title: Studies on the site of renal tubular defect in Bartter's syndrome.
abstract: Renal tubular function was studied in an 8-month-old male infant with Bartter's syndrome, which is characterized by hypokalemic metabolic alkalosis, normotensive hyperreninemic hyperaldosteronism, and reduced pressor response to angiotensin II. Chloride transport along the diluting segment (CH2O/CH2O + CCl) was impaired. Furthermore, furosemide did not elicit normal natriuresis, which suggested impaired chloride reabsorptive capacity at the furosemide-sensitive ascending limb of Henle's loop. Loss of antidiuretic hormone-mediated urinary concentration was in support of this. These findings pointed to the thick ascending limb of Henle's loop as the site of the primary defect in this child.
authors.affiliation: Department of Pediatrics, Hitachi General Hospital, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Kikuchi
authors.forename: M
authors.initials: M
authors.lastname: Sato
authors.forename: A
authors.initials: A
authors.lastname: Chiba
authors.forename: Y
authors.initials: Y
authors.lastname: Chiba
authors.forename: K
authors.initials: K
authors.lastname: Nagao
authors.forename: T
authors.initials: T
authors.lastname: Suzuki
authors.forename: Y
authors.initials: Y
authors.lastname: Fujigaki
authors.forename: H
authors.initials: H
authors.lastname: Hoshino
mesh_terms: D001477:Bartter Syndrome / Q000503:physiopathology*; D002712:Chlorides / Q000378:metabolism; D004231:Diuresis; D004232:Diuretics; D005665:Furosemide; D006801:Humans; D007223:Infant; D008138:Loop of Henle / Q000503:physiopathology*; D008297:Male; D012965:Sodium Chloride / Q000378:metabolism
chemical_list: D002712:Chlorides; D004232:Diuretics; D012965:Sodium Chloride; D005665:Furosemide