title: Calorie restriction induces a p53-independent delay of spontaneous carcinogenesis in p53-deficient and wild-type mice.
abstract: We reported previously that calorie restriction (CR) delays spontaneous carcinogenesis in p53-deficient (p53-/-) mice, suggesting that CR modulates carcinogenesis by p53-independent mechanisms. To further evaluate the role of p53, we monitored tumor development in p53-/- and wild-type (p53+/+) mice fed ad libitum (AL) or a CR regimen (60% of AL calorie intake). CR delayed tumor mortality in p53-/- and p53+/+ mice (mean time to death, 169 and 648 days, respectively) relative to AL feeding (104 and 470 days). The estimated age-specific cancer death rate AL:CR ratios were 4.3 for p53-/- mice and 4.4 for p53+/+ mice. Thus, despite the accelerated onset of carcinogenesis in p53-/- mice, the tumor-delaying effect of CR was similar in the two genotypes.
authors.affiliation: Division of Basic Sciences, National Cancer Institute, NIH, Frederick Cancer Research and Development Center, Maryland 21702-1201, USA.
authors.forename: S D
authors.initials: SD
authors.lastname: Hursting
authors.forename: S N
authors.initials: SN
authors.lastname: Perkins
authors.forename: C C
authors.initials: CC
authors.lastname: Brown
authors.forename: D C
authors.initials: DC
authors.lastname: Haines
authors.forename: J M
authors.initials: JM
authors.lastname: Phang
mesh_terms: D000818:Animals; D004038:Diet, Reducing; D002149:Energy Intake; D051379:Mice; D009374:Neoplasms, Experimental / Q000517:prevention & control*; D016159:Tumor Suppressor Protein p53 / Q000502:physiology*
chemical_list: D016159:Tumor Suppressor Protein p53