title: The effects of hypertonic saline in healthy and diseased animals.
abstract: In this review, the pharmacological effects of administering hypertonic solutions to both healthy animals and during experimentally induced diseases are considered with a view to understanding the mechanisms behind the possible clinical efficacy of such treatment. The review focuses successively on haemorrhagic shock, endotoxic shock and hypokalaemic metabolic alkalosis. How hypertonic saline solutions affect oxygen transport by haemoglobin is also considered.
authors.affiliation: Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Liège, Belgium.
authors.forename: C
authors.initials: C
authors.lastname: Cambier
authors.forename: V
authors.initials: V
authors.lastname: Ratz
authors.forename: F
authors.initials: F
authors.lastname: Rollin
authors.forename: A
authors.initials: A
authors.lastname: Frans
authors.forename: T
authors.initials: T
authors.lastname: Clerbaux
authors.forename: P
authors.initials: P
authors.lastname: Gustin
mesh_terms: D000471:Alkalosis / Q000628:therapy / Q000662:veterinary*; D000820:Animal Diseases / Q000503:physiopathology / Q000628:therapy*; D000818:Animals; D002320:Cardiovascular Physiological Phenomena; D006454:Hemoglobins / Q000502:physiology; D010101:Oxygen Consumption / Q000502:physiology; D012462:Saline Solution, Hypertonic / Q000627:therapeutic use*; D012771:Shock, Hemorrhagic / Q000628:therapy / Q000662:veterinary*; D012772:Shock, Septic / Q000628:therapy / Q000662:veterinary*; D014553:Urinary Tract Physiological Phenomena
chemical_list: D006454:Hemoglobins; D012462:Saline Solution, Hypertonic