Cardiopulmonary compromise after use of topical and submucosal alpha-agonists: possible added complication by the use of beta-blocker therapy.
We report the specifics of 12 cases of severe hypertension after the intraoperative use of topical phenylephrine, submucosal epinephrine, or both. Ten of these 12 patients also developed severe pulmonary edema. Seven of the twelve were treated with beta blockers; 3 of whom suffered cardiac arrest. We propose a common mechanism: the vasoconstrictors caused systemic hypertension, increased left ventricular afterload, decreased left ventricular compliance, and decreased cardiac output. In those patients treated with beta blockers, decreased contractility and inability to increase heart rate further compromised cardiopulmonary function.
Kalyanaraman
M
M
Department of Pediatrics and Human Development, Michigan State University, East Lansing, USA.
Carpenter
R L
RL
McGlew
M J
MJ
Guertin
S R
SR
D000281:Administration, Intranasal; D000316:Adrenergic alpha-Agonists / Q000009:adverse effects*; D000319:Adrenergic beta-Antagonists / Q000009:adverse effects*; D002648:Child; D004837:Epinephrine / Q000009:adverse effects; D005260:Female; D006323:Heart Arrest / Q000139:chemically induced; D006801:Humans; D006973:Hypertension / Q000139:chemically induced* / Q000188:drug therapy; D007431:Intraoperative Complications / Q000139:chemically induced* / Q000188:drug therapy; D007442:Intubation, Intratracheal; D007741:Labetalol / Q000009:adverse effects; D008297:Male; D010656:Phenylephrine / Q000009:adverse effects; D011412:Propanolamines / Q000009:adverse effects; D011654:Pulmonary Edema / Q000139:chemically induced
D000316:Adrenergic alpha-Agonists; D000319:Adrenergic beta-Antagonists; D011412:Propanolamines; D010656:Phenylephrine; C036604:esmolol; D007741:Labetalol; D004837:Epinephrine