[Results of studies of regulatory mechanisms of hematopoiesis in health and disease].
Local and distant hemopoietic regulatory mechanisms were studied under various emergencies (immobilization, cytostatic injection, radiation, etc.). There were common processes (cell migration, destruction, T-lymphocyte accumulation, activation of the microenvironment and hemopoietic precursors) forming the local basis for compensatory and adaptive reactions of bone marrow hemopoietic tissue. Emphasis is laid on the association of local mechanisms with the neuroendocrine system which inevitably becomes activated under extreme exposures. On exposure to irritants having no myeloinhibitory effect, neurotransmitters and hormones, mainly glucocorticoids and catecholamines cause the development of erythro- and granulocytopoietic hyperplasia due to stimulation of the hemopoiesis-inducing microenvironment (HIM). Under hemopoiesis-suppressing influences, catecholamine-induced activations of HIM's resistant elements is accompanied by simultaneous inhibition of hemopoietic cells and HIN's factors damaged by an irritant. Under these conditions hemopoietic separation caused by the heterogeneous effect of transmitters on the cell leads to imbalance of hemopoietic precursor proliferation and differentiation and, finally, to delayed hemopoietic tissue regeneration. At the same time, the neuroendocrine system does not seem to play a leading role as compared to the control intact hemopoiesis.
Gol'dberg
E D
ED
Dygaĭ
A M
AM
Khlusov
I A
IA
D000970:Antineoplastic Agents / Q000494:pharmacology; D001854:Bone Marrow Cells; D002056:Burns / Q000503:physiopathology; D002395:Catecholamines / Q000494:pharmacology; D004920:Erythropoiesis / Q000187:drug effects / Q000502:physiology; D005938:Glucocorticoids / Q000494:pharmacology; D006410:Hematopoiesis / Q000187:drug effects / Q000502:physiology* / Q000528:radiation effects; D006801:Humans; D007509:Irritants / Q000494:pharmacology; D009490:Neurosecretory Systems / Q000502:physiology; D018377:Neurotransmitter Agents / Q000494:pharmacology; D012038:Regeneration; D013234:Stem Cells / Q000187:drug effects
D000970:Antineoplastic Agents; D002395:Catecholamines; D005938:Glucocorticoids; D007509:Irritants; D018377:Neurotransmitter Agents
Itogi izucheniia mekhanizmov reguliatsii krovetvoreniia v norme i pri patologii.