title: Are immunological markers, social and personal resources, or a complaint-free state predictors of progression among HIV-infected patients?
abstract: Predictors of disease progression were studied in 89 asymptomatic HIV-infected patients who were prospectively evaluated for psychosocial variables and the development of clinical symptoms over a period of 2 years. The subjects were assessed for symptoms, laboratory measures, demographic variables, social and personal resources, mental status, alcohol, nicotine and drug use, sexual activity and risk behaviour, and sexually transmitted diseases. After 1 year, 17% of the patients had developed HIV-associated symptoms (symptomatic disease or AIDS), and after 2 years, 32% had developed symptoms or had died. In the multivariate analyses, the baseline CD4 count was the only significant predictor of disease progression during both observation periods. Psychosocial measures did not predict the progression of HIV infection.
authors.affiliation: Department of Medicine, University Hospital, Zurich, Switzerland.
authors.forename: E
authors.initials: E
authors.lastname: Eich-Höchli
authors.forename: M W
authors.initials: MW
authors.lastname: Niklowitz
authors.forename: R
authors.initials: R
authors.lastname: Lüthy
authors.forename: M
authors.initials: M
authors.lastname: Opravil
mesh_terms: D000223:Adaptation, Psychological; D000328:Adult; D015415:Biomarkers / Q000097:blood; D018791:CD4 Lymphocyte Count; D016009:Chi-Square Distribution; D016001:Confidence Intervals; D018450:Disease Progression; D005260:Female; D016655:HIV Core Protein p24 / Q000097:blood; D015658:HIV Infections / Q000097:blood / Q000276:immunology* / Q000523:psychology*; D006801:Humans; D016015:Logistic Models; D008297:Male; D016017:Odds Ratio; D011379:Prognosis; D011446:Prospective Studies; D012944:Social Support; D013557:Switzerland; D013997:Time Factors
chemical_list: D015415:Biomarkers; D016655:HIV Core Protein p24