Chromosome aberrations after radiotherapy in patients treated for non Hodgkin's lymphoma.
Chromosome aberrations were evaluated in the lymphocytes of 30 patients who had undergone radiotherapy several years before for non-Hodgkin's lymphoma. Twelve had received 20 Gy over the entire abdomen (group I), 12 wholebody irradiation at 1.5 Gy (group II) and 6 wholebody irradiation at 15 Gy (group III). Unirradiated patients seen for cytogenetic analysis during the same period served as controls. Overall results for the irradiated population were 13/27 (48%) evaluable patients with chromosome aberrations and 50/710 (7%) abnormal cells for a total of 73 aberrations (unstable: 35, stable: 38). The frequency of aberrations was statistically higher in group I (12% of cells) than in groups II (3.5%, p < 0.0001) and III (2.5%, p < 0.0002). Differences in irradiation dose and volume may account for the variations between groups.
Mahé
M A
MA
Service de Radiothérapie, Site Hospitalier Nord de Nantes, Saint-Herblain, France.
André
M J
MJ
Moyon
E
E
Le Mevel
A
A
Soubeyran
P
P
Hamidou
M
M
Milpied
N
N
Bourdin
S
S
Cuillière
J C
JC
Chatal
J F
JF
D016022:Case-Control Studies; D002869:Chromosome Aberrations; D006801:Humans; D008214:Lymphocytes / Q000528:radiation effects*; D008224:Lymphoma, Follicular / Q000235:genetics / Q000532:radiotherapy*; D011878:Radiotherapy / Q000009:adverse effects