title: Lack of carcinogenesis by the baked mushroom Agaricus bisporus in mice: different feeding regimen [corrected].
abstract: Agaricus bisporus, the cultivated mushroom of the western hemisphere, was baked at 220-230 degrees C for 10 minutes and subsequently fed to mice for 12 hours each day, five days each week throughout their life. After each feeding cycle, the animals received a well-balanced semisynthetic diet for 12 hours each day for five days plus the remaining two full days each week. The estimated average daily mushroom consumption per animal was 4.8 g for a female and 4.2 g for a male. Randomly bred Swiss mice, six weeks old at the start of the experiment, were used. In the baked mushroom-fed group, the incidences of tumors in the lungs, blood vessels, cecum, and colon increased when compared to the untreated controls. These increases were not, however, statistically significant. In another previous experiment, both the raw and the baked mushrooms, when used in different feeding regimens, induced statistically significant incidences of cancers in several organs of the mice. It is possible that the negative finding in the current study was due to insufficient mushroom consumption.
authors.affiliation: Eppley Institute for Research in Cancer, University of Nebraska Medical Center, Omaha 68198, USA.
authors.forename: B
authors.initials: B
authors.lastname: Toth
authors.forename: J
authors.initials: J
authors.lastname: Erickson
authors.forename: P
authors.initials: P
authors.lastname: Gannett
mesh_terms: D000230:Adenocarcinoma / Q000401:mortality; D000236:Adenoma / Q000401:mortality; D000364:Agaricus; D000821:Animal Feed; D000818:Animals; D002273:Carcinogens / Q000494:pharmacology*; D002430:Cecal Neoplasms / Q000401:mortality; D003110:Colonic Neoplasms / Q000401:mortality; D004032:Diet; D005260:Female; D006391:Hemangioma / Q000401:mortality; D008175:Lung Neoplasms / Q000401:mortality; D008297:Male; D051379:Mice; D012513:Sarcoma, Experimental / Q000401:mortality; D016019:Survival Analysis; D019043:Vascular Neoplasms / Q000401:mortality
chemical_list: D002273:Carcinogens