Endothelin-1: possible implications in pulmonary vascular disease.
The vasoactive properties of endothelin-1 (ET-1) in the animal model very with the tone of the pulmonary vessels, the dose level of ET-1, and the maturation of the vessels. The action of ET-1 is mediated by endothelium-derived nitric oxide, prostaglandins, and electrolytes. Plasma levels of ET-1 are elevated in pulmonary hypertension in both animals and humans. ET-1 antagonists may prove useful in treating pulmonary hypertension in children and adults.
Angerio
A D
AD
Department of Physiology and Biophysics, Georgetown University Medical Center, Washington, DC 20007, USA.
Kot
P A
PA
D000818:Animals; D004195:Disease Models, Animal; D019332:Endothelin-1 / Q000502:physiology*; D006801:Humans; D006976:Hypertension, Pulmonary / Q000097:blood; D011652:Pulmonary Circulation / Q000502:physiology
D019332:Endothelin-1