title: Cytogenetic support for early malignant change in a diffuse neurofibroma not associated with neurofibromatosis.
abstract: A 62-year-old woman presented with a solitary diffuse neurofibroma; a second recurrence showed features indicative of malignancy, but insufficient for a certain histologic diagnosis. Cytogenetic analysis revealed abnormalities previously described in malignant peripheral nerve sheath tumors and not in their benign counterparts, thus supporting the histologic suspicion of emerging malignancy.
authors.affiliation: Department of Pathology, University Hospital, Groningen, The Netherlands.
authors.forename: W M
authors.initials: WM
authors.lastname: Molenaar
authors.forename: T
authors.initials: T
authors.lastname: Dijkhuizen
authors.forename: J
authors.initials: J
authors.lastname: van Echten
authors.forename: H J
authors.initials: HJ
authors.lastname: Hoekstra
authors.forename: E
authors.initials: E
authors.lastname: van den Berg
mesh_terms: D002869:Chromosome Aberrations; D005260:Female; D006801:Humans; D007621:Karyotyping; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009455:Neurofibroma / Q000235:genetics* / Q000473:pathology; D012303:Ring Chromosomes; D012983:Soft Tissue Neoplasms / Q000235:genetics* / Q000473:pathology; D014178:Translocation, Genetic