Aphrodisiac property of Trichopus zeylanicus extract in male mice.
Administration of Trichopus zeylanicus leaf (ethanol extract) to male mice stimulated their sexual behaviour as evidenced by an increase in number of mounts and mating performance. This activity of the ethanol extract was concentration dependent and destroyed by heat treatment at 100 degrees C for 15 min. Although oral administration of a single dose (200 mg/kg) was effective, daily administration of the extract for 6 days was found to be more effective. The pups fathered by the drug treated mice were found to be normal with reference to foetal growth, litter size and sex ratio. The water as well as n-hexane extracts of the plant leaf were inactive. The present study reveals for the first time the aphrodisiac activity of Trichopus zeylanicus, an endemic herb of India.
Subramoniam
A
A
Division of Ethnomedicine and Ethnopharmacology, Tropical Botonic Garden and Research Institute, Pacha-Palode, Kerala State, India.
Madhavachandran
V
V
Rajasekharan
S
S
Pushpangadan
P
P
D000818:Animals; D001046:Aphrodisiacs / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005298:Fertility / Q000187:drug effects; D008098:Litter Size / Q000187:drug effects; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D012744:Sex Ratio; D012726:Sexual Behavior, Animal / Q000187:drug effects*
D001046:Aphrodisiacs; D010936:Plant Extracts