Effects of ischemia-reperfusion injury on myocardial single pass extraction and retention of Cu-PTSM in perfused rat hearts: comparison with 201T1 and 14C-iodoantipyrine.
The effects of ischemia-reperfusion-induced myocardial damage on the single pass extraction and retention of 64Cu-pyruvaldehyde-di(N4-methylthiosemicabazone) (64Cu-PTSM) in perfused rat hearts were compared to these effects on that of 201T1 and 14C-iodoantipyrine. 201T1 and 14C-iodoantipyrine did not show significant changes, but in the case of 64Cu-PTSM, the single pass extraction and retention was reduced with reperfusion. These findings indicate that ischemia-reperfusion-induced myocardial damage decrease the generator-produced 62Cu-labeled 62Cu-PTSM extraction and retention, and that 62Cu-PTSM might have potential not only as a blood flow tracer but also as a functional tracer.
Wada
K
K
Department of Radiopharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Kyoto University, Japan.
Fujibayashi
Y
Y
Taniuchi
H
H
Tajima
N
N
Tamaki
N
N
Konishi
J
J
Yokoyama
A
A
D000818:Animals; D000983:Antipyrine / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D002250:Carbon Radioisotopes; D003301:Copper Radioisotopes; D066298:In Vitro Techniques; D008297:Male; D017202:Myocardial Ischemia / Q000378:metabolism*; D015428:Myocardial Reperfusion Injury / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism*; D009942:Organometallic Compounds / Q000493:pharmacokinetics*; D010477:Perfusion; D011868:Radioisotopes; D051381:Rats; D017208:Rats, Wistar; D013794:Thallium Radioisotopes; D013882:Thiosemicarbazones / Q000493:pharmacokinetics*
D002250:Carbon Radioisotopes; D003301:Copper Radioisotopes; D009942:Organometallic Compounds; D011868:Radioisotopes; D013794:Thallium Radioisotopes; D013882:Thiosemicarbazones; C052629:copper pyruvaldehyde bis(N(4)-methylthiosemicarbazone) complex; D000983:Antipyrine; C008135:iodoantipyrine