Interaction of genetic and exposure factors in the prevalence of berylliosis.
Prevalence of berylliosis, a lung disorder driven by the activation of beryllium-specific T cells, is associated with a major histocompatibility complex (MHC) class II marker (HLA-DPB1Glu69) and with the type of industrial exposure. We evaluated the interaction between marker and exposure in a beryllium-exposed population in which the prevalence of berylliosis was associated with machining beryllium. The presence of the marker was associated with higher prevalence (HLA-DPB1Glu69-positive machinists 25%; HLA-DPB1Glu69-negative machinists 3.2%, P = 0.05) and predicted berylliosis independent of machining history (odds ratios 11.8 and 10.1). The study shows that in berylliosis the carrier status of a genetic susceptibility factor adds to the effect of process-related risk factors.
Richeldi
L
L
Department of Medical Sciences, University of Modena, Italy.
Kreiss
K
K
Mroz
M M
MM
Zhen
B
B
Tartoni
P
P
Saltini
C
C
D000328:Adult; D001607:Berylliosis / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D005819:Genetic Markers; D006682:HLA-DP Antigens; D006801:Humans; D016015:Logistic Models; D008297:Male; D008669:Metallurgy; D016273:Occupational Exposure; D015345:Oligonucleotide Probes; D016133:Polymerase Chain Reaction; D015995:Prevalence; D012307:Risk Factors; D018709:Statistics, Nonparametric; D014481:United States / Q000453:epidemiology
D005819:Genetic Markers; D006682:HLA-DP Antigens; D015345:Oligonucleotide Probes