title: [Secondary prophylaxis in rheumatic fever. Oral antibiotic therapy versus benzathine penicillin].
abstract: OBJECTIVE
  To detect problems related to secondary prophylaxis of rheumatic fever in the setting out patient follow-up.
  
  
  METHODS
  Among 113 pediatric patients admitted with diagnosis of this disease, in a period of five years, we selected 80 records. They were divided in group 1 (60 cases), that only received prescription of benzathine penicillin for prophylaxis and group 2 (20 patients) to whom it was changed from parenteral to oral antibiotics after the detection problems using the first scheme.
  
  
  RESULTS
  In group 1, among 53 who had carditis, 27 (45%) had severe disease; 22 cases (37%) were re-admitted with relapsed carditis following the refusal to use benzathine penicillin. Also, we observed that after discharged 32 (55%) did not return to the out-patient clinic in HUAP. In group 2, from 16 who had carditis, 10 (50%) had severe disease. Only two (10%) did not return to ambulatory control and there was no case of readmission. The difference between the groups was statistically significant. (p < 0.01).
  
  
  CONCLUSIONS
  It was very high the percentage of cases that missed the control visits and abandoned the prophylaxis when it was insisted on parenteral penicillin. We should evaluate every case and remember that oral antibiotics might avoid a major problem.
authors.affiliation: Hospital Universitário Antonio Pedro-UFF, Niterói.
authors.forename: G V
authors.initials: GV
authors.lastname: Herdy
authors.forename: D C
authors.initials: DC
authors.lastname: Souza
authors.forename: P B
authors.initials: PB
authors.lastname: Barros
authors.forename: C A
authors.initials: CA
authors.lastname: Pinto
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D004917:Erythromycin / Q000627:therapeutic use*; D006801:Humans; D010352:Patient Dropouts; D010401:Penicillin G Benzathine / Q000627:therapeutic use*; D010406:Penicillins / Q000627:therapeutic use*; D012213:Rheumatic Fever / Q000188:drug therapy*; D013411:Sulfadiazine / Q000627:therapeutic use*
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D010406:Penicillins; D013411:Sulfadiazine; D004917:Erythromycin; D010401:Penicillin G Benzathine
vernacular_title: Profilaxia secundária na febre reumática. Antibioticoterapia oral versus penicilina benzatina.