title: Minocycline and ethylenediaminetetraacetate for the prevention of recurrent vascular catheter infections.
abstract: Three patients with recurrent vascular catheter-related bacteremia were successfully treated by allowing a solution of minocycline and ethylenediaminetetraacetate (EDTA) to dwell in the lumen of the indwelling catheter or by coating polyurethane catheters with minocycline/EDTA and flushing the lumen daily with the same solution. In vitro and in vivo experiments showed that minocycline/EDTA may have broad-spectrum antimicrobial activity, may have optimal anticoagulant activity, and may be highly efficacious in preventing catheter colonization.
authors.affiliation: Department of Medical Specialties, University of Texas M.D. Anderson Cancer Center, Houston 77030, USA.
authors.forename: I
authors.initials: I
authors.lastname: Raad
authors.forename: A
authors.initials: A
authors.lastname: Buzaid
authors.forename: J
authors.initials: J
authors.lastname: Rhyne
authors.forename: R
authors.initials: R
authors.lastname: Hachem
authors.forename: R
authors.initials: R
authors.lastname: Darouiche
authors.forename: H
authors.initials: H
authors.lastname: Safar
authors.forename: M
authors.initials: M
authors.lastname: Albitar
authors.forename: R J
authors.initials: RJ
authors.lastname: Sherertz
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D000925:Anticoagulants / Q000627:therapeutic use; D016470:Bacteremia / Q000209:etiology / Q000517:prevention & control*; D002405:Catheterization, Central Venous / Q000009:adverse effects*; D004359:Drug Therapy, Combination; D004492:Edetic Acid / Q000627:therapeutic use*; D004754:Enterobacter / Q000302:isolation & purification; D004756:Enterobacteriaceae Infections / Q000209:etiology / Q000517:prevention & control*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008911:Minocycline / Q000627:therapeutic use*; D012008:Recurrence; D013203:Staphylococcal Infections / Q000209:etiology / Q000517:prevention & control*
chemical_list: D000900:Anti-Bacterial Agents; D000925:Anticoagulants; D004492:Edetic Acid; D008911:Minocycline