[Chronic interstitial pneumonia and crescentic glomerulonephritis associated with perinuclear antineutrophil cytoplasmic antibodies].
We examined a 72-year-old man suffering from chronic interstitial pneumonia with crescentic glomerulonephritis associated with perinuclear antineutrophil cytoplasmic antibodies (P-ANCA). Ten years before admission, he was given a diagnosis of interstitial pneumonia, but received no medication. He was admitted to our hospital because of a high fever and back pain. Antibiotics were used, but without success. The serum P-ANCA titer was high, and examination of a kidney biopsy specimen showed crescentic glomerulonephritis. Computed tomography of the chest showed that the lungs had a honecomblike appearance, and examination of a specimen obtained by transbronchial lung biopsy showed interstitial fibrosis. This case shows that interstitial pneumonia can be associated with P-ANCA. It is important to be a wore that crescentic glomerulonephritis associated with P-ANCA can develop in patients with interstitial pneumonia.
Matsuyama
W
W
Department of Chest Medicine, Minami-Kyushu National Hospital, Kagoshima, Japan.
Koreeda
Y
Y
Mizuno
K
K
Mizoguchi
A
A
Iwami
F
F
Osame
M
M
D000368:Aged; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000032:analysis*; D005921:Glomerulonephritis / Q000150:complications* / Q000276:immunology; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000150:complications* / Q000276:immunology; D008297:Male
D019268:Antibodies, Antineutrophil Cytoplasmic