[New inhibitors of tumor angiogenesis].
During the past few years, our understanding of the molecular mechanisms of angiogenesis has steadily increased. These informations allowed the design of new strategies aimed to kill cancer cells by shutting off the blood vessels through which they get the oxygen and nutrients they need to grow. Therapies that target tumor blood vessels cause the regression of solid tumors in mice. The possibility to obtain synergistic effects by combining antiangiogenic and cytotoxic therapy, and the therapeutic applications of these studies will be discussed, following a meeting on angiogenesis held in Boston on February 10th and 11th 1997.
Mattot
V
V
CNRS EP 560, Institut Pasteur de Lille, France.
Vandenbunder
B
B
D000818:Animals; D016228:Endothelial Growth Factors / Q000037:antagonists & inhibitors; D006801:Humans; D008495:Medical Oncology / Q000639:trends*; D051379:Mice; D009361:Neoplasm Invasiveness / Q000517:prevention & control; D009362:Neoplasm Metastasis / Q000517:prevention & control; D009369:Neoplasms / Q000098:blood supply* / Q000628:therapy; D009389:Neovascularization, Pathologic / Q000503:physiopathology
D016228:Endothelial Growth Factors
De nouveaux outils pour bloquer l'angiogenèse tumorale.