title: 1997 Harry M. Vars Research Award. Does the route of feeding modify gut barrier function and clinical outcome in patients after major upper gastrointestinal surgery?
abstract: BACKGROUND
  Direct experimental evidence suggests that total enteral nutrition (TEN) reduces septic morbidity compared with bowel rest and total parenteral nutrition (TPN) and that mucosal support and maintenance of gut barrier function is a key mechanism. This effect is supported indirectly by clinical studies, but this question has not previously been investigated directly in the postoperative patient. This study examined the hypothesis that early enteral feeding after major upper gastrointestinal surgery may modulate gut barrier function and decrease the risk of major infective complications compared with bowel rest and parenteral nutrition.
  
  
  METHODS
  A randomized clinical trial of 67 patients (TPN = 34; TEN = 33) fed postoperatively for 7 days was performed. Thirty-day major morbidity and mortality were monitored. Intestinal permeability was measured using the lactulose/mannitol test preoperatively and on postoperative days 1 and 7. Systemic anti-endotoxin core immunoglobulin G and M antibodies and serum albumin and C-reactive protein were quantified at these time points.
  
  
  RESULTS
  No clinical benefit was observed in patients fed enterally compared with the parenterally fed group. Intestinal permeability was increased on the 1st postoperative day in association with evidence of endotoxin exposure. By day 7, enteral feeding compared with parenteral feeding had failed to significantly influence any of the gut barrier or systemic parameters.
  
  
  CONCLUSIONS
  This randomized controlled trial of TEN vs TPN after major upper gastrointestinal surgery failed to show a clinical benefit for the enteral route. Moreover, enteral nutrition did not modulate gut barrier function postoperatively.
authors.affiliation: Professorial Surgical Unit, St James's University Hospital, Leeds, England.
authors.forename: J V
authors.initials: JV
authors.lastname: Reynolds
authors.forename: S
authors.initials: S
authors.lastname: Kanwar
authors.forename: F K
authors.initials: FK
authors.lastname: Welsh
authors.forename: A C
authors.initials: AC
authors.lastname: Windsor
authors.forename: P
authors.initials: P
authors.lastname: Murchan
authors.forename: G R
authors.initials: GR
authors.lastname: Barclay
authors.forename: P J
authors.initials: PJ
authors.lastname: Guillou
mesh_terms: D000906:Antibodies / Q000097:blood; D001363:Awards and Prizes; D002097:C-Reactive Protein / Q000378:metabolism; D004068:Digestive System Physiological Phenomena; D013505:Digestive System Surgical Procedures; D004731:Endotoxins / Q000276:immunology; D004750:Enteral Nutrition; D004938:Esophageal Neoplasms / Q000601:surgery; D006801:Humans; D010190:Pancreatic Neoplasms / Q000601:surgery; D010289:Parenteral Nutrition, Total; D010539:Permeability; D012108:Research Personnel; D012709:Serum Albumin / Q000378:metabolism; D013274:Stomach Neoplasms / Q000601:surgery; D016896:Treatment Outcome
chemical_list: D000906:Antibodies; D004731:Endotoxins; D012709:Serum Albumin; D002097:C-Reactive Protein