Structure-function relationships of the PEA3 group of Ets-related transcription factors.
The PEA3 group of transcription factors belongs to the Ets family and is composed of PEA3, ERM, and ER81, which are more than 95% identical within the DNA-binding domain--the ETS domain--and which demonstrate 50% aa identity overall. We present here a review of the current knowledge of these transcription factors, which possess functional domains responsible for DNA-binding, DNA-binding inhibition, and transactivation. Recent data suggest that these factors are targets for signaling cascades, such as the Ras-dependent ones, and thus may contribute first to the nuclear response to cell stimulation and second to Ras-induced cell transformation. The expression of the PEA3 group members in numerous developing murine organs, and, especially, in epithelial-mesenchymal interaction events, suggests a key role in murine organogenesis. Moreover, their expression in certain breast cancer cells suggests a possible involvement of these genes in the appearance, progression, and invasion of malignant cells.
de Launoit
Y
Y
UMR 319 CNRS, Institut Pasteur de Lille, France. delaunoi@infobiogen.fr
Baert
J L
JL
Chotteau
A
A
Monte
D
D
Defossez
P A
PA
Coutte
L
L
Pelczar
H
H
Leenders
F
F
D000595:Amino Acid Sequence; D004268:DNA-Binding Proteins / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D005810:Multigene Family; D015513:Oncogene Proteins; D017434:Protein Structure, Tertiary; D050783:Proto-Oncogene Proteins c-ets; D012512:Sarcoma, Ewing / Q000235:genetics; D017386:Sequence Homology, Amino Acid; D013329:Structure-Activity Relationship; D014157:Transcription Factors / Q000235:genetics*
D004268:DNA-Binding Proteins; C086924:Elk3 protein, mouse; D015513:Oncogene Proteins; D050783:Proto-Oncogene Proteins c-ets; D014157:Transcription Factors