Transfusion of platelet-rich plasma from the organ donor during cardiac transplantation.
OBJECTIVE
To evaluate whether transfusion of platelet-rich plasma from the organ donor during cardiac transplantation can influence the amount of the needed homologous blood products.


METHODS
Randomized, controlled study.


METHODS
University hospital.


METHODS
16 ASA physical status III patients undergoing orthotopic cardiac transplantation.


METHODS
Eight patients received donor plasma, while another 8 patients served as a control group. Blood from the organ donor was acquired during cardiac explantation. Thereafter platelet-rich plasma was separated by plasmapheresis (2400 turns per minute). The plasma was then transfused to the organ recipient at the end of the cardiac transplantation. The control group received a similar amount of albumin 5%.


RESULTS
In the patients who received donor plasma, the platelet count increased significantly from 98,000 +/- 49,000 mm-3 to 123,000 +/- 55,000 mm-3, the postoperative requirement of packed red blood cells (PRBCs) was 5.8 +/- 4.5 units, which was significantly lower as compared to the control group (10.8 +/- 5.9 units).


CONCLUSIONS
Transfusion of platelet-rich plasma from the organ donor to the recipient was confirmed to be feasible, the number of postoperatively transfused PRBCs was reduced.
Tassani
P
P
Institute of Anesthesiology, Grosshadern Medical Center, Ludwig-Maximilians-University, Munich, Germany.
Otto
D
D
Székely
A
A
Meiser
B
B
Uberfuhr
P
P
Pfeiffer
M
M
Jäenicke
U
U
D001803:Blood Transfusion; D005260:Female; D005858:Germany / Q000453:epidemiology; D006084:Graft Rejection / Q000453:epidemiology*; D016027:Heart Transplantation; D006801:Humans; D015994:Incidence; D008297:Male; D010976:Platelet Count; D011446:Prospective Studies; D012189:Retrospective Studies; D014019:Tissue Donors