title: 1H-NMR analysis of trimethylamine in urine for the diagnosis of fish-odour syndrome.
abstract: This paper reports the use of proton NMR spectroscopy for the analysis of trimethylamine in the urine of a patient with trimethylaminuria. Analysis of this compound was also performed for other members of his family. Qualitative and quantitative determination of trimethylamine and trimethylamine-N-oxide was simultaneously performed on untreated urine within a few minutes. The application of the method is discussed.
authors.affiliation: Laboratoire de Biochimie, Hôpital Calmette, CHR et U de Lille, France.
authors.forename: S
authors.initials: S
authors.lastname: Maschke
authors.forename: A
authors.initials: A
authors.lastname: Wahl
authors.forename: N
authors.initials: N
authors.lastname: Azaroual
authors.forename: O
authors.initials: O
authors.lastname: Boulet
authors.forename: V
authors.initials: V
authors.lastname: Crunelle
authors.forename: M
authors.initials: M
authors.lastname: Imbenotte
authors.forename: M
authors.initials: M
authors.lastname: Foulard
authors.forename: G
authors.initials: G
authors.lastname: Vermeersch
authors.forename: M
authors.initials: M
authors.lastname: Lhermitte
mesh_terms: D006631:Amine Oxidase (Copper-Containing); D005260:Female; D006801:Humans; D008099:Liver / Q000201:enzymology; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D008661:Metabolism, Inborn Errors / Q000175:diagnosis / Q000235:genetics / Q000652:urine*; D008744:Methylamines / Q000652:urine*; D009812:Odorants; D010084:Oxidation-Reduction; D000587:Oxidoreductases Acting on CH-NH Group Donors / Q000172:deficiency; D011522:Protons
chemical_list: D008744:Methylamines; D011522:Protons; D006631:Amine Oxidase (Copper-Containing); D000587:Oxidoreductases Acting on CH-NH Group Donors; C005855:trimethyloxamine; C023336:trimethylamine