title: Use of jugular venous blood, compared with mixed venous blood, for measurement of venous oxygenation indices in a porcine model of endotoxic shock.
abstract: OBJECTIVE
  To evaluate the reliability of oxygen saturation and oxygen content values measured from jugular venous blood in estimating values measured from mixed venous blood during endotoxic shock.
  
  
  METHODS
  14 random-bred 10- to 15-kg Yorkshire pigs.
  
  
  METHODS
  60 pairs of heparinized blood samples were simultaneously collected from the pulmonary artery and right jugular vein during an independent study, using a porcine model of endotoxic shock. Endotoxic shock was induced by infusion of Escherichia coli endotoxin. Eighteen of the sample pairs were obtained from pigs prior to infusion of endotoxin or from control pigs. Oxygen saturation and venous oxygen content were measured by direct oximetry. Analysis of bias and precision was used to compare jugular venous blood values with values obtained from mixed venous blood. Samples from endotoxemic pigs were subclassified on the basis of abnormal states of global oxygen imbalance associated with septic shock.
  
  
  RESULTS
  Indices of venous oxygenation measured from jugular venous blood were an imprecise method of estimating values measured from mixed venous blood. There was no significant difference in bias between nonendotoxemic and endotoxemic pigs, regardless of abnormal hemodynamic states.
  
  
  CONCLUSIONS
  Jugular venous blood oxygen saturation and oxygen content values should not be used to assess global oxygen transport during endotoxic shock.
authors.affiliation: Department of Medicine, Tufts University School of Veterinary Medicine, North Grafton, MA 01536, USA.
authors.forename: J S
authors.initials: JS
authors.lastname: Wohl
authors.forename: A
authors.initials: A
authors.lastname: Baggs
authors.forename: J L
authors.initials: JL
authors.lastname: Lin
authors.forename: M P
authors.initials: MP
authors.lastname: Fink
authors.forename: N
authors.initials: N
authors.lastname: Dhupa
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001639:Bicarbonates / Q000097:blood; D001784:Blood Gas Analysis / Q000379:methods; D002245:Carbon Dioxide / Q000097:blood; D004731:Endotoxins; D004926:Escherichia coli; D007601:Jugular Veins; D010100:Oxygen / Q000097:blood*; D010101:Oxygen Consumption; D010313:Partial Pressure; D012016:Reference Values; D015203:Reproducibility of Results; D012772:Shock, Septic / Q000097:blood*; D013552:Swine; D014680:Veins
chemical_list: D001639:Bicarbonates; D004731:Endotoxins; D002245:Carbon Dioxide; D010100:Oxygen