Presence of glycosyltransferase inhibitors in the sera of patients with long-term surviving ABO incompatible (A2 to O) kidney grafts.
In the sera of blood group O recipients with long-term surviving blood group A2 kidney grafts, inhibitors of A-glycosyltransferase (alpha-3-N-acetyl-D-galactosaminyl transferase) have been identified in four out of six patients. The inhibitors seem to be of IgG antibody nature and do not appear until at least 1 year after transplantation. The inhibitors are also active against B-transferase (alpha-3-D-galactosyl transferase) as well as against A-glycosyltransferase of pig origin. The importance of these A-glycosyltransferase inhibitors is not clear. They may have a modifying effect on the antigenic expression of the graft. The immunogenicity of soluble glycosyltransferases is well known and the development of antibodies against them might prevent their enzymatic activity.
Rydberg
L
L
Regional Blood Center, Sahlgren's Hospital, Göteborg, Sweden.
Samuelsson
B E
BE
D000017:ABO Blood-Group System; D000818:Animals; D001803:Blood Transfusion; D004791:Enzyme Inhibitors / Q000097:blood*; D004912:Erythrocytes / Q000276:immunology; D016695:Glycosyltransferases / Q000037:antagonists & inhibitors*; D006085:Graft Survival; D006801:Humans; D016030:Kidney Transplantation / Q000276:immunology; D017741:Survivors; D013552:Swine
D000017:ABO Blood-Group System; D004791:Enzyme Inhibitors; D016695:Glycosyltransferases