Characterization of a periplasmic protein involved in iron utilization of Actinobacillus actinomycetemcomitans.
The periodontopathic bacterium Actinobacillus actinomycetemcomitans possesses a 35-kDa periplasmic iron-repressible protein. Its regulation is mediated by the Fur protein, as was inferred from the Fur-binding consensus sequence at the -35 position of the gene for the 35-kDa protein and from the relaxed expression of the gene in a mutant with an altered Fur-binding sequence. The 35-kDa protein, designated AfuA, has strong homology to HitA and FbpA of Haemophilus influenzae and Neisseria meningitidis, respectively, which serve as periplasmic iron transport proteins.
Willemsen
P T
PT
Department of Oral Microbiology, Academic Centre for Dentistry Amsterdam, The Netherlands. PTJ.Willemsen.omb.acta@med.vu.nl
Vulto
I
I
Boxem
M
M
de Graaff
J
J
D016976:Aggregatibacter actinomycetemcomitans; D000595:Amino Acid Sequence; D001425:Bacterial Outer Membrane Proteins; D001426:Bacterial Proteins / Q000235:genetics* / Q000378:metabolism; D001483:Base Sequence; D002352:Carrier Proteins / Q000235:genetics* / Q000378:metabolism; D003593:Cytoplasm / Q000378:metabolism; D004269:DNA, Bacterial; D007501:Iron / Q000378:metabolism*; D033862:Iron-Binding Proteins; D008969:Molecular Sequence Data; D033902:Periplasmic Binding Proteins; D012097:Repressor Proteins / Q000378:metabolism; D017386:Sequence Homology, Amino Acid
D001425:Bacterial Outer Membrane Proteins; D001426:Bacterial Proteins; D002352:Carrier Proteins; D004269:DNA, Bacterial; D033862:Iron-Binding Proteins; D033902:Periplasmic Binding Proteins; D012097:Repressor Proteins; C068477:ferric uptake regulating proteins, bacterial; D007501:Iron