First- and second-generation antisense inhibitors targeted to human c-raf kinase: in vitro and in vivo studies.
Monia
B P
BP
Department of Molecular Pharmacology, Isis Pharmaceuticals, Carlsbad, CA 92008, USA.
D000818:Animals; D001483:Base Sequence; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D006801:Humans; D016376:Oligonucleotides, Antisense / Q000494:pharmacology*; D017346:Protein Serine-Threonine Kinases / Q000037:antagonists & inhibitors*; D011518:Proto-Oncogene Proteins / Q000037:antagonists & inhibitors*; D019908:Proto-Oncogene Proteins c-raf; D012333:RNA, Messenger / Q000187:drug effects / Q000378:metabolism
D004791:Enzyme Inhibitors; D016376:Oligonucleotides, Antisense; D011518:Proto-Oncogene Proteins; D012333:RNA, Messenger; D017346:Protein Serine-Threonine Kinases; D019908:Proto-Oncogene Proteins c-raf