Evaluation of growth promotion and inhibition from mycobactins and nonmycobacterial siderophores (Desferrioxamine and FR160) in Mycobacterium aurum.
Heterologous mycobactins and the synthetic FR160 [N4-nonyl,N1,N8-bis(2,3-dihydroxybenzoyl) spermidine hydrobromide (C3 0H4 6N3, O6 Br)] promoted growth in Mycobacterium aurum in low concentrations. They were otherwise highly inhibitory, as opposed to homologous mycobactin, which was strictly growth promoting. Desferrioxamine B (Desferal) had no significant effect on growth.
Bosne-David
S
S
Centro de Malária e outras Doenças Tropicais/IHMT/UNL, Lisbon, Portugal. cmdt@esoterica.pt
Bricard
L
L
Ramiandrasoa
F
F
DeRoussent
A
A
Kunesch
G
G
Andremont
A
A
D002455:Cell Division / Q000187:drug effects; D003676:Deferoxamine / Q000494:pharmacology*; D005069:Evaluation Studies as Topic; D009161:Mycobacterium / Q000187:drug effects*; D010080:Oxazoles / Q000494:pharmacology*; D017262:Siderophores / Q000494:pharmacology*; D013095:Spermidine / Q000031:analogs & derivatives* / Q000494:pharmacology; D013997:Time Factors
C108048:FR 160; D010080:Oxazoles; D017262:Siderophores; C018608:mycobactins; D003676:Deferoxamine; D013095:Spermidine