[Results of the treatment with fast neutrons (d.T 13 MeV) in recurrent rectal carcinoma].
OBJECTIVE
In spite of improved surgical techniques and the use of multiple modality treatment schemes the local recurrence rate of colorectal carcinomas could not be successfully reduced up to now. Besides surgical treatment of local recurrences in some cases radiation therapy may be indicated.


METHODS
In the Department of Radiotherapy of the University of Münster 37 patients with recurrent rectal carcinoma were treated between the end of 1985 and September 1992 either with fast neutrons alone or with a combined photon-neutron therapy. Eighteen patients received radiotherapy with fast neutrons (14 MeV d,T) alone; the tumor dose was between 10 and 15 Gy neutrons. Nineteen patients were irradiated with a mixed-beam schedule consisting of 30 to 45 Gy photons (X 10 MV) and neutron doses ranging from 5 to 10 Gy.


RESULTS
In 30 patients a good or complete pain relief could be observed immediately after the last irradiation. Sixteen out of 37 patients had local tumor regrowth during the follow-up period. The median survival for all 37 patients was 15.9 months. The probability for survival was 86% after 6 months and 61% after 12 months (Kaplan-Meier). The side effects were slight to moderate (EORTC/RTOG I-II).


CONCLUSIONS
This therapy showed good results concerning a fast and effective pain relief. Additionally the results seem to show a good effect concerning local control and overall survival in this negatively selected patients.
Prott
F J
FJ
Klinik und Poliklinik für Strahlentherapie und Radioonkologie, Westfälische Wilhelms-Universität Münster.
Pötter
R
R
Preusser
P
P
Micke
O
O
Schouwink
A
A
Willich
N
N
D000230:Adenocarcinoma / Q000000981:diagnostic imaging / Q000401:mortality / Q000532:radiotherapy*; D000328:Adult; D000368:Aged; D005214:Fast Neutrons / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000000981:diagnostic imaging / Q000401:mortality / Q000532:radiotherapy*; D017785:Photons / Q000627:therapeutic use; D011336:Probability; D011878:Radiotherapy / Q000009:adverse effects; D011879:Radiotherapy Dosage; D012004:Rectal Neoplasms / Q000000981:diagnostic imaging / Q000401:mortality / Q000532:radiotherapy*; D016019:Survival Analysis; D013997:Time Factors; D014057:Tomography, X-Ray Computed
Ergebnisse der Behandlung von Rektumkarzinomrezidiven mit schnellen Neutronen (d,T 14 MeV).