title: One bolus dose of gentamicin and early oral therapy versus cefotaxime and subsequent oral therapy in the treatment of febrile urinary tract infection.
abstract: The efficacy and safety of two different regimens for parenteral treatment of presumed severe febrile urinary tract infection were compared in a randomized study. One hundred fifty-eight patients were treated with either cefotaxime 2 g i.v. twice daily for at least two days followed by norfloxacin 400 mg twice daily orally or one bolus dose of gentamicin 3 mg/kg i.v. and norfloxacin from the start. Three patients randomized to cefotaxime died. Of the 101 patients with verified urinary tract infection, clinical response to assigned therapy was seen in 79% and 74%, respectively. There was no difference in fever duration between the two regimens. The results indicate that one bolus dose of gentamicin with early oral therapy is a safe and effective alternative to common parenteral regimens for empirical treatment of febrile urinary tract infection.
authors.affiliation: Department of Infectious Diseases, Orebro Medical Center Hospital, Sweden.
authors.forename: K
authors.initials: K
authors.lastname: Sundman
authors.forename: P
authors.initials: P
authors.lastname: Arneborn
authors.forename: L
authors.initials: L
authors.lastname: Blad
authors.forename: L
authors.initials: L
authors.lastname: Sjöberg
authors.forename: T
authors.initials: T
authors.lastname: Vikerfors
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002439:Cefotaxime / Q000009:adverse effects / Q000627:therapeutic use*; D004359:Drug Therapy, Combination / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D005334:Fever / Q000188:drug therapy; D005839:Gentamicins / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009643:Norfloxacin / Q000009:adverse effects / Q000627:therapeutic use*; D011446:Prospective Studies; D014552:Urinary Tract Infections / Q000188:drug therapy*
chemical_list: D005839:Gentamicins; D009643:Norfloxacin; D002439:Cefotaxime