title: A rare case of gastric cancer in an acromegalic patient.
abstract: Although it has been demonstrated that acromegalic patients have an increased risk of neoplasms, especially colon neoplasms, gastric cancer with acromegaly is very rare--only five cases have been reported to date in Japan. We report here a rare case of gastric cancer with acromegaly in a 58-year-old woman, whose acromegalic change began at age 44. This patient showed typical clinical features of acromegaly, with increased concentrations of blood growth hormone (GH) and insulin-like growth factor I (IGF-I); she had four types of neoplasms; gastric cancer, colon tubular adenoma with moderate atypia, pancreatic mucinous cystadenoma, and subcutaneous lipoma. The gastric cancer was macroscopically 0-IIc type, 3.0 x 2.5 cm in size, and histologically diagnosed as a poorly differentiated adenocarcinoma with limited invasion of the mucosal layer. The previously documented stimulatory effects of GH and/or IGF-I on tumorigenesis and cell proliferation may have been responsible for the development of the multiple neoplasms in our patient.
authors.affiliation: Third Department of Surgery, University of Tokyo, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Asai
authors.forename: S
authors.initials: S
authors.lastname: Shimoyama
authors.forename: N
authors.initials: N
authors.lastname: Sanno
authors.forename: M
authors.initials: M
authors.lastname: Kaminishi
authors.forename: T
authors.initials: T
authors.lastname: Oohara
mesh_terms: D000172:Acromegaly / Q000150:complications* / Q000000981:diagnostic imaging; D000230:Adenocarcinoma / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D000236:Adenoma / Q000150:complications; D001706:Biopsy; D003537:Cystadenoma / Q000150:complications / Q000473:pathology; D003560:Cysts / Q000150:complications / Q000473:pathology; D005260:Female; D006801:Humans; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000150:complications; D010182:Pancreatic Diseases / Q000150:complications / Q000473:pathology; D010911:Pituitary Neoplasms / Q000150:complications; D011859:Radiography; D013274:Stomach Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000473:pathology