Pregnancy-induced hypertension and hyaline membrane disease.
OBJECTIVE
(1) To determine whether the incidence of hyaline membrane disease (HMD) is different among premature babies of pre-eclamptic women and those of normotensive controls; (2) to determine the relative risk (RR) of HMD according to the severity of pre-eclampsia and gestational age.


METHODS
A retrospective and prospective cohort of 271 pre-eclamptic women and 271 normotensive controls, with gestational age between 28 and 34 weeks was studied, including only singleton pregnancies, live fetuses and well-documented gestational age. Exclusion criteria were ruptured membranes > 24 h, other maternal diseases and previous use of corticosteroids. Statistical analysis included relative risk and multiple logistic regression model.


RESULTS
The RR of HMD for babies of pre-eclamptic women was 0.96 (95% CI: 0.78-1.17), and remained unchanged after controlling for gestational age and multiple logistic regression analysis.


CONCLUSIONS
Preterm babies of pre-eclamptic mothers had the same probability of having HMD as newborns of normotensive mothers.
Carvalho
M A
MA
Instituto Materno-Infantil de Pernambuco (IMIP), Recife, Brazil.
Faúndes
A
A
Santos
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LC
D000328:Adult; D015331:Cohort Studies; D005260:Female; D005865:Gestational Age; D006801:Humans; D006819:Hyaline Membrane Disease / Q000453:epidemiology / Q000209:etiology*; D015994:Incidence; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000453:epidemiology; D016015:Logistic Models; D011225:Pre-Eclampsia / Q000150:complications*; D011247:Pregnancy; D012306:Risk