title: Carcinomatous change in the cranial metastasis from a metastasizing mixed tumor of the salivary gland--case report.
abstract: A 57-year-old female who had had a mixed tumor of the submandibular gland for 30 years presented with a cranial metastasis in the ipsilateral occipital region. Detailed histological examinations of the primary tumor failed to detect any carcinomatous component. In contrast, the metastasis contained a carcinomatous component. This histological discrepancy was confirmed by assessment of the expression of Ki-67 antigen in these tumor specimens and comparison with five typical benign mixed tumors. Cranial metastasis of a histologically benign mixed tumor is extremely rare, and a carcinomatous change in the metastatic tumor is apparently unique.
authors.affiliation: Department of Neurosurgery, Iwate Prefectural Central Hospital, Morioka.
authors.forename: M
authors.initials: M
authors.lastname: Fujimura
authors.forename: T
authors.initials: T
authors.lastname: Sugawara
authors.forename: H
authors.initials: H
authors.lastname: Seki
authors.forename: Y
authors.initials: Y
authors.lastname: Otawara
authors.forename: T
authors.initials: T
authors.lastname: Sakuma
authors.forename: Y
authors.initials: Y
authors.lastname: Nakano
authors.forename: T
authors.initials: T
authors.lastname: Yoshimoto
mesh_terms: D008949:Adenoma, Pleomorphic / Q000473:pathology*; D001932:Brain Neoplasms / Q000556:secondary*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009778:Occipital Lobe; D013365:Submandibular Gland Neoplasms / Q000473:pathology*