[Improvement of respiratory burst by individual neutrophils from a patient with chronic granulomatous disease, type X91- under treatment by granulocyte colony-stimulating factor for multiple liver abscess].
A 20-year-old male with chronic granulomatous disease (CGD) was admitted with multiple liver abscesses. He had already been diagnosed as CGD, type X91-, when he was 10 years old. He was successfully treated with antibiotics and granulocyte colony-stimulating factor (G-CSF) combined with continuous drainage of abscess. Employing flow cytometry, respiratory burst by individual neutrophils was measured using 2', 7'-dichlorofluorescein. The fluorescence intensity in all individual neutrophils from the patient under G-CSF treatment was higher than the one without G-CSF. G-CSF can be one of effective therapies for infection in some patients with CGD such as X91-.
Ito
Y
Y
First Department of Internal Medicine, Tokyo Medical College.
Kimura
Y
Y
Suzuki
A
A
Kono
M
M
Shoji
N
N
Tsunawaki
S
S
Kuratsuji
T
T
Toyama
K
K
D000328:Adult; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use*; D006105:Granulomatous Disease, Chronic / Q000097:blood* / Q000628:therapy; D006801:Humans; D008100:Liver Abscess / Q000628:therapy*; D008297:Male; D009504:Neutrophils / Q000378:metabolism*; D016897:Respiratory Burst
D016179:Granulocyte Colony-Stimulating Factor