[The use of a method of estimating the count of viable Rickettsia prowazekii for the screening of efficacious antibiotics].
The possibility of the evaluation of antirickettsial activity of chemopreparations, both in vitro (by the inhibition of hemolytic activity) and in vivo (under the conditions of experimental pulmonary rickettsiosis in mice), with the use of the rapid method for the determination of the number of metabolically active rickettsiae is shown. The proposed approach may be used in the complex of mutually complementary methods for the screening of antirickettsial preparations.
Predtechenskiĭ
A B
AB
Filipenko
G N
GN
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000627:therapeutic use; D002642:Chick Embryo; D015169:Colony Count, Microbial / Q000379:methods; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D005260:Female; D006461:Hemolysis; D008297:Male; D051379:Mice; D008826:Microbial Sensitivity Tests / Q000379:methods; D012283:Rickettsia prowazekii / Q000187:drug effects* / Q000254:growth & development* / Q000472:pathogenicity; D013997:Time Factors; D014438:Typhus, Epidemic Louse-Borne / Q000188:drug therapy / Q000382:microbiology
D000900:Anti-Bacterial Agents
Ispol'zovanie metoda otsenki kolichestva zhiznesposobnykh Rickettsia prowazekii dlia skrininga éffektivnykh antibiotikov.