Structurally homogeneous and heterogeneous synthetic combinatorial libraries.
We have designed and synthesized structurally homogeneous and heterogeneous nonpeptide libraries. Structurally homogeneous libraries are characterized by the presence of one common structural unit, a scaffold, in all library compounds (e.g. cyclopentane, cyclohexane, diketopiperazine, thiazolidine). In structurally heterogeneous libraries different organic reactions (acylation, etherification, reductive amination, nucleophilic displacement) were applied to connect bifunctional building blocks unrelated in structure (aromatic hydroxy acids, aromatic hydroxy aldehydes, amino alcohols, diamines, and amino acids). The focus of this communication is to document the use of bifunctional building blocks for the design and synthesis of structurally heterogeneous libraries of N-(alkoxy acyl)amino acids, N,N'-bis-(alkoxy acyl)diamino acids, N-acylamino ethers, N-(alkoxy acyl)amino alcohols, N-alkylamino ethers, and N-(alkoxy aryl)diamines.
Krchnák
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Selectide Corporation, Hoechst Marion Roussel, Tucson, AZ 85737, USA.
Weichsel
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Cabel
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Flegelova
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Lebl
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D000447:Aldehydes / Q000138:chemical synthesis / Q000737:chemistry; D000605:Amino Alcohols / Q000138:chemical synthesis / Q000737:chemistry; D002625:Chemistry, Organic / Q000379:methods; D019020:Directed Molecular Evolution / Q000379:methods*; D015195:Drug Design; D006880:Hydroxy Acids / Q000138:chemical synthesis / Q000737:chemistry; D015394:Molecular Structure
D000447:Aldehydes; D000605:Amino Alcohols; D006880:Hydroxy Acids