title: Tumoural portal vein thrombosis. Enhancement with MnDPDP.
abstract: OBJECTIVE
  Intrahepatic thrombus is usually associated with either cirrhosis or hepatocellular carcinoma (HCC). Most HCCs enhance after the administration of MnDPDP (Teslascan). Our objective was to analyze the enhancement characteristics of tumour portal vein thrombi.
  
  
  METHODS
  Thrombi affecting the main or segmental portal veins (17 cases) and the suprahepatic inferior vena cava (1 case) were retrospectively selected from a series of 128 patients studied with MR imaging before and after the administration of MnDPDP. Enhancement was assessed qualitatively and quantitatively.
  
  
  RESULTS
  All tumour thrombi enhanced after MnDPDP administration. The enhancement was more conspicuous in the GRE images. On the quantitative evaluation, the portal thrombus enhancement was greater for GRE images than SE images. Portal thrombi enhanced more than the liver and the HCCs. There was a significant difference between the enhancement of the HCCs and the thrombi with both MR imaging techniques.
  
  
  CONCLUSIONS
  The greater enhancement of the tumour thrombus associated with the liver and HCC may suggest that other mechanisms, apart from accumulation of the contrast medium within the hepatocytes inside the thrombi, are involved in thrombus enhancement.
authors.affiliation: Department of Radiology, Dr. Peset Hospital, Valencia, Spain. bonmati@san.gva.es
authors.forename: L
authors.initials: L
authors.lastname: Marti-Bonmati
authors.forename: E
authors.initials: E
authors.lastname: Lonjedo
authors.forename: D
authors.initials: D
authors.lastname: Mathieu
authors.forename: C
authors.initials: C
authors.lastname: Coffin
authors.forename: C
authors.initials: C
authors.lastname: Poyatos
authors.forename: M C
authors.initials: MC
authors.lastname: Anglade
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D006528:Carcinoma, Hepatocellular / Q000150:complications / Q000175:diagnosis; D003287:Contrast Media; D004492:Edetic Acid / Q000031:analogs & derivatives*; D005260:Female; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications / Q000175:diagnosis; D008113:Liver Neoplasms / Q000150:complications / Q000175:diagnosis; D008279:Magnetic Resonance Imaging / Q000295:instrumentation / Q000379:methods*; D008297:Male; D008345:Manganese; D008875:Middle Aged; D009360:Neoplastic Cells, Circulating / Q000473:pathology*; D011169:Portal Vein / Q000473:pathology*; D011732:Pyridoxal Phosphate / Q000031:analogs & derivatives*; D013927:Thrombosis / Q000175:diagnosis* / Q000209:etiology
chemical_list: D003287:Contrast Media; D008345:Manganese; D011732:Pyridoxal Phosphate; D004492:Edetic Acid; C060076:N,N'-bis(pyridoxal-5-phosphate)ethylenediamine-N,N'-diacetic acid