title: Hyperbaric oxygen therapy in the treatment of Fournier's disease in 11 male patients.
abstract: OBJECTIVE
  Optimal tissue oxygenation, as obtained by hyperbaric oxygen therapy, potentiates or restores the host's bactericidal mechanisms and wound healing activity in patients afflicted by serious synergeic aerobic and anaerobic infections of the cutaneous and subcutaneous tissues. Furthermore, hyperbaric oxygen therapy has a direct toxic effect on anaerobic bacteria. We describe our experience with hyperbaric oxygen therapy in the treatment of 11 patients with Fournier's syndrome.
  
  
  METHODS
  The average age of our patients was 59.5 years; the most common predisponsing condition was diabetes. All patients were treated with antibiotic therapy and hyperbaric oxygen therapy (minimum 5 and maximum 24 cycles, consisting of 90 minutes 2.5 atmosphere absolute pressure). Furthermore, 6 of these patients underwent surgical débridement of the wounds and 3 patients underwent delayed reconstructive surgery.
  
  
  RESULTS
  The results we obtained with hyperbaric oxygen therapy as an adjunctive measure for the treatment of these infections were excellent; our mortality rate for Fournier's disease was 0. Moreover, no complications whatsoever were observed. Furthermore, the 3 patients who underwent delayed corrective surgery presented with well healed tissues and their operations were not complicated by infections or other pathological conditions.
  
  
  CONCLUSIONS
  We believe that our findings, although limited in number, underline the excellent results that can be obtained with hyperbaric oxygen therapy as an adjunct treatment in Fournier's disease.
authors.affiliation: Department of Urology, University of Genoa, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Pizzorno
authors.forename: F
authors.initials: F
authors.lastname: Bonini
authors.forename: A
authors.initials: A
authors.lastname: Donelli
authors.forename: R
authors.initials: R
authors.lastname: Stubinski
authors.forename: M
authors.initials: M
authors.lastname: Medica
authors.forename: G
authors.initials: G
authors.lastname: Carmignani
mesh_terms: D018934:Fournier Gangrene / Q000628:therapy*; D006801:Humans; D006931:Hyperbaric Oxygenation; D008297:Male; D008875:Middle Aged