Non P-glycoprotein novel proteins involved in human cancer multidrug resistance.
Multidrug resistance of cancer cells is a serious problem in the treatment of tumors and is the leading cause of the frequent failure of chemotherapy. Cancer cell chemoresistance is based on the development of several mechanisms among which one of the most important concerns the overexpression of membrane proteins to remove cytotoxic compounds from the cytoplasm. The leading archetype of these proteins is the P-glycoprotein, a member of the ATP-binding cassette (ABC) superfamily of transporters, or traffic ATPases. In the recent past years, new non P-glycoprotein membrane proteins, several of which being members of the ABC superfamily of transporters, and new genes, have been discovered in cancer cells with a multiple drug resistance phenotype. In this article, we briefly review these newly discovered entities.
Baggetto
L G
LG
Institut de biologie et chimie des protéines, UPR 412 CNRS, Lyon, France.
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000235:genetics / Q000378:metabolism; D018528:ATP-Binding Cassette Transporters / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D002874:Chromosome Mapping; D006224:Cricetinae; D018432:Drug Resistance, Multiple / Q000235:genetics; D019008:Drug Resistance, Neoplasm / Q000235:genetics; D015870:Gene Expression; D006801:Humans; D008562:Membrane Glycoproteins / Q000235:genetics / Q000378:metabolism; D051379:Mice; D009369:Neoplasms / Q000188:drug therapy; D009374:Neoplasms, Experimental / Q000188:drug therapy; D010641:Phenotype; D014407:Tumor Cells, Cultured
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D018528:ATP-Binding Cassette Transporters; D008562:Membrane Glycoproteins