Liquid-phase combinatorial synthesis: in search of small-molecule enzyme mimics.
The applications, advantages and recent advances in liquid-phase combinatorial chemistry using poly-(ethyleneglycol) as a soluble polymer support are reviewed. Our recent efforts towards the synthesis of peptide-based catalysts on polyethyleneglycol are reported. The screening of libraries of peptides for catalysis is discussed.
Vandersteen
A M
AM
Scripps Research Institute, Department of Molecular Biology, Skaggs Institute of Chemical Biology, La Jolla, CA 92037, USA.
Han
H
H
Janda
K D
KD
D001713:Biphenyl Compounds; D002384:Catalysis; D002918:Chymotrypsin / Q000737:chemistry; D005449:Fluorenes; D007700:Kinetics; D018716:Molecular Mimicry; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000737:chemistry; D019151:Peptide Library; D011092:Polyethylene Glycols; D012697:Serine Endopeptidases / Q000138:chemical synthesis* / Q000737:chemistry; D012996:Solutions; D013329:Structure-Activity Relationship
D001713:Biphenyl Compounds; D005449:Fluorenes; D009842:Oligopeptides; D019151:Peptide Library; D012996:Solutions; D011092:Polyethylene Glycols; D012697:Serine Endopeptidases; D002918:Chymotrypsin