Conservative management of osteoradionecrosis.
A retrospective records analysis of 32 patients with mandibular osteoradionecrosis seen between August 1960 and September 1995 was undertaken to determine the effectiveness of nonsurgical/nonhyperbaric oxygen conservative management. Two patients died before final analysis. Of those alive, 65.5% of patients were spared resection, having lesions resolve (48.3%), improve (3.4%), or asymptomatically stabilize (13.8%). Sequestrum production allowing "gentle" removal predicted a more favorable clinical course when managed conservatively compared with nonsequestrating lesions (p < 0.05). Criteria to define clinical osteoradionecrosis are proposed.
Wong
J K
JK
Ontario Cancer Institute/Princess Margaret Hospital, Department of Dentistry, Toronto, Canada.
Wood
R E
RE
McLean
M
M
D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000532:radiotherapy; D016371:Cranial Irradiation / Q000009:adverse effects; D017050:Episode of Care; D005260:Female; D006258:Head and Neck Neoplasms / Q000532:radiotherapy; D006801:Humans; D008297:Male; D008336:Mandibular Diseases / Q000209:etiology / Q000628:therapy*; D008875:Middle Aged; D010025:Osteoradionecrosis / Q000209:etiology / Q000628:therapy*; D017063:Outcome Assessment, Health Care; D011379:Prognosis; D011829:Radiation Dosage; D012189:Retrospective Studies; D018709:Statistics, Nonparametric; D009626:Terminology as Topic