Effect of 5-fluorouracil on interleukin-1 and interleukin-2 receptor expression.
We have studied the effect of anticancer drug 5-fluorouracil on the expression of human Interleukin-1 and Interleukin-2 receptor. In this report, we show that 5-Fluorouracil increases the Interleukin-1 expression upto 2.66 folds without significantly affecting the levels of surface expression of p55 IL-2 receptor on human Peripheral blood mononuclear cells, CD4 and CD8 T cells. On contrary, the drug decreases the levels of Interferon-gamma secretion by upto 42%. In earlier studies we have shown that 5-fluorouracil increases the IL-2 expression both at mRNA and protein levels. Taken together, 5-fluorouracil differentially affects the expression of Interleukin-1, Interferon-gamma and Interleukin-2 receptor.
Balaji
K N
KN
Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, India.
Nayak
R
R
D000963:Antimetabolites / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005472:Fluorouracil / Q000494:pharmacology*; D006801:Humans; D007375:Interleukin-1 / Q000235:genetics / Q000378:metabolism*; D007376:Interleukin-2 / Q000235:genetics / Q000378:metabolism; D007963:Leukocytes, Mononuclear / Q000187:drug effects / Q000378:metabolism; D017471:Receptors, Interferon / Q000187:drug effects / Q000378:metabolism; D015375:Receptors, Interleukin-2 / Q000187:drug effects / Q000378:metabolism*; D000096743:Interferon gamma Receptor
D000963:Antimetabolites; D005472:Fluorouracil; D007375:Interleukin-1; D007376:Interleukin-2; D017471:Receptors, Interferon; D015375:Receptors, Interleukin-2; D000096743:Interferon gamma Receptor