A case of neonatal choriocarcinoma.
Choriocarcinoma occurring in a placenta and metastasizing to the fetus is quite rare. We describe here a case of such infantile choriocarcinoma, initially appeared as refractory anemia and rapidly metastasized to the liver, lungs, and brain. The placenta looked normal and was not submitted to histological examinations. Neither noninvasive nor invasive diagnostic methods (ultrasonography, computed tomography, magnetic resonance image, scintigraphy, and hepatic arteriography) gave any diagnostic information on the tumor. Liver biopsy was considered too risky due to a possible bleeding. Correct diagnosis was established only after the postmortem examination. Two months after the infant's death, we were informed that the mother was found having hepatic and pulmonary tumors. The importance of the maternal history and measurement of urinary human chorionic gonadotropin is emphasized for a rapid and correct diagnosis of infantile choriocarcinoma.
Kishkurno
S
S
Department of Pediatrics, Akita University School of Medicine, Japan.
Ishida
A
A
Takahashi
Y
Y
Arai
H
H
Nakajima
W
W
Abe
T
T
Takada
G
G
D000753:Anemia, Refractory / Q000209:etiology; D000792:Angiography; D001932:Brain Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary*; D002822:Choriocarcinoma / Q000000981:diagnostic imaging / Q000556:secondary*; D006063:Chorionic Gonadotropin / Q000652:urine; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D006828:Hydatidiform Mole / Q000473:pathology; D007231:Infant, Newborn; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary*; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary*; D008279:Magnetic Resonance Imaging; D010920:Placenta / Q000473:pathology; D011247:Pregnancy; D011877:Radionuclide Imaging; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography; D014594:Uterine Neoplasms / Q000473:pathology
D006063:Chorionic Gonadotropin