title: Guiding ribose methylation of rRNA.
abstract: Eukaryotic rRNAs contain a complex set of ribose-methylated nucleotides. Why are these nucleotides modified and how are they selected? A large family of small nucleolar RNAs (snoRNAs) with long complementarities to sites of rRNA methylation has been recently found to guide such modifications, opening up a direct approach to the study of their elusive function. Ribose methylation can also be targeted to non-rRNA sequences by tailored snoRNA guides, possibly providing a highly selective tool for altering gene expression at the post-transcriptional level.
authors.affiliation: Laboratoire de Biologie Moléculaire Eucaryote du CNRS, Université Paul-Sabatier, Toulouse, France. bachel@ibcg.biotoul.fr
authors.forename: J P
authors.initials: JP
authors.lastname: Bachellerie
authors.forename: J
authors.initials: J
authors.lastname: Cavaillé
mesh_terms: D001483:Base Sequence; D001665:Binding Sites; D008745:Methylation; D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D016372:RNA, Antisense; D012335:RNA, Ribosomal / Q000737:chemistry / Q000378:metabolism*; D012266:Ribose / Q000378:metabolism*
chemical_list: D016372:RNA, Antisense; D012335:RNA, Ribosomal; D012266:Ribose