Characterization of the sensitivity to various genotoxic agents of the UVU1-CHO cell line, a double mutant from UV complementation group 1.
The UVU1 CHO cell line, a double mutant of the excision repair complementation group 1 UV4 cell line was characterized by a higher UV sensitivity than its parent (Busch et al (1989) Mutagenesis 4, 349-354). We show here that this mutant is not affected in a UV mutagenic pathway. In addition, the UVU1 cell line is about two-fold more sensitive to N-methyl-N'-nitro-N-nitrosoguanidine treatment than its parent without being more sensitive to cross-linking agents or ionizing radiations.
Lesca
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Institut de Pharmacologie et Biologie Structurale, CNRS, UPR 8221, Toulouse, France.
Vispé
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Defais
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D000477:Alkylating Agents / Q000633:toxicity; D000818:Animals; D016466:CHO Cells / Q000187:drug effects* / Q000528:radiation effects; D002945:Cisplatin / Q000633:toxicity; D006224:Cricetinae; D003432:Cross-Linking Reagents / Q000633:toxicity; D004260:DNA Repair; D004268:DNA-Binding Proteins; D004720:Endonucleases / Q000235:genetics; D005816:Genetic Complementation Test; D007041:Hypoxanthine Phosphoribosyltransferase / Q000235:genetics; D008769:Methylnitronitrosoguanidine / Q000633:toxicity; D016685:Mitomycin / Q000633:toxicity; D016296:Mutagenesis; D009153:Mutagens / Q000633:toxicity*; D011506:Proteins / Q000235:genetics; D014466:Ultraviolet Rays
D000477:Alkylating Agents; D003432:Cross-Linking Reagents; D004268:DNA-Binding Proteins; D009153:Mutagens; D011506:Proteins; D008769:Methylnitronitrosoguanidine; D016685:Mitomycin; D007041:Hypoxanthine Phosphoribosyltransferase; D004720:Endonucleases; D002945:Cisplatin