Primary biliary cirrhosis and gastric carcinoid: a rare association?
Primary biliary cirrhosis (PBC) is frequently associated with other autoimmune disorders. Although antibodies against gastric parietal cells are found in nearly all PBC patients, autoimmune gastritis is only very rarely associated. We describe a woman with PBC in whom chronic autoimmune gastritis complicated by a large pedunculated gastric carcinoid tumor was found. Additionally, the patient had autoimmune thyroiditis. This was interpreted as the rare association of PBC with Schmidt's syndrome type III. The carcinoid tumor was removed endoscopically. We conclude from the case that an endoscopic screening for autoimmune gastritis should at least be performed in patients with PBC and autoimmune thyroiditis, keeping in mind the possible occurrence of a polyendocrinopathy and the potentially serious complication of a gastric carcinoid tumor.
Mörk
H
H
Medizinische Poliklinik, University of Würzburg, Germany.
Jakob
F
F
al-Taie
O
O
Gassel
A M
AM
Scheurlen
M
M
D002276:Carcinoid Tumor / Q000150:complications* / Q000276:immunology; D005260:Female; D005756:Gastritis / Q000150:complications* / Q000276:immunology; D006801:Humans; D008105:Liver Cirrhosis, Biliary / Q000150:complications* / Q000276:immunology; D008875:Middle Aged; D016884:Polyendocrinopathies, Autoimmune / Q000150:complications* / Q000276:immunology; D013274:Stomach Neoplasms / Q000150:complications* / Q000276:immunology