Associations between HLA-DRB1 alleles and leprosy in an Indonesian population.
To investigate whether the susceptibility to leprosy (type), subclinical infection with Mycobacterium leprae and the antibody response against M. leprae-specific antigens are associated with HLA-DR phenotypes sequence-specific oligonucleotide HLA-DRB1 and DQA1 typing and antibody assays have been performed in 79 leprosy patients (41 TT/BT and 38 LL/BL) and 50 healthy controls from a Javanese population in Yogyakarta, Indonesia. DRB1*02 was associated with LL/BL [odds ratio (OR) 2.54, 95% confidence interval (CI) 0.97-9.78, p = 0.037 and attributable risk (AR) 41.5%] but not with TT/BT leprosy (p > 0.05). HLA-DRB1*12 was negatively associated with leprosy (either LL/BL or TT/BT [OR 0.33-0.35, p < 0.05, prevented fraction (PF) 58.8%-65.3%]. No significant association was found between HLA-DRB1 or DQA1 type, anti-M. leprae antibody level and subclinical infection with M. leprae. These data indicate that in this population susceptibility to lepromatous leprosy is associated with HLA-DRB1*02, while resistance to leprosy is associated with HLA-DRB1*12. These associations are not paralleled with associations of the same HLA types with anti-M. leprae antibody level. Finally, the results of this study also support the notion that infection with M. leprae per se is not associated with HLA-DRB1 or DQA1 alleles.
Soebono
H
H
Department of Dermatology, Gadjah Mada University School of Medicine, Yogyakarta, Indonesia.
Giphart
M J
MJ
Schreuder
G M
GM
Klatser
P R
PR
de Vries
R R
RR
D000483:Alleles; D000942:Antigens, Bacterial / Q000276:immunology; D020022:Genetic Predisposition to Disease; D006683:HLA-DQ Antigens / Q000235:genetics* / Q000276:immunology; D006684:HLA-DR Antigens / Q000235:genetics* / Q000276:immunology; D006650:Histocompatibility Testing; D006801:Humans; D007113:Immunity, Innate / Q000235:genetics; D007214:Indonesia / Q000453:epidemiology; D007918:Leprosy / Q000453:epidemiology / Q000235:genetics* / Q000276:immunology; D015439:Leprosy, Borderline / Q000453:epidemiology / Q000235:genetics / Q000276:immunology; D015440:Leprosy, Lepromatous / Q000453:epidemiology / Q000235:genetics / Q000276:immunology; D015441:Leprosy, Tuberculoid / Q000453:epidemiology / Q000235:genetics / Q000276:immunology; D009166:Mycobacterium leprae / Q000276:immunology; D016017:Odds Ratio; D016133:Polymerase Chain Reaction; D017422:Sequence Analysis, DNA
D000942:Antigens, Bacterial; D006683:HLA-DQ Antigens; D006684:HLA-DR Antigens