title: Arteriovenous fistula combined with basal external penile compression: a new cure for male impotence.
abstract: We describe here a new procedure designed to enable reproducible sustained erection in a canine model. In 10 dogs, an end-to-side arteriovenous fistula was created between the inferior epigastric artery and deep dorsal vein. A chronic skin tunnel was created at the penile base. Blood flow, intracavernosal pressure and intraspongiosal pressure and blood gases were measured initially and 3 months later. Cuff application for 30 minutes was used daily. At 3 months, animals were sacrificed and biopsies obtained. Physiologic and histological parameters of erectile structures remained unchanged. Intracavernosal and intraspongiosal pressures increased to 33.7 +/- 6.7 mm Hg and 25.3 +/- 12.2 mm Hg (from 8.0 +/- 2.9 and 6.0 +/- 3.6 mm Hg) after cuff application. We conclude that sustained erections are feasible. This procedure appears safe for human trials.
authors.affiliation: Department of Surgery, North Oakland Medical Centers, Pontiac, Michigan 48341, USA.
authors.forename: V
authors.initials: V
authors.lastname: Godziachvili
authors.forename: A
authors.initials: A
authors.lastname: Saba
authors.forename: J
authors.initials: J
authors.lastname: Libcke
authors.forename: A
authors.initials: A
authors.lastname: Kumar
authors.forename: Y
authors.initials: Y
authors.lastname: Silva
mesh_terms: D000714:Anastomosis, Surgical; D000818:Animals; D001166:Arteriovenous Shunt, Surgical; D001706:Biopsy; D001794:Blood Pressure; D002245:Carbon Dioxide / Q000097:blood; D003250:Constriction; D003287:Contrast Media; D062109:Dermatologic Surgical Procedures; D003973:Diatrizoate; D003974:Diatrizoate Meglumine; D004195:Disease Models, Animal; D004285:Dogs; D004338:Drug Combinations; D019074:Epigastric Arteries / Q000000981:diagnostic imaging / Q000601:surgery; D007172:Erectile Dysfunction / Q000601:surgery*; D005240:Feasibility Studies; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D010100:Oxygen / Q000097:blood; D010410:Penile Erection; D010413:Penis / Q000098:blood supply* / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D011312:Pressure; D011859:Radiography; D012039:Regional Blood Flow; D015203:Reproducibility of Results; D012449:Safety; D012611:Scrotum / Q000601:surgery; D014654:Vascular Patency; D014680:Veins / Q000601:surgery
chemical_list: D003287:Contrast Media; D004338:Drug Combinations; D003973:Diatrizoate; D002245:Carbon Dioxide; D003974:Diatrizoate Meglumine; C027278:urovision; D010100:Oxygen