2,5-Diketopiperidine derivatives as non-peptide ligands for cholecystokinin receptors.
Easily accessible 2,5-diketopiperidines have been used as templates for the construction of Trp-Phe and Trp-Asp-Phe-NH2 mimics. The cycle [L-Trp psi[COCH2]-L-Phe] analogue 1a has shown to possess significant and selective affinity for CCKA receptors.
González-Muñiz
R G
RG
Instituto de Química Médica (C.S.I.C.), Madrid, Spain.
Domínguez
M J
MJ
Herranz
R
R
García-López
M T
MT
Ballaz
S J
SJ
Fortuño
A
A
Del Río
J
J
D008024:Ligands; D015394:Molecular Structure; D010455:Peptides; D010880:Piperidines / Q000737:chemistry / Q000378:metabolism*; D011949:Receptors, Cholecystokinin / Q000378:metabolism*
D008024:Ligands; D010455:Peptides; D010880:Piperidines; D011949:Receptors, Cholecystokinin