title: [Treatment with tianeptine for depressive disorders in the elderly].
abstract: Depression is frequent in the elderly but difficult both to diagnose and treat due to a number of distinctive features. Tianeptine is a novel antidepressant with a reverse mode of action to that of the selective serotonin reuptake inhibitors yet with proven efficacy and safety. 63 elderly patients (mean age: 68.8 years; range: 65-80 years) with depressive symptoms (major depression: 55.6%; dysthymia: 44.4%) were included in a 3-month open multicenter study with tianeptine (25 mg daily). 43 patients (68.2%) completed the study. There were no drop-outs due to side-effects. Total Montgomery and Asberg depression rating scale scores were significantly decreased (p < 0.01) on day 14, with a response rate of 76.7%. Improvements were also observed in anxiety and cognitive performance. Side-effects were seen in only 11.7% of patients, with no changes in laboratory or ancillary safety parameters. Tianeptine is thus effective and well tolerated in this category o patient.
authors.affiliation: Hospital Ramón y Cajal, Servicio de Psiquiatría, Madrid.
authors.forename: J
authors.initials: J
authors.lastname: Saiz Ruiz
authors.forename: J M
authors.initials: JM
authors.lastname: Montes
authors.forename: E
authors.initials: E
authors.lastname: Alvarez
authors.forename: S
authors.initials: S
authors.lastname: Cervera
authors.forename: J
authors.initials: J
authors.lastname: Giner
authors.forename: J
authors.initials: J
authors.lastname: Guerrero
authors.forename: F
authors.initials: F
authors.lastname: Dourdil
authors.forename: A
authors.initials: A
authors.lastname: Seva
mesh_terms: D000368:Aged / Q000523:psychology*; D000369:Aged, 80 and over; D000929:Antidepressive Agents, Tricyclic / Q000009:adverse effects / Q000627:therapeutic use*; D003866:Depressive Disorder / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D013841:Thiazepines / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D000929:Antidepressive Agents, Tricyclic; D013841:Thiazepines; C050504:tianeptine
vernacular_title: Tratamiento con tianeptina de trastornos depresivos en el anciano.