title: Antiseptic-impregnated central venous catheters reduce the incidence of bacterial colonization and associated infection in immunocompromised transplant patients.
abstract: The incidence of bacterial colonization of central venous catheters using a standard polyurethane catheter was compared with that using an antiseptic (silver sulphadiazine and chlorhexidine) impregnated catheter in a group of patients with thoracic organ transplantation. Colonization was reduced from 25 of 35 standard catheters to 10 of 44 study catheters (P < 0.002), a 68% reduction. Similarly, the incidence of concomitant infection, by the same organism at another site was reduced from 10 of 35 standard catheters to 4 of 44 study catheters (P < 0.03), a 63% reduction.
authors.affiliation: Department of Anaesthesia, St George's Hospital, London, UK.
authors.forename: S J
authors.initials: SJ
authors.lastname: George
authors.forename: P
authors.initials: P
authors.lastname: Vuddamalay
authors.forename: M J
authors.initials: MJ
authors.lastname: Boscoe
mesh_terms: D000328:Adult; D001424:Bacterial Infections / Q000382:microbiology / Q000517:prevention & control*; D002405:Catheterization, Central Venous / Q000295:instrumentation*; D002710:Chlorhexidine / Q000494:pharmacology; D004202:Disinfectants / Q000494:pharmacology*; D004203:Disinfection; D005260:Female; D006801:Humans; D007165:Immunosuppression Therapy; D008297:Male; D008875:Middle Aged; D016377:Organ Transplantation; D012837:Silver Sulfadiazine / Q000494:pharmacology
chemical_list: D004202:Disinfectants; D002710:Chlorhexidine; D012837:Silver Sulfadiazine