title: The baboon as a nonhuman primate model for assessing the effects of maternal immunization with Haemophilus influenzae type b polysaccharide vaccines.
abstract: These studies were performed to assess the utility of the baboon as a nonhuman primate model to evaluate vaccines for use in humans. Specifically, we examined the antibody response of baboons immunized during the third trimester of pregnancy with Haemophilus influenzae type b (Hib) polyribosylribitol phosphate (PRP) conjugate and unconjugated polysaccharide vaccines. Some of the vaccinated mothers failed to respond to a single immunization with unconjugated Hib PRP. Specific Hib PRP immunoglobulin G (IgG) but not IgM antibodies cross the baboon placenta and are detected in the offspring. Higher-titer baboon anti-Hib PRP did not express two previously defined cross-reactive human anti-Hib PRP idiotypes and was biased towards lambda light-chain expression. Spectrotype analysis indicated that baboon anti-Hib PRP was restricted in heterogeneity and oligoclonal.
authors.affiliation: Department of Microbiology and Immunology, University of Oklahoma Health Science Center, Oklahoma City 73190, USA.
authors.forename: M H
authors.initials: MH
authors.lastname: Shearer
authors.forename: A H
authors.initials: AH
authors.lastname: Lucas
authors.forename: P W
authors.initials: PW
authors.lastname: Anderson
authors.forename: K D
authors.initials: KD
authors.lastname: Carey
authors.forename: H B
authors.initials: HB
authors.lastname: Jenson
authors.forename: T C
authors.initials: TC
authors.lastname: Chanh
authors.forename: J R
authors.initials: JR
authors.lastname: Stanley
authors.forename: R C
authors.initials: RC
authors.lastname: Kennedy
mesh_terms: D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood; D016667:Bacterial Capsules; D005260:Female; D018073:Haemophilus Vaccines / Q000276:immunology*; D007114:Immunization; D010215:Papio; D011135:Polysaccharides, Bacterial / Q000276:immunology*; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000276:immunology*; D018074:Vaccines, Conjugate / Q000276:immunology
chemical_list: D000907:Antibodies, Bacterial; D018073:Haemophilus Vaccines; C044237:Haemophilus influenzae type b polysaccharide vaccine; D011135:Polysaccharides, Bacterial; D018074:Vaccines, Conjugate