title: Libraries from libraries: generation and comparison of screening profiles.
abstract: A positional scanning tetrapeptide library was chemically modified through alkylation and/or reduction of the amide bonds, thus generating three new combinatorial libraries with physico-chemical properties very different from the parent peptide library ('libraries from libraries'). Specific results were obtained with each of these libraries upon screening in kappa-opioid receptor binding and microdilution antimicrobial assays, illustrating the potential of the 'libraries from libraries' concept for the efficient generation of a variety of chemically diverse combinatorial libraries.
authors.affiliation: Torrey Pines Institute for Molecular Studies, San Diego, CA 92121, USA.
authors.forename: R A
authors.initials: RA
authors.lastname: Houghten
authors.forename: S E
authors.initials: SE
authors.lastname: Blondelle
authors.forename: C T
authors.initials: CT
authors.lastname: Dooley
authors.forename: B
authors.initials: B
authors.lastname: Dörner
authors.forename: J
authors.initials: J
authors.lastname: Eichler
authors.forename: J M
authors.initials: JM
authors.lastname: Ostresh
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D004352:Drug Resistance, Microbial; D006168:Guinea Pigs; D009842:Oligopeptides / Q000737:chemistry* / Q000494:pharmacology; D019151:Peptide Library; D017473:Receptors, Opioid, kappa / Q000187:drug effects; D018000:Receptors, Peptide / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D009842:Oligopeptides; D019151:Peptide Library; D017473:Receptors, Opioid, kappa; D018000:Receptors, Peptide