Effects of adrenomedullin on rat cerebral arterioles.
The effects of adrenomedullin on isolated rat intracerebral arterioles were investigated and compared with those of calcitonin gene-related peptide (CGRP) and amylin. Adrenomedullin produced dose-dependent vasodilation (maximum dilation 27.1 +/- 2.1% at 3 x 10(-7) M, median effective dose (EC50)) 1.6 x 10(-9) M). CGRP produced similar vasodilation (19.8 +/- 4.1%) at 10(-7) M with a lower EC50 of 2.8 x 10(-11) M. Amylin did not cause vasodilation at concentrations up to 10(-6) M. Adrenomedullin-induced vasodilation was significantly suppressed by CGRP-(8-37). These data suggest that adrenomedullin is a potent vasodilator for arterioles in the cerebral microcirculation that acts through CGRP receptors.
Mori
Y
Y
Department of Neurosurgery, Nagoya University School of Medicine, Showa, Japan.
Takayasu
M
M
Suzuki
Y
Y
Shibuya
M
M
Yoshida
J
J
Hidaka
H
H
D053607:Adrenomedullin; D000682:Amyloid / Q000494:pharmacology; D000818:Animals; D001160:Arterioles / Q000187:drug effects; D001921:Brain / Q000098:blood supply*; D015740:Calcitonin Gene-Related Peptide / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D058228:Islet Amyloid Polypeptide; D009119:Muscle Contraction / Q000187:drug effects; D010446:Peptide Fragments / Q000494:pharmacology; D010455:Peptides / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014664:Vasodilation / Q000187:drug effects; D014665:Vasodilator Agents / Q000494:pharmacology*
D000682:Amyloid; D058228:Islet Amyloid Polypeptide; D010446:Peptide Fragments; D010455:Peptides; D014665:Vasodilator Agents; C058636:calcitonin gene-related peptide (8-37); D053607:Adrenomedullin; D015740:Calcitonin Gene-Related Peptide