Translocation 1;19 in two brain tumors.
We report two-cases of brain tumors, one childhood medulloblastoma and one adult glioblastoma with an unusual chromosomal abnormality: a t(1;19)(q23;q13). We analyzed these karyotypes using fluorescence in situ hybridization (FISH) and wonder if this chromosomal aberration could represent a particular entity in these brain tumors like t(1;19) in ALL.
Vagner-Capodano
A M
AM
Cytogenetic Oncology laboratory, C. H. U. Timone, Marseilles, France.
Mugneret
F
F
Zattara-Cannoni
H
H
Gabert
J
J
Favre
B
B
Figarella-Branger
D
D
Gentet
J C
JC
Lena
G
G
Bernard
J L
JL
D001932:Brain Neoplasms / Q000235:genetics*; D002675:Child, Preschool; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics; D002888:Chromosomes, Human, Pair 19 / Q000235:genetics; D005260:Female; D005909:Glioblastoma / Q000235:genetics*; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D008527:Medulloblastoma / Q000235:genetics*; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D014178:Translocation, Genetic