title: [Anti-Mycobacterium avium complex activities of KRM-1648, clarithromycin and levofloxacin in 7HSF medium at peak or average blood concentrations after their oral administration of clinical dosages].
abstract: We evaluated the anti-Mycobacterium avium complex (MAC) activities of KRM-1648 (KRM), clarithromycin (CAM) and levofloxacin (LVFX) in 7HSF medium at concentrations in human blood after their oral administration of clinical dosages. MAC organisms were inoculated into tubes containing the medium with or without the addition of test drugs at either 1/10 Cmax, Cmax or C0-8h (average concentrations during the first 8 h) in the blood. KRM at Cmax or C0-8h showed strong bactericidal activity against MAC, CAM showed weak or moderate degree of bactericidal activity at Cmax and C0-8h, while LVFX added at Cmax or C0-8h showed only a weak bacteriostatic effect against M. avium, but did not show any effect against M. intracellulare.
authors.affiliation: Department of Microbiology and Immunology, Shimane Medical University, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Sato
authors.forename: T
authors.initials: T
authors.lastname: Akaki
authors.forename: H
authors.initials: H
authors.lastname: Tomioka
mesh_terms: D000284:Administration, Oral; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000097:blood; D000890:Anti-Infective Agents / Q000008:administration & dosage* / Q000097:blood; D000904:Antibiotics, Antitubercular / Q000008:administration & dosage* / Q000097:blood; D017291:Clarithromycin / Q000008:administration & dosage* / Q000097:blood; D003470:Culture Media; D006801:Humans; D064704:Levofloxacin; D015269:Mycobacterium avium Complex / Q000187:drug effects*; D015242:Ofloxacin / Q000008:administration & dosage* / Q000097:blood; D012294:Rifamycins / Q000008:administration & dosage* / Q000097:blood
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000904:Antibiotics, Antitubercular; D003470:Culture Media; D012294:Rifamycins; C068980:KRM 1648; D064704:Levofloxacin; D015242:Ofloxacin; D017291:Clarithromycin