title: Asterlingulatosides C and D, cytotoxic triterpenoid saponins from Aster lingulatus.
abstract: A further investigation of Aster lingulatus has led to the isolation of two additional novel triterpene saponins, asterlingulatoside C [3-O-beta-D-glucopyranosyl-3 beta, 16 alpha-dihydroxyolean-12-en-28-oic acid 28-O-beta-D-xylopyranosyl-(1-->4)-alpha-L-rhamnopyranosyl-(1-->2)-alpha- L- arabinopyranoside] (1) and asterlingulatoside D [3-O-beta-D-glucopyranosyl-3 beta,16 alpha-dihydroxyolean-12-en-28-oic acid 28-O-beta-D-xylopyranosyl-(1-->3)-beta-D-xylopyranosyl-(1-->4)-alpha-L- rhamnopyranosyl-(1-->2)-alpha-L-arabinopyranoside] (2). Elucidation of the structures of 1 and 2 was mainly based on FABMS and 1D and 2D homonuclear and heteronuclear NMR techniques. Compounds 1 and 2 showed good inhibitory activity against DNA synthesis in human leukemia HL-60 cells with IC50 values of 8.8 and 6.1 microM, respectively.
authors.affiliation: Department of Plant Science, Cook College, Rutgers, State University of New Jersey, New Brunswich 08903, USA.
authors.forename: Y
authors.initials: Y
authors.lastname: Shao
authors.forename: C T
authors.initials: CT
authors.lastname: Ho
authors.forename: C K
authors.initials: CK
authors.lastname: Chin
authors.forename: O
authors.initials: O
authors.lastname: Poobrasert
authors.forename: S W
authors.initials: SW
authors.lastname: Yang
authors.forename: G A
authors.initials: GA
authors.lastname: Cordell
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D018922:HL-60 Cells; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D009828:Oleanolic Acid / Q000031:analogs & derivatives*; D010946:Plants, Medicinal / Q000737:chemistry*; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013329:Structure-Activity Relationship
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D012503:Saponins; C107722:asterlingulatoside C; C107723:asterlingulatoside D; D009828:Oleanolic Acid