title: New indole derivatives with free radical scavenging activity from Agrocybe cylindracea.
abstract: Two new indole derivatives were isolated as free radical scavengers from the MeOH extract of Agrocybe cylindracea. The structures of these compounds were determined to be 6-hydroxy-1H-indole-3-carboxaldehyde (1) and 6-hydroxy-1H-indole-3-acetamide (2) on the basis of spectroscopic studies. Compounds 1 and 2 inhibited lipid peroxidation in rat liver microsomes, with IC50 values of 4.1 and 3.9 micrograms/mL, respectively.
authors.affiliation: Korea Research Institute of Bioscience and Biotechnology, KIST, Yusong, Taejon, Korea.
authors.forename: W G
authors.initials: WG
authors.lastname: Kim
authors.forename: I K
authors.initials: IK
authors.lastname: Lee
authors.forename: J P
authors.initials: JP
authors.lastname: Kim
authors.forename: I J
authors.initials: IJ
authors.lastname: Ryoo
authors.forename: H
authors.initials: H
authors.lastname: Koshino
authors.forename: I D
authors.initials: ID
authors.lastname: Yoo
mesh_terms: D000818:Animals; D001487:Basidiomycota / Q000737:chemistry*; D016166:Free Radical Scavengers / Q000494:pharmacology*; D007211:Indoles / Q000737:chemistry* / Q000494:pharmacology; D015227:Lipid Peroxidation / Q000187:drug effects; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D013057:Spectrum Analysis
chemical_list: C107717:6-hydroxy-1H-indole-3-acetamide; C107718:6-hydroxy-1H-indole-3-carboxaldehyde; D016166:Free Radical Scavengers; D007211:Indoles