatia.
authors.forename: A
authors.initials: A
authors.lastname: Vcev
authors.forename: D
authors.initials: D
authors.lastname: Stimac
authors.forename: A
authors.initials: A
authors.lastname: Vceva
authors.forename: M
authors.initials: M
authors.lastname: Rubinić
authors.forename: A
authors.initials: A
authors.lastname: Ivandić
authors.forename: N
authors.initials: N
authors.lastname: Ivanis
authors.forename: D
authors.initials: D
authors.lastname: Horvat
authors.forename: M
authors.initials: M
authors.lastname: Volarić
authors.forename: I
authors.initials: I
authors.lastname: Karner
mesh_terms: D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D000897:Anti-Ulcer Agents / Q000009:adverse effects / Q000627:therapeutic use*; D004942:Esophagitis, Peptic / Q000188:drug therapy*; D005260:Female; D006801:Humans; D064747:Lansoprazole; D008297:Male; D008875:Middle Aged; D009853:Omeprazole / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D016037:Single-Blind Method
chemical_list: D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D000897:Anti-Ulcer Agents; D064747:Lansoprazole; D009853:Omeprazole