[Chromatin-protective action of the biologically active preparation BTK-8L in tetrachloromethane and chlorophos poisoning].
Results obtained from the study of the interaction between the phytosteroid preparation (BTK-8L) and fractionated rat liver nuclear chromatin under conditions of the tetrachloromethane and chlorophos intoxications are described. It is shown that preventive injection of BTK-8L to the animals has a partial protective effect on transcriptionally active and repressed liver chromatin. This preparation interacts with chromatin histone proteins binding with them and changes the nucleoprotein complex structure as a results of which the chromatin fraction components become less accessible to the damaging action of tetrachloromethane and chlorophos. The BTK-8L protective effect is exhibited on the DNA replication and transcriptional levels under conditions of tetrachloromethane and chlorophos intoxications.
Levitskiĭ
E L
EL
Gubskiĭ
Iu I
IuI
Primak
R G
RG
Goriushko
A G
AG
Kholodova
Iu D
IuD
Vistunova
I E
IE
Marchenko
A N
AN
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D002252:Carbon Tetrachloride Poisoning / Q000188:drug therapy*; D002843:Chromatin / Q000187:drug effects*; D002868:Chromosomal Proteins, Non-Histone / Q000187:drug effects; D004247:DNA / Q000187:drug effects; D004996:Ethidium; D005456:Fluorescent Dyes; D006657:Histones / Q000187:drug effects; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013256:Steroids / Q000627:therapeutic use*; D014158:Transcription, Genetic / Q000187:drug effects; D014236:Trichlorfon / Q000506:poisoning*
D000975:Antioxidants; C088577:BTK 8L preparation; D002843:Chromatin; D002868:Chromosomal Proteins, Non-Histone; D005456:Fluorescent Dyes; D006657:Histones; D013256:Steroids; D004247:DNA; D014236:Trichlorfon; D004996:Ethidium
Zashchitnoe po otnosheniiu k khromatinu deĭstvie biologicheski aktivnogo kompleksa BTK-8L v usloviiakh intoksikatsii tetrakhlormetanom i khlorofosom.