Invasive fungal infections in lymphoma patients receiving immunotherapy following autologous bone marrow transplantation (ABMT).
Invasive fungal infections are quite rare (1-5%) following conventional ABMT for malignant lymphoma. Two high-risk lymphoma patients (one non-Hodgkin's lymphoma (NHL) and one Hodgkin's disease) underwent ABMT followed by immunotherapy as part of an experimental therapy given to 12 lymphoma patients aiming to prevent relapse following transplantation. The post-immunotherapy course in both patients was complicated by invasive fungal infections (pulmonary mucormycosis and generalized aspergillosis). The association between invasive fungal infection and immunotherapy following ABMT for malignant lymphoma patients is discussed.
Toren
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Department of Bone Marrow Transplantation, Hadassah University Hospital, Jerusalem, Israel.
Or
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Ackerstein
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Nagler
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D000328:Adult; D016026:Bone Marrow Transplantation; D006689:Hodgkin Disease / Q000628:therapy*; D006801:Humans; D007167:Immunotherapy / Q000009:adverse effects*; D008228:Lymphoma, Non-Hodgkin / Q000628:therapy*; D008297:Male; D009181:Mycoses / Q000209:etiology* / Q000503:physiopathology*; D014182:Transplantation, Autologous