Cardiac surgery and plasma digoxin levels.
Cardiopulmonary bypass (CPB) can induce several haemodynamic alterations and therefore influence pharmacokinetics of various drugs. In order to assess the effect of CPB on plasma digoxin levels, these were monitored in patients undergoing open heart surgery involving CPB (n = 11), over a 24 hour period, starting just prior to commencement of surgery. For comparison, plasma digoxin was also monitored in a group of patients (n = 10) who underwent cardiac surgery not involving CPB. In 7 of the 11 patients in the CPB group, plasma digoxin levels (ng/ml) were significantly (p < 0.01) lower at the end of 24 hours (0.654 +/- 0.094) than basal levels (1.3114 +/- 0.2498). In contrast, in the non CPB group, 7 of 10 patients showed significantly higher (p < 0.001) plasma levels (ng/ml) at the end of 24 hours (0.477 +/- 0.125) as compared to basal levels (0.26 +/- 0.098). Thus, rather than the type of surgery, it appears that the pre-operative levels of plasma digoxin influence its pharmacokinetics.
Anaokar
S M
SM
Department of Pharmacology, Seth GS Medical College, Mumbai, India.
Thorat
S P
SP
Tendolkar
A G
AG
Mukadam
M E
ME
Dahanukar
S A
SA
Thatte
U M
UM
D000328:Adult; D002315:Cardiopulmonary Bypass; D002316:Cardiotonic Agents / Q000097:blood* / Q000627:therapeutic use; D016022:Case-Control Studies; D004077:Digoxin / Q000097:blood* / Q000627:therapeutic use; D005260:Female; D006350:Heart Valve Prosthesis; D006801:Humans; D008297:Male; D008943:Mitral Valve / Q000601:surgery*; D008944:Mitral Valve Insufficiency / Q000601:surgery; D008946:Mitral Valve Stenosis / Q000601:surgery; D012214:Rheumatic Heart Disease / Q000601:surgery*; D013997:Time Factors
D002316:Cardiotonic Agents; D004077:Digoxin