title: Cadmium accumulation, zinc status, and mineral bioavailability of growing rats fed diets high in zinc with increasing amounts of phytic acid.
abstract: Five groups of individually housed albino rats (n = 7, initial average weight = 48 g) were fed diets based on egg albumen and cornstarch (basal diet 8.2 g Ca, 6.0 g P, 0.7 g Mg, 225 mg Zn, 150 mg Fe, 60 mg Mn, 8 mg Cu, and 5 mg Cd) over a 4-wk period. Group I (control) was fed the basal diet free of phytic acid (PA). In groups II, III, IV, and V, cornstarch was replaced by 3.5, 7.0, 10.5, and 14.0 g sodium phytate/kg diet, respectively. Daily gain, feed efficiency, Zn status (Zn in plasma, femur, testes, liver and kidneys, activity of the plasma alkaline phosphatase) and apparent absorption of Zn, Fe, Cu, and Mn remained unchanged by the different dietary treatments. PA decreased apparent Mg absorption significantly and apparent absorption of Ca in tendency. Increasing the amount of phytate caused a corresponding enhancement of amount of the digestible P. Cd accumulation in the liver was not significantly altered, and kidney Cd accumulation slightly increased owing to PA. In conclusion, it was shown that under conditions of high dietary Zn, PA had only little effect on the carryover of Cd in growing rats.
authors.affiliation: Institute of Animal Nutrition and Nutritional Physiology, Justus Liebig University, Giessen, Germany.
authors.forename: G
authors.initials: G
authors.lastname: Rimbach
authors.forename: J
authors.initials: J
authors.lastname: Pallauf
mesh_terms: D000042:Absorption; D000818:Animals; D001682:Biological Availability; D015415:Biomarkers / Q000097:blood; D002104:Cadmium / Q000378:metabolism* / Q000633:toxicity; D002105:Cadmium Poisoning / Q000188:drug therapy* / Q000517:prevention & control; D003300:Copper / Q000378:metabolism; D004032:Diet; D005269:Femur / Q000187:drug effects / Q000378:metabolism; D007501:Iron / Q000378:metabolism; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008345:Manganese / Q000378:metabolism; D010833:Phytic Acid / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D013047:Specific Pathogen-Free Organisms; D013052:Spectrometry, X-Ray Emission; D013737:Testis / Q000187:drug effects / Q000378:metabolism; D015032:Zinc / Q000097:blood / Q000493:pharmacokinetics* / Q000494:pharmacology
chemical_list: D015415:Biomarkers; D002104:Cadmium; D008345:Manganese; D003300:Copper; D010833:Phytic Acid; D007501:Iron; D015032:Zinc