Urea removal by neonatal hemo(dia)filters in hyperazotemic rabbits.
OBJECTIVE
Comparison of three neonatal hemo(dia)filters (FH22, Gambro; Minifilter Plus, Amicon; Miniflow 10, Hospal) for removal of urea by venovenous hemofiltration (HF) and venovenous hemodiafiltration (HDF).


METHODS
Filters were successively used for HF with two different blood flows (Qb = 8.3 and 16.6 ml/ min) and for HDF with the two different blood flows and four dialysate flows (Qd = 0.5, 1.0, 2.0, and 3.0 l/h).


METHODS
21 anesthetized adult New Zealand White rabbits infused with urea.


RESULTS
Urea clearance was significantly increased by HDF compared to HF regardless of blood flow, dialysate flow, and the hemo (dia)filter type except in the FH22 group, when blood flow was high and dialysate flow was 0.5 or 1.0 l/h. The FH22 filter allowed the best urea clearance during HF at high blood flow. During the HDF procedures, the Miniflow 10 allowed the highest urea clearance regardless of blood flow and dialysate flow.
Gouyon
J B
JB
Laboratoire de Néphrologie-Hémaphérèse-Transplantation, Centre Hospitalier Universitaire, Dijon, France.
Françoise
M
M
Semama
D S
DS
Prévot
A
A
d'Athis
P
P
Lallemant
C
C
D000704:Analysis of Variance; D000818:Animals; D017583:Hemodiafiltration / Q000295:instrumentation*; D006440:Hemofiltration / Q000295:instrumentation*; D016014:Linear Models; D008297:Male; D011817:Rabbits; D014508:Urea / Q000097:blood*
D014508:Urea