Synthetic library techniques: subjective (biased and generic) thoughts and views.
Various aspects of synthetic diversity generation and screening are discussed. Controversial issues are raised and different points of view are presented. We hope the article will stimulate thinking about the utilization of library techniques and start a discussion about questions concerning their application.
Krchnák
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Selectide Corporation, Hoechst Marion Roussel, Tucson, AZ 85737, USA.
Lebl
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M
D001426:Bacterial Proteins; D001665:Binding Sites; D002625:Chemistry, Organic / Q000379:methods; D019020:Directed Molecular Evolution / Q000379:methods*; D015195:Drug Design; D004353:Drug Evaluation, Preclinical / Q000379:methods; D008024:Ligands; D015394:Molecular Structure; D012996:Solutions; D019809:Streptavidin
D001426:Bacterial Proteins; D008024:Ligands; D012996:Solutions; D019809:Streptavidin