title: Nicotine patch and self-help video for cigarette smoking cessation.
abstract: A total of 424 smokers were randomized in a 2 x 2 factorial experiment. A pharmacologic factor contained 2 levels: transdermal nicotine path (TNP; 21 mg) and placebo. A self-help behavioral treatment factor contained 2 levels: video-enhanced self-help treatment manual and self-help treatment manual only. At 2 months, TNP produced a higher level of abstinence (36%) than placebo (20%), p < .001. No other comparison was significant. In secondary analyses, (at 2 months) and compliance with patch treatment regimen (at 2, 6, and 12 months) were associated with less relapse. Although nicotine replacement therapy has improved our ability to produce smoking cessation, the production of sustained, longer term abstinence remains an elusive goal.
authors.affiliation: Center for Research in Disease Prevention, Stanford University School of Medicine, Palo Alto, California 94304-1885, USA. Killen@SCRDP.Stanford.EDU
authors.forename: J D
authors.initials: JD
authors.lastname: Killen
authors.forename: S P
authors.initials: SP
authors.lastname: Fortmann
authors.forename: L
authors.initials: L
authors.lastname: Davis
authors.forename: A
authors.initials: A
authors.lastname: Varady
mesh_terms: D000279:Administration, Cutaneous; D000328:Adult; D016009:Chi-Square Distribution; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008370:Manuals as Topic; D008875:Middle Aged; D009538:Nicotine / Q000627:therapeutic use*; D018722:Nicotinic Agonists / Q000627:therapeutic use*; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012648:Self Care / Q000379:methods*; D016540:Smoking Cessation / Q000379:methods*; D016019:Survival Analysis; D016896:Treatment Outcome; D014741:Video Recording
chemical_list: D018722:Nicotinic Agonists; D009538:Nicotine