title: The effectiveness of topical diclofenac in relieving discomfort following traumatic corneal abrasions.
abstract: Diclofenac is a non-steroidal anti-inflammatory drug available in an ophthalmic preparation. We present a prospective randomised double-masked placebo-controlled trial involving 40 patients that assessed the effectiveness of topical diclofenac in relieving pain from traumatic corneal abrasions. Statistical analysis of visual analogue and categorical pain scores revealed a significant reduction in pain experienced by subjects in the diclofenac group (p < 0.02).
authors.affiliation: Department of Ophthalmology, Newcastle General Hospital, Newcastle upon Tyne, UK.
authors.forename: D G
authors.initials: DG
authors.lastname: Jayamanne
authors.forename: A W
authors.initials: AW
authors.lastname: Fitt
authors.forename: M
authors.initials: M
authors.lastname: Dayan
authors.forename: R M
authors.initials: RM
authors.lastname: Andrews
authors.forename: K W
authors.initials: KW
authors.lastname: Mitchell
authors.forename: P G
authors.initials: PG
authors.lastname: Griffiths
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D065306:Corneal Injuries; D004008:Diclofenac / Q000627:therapeutic use*; D004311:Double-Blind Method; D006801:Humans; D008875:Middle Aged; D010146:Pain / Q000188:drug therapy* / Q000209:etiology; D010147:Pain Measurement; D011446:Prospective Studies
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004008:Diclofenac