Changes in bone mineral density in rat adjuvant arthritis.
This study demonstrates that systemic and local decreases in bone mineral density (BMD) occurred with Freund's complete adjuvant injection in the rat right footpad using dual energy X-ray absorptiometry. The rats were assigned to either adjuvant-treated or non-treated control groups composed of eight animals each. There was significant decrease in BMD in the adjuvant group compared to the control group at the distal region of femur or proximal region of tibia on Day 7 post-adjuvant injection (P < 0.05). On the other hand, the femur or tibia of the noninjected side showed a smaller and delayed decrease in BMD than did the injected side. These decreases in BMD were seen in not only the trabecular but also the cortical bone. In addition, the vertebrae also showed delayed but significant decrease (P < 0.05) in BMD on Day 21.
Takagi
T
T
Tanabe Seiyaku Co. Ltd., Lead Optimization Research Laboratory, Saitama, Japan.
Tsao
P W
PW
Totsuka
R
R
Suzuki
T
T
Murata
T
T
Takata
I
I
D000818:Animals; D001169:Arthritis, Experimental / Q000503:physiopathology*; D001835:Body Weight / Q000502:physiology; D015519:Bone Density / Q000502:physiology*; D004195:Disease Models, Animal; D004487:Edema / Q000209:etiology; D005260:Female; D005269:Femur / Q000737:chemistry; D005528:Foot; D051381:Rats; D011917:Rats, Inbred Lew; D013131:Spine / Q000737:chemistry; D013977:Tibia / Q000737:chemistry