Angiotensin converting enzyme gene polymorphism and the risk and extent of ischemic heart disease among Turkish patients.
OBJECTIVE
To evaluate the effects of the angiotensin converting enzyme gene polymorphism on the presence and extent of coronary artery disease and myocardial infarction among Turkish patients.


METHODS
In total 393 consecutive patients undergoing coronary angiography were evaluated for cardiac risk factors including the lipoprotein profile, lipoprotein (a), apoprotein B, and apoprotein A1 levels. The angiotensin converting enzyme genotype was determined by polymerase chain reaction. The extent of coronary atherosclerosis was determined from the angiograms using the Gensini and Leaman scores.


RESULTS
The angiotensin converting enzyme genotype was found not to be associated either with coronary artery disease (odds ratio 0.81, P > 0.05) or with myocardial infarction (odds ratio 1.16, P > 0.05). Exclusion of high-risk individuals failed to reveal any association for these subgroups. Furthermore, there was no association between aneurysm formation and the genotype (P > 0.05). The lipid parameters were also not affected by the genotype (P > 0.05). However, the extent of coronary atherosclerosis determined by the Gensini score was related significantly to the genotype by multivariate analysis (P = 0.007).


CONCLUSIONS
The DD genotype is not associated with coronary artery disease and myocardial infarction among these angiographically assessed Turkish patients, even when low-risk subgroups are analysed. Nonetheless, the extent of coronary atherosclerosis in patients with coronary artery disease is affected by their genotype.
Tokgözoğlu
S L
SL
Department of Cardiology, Hacettepe University Faculty of Medicine, Ankara, Turkey.
Alikaşifoğlu
M
M
Atalar
E
E
Tunçbilek
E
E
Ovünç
K
K
Aksöyek
S
S
Kabakçi
G
G
Anar
B
B
Unsal
I
I
Kes
S
S
D000483:Alleles; D017023:Coronary Angiography; D004247:DNA / Q000032:analysis*; D017931:DNA Primers / Q000737:chemistry; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005787:Gene Frequency; D005819:Genetic Markers; D005838:Genotype; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D015999:Multivariate Analysis; D017202:Myocardial Ischemia / Q000000981:diagnostic imaging / Q000201:enzymology* / Q000453:epidemiology; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D010641:Phenotype; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D015995:Prevalence; D012307:Risk Factors; D014421:Turkey / Q000453:epidemiology
D017931:DNA Primers; D005819:Genetic Markers; D008055:Lipids; D004247:DNA; D007703:Peptidyl-Dipeptidase A