title: Calcium supplementation and the risk of preeclampsia in Ecuadorian pregnant teenagers.
abstract: OBJECTIVE
  To determine whether increased calcium intake (2 g/day) in pregnancy is effective in reducing the risk of preeclampsia in pregnant teenagers.
  
  
  METHODS
  The present study was a prospective, randomized, double-blind, controlled clinical trial. Two hundred sixty teenaged pregnant girls attending the Hospital Gíneco-Obstétrico Isidro Ayora in Quito, Ecuador, were included. Selection criteria were age less than 17.5 years, nulliparity, first prenatal visit before 20 weeks' gestation, and residency in Quito (2800-m altitude). We used a table of random numbers to assign 125 girls to receive 2000 mg of elemental calcium daily, beginning at 20 weeks of gestation and continuing until delivery; 135 women in the control group received a placebo. Blood pressure (BP) was measured twice every 4 weeks until delivery and at 48 hours after delivery. The diagnosis of preeclampsia was defined as BP greater than 140/90 mmHg on at least two occasions more than 6 hours apart and proteinuria greater than 30 mg/dL (over one cross by dipstick on two occasions 4-24 hours apart).
  
  
  RESULTS
  The average daily calcium intake in this population was approximately 51% of the Recommended Dietary Allowance. Calcium supplementation was associated with a significantly decreased risk of preeclampsia (risk reduction 12.35%; P < .001), with 3.2% (n = 4) developing preeclampsia in the treatment group versus 15.5% (n = 21) in the placebo group. Moreover, calcium supplementation led to a reduction in systolic BP of 9.1 mmHg and in diastolic BP of 6.0 mmHg.
  
  
  CONCLUSIONS
  These results suggest that calcium supplementation during pregnancy in populations with low calcium intake is a safe, effective, and inexpensive preventive measure that significantly reduces the risk of preeclampsia.
authors.affiliation: Mineral Metabolism Unit, Faculty of Medicine, Central University of Ecuador, Quito, Ecuador. lopezjar@pi.pro.ec
authors.forename: P
authors.initials: P
authors.lastname: López-Jaramillo
authors.forename: F
authors.initials: F
authors.lastname: Delgado
authors.forename: P
authors.initials: P
authors.lastname: Jácome
authors.forename: E
authors.initials: E
authors.lastname: Terán
authors.forename: C
authors.initials: C
authors.lastname: Ruano
authors.forename: J
authors.initials: J
authors.lastname: Rivera
mesh_terms: D000293:Adolescent; D001794:Blood Pressure / Q000187:drug effects; D002119:Calcium Carbonate / Q000627:therapeutic use*; D002136:Calcium, Dietary / Q000008:administration & dosage; D004311:Double-Blind Method; D004484:Ecuador / Q000453:epidemiology; D005260:Female; D006801:Humans; D015994:Incidence; D011225:Pre-Eclampsia / Q000453:epidemiology / Q000517:prevention & control*; D011247:Pregnancy; D011446:Prospective Studies; D012307:Risk Factors
chemical_list: D002136:Calcium, Dietary; D002119:Calcium Carbonate