title: Physicochemical characterisation of mangafodipir trisodium.
abstract: OBJECTIVE
  To determine the structure and various physicochemical properties of mangafodipir (MnDPDP) trisodium, the active ingredient of Teslascan, a new-organ-specific contrast medium for MR imaging.
  
  
  METHODS
  The structure of MnDPDP trisodium crystals was determined by X-ray crystallography. The possible existence of polymorphism in MnDPDP trisodium was evaluated by powder X-ray diffraction, optical microscopy, thermal analysis and IR spectroscopy. In addition, various spectroscopic techniques and physicochemical measurements were used for characterisation of MnDPDP trisodium.
  
  
  RESULTS
  The crystallographic data obtained for MnDPDP trisodium show that the general core structure of the MnDPDP anion is similar to that seen in related substances. The metal coordination geometry is a distorted octahedron defined by 2 phenolate oxygens, 2 carboxylate oxygens and 2 amine nitrogens. The unit cell contains 2 MnDPDP anions, 6 sodium ions and 50 water molecules. The various spectroscopic data are consistent with the structure determined by X-ray crystallography. The product (Teslascan) has low viscosity, is isotonic with blood and has a physiological pH.
  
  
  CONCLUSIONS
  MnDPDP trisodium is a crystalline, hygroscopic solid which is readily soluble in water. No evidence of polymorphism was seen in the samples studied.
authors.affiliation: Nycomed Imaging AS, Oslo, Norway. bct@nycomed.com
authors.forename: B
authors.initials: B
authors.lastname: Tirkkonen
authors.forename: A
authors.initials: A
authors.lastname: Aukrust
authors.forename: E
authors.initials: E
authors.lastname: Couture
authors.forename: D
authors.initials: D
authors.lastname: Grace
authors.forename: Y
authors.initials: Y
authors.lastname: Haile
authors.forename: K M
authors.initials: KM
authors.lastname: Holm
authors.forename: H
authors.initials: H
authors.lastname: Hope
authors.forename: A
authors.initials: A
authors.lastname: Larsen
authors.forename: H S
authors.initials: HS
authors.lastname: Lunde
authors.forename: C E
authors.initials: CE
authors.lastname: Sjøgren
mesh_terms: D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003287:Contrast Media / Q000032:analysis / Q000737:chemistry*; D003460:Crystallization; D018360:Crystallography, X-Ray; D004492:Edetic Acid / Q000031:analogs & derivatives* / Q000032:analysis / Q000737:chemistry; D008345:Manganese / Q000032:analysis / Q000737:chemistry*; D015394:Molecular Structure; D011732:Pyridoxal Phosphate / Q000031:analogs & derivatives* / Q000032:analysis / Q000737:chemistry; D012996:Solutions; D013057:Spectrum Analysis
chemical_list: D003287:Contrast Media; D012996:Solutions; D008345:Manganese; D011732:Pyridoxal Phosphate; D004492:Edetic Acid; C060076:N,N'-bis(pyridoxal-5-phosphate)ethylenediamine-N,N'-diacetic acid