Pharmacokinetics of cephalexin in cats after oral administration of the antibiotic in tablet and paste preparations.
OBJECTIVE
To determine the bioequivalence of a paste formulation of cephalexin with that of the tablet form.


METHODS
A two-way cross-over study.


METHODS
Ten adult cats of mixed breed.


METHODS
The cats, randomly allocated to two groups, received either the paste preparation or the tablet orally at 12-hour intervals for 48 h before a 12-hour blood collection period. Two weeks later the treatments were reversed and the blood sampling repeated. The serum concentrations of the antibiotic were determined. The pharmacokinetic factors were analysed using a computer.


RESULTS
There were no significant differences between the peak concentration of cephalexin, or the other pharmacokinetic factors obtained from the tablet and paste formulations. The serum profiles of cephalexin following four 12-hourly doses of each formulation were similar with the peak serum values occurring at approximately 2 h after administration.


CONCLUSIONS
The paste formulation and the tablet form are bioequivalent.
Thornton
J R
JR
Division of Companion Animal Clinical Sciences, School of Veterinary Science, University of Queensland.
Martin
P J
PJ
D000284:Administration, Oral; D000818:Animals; D002415:Cats / Q000378:metabolism*; D002506:Cephalexin / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D002511:Cephalosporins / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D018592:Cross-Over Studies; D005260:Female; D008297:Male; D009824:Ointments; D013607:Tablets; D013810:Therapeutic Equivalency; D013997:Time Factors
D002511:Cephalosporins; D009824:Ointments; D013607:Tablets; D002506:Cephalexin