Frzb-1, an antagonist of Wnt-1 and Wnt-8, does not block signaling by Wnts -3A, -5A, or -11.
Frzb-1 is a secreted factor that was recently shown to inhibit signaling by Wnts 1 and 8. Frzb-1 contains an amino terminal domain that is homologous to the Drosophila polarity gene frizzled; several other secreted proteins that share this feature have now been identified. These findings raise the question of whether or not Frzb-1 is a general inhibitor of signaling by all Wnts. We show that signaling of Wnts -3A, 5A, and 11 is not blocked by Frzb-1, demonstrating that Frzb-1 can discriminate both between the principle functional Wnt classes that have been proposed and within them.
Wang
S
S
Laboratory of Developmental Biology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA.
Krinks
M
M
Moos
M
M
D000818:Animals; D006023:Glycoproteins / Q000502:physiology*; D047908:Intracellular Signaling Peptides and Proteins; D011506:Proteins / Q000502:physiology*; D011518:Proto-Oncogene Proteins / Q000502:physiology*; D015398:Signal Transduction; D051153:Wnt Proteins; D000071818:Wnt-5a Protein; D051155:Wnt1 Protein; D060508:Wnt3 Protein; D029867:Xenopus Proteins; D014982:Xenopus laevis; D029961:Zebrafish Proteins; D000099274:Frizzled-Related Proteins
D006023:Glycoproteins; D047908:Intracellular Signaling Peptides and Proteins; D011506:Proteins; D011518:Proto-Oncogene Proteins; D051153:Wnt Proteins; D000071818:Wnt-5a Protein; D051155:Wnt1 Protein; D060508:Wnt3 Protein; D029867:Xenopus Proteins; D029961:Zebrafish Proteins; D000099274:Frizzled-Related Proteins; C495249:WNT1 protein, Xenopus; C085389:WNT5A protein, human; C512785:wnt11b protein, Xenopus; C495248:wnt8a protein, Xenopus