title: Ultrasound in the detection of breast cancer associated with isolated clustered microcalcifications, mammographically identified.
abstract: The purpose of this work was to evaluate the effectiveness of US scanning in detecting breast cancer associated with isolated clustered microcalcifications (MC) mammographically identified. 52 isolated clusters of MC mammographically detected underwent histological examination. In all cases, ultrasonographic of (US) and cytologic examinations were performed for the improved definition of the nature of the MC. Fine needle aspiration was performed under radiographical (Rx)-guidance, only in cases of US-negativity. Ultrasound detected a breast lesion in 31 cases, out of which 24 (77.4%) were found to be carcinomas (invasive in 87.5% of the cases). Out of the remaining 21 US-negative cases, 7 (33.3%) were malignant lesions (15% invasive). Statistical analysis demonstrated that US-positivity significantly correlated with the presence of malignant lesions (p < 0.001). US-examination should also be performed in cases of isolated clustered microcalcifications for a more accurate selection of cases requiring histological verification.
authors.affiliation: Servizio Speciale Diagnosi, Prevenzione e Cura Tumori I Clinica Chirurgica, Policlinico Umberto I, Universitá La Sapienza, Roma, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Ranieri
authors.forename: M R
authors.initials: MR
authors.lastname: D'Andrea
authors.forename: A
authors.initials: A
authors.lastname: D'Alessio
authors.forename: S
authors.initials: S
authors.lastname: Bergomi
authors.forename: G
authors.initials: G
authors.lastname: Caprio
authors.forename: G B
authors.initials: GB
authors.lastname: Calabrese
authors.forename: F
authors.initials: F
authors.lastname: Virno
mesh_terms: D000328:Adult; D000368:Aged; D001707:Biopsy, Needle; D001941:Breast Diseases / Q000000981:diagnostic imaging*; D001943:Breast Neoplasms / Q000000981:diagnostic imaging*; D002114:Calcinosis / Q000000981:diagnostic imaging*; D002278:Carcinoma in Situ / Q000175:diagnosis*; D018270:Carcinoma, Ductal, Breast / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008327:Mammography / Q000379:methods*; D008875:Middle Aged; D014463:Ultrasonography