title: Current controversies in the therapeutic approach to early breast cancer in the elderly.
abstract: Over a 7-year period, in 408 patients aged 70 years or more, 413 early breast cancers were treated as follows: quadrantectomy, axillary dissection, and radiotherapy (QUART) in 142 patients, wide lumpectomy plus radiotherapy extended to the axilla in case of palpable nodes (WLRT) in 45 patients and wide lumpectomy alone in 221 patients. Postoperative tamoxifen was given to 251 patients and chemotherapy to 31. Mean follow-up was 54 months. Relapse free survival was similar at 5 years in the three groups (80%); at 10 years it was 80.8% in QUART, 61.3% in WLRT, 51.7% in WL. Locoregional recurrence, as first failure, occurred in 1.4% QUART, 6.5% WLRT and 15.2% WL. In our experience compliance with surgical day-hospital regimen was excellent, while postoperative radiotherapy created some problems, mainly among oldest patients. We support the role of radiotherapy for its positive impact on local control.
authors.affiliation: Divisione di Radioterapia A, Istituto Nazionale Tumori, Milano, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Cerrotta
authors.forename: L
authors.initials: L
authors.lastname: Lozza
authors.forename: R
authors.initials: R
authors.lastname: Kenda
authors.forename: G
authors.initials: G
authors.lastname: Gardani
authors.forename: E
authors.initials: E
authors.lastname: Galante
authors.forename: R
authors.initials: R
authors.lastname: Zucali
mesh_terms: D000367:Age Factors; D000368:Aged; D001943:Breast Neoplasms / Q000532:radiotherapy / Q000628:therapy*; D003131:Combined Modality Therapy; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008197:Lymph Node Excision; D015412:Mastectomy, Segmental; D009364:Neoplasm Recurrence, Local