title: Etiology of acute non-A, B, C hepatitis in Thai patients: preliminary study.
abstract: To better characterize the etiology of acute non-A, B, C hepatitis, 24 sera from 50 acute hepatitis without acute markers for hepatitis A, B, and C were examined for acute markers for the hepatitis E virus (HEV), cytomegalovirus (CMV), herpes simplex virus type 2 (HSV-2), and Epstein-Barr virus. Immunoglobulin M (IgM) specific for HEV, HSV-2, and CMV was detected using ELISA and total Ig specific to EBV was determined by standard indirect immunofluorescence. IgM to CMV was not observed in sera from any of the patients; whereas, IgM to HEV was detected in sera from 2 patients and IgM to HSV-2 was detected in 5 of 24 acute hepatitis patients. In addition, high titer of antibody was found in 2 of the patients. This results indicate that HSV-2 and HEV circulate in Thailand and are responsible for a small proportion of non-A, B, C hepatitis in Thailand.
authors.affiliation: Faculty of Tropical Medicine, Mahidol University, Thailand.
authors.forename: Y
authors.initials: Y
authors.lastname: Maneerat
authors.forename: P
authors.initials: P
authors.lastname: Wilairatana
authors.forename: E
authors.initials: E
authors.lastname: Pongponratn
authors.forename: U
authors.initials: U
authors.lastname: Chaisri
authors.forename: P
authors.initials: P
authors.lastname: Puthavatana
authors.forename: R
authors.initials: R
authors.lastname: Snitbhan
authors.forename: B
authors.initials: B
authors.lastname: Raengsakulrach
authors.forename: E T
authors.initials: ET
authors.lastname: Clayson
authors.forename: D W
authors.initials: DW
authors.lastname: Vaughn
authors.forename: S
authors.initials: S
authors.lastname: Kurathong
authors.forename: S
authors.initials: S
authors.lastname: Pramoolsinsup
authors.forename: A
authors.initials: A
authors.lastname: Juthaputhi
mesh_terms: D006508:Hepatitis Antibodies / Q000276:immunology; D016751:Hepatitis E / Q000209:etiology* / Q000276:immunology; D006801:Humans; D013785:Thailand
chemical_list: D006508:Hepatitis Antibodies