[Clinical, experimental and physiopathological aspects of restenosis after coronary angioplasty].
Restenosis is still the main limitation of coronary angioplasty. A comparison of clinical data and experimental observations from animal models showed the early, local and transient features of this phenomenon. Several hypotheses have been advanced to explain the mechanism. Intimal hyperplasia remains an important feature of restenosis in the human but probably does not play the exclusive role as used to be believed. Vascular remodelling which has several mechanisms seems to be a major contribution to reduction of the vessel lumen. The role of thrombosis remains controversial in the clinical setting but is an essential factor in the pig which is a very similar model to the human. Each of these different mechanisms participates in the development of restenosis but in proportion which remain to be defined.
Brami
M
M
Service d'hémodynamie, Institut de cardiologie de Montréal, Québec, Canada.
Côté
G
G
Bonan
R
R
D015906:Angioplasty, Balloon, Coronary / Q000009:adverse effects; D000818:Animals; D003327:Coronary Disease / Q000503:physiopathology / Q000517:prevention & control / Q000628:therapy*; D003328:Coronary Thrombosis / Q000473:pathology; D003331:Coronary Vessels / Q000293:injuries / Q000473:pathology; D006801:Humans; D011817:Rabbits; D051381:Rats; D012008:Recurrence; D013552:Swine; D017211:Treatment Failure
Aspects cliniques, expérimentaux et physiopathologiques de la resténose après angioplastie coronaire.