title: Sexually-transmitted disease (STD) markers in multitransfused children in relation to human immunodeficiency virus type-1 (HIV-1) infection: impact of STD markers in blood donors.
abstract: Association of serological markers for various sexually transmitted diseases (STDs) with Human Immunodeficiency Virus type 1 (HIV-1) infection among heterosexually promiscuous blood donors is well recognized. However, possibility of similar association among children receiving transfusion from these donors has not been adequately explored. Study on the association of some STD markers with HIV-1 infection in multitransfused (MT) children showed that both HIV-1 positive and HIV-1 negative groups of children had significantly higher prevalence of hepatitis B virus (HBV) markers, i.e. HBsAg (23 and 30 per cent), anti-HBs (46 and 57 per cent), anti-HBc (18 and 23 per cent), antibodies to cytomegalovirus of IgM class (36 and 37 per cent) and IgG class (72.7 and 70 per cent), IgG antibodies to Herpes Simplex Virus type-2 (23 and 23 per cent) compared to control group. However, seropositivity for HIV-1 infection could not be attributed as a risk factor for any of these markers in the group of MT children. On the contrary, significant association of anti HBc, anti HCV, CMV IgG and antitreponemal antibody with HIV-1 infection could be recorded in the group of blood donors. It appeared that due to low prevalence of HIV-1 infection among blood donors in India, both HIV-1 positive and HIV-1 negative groups of MT children received transfusion from HIV negative donors predominantly resulting in a comparable prevalence of STD markers in both the groups of MT children due to cumulative effect of transfusion from HIV-1 negative donors.
authors.affiliation: AIDS Reference Laboratory, National Institute of Communicable Diseases, Delhi, India.
authors.forename: D
authors.initials: D
authors.lastname: Chattopadhya
authors.forename: R
authors.initials: R
authors.lastname: Aggarwal
authors.forename: C
authors.initials: C
authors.lastname: Prakash
authors.forename: S
authors.initials: S
authors.lastname: Sen
authors.forename: S
authors.initials: S
authors.lastname: Kumari
mesh_terms: D015415:Biomarkers; D001782:Blood Donors / Q000706:statistics & numerical data*; D001803:Blood Transfusion / Q000706:statistics & numerical data*; D002648:Child; D004797:Enzyme-Linked Immunosorbent Assay; D015658:HIV Infections / Q000453:epidemiology / Q000276:immunology*; D018023:HIV Seronegativity / Q000276:immunology; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D007194:India / Q000453:epidemiology; D008297:Male; D012189:Retrospective Studies; D012749:Sexually Transmitted Diseases / Q000453:epidemiology / Q000276:immunology*; D065227:Transfusion Reaction; D014210:Treponema pallidum / Q000276:immunology
chemical_list: D015415:Biomarkers