Serum steroids in relation to prostate cancer risk in a case-control study (Greece).
Blood samples were collected from 52 incident cases of histologically confirmed prostate cancer and 52 age- and town of residence-matched healthy controls in Athens, Greece. Samples were analyzed blindly in Boston, Massachusetts (USA) for testosterone (T), estradiol (E2), sex hormone-binding globulin (SHBG), and dihydrotestosterone (DHT). The data were modeled using multiple logistic regression with adjustment for age, height, body mass index (wt/ht2), years of schooling, and mutually among hormones. DHT was associated inversely, significantly, and strongly with the risk of prostate cancer, whereas T was associated marginally positively, and E2 was associated nonsignificantly inversely with the disease. No association was observed in this study with respect to SHBG.
Signorello
L B
LB
Department of Epidemiology and Harvard Center for Cancer Prevention, Harvard School of Public Health, Boston, Massachusetts 02115, USA.
Tzonou
A
A
Mantzoros
C S
CS
Lipworth
L
L
Lagiou
P
P
Hsieh
C
C
Stampfer
M
M
Trichopoulos
D
D
D000368:Aged; D016022:Case-Control Studies; D013196:Dihydrotestosterone / Q000097:blood*; D004958:Estradiol / Q000097:blood*; D006801:Humans; D016015:Logistic Models; D008297:Male; D016017:Odds Ratio; D011471:Prostatic Neoplasms / Q000209:etiology* / Q000473:pathology; D012111:Residence Characteristics; D012307:Risk Factors; D012738:Sex Hormone-Binding Globulin / Q000378:metabolism*; D013739:Testosterone / Q000097:blood*; D014504:Urban Health
D012738:Sex Hormone-Binding Globulin; D013196:Dihydrotestosterone; D013739:Testosterone; D004958:Estradiol