Studies on the site of renal tubular defect in Bartter's syndrome.
Renal tubular function was studied in an 8-month-old male infant with Bartter's syndrome, which is characterized by hypokalemic metabolic alkalosis, normotensive hyperreninemic hyperaldosteronism, and reduced pressor response to angiotensin II. Chloride transport along the diluting segment (CH2O/CH2O + CCl) was impaired. Furthermore, furosemide did not elicit normal natriuresis, which suggested impaired chloride reabsorptive capacity at the furosemide-sensitive ascending limb of Henle's loop. Loss of antidiuretic hormone-mediated urinary concentration was in support of this. These findings pointed to the thick ascending limb of Henle's loop as the site of the primary defect in this child.
Kikuchi
M
M
Department of Pediatrics, Hitachi General Hospital, Japan.
Sato
M
M
Chiba
A
A
Chiba
Y
Y
Nagao
K
K
Suzuki
T
T
Fujigaki
Y
Y
Hoshino
H
H
D001477:Bartter Syndrome / Q000503:physiopathology*; D002712:Chlorides / Q000378:metabolism; D004231:Diuresis; D004232:Diuretics; D005665:Furosemide; D006801:Humans; D007223:Infant; D008138:Loop of Henle / Q000503:physiopathology*; D008297:Male; D012965:Sodium Chloride / Q000378:metabolism
D002712:Chlorides; D004232:Diuretics; D012965:Sodium Chloride; D005665:Furosemide