title: MnDPDP enhancement in rabbit liver after intravenous bolus injection and slow infusion.
abstract: OBJECTIVE
  To investigate the MR-enhancing effect of mangafodipir trisodium (MnDPDP, Teslascan) in the rabbit liver in relation to dose, mode of administration and imaging window.
  
  
  METHODS
  MnDPDP was administered to 18 rabbits at a dose of 10 mumol/kg or 20 mumol/kg, as a bolus injection or infusion. MR imaging of the liver was performed at different time intervals.
  
  
  RESULTS
  Peak liver enhancement was typically observed 10-30 min after administration and the enhancement declined with a half-time of about 5 h. This pattern was observed in all sequences (SE 400/15, FLASH, and SE 132/10), with both doses and with both rates of administration. The peak enhancement was greater, though not significantly so after 20 mumol/kg than after 10 mumol/kg. A higher relative peak signal was observed with SE 132/10 than with FLASH or SE 400/15.
  
  
  CONCLUSIONS
  A good liver imaging result was obtained after a dose of 10 mumol/kg, either bolus or infusion, 10-30 min post-contrast with heavily T1-weighted sequences.
authors.affiliation: Department of Diagnostic Radiology, University Hospital, Karolinska Institute, Huddinge, Sweden. ornthors@rhi.hi.is
authors.forename: O
authors.initials: O
authors.lastname: Thorstensen
authors.forename: B
authors.initials: B
authors.lastname: Isberg
authors.forename: H
authors.initials: H
authors.lastname: Jorulf
authors.forename: L
authors.initials: L
authors.lastname: Westman
authors.forename: U
authors.initials: U
authors.lastname: Svahn
authors.forename: N
authors.initials: N
authors.lastname: Venizelos
mesh_terms: D000818:Animals; D003287:Contrast Media / Q000008:administration & dosage; D004305:Dose-Response Relationship, Drug; D004492:Edetic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives*; D005260:Female; D007262:Infusions, Intravenous; D007275:Injections, Intravenous; D008099:Liver / Q000033:anatomy & histology*; D008279:Magnetic Resonance Imaging / Q000379:methods / Q000706:statistics & numerical data; D008297:Male; D008345:Manganese / Q000008:administration & dosage; D011732:Pyridoxal Phosphate / Q000008:administration & dosage / Q000031:analogs & derivatives*; D011817:Rabbits; D011897:Random Allocation; D013997:Time Factors
chemical_list: D003287:Contrast Media; D008345:Manganese; D011732:Pyridoxal Phosphate; D004492:Edetic Acid; C060076:N,N'-bis(pyridoxal-5-phosphate)ethylenediamine-N,N'-diacetic acid