Heritable factors distinguish two types of alopecia areata.
Alopecia areata (AA) has been shown to be associated with the inheritance of HLA class II alleles. HLA-DQ3 appears to be the general susceptibility allele for AA. Patients with long-standing disease patterns, namely, longterm patchy AA and long-term alopecia totalis and alopecia universalis (AT/AU), can be differentiated by their particular HLA associations. Long-standing AT/AU patients have unique and highly significant associations with HLA antigens DR4, DR11, and DQ7. A complex of early onset, disease severity, family incidence, and associations with HLA DR antigens are characteristic of long-standing AT/AU as distinct from long-standing patchy AA.
Price
V H
VH
Department of Dermatology, University of California, USA.
Colombe
B W
BW
D000328:Adult; D017668:Age of Onset; D000505:Alopecia / Q000145:classification* / Q000453:epidemiology / Q000235:genetics*; D001327:Autoimmune Diseases / Q000235:genetics* / Q000276:immunology; D001788:Blood Grouping and Crossmatching; D002648:Child; D004247:DNA / Q000032:analysis; D008040:Genetic Linkage; D006680:HLA Antigens / Q000235:genetics*; D000949:Histocompatibility Antigens Class II / Q000145:classification; D006801:Humans; D015995:Prevalence; D012307:Risk Factors
D006680:HLA Antigens; D000949:Histocompatibility Antigens Class II; D004247:DNA