title: Synthesis and pharmacological activity of 2-(substituted phenyl)-3-[2 or 3-[(4-substituted phenyl-4-hydroxy)piperidino]ethyl or propyl]-1,3-thiazolidin-4-ones.
abstract: A series of aryl-hydroxy-piperidinoalkyl-thiazolidinones was synthesized and evaluated to inhibit castor oil-induced diarrhea in mice. The dose dependent antidiarrheal activity of the most active compound 2-(p-nitrophenyl)-3-¿2-[(4-(p-chlorophenyl)-4-hydroxy)piperidino]ethyl]- 1, 3-thiazolidin-4-one (6) was counteracted by naloxone, resulting comparable with that of loperamide, a mu opiate agonist.
authors.affiliation: Dipartimento di Chimica Farmaceutica e Tossicologica, Università di Napoli, Federico II, Italia.
authors.forename: M V
authors.initials: MV
authors.lastname: Diurno
authors.forename: O
authors.initials: O
authors.lastname: Mazzoni
authors.forename: F
authors.initials: F
authors.lastname: Capasso
authors.forename: A A
authors.initials: AA
authors.lastname: Izzo
authors.forename: A
authors.initials: A
authors.lastname: Bolognese
mesh_terms: D000818:Animals; D000930:Antidiarrheals / Q000138:chemical synthesis / Q000494:pharmacology*; D008297:Male; D051379:Mice; D015394:Molecular Structure; D010880:Piperidines / Q000138:chemical synthesis / Q000494:pharmacology*; D013844:Thiazoles / Q000138:chemical synthesis / Q000494:pharmacology*
chemical_list: D000930:Antidiarrheals; D010880:Piperidines; D013844:Thiazoles