title: Calmodulin-regulated adenylyl cyclases and neuromodulation.
abstract: Coincidence detection and crosstalk between signal transduction systems play very important regulatory roles in the nervous system, particularly in the regulation of transcription. Coupling of the Ca2+ and cAMP regulatory systems by calmodulin-regulated adenylyl cyclases is hypothesized to be important for some forms of synaptic plasticity, neuroendocrine function, and olfactory detection. Recent studies of a mutant mouse deficient in type I calmodulin-sensitive adenylyl cyclase have provided the first evidence that adenylyl cyclases are important for synaptic plasticity, as well as for learning and memory in vertebrates.
authors.affiliation: Department of Environmental Health and Toxicology, University of Washington School of Public Health, Seattle, Washington 98195, USA. zxia@dehpost.sphcm.washington.edu
authors.forename: Z
authors.initials: Z
authors.lastname: Xia
authors.forename: D R
authors.initials: DR
authors.lastname: Storm
mesh_terms: D000262:Adenylyl Cyclases / Q000187:drug effects*; D000818:Animals; D002147:Calmodulin / Q000494:pharmacology*; D000242:Cyclic AMP / Q000502:physiology*; D008550:Melatonin / Q000378:metabolism; D051379:Mice; D015398:Signal Transduction / Q000502:physiology; D012903:Smell / Q000502:physiology
chemical_list: D002147:Calmodulin; D000242:Cyclic AMP; D000262:Adenylyl Cyclases; D008550:Melatonin