Studies on in vivo antitussive activity of Leucas lavandulaefolia using a cough model induced by sulfur dioxide gas in mice.
The methanol extract of Leucas lavandulaefolia was investigated for its effects on a cough model induced by sulfur dioxide gas in mice. It exhibited significant antitussive activity when compared with control in a dose-dependent manner. The antitussive activity of the extract was comparable to that of codeine phosphate (10 mg/kg), a prototype antitussive agent. The Leucas lavandulaefolia extract at 100, 200, and 400 mg/kg. p.o. showed inhibition of cough by 35.0, 51.9, and 56.5% within 1 h of performing the experiment.
Saha
K
K
Department of Pharmaceutical Technology, Faculty of Engineering and Technology, Jadavpur University, Calcutta, India.
Mukherjee
P K
PK
Murugesan
T
T
Saha
B P
BP
Pal
M
M
D000818:Animals; D000996:Antitussive Agents / Q000627:therapeutic use*; D003061:Codeine / Q000627:therapeutic use; D003371:Cough / Q000139:chemically induced / Q000188:drug therapy*; D004195:Disease Models, Animal; D005260:Female; D008297:Male; D051379:Mice; D010946:Plants, Medicinal / Q000737:chemistry*; D013458:Sulfur Dioxide / Q000633:toxicity*
D000996:Antitussive Agents; D013458:Sulfur Dioxide; D003061:Codeine