title: Immunological reconstitution following bone marrow transplantation.
abstract: The recipients of hematopoietic stem cell transplants are characterized by an immunodeficiency of varying severity and duration. Their immunoincompetence is due in part to: 1) a lack of sustained transfer of donor immunity, 2) a recapitulation of lymphoid ontogeny, 3) the effects of graft-versus-host disease and its therapy, and 4) a reduction in thymic function. Recipients can have delays in the production of naive T lymphocytes following transplantation which result in defects in the production of new antigen-specific T lymphocytes and an inability to produce antibodies, especially to carbohydrate antigens.
authors.affiliation: Division of Research Immunology/Bone Marrow Transplantation, Children's Hospital, Los Angeles, CA 90027, USA. rparkman%smtpgate@chlais.usc.edu
authors.forename: R
authors.initials: R
authors.lastname: Parkman
authors.forename: K I
authors.initials: KI
authors.lastname: Weinberg
mesh_terms: D000818:Animals; D016026:Bone Marrow Transplantation / Q000009:adverse effects / Q000276:immunology*; D002454:Cell Differentiation / Q000276:immunology; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects; D006801:Humans; D007121:Immunocompetence