title: Antibiotic resistance study of invasive S.pneumoniae.
abstract: 121 invasive pneumococci isolated from meningitis, septicemia, pneumopathies and other clinical infections (osteo-arthritis, peritonitis, sinusitis, otilis, conjunctivitis, plagues) were screened for susceptibility to penicillin G (P), erythromycim (E), chloramphenicol (Cl), tetracycline (T), ceftriaxone (Cro), and sulfametoxazole trimethoprim (SxT) by diffusimetric method, by MICs to P and Cro by agar dilutions and E-test. 48.8% were penicillin resistant (MICs > 0.12 microgram/ml), 22.7% being highly resistant (MICs 3-8 micrograms/ml). Any strain was resistant to P only, but patterns with P included were frequent (55.8%). Resistance to SxT was highest (monoresistance 25.6% as well as polyresistance 69.8%). 72.9% were resistant strains to > or = 1 antibiotic with 12 patterns of resistance (1-5 antibiotics). All of the strains were susceptible to Cro (MICs-0.003-0.5 microgram/ml). Resistance was closely correlated to serotypes 6,9,14,19,23 to site of isolation and diagnosis. Pneumococci from meningitis were 2-3 times more susceptible to P,E,Cl,T and SxT than the isolates from pneumopathies or other infections.
authors.affiliation: Cantacuzino Institute, Bucharest, Romania.
authors.forename: F
authors.initials: F
authors.lastname: Mihalcu
authors.forename: M
authors.initials: M
authors.lastname: Pană
authors.forename: D
authors.initials: D
authors.lastname: Burcea
authors.forename: I
authors.initials: I
authors.lastname: Mitache
authors.forename: G
authors.initials: G
authors.lastname: Coman
mesh_terms: D002443:Ceftriaxone / Q000494:pharmacology / Q000627:therapeutic use; D002511:Cephalosporins / Q000494:pharmacology / Q000627:therapeutic use; D004352:Drug Resistance, Microbial; D018432:Drug Resistance, Multiple; D006801:Humans; D008826:Microbial Sensitivity Tests; D012383:Romania; D013290:Streptococcal Infections / Q000188:drug therapy / Q000382:microbiology; D013296:Streptococcus pneumoniae / Q000187:drug effects* / Q000302:isolation & purification
chemical_list: D002511:Cephalosporins; D002443:Ceftriaxone