title: Improvement of bronchial hyperresponsiveness in asthmatic children treated for concomitant sinusitis.
abstract: BACKGROUND
  There appears to be an association between sinusitis and asthma. The effect on bronchial hyperresponsiveness of clinical therapy for sinusitis in children may help to decipher whether sinusitis and asthma are independent manifestations of the same disease.
  
  
  OBJECTIVE
  To evaluate the effect of clinical treatment for sinusitis in patients with rhinitis and/or asthma on symptoms and on bronchial hyperresponsiveness to methacholine.
  
  
  METHODS
  Open label, randomized, non-treatment control in a teaching hospital in São Paulo, Brazil. Forty-six atopic and 20 normal children were studied. The atopic children consisted of 18 with allergic rhinitis (12 without sinusitis and 6 with sinusitis), and 28 children with rhinitis with asthma (13 with normal sinus radiographs and 15 with complete opacification of the maxillary sinuses). Methacholine PC20 was determined before and 30 days after treatment with nasal saline, sulfamethoxazole-trimethoprim, antihistamine/decongestant, and five days of prednisone. Sinus radiographs were also repeated.
  
  
  RESULTS
  The only patients with increase in methacholine PC20 were patients with rhinitis and asthma with opacified maxillary sinuses at entry and who at 30 days had normal sinus radiographs (P < .05).
  
  
  CONCLUSIONS
  In this study, children with allergic rhinitis and sinusitis with asthma improved their bronchial hyperresponsiveness to methacholine and decreased their symptoms with appropriate response of their sinuses to clinical therapy.
authors.affiliation: Department of Pediatrics, Federal University of São Paulo Escola Paulista de Medicina, Brazil.
authors.forename: C A
authors.initials: CA
authors.lastname: Oliveira
authors.forename: D
authors.initials: D
authors.lastname: Solé
authors.forename: C K
authors.initials: CK
authors.lastname: Naspitz
authors.forename: G S
authors.initials: GS
authors.lastname: Rachelefsky
mesh_terms: D000281:Administration, Intranasal; D000293:Adolescent; D000890:Anti-Infective Agents / Q000627:therapeutic use; D001249:Asthma / Q000150:complications / Q000503:physiopathology*; D016535:Bronchial Hyperreactivity / Q000503:physiopathology*; D001985:Bronchial Provocation Tests; D002648:Child; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D008297:Male; D016210:Methacholine Chloride / Q000494:pharmacology; D011239:Prednisolone / Q000008:administration & dosage; D012852:Sinusitis / Q000150:complications* / Q000188:drug therapy*; D012965:Sodium Chloride / Q000008:administration & dosage; D013420:Sulfamethoxazole / Q000627:therapeutic use; D014295:Trimethoprim / Q000627:therapeutic use
chemical_list: D000890:Anti-Infective Agents; D016210:Methacholine Chloride; D012965:Sodium Chloride; D011239:Prednisolone; D014295:Trimethoprim; D013420:Sulfamethoxazole