title: Improving the cytogenetic response to interferon alpha by zidovudine (AZT) in an HIV-positive chronic myelogenous leukemia patient.
abstract: An asymptomatic HIV-positive patient with Philadelphia chromosome positive chronic myelogenous leukemia (CML) was treated by interferon-a (IFN-a) for four years. A sustained hematological response and major cytogenetic response were achieved. However, a complete cytogenetic remission (100% Ph-negative cells) was observed when zidovudine (AZT) was introduced as treatment for HIV-related immunodepression. Moreover, this complete cytogenetic remission was confirmed by quantitative PCR showing decreased BCR-ABL rearrangement at very low level. As, there are some in vitro reports demonstrating a synergistic antiproliferative effect of IFN-a and zidovudine, we discuss the possibility of synergistic effects between AZT and IFNa in the treatment of CML.
authors.affiliation: Laboratoire Greffe de Moelle Université, (UMR CNRS 5540 Université Bordeaux 2), France.
authors.forename: F X
authors.initials: FX
authors.lastname: Mahon
authors.forename: C B
authors.initials: CB
authors.lastname: Nabera
authors.forename: J L
authors.initials: JL
authors.lastname: Pellegrin
authors.forename: P
authors.initials: P
authors.lastname: Cony-Makhoul
authors.forename: B
authors.initials: B
authors.lastname: Leng
authors.forename: P
authors.initials: P
authors.lastname: Bernard
authors.forename: J
authors.initials: J
authors.lastname: Reiffers
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D006679:HIV Seropositivity / Q000188:drug therapy*; D006403:Hematologic Tests; D006801:Humans; D007370:Interferon Type I / Q000627:therapeutic use*; D007621:Karyotyping; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000188:drug therapy* / Q000276:immunology; D008297:Male; D011994:Recombinant Proteins; D015215:Zidovudine / Q000627:therapeutic use*
chemical_list: D019380:Anti-HIV Agents; D000970:Antineoplastic Agents; D007370:Interferon Type I; D011994:Recombinant Proteins; D015215:Zidovudine