title: Uptake of 169Yb complexes in normal and tumour cells: influence of ligand and metabolic cell activity and stability of cellular association.
abstract: For better understanding of the accumulation of trivalent radiometal tracers in tumours, studies of uptake of different 169Yb complexes into cultured normal (V79/4) and tumour (KTCTL-2) cells were performed. Cellular uptake of 169Yb3+ is dependent on both the metabolic activity of the cells and the nature of the ligand used. Uptake of 169Yb3+ from the citrate complex is an active cellular transport process but not tumour-specific. The 169Yb-aminopolycarboxylic acid complexes are taken up via a different, unknown mechanism, and in higher amounts by the tumour cells than by the V79/4 cell line, but the general features of uptake were principally the same with the normal and the tumour cells. Uptake of the complexes studied leads to a stable association of cellular components, which is a good premise for the therapeutic use of trivalent radiometals.
authors.affiliation: Klinik und Poliklinik for Nuklearmedizin, Universitätsklinikum Carl Gustav Carus, Technische Universität Dresden, Germany.
authors.forename: G
authors.initials: G
authors.lastname: Kampf
authors.forename: G
authors.initials: G
authors.lastname: Knop
authors.forename: W G
authors.initials: WG
authors.lastname: Franke
authors.forename: R
authors.initials: R
authors.lastname: Bergmann
authors.forename: B
authors.initials: B
authors.lastname: Johannsen
mesh_terms: D000818:Animals; D002460:Cell Line; D006224:Cricetinae; D006801:Humans; D008024:Ligands; D009369:Neoplasms / Q000378:metabolism*; D011868:Radioisotopes / Q000493:pharmacokinetics*; D013696:Temperature; D015018:Ytterbium / Q000493:pharmacokinetics*
chemical_list: D008024:Ligands; D011868:Radioisotopes; D015018:Ytterbium