title: Late regression of the dilated site after coronary angioplasty: a 5-year quantitative angiographic study.
abstract: BACKGROUND
  Limited data are available on the changes that occur at the dilated site late after coronary angioplasty. The aim of this study was to evaluate with quantitative angiography the natural history of changes that occur in the dilated segment between "early" (approximately 6 months) and "late" (approximately 5 years) follow-up after angioplasty.
  
  
  RESULTS
  Of 127 consecutive patients (174 lesions) with successful angioplasty, 125 underwent early angiography. Three patients subsequently died, and 24 underwent revascularization surgery or repeated angioplasty, giving a study-eligible population of 98 patients. Quantitative angiographic analysis was performed before and immediately after angioplasty and at early and late follow-up in the study population of 84 patients (115 lesions), which was 86% of study-eligible patients. Mean lesion diameter stenosis decreased from 36.3+/-14.2% at early to 29.6+/-13.5% at late follow-up (P<.0001). No lesion developed late restenosis by the 50% diameter loss criterion. Late regression was related to stenosis severity at early angiography (r=-.58, P<.001). Subgroups at early angiography of 40% to 49% stenosis and > or = 50% stenosis showed significant regression at late angiography.
  
  
  CONCLUSIONS
  Lesion regression at the dilated site is common late after angioplasty. The more severe a stenosis is at early angiography, the more likely the chance that there will be late regression. A strategy of watchful waiting may be appropriate for patients with restenotic lesions of borderline severity.
authors.affiliation: Green Lane Hospital, Epsom, Auckland, New Zealand.
authors.forename: J A
authors.initials: JA
authors.lastname: Ormiston
authors.forename: F M
authors.initials: FM
authors.lastname: Stewart
authors.forename: A H
authors.initials: AH
authors.lastname: Roche
authors.forename: B J
authors.initials: BJ
authors.lastname: Webber
authors.forename: R M
authors.initials: RM
authors.lastname: Whitlock
authors.forename: M W
authors.initials: MW
authors.lastname: Webster
mesh_terms: D000328:Adult; D000800:Angioplasty, Balloon; D017023:Coronary Angiography; D003327:Coronary Disease / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000628:therapy*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D014463:Ultrasonography