title: Increased intrapartum antibiotic administration associated with epidural analgesia in labor.
abstract: To determine whether women who receive continuous epidural analgesia for labor and delivery are more likely to receive antibiotic therapy compared to those parturients who do not use epidural analgesia, a chart review was performed for 300 women 100 in each group using narcotics alone epidural alone, or parenteral narcotics followed by epidural analgesia. While only 2% of women with narcotics alone developed an intrapartum temperature > or = 37.8 degrees C, 16% and 24% of women with epidural use alone or in addition to narcotics did so, respectively. Antibiotic administration was increased among women utilizing epidural analgesia, exclusively or following parenteral narcotics. No parturient with culture or pathological evidence of chorioamnionitis had maternal temperature elevation as an isolated finding. A probable causal relationship between maternal temperature elevation and epidural use in labor is supported. Rather than treating all women with temperature elevations and epidurals for presumed chorioamnionitis, it is reasonable to target treatment to those with fetal tachycardia, meconium stained fluid, or abnormal amniotic fluid studies.
authors.affiliation: Department of Anesthesiology, University of North Carolina, Chapel Hill 27599-7010, USA.
authors.forename: D C
authors.initials: DC
authors.lastname: Mayer
authors.forename: N C
authors.initials: NC
authors.lastname: Chescheir
authors.forename: F J
authors.initials: FJ
authors.lastname: Spielman
mesh_terms: D000328:Adult; D000653:Amniotic Fluid / Q000737:chemistry / Q000382:microbiology; D015360:Analgesia, Epidural; D016362:Analgesia, Obstetrical; D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002821:Chorioamnionitis / Q000382:microbiology / Q000473:pathology; D036861:Delivery, Obstetric; D005260:Female; D005315:Fetal Diseases / Q000209:etiology; D005334:Fever / Q000209:etiology; D006801:Humans; D007275:Injections, Intravenous; D007743:Labor, Obstetric; D008470:Meconium; D010920:Placenta / Q000382:microbiology; D011247:Pregnancy; D011336:Probability; D012189:Retrospective Studies; D013610:Tachycardia / Q000209:etiology
chemical_list: D000701:Analgesics, Opioid; D000900:Anti-Bacterial Agents