Apheresis therapy for prolonged red cell aplasia after major ABO-mismatched bone marrow transplantation.
Two cases of leukemia were treated successfully with apheresis for delayed recovery of erythropoiesis due to antibody-mediated red cell aplasia after ABO-mismatched bone marrow transplantation (BMT). A 25-year-old female (ABO group O) underwent BMT from her brother (group A). Immunoadsorption using Biosynsorb A performed on day 146 after BMT followed by double filtration plasma pheresis (DFPP) reduced anti-A antibody titers from 1:32 to 1:2. Anemia improved dramatically within 2 weeks. A 49-year-old female (group O) underwent BMT from her mother (group A). She was treated with DFPP on day 131 after BMT. Anti-A antibody titers dropped from 1:16 to 1:1 and anemia improved gradually.
Ohta
S
S
Third Department of Internal Medicine, Kanazawa University, Ishikawa.
Yokoyama
H
H
Ise
T
T
Takasawa
K
K
Wada
T
T
Nakao
S
S
Matsuda
T
T
Kobayashi
K
K
D000017:ABO Blood-Group System / Q000276:immunology*; D000328:Adult; D001787:Blood Group Incompatibility / Q000150:complications*; D016026:Bone Marrow Transplantation / Q000009:adverse effects* / Q000276:immunology; D005260:Female; D006789:Host vs Graft Reaction / Q000276:immunology*; D006801:Humans; D007163:Immunosorbent Techniques; D007518:Isoantibodies / Q000276:immunology*; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000628:therapy; D015470:Leukemia, Myeloid, Acute / Q000628:therapy; D008297:Male; D008875:Middle Aged; D010956:Plasmapheresis; D012010:Red-Cell Aplasia, Pure / Q000209:etiology / Q000276:immunology / Q000628:therapy*; D014184:Transplantation, Homologous
D000017:ABO Blood-Group System; D007518:Isoantibodies