title: [Polymicrobial endocarditis: a clinical and evolutive study of 12 cases diagnosed during a 10-year period].
abstract: Polymicrobial endocarditis (PE) is uncommon, whether in series of cases of polymicrobial bacteriemia or of endocarditis. Among the 201 cases of infective endocarditis seen between 1986 and 1995 by an infectious diseases service, 12 patients had PE (6%). Nine were males, mean age was 28 years and ten were active intravenous drug users. All of them were HIV (+) and 50% had AIDS. Eleven subjects had infection of the tricuspid valve and 58% developed septic pulmonary emboli. The most common organism encountered was Staphylococcus aureus in 8 patients followed by Streptococcus viridans and S. pneumoniae in three. The most common combinations of organisms were S. aureus and S. pneumoniae in 3 cases and S. aureus and Pseudomonas aeruginosa in two. Two patients died, one with Xantomona maltophilia and another with Candida albicans. The symptoms of PE were usually indistinguishable from endocarditis caused by a single organism and the prognosis depended on the species rather than the number of organisms isolated.
authors.affiliation: Servicio de Enfermedades Infecciosas, Centro de Investigación Clínica, Instituto de Salud Carlos III, Madrid.
authors.forename: M E
authors.initials: ME
authors.lastname: Valencia Ortega
authors.forename: A
authors.initials: A
authors.lastname: Enríquez Crego
authors.forename: J
authors.initials: J
authors.lastname: Guinea Esquerdo
authors.forename: J
authors.initials: J
authors.lastname: González Lahoz
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy; D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002176:Candida albicans / Q000302:isolation & purification; D004697:Endocarditis, Bacterial / Q000188:drug therapy / Q000209:etiology / Q000382:microbiology*; D005260:Female; D006801:Humans; D008297:Male; D011550:Pseudomonas aeruginosa / Q000302:isolation & purification; D013211:Staphylococcus aureus / Q000302:isolation & purification; D013291:Streptococcus / Q000302:isolation & purification; D013296:Streptococcus pneumoniae / Q000302:isolation & purification; D015819:Substance Abuse, Intravenous / Q000150:complications
chemical_list: D000900:Anti-Bacterial Agents
vernacular_title: Endocarditis polimicrobiana: estudio clínico y evolutivo de doce casos diagnosticados durante un período de diez años.