title: No association or linkage between the 5-HT2a/T102C polymorphism and schizophrenia in Irish families.
abstract: Recent findings of an association between schizophrenia and a T102C polymorphism at the 5-HT2a receptor gene (particularly with genotype 1-2 and 2-2 and allele 2) prompted us to investigate this marker in familial Irish schizophrenic patients, their relatives, and ethnically matched unrelated controls; 247 probands and 249 controls were included in this study. In contrast to some studies, we found no evidence of significant differences either in the frequency of the genotypes 1-2 and 2-2 or allele 2 between the schizophrenic patients and the controls. A transmission disequilibrium test, run on the full set of 265 families yielded no evidence to support linkage disequilibrium. Linkage analysis with both parametric and non-parametric methods yielded strongly negative results. Our findings are consistent with other recent association studies which argue against the involvement of the 5-HT2a/T102C polymorphism in predisposition to schizophrenia. The positive findings reported to date might have occurred by chance or the apparent conflict may be due to genetic heterogeneity between samples.
authors.affiliation: Department of Psychiatry, Trinity College, Dublin, Ireland.
authors.forename: Z
authors.initials: Z
authors.lastname: Hawi
authors.forename: M V
authors.initials: MV
authors.lastname: Myakishev
authors.forename: R E
authors.initials: RE
authors.lastname: Straub
authors.forename: A
authors.initials: A
authors.lastname: O'Neill
authors.forename: K S
authors.initials: KS
authors.lastname: Kendler
authors.forename: D
authors.initials: D
authors.lastname: Walsh
authors.forename: M
authors.initials: M
authors.lastname: Gill
mesh_terms: D004198:Disease Susceptibility; D005260:Female; D005838:Genotype; D006801:Humans; D007494:Ireland / Q000453:epidemiology; D015810:Linkage Disequilibrium; D008126:Lod Score; D008297:Male; D008957:Models, Genetic; D011110:Polymorphism, Genetic; D044402:Receptor, Serotonin, 5-HT2A; D011985:Receptors, Serotonin / Q000235:genetics*; D012559:Schizophrenia / Q000453:epidemiology / Q000208:ethnology / Q000235:genetics*
chemical_list: D044402:Receptor, Serotonin, 5-HT2A; D011985:Receptors, Serotonin