The Maginot Line and AIDS vaccines.
Despite extensive and costly efforts, attempts to develop a vaccine against human immunodeficiency virus (HIV), the causative agent of the acquired immunodeficiency syndrome (AIDS), have been unsuccessful. Using the Maginot Line as a metaphor, we discuss the reasons why an antibody-based vaccine strategy against HIV has failed. The concept of a vaccine that exclusively promotes cell-mediated immunity against the virus is outlined, and important factors in the formulation of this novel vaccine are delineated. In particular, vaccine adjuvants and HIV peptides that elicit a cell-mediated immune response are crucial components of this immunization strategy. Examination of primate immune systems that resist retroviral pathogenicity will also play an important role in the development of a successful AIDS vaccine.
Stricker
R B
RB
Department of Medicine, California Pacific Medical Center, San Francisco, USA.
Goldberg
B
B
D016915:AIDS Vaccines / Q000008:administration & dosage / Q000276:immunology / Q000302:isolation & purification*; D000276:Adjuvants, Immunologic / Q000008:administration & dosage; D000818:Animals; D006678:HIV / Q000276:immunology; D015483:HIV Antibodies / Q000096:biosynthesis; D015658:HIV Infections / Q000276:immunology / Q000517:prevention & control; D006801:Humans; D007111:Immunity, Cellular; D008954:Models, Biological; D018417:Th1 Cells / Q000276:immunology
D016915:AIDS Vaccines; D000276:Adjuvants, Immunologic; D015483:HIV Antibodies