Synthesis and biodistribution of a new 99mtechnetium fatty acid.
The synthesis and biodistribution is described for a new 99mTc-labeled fatty acid. The requisite diaminodithiol (N2S2) ligand, 9,10-bis[N-(2'-methyl-2'-mercapto)propyl] aminooctadecanoic acid, was prepared in nine steps from ethyl oleate and characterized by fast atom bombardment mass spectrometry and elemental analysis of its nickell(II) complex. The radiolabeling procedure provided a liposoluble 99mTc-labeled complex (99mTc-11) which was administered intravenously to rats concomitantly with 15-(p-[125I]-iodophenyl) pentadecanoic acid (IPPA). The myocardial profile of 99mTc-11 was inferior to that of IPPA.
Jones
G S
GS
Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA.
Elmaleh
D R
DR
Strauss
H W
HW
Fischman
A J
AJ
D000818:Animals; D005227:Fatty Acids / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D007457:Iodine Radioisotopes / Q000493:pharmacokinetics; D007462:Iodobenzenes / Q000493:pharmacokinetics; D015609:Organotechnetium Compounds / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D051381:Rats; D011916:Rats, Inbred F344; D016339:Spectrometry, Mass, Fast Atom Bombardment; D014018:Tissue Distribution
D005227:Fatty Acids; D007457:Iodine Radioisotopes; D007462:Iodobenzenes; D015609:Organotechnetium Compounds; C025391:omega-(4-iodophenyl)pentadecanoic acid