title: Polysialylated N-CAM, chromogranin A and B, and secretogranin II in neuroendocrine tumours of the lung.
abstract: Highly alpha 2-8-sialylated N-CAM (neural cell adhesion molecule) impairs N-CAM-mediated cell adhesion. We investigated polysiaN-CAM immunoreactivity in a range of neuroendocrine lung tumours: 15 typical carcinoids, 21 atypical carcinoids, 2 large cell neuroendocrine carcinomas and 12 small cell lung carcinomas were selected on a morphological basis and by their immunoreactivity for chromogranin A and B and secretogranin II. A progressive loss of chromogranin expression, particularly of chromogranin B, was paralleled by the up-regulation of polysiaN-CAM in histologically more aggressive tumours (P = 0.001). These data support the hypothesis that loss of cell-cell adhesion properties might be a relevant factor in the origin of the aggressivity of lung neuroendocrine tumours.
authors.affiliation: II Department of Pathology, Ospedale S. Paolo, University of Milan School of Medicine, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Patriarca
authors.forename: G
authors.initials: G
authors.lastname: Pruneri
authors.forename: R M
authors.initials: RM
authors.lastname: Alfano
authors.forename: N
authors.initials: N
authors.lastname: Carboni
authors.forename: L
authors.initials: L
authors.lastname: Ermellino
authors.forename: F
authors.initials: F
authors.lastname: Guddo
authors.forename: R
authors.initials: R
authors.lastname: Buffa
authors.forename: A G
authors.initials: AG
authors.lastname: Siccardi
authors.forename: G
authors.initials: G
authors.lastname: Coggi
mesh_terms: D000911:Antibodies, Monoclonal; D053379:Chromogranin A; D002864:Chromogranins / Q000032:analysis*; D006801:Humans; D008175:Lung Neoplasms / Q000737:chemistry* / Q000473:pathology; D019006:Neural Cell Adhesion Molecules / Q000032:analysis* / Q000378:metabolism; D018358:Neuroendocrine Tumors / Q000737:chemistry* / Q000473:pathology; D011506:Proteins / Q000032:analysis*; D015854:Up-Regulation
chemical_list: D000911:Antibodies, Monoclonal; C506150:CHGA protein, human; D053379:Chromogranin A; D002864:Chromogranins; D019006:Neural Cell Adhesion Molecules; D011506:Proteins