Facilitated analysis of data on drug regimen compliance.
Drug actions depend on dose and intervals between doses, in ways that are drug-specific and sometimes complex, complicating the use of drug dosing histories as an explanatory variable in the analysis of clinical trials. We describe a spread-sheet method for conveniently displaying patients' drug dosing histories, to facilitate identification of dosing correlates of clinically important events.
de Klerk
E
E
Department of Internal Medicine, University Hospital Maastricht, The Netherlands.
van der Linden
S
S
van der Heijde
D
D
Urquhart
J
J
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D017326:Clinical Trials, Phase III as Topic; D004282:Documentation / Q000379:methods*; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D016903:Drug Monitoring / Q000379:methods*; D006801:Humans; D015337:Multicenter Studies as Topic; D010349:Patient Compliance; D013167:Spondylitis, Ankylosing / Q000188:drug therapy
D000894:Anti-Inflammatory Agents, Non-Steroidal