title: Effects of repeated short versus single long episodes of focal ischemia on somatosensory evoked potentials and development of cerebral infarction in cats.
abstract: The effects of repeated short episodes of focal ischemia at 30-minute intervals or a single equivalent long episode of focal ischemia on neuronal function and development of cerebral infarction were compared using somatosensory evoked potential (SEP) recording and 2,3,5-triphenyltetrazolium chloride staining in a cat model. Seventeen cats underwent transorbital occlusion of the middle cerebral artery (MCA), using one of three procedures: sham-operation; single 1-hour occlusion of the MCA, followed by 3 hours of recirculation; or three 20-minute occlusions of the MCA at 30-minute intervals, followed by 3 hours of recirculation. Two of six cats in the single long-term occlusion group showed recovery of SEP, whereas all six cats in the repeated short-term occlusion group showed recovery of SEP at 3 hours after recirculation. All six cats in the single long-term occlusion group had cerebral infarction of various sizes, but only one cat in the repeated short-term occlusion group developed infarction. Repeated short episodes of focal ischemia are relatively less damaging than a single equivalent long episode of focal ischemia, even if the reperfusion interval is extended to 30 minutes.
authors.affiliation: Department of Neurosurgery, Yonsei University, College of Medicine, Seoul, Republic of Korea.
authors.forename: K C
authors.initials: KC
authors.lastname: Lee
authors.forename: J Y
authors.initials: JY
authors.lastname: Joo
authors.forename: J S
authors.initials: JS
authors.lastname: Huh
authors.forename: T S
authors.initials: TS
authors.lastname: Kim
mesh_terms: D000818:Animals; D002545:Brain Ischemia / Q000473:pathology / Q000503:physiopathology*; D002415:Cats; D002544:Cerebral Infarction / Q000473:pathology / Q000503:physiopathology*; D004195:Disease Models, Animal; D005073:Evoked Potentials, Somatosensory / Q000502:physiology*; D013997:Time Factors