[The efficacy of inhaled glucocorticosteroids in different dosage regimens and in combination with theophylline preparations in bronchial asthma patients].
The authors compare basic body plethysmography and peak flowmetry parameters, quality of life in 37 patients suffering from moderate or severe bronchial asthma. They received for 8 months low-dose glucocorticosteroids (group 1), high-dose glucocorticosteroids (group 2) and combination of low-dose glucocorticosteroids with long-acting theophyllin drugs (group 3). All the parameters assessed, quality of life was better in groups 2 and 3 (p < 0.05). Patients from these groups had also less frequent exacerbations of the disease which appeared less severe. From group 3 patients those who suffered longer and had marked emphysema showed a greater response.
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Gafurov
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D000280:Administration, Inhalation; D000328:Adult; D018927:Anti-Asthmatic Agents / Q000008:administration & dosage* / Q000009:adverse effects; D001249:Asthma / Q000188:drug therapy*; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage* / Q000009:adverse effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D011788:Quality of Life; D013806:Theophylline / Q000008:administration & dosage* / Q000009:adverse effects; D013997:Time Factors
D018927:Anti-Asthmatic Agents; D005938:Glucocorticoids; D013806:Theophylline
Effektivnost' ingaliatsionnykh gliukokortikosteroidov pri razlichnom rezhime dozirovaniia i v kombinatsii s preparatami teofillina u bol'nykh bronkhial'noĭ astmoĭ.