title: The deadly quartet and the insulin resistance syndrome: an historical overview.
abstract: Since the original observations by Vague almost 50 years ago, a massive literature has documented the pathological consequences of upper body or visceral obesity. These consequences likely relate to the presence of hyperinsulinemia. More recently, the presence of hyperinsulinemia has also been recognized in nonobese hypertensives as a feature of the insulin resistance syndrome. This paper will provide an historical overview of the two clinical syndromes.
authors.affiliation: Division of Hypertension, University of Texas Southwestern Medical Center, Dallas 75235-8899, USA.
authors.forename: N M
authors.initials: NM
authors.lastname: Kaplan
mesh_terms: D006801:Humans; D006946:Hyperinsulinism; D006973:Hypertension; D007333:Insulin Resistance