Endocrine functions in young men exposed for one night to a 50-Hz magnetic field. A circadian study of pituitary, thyroid and adrenocortical hormones.
In recent years, some epidemiologic studies have suggested that extremely low frequency magnetic and electric fields might affect human health, and, in particular, that the incidence of certain types of cancer, depression, and miscarriage might increase among individuals living or working in environments exposed to such fields. Work in our laboratory studies whether and how changes in the electromagnetic environment might affect human health. The study presented here was designed to look for possible effects of acute exposure to 50-Hz linearly polarized magnetic fields (10 microT) on the hormones of the hypothalamic-pituitary-thyroid and hypothalamic-pituitary-adrenal axes. Thirty-two young men (20-30 years old) were divided into two groups (sham-exposed or control group, and exposed group) of 16 subjects each. All subjects participated in two 24-hour experiments to evaluate the effects of both continuous and intermittent (one hour "off" and one hour "on" with the field switched "on" and "off" every 15 seconds) exposure to linearly polarized magnetic fields. The subjects were exposed to the magnetic field (generated by three Helmholtz coils per bed) from 2300 to 0800 while recumbent. Blood samples were collected during each session at 3 hour intervals from 1100 to 2000 and hourly from 2200 to 0800. Total urine was collected every 3 hours from 0800 to 2300 and then again at 0800. No significant differences were observed between sham-exposed and exposed men for any of the parameters measured: thyroid-stimulating hormone, follicle-stimulating hormone, luteinizing hormone, triiodothyronine, thyroxine, free triiodothyronine, free thyroxine, thyroxine-binding globulin, cortisol, 17-hydroxycorticosteroids (17-OH-CS) and TBK. These results suggest that acute exposure to either continuous or intermittent 50-Hz linearly polarized magnetic fields of 10 microT does not affect, at least under our experimental conditions, these endocrine functions or their circadian rhythmicity in healthy young men.
Selmaoui
B
B
Faculté de Médecine Pitié-Salpêtrière, Service de Biochimie Médicale, Paris, France.
Lambrozo
J
J
Touitou
Y
Y
D015065:17-Hydroxycorticosteroids / Q000652:urine; D000302:Adrenal Cortex / Q000502:physiology / Q000528:radiation effects*; D000328:Adult; D002940:Circadian Rhythm; D004574:Electromagnetic Fields / Q000009:adverse effects*; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007030:Hypothalamo-Hypophyseal System / Q000502:physiology / Q000528:radiation effects*; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D010913:Pituitary-Adrenal System / Q000502:physiology / Q000528:radiation effects*; D012016:Reference Values; D013961:Thyroid Gland / Q000502:physiology / Q000528:radiation effects*; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood; D013975:Thyroxine-Binding Proteins / Q000032:analysis; D014284:Triiodothyronine / Q000097:blood
D015065:17-Hydroxycorticosteroids; D013975:Thyroxine-Binding Proteins; D014284:Triiodothyronine; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D013972:Thyrotropin; D013974:Thyroxine; D006854:Hydrocortisone