The role of Helicobacter pylori in the pathophysiology of duodenal ulcer disease and gastric cancer.
Helicobacter pylori infection is now recognized to be an important acquired factor in the pathogenesis of duodenal ulcer disease. There is also an association between H pylori and the subsequent development of gastric cancer. The mechanism of the association between the infection and those disorders is incompletely understood but there is increasing evidence that H pylori-induced disturbances of gastric function play a pivotal role. In this article we review the role of H pylori infection in the pathophysiology of these important upper gastrointestinal diseases.
McColl
K E
KE
University Department of Medicine and Therapeutics, Western Infirmary, Glasgow, Scotland.
el-Omar
E
E
Gillen
D
D
Banerjee
S
S
D001205:Ascorbic Acid / Q000378:metabolism; D004381:Duodenal Ulcer / Q000382:microbiology / Q000503:physiopathology*; D005744:Gastric Acid / Q000378:metabolism; D005755:Gastrins / Q000502:physiology; D016481:Helicobacter Infections / Q000382:microbiology / Q000503:physiopathology*; D016480:Helicobacter pylori / Q000472:pathogenicity*; D006801:Humans; D013274:Stomach Neoplasms / Q000382:microbiology / Q000503:physiopathology*
D005755:Gastrins; D001205:Ascorbic Acid