[The role of Porphyromonas gingivalis proteinases in periodontitis].
Periodontitis, an inflammation of periodontal tissues, exists in several clinical forms. The most common one is adult periodontitis with Porphyromonas gingivalis, a Gram-negative anaerobic rod, being generally regarded as the major pathogen involved in this disease. This organism produces a large quantity of proteolytic enzymes, as virulence factors, which are considered to play a crucial role in its pathogenecity. These enzymes are involved in both destruction of periodontal tissues and interrupting host-defence mechanisms through the degradation of immunoglobulins and complement factors leading eventually to disease progression.
Polanowska
J
J
Instytut Biochemii i Biologii Molekularnej, Uniwersytetu Wrocławskiego.
Polanowski
A
A
D000328:Adult; D001422:Bacterial Adhesion; D016866:Bacteroidaceae Infections / Q000382:microbiology*; D018450:Disease Progression; D006801:Humans; D010447:Peptide Hydrolases / Q000378:metabolism*; D010518:Periodontitis / Q000382:microbiology*; D016966:Porphyromonas gingivalis / Q000201:enzymology* / Q000472:pathogenicity
D010447:Peptide Hydrolases
Udział proteinaz Porphyromonas gingivalis w patogenezie chorób przyzebia.