Bilateral anterior uveitis and retinal haemorrhages after administration of trimethoprim.
In this case report we present a female patient with recurrent urinary infection treated with trimethoprim/sulfamethoxazole, trimethoprim alone and ciprofloxacin. She developed adverse systemic symptoms and bilateral anterior uveitis following administration of the former two drugs, and in addition retinal haemorrhages after the use of trimethoprim. Uveitis and retinal haemorrhages are rare side effects of trimethoprim/sulfamethoxazole. To our best knowledge they have not been described as a side effect of trimethoprim alone.
Kristinsson
J K
JK
Department of Ophthalmology, University of Iceland, Landakotsspítali, Reykjavík.
Hannesson
O B
OB
Sveinsson
O
O
Thorleifsson
H
H
D000287:Administration, Topical; D000328:Adult; D000892:Anti-Infective Agents, Urinary / Q000009:adverse effects* / Q000627:therapeutic use; D002939:Ciprofloxacin / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D005938:Glucocorticoids / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D009883:Ophthalmic Solutions; D012008:Recurrence; D012166:Retinal Hemorrhage / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy; D014295:Trimethoprim / Q000009:adverse effects* / Q000627:therapeutic use; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000009:adverse effects* / Q000627:therapeutic use; D014552:Urinary Tract Infections / Q000188:drug therapy; D014606:Uveitis, Anterior / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy
D000892:Anti-Infective Agents, Urinary; D005938:Glucocorticoids; D009883:Ophthalmic Solutions; D002939:Ciprofloxacin; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D014295:Trimethoprim