[Structural changes in the tissues of white rats after capsaicin administration].
Tissue structure of albino rat lung, skin and cornea changing after administration of capsaicin (neurotoxin isolated from red pepper) was studied using light and electron microscope. 5 mg/kg dose causes tissue swelling and microcirculatory bed reaction. 200 mg/kg dose leads to more significant dystrophic tissue alterations. Fibrosclerosis signs were found in certain cases. Microcirculatory disorders are proposed as the main reason for tissue structure alterations observed, although the mechanism of their development is still unclear.
Vorob'eva
N F
NF
Kniazev
G G
GG
Lazarev
V A
VA
Spiridonov
V K
VK
D000818:Animals; D002211:Capsaicin / Q000008:administration & dosage* / Q000633:toxicity; D003315:Cornea / Q000098:blood supply / Q000187:drug effects* / Q000648:ultrastructure; D004305:Dose-Response Relationship, Drug; D007274:Injections, Intraperitoneal; D008168:Lung / Q000098:blood supply / Q000187:drug effects* / Q000648:ultrastructure; D008833:Microcirculation / Q000187:drug effects / Q000648:ultrastructure; D008854:Microscopy, Electron; D051381:Rats; D012867:Skin / Q000098:blood supply / Q000187:drug effects* / Q000648:ultrastructure; D013268:Stimulation, Chemical
D002211:Capsaicin
Strukturnye izmeneniia tkaneĭ belykh krys posle vvedeniia kapsaitsina.