title: Continuous plasma resin perfusion for detoxification of methotrexate.
abstract: Acute renal failure is a rare but very severe side-effect of methotrexate (MTX) treatment requiring extracorporeal detoxification. A new detoxification regime, consisting of a haemodiafiltration (HDF) and continuous plasma resin perfusion (PRP) over anion exchange resin column with high affinity for MTX, was used for treatment of MTX-induced acute renal failure in a 2-year-old boy with medulloblastoma. More than 99% of MTX was removed from plasma by perfusion over the resin column resulting in a marked decrease of MTX plasma half-life. No haematological complications occurred.
  
  
  CONCLUSIONS
  The use of PRP alone or in combination with HDF is a new and effective treatment strategy for extracorporeal detoxification of MTX.
authors.affiliation: Klinik mit Poliklinik für Kinder und Jugendliche, University of Erlangen-Nürnberg, Germany.
authors.forename: J
authors.initials: J
authors.lastname: Greil
authors.forename: P A
authors.initials: PA
authors.lastname: Wyss
authors.forename: K
authors.initials: K
authors.lastname: Ludwig
authors.forename: S
authors.initials: S
authors.lastname: Bonakdar
authors.forename: J
authors.initials: J
authors.lastname: Scharf
authors.forename: J D
authors.initials: JD
authors.lastname: Beck
authors.forename: H
authors.initials: H
authors.lastname: Ruder
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000628:therapy; D000964:Antimetabolites, Antineoplastic / Q000009:adverse effects* / Q000493:pharmacokinetics; D002675:Child, Preschool; D017583:Hemodiafiltration; D006801:Humans; D007475:Ion Exchange Resins; D008297:Male; D008657:Metabolic Clearance Rate; D008727:Methotrexate / Q000009:adverse effects* / Q000493:pharmacokinetics; D016060:Sorption Detoxification / Q000379:methods*
chemical_list: D000964:Antimetabolites, Antineoplastic; D007475:Ion Exchange Resins; D008727:Methotrexate