Disorder of bile acid metabolism in children with short bowel syndrome.
The profile of fecal bile acids was examined in 13 children with short bowel syndrome; 7 of the 13 did not have diarrhea and the other 6 had intractable diarrhea. In children without diarrhea, no severe fat malabsorption was recognized, and the content of total bile acids in the feces was within the normal range or slightly higher. The ratio of primary to total bile acids showed various patterns. In children with intractable diarrhea, in contrast, fat malabsorption was observed and the fecal content of total bile acids in these patients was more than ten times higher than that of the control group, primary bile acids accounting for more than 95% of the total bile acids and taurine- or glycine-conjugated bile acids for 10%. In the children with intractable diarrhea, the values for the D-xylose absorption test were lower than the normal range. These results suggested that, in children with short bowel syndrome with diarrhea, the loss of bile acids was strongly associated with a decrease in the actual absorptive surface area of the residual small intestine, and the growth of the normal bacterial flora was disturbed in the residual intestine. Some children with or without diarrhea also had hyper bile acidemia. Ursodeoxycholic acid was not effective for the treatment of hyper bile acidemia or fat malabsorption.
Ohkohchi
N
N
Second Department of Surgery, Tohoku University School of Medicine, Sendai, Japan.
Andoh
T
T
Izumi
U
U
Igarashi
Y
Y
Ohi
R
R
D000293:Adolescent; D001647:Bile Acids and Salts / Q000032:analysis / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D003967:Diarrhea / Q000188:drug therapy; D005223:Fats / Q000032:analysis; D005243:Feces / Q000737:chemistry; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D012778:Short Bowel Syndrome / Q000188:drug therapy / Q000378:metabolism*; D014580:Ursodeoxycholic Acid / Q000627:therapeutic use
D001647:Bile Acids and Salts; D005223:Fats; D014580:Ursodeoxycholic Acid