The activities and subcellular localization of cathepsin B and cysteine proteinase inhibitors in human ovarian carcinoma.
Ovarian carcinomas exhibited a higher cathepsin B activity than did normal ovaries. The plasma membrane fractions of ovarian cancers were enriched in the activities of both cathepsin and cysteine proteinase inhibitors. The ratio of cathepsin to the inhibitors in these fractions was higher at stage IV than at stage III of the disease, classified according to the Federation of International Gynecology and Obstetrics.
Haczyńksa
H
H
Department of Pharmaceutical Biochemistry, Wrocław University of Medicine, Poland.
Gerber
J
J
Osada
J
J
Warwas
M
M
D000293:Adolescent; D000328:Adult; D002277:Carcinoma / Q000378:metabolism* / Q000473:pathology; D002401:Cathepsin B / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism; D002467:Cell Nucleus / Q000378:metabolism; D003546:Cysteine Endopeptidases / Q000378:metabolism*; D005260:Female; D006801:Humans; D008875:Middle Aged; D008928:Mitochondria / Q000378:metabolism; D010051:Ovarian Neoplasms / Q000378:metabolism* / Q000473:pathology
D003546:Cysteine Endopeptidases; D002401:Cathepsin B