title: Synthesis and antimycobacterial activity of nitroxanthones. 2nd communication: antimycobacterial activity.
abstract: The mono-, di-, tri- and tetranitroxanthones have been tested against different mycobacteria by means of the Agar diffusion method resulting in minimum inhibitory concentrations (MIC) and for more precise interpretation by means of the bacterial growth kinetics method. Nitroxanthones with the 2,4-dinitro-substitution pattern show activities beyond 1 microgram/ml.
authors.affiliation: Department of Pharmacy, Faculty of Chemistry, University of Freiburg, Germany.
authors.forename: W G
authors.initials: WG
authors.lastname: Ibrom
authors.forename: K J
authors.initials: KJ
authors.lastname: Schaper
authors.forename: A W
authors.initials: AW
authors.lastname: Frahm
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D015169:Colony Count, Microbial; D008826:Microbial Sensitivity Tests; D009161:Mycobacterium / Q000187:drug effects* / Q000254:growth & development; D009574:Nitro Compounds / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014966:Xanthenes / Q000494:pharmacology*; D044004:Xanthones
chemical_list: C107567:2,4,5,7-tetranitro-xanthone; C107566:2,4,7-trinitro-xanthone; C107565:2,4-dinitro-xanthone; D000900:Anti-Bacterial Agents; D009574:Nitro Compounds; D014966:Xanthenes; D044004:Xanthones