Auditory event-related potentials and statistical probability mapping in obsessive-compulsive disorder.
The current exploratory investigation was undertaken to replicate and extend previous findings of auditory event related potentials (ERPs) observed in obsessive-compulsive disorder (OCD). Similar to previous ERP studies, this study revealed a decreased slow wave (SW) (post P300) latency, a trend towards decreased P300 latency and a greater N200 amplitude in OCD subjects than in controls. In addition, the chronicity of OCD symptoms was correlated with the 140-170 millisecond integrated amplitude and the severity of OCD symptoms correlated with the 386-438 millisecond integrated amplitude. Current findings lend additional support to evidence suggesting OCD represents, in part, hyperarousal of the cortex.
de Groot
C M
CM
Department of Psychiatric Medicine, East Carolina University, Greenville, North Carolina 27858-4354, USA.
Torello
M W
MW
Boutros
N N
NN
Allen
R
R
D000328:Adult; D001143:Arousal / Q000502:physiology; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000503:physiopathology; D004292:Dominance, Cerebral / Q000502:physiology; D004569:Electroencephalography / Q000706:statistics & numerical data*; D018913:Event-Related Potentials, P300 / Q000502:physiology; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009771:Obsessive-Compulsive Disorder / Q000175:diagnosis / Q000503:physiopathology*; D011336:Probability; D011930:Reaction Time / Q000502:physiology; D012016:Reference Values