Role of different neurotransmitter systems in the cholecystokinin octapeptide-induced anxiogenic response in rats.
The possible involvement of different neurotransmitter systems in the anxiogenic action of cholecystokinin octapeptide sulphate ester (CCK-8) was investigated in rats. Intracerebroventricularly (i.c.v.) administered CCK-8 induced an anxiogenic response in an elevated plus-maze test. Pretreatment with dopaminergic, muscarinergic acetylcholine receptor blockers and an opiate receptor antagonist blocked the anxiogenic response to CCK-8. The alpha and beta adrenoreceptor, the GABA receptor and the 5-hydroxytryptamine (5-HT) receptor blockers were not able to modulate the 'anxiogenic-like' effect of CCK-8. The results suggest that the anxiogenic effects of CCK-8 are mediated via different neurotransmitters and the anxiogenic action can be prevented by receptor blockers to these transmitters.
Biró
E
E
Institute of Pathophysiology, Albert Szent-Györgyi Medical University, Szeged, Hungary.
Penke
B
B
Telegdy
G
G
D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000818:Animals; D001007:Anxiety / Q000139:chemically induced* / Q000188:drug therapy / Q000503:physiopathology; D001285:Atropine / Q000494:pharmacology; D001640:Bicuculline / Q000494:pharmacology; D018492:Dopamine Antagonists / Q000494:pharmacology; D018756:GABA Antagonists / Q000494:pharmacology; D006220:Haloperidol / Q000494:pharmacology; D007276:Injections, Intraventricular; D008297:Male; D008784:Methysergide / Q000494:pharmacology; D018727:Muscarinic Antagonists / Q000494:pharmacology; D009270:Naloxone / Q000494:pharmacology; D009292:Narcotic Antagonists / Q000494:pharmacology; D010643:Phenoxybenzamine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D012702:Serotonin Antagonists / Q000494:pharmacology; D012844:Sincalide / Q000494:pharmacology* / Q000502:physiology
D000317:Adrenergic alpha-Antagonists; D000319:Adrenergic beta-Antagonists; D018492:Dopamine Antagonists; D018756:GABA Antagonists; D018727:Muscarinic Antagonists; D009292:Narcotic Antagonists; D012702:Serotonin Antagonists; D010643:Phenoxybenzamine; D009270:Naloxone; D001285:Atropine; D011433:Propranolol; D006220:Haloperidol; D012844:Sincalide; D008784:Methysergide; D001640:Bicuculline