title: Neonatal alloimmune thrombocytopenia associated with anti-human platelet antigen-3a antibody.
abstract: A sister and brother with neonatal alloimmune thrombocytopenic purpura (NAITP) caused by maternal anti-human platelet antigen (HPA)-3a are reported. The children had transient severe thrombocytopenia in the newborn period, and were treated with intravenous gamma-globulin and platelet concentrates from random donors. Although the sister had intracranial hemorrhage on day 2 postnatally, the development of the child has been normal and no neurological sequelae have been observed. The brother only had bloody stool when the platelet count was low, and did not have severe hemorrhagic manifestations. The diagnosis of NAITP was made by the sera from the mother, which contained anti-HPA-3a antibody directed against platelets of the children. The rate of recurrence might be high in this family, because the father of the patients was found to be homozygous for the HPA-3a gene.
authors.affiliation: Department of Pediatrics, Miyazaki Prefectural Hospital, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Takada
authors.forename: S
authors.initials: S
authors.lastname: Nakamura
authors.forename: T
authors.initials: T
authors.lastname: Nishiguchi
authors.forename: K
authors.initials: K
authors.lastname: Miyake
authors.forename: K
authors.initials: K
authors.lastname: Hamada
authors.forename: H
authors.initials: H
authors.lastname: Oshikawa
authors.forename: T
authors.initials: T
authors.lastname: Shingu
authors.forename: S
authors.initials: S
authors.lastname: Morita
authors.forename: Y
authors.initials: Y
authors.lastname: Shibata
mesh_terms: D016824:Antigens, Human Platelet / Q000276:immunology*; D002543:Cerebral Hemorrhage / Q000209:etiology; D005838:Genotype; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D007231:Infant, Newborn; D007518:Isoantibodies / Q000276:immunology*; D008297:Male; D010976:Platelet Count; D017713:Platelet Transfusion; D011696:Purpura, Thrombocytopenic / Q000150:complications / Q000235:genetics / Q000276:immunology* / Q000628:therapy
chemical_list: D016824:Antigens, Human Platelet; D016756:Immunoglobulins, Intravenous; D007518:Isoantibodies