title: The complete genome sequence of the gastric pathogen Helicobacter pylori.
abstract: Helicobacter pylori, strain 26695, has a circular genome of 1,667,867 base pairs and 1,590 predicted coding sequences. Sequence analysis indicates that H. pylori has well-developed systems for motility, for scavenging iron, and for DNA restriction and modification. Many putative adhesins, lipoproteins and other outer membrane proteins were identified, underscoring the potential complexity of host-pathogen interaction. Based on the large number of sequence-related genes encoding outer membrane proteins and the presence of homopolymeric tracts and dinucleotide repeats in coding sequences, H. pylori, like several other mucosal pathogens, probably uses recombination and slipped-strand mispairing within repeats as mechanisms for antigenic variation and adaptive evolution. Consistent with its restricted niche, H. pylori has a few regulatory networks, and a limited metabolic repertoire and biosynthetic capacity. Its survival in acid conditions depends, in part, on its ability to establish a positive inside-membrane potential in low pH.
authors.affiliation: Institute for Genomic Research, Rockville, Maryland 20850, USA. ghp@tigr.org
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mesh_terms: D000940:Antigenic Variation; D001422:Bacterial Adhesion; D001426:Bacterial Proteins / Q000378:metabolism; D001483:Base Sequence; D005075:Biological Evolution; D002455:Cell Division; D004260:DNA Repair; D004269:DNA, Bacterial / Q000235:genetics; D015964:Gene Expression Regulation, Bacterial; D016680:Genome, Bacterial; D016480:Helicobacter pylori / Q000235:genetics* / Q000378:metabolism / Q000472:pathogenicity; D006863:Hydrogen-Ion Concentration; D008969:Molecular Sequence Data; D014176:Protein Biosynthesis; D011995:Recombination, Genetic; D014158:Transcription, Genetic; D014774:Virulence
chemical_list: D001426:Bacterial Proteins; D004269:DNA, Bacterial