AANA journal course: update for nurse anesthetists--serotonin agonists and antagonists: anesthetic implications.
A number of important new pharmacologic agents in widespread clinical use share the ability of manipulate serotonin as their mechanism of action. Drugs as diverse as the antidepressants fluoxetine (Prozac), sertraline (Zoloft), paroxetine (Paxil), and venlafaxine (Effexor); the antimigraine agent sumatriptan (Imitrex); the antiobesity agent dexfenfluramine (Redux); and the antiemetics ondansetron (Zofran) and granisetron (Kytril) are routinely encountered in the perioperative patient. A thorough understanding of the pharmacology, physiologic effects, significant drug interactions and anesthetic implications of serotonin agonists or antagonists is vital for proper anesthetic management of patients receiving these drugs.
Nagelhout
J
J
School of Anesthesia at Kaiser Permanente/California State University, Long Beach, USA.
Beauchamp
C
C
D000758:Anesthesia; D000777:Anesthetics / Q000494:pharmacology*; D004347:Drug Interactions; D006801:Humans; D009719:Nurse Anesthetists; D012702:Serotonin Antagonists / Q000494:pharmacology*; D017366:Serotonin Receptor Agonists / Q000494:pharmacology*
D000777:Anesthetics; D012702:Serotonin Antagonists; D017366:Serotonin Receptor Agonists