title: Helicobacter pylori infection and gastric emptying of indigestible solids in patients with dysmotility-like dyspepsia.
abstract: BACKGROUND
  The role of Helicobacter pylori and gastric motility in dysmotility-like dyspepsia is unclear. The aim of this study was to determine whether delayed gastric emptying of indigestible solids and H. pylori infection are associated with dysmotility-like dyspepsia.
  
  
  METHODS
  Thirty-two healthy volunteers and 72 patients fulfilling the criteria of dysmotility-like dyspepsia received a gastric emptying test using radiopaque markers, and the H. pylori status was determined by histology.
  
  
  RESULTS
  Twenty-seven percent of volunteers were H. pylori-positive, compared with 32% in the dyspeptic groups (P = NS). Gastric emptying was significantly slower in dyspeptic patients than controls and in H. pylori-positive patients than H. pylori-negative patients. Subjects with gastroparesis have a higher chance of developing dysmotility-like dyspepsia (odds ratio (OR), 2.5) than subjects with normal gastric emptying. Subjects with H. pylori and gastroparesis have an increased likelihood of developing dysmotility-like dyspepsia (OR, 4.3) than if either factor were present alone.
  
  
  CONCLUSIONS
  Our data suggest that gastroparesis alone and gastroparesis and H. pylori infection are associated with dysmotility-like dyspepsia.
authors.affiliation: Dept. of Medicine, Toa Payoh Hospital, Singapore.
authors.forename: K M
authors.initials: KM
authors.lastname: Fock
authors.forename: T K
authors.initials: TK
authors.lastname: Khoo
authors.forename: K S
authors.initials: KS
authors.lastname: Chia
authors.forename: C S
authors.initials: CS
authors.lastname: Sim
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D004415:Dyspepsia / Q000382:microbiology* / Q000503:physiopathology*; D005260:Female; D005502:Food; D005746:Gastric Emptying / Q000502:physiology*; D005769:Gastrointestinal Motility / Q000502:physiology; D018589:Gastroparesis / Q000382:microbiology* / Q000503:physiopathology*; D016481:Helicobacter Infections / Q000503:physiopathology*; D016480:Helicobacter pylori; D006801:Humans; D008297:Male