title: Dose perturbation due to the presence of a prostatic urethral stent in patients receiving pelvic radiotherapy: an in vitro study.
abstract: Temporary metallic intraprostatic stent is a new alternative treatment for patients with urinary obstructive syndrome caused by prostate cancer. Definitive radiotherapy is a treatment of choice for localized prostate cancer. This study evaluates in vitro the effect of a urethral intraprostatic metallic stent on the dose absorbed by the surrounding tissue. The study was designed to mimic the conditions under which the prostatic stent is placed in the body during pelvic irradiation. A urethral stent composed of a 50% nickel-50% titanium alloy (Uracoil-InStent) was imbedded in material mimicking normal tissue (bolus) at a simulated body depth of 10 cm. The distribution of the absorbed dose of irradiation was determined by film dosimetry using Kodak X-Omat V film. Irradiation was done in a single field at the isocenter of a 6 MV linear accelerator with a field size of 7 x 7 cm. The degree of film blackening was in direct proportion to the absorbed dose. The measurements showed an increase in dose of up to 20% immediately before the stent and a decrease of up to 18% immediately after the stent. These changes occurred within a range of 1-3 mm from both sides of the stent. In practice, irradiation in prostate cancer is given by two pairs of opposed co-axial fields; a total of four fields (Box Technique). The dose perturbations are partly cancelled in a pair of opposed beams resulting in a net variation of +/- 4%; therefore, the presence of the intraprostatic stent should not influence radiotherapy planning for prostate cancer.
authors.affiliation: Department of Oncology, Rambam Medical Center, Haifa, Israel.
authors.forename: E
authors.initials: E
authors.lastname: Gez
authors.forename: M
authors.initials: M
authors.lastname: Cederbaum
authors.forename: D
authors.initials: D
authors.lastname: Yachia
authors.forename: R
authors.initials: R
authors.lastname: Bar-Deroma
authors.forename: A
authors.initials: A
authors.lastname: Kuten
mesh_terms: D006801:Humans; D008297:Male; D008670:Metals; D010388:Pelvis / Q000528:radiation effects*; D019047:Phantoms, Imaging; D011471:Prostatic Neoplasms / Q000150:complications / Q000532:radiotherapy*; D011879:Radiotherapy Dosage; D015607:Stents; D014521:Urethra; D001748:Urinary Bladder Neck Obstruction / Q000209:etiology / Q000628:therapy
chemical_list: D008670:Metals