Potentiometric and coulometric titration of 6-propyl-2-thiouracil.
A method for the determination of 6-propyl-2-thiouracil involving its reaction with iodine in an alkaline medium is presented. In volumetric titration with potentiometric end-point detection, the range of determination is 125-500 mumol (21-85 mg). In coulometric titration using biamperometric end-point detection, 0.5-5.0 mumol (0.085-0.85 mg) of 6-propyl-2-thiouracil was successfully determined. The RSD in all applied techniques was < 1%. The methods developed were applied to the determination of 6-propyl-2-thiouracil in tablets.
Ciesielski
W
W
Department of Instrumental Analysis, University of Lodź, Poland.
Zakrzewski
R
R
D013956:Antithyroid Agents / Q000032:analysis*; D004572:Electrolysis; D011199:Potentiometry / Q000379:methods; D011441:Propylthiouracil / Q000032:analysis*; D013607:Tablets
D013956:Antithyroid Agents; D013607:Tablets; D011441:Propylthiouracil