The Th1/Th2 dichotomy, hsp60 autoimmunity, and type I diabetes.
This paper presents some questions and issues regarding the concept of the Th1/Th2 dichotomy and summarizes results using an hsp60 peptide to treat the spontaneous autoimmune process of diabetes in NOD mice.
Cohen
I R
IR
Department of Immunology, Weismann Institute of Science, Rehovot, Israel.
D000818:Animals; D015551:Autoimmunity; D018834:Chaperonin 60 / Q000276:immunology*; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology*; D051379:Mice; D016688:Mice, Inbred NOD; D018417:Th1 Cells / Q000276:immunology*; D018418:Th2 Cells / Q000276:immunology*
D018834:Chaperonin 60