Immunodeficiency after allogeneic bone marrow transplantation in man: the role of antigen presenting cells.
We investigated the proliferative response of donor T cells to phytohemagglutinin (PHA) presented by donor non-T cells in 7 patients after allogeneic bone marrow transplantation. Compared with the cellular response in the healthy marrow donors, T cell proliferation was found to be deficient in every recipient, from 130 to 739 days after grafting. Results of cell mixing experiments showed that the non-T cells of the patients were as capable as healthy donor non-T cells in presenting PHA to normal donor T cells. However, T cells from patients did not proliferate after substituting donor non-T cells for non-T cells from patients. This inability of T cells to proliferate was most likely the result of ineffective interactions among T cell subsets in patients after allogeneic bone marrow transplantation.
Møller
J
J
Department of Internal Medicine B, Frederiksberg Hospital, Copenhagen, Denmark.
Dickmeiss
E
E
Jacobsen
N
N
Svejgaard
A
A
D000293:Adolescent; D000328:Adult; D017951:Antigen Presentation; D000938:Antigen-Presenting Cells / Q000276:immunology*; D016026:Bone Marrow Transplantation / Q000009:adverse effects* / Q000276:immunology*; D002450:Cell Communication / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008213:Lymphocyte Activation; D008297:Male; D010835:Phytohemagglutinins / Q000378:metabolism / Q000494:pharmacology; D016176:T-Lymphocyte Subsets / Q000276:immunology; D014019:Tissue Donors
D010835:Phytohemagglutinins