title: The behavior of endometrial hyperplasia: a prospective study. Endometrial Hyperplasia Study Group.
abstract: OBJECTIVE
  To clarify the behavior of endometrial hyperplasia in a prospective study.
  
  
  METHODS
  Fifty-one patients with endometrial hyperplasia were followed up for 6 months. Samples of endometrial tissues were taken by uterine endometrial biopsy every 4 weeks during the first 3 months and at the end of follow-up.
  
  
  RESULTS
  In 69% (35/51) of the patients histological picture of the endometrium became normal during the observation period. The lesions persisted in 17% (6/35) of the patients with simple hyperplasia, in 25% (1/4) of those with complex hyperplasia, in 14% (1/7) of those with simple atypical hyperplasia, and in 80% (4/5) of the patients with complex atypical hyperplasia. In the remaining 3 patients with simple hyperplasia, the lesions progressed to complex atypical hyperplasia by the end of follow-up, after showing a normal endometrium.
  
  
  CONCLUSIONS
  Most cases of endometrial hyperplasia, except for complex atypical hyperplasia, disappeared spontaneously within a short period of time.
authors.affiliation: Department of Obstetrics and Gynecology, Tottori University School of Medicine, Yonago, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Terakawa
authors.forename: J
authors.initials: J
authors.lastname: Kigawa
authors.forename: Y
authors.initials: Y
authors.lastname: Taketani
authors.forename: H
authors.initials: H
authors.lastname: Yoshikawa
authors.forename: A
authors.initials: A
authors.lastname: Yajima
authors.forename: K
authors.initials: K
authors.lastname: Noda
authors.forename: H
authors.initials: H
authors.lastname: Okada
authors.forename: J
authors.initials: J
authors.lastname: Kato
authors.forename: M
authors.initials: M
authors.lastname: Yakushiji
authors.forename: O
authors.initials: O
authors.lastname: Tanizawa
authors.forename: S
authors.initials: S
authors.lastname: Fujimoto
authors.forename: S
authors.initials: S
authors.lastname: Nozawa
authors.forename: T
authors.initials: T
authors.lastname: Takahashi
authors.forename: K
authors.initials: K
authors.lastname: Hasumi
authors.forename: N
authors.initials: N
authors.lastname: Furuhashi
authors.forename: T
authors.initials: T
authors.lastname: Aono
authors.forename: A
authors.initials: A
authors.lastname: Sakamoto
authors.forename: M
authors.initials: M
authors.lastname: Furusato
mesh_terms: D000328:Adult; D001706:Biopsy; D004714:Endometrial Hyperplasia / Q000473:pathology*; D004717:Endometrium / Q000473:pathology; D005260:Female; D006801:Humans; D008875:Middle Aged; D017698:Postmenopause; D017697:Premenopause; D011446:Prospective Studies; D012075:Remission, Spontaneous