title: Treatment of metastatic uterine leiomyosarcoma with cisplatin, pirarubicin, and ifosfamide.
abstract: We present the unusual case of a 27-year-old Japanese woman who exhibited recurrences of metastatic tumors from uterine leiomyosarcoma after five operations. Chemotherapy with cisplatin, pirarubicin, and cyclophosphamide was ineffective. Substituting ifosfamide for cyclophosphamide, we obtained a complete response. The Gynecologic Oncology Group (GOG) in the United States has recognized the efficacy of ifosfamide and mesna in the treatment of patients with advanced or recurrent uterine sarcomas. Here we report on the efficacy of ifosfamide in addition to cisplatin and pirarubicin.
authors.affiliation: Department of Obstetrics and Gynecology, Oita Medical University, Hasama, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Hirota
authors.forename: K
authors.initials: K
authors.lastname: Miyamura
authors.forename: T
authors.initials: T
authors.lastname: Hayata
authors.forename: I
authors.initials: I
authors.lastname: Miyakawa
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002945:Cisplatin / Q000008:administration & dosage*; D004317:Doxorubicin / Q000008:administration & dosage / Q000031:analogs & derivatives*; D005260:Female; D006801:Humans; D007069:Ifosfamide / Q000008:administration & dosage*; D007166:Immunosuppressive Agents; D007890:Leiomyosarcoma / Q000188:drug therapy* / Q000473:pathology; D009364:Neoplasm Recurrence, Local; D012074:Remission Induction; D014594:Uterine Neoplasms / Q000188:drug therapy* / Q000473:pathology
chemical_list: D007166:Immunosuppressive Agents; D004317:Doxorubicin; C027260:pirarubicin; D002945:Cisplatin; D007069:Ifosfamide