title: Canine tumour suppressor gene p53--mutation in a case of adenoma of circumanal glands.
abstract: Highly conserved regions of the tumour suppressor gene p53, including the typical human tumour hot spots (codons 175, 245, 248, 249, 273 and 282), were investigated in various canine neoplasms. A mutation CGG-->TGG (arginine-->tryptophan) was detected in codon 249 in an adenoma of the circumanal gland.
authors.affiliation: Institute for Animal Breeding and Genetics, Veterinary University, Vienna, Austria.
authors.forename: B
authors.initials: B
authors.lastname: Mayr
authors.forename: W
authors.initials: W
authors.lastname: Schaffner
authors.forename: I
authors.initials: I
authors.lastname: Botto
authors.forename: M
authors.initials: M
authors.lastname: Reifinger
authors.forename: G
authors.initials: G
authors.lastname: Loupal
mesh_terms: D000236:Adenoma / Q000235:genetics / Q000662:veterinary*; D000694:Anal Gland Neoplasms / Q000235:genetics*; D000818:Animals; D001483:Base Sequence; D004283:Dog Diseases / Q000235:genetics*; D004285:Dogs / Q000235:genetics*; D016158:Genes, p53; D006801:Humans; D009154:Mutation; D017421:Sequence Analysis