title: The initial Australian experience of technetium-99M sestamibi scintimammography: a complementary test in the management of breast cancer.
abstract: BACKGROUND
  The adjunctive role of Tc-99m sestamibi scintimammography in the diagnosis and management of patients with a high probability of breast cancer was assessed.
  
  
  METHODS
  A descriptive study of 16 patients with palpable masses who had a high probability of breast cancer as determined by investigations such as cytology and conventional imaging techniques were carried out. All patients were followed-up to surgery.
  
  
  RESULTS
  Scintimammography true positive results were found in 14 of 18 lesions detected in 16 patients. There were two false-positives which included one lobar carcinoma in situ lesion and one complex sclerosing lesion, and one false-negative patient. Scintimammography detected abnormal radiotracer uptake in four of six patients with axillary metastases. Three patients had clinically and mammographically undetected multicentric disease detected on scintimammography which allowed appropriate modification of surgical excision. Breast cancer was detected in a patient with breast prostheses.
  
  
  CONCLUSIONS
  Scintimammography would appear to have a useful adjunctive role to mammography in the diagnosis of breast cancer. The diagnosis of breast cancer may be enhanced in difficult cases and the detection of multicentricity on scintimammography may have an impact on subsequent surgical management.
authors.affiliation: Christo Road Breast Centre, Newcastle, New South Wales, Australia.
authors.forename: R
authors.initials: R
authors.lastname: Sillar
authors.forename: D
authors.initials: D
authors.lastname: Howarth
authors.forename: D
authors.initials: D
authors.lastname: Clark
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008327:Mammography / Q000379:methods*; D008875:Middle Aged; D009367:Neoplasm Staging; D018579:Patient Selection; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D017256:Technetium Tc 99m Sestamibi
chemical_list: D019275:Radiopharmaceuticals; D017256:Technetium Tc 99m Sestamibi