1H-magnetic resonance spectroscopy in obsessive-compulsive disorder: evidence for neuronal loss in the cingulate gyrus and the right striatum.
We compared 12 patients with obsessive-compulsive disorder (OCD) and six control subjects by 1H-magnetic resonance spectroscopy. Significantly lower relative N-acetyl-aspartate (NAA) levels were found in the right striatum of OCD patients, as well as a decrease of anterior cingulate NAA that correlated with severity of illness. Age and sex were correlated to striatal NAA levels.
Ebert
D
D
Department of Psychiatry, University of Freiburg, Germany.
Speck
O
O
König
A
A
Berger
M
M
Hennig
J
J
Hohagen
F
F
D000328:Adult; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000032:analysis; D002452:Cell Count; D003342:Corpus Striatum / Q000033:anatomy & histology* / Q000737:chemistry / Q000166:cytology; D005260:Female; D007839:Functional Laterality; D006179:Gyrus Cinguli / Q000033:anatomy & histology* / Q000737:chemistry / Q000166:cytology; D006801:Humans; D006859:Hydrogen; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D009771:Obsessive-Compulsive Disorder / Q000175:diagnosis* / Q000378:metabolism; D010296:Parietal Lobe / Q000033:anatomy & histology / Q000737:chemistry / Q000166:cytology; D012720:Severity of Illness Index
D001224:Aspartic Acid; D006859:Hydrogen; C000179:N-acetylaspartate