title: Acute myeloblastic leukemia associated with trisomy 8 and translocation 8;21 in a child with Down syndrome.
abstract: The present study examined an 11-year-old girl with Down syndrome who suffered from acute myeloblastic leukemia (AML) preceded by preleukemic pancytopenia. Chromosomal analysis of leukemic cells revealed a chromosome change at t(8;21) and trisomy 8 associated with constitutional trisomy 21. Treatment with antineoplastic agents led to complete remission.
authors.affiliation: Second Department of Pediatrics, Ohashi Hospital Toho University School of Medicine, Tokyo, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Yamaguchi
authors.forename: H
authors.initials: H
authors.lastname: Fujii
authors.forename: H
authors.initials: H
authors.lastname: Kazama
authors.forename: K
authors.initials: K
authors.lastname: Iinuma
authors.forename: N
authors.initials: N
authors.lastname: Shinomiya
authors.forename: T
authors.initials: T
authors.lastname: Aoki
mesh_terms: D002648:Child; D002871:Chromosome Banding; D002891:Chromosomes, Human, Pair 21; D002898:Chromosomes, Human, Pair 8; D004314:Down Syndrome / Q000150:complications* / Q000235:genetics; D005260:Female; D006801:Humans; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000150:complications / Q000235:genetics*; D010198:Pancytopenia / Q000150:complications; D014178:Translocation, Genetic; D014314:Trisomy