Long gonadotrophin releasing hormone agonist/human menopausal gonadotrophin protocol for ovarian stimulation in intrauterine insemination treatment.
OBJECTIVE
This prospective study was undertaken to examine the usefulness of a long gonadotrophin releasing hormone agonist (GnRH-a)/human menopausal gonadotrophin (hMG) protocol in intrauterine insemination (IUI) treatment. The results were compared to those of clomiphene citrate (CC)/hMG/IUI.


METHODS
Seventy-five patients were recruited to a GnRH-a/hMG group (group 1) while 88 patients underwent CC/hMG stimulation and served as controls (group 2). The study subjects were stimulated with a long GnRH-a/hMG regimen. IUI was performed 36 h after the administration of human chorionic gonadotrophin.


RESULTS
The number of preovulatory follicles, the thickness of endometrium and sperm parameters were similar in both groups. The hMG requirements were significantly higher in group 1 than in group 2 (21.2 +/- 5.1 vs. 8.1 +/- 3.1 ampoules). The pregnancy rate was 20% in group 1 and 12.5% in group 2, the difference being not significant.


CONCLUSIONS
The pregnancy rates were not significantly different between the GnRH-a/hMG/ IUI and CC/hMG/IUI groups. In addition, GnRH-a/hMG stimulation is notably more expensive than CC/hMG, and for these reasons, GnRH-a/hMG stimulation is not cost-effective in routine IUI therapy.
Nuojua-Huttunen
S
S
Department of Obstetrics and Gynecology, University of Oulu, Finland.
Tuomivaara
L
L
Juntunen
K
K
Tomás
C
C
Martikainen
H
H
D000328:Adult; D002064:Buserelin / Q000008:administration & dosage* / Q000627:therapeutic use; D002996:Clomiphene / Q000008:administration & dosage; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007246:Infertility / Q000628:therapy; D007317:Insemination, Artificial, Homologous; D008297:Male; D008596:Menotropins / Q000008:administration & dosage* / Q000627:therapeutic use; D010062:Ovulation Induction; D011247:Pregnancy; D011272:Pregnancy, Multiple; D011446:Prospective Studies
D002996:Clomiphene; D008596:Menotropins; D002064:Buserelin