title: Do effector and memory T helper cells also need B7 ligand costimulatory signals?
abstract: Blocking B7 ligand-costimulatory molecules can inhibit a primary T-dependent immune response, but whether these interactions also mediate ongoing or memory immune responses is less clear. Development of immunotherapies based on blocking B7 ligand interactions would be limited if they were effective only at the initiation of an immune response. We discuss the conditions under which T helper effector and memory cells may or may not require B7 ligand interactions for their function.
authors.affiliation: Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.
authors.forename: W C
authors.initials: WC
authors.lastname: Gause
authors.forename: V
authors.initials: V
authors.lastname: Mitro
authors.forename: C
authors.initials: C
authors.lastname: Via
authors.forename: P
authors.initials: P
authors.lastname: Linsley
authors.forename: J F
authors.initials: JF
authors.lastname: Urban
authors.forename: R J
authors.initials: RJ
authors.lastname: Greenwald
mesh_terms: D000818:Animals; D018122:B7-1 Antigen / Q000502:physiology*; D007156:Immunologic Memory; D008024:Ligands; D008213:Lymphocyte Activation; D015398:Signal Transduction / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*
chemical_list: D018122:B7-1 Antigen; D008024:Ligands