Fatal massive liver steatosis--a clinicopathological case report.
Hepatic fatty change is a common lesion. Two forms are recognized: micro- and macrovesicular steatosis, the former being much less frequent and more serious than the latter. The case of an alcoholic woman under anticonvulsivant therapy and with medications for a syndrome of inappropriate secretion of antidiuretic hormone (SIADH) who presented with rapidly progressive cholestasis and hepatocellular failure is reported. Massive macro- and micro-vesicular hepatic steatosis was diagnosed at autopsy. The authors review the clinico-pathological features associated with this condition, and causal factors possibly implicated in this case are discussed in regard with currently considered pathophysiological mechanisms.
de Leval
L
L
Department of Pathology, CHU of Liège, Belgium.
Lambermont
B
B
D'Orio
V
V
Boniver
J
J
D000900:Anti-Bacterial Agents / Q000009:adverse effects; D000927:Anticonvulsants / Q000009:adverse effects; D003707:Demeclocycline / Q000009:adverse effects; D017809:Fatal Outcome; D005235:Fatty Liver, Alcoholic / Q000097:blood / Q000209:etiology / Q000473:pathology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D010672:Phenytoin / Q000009:adverse effects
D000900:Anti-Bacterial Agents; D000927:Anticonvulsants; D003707:Demeclocycline; D010672:Phenytoin