Molecular pathogenesis of colorectal cancer.
The enormous progress made in the identification of genes that are involved in colon carcinogenesis has provided the foundation for further understanding the biology of both normal and cancer cells and for targeted therapeutic strategies. In one sense, the genes described in this review are only the building blocks of a larger puzzle that constitutes the integrated metabolic function of a cell. The current challenge is to understand the functional role of these genes in normal cellular physiology and make the connections between pathways that knit together integrated cellular homeostasis. A complete understanding of the regulatory pathways, and the synthesis and modifications of the proteins involved, will provide novel targets for therapeutic agents.
Hoops
T C
TC
Department of Medicine, University of Pennsylvania, Philadelphia, USA.
Traber
P G
PG
D000236:Adenoma / Q000235:genetics; D002277:Carcinoma / Q000235:genetics; D015179:Colorectal Neoplasms / Q000235:genetics*; D015972:Gene Expression Regulation, Neoplastic; D017491:Genes, APC / Q000235:genetics; D016163:Genes, DCC / Q000235:genetics; D017431:Genes, MCC / Q000235:genetics; D016147:Genes, Tumor Suppressor / Q000235:genetics*; D016158:Genes, p53 / Q000235:genetics; D006801:Humans; D018960:Hyaluronan Receptors / Q000235:genetics; D009154:Mutation; D015398:Signal Transduction
D018960:Hyaluronan Receptors