Growth hormone is not safe for children with renal transplants.
Growth failure is an important problem in children with renal failure. Even after renal transplantation their growth rates may be lower than normal, and "catch-up" growth does not occur. Therefore there is great interest in giving growth hormone (GH) after transplantation. Clinical observations and theoretic considerations call into question whether GH after transplantation is safe. Studies have shown a more rapid than normal decline in renal function after the initiation of GH therapy. This result could be explained by the effects of GH on the immune response. Growth hormone is known to modulate (usually upregulate) the immune response and could be a reason for the increased loss of renal function caused by rejection. It could also be explained by the long-term effects of GH on the injured kidney. Experimental data (generally not in the transplantation model) suggest that exogenous GH given after renal injury or reduced renal mass leads to a more rapid development of glomerular sclerosis and reduced renal function. GH should not be administered to children after renal transplantation until all safety questions have been answered in prospective clinical trials.
Friedman
A L
AL
Department of Pediatrics, University of Wisconsin Medical School, Madison, USA.
D000818:Animals; D002648:Child; D002986:Clinical Trials as Topic; D004195:Disease Models, Animal; D005923:Glomerulosclerosis, Focal Segmental / Q000209:etiology; D006084:Graft Rejection / Q000209:etiology / Q000276:immunology; D006128:Growth / Q000187:drug effects; D006130:Growth Disorders / Q000209:etiology; D019382:Human Growth Hormone / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D016030:Kidney Transplantation / Q000276:immunology / Q000502:physiology; D011446:Prospective Studies; D051437:Renal Insufficiency / Q000150:complications / Q000601:surgery; D012449:Safety; D014181:Transplantation Immunology / Q000187:drug effects; D015854:Up-Regulation
D019382:Human Growth Hormone