title: MnDPDP-enhanced MR imaging of the liver. Correlation with surgical findings.
abstract: OBJECTIVE
  To compare lesion detection and characterisation predicted by MnDPDP-enhanced MR imaging with surgical excision and pathological examination.
  
  
  METHODS
  Ninety patients were intravenously infused at a rate of 2 to 3 ml/min with 5 mumol/kg mangafodipir trisodium (MnDPDP, Teslascan). The patients were examined with spin-echo and gradient-echo T1-weighted MR imaging at 1 h and 24 h after the end of infusion. The results were compared with identical pre-contrast sequences. In 20 of these patients, the pre-operative MR findings were compared with intra-operative ultrasonography and histology of the resected liver specimens.
  
  
  RESULTS
  In those with liver metastases, there was a good correlation between MR and the hepatic disease in 11 out of 14 cases. In the group with primary liver tumours, MR findings correlated with hepatic disease in 5 out of 6 cases.
  
  
  CONCLUSIONS
  Liver lesion characterisation is possible with MnDPDP, and MR contrast enhancement with this agent is considered to be an important adjunct to the radiological assessment of patients with neoplastic liver disease where accurate decisions for surgical planning are imperative.
authors.affiliation: Department of Radiology, Kings College Hospital, London, UK.
authors.forename: P A
authors.initials: PA
authors.lastname: Kane
authors.forename: V
authors.initials: V
authors.lastname: Ayton
authors.forename: H L
authors.initials: HL
authors.lastname: Walters
authors.forename: I
authors.initials: I
authors.lastname: Benjamin
authors.forename: N D
authors.initials: ND
authors.lastname: Heaton
authors.forename: R
authors.initials: R
authors.lastname: Williams
authors.forename: J B
authors.initials: JB
authors.lastname: Karani
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D003287:Contrast Media / Q000008:administration & dosage; D004492:Edetic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives*; D005260:Female; D006168:Guinea Pigs; D006801:Humans; D008099:Liver / Q000473:pathology* / Q000601:surgery*; D008113:Liver Neoplasms / Q000175:diagnosis / Q000556:secondary / Q000601:surgery; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008345:Manganese / Q000008:administration & dosage; D008875:Middle Aged; D011732:Pyridoxal Phosphate / Q000008:administration & dosage / Q000031:analogs & derivatives*
chemical_list: D003287:Contrast Media; D008345:Manganese; D011732:Pyridoxal Phosphate; D004492:Edetic Acid; C060076:N,N'-bis(pyridoxal-5-phosphate)ethylenediamine-N,N'-diacetic acid