Evaluation of 153Sm-diethylenetriaminepentaacetic acid for radiolabelling of pharmaceutical dosage forms by neutron activation.
153Sm-DTPA provides a suitable alternative to 99mTc-DTPA and 111In-DTPA as a water soluble tracer for the evaluation of pharmaceutical preparations. The chelate was handled biologically in a similar way to 99mTc-DTPA and 111In-DTPA. The chelate can be incorporated into the formulation as a non-radioactive excipient and the intact dosage form can then be neutron activated to produce 153Sm.
Awang
M B
MB
Department of Pharmaceutical Sciences, Nottingham University, U.K.
Hardy
J G
JG
Davis
S S
SS
Pimm
M V
MV
Parry
S J
SJ
Wilding
I R
IR
D000280:Administration, Inhalation; D000284:Administration, Oral; D000818:Animals; D004304:Dosage Forms; D005069:Evaluation Studies as Topic; D005260:Female; D051379:Mice; D008807:Mice, Inbred BALB C; D009502:Neutrons; D004369:Pentetic Acid / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics*; D010599:Pharmacokinetics; D019275:Radiopharmaceuticals / Q000008:administration & dosage / Q000493:pharmacokinetics*; D012493:Samarium; D016284:Technetium Tc 99m Pentetate / Q000008:administration & dosage / Q000493:pharmacokinetics; D014018:Tissue Distribution
D004304:Dosage Forms; D019275:Radiopharmaceuticals; D012493:Samarium; D004369:Pentetic Acid; D016284:Technetium Tc 99m Pentetate