[The combined effect of ionizing radiation and benzene on immunoreactivity indices in the spleen and lymph nodes].
Under the influence of the combined action of gamma irradiation (1 Gy, 1,15 Gy/min) and benzene the synergistic reduction of proportion and absolute content of B-cells and less expressed reduction of absolute content T-cells in spleen and lymph nodes was observed. In spleen the thymus-dependent humoral immune response was resistant to combined effect of irradiation and benzene, while in lymph nodes it was highly sensitive. The profound suppression of antibody formation in lymph nodes was characterized by synergism. It was accompanied by the block of specific recruitment of antigen sensitive cells within drained lymph nodes from migrating stream. The suppression of local immune response resulting from the combined effect of radiation and toxicants may be the cause of protective immunity disturbance.
Sharetskiĭ
A N
AN
Abramova
M R
MR
Zamulaeva
I A
IA
Kulish
Iu S
IuS
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects / Q000528:radiation effects; D000921:Antibody-Producing Cells / Q000187:drug effects / Q000276:immunology / Q000528:radiation effects; D000938:Antigen-Presenting Cells / Q000187:drug effects / Q000276:immunology / Q000528:radiation effects; D001554:Benzene / Q000494:pharmacology*; D005720:Gamma Rays; D007111:Immunity, Cellular / Q000187:drug effects / Q000528:radiation effects; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D008198:Lymph Nodes / Q000187:drug effects* / Q000276:immunology / Q000528:radiation effects*; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D013154:Spleen / Q000187:drug effects* / Q000276:immunology / Q000528:radiation effects*; D014916:Whole-Body Irradiation
D007166:Immunosuppressive Agents; D001554:Benzene
Sochetannyĭ éffekt ioniziruiushchego izlucheniia i benzola na nekotorye pokazateli immunoreaktivnosti v selezenke i limfaticheskikh uzlakh.