Spectral analysis of a thalamus-to-cortex seizure pathway.
Physiological evidence has shown that the anterior thalamus (AN) and its associated efferents/afferents constitute an important propagation pathway for one animal model of generalized tonic-clonic epileptic seizures. In this study we extend and confirm the support for AN's role by examining neuroelectric signal indicators during seizure episodes. We show that the electroencephalogram (EEG) recorded from AN is highly coherent with the EEG derived from the cortex (CTX). By removing the effects of another thalamic nucleus, posterior thalamus (PT)-unaffiliated with the tract linking AN to cortex-partial coherence analysis leaves the CTX/AN coherence undiminished. The most robust band of strong CTX-AN coherence is centered around the spike-wave pacing frequency of 1-3 Hz. Partial-multiple coherence analysis techniques are used to remove the possible signal contribution from hippocampus in addition to PT. The CTX-AN coherence still remains undiminished in the low-frequency bands. Conclusive evidence from coherence studies and other spectral measures reaffirm the special role of the AN in the propagation of seizure activity from subcortex to cortex.
Sherman
D L
DL
Department of Biomedical Engineering, Johns Hopkins School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA. dsherman@bme.jbu.edu
Tsai
Y C
YC
Rossell
L A
LA
Mirski
M A
MA
Thakor
N V
NV
D000703:Analog-Digital Conversion; D000704:Analysis of Variance; D000818:Animals; D002540:Cerebral Cortex / Q000503:physiopathology*; D004569:Electroencephalography; D004827:Epilepsy / Q000175:diagnosis*; D008297:Male; D008959:Models, Neurological; D051381:Rats; D017207:Rats, Sprague-Dawley; D012640:Seizures / Q000503:physiopathology*; D012815:Signal Processing, Computer-Assisted; D013788:Thalamus / Q000503:physiopathology*