title: Cerebral glucose utilization is reduced in second test session.
abstract: Cerebral glucose utilization was higher during the first positron emission tomography (PET) session than during the second session, as assayed using the PET [18F]fluorodeoxyglucose method in male human volunteers. This difference was due largely to data from subjects with low-trait anxiety, since subjects with high anxiety showed similar metabolism in both PET sessions. High-anxiety subjects showed greater right/ left ratios of cerebral metabolism than low-anxiety subjects, particularly during the second PET session. These findings suggest that the level of anxiety may be an important variable to consider in PET studies using multiple sessions.
authors.affiliation: Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland, USA.
authors.forename: J M
authors.initials: JM
authors.lastname: Stapleton
authors.forename: M J
authors.initials: MJ
authors.lastname: Morgan
authors.forename: X
authors.initials: X
authors.lastname: Liu
authors.forename: B C
authors.initials: BC
authors.lastname: Yung
authors.forename: R L
authors.initials: RL
authors.lastname: Phillips
authors.forename: D F
authors.initials: DF
authors.lastname: Wong
authors.forename: E K
authors.initials: EK
authors.lastname: Shaya
authors.forename: R F
authors.initials: RF
authors.lastname: Dannals
authors.forename: E D
authors.initials: ED
authors.lastname: London
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001007:Anxiety / Q000378:metabolism*; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism*; D005625:Frontal Lobe / Q000378:metabolism; D007839:Functional Laterality; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D008297:Male; D012016:Reference Values; D013702:Temporal Lobe / Q000378:metabolism; D013788:Thalamus / Q000378:metabolism; D014055:Tomography, Emission-Computed
chemical_list: D005947:Glucose