Circulating endothelin-1 in obstructive sleep apnea.
Endothelin (ET)-1 is a potent vasoconstrictive and mitogenic peptide produced by endothelial cells and degraded predominantly in pulmonary vasculature. We measured ET-1 in 9-normotensive and 14 hypertensive men with obstructive sleep apnea. The ET-1 levels were higher in both normotensive (mean +/- SD, 6.3 +/- 2.8 pg/ml) and hypertensive (7.8 +/- 3.0 pg/ml) groups than in 66 healthy controls (2.9 +/- 1.2 pg/ml). Ten patients were restudied after three months of nCPAP treatment. No decrease in ET-1 was observed.
Saarelainen
S
S
Department of Pulmonary Diseases, Tampere University Hospital, Pikonlinna, Finland.
Seppälä
E
E
Laasonen
K
K
Hasan
J
J
D000328:Adult; D000402:Airway Obstruction / Q000097:blood* / Q000150:complications / Q000628:therapy; D019332:Endothelin-1 / Q000097:blood* / Q000378:metabolism; D004730:Endothelium, Vascular / Q000378:metabolism*; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000150:complications; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications; D017286:Polysomnography; D011175:Positive-Pressure Respiration; D012891:Sleep Apnea Syndromes / Q000097:blood* / Q000150:complications / Q000628:therapy
D019332:Endothelin-1