A statistically significant sex difference in the number of colony-forming cells from human peripheral blood.
The number of colony-forming cells (CFC) in the peripheral blood (PB) of 43 volunteers was examined using a semisolid clonogenic culture assay. In all, 22 male (age 21-39 years) and 21 female individuals (age 21-39 years) were tested, ten of each group twice to examine the intraindividual variability of colony-forming cells in PB. A statistically significant sex difference in the number of CFC, erythroblastic colonies (BFU-E), and granulocyte/macrophage colonies (CFU-GM) in PB was detected in favor of male individuals. No significant difference between female and male PB was found for the number of CFU-GEMM. The intraindividual variability of CFC and BFU-E was significantly higher in female donors. These results support previous reports by others on a potential influence of sex steroids on hematopoiesis.
Hörner
S
S
III. Medizinische Klinik des Klinikums Mannheim, Fakultät für Klinische Medizin Mannheim der Universität Heidelberg, Germany.
Pasternak
G
G
Hehlmann
R
R
D000728:Androgens / Q000494:pharmacology; D001772:Blood Cell Count / Q000187:drug effects; D003114:Colony-Forming Units Assay; D004967:Estrogens / Q000494:pharmacology; D005260:Female; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D006801:Humans; D008297:Male; D012727:Sex Characteristics; D013234:Stem Cells / Q000166:cytology
D000728:Androgens; D004967:Estrogens