Mechanisms of exercise intolerance in congestive heart failure.
A major aim in treating patients with chronic heart failure is to improve exercise capacity and quality of life. Experimental evidence does not support the view that central hemodynamic disturbance is the sole determinant of exercise capacity. Rather, multiple other factors including abnormalities of ventilatory control, the lungs, the peripheral circulation, and skeletal muscle appear to combine to generate symptoms and limit exercise.
Harrington
D
D
Department of Cardiac Medicine, National Heart and Lung Institute, Imperial College of Science, Technology and Medicine, London, UK.
Coats
A J
AJ
D005080:Exercise Test; D006333:Heart Failure / Q000175:diagnosis / Q000503:physiopathology* / Q000534:rehabilitation; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D018482:Muscle, Skeletal / Q000098:blood supply / Q000503:physiopathology; D010101:Oxygen Consumption / Q000502:physiology; D010806:Physical Education and Training; D010807:Physical Endurance / Q000502:physiology*; D011659:Pulmonary Gas Exchange / Q000502:physiology; D014692:Ventilation-Perfusion Ratio / Q000502:physiology