title: Cancer incidence rate and mortality rate in sickle cell disease patients at Howard University Hospital: 1986-1995.
abstract: The incidence of cancer in patients with sickle cell disease (SCD) is not known. The 10-year follow-up data on 696 patients with SCD was analyzed at our institution in order to determine the cancer incidence and cancer mortality rates. The age range was 18 to 79 years, with a mean age of 28.8 years. There were 377 females and 319 males. The median follow-up was 3 years. Five patients developed cancer during this period. The cancer incidence rate was 5/2,864 or 1.74 per 1,000 patient years. The 95% CI was 0.64 to 4.32 per 1,000 patient years. There were 68 deaths with 3 being due to cancer. The cancer mortality rate was 3/2,873 or 1.04 cases per 1,000 patient years. Our data represent the first published paper that the authors are aware of, where the cancer incidence and mortality rates have been calculated for any group of patients with SCD.
authors.affiliation: Department of Medicine, Howard University College of Medicine, Washington, DC 20060, USA.
authors.forename: F W
authors.initials: FW
authors.lastname: Dawkins
authors.forename: K S
authors.initials: KS
authors.lastname: Kim
authors.forename: R S
authors.initials: RS
authors.lastname: Squires
authors.forename: R
authors.initials: R
authors.lastname: Chisholm
authors.forename: J A
authors.initials: JA
authors.lastname: Kark
authors.forename: E
authors.initials: E
authors.lastname: Perlin
authors.forename: O
authors.initials: O
authors.lastname: Castro
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000755:Anemia, Sickle Cell / Q000150:complications* / Q000401:mortality*; D004219:District of Columbia / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000453:epidemiology / Q000209:etiology*