Radical modulation activity of benzo[a]phenothiazine.
12H-Benzo[a]phenothiazine generated radical(s) under alkaline conditions, and enhanced the radical intensity of sodium ascorbate and sodium 5,6-benzylidene-L-ascorbate. Phenothiazine and chlorpromazine hydrochloride did not produce radicals, nor affect the radical intensity of ascorbates. 12H-Benzo[a]phenothiazine scavenged the superoxide anion and hydroxyl radical, more efficiently than phenothiazine and chlorpromazine hydrochloride. The radical modulation activity of 12H-benzo[a]phenothiazine might explain at least in part the ability of this compound to induce monocytic differentiation and apoptosis in human myelogenous leukemic cell lines.
Satoh
K
K
Analysis Center, School of Pharmaceutical Sciences, Showa University, Tokyo, Japan.
Sakagami
H
H
Motohashi
N
N
D000975:Antioxidants / Q000737:chemistry; D001205:Ascorbic Acid / Q000737:chemistry; D002746:Chlorpromazine / Q000737:chemistry; D004578:Electron Spin Resonance Spectroscopy; D005609:Free Radicals; D005707:Gallic Acid / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D017665:Hydroxyl Radical / Q000737:chemistry; D010640:Phenothiazines / Q000737:chemistry*; D012997:Solvents; D013481:Superoxides / Q000737:chemistry
D000975:Antioxidants; D005609:Free Radicals; D010640:Phenothiazines; D012997:Solvents; D013481:Superoxides; C107575:benzophenothiazine; D017665:Hydroxyl Radical; D005707:Gallic Acid; D001205:Ascorbic Acid; D002746:Chlorpromazine