title: [Assessment of regional microcirculatory changes by EPI perfusion studies in patients with multiple lacunar infarction].
abstract: The aim of this report is to assess regional cerebral microcirculatory changes by EPI perfusion study in patients with multiple lacunar infarction(MLI). Especially, we focused on the parameter(rCBV, MTT, rCBF) changes in the white matter and on the relationship between these changes in the gray and white matter. Twenty MLI patients(mean age 72 +/- 15 years) and 10 age-similar normal controls (mean age 65 +/- 12 years) were examined. As a result, the MLI patients demonstrated an insignificant rCBF reduction due to the rCBV elevation in the gray matter and a moderate rCBF reduction with less rCBV elevation in the white matter. These results show a difference in the vascular reserve between the gray and white matter, and insufficiency of the vascular reserve in MLI's white matter.
authors.affiliation: Department of Radiology, Main Hospital, Nippon Medical School.
authors.forename: M
authors.initials: M
authors.lastname: Ishihara
authors.forename: Y
authors.initials: Y
authors.lastname: Amano
authors.forename: S
authors.initials: S
authors.lastname: Kumita
authors.forename: K
authors.initials: K
authors.lastname: Cho
authors.forename: S
authors.initials: S
authors.lastname: Mizumura
authors.forename: M
authors.initials: M
authors.lastname: Nakahara
authors.forename: S
authors.initials: S
authors.lastname: Okada
authors.forename: T
authors.initials: T
authors.lastname: Kumazaki
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001921:Brain / Q000098:blood supply*; D002544:Cerebral Infarction / Q000175:diagnosis / Q000503:physiopathology*; D017352:Echo-Planar Imaging; D005260:Female; D006801:Humans; D008297:Male; D008833:Microcirculation; D008875:Middle Aged; D012039:Regional Blood Flow