title: The influence of protein malnutrition on the antifertility action of gossypol in the Trypanosoma brucei-infected rat: some ultrastructural observations from the testis.
abstract: The testes of adult male Wistar rats that were variously protein malnourished, gossypol treated, and/or trypanosome infected (Trypanosoma brucei) were evaluated ultrastructurally. The findings included several necrotic germ cells in the seminiferous epithelium and focal degeneration of Sertoli cells. Leydig cells showed a remarkable paucity of smooth endoplasmic reticulum, and aggregation of mitochondria. These observations were prevalent in those animals that were simultaneously protein-malnourished/gossypol treated/ trypanosome infected, and were either absent or markedly reduced in the other groups. These structural alterations are probably related to increased gossypol availability to the testis and/or represent the additive effects of gossypol and trypanosomes. Such tissue changes could compromise spermatogenesis in affected animals, and suggest that trypanosome infections may exacerbate testicular lesions in the gossypol-treated rat.
authors.affiliation: Department of Veterinary Anatomy, University of Ibadan, Nigeria.
authors.forename: B T
authors.initials: BT
authors.lastname: Akingbemi
authors.forename: T A
authors.initials: TA
authors.lastname: Aire
authors.forename: B O
authors.initials: BO
authors.lastname: Oke
mesh_terms: D000818:Animals; D003272:Contraceptive Agents, Male / Q000633:toxicity*; D006072:Gossypol / Q000633:toxicity*; D008297:Male; D011488:Protein Deficiency / Q000473:pathology*; D051381:Rats; D017208:Rats, Wistar; D013737:Testis / Q000187:drug effects* / Q000648:ultrastructure; D014353:Trypanosomiasis, African / Q000473:pathology*
chemical_list: D003272:Contraceptive Agents, Male; D006072:Gossypol