Synthetic methods for polyamine linkers and their application to combinatorial chemistry.
Polyamines and polyamine conjugates display a diverse range of important biological functions, ranging from antibiotics to immunosuppressants and glutamate receptor antagonists. For these reasons, polyamines provide an excellent template/scaffold for combinatorial chemistry. In this paper we present methods for the solid-phase immobilisation of polyamines for use in synthetic and combinatorial chemistry and describe how they have been employed in the preparation of a number of important polyamine conjugates and polyamine libraries. Thus, we have designed, synthesised and utilised a number of polyamine linkers for both solution and resin screening combinatorial application.
Marsh
I R
IR
Department of Chemistry, University of Southampton, U.K.
Smith
H K
HK
Leblanc
C
C
Bradley
M
M
D002625:Chemistry, Organic / Q000379:methods; D015195:Drug Design; D006146:Guanidines / Q000138:chemical synthesis / Q000737:chemistry; D015394:Molecular Structure; D019151:Peptide Library; D011073:Polyamines / Q000138:chemical synthesis* / Q000737:chemistry; D012117:Resins, Synthetic / Q000138:chemical synthesis / Q000737:chemistry; D013095:Spermidine / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000737:chemistry
D006146:Guanidines; D019151:Peptide Library; D011073:Polyamines; D012117:Resins, Synthetic; D013095:Spermidine; C037258:gusperimus