title: Syndrome of inappropriate ADH secretion attributed to the serotonin re-uptake inhibitors, venlafaxine and paroxetine.
abstract: We report on 2 patients with the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) which developed a few weeks after they had started treatment with venlafaxine and paroxetine, respectively. Due to the temporal relationship and the exclusion of other potential causes, a causal relationship between the use of the antidepressants and SIADH seems likely. Diagnostic criteria for SIADH and the role of drugs, especially serotonin re-uptake inhibitors, are discussed.
authors.affiliation: Department of Internal Medicine, Reinier de Graaf Gasthuis, Delft, Netherlands.
authors.forename: I A
authors.initials: IA
authors.lastname: Meynaar
authors.forename: A J
authors.initials: AJ
authors.lastname: Peeters
authors.forename: A H
authors.initials: AH
authors.lastname: Mulder
authors.forename: J P
authors.initials: JP
authors.lastname: Ottervanger
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003511:Cyclohexanols / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007177:Inappropriate ADH Syndrome / Q000139:chemically induced*; D008297:Male; D017374:Paroxetine / Q000009:adverse effects*; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects*; D000069470:Venlafaxine Hydrochloride
chemical_list: D003511:Cyclohexanols; D017374:Paroxetine; D017367:Selective Serotonin Reuptake Inhibitors; D000069470:Venlafaxine Hydrochloride