The impact of an egg donor's age and her prior fertility on recipient pregnancy outcome.
OBJECTIVE
To investigate the effect of donor's age and her prior fertility on recipient pregnancy outcome in our donor egg program.


METHODS
Retrospective cohort analysis.


METHODS
Large academic infertility center.


METHODS
A total of 568 fresh ETs were analyzed for the effect of the egg donor's age on pregnancy outcome; a subset of these (n = 185) were analyzed for the effect of the egg donor's prior fertility on pregnancy outcome.


METHODS
Donors were paired with recipients independent of recipient's age and donor's prior fertility status.


METHODS
Recipient clinical pregnancy rates (PRs) and delivery rates for different donor age groups and for nulligravid donors versus donors with proven fertility.


RESULTS
Donors > or = 33 years old were less likely than younger donors to produce clinical pregnancies and deliveries in their recipients (43.5% versus 26.6% and 35.1% versus 22.1%, respectively). However, there was no difference in clinical PRs or delivery rates between nulligravid donors and donors with proven fertility.


CONCLUSIONS
Donors > or = 33 years of age could be excluded from egg donation because of the lower pregnancy potential of their eggs. However, lack of proven fertility in a donor seems to have no negative impact on pregnancy potential.
Faber
B M
BM
Department of Obstetrics and Gynecology, Jones Institute for Reproductive Medicine, Eastern Virginia Medical School, Norfolk, USA.
Mercan
R
R
Hamacher
P
P
Muasher
S J
SJ
Toner
J P
JP
D000328:Adult; D000375:Aging; D015331:Cohort Studies; D004624:Embryo Transfer; D005260:Female; D006801:Humans; D016015:Logistic Models; D018587:Oocyte Donation; D010298:Parity; D011247:Pregnancy; D011256:Pregnancy Outcome; D012189:Retrospective Studies