Significant decreases of ulinastatin-like immunoreactive substance in the cerebrospinal fluid of patients with dementia.
Studies to elucidate changes in the contents of ulinastatin-like immunoreactive substance (UTIRS) and alpha 1-microglobulin-like immunoreactive substance (alpha 1 MIRS) in cerebrospinal fluid (CSF) of patients with dementia were performed. Levels of UTIRS in the dementia group were significantly (p < 0.01) lower than those in dementia-free subjects. In addition, lower levels of UTIRS were registered in subjects afflicted with a higher severity of dementia. However, the levels of alpha 1 MIRS were not affected in the dementia group compared with dementia-free subjects. Neither UTIRS nor alpha 1 MIRS contents were related to the existence and stages of Parkinson's disease. These results suggest that UTIRS levels in the CSF are associated with the severity of dementia.
Shikimi
T
T
Department of Pharmacology, Shimane Medical University, Japan.
Inagaki
T
T
Ishino
H
H
Kobayashi
S
S
Matsubara
K
K
Okunishi
H
H
Takaori
S
S
D000368:Aged; D000544:Alzheimer Disease / Q000134:cerebrospinal fluid; D003704:Dementia / Q000134:cerebrospinal fluid*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005916:Globulins / Q000134:cerebrospinal fluid; D006023:Glycoproteins / Q000134:cerebrospinal fluid*; D006801:Humans; D008297:Male; D010300:Parkinson Disease / Q000134:cerebrospinal fluid; D014361:Trypsin Inhibitors / Q000134:cerebrospinal fluid*
D005916:Globulins; D006023:Glycoproteins; D014361:Trypsin Inhibitors; C028665:urinastatin