title: Decreased susceptibility to imipenem among penicillin-resistant Streptococcus pneumoniae.
abstract: We assessed the antimicrobial susceptibilities of 59 penicillin-intermediate or penicillin-resistant pneumococci. All strains were susceptible to vancomycin and rifampicin. The frequency of strains with decreased susceptibility to cefotaxime, chloramphenicol, imipenem and meropenem was 15, 31, 47 and 49% respectively. The high percentage of penicillin-intermediate or penicillin-resistant Streptococcus pneumoniae with decreased susceptibility to third-generation cephalosporins, chloramphenicol and carbapenems limits the therapeutic options for the treatment of invasive pneumococcal infections and particularly of meningitis.
authors.affiliation: Department of Infectious Diseases, Children's National Medical Center, Washington, DC 20010-2970, USA.
authors.forename: A
authors.initials: A
authors.lastname: Pikis
authors.forename: J A
authors.initials: JA
authors.lastname: Donkersloot
authors.forename: S
authors.initials: S
authors.lastname: Akram
authors.forename: J M
authors.initials: JM
authors.lastname: Keith
authors.forename: J M
authors.initials: JM
authors.lastname: Campos
authors.forename: W J
authors.initials: WJ
authors.lastname: Rodriguez
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002439:Cefotaxime / Q000494:pharmacology; D015378:Imipenem / Q000494:pharmacology*; D000077731:Meropenem; D008826:Microbial Sensitivity Tests; D010403:Penicillin Resistance; D012293:Rifampin / Q000494:pharmacology; D013296:Streptococcus pneumoniae / Q000145:classification / Q000187:drug effects* / Q000502:physiology; D013845:Thienamycins / Q000494:pharmacology; D014640:Vancomycin / Q000494:pharmacology; D018440:beta-Lactam Resistance
chemical_list: D000900:Anti-Bacterial Agents; D013845:Thienamycins; D014640:Vancomycin; D015378:Imipenem; D000077731:Meropenem; D002439:Cefotaxime; D012293:Rifampin