title: Estrogen or testosterone increases self-reported aggressive behaviors in hypogonadal adolescents.
abstract: A randomized, double-blinded, placebo-controlled cross-over clinical trial was used to determine the role of sex steroids on the development of aggressive behaviors in 35 boys and 14 girls. Depo-testosterone (to boys) or conjugated estrogens (to girls) was administered in 3-month blocks alternating with placebo at three dose levels approximating early, middle and late pubertal amounts. The Olweus Multifaceted Aggression Inventory was administered after each placebo and treatment period to ascertain the effect of sex steroids on self-reported aggressive behaviors. We employed a strict intent-to-treat analytical model. The data demonstrated significant hormone effects on physical aggressive behaviors and aggressive impulses, but not in verbal aggressive behaviors nor aggressive inhibitions in both boys and girls. These results are the first to causally relate the administration of physiological doses of sex steroids to changes in aggressive behaviors in adolescents.
authors.affiliation: Department of Pediatrics, Pennsylvania State University, College of Medicine, Hershey 16802, USA. jwf3@psu.edu
authors.forename: J W
authors.initials: JW
authors.lastname: Finkelstein
authors.forename: E J
authors.initials: EJ
authors.lastname: Susman
authors.forename: V M
authors.initials: VM
authors.lastname: Chinchilli
authors.forename: S J
authors.initials: SJ
authors.lastname: Kunselman
authors.forename: M R
authors.initials: MR
authors.lastname: D'Arcangelo
authors.forename: J
authors.initials: J
authors.lastname: Schwab
authors.forename: L M
authors.initials: LM
authors.lastname: Demers
authors.forename: L S
authors.initials: LS
authors.lastname: Liben
authors.forename: G
authors.initials: G
authors.lastname: Lookingbill
authors.forename: H E
authors.initials: HE
authors.lastname: Kulin
mesh_terms: D000293:Adolescent; D000328:Adult; D000374:Aggression / Q000187:drug effects*; D002648:Child; D018592:Cross-Over Studies; D004311:Double-Blind Method; D004966:Estrogens, Conjugated (USP) / Q000494:pharmacology* / Q000627:therapeutic use; D004970:Estrone / Q000031:analogs & derivatives / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007006:Hypogonadism / Q000188:drug therapy*; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D010919:Placebos; D013739:Testosterone / Q000097:blood / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D004966:Estrogens, Conjugated (USP); D010919:Placebos; D004970:Estrone; D013739:Testosterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; C017296:estrone sulfate