Cytokine concentration in serum of lupus erythematosus patients: the effect on acute phase response.
In order to get a better insight into cytokine network regulation in systemic lupus erythematosus (SLE), we analyzed levels of interleukin-10 (IL-10), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), and interferon-gamma (IFN-gamma) in the sera from 36 SLE patients. Moreover, C-reactive protein (CRP), alpha-1-acid-glycoprotein (AGP), and alpha-1-antichymotripsin (ACT) serum levels were evaluated. Serum levels of IL-10 and IL-6 were significantly increased when compared with healthy controls. TNF-alpha and IFN-gamma did not differ from normal values. We established the relationship between IL-10 and IL-6 as well as between IL-10 and TNF-alpha. None of the analyzed cytokines correlated with the acute phase protein levels. Based on the obtained data, we conclude that IL-10 may play the superior regulating role in SLE. A lack of correlation between the cytokines and acute phase proteins suggests their independence from cytokine regulation.
Lacki
J K
JK
Hochrhein Institut for Rheumatism Research and Prevention, Bad Saeckingen, Germany.
Leszczynski
P
P
Kelemen
J
J
Müller
W
W
Mackiewicz
S H
SH
D000210:Acute-Phase Reaction / Q000097:blood / Q000276:immunology*; D000293:Adolescent; D000328:Adult; D002097:C-Reactive Protein / Q000378:metabolism; D016022:Case-Control Studies; D016207:Cytokines / Q000097:blood*; D005260:Female; D006801:Humans; D007371:Interferon-gamma / Q000097:blood; D016753:Interleukin-10 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009961:Orosomucoid / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism; D000514:alpha 1-Antichymotrypsin / Q000378:metabolism
D016207:Cytokines; D015850:Interleukin-6; D009961:Orosomucoid; D014409:Tumor Necrosis Factor-alpha; D000514:alpha 1-Antichymotrypsin; D016753:Interleukin-10; D007371:Interferon-gamma; D002097:C-Reactive Protein