title: [Forensic hematology genetics--paternity testing].
abstract: In Switzerland paternity investigations are carried out using DNA analysis only since 1991. DNA patterns are inherited and only with the exception of genetically identical twins they are different in everyone and therefore unique to an individual. Hence DNA-systems are an excellent tool to resolve paternity disputes. DNA polymorphisms used for paternity diagnosis are length polymorphisms of the highly polymorphic VNTR loci [variable number of tandem repeats]. The most frequently applied systems are the DNA single locus systems. In addition to the DNA single locus systems the application of PCR (PCR = polymerase chain reaction) based DNA systems has increased particularly in difficult deficiency cases or in cases where only small evidential samples or partially degraded DNA are available. Normally four independent DNA single probes are used to produce a DNA profile from the mother, the child and the alleged father. A child inherits half the DNA patterns from its mother and the other half from its true biological father. If an alleged father doesn't possess the paternal specific DNA pattern in his DNA profile he is excluded from the paternity. In case of non-exclusion the probability for paternity is calculated according to Essen-Möller. When applying four highly polymorphic DNA single locus systems the biostatistical evaluation leads always to W-values exceeding 99.8% [= required value for positive proof of paternity]. DNA analysis is currently the best available method to achieve such effective conclusions in paternity investigations.
authors.affiliation: Institut für Rechtsmedizin, Universität Zürich-Irchel, Zürich.
authors.forename: A
authors.initials: A
authors.lastname: Kratzer
authors.forename: W
authors.initials: W
authors.lastname: Bär
mesh_terms: D001789:Blood Group Antigens / Q000235:genetics*; D002648:Child; D016172:DNA Fingerprinting; D005260:Female; D006801:Humans; D007603:Jurisprudence; D008297:Male; D018598:Minisatellite Repeats; D010334:Paternity; D016133:Polymerase Chain Reaction; D013557:Switzerland
chemical_list: D001789:Blood Group Antigens
vernacular_title: Forensische Hämogenetik--Abstammungsbegutachtung.