title: Management of swallowing disorders and chronic aspiration by glottic closure procedure.
abstract: We report an 18-year-old man with a posterior fossa tumor who had to undergo a partial resection of the tumor and supportive radiation therapy. Functional deficits of the lower cranial nerves, particularly the glossopharyngeal and vagal nerves, associated with severe swallowing disorders and refractory aspiration pneumonia were seen postoperatively. The admission to the intensive care unit (ICU) resulted from increasing respiratory failure accompanied by recurrent septic episodes. Nutritional support via nasogastric tube and later percutaneous endoscopic gastrostomy (PEG) were hampered by complications such as persistent sinusitis, local dermatitis surrounding the entrance of the PEG tube, and the development of duodenal ulcers. Furthermore, the use of continuous subglottic aspiration failed to prevent pulmonary infections. After a 9-week stay in the ICU due to inadequate antimicrobial therapy of aspiration pneumonia and the patient's persistent sepsis, a temporary surgical separation of airway and food passages was performed by glottic closure. Subsequently chronic aspiration stopped, and 3 months after admission to the ICU, the patient had stable vital organ function and was transferred to a surgical ward free of infections. Glottic closure was reversed successfully 7 months later. When compared with laryngeal function on admission, there was no more impairment. Thus, temporary glottic closure seems to be an efficacious treatment to prevent life-threatening septic complications in patients with refractory aspiration pneumonia.
authors.affiliation: Department of Anesthesiology and Intensive Therapy, University Hospital Charité, Humboldt University Berlin, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Hensel
authors.forename: K
authors.initials: K
authors.lastname: Haake
authors.forename: S
authors.initials: S
authors.lastname: Vogel
authors.forename: W
authors.initials: W
authors.lastname: Flügel
authors.forename: D
authors.initials: D
authors.lastname: Krausch
authors.forename: W J
authors.initials: WJ
authors.lastname: Kox
mesh_terms: D000293:Adolescent; D001932:Brain Neoplasms / Q000150:complications / Q000601:surgery / Q000628:therapy; D002908:Chronic Disease; D003388:Cranial Fossa, Posterior; D003680:Deglutition Disorders / Q000601:surgery*; D005774:Gastrostomy; D005931:Glottis / Q000601:surgery*; D006801:Humans; D007442:Intubation, Intratracheal; D008297:Male; D011015:Pneumonia, Aspiration / Q000382:microbiology / Q000601:surgery*; D012121:Respiration, Artificial