title: [Serotonergic function in endogeneity of depression].
abstract: OBJECTIVE
  This study employed an alternative method for assessing serotonergic function in depression. The neuroendocrine responses to acute intravenous administration of the serotonin (5-HT) reuptake inhibitor clomipramine were assessed in patients with Major Depression with Melancholia (DMM) and matched subjects with Major Depression (DM) (without Melancholia) and Dysthimic disorder (TD).
  
  
  METHODS
  10 patients who met DSM III-R criteria of DMM, 10 patients with DM and 10 with DD matched for age and sex received 12.5 mg of intravenously administered clomipramine. Prl, Cortisol and GH were measured during the next 135 minutes. We divided the samples using the Newcastle Scale.
  
  
  RESULTS
  The DMM patients had significant blunting prolactin responses to clomipramine compared with the other patients. Most of the major depression patients without melancholia were neurotic depressions according to the Newcastle Scale. There was a negative correlation between endogeneity and prolactin response.
  
  
  CONCLUSIONS
  These data support the hypothesis that DMM patients have abnormal neuroendocrine responses to the intravenous administration of the 5-HT reuptake inhibitor clomipramine, and that there is an association between endogeneity and prolactin response.
authors.affiliation: Hospital Santiago Apóstol. Vitoria.
authors.forename: A
authors.initials: A
authors.lastname: González-Pinto
authors.forename: J J
authors.initials: JJ
authors.lastname: López-Ibor
authors.forename: J
authors.initials: J
authors.lastname: Sáiz
authors.forename: M
authors.initials: M
authors.lastname: Gutiérrez
authors.forename: J L
authors.initials: JL
authors.lastname: Figuerido
authors.forename: E
authors.initials: E
authors.lastname: Elizagárate
authors.forename: J L
authors.initials: JL
authors.lastname: Pérez de Heredia
mesh_terms: D000328:Adult; D000368:Aged; D002997:Clomipramine; D003866:Depressive Disorder / Q000503:physiopathology* / Q000523:psychology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D012701:Serotonin / Q000502:physiology*; D017367:Selective Serotonin Reuptake Inhibitors
chemical_list: D002997:Clomipramine; D012701:Serotonin; D017367:Selective Serotonin Reuptake Inhibitors
vernacular_title: Función serotoninérgica y endogeneidad en la depresión.