The InsP3 receptor and intracellular Ca2+ signaling.
The inositol 1,4,5-trisphosphate receptor (InsP3R) is a ligand-gated Ca2+-release channel on intracellular Ca2+ store sites (such as the endoplasmic reticulum), and plays an important role in intracellular Ca2+ signaling in a wide variety of cell types. Recent studies have shown that binding of inositol 1,4,5-trisphosphate (InsP3) to InsP3R isoforms is differentially regulated by Ca2+, and that InsP3R functions are finely regulated by phosphorylation via tyrosine kinases and protein kinase C, by dephosphorylation via calcineurin, and by binding to FKBP (FK506-binding protein). In addition, transient receptor potential (TRP) and TRP-like proteins appear to couple conformationally with the InsP3R for capacitative Ca2+ entry. The importance of InsP3R signaling in neuronal function has been demonstrated by gene targeting in mice and by studies of T-cell receptor signaling, apoptosis, meiotic maturation, and cytokinesis.
Mikoshiba
K
K
Department of Molecular Neurobiology, Institute of Medical Science University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo, 108, Japan.
D000818:Animals; D001665:Binding Sites / Q000187:drug effects; D002118:Calcium / Q000502:physiology*; D015544:Inositol 1,4,5-Trisphosphate / Q000494:pharmacology / Q000502:physiology*; D051379:Mice; D015398:Signal Transduction / Q000502:physiology*
D015544:Inositol 1,4,5-Trisphosphate; D002118:Calcium