title: Randomised placebo controlled trial of mefenamic acid for premedication at outpatient hysteroscopy: a pilot study.
abstract: An increasing number of diagnostic hysteroscopies are being performed in an outpatient setting. Most women tolerate the examination well, but the single commonest reason for failure is pain. We assessed the efficacy of a nonsteroidal, anti-inflammatory analgesic as premedication before hysteroscopy in a double-blind, placebo controlled trial. Our results showed that 500 mg mefenamic acid given one hour before hysteroscopy had no significant benefit in the discomfort experienced during the procedure but did significantly reduce pain after hysteroscopy. A larger dose or a longer interval between premedication and hysteroscopy may possibly be associated with greater benefits.
authors.affiliation: Minimally Invasive Therapy Unit, University Department of Obstetrics and Gynaecology, Royal Free Hospital, London, UK.
authors.forename: F
authors.initials: F
authors.lastname: Nagele
authors.forename: G
authors.initials: G
authors.lastname: Lockwood
authors.forename: A L
authors.initials: AL
authors.lastname: Magos
mesh_terms: D000328:Adult; D000368:Aged; D000553:Ambulatory Care; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D015907:Hysteroscopy / Q000379:methods*; D007247:Infertility, Female / Q000209:etiology; D008528:Mefenamic Acid / Q000627:therapeutic use*; D008875:Middle Aged; D010146:Pain / Q000517:prevention & control*; D010147:Pain Measurement; D010865:Pilot Projects; D011292:Premedication; D014592:Uterine Hemorrhage / Q000209:etiology
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D008528:Mefenamic Acid