title: The effect of tamol on human mast cell chymase and plasmin.
abstract: Tamol is widely used in the therapy of inflammatory dermatoses. It has pronounced astringent properties and is able to inactivate the neutrophil-derived elastase. Since plasminogen activation and release of mast cell chymase may occur in acute dermatitis, we investigated the inhibitory properties of tamol for these enzymes. Tamol proved to be a potent inhibitor of plasmin and mast cell chymase in concentrations relevant for use in dermatotherapy. The inhibition of mast cell chymase and plasmin by tamol was linear and non-competitive. The inactivation of proteolytic enzymes with the capacity to degrade extracellular-matrix proteins may be one of the major clinical effects of tamol in the treatment of acute inflammatory dermatoses.
authors.affiliation: Department of Dermatology, University of Kiel, Germany.
authors.forename: O
authors.initials: O
authors.lastname: Wiedow
authors.forename: F
authors.initials: F
authors.lastname: Weindler
authors.forename: U
authors.initials: U
authors.lastname: Mrowietz
mesh_terms: D053818:Chymases; D005341:Fibrinolysin / Q000037:antagonists & inhibitors*; D006801:Humans; D047348:Hydrolyzable Tannins; D007700:Kinetics; D019272:Leukocyte Elastase / Q000037:antagonists & inhibitors; D008407:Mast Cells / Q000187:drug effects* / Q000201:enzymology*; D012680:Sensitivity and Specificity; D012697:Serine Endopeptidases / Q000187:drug effects* / Q000378:metabolism*; D015842:Serine Proteinase Inhibitors / Q000494:pharmacology*; D012867:Skin / Q000166:cytology / Q000187:drug effects / Q000201:enzymology; D013634:Tannins / Q000494:pharmacology*
chemical_list: D047348:Hydrolyzable Tannins; D015842:Serine Proteinase Inhibitors; D013634:Tannins; C108021:tamol; D012697:Serine Endopeptidases; D019272:Leukocyte Elastase; D053818:Chymases; D005341:Fibrinolysin