Fungemia in cancer patients undergoing chemotherapy versus surgery: risk factors, etiology and outcome.
26 patients with fungemia and cancer treated with chemotherapy (group A) were compared to 25 patients with fungemia and cancer treated with surgery (group B), to assess differences in etiology, risk factors and outcome. Candida albicans was responsible for 42% of fungemias in group A, and for 92% of fungemias in group B (p < 0.005). Breakthrough fungemia occurring during antifungal prophylaxis appeared in 46.6% of group A vs 12% of group B (p < 0.02). There was significant difference in outcome between the groups: 20% of patients after surgery vs 7.7% of those after chemotherapy died from fungemia (p < 0.04). Most common risk factors recorded in both groups were catheter insertion and previous therapy with broad spectrum antibiotics.
Kralovicova
K
K
Department of Medicine, Post-graduate Medical School, University of Trnava, Slovakia.
Spanik
S
S
Oravcova
E
E
Mrazova
M
M
Morova
E
E
Gulikova
V
V
Kukuckova
E
E
Koren
P
P
Pichna
P
P
Nogova
J
J
Kunova
A
A
Trupl
J
J
Krcmery
V
V
D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D019072:Antibiotic Prophylaxis; D000935:Antifungal Agents / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002177:Candidiasis / Q000209:etiology* / Q000401:mortality; D016022:Case-Control Studies; D002408:Catheters, Indwelling / Q000382:microbiology; D016469:Fungemia / Q000209:etiology* / Q000401:mortality; D005658:Fungi / Q000302:isolation & purification; D006801:Humans; D015999:Multivariate Analysis; D009369:Neoplasms / Q000150:complications* / Q000188:drug therapy / Q000601:surgery; D009503:Neutropenia / Q000150:complications; D012307:Risk Factors; D015003:Yeasts / Q000302:isolation & purification
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D000970:Antineoplastic Agents