The role of blood rheology in regulating blood pressure.
Review of the role of blood rheology in regulating blood pressure discloses that macromolecular binding to the erythrocyte membrane is a significant factor. Evidence is summarized supporting the thesis that blood viscosity is a prime regulator of blood pressure. Macromolecules may bind to erythrocytes and other macromolecules forming structures that increase blood viscosity when the blood stream flow rate is decreased. Review of the nature and extent of RBC membrane binding and a model for relating these bonds to blood pressure are presented.
London
M
M
Department of Pathology, State University of New York, Health Science Center at Brooklyn 11203, USA.
D000368:Aged; D001783:Blood Flow Velocity; D001794:Blood Pressure / Q000502:physiology*; D001798:Blood Proteins / Q000378:metabolism; D001809:Blood Viscosity; D002118:Calcium / Q000097:blood; D004903:Erythrocyte Aggregation; D004910:Erythrocyte Membrane / Q000378:metabolism; D005260:Female; D018056:Hemorheology; D006801:Humans; D008297:Male; D008954:Models, Biological; D010710:Phosphates / Q000097:blood; D011188:Potassium / Q000097:blood; D011485:Protein Binding; D012964:Sodium / Q000097:blood
D001798:Blood Proteins; D010710:Phosphates; D012964:Sodium; D011188:Potassium; D002118:Calcium