1H-NMR analysis of trimethylamine in urine for the diagnosis of fish-odour syndrome.
This paper reports the use of proton NMR spectroscopy for the analysis of trimethylamine in the urine of a patient with trimethylaminuria. Analysis of this compound was also performed for other members of his family. Qualitative and quantitative determination of trimethylamine and trimethylamine-N-oxide was simultaneously performed on untreated urine within a few minutes. The application of the method is discussed.
Maschke
S
S
Laboratoire de Biochimie, Hôpital Calmette, CHR et U de Lille, France.
Wahl
A
A
Azaroual
N
N
Boulet
O
O
Crunelle
V
V
Imbenotte
M
M
Foulard
M
M
Vermeersch
G
G
Lhermitte
M
M
D006631:Amine Oxidase (Copper-Containing); D005260:Female; D006801:Humans; D008099:Liver / Q000201:enzymology; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D008661:Metabolism, Inborn Errors / Q000175:diagnosis / Q000235:genetics / Q000652:urine*; D008744:Methylamines / Q000652:urine*; D009812:Odorants; D010084:Oxidation-Reduction; D000587:Oxidoreductases Acting on CH-NH Group Donors / Q000172:deficiency; D011522:Protons
D008744:Methylamines; D011522:Protons; D006631:Amine Oxidase (Copper-Containing); D000587:Oxidoreductases Acting on CH-NH Group Donors; C005855:trimethyloxamine; C023336:trimethylamine