title: Serologic evidence of Jamestown Canyon virus infection in white-tailed deer populations from Connecticut.
abstract: We determined the prevalence and distribution of Jamestown Canyon (JC) virus antibody in white-tailed deer (Odocoileus virginianus) populations in Connecticut, USA. Sera were collected from hunter-killed deer during 1993. Antibody to JC virus was detected by enzyme-linked immunosorbent assay (ELISA) in 92 (21%) of 446 deer sera, and was uniformly distributed among geographic sites. Twenty-one ELISA-positive sera were tested and confirmed positive by plaque reduction neutralization testing. This represents the first serologic evidence of JC virus in a reservoir host population from the northeastern United States. No cross-reactivity was seen with California encephalitis, Keystone, or snowshoe hare viruses, but a varying degree of cross-reactivity was obtained with Guaroa, Jerry Slough, La-Crosse, San Angelo, and trivittatus viruses. We conclude from this investigation and previous isolations of JC virus from mosquitoes in the state that JC virus occurs enzootically in Connecticut.
authors.affiliation: Yale Arbovirus Research Unit, Yale University School of Medicine, New Haven, Connecticut 06520, USA.
authors.forename: J M
authors.initials: JM
authors.lastname: Zamparo
authors.forename: T G
authors.initials: TG
authors.lastname: Andreadis
authors.forename: R E
authors.initials: RE
authors.lastname: Shope
authors.forename: S J
authors.initials: SJ
authors.lastname: Tirrell
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000097:blood*; D003237:Connecticut / Q000453:epidemiology; D003429:Cross Reactions; D003670:Deer; D002141:Encephalitis Virus, California / Q000276:immunology*; D004670:Encephalitis, California / Q000453:epidemiology / Q000662:veterinary*; D004797:Enzyme-Linked Immunosorbent Assay / Q000662:veterinary; D015995:Prevalence; D016036:Seroepidemiologic Studies
chemical_list: D000914:Antibodies, Viral