title: The Escherichia coli cell cycle, cell division and ppGpp: regulation and mechanisms.
abstract: The literature demonstrating tight regulation of the Escherichia coli cell cycle is reviewed. Recent evidence is presented indicating that the normal rod cell shape can be abandoned, allowing growth as a coccus, either by increasing the amount of the division proteins FtsZ, FtsA and FtsQ, or by increasing the pool of the nucleotide ppGpp. It is argued that ppGpp may be a cell cycle signal in E. coli.
authors.affiliation: Institut Jacques Monod, CNRS, Université Paris 7, Paris, France.
authors.forename: R
authors.initials: R
authors.lastname: D'Ari
mesh_terms: D002453:Cell Cycle / Q000502:physiology*; D004926:Escherichia coli / Q000166:cytology / Q000254:growth & development*; D006159:Guanosine Tetraphosphate / Q000378:metabolism*; D008957:Models, Genetic
chemical_list: D006159:Guanosine Tetraphosphate