title: Hyperamylasemia due to macroamylasemia in adult gluten enteropathy.
abstract: We report hyperamylasemia due to macroamylasemia in a 33-year-old-woman with gluten enteropathy. Macroamylasemia was demonstrated by precipitation of 97% of amylase activity with PEG 6000. It was associated with increased serum IgA, with elevated values of specific IgA antibodies against alpha-gliadin and with a high titre of IgA anti-endomysium antibodies. Macroamylasemia disappeared after 2 months of a strict gluten-free diet. These data suggest that the increased IgA concentration in adult gluten enteropathy led to increased macroamylase formation.
authors.affiliation: Department of Clinical Biochemistry, University of Pavia, Policlinico San Matteo, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Bonetti
authors.forename: G
authors.initials: G
authors.lastname: Serricchio
authors.forename: A
authors.initials: A
authors.lastname: Giudici
authors.forename: M
authors.initials: M
authors.lastname: Bettonagli
authors.forename: G B
authors.initials: GB
authors.lastname: Vadacca
authors.forename: R
authors.initials: R
authors.lastname: Bruno
authors.forename: E
authors.initials: E
authors.lastname: Coslovich
authors.forename: R
authors.initials: R
authors.lastname: Moratti
mesh_terms: D000328:Adult; D000681:Amylases / Q000097:blood* / Q000652:urine; D002446:Celiac Disease / Q000097:blood* / Q000201:enzymology* / Q000276:immunology; D005260:Female; D005903:Gliadin / Q000276:immunology; D006801:Humans; D046911:Macromolecular Substances
chemical_list: D046911:Macromolecular Substances; D005903:Gliadin; D000681:Amylases; C001663:macroamylase