title: Field trial of immunization with an experimental vaccine against Mediterranean theileriosis in Spain.
abstract: Vaccines against Mediterranean theileriosis have been developed in several countries where this disease is of economic concern. Until recently, tissue culture vaccines were a suitable method for immunizing cattle and they have been widely applied with success. In Spain, Mediterranean theileriosis is an obstacle to the improvement of dairy cattle productivity. No vaccines against this disease have been applied until recently. This report concerns the field trial of an available experimental tissue culture vaccine consisting of attenuated Theileria annulata schizont infected cells from an enzootic area of Spain. The vaccinated cattle developed a typical post-vaccination immunological response and were resistent to a field challenge. They showed no clinical signs of theileriosis while 50% of the control cattle showed typical signs of the disease and two of them died (12.5% of control cattle). This vaccine may be useful to protect cattle against Mediterranean theileriosis in enzootic areas of Spain.
authors.affiliation: Departamento de Producción Animal, Centro de Investigación y Desarrollo Agrario, Junta de Andalucía, Granada, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Viseras
authors.forename: P
authors.initials: P
authors.lastname: García-Fernández
authors.forename: F J
authors.initials: FJ
authors.lastname: Adroher
mesh_terms: D000818:Animals; D000913:Antibodies, Protozoan / Q000097:blood; D002417:Cattle; D005260:Female; D009017:Morbidity; D016052:Protozoan Vaccines; D013030:Spain; D016796:Theileria annulata / Q000276:immunology; D013801:Theileriasis / Q000453:epidemiology / Q000276:immunology / Q000517:prevention & control*; D013997:Time Factors; D014611:Vaccination / Q000662:veterinary; D014613:Vaccines, Attenuated
chemical_list: D000913:Antibodies, Protozoan; D016052:Protozoan Vaccines; D014613:Vaccines, Attenuated