title: Assessment of local brain activation. A simultaneous PET and near-infrared spectroscopy study.
abstract: In five healthy human subjects, near-infrared spectroscopy (NIRS) and positron emission tomography (PET) examinations were performed simultaneously. Changes in [oxy-Hb], [deoxy-Hb] and [total-Hb] as measured by NIRS over the left forehead were compared to measurements of cerebral blood flow by PET during rest and during performance of a calculation task and a Stroop task. When a penetration depth of near-infrared light 0.9 cm into the brain cortex was assumed, a statistically significant correlation between changes in CBF and changes in [total-Hb] was found. These data confirm the validity of NIRS measurements in human adults.
authors.affiliation: Department of Radiology, Benjamin-Franklin Hospital, Berlin, Germany.
authors.forename: K
authors.initials: K
authors.lastname: Villringer
authors.forename: S
authors.initials: S
authors.lastname: Minoshima
authors.forename: C
authors.initials: C
authors.lastname: Hock
authors.forename: H
authors.initials: H
authors.lastname: Obrig
authors.forename: S
authors.initials: S
authors.lastname: Ziegler
authors.forename: U
authors.initials: U
authors.lastname: Dirnagl
authors.forename: M
authors.initials: M
authors.lastname: Schwaiger
authors.forename: A
authors.initials: A
authors.lastname: Villringer
mesh_terms: D000368:Aged; D001931:Brain Mapping / Q000379:methods*; D002540:Cerebral Cortex / Q000000981:diagnostic imaging* / Q000378:metabolism; D002560:Cerebrovascular Circulation / Q000502:physiology*; D005069:Evaluation Studies as Topic; D005260:Female; D006454:Hemoglobins / Q000378:metabolism*; D006801:Humans; D008875:Middle Aged; D012016:Reference Values; D015203:Reproducibility of Results; D019265:Spectroscopy, Near-Infrared; D014055:Tomography, Emission-Computed
chemical_list: D006454:Hemoglobins