title: Long-term results of hydroxyapatite-fibrin glue implantation in plastic and reconstructive craniofacial surgery.
abstract: The bone tissue formed in orthotopic or heterotopic implants of granular, porous hydroxyapatite and fibrin glue was examined several (2 1/2-8) years after implantation. The results showed distinct ossification in all cases and the functional situation and external appearance were also satisfactory. The reconstituted spongy and compact bone underwent a remodelling process similar to that of normal bone. Most of the hydroxyapatite granules were embedded in the bone tissue; a few were very close to the fibrillar connective tissue of the intertrabecular spaces and were either covered by osteoid-like collagenous borders or were in contact with osteoclast-like giant cells. Even if the results refer only to a few patients, and were obtained from a cross-sectional study, they allow the conclusion to be reached that the implantation of porous hydroxyapatite and fibrin glue leads to the formation of long-lasting bone whose hardness is equal to, or greater than, that of normal bone.
authors.affiliation: Division of Maxillofacial Surgery, San Giovanni-Addolorata Hospital, Rome, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Fortunato
authors.forename: E
authors.initials: E
authors.lastname: Marini
authors.forename: F
authors.initials: F
authors.lastname: Valdinucci
authors.forename: E
authors.initials: E
authors.lastname: Bonucci
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001672:Biocompatible Materials / Q000494:pharmacology*; D001861:Bone Regeneration / Q000187:drug effects*; D003430:Cross-Sectional Studies; D017886:Durapatite / Q000494:pharmacology*; D005147:Facial Bones / Q000601:surgery*; D005260:Female; D015718:Fibrin Tissue Adhesive / Q000494:pharmacology*; D005500:Follow-Up Studies; D006258:Head and Neck Neoplasms / Q000534:rehabilitation; D006801:Humans; D008297:Male; D008875:Middle Aged; D019736:Prostheses and Implants; D013518:Surgery, Plastic / Q000379:methods*; D016896:Treatment Outcome
chemical_list: D001672:Biocompatible Materials; D015718:Fibrin Tissue Adhesive; D017886:Durapatite