[Tribulations of the p16/MTS1/CDKN2 tumor gene suppressor: a continuing saga].
Since its recent discovery on chromosome 9p21 band, the p16INK4a/MTS1/CDKN2 gene has been reported as one of the most frequently impaired tumor suppressor genes (ranking second after p53) in a variety of malignancies, including acute lymphoblastic leukemias. In fact, the situation is likely to be more complex than expected: the gene has a very unusual status in that sense that it encodes two structurally unrelated but functionally similar proteins, p16INK4a and p19ARF. In this minireview, the present status of the gene is examined.
Larsen
C J
CJ
INSERM U. 301, Institut de génétique moléculairer, Paris, France.
D000818:Animals; D002352:Carrier Proteins / Q000235:genetics*; D002453:Cell Cycle / Q000235:genetics; D002899:Chromosomes, Human, Pair 9 / Q000235:genetics; D018899:CpG Islands / Q000235:genetics; D019941:Cyclin-Dependent Kinase Inhibitor p16; D018844:Cyclin-Dependent Kinases / Q000037:antagonists & inhibitors / Q000235:genetics; D019175:DNA Methylation; D004791:Enzyme Inhibitors; D005091:Exons / Q000235:genetics; D016193:G1 Phase; D017353:Gene Deletion; D015972:Gene Expression Regulation, Neoplastic; D016147:Genes, Tumor Suppressor / Q000235:genetics*; D006168:Guinea Pigs; D006801:Humans; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics*; D011401:Promoter Regions, Genetic
D002352:Carrier Proteins; D019941:Cyclin-Dependent Kinase Inhibitor p16; D004791:Enzyme Inhibitors; D018844:Cyclin-Dependent Kinases
Les tribulations du gène suppresseur de tumeur p16/MTS1/CDKN2: un feuilleton à rebondissements.