title: [Work of breathing in noninvasive proportional assist ventilation in patients with respiratory insufficiency].
abstract: BACKGROUND
  The aim of the present study was to evaluate if Proportional Assist Ventilation (PAV), when applied noninvasively via face mask, can reduce ventilatory effort in patients with respiratory failure. We present preliminary results of an ongoing study.
  
  
  METHODS
  In 5 patients with respiratory failure due to different underlying disorders (pulmonary fibrosis, bilateral diaphragm paralysis, COPD) we compared the transdiaphragmal pressure-time integral. PTdi (integral off Pdi dt) after 15 minutes of noninvasive PAV to the baseline values without ventilatory support.
  
  
  CONCLUSIONS
  Four patients showed reduction of PTdi to various extend. One patient who presented low diaphragmal activity at baseline due to diaphragmal paralysis showed a slight increase in PTdi during ventilation. Mean PTdi decreased by 26.7%. PaCO2 in the 5 patients showed no significant change after 15 minutes of ventilation, thus indicating that with noninvasive PAV patients can maintain constant ventilation with reduced effort.
authors.affiliation: Zentrum für Innere Medizin, Medizinische Poliklinik, Schlafmedizinisches Labor der der Philipps-Universität Marburg.
authors.forename: T
authors.initials: T
authors.lastname: Gutheil
authors.forename: W
authors.initials: W
authors.lastname: Pankow
authors.forename: H
authors.initials: H
authors.lastname: Becker
authors.forename: J
authors.initials: J
authors.lastname: Juhász
authors.forename: A
authors.initials: A
authors.lastname: Stammnitz
authors.forename: L
authors.initials: L
authors.lastname: Grote
authors.forename: J H
authors.initials: JH
authors.lastname: Peter
authors.forename: P
authors.initials: P
authors.lastname: von Wichert
mesh_terms: D000368:Aged; D000403:Airway Resistance / Q000502:physiology; D003964:Diaphragm / Q000503:physiopathology; D005260:Female; D006801:Humans; D007385:Intermittent Positive-Pressure Ventilation; D008173:Lung Diseases, Obstructive / Q000209:etiology / Q000503:physiopathology* / Q000628:therapy; D008176:Lung Volume Measurements; D008297:Male; D008875:Middle Aged; D012131:Respiratory Insufficiency / Q000209:etiology / Q000503:physiopathology* / Q000628:therapy; D015656:Respiratory Mechanics / Q000502:physiology*; D012133:Respiratory Paralysis / Q000209:etiology / Q000503:physiopathology / Q000628:therapy; D014939:Work of Breathing / Q000502:physiology*
vernacular_title: Atemanstrengung unter nichtinvasiver Proportional Assist Ventilation (PAV) bei Patienten mit respiratorischer Insuffizienz.