The importance of plasma polymorphonuclear (PMN) elastase determination in patients with uveitis.
OBJECTIVE
Polymorphonuclear elastase is used as an important marker for inflammatory disease. We wanted to show whether polymorphonuclear elastase could be a marker in uveitis.


METHODS
Twenty-two patients with uveitis and 30 healthy control subjects were included in the study. Polymorphonuclear elastase levels were determined by immunoactivation method before and after periods of corticosteroid and/or cyclosporin treatments.


RESULTS
The levels were high in all of the patients before treatment; the levels reached normal range with treatment. In some cases, however, uveitis could not be suppressed in spite of treatment; these patients had high polymorphonuclear elastase levels.


CONCLUSIONS
It was concluded that determination of polymorphonuclear elastase level may be used for monitoring of uveitis.
Akyol
N
N
Department of Ophthalmology, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey.
Değer
O
O
Erdöl
H
H
Gedik
Y
Y
Orem
A
A
Imamoglu
H I
HI
D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood; D016572:Cyclosporine / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007958:Leukocyte Count; D019272:Leukocyte Elastase / Q000097:blood*; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome; D014605:Uveitis / Q000097:blood* / Q000188:drug therapy
D015415:Biomarkers; D005938:Glucocorticoids; D007166:Immunosuppressive Agents; D016572:Cyclosporine; D019272:Leukocyte Elastase