Glutathione S-transferase theta genetic polymorphism might influence tacrine hepatotoxicity in Alzheimer's patients.
Becquemont
L
L
Clinical Pharmacology Unit, Saint Antoine University Hospital, School of Medicine Paris 6, France. christian.funck-brentano@sau.ap-hop-paris-fr
Lecoeur
S
S
Simon
T
T
Beaune
P
P
Funck-Brentano
C
C
Jaillon
P
P
D000368:Aged; D000410:Alanine Transaminase / Q000097:blood; D000544:Alzheimer Disease / Q000188:drug therapy / Q000235:genetics*; D056486:Chemical and Drug Induced Liver Injury; D005838:Genotype; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012307:Risk Factors; D013619:Tacrine / Q000009:adverse effects*
D013619:Tacrine; D005982:Glutathione Transferase; D000410:Alanine Transaminase