Platelet serotonin transporter in coeliac disease.
We investigated a peripheral serotonergic marker, i.e. platelet tritiated imipramine (3H-IMI) binding sites, which are part of the 5-HT transporter complex similar to that present in the brain, in 20 patients affected by coeliac disease (CD), as compared with 20 healthy controls. Platelet membranes and 3H-IMI binding were carried out according to a standardized protocol. The results showed that coeliac patients had significantly lower 3H-IMI binding sites than controls. This finding would suggest the presence of a dysfunction at the level of the 5-HT transporter that might underline the psychic disturbances frequently observed in coeliac patients.
Chiaravalloti
G
G
Institute of Paediatrics, University of Pisa, Italy.
Marazziti
D
D
Batistini
A
A
Favilli
T
T
Ughi
C
C
Ceccarelli
M
M
Cassano
G B
GB
D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D001665:Binding Sites; D015415:Biomarkers / Q000032:analysis; D001792:Blood Platelets / Q000378:metabolism*; D002352:Carrier Proteins / Q000378:metabolism*; D002446:Celiac Disease / Q000097:blood* / Q000503:physiopathology; D002648:Child; D002675:Child, Preschool; D005260:Female; D006023:Glycoproteins / Q000378:metabolism*; D006801:Humans; D007099:Imipramine / Q000097:blood / Q000378:metabolism; D008297:Male; D012701:Serotonin / Q000097:blood / Q000378:metabolism*; D050486:Serotonin Plasma Membrane Transport Proteins; D012737:Sex Factors; D013156:Splenectomy
D015415:Biomarkers; D002352:Carrier Proteins; D006023:Glycoproteins; D050486:Serotonin Plasma Membrane Transport Proteins; D012701:Serotonin; D007099:Imipramine