title: [Urinary calcium excretion. (Normal values for urinary calcium/creatinine ratio in Hungary). Multicenter study].
abstract: Metabolic bone disorders have attracted increasing attention in Hungary due to their significant impact on public health care. Measuring urinary calcium excretion is the first step in the biochemical assessment of bone metabolism. Fasting urinary calcium corrected by creatinine excretion is widely used all over the world. The aim of the present study was to establish standard methods and normal values for the calcium/creatinine ratio in Hungary. Twenty-four centers specializing in metabolic bone diseases participated in the study. Urine standards were sent out to these centers for calcium and creatine determinations. Based on the collected data, methods were corrected in order to achieve similar results for the standards. In the second phase of the study, the normal values for calcium/creatinine ratio were determined in SI units based on the data from 1846 healthy subjects (age 20-80 yrs) including 944 females and 902 males. The normal value for females was 0.438 +/- 0.391 (means +/- SD), and 0.395 +/- 0.352 for males, respectively (p < 0.03). The ratio increased with age in both sexes. The highest values were observed between 60-64 years in women and 70-74 years in men, respectively. After this peak, the calcium/creatinine ratio decreased. The values before and after 45 years of age were significantly different both in women (0.37 +/- 0.36, vs. 0.52 +/- 0.41, p < 0.001; and men (0.32 +/- 0.23, vs. 0.47 +/- 0.45, p < 0.001). The use of this distinction is recommended in the everyday practice.
authors.affiliation: Semmelweis Orvostudományi Egyetem, I., Belklinika Budapest.
authors.forename: P
authors.initials: P
authors.lastname: Lakatos
authors.forename: I
authors.initials: I
authors.lastname: Takács
authors.forename: B
authors.initials: B
authors.lastname: Büki
authors.forename: J
authors.initials: J
authors.lastname: Németh
authors.forename: C
authors.initials: C
authors.lastname: Horváth
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002118:Calcium / Q000652:urine*; D003404:Creatinine / Q000652:urine*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D012737:Sex Factors
chemical_list: D003404:Creatinine; D002118:Calcium
vernacular_title: A kalciumürítés vizsgálata. (A vizelet kalcium/kreatinin hányadosának magyarországi normálértékei). Multicentrikus tanulmány.