The role of O1-antigen in the adhesion to uroepithelial cells of Klebsiella pneumoniae grown in urine.
We obtained mutants devoid of the O1-antigen, the capsular polysaccharide (K antigen) or both from Klebsiella pneumoniae clinical isolates (urinary infection). These mutants were grown in urine, and their ability to fimbriate and to adhere were studied. Mutants lacking the O1-antigen, independently of the other surface molecules (capsule and fimbriae), showed a great decrease in adhesion to these cells.
Merino
S
S
Departamento de Microbiología, Universidad de Barcelona, Spain.
Rubires
X
X
Aguilar
A
A
Tomás
J M
JM
D000942:Antigens, Bacterial / Q000276:immunology; D001422:Bacterial Adhesion / Q000276:immunology*; D002478:Cells, Cultured; D004848:Epithelium / Q000382:microbiology; D005260:Female; D006801:Humans; D007711:Klebsiella pneumoniae / Q000166:cytology* / Q000276:immunology; D019081:O Antigens / Q000276:immunology*; D014556:Urine / Q000382:microbiology
D000942:Antigens, Bacterial; D019081:O Antigens