title: Acute megakaryoblastic leukaemia in a patient with systemic lupus erythematosus.
abstract: We describe here a 72-year-old female patient with an acute megakaryoblastic leukaemia (M7 by FAB Classification) and systemic lupus erythematosus (SLE). The patient had not been pretreated with immunosuppressive therapy, which is potentially leukaemogenic. The karyotype displayed multiple, structural and numerical anomalies, suggesting a possible de novo rather than a secondary nature of leukaemia.
authors.affiliation: Institute of Hematology, Clinical Center of Serbia, Belgrade, Yugoslavia.
authors.forename: M
authors.initials: M
authors.lastname: Colović
authors.forename: G
authors.initials: G
authors.lastname: Janković
authors.forename: V
authors.initials: V
authors.lastname: Lazarević
authors.forename: A
authors.initials: A
authors.lastname: Novak
mesh_terms: D000368:Aged; D001853:Bone Marrow / Q000473:pathology; D002869:Chromosome Aberrations / Q000473:pathology; D025063:Chromosome Disorders; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007621:Karyotyping; D007947:Leukemia, Megakaryoblastic, Acute / Q000150:complications* / Q000235:genetics / Q000473:pathology; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000473:pathology; D008533:Megakaryocytes / Q000473:pathology