Effect of thermal injury on the adherence of Candida albicans to murine splenic tissue.
In a mouse model of thermal injury, an increase in burn size produced a decrease in the ratio of Candida albicans cells adherent to the marginal zone to those adherent to the white pulp of the spleen, an increase in the number of Candida cells in the circulation and in the kidneys, and an increase in mortality.
Neely
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AN
Shriners Burns Institute, Department of Surgery, University of Cincinnati College of Medicine, Ohio 45229, USA. anneely@JUNO.com
Orloff
M M
MM
Holder
I A
IA
Healy
D P
DP
D000268:Adhesiveness; D000818:Animals; D002056:Burns / Q000382:microbiology*; D002176:Candida albicans / Q000502:physiology*; D005260:Female; D007108:Immune Tolerance; D051379:Mice; D013154:Spleen / Q000382:microbiology*