title: Evaluation of 153Sm-diethylenetriaminepentaacetic acid for radiolabelling of pharmaceutical dosage forms by neutron activation.
abstract: 153Sm-DTPA provides a suitable alternative to 99mTc-DTPA and 111In-DTPA as a water soluble tracer for the evaluation of pharmaceutical preparations. The chelate was handled biologically in a similar way to 99mTc-DTPA and 111In-DTPA. The chelate can be incorporated into the formulation as a non-radioactive excipient and the intact dosage form can then be neutron activated to produce 153Sm.
authors.affiliation: Department of Pharmaceutical Sciences, Nottingham University, U.K.
authors.forename: M B
authors.initials: MB
authors.lastname: Awang
authors.forename: J G
authors.initials: JG
authors.lastname: Hardy
authors.forename: S S
authors.initials: SS
authors.lastname: Davis
authors.forename: M V
authors.initials: MV
authors.lastname: Pimm
authors.forename: S J
authors.initials: SJ
authors.lastname: Parry
authors.forename: I R
authors.initials: IR
authors.lastname: Wilding
mesh_terms: D000280:Administration, Inhalation; D000284:Administration, Oral; D000818:Animals; D004304:Dosage Forms; D005069:Evaluation Studies as Topic; D005260:Female; D051379:Mice; D008807:Mice, Inbred BALB C; D009502:Neutrons; D004369:Pentetic Acid / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics*; D010599:Pharmacokinetics; D019275:Radiopharmaceuticals / Q000008:administration & dosage / Q000493:pharmacokinetics*; D012493:Samarium; D016284:Technetium Tc 99m Pentetate / Q000008:administration & dosage / Q000493:pharmacokinetics; D014018:Tissue Distribution
chemical_list: D004304:Dosage Forms; D019275:Radiopharmaceuticals; D012493:Samarium; D004369:Pentetic Acid; D016284:Technetium Tc 99m Pentetate