Long-term follow up of ionic plasma fluoride level in patients receiving hemodialysis treatment.
The elimination half-life of fluoride is significantly increased in patients with chronic renal failure. This led us to conduct a study of variations of its plasma levels in 35 patients receiving dialysis treatment. In this population, there is a gaussian distribution of the values before and after the hemodialysis session, with a significant decrease in the averages. Furthermore, there is a highly significant correlation between fluoride levels before and after the dialysis session (P < 0.00001), and also between the amount of time in hemodialysis (in months) and the average fluoride level before dialysis (r = 0.624; P = 0.008). The presence of a group of patients consuming fluoride waters such as Vichy St-Yorre Water was easily identified by their excessive fluoride levels (above 100 micrograms/l), which could have a tendency to increase the risks of this group.
Nicolay
A
A
Laboratoire de contrôle et de fabrication, Hôpital Ste Marguerite, Marseille, France.
Bertocchio
P
P
Bargas
E
E
Reynier
J P
JP
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005459:Fluorides / Q000008:administration & dosage / Q000009:adverse effects / Q000097:blood*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D008900:Mineral Waters / Q000009:adverse effects / Q000032:analysis; D006435:Renal Dialysis; D013997:Time Factors
D008900:Mineral Waters; D005459:Fluorides