[What is/are the function(s) of trefoil peptides?].
pS2, SP and ITF have been identified in the eighties. These peptides share a consensus proteic domain including 3 disulfide bridges leading to a 3 loop structure and subsequently to their name of trefoil peptides. While they are normally expressed in restricted parts of the gastrointestinal tract, ectopic expression is also observed during gastrointestinal ulcerations and in various carcinomas. To date, from numerous studies performed in vitro and in vivo, their functions in these pathologies begin to be elucidated.
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CNRS-INSERM, Université Louis-Pasteur, Ilikirch, France.
D000818:Animals; D001943:Breast Neoplasms / Q000503:physiopathology; D004064:Digestive System / Q000378:metabolism; D004068:Digestive System Physiological Phenomena; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism*; D015870:Gene Expression; D016147:Genes, Tumor Suppressor; D006133:Growth Substances / Q000235:genetics / Q000502:physiology*; D006801:Humans; D066298:In Vitro Techniques; D007413:Intestinal Mucosa / Q000378:metabolism*; D051379:Mice; D008822:Mice, Transgenic; D008969:Molecular Sequence Data; D009077:Mucins; D009124:Muscle Proteins; D009479:Neuropeptides; D010455:Peptides / Q000235:genetics / Q000502:physiology*; D011506:Proteins / Q000235:genetics / Q000378:metabolism*; D013274:Stomach Neoplasms / Q000503:physiopathology; D000071163:Trefoil Factor-1; D000071164:Trefoil Factor-2; D000071165:Trefoil Factor-3; D025521:Tumor Suppressor Proteins
D006133:Growth Substances; D009077:Mucins; D009124:Muscle Proteins; D009479:Neuropeptides; D010455:Peptides; D011506:Proteins; C051838:TFF1 protein, human; C099037:TFF3 protein, rat; D000071163:Trefoil Factor-1; D000071164:Trefoil Factor-2; D000071165:Trefoil Factor-3; D025521:Tumor Suppressor Proteins
Quelle(s) fonction(s) pour les peptides dits "en feuille de trèfle"?