Pax6 controls progenitor cell identity and neuronal fate in response to graded Shh signaling.
Distinct classes of motor neurons and ventral interneurons are generated by the graded signaling activity of Sonic hedgehog (Shh). Shh controls neuronal fate by establishing different progenitor cell populations in the ventral neural tube that are defined by the expression of Pax6 and Nkx2.2. Pax6 establishes distinct ventral progenitor cell populations and controls the identity of motor neurons and ventral interneurons, mediating graded Shh signaling in the ventral spinal cord and hindbrain.
Ericson
J
J
Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, USA.
Rashbass
P
P
Schedl
A
A
Brenner-Morton
S
S
Kawakami
A
A
van Heyningen
V
V
Jessell
T M
TM
Briscoe
J
J
D000818:Animals; D002642:Chick Embryo; D004268:DNA-Binding Proteins / Q000096:biosynthesis / Q000502:physiology*; D004627:Embryonic Induction; D005136:Eye Proteins; D053823:Hedgehog Proteins; D000090322:Homeobox Protein Nkx-2.2; D018398:Homeodomain Proteins / Q000096:biosynthesis; D007395:Interneurons / Q000145:classification / Q000166:cytology / Q000502:physiology; D009046:Motor Neurons / Q000145:classification / Q000166:cytology / Q000502:physiology; D009420:Nervous System / Q000166:cytology / Q000196:embryology*; D009474:Neurons / Q000166:cytology / Q000502:physiology*; D009924:Organ Culture Techniques; D000071841:PAX6 Transcription Factor; D051761:Paired Box Transcription Factors; D011506:Proteins / Q000502:physiology*; D012097:Repressor Proteins; D012249:Rhombencephalon / Q000166:cytology / Q000196:embryology; D015398:Signal Transduction; D013116:Spinal Cord / Q000166:cytology / Q000196:embryology; D013234:Stem Cells / Q000166:cytology* / Q000502:physiology*; D015534:Trans-Activators; D014157:Transcription Factors / Q000096:biosynthesis / Q000502:physiology*; D029961:Zebrafish Proteins
D004268:DNA-Binding Proteins; D005136:Eye Proteins; D053823:Hedgehog Proteins; D000090322:Homeobox Protein Nkx-2.2; D018398:Homeodomain Proteins; D000071841:PAX6 Transcription Factor; D051761:Paired Box Transcription Factors; D011506:Proteins; D012097:Repressor Proteins; D015534:Trans-Activators; D014157:Transcription Factors; D029961:Zebrafish Proteins; C000715630:nkx2.2b protein, zebrafish