title: New anti-HIV-1, antimalarial, and antifungal compounds from Terminalia bellerica.
abstract: A bioactivity-guided fractionation of an extract of Terminalia bellerica fruit rind led to the isolation of two new lignans named termilignan (1) and thannilignan (2), together with 7-hydroxy-3',4'-(methylenedioxy)flavan (3) and anolignan B (4). All four compounds possessed demonstrable anti-HIV-1, antimalarial, and antifungal activity in vitro.
authors.affiliation: Division of Ethnopharmacology, Tropical Botanic Garden and Research Institute, Kerala, India.
authors.forename: R
authors.initials: R
authors.lastname: Valsaraj
authors.forename: P
authors.initials: P
authors.lastname: Pushpangadan
authors.forename: U W
authors.initials: UW
authors.lastname: Smitt
authors.forename: A
authors.initials: A
authors.lastname: Adsersen
authors.forename: S B
authors.initials: SB
authors.lastname: Christensen
authors.forename: A
authors.initials: A
authors.lastname: Sittie
authors.forename: U
authors.initials: U
authors.lastname: Nyman
authors.forename: C
authors.initials: C
authors.lastname: Nielsen
authors.forename: C E
authors.initials: CE
authors.lastname: Olsen
mesh_terms: D019380:Anti-HIV Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification; D009682:Magnetic Resonance Spectroscopy; D010946:Plants, Medicinal / Q000737:chemistry*
chemical_list: C107721:7-hydroxy-3',4'-(methylenedioxy)flavan; D019380:Anti-HIV Agents; D000935:Antifungal Agents; D000962:Antimalarials; D005419:Flavonoids; D017705:Lignans