title: MHC class II B genes in the channel catfish (Ictalurus punctatus).
abstract: Two different cDNA sequences for major histocompatibility complex (MHC) class II beta chains from the channel catfish (Ictalurus punctatus) have been identified. Homology between these sequences and those previously identified as MHC class II B genes in other teleosts suggests they represent alleles of the DAB locus. The inferred amino acid sequences show strong evidence for a functional polypeptide chain with a peptide binding region. Southern blot analysis reveals polymorphism in the MHC class II B gene(s) of the channel catfish and suggests the presence of two to four genes.
authors.affiliation: Department of Biology, East Carolina University, Greenville, NC 27858, USA.
authors.forename: U B
authors.initials: UB
authors.lastname: Godwin
authors.forename: A
authors.initials: A
authors.lastname: Antao
authors.forename: M R
authors.initials: MR
authors.lastname: Wilson
authors.forename: V G
authors.initials: VG
authors.lastname: Chinchar
authors.forename: N W
authors.initials: NW
authors.lastname: Miller
authors.forename: L W
authors.initials: LW
authors.lastname: Clem
authors.forename: T J
authors.initials: TJ
authors.lastname: McConnell
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D015139:Blotting, Southern; D005802:Genes, MHC Class II / Q000235:genetics*; D007059:Ictaluridae / Q000235:genetics*; D008969:Molecular Sequence Data; D010802:Phylogeny; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D017386:Sequence Homology, Amino Acid; D012689:Sequence Homology, Nucleic Acid