title: The structural and functional basis of antibody catalysis.
abstract: Ten years have passed since the initial reports that antibodies could be programmed to have enzymatic activity by immunization with a transition-site analog. Much of the research over the last decade has focused on defining the scope and generality of antibody catalysis; however, during the past two years the first few crystal structures of catalytic antibody transition-state analogs have been reported. This review analyzes four such structures of catalytic antibodies that catalyze markedly different reactions, including ester hydrolysis, sulfide oxidation, and a pericyclic rearrangement. Structure-function relations for these catalysts are discussed and compared to the structure and function of natural enzymes, as well as the chemistry that occurs in solution.
authors.affiliation: Department of Pharmaceutical Chemistry, University of California, San Francisco 94143, USA.
authors.forename: H
authors.initials: H
authors.lastname: Wade
authors.forename: T S
authors.initials: TS
authors.lastname: Scanlan
mesh_terms: D017151:Antibodies, Catalytic / Q000737:chemistry* / Q000378:metabolism*; D000937:Antigen-Antibody Reactions; D008958:Models, Molecular; D013329:Structure-Activity Relationship
chemical_list: D017151:Antibodies, Catalytic