Coordinate reduction in cell proliferation and cell death in mouse olfactory epithelium from birth to maturity.
We investigated cell proliferation and cell death in the olfactory epithelium (OE) of mice from birth to maturity using bromodeoxyuridine and terminal deoxynucleotidyl transferase nick end labeling. We show that cell death events and proliferative activity diminish concomitantly with age in the OE. Thus, the age-dependent and coordinate diminution in cell proliferative activity and cell death events may serve to maintain the thickness of the OE as mice mature and age.
Fung
K M
KM
The Department of Pathology, New York University Medical Center, New York, USA.
Peringa
J
J
Venkatachalam
S
S
Lee
V M
VM
Trojanowski
J Q
JQ
D000375:Aging / Q000502:physiology*; D000818:Animals; D001710:Biotin; D002452:Cell Count; D016923:Cell Death / Q000502:physiology; D002455:Cell Division / Q000502:physiology; D053938:DNA Fragmentation; D003856:Deoxyuracil Nucleotides; D004847:Epithelial Cells; D051379:Mice; D008815:Mice, Inbred Strains; D009830:Olfactory Bulb / Q000166:cytology; D018034:Olfactory Receptor Neurons / Q000166:cytology*; D013194:Staining and Labeling
D003856:Deoxyuracil Nucleotides; D001710:Biotin