[Inhibitory effect of the radiosensitizer AK-2123 on experimental liver metastasis and active transport of calcium ions].
Radiosensitizer AK-2123, a triazol, has been shown to significantly inhibit the development of hepatic metastases induced in syngeneic mice by intrasplenic injections with cels of bowel adenocarcinoma. The antimetastatic effect was produced by use of a very low dose of the drug. A therapeutic dose of AK-2123 has been shown to inhibit active transport of calcium ions across sarcoplasmic reticular cells effected by Ca(2+)-dependent Mg(2+)-activated ATPase. It is suggested that the antimetastatic effect of AK-2123 is determined by at least partial inhibition of active transport of calcium.
Konovalova
N P
NP
Kinki Center for Inventions, Kyoto, Japan.
Volkova
L M
LM
Tat'ianenko
L V
LV
Kotel'nikova
R A
RA
Iakushchenko
T N
TN
Kagiia
T
T
D000230:Adenocarcinoma / Q000517:prevention & control* / Q000556:secondary; D000818:Animals; D000964:Antimetabolites, Antineoplastic / Q000494:pharmacology; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D005260:Female; D005472:Fluorouracil / Q000494:pharmacology; D008114:Liver Neoplasms, Experimental / Q000517:prevention & control* / Q000556:secondary; D051379:Mice; D008807:Mice, Inbred BALB C; D011838:Radiation-Sensitizing Agents / Q000494:pharmacology*; D013997:Time Factors; D014230:Triazoles / Q000494:pharmacology*
D000964:Antimetabolites, Antineoplastic; D002121:Calcium Channel Blockers; D011838:Radiation-Sensitizing Agents; D014230:Triazoles; C072690:AK 2123; D005472:Fluorouracil
Ingibiruiushchiĭ éffekt radiosensibilizatora AK-2123 na éksperimental'nye metastazy v pecheni i aktivnyĭ transport ionov kal'tsiia.