Origins and functions of the chlamydial inclusion.
Chlamydiae dissociate themselves from the endocytic pathway shortly after internalization by actively modifying the vacuole to become fusogenic with sphingomyelin-containing exocytic vesicles. Interaction with this secretory pathway appears to provide a pathogenic mechanism that allows chlamydiae to establish themselves in a site that is not destined to fuse with lysosomes.
Hackstadt
T
T
Host-Parasite Interactions Section, National Institute of Allergy and Infections Diseases, NIH, Rocky Mountain Laboratories, Hamilton, MT 59840, USA. tedvhackstadt@nib.gov
Fischer
E R
ER
Scidmore
M A
MA
Rockey
D D
DD
Heinzen
R A
RA
D001693:Biological Transport, Active; D002462:Cell Membrane / Q000378:metabolism; D002690:Chlamydia Infections / Q000503:physiopathology*; D002692:Chlamydia trachomatis / Q000254:growth & development / Q000502:physiology* / Q000648:ultrastructure; D004705:Endocytosis; D006801:Humans; D002479:Inclusion Bodies / Q000378:metabolism* / Q000382:microbiology; D008561:Membrane Fusion; D008954:Models, Biological