Pentoxifylline: its influence on the interaction of blood cells with the vessel wall.
PTX counteracts the increased microvessel permeability which is a feature of the inflammatory aspect of atherogenesis. Furthermore, PTX inhibits oxLDL-induced leukocyte adhesion and, via its positive influence over fibrinolysis and anti-aggregatory factors (e.g. prostacyclin), inhibits thrombus formation. PTX thereby preserves the integrity of the walls of the microcirculatory blood vessels, while reducing the likelihood of thrombosis and its potentially life-threatening sequelae.
Seiffge
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Hoechst Marion Roussel, Wiesbaden, Germany.
D000818:Animals; D001808:Blood Vessels / Q000166:cytology / Q000187:drug effects*; D002199:Capillary Permeability / Q000187:drug effects; D008077:Lipoproteins, LDL / Q000378:metabolism / Q000502:physiology; D010084:Oxidation-Reduction; D010431:Pentoxifylline / Q000494:pharmacology*
D008077:Lipoproteins, LDL; D010431:Pentoxifylline