title: [Detection of liver metastases from digestive cancer. Value of alkaline phosphatases, their macromolecular isoenzyme and of ceruloplasmin].
abstract: In order to improve the non aggressive diagnosis of hepatic metastasis from digestive neoplasm, the authors analyzed the following biological parameters: aminotransferases, alkaline phosphatase and lacticodehydrogenase isoenzymes, gammaglutamyl-transpeptidase, conjugated and total bilirubin, C-reactive protein, type A, G, M immunoglobulins, C3 complement factor, alpha-1 acidic glycoprotein (orosomucoid), haptoglobin, ceruloplasmin, transferrin, albumin, prealbumin, ferritin. This work included 54 patients with digestive tract cancer (esophageal, gastric, colic, rectal, anal localizations), divided in two groups: M- (n = 27), without hepatic metastasis), and M+ (n = 27, with histological confirmed hepatic metastasis). The Mann-Whitney test showed significant differences for 12 parameters between the 2 groups. With more than 60% sensitivity (Se) and specificity (Sp), according to the ROC curves, the following parameters can be selected: Total alkaline phosphatase (Se 89%, Sp 70%) and their macromolecular H2 fraction, lacticodehydrogenase fraction 4 (Se 63%, Sp 63%), gammaglutamyl-transpeptidase (Se 85%, Sp 82%), ceruloplasmin (Se 64%, Sp 65%), aspartate-aminotransferase determination (Se 63%, Sp 65%).
authors.affiliation: Service de médecine interne E, CHU Saint-Eloi, Montpellier, France.
authors.forename: M T
authors.initials: MT
authors.lastname: Piva
authors.forename: V
authors.initials: V
authors.lastname: Sieso
authors.forename: S
authors.initials: S
authors.lastname: Lumbroso
authors.forename: P
authors.initials: P
authors.lastname: Perney
authors.forename: H
authors.initials: H
authors.lastname: Mion
authors.lastname: Blanc
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000469:Alkaline Phosphatase / Q000097:blood*; D002570:Ceruloplasmin / Q000032:analysis*; D004067:Digestive System Neoplasms / Q000097:blood / Q000473:pathology*; D005260:Female; D006801:Humans; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000097:blood*; D008113:Liver Neoplasms / Q000097:blood / Q000556:secondary*; D008297:Male; D008875:Middle Aged; D012372:ROC Curve; D018709:Statistics, Nonparametric
chemical_list: D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase; D002570:Ceruloplasmin; D000469:Alkaline Phosphatase
vernacular_title: Détection de métastases hépatiques d'un cancer digestif--intérêt des phosphatases alcalines, de leur isoenzyme macromoléculaire et de la céruléoplasmine.