Tricompartmental kinetics of the organophosphorous pesticide dimethoate.
We present a study on the distribution and persistence of the organophosphorous pesticide, dimethoate, in the Wistar rat. Dimethoate's levels in blood and tissues were determined using gas chromatography with a NPD detector. The toxicokinetic profile was estimated by non-linear regression using the software program PCNONLIN, which concluded that a tricompartmental model best described dimethoate's behavior in the rat body.
Garcia-Repetto
R
R
Instituto Nacional de Toxicologia, Sevilla, Spain.
Martinez
D
D
Repetto
M
M
D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000378:metabolism; D002849:Chromatography, Gas; D004117:Dimethoate / Q000493:pharmacokinetics*; D006207:Half-Life; D007306:Insecticides / Q000493:pharmacokinetics*; D008099:Liver / Q000378:metabolism; D008297:Male; D018482:Muscle, Skeletal / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D014018:Tissue Distribution
D007306:Insecticides; D004117:Dimethoate