title: Acanthosis nigricans associated with hepatolenticular degeneration.
abstract: Acanthosis nigricans and hepatolenticular degeneration (Wilson's disease) developed simultaneously in a 16-year-old boy. The diagnosis of Wilson's disease was based on the clinical presentation, including Kayser-Fleischer ring, hypoceruloplasminemia, hypocupremia, and hypercupriuria. His skin lesions were characterized by thick, dark brown, verrucous plaques on the dorsa of both feet, the neck, axillae, and groin. The histological findings were compatible with acanthosis nigricans. Six months after treatment with D-penicillamine, two grams per day, his skin lesions and neurological symptoms were much improved and no complications were observed.
authors.affiliation: Department of Medicine, Rajavithi General Hospital, Bangkok, Thailand.
authors.forename: Y
authors.initials: Y
authors.lastname: Thaipisuttikul
mesh_terms: D000052:Acanthosis Nigricans / Q000150:complications* / Q000473:pathology; D000293:Adolescent; D006527:Hepatolenticular Degeneration / Q000150:complications*; D006801:Humans; D008297:Male; D012867:Skin / Q000473:pathology