title: Selenium status in pregnant women of a rural population (Zaire) in relationship to iodine deficiency.
abstract: Endemic myxoedematous cretinism has been associated with combined selenium and iodine deficiency in several areas of Zaire. To determine selenium and iodine status across the country, serum selenium and thyroid function parameters including urinary iodide were determined at prenatal clinics in 30 health centres of rural villages distributed over the whole country. Only in Bas-Zaire was the mean serum selenium level similar to that in non-deficient areas (80-120 ng/ml); in the regions of Bandunda and Kasai levels were marginally decreased (55-80 ng/ml), and in Kivu, Haut-Zaire, Equateur and Shaba they were marginally or moderately decreased (< 55 ng/ml). The frequency of abnormally low urinary iodide (< 5 micrograms/dl) varied from 20% in the region of Bas-Zaire to 50% in Kasai (P < 0.001), and to still higher percentages in the 5 other regions of Zaire (Bandundu, 57%; Kivu, 63%; Equateur, 72%; Shaba, 76%; Haut-Zaire, 84%). With the exception of Bas-Zaire, biochemical maternal hypothyroidism (serum TSH > 5mU/l) was present in every region, with a frequency ranging from 3% in Kivu to 12% in Equateur. Iodine deficiency affects most of the Zairean population and requires public health measures on a larger scale than previously estimated. Combined iodine and selenium deficiency affects Equateur, Haut-Zaire and Kivu, where endemic myxoedematous cretinism occurs, but also Shaba, where it was not previously described. Besides combined iodine and selenium deficiency which is permissive, another factor (thiocyanate?) must be taken into account to explain the peculiarly elevated prevalence of endemic myxoedematous cretinism in Central Africa.
authors.affiliation: Ecole de Santé Publique, UNIKIN, Kinshasa, Zaire.
authors.forename: D B
authors.initials: DB
authors.lastname: Ngo
authors.forename: L
authors.initials: L
authors.lastname: Dikassa
authors.forename: W
authors.initials: W
authors.lastname: Okitolonda
authors.forename: T D
authors.initials: TD
authors.lastname: Kashala
authors.forename: C
authors.initials: C
authors.lastname: Gervy
authors.forename: J
authors.initials: J
authors.lastname: Dumont
authors.forename: N
authors.initials: N
authors.lastname: Vanovervelt
authors.forename: B
authors.initials: B
authors.lastname: Contempré
authors.forename: A T
authors.initials: AT
authors.lastname: Diplock
authors.forename: S
authors.initials: S
authors.lastname: Peach
authors.forename: J
authors.initials: J
authors.lastname: Vanderpas
mesh_terms: D003409:Congenital Hypothyroidism / Q000209:etiology; D015023:Democratic Republic of the Congo; D019353:Endemic Diseases; D005260:Female; D006043:Goiter, Endemic; D006801:Humans; D007454:Iodides / Q000652:urine; D007455:Iodine / Q000172:deficiency*; D011247:Pregnancy / Q000097:blood* / Q000652:urine; D012423:Rural Health; D012643:Selenium / Q000097:blood* / Q000172:deficiency; D013963:Thyroid Hormones / Q000097:blood
chemical_list: D007454:Iodides; D013963:Thyroid Hormones; D007455:Iodine; D012643:Selenium