title: Human immunodeficiency virus-1 infection in neonates: correlation of plasma and cellular viremia and clinical outcome. French Pediatric Cohort Study Group.
abstract: Among human immunodeficiency virus-1 (HIV-1) vertically infected children, two patterns of disease progression have been observed: about 25% develop a severe immunodeficiency within the first 2 years of life; the rest experience a slower progression, like adults. We have assessed infectious viral burden in infected neonates through the French National Prospective Study. Plasma and cell-associated viremia were assayed by endpoint-dilution cultures in samples from 46 infants followed prospectively from birth. Plasma and cell-associated viral burden were found to be significantly higher in rapid progressing infants than in non-progressing infants in the first months of life: before the age of 2 months, between 2 and 4 months of age and by the age of 6 months. Moreover, among the non-progressing children, the infectious viral burden before the age of 4 months was predictive of the viral burden measured after the age of 12 months. In conclusion, this work demonstrates that infectious viral load is a reliable predictive marker for rapid progression to AIDS in infants and could be useful for initiating antiretroviral therapy.
authors.affiliation: Laboratoire de Virologie, Hôpital Necker-Enfants Malades, Paris, France.
authors.forename: C
authors.initials: C
authors.lastname: Rouzioux
authors.forename: M
authors.initials: M
authors.lastname: Burgard
authors.forename: M L
authors.initials: ML
authors.lastname: Chaix
authors.forename: C
authors.initials: C
authors.lastname: Delamare
authors.forename: N
authors.initials: N
authors.lastname: Cirau
authors.forename: B
authors.initials: B
authors.lastname: Bouiller
authors.forename: S
authors.initials: S
authors.lastname: Cateloy
authors.forename: M C
authors.initials: MC
authors.lastname: Allemon
authors.forename: C
authors.initials: C
authors.lastname: Broyart
authors.forename: N
authors.initials: N
authors.lastname: Ciraru
authors.forename: C
authors.initials: C
authors.lastname: Floch
authors.forename: P
authors.initials: P
authors.lastname: Lelorier
authors.forename: E
authors.initials: E
authors.lastname: Lachassine
authors.forename: F
authors.initials: F
authors.lastname: Mazy
authors.forename: P
authors.initials: P
authors.lastname: Narcy
authors.forename: J
authors.initials: J
authors.lastname: Saillant
authors.forename: J L
authors.initials: JL
authors.lastname: Salomon
authors.forename: H
authors.initials: H
authors.lastname: Seaume
authors.forename: P
authors.initials: P
authors.lastname: Talon
authors.forename: M J
authors.initials: MJ
authors.lastname: Mayaux
authors.forename: S
authors.initials: S
authors.lastname: Blanche
mesh_terms: D000367:Age Factors; D018450:Disease Progression; D015658:HIV Infections / Q000097:blood / Q000151:congenital* / Q000503:physiopathology; D015497:HIV-1; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D011237:Predictive Value of Tests; D011446:Prospective Studies; D019562:Viral Load; D014766:Viremia