title: Marked improvement of severe polyneuropathy associated with multifocal osteosclerotic myeloma following surgery, radiation, and chemotherapy.
abstract: We describe a patient with a 3 year history of progressive polyneuropathy that rendered him severely quadriparetic and bedridden. Work up revealed an IgG lambda monoclonal spike and multifocal osteosclerotic myeloma. Remarkable improvement followed combined treatment with surgical excision, radiation therapy, and chemotherapy using chlorambucil, danazol, and hydrocortisone. Hence, we believe that aggressive local therapy associated with systemic chemotherapy should be considered in severely affected patients with multifocal osteosclerotic myeloma and peripheral neuropathy.
authors.affiliation: Department of Neurology, University of Miami School of Medicine, Florida 33101, USA.
authors.forename: F T
authors.initials: FT
authors.lastname: Rotta
authors.forename: W G
authors.initials: WG
authors.lastname: Bradley
mesh_terms: D000328:Adult; D006801:Humans; D006811:Humerus / Q000000981:diagnostic imaging; D008297:Male; D009101:Multiple Myeloma / Q000150:complications* / Q000188:drug therapy / Q000532:radiotherapy; D010026:Osteosclerosis / Q000150:complications* / Q000188:drug therapy / Q000532:radiotherapy; D016878:POEMS Syndrome / Q000150:complications* / Q000188:drug therapy / Q000532:radiotherapy; D010808:Physical Examination; D010956:Plasmapheresis; D011115:Polyneuropathies / Q000150:complications* / Q000601:surgery; D011859:Radiography