Antiemetic effects of morphine on motion- and drug-induced emesis in Suncus murinus.
Emetic and antiemetic effects of morphine were investigated in Suncus murinus. Subcutaneous (up to 30 mg/kg) or intracerebroventricular administration (50 micrograms) of morphine failed to cause emesis. However, pretreatment with morphine (s.c.) prevented the emesis induced by nicotine (10 mg/kg, i.p.), copper sulfate (40 mg/kg, p.o.), cisplatin (20 mg/kg, i.p.) and motion stimulus. These results suggest that morphine has only antiemetic potency and may block a common mechanism for the emetic reflex of suncus, because the antiemetic effects of the drug were exerted irrespective of the stimulus.
Kakimoto
S
S
Department of Chemical Pharmacology, Faculty of Pharmaceutical Science, University of Tokyo, Japan.
Saito
H
H
Matsuki
N
N
D000818:Animals; D000932:Antiemetics / Q000627:therapeutic use*; D002945:Cisplatin / Q000009:adverse effects; D019327:Copper Sulfate / Q000009:adverse effects; D005260:Female; D007276:Injections, Intraventricular; D007279:Injections, Subcutaneous; D008297:Male; D009020:Morphine / Q000627:therapeutic use*; D009041:Motion Sickness / Q000517:prevention & control*; D009538:Nicotine / Q000009:adverse effects; D012788:Shrews; D014839:Vomiting / Q000139:chemically induced / Q000209:etiology / Q000517:prevention & control*
D000932:Antiemetics; D009538:Nicotine; D009020:Morphine; D019327:Copper Sulfate; D002945:Cisplatin