title: Ibogaine interferes with the establishment of amphetamine place preference learning.
abstract: The ability of ibogaine, injected 24 hr before amphetamine, to modify the establishment of amphetamine-induced place preference learning was assessed. A single injection of ibogaine blocked the establishment of amphetamine place preference after 1 or 2 conditioning trials, but it was less effective after 4 trials. The reduced effectiveness of ibogaine across multiple conditioning trials appears to be the result of the development of tolerance to ibogaine.
authors.affiliation: Department of Psychology, Wilfrid Laurier University, Waterloo, Ontario, Canada.
authors.forename: I
authors.initials: I
authors.lastname: Moroz
authors.forename: L A
authors.initials: LA
authors.lastname: Parker
authors.forename: S
authors.initials: S
authors.lastname: Siegel
mesh_terms: D000661:Amphetamine / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D000818:Animals; D000697:Central Nervous System Stimulants / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D003216:Conditioning, Operant / Q000187:drug effects*; D004361:Drug Tolerance; D007050:Ibogaine / Q000494:pharmacology*; D008297:Male; D011619:Psychotropic Drugs / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000697:Central Nervous System Stimulants; D011619:Psychotropic Drugs; D007050:Ibogaine; D000661:Amphetamine