[A method for preventing experimental pneumococcal infection].
Lethal pneumococcal infection in mice, infected intranasally, can be induced only by highly virulent strains of pneumococci. The introduction of N-acetylglucosamine and/or D-galactose, both 1 hour before the introduction of pneumococci or simultaneously with their introduction, prevented the development of this infection in 83-91% of mice used in the experiment. The use of the mixture of these carbohydrates did not change the level of their activity. These carbohydrates were shown to be capable of protecting mice from the intranasal introduction of 100-1000 LD50 of Streptococcus pneumoniae highly virulent strains, adapted to the respiratory tracts and lungs of mice.
Vishniakova
L A
LA
Reztsova
Iu V
IuV
D000117:Acetylglucosamine / Q000008:administration & dosage / Q000494:pharmacology; D000818:Animals; D004353:Drug Evaluation, Preclinical; D005690:Galactose / Q000008:administration & dosage / Q000494:pharmacology; D006801:Humans; D007928:Lethal Dose 50; D051379:Mice; D011008:Pneumococcal Infections / Q000382:microbiology / Q000517:prevention & control*; D012703:Serotyping; D013296:Streptococcus pneumoniae / Q000145:classification / Q000187:drug effects / Q000302:isolation & purification / Q000472:pathogenicity; D013997:Time Factors; D014774:Virulence / Q000187:drug effects
D000117:Acetylglucosamine; D005690:Galactose
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