[The vascularization of skin connective-tissue regenerates during wound healing under exposure to neurotransmitters and their antagonists].
Vascularization of skin regenerates was studied in wound healing as affected by noradrenaline (NA), acetylcholine (Ach), propranolole (PR) and atropine (AT). Regenerate vascularization was reduced under NA and AT effect, while Ach and PR promote its increase. Deviation extent of values of granulation tissue vessels specific length (SLV) (by 7th posttraumatic day) increases in proportion with the drug dose. Schematic diagrams of the studied "dose-effect" correlation approximate to S-like (logistic) curve. Relative change of SLV in regenerating dermis, that occurs as a response to wound treatment with NA, Ach, PR and AT, non-significantly expressed by third experimental day, grows sharply by day 7 and then reduces gradually. SLV reactive deviation in cholinotropic preparation use exceeds that after treatment with adrenotropic ones. Skin regenerate vessels reactions to neurotransmitters and their antagonists are not only quantitative, but qualitative as well.
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D000818:Animals; D003238:Connective Tissue / Q000098:blood supply* / Q000187:drug effects / Q000293:injuries / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D008833:Microcirculation / Q000187:drug effects / Q000502:physiology; D018377:Neurotransmitter Agents / Q000037:antagonists & inhibitors* / Q000494:pharmacology*; D051381:Rats; D012867:Skin / Q000098:blood supply* / Q000187:drug effects / Q000293:injuries; D012879:Skin Physiological Phenomena; D013997:Time Factors; D014945:Wound Healing / Q000187:drug effects* / Q000502:physiology
D018377:Neurotransmitter Agents
Vaskuliarizatsiia soedinitel'notkannykh regeneratov kozhi pri zazhivlenii ran v usloviiakh vozdeĭstviia neĭrotransmitterov i ikh antagonistov.