Sleep-onset rapid eye movement after electroconvulsive therapy is more frequent in patients who respond less well to electroconvulsive therapy.
The response to electroconvulsive therapy (ECT) was monitored with sleep polysomnography studies (SPS) performed pre- and post-ECT, in 25 patients with major depressive disorder (MDD). Patients included in this study met research diagnostic criteria for MDD and had been free of psychotropic medication for at least 10 days before SPS were performed. We compared ECT responders and nonresponders on SPS, demographic, and clinical parameters. Many SPS parameters, regardless of the clinical response, changed significantly with ECT. The presence of delusions was significantly associated with SOREM post-ECT. The presence of sleep-onset REM periods post-ECT was associated with poor response to ECT. SPS performed during a course of ECT may help identify patients at risk of responding less well to this modality of treatment.
Grunhaus
L
L
Department of Psychiatry Sheba Medical Center, Israel.
Shipley
J E
JE
Eiser
A
A
Pande
A C
AC
Tandon
R
R
Krahn
D D
DD
Demitrack
M A
MA
Remen
A
A
Hirschmann
S
S
Greden
J F
JF
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002540:Cerebral Cortex / Q000503:physiopathology; D003702:Delusions / Q000503:physiopathology / Q000523:psychology / Q000628:therapy; D003866:Depressive Disorder / Q000503:physiopathology / Q000523:psychology / Q000628:therapy*; D004565:Electroconvulsive Therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017286:Polysomnography; D012895:Sleep, REM / Q000502:physiology*; D016896:Treatment Outcome