Nucleotide sequence of equine MxA cDNA.
A 2.6 kb cDNA species has been isolated from a cDNA library prepared from interferon-alpha stimulated equine peripheral blood leucocytes and the nucleotide sequence determined. The cDNA has a single open reading frame potentially encoding a 660 amino acid polypeptide showing a high degree of homology with known mammalian Mx proteins, including the possession of three consensus GTP-binding motifs. The protein has a calculated pI = 6.1 and in accordance with proposed nomenclature we have designated it equine MxA.
Chesters
P M
PM
Department of Pathology and Infectious Diseases, The Royal Veterinary College, London, UK.
Steele
M
M
Purewal
A
A
Edington
N
N
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D019204:GTP-Binding Proteins; D006736:Horses; D008969:Molecular Sequence Data; D064547:Myxovirus Resistance Proteins; D014176:Protein Biosynthesis; D011506:Proteins / Q000235:genetics* / Q000378:metabolism; D017422:Sequence Analysis, DNA
D064547:Myxovirus Resistance Proteins; D011506:Proteins; D019204:GTP-Binding Proteins