Identification of four new DR52-associated DRB1 alleles: DRB1*1424, *1425, *1323 and *1324.
Four previously unreported DR52-associated DRB1 alleles have been characterized through DNA sequencing, contributing to the diversity of the HLA system. DRB1*1424 is nearly identical to DRB1*1402 in the second exon, except that it contains the "I---A" motif found at codons 67-71 common to the DRB1*15 alleles. DRB1*1425 contains the "A--H" motif, found in DRB1*1401 at codons 57-60, in a sequence otherwise identical with the second exon of DRB1*1307. Compared with DRB1*11012, DRB1*1323 contains three predicted amino acid changes at codons 58 (ala-->glu), 67 (phe-->ile), and 71 (arg-->glu). The sequence of DRB1*1324 is identical to exon 2 of DRB1*1103, except that DRB1*1324 does not contain the GAG at codon 58 characteristic of the DRB1*11 alleles. These new alleles may have arisen through gene conversion, and they contribute to the complexity of the DR6 family.
Ellis
J M
JM
Department of Microbiology and Immunology, Georgetown University Medical Center, Washington, District of Columbia, USA.
Robbins
F
F
Wang
J
J
Tang
T
T
Heine
U
U
Mason
J M
JM
Sese
D
D
Milford
E
E
Hurley
C K
CK
D000483:Alleles; D001483:Base Sequence; D004247:DNA; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006801:Humans; D008969:Molecular Sequence Data; D011110:Polymorphism, Genetic
D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; D004247:DNA