title: Fine needle aspiration biopsy vs. ultrasound-guided transrectal random core biopsy of the prostate. Comparative investigations in 246 cases.
abstract: OBJECTIVE
  To compare fine needle aspiration biopsy (FNAB) and ultrasound-guided transrectal core biopsy of the prostate.
  
  
  METHODS
  FNAB and the random core biopsy were performed simultaneously on 246 patients who either had striking palpable signs or increased levels of prostate-specific antigen, at least 5 micrograms/mL, on two separate examinations over a six-week period,
  
  
  RESULTS
  The histologic and cytologic evaluations showed very close conformity between the two methods. Fifty-eight percent of the patients had benign prostate hyperplasia. Of the total number of patients, 103 (42%) had prostate carcinoma. This figure was confirmed in 101 (98%) of cases using FNAB. In two cases (0.8%) atypical prostate hyperplasia was diagnosed. In five cases the examination had to be repeated since insufficient prostate cell material was collected. Ultrasound-guided random core biopsy showed the presence of carcinoma in 96 of 103 patients (93%). It was necessary to repeat the examination in one patient due to a lack of adequate cell material.
  
  
  CONCLUSIONS
  In our hands, FNAB method has a sensitivity of 98%, whereas core biopsy attained 91%. Both methods showed 100% concurrence in specificity.
authors.affiliation: Department of Urology, Virchow Medical Center, Humboldt University, Berlin, Germany.
authors.forename: H
authors.initials: H
authors.lastname: al-Abadi
mesh_terms: D001706:Biopsy; D001707:Biopsy, Needle / Q000379:methods; D003581:Cytodiagnosis / Q000379:methods; D006801:Humans; D008297:Male; D011470:Prostatic Hyperplasia / Q000473:pathology; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D012680:Sensitivity and Specificity; D014463:Ultrasonography