title: The utilization of a biological adhesive for wound treatment: comparison of suture, self-sealing sutureless and cyanoacrylate closure in the tensile strength test.
abstract: We produced a measurement apparatus for testing the tensile strength of wounds during cataract surgery, and tested the tensile strength of treated wounds including wounds sutured with various methods, non-sutured and wounds treated with various bio-tissue adhesives.
  
  
  METHODS
  In cataract surgery on white rabbits eyes, a corneoscleral incision 5 mm in length was made 2.5 mm from the limbus corneae, and entry into the anterior chamber was obtained 0.5 mm to the clear cornea. After treatment for closure, the corneoscleral piece was subjected to the tensile strength test.
  
  
  RESULTS
  The tensile strengths just after surgery were (1) 0 gf/mm2 after self-sealing sutureless closure; (2) 114 gf/mm2 after vertical suture closure (one stitch with 10-0 nylon); (3) 125 gf/mm2 after horizontal suture closure (one stitch with 10-0 nylon); (4) 143 gf/mm2 after infinity suture closure (with 10-0 nylon); (5) 112 gf/mm2 after fibrin glue (Beriplast P) application (instilled on the surface of scleral incision); (6) 121 gf/mm2 after fibrin glue application (glued on corneoscleral wound); (7) 131 gf/mm2 after cyanoacrylate closure (instilled on the surface of scleral incision); (8) 139 gf/mm2 after cyanoacrylate closure (glued on corneoscleral wound). The respective strengths at four days after surgery were: (1) 86; (2) 131; (3) 137; (4) 175; (5) 109; (6) 43; (7) 138; and (8) 108 gf/mm2. At 28 days after surgery, the respective strengths were (1) 164; (2) 167; (3) 184; (4) 209; (5) 322; (6) 195; (7) 251; and (8) 175 gf/mm2.
  
  
  CONCLUSIONS
  The use of fibrin glue in treatment of a wound in cataract surgery is beneficial in assisting this treatment.
authors.affiliation: Department of Ophthalmology, Fujita Health University School of Medicine, Fujita Health University, Aichi-Pref., Japan.
authors.forename: T
authors.initials: T
authors.lastname: Shigemitsu
authors.forename: Y
authors.initials: Y
authors.lastname: Majima
mesh_terms: D000818:Animals; D002387:Cataract Extraction / Q000379:methods; D003315:Cornea / Q000601:surgery*; D003487:Cyanoacrylates; D015718:Fibrin Tissue Adhesive; D008297:Male; D011817:Rabbits; D012590:Sclera / Q000601:surgery*; D013536:Suture Techniques; D013718:Tensile Strength; D014945:Wound Healing / Q000502:physiology
chemical_list: D003487:Cyanoacrylates; D015718:Fibrin Tissue Adhesive