Controlled release of cytarabine from poly(2-hydroxyethyl methacrylate-co-N-vinyl-2-pyrrolidone) hydrogels.
Controlled release of cytarabine (ara-C) from poly(2-hydroxyethyl methacrylate-co-N-vinyl-2-pyrrolidone) [p(HEMA-co-VP)] hydrogels cross-linked with ethylene glycol dimethacrylate (EGDMA) is reported. Three compositions of copolymer, each one with a different cross-linking degree, have been studied: H50/VP50, H75/VP25, and H80/VP20. Ara-C (5-25 mg by disc) was trapped in the gels by including it in the polymerization feed mixture. The ara-C release time was between 1 day from H50/VP50/E0.5 discs and 16 days from H80/VP20/E15 discs. In all cases there is a time period for which the drug release rate is constant.
Blanco
M D
MD
Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Univèrsidad Complutense de Madrid, Spain.
Trigo
R M
RM
García
O
O
Teijón
J M
JM
D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage / Q000493:pharmacokinetics*; D001672:Biocompatible Materials / Q000737:chemistry* / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D003432:Cross-Linking Reagents; D003561:Cytarabine / Q000008:administration & dosage / Q000493:pharmacokinetics*; D003692:Delayed-Action Preparations; D005782:Gels; D008689:Methacrylates; D011102:Polyhydroxyethyl Methacrylate / Q000737:chemistry* / Q000378:metabolism; D011108:Polymers; D011760:Pyrrolidinones / Q000737:chemistry* / Q000378:metabolism
D000964:Antimetabolites, Antineoplastic; D001672:Biocompatible Materials; D003432:Cross-Linking Reagents; D003692:Delayed-Action Preparations; D005782:Gels; D008689:Methacrylates; D011108:Polymers; D011760:Pyrrolidinones; D003561:Cytarabine; D011102:Polyhydroxyethyl Methacrylate; C042670:N-vinyl-2-pyrrolidinone; C004919:ethylene dimethacrylate