title: Dietary vitamin E and selenium affect mastitis and milk quality.
abstract: Vitamin E and selenium (SE) are essential nutrients that are integral components of the antioxidant defense of tissues and cells. Soils in many of the important dairy regions of the world are Se-deficient, and feedstuffs grown on these soils will not provide adequate dietary Se. Cattle consuming stored forages are likely to be low in vitamin E unless supplemented, and vitamin E deficiencies are frequently observed in peripartum dairy cows. Many new intramammary infections (IMI) occur in the 2 wk before and after calving. Deficiencies of either vitamin E or Se have been associated with increased incidence and severity of IMI, increased clinical mastitis cases, and higher somatic cell counts (SCC) in individual cows and bulk tank milk. Somatic cell counts are a primary indicator of mastitis and milk quality in dairy herds. The polymorphonuclear neutrophil (PMN) is a major defensive mechanism against infection in the bovine mammary gland. A know consequence of vitamin E and Se deficiency is impaired PMN activity and postpartum vitamin E deficiencies are frequently observed in dairy cows. Dietary supplementation of cows with Se and vitamin E results in a more rapid PMN influx into milk following intramammary bacterial challenge and increased intracellular kill of ingested bacteria by PMN. Subcutaneous injections of vitamin E approximately 10 and 5 d before calving successfully elevated PMN alpha-tocopherol concentrations during the periparturient period and negated the suppressed intracellular kill of bacteria by PMN that commonly is observed around calving.
authors.affiliation: Department of Animal Sciences, Ohio State University, Ohio Agricultural Research and Development Center, Wooster 44691, USA.
authors.forename: K L
authors.initials: KL
authors.lastname: Smith
authors.forename: J S
authors.initials: JS
authors.lastname: Hogan
authors.forename: W P
authors.initials: WP
authors.lastname: Weiss
mesh_terms: D000818:Animals; D002417:Cattle / Q000378:metabolism*; D002418:Cattle Diseases / Q000503:physiopathology; D004032:Diet / Q000592:standards / Q000662:veterinary*; D005260:Female; D015994:Incidence; D007279:Injections, Subcutaneous / Q000662:veterinary; D007774:Lactation; D008414:Mastitis, Bovine / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control*; D008892:Milk / Q000166:cytology / Q000378:metabolism / Q000592:standards*; D009504:Neutrophils / Q000166:cytology / Q000502:physiology; D012643:Selenium / Q000008:administration & dosage / Q000172:deficiency / Q000494:pharmacology*; D014810:Vitamin E / Q000008:administration & dosage / Q000494:pharmacology*; D014811:Vitamin E Deficiency / Q000150:complications / Q000503:physiopathology / Q000662:veterinary
chemical_list: D014810:Vitamin E; D012643:Selenium