title: A randomized controlled trial of penicillin vs clindamycin for the treatment of aspiration pneumonia in children.
abstract: OBJECTIVE
  To compare the effectiveness of intravenous penicillin vs clindamycin for the treatment of aspiration pneumonia.
  
  
  METHODS
  A double-blind, randomized controlled trial.
  
  
  METHODS
  A tertiary care pediatric hospital.
  
  
  METHODS
  We enrolled 42 children, aged 6 months to 18 years, who were admitted to the hospital for the treatment of aspiration pneumonia. All of the children had underlying conditions that predispose to aspiration.
  
  
  METHODS
  The patients were randomly assigned to receive intravenous penicillin G sodium, 250,000 U/kg every 24 hours, or intravenous clindamycin phosphate, 30 mg/kg every 24 hours.
  
  
  METHODS
  The primary outcome measure was "time to ready for discharge" from the hospital.
  
  
  RESULTS
  In an effectiveness (intention to treat) analysis, the median time (interquartile range) to ready for discharge from the hospital was 4.9 days (range, 2.8-6.5 days) in the penicillin-treated group and 3.4 days (range, 2.3-6.8 days) in the clindamycin-treated group (P = .66). Results were not markedly altered when adjusted for the age difference of the groups or in the efficacy analysis (after the exclusion of 9 patients who withdrew from the trial). Rates for readmission to the hospital were similar in the 2 groups.
  
  
  CONCLUSIONS
  Penicillin and clindamycin seem to be equally effective for the treatment of aspiration pneumonia in children hospitalized for this illness.
authors.affiliation: Department of Pediatrics, Hospital for Sick Children, Toronto, Ontario.
authors.forename: S J
authors.initials: SJ
authors.lastname: Jacobson
authors.forename: K
authors.initials: K
authors.lastname: Griffiths
authors.forename: S
authors.initials: S
authors.lastname: Diamond
authors.forename: P
authors.initials: P
authors.lastname: Winders
authors.forename: M
authors.initials: M
authors.lastname: Sgro
authors.forename: W
authors.initials: W
authors.lastname: Feldman
authors.forename: C
authors.initials: C
authors.lastname: Macarthur
mesh_terms: D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D002981:Clindamycin / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D010400:Penicillin G / Q000627:therapeutic use*; D010406:Penicillins / Q000627:therapeutic use*; D011015:Pneumonia, Aspiration / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D010406:Penicillins; D002981:Clindamycin; D010400:Penicillin G