Influence of moderate haemodilution with fluosol or normal saline on carbaryl disposition in Sprague-Dawley rats.
In rats carbaryl undergoes extensive biotransformation involving both albumin-mediated hydrolysis and cytochrome P-450-mediated metabolism; studies have suggested that approximately one-half of a carbaryl dose is hydrolysed and one-half is metabolized. Fluosol is known to be an inducer of cytochrome P-450, and Fluosol haemodilution reduces plasma albumin concentrations. The disposition of carbaryl was, therefore, determined in rats for 72 h after 40 mL kg-1 haemodilution with Fluosol or normal saline (0.9% NaCl). Volumes of distribution were significantly reduced after saline haemodilution for 72 h but only at 48 h after Fluosol haemodilution. Fluosol and saline haemodilution had little influence on carbaryl total body clearance (CL). These results indicate that both hepatic and non-hepatic clearance pathways were not influenced by the haemodiluents or the haemodilution procedure.
Shrewsbury
R P
RP
School of Pharmacy, University of North Carolina at Chapel Hill 27599-7360, USA.
Johnson
L W
LW
Oliver
S R
SR
D000818:Animals; D001711:Biotransformation; D001802:Blood Substitutes / Q000494:pharmacology*; D012721:Carbaryl / Q000493:pharmacokinetics*; D005466:Fluorocarbons / Q000494:pharmacology*; D006438:Hemodilution; D007306:Insecticides / Q000493:pharmacokinetics*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012965:Sodium Chloride / Q000494:pharmacology*
D001802:Blood Substitutes; D005466:Fluorocarbons; D007306:Insecticides; D012965:Sodium Chloride; C050455:fluosol; D012721:Carbaryl