title: Seizure after overdose of tramadol.
abstract: Tramadol (Ultram) is a new analgesic agent with a dual mechanism of action that includes weak agonistic effects at the mu-opioid receptor as well as inhibition of neurotransmitter (serotonin, norepinephrine) re-uptake. Although it has proven to be a safe and effective agent for the control of pain, adverse effects can occur with its use. I report the occurrence of seizure activity after the inadvertent administration of 4 mg/kg of tramadol to a child. Previous reports of seizure activity after tramadol administration are reviewed and the treatment of this problem is discussed.
authors.affiliation: Department of Child Health, University of Missouri, Columbia 65212, USA.
authors.forename: J D
authors.initials: JD
authors.lastname: Tobias
mesh_terms: D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000009:adverse effects*; D062787:Drug Overdose / Q000150:complications; D005260:Female; D006801:Humans; D007223:Infant; D007275:Injections, Intravenous; D012640:Seizures / Q000139:chemically induced*; D014147:Tramadol / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D000701:Analgesics, Opioid; D014147:Tramadol