Efficacy of amino acid infusion for improving protein metabolism after surgery: a prospective randomized study in patients undergoing subtotal gastrectomy.
BACKGROUND
Appropriate regimens of peripheral parenteral nutrition (PPN) have been proposed for the improvement of protein metabolism after surgery. When evaluating the efficacy of administered nutrients, it is vital to consider the severity of surgical stresses to avoid confounding effects of the trauma on the postoperative metabolism. This study was designed to evaluate protein-sparing regimens through PPN in patients who had undergone subtotal gastrectomy.


METHODS
Patients hospitalized at our institutes for gastric cancer were randomly divided into the following five groups and received PPN for 7 days after surgery: 1. G group (n = 9), 200 g glucose (per day); 2. AG group (n = 10), 54 g amino acids + 150 g glucose; 3. AGG group (n = 9), AG + 110 g glucose; 4. AGF group (n = 10), AG + 40 g fat; and 5. AGL group (n = 7), 58 g amino acids + 60 g glycerol. Biochemical studies were done before and after surgery.


RESULTS
In comparison to G group patients, AG group patients showed less negative cumulative nitrogen balances. No significant differences in cumulative nitrogen balances were observed between AGG, AGF, and AGL groups. Restoration of the reduced serum rapid turnover protein occurred earlier in the AGL group than in either the AGG or the AGF groups. Hyperglycemia, glucosuria, and hyperinsulinemia were prominent in the AGG group, and less prominent in the AGL group. Marked ketosis together with an increase in serum-free fatty acid levels was found in the AGL group.


CONCLUSIONS
These results suggest that in patients who have undergone major elective surgery, infusion of amino acid solutions is advantageous for improving protein metabolism after surgery, and nonprotein energy source and intake are not essential when combined with amino acid solutions for improving nitrogen balance after surgery.
Mimura
Y
Y
Department of Surgery, University of Tokyo, and Showa Hospital, Bunkyo-ku, Japan.
Yamakawa
M
M
Maeda
J
J
Tateno
I
I
Araki
S
S
Fujita
T
T
Sugizaki
K
K
Furuya
K
K
Oohara
T
T
D000328:Adult; D000368:Aged; D000596:Amino Acids / Q000008:administration & dosage*; D017558:Elective Surgical Procedures; D005260:Female; D005743:Gastrectomy; D005947:Glucose / Q000008:administration & dosage; D005990:Glycerol / Q000008:administration & dosage; D006801:Humans; D007263:Infusions, Parenteral; D008297:Male; D008875:Middle Aged; D009584:Nitrogen / Q000378:metabolism; D010288:Parenteral Nutrition; D011182:Postoperative Care; D011446:Prospective Studies; D011506:Proteins / Q000378:metabolism*; D013274:Stomach Neoplasms / Q000601:surgery
D000596:Amino Acids; D011506:Proteins; D005947:Glucose; D009584:Nitrogen; D005990:Glycerol