title: Intravenous aminophylline increases the degree of saturation of urine with calcium phosphate and struvite.
abstract: This study was designed to assess the effect of i.v. treatment with aminophylline (AMPH) on the risk of calcium phosphate and struvite stone formation. We administered AMPH in doses of 4 mg/kg body weight in 15-min i.v. infusions to 60 infants with clinical symptoms of obstructive bronchitis with dyspnoea. During 3 hours after infusion we observed a significant increase in urine saturation with brushite, octocalcium phosphate and struvite. This rise in urine saturation may increase the risk of kidney stone formation.
authors.affiliation: IInd Clinic of Paediatrics, University School of Medical Science, Poznań, Poland.
authors.forename: A
authors.initials: A
authors.lastname: Siwińska
authors.forename: J
authors.initials: J
authors.lastname: Głuszek
authors.forename: J
authors.initials: J
authors.lastname: Maciejewski
authors.forename: D
authors.initials: D
authors.lastname: Musialik
mesh_terms: D000628:Aminophylline / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D001991:Bronchitis / Q000188:drug therapy; D001993:Bronchodilator Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D002130:Calcium Phosphates / Q000652:urine*; D004417:Dyspnea / Q000188:drug therapy; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007223:Infant; D007262:Infusions, Intravenous; D007669:Kidney Calculi / Q000139:chemically induced* / Q000652:urine; D017616:Magnesium Compounds / Q000652:urine*; D008297:Male; D010710:Phosphates / Q000652:urine*; D012307:Risk Factors; D000069877:Struvite
chemical_list: D001993:Bronchodilator Agents; D002130:Calcium Phosphates; D017616:Magnesium Compounds; D010710:Phosphates; C485828:alpha-tricalcium phosphate; C485830:tetracalcium phosphate; D000628:Aminophylline; C485838:calcium phosphate, monobasic, anhydrous; C020243:calcium phosphate; D000069877:Struvite; C485829:calcium phosphate, dibasic, anhydrous