title: Nasopharyngeal cryptococcosis.
abstract: Naturally occurring cryptococcosis in five cats, a dog and a koala is described. Involvement of the nasopharynx was documented in all patients, and nasopharyngeal mass lesions accounted for the major presenting complaints in four. Signs referable to nasopharyngeal disease included snoring, stertor, inspiratory dyspnoea and aerophagia. Diagnoses were made by caudal rhinoscopy using a retroverted flexible endoscope, vigorous orthograde flushing with saline, or at necropsy. Concurrent cryptococcal rhinitis was present in all cases, although involvement appeared limited to the caudal nasal cavity in most cases. Typical signs of nasal cavity disease, such as sneezing and nasal discharge, were often absent. Treatment of nasopharyngeal cryptococcosis should include physical dislodgement or debulking of lesion(s) to provide immediate alleviation of upper airway obstruction, followed by systemic antifungal therapy to eliminate residual infection from the nasal cavity. Infections caused by Cryptococcus neoformans var gattii accounted for a disproportionately large number of these cases.
authors.affiliation: Department of Veterinary Clinical Sciences, University of Sydney, New South Wales.
authors.forename: R
authors.initials: R
authors.lastname: Malik
authors.forename: P
authors.initials: P
authors.lastname: Martin
authors.forename: D I
authors.initials: DI
authors.lastname: Wigney
authors.forename: D B
authors.initials: DB
authors.lastname: Church
authors.forename: W
authors.initials: W
authors.lastname: Bradley
authors.forename: C R
authors.initials: CR
authors.lastname: Bellenger
authors.forename: W A
authors.initials: WA
authors.lastname: Lamb
authors.forename: V R
authors.initials: VR
authors.lastname: Barrs
authors.forename: S
authors.initials: S
authors.lastname: Foster
authors.forename: S
authors.initials: S
authors.lastname: Hemsley
authors.forename: P J
authors.initials: PJ
authors.lastname: Canfield
authors.forename: D N
authors.initials: DN
authors.lastname: Love
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000627:therapeutic use; D001706:Biopsy / Q000379:methods / Q000662:veterinary; D002371:Cat Diseases / Q000175:diagnosis* / Q000382:microbiology / Q000628:therapy; D002415:Cats; D003453:Cryptococcosis / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*; D003454:Cryptococcus / Q000302:isolation & purification; D004283:Dog Diseases / Q000175:diagnosis* / Q000382:microbiology / Q000628:therapy; D004285:Dogs; D004724:Endoscopy / Q000379:methods / Q000662:veterinary; D005260:Female; D008264:Macrophages / Q000473:pathology; D008297:Male; D008394:Marsupialia; D009302:Nasopharyngeal Diseases / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*; D009305:Nasopharynx / Q000382:microbiology / Q000473:pathology / Q000601:surgery; D012220:Rhinitis / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary
chemical_list: D000935:Antifungal Agents