Effects of auro-detoxin treatment on vascular responses in mouse aorta.
1. In this study, we investigated the effects of chronic Auro-detoxin treatment for 5 and 10 weeks on reactivity to vascular agonists in the mouse aorta. 2. The maximum contractile responses to and the -log EC50 values of phenylephrine (Phe) were not changed with Auro-detoxin treatment. 3. The maximum contractile responses to 5-hydroxytryptamine (5-HT) were not changed over 5 weeks but were significantly increased with Auro-detoxin treatment during a 10-week period. The -log EC50 values of 5-HT were found to be significantly decreased in both treatment groups. 4. The maximum relaxation responses to acetylcholine (ACh) were decreased in both treatment groups. The -log EC50 values of ACh were not changed in 5 weeks but significantly decreased in 10 week-treated animals. 5. Neither the maximum relaxation responses not the -log EC50 values of sodium nitroprusside (SNP) were changed with Auro-detoxin treatment. 6. These results suggest that chronic gold treatment affects vascular responses in the mouse aorta.
Güney
H Z
HZ
Department of Pharmacology, Faculty of Medicine, Gazi University, Ankara, Turkey.
Görgün
C Z
CZ
Hodoğlugil
U
U
Zengil
H
H
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D001011:Aorta / Q000187:drug effects* / Q000502:physiology; D004730:Endothelium, Vascular / Q000187:drug effects / Q000502:physiology; D005260:Female; D066298:In Vitro Techniques; D051379:Mice; D008807:Mice, Inbred BALB C; D009126:Muscle Relaxation / Q000187:drug effects; D009599:Nitroprusside / Q000494:pharmacology; D010455:Peptides / Q000008:administration & dosage / Q000494:pharmacology*; D014662:Vasoconstrictor Agents / Q000008:administration & dosage / Q000494:pharmacology*
D010455:Peptides; D014662:Vasoconstrictor Agents; D009599:Nitroprusside; C001580:gold keratinate; D000109:Acetylcholine