title: Ca2+-dependent regulation in neuronal gene expression.
abstract: Ca2+ is an important signal-transduction molecule that plays a role in many intracellular signaling pathways. Recent advances have indicated that in neurons, Ca2+-controlled signaling mechanisms cooperate in order to discriminate amongst incoming cellular inputs. Ca2+-dependent transcriptional events can thereby be made selectively responsive to bursts of synaptic activity of specific intensity or duration.
authors.affiliation: Department of Pharmacology, Kyoto University Faculty of Medicine, Sakyo-ku, Kyoto 606-01, Japan. hbito@mfour.med.kyoto-u.ac.jp
authors.forename: H
authors.initials: H
authors.lastname: Bito
authors.forename: K
authors.initials: K
authors.lastname: Deisseroth
authors.forename: R W
authors.initials: RW
authors.lastname: Tsien
mesh_terms: D000818:Animals; D002118:Calcium / Q000502:physiology*; D015870:Gene Expression / Q000235:genetics*; D006624:Hippocampus / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism* / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology
chemical_list: D002118:Calcium