title: [Effect of controlled hypotension on cerebral oxygen delivery].
abstract: The margin of safety for controlled hypotension is still unclear especially in the central nervous system (CNS) which is one of the most sensitive organs to hypoxia and ischemia. Recently, cerebral optical spectroscopy in the infrared light range was developed as a useful tool which makes it possible to monitor cerebral oxygenation (rSO2) non-invasively and continuously during anesthesia. Resulting rSO2 mainly reflects oxygen extracts by cerebral tissue and then indicates cerebral oxygen delivery. We examined the limitation of controlled hypotension in the brain in 12 patients by monitoring rSO2 during anesthesia. rSO2 under room air breathing (control value as normal physiological condition) was 67 +/- 3% (mean +/- SEM). It significantly increased by 5.6 +/- 0.8% under 100% oxygen breathing, but decreased near to the control value under sevoflurane anesthesia (FIO2 1.0). During moderate controlled hypotension (70% of normal blood pressure) by prostaglandin E1 under sevoflurane anesthesia (FIO2 1.0). rSO2 remained at control value, indicating that cerebral oxygen delivery was still sufficiently maintained. However rSO2 decreased significantly by 9.0 +/- 1.1% in same controlled hypotension condition under FIO2 0.4. This decrease in rSO2 could be potentially harmful for CNS although any post-operative neurological disorder was not observed in our cases. We conclude that cerebral oxygen delivery may be insufficient even in the moderate controlled hypotension, and thus higher FIO2 is recommended in such procedures.
authors.affiliation: Department of Anesthesia, and Emergency and Critical Care Medicine, National Hospital Tokyo Disaster Medical Center, Tachikawa.
authors.forename: M
authors.initials: M
authors.lastname: Tsuchiya
authors.forename: H
authors.initials: H
authors.lastname: Tokai
authors.forename: Y
authors.initials: Y
authors.lastname: Imazu
authors.forename: K
authors.initials: K
authors.lastname: Arai
authors.forename: M
authors.initials: M
authors.lastname: Manabe
mesh_terms: D000527:Alprostadil; D001921:Brain / Q000378:metabolism*; D005260:Female; D006801:Humans; D007023:Hypotension, Controlled / Q000009:adverse effects*; D008875:Middle Aged; D016343:Monitoring, Intraoperative; D010101:Oxygen Consumption; D010102:Oxygen Inhalation Therapy
chemical_list: D000527:Alprostadil