Polysialylated N-CAM, chromogranin A and B, and secretogranin II in neuroendocrine tumours of the lung.
Highly alpha 2-8-sialylated N-CAM (neural cell adhesion molecule) impairs N-CAM-mediated cell adhesion. We investigated polysiaN-CAM immunoreactivity in a range of neuroendocrine lung tumours: 15 typical carcinoids, 21 atypical carcinoids, 2 large cell neuroendocrine carcinomas and 12 small cell lung carcinomas were selected on a morphological basis and by their immunoreactivity for chromogranin A and B and secretogranin II. A progressive loss of chromogranin expression, particularly of chromogranin B, was paralleled by the up-regulation of polysiaN-CAM in histologically more aggressive tumours (P = 0.001). These data support the hypothesis that loss of cell-cell adhesion properties might be a relevant factor in the origin of the aggressivity of lung neuroendocrine tumours.
Patriarca
C
C
II Department of Pathology, Ospedale S. Paolo, University of Milan School of Medicine, Italy.
Pruneri
G
G
Alfano
R M
RM
Carboni
N
N
Ermellino
L
L
Guddo
F
F
Buffa
R
R
Siccardi
A G
AG
Coggi
G
G
D000911:Antibodies, Monoclonal; D053379:Chromogranin A; D002864:Chromogranins / Q000032:analysis*; D006801:Humans; D008175:Lung Neoplasms / Q000737:chemistry* / Q000473:pathology; D019006:Neural Cell Adhesion Molecules / Q000032:analysis* / Q000378:metabolism; D018358:Neuroendocrine Tumors / Q000737:chemistry* / Q000473:pathology; D011506:Proteins / Q000032:analysis*; D015854:Up-Regulation
D000911:Antibodies, Monoclonal; C506150:CHGA protein, human; D053379:Chromogranin A; D002864:Chromogranins; D019006:Neural Cell Adhesion Molecules; D011506:Proteins