Influence of L-lysine and zinc administration during exposure to lead or lead and ethanol in rats.
Influence of lysine and zinc administration on the lead-sensitive biochemical parameters and the accumulation of lead during exposure to lead or lead and ethanol was investigated in rats. The lead exposure inhibited blood delta-aminolevulinic acid dehydratase (ALAD) activity, increased blood zinc protoporphyrin (ZPP), urinary delta-aminolevulinic acid (ALA), serum glutamic oxalacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT), blood and tissue lead levels, and decreased blood and hepatic glutathione (GSH) contents. Some of these effects were enhanced on coexposure to ethanol. The simultaneous administration of lysine and zinc reduced tissue accumulation of lead and most of the lead-induced biochemical alterations irrespective of exposure to lead alone or lead and ethanol. The depletion of endogenous calcium and magnesium owing to lead or ethanol exposure was also prevented by co-administration of lysine and zinc.
Tandon
S K
SK
Chemical Toxicology, Industrial Toxicology Research Centre, Lucknow, India.
Singh
S
S
Prasad
S
S
Mathur
N
N
D000410:Alanine Transaminase / Q000097:blood; D000704:Analysis of Variance; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D002118:Calcium / Q000378:metabolism; D004357:Drug Synergism; D000431:Ethanol / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism / Q000633:toxicity*; D005978:Glutathione / Q000378:metabolism; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D007854:Lead / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism / Q000633:toxicity*; D007855:Lead Poisoning / Q000188:drug therapy*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008239:Lysine / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D008274:Magnesium / Q000378:metabolism; D008297:Male; D000623:Porphobilinogen Synthase / Q000097:blood; D011524:Protoporphyrins / Q000097:blood; D051381:Rats; D012997:Solvents / Q000008:administration & dosage / Q000633:toxicity*; D013054:Spectrophotometry, Atomic; D014018:Tissue Distribution; D015032:Zinc / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*
D011524:Protoporphyrins; D012997:Solvents; C017803:zinc protoporphyrin; D007854:Lead; D000431:Ethanol; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000623:Porphobilinogen Synthase; D005978:Glutathione; D008274:Magnesium; D015032:Zinc; D008239:Lysine; D002118:Calcium