Azathioprine-induced multisystem organ failure and cardiogenic shock.
Azathioprine is administered to treat increasing numbers of disorders over a wide range of organ systems. The potential for the drug to cause widespread organ dysfunction is not fully appreciated. In fact, azathioprine can cause multisystem organ dysfunction involving the kidneys, liver, and cardiovascular system. The discovery of global cardiac dysfunction as one component of this complication may indicate a mechanism of hypotension. Clinicians must be aware of the potential for azathioprine to cause such toxicities to facilitate appropriate patient management.
Brown
G
G
Department of Pharmacy, St. Paul's Hospital, Vancouver, British Columbia, Canada.
Boldt
C
C
Webb
J G
JG
Halperin
L
L
D001327:Autoimmune Diseases / Q000188:drug therapy; D001379:Azathioprine / Q000009:adverse effects*; D004342:Drug Hypersensitivity / Q000209:etiology*; D006505:Hepatitis / Q000188:drug therapy; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000139:chemically induced*; D012770:Shock, Cardiogenic / Q000139:chemically induced*
D007166:Immunosuppressive Agents; D001379:Azathioprine