title: Effects of job strain on helper-inducer (CD4+CD29+) and suppressor-inducer (CD4+CD45RA+) T cells in Japanese blue-collar workers.
abstract: BACKGROUND
  The effects of job strain on helper-inducer (CD4+CD29+) T cells and suppressor-inducer (CD4+CD45RA+) T cells are not clear.
  
  
  METHODS
  The subjects were 65 male blue-collar workers in a chemical plant in Japan. Perceived job stressors were assessed using the Japanese version of Job Content Questionnaire, i.e., job demands, job control, supervisor support and coworker support. Blood samples were taken from these subjects, and number and percentage of total lymphocytes were calculated for total T cells, helper (CD4+) T cells, suppressor/cytotoxic (CD8+) T cells, helper-inducer (CD4+CD29+) T cells and suppressor-inducer (CD4+CD45RA+) T cells using the double-staining fluorescence.
  
  
  RESULTS
  Job control significantly and positively correlated with number and percentage of helper-inducer (CD4+CD29+) T cells, after controlling for age, number of cigarettes per day and blood lead concentration (Spearman's partial correlation, p < 0.05), while job demands, supervisor support or coworker support did not (p > 0.05). The job strain index, i.e., the ratio of job demands to job control, significantly and negatively correlated with the percentage of helper-inducer (CD4+CD29+) T cells (p < 0.05). None of the job stress scales significantly correlated with number or percentage of suppressor-inducer (CD4+CD45RA+) T cells (p > 0.05).
  
  
  CONCLUSIONS
  It is suggested that higher job strain or lower job control is associated with a decrease in helper-inducer (CD4+CD29+) T cells in Japanese blue-collar workers.
authors.affiliation: Department of Public Health, Gifu University School of Medicine, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Kawakami
authors.forename: T
authors.initials: T
authors.lastname: Tanigawa
authors.forename: S
authors.initials: S
authors.lastname: Araki
authors.forename: A
authors.initials: A
authors.lastname: Nakata
authors.forename: S
authors.initials: S
authors.lastname: Sakurai
authors.forename: K
authors.initials: K
authors.lastname: Yokoyama
authors.forename: Y
authors.initials: Y
authors.lastname: Morita
mesh_terms: D000328:Adult; D000368:Aged; D015704:CD4 Antigens / Q000276:immunology; D006801:Humans; D019012:Integrin beta1 / Q000276:immunology; D007588:Job Satisfaction; D017493:Leukocyte Common Antigens / Q000276:immunology; D008297:Male; D008875:Middle Aged; D013315:Stress, Psychological / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D016526:Workload
chemical_list: D015704:CD4 Antigens; D019012:Integrin beta1; D017493:Leukocyte Common Antigens