Azithromycin in the treatment of chlamydial cervicitis and eradication of Ureaplasma urealyticum in female lower genital tract.
From May 1995 to May 1996, thirty-six females with chlamydial cervicitis were enrolled at Bangrak Hospital's Venereal Disease Clinic in an open study to assess the efficacy and safety of a single, 1-gram oral dose of azithromycin. Thirty-five had positive C. trachomatis and one had a positive Gen-probe test. Twenty-two returned for their first and second follow-ups and 18 came back for their final follow-up (visit 4). Eradication rate was 100 per cent on all visits. Fourteen patients were excluded from the final analysis- three had dropped out from the beginning, ten had sexual intercourse without a condom and one had a positive Gen-probe test but negative C. trachomatis culture. U. urealyticum was isolated from the vaginal wall of 15 of the 36 cases and eradication rate was 0 per cent at visit 2 and visit 4. In conclusion, this study shows that a single, 1-gram oral dose of azithromycin is an effective and well-tolerated alternative therapy for chlamydial cervicitis.
Charoenwatanachokchai
A
A
Department of Communicable Disease Control, Ministry of Public Health, Bangkok, Thailand.
Chitwarakorn
A
A
Siriwongrangsun
P
P
Pariyasak
W
W
Yenyasun
N
N
Sukwit
S
S
D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D017963:Azithromycin / Q000627:therapeutic use*; D002690:Chlamydia Infections / Q000188:drug therapy*; D002692:Chlamydia trachomatis / Q000302:isolation & purification*; D005260:Female; D006801:Humans; D016896:Treatment Outcome; D016869:Ureaplasma Infections / Q000188:drug therapy*; D016990:Ureaplasma urealyticum / Q000302:isolation & purification*; D002575:Uterine Cervicitis / Q000188:drug therapy* / Q000382:microbiology; D014621:Vagina / Q000382:microbiology
D000900:Anti-Bacterial Agents; D017963:Azithromycin