[The mechanisms of the stimulating effect of tissue basophils on the reparative processes in inflammation].
Mast cells stimulating effect on reparative processes in inflammation involves histamine, serotonin and heparin. This was shown on the model of E. coli-induced acute infectious peritonitis in rats using antagonists of major biologically active mast cells products (histamine, serotonin and heparin)-dimedrole, cimetidine, ciproheptadine and protamine sulfate. Fibroblast accumulation is associated with histamine, influencing predominantly H1- and H2-receptors as well as with serotonin. Fibroblast proliferative synthetic ability increases through histamine action on H1-receptors and serotonin and heparin influence. Accumulation of monocytes-macrophages and their proliferative synthetic ability stimulation is affected by histamine (through H1-receptors) and serotonin.
Klimenko
N A
NA
Tatarko
S V
SV
D000208:Acute Disease; D000818:Animals; D001345:Autoradiography; D004195:Disease Models, Animal; D004927:Escherichia coli Infections / Q000473:pathology / Q000503:physiopathology*; D006493:Heparin / Q000502:physiology; D006494:Heparin Antagonists / Q000494:pharmacology; D006632:Histamine / Q000502:physiology; D006633:Histamine Antagonists / Q000494:pharmacology; D008297:Male; D008407:Mast Cells / Q000187:drug effects / Q000473:pathology / Q000502:physiology*; D008643:Mesentery / Q000187:drug effects / Q000473:pathology; D010538:Peritonitis / Q000473:pathology / Q000503:physiopathology*; D051381:Rats; D012701:Serotonin / Q000502:physiology; D012702:Serotonin Antagonists / Q000494:pharmacology
D006494:Heparin Antagonists; D006633:Histamine Antagonists; D012702:Serotonin Antagonists; D012701:Serotonin; D006632:Histamine; D006493:Heparin
Mekhanizmy stimuliruiushchego vliianiia tkanevykh bazofilov na reparativnye protsessy pri vospalenii.