title: Temperature during cardiopulmonary bypass for coronary artery operations does not influence postoperative cognitive function: a prospective, randomized trial.
abstract: OBJECTIVE
  The objective was to examine the effect of temperature (28 degrees vs 36 degrees C) during cardiopulmonary bypass on postoperative cognitive functions in a prospective, double-blind, and randomized manner.
  
  
  METHODS
  Sixty-two patients scheduled for coronary operations were randomized to warm or cold cardiopulmonary bypass. Preoperative and postoperative (7 days) neuropsychologic evaluations were performed by an observer unaware of cardiopulmonary bypass temperature.
  
  
  RESULTS
  Fifty-four patients completed the study (cold bypass, n = 24; warm bypass, n = 30). Significant (p < 0.01) postoperative deterioration for tests of psychomotor coordination and verbal memory was noted in both warm and cold groups, but no differences were observed between groups.
  
  
  CONCLUSIONS
  Temperature during cardiopulmonary bypass for coronary operations does not influence postoperative cognitive function.
authors.affiliation: Department of Anesthesia, Royal Victoria Hospital, Montreal, Quebec, Canada. mdgp@musica.mcgill.ca
authors.forename: G
authors.initials: G
authors.lastname: Plourde
authors.forename: A S
authors.initials: AS
authors.lastname: Leduc
authors.forename: J E
authors.initials: JE
authors.lastname: Morin
authors.forename: B
authors.initials: B
authors.lastname: DeVarennes
authors.forename: D
authors.initials: D
authors.lastname: Latter
authors.forename: J
authors.initials: J
authors.lastname: Symes
authors.forename: R
authors.initials: R
authors.lastname: Robbins
authors.forename: N
authors.initials: N
authors.lastname: Fosset
authors.forename: L
authors.initials: L
authors.lastname: Couture
authors.forename: A
authors.initials: A
authors.lastname: Ptito
mesh_terms: D000328:Adult; D000368:Aged; D002315:Cardiopulmonary Bypass / Q000009:adverse effects / Q000379:methods*; D003071:Cognition; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007036:Hypothermia, Induced; D008297:Male; D008569:Memory Disorders / Q000209:etiology*; D008875:Middle Aged; D009483:Neuropsychological Tests; D011183:Postoperative Complications / Q000209:etiology; D011446:Prospective Studies; D011596:Psychomotor Disorders / Q000209:etiology*; D013696:Temperature; D013997:Time Factors