title: Micro-magnetic resonance imaging of the inner ear in the guinea pig.
abstract: We applied a magnetic resonance microscopy at 7.05 T with a gradient coil unit to image the fine structure of the guinea pig cochlea. First, a three-dimensional MR image of the surface of the cochlea was obtained to select the location of cross-sectional images. Then, cross-sectional images of the basal turn, the second turn and the apical turn of the cochlea were obtained. Based upon the different protein concentrations of the endolymph vs the perilymph, the scala vestibuli, scala tympani and the cochlear duct could be clearly distinguished. This allowed a determination of the location of both the basilar membrane and Reissner's membrane. We raise the possibility that MRM may become useful in the diagnosis of endolymphatic hydrops (Meniere's disease).
authors.affiliation: Department of Otolaryngology, St Marianna University School of Medicine, Kanagawa, Japan.
authors.forename: I
authors.initials: I
authors.lastname: Koizuka
authors.forename: Y
authors.initials: Y
authors.lastname: Seo
authors.forename: M
authors.initials: M
authors.lastname: Murakami
authors.forename: R
authors.initials: R
authors.lastname: Seo
authors.forename: I
authors.initials: I
authors.lastname: Kato
mesh_terms: D000818:Animals; D003051:Cochlea / Q000033:anatomy & histology*; D006168:Guinea Pigs; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods*