[Receptors for factors of the VEGF (Vascular Endothelial Growth Family)].
Growth factors of the VEGF (vascular endothelial growth factor) family comprises 4 well characterized members that play a crucial role in the biology of blood vessels. They interact with 3 high affinity tyrosine kinase receptors (FLT1/VEGFR1, FLK1/KDR/VEGFR2, FLT4/VEGFR3). VEGF/VEGFR interactions have essential functions in blood vessel formation during development, specific phases of adult life, and in some pathological processes with neo-vascularization such as tumor growth.
Fournier
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E
Laboratoire d'oncologie moléculaire. INSERM U. 119, Marseille, France.
Birnbaum
D
D
Borg
J P
JP
D000328:Adult; D016228:Endothelial Growth Factors / Q000235:genetics / Q000502:physiology; D005786:Gene Expression Regulation; D006801:Humans; D009369:Neoplasms / Q000098:blood supply / Q000473:pathology; D009389:Neovascularization, Pathologic / Q000503:physiopathology; D018919:Neovascularization, Physiologic / Q000502:physiology; D020794:Receptor Protein-Tyrosine Kinases / Q000502:physiology; D017978:Receptors, Growth Factor / Q000502:physiology
D016228:Endothelial Growth Factors; D017978:Receptors, Growth Factor; D020794:Receptor Protein-Tyrosine Kinases
Les récepteurs pour les facteurs de la famille du VEGF.