[Idiopathic interstitial pneumonia associated with a high level of CA19-9 in serum and with CA19-9 in lung tissue].
A 65-year-old man was admitted to our hospital because of mild dyspnea. A chest roentgenogram showed diffuse reticulonodular shadows in both lung fields. The concentration of CA19-9 in serum was high. Pancreatic cancer and other diseases were considered as causes, but no definitive diagnosis could be made. An open-lung biopsy was done, and examination of a specimen resulted in the diagnosis of idiopathic interstitial pneumonia (chronic type). Immunohistochemical staining with anti-CA19-9 antibody was positive. The lumens of microscopic honeycomb structures and fibrotic areas were covered with flattened and cuboidal metaplastic epithelial cells, which stained positively for anti-CA19-9 antibody.
Sugiyama
M
M
First Department of Internal Medicine, Kumanoto University School of Medicine, Japan.
Ito
K
K
Iyonaga
K
K
Yamaguchi
T
T
Doi
T
T
Saita
N
N
Yamasaki
H
H
Kohrogi
H
H
Suga
M
M
Ando
M
M
D000368:Aged; D015415:Biomarkers / Q000032:analysis* / Q000097:blood; D001706:Biopsy; D018395:CA-19-9 Antigen / Q000032:analysis* / Q000097:blood; D006801:Humans; D008168:Lung / Q000276:immunology; D017563:Lung Diseases, Interstitial / Q000175:diagnosis*; D008297:Male
D015415:Biomarkers; D018395:CA-19-9 Antigen