title: Antibody responses to tetanus toxoid and Haemophilus influenzae type b conjugate vaccines following autologous peripheral blood stem cell transplantation (PBSCT).
abstract: Accelerated granulocyte and platelet recovery following peripheral blood stem cell transplantation (PBSCT) are well documented. We hypothesize that functional immunity may also be enhanced in PBSCT and performed a phase II trial of immunizations in patients with lymphoma undergoing autologous transplantation with peripheral blood stem cells or bone marrow. Seventeen BMT and 10 PBSCT recipients were immunized at 3, 6, 12, and 24-months post-transplantation with Haemophilus influenzae type b (HIB)-conjugate and tetanus toxoid (TT) vaccines. IgG anti-HIB and anti-TT antibody concentrations were measured and compared between the two groups. Geometric mean IgG anti-HIB antibody concentrations were significantly higher for PBSCT recipients compared to BMT recipients at 24 months post-transplantation (11.3 micrograms/ml vs 0.93 microgram/ml, P = 0.051) and following the 24 month immunization (66.2 micrograms/ml vs 1.30 micrograms/ml, P = 0.006). Similar results were noted for IgG anti-TT antibody with significantly higher geometric mean antibody concentrations in the PBSCT group at 24 months post-transplantation (182 micrograms/ml vs 21.6 micrograms/ml, P = 0.039). Protective levels of total anti-HIB antibody were achieved earlier in PBSCT recipients compared with those of BMT recipients. PBSCT recipients had higher antigen-specific antibody concentrations following HIB and TT immunizations. These results suggest enhanced recovery of humoral immunity in PBSCT recipients and earlier protection against HIB with immunization.
authors.affiliation: Laboratory of Infectious Diseases, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
authors.forename: C Y
authors.initials: CY
authors.lastname: Chan
authors.forename: D C
authors.initials: DC
authors.lastname: Molrine
authors.forename: J H
authors.initials: JH
authors.lastname: Antin
authors.forename: C
authors.initials: C
authors.lastname: Wheeler
authors.forename: E C
authors.initials: EC
authors.lastname: Guinan
authors.forename: H J
authors.initials: HJ
authors.lastname: Weinstein
authors.forename: N R
authors.initials: NR
authors.lastname: Phillips
authors.forename: C
authors.initials: C
authors.lastname: McGarigle
authors.forename: S
authors.initials: S
authors.lastname: Harvey
authors.forename: C
authors.initials: C
authors.lastname: Schnipper
authors.forename: D M
authors.initials: DM
authors.lastname: Ambrosino
mesh_terms: D000328:Adult; D000907:Antibodies, Bacterial / Q000097:blood* / Q000276:immunology; D001424:Bacterial Infections / Q000517:prevention & control; D005260:Female; D018073:Haemophilus Vaccines / Q000008:administration & dosage / Q000276:immunology; D006193:Haemophilus influenzae / Q000276:immunology*; D018380:Hematopoietic Stem Cell Transplantation; D006689:Hodgkin Disease / Q000097:blood / Q000276:immunology / Q000628:therapy*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D007165:Immunosuppression Therapy / Q000009:adverse effects; D008228:Lymphoma, Non-Hodgkin / Q000097:blood / Q000276:immunology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D013745:Tetanus Toxoid / Q000008:administration & dosage / Q000276:immunology*; D014182:Transplantation, Autologous; D018074:Vaccines, Conjugate / Q000008:administration & dosage* / Q000276:immunology
chemical_list: D000907:Antibodies, Bacterial; D018073:Haemophilus Vaccines; D007074:Immunoglobulin G; D013745:Tetanus Toxoid; D018074:Vaccines, Conjugate