title: [Myopathy caused by inhibitors of hydroxymethylglutaryl-coenzyme A reductase].
abstract: BACKGROUND
  Hydroxymethylglutaryl-Coenzyme A (HMG-CoA) Reductase inhibitors are a group of drugs widely used for hypercholesterolemia. They are known to originate side-effects on muscles but with a very low incidence of myopathy.
  
  
  METHODS
  We present two cases of myopathy induced by HMG-CoA reductase inhibitors. They are two women, who were on 20 mg daily of lovastatin and 30 mg daily of simvastatin and consulted due to weakness, myalgia and a rise in blood levels of muscle enzymes. Both of them recovered completely a few weeks after withdrawal of the drugs.
  
  
  CONCLUSIONS
  Usage of this group of drugs is wide. Their side effects are rare but it is important to remember their capacity to induce a myopathy, usually reversible upon withdrawal of the drug.
authors.affiliation: Servicio de Neurologia, Hospital Universitario Virgen de la Arrixaca, Murcia, Espana.
authors.forename: F A
authors.initials: FA
authors.lastname: Martinez-García
authors.forename: J
authors.initials: J
authors.lastname: Martín-Fernández
authors.forename: J M
authors.initials: JM
authors.lastname: Moltó
authors.forename: R
authors.initials: R
authors.lastname: Villaverde
authors.forename: A
authors.initials: A
authors.lastname: Morales
authors.forename: A
authors.initials: A
authors.lastname: Fernández-Barreiro
mesh_terms: D004576:Electromyography; D004791:Enzyme Inhibitors / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000009:adverse effects*; D008148:Lovastatin / Q000008:administration & dosage / Q000009:adverse effects* / Q000031:analogs & derivatives*; D008875:Middle Aged; D017240:Mitochondrial Myopathies / Q000139:chemically induced* / Q000175:diagnosis; D019821:Simvastatin
chemical_list: D004791:Enzyme Inhibitors; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D008148:Lovastatin; D019821:Simvastatin
vernacular_title: Miopatía producida por inhibidores de la hidroxi-metilglutaril-coenzima A reductasa.