Inhalation cough challenge in the investigation of the cough reflex and antitussives.
Inhalation cough challenge is a useful tool in the physiological and pharmacological investigation of the cough reflex. There are three types of challenge used, capsaicin and the vanilloids, organic acids, and distilled water challenge. In addition, challenge may be administered in a single dose or cumulative dose fashion. The correct combination of inhalation technology and tussive stimulus produces a sensitive and specific method for estimating the cough reflex.
Morice
A H
AH
Department of Medicine and Pharmacology, Royal Hallamshire Hospital, Sheffield, UK.
D000996:Antitussive Agents / Q000008:administration & dosage / Q000494:pharmacology*; D002211:Capsaicin / Q000008:administration & dosage / Q000494:pharmacology*; D019343:Citric Acid / Q000008:administration & dosage / Q000494:pharmacology*; D003371:Cough / Q000139:chemically induced / Q000503:physiopathology*; D004224:Diterpenes / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D008168:Lung / Q000187:drug effects / Q000502:physiology; D012021:Reflex, Abnormal / Q000187:drug effects* / Q000502:physiology; D012143:Respiratory Physiological Phenomena; D012137:Respiratory System / Q000187:drug effects; D014867:Water / Q000494:pharmacology*
D000996:Antitussive Agents; D004224:Diterpenes; D014867:Water; D019343:Citric Acid; C024353:resiniferatoxin; D002211:Capsaicin