title: Repeated administration intensifies the reinforcing effect of fencamfamine in rats.
abstract: 1. In the present study, we evaluated the role of repeated administration on conditioning place preference (CPP) induced by fencamfamine (FCF) in male rats. 2. Repeated FCF (3.5 mg/kg) or saline once or daily for ten consecutive days enhanced sniffing duration and decreased locomotion and rearing duration. 3. At the 3.5 mg/kg dose, FCF produced a significant place-preference effect. 4. Repeated exposures to FCF intensified its reinforcing properties. 5. These results suggest that repeated FCF administration sensitizes its rewarding effects, as with other addictive substances.
authors.affiliation: Departamento de Farmacologia, Unviersidade de São Paulo, Brazil.
authors.forename: R
authors.initials: R
authors.lastname: DeLucia
authors.forename: C S
authors.initials: CS
authors.lastname: Planeta
authors.forename: M L
authors.initials: ML
authors.lastname: Aizenstein
authors.forename: C
authors.initials: C
authors.lastname: Scavone
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D000697:Central Nervous System Stimulants / Q000008:administration & dosage*; D003214:Conditioning, Classical / Q000187:drug effects*; D018491:Dopamine Agonists / Q000008:administration & dosage*; D008297:Male; D009636:Norbornanes / Q000008:administration & dosage*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000697:Central Nervous System Stimulants; D018491:Dopamine Agonists; D009636:Norbornanes; C020900:fencamfamine