title: Potentiometric and coulometric titration of 6-propyl-2-thiouracil.
abstract: A method for the determination of 6-propyl-2-thiouracil involving its reaction with iodine in an alkaline medium is presented. In volumetric titration with potentiometric end-point detection, the range of determination is 125-500 mumol (21-85 mg). In coulometric titration using biamperometric end-point detection, 0.5-5.0 mumol (0.085-0.85 mg) of 6-propyl-2-thiouracil was successfully determined. The RSD in all applied techniques was < 1%. The methods developed were applied to the determination of 6-propyl-2-thiouracil in tablets.
authors.affiliation: Department of Instrumental Analysis, University of Lodź, Poland.
authors.forename: W
authors.initials: W
authors.lastname: Ciesielski
authors.forename: R
authors.initials: R
authors.lastname: Zakrzewski
mesh_terms: D013956:Antithyroid Agents / Q000032:analysis*; D004572:Electrolysis; D011199:Potentiometry / Q000379:methods; D011441:Propylthiouracil / Q000032:analysis*; D013607:Tablets
chemical_list: D013956:Antithyroid Agents; D013607:Tablets; D011441:Propylthiouracil