title: Divergent selection for heat loss in mice: I. Selection applied and direct response through fifteen generations.
abstract: Divergent selection for heat production/loss (kcal.kg-.75.d-1), measured in 9- to 11-wk-old male mice, was conducted for 15 generations. Heat loss was measured for 15 h on individual animals placed overnight in direct, gradient-layer calorimeters. Selection for high (MH) and low (ML) heat loss and unselected control (MC) occurred in each of three replicates for a total of nine unique lines. Repeatability of the heat loss measurement was .45 and the CV was 10.5%. Cumulative realized selection differentials, averaged for the three replicates, were 145.1 and -105.0 (kcal.kg-.75.d-1) and ranged from 136.9 to 149.2 and -17.1 to -101.3 for MH and ML selection, respectively. Cumulative standardized realized selection differentials, averaged for the three replicates, were 10.06 and -9.51 for MH and ML selection, respectively. Direct responses (kcal.kg-.75.d-1) in heat loss after 15 generations were 44.2 for MH and -27.4 for ML as deviations from MC. Asymmetry of response was evident (P = .03) by Generation 10. Realized heritability was .28 +/- .01 based on divergence of MH and ML selection. For selection for higher and lower heat loss, realized heritabilities were .31 +/- .01 and .26 +/- .01, respectively.
authors.affiliation: Department of Animal Science, University of Nebraska-Lincoln 68583-0908, USA.
authors.forename: M K
authors.initials: MK
authors.lastname: Nielsen
authors.forename: L D
authors.initials: LD
authors.lastname: Jones
authors.forename: B A
authors.initials: BA
authors.lastname: Freking
authors.forename: J A
authors.initials: JA
authors.lastname: DeShazer
mesh_terms: D000818:Animals; D001833:Body Temperature Regulation / Q000235:genetics / Q000502:physiology*; D001947:Breeding; D002151:Calorimetry / Q000379:methods / Q000662:veterinary; D004734:Energy Metabolism / Q000502:physiology*; D005260:Female; D008297:Male; D051379:Mice / Q000235:genetics / Q000502:physiology*; D008954:Models, Biological; D008957:Models, Genetic; D012044:Regression Analysis; D015203:Reproducibility of Results; D012641:Selection, Genetic