Chicken NKx2-8, a novel homeobox gene expressed during early heart and foregut development.
cNkx2-8 represents a novel member of the NK2-family transcription factors. The gene contains three highly conserved regions, the TN-, NK2-, and homeodomains which are diagnostic for this group of proteins. cNkx2-8 is expressed during chick embryogenesis in ventral foregut endoderm, myocardial mesoderm, epithelium of the branchial arches and the dorsal mesocardium. While cNkx2-8 expression partially overlaps with other NK genes, such as Nkx2-5 and Nkx2-3, its onset and aspects of its expression domains are specific. Thus, structural data and the expression profile suggest that cNkx2-8 constitutes a new homeobox protein which may cooperate with its known relatives in defining an antero-ventral field including the developing heart and pharyngeal endoderm.
Brand
T
T
Department of Cell and Molecular Biology, University of Braunschweig, Germany.
Andrée
B
B
Schneider
A
A
Buchberger
A
A
Arnold
H H
HH
D000818:Animals; D002642:Chick Embryo; D003001:Cloning, Molecular; D017931:DNA Primers / Q000235:genetics; D004064:Digestive System / Q000196:embryology*; D018507:Gene Expression Regulation, Developmental; D005801:Genes, Homeobox; D006321:Heart / Q000196:embryology*; D018398:Homeodomain Proteins / Q000235:genetics*; D017403:In Situ Hybridization; D005810:Multigene Family; D016133:Polymerase Chain Reaction; D017386:Sequence Homology, Amino Acid; D014157:Transcription Factors / Q000235:genetics*
D017931:DNA Primers; D018398:Homeodomain Proteins; C108070:NKX2-8 protein, human; D014157:Transcription Factors