title: Columnar cell carcinoma of the thyroid.
abstract: A case of columnar cell carcinoma of the thyroid occurring in a 50-year-old female is described. Histologically, the 2 cm tumor showed a prominent papillary architecture with thin fibrous cores covered by columnar cells and marked nuclear stratification. It also showed microfollicular, glandular, and solid patterns. The nuclear features were different to those of conventional papillary carcinoma and similar to those of follicular tumors. The tumor was principally encapsulated with vascular and minimal capsular invasion. The tumor cells were positive for thyroglobulin. The tumor was DNA diploid with a low S phase traction as determined by flow cytometry. The patient had no lymph node or distant metastasis. The patient was well and without disease 9 months after surgery. The possibility that the neoplasm is one of poorly differentiated thyroid carcinomas rises.
authors.affiliation: First Department of Pathology, Jikei University School of Medicine, Tokyo, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Fukunaga
authors.forename: S
authors.initials: S
authors.lastname: Shinozaki
authors.forename: Y
authors.initials: Y
authors.lastname: Miyazawa
authors.forename: S
authors.initials: S
authors.lastname: Ushigome
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism; D005260:Female; D006801:Humans; D008875:Middle Aged; D009375:Neoplasms, Glandular and Epithelial / Q000473:pathology*; D011003:Ploidies; D013954:Thyroglobulin / Q000378:metabolism; D013964:Thyroid Neoplasms / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor; D013954:Thyroglobulin