The enhancing effect of sodium nitrite on virus-induced leukemia in mice.
A study of the effect of sodium nitrite (SN) on leukemia development in mice induced by Rauscher Leukemia virus (RLV) (Balb/c mice), Mazurenko leukemia virus (MaLV) (CC57Br mice), and Gross leukemia virus (GLV) (AKR/J mice) was performed. SN was administered in water (at concentrations of 5.0, 50.0, 500.0, and 2000.0 mg/l, by NaNO2). A moderate, yet statistically significant acceleration of leukemia development was observed in some groups of SN-treated mice. Our findings and the literature provide evidence that SN has the capacity to enhance the carcinogenic effect of leukemia viruses in vivo.
Ilnitsky
A P
AP
Laboratory of Prevention of Carcinogenic Actions, Cancer Research Center of the Russian Academy of Medical Sciences (RAMS), Moscow, Russia.
Kolpakova
A S
AS
D000818:Animals; D005260:Female; D009052:Leukemia Virus, Murine; D007942:Leukemia, Experimental / Q000821:virology*; D008297:Male; D051379:Mice; D008806:Mice, Inbred AKR; D008807:Mice, Inbred BALB C; D008815:Mice, Inbred Strains; D011925:Rauscher Virus; D012977:Sodium Nitrite; D013953:Thymus Neoplasms / Q000821:virology
D012977:Sodium Nitrite