[Insulin, vascular reactivity and hypertension].
Several epidemiological studies have shown that there is a relationship between hyperinsulinemia, insulin resistance and arterial hypertension. Insulin produces sympathetic nervous system stimulation, enhances renal sodium retention and it directly modifies vascular mechanisms involved in both contraction and relaxation of the vascular smooth muscle. These actions of insulin could lead either to elevation or reduction of blood pressure. The absence of vasodilation due to insulin resistance and/or the enhancement of the hypertensive effects due to hyperinsulinemia could be the link between insulin and hypertension.
Rebolledo
A
A
Departamento de Ciencias Biológicas, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, Argentina.
Milesi
V
V
Rinaldi
G
G
Grassi
A
A
D000818:Animals; D006801:Humans; D006946:Hyperinsulinism / Q000150:complications*; D006973:Hypertension / Q000209:etiology*; D007328:Insulin / Q000494:pharmacology; D013564:Sympathetic Nervous System / Q000187:drug effects
D007328:Insulin
Insulina, reactividad vascular e hipertensión arterial.