title: In vivo metabolism of the technetium isonitrile complex [Tc(2-ethoxy-2-methyl-1-isocyanopropane)6]+.
abstract: Technetium(2-ethoxy-2-methyl-1-isocyanopropane)6+, [Tc-EIBT] is a complex of technetium(I) structurally similar but slightly more lipophilic than the commercial myocardial perfusion agent Cardiolite [Tc-MIBI]. Tc-EIBI exhibits rapid extraction from the blood into heart, liver, kidney and striated muscle and rapid hepatobiliary clearance. In the guinea pig, unlike Tc-MIBI, this compound is almost completely enzymatically metabolized to numerous cationic complexes containing a mixture of ethyl other and hydroxy isonitrile ligands. Substitution of the ethyl other group for a methyl ether produces an agent that shows selective in vivo metabolism and more rapid clearance from the liver.
authors.affiliation: Department of Radiology, Harvard Medical School, Brigham and Women's Hospital, Boston MA 02115, USA.
authors.forename: E
authors.initials: E
authors.lastname: Barbarics
authors.forename: J F
authors.initials: JF
authors.lastname: Kronauge
authors.forename: C E
authors.initials: CE
authors.lastname: Costello
authors.forename: G A
authors.initials: GA
authors.lastname: Jànoki
authors.forename: B L
authors.initials: BL
authors.lastname: Holman
authors.forename: A
authors.initials: A
authors.lastname: Davison
authors.forename: A G
authors.initials: AG
authors.lastname: Jones
mesh_terms: D000818:Animals; D002851:Chromatography, High Pressure Liquid; D006168:Guinea Pigs; D008297:Male; D009206:Myocardium / Q000378:metabolism; D009570:Nitriles / Q000378:metabolism* / Q000493:pharmacokinetics; D015609:Organotechnetium Compounds / Q000378:metabolism* / Q000493:pharmacokinetics; D010477:Perfusion; D011817:Rabbits; D019275:Radiopharmaceuticals / Q000378:metabolism* / Q000493:pharmacokinetics; D051381:Rats; D011919:Rats, Inbred Strains; D016339:Spectrometry, Mass, Fast Atom Bombardment; D017256:Technetium Tc 99m Sestamibi / Q000378:metabolism / Q000493:pharmacokinetics; D014018:Tissue Distribution
chemical_list: D009570:Nitriles; D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; C105922:technetium Tc 99m ethoxyisobutylisonitrile; D017256:Technetium Tc 99m Sestamibi