Fatty acid acylation of platelet proteins.
A variety of fatty acids can become covalently attached to platelet proteins by thioester linkage. These fatty acids include palmitate, myristate, stearate, arachidonate, and eicosapentaenoate. More than 20 platelet proteins can be acylated by fatty acids. Several of the acylated platelet proteins have been identified, including glycoprotein Ib beta, glycoprotein IX, P-selectin, G-protein alpha subunits, and CD9. This report reviews the fatty acid acylation of platelet proteins.
Van Cott
E M
EM
Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114-2696, USA.
Muszbek
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L
Laposata
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M
D000215:Acylation; D015703:Antigens, CD / Q000378:metabolism; D001792:Blood Platelets / Q000737:chemistry*; D001798:Blood Proteins / Q000378:metabolism*; D005227:Fatty Acids / Q000378:metabolism*; D019204:GTP-Binding Proteins / Q000378:metabolism; D006801:Humans; D008562:Membrane Glycoproteins; D019007:P-Selectin / Q000378:metabolism; D019038:Platelet Glycoprotein GPIb-IX Complex / Q000378:metabolism; D060245:Tetraspanin 29
D015703:Antigens, CD; D001798:Blood Proteins; C554869:CD9 protein, human; D005227:Fatty Acids; D008562:Membrane Glycoproteins; D019007:P-Selectin; D019038:Platelet Glycoprotein GPIb-IX Complex; D060245:Tetraspanin 29; D019204:GTP-Binding Proteins