title: [Evaluation of efficacy and safety of etofibrate in primary hyperlipidemia. A multicenter study].
abstract: OBJECTIVE
  To evaluate the clinical efficacy of etofibrate in primary hyperlipidemia in patients from clinical centers representative of all main Brazilian cities.
  
  
  METHODS
  One thousand, nine hundred and fourty three hyperlipidemic patients were submitted to diet and drug treatment with etofibrate (500 mg/day) for eight weeks. The data b WAS analyzed as to changes in the lipoprotein profile, as well as the side effects.
  
  
  RESULTS
  There was an important reduction in total cholesterol (19.88%), triglycerides (29.59%), LDL-c (14.89%) and VLDL-c (14.54%) concentration. There was a significant increase in HDL-c (18.14%). Adverse effects were observed in 8.5% of the patients, without major clinical relevance, however, in 1.44% the treatment had to be interrupted.
  
  
  CONCLUSIONS
  Administration of etofibrate promoted positive changes in all parameters of the lipid and lipoprotein profile, thus reducing the risk of atherosclerotic disease, without significant side effects in the great majority of sample studied.
authors.affiliation: Faculdade de Medicina de Ribeirão Preto-USP.
authors.forename: J E
authors.initials: JE
authors.lastname: dos Santos
authors.forename: A A
authors.initials: AA
authors.lastname: Loures-Vale
authors.forename: J P
authors.initials: JP
authors.lastname: Novazzi
authors.forename: L M
authors.initials: LM
authors.lastname: Rabelo
authors.forename: T L
authors.initials: TL
authors.lastname: Martinez
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002784:Cholesterol / Q000097:blood; D002995:Clofibric Acid / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood / Q000178:diet therapy / Q000188:drug therapy*; D000960:Hypolipidemic Agents / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D014280:Triglycerides / Q000097:blood
chemical_list: D000960:Hypolipidemic Agents; D014280:Triglycerides; C009746:etofibrate; D002995:Clofibric Acid; D002784:Cholesterol
vernacular_title: Avaliação da eficácia e segurança do etofibrato em pacientes dislipidêmicos. Estudo multicêntrico.