title: Inhibitory effect of dehydroevodiamine and evodiamine on nitric oxide production in cultured murine macrophages.
abstract: Possible antiinflammatory effects of dehydroevodiamine (1) and evodiamine (2) were examined by assessing their effects on NO production in the murine macrophage-like cell line RAW 264.7. The results indicated that both 1 and 2 inhibited the IFN-gamma/LPS-stimulated NO production in a concentration-dependent manner. However, 1 appeared to inhibit NO production by interfering not only with the priming signal initiated by IFN-gamma but also with iNOS protein synthesis, while 2 affected the former only.
authors.affiliation: National Research Institute of Chinese Medicine, Shih-Pai, Taipei, Taiwan, Republic of China.
authors.forename: W F
authors.initials: WF
authors.lastname: Chiou
authors.forename: Y J
authors.initials: YJ
authors.lastname: Sung
authors.forename: J F
authors.initials: JF
authors.lastname: Liao
authors.forename: A Y
authors.initials: AY
authors.lastname: Shum
authors.forename: C F
authors.initials: CF
authors.lastname: Chen
mesh_terms: D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D002478:Cells, Cultured; D007371:Interferon-gamma / Q000494:pharmacology; D008070:Lipopolysaccharides / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects* / Q000378:metabolism; D051379:Mice; D009569:Nitric Oxide / Q000096:biosynthesis*; D010936:Plant Extracts; D011799:Quinazolines / Q000494:pharmacology*
chemical_list: D000470:Alkaloids; D008070:Lipopolysaccharides; D010936:Plant Extracts; D011799:Quinazolines; D009569:Nitric Oxide; C028633:dehydroevodiamine; D007371:Interferon-gamma; C049639:evodiamine