title: Inhibitory effects of Korean folk medicine 'Hi-Chum' on histamine release from mast cells in vivo and in vitro.
abstract: The effect of aqueous extract of Siegesbeckia glabrescence (Compositae) whole plants (SGWP) on systemic or local anaphylaxis was studied. SGWP inhibited compound 48/80-induced systemic anaphylaxis 100% with a dose of 1000 mg/kg. Oral administration of SGWP (100 mg/kg) showed a marked inhibition rate in local immunoglobulin E (IgE)-mediated passive cutaneous anaphylaxis reaction. When SGWP was pretreated at concentration ranging from 0.1 to 1000 mg/kg, the serum histamine levels were reduced in a dose-dependent manner. Moreover, SGWP dose-dependently inhibited the histamine release from peritoneal mast cells by compound 48/80. These results indicate that SGWP possess strong antianaphylactic activity by inhibition of histamine release from mast cells.
authors.affiliation: Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University, Iksan, Chonbuk, South Korea.
authors.forename: B K
authors.initials: BK
authors.lastname: Kang
authors.forename: E H
authors.initials: EH
authors.lastname: Lee
authors.forename: H M
authors.initials: HM
authors.lastname: Kim
mesh_terms: D000707:Anaphylaxis / Q000517:prevention & control; D000818:Animals; D006634:Histamine H1 Antagonists / Q000494:pharmacology*; D006636:Histamine Release / Q000187:drug effects*; D007073:Immunoglobulin E / Q000276:immunology; D008407:Mast Cells / Q000187:drug effects* / Q000378:metabolism; D008519:Medicine, Traditional; D051379:Mice; D008807:Mice, Inbred BALB C; D010946:Plants, Medicinal; D051381:Rats; D017208:Rats, Wistar; D003189:p-Methoxy-N-methylphenethylamine / Q000494:pharmacology
chemical_list: D006634:Histamine H1 Antagonists; D007073:Immunoglobulin E; D003189:p-Methoxy-N-methylphenethylamine