Rho proteins: targets for bacterial toxins.
GTP-binding proteins of the Rho family are regulators of the actin cytoskeleton and molecular switches in various signal transduction pathways. The Rho proteins are targets for bacterial protein toxins that either inactivate GTPases by ADP-ribosylation or glucosylation, or activate them by deamidation. Rho proteins play essential roles in host cell invasion by bacteria.
Aktories
K
K
Institut für Pharmakologie and Toxikologie, Albert-Ludwigs-Universität Freiburg, Germany. aktories@ruf.uni-freiburg.de
D000818:Animals; D001427:Bacterial Toxins / Q000494:pharmacology*; D020558:GTP Phosphohydrolases / Q000037:antagonists & inhibitors; D019204:GTP-Binding Proteins / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D015398:Signal Transduction / Q000187:drug effects
D001427:Bacterial Toxins; D020558:GTP Phosphohydrolases; D019204:GTP-Binding Proteins