title: NO synthase-II is transiently expressed in embryonic mouse olfactory receptor neurons.
abstract: Among three NO synthase (NOS) isoforms only the inducible NOS-II was localized in developing olfactory receptor neurons of the mouse. First NOS-II immunoreactive receptor cells including their processes were detected by embryonic day 11 when the olfactory pit starts to invaginate. Cellular staining lasted until embryonic day 16, and was reduced during the next few days. At embryonic day 20 no reactivity was found in the olfactory epithelium, whereas centripetal nerve fibers remained positive. This transient expression of NOS-II implies a role for the differentiation of early olfactory receptor neurons and synaptic plasticity.
authors.affiliation: Department of Anatomy, Universität zu Köln, Germany. Stefan.Arnhold@uni-koeln.de
authors.forename: S
authors.initials: S
authors.lastname: Arnhold
authors.forename: C
authors.initials: C
authors.lastname: Andressen
authors.forename: W
authors.initials: W
authors.lastname: Bloch
authors.forename: J K
authors.initials: JK
authors.lastname: Mai
authors.forename: K
authors.initials: K
authors.lastname: Addicks
mesh_terms: D000818:Animals; D002452:Cell Count; D004847:Epithelial Cells; D004848:Epithelium / Q000378:metabolism; D007527:Isoenzymes / Q000096:biosynthesis / Q000378:metabolism*; D051379:Mice; D019001:Nitric Oxide Synthase / Q000096:biosynthesis / Q000378:metabolism*; D009833:Olfactory Pathways / Q000166:cytology / Q000196:embryology* / Q000201:enzymology; D018034:Olfactory Receptor Neurons / Q000737:chemistry* / Q000201:enzymology*; D013997:Time Factors
chemical_list: D007527:Isoenzymes; D019001:Nitric Oxide Synthase