title: A new 99mTc-complex with a germanium-hydrazide (GeTH) ligand.
abstract: A new tetrahydrazido-germanium (GeTH) ligand was synthesized, characterized and complexed with 99mTc. The negatively charged 99mTc-chelate was shown to form in high yields at neutral pH in the absence of other reducing agents and exhibits high in vitro and in vivo stability.
authors.affiliation: Department of Radiology, University of Missouri, Columbia, USA.
authors.forename: P R
authors.initials: PR
authors.lastname: Singh
authors.forename: K K
authors.initials: KK
authors.lastname: Katti
authors.forename: K V
authors.initials: KV
authors.lastname: Katti
authors.forename: M
authors.initials: M
authors.lastname: Corlija
authors.forename: A R
authors.initials: AR
authors.lastname: Ketring
authors.forename: W A
authors.initials: WA
authors.lastname: Volkert
authors.forename: R R
authors.initials: RR
authors.lastname: Holmes
mesh_terms: D000818:Animals; D006834:Hydrazines / Q000493:pharmacokinetics; D006863:Hydrogen-Ion Concentration; D015609:Organotechnetium Compounds / Q000493:pharmacokinetics; D010084:Oxidation-Reduction; D011854:Radiochemistry; D019275:Radiopharmaceuticals / Q000737:chemistry* / Q000493:pharmacokinetics; D051381:Rats; D017207:Rats, Sprague-Dawley; D014018:Tissue Distribution
chemical_list: D006834:Hydrazines; D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; C107870:technetium Tc 99m tetrakis(hydrazidomethyl)germanium