Pigmented peripheral nerve sheath tumor of the oral cavity with expression of AP-2 beta and c-RET: a case report.
Pigmented peripheral nerve sheath tumor of the oral cavity is a rare lesion and may be difficult to distinguish clinically from true melanocytic tumors. We report a case of pigmented peripheral nerve sheath tumor with a high degree of melanocytic differentiation and describe its histologic and ultrastructural features. Immunohistochemistry and polymerase chain reaction findings support the neural crest origin of the tumor. The clinical course of our case indicates that local recurrence may be a significant problem in pigmented peripheral nerve sheath tumor.
Dammer
R
R
Department of Head and Neck Surgery, University of Regensburg Medical School, Germany.
Stavenow
J
J
Held
P
P
Schröder
J
J
Niederdellmann
H
H
Hofstädter
F
F
Buettner
R
R
D000328:Adult; D015295:Antigens, Tumor-Associated, Carbohydrate / Q000096:biosynthesis; D014408:Biomarkers, Tumor / Q000032:analysis; D004268:DNA-Binding Proteins / Q000096:biosynthesis* / Q000235:genetics; D003937:Diagnosis, Differential; D029721:Drosophila Proteins; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008544:Melanocytes / Q000648:ultrastructure; D008854:Microscopy, Electron; D009062:Mouth Neoplasms / Q000737:chemistry* / Q000378:metabolism / Q000473:pathology / Q000648:ultrastructure; D009363:Neoplasm Proteins / Q000096:biosynthesis*; D009364:Neoplasm Recurrence, Local; D018317:Nerve Sheath Neoplasms / Q000737:chemistry* / Q000378:metabolism / Q000473:pathology / Q000648:ultrastructure; D016133:Polymerase Chain Reaction; D011518:Proto-Oncogene Proteins / Q000096:biosynthesis* / Q000235:genetics; D051096:Proto-Oncogene Proteins c-ret; D020794:Receptor Protein-Tyrosine Kinases / Q000096:biosynthesis* / Q000235:genetics; D050656:Transcription Factor AP-2; D014157:Transcription Factors / Q000096:biosynthesis* / Q000235:genetics
D015295:Antigens, Tumor-Associated, Carbohydrate; D014408:Biomarkers, Tumor; D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; C074879:MIA antigen, human; D009363:Neoplasm Proteins; D011518:Proto-Oncogene Proteins; C493677:TFAP2B protein, human; D050656:Transcription Factor AP-2; D014157:Transcription Factors; D051096:Proto-Oncogene Proteins c-ret; D020794:Receptor Protein-Tyrosine Kinases; C416649:Ret protein, Drosophila