title: Influence of body mass index on the age-related slope of total and regional bone mineral content.
abstract: The influence of body mass index (BMI) on T scores for total body bone mineral content (TBBMC) and regional bone mineral content (RBMC) was studied in 186 healthy women: 100 postmenopausal, 35 perimenopausal, and 51 premenopausal. The three groups were divided by BMI >25 kg/m2 and BMI <25 kg/m2 and the postmenopausal women were further subdivided by years since menopause (YSM): <10, 10-20, and >20. Tartrate-resistant acid phosphatase (TRAP) concentration was higher in perimenopausal and postmenopausal women with BMI <25 kg/m2 (P < 0.001). T scores for TBBMC and for axial or peripheral RBMC differed (P < 0.05 in all) between women with BMI >25 kg/m2 and BMI <25 kg/m2. The rate of perimenopausal and postmenopausal age-related slope of BMC, as reflected in all measurements, differed with BMI. In the overall group of women, the T score for TBBMC correlated significantly with BMI (r = 0.46, P < 0.0001); this correlation increased when adjusted for age (r = 0.62, P < 0.0001). BMI correlated with TRAP only in postmenopausal women (r = 0.57, P < 0. 0001). Yearly TBBMC decline was twice as high in postmenopausal women with BMI <25 kg/m2 (P = 0.0004) than in those with BMI >25 kg/m2; the decline of trunk RBMC was more significant (P < 0.0001). These findings confirm the influence of BMI and gonadal status on bone mass.
authors.affiliation: Department of Medicine, University of de Alcalá de Henares, 28801 Madrid, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Revilla
authors.forename: L F
authors.initials: LF
authors.lastname: Villa
authors.forename: A
authors.initials: A
authors.lastname: Sánchez-Atrio
authors.forename: E R
authors.initials: ER
authors.lastname: Hernández
authors.forename: H
authors.initials: H
authors.lastname: Rico
mesh_terms: D000135:Acid Phosphatase / Q000378:metabolism; D000328:Adult; D000375:Aging / Q000502:physiology*; D015992:Body Mass Index; D015519:Bone Density; D005260:Female; D006801:Humans; D007527:Isoenzymes / Q000378:metabolism; D008593:Menopause; D008875:Middle Aged; D000071681:Tartrate-Resistant Acid Phosphatase
chemical_list: D007527:Isoenzymes; D000135:Acid Phosphatase; D000071681:Tartrate-Resistant Acid Phosphatase