Treatment of murine disseminated candidiasis with L-743,872.
L-743,872 (M991), which is a pneumocandin derivative, was evaluated in a mouse model of disseminated candidiasis caused by a fluconazole-resistant isolate of Candida albicans. In immunocompetent mice M991 prolonged survival at doses as low as 0.0125 mg/kg of body weight per day. In neutropenic mice 0.05 mg/kg was the lowest effective dose. M991 is a very potent drug for treatment of disseminated candidiasis.
Graybill
J R
JR
University of Texas Health Science Center at San Antonio and Audie Murphy Memorial Veterans Hospital, 78284, USA. GRAYBILL@UTHSCSA.EDU
Najvar
L K
LK
Luther
M F
MF
Fothergill
A W
AW
D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D000935:Antifungal Agents / Q000627:therapeutic use*; D002176:Candida albicans / Q000187:drug effects; D002177:Candidiasis / Q000188:drug therapy*; D000077336:Caspofungin; D054714:Echinocandins; D055666:Lipopeptides; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010455:Peptides; D010456:Peptides, Cyclic
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D010455:Peptides; D010456:Peptides, Cyclic; D000077336:Caspofungin