title: [First line chemotherapy of epithelial cancers of the ovary].
abstract: Treatment of epithelial ovarian cancer is based mainly on surgery and chemotherapy. Indications of chemotherapy depends on stage of disease and tumor histology. Initial polychemotherapy must be a platinum compound based regimen with respect of dose-intensity. Up to now the initial standard chemotherapy is a cyclophosphamide and platinum combination. Only one randomized study comparing cisplatin-cyclophosphamide and cisplatin-Taxol has been published in patients with macroscopic residual disease (> 1 cm). The improvement of survival with Taxol has led to propose this association as standard treatment in the USA and in some European countries. The place and role of anthracyclines are discussed. New drugs (topotecan, Oxaliplatine) and new modalities of administration (intensification, intraperitoneal route) are currently under evaluation.
authors.affiliation: Institut Gustave-Roussy, Viliejuif.
authors.forename: C
authors.initials: C
authors.lastname: Lhommé
authors.forename: P
authors.initials: P
authors.lastname: Pautier
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002277:Carcinoma / Q000188:drug therapy* / Q000473:pathology; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000473:pathology; D017671:Platinum Compounds / Q000008:administration & dosage
chemical_list: D017671:Platinum Compounds
vernacular_title: Chimiothérapie de première ligne des cancers épithéliaux de l'ovaire.