title: Anesthetic potency of desflurane in the horse: determination of the minimum alveolar concentration.
abstract: OBJECTIVE
  To determine the minimum alveolar concentration (MAC) of desflurane (DES) in the horse.
  
  
  METHODS
  Prospective study.
  
  
  METHODS
  Six healthy adult horses (three males and three females) weighing 370 +/- 16 kg and aged 9 +/- 2 years old.
  
  
  METHODS
  Anesthesia was induced with DES vaporized in oxygen via a face mask connected to a large-animal, semiclosed anesthetic circle system. The horses were endotracheally intubated and positioned in right lateral recumbency. Inspired and end-tidal DES were monitored using a calibrated Ohmeda RGM 5250 multigas analyzer (Ohmeda-BOC, Spain). The MAC of desflurane that prevented gross purposeful movement in response to 60 seconds of noxious electrical stimulation of oral mucous membranes was determined.
  
  
  RESULTS
  The time from the start of DES administration to lateral recumbency was 6.1 +/- 0.9 min. The MAC of DES in these horses was 7.6 +/- 0.4%. Time required for the animal to regain sternal recumbency after 98 +/- 4 minutes of anesthesia was 6.6 +/- 0.5 minutes and the time to standing was 14.3 +/- 2.7 minutes.
  
  
  CONCLUSIONS
  The MAC of desflurane in these horses was 7.6 +/- 0.4%. DES provided a rapid induction to, and recovery from, anesthesia.
  
  
  CONCLUSIONS
  Desflurane offers the potential for more precise control during anesthesia, and may allow a faster and uneventful recovery. It is important to know the MAC of an inhalant to use it clinically.
authors.affiliation: Facultad de Veterinaria, Departamento de Patología Animal II, Universidad Complutense de Madrid, Spain.
authors.forename: F J
authors.initials: FJ
authors.lastname: Tendillo
authors.forename: A
authors.initials: A
authors.lastname: Mascías
authors.forename: M
authors.initials: M
authors.lastname: Santos
authors.forename: J
authors.initials: J
authors.lastname: López-Sanromán
authors.forename: R
authors.initials: R
authors.lastname: De Rossi
authors.forename: F
authors.initials: F
authors.lastname: San Román
authors.forename: I A
authors.initials: IA
authors.lastname: Gómez de Segura
mesh_terms: D000280:Administration, Inhalation; D018685:Anesthetics, Inhalation / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology*; D000818:Animals; D000077335:Desflurane; D005260:Female; D006736:Horses / Q000378:metabolism; D007530:Isoflurane / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000494:pharmacology; D008297:Male; D011446:Prospective Studies; D011650:Pulmonary Alveoli / Q000378:metabolism
chemical_list: D018685:Anesthetics, Inhalation; D000077335:Desflurane; D007530:Isoflurane