Molecular mechanisms of blood vessel formation.
The formation of new blood vessels, angiogenesis, is a tightly regulated process. Extracellular angiogenic inducers stimulate the migration and proliferation of endothelial cells, while negative regulators counteract this effect. Changes in the relative balance of inducers and inhibitors activate the 'angiogenic switch', before stabilizer molecules activate the maturation of nascent blood vessels.
Bussolino
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F
Departimento di Genetica, Biologia e Chimica Medica, University of Torino, Italy. bussol@molinette.unito.it
Mantovani
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A
Persico
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G
D043168:Angiostatins; D016228:Endothelial Growth Factors / Q000737:chemistry / Q000502:physiology; D004730:Endothelium, Vascular / Q000737:chemistry / Q000502:physiology; D008222:Lymphokines / Q000737:chemistry / Q000502:physiology; D018919:Neovascularization, Physiologic / Q000502:physiology; D010446:Peptide Fragments; D010958:Plasminogen; D021382:Protein Sorting Signals; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors
D016228:Endothelial Growth Factors; D008222:Lymphokines; D010446:Peptide Fragments; D021382:Protein Sorting Signals; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors; D043168:Angiostatins; D010958:Plasminogen