Diabetes mellitus in childhood cystic fibrosis.
Since 1984, five patients in the cystic fibrosis (CF) clinic at Cork Regional Hospital have developed diabetes mellitus (DM) and were treated with Insulin. None had received systemic corticosteroids but two had high calorie naso-gastric feeding regimes. Two died from lung disease. A fifteen year old boy developed bilateral cataracts. In nine other paediatric CF clinics in the Republic of Ireland (total: 420 patients), three patients have DM, two receiving Insulin. Abnormal glucose tolerance is becoming more common in CF as patients survive longer. The possible role of corticosteroid treatment and intensive carbohydrate feeding regimes in development of glucose intolerance must be considered. DM in CF differs from the usual childhood DM. Regular screening and early Insulin supplementation may be beneficial.
Rauf
F
F
Department of Paediatrics, Cork University Hospital, Wilton.
O'Halloran
T
T
Watson
J B
JB
Shortt
C
C
McKiernan
J
J
D000293:Adolescent; D000328:Adult; D002648:Child; D003550:Cystic Fibrosis / Q000150:complications*; D003922:Diabetes Mellitus, Type 1 / Q000188:drug therapy*; D006801:Humans; D008297:Male