Combinatorial synthesis of small-molecule libraries using 3-amino-5-hydroxybenzoic acid.
A non-peptide library of 2001 compounds has been prepared utilizing solid-phase techniques. The split/combine method was demonstrated to work well to form mixtures of compounds based on 3-amino-5-hydroxybenzoic acid as a core structure. The benzoic acid of the core structure served as the attachment point for the resin and the amino and hydroxy positions were variably substituted.
Dankwardt
S M
SM
Syntex Discovery Research, Chemical Research and Development, Palo Alto, CA 94304, USA.
Phan
T M
TM
Krstenansky
J L
JL
D062365:Aminobenzoates / Q000138:chemical synthesis* / Q000737:chemistry*; D002625:Chemistry, Organic; D002851:Chromatography, High Pressure Liquid; D019020:Directed Molecular Evolution / Q000379:methods*; D015195:Drug Design; D062385:Hydroxybenzoates; D015394:Molecular Structure; D055601:Organic Chemistry Phenomena; D012117:Resins, Synthetic / Q000138:chemical synthesis / Q000737:chemistry
D062365:Aminobenzoates; D062385:Hydroxybenzoates; D012117:Resins, Synthetic; C031509:3-amino-5-hydroxybenzoic acid