title: Alternatamides A-D: new bromotryptamine peptide antibiotics from the Atlantic marine bryozoan Amathia alternata.
abstract: Four new bromotryptamine peptides, alternatamides A-D (1-4), have been isolated from the Atlantic bryozoan Amathia alternata. The structures of the alternatamides were assigned primarily on the basis of 2D NMR data. The absolute stereochemistry of the N-methylleucine amino acid was shown to be L (2'S) by hydrolysis and comparison with standards. The alternatamides show modest antibacterial activities against several Gram-positive bacteria.
authors.affiliation: Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California at San Diego, La Jolla 92093-0236, USA.
authors.forename: N K
authors.initials: NK
authors.lastname: Lee
authors.forename: W
authors.initials: W
authors.lastname: Fenical
authors.forename: N
authors.initials: N
authors.lastname: Lindquist
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D007448:Invertebrates / Q000737:chemistry*; D008386:Marine Biology; D010455:Peptides; D013057:Spectrum Analysis; D013237:Stereoisomerism
chemical_list: D000900:Anti-Bacterial Agents; D010455:Peptides