Cardiovascular and hormonal responses to food ingestion in humans with spinal cord transection.
In sympathetic denervation due to primary autonomic failure, ingestion of food causes a fall in blood pressure (BP) and exacerbates postural hypotension. It is not known whether these responses occur in tetraplegics with physiologically complete cervical spinal cord transection, who also have sympathetic dysfunction because of disruption of descending spinal sympathetic pathways. We, therefore, studied the effect of a liquid meal on BP, heart rate (HR) and neurohormonal levels in tetraplegics. Paraplegics with low lesions and without sympathetic dysfunction served as controls. After food ingestion, there was no fall in BP in tetraplegics or in controls. HR did not change in either group. After fund, plasma noradrenaline was unchanged in tetraplegics, but rose in controls, while plasma renin activity (PRA) rose in tetraplegics but not in controls. The fall in BP and rise in HR on head-up tilt after the meal in tetraplegics was similar to that before the meal. There was no change in PRA following pre-prandial tilt in either group; post-prandial tilt raised levels in the tetraplegics, unlike in controls. Thus there is considerable variance in the responses to food between tetraplegics and paraplegic controls, and even greater differences when compared with published data in other autonomic disorders with sympathetic dysfunction; this may relate to the site and the nature of the sympathetic lesion and the ability to activate compensatory mechanisms.
Baliga
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Department of Medicine, St Mary's Hospital/Imperial College School of Medicine, University of London, UK. baliga@calvin.bwh.harvard.edu
Catz
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Watson
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Frankel
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Mathias
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D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure / Q000502:physiology; D004435:Eating / Q000502:physiology*; D004573:Electrolytes / Q000097:blood; D004837:Epinephrine / Q000097:blood; D006339:Heart Rate / Q000502:physiology; D006439:Hemodynamics / Q000502:physiology*; D006728:Hormones / Q000097:blood*; D006801:Humans; D007024:Hypotension, Orthostatic / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009638:Norepinephrine / Q000097:blood; D009994:Osmolar Concentration; D010264:Paraplegia / Q000097:blood / Q000503:physiopathology; D011782:Quadriplegia / Q000097:blood / Q000503:physiopathology; D012083:Renin / Q000097:blood; D013119:Spinal Cord Injuries / Q000097:blood / Q000503:physiopathology*
D001786:Blood Glucose; D004573:Electrolytes; D006728:Hormones; D012083:Renin; D009638:Norepinephrine; D004837:Epinephrine