Serum levels of basic fibroblast growth factor in acute myocardial infarction.
As it has been reported that basic fibroblast growth factor (bFGF) is a circulating peptide and bFGF gene expression is increased after myocardial ischemia, this study was designed to investigate the serum levels of bFGF in patients with acute myocardial infarction (AMI). Using a bFGF enzyme-linked immunoassay, bFGF levels were determined in venous blood of 15 patients with AMI on admission, at 10 days, and 30 days after infarction, and of 15 age-matched healthy volunteers who were used as controls. bFGF serum levels on admission were similar to normal values (7.48 +/- 2.3 vs 8.14 +/- 2.9 pg/ml). However, they significantly increased (16.82 +/- 3.4 pg/ml; p <0.05) 10 days after the onset of AMI, and at 30 days they returned to baseline (7.07 +/- 2.9 pg/ml). The increased bFGF levels at the second week post AMI suggest that bFGF plays an important role in mediating the development of coronary collateral circulation after myocardial ischemia in humans.
Cuevas
P
P
Servicio de Histologia, Hospital Ramn y Cajal, Ctra. de Colmenar, km. 9.100, Madrid E-28034, Spain.
Barrios
V
V
Giménez-Gallego
G
G
Martinez-Coso
V
V
Cuevas
B
B
Benavides
J
J
Garcia-Segovia
J
J
Asin-Cardiel
E
E
D005260:Female; D016222:Fibroblast Growth Factor 2 / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood*; D012016:Reference Values; D013997:Time Factors
D016222:Fibroblast Growth Factor 2