Cisplatin-induced nephrotoxicity and the protective effect of fosfomycin on it as demonstrated by using a crossover study of urinary metabolite levels.
BACKGROUND
Cisplatin induces nephrotoxicity and this study evaluated the protective effect of fosfomycin on it in 11 gynecological cancer patients.


METHODS
The N-acetyl-beta-D-glucosaminidase (NAG), beta 2-microglobulin (beta 2MG), creatinine (uCr) and total protein (TP) levels in a 24-hour urine specimen as well as the blood urea nitrogen (BUN) and serum creatinine (sCr) were measured before and after CAPF chemotherapy alone (control) or with fosfomycin.


RESULTS
The results were statistically analyzed by using the t-test. NAG, beta 2MG, uCr and TP levels increased significantly after chemotherapy in the control patients, but BUN and sCr levels did not change significantly. The NAG level in the control group was twice as high as in the fosfomycin group 8 days after chemotherapy (p < 0.01). The uCr and TP in control patients increased significantly after chemotherapy when compared to those in patients coad-ministered fosfomycin. There were no significant changes in beta 2MG, BUN and sCr levels.


CONCLUSIONS
Cisplatin affected the levels of NAG, beta 2MG, uCr and TP without influencing BUN and sCr levels. Fosfomycin, therefore, may be useful as a supplemental treatment for reducing cisplatin nephrotoxicity, especially proximal tubular damage.
Hayashi
M
M
Department of Obstetrics and Gynecology, Koshigaya Hospital, Dokkyo University School of Medicine, Saitama, Japan.
Numaguchi
M
M
Watabe
H
H
Enomoto
H
H
Yaoi
Y
Y
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use / Q000652:urine; D002945:Cisplatin / Q000627:therapeutic use* / Q000633:toxicity / Q000652:urine; D018592:Cross-Over Studies; D005260:Female; D005578:Fosfomycin / Q000627:therapeutic use* / Q000652:urine; D005833:Genital Neoplasms, Female / Q000188:drug therapy* / Q000652:urine; D005839:Gentamicins / Q000627:therapeutic use / Q000652:urine; D006801:Humans; D007668:Kidney / Q000187:drug effects; D007683:Kidney Tubular Necrosis, Acute / Q000139:chemically induced* / Q000652:urine
D005839:Gentamicins; D005578:Fosfomycin; D002945:Cisplatin