High-resolution brain SPECT imaging in ADHD.
Children and adolescents with ADHD were evaluated with high-resolution brain SPECT imaging to determine if there were similarities between reported PET and QEEG findings. Fifty-four children and adolescents with ADHD by DSM-III-R and Conners Rating Scale criteria were evaluated. A non-ADHD control group was also studied with SPECT. Two brain SPECT studies were done on each group, a resting study and an intellectual stress study done while participants were doing a concentration task. Sixty-fiver percent of the ADHD group revealed decreased perfusion in the prefrontal cortex with intellectual stress, compared to only 5% of the control group. These are findings consistent with PET and QEEG findings. Of the ADHD group who did not show decreased perfusion, two-thirds had markedly decreased activity in the prefrontal cortices at rest.
Amen
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Amen Clinic for Behavioral Medicine, Fairfield, California 94585, USA.
Carmichael
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D000293:Adolescent; D001289:Attention Deficit Disorder with Hyperactivity / Q000000981:diagnostic imaging*; D001921:Brain / Q000000981:diagnostic imaging*; D002648:Child; D004569:Electroencephalography; D005260:Female; D006801:Humans; D008297:Male; D014055:Tomography, Emission-Computed; D015899:Tomography, Emission-Computed, Single-Photon