The concentration of u-PA and PAI-1 antigen in tissue extracts of nasopharyngeal carcinoma.
We measured the antigen levels of urokinase-type plasminogen activator (u-PA) and plasminogen activator inhibitor-1 (PAI-1) in tissue extracts from nasopharyngeal carcinomas. An increase in u-PA antigen was observed with the advanced stages of disease. However, the levels of PAI-1 antigen decreased with each advanced stage. These results suggest that local administration of antiplasminic agents may be effective in suppressing tumor invasion.
Sunagawa
M
M
1st Department of Physiology, School of Medicine, University of the Ryukyus, Okinawa, Japan.
Huang
G W
GW
Nakamura
M
M
Kosugi
T
T
D000328:Adult; D000368:Aged; D000951:Antigens, Neoplasm / Q000032:analysis*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000737:chemistry* / Q000276:immunology*; D009361:Neoplasm Invasiveness; D010960:Plasminogen Activators / Q000276:immunology*; D015849:Plasminogen Inactivators / Q000276:immunology*; D014568:Urokinase-Type Plasminogen Activator / Q000276:immunology*
D000951:Antigens, Neoplasm; D015849:Plasminogen Inactivators; D010960:Plasminogen Activators; D014568:Urokinase-Type Plasminogen Activator