N-[2-(1-azabicyclo[3.3.0]octan-5-yl)ethyl]-2-nitroaniline, a potent muscarinic agonist.
The muscarine receptor agonist SK-946, an aniline derivative with a characteristic bicyclo amine, was found. We describe a new synthetic method for 1-azabicyclo[3.3.0]octane and describe the biological activity of SK-946.
Suzuki
T
T
Drug Discovery Research Department, Sanwa Kagaku Kenkyusho Co., Ltd, Mie, Japan.
Oka
M
M
Maeda
K
K
Furusawa
K
K
Mitani
T
T
Kataoka
T
T
D000814:Aniline Compounds / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology*; D000818:Animals; D001643:Bridged Bicyclo Compounds / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology*; D002478:Cells, Cultured; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism / Q000648:ultrastructure; D003071:Cognition / Q000187:drug effects; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism / Q000648:ultrastructure; D018721:Muscarinic Agonists / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology*; D010716:Phosphatidylinositols / Q000378:metabolism; D051381:Rats; D011976:Receptors, Muscarinic / Q000378:metabolism
D000814:Aniline Compounds; D001643:Bridged Bicyclo Compounds; D018721:Muscarinic Agonists; C107666:N-(2-(1-azabicyclo(3.3.0)octan-5-yl)ethyl)-2-nitroaniline; D010716:Phosphatidylinositols; D011976:Receptors, Muscarinic