title: Apheresis therapy for prolonged red cell aplasia after major ABO-mismatched bone marrow transplantation.
abstract: Two cases of leukemia were treated successfully with apheresis for delayed recovery of erythropoiesis due to antibody-mediated red cell aplasia after ABO-mismatched bone marrow transplantation (BMT). A 25-year-old female (ABO group O) underwent BMT from her brother (group A). Immunoadsorption using Biosynsorb A performed on day 146 after BMT followed by double filtration plasma pheresis (DFPP) reduced anti-A antibody titers from 1:32 to 1:2. Anemia improved dramatically within 2 weeks. A 49-year-old female (group O) underwent BMT from her mother (group A). She was treated with DFPP on day 131 after BMT. Anti-A antibody titers dropped from 1:16 to 1:1 and anemia improved gradually.
authors.affiliation: Third Department of Internal Medicine, Kanazawa University, Ishikawa.
authors.forename: S
authors.initials: S
authors.lastname: Ohta
authors.forename: H
authors.initials: H
authors.lastname: Yokoyama
authors.forename: T
authors.initials: T
authors.lastname: Ise
authors.forename: K
authors.initials: K
authors.lastname: Takasawa
authors.forename: T
authors.initials: T
authors.lastname: Wada
authors.forename: S
authors.initials: S
authors.lastname: Nakao
authors.forename: T
authors.initials: T
authors.lastname: Matsuda
authors.forename: K
authors.initials: K
authors.lastname: Kobayashi
mesh_terms: D000017:ABO Blood-Group System / Q000276:immunology*; D000328:Adult; D001787:Blood Group Incompatibility / Q000150:complications*; D016026:Bone Marrow Transplantation / Q000009:adverse effects* / Q000276:immunology; D005260:Female; D006789:Host vs Graft Reaction / Q000276:immunology*; D006801:Humans; D007163:Immunosorbent Techniques; D007518:Isoantibodies / Q000276:immunology*; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000628:therapy; D015470:Leukemia, Myeloid, Acute / Q000628:therapy; D008297:Male; D008875:Middle Aged; D010956:Plasmapheresis; D012010:Red-Cell Aplasia, Pure / Q000209:etiology / Q000276:immunology / Q000628:therapy*; D014184:Transplantation, Homologous
chemical_list: D000017:ABO Blood-Group System; D007518:Isoantibodies