title: Sequence and structural features of plant and fungal tyrosinases.
abstract: Tyrosinases from various organisms are compared with respect to enzymatic structure, primary, secondary and tertiary structure, domain structure, Cu binding sites, maturation mechanism and activation mechanism. On the basis of these comparisons, and by using hemocyanin structure as a template, a structure model for the active site of tyrosinases is proposed.
authors.affiliation: Agrotechnological Research Institute (ATO-DLO), Wageningen, The Netherlands.
authors.forename: C W
authors.initials: CW
authors.lastname: van Gelder
authors.forename: W H
authors.initials: WH
authors.lastname: Flurkey
authors.forename: H J
authors.initials: HJ
authors.lastname: Wichers
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D005656:Fungal Proteins / Q000737:chemistry* / Q000378:metabolism*; D005658:Fungi / Q000201:enzymology*; D006801:Humans; D008969:Molecular Sequence Data; D014442:Monophenol Monooxygenase / Q000737:chemistry* / Q000378:metabolism*; D010940:Plant Proteins / Q000737:chemistry* / Q000378:metabolism*; D010944:Plants / Q000201:enzymology*; D011487:Protein Conformation; D017434:Protein Structure, Tertiary; D017386:Sequence Homology, Amino Acid
chemical_list: D005656:Fungal Proteins; D010940:Plant Proteins; D014442:Monophenol Monooxygenase