Repeated administration intensifies the reinforcing effect of fencamfamine in rats.
1. In the present study, we evaluated the role of repeated administration on conditioning place preference (CPP) induced by fencamfamine (FCF) in male rats. 2. Repeated FCF (3.5 mg/kg) or saline once or daily for ten consecutive days enhanced sniffing duration and decreased locomotion and rearing duration. 3. At the 3.5 mg/kg dose, FCF produced a significant place-preference effect. 4. Repeated exposures to FCF intensified its reinforcing properties. 5. These results suggest that repeated FCF administration sensitizes its rewarding effects, as with other addictive substances.
DeLucia
R
R
Departamento de Farmacologia, Unviersidade de São Paulo, Brazil.
Planeta
C S
CS
Aizenstein
M L
ML
Scavone
C
C
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D000697:Central Nervous System Stimulants / Q000008:administration & dosage*; D003214:Conditioning, Classical / Q000187:drug effects*; D018491:Dopamine Agonists / Q000008:administration & dosage*; D008297:Male; D009636:Norbornanes / Q000008:administration & dosage*; D051381:Rats; D017208:Rats, Wistar
D000697:Central Nervous System Stimulants; D018491:Dopamine Agonists; D009636:Norbornanes; C020900:fencamfamine