Effect of medium-chain triglyceride emulsion in total parenteral nutrition on experimental hepatic metastasis in the rat.
BACKGROUND
This study evaluated the effect of total parenteral nutrition (TPN) regimens containing a medium-chain triglyceride (MCT) emulsion on tumor metastasis.


METHODS
Tumor metastasis development was assessed by the number of metastatic foci on the liver surface in rats inoculated with ACL-15 tumor cells via the portal vein. Rats received one of the following TPN regimens: TPN containing an MCT emulsion (group M), in which tricaprylin emulsion served as the MCT and comprised 50% of nonprotein calories (NPC); TPN containing a long-chain triglyceride (LCT) emulsion (group L), in which soybean oil served as the LCT and comprised 50% of NPC; and TPN without lipid emulsion (group G), in which dextrose comprised 100% of NPC.


RESULTS
The number of metastatic foci was greatest in rats receiving TPN containing the MCT emulsion on day 11 after tumor cell inoculation and either 11 days of TPN or 2 days of TPN followed by 9 days standard rat chow.


CONCLUSIONS
TPN containing MCT emulsion increases liver metastasis early in its administration.
Ohkawa
A
A
Department of Surgery, Niigata University School of Medicine, Japan.
Sato
N
N
Hatakeyama
K
K
D000818:Animals; D002210:Caprylates / Q000009:adverse effects; D002784:Cholesterol / Q000097:blood; D005217:Fat Emulsions, Intravenous / Q000009:adverse effects* / Q000627:therapeutic use; D008114:Liver Neoplasms, Experimental / Q000209:etiology* / Q000556:secondary*; D008297:Male; D010289:Parenteral Nutrition, Total; D010743:Phospholipids / Q000097:blood; D051381:Rats; D011916:Rats, Inbred F344; D013024:Soybean Oil / Q000627:therapeutic use; D014280:Triglycerides / Q000008:administration & dosage* / Q000009:adverse effects / Q000097:blood
D002210:Caprylates; D005217:Fat Emulsions, Intravenous; D010743:Phospholipids; D014280:Triglycerides; C003637:tricaprylin; D013024:Soybean Oil; D002784:Cholesterol