Are choice and self-administration of marijuana related to delta 9-THC content?
The effects of delta 9-tetrahydrocannabinol (THC) content on choice marijuana, number of marijuana cigarettes smoked, and ratings of marijuana's effects were examined in 6 adult male marijuana smokers during a residential study consisting of four 3-day blocks of 2 sample days and 1 choice day. Days were divided into 6.5-hr work and social-access periods, beginning at 1000 and 1700. On sample days, marijuana cigarettes containing different THC concentrations (0.0% vs. 3.5% and 2.0% vs. 3.5% THC) were smoked at least once during each period. On choice days, independent choices between previously sampled marijuana cigarettes were made during each period. A maximum of 8 cigarettes could be smoked per day, and drug ratings were obtained after each period. Only choice behavior was sensitive to changes in THC content, whereas only the number of smoked marijuana cigarettes was related to context (i.e., work and social-access period).
Kelly
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TH
Department of Psychiatry, Johns Hopkins University School of Medicine, USA. thkelly@pop.uky.edu
Foltin
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Emurian
C S
CS
Fischman
M W
MW
D000328:Adult; D002188:Cannabis / Q000737:chemistry*; D013759:Dronabinol / Q000737:chemistry / Q000494:pharmacology*; D006213:Hallucinogens / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008385:Marijuana Smoking / Q000523:psychology*; D011680:Pupil / Q000187:drug effects; D012054:Reinforcement, Psychology; D012646:Self Administration; D012907:Smoking / Q000523:psychology
D006213:Hallucinogens; D013759:Dronabinol