Synthesis of sodium androst-5-ene-17-one-3 beta-methylene sulfonate.
The synthesis of sodium androst-5-ene-17-one-3 beta-methylene sulfonate 2, a stable analog of memory-enhancing neurosteroid dehydroepiandrosterone sulfate, is described. The synthesis of compound 2 is carried out in six steps from dehydroepiandrosterone.
Chu
G H
GH
Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, PA 15282, USA.
Li
P K
PK
D019314:Dehydroepiandrosterone Sulfate / Q000138:chemical synthesis / Q000737:chemistry*
C108252:androst-5-ene-17-one-3-methylene sulfonic acid; D019314:Dehydroepiandrosterone Sulfate