Severe hepatotoxicity on beginning propylthiouracil therapy.
We report a case of propylthiouracil (PTU)-induced cholestatic hepatotoxicity in Graves' disease that developed 1 day after beginning PTU. After clinical recover, liver abnormalities persisted for 5 years. Percutaneous liver biopsy and the eventual normalization of enzyme levels excluded permanent liver damage as a result of PTU therapy. Thus prolonged elevation of serum enzymes is consistent with the diagnosis of PTU-induced hepatotoxicity, which may recover completely.
Lock
D R
DR
Endocrinology Unit, Kaplan Hospital, Rehovot, Israel.
Sthoeger
Z M
ZM
D013956:Antithyroid Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001706:Biopsy; D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis / Q000209:etiology*; D004796:Clinical Enzyme Tests; D005260:Female; D006111:Graves Disease / Q000188:drug therapy; D006801:Humans; D008099:Liver / Q000473:pathology; D008111:Liver Function Tests; D008875:Middle Aged; D011441:Propylthiouracil / Q000009:adverse effects* / Q000627:therapeutic use; D013997:Time Factors
D013956:Antithyroid Agents; D011441:Propylthiouracil