Neuroendocrine asymmetry.
The information available at present clearly indicates that asymmetry exists from the level of elementary particles to the human cerebral cortex, the latest stage of evolution. Cerebral lateralization is one of the well-known asymmetries. This paper summarizes the data published in the past decades on the asymmetry of the neuroendocrine system. The information on the sided-differences between the gonads, adrenals, and thyroid lobes and that on the lateralization of hypothalamic, limbic, and other brain structures participating in the control of the endocrine glands as well as relevant clinical observations are reviewed here. The innervation of the peripheral endocrine glands is also briefly summarized because the afferent and efferent fibers of these glands may represent one part of the pathway involved in neuroendocrine asymmetry. The data reviewed clearly indicate that some kind of asymmetry (morphological, biochemical, physiological, pathological) is evident at different levels of the neuroendocrine system (at limbic, hypothalamic, peripheral endocrine glands and their innervation) and there are species, sex, and age differences. Most of the information accumulated deals with the CNS-gonadal system. A majority of the observations suggest that in both male and female rats there is a predominance of the right half of brain structures controlling gonadal function. The asymmetry, however, is not restricted to CNS structures: it also exists at the level of the gonads, including their innervation. It appears that the characteristic pattern of the CNS-gonadal system becomes fixed only after sexual maturation. Very few reports are available suggesting some kind of asymmetry of the CNS-adrenal cortex and the CNS-thyroid system. There are convincing findings consistent with the view that in addition to the hypothalamo-adenohypophyseal system acting via the general circulation on the peripheral endocrine glands, there is also a pure neural link between the CNS and the gonads, the CNS and the adrenal gland, and also between the CNS and the thyroid. This link contains afferent and efferent pathways and is able to modulate the functional activity or the responsiveness of the gland. It may also serve as a neural reflex arc. It is assumed that the neuroendocrine asymmetry expresses itself through (i) hypophysiotrophic neurohormones and hormones of the peripheral endocrine glands, (ii) neural pathways, or (iii) a combination of (i) and (ii). The authors hope that this publication, in addition to providing an overview, will also stimulate research, both basic and clinical, in this exciting area of neuroendocrinology.
Gerendai
I
I
Department of Human Morphology and Developmental Biology, Semmelweis University of Medicine, Budapest, Hungary.
Halász
B
B
D000311:Adrenal Glands / Q000502:physiology; D000818:Animals; D001921:Brain / Q000502:physiology*; D004702:Endocrine Glands / Q000502:physiology; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D008297:Male; D009490:Neurosecretory Systems / Q000502:physiology*; D010053:Ovary / Q000502:physiology; D013737:Testis / Q000502:physiology; D013961:Thyroid Gland / Q000502:physiology