title: [Bacterial urovirulence factors and their association with functional and anatomical abnormalities and recurrence of urinary tract infections in children].
abstract: BACKGROUND
  Urinary tract infections in children are associated with functional and anatomical abnormalities of the urinary tract, they tend to recur and can cause permanent kidney damage.
  
  
  OBJECTIVE
  To study in children with urinary tract infections, microbiological factors associated to recurrence, functional and anatomical abnormalities of the urinary tract.
  
  
  METHODS
  A prospective sample of children was incorporated into a follow-up protocol after their first episode of bacteriologically-demonstrated urinary tract infection. In all patients an abdominal ultrasound examination and a mictional urethrocystography were done and the presence of fimbriae was studied in isolated strains of Escherichia coli.
  
  
  RESULTS
  Two hundred fifteen cases bad an adequate adherence to the study protocol, 190 caused by E coli. Fimbriated E coli strains were isolated with greater frequency from children with pyelonephritis than from those with a low urinary tract infection (50 and 28% respectively). The absence of fimbriae in E coli strains was associated with a higher risk of recurrent infections (odds ratio = 3, confidence intervals = 2-9.2) and an abnormal urethrocystography (odds ratio = 3, confidence intervals = 1.1-10.2).
  
  
  CONCLUSIONS
  These data are consistent with foreign reports and support the need to study adhesins in E coli strains isolated from children with urinary tract infections.
authors.affiliation: Hospital Roberto del Río, Servicio de Salud Metropolitana Norte.
authors.forename: R
authors.initials: R
authors.lastname: Lagos
authors.forename: P
authors.initials: P
authors.lastname: Herrera
authors.forename: A
authors.initials: A
authors.lastname: Sepúlveda
authors.forename: A
authors.initials: A
authors.lastname: Muñoz
authors.forename: C
authors.initials: C
authors.lastname: Benavente
authors.forename: I
authors.initials: I
authors.lastname: Bravo
authors.forename: T
authors.initials: T
authors.lastname: Lamberg
mesh_terms: D001424:Bacterial Infections / Q000382:microbiology*; D002648:Child; D002675:Child, Preschool; D004926:Escherichia coli / Q000302:isolation & purification*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D008297:Male; D011446:Prospective Studies; D012008:Recurrence; D014551:Urinary Tract / Q000002:abnormalities; D014552:Urinary Tract Infections / Q000382:microbiology* / Q000652:urine
vernacular_title: Factores de urovirulencia bacteriana: asociación con recurrencias y anomalías anatómicas y funcionales en niños con infección del tracto urinario.