title: Treatment of presumed fungal endophthalmitis with oral fluconazole.
abstract: Amphotericin B is the usual treatment for fungal endophthalmitis, but its toxicity and lack of oral bioavailability may limit its use in some patients. The authors report the successful management of two cases of presumed metastatic fungal endophthalmitis with oral fluconazole, a bis-triazole compound with a broad antifungal spectrum.
authors.affiliation: Department of Ophthalmology, New Jersey Medical School, University of Medicine and Dentistry, Newark, USA.
authors.forename: M A
authors.initials: MA
authors.lastname: Zarbin
authors.forename: E
authors.initials: E
authors.lastname: Becker
authors.forename: J
authors.initials: J
authors.lastname: Witcher
authors.forename: A
authors.initials: A
authors.lastname: Yamani
authors.forename: A R
authors.initials: AR
authors.lastname: Irvine
mesh_terms: D000284:Administration, Oral; D000368:Aged; D000935:Antifungal Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D009877:Endophthalmitis / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology; D015821:Eye Infections, Fungal / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology; D015725:Fluconazole / Q000008:administration & dosage* / Q000627:therapeutic use; D005500:Follow-Up Studies; D005654:Fundus Oculi; D006801:Humans; D008297:Male; D014792:Visual Acuity; D014822:Vitreous Body / Q000382:microbiology / Q000473:pathology
chemical_list: D000935:Antifungal Agents; D015725:Fluconazole