title: Serum aminoterminal propeptide of type III procollagen (S-PIIINP) and hepatobiliary dysfunction in patients with ulcerative colitis.
abstract: The aim of the study was to estimate the usefulness of measuring the circulating concentration of serum aminoterminal propeptide of type III collagen (S-PIIINP) in screening for hepatobiliary diseases in patients with ulcerative colitis. S-PIIINP was measured in 69 patients with ulcerative colitis and normal liver biochemistry, in 14 patients with ulcerative colitis and elevated catalytic concentration of alkaline phosphatases in serum (S-ALP, EC 3.1.3.1) but without primary sclerosing cholangitis (PSC), and in 20 patients with ulcerative colitis and PSC. The median S-PIIINP was 3.1 micrograms l-1 in patients with ulcerative colitis and normal liver biochemistry, 4.3 micrograms l-1 in patients with ulcerative colitis and hepatobiliary disorder other than PSC and 8.9 micrograms l-1 in those with ulcerative colitis and PSC. When the S-PIIINP cut-off level was set at 5.0 micrograms l-1, 1% of the patients with ulcerative colitis and normal liver biochemistry, 21% of those with hepatobiliary disorder, not PSC, and 90% of the patients with PSC had S-PIIINP values above that concentration. In conclusion, S-PIIINP above 5.0 micrograms l-1 in a patient with ulcerative colitis strongly suggests concomitant PSC.
authors.affiliation: Fourth Department of Surgery, Helsinki University Central Hospital, Finland.
authors.forename: M H
authors.initials: MH
authors.lastname: Leidenius
authors.forename: L T
authors.initials: LT
authors.lastname: Risteli
authors.forename: J P
authors.initials: JP
authors.lastname: Risteli
authors.forename: E I
authors.initials: EI
authors.lastname: Taskinen
authors.forename: I H
authors.initials: IH
authors.lastname: Kellokumpu
authors.forename: K A
authors.initials: KA
authors.lastname: Höckerstedt
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000469:Alkaline Phosphatase / Q000097:blood; D001660:Biliary Tract Diseases / Q000150:complications / Q000175:diagnosis* / Q000378:metabolism; D015415:Biomarkers / Q000097:blood*; D002648:Child; D015209:Cholangitis, Sclerosing / Q000150:complications / Q000175:diagnosis / Q000378:metabolism; D003093:Colitis, Ulcerative / Q000097:blood*; D006801:Humans; D008107:Liver Diseases / Q000150:complications / Q000175:diagnosis* / Q000378:metabolism; D008875:Middle Aged; D010446:Peptide Fragments / Q000097:blood*; D011347:Procollagen / Q000097:blood*
chemical_list: D015415:Biomarkers; D010446:Peptide Fragments; D011347:Procollagen; C041876:procollagen Type III-N-terminal peptide; D000469:Alkaline Phosphatase