Allergic contact dermatitis caused by zinc pyrithione associated with pustular psoriasis.
A case of allergic contact dermatitis to a shampoo containing zinc pyrithione associated with an eruption of pustular psoriasis is reported. The patient had had stable psoriasis for 5 years, and never any other skin disease. Within 1 week she developed severe generalized pustular psoriasis with many lesions where the shampoo was applied. Treatment with cyclosporin, 200 to 300 mg daily, cleared the eruption within 4 weeks, except for psoriasis of the scalp. Extensive patch testing revealed a relevant sensitization to zinc pyrithione. This case illustrates that a generalized pustular psoriasis can be provoked by a substance present in a hair shampoo. Short-term treatment with cyclosporin is valuable in exacerbations of psoriasis caused by allergic contact dermatitis.
Nielsen
N H
NH
Department of Dermatology, Gentofte Hospital, Hellerup, Denmark.
Menné
T
T
D000328:Adult; D016572:Cyclosporine / Q000627:therapeutic use; D017449:Dermatitis, Allergic Contact / Q000188:drug therapy / Q000209:etiology*; D005260:Female; D006203:Hair Preparations / Q000009:adverse effects*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D009942:Organometallic Compounds / Q000009:adverse effects*; D011565:Psoriasis / Q000139:chemically induced* / Q000188:drug therapy / Q000503:physiopathology; D011725:Pyridines / Q000009:adverse effects*; D012536:Scalp Dermatoses / Q000139:chemically induced / Q000188:drug therapy / Q000503:physiopathology; D015032:Zinc / Q000009:adverse effects*
D006203:Hair Preparations; D007166:Immunosuppressive Agents; D009942:Organometallic Compounds; D011725:Pyridines; D016572:Cyclosporine; D015032:Zinc; C010423:pyrithione zinc