A carcinogenesis model describing mutational events at the DNA adduct level.
A stochastic carcinogenesis model is proposed to describe a sequence of component mutational changes that constitute the G:C-->A:T base substitution. This paper provides the biological basis and mathematical formulation underlying the proposed model. In addition, the paper elaborates on a numerical approach for studying the cumulant functions, survival functions, and hazard functions of the model. Several numerical examples are given of potential applications of the model.
Zheng
O
O
Division of Biometry and Risk Assessment, National Center for Toxicological Research, Jefferson, Arkansas 72079, USA.
Lutz
W K
WK
Gaylor
D W
DW
D001482:Base Composition; D002273:Carcinogens; D018736:DNA Adducts; D006801:Humans; D008962:Models, Theoretical; D009154:Mutation; D009369:Neoplasms / Q000453:epidemiology* / Q000209:etiology; D016012:Poisson Distribution; D013269:Stochastic Processes
D002273:Carcinogens; D018736:DNA Adducts