title: Bioactive saponins and glycosides. X. On the constituents of zizyphi spinosi semen, the seeds of Zizyphus jujuba Mill. var. spinosa Hu (1): structures and histamine release-inhibitory effect of jujubosides A1 and C and acetyljujuboside B.
abstract: New dammarane-type triterpene oligoglycosides, jujubosides A1 and C and acetyljujuboside B1 were isolated from Zizyphi Spinosi Semen, the seeds of Zizyphus jujuba MILL. var. spinosa Hu, together-with three known saponins. The structures of jujubosides A1 and C and acetyljujuboside B were determined on the basis of chemical and physicochemical evidence. Jujubosides A1 and C and acetyljujuboside B were found to inhibit the histamine release from rat peritoneal exudate cells induced by antigen-antibody-reaction.
authors.affiliation: Kyoto Pharmaceutical University, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Yoshikawa
authors.forename: T
authors.initials: T
authors.lastname: Murakami
authors.forename: A
authors.initials: A
authors.lastname: Ikebata
authors.forename: S
authors.initials: S
authors.lastname: Wakao
authors.forename: N
authors.initials: N
authors.lastname: Murakami
authors.forename: H
authors.initials: H
authors.lastname: Matsuda
authors.forename: J
authors.initials: J
authors.lastname: Yamahara
mesh_terms: D000818:Animals; D001202:Ascitic Fluid / Q000166:cytology; D002240:Carbohydrate Sequence; D006027:Glycosides / Q000138:chemical synthesis* / Q000302:isolation & purification / Q000494:pharmacology*; D006633:Histamine Antagonists / Q000737:chemistry* / Q000494:pharmacology*; D006636:Histamine Release / Q000187:drug effects; D008297:Male; D008968:Molecular Conformation; D008969:Molecular Sequence Data; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D012503:Saponins / Q000737:chemistry* / Q000494:pharmacology*; D012639:Seeds / Q000737:chemistry; D013329:Structure-Activity Relationship
chemical_list: D006027:Glycosides; D006633:Histamine Antagonists; D010936:Plant Extracts; D012503:Saponins