Hepatosplenic gamma/delta T-cell lymphoma: a report of two cases in immunocompromised patients, associated with isochromosome 7q.
Two cases of peripheral T-cell lymphoma, characterized by hepatosplenic presentation and gamma/delta T-cell receptor phenotype on malignant cells, are reported. Little is known about the chromosomal changes in these peculiar lymphomas. We report the cytogenetic analysis of these two patients. Isochromosome 7q and trisomy 8 were observed. These abnormalities were reported previously in five cases of gamma/delta T-cell lymphoma. These two patients had lymphomatous infiltration of the spleen, liver, bone marrow, and (in one case) lymph nodes. These abnormalities occurred in immunocompromised patients (i.e., immunosuppressive therapy for kidney transplantation and chemotherapy for Hodgkin's disease), without Epstein-Barr virus infection stigmata in tumor cells.
François
A
A
Department of Pathology, University Hospital, Rouen, France.
Lesesve
J F
JF
Stamatoullas
A
A
Comoz
F
F
Lenormand
B
B
Etienne
I
I
Mendel
I
I
Hémet
J
J
Bastard
C
C
Tilly
H
H
D000328:Adult; D015703:Antigens, CD / Q000032:analysis; D001853:Bone Marrow / Q000473:pathology; D002467:Cell Nucleus / Q000473:pathology; D002869:Chromosome Aberrations; D025063:Chromosome Disorders; D002897:Chromosomes, Human, Pair 7; D002898:Chromosomes, Human, Pair 8; D002999:Clone Cells; D003582:Cytogenetics; D003593:Cytoplasm / Q000473:pathology; D015334:Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor / Q000235:genetics* / Q000276:immunology; D006801:Humans; D007108:Immune Tolerance; D016130:Immunophenotyping; D017403:In Situ Hybridization; D007621:Karyotyping; D008113:Liver Neoplasms / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D008198:Lymph Nodes / Q000473:pathology; D016399:Lymphoma, T-Cell / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D008297:Male; D008677:Metaphase; D008938:Mitosis; D013160:Splenic Neoplasms / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D014314:Trisomy
D015703:Antigens, CD