title: Biological role of carbamoyl pyridoxal 5'-phosphate.
abstract: A new compound, carbamoyl-pyridoxal 5'-phosphate (C-PLP), was synthetized by condensation of pyridoxal 5'-phosphate (PLP) with KCNO. It may be obtained under certain physiological conditions of pH, temperature and concentration of reagents. Formation and degradation of C-PLP are readily reversible chemical reactions, not involving enzymes, at least in rat tissues. However, different considerations suggest that synthesis and breakdown of C-PLP play a biological role in the cell, providing 'protective synthesis' and a 'variable reservoir' of PLP and KCNO, which can be trapped by other proteins, apoenzymes and metabolites, to regulate many cell metabolic functions.
authors.affiliation: Istituto di Biochimica e di Enzimologia, Facolta di Medicina e Chirurgia, Universita de Siena, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Terzuoli
authors.forename: M
authors.initials: M
authors.lastname: Pizzichini
authors.forename: R
authors.initials: R
authors.lastname: Pagani
authors.forename: R
authors.initials: R
authors.lastname: Guerranti
authors.forename: F
authors.initials: F
authors.lastname: Ponticelli
authors.forename: R
authors.initials: R
authors.lastname: Leoncini
authors.forename: E
authors.initials: E
authors.lastname: Marinello
mesh_terms: D000818:Animals; D001831:Body Temperature; D002221:Carbamyl Phosphate / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D008099:Liver / Q000378:metabolism; D008297:Male; D011732:Pyridoxal Phosphate / Q000031:analogs & derivatives* / Q000096:biosynthesis / Q000138:chemical synthesis / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
chemical_list: D002221:Carbamyl Phosphate; D011732:Pyridoxal Phosphate