[The functional activity of pulmonary surfactant in chronic bronchitis].
Lung surfactant (LS) was examined in the course of chronic bronchitis (CB) development in 25 subjects with CB risk factors (RF), 80 with prebronchitis (PB), 30 with chronic non-obstructive bronchitis (CNOB) and 45 with chronic obstructive bronchitis (COB). Biochemical study of the expirates covered total phospholipids (TP), fractions of neutral lipids, several fatty acids (FA), malonic dialdehyde (MDA), antiradical activity (ARA). Development of CB was accompanied with shifts in LS functional activity. In patients with RF the shifts reflected adaptation. In PB, CNOB and COB patients LS got damaged. The damage was detected by biochemical markers: elevated level of polyunsaturated FA, accumulation of MDA and low ARA.
Gel'tser
B I
BI
Maĭdanov
Iu V
IuV
D001944:Breath Tests / Q000379:methods; D001991:Bronchitis / Q000503:physiopathology*; D002908:Chronic Disease; D006801:Humans; D015227:Lipid Peroxidation; D008055:Lipids / Q000032:analysis; D009784:Occupational Diseases / Q000503:physiopathology*; D011663:Pulmonary Surfactants / Q000502:physiology*
D008055:Lipids; D011663:Pulmonary Surfactants
Funktsional'naia aktivnost' surfaktanta legkikh pri khronicheskom bronkhite.