title: Effect of dexmedetomidine on lumbar cerebrospinal fluid pressure in humans.
abstract: Dexmedetomidine's potential for analgesia without respiratory depression and its opioid- and anesthetic-sparing properties make it an attractive choice as an anesthetic adjunct for patients undergoing neurosurgery. However, the effects of dexmedetomidine on intracranial pressure are not known. We therefore studied the effect of dexmedetomidine on lumbar cerebrospinal fluid (CSF) pressure in patients after transphenoidal pituitary tumor surgery. Sixteen transphenoidal pituitary tumor surgery patients were randomized to receive placebo (n = 9) or dexmedetomidine (n = 7) for 60 min in the postanesthesia care unit. The study drug was administered by a continuous computer-controlled infusion to achieve an estimated plasma dexmedetomidine concentration of 600 pg/mL, the highest plasma concentration that has been used for clinical purposes. Patient-controlled analgesia was used to administer morphine for postoperative discomfort. Lumbar CSF pressure (via lumbar intrathecal catheter), intraarterial blood pressure, and heart rate were monitored continuously. There was no change in lumbar CSF pressure in either group. The highest values obtained were 19 mm Hg in the dexmedetomidine group and 20 mm Hg in the placebo group. During infusion, mean arterial pressure decreased from 103 +/- 10 mm Hg to 86 +/- 6 mm Hg (P < 0.05), heart rate decreased from 77 +/- 12 bpm to 64 +/- 7 bpm (P < 0.05), and cerebral perfusion pressure decreased from 95 +/- 8 mm Hg to 78 +/- 6 mm Hg (P < 0.05) in the dexmedetomidine group, but not in the placebo group. We conclude that dexmedetomidine does not have an effect on lumbar CSF pressure in patients with normal intracranial pressure who have undergone transphenoidal pituitary hypophysectomy.
  
  
  CONCLUSIONS
  The effects of dexmedetomidine (an alpha2-agonist) or placebo on lumbar cerebrospinal fluid pressure, measured via an intrathecal catheter, were studied postoperatively in 16 patients. Dexmedetomidine had no effect on lumbar cerebrospinal fluid pressure. We will continue to investigate the potential utility of dexmedetomidine for neurosurgical anesthesia.
authors.affiliation: Department of Anesthesia, University of California, San Francisco 94143-0648, USA. pekka_talke@quickmail.ucsf.edu
authors.forename: P
authors.initials: P
authors.lastname: Talke
authors.forename: C
authors.initials: C
authors.lastname: Tong
authors.forename: H W
authors.initials: HW
authors.lastname: Lee
authors.forename: J
authors.initials: J
authors.lastname: Caldwell
authors.forename: J C
authors.initials: JC
authors.lastname: Eisenach
authors.forename: C A
authors.initials: CA
authors.lastname: Richardson
mesh_terms: D000759:Adjuvants, Anesthesia / Q000097:blood / Q000627:therapeutic use*; D000293:Adolescent; D000316:Adrenergic alpha-Agonists / Q000097:blood / Q000627:therapeutic use*; D000328:Adult; D016058:Analgesia, Patient-Controlled; D018712:Analgesics, Non-Narcotic / Q000097:blood / Q000627:therapeutic use*; D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000627:therapeutic use; D000771:Anesthesia, Intravenous; D001794:Blood Pressure / Q000187:drug effects; D015170:Cerebrospinal Fluid Pressure / Q000187:drug effects*; D004311:Double-Blind Method; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007016:Hypophysectomy / Q000379:methods; D007093:Imidazoles / Q000097:blood / Q000627:therapeutic use*; D007260:Infusion Pumps; D007262:Infusions, Intravenous; D007427:Intracranial Pressure / Q000187:drug effects; D008297:Male; D020926:Medetomidine; D008875:Middle Aged; D009020:Morphine / Q000008:administration & dosage / Q000627:therapeutic use; D010911:Pituitary Neoplasms / Q000601:surgery; D010919:Placebos; D013100:Sphenoid Bone / Q000601:surgery
chemical_list: D000759:Adjuvants, Anesthesia; D000316:Adrenergic alpha-Agonists; D018712:Analgesics, Non-Narcotic; D000701:Analgesics, Opioid; D007093:Imidazoles; D010919:Placebos; D009020:Morphine; D020926:Medetomidine