title: Pharmacodynamics of antimicrobial agents and rationale for their dosing.
abstract: Antimicrobial pharmacodynamics are an area of considerable importance in terms of dose regimen optimisation and clinical outcome. The pharmacodynamic properties of penicillins, cephalosporins, carbapenems, quinolones, glycopeptides and aminoglycosides are reviewed; the impact such knowledge may have in the future on how we dose these agents is discussed.
authors.affiliation: Bristol Centre for Antimicrobial Research and Evaluation, Southmead Health Services NHS Trust, UK.
authors.forename: A P
authors.initials: AP
authors.lastname: MacGowan
authors.forename: K E
authors.initials: KE
authors.lastname: Bowker
mesh_terms: D042462:4-Quinolones; D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000494:pharmacology*; D000890:Anti-Infective Agents / Q000008:administration & dosage* / Q000494:pharmacology*; D015780:Carbapenems / Q000008:administration & dosage / Q000494:pharmacology; D002511:Cephalosporins / Q000008:administration & dosage / Q000494:pharmacology; D004334:Drug Administration Schedule; D006020:Glycopeptides; D006801:Humans; D008826:Microbial Sensitivity Tests; D010406:Penicillins / Q000008:administration & dosage / Q000494:pharmacology
chemical_list: D042462:4-Quinolones; D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D015780:Carbapenems; D002511:Cephalosporins; D006020:Glycopeptides; D010406:Penicillins