Generalized drug reaction due to papaya juice in throat lozenges.
We report the case of a 55-year-old woman without a history of atopic disease or drug allergy who developed a maculopapular symmetric exanthematous rash about 2 days after taking throat lozenges containing papaya juice. Patch tests gave negative reactions to the European standard series but were positive for papaya juice. A solution of 1% papain in water showed a weak and probably irritant reaction, while a 0.1% solution was negative. To our knowledge this is the first case report of systemic contact dermatitis to papaya without papain hypersensitivity.
Iliev
D
D
Department of Dermatology, University Hospital Zurich, Switzerland.
Elsner
P
P
D003875:Drug Eruptions / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D004342:Drug Hypersensitivity / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D005260:Female; D006801:Humans; D007827:Laryngitis / Q000188:drug therapy; D008875:Middle Aged; D010206:Papain / Q000009:adverse effects* / Q000627:therapeutic use; D010328:Patch Tests; D010936:Plant Extracts / Q000009:adverse effects* / Q000627:therapeutic use
D010936:Plant Extracts; D010206:Papain