title: Biological activities of pseudomycin A, a lipodepsinonapeptide from Pseudomonas syringae MSU 16H.
abstract: Similarly to other Pseudomonas lipodepsinonapeptides, pseudomycin A inhibits proton extrusion from maize roots, promotes closure of stomata in Vicia faba, necrosis of tobacco leaves, haemolysis of human erythrocytes, affects H(+)-ATPase activity and proton translocation in plasma membrane vesicles, and stimulates succinate respiration in pea mitochondria. In general, the biological activities of pseudomycin A are lower than those of syringomycin-E, the prototype member of this family of bacterial metabolities. This difference might depend on the diverse number and distribution of charged residues in the peptide moiety of these compounds.
authors.affiliation: Dipartimento di Scienze Biochimiche A. Rossi-Fanelli, Università La Sapienza, Rome, Italy.
authors.forename: D
authors.initials: D
authors.lastname: Di Giorgio
authors.forename: L
authors.initials: L
authors.lastname: Camoni
authors.forename: C
authors.initials: C
authors.lastname: Marchiafava
authors.forename: A
authors.initials: A
authors.lastname: Ballio
mesh_terms: D000595:Amino Acid Sequence; D001426:Bacterial Proteins / Q000494:pharmacology* / Q000633:toxicity; D002462:Cell Membrane / Q000187:drug effects / Q000201:enzymology; D004912:Erythrocytes / Q000187:drug effects; D006461:Hemolysis; D006801:Humans; D008928:Mitochondria / Q000187:drug effects / Q000502:physiology; D018532:Pisum sativum / Q000187:drug effects / Q000502:physiology; D010456:Peptides, Cyclic / Q000494:pharmacology* / Q000633:toxicity; D018515:Plant Leaves / Q000187:drug effects / Q000378:metabolism; D018517:Plant Roots / Q000187:drug effects / Q000378:metabolism; D010944:Plants / Q000187:drug effects*; D010947:Plants, Toxic; D006180:Proton-Translocating ATPases / Q000378:metabolism; D011549:Pseudomonas / Q000737:chemistry*; D014026:Nicotiana / Q000187:drug effects / Q000378:metabolism; D003313:Zea mays / Q000187:drug effects / Q000378:metabolism
chemical_list: D001426:Bacterial Proteins; D010456:Peptides, Cyclic; C107665:pseudomycin A; D006180:Proton-Translocating ATPases