title: Blood pressure lowering for the prevention of cognitive decline in patients with cerebrovascular disease. PROGRESS Management Committee. Perindopril Protection Against Recurrent Stroke Study.
abstract: Cerebrovascular disease and high blood pressure both appear to increase the risk of vascular dementia. PROGRESS aims to investigate whether blood pressure lowering with an angiotensin coverting enzyme inhibitor-based regimen will reduce the risk of cognitive impairment in patients with a history of stroke or transient ischaemic attack. A total of at least 6000 patients will be randomised to receive perindopril (+/- indapamide) or matching placebo(s), with treatment and follow-up scheduled to continue for at least 4 years. Substudies will investigate the effects of treatment on cognitive decline in subgroups defined by apo-E genotype and on white matter lesions assessed by magnetic resonance imaging. Final results from the study should be available in 2001.
authors.affiliation: Department of Medicine, University of Auckland, New Zealand.
authors.forename: G
authors.initials: G
authors.lastname: Whitlock
authors.forename: S
authors.initials: S
authors.lastname: MacMahon
authors.forename: C
authors.initials: C
authors.lastname: Anderson
authors.forename: B
authors.initials: B
authors.lastname: Neal
authors.forename: A
authors.initials: A
authors.lastname: Rodgers
authors.forename: J
authors.initials: J
authors.lastname: Chalmers
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology*; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects*; D002561:Cerebrovascular Disorders / Q000188:drug therapy* / Q000503:physiopathology / Q000523:psychology; D002985:Clinical Protocols; D015140:Dementia, Vascular / Q000503:physiopathology / Q000517:prevention & control*; D004232:Diuretics / Q000494:pharmacology; D005260:Female; D006801:Humans; D007190:Indapamide / Q000494:pharmacology; D007211:Indoles / Q000494:pharmacology*; D002546:Ischemic Attack, Transient / Q000188:drug therapy / Q000503:physiopathology / Q000523:psychology; D008297:Male; D008875:Middle Aged; D020913:Perindopril
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D004232:Diuretics; D007211:Indoles; D007190:Indapamide; D020913:Perindopril