title: Phytochemical and biological study of radal Lomatia hirsuta (Proteaceae).
abstract: The anti-inflammatory property of Lomatia hirsuta (Lam.) Diels ex Macbr. (Proteaceae), leaves (radal), a plant used in Chilean traditional medicine for bronchial troubles and asthma, was evaluated. The biological assays showed infusion of L. hirsuta leaves inhibits the inflammation induced by lambda-carrageenan corresponding to a 29.2% anti-inflammatory effect, and to 53.5% of the maximum effect observed with sodium naproxen (4 mg/kg) in the same experimental conditions. The coumarins, umbelliferone and scopoletin, were the major compounds isolated, along with quercetine, rhamnetin and iso-rhamnetin, with minor quantities or quercitrine and no presence of toxic naphthoquinone derivates. These results supported the folk use of L. hirsuta.
authors.affiliation: Department of Pharmacological and Toxicological Chemistry, Faculty of Pharmaceutical and Chemical Sciences, University of Chile, Santiago.
authors.forename: S
authors.initials: S
authors.lastname: Erazo
authors.forename: R
authors.initials: R
authors.lastname: García
authors.forename: N
authors.initials: N
authors.lastname: Backhouse
authors.lastname: Lemus I 1st
authors.forename: C
authors.initials: C
authors.lastname: Delporte
authors.forename: C
authors.initials: C
authors.lastname: Andrade
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000302:isolation & purification / Q000494:pharmacology*; D005260:Female; D006168:Guinea Pigs; D008297:Male; D009288:Naproxen / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D009288:Naproxen