Isolation of a new Orientia tsutsugamushi serotype.
Orientia tsutsugamushi, the etiological agent of scrub typhus, is an antigenically diverse organism and many serologically distinct strains have been identified. The 56 kDa protein of O. tsutsugamushi, a major protein in the outer membrane, has been thought to be responsible for this antigenic variability. A strain of O. tsutsugamushi isolated in Korea cross-reacted with both Gilliam strain-specific and Karp strain-specific monoclonal antibodies. When its 56 kDa protein gene was cloned and analyzed, its sequence showed variation especially between 1,200 and 1,250 bp, showing that this isolate is a new O. tsutsugamushi strain.
Seong
S Y
SY
Department of Microbiology, Seoul National University College of Medicine, Republic of Korea.
Park
S G
SG
Kim
H R
HR
Han
T H
TH
Kang
J S
JS
Choi
M S
MS
Kim
I S
IS
Chang
W H
WH
D000595:Amino Acid Sequence; D000907:Antibodies, Bacterial; D000911:Antibodies, Monoclonal; D000918:Antibody Specificity; D000940:Antigenic Variation; D000942:Antigens, Bacterial / Q000235:genetics* / Q000276:immunology; D001425:Bacterial Outer Membrane Proteins / Q000235:genetics* / Q000276:immunology; D001483:Base Sequence; D005798:Genes, Bacterial; D006801:Humans; D007723:Korea; D008969:Molecular Sequence Data; D012285:Orientia tsutsugamushi / Q000145:classification* / Q000235:genetics* / Q000276:immunology; D016133:Polymerase Chain Reaction; D012612:Scrub Typhus / Q000382:microbiology*; D017422:Sequence Analysis, DNA; D017386:Sequence Homology, Amino Acid; D012703:Serotyping
D000907:Antibodies, Bacterial; D000911:Antibodies, Monoclonal; D000942:Antigens, Bacterial; D001425:Bacterial Outer Membrane Proteins