3,6-Disubstituted 1,2,4-triazolo[3,4-b][1,3,4]thiadiazoles: synthesis and evaluation for antimicrobial and antiviral activity. III.
A series of novel 3,6-disubstituted 1,2,4-triazolo[3,4-b][1,3,4]thiadiazole derivatives was prepared and tested to evaluate their antimycotic, antibacterial and anti-HIV-1 activities. The reaction of thiocarbohydrazide with carboxylic acids at the melting temperature allows an improved preparation of the 5-substituted 4-amino-3-mercapto-1,2,4-triazole heterocycles which in turn allows an easier preparation of the 1,2,4-triazolo[3,4-b] [1,3,4]thiadiazole ring system. All tested compounds didn't show any significant activity.
Invidiata
F P
FP
Istituto Farmacochimico dell'Università di Palermo, Italy.
Furnò
G
G
Simoni
D
D
Lampronti
I
I
Musiu
C
C
Milia
C
C
Scintu
F
F
La Colla
P
P
D019380:Anti-HIV Agents / Q000138:chemical synthesis / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002460:Cell Line; D004341:Drug Evaluation; D006801:Humans; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D013830:Thiadiazoles / Q000138:chemical synthesis* / Q000494:pharmacology
D019380:Anti-HIV Agents; D000890:Anti-Infective Agents; D000998:Antiviral Agents; D013830:Thiadiazoles