Comparative effect of tiaprofenic acid and piroxicam alone and as adjuvants to praziquantel in Schistosoma mansoni infected mice.
Non steroidal anti-inflammatory drugs (NSAIDs) (tiaprofenic acid and piroxicam have been used alone and as adjuvants to praziquantel in treating hepatic granuloma in Schistosoma mansoni infected mice. Granuloma diameter, histamine metabolism, cyclic AMP and PGE2 levels have been measured at the end of treatment. Tiaprofenic acid effectively reduced the size of hepatic granuloma, significantly increased histamine forming capacity, CAMP level and significantly decreased plasma PGE2 level. Piroxicam had no significant effect on granuloma size, significantly decreased histamine forming capacity, CAMP and PGE2 levels. The combined therapy of either of the drugs with praziquantel did not result in an additive effect.
Hegazy
I H
IH
Department of Parasitology, Faculty of Medicine, University of Alexandria, Egypt.
Nassar
S H
SH
Moussa
S M
SM
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D000242:Cyclic AMP / Q000378:metabolism; D015232:Dinoprostone / Q000097:blood; D004359:Drug Therapy, Combination; D005753:Gastric Mucosa / Q000187:drug effects / Q000503:physiopathology; D006099:Granuloma / Q000188:drug therapy / Q000473:pathology; D006636:Histamine Release / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008107:Liver Diseases / Q000188:drug therapy / Q000473:pathology; D051379:Mice; D010894:Piroxicam / Q000627:therapeutic use*; D011223:Praziquantel / Q000627:therapeutic use*; D011422:Propionates / Q000627:therapeutic use*; D012555:Schistosomiasis mansoni / Q000188:drug therapy*; D012556:Schistosomicides / Q000627:therapeutic use*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D011422:Propionates; D012556:Schistosomicides; D010894:Piroxicam; C021270:tiaprofenic acid; D011223:Praziquantel; D000242:Cyclic AMP; D015232:Dinoprostone