Involvement of nitric oxide in 2-deoxy-D-glucose-induced hyperphagia in rats.
The effects of a nitric oxide (NO) synthase inhibitor NG-nitro-L-arginine methyl ester (L-NAME) on 2-deoxy-D-glucose (2-DG)-induced hyperphagia were investigated in rats. L-NAME dose-dependently inhibited 2-DG-induced eating in non-food-deprived rats, although the inactive isomer D-NAME on 2-DG-induced hyperphagia were inhibited by co-administration of L-arginine. The neuronal NO synthase inhibitor 7-nitroindazole also inhibited 2-DG-induced hyperphagia. These results suggest that 2-DG-induced hyperphagia is linked with NO and that brain NO may participate in this hyperphagic model.
Yamada
J
J
Department of Pharmacology, Kobe Pharmaceutical University, Japan.
Sugimoto
Y
Y
Yoshikawa
T
T
Horisaka
K
K
D000818:Animals; D003847:Deoxyglucose / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000494:pharmacology; D006963:Hyperphagia / Q000139:chemically induced*; D007191:Indazoles / Q000494:pharmacology; D008297:Male; D019331:NG-Nitroarginine Methyl Ester / Q000494:pharmacology*; D009569:Nitric Oxide / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013237:Stereoisomerism
D004791:Enzyme Inhibitors; D007191:Indazoles; D009569:Nitric Oxide; D003847:Deoxyglucose; C080122:7-nitroindazole; D019331:NG-Nitroarginine Methyl Ester