vesl, a gene encoding VASP/Ena family related protein, is upregulated during seizure, long-term potentiation and synaptogenesis.
We have isolated a novel cDNA, vesl, that was induced during convulsive seizure in the rat hippocampus. The vesl gene encodes a protein of 186 amino acids that has significant homology to the EVH1 domain of the VASP/Ena family of proteins implicated in the control of microfilament dynamics. The expression of vesl mRNA was induced in the granule cell layer during persistent long-term potentiation (LTP) of the dentate gyrus in an NMDA receptor-dependent manner. Furthermore, vesl mRNA was expressed at a high level during hippocampal synaptogenesis. We suggest that the Vesl protein may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development.
Kato
A
A
Mitsubishi Kasei Institute of Life Sciences, Machida, Tokyo, Japan.
Ozawa
F
F
Saitoh
Y
Y
Hirai
K
K
Inokuchi
K
K
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D015152:Blotting, Northern; D002352:Carrier Proteins / Q000235:genetics*; D015815:Cell Adhesion Molecules / Q000235:genetics*; D015870:Gene Expression; D005786:Gene Expression Regulation; D006624:Hippocampus / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism; D000072233:Homer Scaffolding Proteins; D007608:Kainic Acid / Q000494:pharmacology; D017774:Long-Term Potentiation; D008297:Male; D008840:Microfilament Proteins; D008969:Molecular Sequence Data; D009479:Neuropeptides / Q000235:genetics*; D010750:Phosphoproteins / Q000235:genetics*; D012333:RNA, Messenger / Q000032:analysis / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012640:Seizures / Q000378:metabolism*; D013569:Synapses / Q000502:physiology*; D014018:Tissue Distribution; D000098662:Vasodilator-Stimulated Phosphoprotein
D002352:Carrier Proteins; D015815:Cell Adhesion Molecules; D000072233:Homer Scaffolding Proteins; D008840:Microfilament Proteins; D009479:Neuropeptides; D010750:Phosphoproteins; D012333:RNA, Messenger; D000098662:Vasodilator-Stimulated Phosphoprotein; D007608:Kainic Acid