Treatment of dystrophic epidermolysis bullosa with autologous meshed split-thickness skin grafts and allogeneic cultured keratinocytes.
A 5-year-old boy with dystrophic epidermolysis bullosa (DEB), type generalized mitis, presented with a 2-year-old non-healing skin defect on the presternal and abdominal region. After debridement up to the middle dermis, the defect was grafted with autologous meshed split-thickness grafts from non-involved skin from the thigh and covered with allogeneic keratinocytes. The described method is a valuable therapeutic option in DEB patients who have donor skin areas with a preserved structure of the basement membrane zone.
Verplancke
P
P
Department of Dermatology, University Hospital Gent, Belgium.
Beele
H
H
Monstrey
S
S
Naeyaert
J M
JM
D002478:Cells, Cultured; D002675:Child, Preschool; D016108:Epidermolysis Bullosa Dystrophica / Q000503:physiopathology / Q000601:surgery*; D006801:Humans; D015603:Keratinocytes / Q000637:transplantation*; D008297:Male; D016038:Skin Transplantation / Q000379:methods*; D014182:Transplantation, Autologous / Q000379:methods; D014184:Transplantation, Homologous / Q000379:methods; D014945:Wound Healing / Q000502:physiology