Combination of subtotal perineoplasty and interferon for the treatment of vulvar vestibulitis.
OBJECTIVE
To evaluate the efficacy of a combination of subtotal perineoplasty and interferon (IFN) infiltration of the remaining anterior vestibule in the treatment of vulvar vestibulitis.


METHODS
Nineteen women with vulvar vestibulitis were randomized to undergo either a total perineoplasty or a subtotal perineoplasty without removal of the anterior vestibule. The second group was further treated 6 weeks later with injection of the anterior vestibule by IFN. Differences in outcome between the groups were analyzed using Fisher's exact test.


RESULTS
The combination of subtotal perineoplasty and IFN injections was successful in 7 of 10 women, similar to the outcome of the group undergoing total perineoplasty (6 of 9 patients).


CONCLUSIONS
A combination of subtotal perineoplasty and IFN injections to the anterior vestibule is as effective as total perineoplasty and has less surgical complications.
Bornstein
J
J
Department of Obstetrics and Gynecology, Carmel Medical Center and the Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa. mdjacob@tx.technion.ac.il
Abramovici
H
H
D000293:Adolescent; D000328:Adult; D003131:Combined Modality Therapy; D004414:Dyspareunia / Q000209:etiology / Q000628:therapy; D005260:Female; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000008:administration & dosage / Q000627:therapeutic use*; D011994:Recombinant Proteins; D016896:Treatment Outcome; D014847:Vulvitis / Q000150:complications / Q000601:surgery / Q000628:therapy*
D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins