title: Spx1, a novel X-linked homeobox gene expressed during spermatogenesis.
abstract: Spx1, a novel mouse homeobox gene, encodes a homeodomain characteristic of the paired-like class of homeobox genes and has been mapped to the distal end of the X chromosome. Northern blot hybridization of adult tissues detected high levels of a single Spx1 transcript in the testis. Further analysis by in situ hybridization revealed predominant Spx1 expression within the spermatogonia/preleptotene spermatocytes and round spermatids of spermatogenic stages IV-VII. These expression data suggest SPX1 may play a role in the regulation of spermatogenesis.
authors.affiliation: Children's Hospital Research Foundation, Developmental Biology, Cincinnati, OH 45229, USA.
authors.forename: W W
authors.initials: WW
authors.lastname: Branford
authors.forename: G Q
authors.initials: GQ
authors.lastname: Zhao
authors.forename: M T
authors.initials: MT
authors.lastname: Valerius
authors.forename: M
authors.initials: M
authors.lastname: Weinstein
authors.forename: E H
authors.initials: EH
authors.lastname: Birkenmeier
authors.forename: L B
authors.initials: LB
authors.lastname: Rowe
authors.forename: S S
authors.initials: SS
authors.lastname: Potter
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D018507:Gene Expression Regulation, Developmental; D005801:Genes, Homeobox; D008040:Genetic Linkage; D018398:Homeodomain Proteins / Q000235:genetics*; D008297:Male; D051379:Mice; D008969:Molecular Sequence Data; D011518:Proto-Oncogene Proteins; D013091:Spermatogenesis / Q000235:genetics*; D014157:Transcription Factors; D014960:X Chromosome
chemical_list: C107475:Esx1 protein, mouse; D018398:Homeodomain Proteins; D011518:Proto-Oncogene Proteins; D014157:Transcription Factors