title: Proton spectroscopy of suprasellar tumors in pediatric patients.
abstract: OBJECTIVE
  Magnetic resonance imaging and computed tomography provide good anatomic detail of suprasellar tumors in pediatric patients but are not able to predict histology in many cases. Proton magnetic resonance spectroscopy provides metabolic data that may add to diagnostic specificity. We preoperatively performed localized proton magnetic resonance spectroscopy on pediatric patients with suprasellar tumors and correlated the results with the histological findings. Cyst fluid obtained from patients with craniopharyngiomas was studied with high-resolution magnetic resonance spectroscopy to better understand the in vivo data.
  
  
  METHODS
  Nineteen patients aged 1 to 21 years underwent spectroscopy. Surgical pathological samples were obtained from 14 patients. In each of five patients, the presence of a solid chiasmatic mass in addition to clinical evidence of neurofibromatosis Type I allowed the presumptive diagnosis of chiasmatic astrocytoma. Thus, the study population included 6 patients with craniopharyngiomas, 10 with chiasmatic/hypothalamic astrocytomas, and 3 with pituitary adenomas. The data obtained were compared with those of healthy brain from age-matched participants.
  
  
  RESULTS
  Spectroscopy was specific for the diagnosis. All craniopharyngiomas showed a dominant peak at 1 to 2 ppm, consistent with lactate or lipids, with trace amounts of other metabolites. This was confirmed using high-resolution spectroscopy. Chiasmatic gliomas showed a profile of choline, N-acetylaspartate, and creatine, and the choline:N-acetylaspartate ratio was 2.6 +/- 1.3, compared with 0.7 +/- 0.3 for samples of healthy brain (t test, P = 0.0003). Pituitary adenomas showed only a choline peak or no metabolites at all.
  
  
  CONCLUSIONS
  Proton spectroscopy may be helpful in supplementing standard imaging for the preoperative diagnosis of three types of suprasellar tumors that are common in pediatric patients.
authors.affiliation: Department of Neurosurgery, Children's Hospital of Philadelphia, Pennsylvania, USA.
authors.forename: L N
authors.initials: LN
authors.lastname: Sutton
authors.forename: Z J
authors.initials: ZJ
authors.lastname: Wang
authors.forename: S L
authors.initials: SL
authors.lastname: Wehrli
authors.forename: S
authors.initials: S
authors.lastname: Marwaha
authors.forename: P
authors.initials: P
authors.lastname: Molloy
authors.forename: P C
authors.initials: PC
authors.lastname: Phillips
authors.forename: R A
authors.initials: RA
authors.lastname: Zimmerman
mesh_terms: D000236:Adenoma / Q000175:diagnosis / Q000378:metabolism; D000293:Adolescent; D000328:Adult; D001254:Astrocytoma / Q000175:diagnosis* / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D003390:Cranial Nerve Neoplasms / Q000175:diagnosis* / Q000378:metabolism; D003397:Craniopharyngioma / Q000175:diagnosis / Q000378:metabolism; D006801:Humans; D007029:Hypothalamic Neoplasms / Q000175:diagnosis* / Q000378:metabolism; D007223:Infant; D009682:Magnetic Resonance Spectroscopy; D009897:Optic Chiasm / Q000473:pathology; D010911:Pituitary Neoplasms / Q000175:diagnosis* / Q000378:metabolism; D012658:Sella Turcica