Does colchicine really induce bone formation in the rodent bone marrow?
Intravenous injection of a single dose of colchicine into inbred strains of BALB/c and CFW/L1 mice and into WAG rats did not effect rapid intramedullar bone formation and resorption, as has been claimed by the research group from Tokyo Medical and Dental University [14-17]. The applied doses of colchicine arrested metaphase during the first 4 hours postadministration and were noxious for hemopoietic tissue (necrosis of bone marrow was evident in 2 and 4 day specimens), but on longitudinal, serial sections of long bones there was no evidence of stimulation of osteogenesis at any point in time (2-26-day specimens). It is postulated that the system of ectopic osteogenesis by colchicine injection is not reproducible in mice and WAG rats, and the apparently osteogenic effect of colchicine, observed by the Ogura group [14-17], was mistakenly described as congenital osteopetrosis.
Wlodarski
K H
KH
Department of Histology and Embryology, Institute of Biostructure, Medical Academy, 02-004 Warszawa, Chalubinskiego 5, Poland.
Wlodarski
P K
PK
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects*; D003078:Colchicine / Q000494:pharmacology*; D005260:Female; D005269:Femur; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009999:Ossification, Heterotopic / Q000139:chemically induced*; D051381:Rats
D003078:Colchicine