Islet regeneration in IFNgamma transgenic mice.
The adult pancreas is a developmentally stable organ with limited mitotic activity. This minimal mitotic activity proves critical in insulin-dependent diabetes mellitus (IDDM) since the pathogenesis is characterized by a selective and permanent destruction of islet beta cells. The IFNgamma transgenic mouse model of islet regeneration elucidates the differentiation pathway involved in the regeneration of functional beta cells from ductal precursors and reveals the functional plasticity of the adult pancreas.
Jones
E M
EM
The Scripps Research Institute, Department of Immunology, La Jolla, California 92037, USA.
Sarvetnick
N
N
D000818:Animals; D007371:Interferon-gamma / Q000235:genetics*; D007515:Islets of Langerhans / Q000502:physiology*; D051379:Mice; D008822:Mice, Transgenic / Q000502:physiology*; D011994:Recombinant Proteins; D012038:Regeneration / Q000502:physiology*
D011994:Recombinant Proteins; D007371:Interferon-gamma