A new 99mTc-complex with a germanium-hydrazide (GeTH) ligand.
A new tetrahydrazido-germanium (GeTH) ligand was synthesized, characterized and complexed with 99mTc. The negatively charged 99mTc-chelate was shown to form in high yields at neutral pH in the absence of other reducing agents and exhibits high in vitro and in vivo stability.
Singh
P R
PR
Department of Radiology, University of Missouri, Columbia, USA.
Katti
K K
KK
Katti
K V
KV
Corlija
M
M
Ketring
A R
AR
Volkert
W A
WA
Holmes
R R
RR
D000818:Animals; D006834:Hydrazines / Q000493:pharmacokinetics; D006863:Hydrogen-Ion Concentration; D015609:Organotechnetium Compounds / Q000493:pharmacokinetics; D010084:Oxidation-Reduction; D011854:Radiochemistry; D019275:Radiopharmaceuticals / Q000737:chemistry* / Q000493:pharmacokinetics; D051381:Rats; D017207:Rats, Sprague-Dawley; D014018:Tissue Distribution
D006834:Hydrazines; D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; C107870:technetium Tc 99m tetrakis(hydrazidomethyl)germanium