Biomarkers of gene expression: growth factors and oncoproteins.
This article reviews the literature on the application of methods for the detection of growth factors, oncogene proteins, and tumor-suppressor gene proteins in the blood of humans with cancer or who are at risk for the development of cancer. The research summarized here suggests that many of these biomarker assays can be used to distinguish between diseased and nondiseased states and in some instances may be able to predict susceptibility for future disease. Thus, these biomarkers could be valuable tools for monitoring at-risk populations for purposes of disease prevention and control.
Brandt-Rauf
P W
PW
Division of Environmental Health Sciences, Columbia University School of Public Health, New York, New York 10032, USA.
D015415:Biomarkers; D015870:Gene Expression; D006133:Growth Substances / Q000097:blood*; D006801:Humans; D009369:Neoplasms / Q000097:blood*; D017978:Receptors, Growth Factor / Q000097:blood*; D016159:Tumor Suppressor Protein p53 / Q000097:blood*
D015415:Biomarkers; D006133:Growth Substances; D017978:Receptors, Growth Factor; D016159:Tumor Suppressor Protein p53