title: Chromosome aberrations after radiotherapy in patients treated for non Hodgkin's lymphoma.
abstract: Chromosome aberrations were evaluated in the lymphocytes of 30 patients who had undergone radiotherapy several years before for non-Hodgkin's lymphoma. Twelve had received 20 Gy over the entire abdomen (group I), 12 wholebody irradiation at 1.5 Gy (group II) and 6 wholebody irradiation at 15 Gy (group III). Unirradiated patients seen for cytogenetic analysis during the same period served as controls. Overall results for the irradiated population were 13/27 (48%) evaluable patients with chromosome aberrations and 50/710 (7%) abnormal cells for a total of 73 aberrations (unstable: 35, stable: 38). The frequency of aberrations was statistically higher in group I (12% of cells) than in groups II (3.5%, p < 0.0001) and III (2.5%, p < 0.0002). Differences in irradiation dose and volume may account for the variations between groups.
authors.affiliation: Service de Radiothérapie, Site Hospitalier Nord de Nantes, Saint-Herblain, France.
authors.forename: M A
authors.initials: MA
authors.lastname: Mahé
authors.forename: M J
authors.initials: MJ
authors.lastname: André
authors.forename: E
authors.initials: E
authors.lastname: Moyon
authors.forename: A
authors.initials: A
authors.lastname: Le Mevel
authors.forename: P
authors.initials: P
authors.lastname: Soubeyran
authors.forename: M
authors.initials: M
authors.lastname: Hamidou
authors.forename: N
authors.initials: N
authors.lastname: Milpied
authors.forename: S
authors.initials: S
authors.lastname: Bourdin
authors.forename: J C
authors.initials: JC
authors.lastname: Cuillière
authors.forename: J F
authors.initials: JF
authors.lastname: Chatal
mesh_terms: D016022:Case-Control Studies; D002869:Chromosome Aberrations; D006801:Humans; D008214:Lymphocytes / Q000528:radiation effects*; D008224:Lymphoma, Follicular / Q000235:genetics / Q000532:radiotherapy*; D011878:Radiotherapy / Q000009:adverse effects