The effect of intracranial pressure on myelination and the relationship with neurodevelopment in infantile hydrocephalus.
The effect of raised intracranial pressure (ICP), due to infantile hydrocephalus, on the process of myelination has been suggested in the literature. In this study 19 hydrocephalic infants were followed-up with anterior fontanelle pressure (AFP) measurement (assessment of ICP), MRI (assessment of the myelination process and the CSF volume), and neurodevelopmental testing (NDT). There was a high correlation (r = 0.80) between the myelination and NDT scores. The size of the CSF volume showed a poor correlation with the mean AFP, the degree of myelination and the NDT scores. There was, however, a significant correlation between the mean AFP and the degree of myelination (r = 0.67) and also between the mean AFP and the NDT scores (r = 0.70). Longer-term follow-up (mean = 27 months) showed a significant correlation between the early progress of myelination and later developmental level (r = 0.78). Most of the children with a severely delayed myelination, preoperatively, showed a recovery of myelination following CSF drainage. It was concluded that: (1) raised ICP is related to developmental outcome, through the process of myelination; (2) the delay in myelination can be (partially) reversible; and (3) CSF volume is of minor importance regarding neurodevelopment.
Hanlo
P W
PW
Department of Child Neurology, Utrecht University Hospital, The Netherlands.
Gooskens
R J
RJ
van Schooneveld
M
M
Tulleken
C A
CA
van der Knaap
M S
MS
Faber
J A
JA
Willemse
J
J
D001921:Brain / Q000254:growth & development* / Q000473:pathology*; D002658:Developmental Disabilities / Q000209:etiology* / Q000473:pathology; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006849:Hydrocephalus / Q000150:complications*; D007223:Infant; D008279:Magnetic Resonance Imaging; D008297:Male; D009186:Myelin Sheath / Q000473:pathology*; D009483:Neuropsychological Tests; D011237:Predictive Value of Tests; D011379:Prognosis; D011559:Pseudotumor Cerebri / Q000150:complications* / Q000601:surgery