title: Haemostatic parameters in patients with primitive venous hypertension.
abstract: In twenty patients with primitive venous hypertension and in ten healthy subjects we have determined the plasmatic levels of: Thrombomodulin (TM), beta-Thromboglobulin (beta-TG), D-Dimer (DD), the tissue activator of the plasminogen (t-PA) and the inhibitor of the activator of the plasminogen (PAI-1). The levels of the parameter we studied have shown in the patients a significant difference of beta-TG (p < 0.01) and PAI-1 (p < 0.01) compared to the controls, whereas there was no significant difference in the other parameters we studied. Our data underline, in patients with primitive venous hypertension, the importance that the activation of the platelets and the reduction of the potential fibrinolytic can assume, together with the stasis, regarding the onset of thrombotic complications.
authors.affiliation: Chair of Angiology, Department of Internal Medicine, University of Messina, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Trifiletti
authors.forename: R
authors.initials: R
authors.lastname: Scamardi
authors.forename: M A
authors.initials: MA
authors.lastname: Pizzoleo
authors.forename: A
authors.initials: A
authors.lastname: Nevoso
authors.forename: A
authors.initials: A
authors.lastname: Attina
authors.forename: S
authors.initials: S
authors.lastname: Soraci
authors.forename: L
authors.initials: L
authors.lastname: Bagnato
authors.forename: N
authors.initials: N
authors.lastname: Barbera
mesh_terms: D000328:Adult; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis; D005342:Fibrinolysis / Q000502:physiology; D006487:Hemostasis / Q000502:physiology*; D006801:Humans; D008297:Male; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood; D018180:Thrombomodulin / Q000097:blood; D010959:Tissue Plasminogen Activator / Q000097:blood; D014690:Venous Pressure / Q000502:physiology*; D001620:beta-Thromboglobulin / Q000032:analysis
chemical_list: D005338:Fibrin Fibrinogen Degradation Products; D017395:Plasminogen Activator Inhibitor 1; D018180:Thrombomodulin; D001620:beta-Thromboglobulin; C036309:fibrin fragment D; D010959:Tissue Plasminogen Activator