title: [An autopsy case of multiple myeloma with pineal body and spinal cord dura mater infiltration].
abstract: An autopsy case of multiple myeloma (IgD lambda type) with pineal body and spinal cord dura mater infiltration is reported. The 63-year-old man was diagnosed as multiple myeloma (IgD lambda type). He was treated with melphalan and prednisolone. Extra bone marrow masses developed 1 year after the onset. He died with renal failure. At autopsy there were many extra bone marrow masses including pineal body and dura mater of the thoracic cord. Microscopic examination revealed that those mass lesions consisted of neoplastic plasma cells. Myeloma cells also infiltrated perivascular space near the pineal body, subdural space of the cerebrum and brain stem. The cells were labeled VS 38 c immunohistochemically. We discussed routes of the metastasis to the central nervous system of the multiple myeloma. This case suggests that the way of myeloma cells infiltration to the pineal body is hematogenous metastasis, because pineal body have no blood brain barrier.
authors.affiliation: Department of Geriatrics, Tokyo Medical College, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Umahara
authors.forename: M
authors.initials: M
authors.lastname: Kikawada
authors.forename: H
authors.initials: H
authors.lastname: Arai
authors.forename: T
authors.initials: T
authors.lastname: Iwamoto
authors.forename: M
authors.initials: M
authors.lastname: Takasaki
authors.forename: Y
authors.initials: Y
authors.lastname: Hirabayashi
authors.forename: M
authors.initials: M
authors.lastname: Kudo
authors.forename: K
authors.initials: K
authors.lastname: Tsuchiya
authors.forename: H
authors.initials: H
authors.lastname: Shimada
mesh_terms: D004388:Dura Mater / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000473:pathology*; D009360:Neoplastic Cells, Circulating / Q000473:pathology; D010870:Pineal Gland / Q000473:pathology*