Effect of L-arginine on in vitro plasmin-generation and fibrinogenolysis.
L-arginine ahs received much attention in numerous aspects of the regulation of vascular tone and haemostasis. L-arginine seems to be capable to bind to plasminogen, too. The aim of the present paper is to investigate the action of L-arginine on in vitro plasmin generation and fibrino(geno)lysis by chromogenic, kinetic plasmin generation assay and electrophoretic analysis. The acceleration of tPA-induced plasmin generation in the presence of low concentration of L-arginine, along with augmentation of in vitro fibrinogenolysis have been documented. L-arginine may have a role in the modification of fibrinogenolysis, and this role should be considered if arginine is used as an element of some novel antithrombotic agents.
Udvardy
M
M
2nd Department of Medicine and Institute of Clinical Chemistry, University Medical School, Debrecen, Hungary.
Posán
E
E
Palatka
K
K
Altorjay
I
I
Harsfalvi
J
J
D001120:Arginine / Q000378:metabolism* / Q000494:pharmacology; D005340:Fibrinogen / Q000378:metabolism*; D005341:Fibrinolysin / Q000378:metabolism*; D006801:Humans; D007700:Kinetics
D005340:Fibrinogen; D001120:Arginine; D005341:Fibrinolysin