title: Dendritic signal integration.
abstract: Recent studies have identified various forms of active dendritic signals that may contribute to neuronal integration. One of the most remarkable findings is the demonstration of highly localized Ca2+ transients that are limited to small dendritic segments and even to single dendritic spines. In addition, through use of the powerful two-photon excitation imaging technique, it has been possible to reveal the existence of dendritic Ca2+ signals under in vivo conditions. Finally, active backpropagation of action potentials into dendrites has been shown to boost dendritic Ca2+ signals supralinearly and, thus, to contribute to the induction of long-term potentiation.
authors.affiliation: I. Physiologisches Institut, Universit-at des Saarlandes, 66421 Homburg, Germany. phjeil@med-rz.uni-sb.de
authors.forename: J
authors.initials: J
authors.lastname: Eilers
authors.forename: A
authors.initials: A
authors.lastname: Konnerth
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism; D003712:Dendrites / Q000502:physiology*; D009473:Neuronal Plasticity / Q000502:physiology; D011689:Purkinje Cells / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D002118:Calcium