Products from mast cells influence T lymphocyte proliferation and cytokine production--relevant to allergic asthma?
In IgE allergic diseases both mast cells and T lymphocytes play an important role. Whereas mast cels have been implicated in immediate allergic responses, T lymphocytes mediate subsequent late phase responses and chronic inflammation. Here we review possible links between the early mast cell activation and the later T lymphocyte stimulation. Products from mast cells were found to exert effects on T lymphocytes. Human Mast Cell line-1 (HMC-1) mast cells modulated proliferation and cytokine production of a human CD8+ T-cell clone in vitro. Activated mast cells seemed to drive this CD8+ T-cell clone towards a more pronounced T (helper) 1 type of response, simultaneously decreasing T-cell numbers. It is hypothesized that this might be a negative feed back mechanism operating in allergic subjects, by which the Th2-driven IgE production and eosinophilia are counteracted.
de Pater-Huijsen
F L
FL
Clinical and Laboratory Immunology Unit, Academic Medical Center, Amsterdam, Netherland.
Pompen
M
M
Jansen
H M
HM
Out
T A
TA
D000818:Animals; D001249:Asthma / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000166:cytology / Q000276:immunology*; D002455:Cell Division; D002460:Cell Line; D016207:Cytokines / Q000096:biosynthesis*; D006801:Humans; D008407:Mast Cells / Q000166:cytology / Q000276:immunology*
D016207:Cytokines