[The activity of the lipid peroxidation processes in the mucosa of the rat small intestine and its morphofunctional state under acute irradiation and the administration of combined preparations created on a base of highly dispersed silica].
Morphofunctional and biochemical studies were carried out on bastard male rats (weight 200-240 g). The results showed that X-ray irradiation had induced structural alterations and elevation of lipid peroxidation in small intestine. Using of complex preparations defended this organ against pathological damages. The first preparation provided rat organisms with 100 ml/kg of silica, 2 mg/kg of beta-carotene, 30 mg/kg of alpha-tocopherol and 0.2 mg/kg of natrium selenite. The second preparation provided 100 mg/kg of silica, 10 mg/kg of dry Rhodiola extract, 0.1 mg/kg of tincture of Lagochilus [correction of Ladohilli] inebrians and 0.05 ml/kg of tincture of Aralia mandshurica. The third preparation provided organism with 100 mg/kg of silica and 20 mg/kg of thiobenzimidazole derivative. All these preparations had produced marked pharmacological effect.
Iakubovskiĭ
M M
MM
Pentiuk
A A
AA
Khmelnitskiĭ
O K
OK
Oleĭnik
V N
VN
D000208:Acute Disease; D000818:Animals; D004337:Drug Carriers; D004338:Drug Combinations; D004353:Drug Evaluation, Preclinical; D007413:Intestinal Mucosa / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology / Q000528:radiation effects; D007421:Intestine, Small / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology / Q000528:radiation effects; D015227:Lipid Peroxidation / Q000187:drug effects* / Q000528:radiation effects; D008297:Male; D011108:Polymers; D011833:Radiation Injuries, Experimental / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D051381:Rats; D012822:Silicon Dioxide; D013997:Time Factors
D004337:Drug Carriers; D004338:Drug Combinations; D011108:Polymers; C048851:polysorb; D012822:Silicon Dioxide
Aktivnost' protsessov perekisnogo okisleniia lipidov v slizistoĭ obolochke tonkoĭ kishki krys i ee morfofunktsional'noe sostoianie v usloviiakh ostrogo oblucheniia i vvedeniia kombinirovannykh preparatov, sozdannykh na osnove vysokodispersnogo kremnezema.