title: Clinical comparison of radiolocalization of two monoclonal antibodies (mAbs) against the TAG-72 antigen.
abstract: Ten patients with colorectal cancer metastases received 125I-B72.3 and 131I-CC49 prior to laparotomy (five patients received 1 mg, and five 20 mg of each mAb). Tumor:serum ratios of 131I-CC49 were better than those of 125I-B72.3 (P < 0.01 at 1 mg; P = 0.05 at 20 mg; P < 0.01 at both doses). All known lesions > or = 1 cm in diameter were visualized at the 20 mg dose. There was no difference in absolute tumor uptake of 125I-B72.3 or 131I-CC49. We conclude that mAb CC49 has better relative uptake in colorectal cancers than mAb B72.3.
authors.affiliation: Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.
authors.forename: C R
authors.initials: CR
authors.lastname: Divgi
authors.forename: A M
authors.initials: AM
authors.lastname: Scott
authors.forename: K
authors.initials: K
authors.lastname: McDermott
authors.forename: P S
authors.initials: PS
authors.lastname: Fallone
authors.forename: S
authors.initials: S
authors.lastname: Hilton
authors.forename: K
authors.initials: K
authors.lastname: Siler
authors.forename: N
authors.initials: N
authors.lastname: Carmichael
authors.forename: F
authors.initials: F
authors.lastname: Daghighian
authors.forename: R D
authors.initials: RD
authors.lastname: Finn
authors.forename: A M
authors.initials: AM
authors.lastname: Cohen
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary; D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal / Q000493:pharmacokinetics / Q000627:therapeutic use*; D000951:Antigens, Neoplasm / Q000276:immunology*; D015179:Colorectal Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000532:radiotherapy*; D005260:Female; D006023:Glycoproteins / Q000276:immunology*; D006801:Humans; D018796:Immunoconjugates / Q000493:pharmacokinetics / Q000627:therapeutic use*; D007457:Iodine Radioisotopes / Q000493:pharmacokinetics / Q000627:therapeutic use*; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary; D008297:Male; D008875:Middle Aged; D010386:Pelvic Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary; D016499:Radioimmunotherapy; D012008:Recurrence; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm; D006023:Glycoproteins; D018796:Immunoconjugates; D007457:Iodine Radioisotopes; C047052:tumor-associated antigen 72