title: Allelic association of juvenile absence epilepsy with a GluR5 kainate receptor gene (GRIK1) polymorphism.
abstract: Juvenile absence epilepsy (JAE) is a common subtype of idiopathic generalized epilepsy (IGE). Hereditary factors play a major role in its etiology. The important function of glutamate receptors (GluRs) in excitatory neurotransmission, synaptic plasticity, and neurodevelopment suggests their involvement in epileptogenesis. A tetranucleotide repeat polymorphism in the non-coding region of the kainate-selective GluR5 receptor gene (GRIK1) on chromosome 21q22.1 provides the tool to investigate this candidate gene. The present association and linkage study tested the hypothesis that allelic variants of GRIK1 confer genetic susceptibility to the pathogenesis of JAE. Our family-based association analysis using the haplotype-based haplotype relative risk statistic revealed an association of JAE with the nine-repeat containing allele of the GRIK1 tetranucleotide polymorphism (chi2 = 8.31, df = 1, P = 0.004). Supportive evidence for linkage to a JAE related IGE spectrum (Zmax = 1.67 at GRIK1) under an autosomal dominant mode of inheritance and significant allele sharing (P < 0.05) among the affected family members suggest that allelic variants of GRIK1 contribute a major genetic determinant to the pathogenesis of JAE-related phenotypes.
authors.affiliation: Department of Neurology, University Hospital Rudolf Virchow, Berlin, Germany.
authors.forename: T
authors.initials: T
authors.lastname: Sander
authors.forename: T
authors.initials: T
authors.lastname: Hildmann
authors.forename: R
authors.initials: R
authors.lastname: Kretz
authors.forename: R
authors.initials: R
authors.lastname: Fürst
authors.forename: U
authors.initials: U
authors.lastname: Sailer
authors.forename: G
authors.initials: G
authors.lastname: Bauer
authors.forename: B
authors.initials: B
authors.lastname: Schmitz
authors.forename: G
authors.initials: G
authors.lastname: Beck-Mannagetta
authors.forename: T F
authors.initials: TF
authors.lastname: Wienker
authors.forename: D
authors.initials: D
authors.lastname: Janz
mesh_terms: D000483:Alleles; D001317:Austria / Q000453:epidemiology; D002891:Chromosomes, Human, Pair 21 / Q000235:genetics*; D004252:DNA Mutational Analysis; D004198:Disease Susceptibility; D004832:Epilepsy, Absence / Q000145:classification / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D005838:Genotype; D005858:Germany / Q000453:epidemiology; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D008126:Lod Score; D008297:Male; D018895:Microsatellite Repeats; D010375:Pedigree; D011110:Polymorphism, Genetic; D018092:Kainic Acid Receptors / Q000235:genetics*; D012306:Risk
chemical_list: D018092:Kainic Acid Receptors