title: Altered platelet magnesium and plasma and urinary soluble form of intercellular adhesion molecule I (sICAM-1) concentrations in insulin dependent diabetes mellitus (IDDM) patients with microalbuminuria.
abstract: Magnesium concentrations in plasma, erythrocyte and platelet, and plasma and urine levels of the soluble form of Intercellular Adhesion Molecule-1 (sICAM-1) were evaluated in subjects with insulin dependent diabetes mellitus (IDDM) with or without microalbuminuria, and in a control group of healthy subjects. Using a recently introduced technique, we found that magnesium concentrations in platelets in diabetic subjects with microalbuminuria were lower than in diabetics with normal albuminuria (1.859 +/- 0.47 vs 2.065 +/- 0.62 mumol/10(8) cells; P < 0.05). Moreover, IDDM subjects had higher plasma sICAM-1 levels than control subjects; no difference, however, was found between sICAM-1 concentrations in the two groups of diabetics. An inverse correlation was found between intraplatelet magnesium and plasma sICAM-1 levels (r = - 0.64; P < 0.05) in the diabetics with microalbuminuria. It is concluded that the reduced intraplatelet magnesium content may contribute to the progression of the vascular complications in IDDM subjects with microalbuminuria.
authors.affiliation: Department of Internal Medicine, University of Messina, Italy. coricaf@imeuniv.unime.it
authors.forename: F
authors.initials: F
authors.lastname: Corica
authors.forename: A
authors.initials: A
authors.lastname: Allegra
authors.forename: M
authors.initials: M
authors.lastname: Buemi
authors.forename: R
authors.initials: R
authors.lastname: Ientile
authors.forename: A
authors.initials: A
authors.lastname: Corsonello
authors.forename: A
authors.initials: A
authors.lastname: Di Benedetto
authors.forename: S
authors.initials: S
authors.lastname: Bonanzinga
authors.forename: A
authors.initials: A
authors.lastname: Ruello
authors.forename: R
authors.initials: R
authors.lastname: D'Angelo
authors.forename: D
authors.initials: D
authors.lastname: Cucinotta
authors.forename: D
authors.initials: D
authors.lastname: Ceruso
mesh_terms: D000293:Adolescent; D000328:Adult; D000419:Albuminuria / Q000097:blood* / Q000652:urine; D001792:Blood Platelets / Q000378:metabolism*; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000652:urine; D005260:Female; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000652:urine*; D008274:Magnesium / Q000097:blood*; D008275:Magnesium Deficiency / Q000175:diagnosis; D008297:Male; D012995:Solubility
chemical_list: D018799:Intercellular Adhesion Molecule-1; D008274:Magnesium