Intravenous aminophylline increases the degree of saturation of urine with calcium phosphate and struvite.
This study was designed to assess the effect of i.v. treatment with aminophylline (AMPH) on the risk of calcium phosphate and struvite stone formation. We administered AMPH in doses of 4 mg/kg body weight in 15-min i.v. infusions to 60 infants with clinical symptoms of obstructive bronchitis with dyspnoea. During 3 hours after infusion we observed a significant increase in urine saturation with brushite, octocalcium phosphate and struvite. This rise in urine saturation may increase the risk of kidney stone formation.
Siwińska
A
A
IInd Clinic of Paediatrics, University School of Medical Science, Poznań, Poland.
Głuszek
J
J
Maciejewski
J
J
Musialik
D
D
D000628:Aminophylline / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D001991:Bronchitis / Q000188:drug therapy; D001993:Bronchodilator Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D002130:Calcium Phosphates / Q000652:urine*; D004417:Dyspnea / Q000188:drug therapy; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007223:Infant; D007262:Infusions, Intravenous; D007669:Kidney Calculi / Q000139:chemically induced* / Q000652:urine; D017616:Magnesium Compounds / Q000652:urine*; D008297:Male; D010710:Phosphates / Q000652:urine*; D012307:Risk Factors; D000069877:Struvite
D001993:Bronchodilator Agents; D002130:Calcium Phosphates; D017616:Magnesium Compounds; D010710:Phosphates; C485828:alpha-tricalcium phosphate; C485830:tetracalcium phosphate; D000628:Aminophylline; C485838:calcium phosphate, monobasic, anhydrous; C020243:calcium phosphate; D000069877:Struvite; C485829:calcium phosphate, dibasic, anhydrous