[The effect of polyunsaturated fatty acids on the biochemical indices of bronchial asthma patients].
A placebo-controlled study was made of the efficacy of diet additive of omega-3 polyunsaturated fatty acids (diet oil eiconol) in 27 patients with bronchial asthma (BA). It was found that eiconol causes qualitative changes in the disease course: severe attacks of asphyxia occurred less frequently, drug doses were reduced. Provocative tests with allergen after two-week intake of eiconol versus placebo intake showed a significant decline of late allergic response due to compitative replacement of arachidonic acid in cell membranes of inflammation cell effectors by omega-3 polyunsaturated fatty acids inhibiting production of lipid mediators of inflammation.
Masuev
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KA
D018927:Anti-Asthmatic Agents / Q000627:therapeutic use*; D001249:Asthma / Q000097:blood / Q000188:drug therapy*; D004042:Dietary Fats, Unsaturated / Q000627:therapeutic use*; D004311:Double-Blind Method; D004341:Drug Evaluation; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism; D005260:Female; D005395:Fish Oils / Q000627:therapeutic use*; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D013997:Time Factors
D018927:Anti-Asthmatic Agents; D004042:Dietary Fats, Unsaturated; D005395:Fish Oils; C089938:eiconol
Vliianie polinenasyshchennykh kislot na nekotorye biokhimicheskie pokazateli u bol'nykh bronkhial'noĭ astmoĭ.