d-Limonene inhibits N-nitrosobis(2-oxopropyl)amine induced hamster pancreatic carcinogenesis.
The effect of d-limonene on pancreatic carcinogenesis induced by N-nitrosobis(2-oxopropyl)amine (BOP) was investigated in Syrian golden hamsters. During and after 5 weekly injections of BOP, each hamster was fed diet containing d-limonene. In week 26, quantitative histological analysis showed that prolonged treatment with d-limonene significantly reduced the number of pancreatic carcinomas. Administration of d-limonene did not cause a significant increase in the apoptotic index, but caused a significant decrease in the BrdU labeling index of carcinoma. These findings indicate that d-limonene inhibits the development of pancreatic carcinoma not by enhancing tumor cell loss through apoptosis, but rather by inhibiting cell proliferation.
Nakaizumi
A
A
Department of Gastrointestinal Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Higashinari-ku, Japan.
Baba
M
M
Uehara
H
H
Iishi
H
H
Tatsuta
M
M
D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D001973:Bromodeoxyuridine / Q000378:metabolism; D002277:Carcinoma / Q000139:chemically induced* / Q000473:pathology; D006224:Cricetinae; D053138:Cyclohexenes; D004261:DNA Replication / Q000187:drug effects; D000077222:Limonene; D008297:Male; D008647:Mesocricetus; D009602:Nitrosamines / Q000494:pharmacology*; D010190:Pancreatic Neoplasms / Q000139:chemically induced* / Q000473:pathology; D013729:Terpenes / Q000494:pharmacology*
D053138:Cyclohexenes; D009602:Nitrosamines; D013729:Terpenes; C013622:nitrosobis(2-oxopropyl)amine; D000077222:Limonene; D001973:Bromodeoxyuridine