title: Determination of nicotine content of popular cigarettes.
abstract: Accidental cigarette ingestion by children is a frequent occurrence in Japan where hundreds of cigarette brands (domestic and imported) are purchased. To evaluate the predictive value of the nicotine yield given on the label and determined by a smoking machine, we measured the actual nicotine content of tobacco in 33 popular cigarette brands. Average amounts of nicotine and tobacco/whole cigarette of 32 filter and 1 non-filter brands were as follows: 11.72 +/- 2.27 (SD) mg nicotine (range 6.94-18.33 mg) and 23.97 mg tobacco, and 0.67 +/- 0.07 g nicotine (range 0.49-0.79 g) and 1.02 g tobacco, respectively. Amounts of nicotine and tobacco in filter brands varied widely and were less than the data reported in the toxicological literature. Measured lengths of the part of cigarettes packed with tobacco ranged from 5.0 to 6.9 cm. The tobacco in low-yield cigarettes did not contain less nicotine than high-yield cigarettes, and the nicotine yield did not highly correlate with the nicotine content in the low-yield cigarette group (r = 0.243). We conclude that the nicotine yields on labels are not useful in estimating likely nicotine intake in cigarette-ingestion cases. The actual nicotine content of cigarettes should be included on the product label.
authors.affiliation: Division of Toxicology, School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Fukumoto
authors.forename: H
authors.initials: H
authors.lastname: Kubo
authors.forename: A
authors.initials: A
authors.lastname: Ogamo
mesh_terms: D002851:Chromatography, High Pressure Liquid; D004348:Drug Labeling; D009538:Nicotine / Q000032:analysis* / Q000302:isolation & purification; D010947:Plants, Toxic; D014026:Nicotiana / Q000737:chemistry*
chemical_list: D009538:Nicotine