title: [A clinical and experimental validation of the use of Stimuloss in patients with chronic generalized periodontitis].
abstract: The pharmacological effect of hydroxyapatite and a composition based on it in the form of Stimulos sponge has been studied in human osteogenic tissue culture. Hydroxyapatite stimulated the biosynthetic processes in the cells. Addition of chlorohexidine and thymogen to the composition in order to increase its antibacterial activity did not decrease the osteoinductive properties of the drug. Trials of Stimulos in 66 patients with chronic generalized periodontitis demonstrated its high efficacy, particularly of the compositions containing immunostimulants: inflammation disappeared and the height of alveolar osseous tissue increased, as did bone compactness.
authors.forename: T D
authors.initials: TD
authors.lastname: Fedosenko
authors.forename: L G
authors.initials: LG
authors.lastname: Vladimirova
authors.forename: I N
authors.initials: IN
authors.lastname: Ivasenko
mesh_terms: D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000328:Adult; D000539:Alveolar Process / Q000187:drug effects; D000818:Animals; D000891:Anti-Infective Agents, Local / Q000627:therapeutic use*; D001672:Biocompatible Materials / Q000627:therapeutic use*; D002710:Chlorhexidine / Q000627:therapeutic use*; D002908:Chronic Disease; D003094:Collagen / Q000627:therapeutic use*; D046508:Culture Techniques; D004151:Dipeptides; D004338:Drug Combinations; D004341:Drug Evaluation; D004353:Drug Evaluation, Preclinical; D017886:Durapatite / Q000627:therapeutic use*; D005260:Female; D005333:Fetus; D006801:Humans; D008297:Male; D008875:Middle Aged; D010012:Osteogenesis / Q000187:drug effects; D010455:Peptides / Q000627:therapeutic use*; D010518:Periodontitis / Q000188:drug therapy*; D013552:Swine
chemical_list: D000276:Adjuvants, Immunologic; D000891:Anti-Infective Agents, Local; D001672:Biocompatible Materials; D004151:Dipeptides; D004338:Drug Combinations; D010455:Peptides; C060736:thymogen; D003094:Collagen; D017886:Durapatite; D002710:Chlorhexidine
vernacular_title: Kliniko-éksperimental'noe obosnovanie primeneniia u bol'nykh khronicheskim parodontitom "Stimulossa".