[Chemical and biological evaluation of the effect of plant extracts against Plasmodium berghei].
Extracts from thirteen species of plants were evaluated by "in vivo" antimalarial test against plasmodium berghei effects. Significant activities were observed in the ethyl acetate and aqueous extracts, elaborated of Cedrela tonduzii leaves, Trichilia havanensis and Trichilia americana barks, Neurolaena lobata and Gliricidia sepium leaves and Duranta repens fruits. Compounds identified include flavanoids, coumarins, mellilotic acid and iridoids which some kind of biodynamic activity has previously been reported. The flavone quercetin 1 purified from C. tonduzii gave strong antimalarial activity, however, its respective glucosides (quercetin 3-glucoside 2 y robinine 7) showed little significant activity.
Castro
O
O
Universidad Nacional, Departamento de Química, Heredia, Costa Rica.
Barrios
M
M
Chinchilla
M
M
Guerrero
O
O
D000818:Animals; D000962:Antimalarials / Q000494:pharmacology / Q000627:therapeutic use*; D003374:Coumarins / Q000494:pharmacology / Q000627:therapeutic use*; D005419:Flavonoids / Q000494:pharmacology / Q000627:therapeutic use*; D005960:Glucosides / Q000494:pharmacology / Q000627:therapeutic use*; D008288:Malaria / Q000188:drug therapy* / Q000469:parasitology; D051379:Mice; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology*; D010962:Plasmodium berghei / Q000187:drug effects* / Q000469:parasitology
D000962:Antimalarials; D003374:Coumarins; D005419:Flavonoids; D005960:Glucosides; D010936:Plant Extracts
Evaluación química y biológica del efecto de extractos de plantas contra.