title: Chromophobe cell renal carcinoma: DNA flow cytometry and proliferation status in 9 cases.
abstract: Nine cases of chromophobe cell renal carcinoma are reported, 2 in pregnant women. One neoplasm progressed and the patient died of disease, and this tumor presented the highest mitotic index and focal positivity to Ki-67 antibody. DNA flow-cytometric study discovered 89% of aneuploidy, with 3 tetraploid cases. We conclude that chromophobe cell renal carcinoma is a relatively indolent but clearly malignant neoplasm. We suggest that the mitotic index could be the best method to predict malignant behavior. The high incidence of aneuploid cell lines may be due to structural anomalies; it is not indicative of malignant behavior.
authors.affiliation: Department of Anatomical Pathology, Marqués de Valdecilla University Hospital, Medical Faculty, University of Cantabria, Santander, Spain.
authors.forename: J J
authors.initials: JJ
authors.lastname: Gómez-Román
authors.forename: F
authors.initials: F
authors.lastname: Fernández
authors.forename: L
authors.initials: L
authors.lastname: Buelta-Carrillo
authors.forename: J F
authors.initials: JF
authors.lastname: Val-Bernal
mesh_terms: D000328:Adult; D000368:Aged; D000782:Aneuploidy; D002292:Carcinoma, Renal Cell / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D004273:DNA, Neoplasm / Q000032:analysis*; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D019394:Ki-67 Antigen / Q000032:analysis; D007668:Kidney / Q000473:pathology; D007680:Kidney Neoplasms / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D008297:Male; D008875:Middle Aged; D008940:Mitotic Index; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000473:pathology
chemical_list: D004273:DNA, Neoplasm; D019394:Ki-67 Antigen