Cisapride poisoning.
A MEDLINE search from 1966-1996 revealed no reports of cisapride poisoning. An 8-mo-old, 8.9 kg girl received 8 mL of cisapride (Propulsid Suspension, 1 mg/mL, Janssen Pharmaceutica, Titusville, NJ) rather than the usual dose of 0.8 mL, resulting in an inadvertent, 10-fold, iatrogenic, dosing error. She developed emesis, hyperactive bowel sounds, abnormal behavior, mild hyperthermia, tachycardia, hypertension, and thrombocytosis. This is the first published report of poisoning with cisapride.
Gibly
R L
RL
Department of Surgery, University of Arizona Health Sciences Center, Tucson 85724-5057, USA.
Walter
F G
FG
Kloster
J
J
Theodorou
A A
AA
Osterloh
J
J
D000284:Administration, Oral; D020117:Cisapride; D004348:Drug Labeling; D062787:Drug Overdose; D005260:Female; D006801:Humans; D007223:Infant; D010277:Parasympathomimetics / Q000506:poisoning*; D010880:Piperidines / Q000506:poisoning*; D011041:Poisoning / Q000628:therapy
D010277:Parasympathomimetics; D010880:Piperidines; D020117:Cisapride