title: Effect of activated charcoal on rifampicin absorption in man.
abstract: The effect of activated charcoal (AC) on rifampicin excretion was investigated in six healthy volunteers. On three occasions, at weekly intervals, each subject received a 600 mg rifampicin with 350 ml of water; b+c one and two weeks later, 600 mg of rifampicin plus 7.5 and 15 g AC, respectively, in 350 ml of water as a charcoal slurry. Urinary levels of rifampicin were measured form 1-36 hr after ingestion. Treatment with AC led to 1.2 per cent urinary recovery of rifampicin; decreased excretion rate; and a much lower plateau indicative of reduced absorption.
authors.affiliation: College of Health Sciences, Nnamdi Azikiwe University Nnewi Campus, Anambra State, Nigeria.
authors.forename: O E
authors.initials: OE
authors.lastname: Orisakwe
authors.forename: C E
authors.initials: CE
authors.lastname: Dioka
authors.forename: A N
authors.initials: AN
authors.lastname: Okpogba
authors.forename: C N
authors.initials: CN
authors.lastname: Orish
authors.forename: S I
authors.initials: SI
authors.lastname: Ofoefule
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000904:Antibiotics, Antitubercular / Q000493:pharmacokinetics / Q000652:urine; D002606:Charcoal / Q000008:administration & dosage / Q000494:pharmacology*; D004347:Drug Interactions; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects*; D007917:Leprostatic Agents / Q000493:pharmacokinetics / Q000652:urine; D008297:Male; D012293:Rifampin / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000652:urine
chemical_list: D000904:Antibiotics, Antitubercular; D007917:Leprostatic Agents; D002606:Charcoal; D012293:Rifampin