Successful thrombolysis after prosthetic pulmonary valve obstruction under aspirin monotherapy.
In a 22-year-old woman with recent onset of left-sided chest pain and exertional dyspnea, echocardiography revealed obstruction of a St. Jude Medical bileaflet prosthetic valve (size 23 mm) in the pulmonary position. Oral anticoagulation had been replaced for the previous 7 years by aspirin as the sole antithrombotic treatment. The valve had been inserted 16 years ago for pulmonary atresia. Valve function was restored by systemic application of 9 million units of urokinase.
Burger
W
W
Department of Interventional Cardiology, St. Georg Hospital Leipzig, Germany.
Kneissl
G D
GD
Hartmann
A
A
Bauersachs
R
R
Döring
V
V
Spengler
U
U
Neumann
G
G
Rothe
K W
KW
D000328:Adult; D001241:Aspirin / Q000627:therapeutic use; D005260:Female; D006801:Humans; D010960:Plasminogen Activators / Q000627:therapeutic use; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use; D011475:Prosthesis Failure; D011664:Pulmonary Valve; D011665:Pulmonary Valve Insufficiency / Q000188:drug therapy / Q000209:etiology; D015912:Thrombolytic Therapy; D014568:Urokinase-Type Plasminogen Activator / Q000627:therapeutic use
D010975:Platelet Aggregation Inhibitors; D010960:Plasminogen Activators; D014568:Urokinase-Type Plasminogen Activator; D001241:Aspirin