title: [Cerebral cytochrome oxidase monitoring by near infrared spectroscopy during selective cerebral perfusion].
abstract: To evaluate selective cerebral perfusion (SCP) for brain protection, the redox state of cytochrome oxidase (Cyt. aa3) in brain tissue were studied in 27 patients with thoracic aortic repair. The redox state of Cyt. aa3 was monitored by near infrared spectroscopy (NIRS) (OM-110, Shimazu). There were no significant changes in the Cyt. aa3 redox state in 13 (Group I), the oxidation state of Cyt. aa3 decreased then recovered to control levels in 12 (Group II), and the oxidation state decreased but did not recover in 2 patients (Group III). Postoperative cerebral damage was observed in 5 patients; blindness occurred in one patient in Group I (8.3%), 2 patients developed hemiplegia in Group II (15.4%), and the 2 patients in Group III failed to reawaken (100%). The incidence of cerebral damage was significantly higher in Group III than in Groups I and II (p < 0.05). We conclude that monitoring the redox state of Cyt. aa3 using NIRS is useful in predicting postoperative cerebral damage. However, it is necessary to increase the number of measurement sites since NIRS can reflect the state in only a small area of the brain.
authors.affiliation: Second Department of Surgery, Kagoshima University Faculty of Medicine, Japan.
authors.forename: G
authors.initials: G
authors.lastname: Yotsumoto
authors.forename: H
authors.initials: H
authors.lastname: Toyohira
authors.forename: Y
authors.initials: Y
authors.lastname: Moriyama
authors.forename: S
authors.initials: S
authors.lastname: Watanabe
authors.forename: Y
authors.initials: Y
authors.lastname: Iguro
authors.forename: H
authors.initials: H
authors.lastname: Masuda
authors.forename: K
authors.initials: K
authors.lastname: Hisatomi
authors.forename: S
authors.initials: S
authors.lastname: Shimokawa
authors.forename: A
authors.initials: A
authors.lastname: Taira
mesh_terms: D000368:Aged; D000784:Aortic Dissection / Q000201:enzymology / Q000601:surgery; D001013:Aorta, Thoracic / Q000601:surgery; D017545:Aortic Aneurysm, Thoracic / Q000201:enzymology / Q000601:surgery; D001921:Brain / Q000201:enzymology*; D002560:Cerebrovascular Circulation; D003576:Electron Transport Complex IV / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic; D010477:Perfusion; D019265:Spectroscopy, Near-Infrared
chemical_list: D003576:Electron Transport Complex IV