Essential biochemical design features of the fuel-sensing system in pancreatic beta-cells.
The beta-cells of the pancreas control the blood levels of glucose and other nutrients by secreting insulin. They sense blood nutrient levels not by using a classical receptor-signaling system, but by detecting the products of nutrient metabolism. Mutations in this pathway can cause diabetes or hypoglycemia.
Matschinsky
F M
FM
Diabetes Research Center, University of Pennsylvania School of Medicine, 501 Stemmler Hall, 36th and Hamilton Walk, Philadelphia, PA 19104-6015, USA.
Collins
H W
HW
D000596:Amino Acids / Q000378:metabolism; D002118:Calcium / Q000378:metabolism; D003920:Diabetes Mellitus / Q000378:metabolism; D004734:Energy Metabolism; D005941:Glucokinase / Q000172:deficiency / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D006706:Homeostasis; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000378:metabolism*; D050356:Lipid Metabolism; D015221:Potassium Channels / Q000378:metabolism; D015398:Signal Transduction
D000596:Amino Acids; D007328:Insulin; D015221:Potassium Channels; D005941:Glucokinase; D005947:Glucose; D002118:Calcium