The treatment of autoimmune thrombocytopaenic purpura with anti-D immunoglobulin: similar platelet responses in homozygous and heterozygous Rh(D) positive patients.
Twenty-one patients with autoimmune thrombocytopaenic purpura (AITP) were treated with anti-D immunoglobulin. There was no significant difference with low and high dose anti-D treatment in the platelet count response between homozygous and heterozygous Rh(D) positive patients. The heterogeneous responses seen in Rh(D) positive AITP patients treated with anti-D immunoglobulin cannot therefore be explained by differences in Rh(D) phenotypes.
Smith
N A
NA
Department of Haematology, Queen Elizabeth Hospital, Birmingham, U.K.
Boughton
B J
BJ
D001792:Blood Platelets / Q000276:immunology*; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D010641:Phenotype; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000628:therapy*; D012204:Rh-Hr Blood-Group System / Q000235:genetics / Q000276:immunology*; D018029:Rho(D) Immune Globulin / Q000627:therapeutic use*
D012204:Rh-Hr Blood-Group System; D018029:Rho(D) Immune Globulin; C026410:Rho(D) antigen