Pergolide to augment the effectiveness of antidepressants: clinical experience and a small double-blind study.
To attempt to confirm a prior report that pergolide can augment the efficacy of antidepressants in refractory patients, pergolide was administered to 12 patients receiving antidepressants. Eight patients were involved in a placebo-controlled evaluation of pergolide; the others were prescribed pergolide clinically. Results showed no evidence of benefit, so the double-blind study has been discontinued.
Mattes
J A
JA
Psychopharmacology Research Association of Princeton, New Jersey 08540, USA.
D000277:Adjuvants, Pharmaceutic / Q000008:administration & dosage; D000328:Adult; D000928:Antidepressive Agents / Q000008:administration & dosage*; D003866:Depressive Disorder / Q000188:drug therapy*; D018491:Dopamine Agonists / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D010479:Pergolide / Q000627:therapeutic use*; D016896:Treatment Outcome
D000277:Adjuvants, Pharmaceutic; D000928:Antidepressive Agents; D018491:Dopamine Agonists; D010479:Pergolide