title: Eighteen cases exposed to sarin in Matsumoto, Japan.
abstract: Forty-six patients who were exposed to sarin consulted our hospital because of darkness of vision, and ocular pain, vomiting, dyspnea and headaches on June 27 and 28, 1994. Eighteen patients were admitted and 4 of them were in the critical state. There were 6 features: 1) depression of plasma cholinesterase activity (17 of 18 patients, 94%), 2) hypokalemia (4/18, 22%), 3) depression of triglyceride (12/18, 67%), 4) hypocapnia (5/17, 29%), 5) partial pressure of oxygen (PaO2) <80 mmHg, or requirement of O2 inhalation (15/18, 83%), 6) white blood cells (WBC) >9,000 per mm3 (13/18, 72%). Seventeen patients were discharged from hospital, but one patient is still suffering from akinetic mutism after two years.
authors.affiliation: Department of Internal Medicine, Matsumoto Kyoritsu Hospital, Nagano.
authors.forename: J
authors.initials: J
authors.lastname: Suzuki
authors.forename: T
authors.initials: T
authors.lastname: Kohno
authors.forename: M
authors.initials: M
authors.lastname: Tsukagosi
authors.forename: T
authors.initials: T
authors.lastname: Furuhata
authors.forename: K
authors.initials: K
authors.lastname: Yamazaki
mesh_terms: D000328:Adult; D000405:Akinetic Mutism / Q000097:blood / Q000139:chemically induced*; D001281:Atrial Fibrillation / Q000097:blood / Q000139:chemically induced; D001772:Blood Cell Count / Q000187:drug effects; D001798:Blood Proteins / Q000187:drug effects; D002412:Cations / Q000097:blood; D002619:Chemical Warfare Agents / Q000494:pharmacology / Q000506:poisoning*; D002800:Cholinesterase Inhibitors / Q000494:pharmacology / Q000506:poisoning*; D002802:Cholinesterases / Q000097:blood / Q000172:deficiency; D003128:Coma / Q000097:blood / Q000139:chemically induced*; D004417:Dyspnea / Q000139:chemically induced; D005260:Female; D006261:Headache / Q000097:blood / Q000139:chemically induced; D006323:Heart Arrest / Q000097:blood / Q000139:chemically induced*; D006327:Heart Block / Q000097:blood / Q000139:chemically induced; D006464:Hemoperfusion; D006801:Humans; D007008:Hypokalemia / Q000097:blood / Q000139:chemically induced; D000860:Hypoxia / Q000097:blood / Q000139:chemically induced; D007564:Japan; D008875:Middle Aged; D018721:Muscarinic Agonists / Q000494:pharmacology / Q000506:poisoning; D018722:Nicotinic Agonists / Q000494:pharmacology / Q000506:poisoning; D010313:Partial Pressure; D011041:Poisoning / Q000628:therapy; D012524:Sarin / Q000494:pharmacology / Q000506:poisoning*; D014280:Triglycerides / Q000097:blood; D014754:Violence; D014786:Vision Disorders / Q000139:chemically induced; D014839:Vomiting / Q000139:chemically induced
chemical_list: D001798:Blood Proteins; D002412:Cations; D002619:Chemical Warfare Agents; D002800:Cholinesterase Inhibitors; D018721:Muscarinic Agonists; D018722:Nicotinic Agonists; D014280:Triglycerides; D012524:Sarin; D002802:Cholinesterases