title: The Leu33/Pro polymorphism (PlA1/PlA2) of the glycoprotein IIIa (GPIIIa) receptor is not related to myocardial infarction in the ECTIM Study. Etude Cas-Temoins de l'Infarctus du Myocarde.
abstract: The GPIIb/IIIa receptor complex may contribute to acute coronary syndromes by mediating platelet aggregation. The Leu33/Pro polymorphism (PlA1/PlA2) of the GPIIIa has recently been shown to be associated with CHD in a small case-control study. We have investigated this polymorphism in a large multicenter study of patients with myocardial infarction and controls and found no difference in the distribution of allele and genotype frequencies between cases and controls.
authors.affiliation: Institut National de la Santé et de la Recherche Médicale (Inserm) SC7, Paris, France.
authors.forename: S M
authors.initials: SM
authors.lastname: Herrmann
authors.forename: O
authors.initials: O
authors.lastname: Poirier
authors.forename: P
authors.initials: P
authors.lastname: Marques-Vidal
authors.forename: A
authors.initials: A
authors.lastname: Evans
authors.forename: D
authors.initials: D
authors.lastname: Arveiler
authors.forename: G
authors.initials: G
authors.lastname: Luc
authors.forename: J
authors.initials: J
authors.lastname: Emmerich
authors.forename: F
authors.initials: F
authors.lastname: Cambien
mesh_terms: D000328:Adult; D006801:Humans; D007930:Leucine / Q000235:genetics; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000235:genetics*; D010974:Platelet Aggregation; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic
chemical_list: D019039:Platelet Glycoprotein GPIIb-IIIa Complex; D007930:Leucine