title: Equine viral arteritis in newborn foals: clinical, pathological, serological, microbiological and immunohistochemical observations.
abstract: Clinical, pathological, immunohistochemical, serological and microbiological findings are described for 2 geographically and temporally distinct equine arteritis virus (EAV) epidemics in newborn foals. Outbreak A occurred at a commercial Standardbred breeding facility; Outbreak B began in a group of research animals. Clinical signs were severe and primarily referable to the respiratory tract. Fever and leucopenia and/or thrombocytopenia were observed in foals surviving for more than 24 h. The most common gross pathological findings were limited to the respiratory tract. Common histopathological findings included interstitial pneumonia, lymphocytic arteritis and periarteritis with fibrinoid necrosis of the tunica media. Renal tubular necrosis was noted in 2 foals. Immunoperoxidase histochemistry combined with virus isolation was diagnostic in all cases.
authors.affiliation: Department of Pathology, Cornell University, College of Veterinary Medicine, Ithaca, New York 14853, USA.
authors.forename: F
authors.initials: F
authors.lastname: Del Piero
authors.forename: P A
authors.initials: PA
authors.lastname: Wilkins
authors.forename: J W
authors.initials: JW
authors.lastname: Lopez
authors.forename: A L
authors.initials: AL
authors.lastname: Glaser
authors.forename: E J
authors.initials: EJ
authors.lastname: Dubovi
authors.forename: D H
authors.initials: DH
authors.lastname: Schlafer
authors.forename: D H
authors.initials: DH
authors.lastname: Lein
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D018174:Arterivirus Infections / Q000150:complications / Q000453:epidemiology / Q000473:pathology / Q000662:veterinary*; D004196:Disease Outbreaks / Q000662:veterinary*; D007240:Equartevirus / Q000302:isolation & purification*; D005260:Female; D005334:Fever / Q000662:veterinary; D006734:Horse Diseases / Q000097:blood / Q000473:pathology* / Q000821:virology; D006736:Horses; D007150:Immunohistochemistry; D007684:Kidney Tubules / Q000473:pathology / Q000821:virology; D007970:Leukopenia / Q000662:veterinary; D008168:Lung / Q000098:blood supply / Q000473:pathology / Q000821:virology; D017563:Lung Diseases, Interstitial / Q000662:veterinary; D008297:Male; D009336:Necrosis; D009395:Nephritis, Interstitial / Q000662:veterinary; D013921:Thrombocytopenia / Q000662:veterinary