title: Gastric tonometry and prediction of outcome in the critically ill. Arterial to intramucosal pH gradient and carbon dioxide gradient.
abstract: Splanchnic ischaemia is thought to be of central importance in the development of multi-organ failure and hence death in critically ill patients. It has been suggested that the arterial to gastric intramucosal pH gradient and the difference in partial pressure of carbon dioxide between gastric mucosa and arterial blood are more sensitive markers of splanchnic ischaemia than gastric intramucosal pH itself and thus should be predictors of mortality in the critically ill. We studied 62 critically ill patients within 6 h of admission to the intensive care unit and found no significant difference at 0, 12 or 24 h after admission to the study in either the arterial to gastric intramucosal pH gradient or the difference in partial pressure of carbon dioxide between gastric mucosa and arterial blood between survivors and nonsurvivors. We conclude that in contrast to gastric intramucosal pH neither the arterial to gastric intramucosal pH gradient nor the difference in partial pressure of carbon dioxide between gastric mucosa and arterial blood distinguish survivors from nonsurvivors.
authors.affiliation: Department of Anaesthesia & Intensive Care, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong.
authors.forename: C D
authors.initials: CD
authors.lastname: Gomersall
authors.forename: G M
authors.initials: GM
authors.lastname: Joynt
authors.forename: K M
authors.initials: KM
authors.lastname: Ho
authors.forename: R J
authors.initials: RJ
authors.lastname: Young
authors.forename: T A
authors.initials: TA
authors.lastname: Buckley
authors.forename: T E
authors.initials: TE
authors.lastname: Oh
mesh_terms: D000328:Adult; D002245:Carbon Dioxide / Q000097:blood*; D016638:Critical Illness / Q000628:therapy*; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007511:Ischemia / Q000175:diagnosis*; D008297:Male; D008365:Manometry; D008875:Middle Aged; D010313:Partial Pressure; D011379:Prognosis; D012372:ROC Curve; D013152:Splanchnic Circulation; D015996:Survival Rate
chemical_list: D002245:Carbon Dioxide