title: 3,6-Disubstituted 1,2,4-triazolo[3,4-b][1,3,4]thiadiazoles: synthesis and evaluation for antimicrobial and antiviral activity. III.
abstract: A series of novel 3,6-disubstituted 1,2,4-triazolo[3,4-b][1,3,4]thiadiazole derivatives was prepared and tested to evaluate their antimycotic, antibacterial and anti-HIV-1 activities. The reaction of thiocarbohydrazide with carboxylic acids at the melting temperature allows an improved preparation of the 5-substituted 4-amino-3-mercapto-1,2,4-triazole heterocycles which in turn allows an easier preparation of the 1,2,4-triazolo[3,4-b] [1,3,4]thiadiazole ring system. All tested compounds didn't show any significant activity.
authors.affiliation: Istituto Farmacochimico dell'Università di Palermo, Italy.
authors.forename: F P
authors.initials: FP
authors.lastname: Invidiata
authors.forename: G
authors.initials: G
authors.lastname: Furnò
authors.forename: D
authors.initials: D
authors.lastname: Simoni
authors.forename: I
authors.initials: I
authors.lastname: Lampronti
authors.forename: C
authors.initials: C
authors.lastname: Musiu
authors.forename: C
authors.initials: C
authors.lastname: Milia
authors.forename: F
authors.initials: F
authors.lastname: Scintu
authors.forename: P
authors.initials: P
authors.lastname: La Colla
mesh_terms: D019380:Anti-HIV Agents / Q000138:chemical synthesis / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002460:Cell Line; D004341:Drug Evaluation; D006801:Humans; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D013830:Thiadiazoles / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D019380:Anti-HIV Agents; D000890:Anti-Infective Agents; D000998:Antiviral Agents; D013830:Thiadiazoles