A low dose of streptozotocin prevents kainic acid-induced seizures and lethal effects in the rat.
1. The effect of streptozotocin (STZ), a nitric oxide (NO) donor, on kainic acid (KA)-induced neurotoxicity was examined in Sprague-Dawley rats. 2. The administration of KA (8 mg/kg, i.p.) produced significant neurotoxicity accompanied with increased immunoreactivity for Fos-related antigen in the rat hippocampus. 3. Pretreatment with STZ (15 mg/kg, i.m.) significantly blocked the neurotoxicity induced by KA. 4. Thus, the neuroprotective effect of STZ may, at least in part, reflect the role of NO in inhibiting seizures.
Kim
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HC
College of Pharmacy, Kangwon National University, Chunchon, Korea. Kimbc@cc.kangwon.ac.kr
Im
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Jhoo
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WK
Kim
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Wie
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MB
D000818:Animals; D018690:Excitatory Amino Acid Agonists / Q000009:adverse effects*; D006624:Hippocampus / Q000276:immunology; D007608:Kainic Acid / Q000009:adverse effects*; D008297:Male; D009569:Nitric Oxide / Q000502:physiology; D016760:Proto-Oncogene Proteins c-fos / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D012640:Seizures / Q000139:chemically induced / Q000276:immunology / Q000517:prevention & control*; D013311:Streptozocin / Q000627:therapeutic use*
D018690:Excitatory Amino Acid Agonists; D016760:Proto-Oncogene Proteins c-fos; D009569:Nitric Oxide; D013311:Streptozocin; D007608:Kainic Acid