title: Communication between the extracellular environment, cytoplasmic signalling cascades and the nuclear cell-cycle machinery.
abstract: In the past decade, we have gained considerable insight into the identities of various cytoplasmic signal transduction cascades and the manner in which they operate in response to changes in the extracellular environment. Moreover, we have begun to understand what the key players are in cell-cycle regulation and how they, in turn, function to promote cell division. A long-standing question, however, has been how communication between signalling routes and the cell-cycle machinery occurs. This review highlights some recent observations that provide possible links between signal transduction and the cell-cycle machinery.
authors.affiliation: The Netherlands Cancer Institute, Division of Molecular Carcinogenesis, Amsterdam, The Netherlands.
authors.forename: D S
authors.initials: DS
authors.lastname: Peeper
authors.forename: R
authors.initials: R
authors.lastname: Bernards
mesh_terms: D000818:Animals; D002453:Cell Cycle; D002467:Cell Nucleus / Q000378:metabolism; D056741:Cyclin D; D016213:Cyclins / Q000235:genetics / Q000378:metabolism; D003593:Cytoplasm / Q000378:metabolism; D005786:Gene Expression Regulation; D016160:Retinoblastoma Protein / Q000378:metabolism; D015398:Signal Transduction; D018631:ras Proteins / Q000378:metabolism
chemical_list: D056741:Cyclin D; D016213:Cyclins; D016160:Retinoblastoma Protein; D018631:ras Proteins