title: Serum concentrations of zinc and copper in bull terriers with lethal acrodermatitis and tail-chasing behavior.
abstract: OBJECTIVE
  To establish similarities or differences in tissue concentrations of zinc, copper, and iron in Bull Terriers with lethal acrodermatitis (LAD) and tail-chasing behavior (TCB) and to confirm the suspicion that copper is involved in the etiopathogenesis of LAD.
  
  
  METHODS
  Serum samples from 29 Bull Terriers (9 control dogs, 6 dogs with LAD, 14 dogs with TCB), and liver and kidney specimens from 2 dogs and 1 and 4 dogs with LAD or TCB, respectively.
  
  
  METHODS
  Serum, liver, and kidney mineral (zinc, copper, and iron) concentrations in Bull Terriers with LAD or TCB and in a group of control dogs were analyzed, using flame atomic absorption after wet ashing technique.
  
  
  RESULTS
  Serum zinc and copper concentrations were lower (P < 0.05) in dogs with LAD, compared with values for control dogs and dogs with TCB. Liver zinc and copper concentrations were similar to serum values. Kidney zinc and copper concentrations were similar among the 3 groups. Serum, liver, and kidney iron concentrations had a wide range of variability within all 3 groups.
  
  
  CONCLUSIONS
  Copper deficiency is associated with LAD. The primary cause of LAD may be copper deficiency, with zinc involved secondarily, or combined zinc and copper deficiencies. The role of ion deficiency in TCB was not clarified.
  
  
  CONCLUSIONS
  Serum zinc and copper concentrations should be determined when LAD is suspected.
authors.affiliation: Department of Surgery, School of Veterinary Medicine, Tufts University, North Grafton, MA 01536, USA.
authors.forename: Y
authors.initials: Y
authors.lastname: Uchida
authors.forename: A A
authors.initials: AA
authors.lastname: Moon-Fanelli
authors.forename: N H
authors.initials: NH
authors.lastname: Dodman
authors.forename: M S
authors.initials: MS
authors.lastname: Clegg
authors.forename: C L
authors.initials: CL
authors.lastname: Keen
mesh_terms: D000169:Acrodermatitis / Q000097:blood / Q000523:psychology / Q000662:veterinary*; D000818:Animals; D003300:Copper / Q000097:blood* / Q000378:metabolism; D004283:Dog Diseases; D004285:Dogs; D005260:Female; D007501:Iron / Q000097:blood / Q000378:metabolism; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D009919:Orchiectomy; D010052:Ovariectomy; D012016:Reference Values; D013239:Stereotyped Behavior; D015032:Zinc / Q000097:blood* / Q000378:metabolism
chemical_list: D003300:Copper; D007501:Iron; D015032:Zinc