Investigation of [67Ga]dimethylgallium(III) acetylacetonate as a potential radiopharmaceutical.
Carrier-added [67Ga]dimethylgallium(III) acetylacetonate, a four coordinate Ga complex with two hydrolytically-stable Ga-C bonds, was prepared at a specific activity of 2.8 mCi/mmol. The biodistribution of this tracer was determined following intravenous injection into rats as a 5% ethanol: 19% propylene glycol solution in saline. Although the myocardial levels of 67Ga were fairly constant over a 2 h time period (%ID/heart = 0.80 +/- 0.19, 0.67 +/- 0.04 and 0.62 +/- 0.07 at 1.30 and 120 min post-injection, respectively), somewhat slow clearance of activity from the blood would preclude the use of this organometallic gallium complex as a myocardial imaging agent.
Coggin
D K
DK
Department of Medicinal Chemistry, School of Pharmacy, Purdue University, West Lafayette, IN 47907-1333, USA.
Mathias
C J
CJ
Green
M A
MA
D000818:Animals; D004912:Erythrocytes / Q000378:metabolism; D005710:Gallium Radioisotopes; D008657:Metabolic Clearance Rate; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D051381:Rats; D014018:Tissue Distribution
D005710:Gallium Radioisotopes; D019275:Radiopharmaceuticals