title: The role of anxiety sensitivity in the pathogenesis of panic: prospective evaluation of spontaneous panic attacks during acute stress.
abstract: Expectancy theory posits that anxiety sensitivity may serve as a premorbid risk factor for the development of anxiety pathology (S. Reiss, 1991). The principal aim of the present study was to determine whether anxiety sensitivity acts as a specific vulnerability factor in the pathogenesis of anxiety pathology. A large, nonclinical sample of young adults (N = 1,401) was prospectively followed over a 5-week highly stressful period of time (i.e., military basic training). Anxiety sensitivity was found to predict the development of spontaneous panic attacks after controlling for a history of panic attacks and trait anxiety. Approximately 20% of those scoring in the upper decile on the Anxiety Sensitivity Index (R. A. Peterson & S. Reiss, 1987) experienced a panic attack during the 5-week follow-up period compared with only 6% for the remainder of the sample. Anxiety sensitivity also predicted anxiety symptomatology, functional impairment created by anxiety, and disability. These data provide strong evidence for anxiety sensitivity as a risk factor in the development of panic attacks and other anxiety symptoms.
authors.affiliation: Department of Medical and Clinical Psychology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814-4799, USA. schmidt@usuhsb.usuhs.mil
authors.forename: N B
authors.initials: NB
authors.lastname: Schmidt
authors.forename: D R
authors.initials: DR
authors.lastname: Lerew
authors.forename: R J
authors.initials: RJ
authors.lastname: Jackson
mesh_terms: D000293:Adolescent; D000328:Adult; D001007:Anxiety / Q000175:diagnosis / Q000523:psychology*; D001143:Arousal; D005239:Fear; D006801:Humans; D008960:Models, Psychological; D016584:Panic Disorder / Q000209:etiology* / Q000523:psychology; D010551:Personality; D010555:Personality Inventory; D011446:Prospective Studies; D012307:Risk Factors; D013315:Stress, Psychological / Q000150:complications* / Q000523:psychology