The effects of substituents introduced into 9-aminoacridine on frameshift mutagenicity and DNA binding affinity.
Some derivatives of 9-aminoacridine (1) were synthesized, and their frameshift mutagenicity and DNA binding affinity were studied. The introduction of a methyl group into the acridine ring of 1 reduced the mutagenic activity and the intercalative DNA binding affinity, while the introduction of chlorine increased them. Halogenated derivatives of 1 showed higher toxicity against Salmonella typhimurium TA1537.
Tomosaka
H
H
Department of Biosystem Science, Graduate School of Science and Technology, Niigata University, Japan.
Omata
S
S
Hasegawa
E
E
Anzai
K
K
D000585:Aminacrine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D004247:DNA / Q000378:metabolism*; D016368:Frameshift Mutation; D006219:Halogens / Q000737:chemistry; D008099:Liver / Q000378:metabolism; D008745:Methylation; D009152:Mutagenicity Tests / Q000379:methods; D009153:Mutagens / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D051381:Rats; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics; D013057:Spectrum Analysis / Q000379:methods; D013329:Structure-Activity Relationship
D006219:Halogens; D009153:Mutagens; D000585:Aminacrine; D004247:DNA