Biological activities of pseudomycin A, a lipodepsinonapeptide from Pseudomonas syringae MSU 16H.
Similarly to other Pseudomonas lipodepsinonapeptides, pseudomycin A inhibits proton extrusion from maize roots, promotes closure of stomata in Vicia faba, necrosis of tobacco leaves, haemolysis of human erythrocytes, affects H(+)-ATPase activity and proton translocation in plasma membrane vesicles, and stimulates succinate respiration in pea mitochondria. In general, the biological activities of pseudomycin A are lower than those of syringomycin-E, the prototype member of this family of bacterial metabolities. This difference might depend on the diverse number and distribution of charged residues in the peptide moiety of these compounds.
Di Giorgio
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Dipartimento di Scienze Biochimiche A. Rossi-Fanelli, Università La Sapienza, Rome, Italy.
Camoni
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Marchiafava
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Ballio
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D000595:Amino Acid Sequence; D001426:Bacterial Proteins / Q000494:pharmacology* / Q000633:toxicity; D002462:Cell Membrane / Q000187:drug effects / Q000201:enzymology; D004912:Erythrocytes / Q000187:drug effects; D006461:Hemolysis; D006801:Humans; D008928:Mitochondria / Q000187:drug effects / Q000502:physiology; D018532:Pisum sativum / Q000187:drug effects / Q000502:physiology; D010456:Peptides, Cyclic / Q000494:pharmacology* / Q000633:toxicity; D018515:Plant Leaves / Q000187:drug effects / Q000378:metabolism; D018517:Plant Roots / Q000187:drug effects / Q000378:metabolism; D010944:Plants / Q000187:drug effects*; D010947:Plants, Toxic; D006180:Proton-Translocating ATPases / Q000378:metabolism; D011549:Pseudomonas / Q000737:chemistry*; D014026:Nicotiana / Q000187:drug effects / Q000378:metabolism; D003313:Zea mays / Q000187:drug effects / Q000378:metabolism
D001426:Bacterial Proteins; D010456:Peptides, Cyclic; C107665:pseudomycin A; D006180:Proton-Translocating ATPases