[The effect of products of plant and microbial origin on phagocytic function and on the release of oxygen free radicals by mouse peritoneal macrophages].
The effect of in vivo stimulation with an aqueous extract obtained from roots of Symphytum officinale and Cantastim on mouse peritoneal macrophages was investigated. The results obtained showed that these products initially activated the respiratory burst of the cells and later inhibited it, activating the synthesis of catalase, SOD etc. These data suggest that macrophages challenged by various ingested antigens destroy them initially through oxygen dependent mechanisms and later through enzymatic digestion in order to retain unimpaired their epitopes.
Dolganiuc
A
A
Laboratorul de Imunologie celulară, Institutul Cantacuzino.
Radu
L D
LD
Olinescu
A
A
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005609:Free Radicals / Q000378:metabolism; D008163:Luminescent Measurements; D017737:Macrophages, Peritoneal / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism; D051379:Mice; D010100:Oxygen / Q000378:metabolism*; D010587:Phagocytosis / Q000187:drug effects*; D010743:Phospholipids; D010936:Plant Extracts / Q000494:pharmacology*; D018517:Plant Roots; D011550:Pseudomonas aeruginosa
D000276:Adjuvants, Immunologic; D005609:Free Radicals; D010743:Phospholipids; D010936:Plant Extracts; C049675:cantastim; D010100:Oxygen
Influenţa unor produşi de origine vegetală sau microbiană asupra funcţiei fagocitare şi eliberării radicalilor liberi de oxigen de către macrofagele peritoneale murine.