title: Complementary value of five carcinoma markers for the diagnosis of malignant mesothelioma, adenocarcinoma metastasis, and reactive mesothelium in serous effusions.
abstract: Cytological slides of serous fluids of 41 malignant mesotheliomas, 88 metastatic adenocarcinomas, and 25 reactive effusions were immunostained with the antibodies anti-CEA, MOC-31, Leu-M1, Ber-EP4, and B72.3. Most mesotheliomas and all reactive fluids failed to stain with these antibodies. The sensitivity of the five markers to detect carcinoma cells differed remarkably. Especially MOC-31, Ber-EP4, and B72.3 stained with a high number of carcinoma cases and the complemetary value of Ber-EP4 and B72.3 to immunostain carcinoma cells was impressive: 94% of the metastatic adenocarcinoma cases reacted with Ber-EP4 or B72.3 in contrast to 1 of 41 malignant mesotheliomas.
authors.affiliation: Department of Pathology, Erasmus University, Rotterdam, The Netherlands.
authors.forename: M
authors.initials: M
authors.lastname: Delahaye
authors.forename: F
authors.initials: F
authors.lastname: van der Ham
authors.forename: T H
authors.initials: TH
authors.lastname: van der Kwast
mesh_terms: D000230:Adenocarcinoma / Q000737:chemistry / Q000175:diagnosis* / Q000473:pathology / Q000556:secondary; D000911:Antibodies, Monoclonal; D000912:Antibodies, Neoplasm; D014408:Biomarkers, Tumor; D006801:Humans; D007150:Immunohistochemistry; D008654:Mesothelioma / Q000737:chemistry / Q000175:diagnosis* / Q000473:pathology; D010534:Peritoneal Neoplasms / Q000737:chemistry / Q000175:diagnosis* / Q000473:pathology; D010996:Pleural Effusion / Q000737:chemistry / Q000166:cytology* / Q000473:pathology; D010997:Pleural Neoplasms / Q000737:chemistry / Q000175:diagnosis* / Q000473:pathology
chemical_list: D000911:Antibodies, Monoclonal; D000912:Antibodies, Neoplasm; D014408:Biomarkers, Tumor