Ibogaine interferes with the establishment of amphetamine place preference learning.
The ability of ibogaine, injected 24 hr before amphetamine, to modify the establishment of amphetamine-induced place preference learning was assessed. A single injection of ibogaine blocked the establishment of amphetamine place preference after 1 or 2 conditioning trials, but it was less effective after 4 trials. The reduced effectiveness of ibogaine across multiple conditioning trials appears to be the result of the development of tolerance to ibogaine.
Moroz
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Department of Psychology, Wilfrid Laurier University, Waterloo, Ontario, Canada.
Parker
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LA
Siegel
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S
D000661:Amphetamine / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D000818:Animals; D000697:Central Nervous System Stimulants / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D003216:Conditioning, Operant / Q000187:drug effects*; D004361:Drug Tolerance; D007050:Ibogaine / Q000494:pharmacology*; D008297:Male; D011619:Psychotropic Drugs / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley
D000697:Central Nervous System Stimulants; D011619:Psychotropic Drugs; D007050:Ibogaine; D000661:Amphetamine