title: Localization of tissue inhibitor of metalloproteinases-3 in neurodegenerative retinal disease.
abstract: Tissue inhibitor of metalloproteinases-3 (TIMP-3) is one of a family of genes whose products are implicated in the regulation of remodelling of the extracellular matrix. The level of mRNA coding for TIMP-3 is increased in retinas affected by the photoreceptor degenerative disease, simplex retinitis pigmentosa (RP), and mutations in TIMP-3 are associated with an inherited form of macular dystrophy. Here we compare TIMP-3 protein expression in normal retina and in those affected by RP and by age-related macular degeneration. Immunoreactive TIMP-3 is present in normal retinal pigment epithelium, and in degenerative retinas particularly at Bruch's membrane and additionally in photoreceptor-retaining regions in simplex RP. The pattern suggests a role for TIMP-3 in normal retinal homeostasis, and, in the disease state, in the modulation of extracellular matrix metabolism and neovascularization.
authors.affiliation: British Retinitis Pigmentosa Society Laboratory, Department of Pharmacology, UMDS, Rayne Institute, St Thomas' Hospital, London, UK.
authors.forename: C
authors.initials: C
authors.lastname: Jomary
authors.forename: M J
authors.initials: MJ
authors.lastname: Neal
authors.forename: K
authors.initials: K
authors.lastname: Iwata
authors.forename: S E
authors.initials: SE
authors.lastname: Jones
mesh_terms: D000368:Aged; D000911:Antibodies, Monoclonal; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D011480:Protease Inhibitors / Q000378:metabolism*; D011506:Proteins / Q000378:metabolism*; D012162:Retinal Degeneration / Q000378:metabolism*; D019717:Tissue Inhibitor of Metalloproteinase-3
chemical_list: D000911:Antibodies, Monoclonal; D011480:Protease Inhibitors; D011506:Proteins; D019717:Tissue Inhibitor of Metalloproteinase-3