Alternatamides A-D: new bromotryptamine peptide antibiotics from the Atlantic marine bryozoan Amathia alternata.
Four new bromotryptamine peptides, alternatamides A-D (1-4), have been isolated from the Atlantic bryozoan Amathia alternata. The structures of the alternatamides were assigned primarily on the basis of 2D NMR data. The absolute stereochemistry of the N-methylleucine amino acid was shown to be L (2'S) by hydrolysis and comparison with standards. The alternatamides show modest antibacterial activities against several Gram-positive bacteria.
Lee
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Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California at San Diego, La Jolla 92093-0236, USA.
Fenical
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Lindquist
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D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D007448:Invertebrates / Q000737:chemistry*; D008386:Marine Biology; D010455:Peptides; D013057:Spectrum Analysis; D013237:Stereoisomerism
D000900:Anti-Bacterial Agents; D010455:Peptides