[Cardiac phospholipids in the dynamics of experimental myocardial infarct in rats].
The study was undertaken to examine the cardiac levels and composition of phospholipids (PL) in the time course of rat experimental myocardial infarction (EMI) caused by the Selye procedure. The course of EMI was shown to be accompanied by a rise in the total levels of PH in the cardiomyocytic membranes, which was observed 1 hour and 14 days after the occurrence of EMI. Analyzing the composition of individual PL demonstrated higher concentrations of the minor PL phosphatidylserine and phosphatidylinositol, as well as differently directed changes in the content of massive PL: lower concentrations of phosphatidylethanolamine and higher levels of phosphatidylcholine. The pattern of the found changes altered in relation to the duration of EMI. By and large, the revealed changes reflect the processes of transbilayer redistribution of PL, alterations in their physicochemical properties and in the rate of lipid peroxidation occurring in the membranes.
Torkunov
P A
PA
Sapronov
N S
NS
Novoselova
N Iu
NIu
Nalivaeva
N N
NN
D000818:Animals; D002462:Cell Membrane / Q000737:chemistry / Q000378:metabolism; D008297:Male; D009203:Myocardial Infarction / Q000378:metabolism*; D009206:Myocardium / Q000737:chemistry / Q000378:metabolism*; D009336:Necrosis; D010743:Phospholipids / Q000032:analysis / Q000378:metabolism*; D051381:Rats; D013997:Time Factors
D010743:Phospholipids
Fosfolipidy serdtsa v dinamike éksperimental'nogo infarkta miokarda u krys.