Pharmacodynamics of antimicrobial agents and rationale for their dosing.
Antimicrobial pharmacodynamics are an area of considerable importance in terms of dose regimen optimisation and clinical outcome. The pharmacodynamic properties of penicillins, cephalosporins, carbapenems, quinolones, glycopeptides and aminoglycosides are reviewed; the impact such knowledge may have in the future on how we dose these agents is discussed.
MacGowan
A P
AP
Bristol Centre for Antimicrobial Research and Evaluation, Southmead Health Services NHS Trust, UK.
Bowker
K E
KE
D042462:4-Quinolones; D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000494:pharmacology*; D000890:Anti-Infective Agents / Q000008:administration & dosage* / Q000494:pharmacology*; D015780:Carbapenems / Q000008:administration & dosage / Q000494:pharmacology; D002511:Cephalosporins / Q000008:administration & dosage / Q000494:pharmacology; D004334:Drug Administration Schedule; D006020:Glycopeptides; D006801:Humans; D008826:Microbial Sensitivity Tests; D010406:Penicillins / Q000008:administration & dosage / Q000494:pharmacology
D042462:4-Quinolones; D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D015780:Carbapenems; D002511:Cephalosporins; D006020:Glycopeptides; D010406:Penicillins