Association of rheumatoid arthritis with an amino acid allelic variation of the T cell receptor.
OBJECTIVE
To investigate allelic variations of T cell receptor residues for a contribution to rheumatoid arthritis (RA) susceptibility.


METHODS
We conducted an RA case-control study involving 1,579 northwest Europeans: 766 patients with erosive and rheumatoid factor-positive disease and 813 control subjects. Productive changes of segments TCRAV6S1, TCRAV7S1, TCRAV8S1, TCRAV10S2, and TCRBV6S1, TCRBV6S7 were investigated by single-strand conformation polymorphisms. The TCRAV8S1 association was confirmed by restriction fragment length polymorphism.


RESULTS
In the systematic study (77 patients and 119 controls), an increase in 1 TCRAV8S1 genotype was found in the RA patients (P = 0.0004). This finding was replicated in 2 further populations, one from France (212 patients and 254 controls) and the other from Britain (477 patients and 440 controls), with a similar odds ratio (OR), which allowed pooling of the data and confirmation of the association (OR 1.3 [95% confidence interval 1.1-1.7], P = 0.008).


CONCLUSIONS
These findings show evidence that TCRA is an RA susceptibility locus.
Cornélis
F
F
INSERM U358 and Université Paris 7-Hôpital Lariboisière, France.
Hardwick
L
L
Flipo
R M
RM
Martinez
M
M
Lasbleiz
S
S
Prud'homme
J F
JF
Tran
T H
TH
Walsh
S
S
Delaye
A
A
Nicod
A
A
Loste
M N
MN
Lepage
V
V
Gibson
K
K
Pile
K
K
Djoulah
S
S
Danzé
P M
PM
Lioté
F
F
Charron
D
D
Weissenbach
J
J
Kuntz
D
D
Bardin
T
T
Wordsworth
B P
BP
D000483:Alleles; D001172:Arthritis, Rheumatoid / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D018807:Polymorphism, Single-Stranded Conformational; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000235:genetics*
D016693:Receptors, Antigen, T-Cell, alpha-beta