Binding Kinetics for Biosensor Applications Utilizing Fractals: A Categorization
Analyte-receptor binding reactions occurring on biosensor surfaces are categorized using a fractal analysis. Both a single- and a dual-fractal analysis are utilized to describe the analyte-receptor binding kinetics. The three categories presented to describe the binding kinetics include (a) case I-only a single-fractal analysis is utilized, (b) case II-a single- and a dual-fractal analysis are utilized (implying a change in the binding mechanism), and (c) case III-only a dual-fractal analysis is utilized. This is an initial attempt to categorize surface binding kinetics. The categorization provides one possible means of classifying analyte-receptor reactions occurring on biosensor surfaces. The analysis should help to improve biosensor performance parameters. The analysis is, in general, extendable to analyte-receptor reactions occurring on other surfaces.
Sadana
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Chemical Engineering Department, University of Mississippi, University, Mississippi, 38677-9740