title: Sapheno-femoral valves. Histopathological observations and diagnostic approach before surgery.
abstract: BACKGROUND
  Since the literature indicated that in the early stages of primary venous disease valves are simply dilated, some authors performed external valvuloplasty of deep and superficial venous valves with encouraging results, although some failures were observed without being sufficiently explained.
  
  
  OBJECTIVE
  To obtain further interpretations of the natural history of venous valve pathology, clarify methods for a correct diagnostic approach, and provide indications for the external valvuloplasty procedure.
  
  
  METHODS
  Forty-two proximal valves of the long saphenous vein removed for varicose veins of the lower limbs were studied with optical microscopy. The relationship between histologic alterations and age of varicose disease was investigated. Five valvuloplasties were explanted for recurrent reflux and submitted to histopathological observation. Preoperative echographic findings and histologic observations were compared. Nineteen limbs were subjected to external valvuloplasty under angioscopic control; preoperative echographic findings and angioscopic observations were compared.
  
  
  RESULTS
  The histologic alterations observed in venous valves were mainly hypotrophy of cusps, which seemed to be the main cause of failure after external valvuloplasty. The frequency of such hypotrophic alterations increases with the age of varicose disease but no statistically significant relationship was found. Preoperative echographic imaging of venous valves does not appear sufficiently predictive when compared with histologic and angioscopic examinations.
  
  
  CONCLUSIONS
  Hypotrophic valve damage seems to be prevalent in patients with varicose veins of the lower limbs. Valve cusp hypotrophy may be present in early disease though some normal cusps can be found in advanced disease. When preoperative echographic visualization of cusps is doubtful, intraoperative angioscopy plays the main role in the diagnosis of venous valve disease before and during external valvuloplasty.
authors.affiliation: Department of Surgery, University of Sassari, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Corcos
authors.forename: T
authors.initials: T
authors.lastname: Procacci
authors.forename: G
authors.initials: G
authors.lastname: Peruzzi
authors.forename: M
authors.initials: M
authors.lastname: Dini
authors.forename: D
authors.initials: D
authors.lastname: De Anna
mesh_terms: D017546:Angioscopy; D001807:Blood Vessel Prosthesis; D005268:Femoral Vein / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007430:Intraoperative Care; D012501:Saphenous Vein / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D014463:Ultrasonography; D014648:Varicose Veins / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery