Antigen presentation: mixing oil and water.
Studies of the cellular immunology and protein structure of human and mouse CD1 proteins reveal these to be a family of antigen-presenting molecules that allow T cells to recognize lipid and glycolipid antigens of microbial pathogens.
Porcelli
S A
SA
Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Brenner
M B
MB
D000818:Animals; D017951:Antigen Presentation / Q000502:physiology*; D018949:Antigens, CD1 / Q000378:metabolism*; D002240:Carbohydrate Sequence; D006801:Humans; D008055:Lipids / Q000737:chemistry / Q000276:immunology; D051379:Mice; D008954:Models, Biological; D008969:Molecular Sequence Data; D015394:Molecular Structure; D013601:T-Lymphocytes / Q000276:immunology
D018949:Antigens, CD1; D008055:Lipids