Commonly prescribed salt intake in continuous ambulatory peritoneal dialysis patients is too restrictive: results of a double-blind crossover study.
Salt restriction in continuous ambulatory peritoneal dialysis (CAPD) patients is widely prescribed and thereby may reduce quality of life. It is presumed that this has a beneficial effect on BP and reduces the need for hypertonic dialysate. However, this has never been formally evaluated. A double-blind crossover study of placebo versus sodium chloride pills (60 mEq of sodium per day) is presented in 20 stable CAPD patients, 10 of whom were hypertensive. Dietary sodium was quantified throughout the study by 3-d dietary histories and remained unaltered throughout. There was a clinically unimportant but statistically significant rise in BP with added salt: 135/77 to 144/82 (P < 0.05). No rise in BP occurred in the hypertensive patients. Weights, use of hypertonic dialysate, and BP medications remained unaltered throughout the study. In conclusion, 200 mEq of sodium per day, i.e., a normal sodium intake, is easily tolerated in stable CAPD patients, and the recommended sodium intake commonly prescribed is too restrictive.
Fine
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A
Section of Nephrology, St. Boniface General Hospital, Winnipeg, Manitoba, Canada.
Fontaine
B
B
Ma
M
M
D000368:Aged; D001794:Blood Pressure; D001835:Body Weight; D018592:Cross-Over Studies; D004039:Diet, Sodium-Restricted / Q000523:psychology; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D008297:Male; D008875:Middle Aged; D010349:Patient Compliance; D010531:Peritoneal Dialysis, Continuous Ambulatory / Q000523:psychology; D011788:Quality of Life; D012982:Sodium, Dietary / Q000008:administration & dosage*
D012982:Sodium, Dietary