Protein secretion: puzzling receptors.
All known sorting receptors for soluble cargo in the secretory pathway are transmembrane proteins. For sorting to the regulated pathway, however, a subpopulation of secretory proteins, associated with the membrane but not membrane-spanning, appears to link cargo and membrane in storage granule biogenesis.
Thiele
C
C
Department of Neurobiology, University of Heidelberg, Germany.
Gerdes
H H
HH
Huttner
W B
WB
D000324:Adrenocorticotropic Hormone / Q000502:physiology; D000818:Animals; D043423:Carboxypeptidase H; D002268:Carboxypeptidases / Q000502:physiology; D003594:Cytoplasmic Granules / Q000502:physiology; D004702:Endocrine Glands / Q000166:cytology / Q000502:physiology; D005088:Exocrine Glands / Q000166:cytology / Q000502:physiology; D006056:Golgi Apparatus / Q000502:physiology; D006801:Humans; D008954:Models, Biological; D009474:Neurons / Q000502:physiology; D011333:Pro-Opiomelanocortin / Q000502:physiology; D011506:Proteins / Q000378:metabolism*; D018160:Receptors, Cytoplasmic and Nuclear / Q000502:physiology*
D011506:Proteins; D018160:Receptors, Cytoplasmic and Nuclear; D011333:Pro-Opiomelanocortin; D000324:Adrenocorticotropic Hormone; D002268:Carboxypeptidases; D043423:Carboxypeptidase H