Hormonal regulation of N-cadherin mRNA levels in rat granulosa cells.
We have examined the ability of hormones to modulate the steady-state levels of N-cadherin mRNA transcripts in aggregated and dispersed rat granulosa cell populations. Estradiol and follicle-stimulating hormone (FSH) had no effect on the levels of N-cadherin mRNA transcripts in aggregated granulosa cells. In contrast, these two hormones stimulated N-cadherin mRNA levels in dispersed granulosa cells. This is the first report that estradiol and FSH are capable of regulating N-cadherin mRNA levels. The results also suggest that the N-cadherin mRNA levels in dispersed and aggregated granulosa cells are regulated by different mechanisms.
Farookhi
R
R
Department of Physiology, McGill University, Montreal, Quebec, Canada.
Geng
C S
CS
MacCalman
C D
CD
Blaschuk
O W
OW
D000818:Animals; D001345:Autoradiography; D015152:Blotting, Northern; D015820:Cadherins / Q000235:genetics / Q000378:metabolism*; D005260:Female; D006107:Granulosa Cells / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism*; D051381:Rats
D015820:Cadherins; D012333:RNA, Messenger