title: Susceptibility to type 1 diabetes in the Senegalese population is linked to HLA-DQ and not TAP and LMP genes.
abstract: OBJECTIVE
  To investigate the frequency of the transporter associated with antigen processing (TAP) and large multifunctional protease (LMP) alleles and their role in the susceptibility to type 1 diabetes, in comparison with the well-known HLA-DQ alleles susceptibility, in Senegalese subjects.
  
  
  METHODS
  Three loci in the TAP/LMP region were analyzed in 92 type 1 diabetic subjects and 117 nondiabetic control subjects by means of polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).
  
  
  RESULTS
  No association was found between the studied polymorphisms of TAP1, TAP2, and LMP2 and type 1 diabetes in the Senegalese population, in contrast to the HLA-DQA1 and DQB1 genes, which were associated with type 1 diabetes.
  
  
  CONCLUSIONS
  Diabetogenic genes in the class II HLA region are located near the DQA1 and DQB1 loci rather than the TAP and LMP loci.
authors.affiliation: Laboratoire de Biochimie, Fondation Hôpital Saint-Jospeh, Paris, France.
authors.forename: M
authors.initials: M
authors.lastname: Chauffert
authors.forename: A
authors.initials: A
authors.lastname: Cissé
authors.forename: D
authors.initials: D
authors.lastname: Chevenne
authors.forename: J F
authors.initials: JF
authors.lastname: You
authors.forename: S
authors.initials: S
authors.lastname: Michel
authors.forename: F
authors.initials: F
authors.lastname: Trivin
mesh_terms: D018528:ATP-Binding Cassette Transporters / Q000235:genetics*; D000293:Adolescent; D000328:Adult; D002648:Child; D004247:DNA / Q000032:analysis; D017931:DNA Primers / Q000737:chemistry; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics* / Q000276:immunology; D010450:Endopeptidases / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005802:Genes, MHC Class II / Q000235:genetics*; D005838:Genotype; D006683:HLA-DQ Antigens / Q000235:genetics* / Q000276:immunology; D006801:Humans; D008285:Major Histocompatibility Complex; D008297:Male; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D012675:Senegal
chemical_list: D018528:ATP-Binding Cassette Transporters; D017931:DNA Primers; D006683:HLA-DQ Antigens; D004247:DNA; D010450:Endopeptidases