[Inhibition of 5-fluorouracil-cisplatin-induced stomatitis by oral cryotherapy: use of an ice-bar containing fibrinolysin and deoxyribonuclease combine (Elase)].
Stomatitis caused by a combined chemotherapy with 5-fluorouracil (5-FU) and cisplatin (CDDP) is a serious problem in the course of treatment for patients with oral carcinoma. In the present study, we proposed a form of cryotherapy using an ice-bar containing fibrinolysin and deoxyribonuclease (Elase) to inhibit the stomatitis. The therapeutic effect of the ice-bar cryotherapy was evaluated in 20 patients with oral squamous cell carcinoma who were undergoing 5-FU-CDDP chemotherapy. Nine of the 20 patients were given the ice-bar cryotherapy while the remaining patients were not. As a result, although there was no significant difference between the incidence of stomatitis in the groups with and without the ice-bar cryotherapy, the incidence of severe stomatitis with ulcers and/or eating disturbance in the 11 cases without the ice-bar cryotherapy (90%) was significantly higher than that in the 9 cases with the cryotherapy (44%) (p < 0.05). However, no significant difference in the clinical response rate of the 5-FU-CDDP chemotherapy was observed between the two groups.
Sato
A
A
Dept. of Oral and Maxillofacial Surgery II, Tohoku University School of Dentistry.
Kumagai
S
S
Sakaki
K
K
Morikawa
H
H
Song
S T
ST
Mori
S
S
D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy*; D002945:Cisplatin / Q000009:adverse effects*; D017679:Cryotherapy; D003851:Deoxyribonucleases / Q000008:administration & dosage; D004338:Drug Combinations; D005260:Female; D005341:Fibrinolysin / Q000008:administration & dosage; D005472:Fluorouracil / Q000009:adverse effects*; D006801:Humans; D007053:Ice; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000188:drug therapy*; D013280:Stomatitis / Q000139:chemically induced / Q000628:therapy*
D004338:Drug Combinations; D007053:Ice; C021490:deoxyribonuclease, plasmin drug combination; D003851:Deoxyribonucleases; D005341:Fibrinolysin; D002945:Cisplatin; D005472:Fluorouracil