title: Cervex-Brush vs. spatula and Cytobrush. A cytohistologic evaluation.
abstract: OBJECTIVE
  To compare the efficacy of two cervical smear instruments, Cervex-Brush and spatula plus Cytobrush.
  
  
  METHODS
  Cervical smears were taken before laser ring biopsies in 213 women, who were randomized for the Cervex-Brush or spatula plus Cytobrush (S+C). The cytologic diagnosis was compared to the histologic diagnosis after laser ring biopsy.
  
  
  RESULTS
  The correlation between cytology and histology showed comparable concordance (54% and 42%) for the two devices. In 130 (74 with Cervex-Brush and 56 S+C) patients, histology revealed moderate dysplasia or more advanced lesions. Those cases were further analyzed for smear failures. Negative smears were found in 13 cases (10 in the Cervex-Brush and 3 in the S+C group). This difference in favor of S+C was not, however, statistically significant. Significantly more false negative smears were found when endocervical cells were absent and in patients 30-39 years of age.
  
  
  CONCLUSIONS
  Modern sampling devices, such as the Cervex-Brush and S+C, seem to be equally efficient in obtaining dysplastic squamous cells. Other factors of importance for nonrepresentative cervical smears should be studied in order to improve efficacy.
authors.affiliation: Department of Gynaecology, Medical Centre Hospital, Orebro, Sweden.
authors.forename: B
authors.initials: B
authors.lastname: Risberg
authors.forename: A
authors.initials: A
authors.lastname: Andersson
authors.forename: C
authors.initials: C
authors.lastname: Zetterberg
authors.forename: B
authors.initials: B
authors.lastname: Nordin
mesh_terms: D000328:Adult; D001706:Biopsy; D002584:Cervix Uteri / Q000473:pathology*; D003581:Cytodiagnosis; D005188:False Negative Reactions; D005260:Female; D006801:Humans; D014626:Vaginal Smears / Q000379:methods*