Biological role of carbamoyl pyridoxal 5'-phosphate.
A new compound, carbamoyl-pyridoxal 5'-phosphate (C-PLP), was synthetized by condensation of pyridoxal 5'-phosphate (PLP) with KCNO. It may be obtained under certain physiological conditions of pH, temperature and concentration of reagents. Formation and degradation of C-PLP are readily reversible chemical reactions, not involving enzymes, at least in rat tissues. However, different considerations suggest that synthesis and breakdown of C-PLP play a biological role in the cell, providing 'protective synthesis' and a 'variable reservoir' of PLP and KCNO, which can be trapped by other proteins, apoenzymes and metabolites, to regulate many cell metabolic functions.
Terzuoli
L
L
Istituto di Biochimica e di Enzimologia, Facolta di Medicina e Chirurgia, Universita de Siena, Italy.
Pizzichini
M
M
Pagani
R
R
Guerranti
R
R
Ponticelli
F
F
Leoncini
R
R
Marinello
E
E
D000818:Animals; D001831:Body Temperature; D002221:Carbamyl Phosphate / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D008099:Liver / Q000378:metabolism; D008297:Male; D011732:Pyridoxal Phosphate / Q000031:analogs & derivatives* / Q000096:biosynthesis / Q000138:chemical synthesis / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
D002221:Carbamyl Phosphate; D011732:Pyridoxal Phosphate