title: [Incidence and prognostic significance of epithelioid cell reactions and microcarcinoses in regional lymph nodes in stomach carcinoma].
abstract: The frequency and prognostic relevance of sarcoid-like lesions and microcarcinosis in regional lymph nodes in gastric cancer (n = 113; pT1-3, pN0-1, pM0, R0) were investigated; the prognostic value was compared with pT and pN stage, grading and Laurén's tumor classification with Cox's multivariate regression-model. Sarcoid like lesions were found in 34% of the cases (n = 113). Statistical analysis did not indicate that they had any prognostic value or showed whether or not microcarcinosis or metastasis was present; they were independent of pT stage, histological tumor type, tumor grading, and the clinical course of disease. Microcarcinosis (defined as scattered carcinoma cells within lymph node sinuses or pulp without adjacent stromal reaction) was revealed by immunohistochemistry in 90% of pN0 cases; the presence of 3 or more tumor cells per lymph node section in over 10% of sampled lymph nodes per case carried a significant prognostic value. In microcarcinosis without evidence of metastasis, the number of tumor cells and the number of involved lymph nodes are of prognostic value. In pN1 cases microcarcinosis was found as well as the metastases in 97% and had no additional prognostic value. Microcarcinosis alone has a different significance from lymph node metastasis for prognosis.
authors.affiliation: Institut für Allgemeine Pathologie und Pathologische Anatomie der Technischen Universität München.
authors.forename: R
authors.initials: R
authors.lastname: Kestlmeier
authors.forename: R
authors.initials: R
authors.lastname: Busch
authors.forename: C
authors.initials: C
authors.lastname: Fellbaum
authors.forename: K
authors.initials: K
authors.lastname: Boettcher
authors.forename: U
authors.initials: U
authors.lastname: Reich
authors.forename: J R
authors.initials: JR
authors.lastname: Siewert
authors.forename: H
authors.initials: H
authors.lastname: Höfler
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology* / Q000601:surgery; D014408:Biomarkers, Tumor / Q000032:analysis; D004848:Epithelium / Q000473:pathology; D006801:Humans; D007124:Immunoenzyme Techniques; D008197:Lymph Node Excision; D008198:Lymph Nodes / Q000473:pathology* / Q000601:surgery; D008207:Lymphatic Metastasis; D009367:Neoplasm Staging; D011379:Prognosis; D013154:Spleen / Q000473:pathology; D013160:Splenic Neoplasms / Q000473:pathology / Q000556:secondary; D013270:Stomach / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor
vernacular_title: Häufigkeit und prognostische Bedeutung von epitheloidzelligen Reaktionen und Mikrokarzinosen in den regionären Lymphknoten beim Magenkarzinom.