Adverse drug events in high risk older outpatients.
OBJECTIVE
To describe the prevalence, types, and consequences of adverse drug events (ADEs) in older outpatients with polypharmacy.


METHODS
A cohort study.


METHODS
General Medicine Clinic at the Durham Veterans Affairs Medical Center.


METHODS
A total of 167 high risk (taking > or = 5 scheduled medications) ambulatory older veterans who participated in a year long health service intervention trial.


METHODS
Potential ADEs were identified by asking patients during closeout interviews whether, in the past year, they had experienced any side effects, unwanted reactions, or other problems from any medication. All reported medications and corresponding adverse experiences were assessed for plausibility by a research clinical pharmacist using two standard pharmacological textbooks and categorized by predictability, therapeutic class, and organ system.


RESULTS
Eighty self-reported ADEs involving 72 medications taken by 58 (35%) of 167 patients were textbook confirmed. Seventy-six of 80 (95%) ADEs were classified as Type A (predictable) reactions. Cardiovascular (33.3%) and central nervous system (27.8%) medication classes were most commonly implicated. Gastrointestinal (30%) and central nervous system (28.8%) ADE symptoms were common. Sixty-three percent of patients with ADEs required physician contacts, 10% emergency room visits, and 11% hospitalization. Twenty percent of medications implicated with ADEs required dosage adjustments, and 48% of ADE-related medications were discontinued. No significant differences (P > .05) were observed when ADE reporters (n = 58) and nonreporters (n = 109) were compared.


CONCLUSIONS
Predictable ADEs are common in high risk older outpatients, resulting in considerable medication modification and substantial healthcare utilization.
Hanlon
J T
JT
Center for the Study of Aging and Human Development, Duke University Medical Center, Durham, North Carolina, USA.
Schmader
K E
KE
Koronkowski
M J
MJ
Weinberger
M
M
Landsman
P B
PB
Samsa
G P
GP
Lewis
I K
IK
D000368:Aged; D000553:Ambulatory Care; D002317:Cardiovascular Agents / Q000009:adverse effects; D002491:Central Nervous System Agents / Q000009:adverse effects; D015331:Cohort Studies; D004347:Drug Interactions; D064420:Drug-Related Side Effects and Adverse Reactions; D004630:Emergencies; D005500:Follow-Up Studies; D005544:Forecasting; D005765:Gastrointestinal Agents / Q000009:adverse effects; D006760:Hospitalization; D006801:Humans; D008137:Longitudinal Studies; D004364:Pharmaceutical Preparations / Q000008:administration & dosage; D019338:Polypharmacy; D015995:Prevalence; D012307:Risk Factors
D002317:Cardiovascular Agents; D002491:Central Nervous System Agents; D005765:Gastrointestinal Agents; D004364:Pharmaceutical Preparations