Effect of tibolone on postmenopausal women with myomas.
OBJECTIVE
The aim of this study is to assess the effect of Tibolone (Livial) on uterine fibroids in postmenopausal women.


METHODS
This study included 40 naturally postmenopausal women with at least one uterine fibroid measuring > 20 mm. All of theme were scanned by transvaginal ultrasonography. Patients were randomized into two groups. Group A (n = 20) were treated with Tibolone 2.5 mg daily for 1 year and group B (n = 20) did not received therapy. The size of the uterine fibroids was reevaluated on the end of the treatment.


RESULTS
No statistically significant difference was found in the mean volume of fibroids before and after treatment with Tibolone. The administration of Tibolone resulted in an increase of fibroid volume in three patients, whereas it remained constant in the majority of the patients (70%) and decreased in three patients.


CONCLUSIONS
Our results suggest that treating menopausal symptoms with Tibolone does not affect preexisting asymptomatic uterine fibroids.
Gregoriou
O
O
2nd Department of Obstetrics and Gynecology, University of Athens, Areteion Hospital, Greece.
Vitoratos
N
N
Papadias
C
C
Konidaris
S
S
Costomenos
D
D
Chryssikopoulos
A
A
D045930:Anabolic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D015914:Estrogen Replacement Therapy / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007889:Leiomyoma / Q000000981:diagnostic imaging / Q000503:physiopathology*; D009652:Norpregnenes / Q000008:administration & dosage / Q000009:adverse effects*; D017698:Postmenopause / Q000187:drug effects / Q000502:physiology*; D014463:Ultrasonography; D014594:Uterine Neoplasms / Q000000981:diagnostic imaging / Q000503:physiopathology*
D045930:Anabolic Agents; D009652:Norpregnenes; C027385:tibolone