Synaptic signaling by nitric oxide.
Endogenous nitric oxide (NO) mediates certain aspects of synaptic plasticity and neurotoxicity associated with NMDA-type glutamate receptors. Neuronal NO synthase contains a modular protein-protein interaction motif, termed the PDZ domain, that links the synthase to a synaptic protein complex containing postsynaptic density protein PSD-95 and NMDA receptors. Characterization of this pathway has provided new insights into the role of NO in brain physiology and disease.
Brenman
J E
JE
Department of Physiology and Program in Biomedical Sciences, University of California at San Francisco, 513 Parnassus Avenue, San Francisco, California 94143-0444, USA.
Bredt
D S
DS
D000818:Animals; D006624:Hippocampus / Q000187:drug effects; D008954:Models, Biological; D018482:Muscle, Skeletal / Q000187:drug effects; D009569:Nitric Oxide / Q000494:pharmacology*; D015398:Signal Transduction / Q000502:physiology*; D009435:Synaptic Transmission / Q000187:drug effects*
D009569:Nitric Oxide