Myoclonus in corticobasal degeneration.
Five patients with unilateral myoclonus and a clinical diagnosis of corticobasal degeneration (CBD) were studied. All patients showed enhanced long-loop responses in their myoclonic arms without enlarged somatosensory potentials. The cortical relay time of the long-loop responses was studied in three patients, in two of whom it was < 2 ms, even in the nonmyoclonic arm. Myoclonus in CBD is probably related to an enhanced long-loop reflex whose pathway is unlikely to be the same as that in classic cortical reflex myoclonus.
Carella
F
F
Division of Neurology, C. Besta National Neurological Institute, Milan, Italy.
Ciano
C
C
Panzica
F
F
Scaioli
V
V
D000368:Aged; D001132:Arm; D001479:Basal Ganglia / Q000503:physiopathology*; D001480:Basal Ganglia Diseases / Q000150:complications / Q000503:physiopathology; D001927:Brain Diseases / Q000150:complications / Q000503:physiopathology*; D002540:Cerebral Cortex / Q000503:physiopathology*; D005073:Evoked Potentials, Somatosensory; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009044:Motor Cortex / Q000503:physiopathology; D018482:Muscle, Skeletal / Q000503:physiopathology; D009207:Myoclonus / Q000209:etiology / Q000503:physiopathology*; D009410:Nerve Degeneration; D009431:Neural Conduction; D009434:Neural Pathways / Q000503:physiopathology; D010300:Parkinson Disease / Q000209:etiology / Q000503:physiopathology; D011930:Reaction Time; D012021:Reflex, Abnormal / Q000502:physiology*