title: Invasive antenatal procedures and requirement for neonatal intensive care unit admission.
abstract: Neonatal respiratory difficulties are increased following second trimester amniocentesis. In preterm, prolonged rupture of the membranes, respiratory outcome is particularly poor when rupture occurs in the first trimester. It therefore seems likely that first trimester/ early amniocentesis (EA) would be associated with severe respiratory problems necessitating a high neonatal intensive care unit (NICU) admission rate. To test that hypothesis, the requirement for admission to the NICU of 278 infants whose mothers had undergone EA, 262 whose mothers had undergone chorion villus sampling (CVS group) and 264 controls whose mothers had undergone no invasive procedures were reviewed as were their diagnoses if they needed admission. There was no significant difference in the mode of delivery, gestational age or gender distribution of the three groups and the median maternal age of the EA and CVS groups was similar. Nineteen EA, eight CVS and five control infants required admission to the NICU (EA versus controls, P < 0.01; EA versus CVS plus controls, P < 0.005). Nine EA, one CVS and four control infants had suffered respiratory problems (EA versus CVS P < 0.05). Logistic regression analysis demonstrated that immaturity and EA were significantly associated with a requirement for NICU admission. We conclude infants whose mothers have undergone EA may be at increased risk for NICU admission, this is partly due to respiratory problems but the association is uncommon.
authors.affiliation: Department of Child Health, King's College Hospital, London, U.K.
authors.forename: A
authors.initials: A
authors.lastname: Greenough
authors.forename: B
authors.initials: B
authors.lastname: Yuksel
authors.forename: S
authors.initials: S
authors.lastname: Naik
authors.forename: P
authors.initials: P
authors.lastname: Cheeseman
authors.forename: K H
authors.initials: KH
authors.lastname: Nicolaides
mesh_terms: D000649:Amniocentesis / Q000009:adverse effects*; D015193:Chorionic Villi Sampling / Q000009:adverse effects*; D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000453:epidemiology*; D015931:Intensive Care, Neonatal / Q000706:statistics & numerical data*; D016015:Logistic Models; D008131:London / Q000453:epidemiology; D011247:Pregnancy; D012140:Respiratory Tract Diseases / Q000453:epidemiology*