title: Cocaine use can increase cigarette smoking: evidence from laboratory and naturalistic settings.
abstract: Two studies examined the effects of cocaine use on cigarette smoking. Study 1 was conducted with 10 healthy volunteers under controlled laboratory conditions. Participants received double-blind doses of intranasal cocaine HCl (100 mg) or placebo in separate sessions, with each being followed by a 3-hr period of monitored cigarette smoking. Latency to the first cigarette and the mean interval between cigarettes was significantly shorter and the total number of cigarettes smoked was greater after cocaine than placebo administration. Study 2 was conducted by using urine specimens from 9 ambulatory cocaine-dependent patients. Urine cotinine (nicotine metabolite) levels on days when urinalysis testing indicated recent cocaine use were compared with levels on days when urinalysis testing indicated no recent use. Cotinine levels were significantly higher on cocaine-positive days, indicating that cocaine use was associated with greater cigarette smoking. Overall results provide evidence that acute cocaine administration can increase cigarette smoking.
authors.affiliation: Department of Psychiatry, University of Vermont, Burlington 05401-1419, USA.
authors.forename: J M
authors.initials: JM
authors.lastname: Roll
authors.forename: S T
authors.initials: ST
authors.lastname: Higgins
authors.forename: J
authors.initials: J
authors.lastname: Tidey
mesh_terms: D000293:Adolescent; D000328:Adult; D003042:Cocaine / Q000494:pharmacology*; D003367:Cotinine / Q000652:urine; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D009294:Narcotics / Q000494:pharmacology*; D012907:Smoking / Q000523:psychology*; D012931:Social Environment
chemical_list: D009294:Narcotics; D003042:Cocaine; D003367:Cotinine