title: Nifedipine and ritodrine in the management of preterm labor: a randomized multicenter trial.
abstract: OBJECTIVE
  To compare the efficacy of nifedipine with ritodrine in the management of preterm labor.
  
  
  METHODS
  One hundred eighty-five singleton pregnancies with preterm labor were assigned randomly to either ritodrine intravenously (n = 90) or nifedipine orally (n = 95). The principal outcome assessed was delay of delivery.
  
  
  RESULTS
  Ritodrine was discontinued in 12 patients because of severe maternal side effects, and their results were excluded from further analysis. More women in the ritodrine group delivered within 24 hours (22 versus 11, P = .006), within 48 hours (29 versus 21, P = .03), within 1 week (45 versus 36, P = .009), and within 2 weeks (52 versus 43, P = .005) compared with those receiving nifedipine. There were significantly fewer maternal side effects in the nifedipine group. Apgar scores and umbilical artery and vein pHs were similar in both groups. The number of admissions to the neonatal intensive care unit (NICU) in the nifedipine group was significantly lower than in the ritodrine group (68.4 versus 82.1%, P = .04).
  
  
  CONCLUSIONS
  Nifedipine in comparison with ritodrine in the management of preterm labor is significantly associated with a longer postponement of deliver, fewer maternal side effects, and fewer admissions to the NICU.
authors.affiliation: Department of Obstetrics and Gynecology, Free University Hospital, Amsterdam, The Netherlands.
authors.forename: D N
authors.initials: DN
authors.lastname: Papatsonis
authors.forename: H P
authors.initials: HP
authors.lastname: Van Geijn
authors.forename: H J
authors.initials: HJ
authors.lastname: Adèr
authors.forename: F M
authors.initials: FM
authors.lastname: Lange
authors.forename: O P
authors.initials: OP
authors.lastname: Bleker
authors.forename: G A
authors.initials: GA
authors.lastname: Dekker
mesh_terms: D000284:Administration, Oral; D000328:Adult; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000188:drug therapy / Q000453:epidemiology; D006801:Humans; D007262:Infusions, Intravenous; D009543:Nifedipine / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D007752:Obstetric Labor, Premature / Q000517:prevention & control*; D011247:Pregnancy; D011256:Pregnancy Outcome; D012312:Ritodrine / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D013997:Time Factors; D015145:Tocolysis; D015149:Tocolytic Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D015149:Tocolytic Agents; D012312:Ritodrine; D009543:Nifedipine