Current concepts in intestinal peptide absorption.
Today there is considerable interest in oral peptide delivery. However, oral administration of peptides is limited by a low bioavailability and a high variability in plasma levels. A review is given of the literature describing the major barriers in peptide absorption, the basic mechanisms of intestinal peptide transport, the experimental models and the pharmaceutical approaches currently used in the investigation of peptide and protein absorption processes.
Fricker
G
G
Institut für Pharmazeutische Technologie und Biopharmazie, Ruprecht-Karls-Universität, Heidelberg, Germany. jw3@ix.urz.uni.heidelberg.de
Drewe
J
J
D000818:Animals; D001692:Biological Transport; D055598:Chemical Phenomena; D002626:Chemistry, Pharmaceutical / Q000639:trends; D002627:Chemistry, Physical; D006801:Humans; D007408:Intestinal Absorption; D010455:Peptides / Q000493:pharmacokinetics*; D011506:Proteins / Q000493:pharmacokinetics
D010455:Peptides; D011506:Proteins