Biological and chemical study of paico (Chenopodium chilense, Chenopodiaceae).
The methanolic extract of the aerial portion of Chenopodium chilense Schrad., used in Chilean traditional medicine as a remedy for stomach-ache, has been found to exert the major spasmolytic activity in acetylcholine contracted rat ileum. This extract, with a complex flavonoid patterns on thin layer chromatography (TLC) analysis, is practically non-toxic both for rats and brine shrimp Artemia salina in acute toxicity test.
García
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R
Facultad de Ciencias Quimicas y Farmacéuticas, Departamento de Química Farmacológica y Toxicologica, Universidad de Chile, Santiago.
Lemus
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Rivera
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Erazo
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S
D000109:Acetylcholine / Q000037:antagonists & inhibitors; D000818:Animals; D019663:Chenopodiaceae / Q000737:chemistry*; D033364:Decapoda; D007082:Ileum / Q000187:drug effects* / Q000502:physiology; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects; D010276:Parasympatholytics / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats
D010276:Parasympatholytics; D000109:Acetylcholine