CP2289, a new 5-HT3 receptor ligand: agonistic activities on gastroenteric motility.
A new 5-HT3 receptor ligand, CP2289, was synthesized and pharmacologically tested. Although CP2289 inhibited the Bezold-Jarisch reflex, it contracted the excised ileal muscle of mice, rats and guinea pigs. This response may reflect a partial agonist character of CP2289 in the gut. In vivo antiemetic and gastric emptying tests gave similar results.
Sato
Y
Y
Pharmaceutical Research Center, Meiji Seika Kaisha, Yokohama, Japan.
Imai
M
M
Amano
K
K
Iwamatsu
K
K
Konno
F
F
Kurata
Y
Y
Sakakibara
S
S
Hachisu
M
M
Izumi
M
M
Matsuki
N
N
Saito
H
H
D000818:Animals; D000932:Antiemetics / Q000494:pharmacology; D001583:Benzoxazoles / Q000494:pharmacology*; D002945:Cisplatin / Q000009:adverse effects; D005260:Female; D005746:Gastric Emptying / Q000187:drug effects; D005769:Gastrointestinal Motility / Q000187:drug effects*; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects / Q000502:physiology; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D010879:Piperazines / Q000494:pharmacology*; D051381:Rats; D011985:Receptors, Serotonin / Q000187:drug effects*; D044406:Receptors, Serotonin, 5-HT3; D017366:Serotonin Receptor Agonists / Q000494:pharmacology*; D012788:Shrews; D014839:Vomiting / Q000139:chemically induced / Q000517:prevention & control
D000932:Antiemetics; D001583:Benzoxazoles; C108245:CP 2289; D010879:Piperazines; D011985:Receptors, Serotonin; D044406:Receptors, Serotonin, 5-HT3; D017366:Serotonin Receptor Agonists; D002945:Cisplatin