Signalling enzymes: bursting with potential.
A newly identified form of phosphoinositide 3-kinase is regulated by G beta gamma subunits and is particularly abundant in phagocytic leukocytes. It is likely to be intimately involved in the process by which inflammatory signals regulate phagocyte activation and is a potential target for new anti-inflammatory drugs.
Braselmann
S
S
ONYX Pharmaceuticals, Richmond, California 94806, USA.
Palmer
T M
TM
Cook
S J
SJ
D000595:Amino Acid Sequence; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000494:pharmacology; D019204:GTP-Binding Proteins / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D010586:Phagocytes / Q000187:drug effects / Q000201:enzymology / Q000502:physiology; D019869:Phosphatidylinositol 3-Kinases; D017853:Phosphotransferases (Alcohol Group Acceptor) / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D020794:Receptor Protein-Tyrosine Kinases / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*
D000893:Anti-Inflammatory Agents; D004791:Enzyme Inhibitors; D019869:Phosphatidylinositol 3-Kinases; D017853:Phosphotransferases (Alcohol Group Acceptor); D020794:Receptor Protein-Tyrosine Kinases; D019204:GTP-Binding Proteins