Changes in cigarette smoking not observed following repeated cocaine self-administration.
Acute administration of some psychoactive drugs (e.g., cocaine, heroin, methadone d-amphetamine) has been found to increase spontaneous cigarette smoking for 1-3 hr, but the effects of chronic drug administration have not been systematically studied. Computerized cigarette dispensers were used to study the effects of multiple daily cocaine administrations on cigarette smoking. Participants were 8 (5 male) cocaine-dependent cigarette smokers who resided on a closed clinical research ward and smoked an average of 16.7 cigarettes per day during the week prior to starting the study. During test sessions on Monday, Wednesday, and Friday of each week, participants could obtain either cocaine (25 mg i.v.) on 2 days or saline (1 ml i.v.) on the other day, 3 times per day at 2-hr intervals under double-blind conditions. The number of cigarettes dispensed during study days was analyzed in 2-hr increments. No significant cocaine effect was found. These findings fail to show a change in the number of cigarettes smoked after chronic cocaine self-administration over time intervals longer than 1-3 hr.
Radzius
A
A
Clinical Pharmacology Branch, National Institute on Drug Abuse, Baltimore, Maryland 21224, USA.
Carriero
N J
NJ
Weinhold
L L
LL
Gorelick
D A
DA
Henningfield
J E
JE
D000328:Adult; D003042:Cocaine / Q000494:pharmacology*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D009294:Narcotics / Q000494:pharmacology*; D012907:Smoking / Q000523:psychology*; D019966:Substance-Related Disorders / Q000523:psychology
D009294:Narcotics; D003042:Cocaine