title: Cholecystokinin receptors do not mediate the behavioral effects of lipopolysaccharide in mice.
abstract: To test the possible role of cholecystokinin (CCK) in the decrease of social exploration induced by intraperitoneal (IP) injection of lipopolysaccharide (LPS, 100 microg/kg), mice were pretreated with IP or intracerebroventricular (ICV) injection of the CCKA receptor antagonist L-364,718 (3 mg/kg and 10 microg/kg, respectively) and the CCKB receptor antagonist L-365,260 (1 mg/kg and 10 microg/kg, respectively). L-364,718 and L-365,260 did not alter LPS-induced decrease in social investigation, whatever the route of administration, suggesting that endogenous cholecystokinin does not mediate the effect of proinflammatory cytokines on social exploration in mice.
authors.affiliation: INRA-INSERM U 394, Domaine de Carreire, Bordeaux, France. rose-marie.bluthe@bordeaux.inserm.fr
authors.forename: R M
authors.initials: RM
authors.lastname: Bluthé
authors.forename: B
authors.initials: B
authors.lastname: Michaud
authors.forename: K W
authors.initials: KW
authors.lastname: Kelley
authors.forename: R
authors.initials: R
authors.lastname: Dantzer
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001570:Benzodiazepinones / Q000008:administration & dosage / Q000494:pharmacology; D003864:Depression, Chemical; D020109:Devazepide; D004731:Endotoxins / Q000008:administration & dosage / Q000494:pharmacology*; D005106:Exploratory Behavior / Q000187:drug effects; D006727:Hormone Antagonists / Q000494:pharmacology; D007274:Injections, Intraperitoneal; D007276:Injections, Intraventricular; D008070:Lipopolysaccharides / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D010671:Phenylurea Compounds; D011949:Receptors, Cholecystokinin / Q000037:antagonists & inhibitors*; D012919:Social Behavior
chemical_list: D001570:Benzodiazepinones; D004731:Endotoxins; D006727:Hormone Antagonists; D008070:Lipopolysaccharides; D010671:Phenylurea Compounds; D011949:Receptors, Cholecystokinin; C058121:L 365260; C044101:endotoxin, Escherichia coli; D020109:Devazepide