A new role for enteric glucagon-37: acute stimulation of glucose absorption in rat small intestine.
Glucagon-37 is secreted by intestinal L-cells following carbohydrate uptake. It is known to inhibit gastric acid secretion (hence also named oxyntomodulin) and appears to increase intracellular cyclic AMP concentrations. Since cyclic AMP could enhance intestinal glucose absorption, a possible stimulatory effect of glucagon-37 on glucose transport was examined. Glucagon-37 acutely increased glucose absorption in the isolated, vascularly perfused small intestine and in isolated enterocytes of the rat. In these cells the stimulation by glucagon-37 could be completely blocked by the cAMP antagonist Rp-cAMPS and was therefore mediated by cAMP. The stimulation of intestinal glucose absorption by glucagon-37 appears to be a major new physiological function.
Stümpel
F
F
Institut für Biochemie und Molekulare Zellbiologie, Georg-August-Universität, Göttingen, Germany. fstuemp@gwdg.de
Scholtka
B
B
Jungermann
K
K
D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism; D004763:Glucagon-Like Peptides / Q000494:pharmacology / Q000502:physiology*; D005947:Glucose / Q000493:pharmacokinetics*; D066298:In Vitro Techniques; D007408:Intestinal Absorption; D007421:Intestine, Small / Q000378:metabolism*; D008297:Male; D053772:Oxyntomodulin; D051381:Rats; D017208:Rats, Wistar
D053772:Oxyntomodulin; D004763:Glucagon-Like Peptides; D000242:Cyclic AMP; D005947:Glucose