title: Resolution of invasive central nervous system aspergillosis in a transplant recipient.
abstract: Central nervous system (CNS) aspergillosis carries a uniformly poor prognosis in bone marrow transplant recipients. Amphotericin B can be bound to lipid carriers leading to improvement of its therapeutic index. We describe the successful medical management of CNS aspergillosis in an allogeneic bone marrow transplant patient with administration of Amphotericin B Lipid Complex.
authors.affiliation: Washington University School of Medicine, Department of Internal Medicine, St Louis, MO 63110-1093, USA.
authors.forename: H
authors.initials: H
authors.lastname: Khoury
authors.forename: D
authors.initials: D
authors.lastname: Adkins
authors.forename: G
authors.initials: G
authors.lastname: Miller
authors.forename: L
authors.initials: L
authors.lastname: Goodnough
authors.forename: R
authors.initials: R
authors.lastname: Brown
authors.forename: J
authors.initials: J
authors.lastname: DiPersio
mesh_terms: D000293:Adolescent; D000666:Amphotericin B / Q000627:therapeutic use*; D000935:Antifungal Agents / Q000627:therapeutic use*; D001228:Aspergillosis / Q000188:drug therapy* / Q000209:etiology; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D004338:Drug Combinations; D004660:Encephalitis / Q000188:drug therapy* / Q000209:etiology; D005260:Female; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000150:complications / Q000628:therapy; D010713:Phosphatidylcholines / Q000627:therapeutic use*; D010715:Phosphatidylglycerols / Q000627:therapeutic use*; D011379:Prognosis
chemical_list: D000935:Antifungal Agents; D004338:Drug Combinations; D010713:Phosphatidylcholines; D010715:Phosphatidylglycerols; C068538:liposomal amphotericin B; D000666:Amphotericin B