1,3-Dimethylisoguanine, a new purine from the marine sponge Amphimedon viridis.
A new purine, 1,3-dimethylisoguanine (1), has been isolated from the marine sponge Amphimedon viridis and identified by analysis of spectroscopic data. Compound 1 increased the contractions obtained by transmural electrical stimulation in the guinea pig longitudinal muscle/myenteric plexus in a dose-dependent manner.
Chehade
C C
CC
Instituto de Química de São Carlos, Universidade de São Paulo, Brazil.
Dias
R L
RL
Berlinck
R G
RG
Ferreira
A G
AG
Costa
L V
LV
Rangel
M
M
Malpezzi
E L
EL
de Freitas
J C
JC
Hajdu
E
E
D000818:Animals; D004558:Electric Stimulation; D006147:Guanine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006168:Guinea Pigs; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects / Q000502:physiology; D011161:Porifera / Q000737:chemistry*
C107720:1,3-dimethylisoguanine; D006147:Guanine