Effect of apomorphine on the conflict-induced jumping stereotypy in bank voles.
In conventional laboratory cages, bank voles (Clethrionomys glareolus) develop a jumping up-and-down stereotypy already before the age of one month. Central DA systems are thought to be involved in the expression of these conflict-induced stereotypies (CIS). Stereotypies can also be elicited pharmacologically, most commonly by amphetamine and apomorphine. Hence, administration of apomorphine to jumping bank voles provides the opportunity to compare pharmacologically-induced stereotypies (PHIS) and CIS in that species. A pilot study showed that apomorphine induced stereotyped licking that is qualitatively different from the CIS elicited by captivity. The present study investigated whether apomorphine has an effect on CIS-levels. The lowest dose (0.625 mg/kg) did not elicit licking but neither influenced jumping levels. Higher doses (0.938 and 1.094 mg/kg) lead to the occurrence of licking but also suppressed CIS-levels. However, the discordance in time profiles of licking and jumping argues against a shift from jumping to licking due to further stimulation of already activated DA systems. Therefore, expression of jumping seems to depend on stimulation of other DA receptor subtypes or jumping may even be DA independent.
Vandebroek
I
I
University of Ghent, Department of Neurosurgery, Belgium.
Odberg
F O
FO
D000818:Animals; D001058:Apomorphine / Q000008:administration & dosage / Q000494:pharmacology*; D003411:Arvicolinae; D003220:Conflict, Psychological; D018491:Dopamine Agonists / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D013239:Stereotyped Behavior / Q000187:drug effects* / Q000502:physiology
D018491:Dopamine Agonists; D001058:Apomorphine