Increased incidence of non-transitional cell carcinoma of the bladder in women of the Texas Gulf Coast region.
The objective of our study was to verify a suspected increased incidence of non-transitional cell carcinoma (TCC) of the bladder in female patients treated at our institution. The study included 169 patients, 83% of whom resided in the Texas Gulf Coast region. Tumors were considered TCC or non-TCC on the basis of their predominant histologic pattern. The incidence of non-TCC among men (8.1%) was comparable with data from American tumor registries and European studies. In contrast, our female patients exhibited a marked increased incidence of non-TCC (42.3%), which is approximately five times higher than that in other series. All male and female patients with non-TCC had invasive disease. History of urinary tract infections was strongly associated with non-TCC. Our results suggest that our sample of the female population in the Texas Gulf Coast region has a significantly high incidence of non-TCC. This unusual trend merits further investigation.
Orihuela
E
E
Department of Surgery, University of Texas Medical Branch at Galveston 77555-0540, USA.
West
D C
DC
Pow-Sang
M
M
Warren
M M
MM
D000230:Adenocarcinoma / Q000453:epidemiology; D017677:Age Distribution; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012509:Sarcoma / Q000453:epidemiology; D017678:Sex Distribution; D013781:Texas / Q000453:epidemiology; D001749:Urinary Bladder Neoplasms / Q000453:epidemiology*