title: International Conference for the Development of a Consensus on the Management and Prevention of Severe Candidal Infections.
abstract: Because of the rapidly increasing incidence of serious candidal infections, a consensus conference of 22 investigators from the United States, Europe, and Japan was held to discuss strategies for the prevention and treatment of deep-organ infections caused by Candida species. Commonly asked questions concerning the management of candidal infections were selected for discussion by the participating investigators. Possible answers to the questions were developed by the investigators, who then voted anonymously for their preferences. In certain instances, unanimity or a strong consensus was the result. In all cases, the full spectrum of responses was recorded and is presented in this report. The forms of candidal infection addressed included candidemia, candiduria, hepatosplenic candidiasis (chronic systemic candidiasis), candidal endophthalmitis, and candidal peritonitis. Prevention and treatment strategies were considered for patients who have undergone surgery, for neutropenic and nonneutropenic patients, and for patients who have undergone bone marrow and solid organ transplantation. The therapeutic roles of amphotericin B (standard and lipid formulations) and the azoles were considered.
authors.affiliation: Harbor/UCLA Medical Center, Division of Infectious Diseases, St. John's Cardiovascular Research Center, Torrance, California 90502-2064, USA.
authors.forename: J E
authors.initials: JE
authors.lastname: Edwards
authors.forename: G P
authors.initials: GP
authors.lastname: Bodey
authors.forename: R A
authors.initials: RA
authors.lastname: Bowden
authors.forename: T
authors.initials: T
authors.lastname: Büchner
authors.forename: B E
authors.initials: BE
authors.lastname: de Pauw
authors.forename: S G
authors.initials: SG
authors.lastname: Filler
authors.forename: M A
authors.initials: MA
authors.lastname: Ghannoum
authors.forename: M
authors.initials: M
authors.lastname: Glauser
authors.forename: R
authors.initials: R
authors.lastname: Herbrecht
authors.forename: C A
authors.initials: CA
authors.lastname: Kauffman
authors.forename: S
authors.initials: S
authors.lastname: Kohno
authors.forename: P
authors.initials: P
authors.lastname: Martino
authors.forename: F
authors.initials: F
authors.lastname: Meunier
authors.forename: T
authors.initials: T
authors.lastname: Mori
authors.forename: M A
authors.initials: MA
authors.lastname: Pfaller
authors.forename: J H
authors.initials: JH
authors.lastname: Rex
authors.forename: T R
authors.initials: TR
authors.lastname: Rogers
authors.forename: R H
authors.initials: RH
authors.lastname: Rubin
authors.forename: J
authors.initials: J
authors.lastname: Solomkin
authors.forename: C
authors.initials: C
authors.lastname: Viscoli
authors.forename: T J
authors.initials: TJ
authors.lastname: Walsh
authors.forename: M
authors.initials: M
authors.lastname: White
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000627:therapeutic use*; D002177:Candidiasis / Q000188:drug therapy* / Q000276:immunology / Q000517:prevention & control*; D006801:Humans
chemical_list: D000935:Antifungal Agents