title: Defective antigen-induced lymphocyte proliferation in the X-linked hyper-IgM syndrome.
abstract: We examined T-cell proliferation in five patients with X-linked hyper-IgM syndrome (XHIM), using a panel of antigens and lectins. All patients had impaired antigen-induced proliferation, whereas their lectin responses were normal. Thus, in addition to severely depressed antibody responses, patients with XHIM have a defect in antigen-specific T-cell proliferation, which may explain their susceptibility to pathogens such as Pneumocystis carinii.
authors.affiliation: Department of Molecular Medicine, University of Auckland, New Zealand.
authors.forename: R
authors.initials: R
authors.lastname: Ameratunga
authors.forename: H M
authors.initials: HM
authors.lastname: Lederman
authors.forename: K E
authors.initials: KE
authors.lastname: Sullivan
authors.forename: H D
authors.initials: HD
authors.lastname: Ochs
authors.forename: K
authors.initials: K
authors.lastname: Seyama
authors.forename: J K
authors.initials: JK
authors.lastname: French
authors.forename: R
authors.initials: R
authors.lastname: Prestidge
authors.forename: J
authors.initials: J
authors.lastname: Marbrook
authors.forename: W C
authors.initials: WC
authors.lastname: Fanslow
authors.forename: J A
authors.initials: JA
authors.lastname: Winkelstein
mesh_terms: D000941:Antigens / Q000276:immunology*; D000946:Antigens, Fungal; D019013:CD40 Antigens / Q000235:genetics; D002175:Candida / Q000276:immunology; D003208:Concanavalin A; D003457:Cryptosporidiosis / Q000276:immunology; D004168:Diphtheria Toxoid; D004198:Disease Susceptibility / Q000276:immunology; D008040:Genetic Linkage; D006801:Humans; D006942:Hypergammaglobulinemia / Q000235:genetics / Q000276:immunology*; D007075:Immunoglobulin M; D007153:Immunologic Deficiency Syndromes / Q000235:genetics / Q000276:immunology*; D037102:Lectins; D008024:Ligands; D008213:Lymphocyte Activation / Q000276:immunology*; D008297:Male; D010835:Phytohemagglutinins; D011020:Pneumonia, Pneumocystis / Q000276:immunology; D011043:Pokeweed Mitogens; D013601:T-Lymphocytes / Q000276:immunology*; D013745:Tetanus Toxoid; D014960:X Chromosome
chemical_list: D000941:Antigens; D000946:Antigens, Fungal; D019013:CD40 Antigens; D004168:Diphtheria Toxoid; D007075:Immunoglobulin M; D037102:Lectins; D008024:Ligands; D010835:Phytohemagglutinins; D011043:Pokeweed Mitogens; D013745:Tetanus Toxoid; D003208:Concanavalin A