title: Direct preparation of cyclodextrin monophosphates.
abstract: Aqueous solutions of cyclodextrins and inorganic metaphosphate at pH 4, upon drying and subsequent warming, produce mixtures of isomeric monophosphate esters which are amenable to separation by anion-exchange chromatography. The products are characterised by enzymatic, mass, and NMR spectroscopic analysis. The methodology provides a route to these derivatives by a single reaction.
authors.affiliation: Joint Microbiology Research Unit, Kings College School of Medicine and Dentistry, London, UK. rcbm800@kcl.ac.uk
authors.forename: E
authors.initials: E
authors.lastname: Tarelli
authors.forename: X
authors.initials: X
authors.lastname: Lemercinier
authors.forename: S
authors.initials: S
authors.lastname: Wheeler
mesh_terms: D002240:Carbohydrate Sequence; D002852:Chromatography, Ion Exchange; D003505:Cyclodextrins / Q000138:chemical synthesis* / Q000737:chemistry / Q000302:isolation & purification; D009682:Magnetic Resonance Spectroscopy; D008969:Molecular Sequence Data; D010710:Phosphates / Q000138:chemical synthesis* / Q000737:chemistry; D010757:Phosphorous Acids / Q000737:chemistry; D047391:alpha-Cyclodextrins; D047392:beta-Cyclodextrins
chemical_list: D003505:Cyclodextrins; D010710:Phosphates; D010757:Phosphorous Acids; D047391:alpha-Cyclodextrins; D047392:beta-Cyclodextrins; C031215:betadex; C043639:metaphosphoric acid; C032613:alpha-cyclodextrin