title: Assessment of mitral annulus velocity by Doppler tissue imaging in the evaluation of left ventricular diastolic function.
abstract: OBJECTIVE
  This study assessed the clinical utility of mitral annulus velocity in the evaluation of left ventricular diastolic function.
  
  
  BACKGROUND
  Mitral inflow velocity recorded by Doppler echocardiography has been widely used to evaluate left ventricular diastolic function but is affected by other factors. The mitral annulus velocity profile during diastole may provide additional information about left ventricular diastolic function.
  
  
  METHODS
  Mitral annulus velocity during diastole was measured by Doppler tissue imaging (DTI) 1) in 59 normal volunteers (group 1); 2) in 20 patients with a relaxation abnormality as assessed by Doppler mitral inflow variables (group 2) at baseline and after saline loading; 3) in 11 patients (group 3) with normal diastolic function before and after intravenous nitroglycerin infusion; and 4) in 38 consecutive patients (group 4) undergoing cardiac catheterization in whom mitral inflow velocity and tau as well as mitral annulus velocity were measured simultaneously.
  
  
  RESULTS
  In group 1, mean +/- SD peak early and late diastolic mitral annulus velocity was 10.0 +/- 1.3 and 9.5 +/- 1.5 cm/s, respectively. In group 2, mitral inflow velocity profile changed toward the pseudonormalization pattern with saline loading (deceleration time 311 +/- 84 ms before to 216 +/- 40 ms after intervention, p < 0.001), whereas peak early diastolic mitral annulus velocity did not change significantly (5.3 +/- 1.2 cm/s to 5.7 +/- 1.4 cm/s, p = NS). In group 3, despite a significant change in mitral inflow velocity profile after nitroglycerin, peak early diastolic mitral annulus velocity did not change significantly (9.5 +/- 2.2 cm/s to 9.2 +/- 1.7 cm/s, p = NS). In group 4, peak early diastolic mitral annulus velocity (r = -0.56, p < 0.01) and the early/late ratio (r = -0.46, p < 0.01) correlated with tau. When the combination of normal mitral inflow variables with prolonged tau (> or = 50 ms) was classified as pseudonormalization, peak early diastolic mitral annulus velocity < 8.5 cm/s and the early/late ratio < 1 could identify the pseudonormalization with a sensitivity of 88% and specificity of 67%.
  
  
  CONCLUSIONS
  Mitral annulus velocity determined by DTI is a relatively preload-independent variable in evaluating diastolic function.
authors.affiliation: Department of Internal Medicine, Seoul National University College of Medicine, Korea.
authors.forename: D W
authors.initials: DW
authors.lastname: Sohn
authors.forename: I H
authors.initials: IH
authors.lastname: Chai
authors.forename: D J
authors.initials: DJ
authors.lastname: Lee
authors.forename: H C
authors.initials: HC
authors.lastname: Kim
authors.forename: H S
authors.initials: HS
authors.lastname: Kim
authors.forename: B H
authors.initials: BH
authors.lastname: Oh
authors.forename: M M
authors.initials: MM
authors.lastname: Lee
authors.forename: Y B
authors.initials: YB
authors.lastname: Park
authors.forename: Y S
authors.initials: YS
authors.lastname: Choi
authors.forename: J D
authors.initials: JD
authors.lastname: Seo
authors.forename: Y W
authors.initials: YW
authors.lastname: Lee
mesh_terms: D000328:Adult; D003971:Diastole / Q000502:physiology*; D015150:Echocardiography, Doppler; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008943:Mitral Valve / Q000502:physiology*; D005996:Nitroglycerin / Q000494:pharmacology; D014665:Vasodilator Agents / Q000494:pharmacology; D016277:Ventricular Function, Left / Q000502:physiology*
chemical_list: D014665:Vasodilator Agents; D005996:Nitroglycerin