title: Inhibitory effects of shouseiryu-to on two-stage carcinogenesis. II. Anti-tumor-promoting activities of lignans from Asiasarum heterotropoides var. mandshuricum.
abstract: Two lignans, asarinin (6) and xanthoxylol (7), were isolated from the radix of Asiasarum heterotropoides var. mandshuricum, which consist of a kampo prescription, Shouseiryu-to, as inhibitors of Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA). These lignans also exhibited remarkable inhibitory effects on a two-stage carcinogenesis test of mouse skin and pulmonary tumors. Furthermore, it was confirmed that these hydrophobic lignans dissolved in the water decoction of Shouseiryu-to, and these lignans might be among the active constituents of this kampo prescription in terms of its anti-tumor-promoting activity.
authors.affiliation: Kyoto Pharmaceutical University, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Takasaki
authors.forename: T
authors.initials: T
authors.lastname: Konoshima
authors.forename: I
authors.initials: I
authors.lastname: Yasuda
authors.forename: T
authors.initials: T
authors.lastname: Hamano
authors.forename: H
authors.initials: H
authors.lastname: Tokuda
mesh_terms: D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D000956:Antigens, Viral / Q000235:genetics; D002460:Cell Line; D002471:Cell Transformation, Neoplastic / Q000187:drug effects* / Q000235:genetics; D004149:Dioxoles / Q000494:pharmacology*; D005260:Female; D005663:Furans / Q000494:pharmacology*; D017705:Lignans; D008175:Lung Neoplasms / Q000517:prevention & control; D051379:Mice; D008813:Mice, Inbred ICR; D010636:Phenols / Q000494:pharmacology*; D012878:Skin Neoplasms / Q000517:prevention & control; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology
chemical_list: D016588:Anticarcinogenic Agents; D000956:Antigens, Viral; D004149:Dioxoles; C033305:Epstein-Barr virus early antigen; D005663:Furans; D017705:Lignans; D010636:Phenols; C108246:xanthoxylol; D013755:Tetradecanoylphorbol Acetate; C054125:sesamin