title: Power frequency magnetic fields do not contribute to transformation of JB6 cells.
abstract: The potential for power frequency magnetic fields to enhance neoplastic transformation has been investigated in vitro using promotion-sensitive mouse epidermal JB6 cells. In a soft agar assay, 60-Hz magnetic fields of 0.01, 0.1, 1.0, or 1.1 mT flux density did not induce anchorage-independent growth. In addition, these magnetic fields did not enhance tumor promoter-induced transformation showing no increase in the maximum number of transformed colonies and no shift in the dose-response curve. Thus, these data do not support the notion that environmental exposures to magnetic fields contribute to transformation.
authors.affiliation: Molecular Biosciences Department, Pacific Northwest National Laboratory, Richland, WA 99352, USA.
authors.forename: J D
authors.initials: JD
authors.lastname: Saffer
authors.forename: G
authors.initials: G
authors.lastname: Chen
authors.forename: N H
authors.initials: NH
authors.lastname: Colburn
authors.forename: S J
authors.initials: SJ
authors.lastname: Thurston
mesh_terms: D000818:Animals; D001790:Blood Physiological Phenomena; D002471:Cell Transformation, Neoplastic; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D008280:Magnetics; D051379:Mice; D013755:Tetradecanoylphorbol Acetate / Q000633:toxicity
chemical_list: D013755:Tetradecanoylphorbol Acetate