title: Automated chemical synthesis: from resins to instruments.
abstract: Solid-phase organic synthesis is now a prevalent activity in drug discovery. In keeping with this keen interest is the need to develop reliable automated synthesis instrumentation as well as polymeric supports and linkers suitable for the full range of organic synthesis applications. In this paper, we review our activities in the development of new and enabling tools for automated chemical synthesis, including the following: (i) new solid supports such as ArgoGel (PS-PEG-based) and Argo-X203 (PS-based); and (ii) the Nautilus 2400 system, a fully closed and inert automated chemistry development workstation. Selected chemistry optimization and synthesis examples performed on the Nautilus and new solid supports will be described.
authors.affiliation: Argonaut Technologies Inc., San Carlos, CA 94070, USA.
authors.forename: J A
authors.initials: JA
authors.lastname: Porco
authors.forename: T
authors.initials: T
authors.lastname: Deegan
authors.forename: W
authors.initials: W
authors.lastname: Devonport
authors.forename: O W
authors.initials: OW
authors.lastname: Gooding
authors.forename: K
authors.initials: K
authors.lastname: Heisler
authors.forename: J W
authors.initials: JW
authors.lastname: Labadie
authors.forename: B
authors.initials: B
authors.lastname: Newcomb
authors.forename: C
authors.initials: C
authors.lastname: Nguyen
authors.forename: P
authors.initials: P
authors.lastname: van Eikeren
authors.forename: J
authors.initials: J
authors.lastname: Wong
authors.forename: P
authors.initials: P
authors.lastname: Wright
mesh_terms: D001331:Automation; D001671:Biochemistry / Q000295:instrumentation* / Q000379:methods*; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D011092:Polyethylene Glycols / Q000138:chemical synthesis; D011137:Polystyrenes / Q000138:chemical synthesis; D012116:Resins, Plant / Q000138:chemical synthesis*; D013997:Time Factors
chemical_list: D007202:Indicators and Reagents; D011137:Polystyrenes; D012116:Resins, Plant; C103390:polyethylene glycol-polystyrene; D011092:Polyethylene Glycols