Effectiveness of aldose reductase inhibitors for diabetic gastroenteropathy with constipation.
We present a diabetic patient with long-standing constipation complicated by paralytic ileus and septic shock. She successfully recovered from a critical condition, and her diabetes was well controlled. However, the constipation did not improve even after the administration of conventional medications. Epalrestat, an aldose reductase inhibitor (ARI), improved her bowel motility and autonomic cardiovascular dysfunction, as evident from her heart rate and blood pressure response. Gastroenteropathy is a major diabetic complication which may cause disturbed bowel motility leading to serious enterobacterial infections, thus, its amelioration is important. ARI may be beneficial in the treatment of diabetic gastroenteropathy refractory to conventional therapies.
Nakamura
T
T
Department of Internal Medicine, Kumihama Municipal Hospital, Kumano-gun, Kyoto.
Okano
R
R
Uchiyama
H
H
Seo
Y
Y
Okuda
S
S
D000449:Aldehyde Reductase / Q000037:antagonists & inhibitors* / Q000502:physiology; D001342:Autonomic Nervous System Diseases / Q000188:drug therapy* / Q000209:etiology; D002318:Cardiovascular Diseases / Q000188:drug therapy / Q000209:etiology; D003248:Constipation / Q000188:drug therapy* / Q000209:etiology; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D003929:Diabetic Neuropathies / Q000150:complications*; D004791:Enzyme Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects*; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007418:Intestinal Pseudo-Obstruction / Q000209:etiology; D008875:Middle Aged; D012236:Rhodanine / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D012772:Shock, Septic / Q000209:etiology; D053778:Thiazolidines
D004791:Enzyme Inhibitors; D053778:Thiazolidines; C038131:epalrestat; D012236:Rhodanine; D000449:Aldehyde Reductase