Improving outcome of malignant brain tumours in very young children: a population-based study in Finland during 1975-93.
Sixty-four children with malignant brain tumours diagnosed at less than 3 years of age were reported to the Finnish Cancer Registry from 1975 to 1993. The survival rate has improved significantly: the 5-year survival rate was 26% for all children, 13% for children diagnosed during 1975-85 (n = 30) and 40% for those diagnosed during 1986-93 (n = 34). Of the surviving children in 1986-93, 43% were categorized in Bloom's group I or II and could lead active lives without major disabilities. The remaining children had severe neurologic late complications, such as hemiplegia, intractable seizures, and mental retardation.
Ilveskoski
I
I
Children's Hospital, University of Helsinki, Finland.
Pihko
H
H
Sankila
R
R
Lanning
M
M
Perkkiö
M
M
Aarimaa
T
T
Mäkipernaa
A
A
Saarinen
U M
UM
D000367:Age Factors; D001932:Brain Neoplasms / Q000175:diagnosis / Q000401:mortality* / Q000503:physiopathology / Q000628:therapy*; D002675:Child, Preschool; D003071:Cognition / Q000502:physiology; D003131:Combined Modality Therapy; D018572:Disease-Free Survival; D005069:Evaluation Studies as Topic; D005260:Female; D005387:Finland / Q000453:epidemiology; D006801:Humans; D007223:Infant; D008297:Male; D009048:Motor Skills / Q000502:physiology; D011183:Postoperative Complications; D011379:Prognosis; D011788:Quality of Life; D012042:Registries; D015996:Survival Rate