title: [The characteristics of peripheral nervous system involvement in Lyme borreliosis in an endemic region of Russia].
abstract: Clinical and laboratory data are available on affection of the peripheral nervous system (PNS) in 27 patients with Lyme-borreliosis (LB) in the endemic region of Russia. PNS disorders arose early, 88.9% of the patients had them within one month of the disease. 9 (37.5%) patients had meningoradiculoneuropathy (MRN) which emerged in the acute period in 77.8% of the patients. Inflammation in the cerebrospinal fluid was registered only in patients with clinical signs of meningitis. MRN developed more frequently in facial nerve neuritis (FNN) than in radiculopathy (RP)-80.0% and 14.3%, respectively, p = 0.01. Intrathecal synthesis of antibodies to B. burgdorferi in combination with pleocytosis was found only in FNN patients (16.7%). In 6 (37.5%) of 16 patients with neuroborreliosis concentrations of C-reactive protein were elevated. Its high level occurred significantly more frequently in RP (83%) than in FNN (17%) (p = 0.05). 5 out of 14 LB patients exhibited high level of Willebrand factor antigen. No clear clinical relations between this value and PNS lesions in LB were found.
authors.forename: N S
authors.initials: NS
authors.lastname: Baranova
authors.forename: O M
authors.initials: OM
authors.lastname: Lesniak
authors.forename: R G
authors.initials: RG
authors.lastname: Obraztsova
authors.forename: V G
authors.initials: VG
authors.lastname: Mel'nikov
authors.forename: E A
authors.initials: EA
authors.lastname: Andreeva
authors.forename: Ia B
authors.initials: IaB
authors.lastname: Beĭkin
authors.forename: E E
authors.initials: EE
authors.lastname: Laĭkovskaia
authors.forename: I T
authors.initials: IT
authors.lastname: Kufko
authors.forename: A A
authors.initials: AA
authors.lastname: Baranov
mesh_terms: D000328:Adult; D000907:Antibodies, Bacterial / Q000032:analysis; D000914:Antibodies, Viral / Q000097:blood; D015748:Borrelia burgdorferi Group / Q000276:immunology; D002097:C-Reactive Protein / Q000032:analysis; D004197:Disease Reservoirs; D004669:Encephalitis Viruses, Tick-Borne / Q000276:immunology; D005260:Female; D006801:Humans; D008193:Lyme Disease / Q000150:complications / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D010523:Peripheral Nervous System Diseases / Q000175:diagnosis* / Q000209:etiology; D012426:Russia; D012698:Serologic Tests / Q000379:methods; D014841:von Willebrand Factor / Q000032:analysis
chemical_list: D000907:Antibodies, Bacterial; D000914:Antibodies, Viral; D014841:von Willebrand Factor; D002097:C-Reactive Protein
vernacular_title: Osobennosti porazheniia perifericheskoĭ nervnoĭ sistemy pri Laĭm-borrelioze v éndemichnom raĭone Rossii.