title: The role of Helicobacter pylori in the pathophysiology of duodenal ulcer disease and gastric cancer.
abstract: Helicobacter pylori infection is now recognized to be an important acquired factor in the pathogenesis of duodenal ulcer disease. There is also an association between H pylori and the subsequent development of gastric cancer. The mechanism of the association between the infection and those disorders is incompletely understood but there is increasing evidence that H pylori-induced disturbances of gastric function play a pivotal role. In this article we review the role of H pylori infection in the pathophysiology of these important upper gastrointestinal diseases.
authors.affiliation: University Department of Medicine and Therapeutics, Western Infirmary, Glasgow, Scotland.
authors.forename: K E
authors.initials: KE
authors.lastname: McColl
authors.forename: E
authors.initials: E
authors.lastname: el-Omar
authors.forename: D
authors.initials: D
authors.lastname: Gillen
authors.forename: S
authors.initials: S
authors.lastname: Banerjee
mesh_terms: D001205:Ascorbic Acid / Q000378:metabolism; D004381:Duodenal Ulcer / Q000382:microbiology / Q000503:physiopathology*; D005744:Gastric Acid / Q000378:metabolism; D005755:Gastrins / Q000502:physiology; D016481:Helicobacter Infections / Q000382:microbiology / Q000503:physiopathology*; D016480:Helicobacter pylori / Q000472:pathogenicity*; D006801:Humans; D013274:Stomach Neoplasms / Q000382:microbiology / Q000503:physiopathology*
chemical_list: D005755:Gastrins; D001205:Ascorbic Acid