Adenolymphoma and non-Hodgkin's lymphoma of the salivary glands and oral cavity in immunocompetent patients are not associated with latent Epstein-Barr virus.
The presence of Epstein-Barr virus (EBV) was studied in specimens of 50 primary non-Hodgkin's lymphomas (NHL) of the salivary gland and the oral cavity and 11 solitary adenolymphomas of the parotid gland, using EBER-1/2 in situ hybridisation and by immunohistochemistry for the detection of latent membrane-protein-1 (LMP-1). None of the patients were tested for HIV-infection, nor were there any clinical signs to suspect HIV-infection. In one adenolymphoma, few reactive EBER-1/2 positive cells were detected. In this case staining for LMP-1 was negative. In one oral B-cell NHL, EBER-1/2 positive lymphoma cells were identified; these cells also expressed LMP-1. None of the 31 oral (30 B-cell and one T-cell) and 18 salivary gland (all B-cell) NHLs and none of the 10 adenolymphomas were EBER-1/2 positive or expressed LMP-1. These results indicate that EBV is not involved in the pathogenesis of oral and salivary gland primary NHL and adenolymphoma in immunocompetent patients.
Wolvius
E B
EB
Department of Oral & Maxillofacial Surgery and Oral Pathology, Free, University Hospital, Amsterdam, The Netherlands.
Jiwa
N M
NM
van der Valk
P
P
Horstman
A
A
van der Waal
I
I
D000235:Adenolymphoma / Q000473:pathology / Q000821:virology*; D004854:Herpesvirus 4, Human / Q000302:isolation & purification* / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D016130:Immunophenotyping; D017403:In Situ Hybridization; D008228:Lymphoma, Non-Hodgkin / Q000821:virology*; D009062:Mouth Neoplasms / Q000821:virology*; D010307:Parotid Neoplasms / Q000473:pathology / Q000821:virology; D012468:Salivary Gland Neoplasms / Q000821:virology*; D014764:Viral Proteins / Q000378:metabolism
D014764:Viral Proteins