title: [A conjugate of ristomycin A ristosaminylaglycon-polymyxin B: the spectrum of its antimicrobial action and its membranolytic activity].
abstract: Antimicrobial activity of a conjugate based on two antibiotics, i.e. ristomycin A and polymyxin B was studied. The conjugate was shown to have a broad antimicrobial spectrum. In concentrations of 5 to 30 micrograms/ml it inhibited the growth of gram-positive and gram-negative bacteria and in concentrations of 5 to 40 micrograms/ml it inhibited the growth of the pathogenic clinical strains. An insignificant membranolytic action of the conjugate with respect to membranes of the susceptible bacteria and no hemolytic action on human red blood cells were detected.
authors.forename: A N
authors.initials: AN
authors.lastname: Polin
authors.forename: Z M
authors.initials: ZM
authors.lastname: Petrykina
authors.forename: G S
authors.initials: GS
authors.lastname: Katrukha
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination / Q000494:pharmacology*; D006461:Hemolysis / Q000187:drug effects*; D006801:Humans; D008826:Microbial Sensitivity Tests; D011112:Polymyxin B / Q000494:pharmacology*; D011523:Protoplasts / Q000187:drug effects; D012310:Ristocetin / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D012310:Ristocetin; C016719:ristocetin A; D011112:Polymyxin B
vernacular_title: Kon''iugat ristozaminilaglikon ristomitsina A--polimiksin B: spektr antimikrobnogo deĭstviia i membranoliticheskaia aktivnost'.