title: From stem cells to lymphocytes: biology and transplantation.
abstract: We review the development of the hematopoietic system, focusing on the transition from hematopoietic stem cells (HSCs) to T cells. This includes the isolation of HSCs, and recent progress in understanding their ontogeny, homing properties, and differentiation. HSC transplantation is reviewed, including the kinetics of reconstitution, engraftment across histocompatibility barriers, the facilitation of allogeneic engraftment, and the mechanisms of graft rejection. We describe progress in understanding T-cell development in the bone marrow and thymus as well as the establishment of lymph nodes. Finally, the role of bcl-2 in regulating homeostasis in the hematopoietic system is discussed.
authors.affiliation: Department of Pathology, Stanford University School of Medicine, California 94305, USA.
authors.forename: H L
authors.initials: HL
authors.lastname: Aguila
authors.forename: K
authors.initials: K
authors.lastname: Akashi
authors.forename: J
authors.initials: J
authors.lastname: Domen
authors.forename: K L
authors.initials: KL
authors.lastname: Gandy
authors.forename: E
authors.initials: E
authors.lastname: Lagasse
authors.forename: R E
authors.initials: RE
authors.lastname: Mebius
authors.forename: S J
authors.initials: SJ
authors.lastname: Morrison
authors.forename: J
authors.initials: J
authors.lastname: Shizuru
authors.forename: S
authors.initials: S
authors.lastname: Strober
authors.forename: N
authors.initials: N
authors.lastname: Uchida
authors.forename: D E
authors.initials: DE
authors.lastname: Wright
authors.forename: I L
authors.initials: IL
authors.lastname: Weissman
mesh_terms: D000818:Animals; D018380:Hematopoietic Stem Cell Transplantation / Q000266:history* / Q000379:methods; D006412:Hematopoietic Stem Cells / Q000276:immunology*; D049673:History, 20th Century; D006801:Humans; D014181:Transplantation Immunology