title: An evaluation of the relationship between 'atopic skin' and skin irritability in metalworker trainees.
abstract: Skin hyperirritability to irritants as well as atopy are considered to be predisposing factors for contact dermatitis. The aim of the study was to evaluate whether these predictive factors are independent or whether they are so closely related that one could possibly replace the other 205 metalworker trainees underwent skin examination for skin atopy, including standardized questionnaire, clinical examination of the skin and a series of skin irritability tests. These tests included measurements of transepidermal water loss (TEWL) before and after irritation with 3 different irritants: sodium lauryl sulfate (SLS), dimethylsulfoxide (DMSO) and sodium hydroxide (NaOH). The results of the linear regression analysis demonstrate that skin atopy is not associated with increased skin irritability, as assessed by the irritability testing methods presented.
authors.affiliation: Department of Dermatology, University of Zürich, Switzerland.
authors.forename: R
authors.initials: R
authors.lastname: Stolz
authors.forename: U
authors.initials: U
authors.lastname: Hinnen
authors.forename: P
authors.initials: P
authors.lastname: Elsner
mesh_terms: D000293:Adolescent; D000328:Adult; D003876:Dermatitis, Atopic / Q000150:complications* / Q000473:pathology; D003877:Dermatitis, Contact / Q000150:complications* / Q000209:etiology; D017453:Dermatitis, Irritant / Q000150:complications* / Q000209:etiology; D009783:Dermatitis, Occupational / Q000150:complications / Q000209:etiology; D004121:Dimethyl Sulfoxide / Q000009:adverse effects; D004342:Drug Hypersensitivity / Q000150:complications / Q000209:etiology; D005069:Evaluation Studies as Topic; D006801:Humans; D008297:Male; D008669:Metallurgy; D015999:Multivariate Analysis; D012044:Regression Analysis; D012882:Skin Tests; D012967:Sodium Dodecyl Sulfate / Q000009:adverse effects; D012972:Sodium Hydroxide / Q000009:adverse effects; D013557:Switzerland; D014870:Water Loss, Insensible / Q000187:drug effects
chemical_list: D012967:Sodium Dodecyl Sulfate; D012972:Sodium Hydroxide; D004121:Dimethyl Sulfoxide