title: Aluminium in antacids and cooking pots and the risk of hip fractures in elderly people.
abstract: The relationship between hip fractures and aluminium in antacids and cooking pots was examined in an epidemiological study in Sydney, Australia. A population-based case-control study was conducted and 416 men and women aged 65 years and over were recruited (209 cases and 207 controls). There was a significantly (p < 0.05) increased risk of hip fracture associated with use of aluminium cooking pots at age 20 years: the age- and sex-adjusted odds ratio was 1.9 [95% confidence interval (CI) 1.1-3.2]. No association was detected between risk of hip fracture and current use of aluminium cooking pots or use at age 50. There was some suggestion that long-term use of aluminium-containing antacids might increase the risk of hip fracture: the adjusted odds ratio comparing those who had used aluminium-containing antacids for more than 10 years with those who had never used them was 1.8 (95% CI 0.8-4.1). The findings of this study support the need for further research on the association between oral ingestion of aluminium and risk of hip fracture.
authors.affiliation: Department of Public Health, University of Sydney, NSW, Australia.
authors.forename: R G
authors.initials: RG
authors.lastname: Cumming
authors.forename: R J
authors.initials: RJ
authors.lastname: Klineberg
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000535:Aluminum / Q000009:adverse effects* / Q000032:analysis; D000863:Antacids / Q000008:administration & dosage / Q000009:adverse effects*; D016022:Case-Control Studies; D003296:Cooking / Q000295:instrumentation*; D003430:Cross-Sectional Studies; D005260:Female; D006620:Hip Fractures / Q000139:chemically induced* / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009517:New South Wales / Q000453:epidemiology; D016017:Odds Ratio; D012307:Risk Factors; D012737:Sex Factors
chemical_list: D000863:Antacids; D000535:Aluminum