Failure of absorption of baclofen after rectal administration.
We wished to determine the degree to which baclofen was absorbed from an aqueous vehicle after rectal administration. A comparison was made to absorption after oral administration. After oral administration, the baclofen half-life was 2.3 to 3.4 hours and peak serum concentrations were achieved from 1 to 2.1 hours after administration. No measurable absorption was observed after rectal administration of the drug in any subject. Rectal administration of baclofen is not a clinically sound treatment option when oral administration of the drug is not possible. For patients receiving chronic baclofen therapy, other medications such as a benzodiazepine should be considered at times when oral administration of medication is not possible.
Kriel
R L
RL
Department of Neurology, Hennepin County Medical Center, Minneapolis, MN 55415, USA.
Krach
L E
LE
Hoff
D S
DS
Gormley
M
M
Jones-Saete
C
C
D000042:Absorption / Q000502:physiology; D000284:Administration, Oral; D000285:Administration, Rectal; D000328:Adult; D001418:Baclofen / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D017211:Treatment Failure
D001418:Baclofen