title: Idiopathic thrombocytopenic purpura in a liver transplant recipient with previous primary biliary cirrhosis.
abstract: The loss of immunotolerance has been implicated in the pathogenesis of both primary biliary cirrhosis (PBC) and idiopathic, immune-mediated thrombocytopenic purpura (ITP). An association between these two autoimmune diseases has been well described. We describe a 41-year-old woman in whom ITP developed 457 days after liver transplantation for PBC while receiving immunosuppressive medications sufficient to maintain allograft function. Our case report, the first to describe post-transplant ITP in association with PBC, demonstrates the persistence of the underlying immune dysregulation of PBC after transplantation. The practice of decreasing the dosage of immunosuppressive medication to maintenance levels after transplantation may unmask the effects of this defect in immunotolerance.
authors.affiliation: Department of Medicine, University of British Columbia, British Columbia Transplant Society, Vancouver, Canada.
authors.forename: E M
authors.initials: EM
authors.lastname: Yoshida
authors.forename: L A
authors.initials: LA
authors.lastname: Mandl
authors.forename: S R
authors.initials: SR
authors.lastname: Erb
authors.forename: A B
authors.initials: AB
authors.lastname: Buckley
authors.forename: C H
authors.initials: CH
authors.lastname: Scudamore
authors.forename: N A
authors.initials: NA
authors.lastname: Buskard
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007165:Immunosuppression Therapy / Q000009:adverse effects*; D008105:Liver Cirrhosis, Biliary / Q000276:immunology* / Q000601:surgery*; D016031:Liver Transplantation / Q000276:immunology*; D011183:Postoperative Complications / Q000276:immunology; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000276:immunology*; D013997:Time Factors