Lower extremity macrovascular disease in diabetes.
Lower extremity macrovascular disease is more common and progresses more rapidly in the presence of diabetes and has a characteristic peritibial distribution with sparing of the foot arteries. The biology of the diabetic foot is compromised, thereby making it more susceptible to injury. Hence, compromises in perfusion have a greater significance, warranting an aggressive approach to revascularization.
Arora
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S
Beth Israel Medical Center, Harvard Medical School, Boston, MA, USA.
LoGerfo
F W
FW
D001157:Arterial Occlusive Diseases / Q000150:complications / Q000628:therapy; D001161:Arteriosclerosis / Q000150:complications / Q000503:physiopathology; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000503:physiopathology; D017719:Diabetic Foot / Q000503:physiopathology; D003929:Diabetic Neuropathies / Q000503:physiopathology; D006801:Humans; D007866:Leg; D012039:Regional Blood Flow; D014652:Vascular Diseases / Q000150:complications* / Q000503:physiopathology