Increased diversity within the HLA-A*66 group: implications for matching in unrelated bone marrow transplantation.
We have identified a new A*66 allele (A*6603) in three related individuals, an Arabic patient suffering from acute myeloid leukemia and two of her relatives. The A*66 alleles differ in three amino acid residues at positions 70, 90 and 163. The closer relationship between A*6602 and A*6603, which only differ at amino acid 70, replacing GLN with HIS, suggests that the alloreactive potential in this mismatch combination is lower than in all other mismatched A*66 donor-recipient combinations, which exhibit two (A*6601 versus A*6602) and three (A*6601 versus A*6603) differences at the pivotal positions, respectively. This emphasizes the potential role of the A*66 subtypes in bone marrow transplantation with alternative donors. For that reasons, allelic subtyping should be considered in donor-recipient matching to identify the kind of disparity.
Binder
T
T
Department of Internal Medicine, Virchow/Klinikum, Humboldt University, Berlin, Germany.
Wehling
J
J
Huhn
D
D
Blasczyk
R
R
D000595:Amino Acid Sequence; D001483:Base Sequence; D016026:Bone Marrow Transplantation; D004247:DNA; D005091:Exons; D005260:Female; D014644:Genetic Variation; D015234:HLA-A Antigens / Q000235:genetics*; D006650:Histocompatibility Testing; D006801:Humans; D007951:Leukemia, Myeloid / Q000235:genetics* / Q000276:immunology; D008969:Molecular Sequence Data; D010802:Phylogeny; D017386:Sequence Homology, Amino Acid; D012689:Sequence Homology, Nucleic Acid
D015234:HLA-A Antigens; D004247:DNA