Effects of dehydroepiandrosterone in rats injected with streptozotocin during the neonatal period.
Control rats and diabetic animals injected with streptozotocin during the neonatal period were either maintained on a standard diet or given access to food supplemented with dehydroepiandrosterone (DHEA, 0.2%) for 11 days before sacrifice. In both control and diabetic rats, DHEA feeding augmented the activity of the mitochondrial FAD-linked glycerophosphate dehydrogenase and cytosolic NADP-linked malate dehydrogenase in liver, but not so in either the parotid gland or pancreatic islets. DHEA lowered, in both control and diabetic rats, the ratio between D-glucose oxidation and utilization and the rate of insulin release in pancreatic islets exposed to a high concentration of D-glucose, as well as the insulin concentration and insulin/glucose ratio in plasma. These findings support the view that, in diabetes, DHEA, by increasing sensitivity to insulin, may allow islet B-cells to avoid the otherwise unfavorable consequences of chronic hyperactivity.
Giroix
M H
MH
Laboratory of Physiopathology of Nutrition, Centre National de la Recherche Scientifique URA, Université René Diderot, Paris, France.
Malaisse-Lagae
F
F
Portha
B
B
Sener
A
A
Malaisse
W J
WJ
D000284:Administration, Oral; D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism*; D001786:Blood Glucose / Q000187:drug effects; D003687:Dehydroepiandrosterone / Q000008:administration & dosage / Q000494:pharmacology*; D005527:Food, Fortified; D005993:Glycerolphosphate Dehydrogenase / Q000187:drug effects; D007328:Insulin / Q000096:biosynthesis / Q000097:blood; D007515:Islets of Langerhans / Q000201:enzymology; D008099:Liver / Q000201:enzymology; D008297:Male; D010306:Parotid Gland / Q000201:enzymology; D051381:Rats; D017208:Rats, Wistar; D013311:Streptozocin / Q000008:administration & dosage
D001786:Blood Glucose; D007328:Insulin; D003687:Dehydroepiandrosterone; D013311:Streptozocin; D005993:Glycerolphosphate Dehydrogenase