Serologic evidence of Jamestown Canyon virus infection in white-tailed deer populations from Connecticut.
We determined the prevalence and distribution of Jamestown Canyon (JC) virus antibody in white-tailed deer (Odocoileus virginianus) populations in Connecticut, USA. Sera were collected from hunter-killed deer during 1993. Antibody to JC virus was detected by enzyme-linked immunosorbent assay (ELISA) in 92 (21%) of 446 deer sera, and was uniformly distributed among geographic sites. Twenty-one ELISA-positive sera were tested and confirmed positive by plaque reduction neutralization testing. This represents the first serologic evidence of JC virus in a reservoir host population from the northeastern United States. No cross-reactivity was seen with California encephalitis, Keystone, or snowshoe hare viruses, but a varying degree of cross-reactivity was obtained with Guaroa, Jerry Slough, La-Crosse, San Angelo, and trivittatus viruses. We conclude from this investigation and previous isolations of JC virus from mosquitoes in the state that JC virus occurs enzootically in Connecticut.
Zamparo
J M
JM
Yale Arbovirus Research Unit, Yale University School of Medicine, New Haven, Connecticut 06520, USA.
Andreadis
T G
TG
Shope
R E
RE
Tirrell
S J
SJ
D000818:Animals; D000914:Antibodies, Viral / Q000097:blood*; D003237:Connecticut / Q000453:epidemiology; D003429:Cross Reactions; D003670:Deer; D002141:Encephalitis Virus, California / Q000276:immunology*; D004670:Encephalitis, California / Q000453:epidemiology / Q000662:veterinary*; D004797:Enzyme-Linked Immunosorbent Assay / Q000662:veterinary; D015995:Prevalence; D016036:Seroepidemiologic Studies
D000914:Antibodies, Viral