Keratoconjunctivitis sicca and primary Sjögren's syndrome in a Danish population aged 30-60 years.
OBJECTIVE
To investigate the presence of keratoconjunctivitis sicca and primary Sjögren's syndrome a sample of 504 persons aged 30-60 years from Copenhagen was studied.


METHODS
The presence of keratoconjunctivitis sicca and primary Sjögren's syndrome was estimated according to both the Copenhagen set of criteria and the preliminary European criteria.


RESULTS
Symptoms of dry eye and oral dryness were very common and with no significant correlation to age or sex. Keratoconjuncitivis sicca was most frequent in persons aged 50-59 years and was equally common in men and women. Primary Sjögren's syndrome could only be diagnosed in one person according to the Copenhagen criteria (cut-off the Schirmer-1 test < or = 5 mm/5 min), and in three persons according to the preliminary European criteria.


CONCLUSIONS
The frequency of keratoconjunctivitis sicca in persons aged 30-60 years in Copenhagen may be estimated to be 11% according to the Copenhagen criteria and 8% according to the preliminary European criteria. The frequency of primary Sjögren's syndrome in persons aged 30-60 years in Copenhagen may be estimated to be between 0.2% and 0.8% according to the Copenhagen criteria and between 0.6% and 2.1% according to the preliminary European criteria.
Bjerrum
K B
KB
Department of Ophthalmology, Rigshospitalet and Eye Pathology Institute, University of Copenhagen, Denmark.
D000328:Adult; D017677:Age Distribution; D003718:Denmark / Q000453:epidemiology; D005260:Female; D006801:Humans; D015994:Incidence; D007638:Keratoconjunctivitis Sicca / Q000175:diagnosis / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011446:Prospective Studies; D011897:Random Allocation; D012044:Regression Analysis; D017678:Sex Distribution; D012859:Sjogren's Syndrome / Q000175:diagnosis / Q000453:epidemiology*; D011795:Surveys and Questionnaires