Selenite nuclear cataract: review of the model.
Selenite overdose cataract, an experimental model of nuclear cataract produced in young rats is reviewed. Topics include procedures for cataract production and assessment, metabolic and molecular changes in the epithelium of the lens, calcium accumulation, activation of calcium-activated protease system, mechanisms for crystallin precipitation, anti-cataract drug testing and relevance to human cataract.
Shearer
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TR
Department of Oral Molecular Biology, Oregon Health Sciences University, Portland, OR 97201, USA. shearert@ohsu.edu
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Fukiage
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Azuma
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D000818:Animals; D002118:Calcium / Q000378:metabolism; D002135:Calcium-Binding Proteins / Q000235:genetics; D002154:Calpain / Q000037:antagonists & inhibitors / Q000235:genetics / Q000502:physiology; D002386:Cataract / Q000139:chemically induced / Q000188:drug therapy / Q000378:metabolism*; D011232:Chemical Precipitation; D003459:Crystallins / Q000378:metabolism; D015853:Cysteine Proteinase Inhibitors / Q000235:genetics; D003598:Cytoskeletal Proteins / Q000187:drug effects / Q000378:metabolism; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D004848:Epithelium / Q000378:metabolism; D005544:Forecasting; D007908:Lens, Crystalline / Q000378:metabolism*; D012333:RNA, Messenger / Q000032:analysis; D051381:Rats; D018038:Sodium Selenite
D002135:Calcium-Binding Proteins; D003459:Crystallins; D015853:Cysteine Proteinase Inhibitors; D003598:Cytoskeletal Proteins; D012333:RNA, Messenger; C033668:calpastatin; D002154:Calpain; D018038:Sodium Selenite; D002118:Calcium