title: Paradoxic uptake of Gd-EOB-DTPA by hepatocellular carcinoma in mice: quantitative image analysis.
abstract: To determine whether paradoxic uptake of gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA) occurs only with highly differentiated hepatocellular carcinomas, quantitative image analysis was performed in 37 mice with 133 hepatocellular carcinomas. The results of lesion/ liver signal intensity measurement and relative enhancement calculation indicate that paradoxic positive enhancement occurs independently of cellular differentiation.
authors.affiliation: Department of Diagnostic Radiology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Fujita
authors.forename: R
authors.initials: R
authors.lastname: Yamamoto
authors.forename: M
authors.initials: M
authors.lastname: Takahashi
authors.forename: T
authors.initials: T
authors.lastname: Tsuji
authors.forename: T
authors.initials: T
authors.lastname: Yamanaka
authors.forename: T
authors.initials: T
authors.lastname: Miyazawa
authors.forename: B
authors.initials: B
authors.lastname: Fritz-Zieroth
authors.forename: N
authors.initials: N
authors.lastname: Terada
authors.forename: C
authors.initials: C
authors.lastname: Kuroda
mesh_terms: D000818:Animals; D003287:Contrast Media / Q000493:pharmacokinetics*; D005682:Gadolinium / Q000493:pharmacokinetics; D019786:Gadolinium DTPA; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008099:Liver / Q000473:pathology*; D008114:Liver Neoplasms, Experimental / Q000473:pathology*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009942:Organometallic Compounds / Q000493:pharmacokinetics; D004369:Pentetic Acid / Q000031:analogs & derivatives* / Q000493:pharmacokinetics
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; C073590:gadolinium ethoxybenzyl DTPA; D004369:Pentetic Acid; D005682:Gadolinium; D019786:Gadolinium DTPA