title: Body composition changes measured by dual-energy X-ray absorptiometry in patients receiving home parenteral nutrition.
abstract: BACKGROUND
  To monitor changes in body composition in patients receiving home parenteral nutrition (HPN) and to ascertain whether changes were related to the amount of energy supplied by HPN, we studied prospectively patients with gut failure maintained on HPN.
  
  
  METHODS
  Patients were subjected to repeated measurement of body composition by dual-energy X-ray absorptiometry (DXA), the second investigation being performed after a mean period of 20 (range, 11-26) months. Thirty-two patients were included, one patient was excluded, and five patients died during the study period. At inclusion, the patients had received HPN for a mean period of 30 (range, 6-216) months. The indication for HPN was inflammatory bowel disease (n = 16), abdominal cancers (n = 5), and scleroderma and others (n = 11). The fat-free mass (FFM), fat mass (FM), and total body mineral content (TBMC) were measured by DXA.
  
  
  RESULTS
  Mean body mass index decreased from 21.18 to 20.96 kg/m2 (P = 0.36). The mean FFM showed a small, insignificant increase to 37.68 kg (P = 0.71). Mean TBMC was unchanged at 2.28 kg, and mean FM decreased from 19.25 to 18.17 kg (P = 0.055). During the study period the mean daily energy supply by HPN was reduced from kcal 1195 to kcal 959 (P = 0.004). There was a direct positive correlation between the individual changes in HPN energy supply and body weight and FFM (r = 0.437, r = 0.410, P < 0.05).
  
  
  CONCLUSIONS
  The body composition of HPN patients was stable, with no change in mean FFM, FM, or TBMC. Individual changes in body weight and FFM correlated with change in HPN energy supply.
authors.affiliation: Dept. of Gastroenterology CA, Rigshospitalet, University of Copenhagen, Denmark.
authors.forename: L
authors.initials: L
authors.lastname: Tjellesen
authors.forename: M
authors.initials: M
authors.lastname: Staun
authors.forename: P K
authors.initials: PK
authors.lastname: Nielsen
mesh_terms: D015502:Absorptiometry, Photon; D001823:Body Composition; D001835:Body Weight; D002149:Energy Intake; D005526:Food, Formulated; D006801:Humans; D016562:Parenteral Nutrition, Home Total; D011446:Prospective Studies; D012778:Short Bowel Syndrome / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000628:therapy*; D013997:Time Factors