[Effect of trental on collagen proteolysis in experimental aseptic infarction of the lone bone].
Dynamics of biochemical parameters of the connective tissue and morphometric parameters of lesion were studied in rabbits with induced embolic aseptic infraction of the femur without and with the trental (pentoxiphylline) treatment. The correlation was found between the pairs of indices: proteolytic activity and bone marrow necrosis volume: collagenase activity and bone cortex remodelling rate: concentration of protein bound with hydroxyproline fraction and endosteal regenerate volume.
Magomedov
S
S
Grigorovskiĭ
V V
VV
D000818:Animals; D001842:Bone and Bones / Q000098:blood supply / Q000187:drug effects* / Q000473:pathology; D003094:Collagen / Q000378:metabolism*; D003238:Connective Tissue / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D004353:Drug Evaluation, Preclinical; D006868:Hydrolysis; D006909:Hydroxyproline / Q000378:metabolism; D007238:Infarction / Q000188:drug therapy* / Q000378:metabolism; D008833:Microcirculation / Q000187:drug effects; D010020:Osteonecrosis / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D010431:Pentoxifylline / Q000494:pharmacology*; D011817:Rabbits
D003094:Collagen; D006909:Hydroxyproline; D010431:Pentoxifylline
Vliianie trentala na proteoliz kollagena pri éksperimental'nom asepticheskom infarkte dlinnoĭ kosti.