Accelerating effect of chitosan intake on urinary calcium excretion by rats.
The effect of chitosan on calcium (47Ca) metabolism was investigated in rats. The whole-body retention of 47Ca by rats fed on a 5% chitosan diet was significantly decreased when compared with that of rats fed on a cellulose diet, but showed no significant difference from that of rats fed on a fiber-free diet. Although there was no significant difference in the fecal excretion of 47Ca between the chitosan group and the cellulose or fiber-free group, the urinary excretion of 47Ca was significantly increased in the chitosan group when compared with the cellulose group. These results suggest that dietary chitosan would affect the calcium metabolism in animals.
Wada
M
M
Department of Nutrition, Tokyo University of Agriculture, Japan.
Nishimura
Y
Y
Watanabe
Y
Y
Takita
T
T
Innami
S
S
D000284:Administration, Oral; D000818:Animals; D002118:Calcium / Q000378:metabolism / Q000493:pharmacokinetics* / Q000652:urine*; D002132:Calcium Radioisotopes / Q000008:administration & dosage; D002482:Cellulose / Q000494:pharmacology; D002686:Chitin / Q000031:analogs & derivatives* / Q000494:pharmacology; D048271:Chitosan; D004043:Dietary Fiber / Q000494:pharmacology; D005243:Feces / Q000737:chemistry; D007275:Injections, Intravenous; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D014018:Tissue Distribution
D002132:Calcium Radioisotopes; D004043:Dietary Fiber; D002686:Chitin; D002482:Cellulose; D048271:Chitosan; D002118:Calcium