[Sensitivity and specificity of thyreostimuline (TSH) determination on filter paper for the diagnosis of hypothyroidism in the elderly].
The aim of this study was to measure the prevalence of hypothyroidism in 239 elderly patients and to determine the validity of TSH assay on blood dried on filter paper (spot-test) for the diagnosis of hypothyroidism. The sensitivity and specificity of the spot-test were evaluated in a subgroup of 177 subjects. The prevalence of hypothyroidism was 14.2% (34/239). The spot-test did not give satisfactory results for the diagnosis of hypothyroidism in elderly subjects. Due to the lack of specificity, most of the positive results were false positives and the clinician had to rely on laboratory determination of plasma TSH level to confirm hypothyroidism in half of the patients. We do not recommend the spot-test for the diagnosis of hypothyroidism in the elderly. Laboratory assay of plasma TSH is required for confirming hypothyroidism in the elderly.
Bouchard
C
C
Centre Hospitalier Universitaire de Québec, Sainte-Foy, Canada.
Allard
P
P
Mercier
P
P
St-Laurent
M
M
Dussault
J
J
Puymirat
J
J
D000368:Aged; D006801:Humans; D007037:Hypothyroidism / Q000097:blood* / Q000175:diagnosis; D010209:Paper; D012680:Sensitivity and Specificity; D012698:Serologic Tests / Q000379:methods; D013972:Thyrotropin / Q000097:blood*; D013974:Thyroxine / Q000097:blood
D013972:Thyrotropin; D013974:Thyroxine
Sensibilité et spécificité du dosage de la thyréostimuline (TSH) sur papier filtre pour le diagnostic d'hypothyroïdie chez la personne âgée.