title: Development of FIV-specific cytolytic T-lymphocyte responses in cats upon immunisation with FIV vaccines.
abstract: Vaccine protection has been achieved in cats against experimental infection with feline immunodeficiency virus (FIV). Such protection has been attributed to FIV-specific humoral immunity, as well as cellular immunity of unknown mechanism(s). Since cell-mediated immunity plays a crucial role in the clearance of viral infections, this study evaluated the role of FIV-specific CTL in vaccine prophylaxis. Cats were immunised with inactivated FIV vaccines, reported to have > 90% vaccine efficacy. Significant levels of specific CTL activity were detected following the third immunisation. CTL activity persisted for several months and could be enhanced through a booster immunisation. The levels of CTL activity were comparable to those induced by a recombinant canarypoxvirus based FIV vaccine. These results suggest a possible role for CTL-mediated immunity in vaccine protection against FIV infection in cats.
authors.affiliation: Department of Pathobiology, School of Veterinary Medicine, University of Florida, Gainesville 32611, USA.
authors.forename: M C
authors.initials: MC
authors.lastname: Tellier
authors.forename: J
authors.initials: J
authors.lastname: Soos
authors.forename: R
authors.initials: R
authors.lastname: Pu
authors.forename: D
authors.initials: D
authors.lastname: Pollock
authors.forename: J K
authors.initials: JK
authors.lastname: Yamamoto
mesh_terms: D000818:Animals; D000956:Antigens, Viral; D016516:CD4-CD8 Ratio; D002415:Cats / Q000276:immunology*; D003602:Cytotoxicity, Immunologic; D016181:Feline Acquired Immunodeficiency Syndrome / Q000517:prevention & control*; D007111:Immunity, Cellular; D007114:Immunization; D016089:Immunodeficiency Virus, Feline / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*; D014765:Viral Vaccines
chemical_list: D000956:Antigens, Viral; D014765:Viral Vaccines