title: Response of the extramedullary lung plasmacytoma with pleural effusion to chemotherapy.
abstract: An elderly patient with extramedullary lung plasmacytoma and subsequent pleural effusion is described. The presence of abnormal plasma cells in the pleural fluid led to diagnosis. Histologically similar conditions such as multiple myeloma and solitary myeloma of bone were ruled out by clinical evaluation. These neoplasms usually occur in the head and neck area and are not characterized by paraprotein accumulation. Few cases in the lung have been reported. We describe a case of extramedullary plasmacytoma of the lung with plasmacytoma-induced pleural effusion and the presence of monoclonal paraprotein in both the serum and urine. Chemotherapy with melphalan was effective in reducing the size of the plasmacytoma, and pleurodesis was used to manage the pleural effusion.
authors.affiliation: Department of Geriatric Medicine, Faculty of Medicine, Kyoto University, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Nagai
authors.forename: K
authors.initials: K
authors.lastname: Ando
authors.forename: H
authors.initials: H
authors.lastname: Yoshida
authors.forename: S
authors.initials: S
authors.lastname: Kusaka
authors.forename: Y
authors.initials: Y
authors.lastname: Hinuma
authors.forename: Y
authors.initials: Y
authors.lastname: Hakamata
authors.forename: K
authors.initials: K
authors.lastname: Ishii
authors.forename: N
authors.initials: N
authors.lastname: Kume
authors.forename: H
authors.initials: H
authors.lastname: Ochi
authors.forename: Y
authors.initials: Y
authors.lastname: Wakatsuki
authors.forename: M
authors.initials: M
authors.lastname: Yokode
authors.forename: M
authors.initials: M
authors.lastname: Murakami
authors.forename: T
authors.initials: T
authors.lastname: Kita
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications* / Q000188:drug therapy*; D008297:Male; D008558:Melphalan / Q000008:administration & dosage / Q000627:therapeutic use*; D010954:Plasmacytoma / Q000150:complications* / Q000188:drug therapy*; D016066:Pleural Effusion, Malignant / Q000150:complications / Q000188:drug therapy*; D018700:Pleurodesis
chemical_list: D000970:Antineoplastic Agents; D008558:Melphalan