Differential proliferation of endothelial cells and keratinocytes in psoriasis and spongiotic dermatitis.
This study used MIB-1 monoclonal antibody to quantify the proliferating keratinocytes and endothelial cells and their proliferation fractions in cases of normal skin, acute and established plaque psoriasis, and acute and chronic spongiotic dermatitis. The number and the proliferation fraction of MIB-1 positive cells were higher in psoriatic and chronic spongiotic lesions than in normal skin (p < 0.05). Established plaque psoriasis had a higher number of proliferating keratinocytes and a higher keratinocytic proliferation fraction than did acute psoriasis (p < 0.05). The number of proliferating endothelial cells decreased as acute psoriatic lesion became chronic, but the number in acute spongiotic lesion increased as it became chronic. The endothelial proliferation fraction was higher in acute psoriasis than in established plaque psoriasis (p < 0.05). The ratio of keratinocytic proliferation fraction to endothelial cell proliferation fraction of the psoriatic and spongiotic lesions suggested the presence of different reaction patterns to inflammation in psoriasis and spongiotic dermatitis.
Sweet
W L
WL
Department of Dermatology, Stanford University, California, USA.
Smoller
B R
BR
D000293:Adolescent; D000328:Adult; D000368:Aged; D034961:Antigens, Nuclear; D015415:Biomarkers / Q000032:analysis; D001706:Biopsy; D002455:Cell Division; D003877:Dermatitis, Contact / Q000378:metabolism / Q000473:pathology*; D004727:Endothelium / Q000473:pathology*; D005260:Female; D006801:Humans; D015603:Keratinocytes / Q000473:pathology*; D019394:Ki-67 Antigen; D008297:Male; D008875:Middle Aged; D009687:Nuclear Proteins / Q000378:metabolism; D011565:Psoriasis / Q000378:metabolism / Q000473:pathology*
D034961:Antigens, Nuclear; D015415:Biomarkers; D019394:Ki-67 Antigen; D009687:Nuclear Proteins