title: Transrectal ultrasound guided manipulation of the canine prostate with minimum intervention.
abstract: The canine prostate is a widely used and well established animal model for the assessment of therapeutic effects of laser technology in the search for better options for the treatment of benign prostatic hyperplasia. Conventionally for such experiments, the canine prostate is approached by laparotomy or transperineal urethrotomy. We have demonstrated a technique involving the use of ultrasound guided biopsy of the liver and prostate, and percutaneous laser treatment of the prostate, which has proved to be effective in reducing adverse effects on the experimental animals but without compromising scientific requirements for the experiments. We conclude that state-of-the-art percutaneous procedures not only refine animal intervention significantly but are also technically feasible for most laser studies using the canine prostate as an experimental model in the live animal.
authors.affiliation: National Medical Laser Centre, Department of Surgery, London, UK.
authors.forename: S C
authors.initials: SC
authors.lastname: Chang
authors.forename: S
authors.initials: S
authors.lastname: Anthony
authors.forename: P C
authors.initials: PC
authors.lastname: Koder
authors.forename: S G
authors.initials: SG
authors.lastname: Brown
mesh_terms: D000818:Animals; D001707:Biopsy, Needle / Q000662:veterinary; D004195:Disease Models, Animal; D004285:Dogs; D053685:Laser Therapy / Q000662:veterinary; D008099:Liver / Q000000981:diagnostic imaging / Q000473:pathology; D008297:Male; D011467:Prostate / Q000000981:diagnostic imaging / Q000601:surgery*; D011470:Prostatic Hyperplasia / Q000601:surgery*; D012007:Rectum; D018084:Ultrasonography, Interventional / Q000379:methods / Q000662:veterinary*