Effects of sympathectomy on endothelin-1 and histamine responses of rabbit carotid artery.
1. The effects of chronic sympathectomy on contractile responses of rabbit common carotid artery was studied in vitro. 2. Endothelin-1 (ET-1), histamine, KC1 and papaverine concentration-response curves of sympathectomized and sham-operated (control) vessels were recorded and analyzed. Effects of endothelium removal also were investigated. 3. The contractions elicited by ET-1 and histamine in sympathectomized preparations did not change when compared with controls. Papaverine, which produces endothelium-independent relaxation, and KC1, which produces endothelium-independent contraction, did not differ from controls. No significant difference was observed between the contractile responses of sympathectomized vessels and those of control vessels to ET-1 and histamine after the removal of endothelium. 4. These results indicate that chronic sympathectomy did not affect the sensitivity to exogenous ET-1 and histamine of the vascular smooth muscle.
Utkan
T
T
Department of Pharmacology, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey.
Kaya
T
T
Sarioglu
Y
Y
D000818:Animals; D002339:Carotid Arteries / Q000187:drug effects* / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D019332:Endothelin-1 / Q000494:pharmacology*; D005260:Female; D006632:Histamine / Q000494:pharmacology*; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D011817:Rabbits; D013562:Sympathectomy
D019332:Endothelin-1; D006632:Histamine