[Aplastic anemia. Alternative treatment by bone marrow transplantation].
We report a case of a 25-year-old woman, with the diagnosis of severe aplastic anemia without a histocompatible sibling donor for bone marrow transplantation. The patient has been treated successfully with a combination of two immunosuppressive agents, cyclosporine and antilymphocyte globulin, after not responding to primary therapy with corticosteroids and growth factors. She showed a complete response to treatment, with transfusional independence, after a follow-up of 14 months. The pathophysiology of aplastic anemia, the mechanism of action and secondary effects of these treatments are discussed.
Fonseca
T
T
Serviço Medicina I, Hospital de Santa maria, Lisboa.
Raposo
J
J
Gomez
B
B
d'Oliveira
J J
JJ
de Lacerda
J M
JM
D000328:Adult; D000741:Anemia, Aplastic / Q000175:diagnosis / Q000628:therapy*; D001706:Biopsy; D016026:Bone Marrow Transplantation; D001842:Bone and Bones / Q000473:pathology; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007165:Immunosuppression Therapy
Anemia aplástica. Tratamento alternativo à transplantação medular.