A possible role of the redox interactions in the dual, activatory and inhibitory, action of DPI 201-106 on the potential-dependent Na+ channels.
Dual, activatory and inhibitory, effects of a cardiotonic drug DPI 201-106 on Na+ channels were compared with the redox properties of the DPI itself and of the constituents of its molecule, indole and piperazine. The indole component accepted electrons from radical intermediates of the light excited dye; the piperazine part of DPI acted as an electron donor in the same radical reactions. These data extend the previously obtained results which characterized organic blockers of Na+ and Ca2+ channels as electron donors, whereas activators of these channels were shown to be electron acceptors in test radical reactions. The whole DPI 201-106 molecule revealed both the electron-donor and electron-acceptor activity. The described electrophysiological effects of this compound (G. Wang et al., 1989) are discussed within the framework of the Na+ channel redox model (B. Marinov, 1991).
Marinov
B S
BS
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region.
D000494:Allosteric Regulation; D002316:Cardiotonic Agents / Q000494:pharmacology*; D007211:Indoles / Q000737:chemistry; D009211:Myoglobin / Q000737:chemistry / Q000378:metabolism; D009243:NAD / Q000378:metabolism; D010083:Oxidants, Photochemical / Q000737:chemistry; D010084:Oxidation-Reduction / Q000187:drug effects; D000077489:Piperazine; D010879:Piperazines / Q000737:chemistry / Q000494:pharmacology*; D026941:Sodium Channel Blockers; D015222:Sodium Channels / Q000187:drug effects* / Q000378:metabolism; D013237:Stereoisomerism
D002316:Cardiotonic Agents; D007211:Indoles; D009211:Myoglobin; D010083:Oxidants, Photochemical; D010879:Piperazines; D026941:Sodium Channel Blockers; D015222:Sodium Channels; D009243:NAD; D000077489:Piperazine; C030374:indole; C046261:DPI 201-106