title: Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors.
abstract: TRAIL (also called Apo2L) belongs to the tumor necrosis factor family, activates rapid apoptosis in tumor cells, and binds to the death-signaling receptor DR4. Two additional TRAIL receptors were identified. The receptor designated death receptor 5 (DR5) contained a cytoplasmic death domain and induced apoptosis much like DR4. The receptor designated decoy receptor 1 (DcR1) displayed properties of a glycophospholipid-anchored cell surface protein. DcR1 acted as a decoy receptor that inhibited TRAIL signaling. Thus, a cell surface mechanism exists for the regulation of cellular responsiveness to pro-apoptotic stimuli.
authors.affiliation: Department of Molecular Oncology, Genentech, South San Francisco, CA 94080-4918, USA.
authors.forename: J P
authors.initials: JP
authors.lastname: Sheridan
authors.forename: S A
authors.initials: SA
authors.lastname: Marsters
authors.forename: R M
authors.initials: RM
authors.lastname: Pitti
authors.forename: A
authors.initials: A
authors.lastname: Gurney
authors.forename: M
authors.initials: M
authors.lastname: Skubatch
authors.forename: D
authors.initials: D
authors.lastname: Baldwin
authors.forename: L
authors.initials: L
authors.lastname: Ramakrishnan
authors.forename: C L
authors.initials: CL
authors.lastname: Gray
authors.forename: K
authors.initials: K
authors.lastname: Baker
authors.forename: W I
authors.initials: WI
authors.lastname: Wood
authors.forename: A D
authors.initials: AD
authors.lastname: Goddard
authors.forename: P
authors.initials: P
authors.lastname: Godowski
authors.forename: A
authors.initials: A
authors.lastname: Ashkenazi
mesh_terms: D000595:Amino Acid Sequence; D017209:Apoptosis; D051017:Apoptosis Regulatory Proteins; D002462:Cell Membrane / Q000378:metabolism; D002478:Cells, Cultured; D058851:GPI-Linked Proteins; D017261:Glycosylphosphatidylinositols / Q000378:metabolism; D006367:HeLa Cells; D006801:Humans; D008024:Ligands; D008562:Membrane Glycoproteins / Q000378:metabolism*; D008969:Molecular Sequence Data; D016328:NF-kappa B / Q000378:metabolism; D053220:Receptors, TNF-Related Apoptosis-Inducing Ligand; D018124:Receptors, Tumor Necrosis Factor / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D053320:Receptors, Tumor Necrosis Factor, Member 10c; D015398:Signal Transduction; D053221:TNF-Related Apoptosis-Inducing Ligand; D014162:Transfection; D014407:Tumor Cells, Cultured; D053319:Tumor Necrosis Factor Decoy Receptors; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
chemical_list: D051017:Apoptosis Regulatory Proteins; D058851:GPI-Linked Proteins; D017261:Glycosylphosphatidylinositols; D008024:Ligands; D008562:Membrane Glycoproteins; D016328:NF-kappa B; D053220:Receptors, TNF-Related Apoptosis-Inducing Ligand; D018124:Receptors, Tumor Necrosis Factor; D053320:Receptors, Tumor Necrosis Factor, Member 10c; D053221:TNF-Related Apoptosis-Inducing Ligand; C105190:TNFRSF10A protein, human; C505639:TNFRSF10B protein, human; C108661:TNFRSF10C protein, human; C505653:TNFSF10 protein, human; D053319:Tumor Necrosis Factor Decoy Receptors; D014409:Tumor Necrosis Factor-alpha