title: Assay of antibiotic susceptibility of Chlamydia pneumoniae.
abstract: It is well known that treatment of Chlamydia pneumoniae infections is difficult. High doses and prolonged treatment is often needed to achieve clinical cure despite good in vitro effect of the drugs used. We here discuss different methodological problems in the determination of MIC and MBC values of C. pneumoniae. The length of the preincubation time and the lack of fluctuation of the antibiotic concentrations may affect the outcome of the currently used assay.
authors.affiliation: Department of Infectious Diseases, University Hospital, Uppsala, Sweden.
authors.forename: E
authors.initials: E
authors.lastname: Hjelm
authors.forename: K
authors.initials: K
authors.lastname: Hultén
authors.forename: C
authors.initials: C
authors.lastname: Nyström-Rosander
authors.forename: I
authors.initials: I
authors.lastname: Gustafsson
authors.forename: L
authors.initials: L
authors.lastname: Engstrand
authors.forename: O
authors.initials: O
authors.lastname: Cars
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D016993:Chlamydophila pneumoniae / Q000187:drug effects*; D008826:Microbial Sensitivity Tests
chemical_list: D000900:Anti-Bacterial Agents