title: Effects of some anxiogenic agents on rat brain monoamine oxidase (MAO) A and B inhibitory (tribulin) activity.
abstract: Anxiogenic agents, yohimbine, pentylenetetrazole (PTZ), quinine, bufotenine, flumazenil and isatin were administered (ip) to rats at doses known to induce anxiety in this species. All the drugs exhibited anxiogenic response on the elevated plus-maze and induced a parallel increase in endogenous brain monoamine oxidase (MAO) inhibitory (tribulin) activity. The intensity of the drug-induced anxiety was fairly well correlated with the magnitude of increase in the MAO A inhibitory component of tribulin but not so with its MAO B inhibitory component. Thus, in the doses used, the degree of anxiogenic activity was PTZ > yohimbine > bufotenine > quinine > isatin > flumazenil, in terms of % entries on the open arms of the maze, whereas the magnitude of endogenous MAO A inhibition was PTZ > yohimbine > bufotenine > quinine > flumazenil > isatin. The results indicate that the MAO A inhibitory component of tribulin, rather than its MAO B inhibitory component, may be responsible for the postulated function of tribulin as an endogenous marker of anxiety.
authors.affiliation: Department of Pharmacology, Banaras Hindu University, Varanasi, India.
authors.forename: S K
authors.initials: SK
authors.lastname: Bhattacharya
authors.forename: A
authors.initials: A
authors.lastname: Chakrabarti
authors.forename: M
authors.initials: M
authors.lastname: Sandler
authors.forename: V
authors.initials: V
authors.lastname: Glover
mesh_terms: D000818:Animals; D001007:Anxiety / Q000139:chemically induced*; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D007510:Isatin; D008297:Male; D008995:Monoamine Oxidase / Q000378:metabolism*; D008996:Monoamine Oxidase Inhibitors / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D008996:Monoamine Oxidase Inhibitors; D007510:Isatin; C039776:tribulin; D008995:Monoamine Oxidase