The effect of 3-acetylpyridine on inferior olivary neuron degeneration in Lurcher mutant and wild-type mice.
Lurcher mutant and wild-type mice were given intraperitoneal injections of 3-acetylpyridine to look at the toxic effects of this drug on the inferior olivary neurons. Intraperitoneal administration of 3-acetylpyridine is characterized by the different sensitivity of inferior olivary neurons in Lurcher mutant and wild-type mice. Lurcher mutants suffered a destruction of these neurons while wild-type mice were unaffected. The results show that there is a different effect of 3-acetylpyridine between genetic mutations and wild-type mice on the same inbred strain of mice. The different affinity of 3-acetylpyridine for the inferior olivary neurons of this mutant is briefly discussed.
Caddy
K W
KW
Department of Physiology, University College London, UK. k.caddy@ucl.ac.uk
Vozeh
F
F
D000818:Animals; D001933:Brain Stem / Q000166:cytology / Q000187:drug effects / Q000502:physiology; D002531:Cerebellum / Q000166:cytology / Q000187:drug effects / Q000502:physiology; D005260:Female; D006579:Heterozygote; D008297:Male; D008526:Medulla Oblongata / Q000166:cytology / Q000187:drug effects / Q000502:physiology; D051379:Mice; D008809:Mice, Inbred C3H; D008818:Mice, Neurologic Mutants; D009410:Nerve Degeneration / Q000187:drug effects*; D009474:Neurons / Q000187:drug effects* / Q000502:physiology*; D009847:Olivary Nucleus / Q000187:drug effects* / Q000502:physiology*; D011689:Purkinje Cells / Q000187:drug effects / Q000502:physiology; D011725:Pyridines / Q000633:toxicity*
D011725:Pyridines; C010835:3-acetylpyridine