[Myopathy caused by inhibitors of hydroxymethylglutaryl-coenzyme A reductase].
BACKGROUND
Hydroxymethylglutaryl-Coenzyme A (HMG-CoA) Reductase inhibitors are a group of drugs widely used for hypercholesterolemia. They are known to originate side-effects on muscles but with a very low incidence of myopathy.


METHODS
We present two cases of myopathy induced by HMG-CoA reductase inhibitors. They are two women, who were on 20 mg daily of lovastatin and 30 mg daily of simvastatin and consulted due to weakness, myalgia and a rise in blood levels of muscle enzymes. Both of them recovered completely a few weeks after withdrawal of the drugs.


CONCLUSIONS
Usage of this group of drugs is wide. Their side effects are rare but it is important to remember their capacity to induce a myopathy, usually reversible upon withdrawal of the drug.
Martinez-García
F A
FA
Servicio de Neurologia, Hospital Universitario Virgen de la Arrixaca, Murcia, Espana.
Martín-Fernández
J
J
Moltó
J M
JM
Villaverde
R
R
Morales
A
A
Fernández-Barreiro
A
A
D004576:Electromyography; D004791:Enzyme Inhibitors / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000009:adverse effects*; D008148:Lovastatin / Q000008:administration & dosage / Q000009:adverse effects* / Q000031:analogs & derivatives*; D008875:Middle Aged; D017240:Mitochondrial Myopathies / Q000139:chemically induced* / Q000175:diagnosis; D019821:Simvastatin
D004791:Enzyme Inhibitors; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D008148:Lovastatin; D019821:Simvastatin
Miopatía producida por inhibidores de la hidroxi-metilglutaril-coenzima A reductasa.