title: Asymmetric angioneurotic edema associated with thrombolysis for acute stroke.
abstract: We present a case of acute asymmetric angioneurotic edema associated with the use of recombinant tissue plasminogen activator (rtPA) for acute ischemic stroke. rtPA was administered for an acute ischemic stroke in accordance with the recently reported National Institute of Neurological Disorders and Stroke protocol, after which marked asymmetric angioedema requiring upper-airway control developed. Although atypical and anaphylactoid reactions have been reported with the use of rtPA for acute myocardial infarction, to our knowledge this is the first case report of asymmetric angioedema associated with the use of rtPA for acute ischemic stroke.
authors.affiliation: Department of Emergency Medicine, University of Cincinnati College of Medicine, OH 45267-0769, USA. arthur.pancioli@oa.uc.edu
authors.forename: A
authors.initials: A
authors.lastname: Pancioli
authors.forename: T
authors.initials: T
authors.lastname: Brott
authors.forename: V
authors.initials: V
authors.lastname: Donaldson
authors.forename: R
authors.initials: R
authors.lastname: Miller
mesh_terms: D000208:Acute Disease; D000799:Angioedema / Q000139:chemically induced* / Q000503:physiopathology; D002561:Cerebrovascular Disorders / Q000188:drug therapy* / Q000503:physiopathology; D005260:Female; D006801:Humans; D008875:Middle Aged; D011994:Recombinant Proteins / Q000009:adverse effects; D015912:Thrombolytic Therapy / Q000009:adverse effects*; D010959:Tissue Plasminogen Activator / Q000009:adverse effects*
chemical_list: D011994:Recombinant Proteins; D010959:Tissue Plasminogen Activator