title: The factor V Leiden mutation (R506Q) is not a major risk factor for migrainous cerebral infarction.
abstract: The etiology of migrainous cerebral infarction is unknown, but may involve prothrombotic coagulation abnormalities. Therefore, we studied resistance to activated protein C and the presence of the Arg506Gln factor V Leiden mutation in 20 patients with migrainous cerebral infarction. Only one heterozygous carrier of the mutation was found, whereas other patients did not carry the mutation. This indicates that the factor V Leiden mutation is not a major risk factor for migrainous cerebral infarction.
authors.affiliation: Department of Neurology, Leiden University Hospital, The Netherlands.
authors.forename: J
authors.initials: J
authors.lastname: Haan
authors.forename: L J
authors.initials: LJ
authors.lastname: Kappelle
authors.forename: H
authors.initials: H
authors.lastname: de Ronde
authors.forename: M D
authors.initials: MD
authors.lastname: Ferrari
authors.forename: R M
authors.initials: RM
authors.lastname: Bertina
mesh_terms: D000293:Adolescent; D000328:Adult; D002544:Cerebral Infarction / Q000209:etiology*; D005165:Factor V / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000150:complications* / Q000235:genetics; D009154:Mutation / Q000235:genetics*; D011486:Protein C; D012307:Risk Factors
chemical_list: D011486:Protein C; C095381:factor V Leiden; D005165:Factor V