[Interaction of mutations of the genes for mutagen sensitivity mei-9, mei-41 and rad201 as affected by ionizing radiation].
Double mutants mei-41D5; rad(2)201G1 and mei-9a; rad(2)201G1 were constructed to study the interaction of these mutations in Drosophila exposed to gamma-rays. mei-9 and mei-41 mutants are sensitive to the lethal effects of a broad spectrum of chemical and physical factors, while rad201 mutants are sensitive only to ionizing radiation. The results obtained showed that the interaction of mei-9 and rad201 mutations is additive and the interaction of mei-41 and rad201 mutations is epistatic. The maternal effect was demonstrated to be characteristic of all mutants tested even when larvae were exposed to radiation at a late stage of development.
Varentsova
E R
ER
Khromykh
Iu M
IuM
D000818:Animals; D002874:Chromosome Mapping; D004330:Drosophila / Q000235:genetics* / Q000254:growth & development / Q000528:radiation effects; D005720:Gamma Rays; D017344:Genes, Insect / Q000528:radiation effects*; D007814:Larva / Q000528:radiation effects; D007928:Lethal Dose 50; D008540:Meiosis / Q000235:genetics*; D009153:Mutagens / Q000633:toxicity*; D009154:Mutation; D011836:Radiation Tolerance / Q000235:genetics*
D009153:Mutagens
Vzaimodeĭstvie mutatsiĭ genov mutagenchuvstvitel'nosti mei-9, mei-41 and rad201 pri deĭstvii ioniziruiushcheĭ radiatsii.