Synthesis and antiparasitic activities of amidinic azolated derivatives.
A set of heterocyclic N-acetamidinium hydrochlorides were prepared from the corresponding N-acetonitriles. The antiparasitic screening showed that, while all amidines are practically inactive, some nitriles present leishmanicide properties.
Danan
A
A
URA 1116 CNRS, Faculté de Pharmacie, Châtenay-Malabry, France.
Charon
D
D
Kirkiacharian
S
S
Bories
C
C
Loiseau
P M
PM
D000097:Acetonitriles / Q000138:chemical synthesis / Q000494:pharmacology*; D000578:Amidines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D000981:Antiprotozoal Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D007893:Leishmania donovani / Q000187:drug effects; D018320:Leishmania major / Q000187:drug effects; D015394:Molecular Structure; D017172:Rhabditoidea / Q000187:drug effects; D014246:Trichomonas vaginalis / Q000187:drug effects
D000097:Acetonitriles; D000578:Amidines; D000981:Antiprotozoal Agents; C023731:acetamidine