title: Natural classes of treatment response.
abstract: This study examines an approach to identifying patterns of treatment response over time. Treatment response profiles are identified by cluster analyzing a repeated measure of patient performance collected at intervals during treatment. The procedure is demonstrated in Study 1 using monthly urinalysis results of 103 patients entering methadone maintenance treatment. The internal, external, and face validities of derived treatment response profiles are evaluated. A logistic regression model predicting treatment response is then constructed from intake variables found to correspond with the treatment response profiles. Study 2 replicates the procedures on an independent sample. Treatment response profiles facilitate the analysis of treatment response offering advantages over common measures of treatment outcome, such as performance at follow-up, change in performance from treatment entry to follow-up, or performance summed across treatment.
authors.affiliation: Department of Psychiatry, MCP-Hahnemann School of Medicine, Allegheny University of the Health Sciences, Philadelphia, Pennsylvania 19102-1192, USA.
authors.forename: A R
authors.initials: AR
authors.lastname: Morral
authors.forename: M Y
authors.initials: MY
authors.lastname: Iguchi
authors.forename: M A
authors.initials: MA
authors.lastname: Belding
authors.forename: R J
authors.initials: RJ
authors.lastname: Lamb
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D016009:Chi-Square Distribution; D002986:Clinical Trials as Topic / Q000379:methods* / Q000706:statistics & numerical data; D016000:Cluster Analysis; D016001:Confidence Intervals; D005260:Female; D006801:Humans; D016013:Likelihood Functions; D016015:Logistic Models; D008137:Longitudinal Studies; D008297:Male; D008691:Methadone / Q000627:therapeutic use*; D009294:Narcotics / Q000627:therapeutic use*; D016017:Odds Ratio; D009293:Opioid-Related Disorders / Q000534:rehabilitation* / Q000652:urine; D015397:Program Evaluation / Q000379:methods*; D012189:Retrospective Studies; D012494:Sampling Studies; D015813:Substance Abuse Detection / Q000379:methods / Q000592:standards*; D016896:Treatment Outcome
chemical_list: D009294:Narcotics; D008691:Methadone