title: Dynamic MRI of the gallbladder lesions: differentiation of benign from malignant.
abstract: Forty-nine pathologically proven gallbladder lesions were evaluated in 45 patients using dynamic MRI with a spoiled gradient pulse sequence (SPGR), to access the ability of this technique to differentiate benign from malignant gallbladder lesions. The studies were reviewed retrospectively. Signal intensity of the lesions were measured. Twenty-one malignant and 28 benign lesions were classified into three categories: polypoid, diffuse wall thickening, and exophytic. Early and delayed enhancement patterns were evaluated. For the polypoid masses, malignant lesions (n = 9) demonstrated early and prolonged enhancements, whereas benign lesions (n = 14) had early enhancement with subsequent washout (P < .05). For diffuse gallbladder wall thickening, malignant lesions (n = 6) demonstrated early and prolonged enhancement and benign lesions (n = 14) showed relatively slow, prolonged enhancement (P < .05). The exophytic masses (n = 6) all were malignant and demonstrated early and prolonged enhancement. Dynamic MRI can help differentiate benign from malignant gallbladder lesions.
authors.affiliation: Department of Radiology, Kyushu University Hospital, Higashi-ku Fukuoka, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Yoshimitsu
authors.forename: H
authors.initials: H
authors.lastname: Honda
authors.forename: K
authors.initials: K
authors.lastname: Kaneko
authors.forename: T
authors.initials: T
authors.lastname: Kuroiwa
authors.forename: H
authors.initials: H
authors.lastname: Irie
authors.forename: T
authors.initials: T
authors.lastname: Ueki
authors.forename: K
authors.initials: K
authors.lastname: Chijiiwa
authors.forename: K
authors.initials: K
authors.lastname: Takenaka
authors.forename: K
authors.initials: K
authors.lastname: Masuda
mesh_terms: D000328:Adult; D000368:Aged; D003937:Diagnosis, Differential; D005260:Female; D005704:Gallbladder / Q000473:pathology*; D005705:Gallbladder Diseases / Q000175:diagnosis*; D005706:Gallbladder Neoplasms / Q000175:diagnosis*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013997:Time Factors