title: Antibiotic exposure and its relationship to postantibiotic effect and bactericidal activity: constant versus exponentially decreasing tobramycin concentrations against Pseudomonas aeruginosa.
abstract: In vitro postantibiotic effects (PAEs) exhibited by a standard strain of Pseudomonas aeruginosa following exposure to tobramycin at constant concentrations were compared to those at exponentially decreasing concentrations. Exposure to a constant concentration showed more extensive bacterial killing and resulted in longer PAEs at comparable areas under the concentration-time curves above the MIC. This phenomenon suggests a significant contribution of pharmacokinetics to antimicrobial pharmacodynamics.
authors.affiliation: Department of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Shatin. ronli@cuhk.edu.hk
authors.forename: R C
authors.initials: RC
authors.lastname: Li
authors.forename: Z Y
authors.initials: ZY
authors.lastname: Zhu
authors.forename: S W
authors.initials: SW
authors.lastname: Lee
authors.forename: K
authors.initials: K
authors.lastname: Raymond
authors.forename: J M
authors.initials: JM
authors.lastname: Ling
authors.forename: A F
authors.initials: AF
authors.lastname: Cheng
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000494:pharmacology*; D002452:Cell Count; D008826:Microbial Sensitivity Tests; D011550:Pseudomonas aeruginosa / Q000187:drug effects*; D013997:Time Factors; D014031:Tobramycin / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D014031:Tobramycin