Localised oral histoplasmosis lesions associated with HIV infection.
Opportunistic fungal infections account for a significant amount of morbidity associated with HIV disease. We report here a case of localised oral histoplasmosis without evidence of disseminated disease in a patient who lacked stigmata of HIV disease at the time of initial presentation. The diagnosis is based on histology with special stains, complement fixing antibodies in serum, and culture of the organism from fresh tissues. Activation of subclinical disease following an infection in Uganda may explain the development of these exophytic oral lesions in this British resident.
Warnakulasuriya
K A
KA
RCS Department of Dental Sciences/WHO Collaborating Centre for Oral Cancer and Precancer, King's College School of Medicine and Dentistry, London, England.
Harrison
J D
JD
Johnson
N W
NW
Edwards
S
S
Taylor
C
C
Pozniak
A L
AL
D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy / Q000473:pathology*; D000328:Adult; D000908:Antibodies, Fungal / Q000097:blood; D000935:Antifungal Agents / Q000627:therapeutic use; D004396:Coloring Agents; D003165:Complement System Proteins / Q000032:analysis; D003937:Diagnosis, Differential; D005260:Female; D005882:Gingival Diseases / Q000188:drug therapy / Q000382:microbiology* / Q000473:pathology; D006679:HIV Seropositivity / Q000382:microbiology; D006658:Histoplasma / Q000145:classification / Q000302:isolation & purification; D006660:Histoplasmosis / Q000188:drug therapy / Q000473:pathology*; D006801:Humans; D017964:Itraconazole / Q000627:therapeutic use; D014454:Uganda / Q000208:ethnology; D006113:United Kingdom
D000908:Antibodies, Fungal; D000935:Antifungal Agents; D004396:Coloring Agents; D017964:Itraconazole; D003165:Complement System Proteins