title: 1,3-Dimethylisoguanine, a new purine from the marine sponge Amphimedon viridis.
abstract: A new purine, 1,3-dimethylisoguanine (1), has been isolated from the marine sponge Amphimedon viridis and identified by analysis of spectroscopic data. Compound 1 increased the contractions obtained by transmural electrical stimulation in the guinea pig longitudinal muscle/myenteric plexus in a dose-dependent manner.
authors.affiliation: Instituto de Química de São Carlos, Universidade de São Paulo, Brazil.
authors.forename: C C
authors.initials: CC
authors.lastname: Chehade
authors.forename: R L
authors.initials: RL
authors.lastname: Dias
authors.forename: R G
authors.initials: RG
authors.lastname: Berlinck
authors.forename: A G
authors.initials: AG
authors.lastname: Ferreira
authors.forename: L V
authors.initials: LV
authors.lastname: Costa
authors.forename: M
authors.initials: M
authors.lastname: Rangel
authors.forename: E L
authors.initials: EL
authors.lastname: Malpezzi
authors.forename: J C
authors.initials: JC
authors.lastname: de Freitas
authors.forename: E
authors.initials: E
authors.lastname: Hajdu
mesh_terms: D000818:Animals; D004558:Electric Stimulation; D006147:Guanine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006168:Guinea Pigs; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects / Q000502:physiology; D011161:Porifera / Q000737:chemistry*
chemical_list: C107720:1,3-dimethylisoguanine; D006147:Guanine