title: [Effect of domestication of the silver fox on the main enzymes of serotonin metabolism and serotonin receptors].
abstract: In silver foxes significant alterations in the activities of basic enzymes of neurotransmitter serotonin metabolism as well as in the densities of receptors caused by selection for the absence of the aggressive defensive reaction to man were demonstrated. In the midbrain and hypothalamus of animals selected for the absence of aggressive behavior, the activity of tryptophan hydroxylase, the key enzyme of serotonin biosynthesis, was found to be remarkably higher than in animals selected for highly aggressive behavior. Domesticated animals were characterized by low activity of the main enzyme of serotonin catabolism, monoamine oxidase type A, increased Michaelis constant km, and an unchanged maximum reaction rate (Vmax). No changes in the specific binding of [3H]-ketanserin and [3H]-8-OH-DPAT in the frontal cortex of domesticated foxes were revealed; however, in the hypothalamus, the low values of Bmax for the [3H]-8-OH-DPAT specific binding were observed, indicating the decreased density of the 5-HT1A receptors. It is assumed that the transformation of a wild aggressive animal into a domesticated one taking place during directional selection is caused by hereditary alterations favored by artificial selection in the activity of the main enzymes of serotonin metabolism and serotonin receptors.
authors.forename: N K
authors.initials: NK
authors.lastname: Popova
authors.forename: A V
authors.initials: AV
authors.lastname: Kulikov
authors.forename: D F
authors.initials: DF
authors.lastname: Avgustinovich
authors.forename: N N
authors.initials: NN
authors.lastname: Voĭtenko
authors.forename: L N
authors.initials: LN
authors.lastname: Trut
mesh_terms: D000374:Aggression / Q000502:physiology; D000818:Animals; D000829:Animals, Domestic / Q000235:genetics* / Q000378:metabolism; D001921:Brain / Q000201:enzymology / Q000378:metabolism; D005589:Foxes / Q000235:genetics* / Q000378:metabolism; D007700:Kinetics; D008297:Male; D008995:Monoamine Oxidase / Q000378:metabolism*; D011985:Receptors, Serotonin / Q000378:metabolism*; D012641:Selection, Genetic; D012701:Serotonin / Q000378:metabolism*; D014365:Tryptophan Hydroxylase / Q000378:metabolism*
chemical_list: D011985:Receptors, Serotonin; D012701:Serotonin; D014365:Tryptophan Hydroxylase; D008995:Monoamine Oxidase
vernacular_title: Vliianie domestikatsii serebristo-chernykh lisits na osnovnye fermenty metabolizma serotonina i serotoninovye retseptory.