title: [High-field (3.OT) MR system: advantages in functional analysis].
abstract: In order to elucidate the precise mechanisms underlying higher brain function, investigations need to focus not only on functionality of neuronal networks but also the underlying connectivity. Newly developed magnetic resonance (MR) techniques offer revolutional, non-invasive tools for both functionality and connectivity analysis in humans, namely, BOLD (blood oxygen level dependent) functional magnetic resonance imaging (MRI) and three dimensional anisotropy contrast (3DAC) magnetic resonance axonograpy (MRX). The former technique makes use of changes in regional deoxyhemoglobin concentration associated with brain function, while the latter utilizes directional information of apparent diffusivity observed in axonal fibers. In these critically important but highly demanding imaging techniques, high-field (> or = 3.OT) MR systems possess significant advantages over conventional systems.
authors.affiliation: Department of Integrated Neuroscience, University of Niigata.
authors.forename: T
authors.initials: T
authors.lastname: Nakada
mesh_terms: D001369:Axons / Q000502:physiology; D001921:Brain / Q000033:anatomy & histology / Q000502:physiology*; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000295:instrumentation* / Q000379:methods; D010100:Oxygen / Q000097:blood
chemical_list: D006454:Hemoglobins; C100003:deoxyhemoglobin; D010100:Oxygen