title: Hormonal regulation of N-cadherin mRNA levels in rat granulosa cells.
abstract: We have examined the ability of hormones to modulate the steady-state levels of N-cadherin mRNA transcripts in aggregated and dispersed rat granulosa cell populations. Estradiol and follicle-stimulating hormone (FSH) had no effect on the levels of N-cadherin mRNA transcripts in aggregated granulosa cells. In contrast, these two hormones stimulated N-cadherin mRNA levels in dispersed granulosa cells. This is the first report that estradiol and FSH are capable of regulating N-cadherin mRNA levels. The results also suggest that the N-cadherin mRNA levels in dispersed and aggregated granulosa cells are regulated by different mechanisms.
authors.affiliation: Department of Physiology, McGill University, Montreal, Quebec, Canada.
authors.forename: R
authors.initials: R
authors.lastname: Farookhi
authors.forename: C S
authors.initials: CS
authors.lastname: Geng
authors.forename: C D
authors.initials: CD
authors.lastname: MacCalman
authors.forename: O W
authors.initials: OW
authors.lastname: Blaschuk
mesh_terms: D000818:Animals; D001345:Autoradiography; D015152:Blotting, Northern; D015820:Cadherins / Q000235:genetics / Q000378:metabolism*; D005260:Female; D006107:Granulosa Cells / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism*; D051381:Rats
chemical_list: D015820:Cadherins; D012333:RNA, Messenger