5-HT1D and 5-HT1E/1F binding sites in depressed suicides: increased 5-HT1D binding in globus pallidus but not cortex.
5-HT1D and 5-HT1E/1F receptor binding sites were measured in brain samples obtained at postmortem from suicide victims with a firm retrospective diagnosis of depression, and matched controls. In antidepressant-free suicides a significantly higher number of 5-HT1D receptors was found in globus pallidus. This was largely restricted to those suicides who died by violent means. This effect was not observed in antidepressant-treated suicides. No differences or trends in 5-HT1D binding were found in putamen, parietal or frontal cortex, in antidepressant-free or antidepressant-treated suicides. There were no differences in the number of 5-HT1E/1F receptors in any of the regions studied.
Lowther
S
S
Department of Pharmacology and Clinical Phamacology, St George's Hospital Medical School, London, UK. slowther@sghms.ac.uk
Katona
C L
CL
Crompton
M R
MR
Horton
R W
RW
D000293:Adolescent; D000328:Adult; D000368:Aged; D000928:Antidepressive Agents / Q000008:administration & dosage; D001665:Binding Sites / Q000502:physiology; D003863:Depression / Q000188:drug therapy / Q000378:metabolism*; D005260:Female; D005625:Frontal Lobe / Q000737:chemistry / Q000378:metabolism*; D005917:Globus Pallidus / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010296:Parietal Lobe / Q000737:chemistry / Q000378:metabolism; D011699:Putamen / Q000737:chemistry / Q000378:metabolism; D044346:Receptor, Serotonin, 5-HT1D; D011985:Receptors, Serotonin / Q000032:analysis / Q000378:metabolism*; D012189:Retrospective Studies; D013405:Suicide; D000096642:Receptor, Serotonin, 5-HT1F
D000928:Antidepressive Agents; D044346:Receptor, Serotonin, 5-HT1D; D011985:Receptors, Serotonin; D000096642:Receptor, Serotonin, 5-HT1F