title: Bone microdamage and skeletal fragility in osteoporotic and stress fractures.
abstract: The accumulation of bone microdamage has been proposed as one factor that contributes to increased skeletal fragility with age and that may increase the risk for fracture in older women. This paper reviews the current status and understanding of microdamage physiology and its importance to skeletal fragility. Several questions are addressed: Does microdamage exist in vivo in bone? If it does, does it impair bone quality? Does microdamage accumulate with age, and is the accumulation of damage with age sufficient to cause a fracture? The nature of the damage repair mechanism is reviewed, and it is proposed that osteoporotic fracture may be a consequence of a positive feedback between damage accumulation and the increased remodeling space associated with repair.
authors.affiliation: Department of Anatomy, Biomechanics and Biomaterials Research Center, Indiana University School of Medicine, Indianapolis 46202, U.S.A.
authors.forename: D B
authors.initials: DB
authors.lastname: Burr
authors.forename: M R
authors.initials: MR
authors.lastname: Forwood
authors.forename: D P
authors.initials: DP
authors.lastname: Fyhrie
authors.forename: R B
authors.initials: RB
authors.lastname: Martin
authors.forename: M B
authors.initials: MB
authors.lastname: Schaffler
authors.forename: C H
authors.initials: CH
authors.lastname: Turner
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000473:pathology; D001696:Biomechanical Phenomena; D015519:Bone Density / Q000502:physiology*; D001842:Bone and Bones / Q000473:pathology* / Q000503:physiopathology / Q000648:ultrastructure; D005260:Female; D015775:Fractures, Stress / Q000453:epidemiology / Q000209:etiology* / Q000503:physiopathology; D006801:Humans; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000150:complications / Q000473:pathology* / Q000503:physiopathology; D016062:Porosity; D018570:Risk Assessment