title: Secondary acute monocytic leukemia occurring during the treatment of a testicular germ cell tumor. A case report and review of the literature.
abstract: Secondary leukemia following chemotherapy or radiotherapy for mediastinal germ cell tumors is a well-described entity. It also may occur in patients with testicular germ cell tumors. We report a case of acute monocytic leukemia occurring in a 44-year-old man who received etoposide-based chemotherapy and radiotherapy for a recurrent, metastatic testicular germ cell tumor. The patient received 14 cycles of systemic chemotherapy for pulmonary and para-aortic lymph node metastases following his initial orchiectomy. The total amount of etoposide this patient received was 6,400 mg/m2. Leukemia occurred 11 years after orchiectomy. A literature review revealed 25 other reported cases of secondary leukemias after treatment for testicular carcinoma. It is not clear whether chemotherapy, radiotherapy or both are responsible for the secondary leukemias seen in these patients.
authors.affiliation: Department of Urology, Osaka University Medical School, Japan. nono@uro.med.osaka-u.ac.jp
authors.forename: N
authors.initials: N
authors.lastname: Nonomura
authors.forename: N
authors.initials: N
authors.lastname: Murosaki
authors.forename: Y
authors.initials: Y
authors.lastname: Kojima
authors.forename: N
authors.initials: N
authors.lastname: Kondoh
authors.forename: T
authors.initials: T
authors.lastname: Seguchi
authors.forename: Y
authors.initials: Y
authors.lastname: Takeda
authors.forename: Y
authors.initials: Y
authors.lastname: Oji
authors.forename: H
authors.initials: H
authors.lastname: Ogawa
authors.forename: H
authors.initials: H
authors.lastname: Sugiyama
authors.forename: T
authors.initials: T
authors.lastname: Miki
authors.forename: A
authors.initials: A
authors.lastname: Okuyama
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003131:Combined Modality Therapy; D018237:Germinoma / Q000628:therapy*; D006801:Humans; D007948:Leukemia, Monocytic, Acute / Q000209:etiology*; D008297:Male; D016609:Neoplasms, Second Primary; D009919:Orchiectomy; D011879:Radiotherapy Dosage; D013736:Testicular Neoplasms / Q000628:therapy*