title: Failure of parturition in mice lacking the prostaglandin F receptor.
abstract: Mice lacking the gene encoding the receptor for prostaglandin F2alpha (FP) developed normally but were unable to deliver normal fetuses at term. Although these FP-deficient mice showed no abnormality in the estrous cycle, ovulation, fertilization, or implantation, they did not respond to exogenous oxytocin because of the lack of induction of oxytocin receptor (a proposed triggering event in parturition), and they did not show the normal decline of serum progesterone concentrations that precedes parturition. Ovariectomy at day 19 of pregnancy restored induction of the oxytocin receptor and permitted successful delivery in the FP-deficient mice. These results indicate that parturition is initiated when prostaglandin F2alpha interacts with FP in ovarian luteal cells of the pregnant mice to induce luteolysis.
authors.affiliation: Department of Physiological Chemistry, Faculty of Pharmaceutical Sciences, Kyoto University, Kyoto 606, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Sugimoto
authors.forename: A
authors.initials: A
authors.lastname: Yamasaki
authors.forename: E
authors.initials: E
authors.lastname: Segi
authors.forename: K
authors.initials: K
authors.lastname: Tsuboi
authors.forename: Y
authors.initials: Y
authors.lastname: Aze
authors.forename: T
authors.initials: T
authors.lastname: Nishimura
authors.forename: H
authors.initials: H
authors.lastname: Oida
authors.forename: N
authors.initials: N
authors.lastname: Yoshida
authors.forename: T
authors.initials: T
authors.lastname: Tanaka
authors.forename: M
authors.initials: M
authors.lastname: Katsuyama
authors.forename: K
authors.initials: K
authors.lastname: Hasumoto
authors.forename: T
authors.initials: T
authors.lastname: Murata
authors.forename: M
authors.initials: M
authors.lastname: Hirata
authors.forename: F
authors.initials: F
authors.lastname: Ushikubi
authors.forename: M
authors.initials: M
authors.lastname: Negishi
authors.forename: A
authors.initials: A
authors.lastname: Ichikawa
authors.forename: S
authors.initials: S
authors.lastname: Narumiya
mesh_terms: D000818:Animals; D003338:Corpus Luteum / Q000378:metabolism*; D015237:Dinoprost / Q000378:metabolism*; D005260:Female; D018390:Gene Targeting; D006579:Heterozygote; D006720:Homozygote; D007743:Labor, Obstetric; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D010052:Ovariectomy; D010121:Oxytocin / Q000096:biosynthesis / Q000494:pharmacology; D011247:Pregnancy; D011374:Progesterone / Q000097:blood; D018045:Receptors, Oxytocin / Q000096:biosynthesis; D011982:Receptors, Prostaglandin / Q000235:genetics / Q000378:metabolism*; D014590:Uterine Contraction / Q000187:drug effects; D014599:Uterus / Q000378:metabolism
chemical_list: D018045:Receptors, Oxytocin; D011982:Receptors, Prostaglandin; C034671:prostaglandin F2alpha receptor; D011374:Progesterone; D010121:Oxytocin; D015237:Dinoprost