[Effect of thyroxine on synthesis of ceramide, sphingomyelin and phosphatidylcholine in rat hepatocytes].
The aim of the study was to investigate the role of thyroxine in the regulation of [14C] palmitic acid incorporation into ceramide, sphingomyelin and phosphatidylcholine of hepatocytes isolated from 90-day old rats liver. It was found that in intact cells the label [14C] incorporation was more pronounced for ceramide and phosphatidylcholine. It has been determined that thyroxine activates the sphingolipids synthesis. However, the phosphatidylcholine acylation increases under hormone action only during the first 5 min of hepatocyte incubation and decreases during the following period of incubation.
Natarova
Iu A
IuA
Krasil'nikova
O A
OA
Babenko
N A
NA
D000818:Animals; D002518:Ceramides / Q000096:biosynthesis*; D008099:Liver / Q000166:cytology / Q000378:metabolism*; D008297:Male; D010713:Phosphatidylcholines / Q000096:biosynthesis*; D051381:Rats; D017208:Rats, Wistar; D013109:Sphingomyelins / Q000096:biosynthesis*; D013974:Thyroxine / Q000502:physiology*
D002518:Ceramides; D010713:Phosphatidylcholines; D013109:Sphingomyelins; D013974:Thyroxine
Vliianie tiroksina na sintez tseramida, sfingomielina i fosfatidilkholina v gepatotsitakh krys.