title: Hepatitis C virus RNA present in saliva but absent in breast-milk of the hepatitis C carrier mother.
abstract: In order to examine whether saliva and breast-milk are mediators of the vertical transmission of hepatitis C virus (HCV) from an HCV carrier mother, serum, saliva, and breast-milk samples from 11 HCV carrier mothers were collected at the time of delivery, and at approximately 1- to 3-months intervals for as long as 30 months postpartum. Serum was also sampled from their children. All samples were analysed for the presence of HCV RNA, using the nested polymerase chain reaction method. No HCV RNA was detected in any breast-milk samples. In saliva, HCV RNA was detected in four of the 11 mothers (36%). These four mothers also had liver function abnormalities. Hepatitis C virus RNA was not detected in any serum samples of the children, and all children had normal liver function. The children were monitored for periods from 2 to 44 months. During this period, there was no evidence of virus transmission. Breast-milk is not likely to be a source of mother-to-child transmission of HCV. Maternal saliva may harbour HCV, but it may not result in infant infection.
authors.affiliation: First Department of Pathology, Kurume University School of Medicine, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Kage
authors.forename: S
authors.initials: S
authors.lastname: Ogasawara
authors.forename: K
authors.initials: K
authors.lastname: Kosai
authors.forename: E
authors.initials: E
authors.lastname: Nakashima
authors.forename: K
authors.initials: K
authors.lastname: Shimamatsu
authors.forename: M
authors.initials: M
authors.lastname: Kojiro
authors.forename: A
authors.initials: A
authors.lastname: Kimura
authors.forename: T
authors.initials: T
authors.lastname: Fujisawa
authors.forename: Y
authors.initials: Y
authors.lastname: Matsukuma
authors.forename: Y
authors.initials: Y
authors.lastname: Ito
authors.forename: S
authors.initials: S
authors.lastname: Kondo
authors.forename: K
authors.initials: K
authors.lastname: Kawano
authors.forename: M
authors.initials: M
authors.lastname: Sata
mesh_terms: D002675:Child, Preschool; D005260:Female; D016174:Hepacivirus / Q000235:genetics / Q000302:isolation & purification*; D006508:Hepatitis Antibodies / Q000032:analysis; D006526:Hepatitis C / Q000635:transmission*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical; D008895:Milk, Human / Q000821:virology*; D016133:Polymerase Chain Reaction; D011247:Pregnancy; D012367:RNA, Viral / Q000032:analysis*; D012463:Saliva / Q000821:virology*; D013997:Time Factors
chemical_list: D006508:Hepatitis Antibodies; D012367:RNA, Viral