title: Design of aromatic inhibitors of influenza virus neuraminidase.
abstract: Structure-based drug design, a terminology used to describe rational drug design by complementing the structure, spatially and chemically, of the target macromolecule, is rapidly developing as one of the innovative approaches to drug discovery. A growing volume of protein structure data and new techniques of protein structure determination make this all possible. The method of structure-based drug design and a specific example of the design of influenza virus neuraminidase is briefly presented. A whole new class of influenza virus neuraminidase inhibitors has been designed that can potentially be developed as antiinfluenza drugs.
authors.affiliation: Center for Macromolecular Crystallography, Department of Microbiology, University of Alabama at Birmingham, 35294, USA.
authors.forename: M
authors.initials: M
authors.lastname: Luo
authors.forename: G M
authors.initials: GM
authors.lastname: Air
authors.forename: W J
authors.initials: WJ
authors.lastname: Brouillette
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis*; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000138:chemical synthesis*; D009439:Neuraminidase / Q000037:antagonists & inhibitors* / Q000737:chemistry; D009975:Orthomyxoviridae / Q000187:drug effects* / Q000201:enzymology
chemical_list: D000998:Antiviral Agents; D004791:Enzyme Inhibitors; D009439:Neuraminidase