In vitro receptor imaging for characterization of human solid tumors.
Since many of the factors involved in tumor growth and progression act through a receptor-mediated mechanism, we applied in vitro receptor imaging techniques to study the intratumoral distribution and concentration of receptor-molecules having experimental biological relevance in such processes. Here we summarize the results of a study concerning the role of urokinase receptor (uPAR) in the acquisition of an invasive phenotype by tumor cells. Independently of the system studied, we demonstrated that in vitro receptor imaging techniques can be used to define the biological characteristics of human solid tumors and can contribute to clarify the complex network of ligand/receptor interactions leading to tumor spread.
Del Vecchio
S
S
Medicina Nucleare, Universita degli Studi Federico II, Napoli, Italy.
Stoppelli
M P
MP
Carriero
M V
MV
Fonti
R
R
Massa
O
O
Li
P Y
PY
Botti
G
G
Cerra
M
M
D'Aiuto
G
G
Esposito
G
G
D001345:Autoradiography; D001941:Breast Diseases / Q000175:diagnosis* / Q000201:enzymology / Q000378:metabolism / Q000473:pathology; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000201:enzymology / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007124:Immunoenzyme Techniques; D011956:Receptors, Cell Surface / Q000378:metabolism*; D055293:Receptors, Urokinase Plasminogen Activator; D014568:Urokinase-Type Plasminogen Activator / Q000378:metabolism
C524898:PLAUR protein, human; D011956:Receptors, Cell Surface; D055293:Receptors, Urokinase Plasminogen Activator; D014568:Urokinase-Type Plasminogen Activator