title: Selective reinnervation of regenerating mixed nerve fibres across a silicone tube gap. Further experimental evidence of neurotropism.
abstract: This study investigated specific regeneration of a mixed motor and sensory nerve by the method of spinal dorsal root ganglions resection. A 10 mm segment of tibial nerve was resected and the nerve ends inserted in a silicone tube. Fourteen weeks later, dorsal root ganglia from L6 to S1 were resected on the experiment side. Twenty weeks later, the regenerating motor nerve fibres of mixed nerves selectively grew into motor branches. The rate of misdirected growth in mixed nerves was less than 6%. These results suggest that regenerating motor and sensory axons of mixed nerves are able to select their distal target organs accurately. Better results may be obtained using the entubulation repair method.
authors.affiliation: Department of Orthopaedic Surgery, Air Force General Hospital, Beijing, People's Republic of China.
authors.forename: Z J
authors.initials: ZJ
authors.lastname: Luo
authors.forename: S B
authors.initials: SB
authors.lastname: Lu
mesh_terms: D000818:Animals; D004285:Dogs; D005727:Ganglia, Spinal / Q000601:surgery; D009046:Motor Neurons / Q000166:cytology / Q000502:physiology*; D009416:Nerve Regeneration; D009475:Neurons, Afferent / Q000166:cytology / Q000502:physiology*; D012828:Silicones; D013979:Tibial Nerve / Q000166:cytology / Q000502:physiology / Q000601:surgery
chemical_list: D012828:Silicones