The effect of tamol on human mast cell chymase and plasmin.
Tamol is widely used in the therapy of inflammatory dermatoses. It has pronounced astringent properties and is able to inactivate the neutrophil-derived elastase. Since plasminogen activation and release of mast cell chymase may occur in acute dermatitis, we investigated the inhibitory properties of tamol for these enzymes. Tamol proved to be a potent inhibitor of plasmin and mast cell chymase in concentrations relevant for use in dermatotherapy. The inhibition of mast cell chymase and plasmin by tamol was linear and non-competitive. The inactivation of proteolytic enzymes with the capacity to degrade extracellular-matrix proteins may be one of the major clinical effects of tamol in the treatment of acute inflammatory dermatoses.
Wiedow
O
O
Department of Dermatology, University of Kiel, Germany.
Weindler
F
F
Mrowietz
U
U
D053818:Chymases; D005341:Fibrinolysin / Q000037:antagonists & inhibitors*; D006801:Humans; D047348:Hydrolyzable Tannins; D007700:Kinetics; D019272:Leukocyte Elastase / Q000037:antagonists & inhibitors; D008407:Mast Cells / Q000187:drug effects* / Q000201:enzymology*; D012680:Sensitivity and Specificity; D012697:Serine Endopeptidases / Q000187:drug effects* / Q000378:metabolism*; D015842:Serine Proteinase Inhibitors / Q000494:pharmacology*; D012867:Skin / Q000166:cytology / Q000187:drug effects / Q000201:enzymology; D013634:Tannins / Q000494:pharmacology*
D047348:Hydrolyzable Tannins; D015842:Serine Proteinase Inhibitors; D013634:Tannins; C108021:tamol; D012697:Serine Endopeptidases; D019272:Leukocyte Elastase; D053818:Chymases; D005341:Fibrinolysin