Some properties of the hazard function of the two-mutation clonal expansion model.
We discuss the hazard function of the two-mutation clonal expansion model with time-dependent parameters, with particular emphasis on identifiability of the parameters. We explicitly construct identifiable parameter combinations, and illustrate the properties of the hazard function under perturbations of the underlying biological parameters.
Heidenreich
W F
WF
GSF-National Research Center for Environment and Health, Institute for Radiation Protection, Neuherberg, Germany.
Luebeck
E G
EG
Moolgavkar
S H
SH
D000818:Animals; D003043:Cocarcinogenesis; D006801:Humans; D008433:Mathematics; D008954:Models, Biological; D009154:Mutation; D016016:Proportional Hazards Models; D012306:Risk