Studies of the role of the brain cholinergic system in the mechanisms of dissociative learning.
Rats were trained to make conditioned food reflex excursions in two states: in normal conditions and on a background of treatment with pharmacological agents producing dissociative states. A number of cholinergic substances were completely interchangeable in dissociative learning; anticholinergic compounds efficiently neutralized the ability of cholinergic substances to produce dissociative states; muscarinic cholinoreceptors played the leading role in production of the dissociative state.
Azarashvili
A A
AA
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino.
D000818:Animals; D001921:Brain / Q000502:physiology*; D002219:Carbamates; D018680:Cholinergic Antagonists / Q000494:pharmacology; D002800:Cholinesterase Inhibitors / Q000494:pharmacology; D003214:Conditioning, Classical / Q000187:drug effects / Q000502:physiology*; D004347:Drug Interactions; D005247:Feeding Behavior / Q000187:drug effects / Q000502:physiology*; D005702:Galantamine / Q000494:pharmacology; D008297:Male; D010830:Physostigmine / Q000494:pharmacology; D011725:Pyridines; D011729:Pyridostigmine Bromide / Q000031:analogs & derivatives; D051381:Rats; D017208:Rats, Wistar; D011950:Receptors, Cholinergic / Q000187:drug effects / Q000502:physiology*; D011976:Receptors, Muscarinic / Q000187:drug effects / Q000502:physiology; D011978:Receptors, Nicotinic / Q000187:drug effects / Q000502:physiology
D002219:Carbamates; D018680:Cholinergic Antagonists; D002800:Cholinesterase Inhibitors; D011725:Pyridines; D011950:Receptors, Cholinergic; D011976:Receptors, Muscarinic; D011978:Receptors, Nicotinic; D005702:Galantamine; C070102:aminostigmine; D010830:Physostigmine; D011729:Pyridostigmine Bromide