Altered platelet magnesium and plasma and urinary soluble form of intercellular adhesion molecule I (sICAM-1) concentrations in insulin dependent diabetes mellitus (IDDM) patients with microalbuminuria.
Magnesium concentrations in plasma, erythrocyte and platelet, and plasma and urine levels of the soluble form of Intercellular Adhesion Molecule-1 (sICAM-1) were evaluated in subjects with insulin dependent diabetes mellitus (IDDM) with or without microalbuminuria, and in a control group of healthy subjects. Using a recently introduced technique, we found that magnesium concentrations in platelets in diabetic subjects with microalbuminuria were lower than in diabetics with normal albuminuria (1.859 +/- 0.47 vs 2.065 +/- 0.62 mumol/10(8) cells; P < 0.05). Moreover, IDDM subjects had higher plasma sICAM-1 levels than control subjects; no difference, however, was found between sICAM-1 concentrations in the two groups of diabetics. An inverse correlation was found between intraplatelet magnesium and plasma sICAM-1 levels (r = - 0.64; P < 0.05) in the diabetics with microalbuminuria. It is concluded that the reduced intraplatelet magnesium content may contribute to the progression of the vascular complications in IDDM subjects with microalbuminuria.
Corica
F
F
Department of Internal Medicine, University of Messina, Italy. coricaf@imeuniv.unime.it
Allegra
A
A
Buemi
M
M
Ientile
R
R
Corsonello
A
A
Di Benedetto
A
A
Bonanzinga
S
S
Ruello
A
A
D'Angelo
R
R
Cucinotta
D
D
Ceruso
D
D
D000293:Adolescent; D000328:Adult; D000419:Albuminuria / Q000097:blood* / Q000652:urine; D001792:Blood Platelets / Q000378:metabolism*; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000652:urine; D005260:Female; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000652:urine*; D008274:Magnesium / Q000097:blood*; D008275:Magnesium Deficiency / Q000175:diagnosis; D008297:Male; D012995:Solubility
D018799:Intercellular Adhesion Molecule-1; D008274:Magnesium