Cell-cell signalling: frog frizbees.
The recent discovery that Frizzled proteins are receptor for Wnts has been quickly followed by the identification of a secreted protein, Frzb, that is related to Frizzled, expressed by the Spemann organizer in frog embryos and can bind to and antagonize Wnt developmental signalling molecules.
Zorn
A M
AM
Wellcome/CRC Institute of Cancer and Developmental Biology, Cambridge, UK.
D000818:Animals; D002450:Cell Communication / Q000502:physiology; D029721:Drosophila Proteins; D051157:Frizzled Receptors; D006023:Glycoproteins / Q000502:physiology; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins / Q000502:physiology; D008954:Models, Biological; D011506:Proteins / Q000235:genetics / Q000502:physiology*; D043562:Receptors, G-Protein-Coupled; D015398:Signal Transduction / Q000502:physiology*; D014981:Xenopus / Q000196:embryology / Q000235:genetics / Q000502:physiology*; D000099274:Frizzled-Related Proteins
D029721:Drosophila Proteins; D051157:Frizzled Receptors; D006023:Glycoproteins; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins; D011506:Proteins; D043562:Receptors, G-Protein-Coupled; D000099274:Frizzled-Related Proteins; C058784:fz protein, Drosophila