title: Gas chromatographic/mass spectrometric determination of lysergic acid diethylamide (LSD) in serum samples.
abstract: A sensitive method for the detection and quantification of lysergic acid diethylamide (LSD) in serum samples is described. After liquid-liquid extraction the trimethylsilyl derivative of LSD is detected by gas chromatography-mass spectrometry. Experiments with spiked samples resulted in a recovery of 76%, the coefficient of variation was 9.3%. Excellent linearity was obtained over the range 0.1-10 ng ml-1. Additionally experiments demonstrating the light sensitivity of LSD are presented together with casuistics.
authors.affiliation: Institute of Legal Medicine, Rheinische Friedrich-Wilhelms-University, Bonn, Germany.
authors.forename: F
authors.initials: F
authors.lastname: Musshoff
authors.forename: T
authors.initials: T
authors.lastname: Daldrup
mesh_terms: D000293:Adolescent; D005554:Forensic Medicine / Q000379:methods; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods*; D006213:Hallucinogens / Q000097:blood* / Q000506:poisoning; D006801:Humans; D008238:Lysergic Acid Diethylamide / Q000097:blood* / Q000506:poisoning; D008297:Male; D012680:Sensitivity and Specificity
chemical_list: D006213:Hallucinogens; D008238:Lysergic Acid Diethylamide