The effect of dietary selenium on lead neurotoxicity.
Lead, when administered to male rats for 8 weeks in a dose of 20 mg/kg body weight, resulted in the impairment of the enzymes hexokinase and total ATPase in the cerebral and cerebellar regions of the brain. The changes were, however, more pronounced in the cerebellar region. Along with these, a decrease in acetylcholine esterase (AchE) and monoamine oxidase (MAO) was seen, thus affecting both cholinergic and adrenergic neurotransmitters. When selenium was administered concomitantly with lead, the values of total ATPase and hexokinase activities approached normal values in both brain regions. A significant improvement in acetylcholine esterase activity and MAO was also seen.
Nehru
B
B
Department of Biophysics, Panjab University, Chandigarh, India.
Dua
R
R
D000110:Acetylcholinesterase / Q000187:drug effects; D000251:Adenosine Triphosphatases / Q000187:drug effects; D000284:Administration, Oral; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000201:enzymology; D002531:Cerebellum / Q000187:drug effects / Q000201:enzymology; D004032:Diet; D006593:Hexokinase / Q000187:drug effects; D007441:Intubation, Gastrointestinal; D007854:Lead / Q000008:administration & dosage / Q000633:toxicity*; D008297:Male; D008995:Monoamine Oxidase / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D012643:Selenium / Q000008:administration & dosage* / Q000494:pharmacology*
D007854:Lead; D008995:Monoamine Oxidase; D006593:Hexokinase; D000110:Acetylcholinesterase; D000251:Adenosine Triphosphatases; D012643:Selenium