title: Combinatorial synthesis of small-molecule libraries using 3-amino-5-hydroxybenzoic acid.
abstract: A non-peptide library of 2001 compounds has been prepared utilizing solid-phase techniques. The split/combine method was demonstrated to work well to form mixtures of compounds based on 3-amino-5-hydroxybenzoic acid as a core structure. The benzoic acid of the core structure served as the attachment point for the resin and the amino and hydroxy positions were variably substituted.
authors.affiliation: Syntex Discovery Research, Chemical Research and Development, Palo Alto, CA 94304, USA.
authors.forename: S M
authors.initials: SM
authors.lastname: Dankwardt
authors.forename: T M
authors.initials: TM
authors.lastname: Phan
authors.forename: J L
authors.initials: JL
authors.lastname: Krstenansky
mesh_terms: D062365:Aminobenzoates / Q000138:chemical synthesis* / Q000737:chemistry*; D002625:Chemistry, Organic; D002851:Chromatography, High Pressure Liquid; D019020:Directed Molecular Evolution / Q000379:methods*; D015195:Drug Design; D062385:Hydroxybenzoates; D015394:Molecular Structure; D055601:Organic Chemistry Phenomena; D012117:Resins, Synthetic / Q000138:chemical synthesis / Q000737:chemistry
chemical_list: D062365:Aminobenzoates; D062385:Hydroxybenzoates; D012117:Resins, Synthetic; C031509:3-amino-5-hydroxybenzoic acid