[The effect of prenatal diethylstilbestrol treatment on 1,2-dimethylhydrazine-induced carcinogenesis in C3HA female mice].
C3HA female mice received 0.1-0.3 mg/g body weight diethylstilbestrol (DES) on day 17 of gestation. Their descendants received a total of 20 injections of 1.2-dimethylhydrazine (DMH), subcutaneously, weekly, starting from month 2. Prenatal DES significantly inhibited the development of DMH-induced clitoral gland tumors, particularly, hemorrhagic ovarian cysts which were the frequent cause of death due to their rupture into the abdominal cavity. A significant decrease in cyst incidence resulted in higher survival in mice receiving combined therapy. The results were attributed to DES-induced hyperestrogenization which was confirmed by vaginal smears examination.
Morozova
O V
OV
Lanko
N S
NS
Politova
S N
SN
Turusov
V S
VS
D019813:1,2-Dimethylhydrazine; D000818:Animals; D002273:Carcinogens / Q000037:antagonists & inhibitors*; D004054:Diethylstilbestrol / Q000494:pharmacology*; D004127:Dimethylhydrazines / Q000037:antagonists & inhibitors*; D005260:Female; D005833:Genital Neoplasms, Female / Q000139:chemically induced / Q000517:prevention & control*; D005865:Gestational Age; D051379:Mice; D008809:Mice, Inbred C3H; D014626:Vaginal Smears
D002273:Carcinogens; D004127:Dimethylhydrazines; D004054:Diethylstilbestrol; D019813:1,2-Dimethylhydrazine
Vliianie prenatal'nogo vozdeĭstviia diétilstilbéstrola na kantserogenez, indutsiruemyĭ 1,2-dimetilgidrazinom u mysheĭ-samok linii C3HA.