title: Prophylactic treatment of migraine with bisoprolol: a placebo-controlled study.
abstract: The objective of the present study was to assess the efficacy of bisoprolol in migraine prophylaxis. A double-blind placebo-controlled study was conducted in 226 patients with migraine with or without aura, a migraine history of at least 2 years at least 3 documented attacks during the 28 days run-in period. The duration of treatment was 12 weeks following an initial 28 days' run-in period. Patients reported the number of attacks and their severity in a diary. Treatment with bisoprolol 5 mg resulted in a significant reduction in the frequency of migraine attacks (39% vs 22%) compared to placebo treatment (p < 0.05). Treatment had no effect on the duration and severity of the attacks. Bisoprolol was well tolerated.
authors.affiliation: E. Merck Nederland b.v. Amsterdam, The Netherlands.
authors.forename: L L
authors.initials: LL
authors.lastname: van de Ven
authors.forename: C L
authors.initials: CL
authors.lastname: Franke
authors.forename: P J
authors.initials: PJ
authors.lastname: Koehler
mesh_terms: D000293:Adolescent; D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D000328:Adult; D017298:Bisoprolol / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D004311:Double-Blind Method; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000188:drug therapy / Q000517:prevention & control*
chemical_list: D000319:Adrenergic beta-Antagonists; D017298:Bisoprolol