Antiviral activity of cyclopentenone prostanoids.
Cyclopentenone prostanoids inhibit virus replication by turning on an intracellular defence response that involves the induction of cytoprotective heat-shock proteins, the modification of viral glycoprotein maturation and the control of NF-kappa B activation. These molecules represent an interesting model for the development of novel antiviral drugs that can affect different targets during the virus life cycle.
Santoro
M G
MG
Institute of Experimental Medicine, CNR, Rome, Italy. santoro@biocell.irmkant.rm.cnr.it
D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D002460:Cell Line; D003517:Cyclopentanes / Q000494:pharmacology*; D006801:Humans; D016328:NF-kappa B / Q000187:drug effects / Q000378:metabolism; D011453:Prostaglandins / Q000494:pharmacology*; D014764:Viral Proteins / Q000037:antagonists & inhibitors; D014779:Virus Replication / Q000187:drug effects
D000998:Antiviral Agents; D003517:Cyclopentanes; D016328:NF-kappa B; D011453:Prostaglandins; D014764:Viral Proteins; C013905:cyclopentenone