[The effect of serotonin antibodies on the development of a neuropathic pain syndrome].
Serotoninergic and catecholaminergic neurotransmitter systems of the brain play an important role in the regulation of pain sensitivity. However, there are no data on the involvement of antibodies to the above neurotransmitters is the development of neuropathic pain syndromes. The authors' studies indicated that the development of neuropathic pain syndrome occurring after nerve damage is followed by the formation of serotonin antibodies and their enhanced induction caused by immunization of animals with serotonin-protein conjugated antigen aggravates the pain syndrome. Block and insufficiency of the serotoninergic antinociceptive system may be a cause of the progression of the pain syndrome due to serotonin antibodies.
Igon'kina
S I
SI
Kryzhanovskiĭ
G N
GN
Zinkevich
V A
VA
Basharova
L A
LA
Vetrilé
L A
LA
Evseev
V A
VA
Reshetniak
V K
VK
Kukushkin
M L
ML
D000818:Animals; D001323:Autoantibodies / Q000097:blood*; D004195:Disease Models, Animal; D007114:Immunization / Q000379:methods; D008297:Male; D010146:Pain / Q000209:etiology* / Q000276:immunology; D051381:Rats; D017208:Rats, Wistar; D012584:Sciatic Nerve / Q000293:injuries; D012701:Serotonin / Q000276:immunology*; D013577:Syndrome; D013997:Time Factors
D001323:Autoantibodies; D012701:Serotonin
Vliianie antitel k serotoninu na razvitie neĭropaticheskogo bolevogo sindroma.