In vitro activity of Bay 12-8039, a new 8-methoxyquinolone.
MICs of Bay 12-8039 and comparative antimicrobials were determined for 820 recent clinical isolates. Ciprofloxacin was approximately 2-fold more active than Bay 12-8039 and ofloxacin against Enterobacteriaceae and approximately 8-fold more active against Pseudomonas aeruginosa. Bay 12-8039 was approximately 2- to 16-fold more active than ciproiloxacin and ofloxacin against nonfermenters (except P. aeruginosa), staphylococci, streptococci, enterococci, and anaerobes. As determined by regression analysis, there was a high degree of correlation among quinolone MICs.
Fass
R J
RJ
Department of Internal Medicine, Ohio State University College of Medicine, Columbus 43210, USA. fass.1@osu.edu
D000890:Anti-Infective Agents / Q000494:pharmacology*; D001372:Aza Compounds; D001419:Bacteria / Q000187:drug effects; D024841:Fluoroquinolones; D006801:Humans; D066298:In Vitro Techniques; D008826:Microbial Sensitivity Tests; D000077266:Moxifloxacin; D011550:Pseudomonas aeruginosa / Q000187:drug effects*; D011804:Quinolines; D015363:Quinolones / Q000494:pharmacology*; D012044:Regression Analysis
D000890:Anti-Infective Agents; D001372:Aza Compounds; D024841:Fluoroquinolones; D011804:Quinolines; D015363:Quinolones; D000077266:Moxifloxacin