Lack of effect of vitamin E on serum creatine phosphokinase in patients with long-term tardive dyskinesia.
Changes in serum creatine phosphokinase have been associated with exacerbation of tardive dyskinesia. Vitamin E, a drug suggested to be effective in the treatment of tardive dyskinesia, has been implicated as a possible cause of increased creatine phosphokinase levels. Ten patients with long-term tardive dyskinesia were treated with vitamin E in a double-blind, placebo-controlled crossover study. Vitamin E blood levels and creatine phosphokinase serum levels were monitored at various phases during the study. There were no significant differences between vitamin E and placebo treated patients in their abilities to affect tardive dyskinesia or to influence creatine phosphokinase levels. These data do not support the hypothesis that administration of vitamin E may alter creatine phosphokinase levels in patients with long-term tardive dyskinesia.
Dorevitch
A
A
Talbieh Mental Health Center, Jerusalem, Israel.
Lerner
V
V
Shalfman
M
M
Kalian
M
M
D000368:Aged; D003402:Creatine Kinase / Q000097:blood*; D018592:Cross-Over Studies; D004311:Double-Blind Method; D004409:Dyskinesia, Drug-Induced / Q000188:drug therapy / Q000201:enzymology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012559:Schizophrenia / Q000150:complications / Q000201:enzymology; D013997:Time Factors; D014810:Vitamin E / Q000493:pharmacokinetics / Q000494:pharmacology* / Q000627:therapeutic use
D014810:Vitamin E; D003402:Creatine Kinase