title: True histiocytic lymphoma as a second neoplasm in a follicular centroblastic-centrocytic lymphoma.
abstract: We report on a patient who developed a true histiocytic lymphoma, 16 years after initial diagnosis of a follicular low grade centroblastic-centrocytic lymphoma with several recurrences. We consider, out of gene rearrangement and immunohistochemical studies, that in this case, true histiocytic lymphoma is a second neoplasm in the evolutive course of the low grade lymphoma. The natural history of a low grade malignant lymphoma is to develop into a high grade large cell lymphoma and, if a second neoplasm appears, it is usually an epithelial tumor. This fact makes our report unique, as it would be, to our knowledge, the first case of true histiocytic lymphoma as the second neoplasm of another lymphoma.
authors.affiliation: Department of Surgical Pathology, Hospital Clinico Universitario San Carlos, Madrid, Spain.
authors.forename: C
authors.initials: C
authors.lastname: Martin Rodilla
authors.forename: J
authors.initials: J
authors.lastname: Fernández Aceñero
authors.forename: L
authors.initials: L
authors.lastname: Peña Mayor
authors.forename: A
authors.initials: A
authors.lastname: Alvarez Carmona
mesh_terms: D015703:Antigens, CD / Q000032:analysis; D015214:Antigens, Differentiation, Myelomonocytic / Q000032:analysis; D017809:Fatal Outcome; D006801:Humans; D007150:Immunohistochemistry; D008198:Lymph Nodes / Q000473:pathology; D008224:Lymphoma, Follicular / Q000276:immunology / Q000473:pathology*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000276:immunology / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000276:immunology / Q000473:pathology*; D013363:Submandibular Gland; D000097382:CD68 Molecule
chemical_list: D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; C067980:CD68 antigen, human; D000097382:CD68 Molecule