Protective effects of a novel quinone derivative, E3330, on mouse hepatitis virus (MHV)-induced chronic hepatitis in athymic nude mice.
In this experiment, we examined the protective effects of a novel quinone derivative, E3330, on MHV-2cc-induced chronic hepatitis in athymic nude mice for up to 3 weeks after virus infection. The daily dose of 25 mg/kg b.w. suppressed the viral replication in the liver and the progression of hepatic lesions. The expansion of small focal lesions at 1 week after viral inoculation (WAI) was suppressed at 2 WAI, and the lesions were still small at 3 WAI in E3330-administered group, whereas small focal lesions at 1 WAI were expanded at 2 WAI to fuse with each other at 3 WAI in the control group. E3330 therefore showed protective effects on MHV-2cc-induced chronic hepatitis in athymic nude mice, but further studies are needed to analyze the mechanism.
Uetsuka
K
K
Department of Veterinary Pathology, Faculty of Agriculture, University of Tokyo, Japan.
Suzuki
M
M
Kai
C
C
Goto
N
N
D000284:Administration, Oral; D000818:Animals; D016227:Benzoquinones / Q000494:pharmacology*; D002908:Chronic Disease; D018352:Coronavirus Infections / Q000473:pathology / Q000517:prevention & control*; D005260:Female; D006524:Hepatitis, Viral, Animal / Q000473:pathology / Q000517:prevention & control*; D007370:Interferon Type I / Q000494:pharmacology; D007371:Interferon-gamma / Q000494:pharmacology; D008099:Liver / Q000187:drug effects / Q000473:pathology / Q000821:virology; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D006517:Murine hepatitis virus / Q000302:isolation & purification; D011422:Propionates / Q000494:pharmacology*; D011994:Recombinant Proteins; D014779:Virus Replication / Q000187:drug effects
D016227:Benzoquinones; D007370:Interferon Type I; D011422:Propionates; D011994:Recombinant Proteins; C075569:E 3330; D007371:Interferon-gamma