Defective antigen-induced lymphocyte proliferation in the X-linked hyper-IgM syndrome.
We examined T-cell proliferation in five patients with X-linked hyper-IgM syndrome (XHIM), using a panel of antigens and lectins. All patients had impaired antigen-induced proliferation, whereas their lectin responses were normal. Thus, in addition to severely depressed antibody responses, patients with XHIM have a defect in antigen-specific T-cell proliferation, which may explain their susceptibility to pathogens such as Pneumocystis carinii.
Ameratunga
R
R
Department of Molecular Medicine, University of Auckland, New Zealand.
Lederman
H M
HM
Sullivan
K E
KE
Ochs
H D
HD
Seyama
K
K
French
J K
JK
Prestidge
R
R
Marbrook
J
J
Fanslow
W C
WC
Winkelstein
J A
JA
D000941:Antigens / Q000276:immunology*; D000946:Antigens, Fungal; D019013:CD40 Antigens / Q000235:genetics; D002175:Candida / Q000276:immunology; D003208:Concanavalin A; D003457:Cryptosporidiosis / Q000276:immunology; D004168:Diphtheria Toxoid; D004198:Disease Susceptibility / Q000276:immunology; D008040:Genetic Linkage; D006801:Humans; D006942:Hypergammaglobulinemia / Q000235:genetics / Q000276:immunology*; D007075:Immunoglobulin M; D007153:Immunologic Deficiency Syndromes / Q000235:genetics / Q000276:immunology*; D037102:Lectins; D008024:Ligands; D008213:Lymphocyte Activation / Q000276:immunology*; D008297:Male; D010835:Phytohemagglutinins; D011020:Pneumonia, Pneumocystis / Q000276:immunology; D011043:Pokeweed Mitogens; D013601:T-Lymphocytes / Q000276:immunology*; D013745:Tetanus Toxoid; D014960:X Chromosome
D000941:Antigens; D000946:Antigens, Fungal; D019013:CD40 Antigens; D004168:Diphtheria Toxoid; D007075:Immunoglobulin M; D037102:Lectins; D008024:Ligands; D010835:Phytohemagglutinins; D011043:Pokeweed Mitogens; D013745:Tetanus Toxoid; D003208:Concanavalin A