title: Efficacy and safety of mebendazole in children with worm infestation.
abstract: Children aged between 2-16 years, were screened for worm infestation. Fifty-five children fulfilling the inclusion criteria were included in the study. They were treated with mebendazole 100 mg twice daily for three consecutive days and followed-up for 15 days to assess cure rate and side effects. Fifty children completed the study with their stools being tested by direct smear and concentration methods and blood CBC done before treatment and at the end of the study. The cure rate for ascaris was 100% and for trichuris 75%. The drug was well tolerated and apart from mild diarrhoea occurring in 22% children, no untoward effects were reported. Nemazole (mebendazole) has shown promise and seems useful in treating children with worm infestation.
authors.affiliation: Department of Paediatrics, Dow Medical College, Karachi.
authors.forename: S
authors.initials: S
authors.lastname: Rafi
authors.forename: A
authors.initials: A
authors.lastname: Memon
authors.forename: A G
authors.initials: AG
authors.lastname: Billo
mesh_terms: D000293:Adolescent; D000818:Animals; D000969:Antinematodal Agents / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D003906:Developing Countries; D004334:Drug Administration Schedule; D005260:Female; D006373:Helminthiasis / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D008297:Male; D008463:Mebendazole / Q000627:therapeutic use*; D010154:Pakistan; D016896:Treatment Outcome
chemical_list: D000969:Antinematodal Agents; D008463:Mebendazole