The first recurring chromosome translocation in hepatoblastoma: der(4)t(1;4)(q12;q34).
We report four cases of hepatoblastoma with a derivative chromosome 4 from an unbalanced translocation between the long arms of chromosomes 1 and 4, an aberration reported only rarely in isolated cases of other types of neoplasms. The abnormality in three hepatoblastomas was der(4)t(1;4)(q12;q34), whereas the fourth case appeared to have a der(4)t(q25;q32). All had hyperdiploid tumor karyotypes; however, in the case with t(q25;q32), the der(4) was the only abnormality in the stemline. We speculate that the oncogenetic event in our cases may be the loss of a gene on distal 4q or their alteration by juxtaposition to 1q12 heterochromatin.
Schneider
N R
NR
Department of Pathology, UT Southwestern Medical Center, Dallas, TX 75235-9072, USA.
Cooley
L D
LD
Finegold
M J
MJ
Douglass
E C
EC
Tomlinson
G E
GE
D002871:Chromosome Banding; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics*; D002894:Chromosomes, Human, Pair 4 / Q000235:genetics*; D017353:Gene Deletion; D018197:Hepatoblastoma / Q000235:genetics* / Q000473:pathology; D006801:Humans; D007223:Infant; D007621:Karyotyping; D008113:Liver Neoplasms / Q000235:genetics* / Q000473:pathology; D008297:Male; D014178:Translocation, Genetic / Q000235:genetics*