Synthesis and antimycobacterial activity of some new 3-heterocyclic substituted chromones.
The aldol synthesis of benzimidazole, benzothiazole and benzothiazolium salt derivatives of chromones is described. The structures of the compounds have been proved by elemental analysis and 1H NMR spectra. The antimycobacterial activity of some of the prepared compounds have been tested in vitro against Mycobacterium tuberculosis (H37Rv) and Mycobacterium fortuitum (1021).
Gasparová
R
R
Department of Organic Chemistry, Faculty of Natural Sciences, Comenius University, Bratislava, Slovakia.
Lácová
M
M
el-Shaaer
H M
HM
Odlerová
Z
Z
D000995:Antitubercular Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D001562:Benzimidazoles / Q000138:chemical synthesis / Q000494:pharmacology; D052160:Benzothiazoles; D002867:Chromones / Q000138:chemical synthesis / Q000494:pharmacology*; D006571:Heterocyclic Compounds / Q000138:chemical synthesis / Q000494:pharmacology*; D009161:Mycobacterium / Q000187:drug effects; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D013844:Thiazoles / Q000138:chemical synthesis / Q000494:pharmacology
D000995:Antitubercular Agents; D001562:Benzimidazoles; D052160:Benzothiazoles; D002867:Chromones; D006571:Heterocyclic Compounds; D013844:Thiazoles; C005465:benzothiazole