Ethanol preference, metabolism, blood pressure, and conditioned taste aversion in experimental cholestasis.
The effect of a ligation of the common bile duct (BDL) on the chronic free-selection intake of ethanol was investigated. Rats were given a choice between water and a solution of either 6% (v/v) ethanol, 0.06% (w/v) sodium saccharin, or a mixture of both ethanol and saccharin. In different experiments, solutions were first presented either 3 weeks before surgery, about the time of surgery, or 2 weeks after surgery. Reductions in ethanol or saccharin intake were observed in BDL rats whenever the solutions were first presented either 3 weeks before or shortly after the surgery. No differences attributable to BDL were seen when ethanol solutions were first presented 2 weeks after surgery. The contingent nature of the effect suggests that the reduction results from a conditioned taste aversion rather than from differences in ethanol metabolism, sensitivity, or neurohormones such as angiotensin. The findings urge caution in the monitoring of the dietary habits of patients with a rapidly developing biliary obstruction.
Lane
J R
JR
Department of Psychology, University of Washington, Seattle 98195-1525, USA.
Starbuck
E M
EM
Fitts
D A
DA
D000818:Animals; D001362:Avoidance Learning / Q000502:physiology*; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology*; D001835:Body Weight / Q000187:drug effects; D002779:Cholestasis / Q000097:blood / Q000209:etiology / Q000503:physiopathology*; D003213:Conditioning, Psychological / Q000502:physiology; D004347:Drug Interactions; D000431:Ethanol / Q000494:pharmacology*; D005518:Food Preferences / Q000502:physiology*; D008297:Male; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D012439:Saccharin / Q000494:pharmacology; D013549:Sweetening Agents / Q000494:pharmacology; D013649:Taste / Q000502:physiology*
D013549:Sweetening Agents; D000431:Ethanol; D012439:Saccharin