Aluminium in antacids and cooking pots and the risk of hip fractures in elderly people.
The relationship between hip fractures and aluminium in antacids and cooking pots was examined in an epidemiological study in Sydney, Australia. A population-based case-control study was conducted and 416 men and women aged 65 years and over were recruited (209 cases and 207 controls). There was a significantly (p < 0.05) increased risk of hip fracture associated with use of aluminium cooking pots at age 20 years: the age- and sex-adjusted odds ratio was 1.9 [95% confidence interval (CI) 1.1-3.2]. No association was detected between risk of hip fracture and current use of aluminium cooking pots or use at age 50. There was some suggestion that long-term use of aluminium-containing antacids might increase the risk of hip fracture: the adjusted odds ratio comparing those who had used aluminium-containing antacids for more than 10 years with those who had never used them was 1.8 (95% CI 0.8-4.1). The findings of this study support the need for further research on the association between oral ingestion of aluminium and risk of hip fracture.
Cumming
R G
RG
Department of Public Health, University of Sydney, NSW, Australia.
Klineberg
R J
RJ
D000368:Aged; D000369:Aged, 80 and over; D000535:Aluminum / Q000009:adverse effects* / Q000032:analysis; D000863:Antacids / Q000008:administration & dosage / Q000009:adverse effects*; D016022:Case-Control Studies; D003296:Cooking / Q000295:instrumentation*; D003430:Cross-Sectional Studies; D005260:Female; D006620:Hip Fractures / Q000139:chemically induced* / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009517:New South Wales / Q000453:epidemiology; D016017:Odds Ratio; D012307:Risk Factors; D012737:Sex Factors
D000863:Antacids; D000535:Aluminum