title: Does thiopentone delay recovery in children premedicated with midazolam?
abstract: This prospective, randomized trial of paediatric surgical outpatients, premedicated with oral midazolam, was designed to determine if an intravenous thiopentone induction of anaesthesia prolongs postoperative recovery compared to an inhalation induction with halothane. One hundred children, one to ten years of age, undergoing ENT surgical procedures of 30-60 min duration received midazolam 0.5 mg.kg-1 with atropine 0.03 mg.kg-1 and were randomized to either halothane (Group 1, n = 50) or a thiopentone induction (Group 2, n = 50) technique, followed by a standardized anaesthetic-protocol. Time to extubation was significantly greater in the thiopentone group (8.8 +/- 4 min vs 7.1 +/- 3 min, P < 0.05). Patients receiving thiopentone were also more sedated than the halothane group on arrival in the PARR (3.9 +/- 1.5, 3.3 +/- 1.7, respectively P < 0.05), but the differences disappeared after 30 min. Children premedicated with oral midazolam who receive an intravenous thiopentone induction have a slightly prolonged emergence from anesthesia compared to children induced with halothane.
authors.affiliation: Department of Anesthesia, St. Joseph's Health Centre, University of Western Ontario, London, Canada.
authors.forename: P
authors.initials: P
authors.lastname: Morley-Forster
authors.forename: J D
authors.initials: JD
authors.lastname: McAllister
authors.forename: H
authors.initials: H
authors.lastname: Vandenberghe
authors.forename: J J
authors.initials: JJ
authors.lastname: Thiessen
authors.forename: A
authors.initials: A
authors.lastname: White
authors.forename: M
authors.initials: M
authors.lastname: Taylor
authors.forename: D C
authors.initials: DC
authors.lastname: Knoppert
mesh_terms: D000759:Adjuvants, Anesthesia / Q000008:administration & dosage; D000284:Administration, Oral; D000556:Ambulatory Surgical Procedures; D000762:Anesthesia Recovery Period; D000769:Anesthesia, Inhalation; D000771:Anesthesia, Intravenous; D018685:Anesthetics, Inhalation / Q000008:administration & dosage / Q000494:pharmacology; D018686:Anesthetics, Intravenous / Q000008:administration & dosage* / Q000494:pharmacology; D001285:Atropine / Q000008:administration & dosage; D002648:Child; D002675:Child, Preschool; D006221:Halothane / Q000008:administration & dosage / Q000494:pharmacology; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage* / Q000494:pharmacology; D007223:Infant; D007442:Intubation, Intratracheal; D008874:Midazolam / Q000008:administration & dosage* / Q000494:pharmacology; D011229:Preanesthetic Medication; D011446:Prospective Studies; D013874:Thiopental / Q000008:administration & dosage* / Q000494:pharmacology; D013997:Time Factors; D014851:Wakefulness / Q000187:drug effects
chemical_list: D000759:Adjuvants, Anesthesia; D018685:Anesthetics, Inhalation; D018686:Anesthetics, Intravenous; D006993:Hypnotics and Sedatives; D001285:Atropine; D013874:Thiopental; D008874:Midazolam; D006221:Halothane