title: Oleanolic acid and ursolic acid stabilize liposomal membranes.
abstract: The effects of oleanolic acid (OA) and ursolic acid (UA) on the fluidity and stability of dipalmitoyl phosphatidylcholine (DPPC) liposomal membrane were monitored by measuring the fluorescence polarization of 1,6-diphenyl-1,3,5-hexatriene labeled in the liposomal membrane and the leakage of calcein from the probe-encapsulated liposomes. The experiments with the liposomes made of DPPC and OA or UA showed that OA and UA exhibited a moderate fluidity-modulating effect for the liquid-crystalline liposomal membrane, and a strong condensing effect for both crystalline and liquid-crystalline liposomal membranes. Their effects were comparable to those of cholesterol. These results suggest that their fluidity-modulating and condensing effects might have some implications in their biological functions.
authors.affiliation: College of Pharmacy, Pusan National University, Republic of Korea. Hansk@hyowon.pusan.ac.kr
authors.forename: S K
authors.initials: SK
authors.lastname: Han
authors.forename: Y I
authors.initials: YI
authors.lastname: Ko
authors.forename: S J
authors.initials: SJ
authors.lastname: Park
authors.forename: I J
authors.initials: IJ
authors.lastname: Jin
authors.forename: Y M
authors.initials: YM
authors.lastname: Kim
mesh_terms: D004161:Diphenylhexatriene; D005452:Fluoresceins / Q000378:metabolism; D005454:Fluorescence Polarization; D006358:Hot Temperature; D008081:Liposomes; D008560:Membrane Fluidity / Q000187:drug effects*; D009828:Oleanolic Acid / Q000494:pharmacology*; D010539:Permeability / Q000187:drug effects; D014315:Triterpenes / Q000494:pharmacology*; D000097245:Ursolic Acid
chemical_list: D004161:Diphenylhexatriene; D005452:Fluoresceins; D008081:Liposomes; D009828:Oleanolic Acid; D014315:Triterpenes; D000097245:Ursolic Acid; C007740:fluorexon