[Tumoral vascularization: physiopathology and therapeutic prospects].
The Folkman's hypothesis postulates that tumor or metastase development is angiogenesis dependent. Since 1971, several lines of experimental data have supported this hypothesis in particular during the past months. A better understanding of the functional balance existing between positive and negative regulators of endothelial cell proliferation has paved the way to new therapeutic prospects.
Ortéga
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Laboratoire de biologie moléculaire eucaryote, CNRS UPR 9006, Toulouse, France.
Sordello
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Plouët
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D000328:Adult; D043925:Angiogenesis Inducing Agents / Q000276:immunology / Q000378:metabolism; D000818:Animals; D002455:Cell Division / Q000187:drug effects; D016228:Endothelial Growth Factors / Q000235:genetics / Q000276:immunology / Q000494:pharmacology; D004730:Endothelium, Vascular / Q000187:drug effects / Q000473:pathology; D015870:Gene Expression; D006801:Humans; D066298:In Vitro Techniques; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000098:blood supply / Q000188:drug therapy / Q000503:physiopathology; D009374:Neoplasms, Experimental / Q000188:drug therapy; D009389:Neovascularization, Pathologic / Q000235:genetics / Q000503:physiopathology*; D010446:Peptide Fragments / Q000627:therapeutic use
D043925:Angiogenesis Inducing Agents; D016228:Endothelial Growth Factors; D010446:Peptide Fragments
Vascularisation tumorale: physiopathologie et perspectives thérapeutiques.