title: A new treatment with bleomycin for complicated cutaneous hemangioma in children.
abstract: Cutaneous hemangiomas are the most common tumors of infants and children. Although they frequently resolve spontaneously, approximately 5% produce complications such as bleeding, infection, consumption coagulopathy and unesthetic appearance. Various methods of treatment are described for these complicated hemangiomas. We used a new type of treatment for complicated cutaneous hemangiomas as intralesional bleomycin (BLM) injection, for the first time in the literature. This agent produced extensive fibrosis and spontaneous resolution of hemangiomas. Fourteen patients with complicated hemangiomas (twelve capillary and two cavernous) have been treated with this method during a three-years period. Of these fourteen patients, five had bleeding, three had infection, one had ulceration, and five had unesthetic appearance and continued rapid growth. Lesions of three patients were completely excised after only one BLM injection. In the other eleven patients lesions regressed 60-100% during 6-14 months with two to three BLM injections. We believe that intralesional BLM injection is simple, and very useful for treatment of complicated cutaneous hemangiomas.
authors.affiliation: Department of Pediatric Surgery, University Hospital Trabzon, Turkey.
authors.forename: H
authors.initials: H
authors.lastname: Sarihan
authors.forename: H
authors.initials: H
authors.lastname: Mocan
authors.forename: K
authors.initials: K
authors.lastname: Yildiz
authors.forename: M
authors.initials: M
authors.lastname: Abes
authors.forename: R
authors.initials: R
authors.lastname: Akyazici
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage*; D001761:Bleomycin / Q000008:administration & dosage*; D017024:Chemotherapy, Adjuvant; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006391:Hemangioma / Q000150:complications / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D018324:Hemangioma, Capillary / Q000188:drug therapy / Q000473:pathology / Q000601:surgery; D006392:Hemangioma, Cavernous / Q000188:drug therapy / Q000473:pathology / Q000601:surgery; D006801:Humans; D007223:Infant; D015552:Injections, Intralesional; D008297:Male; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000150:complications / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery
chemical_list: D000903:Antibiotics, Antineoplastic; D001761:Bleomycin