Comparative in vitro activities of carbapenem L-749,345 and other antimicrobials against multiresistant gram-negative clinical pathogens.
Carbapenems L-749,345 and imipenem had the lowest MICs at which 90% of isolates were inhibited (0.5 microg/ml) of 14 antimicrobial agents tested against 76 multiresistant gram-negative clinical isolates with TEM- or SHV-type extended-spectrum beta-lactamases and chromosomal or plasmid-determined AmpC beta-lactamases, but the MIC of L-749,345 for one isolate of Klebsiella pneumoniae was 16 microg/ml.
Jacoby
G
G
Lahey Hitchcock Clinic, Burlington, Massachusetts 01805, USA. George.A.Jacoby@Lahey.Hitchcock.Org
Han
P
P
Tran
J
J
D015780:Carbapenems / Q000494:pharmacology*; D018432:Drug Resistance, Multiple; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D018440:beta-Lactam Resistance
D015780:Carbapenems; C108047:L 749345