Surface studies of albumin immobilized onto PE and PVC films.
The aim of this study is to evaluate the thrombogenic behaviour of the low density polyethylene and poly(vinyl chloride) modified by radiation-grafting technique. After copolymerization with acrylic acid by gamma-rays from a 60Co source, BSA was immobilized onto functionalized graft copolymers. The biological interaction between these materials and blood was studies by in vitro methods. The BSA immobilization effectively suppressed the adhesion and activation of platelets when it contacted whole blood.
de Queiroz
A A
AA
Escola Federal de Engenharia de Itajubá, Instituto de Ciëncias, Brazil.
Barrak
E R
ER
Gil
H A
HA
Higa
O Z
OZ
D000179:Acrylates / Q000737:chemistry* / Q000378:metabolism / Q000633:toxicity; D000327:Adsorption; D000818:Animals; D001665:Binding Sites; D001672:Biocompatible Materials / Q000737:chemistry / Q000378:metabolism / Q000633:toxicity*; D001777:Blood Coagulation / Q000187:drug effects; D001792:Blood Platelets / Q000378:metabolism / Q000648:ultrastructure; D002417:Cattle; D004337:Drug Carriers / Q000592:standards; D005340:Fibrinogen / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D008855:Microscopy, Electron, Scanning; D008970:Molecular Weight; D015539:Platelet Activation / Q000187:drug effects; D010973:Platelet Adhesiveness / Q000187:drug effects; D011095:Polyethylenes / Q000737:chemistry* / Q000378:metabolism / Q000633:toxicity; D011143:Polyvinyl Chloride / Q000737:chemistry* / Q000378:metabolism / Q000633:toxicity; D012710:Serum Albumin, Bovine / Q000378:metabolism*; D017550:Spectroscopy, Fourier Transform Infrared; D013927:Thrombosis / Q000139:chemically induced*
D000179:Acrylates; D001672:Biocompatible Materials; D004337:Drug Carriers; D011095:Polyethylenes; D012710:Serum Albumin, Bovine; D005340:Fibrinogen; D011143:Polyvinyl Chloride; C036658:acrylic acid