title: [Glutathione peroxidases: value of their determination in clinical biology].
abstract: The role of glutathione peroxidase in the oxidative metabolism and recent advances in the demonstration of the consequences of the desequilibrium in the proxidant/antioxidant balance on biological molecules oxidation, intracellular signals transduction, apoptosis and necrosis, have led to new approach in the knowledge of many pathological processes. Methods for determining antioxidant capacity have been developed. The measurement of glutathione peroxidase activity is a key step in the study of oxidative stress. Its determination in clinical biology needs optimal conditions for standardised assays which will be used for epidemiological studies aimed to evaluate the role of nutritional factors involved in the pathogeny of diseases caused or accompanied by oxidative stress.
authors.affiliation: Laboratoire de biochimie C, CHU A.-Michallon, Grenoble.
authors.forename: M J
authors.initials: MJ
authors.lastname: Richard
authors.forename: F
authors.initials: F
authors.lastname: Belleville
authors.forename: J
authors.initials: J
authors.lastname: Chalas
authors.forename: I
authors.initials: I
authors.lastname: Ceballos-Picot
authors.forename: D
authors.initials: D
authors.lastname: Vitoux
authors.forename: M J
authors.initials: MJ
authors.lastname: Boyer
authors.forename: J
authors.initials: J
authors.lastname: Chaudière
authors.forename: A
authors.initials: A
authors.lastname: Favier
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000743:Anemia, Hemolytic / Q000201:enzymology; D002648:Child; D004700:Endocrine System Diseases / Q000201:enzymology; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood* / Q000737:chemistry / Q000378:metabolism; D015658:HIV Infections / Q000201:enzymology; D006331:Heart Diseases / Q000201:enzymology; D006801:Humans; D008875:Middle Aged; D009369:Neoplasms / Q000201:enzymology; D018384:Oxidative Stress; D011247:Pregnancy; D051437:Renal Insufficiency / Q000201:enzymology; D012643:Selenium / Q000032:analysis
chemical_list: D005979:Glutathione Peroxidase; D012643:Selenium
vernacular_title: Les glutathion peroxydases: intérêt de leur dosage en biologie clinique.