In vitro evaluation of antifungal properties of 8.O.4'-neolignans.
Eighteen racemic 8.O.4'-neolignans with six different substitution patterns in rings A and B, in their ketone and in their erythro and threo alcoholic forms, were evaluated for antifungal activity by the agar dilution method. Only the alcohols exhibited a broad spectrum of activities against Microsporum canis, Microsporum gypseum, Tricophyton mentagrophytes, Tricophyton rubrum, and Epidermophyton floccosum. (+/-)-erythro-3,4-(methylenedioxy) -7-hydroxy-1'-allyl-3',5'-dimethoxy-8.O.4'-neolignan (11) was the most active compound in the series, and E. floccosum was the most susceptible species.
Zacchino
S
S
Area Farmacognosia, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Argentina.
Rodríguez
G
G
Pezzenati
G
G
Orellana
G
G
Enriz
R
R
Gonzalez Sierra
M
M
D000935:Antifungal Agents / Q000737:chemistry / Q000494:pharmacology*; D004821:Epidermophyton / Q000187:drug effects; D017705:Lignans / Q000737:chemistry / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D008864:Microsporum / Q000187:drug effects; D013057:Spectrum Analysis; D014249:Trichophyton / Q000187:drug effects
D000935:Antifungal Agents; D017705:Lignans