title: Successive transformation of chronic myelomonocytic leukaemia into acute myeloblastic then lymphoblastic leukaemia, both with minor-bcr rearrangement.
abstract: We report a case of chronic myelomonocytic leukaemia (CMML), which transformed first into acute myeloblastic leukaemia (AML) and then into acute lymphoblastic leukaemia (ALL). In the AML and ALL phases, chromosome analysis showed a classic Philadelphia chromosome (Ph) t(9:22)(q34:q11). Molecular studies showed breakpoint cluster region rearrangement between exons e1 and a2 compatible with a p190(bcr/abl) breakpoint as observed in Ph-positive lymphoblastic acute leukaemia. The minor (m-bcr) rearrangement was also detected during complete remission. This observation supports a multistep pathogenesis of leukaemias, and that the p190(bcr/abl) breakpoint may influence the course of the disease.
authors.affiliation: Laboratoire d'Hématologie, CDTS Angers, France.
authors.forename: M M
authors.initials: MM
authors.lastname: Dautel
authors.forename: S
authors.initials: S
authors.lastname: François
authors.forename: M F
authors.initials: MF
authors.lastname: Bertheas
authors.forename: L
authors.initials: L
authors.lastname: Baranger
authors.forename: J
authors.initials: J
authors.lastname: Gardais
authors.forename: M
authors.initials: M
authors.lastname: Boasson
authors.forename: N
authors.initials: N
authors.lastname: Ifrah
authors.forename: O
authors.initials: O
authors.lastname: Blanchet
mesh_terms: D000368:Aged; D002471:Cell Transformation, Neoplastic; D002892:Chromosomes, Human, Pair 22; D002899:Chromosomes, Human, Pair 9; D018450:Disease Progression; D016044:Fusion Proteins, bcr-abl / Q000235:genetics; D015321:Gene Rearrangement; D006801:Humans; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000235:genetics / Q000473:pathology*; D015477:Leukemia, Myelomonocytic, Chronic / Q000235:genetics / Q000473:pathology*; D008297:Male; D016133:Polymerase Chain Reaction; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics / Q000473:pathology*; D014178:Translocation, Genetic
chemical_list: D016044:Fusion Proteins, bcr-abl