title: Successful thrombolysis after prosthetic pulmonary valve obstruction under aspirin monotherapy.
abstract: In a 22-year-old woman with recent onset of left-sided chest pain and exertional dyspnea, echocardiography revealed obstruction of a St. Jude Medical bileaflet prosthetic valve (size 23 mm) in the pulmonary position. Oral anticoagulation had been replaced for the previous 7 years by aspirin as the sole antithrombotic treatment. The valve had been inserted 16 years ago for pulmonary atresia. Valve function was restored by systemic application of 9 million units of urokinase.
authors.affiliation: Department of Interventional Cardiology, St. Georg Hospital Leipzig, Germany.
authors.forename: W
authors.initials: W
authors.lastname: Burger
authors.forename: G D
authors.initials: GD
authors.lastname: Kneissl
authors.forename: A
authors.initials: A
authors.lastname: Hartmann
authors.forename: R
authors.initials: R
authors.lastname: Bauersachs
authors.forename: V
authors.initials: V
authors.lastname: Döring
authors.forename: U
authors.initials: U
authors.lastname: Spengler
authors.forename: G
authors.initials: G
authors.lastname: Neumann
authors.forename: K W
authors.initials: KW
authors.lastname: Rothe
mesh_terms: D000328:Adult; D001241:Aspirin / Q000627:therapeutic use; D005260:Female; D006801:Humans; D010960:Plasminogen Activators / Q000627:therapeutic use; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use; D011475:Prosthesis Failure; D011664:Pulmonary Valve; D011665:Pulmonary Valve Insufficiency / Q000188:drug therapy / Q000209:etiology; D015912:Thrombolytic Therapy; D014568:Urokinase-Type Plasminogen Activator / Q000627:therapeutic use
chemical_list: D010975:Platelet Aggregation Inhibitors; D010960:Plasminogen Activators; D014568:Urokinase-Type Plasminogen Activator; D001241:Aspirin