Central nervous system resuscitation.
Traumatic injury to the central nervous system induces delayed neuronal death, which may be mediated by acute and chronic neurochemical changes. Experimental identification of these injury mechanisms and elucidation of the neurochemical cascade following trauma may provide enhanced opportunities for treatment with novel neuroprotective strategies.
McIntosh
T K
TK
Department of Neurosurgery, Bioengineering, and Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, USA.
Garde
E
E
Saatman
K E
KE
Smith
D H
DH
D000818:Animals; D001930:Brain Injuries / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D002121:Calcium Channel Blockers / Q000627:therapeutic use; D002154:Calpain / Q000037:antagonists & inhibitors; D016207:Cytokines / Q000037:antagonists & inhibitors; D004630:Emergencies; D018691:Excitatory Amino Acid Antagonists / Q000627:therapeutic use; D006801:Humans; D009414:Nerve Growth Factors / Q000627:therapeutic use; D018696:Neuroprotective Agents / Q000494:pharmacology / Q000627:therapeutic use*; D012151:Resuscitation / Q000379:methods
D002121:Calcium Channel Blockers; D016207:Cytokines; D018691:Excitatory Amino Acid Antagonists; D009414:Nerve Growth Factors; D018696:Neuroprotective Agents; D002154:Calpain