The potential of combinatorial peptide libraries for the identification of inhibitors of TNF-alpha mediated cytotoxicity in vitro.
The use of random peptide libraries has recently received considerable attention as a new tool for identifying novel therapeutic molecules. The libraries represent an enormous number of peptide sequence displayed either on the virion surface of filamentous phage clones or on a solid phase synthetic support. In this minireview we summarize our recent findings on the use of combinatorial peptide libraries to identify antagonists of the biological activities of TNF-alpha, a cytokine which plays a key role in immune and inflammatory responses.
Partidos
C D
CD
Royal Veterinary College, Department of Pathology and Infectious Diseases, London, UK. hpartido@rvc.ac.uk
Chirinos-Rojas
C L
CL
Steward
M W
MW
D000818:Animals; D001435:Bacteriophages; D005822:Genetic Vectors; D006801:Humans; D019151:Peptide Library; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors*
D019151:Peptide Library; D014409:Tumor Necrosis Factor-alpha