title: Factor V Leiden, C > T MTHFR polymorphism and genetic susceptibility to preeclampsia.
abstract: We performed a case-controlled study to investigate whether the FV Leiden mutation and the C > T677 polymorphism of the 5, 10 methylene tetrahydrofolate reductase (MTHFR) are associated with the occurrence of preeclampsia in 96 otherwise healthy preeclamptic women and 129 parous women as controls. FV Leiden carriers were 10 (10.5%) in cases and 3 (2.3%) in controls (OR: 4.9, 95% CI: 1.3-18.3). MTHFR TT homozygotes were 28 (29.8%) in cases and 24 (18.6%) in the control group (OR: 1.8, 95% CI 1.0-3.5). No difference in any of the polymorphisms was found between proteinuric (n = 45) and non-proteinuric (n = 51) patients. Moreover, MTHFR polymorphism does not affect the association between FV Leiden and preeclampsia. In conclusion, FV Leiden mutation and MTHFR TT genotype are associated with the occurrence of preeclampsia, suggesting that, during pregnancy, women carrying these gene variants are prone to develop such a complication.
authors.affiliation: Arteriosclerosis and Thrombosis Unit, I.R.C.C.S. Casa Sollievo della Sofferenza, S.Giovanni R. (FG), Italy.
authors.forename: E
authors.initials: E
authors.lastname: Grandone
authors.forename: M
authors.initials: M
authors.lastname: Margaglione
authors.forename: D
authors.initials: D
authors.lastname: Colaizzo
authors.forename: G
authors.initials: G
authors.lastname: Cappucci
authors.forename: D
authors.initials: D
authors.lastname: Paladini
authors.forename: P
authors.initials: P
authors.lastname: Martinelli
authors.forename: S
authors.initials: S
authors.lastname: Montanaro
authors.forename: G
authors.initials: G
authors.lastname: Pavone
authors.forename: G
authors.initials: G
authors.lastname: Di Minno
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D005165:Factor V / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008875:Middle Aged; D009154:Mutation; D011110:Polymorphism, Genetic; D011225:Pre-Eclampsia / Q000235:genetics*; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000209:etiology; D013762:Tetrahydrofolate Dehydrogenase / Q000235:genetics*
chemical_list: C095381:factor V Leiden; D005165:Factor V; D013762:Tetrahydrofolate Dehydrogenase