Cholecystokinin receptors do not mediate the behavioral effects of lipopolysaccharide in mice.
To test the possible role of cholecystokinin (CCK) in the decrease of social exploration induced by intraperitoneal (IP) injection of lipopolysaccharide (LPS, 100 microg/kg), mice were pretreated with IP or intracerebroventricular (ICV) injection of the CCKA receptor antagonist L-364,718 (3 mg/kg and 10 microg/kg, respectively) and the CCKB receptor antagonist L-365,260 (1 mg/kg and 10 microg/kg, respectively). L-364,718 and L-365,260 did not alter LPS-induced decrease in social investigation, whatever the route of administration, suggesting that endogenous cholecystokinin does not mediate the effect of proinflammatory cytokines on social exploration in mice.
Bluthé
R M
RM
INRA-INSERM U 394, Domaine de Carreire, Bordeaux, France. rose-marie.bluthe@bordeaux.inserm.fr
Michaud
B
B
Kelley
K W
KW
Dantzer
R
R
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001570:Benzodiazepinones / Q000008:administration & dosage / Q000494:pharmacology; D003864:Depression, Chemical; D020109:Devazepide; D004731:Endotoxins / Q000008:administration & dosage / Q000494:pharmacology*; D005106:Exploratory Behavior / Q000187:drug effects; D006727:Hormone Antagonists / Q000494:pharmacology; D007274:Injections, Intraperitoneal; D007276:Injections, Intraventricular; D008070:Lipopolysaccharides / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D010671:Phenylurea Compounds; D011949:Receptors, Cholecystokinin / Q000037:antagonists & inhibitors*; D012919:Social Behavior
D001570:Benzodiazepinones; D004731:Endotoxins; D006727:Hormone Antagonists; D008070:Lipopolysaccharides; D010671:Phenylurea Compounds; D011949:Receptors, Cholecystokinin; C058121:L 365260; C044101:endotoxin, Escherichia coli; D020109:Devazepide