Microangiopathy without hemolysis in a patient following allogeneic bone marrow transplantation.
Thrombotic microangiopathy (TMA) is one of the complications of bone marrow transplantation (BMT) which includes hemolytic uremic syndrome (HUS) and thrombotic thrombocytopenic purpura (TTP). Red cell fragmentation is the most consistent laboratory finding. We present a case of TMA with endothelial damage but without the signs of hemolysis. The patient was not receiving cyclosporine. Partial activation of platelets was also observed. This case represents a new form of TMA in transplant recipients.
Akiyama
H
H
Hematology Division, Tokyo Metropolitan Komagome Hospital, Bunkyo-ku, Japan.
Yoshinaga
H
H
Endou
M
M
Tanikawa
S
S
Sakamaki
H
H
Tanoue
K
K
Onozawa
Y
Y
D000328:Adult; D000741:Anemia, Aplastic / Q000628:therapy*; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008833:Microcirculation / Q000473:pathology*; D013927:Thrombosis / Q000139:chemically induced* / Q000473:pathology / Q000503:physiopathology; D014184:Transplantation, Homologous; D014652:Vascular Diseases / Q000139:chemically induced* / Q000473:pathology / Q000503:physiopathology