Wound Healing: An endpoint for complex peripheral angioplasty.
OBJECTIVE
The standard endpoint for lower limb revascularization is long-term patency; however, in high-risk patients with end-stage ischemia, healing of chronic ulcerations has been proposed as an acceptable endpoint. To evaluate if today's minimally invasive interventions, in combination with comprehensive wound healing procedures, can resolve nonhealing wounds, we performed a retrospective review of chronic ulceration patients treated at the San Francisco Wound Care Center.


METHODS
Eight-five patients with 96 limbs at risk due to nonhealing ulcers were treated with a variety of endovascular procedures: 7 patients (group I) received Palmaz stents for unilateral iliac occlusions; 42 limbs (group II) in 39 patients were treated with balloon angioplasty for superficial femoral and popliteal lesions; and 47 extremities in 39 patients (group III) underwent rotational atherectomy for tibioperoneal lesions. Comprehensive wound management techniques, including the application of growth factors, were used.


RESULTS
All group I wounds healed, although 6 of 7 patients required additional procedures to address outflow lesions. In groups II and III, primary patencies were similar (64% and 70%, respectively), and nine treated sites reoccluded in each group. Restenotic lesions were retreated in both groups (three in group II and four in group III) secondary patencies were 71% and 78%, respectively. There were more amputations in group III patients (five) compared to group II (one). In both groups after 5 months, 90% of wounds had healed in group II and 72% in group III.


CONCLUSIONS
The use of endovascular procedures appears to play an important role in the healing of chronic lower extremity ulcerations in high-risk patients with end-stage ischemia.
Crew
J R
JR
San Francisco Wound Care Center, Daly City, California 94015 USA.
Thuener
M
M
D000368:Aged; D000800:Angioplasty, Balloon; D001157:Arterial Occlusive Diseases / Q000628:therapy; D017073:Atherectomy; D002908:Chronic Disease; D006801:Humans; D007083:Iliac Artery; D007511:Ischemia / Q000628:therapy*; D007866:Leg / Q000098:blood supply*; D007871:Leg Ulcer / Q000628:therapy*; D012189:Retrospective Studies; D015607:Stents; D016896:Treatment Outcome; D014945:Wound Healing