Predictors of natural killer cell-mediated cytotoxicity deficiency in advanced heart failure secondary to either ischemic or idiopathic dilated cardiomyopathy.
The effect of psychologic variables (situational emotional state and psychiatric diagnosis) and physiologic variables (plasma norepinephrine, decreased cardiac exercise capacity, and elevated pulmonary capillary wedge pressure) on natural killer cell activity was evaluated in 19 patients with advanced heart failure of ischemic or idiopathic origin. Only peak exercise capacity was independently predictive of natural killer cell deficiency.
Doering
L V
LV
UCLA School of Nursing, Los Angeles, California, USA.
Vredevoe
D L
DL
Woo
M A
MA
Fonarow
G C
GC
Skotsko
C
C
Bonavida
B
B
D002311:Cardiomyopathy, Dilated / Q000150:complications; D016022:Case-Control Studies; D017079:Exercise Tolerance; D005260:Female; D006333:Heart Failure / Q000097:blood / Q000209:etiology / Q000276:immunology* / Q000523:psychology; D006801:Humans; D007694:Killer Cells, Natural; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D009638:Norepinephrine / Q000097:blood; D011379:Prognosis
D009638:Norepinephrine