title: Intradiscal glycerol or bupivacaine in the treatment of low back pain.
abstract: A total of 15 patients suffering from chronic low back pain were treated with an intradiscal injection of either 1 ml of 50% glycerol or 2 ml of 0.5% bupivacaine. Most (60%) of the patients had previously undergone spinal surgery for lumbar disc herniation or spinal stenosis and 73% showed clinical signs and symptoms of segmental instability of the lumbar spine. According to self-evaluation questionnaires, immediate response to both treatments was mainly good. Of the 9 patients who received glycerol, 56% showed subjective improvement on the first day after the injection and after two weeks, 45% of the patients still felt improvement. After one month, however, the pain had reappeared in all except one (11%) patient. The corresponding numbers for the 6 with bupivacaine treated patients were 83%, 67%, and 17%. Based on the very short duration of response to the treatment, we did not find intradiscal injections with these agents to be cost-effective. In our department, this therapeutic approach is no longer employed in patients with chronic discogenic pain.
authors.affiliation: Department of Neurosurgery, University of Turku, Finland.
authors.forename: E
authors.initials: E
authors.lastname: Kotilainen
authors.forename: P
authors.initials: P
authors.lastname: Muittari
authors.forename: O
authors.initials: O
authors.lastname: Kirvelä
mesh_terms: D000328:Adult; D000779:Anesthetics, Local / Q000627:therapeutic use*; D002045:Bupivacaine / Q000627:therapeutic use*; D002908:Chronic Disease / Q000188:drug therapy; D003451:Cryoprotective Agents / Q000627:therapeutic use*; D005260:Female; D005990:Glycerol / Q000627:therapeutic use*; D006801:Humans; D007405:Intervertebral Disc Displacement / Q000188:drug therapy*; D017116:Low Back Pain / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged
chemical_list: D000779:Anesthetics, Local; D003451:Cryoprotective Agents; D005990:Glycerol; D002045:Bupivacaine