title: A case-control study of dietary intake and other lifestyle risk factors for hyperplastic polyps.
abstract: OBJECTIVE
  Despite the high prevalence of the hyperplastic polyp, little is known about its etiology. The aim of this study was to assess the relationship between diet and other lifestyle factors and the presence of colorectal hyperplastic polyps.
  
  
  METHODS
  Information on diet and other known or suspected risk factors for colorectal cancer or adenoma was collected among 81 subjects with hyperplastic polyps and 480 controls.
  
  
  RESULTS
  The multivariate-adjusted odds ratio (OR) for hyperplastic polyps for individuals in the upper vs. the lower quartile was 0.30 (95% confidence interval [CI], 0.10-0.88) for dietary fiber, 0.32 (95% CI, 0.11-0.96) for dietary calcium, 0.90 (95% CI, 0.27-2.95) for total fat, and 2.02 (95% CI, 1.05-3.91) for alcohol consumption. Compared with individuals in the lower category, those in the upper category of body mass index had a higher risk for hyperplastic polyps (OR, 4.50; 95% CI, 1.84-10.97). Cigarette smoking was associated with a higher risk (OR, 1.97; 95% CI, 1.02-3.81 for > 20 pack-years vs. never), whereas an inverse association was seen for use of aspirin and other nonsteroidal anti-inflammatory drugs (OR, 0.29; 95% CI, 0.12-0.67 for once per day or more vs. never).
  
  
  CONCLUSIONS
  Hyperplastic polyps share common lifestyle risk factors with colorectal adenomas and carcinomas.
authors.affiliation: Human Nutrition Center, University of Texas-Houston Health Science Center, School of Public Health, USA.
authors.forename: M E
authors.initials: ME
authors.lastname: Martínez
authors.forename: R S
authors.initials: RS
authors.lastname: McPherson
authors.forename: B
authors.initials: B
authors.lastname: Levin
authors.forename: G A
authors.initials: GA
authors.lastname: Glober
mesh_terms: D000236:Adenoma / Q000453:epidemiology / Q000209:etiology / Q000473:pathology; D000368:Aged; D000428:Alcohol Drinking / Q000503:physiopathology; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D001241:Aspirin / Q000494:pharmacology; D015992:Body Mass Index; D002136:Calcium, Dietary / Q000494:pharmacology; D016022:Case-Control Studies; D003106:Colon / Q000473:pathology; D003111:Colonic Polyps / Q000453:epidemiology* / Q000209:etiology / Q000473:pathology; D015179:Colorectal Neoplasms / Q000453:epidemiology / Q000209:etiology / Q000473:pathology; D004041:Dietary Fats / Q000494:pharmacology; D004043:Dietary Fiber / Q000494:pharmacology; D004435:Eating / Q000502:physiology*; D005260:Female; D006801:Humans; D006965:Hyperplasia / Q000453:epidemiology / Q000209:etiology / Q000473:pathology; D008019:Life Style; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D002136:Calcium, Dietary; D004041:Dietary Fats; D004043:Dietary Fiber; D001241:Aspirin