Indole alkaloids from Sickingia williamsii reduce the in-vitro effects of morphine withdrawal in the guinea-pig.
The effect of indole alkaloids from Sickingia williamsii Standl. (Rubiaceae) on the effects of morphine withdrawal have been examined in-vitro. All the indole alkaloids isolated from S. williamsii (10(-4), 5 x 10(-5) and 10(-5) M) significantly and in a concentration-dependent manner reduced the effects of morphine withdrawal on the guinea-pig ileum. The results suggest that these alkaloids might be potential anti-addictive agents.
Capasso
A
A
Department of Pharmaceutical Sciences, University of Salerno, Italy.
Aquino
R
R
Garofalo
L
L
De Simone
F
F
Sorrentino
L
L
D000109:Acetylcholine / Q000008:administration & dosage / Q000494:pharmacology; D000470:Alkaloids / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004558:Electric Stimulation; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects* / Q000473:pathology; D007211:Indoles / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D009020:Morphine / Q000009:adverse effects*; D009021:Morphine Dependence / Q000188:drug therapy; D009270:Naloxone / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D009292:Narcotic Antagonists / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D009294:Narcotics / Q000009:adverse effects*; D019666:Rubiaceae; D013375:Substance Withdrawal Syndrome / Q000188:drug therapy*
D000470:Alkaloids; D007211:Indoles; D009292:Narcotic Antagonists; D009294:Narcotics; D009270:Naloxone; D009020:Morphine; D000109:Acetylcholine