[The efficacy of the magnesium sulfate aerosol treatment of bronchial asthma patients].
Action of magnesium sulphate (MS) aerosol (solution osmolality 260 mmol/l, pH 6.6) on bronchial sensitivity and reactivity to acetylcholine(AC) and graded exercise as well as bronchial permeability assessed by general plethysmography and pneumotaxography were studied in 49 patients with mild and moderate bronchial asthma. It is shown that when compared to placebo, MS inhalations conducted in the time of attenuating asthma exacerbation improved immediate and long-term responses in atopic and effort asthma. Both in single doses and course administration MS reduced non-specific bronchial hyperreactivity and secretory activity of mast cells. Positive dynamics of bronchoprovocative AC test suggested response to treatment in most BA patients.
Emel'ianov
A V
AV
Goncharova
V A
VA
Sinitsina
T M
TM
D000280:Administration, Inhalation; D000293:Adolescent; D000328:Adult; D000336:Aerosols; D018927:Anti-Asthmatic Agents / Q000008:administration & dosage*; D001249:Asthma / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology; D016535:Bronchial Hyperreactivity / Q000175:diagnosis / Q000188:drug therapy; D001985:Bronchial Provocation Tests / Q000379:methods; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008278:Magnesium Sulfate / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged
D000336:Aerosols; D018927:Anti-Asthmatic Agents; D008278:Magnesium Sulfate
Effektivnost' lecheniia aérozolom sul'fata magniia bol'nykh bronkhial'noĭ astmoĭ.