[The expression of Bordetella pertussis protective antigens during bacterial multiplication on a medium with a fixed chemical composition].
The possibility of obtaining native pertussis preparations with high immunobiological activity has been shown. To obtain such preparations, the use of B. pertussis selected strain, its growth under the conditions of static cultivation in a synthetic culture medium and the use of supernatants with the maximum content of protective antigens with the aim of obtaining protective complexes are necessary.
Shmeleva
E I
EI
Mertsalova
N U
NU
Sukhinova
E V
EV
Kirillova
G A
GA
Remova
T N
TN
Bazhanova
I G
IG
Ozeretskovskaia
M N
MN
Britsina
M V
MV
Ermolova
E V
EV
Zakharova
N S
NS
D000818:Animals; D000942:Antigens, Bacterial / Q000096:biosynthesis* / Q000276:immunology / Q000302:isolation & purification; D001431:Bacteriological Techniques; D001886:Bordetella pertussis / Q000254:growth & development / Q000276:immunology*; D003470:Culture Media; D007114:Immunization; D007962:Leukocytes / Q000276:immunology; D051379:Mice; D010567:Pertussis Vaccine / Q000096:biosynthesis* / Q000276:immunology / Q000302:isolation & purification; D010566:Virulence Factors, Bordetella / Q000032:analysis
D000942:Antigens, Bacterial; D003470:Culture Media; D010567:Pertussis Vaccine; D010566:Virulence Factors, Bordetella
Ekspressiia protektivnykh antigenov Bordetella pertussis v protsesse razmnozheniia bakteriĭ v srede opredelennogo khimicheskogo sostava.