New indole derivatives with free radical scavenging activity from Agrocybe cylindracea.
Two new indole derivatives were isolated as free radical scavengers from the MeOH extract of Agrocybe cylindracea. The structures of these compounds were determined to be 6-hydroxy-1H-indole-3-carboxaldehyde (1) and 6-hydroxy-1H-indole-3-acetamide (2) on the basis of spectroscopic studies. Compounds 1 and 2 inhibited lipid peroxidation in rat liver microsomes, with IC50 values of 4.1 and 3.9 micrograms/mL, respectively.
Kim
W G
WG
Korea Research Institute of Bioscience and Biotechnology, KIST, Yusong, Taejon, Korea.
Lee
I K
IK
Kim
J P
JP
Ryoo
I J
IJ
Koshino
H
H
Yoo
I D
ID
D000818:Animals; D001487:Basidiomycota / Q000737:chemistry*; D016166:Free Radical Scavengers / Q000494:pharmacology*; D007211:Indoles / Q000737:chemistry* / Q000494:pharmacology; D015227:Lipid Peroxidation / Q000187:drug effects; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D013057:Spectrum Analysis
C107717:6-hydroxy-1H-indole-3-acetamide; C107718:6-hydroxy-1H-indole-3-carboxaldehyde; D016166:Free Radical Scavengers; D007211:Indoles