The prohost effect of antimicrobial agents as a predictor of clinical outcome.
Apart from their direct antimicrobial activity, some antimicrobial agents may interfere in the complex host-microorganism interplay by modulating the natural response to invading pathogens. The three main aspects of this non-antibiotic effect (alteration of bacterial virulence, synergism with/impairment of the natural host response, impact on effector cell progenitors) will be briefly reviewed here, along with their potential incidence in the clinical outcome of infectious diseases.
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INSERM U294, Service d'Hématologie et d'Immunologie Biologiques, CHU Xavier BICHAT, Paris, France.
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects / Q000472:pathogenicity; D006801:Humans; D007107:Immune System / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D011237:Predictive Value of Tests; D016896:Treatment Outcome
D000900:Anti-Bacterial Agents