title: Development of intracoronary local adhesive delivery technique.
abstract: Acute coronary occlusion may occur in weak coronary atherosclerotic lesions, including dissection, ulceration or thrombus. In some cases of occlusion "bail-out" is performed by using recently developed New Devices. However, these have not yet completely solved the problem to this end, we designed a new method of coronary revascularization, the Intracoronary Local Adhesive Delivery Technique, utilizing antithrombotic and absorbable adhesive injected locally into the fragile and morbid arterial wall using a drug delivery PTCA catheter more flexible than the existing New Devices. This adhesive strengthened and hardened the lesions. In this study, we examined the efficacy of making an adhesive cylinder in arteries of similar size to the coronary, through acute animal experiments using the existing clinical adhesives and drug delivery PTCA catheters and 12 femoral arteries of adult goats. We were successful in forming firm tunnels along the inside of six arteries, infused with approximately 0.04 ml Cyanoacrylate. These tunnels were observed with intravascular ultrasound (IVUS) imaging and evaluated microscopically. These results suggest the feasibility of this method as a new approach for making synthetic resinous stents.
authors.affiliation: Department of Medical Engineering and Cardiology, Tokoku University, Sendai, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Sonobe
authors.forename: S
authors.initials: S
authors.lastname: Naganuma
authors.forename: T
authors.initials: T
authors.lastname: Yambe
authors.forename: S I
authors.initials: SI
authors.lastname: Kobayashi
authors.forename: K
authors.initials: K
authors.lastname: Sizuka
authors.forename: Y
authors.initials: Y
authors.lastname: Katahira
authors.forename: K
authors.initials: K
authors.lastname: Nitta
authors.forename: S I
authors.initials: SI
authors.lastname: Nitta
mesh_terms: D000042:Absorption; D015906:Angioplasty, Balloon, Coronary; D000818:Animals; D003327:Coronary Disease / Q000209:etiology / Q000628:therapy*; D003487:Cyanoacrylates / Q000008:administration & dosage* / Q000378:metabolism; D004195:Disease Models, Animal; D016503:Drug Delivery Systems / Q000592:standards*; D005240:Feasibility Studies; D005260:Female; D005343:Fibrinolytic Agents / Q000008:administration & dosage* / Q000378:metabolism; D006041:Goats; D008297:Male; D009204:Myocardial Revascularization; D015607:Stents; D014014:Tissue Adhesives / Q000592:standards / Q000627:therapeutic use*
chemical_list: D003487:Cyanoacrylates; D005343:Fibrinolytic Agents; D014014:Tissue Adhesives