title: Acute basophilic leukaemia and translocation t(X;6)(p11;q23).
abstract: We report two infants with acute basophilic leukaemia associated with a t(X;6)(p11;q23) as the sole abnormality. Morphologic evidence of basophilic lineage was provided by light and electron microscopy. Both patients also had a similar presentation on diagnosis, characterized by clinical signs consistent with a hyperhistaminaemia syndrome, i.e. urticarian rashes and gastro-intestinal disorders evocative of peptic ulcer. Immunophenotypes differed in the two patients, one expressing CD24, CD13 and CD33, whereas only CD117 was found in the other. Basophilic acute leukaemia, a rare group among acute leukaemias, might be nonrandomly associated with a specific chromosomal abnormality, t(X;6)(p11;q23). This new entity might also be identifiable by an uncommon clinical presentation and occurrence in infancy.
authors.affiliation: Laboratoire d'Hématologie, CHU, Toulouse, France.
authors.forename: N
authors.initials: N
authors.lastname: Dastugue
authors.forename: E
authors.initials: E
authors.lastname: Duchayne
authors.forename: E
authors.initials: E
authors.lastname: Kuhlein
authors.forename: H
authors.initials: H
authors.lastname: Rubie
authors.forename: C
authors.initials: C
authors.lastname: Demur
authors.forename: J
authors.initials: J
authors.lastname: Aurich
authors.forename: A
authors.initials: A
authors.lastname: Robert
authors.forename: P
authors.initials: P
authors.lastname: Sie
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D016026:Bone Marrow Transplantation; D002896:Chromosomes, Human, Pair 6 / Q000235:genetics*; D005260:Female; D006632:Histamine / Q000097:blood; D006801:Humans; D016130:Immunophenotyping; D007223:Infant; D007621:Karyotyping; D015471:Leukemia, Basophilic, Acute / Q000235:genetics* / Q000473:pathology / Q000628:therapy; D008854:Microscopy, Electron; D012074:Remission Induction; D014178:Translocation, Genetic; D014960:X Chromosome / Q000235:genetics*
chemical_list: D006632:Histamine