title: [Serum levels and in vitro production of IL-5 in children with bronchial asthma].
abstract: IL-5 play important roles in inflammatory responses in bronchial asthma, but little is known about serum levels and in vitro production of IL-5 in childhood bronchial asthma. We further examined serum IL-5 levels in children with bronchial asthma and the controls. IL-5 in serum was detected in all of asthmatic and disease-free individuals. Its values during asthma exacerbation were significantly higher than during remission of asthma. Serum IL-5 values did not significantly differ among groups divided by asthma severity. We studied IL-5 production by peripheral blood mononuclear cells cultured with or without Dermatophagoides farinae (Df) in children with mite allergy. IL-5 concentrations in culture supernatant from after stimulation with Df were significantly higher than those from asthmatic patients without stimulation and from the control subjects. In contrast, IL-5 levels in culture media from the controls were not significantly different between with and without stimulation with Df. Our results suggest that IL-5 may play roles in the pathogenesis of bronchial asthma.
authors.affiliation: Department of Pediatrics, Mizonokuchi Hospital, Teikyo University School of Medicine.
authors.forename: N
authors.initials: N
authors.lastname: Ikeda
authors.forename: A
authors.initials: A
authors.lastname: Ishiguro
authors.forename: K
authors.initials: K
authors.lastname: Uno
authors.forename: Y
authors.initials: Y
authors.lastname: Inaba
authors.forename: T
authors.initials: T
authors.lastname: Ishikita
authors.forename: H
authors.initials: H
authors.lastname: Takahashi
authors.forename: T
authors.initials: T
authors.lastname: Shimbo
mesh_terms: D001249:Asthma / Q000097:blood*; D002648:Child; D006801:Humans; D066298:In Vitro Techniques; D015848:Interleukin-5 / Q000096:biosynthesis / Q000097:blood*; D009000:Monocytes / Q000378:metabolism*
chemical_list: D015848:Interleukin-5