Clinical comparison of radiolocalization of two monoclonal antibodies (mAbs) against the TAG-72 antigen.
Ten patients with colorectal cancer metastases received 125I-B72.3 and 131I-CC49 prior to laparotomy (five patients received 1 mg, and five 20 mg of each mAb). Tumor:serum ratios of 131I-CC49 were better than those of 125I-B72.3 (P < 0.01 at 1 mg; P = 0.05 at 20 mg; P < 0.01 at both doses). All known lesions > or = 1 cm in diameter were visualized at the 20 mg dose. There was no difference in absolute tumor uptake of 125I-B72.3 or 131I-CC49. We conclude that mAb CC49 has better relative uptake in colorectal cancers than mAb B72.3.
Divgi
C R
CR
Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.
Scott
A M
AM
McDermott
K
K
Fallone
P S
PS
Hilton
S
S
Siler
K
K
Carmichael
N
N
Daghighian
F
F
Finn
R D
RD
Cohen
A M
AM
D000310:Adrenal Gland Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary; D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal / Q000493:pharmacokinetics / Q000627:therapeutic use*; D000951:Antigens, Neoplasm / Q000276:immunology*; D015179:Colorectal Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000532:radiotherapy*; D005260:Female; D006023:Glycoproteins / Q000276:immunology*; D006801:Humans; D018796:Immunoconjugates / Q000493:pharmacokinetics / Q000627:therapeutic use*; D007457:Iodine Radioisotopes / Q000493:pharmacokinetics / Q000627:therapeutic use*; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary; D008297:Male; D008875:Middle Aged; D010386:Pelvic Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary; D016499:Radioimmunotherapy; D012008:Recurrence; D015899:Tomography, Emission-Computed, Single-Photon
D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm; D006023:Glycoproteins; D018796:Immunoconjugates; D007457:Iodine Radioisotopes; C047052:tumor-associated antigen 72