title: [Aplastic anemia. Alternative treatment by bone marrow transplantation].
abstract: We report a case of a 25-year-old woman, with the diagnosis of severe aplastic anemia without a histocompatible sibling donor for bone marrow transplantation. The patient has been treated successfully with a combination of two immunosuppressive agents, cyclosporine and antilymphocyte globulin, after not responding to primary therapy with corticosteroids and growth factors. She showed a complete response to treatment, with transfusional independence, after a follow-up of 14 months. The pathophysiology of aplastic anemia, the mechanism of action and secondary effects of these treatments are discussed.
authors.affiliation: Serviço Medicina I, Hospital de Santa maria, Lisboa.
authors.forename: T
authors.initials: T
authors.lastname: Fonseca
authors.forename: J
authors.initials: J
authors.lastname: Raposo
authors.forename: B
authors.initials: B
authors.lastname: Gomez
authors.forename: J J
authors.initials: JJ
authors.lastname: d'Oliveira
authors.forename: J M
authors.initials: JM
authors.lastname: de Lacerda
mesh_terms: D000328:Adult; D000741:Anemia, Aplastic / Q000175:diagnosis / Q000628:therapy*; D001706:Biopsy; D016026:Bone Marrow Transplantation; D001842:Bone and Bones / Q000473:pathology; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007165:Immunosuppression Therapy
vernacular_title: Anemia aplástica. Tratamento alternativo à transplantação medular.