title: [The effect of prostatilen on the hemostatic indices in chronic prostatitis (a clinical and experimental study)].
abstract: Prostatilen effects on hemostasis were studied in 120 intact and 240 chronic prostatitis rats, 34 patients with chronic prostatitis. Intact rats responded to prostatilen by inhibition of platelet-vascular and coagulation hemostatic mechanisms and activation of fibrinolysis. Experimental chronic prostatitis in rats induced hemostatic shifts to hypercoagulation. These parameters returned to normal after 5- and 10-day course of prostatilen administration. A single prostatilen dose was unable to produce the above action. As to patients with chronic prostatitis, there were also prostatilen-induced platelet-vascular hemostatic normalization and fibrinolysis activation. Hemocoagulation was affected in a less degree. Prostatilen effects were unrelated to the disease stage. Normalization of hemostasis seems to be one of the factors of prostatilen therapeutic efficacy in chronic prostatitis. This peptide is found effective as a pathogenetic treatment of chronic prostatitis.
authors.forename: S Kh
authors.initials: SKh
authors.lastname: al-Shukri
authors.forename: N N
authors.initials: NN
authors.lastname: Petrishchev
authors.forename: A G
authors.initials: AG
authors.lastname: Gorbachev
authors.forename: I A
authors.initials: IA
authors.lastname: Mikhaĭlova
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Bobkov
authors.forename: I V
authors.initials: IV
authors.lastname: Kuz'min
authors.forename: S Iu
authors.initials: SIu
authors.lastname: Borovets
authors.forename: I B
authors.initials: IB
authors.lastname: Savel'eva
authors.forename: M V
authors.initials: MV
authors.lastname: Korokhodkina
mesh_terms: D000818:Animals; D002908:Chronic Disease; D004341:Drug Evaluation; D004353:Drug Evaluation, Preclinical; D006487:Hemostasis / Q000187:drug effects*; D006801:Humans; D008297:Male; D010455:Peptides / Q000494:pharmacology / Q000627:therapeutic use*; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D011472:Prostatitis / Q000097:blood / Q000188:drug therapy*; D051381:Rats
chemical_list: D010455:Peptides; D010975:Platelet Aggregation Inhibitors; C069549:prostatilen
vernacular_title: Vliianie prostatilena na pokazateli gemostaza pri khronicheskom prostatite (kliniko-éksperimental'noe issledovanie).