Design, synthesis and use of binary encoded synthetic chemical libraries.
With the advent of combinatorial chemistry a new paradigm is evolving in the field of drug discovery. The approach is based on an integration of chemistry, high-throughput screening and automation engineering. The chemistry arm is usually based on solid-phase synthesis technology as the preferred approach to library construction. One of the most powerful of the solid-phase methods is encoded split synthesis, in which the reaction history experience by each polymeric bead is unambiguously recorded. This split-and-pool approach, employing chemically robust tags, was used to construct a 85,000-membered dihydrobenzopyran library.
Baldwin
J J
JJ
Pharmacopeia Inc., Princeton, NJ 08540, USA.
D001578:Benzopyrans / Q000138:chemical synthesis; D002257:Carbonic Anhydrase Inhibitors / Q000138:chemical synthesis; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D003432:Cross-Linking Reagents; D015195:Drug Design; D004364:Pharmaceutical Preparations / Q000138:chemical synthesis*; D012996:Solutions
D001578:Benzopyrans; D002257:Carbonic Anhydrase Inhibitors; D003432:Cross-Linking Reagents; D004364:Pharmaceutical Preparations; D012996:Solutions