title: The bigger the burn, the greater the stress.
abstract: Data characterizing the endocrine stress response to burn injury in children are sparse. We have measured the levels of the stress hormones arginine vasopressin, catecholamines-adrenaline, noradrenaline and dopamine-atrial natriuretic peptide and hormones of the renin-angiotensin-aldosterone system in admission blood samples taken from 35 children admitted to the burns unit of the regional children's hospital. Hormone levels were compared with the size of burn injury. With the exception of adrenaline, there were significant positive correlations between vasopressin (r = 0.707, p < 0.0001), plasma renin activity (r = 0.721, P < 0.0001), angiotensin II (r = 0.512, P = 0.002), aldosterone (r = 0.620, P < 0.0001), noradrenaline (r = 0.430, P = 0.0189), dopamine (r = 0.627, P = 0.0024) and percentage burn surface area, and a negative correlation between atrial natriuretic peptide (r = 0.548, P = 0.0008) and burn surface area. It is concluded that the hormones which react to stress are very sensitive to burn injury in children, and that the magnitude of their response is closely related to the size of the burn surface area.
authors.affiliation: Department of Child Life and Health, University of Edinburgh, UK.
authors.forename: A
authors.initials: A
authors.lastname: Smith
authors.forename: C
authors.initials: C
authors.lastname: Barclay
authors.forename: A
authors.initials: A
authors.lastname: Quaba
authors.forename: K
authors.initials: K
authors.lastname: Sedowofia
authors.forename: R
authors.initials: R
authors.lastname: Stephen
authors.forename: M
authors.initials: M
authors.lastname: Thompson
authors.forename: A
authors.initials: A
authors.lastname: Watson
authors.forename: N
authors.initials: N
authors.lastname: McIntosh
mesh_terms: D001127:Arginine Vasopressin / Q000097:blood; D009320:Atrial Natriuretic Factor / Q000097:blood; D002056:Burns / Q000097:blood / Q000150:complications*; D002395:Catecholamines / Q000097:blood; D002648:Child; D002675:Child, Preschool; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D007223:Infant; D011863:Radioimmunoassay; D012084:Renin-Angiotensin System / Q000502:physiology; D012720:Severity of Illness Index; D013312:Stress, Physiological / Q000097:blood / Q000209:etiology*
chemical_list: D002395:Catecholamines; D001127:Arginine Vasopressin; D009320:Atrial Natriuretic Factor