Gains in bone mineral density with resolution of vitamin D intoxication.
BACKGROUND
Vitamin D intoxication is associated with the mobilization of skeletal calcium.


OBJECTIVE
To ascertain how the resolution of vitamin D intoxication affects bone density.


METHODS
Case series.


METHODS
Referral service for metabolic bone disease in a tertiary care teaching hospital.


METHODS
Four patients with osteoporosis who were each using several nonprescription dietary supplements and were found to have fasting hypercalciuria.


METHODS
Discontinuation of use of dietary supplements.


METHODS
Serial measurement of serum levels of 25-hydroxyvitamin D, ratio of fasting urinary calcium to creatinine, and bone mineral density for 3 years.


RESULTS
Discontinuation of use of dietary supplements resulted in the normalization of serum levels of 25-hydroxyvitamin D, the normalization of the ratio of urinary calcium to creatinine, and a mean annual increase in bone mineral density (+/- SD) of 1.9% +/- 0.5%.


CONCLUSIONS
Occult vitamin D intoxication was detected in patients who were using dietary supplements that contained an unadvertised high level of vitamin D. Resolution of vitamin D intoxication was associated with a rebound in bone mineral density.
Adams
J S
JS
Cedars-Sinal Medical Center, Los Angeles, California, USA.
Lee
G
G
D000328:Adult; D000368:Aged; D015519:Bone Density / Q000187:drug effects*; D002118:Calcium / Q000652:urine; D003404:Creatinine / Q000652:urine; D005260:Female; D005527:Food, Fortified / Q000506:poisoning*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis / Q000139:chemically induced* / Q000378:metabolism; D014807:Vitamin D / Q000031:analogs & derivatives / Q000097:blood / Q000506:poisoning*
D014807:Vitamin D; C104450:25-hydroxyvitamin D; D003404:Creatinine; D002118:Calcium