RNA processing: pocket guides to ribosomal RNA.
The functional role of a recently identified class of small nucleolar (sno) RNAs has been elucidated: the 'box H/ACA' snoRNAs act as guide RNAs, specifying the position of evolutionarily conserved pseudouridines in ribosomal (r)RNA via an rRNA-snoRNA base-pairing interaction that forms a 'pseudouridine pocket'.
Peculis
B
B
Genetics and Biochemistry Branch, NIDDK, NIH, Bethesda, Maryland 20892, USA.
D001482:Base Composition; D001483:Base Sequence; D002466:Cell Nucleolus / Q000378:metabolism; D008954:Models, Biological; D011560:Pseudouridine / Q000737:chemistry / Q000378:metabolism; D012323:RNA Processing, Post-Transcriptional; D012335:RNA, Ribosomal / Q000737:chemistry / Q000378:metabolism*; D058727:RNA, Small Untranslated
D012335:RNA, Ribosomal; D011560:Pseudouridine; D058727:RNA, Small Untranslated