Neuregulin and erbB receptors play a critical role in neuronal migration.
The migration of neuronal precursors along radial glial fibers is a critical step in the formation of the nervous system. In this report, we show that neuregulin-erbB receptor signaling plays a crucial role in the migration of cerebellar granule cells along radial glial fibers. Granule cells express neuregulin (NRG), and radial glia cells express erbB4 in the developing cerebellum and in vitro. When the glial erbB receptors are blocked, neurons fail to induce radial glia formation, and their migration along radial glial fibers is impaired. Moreover, soluble NRG is as effective as neuron-glia contact in the induction of radial glia formation. These results suggest that the activation of glial erbB4 by NRG is an early critical step in the neuronal migration program.
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Department of Neurology, Children's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.
Rieff
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HI
Qi
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Khurana
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TS
Corfas
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G
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002465:Cell Movement / Q000187:drug effects*; D002478:Cells, Cultured; D002531:Cerebellum / Q000187:drug effects*; D006023:Glycoproteins / Q000494:pharmacology*; D020880:Neuregulins; D009457:Neuroglia / Q000187:drug effects; D009474:Neurons / Q000187:drug effects*; D011518:Proto-Oncogene Proteins / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley
D000970:Antineoplastic Agents; D006023:Glycoproteins; D020880:Neuregulins; D011518:Proto-Oncogene Proteins