Bone marrow transplantation from unrelated volunteer donors. An overview.
Marrow transplantation from a phenotypically identical unrelated donor has become a feasible and curative form of treatment for patients with several malignant and nonmalignant disorders who lack an HLA-matched sibling donor. Given the rapid growth of registries of HLA-typed volunteers-including nearly 3,000,000 people-it is now possible to identify a suitable unrelated marrow donor for up to 50% of patients. In this review the recent acquisitions regarding the structure of HLA complex, the new molecular typing technologies and clinical results obtained with unrelated marrow transplants, will be considered.
Busca
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A
Department of Pediatrics, University of Turin, Italy.
Amoroso
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A
Miniero
R
R
D016026:Bone Marrow Transplantation / Q000276:immunology*; D006801:Humans; D010641:Phenotype; D014019:Tissue Donors; D016896:Treatment Outcome