title: Suppression of Francisella tularensis growth in the rat by co-infection with F. novicida.
abstract: We have previously shown that when cultured in vitro, peritoneal rat macrophages infected with Francisella novicida spontaneously release nitric oxide in sufficient quantities to inhibit bacterial growth. However, it is not known whether F. novicida can have a similar antimicrobial effect in vivo. Here we show that a co-infection of F. novicida with Francisella tularensis can suppress the number of F. tularensis cells in rat spleens by as much as 100-fold.
authors.affiliation: Department of Biochemistry and Microbiology, University of Victoria, B.C., Canada.
authors.forename: S C
authors.initials: SC
authors.lastname: Cowley
authors.forename: S V
authors.initials: SV
authors.lastname: Myltseva
authors.forename: F E
authors.initials: FE
authors.lastname: Nano
mesh_terms: D000818:Animals; D005260:Female; D005603:Francisella / Q000502:physiology*; D005604:Francisella tularensis / Q000254:growth & development*; D051381:Rats; D011917:Rats, Inbred Lew; D013154:Spleen / Q000382:microbiology; D014406:Tularemia / Q000382:microbiology*