Acute renal failure in a patient receiving treatment with suramin.
Suramin has demonstrated modest activity against prostate cancer and is being investigated in clinical trials. We describe a patient with metastatic prostate cancer who developed nonoliguric renal failure during treatment with suramin. Other potential causes of renal failure were not present in our patient and his renal function gradually recovered with the cessation of suramin treatment. Acute renal failure should be recognized as a potential complication of suramin treatment.
Smith
A
A
University of New Mexico Cancer Research and Treatment Center, Albuquerque 87131, USA.
Harbour
D
D
Liebmann
J
J
D058186:Acute Kidney Injury / Q000139:chemically induced*; D000230:Adenocarcinoma / Q000188:drug therapy / Q000556:secondary*; D000726:Androgen Antagonists / Q000008:administration & dosage; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D018931:Antineoplastic Agents, Hormonal / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D005485:Flutamide / Q000008:administration & dosage; D006801:Humans; D006854:Hydrocortisone / Q000008:administration & dosage; D016729:Leuprolide / Q000008:administration & dosage; D008159:Lumbar Vertebrae; D008297:Male; D008875:Middle Aged; D011471:Prostatic Neoplasms / Q000473:pathology*; D012447:Sacrum; D013125:Spinal Neoplasms / Q000188:drug therapy / Q000556:secondary*; D013498:Suramin / Q000008:administration & dosage / Q000009:adverse effects*; D013904:Thoracic Vertebrae
D000726:Androgen Antagonists; D000893:Anti-Inflammatory Agents; D000970:Antineoplastic Agents; D018931:Antineoplastic Agents, Hormonal; D013498:Suramin; D005485:Flutamide; D016729:Leuprolide; D006854:Hydrocortisone