Susceptibility to type 1 diabetes in the Senegalese population is linked to HLA-DQ and not TAP and LMP genes.
OBJECTIVE
To investigate the frequency of the transporter associated with antigen processing (TAP) and large multifunctional protease (LMP) alleles and their role in the susceptibility to type 1 diabetes, in comparison with the well-known HLA-DQ alleles susceptibility, in Senegalese subjects.


METHODS
Three loci in the TAP/LMP region were analyzed in 92 type 1 diabetic subjects and 117 nondiabetic control subjects by means of polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).


RESULTS
No association was found between the studied polymorphisms of TAP1, TAP2, and LMP2 and type 1 diabetes in the Senegalese population, in contrast to the HLA-DQA1 and DQB1 genes, which were associated with type 1 diabetes.


CONCLUSIONS
Diabetogenic genes in the class II HLA region are located near the DQA1 and DQB1 loci rather than the TAP and LMP loci.
Chauffert
M
M
Laboratoire de Biochimie, Fondation Hôpital Saint-Jospeh, Paris, France.
Cissé
A
A
Chevenne
D
D
You
J F
JF
Michel
S
S
Trivin
F
F
D018528:ATP-Binding Cassette Transporters / Q000235:genetics*; D000293:Adolescent; D000328:Adult; D002648:Child; D004247:DNA / Q000032:analysis; D017931:DNA Primers / Q000737:chemistry; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics* / Q000276:immunology; D010450:Endopeptidases / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005802:Genes, MHC Class II / Q000235:genetics*; D005838:Genotype; D006683:HLA-DQ Antigens / Q000235:genetics* / Q000276:immunology; D006801:Humans; D008285:Major Histocompatibility Complex; D008297:Male; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D012675:Senegal
D018528:ATP-Binding Cassette Transporters; D017931:DNA Primers; D006683:HLA-DQ Antigens; D004247:DNA; D010450:Endopeptidases