title: Effects of d-amphetamine on task performance and social behavior of humans in a residential laboratory.
abstract: Six healthy adult male volunteers lived for 11 days in a residential laboratory. Acute effects of d-amphetamine (0, 5, or 10 mg/70 kg) on performance of tasks, social interaction, and self-reports of drug effects were measured. Each day, participants engaged in a 6.5-hr work period and a 6.5-hr recreation period. Beverages containing d-amphetamine or placebo were consumed daily before the work period and before the recreation period. d-Amphetamine increased response rate without affecting accuracy on some tasks. d-Amphetamine increased the proportion of time spent engaging in verbal interaction during the first but not the second week of study. No changes in self-reported drug effects were observed. Thus, d-amphetamine improved performance in the absence of stimulant-like subjective effects. This differentiation between performance and subjective effects confirms the importance of determining the effects of drugs on a range of behaviors.
authors.affiliation: Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA. asw26@columbia.edu
authors.forename: A S
authors.initials: AS
authors.lastname: Ward
authors.forename: T H
authors.initials: TH
authors.lastname: Kelly
authors.forename: R W
authors.initials: RW
authors.lastname: Foltin
authors.forename: M W
authors.initials: MW
authors.lastname: Fischman
mesh_terms: D000328:Adult; D000697:Central Nervous System Stimulants / Q000009:adverse effects / Q000494:pharmacology*; D003071:Cognition / Q000187:drug effects; D003913:Dextroamphetamine / Q000009:adverse effects / Q000494:pharmacology*; D006801:Humans; D007858:Learning / Q000187:drug effects; D008297:Male; D008568:Memory / Q000187:drug effects; D011597:Psychomotor Performance / Q000187:drug effects*; D012919:Social Behavior; D013998:Time Perception / Q000187:drug effects
chemical_list: D000697:Central Nervous System Stimulants; D003913:Dextroamphetamine