title: [T2*-contrast perfusion study--principles, theory and clinical utility in evaluating cerebral hemodynamics].
abstract: Contrast-enhanced dynamic study is easily feasible with a clinical MR system, for evaluating cerebral perfusion. A bolus of the paramagnetic contrast agents such as Gd-DTPA produces inhomogenity of the regional magnetic field between the capillaries and extravascular proton, and causes a decrease of signal intensity in the perfused region with T2*-weighted sequences. Echo planar imaging (EPI) is suitable for contrast-enhanced dynamic study, because it is markedly susceptible and provides high temporal-resolution. Tracer kinetic approaches are used for analysis of the dynamic data to acquire various perfusion parameters such as time delta R2* curve, rCBF, rCBV and MTT. T2*-weighted contrast-enhanced perfusion imaging is useful, especially, for detecting hyperacute ischemia and its therapeutic window, and depicting vasculature and ability of the brain tumors.
authors.affiliation: Department of Radiology, Tokyo Metropolitan Ebara Hospital.
authors.forename: M
authors.initials: M
authors.lastname: Ida
authors.forename: M
authors.initials: M
authors.lastname: Yamashita
authors.forename: S
authors.initials: S
authors.lastname: Shimizu
authors.forename: Y
authors.initials: Y
authors.lastname: Kurisu
mesh_terms: D001783:Blood Flow Velocity; D001810:Blood Volume; D001927:Brain Diseases / Q000503:physiopathology; D002560:Cerebrovascular Circulation; D017352:Echo-Planar Imaging; D005682:Gadolinium; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D004369:Pentetic Acid
chemical_list: D004369:Pentetic Acid; D005682:Gadolinium