Sequence-specific 1H, 13C and 15N assignment of the TMP-resistant dihydrofolate reductase mutant DHFR(F98Y) in the ternary complex with TMP and NADPH.
Altmann
S
S
Pharma Division, F. Hoffmann-La Roche Ltd, Basel, Switzerland.
Labhardt
A M
AM
Senn
H
H
Wüthrich
K
K
D005493:Folic Acid Antagonists / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D009154:Mutation; D009249:NADP / Q000737:chemistry*; D011487:Protein Conformation; D013211:Staphylococcus aureus / Q000187:drug effects / Q000235:genetics; D013762:Tetrahydrofolate Dehydrogenase / Q000737:chemistry* / Q000235:genetics; D014295:Trimethoprim / Q000737:chemistry*; D014296:Trimethoprim Resistance / Q000235:genetics*
D005493:Folic Acid Antagonists; D009249:NADP; D014295:Trimethoprim; D013762:Tetrahydrofolate Dehydrogenase