The effects of crude polysaccharide fractions of 4 kinds of kampo-hozai administered orally on nitric oxide production by murine peritoneal macrophages.
In order to characterize the pharmacological role of the crude polysaccharide fraction in kampo-hozai, we chose 4 kinds of kampo-hozai, Shosaiko-to, Daisaiko-to, Hachimi-jio-gan and Hochu-ekki-to, and studied the effects of their crude polysaccharide fractions on nitric oxide (NO) production by 3% thioglycollate-induced murine peritoneal macrophage. Oral administration of these fractions for 7 d augmented lipopolysaccharide (LPS, 0.1-10 micrograms/ml)-induced NO production by peritoneal macrophages. These results suggest the possibility that a crude polysaccharide fraction affect the macrophage function in most kampo-hozai.
Terawaki
K
K
Department of Pharmacognosy and Plant Chemistry, Faculty of Pharmaceutical Sciences, Nagoya City University, Japan.
Nose
M
M
Ogihara
Y
Y
D000284:Administration, Oral; D000818:Animals; D004365:Drugs, Chinese Herbal; D017737:Macrophages, Peritoneal / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008516:Medicine, Chinese Traditional; D051379:Mice; D008813:Mice, Inbred ICR; D009569:Nitric Oxide / Q000096:biosynthesis*; D011134:Polysaccharides / Q000008:administration & dosage / Q000494:pharmacology*
D004365:Drugs, Chinese Herbal; D011134:Polysaccharides; C461320:shosaiko-to; D009569:Nitric Oxide