title: Origins and functions of the chlamydial inclusion.
abstract: Chlamydiae dissociate themselves from the endocytic pathway shortly after internalization by actively modifying the vacuole to become fusogenic with sphingomyelin-containing exocytic vesicles. Interaction with this secretory pathway appears to provide a pathogenic mechanism that allows chlamydiae to establish themselves in a site that is not destined to fuse with lysosomes.
authors.affiliation: Host-Parasite Interactions Section, National Institute of Allergy and Infections Diseases, NIH, Rocky Mountain Laboratories, Hamilton, MT 59840, USA. tedvhackstadt@nib.gov
authors.forename: T
authors.initials: T
authors.lastname: Hackstadt
authors.forename: E R
authors.initials: ER
authors.lastname: Fischer
authors.forename: M A
authors.initials: MA
authors.lastname: Scidmore
authors.forename: D D
authors.initials: DD
authors.lastname: Rockey
authors.forename: R A
authors.initials: RA
authors.lastname: Heinzen
mesh_terms: D001693:Biological Transport, Active; D002462:Cell Membrane / Q000378:metabolism; D002690:Chlamydia Infections / Q000503:physiopathology*; D002692:Chlamydia trachomatis / Q000254:growth & development / Q000502:physiology* / Q000648:ultrastructure; D004705:Endocytosis; D006801:Humans; D002479:Inclusion Bodies / Q000378:metabolism* / Q000382:microbiology; D008561:Membrane Fusion; D008954:Models, Biological