Power frequency magnetic fields do not contribute to transformation of JB6 cells.
The potential for power frequency magnetic fields to enhance neoplastic transformation has been investigated in vitro using promotion-sensitive mouse epidermal JB6 cells. In a soft agar assay, 60-Hz magnetic fields of 0.01, 0.1, 1.0, or 1.1 mT flux density did not induce anchorage-independent growth. In addition, these magnetic fields did not enhance tumor promoter-induced transformation showing no increase in the maximum number of transformed colonies and no shift in the dose-response curve. Thus, these data do not support the notion that environmental exposures to magnetic fields contribute to transformation.
Saffer
J D
JD
Molecular Biosciences Department, Pacific Northwest National Laboratory, Richland, WA 99352, USA.
Chen
G
G
Colburn
N H
NH
Thurston
S J
SJ
D000818:Animals; D001790:Blood Physiological Phenomena; D002471:Cell Transformation, Neoplastic; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D008280:Magnetics; D051379:Mice; D013755:Tetradecanoylphorbol Acetate / Q000633:toxicity
D013755:Tetradecanoylphorbol Acetate