title: T-cell anergy induced by antigen presenting cells treated with the hemolysin of Listeria monocytogenes.
abstract: Antigen presenting cells (APC) that are infected with listeriolysin (LLO) secreting Listeria lack the ability to stimulate MHC class II restricted T-cells by conventional antigens. Similarly, T-cell activation by native proteins but not by peptides was inhibited upon pretreatment of APC with purified listeriolysin. The inhibition is due to an irreversible inactivation of T-cells that recognize antigen on infected or LLO treated APC. Inhibition was found to dominate over stimulation by peptides. This condition is reminiscent of T-cells inactivation by antagonistic peptides and represents a novel type of immune escape.
authors.affiliation: Division of Cell Biology and Immunology, National Research Centre for Biotechnology, Braunschweig, Germany. ada@gbf-braunschweig.de
authors.forename: A
authors.initials: A
authors.lastname: Darji
authors.forename: B
authors.initials: B
authors.lastname: Stockinger
authors.forename: J
authors.initials: J
authors.lastname: Wehland
authors.forename: T
authors.initials: T
authors.lastname: Chakraborty
authors.forename: S
authors.initials: S
authors.lastname: Weiss
mesh_terms: D000595:Amino Acid Sequence; D017951:Antigen Presentation; D000938:Antigen-Presenting Cells / Q000187:drug effects / Q000276:immunology* / Q000382:microbiology; D001427:Bacterial Toxins; D002460:Cell Line; D017635:Clonal Anergy; D006360:Heat-Shock Proteins / Q000494:pharmacology*; D006460:Hemolysin Proteins / Q000494:pharmacology*; D000949:Histocompatibility Antigens Class II / Q000276:immunology; D008089:Listeria monocytogenes; D008213:Lymphocyte Activation; D008969:Molecular Sequence Data; D010455:Peptides / Q000494:pharmacology; D013601:T-Lymphocytes / Q000276:immunology*; D014407:Tumor Cells, Cultured
chemical_list: D001427:Bacterial Toxins; D006360:Heat-Shock Proteins; D006460:Hemolysin Proteins; D000949:Histocompatibility Antigens Class II; D010455:Peptides; C038705:hlyA protein, Listeria monocytogenes