[Intracranial chordomas; histochemical and immunohistochemical examinations].
Chordoma is one of rare intracranial neoplasms (0.2-0.5%). Apart from classic chordoma in 1973 r. Heffelfinger and al. separated chondroid chordoma which showed better prognosis. We studied 4 classic and 3 chondroid intracranial chordomas. All tumours contained chondroitine sulfate and keratan sulfate and showed positive immunohistochemical reactions to cytokeratin, S-100 protein and vimentin, supporting the concept of common origin of both types of chordomas. Immunohistochemical studies of PCNA and Ki-67 antigen and staining AgNOR's did not show significant differences in the proliferative activity between both types chordomas what attests to biological malignancy.
Zimnoch
L
L
Zakładu Anatomii Patologicznej AM w Białymstoku.
Kozielec
Z
Z
Lewko
J
J
Baltaziak
M
M
Mariak
Z
Z
D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis*; D001932:Brain Neoplasms / Q000473:pathology*; D002809:Chondroitin Sulfates / Q000032:analysis; D002817:Chordoma / Q000469:parasitology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007632:Keratan Sulfate / Q000032:analysis; D007633:Keratins / Q000032:analysis; D019394:Ki-67 Antigen / Q000032:analysis; D008297:Male; D008875:Middle Aged; D018809:Proliferating Cell Nuclear Antigen / Q000032:analysis; D009418:S100 Proteins / Q000032:analysis; D014746:Vimentin / Q000032:analysis
D014408:Biomarkers, Tumor; D019394:Ki-67 Antigen; D018809:Proliferating Cell Nuclear Antigen; D009418:S100 Proteins; D014746:Vimentin; D007633:Keratins; D002809:Chondroitin Sulfates; D007632:Keratan Sulfate
Struniaki wewnatrzczaszkowe; badania histochemiczne i immunohistochemiczne.