title: Exercise testing in the preoperative evaluation of patients with bronchogenic carcinoma.
abstract: The aim of this study was to evaluate which parameters of preoperative spirometry and cardiopulmonary exercise test are the best predictors of postoperative morbidity and mortality in patients with bronchogenic carcinoma. Ninety seven patients were prospectively and consecutively examined. All patients had preoperative maximal exercise test and dynamic spirometry. Postoperative complications and causes of death were registered. Logistic regression was used and models explaining the relationship between preoperative variables and postoperative complications and deaths were constructed. We found significant differences in preoperative maximal workload and carbon dioxide output between groups, with and without cardiopulmonary-related complications, but not in spirometry variables. Logistic regression showed maximal workload to be the only predictor of cardiopulmonary complications. Maximal oxygen uptake was predictive of cardiopulmonary deaths. Maximal oxygen uptake and forced expiratory volume were predictive of postoperative complications. A maximal oxygen uptake <50% predicted was associated with high risk of death from cardiopulmonary causes. Kaplan-Meier survival curves showed that maximal oxygen uptake was correlated to long-term survival, while spirometric variables were not. Exercise testing can be used in the preoperative evaluation of patients with nonmetastatic bronchogenic carcinoma. A combination of the results of variables from spirometry and exercise testing is proposed to be used as a preoperative criterion for operability.
authors.affiliation: Dept of Pulmonary Medicine, Gentofte Hospital, University of Copenhagen, Denmark.
authors.forename: K
authors.initials: K
authors.lastname: Richter Larsen
authors.forename: U G
authors.initials: UG
authors.lastname: Svendsen
authors.forename: N
authors.initials: N
authors.lastname: Milman
authors.forename: J
authors.initials: J
authors.lastname: Brenøe
authors.forename: B N
authors.initials: BN
authors.lastname: Petersen
mesh_terms: D002283:Carcinoma, Bronchogenic / Q000175:diagnosis* / Q000401:mortality / Q000601:surgery; D004562:Electrocardiography; D005080:Exercise Test / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D016015:Logistic Models; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000401:mortality / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009017:Morbidity; D011183:Postoperative Complications / Q000453:epidemiology; D011237:Predictive Value of Tests; D011300:Preoperative Care; D011446:Prospective Studies; D013147:Spirometry; D016019:Survival Analysis; D015996:Survival Rate