Single-particle tracking: applications to membrane dynamics.
Measurements of trajectories of individual proteins or lipids in the plasma membrane of cells show a variety of types of motion. Brownian motion is observed, but many of the particles undergo non-Brownian motion, including directed motion, confined motion, and anomalous diffusion. The variety of motion leads to significant effects on the kinetics of reactions among membrane-bound species and requires a revision of existing views of membrane structure and dynamics.
Saxton
M J
MJ
Institute of Theoretical Dynamics, University of California, Davis 95616, USA. mjsaxton@ucdavis.edu
Jacobson
K
K
D004058:Diffusion; D006801:Humans; D008560:Membrane Fluidity / Q000502:physiology*; D008563:Membrane Lipids / Q000378:metabolism*; D008565:Membrane Proteins / Q000378:metabolism*; D018715:Microscopy, Video / Q000379:methods*
D008563:Membrane Lipids; D008565:Membrane Proteins