Long circulating superparamagnetic particles with high T2 relaxivity.
Novel superparamagnetic particles coated with a phospholipid and a surfactant were characterized and evaluated in vivo. These particles (SBPA) were shown to exhibit r2 relaxivities in the range of 350-450 mM-1.s-1, r1 values of 8-12 mM-1.s-1 and sizes of 50-80 nm. Preliminary results of pharmacokinetics were obtained in rats following the administration of 59Fe-labelled preparations. The particles were shown to remain for hours in the blood stream before being cleared mainly by the liver. Most of 59Fe was eliminated from the body and recovered in the feces within a week. These biodistribution and elimination properties deserve more detailed studies and suggest the potential use of this product as a blood pool contrast agent.
Pochon
S
S
Bracco Research SA, Geneva, Switzerland. pochon@bracco.ch
Hyacinthe
R
R
Terrettaz
J
J
Robert
F
F
Schneider
M
M
Tournier
H
H
D000818:Animals; D003287:Contrast Media / Q000493:pharmacokinetics; D005243:Feces / Q000737:chemistry; D052203:Ferrosoferric Oxide; D007501:Iron / Q000493:pharmacokinetics; D007504:Iron Radioisotopes; D008099:Liver / Q000378:metabolism; D008279:Magnetic Resonance Imaging / Q000295:instrumentation / Q000379:methods*; D010087:Oxides / Q000493:pharmacokinetics; D010316:Particle Size; D051381:Rats; D017207:Rats, Sprague-Dawley; D013154:Spleen / Q000378:metabolism; D013997:Time Factors; D014018:Tissue Distribution
D003287:Contrast Media; D007504:Iron Radioisotopes; D010087:Oxides; D007501:Iron; D052203:Ferrosoferric Oxide