Acute myeloblastic leukemia associated with trisomy 8 and translocation 8;21 in a child with Down syndrome.
The present study examined an 11-year-old girl with Down syndrome who suffered from acute myeloblastic leukemia (AML) preceded by preleukemic pancytopenia. Chromosomal analysis of leukemic cells revealed a chromosome change at t(8;21) and trisomy 8 associated with constitutional trisomy 21. Treatment with antineoplastic agents led to complete remission.
Yamaguchi
Y
Y
Second Department of Pediatrics, Ohashi Hospital Toho University School of Medicine, Tokyo, Japan.
Fujii
H
H
Kazama
H
H
Iinuma
K
K
Shinomiya
N
N
Aoki
T
T
D002648:Child; D002871:Chromosome Banding; D002891:Chromosomes, Human, Pair 21; D002898:Chromosomes, Human, Pair 8; D004314:Down Syndrome / Q000150:complications* / Q000235:genetics; D005260:Female; D006801:Humans; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000150:complications / Q000235:genetics*; D010198:Pancytopenia / Q000150:complications; D014178:Translocation, Genetic; D014314:Trisomy