title: Role of vacuolating cytotoxin in gastritis due to Helicobacter pylori in gnotobiotic piglets.
abstract: To investigate the role of the Helicobacter pylori cytotoxin in the pathogenesis of gastritis, gnotobiotic piglets were colonized with either toxigenic H. pylori or a nontoxigenic isogenic mutant. Only piglets given the toxigenic strain developed toxin-neutralizing antibodies (indicating that toxin is expressed in vivo), but there was no difference in bacterial colonization, epithelial vacuolation, or gastritis between the two groups of piglets.
authors.affiliation: Department of Veterinary Biosciences, Ohio State University, Columbus 43210, USA. keaton@magnus.acs.ohio-state.edu
authors.forename: K A
authors.initials: KA
authors.lastname: Eaton
authors.forename: T L
authors.initials: TL
authors.lastname: Cover
authors.forename: M K
authors.initials: MK
authors.lastname: Tummuru
authors.forename: M J
authors.initials: MJ
authors.lastname: Blaser
authors.forename: S
authors.initials: S
authors.lastname: Krakowka
mesh_terms: D000818:Animals; D001426:Bacterial Proteins / Q000633:toxicity*; D003603:Cytotoxins / Q000633:toxicity*; D005756:Gastritis / Q000209:etiology*; D005856:Germ-Free Life; D016480:Helicobacter pylori / Q000472:pathogenicity*; D013552:Swine
chemical_list: D001426:Bacterial Proteins; D003603:Cytotoxins; C074689:VacA protein, Helicobacter pylori