title: Facilitated analysis of data on drug regimen compliance.
abstract: Drug actions depend on dose and intervals between doses, in ways that are drug-specific and sometimes complex, complicating the use of drug dosing histories as an explanatory variable in the analysis of clinical trials. We describe a spread-sheet method for conveniently displaying patients' drug dosing histories, to facilitate identification of dosing correlates of clinically important events.
authors.affiliation: Department of Internal Medicine, University Hospital Maastricht, The Netherlands.
authors.forename: E
authors.initials: E
authors.lastname: de Klerk
authors.forename: S
authors.initials: S
authors.lastname: van der Linden
authors.forename: D
authors.initials: D
authors.lastname: van der Heijde
authors.forename: J
authors.initials: J
authors.lastname: Urquhart
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D017326:Clinical Trials, Phase III as Topic; D004282:Documentation / Q000379:methods*; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D016903:Drug Monitoring / Q000379:methods*; D006801:Humans; D015337:Multicenter Studies as Topic; D010349:Patient Compliance; D013167:Spondylitis, Ankylosing / Q000188:drug therapy
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal