title: Colorectal dysplasia and carcinoma in patients with ulcerative colitis and primary sclerosing cholangitis.
abstract: BACKGROUND
  The aim of this study was to evaluate the role of primary sclerosing cholangitis (PSC) as a cofactor in the dysplasia-carcinoma sequence in ulcerative colitis (UC).
  
  
  METHODS
  Forty-five patients with UC and concomitant PSC and 45 pair-matched control patients with UC only were examined for colorectal dysplasia and carcinoma.
  
  
  RESULTS
  The median duration of UC was 11 years in the group with UC and PSC and 15 years in the control group. Thirteen of the 45 patients (29%) with UC and PSC had colorectal neoplasia: 4, carcinoma; 2, high-grade dysplasia; and 7, low-grade dysplasia. Four of the 45 control patients (9%) had neoplastic findings: 1, carcinoma; 1, high-grade dysplasia, and 2, low-grade dysplasia (P < 0.05).
  
  
  CONCLUSIONS
  The results suggest that the risk of colorectal dysplasia and carcinoma in patients with UC is increased by concomitant PSC.
authors.affiliation: Fourth Dept. of Surgery, Helsinki University Central Hospital, Finland.
authors.forename: M H
authors.initials: MH
authors.lastname: Leidenius
authors.forename: M A
authors.initials: MA
authors.lastname: Färkkilä
authors.forename: P
authors.initials: P
authors.lastname: Kärkkäinen
authors.forename: E I
authors.initials: EI
authors.lastname: Taskinen
authors.forename: I H
authors.initials: IH
authors.lastname: Kellokumpu
authors.forename: K A
authors.initials: KA
authors.lastname: Höckerstedt
mesh_terms: D000328:Adult; D017668:Age of Onset; D016022:Case-Control Studies; D015209:Cholangitis, Sclerosing / Q000453:epidemiology*; D003093:Colitis, Ulcerative / Q000453:epidemiology*; D015179:Colorectal Neoplasms / Q000453:epidemiology*; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D012307:Risk Factors; D013997:Time Factors