[The effect of the liposomal form of hydrocortisone on the status of cellular and humoral immunity in patients with steroid-dependent bronchial asthma].
The authors present the results of treatment of 78 patients with steroid-dependent bronchial asthma. The most noticeable effect was observed in the patients on combined therapy including impulse irrigation of the bronchi (during sparing fiber bronchoscopy) with liposome and hydrocortisone as compared to the controls receiving this procedure with liposome without hydrocortisone, and a group of patients who had received systemic corticosteroids by a routine method. In the attack period inhibition of both cellular and humoral immunity was observed in all the examinees with steroid-dependent bronchial asthma who had received systemic corticosteroids. A positive therapeutic effect consisting in elimination of inflammation in the tracheobronchial tree and normalizing the indices of cellular and humoral immunity was observed earlier in patients receiving therapeutic fiber bronchoscopy with liposome and hydrocortisone. The efficacy of the use of impulse irrigation of the bronchi with liposome in steroid-dependent bronchial asthma was emphasized.
Prishchepa
I V
IV
Landyshev
Iu S
IuS
D000293:Adolescent; D000328:Adult; D018927:Anti-Asthmatic Agents / Q000008:administration & dosage*; D000917:Antibody Formation / Q000187:drug effects; D001249:Asthma / Q000188:drug therapy* / Q000276:immunology; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000008:administration & dosage*; D007111:Immunity, Cellular / Q000187:drug effects; D008081:Liposomes; D008297:Male; D008875:Middle Aged
D018927:Anti-Asthmatic Agents; D008081:Liposomes; D006854:Hydrocortisone
Vliianie liposomnoĭ formy gidrokortizona na sostoianie kletochnogo i gumoral'nogo immuniteta u bol'nykh steroidzavisimoĭ bronkhial'noĭ astmoĭ.