title: Computer-controlled infusion of propofol for long neurosurgical procedures.
abstract: This study evaluated the performance of a computer-controlled infusion (CCI) system for propofol during long neurosurgical procedures. Anesthesia was induced and maintained in 15 patients using a CCI of propofol. The initial target concentration was set at 3 micrograms/ml, and this was then titrated according to the clinical situation. A total of 284 blood samples were taken for propofol assay. The performance of the system during anesthesia, assessed using the median performance error (MDPE), median absolute performance error (MDAPE), wobble, and divergence, were -5.3%, 20.6%, 9.0%, and 0.3%/h, respectively. MDPE and MDAPE during the first 20 min after stopping the infusion were -38.7% and 39.0%, respectively. The CCI system did not show significant changes in predictive ability, with time during anesthesia lasting up to 12 h. Changes in the measured blood concentration were in the same direction as changes in the target concentration.
authors.affiliation: Department of Anaesthesia and Intensive Care, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong.
authors.forename: T A
authors.initials: TA
authors.lastname: Lim
authors.forename: T
authors.initials: T
authors.lastname: Gin
authors.forename: Y H
authors.initials: YH
authors.lastname: Tam
authors.forename: C S
authors.initials: CS
authors.lastname: Aun
authors.forename: T G
authors.initials: TG
authors.lastname: Short
mesh_terms: D000293:Adolescent; D000328:Adult; D000771:Anesthesia, Intravenous; D018686:Anesthetics, Intravenous / Q000008:administration & dosage; D001784:Blood Gas Analysis; D005260:Female; D005283:Fentanyl; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008874:Midazolam; D008875:Middle Aged; D009493:Neurosurgery / Q000379:methods*; D015742:Propofol / Q000008:administration & dosage; D011880:Radiotherapy Planning, Computer-Assisted; D017409:Sufentanil
chemical_list: D018686:Anesthetics, Intravenous; D017409:Sufentanil; D008874:Midazolam; D005283:Fentanyl; D015742:Propofol