[Effect of noninvasive ventilation on pulmonary artery pressure in patients with severe kyphoscoliosis].
BACKGROUND
Many studies have shown, that non invasive ventilation via nasal access can normalize alveolar ventilation for individuals due to kyphoscoliotic deformity. The purpose of this study was to evaluate the effect of nasal IPPV on the pulmonary artery pressures (Pam) and the sleep efficiency of kyphoscoliotic individuals.


METHODS
Five patients were studied (4 men, 1 woman; age 50.5 +/- 6.9 years): all patients showed hypoxemia and hypercapnia before therapy. We followed the patients about 6 months under NIPPV. We measured PImax, PaO2, PaCO2, Pam before and after 6 months with NIPPV.


RESULTS
PImax increased from 4.9 +/- 2.3 kPa to 6.5 +/- 1.3 kPa, PaO2 increased from 46.2 +/- 12.2 mmHg to 56.7 +/- 8.5 mmHg. PaCO2 decreased from 53.0 +/- 3.2 to 45.3 +/- 3.2. Pam decreased from 41.0 +/- 15.1 to 23.2 +/- 10.7 in 6 months of NIPPV. Total sleep time increased from 222 +/- 52 min to 326 +/- 43 min with NIPPV.


CONCLUSIONS
Similar to O2 long-term therapy in patients with COPD. NIPPV delivers in patients with kyphoscoliotic deformity a significant reduction of pulmonary artery pressure and increase of sleep quality.
Schlenker
E
E
Klinik Ambrock, Hagen.
Feldmeyer
F
F
Hoster
M
M
Rühle
K H
KH
D000328:Adult; D000368:Aged; D002245:Carbon Dioxide / Q000097:blood; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007384:Intermittent Positive-Pressure Breathing; D007738:Kyphosis / Q000503:physiopathology / Q000628:therapy*; D008173:Lung Diseases, Obstructive / Q000503:physiopathology / Q000628:therapy*; D008176:Lung Volume Measurements; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D011669:Pulmonary Wedge Pressure / Q000502:physiology*
D002245:Carbon Dioxide; D010100:Oxygen
Der Effekt der nichtinvasiven Beatmung auf den pulmonalarteriellen Druck bei Patienten mit schwerer Kyphoskoliose.