Down-regulation of an established immune response via chemical carcinogen or UVB-altered skin.
The ability to produce antigen-specific down-regulation of an established immune response was investigated in 2,4,6-trinitrochlorobenzene (TNCB)-immune mice by delivery of antigen through chemical carcinogen- or ultraviolet B (UVB)-treated skin. When TNCB-immune mice were treated on the dorsal trunk skin with 7,12-dimethylbenz(a)anthracene (DMBA) followed by TNCB there was an antigen-specific reduction in both contact sensitivity and antibody production. Further, immune mice that received spleen cells from naive syngeneic donors treated with DMBA followed by TNCB also exhibited a reduction in both contact sensitivity and antibody production. In contrast, mice treated with UVB irradiation followed by TNCB had a reduction in contact sensitivity but not antibody production. These results provide evidence that an ongoing immune response can be manipulated by immunization through a modified skin immune system. This may provide a beneficial approach for the treatment of autoimmune disease.
Chen
Y P
YP
Division of Pathology, University of Tasmania, Hobart, Australia.
Woods
G M
GM
Dandie
G W
GW
Muller
H K
HK
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000008:administration & dosage / Q000276:immunology; D000818:Animals; D000917:Antibody Formation; D000941:Antigens / Q000008:administration & dosage; D003877:Dermatitis, Contact / Q000209:etiology / Q000628:therapy; D015536:Down-Regulation; D005260:Female; D007114:Immunization; D007165:Immunosuppression Therapy; D007801:Langerhans Cells / Q000187:drug effects / Q000276:immunology / Q000528:radiation effects; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010853:Picryl Chloride / Q000008:administration & dosage / Q000276:immunology; D012867:Skin / Q000187:drug effects / Q000276:immunology* / Q000528:radiation effects; D014466:Ultraviolet Rays
D000941:Antigens; D015127:9,10-Dimethyl-1,2-benzanthracene; D010853:Picryl Chloride