title: A computer program for constructing multivariate reference models.
abstract: From a statistical point of view the simultaneous interpretation of multiple variables should be performed with a multivariate reference model rather than with multiple univariate reference intervals. A computer program for constructing and testing multivariate reference models is described. The use of the computer program is illustrated with a data set of total serum calcium concentrations and serum albumin concentrations from 222 2nd year medical students. Using a single univariate reference interval for total serum calcium, 17 students were classified as having an abnormal calcemic status while using a bivariate reference model for total serum calcium and serum albumin, 13 of these 17 students had in fact normal total serum calcium concentrations, taking into account their serum albumin concentrations.
authors.affiliation: Department of Medical Informatics, Erasmus University, Rotterdam, Netherlands. hekking@mi.fgg.eur.nl
authors.forename: M
authors.initials: M
authors.lastname: Hekking
authors.forename: J
authors.initials: J
authors.lastname: Lindemans
authors.forename: E S
authors.initials: ES
authors.lastname: Gelsema
mesh_terms: D001699:Biometry; D002118:Calcium / Q000097:blood; D006801:Humans; D008954:Models, Biological; D015233:Models, Statistical; D015999:Multivariate Analysis; D012016:Reference Values; D012709:Serum Albumin / Q000378:metabolism; D012984:Software
chemical_list: D012709:Serum Albumin; D002118:Calcium