Comparison of oral and intravenous hydration and diuretic, choice for protecting cisplatin induced nephrotoxicity.
Efficacy of oral hydration was compared with that of traditional intravenous hydration along with comparison of furasemide with mannitol in 65 patients of solid tumours undergoing Cisplatin based anterior chemotherapy. Incidence of reversible uremia was found to be equivalent in the series. Our results suggest superiority of oral hydration and furosemide diuresis owing to cost efficiency and patient comfort.
Dana
R
R
Department of Radiotherapy, Dr. S. N. Medical College, Mathura Das Mathur Hospital, Jodhpur, Rajasthan, India.
Kachhwaha
V S
VS
D000284:Administration, Oral; D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy; D002945:Cisplatin / Q000009:adverse effects* / Q000627:therapeutic use; D004234:Diuretics, Osmotic / Q000627:therapeutic use*; D005440:Fluid Therapy / Q000379:methods*; D005665:Furosemide / Q000627:therapeutic use*; D006801:Humans; D007262:Infusions, Intravenous; D007674:Kidney Diseases / Q000139:chemically induced* / Q000517:prevention & control*; D008353:Mannitol / Q000627:therapeutic use*; D009369:Neoplasms / Q000188:drug therapy
D000970:Antineoplastic Agents; D004234:Diuretics, Osmotic; D008353:Mannitol; D005665:Furosemide; D002945:Cisplatin