The growth of human hair in nude mice.
The author reviews published papers on human hair growth in nude mice. There is evidence from various sources indicating that grafting of human scalp onto nude mice does not modify significantly morphogenesis, hair follicle structure and function, and composition of the newly grown hair fiber. On the basis of personal observations, the authors further highlights the results obtained in genetic hair defects. Hints are given as to the potential use of the model for drug discovery programs as the product can be used on the human target at early stages of drug development.
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Skin Study Center, Tournai, Belgium.
D000505:Alopecia / Q000209:etiology / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D000818:Animals; D006197:Hair / Q000201:enzymology / Q000254:growth & development* / Q000637:transplantation*; D006801:Humans; D051379:Mice; D008819:Mice, Nude