title: [Soft tissue changes in adults with acquired growth hormone deficiency during substitution treatment. A double-blind, randomized, placebo-controlled study after a year of treatment].
abstract: The aim of the study was to assess the influence of growth hormone (GH) on body composition in 29 adult persons with acquired growth hormone deficiency (GHD). The study was a double-blind placebo-controlled study of one year's duration. The treatment consisted of daily subcutaneous injections of GH (2.0 IU/m2, Norditropin) or placebo. Before and after one year's treatment, the patients were hospitalized for measurement of Dual-Energy X-ray Absorptiometry (DXA) in order to assess body composition (Fat mass (FM) + Lean Body Mass (LBM). In addition, fasting serum Insulin-like Growth Factor (IGF-I) was collected. The study showed a 200% increase in serum IGF-I. Regarding LBM a 5.7% increase was seen, and this was primarily due to an increase in LBM of the extremities, whereas FM was reduced by 21.5% mainly located truncally. Our data demonstrate that favorable changes in body composition are maintained during long-term, controlled GH treatment, which loads support to the concept of GH substitution in GH-deficient adults.
authors.affiliation: Odense Universitetshospital, medicinsk endokrinologisk afdeling M.
authors.forename: T B
authors.initials: TB
authors.lastname: Hansen
authors.forename: N
authors.initials: N
authors.lastname: Vahl
authors.forename: J O
authors.initials: JO
authors.lastname: Jørgensen
authors.forename: J S
authors.initials: JS
authors.lastname: Christiansen
authors.forename: C
authors.initials: C
authors.lastname: Hagen
mesh_terms: D015502:Absorptiometry, Photon; D000273:Adipose Tissue / Q000187:drug effects; D000328:Adult; D001823:Body Composition / Q000187:drug effects*; D015519:Bone Density / Q000187:drug effects*; D004311:Double-Blind Method; D005260:Female; D005385:Fingers / Q000033:anatomy & histology; D013006:Growth Hormone / Q000008:administration & dosage* / Q000172:deficiency; D006801:Humans; D007279:Injections, Subcutaneous; D007334:Insulin-Like Growth Factor I / Q000032:analysis; D008297:Male; D008875:Middle Aged
chemical_list: D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone
vernacular_title: Bløddelsvaevsaendringer hos voksne med erhvervet vaeksthormonmangel i substitutionsbehandling. Et dobbeltblindt, randomiseret, placebokontrolleret studie af et tiårs vaeksthormonbehandling.