title: An unusual axonal polyneuropathy induced by low-dose interferon alfa-2a.
abstract: OBJECTIVE
  To describe a patient who developed an unusual polyneuropathy after treatment with interferon alfa-2a for hepatitis C and to discuss issues related to diagnosis and pathogenesis.
  
  
  METHODS
  Case report.
  
  
  METHODS
  Tertiary care center.
  
  
  METHODS
  A 46-year-old man with chronic hepatitis C had acute onset of an axonal polyneuropathy with prominent small-fiber involvement shortly after completing a standard 6-month course of therapy with low-dose interferon alfa-2a.
  
  
  RESULTS
  Further interferon treatment for hepatitis C was discontinued.
  
  
  CONCLUSIONS
  Standard, low-dose interferon alfa-2a treatment can produce a persistent predominantly small-fiber polyneuropathy.
authors.affiliation: Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Mass, USA.
authors.forename: S B
authors.initials: SB
authors.lastname: Rutkove
mesh_terms: D001369:Axons / Q000187:drug effects; D004594:Electrophysiology; D006526:Hepatitis C / Q000188:drug therapy; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D016472:Motor Neuron Disease / Q000139:chemically induced*; D011994:Recombinant Proteins; D012867:Skin / Q000187:drug effects / Q000503:physiopathology
chemical_list: D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins