Response of symptomatic myocardial ischemia in ischemic cardiomyopathy to intensive vasodilator therapy.
To determine the cardiovascular protective effects of angiotensin-converting enzyme inhibitors, we examined the response to intensive vasodilator therapy in patients with ischemic cardiomyopathy and ongoing angina pectoris. We found that for patients with ischemic cardiomyopathy and ongoing active angina, intensive vasodilator therapy with angiotensin-converting enzyme inhibition and nitrates improved not only heart failure-related symptoms, but also resulted in a significant improvement in symptomatic ischemia and ischemia-related morbid events.
Levine
T B
TB
Division of Cardiology, Henry Ford Hospital, Detroit, Michigan 48202, USA.
Levine
A B
AB
Vincenzi
A
A
Keteyian
S J
SJ
Billings
J
J
Lesch
M
M
D000787:Angina Pectoris / Q000150:complications / Q000188:drug therapy*; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use*; D004656:Enalapril / Q000627:therapeutic use*; D006333:Heart Failure / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D007548:Isosorbide Dinitrate / Q000627:therapeutic use*; D008875:Middle Aged; D012189:Retrospective Studies; D016896:Treatment Outcome; D014665:Vasodilator Agents / Q000627:therapeutic use*
D000806:Angiotensin-Converting Enzyme Inhibitors; D014665:Vasodilator Agents; D004656:Enalapril; D007548:Isosorbide Dinitrate