[The electrocardiogram of the guinea pig. Changes induced by beta-methyl digoxin acute administration].
In this study we describe the normal electrocardiogram of the Guinea pig (Cavia porcellus), including the correlation between cardiac frequency and the Q-T interval. We studied the acute changes induced by an intraperitoneal dose of beta-methyl digoxin (0.2 mg). The drug produced a significant decrease in cardiac frequency and a significant prolongation of the P-R interval. It did not change the QRS duration or its position on the frontal plane. The Q-T interval, corrected by cardiac frequency, showed a tendency to decrease with treatment, but this change did not reach significance. The drug caused characteristic changes in ventricular repolarization: the T wave changed its polarity and S-T segment shifted to negative potential (between 0.05 and 0.15 mV). The possible origin of these observation is discussed.
Padrón-Nieves
M
M
Sección de Investigaciones Cardio-Renales, Universidad Central de Venezuela, Caracas, Venezuela.
Rodríguez
M A
MA
Pérez González
M
M
Lamanna
V
V
D000818:Animals; D002316:Cardiotonic Agents / Q000494:pharmacology*; D004562:Electrocardiography / Q000187:drug effects*; D005260:Female; D006168:Guinea Pigs; D006339:Heart Rate / Q000187:drug effects*; D008297:Male; D008520:Medigoxin / Q000494:pharmacology*
D002316:Cardiotonic Agents; D008520:Medigoxin
El electrocardiograma del acure. Cambios inducidos por la admistración aguda de beta-metil digoxina.