title: Langerhans' cell histiocytosis with thyroid involvement masquerading as thyroid carcinoma.
abstract: A 28-year-old woman was admitted to our Hospital with a chief complaint of progressive gingival swelling and loosening of teeth over about a year. According to past history, she had received total thyroidectomy 2 years previously due to thyromegaly. The thyroidectomy specimen was at first interpreted as 'poorly differentiated carcinoma of the thyroid'. One year ago, she began to be aware of gingival swelling and loosening of teeth. A gum biopsy was taken and the pathologic features were similar to her 'thyroid carcinoma'. Subsequent investigations, including immunohistochemical stain, showed the gum was heavily infiltrated with histiocyte-like Langerhans' cells which were positive for S-100 protein. Ultrastructural examination of the cells under electron microscope revealed many typical intra-cytoplasmic Birbeck granules. Langerhans' cell histiocytosis was diagnosed. Langerhans' cell histiocytosis with thyroid involvement is extremely rare and may run a relatively indolent course. Even on a retrospective examination, it may easily be confused with poorly differentiated carcinoma of the thyroid. We suspect that this error may have been made on other occasions and that the occurrence of this condition may be underreported.
authors.affiliation: Department of Medicine, Veterans General Hospital-Taipei, Taiwan.
authors.forename: W S
authors.initials: WS
authors.lastname: Wang
authors.forename: J H
authors.initials: JH
authors.lastname: Liu
authors.forename: T J
authors.initials: TJ
authors.lastname: Chiou
authors.forename: R K
authors.initials: RK
authors.lastname: Hsieh
authors.forename: C C
authors.initials: CC
authors.lastname: Yen
authors.forename: P M
authors.initials: PM
authors.lastname: Chen
mesh_terms: D000328:Adult; D002277:Carcinoma / Q000473:pathology*; D003937:Diagnosis, Differential; D005260:Female; D006646:Histiocytosis, Langerhans-Cell / Q000473:pathology*; D006801:Humans; D013964:Thyroid Neoplasms / Q000473:pathology*; D013965:Thyroidectomy