Endothelins and cardiac hypertrophy.
Cardiac hypertrophy is a commonly observed complication of a variety of cardiovascular diseases. As well as mechanical stresses such as pressure overload, several humoral factors may contribute to the development of cardiac hypertrophy. In the early 1990s, endothelin-1 (ET-1) was found to induce cardiomyocyte hypertrophy in cultured neonatal rat cardiomyocytes. Furthermore, evidence is accumulating to date to support the postulate that ET-1 may function as an autocrine/paracrine factor in the development of cardiac hypertrophy in vivo as well as in vitro In this review article, I discuss physiological and pathophysiological roles of ET-1 and its related peptides in cardiac hypertrophy associated with various cardiovascular diseases.
Ito
H
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Second Department of Internal Medicine, Tokyo Medical & Dental University, Bunkyo-ku, Japan. hito.med2@med.tmd.ac.jp
D000818:Animals; D006332:Cardiomegaly; D002478:Cells, Cultured; D019332:Endothelin-1 / Q000494:pharmacology / Q000502:physiology*; D006801:Humans; D051381:Rats
D019332:Endothelin-1