A Tourette-like syndrome following cardiopulmonary bypass and hypothermia: MRI volumetric measurements.
We present the case of an adolescent boy who developed a variety of simple and complex motor and vocal tics (Tourette-like syndrome), along with inattentiveness and obsessive-compulsive behaviors after cardiac surgery with cardiopulmonary bypass and profound hypothermia. A single photon emission computed tomography study 2 months after surgery showed reduced uptake in the left hemisphere and 2 years later a perfusion defect in the basal ganglia. Serial magnetic resonance imaging (MRI) studies were normal. Volumetric MRI studies were obtained 4 years after surgery and compared with published values for normal individuals and children with Tourette syndrome (TS), including subsets matched for age, sex, and handedness. Measurement of basal ganglia structures showed a right-dominant asymmetry of the caudate and putamen, in part similar to findings previously reported in patients with TS. Other volumetric abnormalities included a > 2-SD reduction of cortical gray matter, a small decrease of total cerebral volume, and increase in cerebral white matter. Although a variety of neurological problems may occur after cardiopulmonary bypass, to our knowledge this case represents the first report of a chronic tic disorder following cardiac surgery with cardiopulmonary bypass and hypothermia.
Singer
H S
HS
Department of Neurology, Johns Hopkins Hospital, Baltimore, MD 21287-8811, USA.
Dela Cruz
P S
PS
Abrams
M T
MT
Bean
S C
SC
Reiss
A L
AL
D001289:Attention Deficit Disorder with Hyperactivity / Q000209:etiology; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology; D002315:Cardiopulmonary Bypass / Q000009:adverse effects*; D002648:Child; D006801:Humans; D007036:Hypothermia, Induced / Q000009:adverse effects*; D008279:Magnetic Resonance Imaging; D008297:Male; D009771:Obsessive-Compulsive Disorder / Q000209:etiology; D015899:Tomography, Emission-Computed, Single-Photon; D005879:Tourette Syndrome / Q000000981:diagnostic imaging / Q000209:etiology* / Q000503:physiopathology