title: Generalized drug reaction due to papaya juice in throat lozenges.
abstract: We report the case of a 55-year-old woman without a history of atopic disease or drug allergy who developed a maculopapular symmetric exanthematous rash about 2 days after taking throat lozenges containing papaya juice. Patch tests gave negative reactions to the European standard series but were positive for papaya juice. A solution of 1% papain in water showed a weak and probably irritant reaction, while a 0.1% solution was negative. To our knowledge this is the first case report of systemic contact dermatitis to papaya without papain hypersensitivity.
authors.affiliation: Department of Dermatology, University Hospital Zurich, Switzerland.
authors.forename: D
authors.initials: D
authors.lastname: Iliev
authors.forename: P
authors.initials: P
authors.lastname: Elsner
mesh_terms: D003875:Drug Eruptions / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D004342:Drug Hypersensitivity / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D005260:Female; D006801:Humans; D007827:Laryngitis / Q000188:drug therapy; D008875:Middle Aged; D010206:Papain / Q000009:adverse effects* / Q000627:therapeutic use; D010328:Patch Tests; D010936:Plant Extracts / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D010936:Plant Extracts; D010206:Papain