title: Use of an intravascular T1 contrast agent to improve MR cine myocardial-blood pool definition in man.
abstract: The feasibility of improving myocardial/blood pool contrast in MR cine images through use of an intravascular contrast agent (Ferumoxtran, Advanced Magnetics, Inc., Cambridge, MA) was tested in four subjects. The contrast-to-noise ratio (CNR) demonstrated a trend toward improvement in the short axis and improved significantly in the long axis cine by an average of 128% (P < .05). Image intensity gradients at the myocardial/blood pool interface increased significantly in both the short and long axis (P < .01). It is expected that larger image intensity gradients at the endocardial border should improve the capabilities of automated segmentation algorithms, reducing the uncertainty and need for manual editing.
authors.affiliation: Department of Radiology, University of Minnesota, MN 55305, USA. stillman@sparky.drad.umn.edu
authors.forename: A E
authors.initials: AE
authors.lastname: Stillman
authors.forename: N
authors.initials: N
authors.lastname: Wilke
authors.forename: M
authors.initials: M
authors.lastname: Jerosch-Herold
mesh_terms: D000465:Algorithms; D003287:Contrast Media; D003911:Dextrans; D005240:Feasibility Studies; D052203:Ferrosoferric Oxide; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007091:Image Processing, Computer-Assisted; D007501:Iron; D019028:Magnetic Resonance Imaging, Cine / Q000379:methods*; D058185:Magnetite Nanoparticles; D009206:Myocardium / Q000473:pathology*; D010087:Oxides; D010865:Pilot Projects
chemical_list: D003287:Contrast Media; D003911:Dextrans; D058185:Magnetite Nanoparticles; D010087:Oxides; C097921:ferumoxtran-10; D007501:Iron; D052203:Ferrosoferric Oxide