title: Magnetic resonance imaging and signal-averaged electrocardiography in patients with repetitive monomorphic ventricular tachycardia and otherwise normal electrocardiogram.
abstract: Early or localized forms of arrhythmogenic right ventricular dysplasia (ARVD) have been proposed as the arrhythmogenic substrate of repetitive monomorphic ventricular tachycardia (RMVT) originating in the right ventricular outflow tract in patients without any underlying cardiac abnormality on clinical examination and echocardiography. To further examine this hypothesis, magnetic resonance imaging (MRI) and signal-averaged electrocardiography (SAECG) were performed on 23 patients with RMVT and normal 12-lead standard ECG of conducted sinus beats. MRI was performed using ECG-gated turbo spin-echo images of the heart in order to detect signs of early or localized forms of ARVD, such as localized wall thickness reductions, signal intensity increase indicating adipose tissue infiltrates, and regional bulgings or aneurysms. MRI was normal in 22 (96%) of 23 study patients. In the remaining patient (4%), MRI demonstrated signal intensity increase in the intraventricular septum but not in the right ventricular outflow tract. Time-domain analysis of the SAECG was normal in 21 (91%) of 23 patients and revealed ventricular late potentials in 2 study patients (9%). Frequency-domain analysis of the SAECG was normal in 22 (96%) of 23 patients and revealed ventricular late potentials in one study patient (4%). We conclude that normal MRI findings of the heart and absence of ventricular late potentials in the SAECG in most patients with RMVT and otherwise normal ECG do not support the hypothesis that early or localized forms of ARVD create the arrhythmogenic substrate in the majority of these patients.
authors.affiliation: Department of Cardiology, Philipps-University Marburg, Germany.
authors.forename: W
authors.initials: W
authors.lastname: Grimm
authors.forename: E
authors.initials: E
authors.lastname: List-Hellwig
authors.forename: J
authors.initials: J
authors.lastname: Hoffmann
authors.forename: V
authors.initials: V
authors.lastname: Menz
authors.forename: R
authors.initials: R
authors.lastname: Hahn-Rinn
authors.forename: K J
authors.initials: KJ
authors.lastname: Klose
authors.forename: B
authors.initials: B
authors.lastname: Maisch
mesh_terms: D000200:Action Potentials / Q000502:physiology; D000273:Adipose Tissue / Q000473:pathology; D000293:Adolescent; D000328:Adult; D000368:Aged; D018780:Body Surface Potential Mapping; D006328:Cardiac Catheterization; D002304:Cardiac Pacing, Artificial; D004452:Echocardiography; D004562:Electrocardiography / Q000379:methods*; D015716:Electrocardiography, Ambulatory; D005260:Female; D005500:Follow-Up Studies; D006322:Heart Aneurysm / Q000175:diagnosis / Q000503:physiopathology; D006346:Heart Septum / Q000473:pathology; D006352:Heart Ventricles / Q000002:abnormalities / Q000000981:diagnostic imaging; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D011664:Pulmonary Valve / Q000002:abnormalities / Q000000981:diagnostic imaging; D012815:Signal Processing, Computer-Assisted; D017180:Tachycardia, Ventricular / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000503:physiopathology