title: Exchange transfusion in septic neonates with sclerema: effect on immunoglobulin and complement levels.
abstract: OBJECTIVE
  To study the effect of exchange transfusion (ET) on the levels of immunoglobulins (Ig) and C3 in neonatal sepsis with sclerema.
  
  
  METHODS
  Randomized controlled trial in a referral neonatal unit of a teaching hospital.
  
  
  METHODS
  Consecutive culture positive septic neonates with sclerema were enrolled and were randomized to undergo ET (study group, n = 20) or no ET (controls, n = 20).
  
  
  RESULTS
  Mortality was 50% in the study group and 95% in controls. Gram negative organisms accounted for 85% in study group and 90% in controls. IgG, IgA and IgM levels rose significantly while C3 levels did not show significant rise 12-24 hours after ET. Ig and C3 levels did not change significantly in the controls.
  
  
  CONCLUSIONS
  ET with fresh whole blood in septicemic newborns with sclerema improves survival, particularly in the more premature group and significantly enhances, IgG, IgA and IgM levels.
authors.affiliation: Department of Pediatrics, Maulana Azad Medical College, New Delhi.
authors.forename: S
authors.initials: S
authors.lastname: Sadana
authors.forename: N B
authors.initials: NB
authors.lastname: Mathur
authors.forename: A
authors.initials: A
authors.lastname: Thakur
mesh_terms: D016470:Bacteremia / Q000150:complications / Q000628:therapy*; D003165:Complement System Proteins / Q000378:metabolism*; D005078:Exchange Transfusion, Whole Blood; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000097:blood*; D007231:Infant, Newborn; D007234:Infant, Premature; D008297:Male; D012593:Sclerema Neonatorum / Q000150:complications / Q000628:therapy*; D018709:Statistics, Nonparametric; D015996:Survival Rate
chemical_list: D007136:Immunoglobulins; D003165:Complement System Proteins