The behavior of endometrial hyperplasia: a prospective study. Endometrial Hyperplasia Study Group.
OBJECTIVE
To clarify the behavior of endometrial hyperplasia in a prospective study.


METHODS
Fifty-one patients with endometrial hyperplasia were followed up for 6 months. Samples of endometrial tissues were taken by uterine endometrial biopsy every 4 weeks during the first 3 months and at the end of follow-up.


RESULTS
In 69% (35/51) of the patients histological picture of the endometrium became normal during the observation period. The lesions persisted in 17% (6/35) of the patients with simple hyperplasia, in 25% (1/4) of those with complex hyperplasia, in 14% (1/7) of those with simple atypical hyperplasia, and in 80% (4/5) of the patients with complex atypical hyperplasia. In the remaining 3 patients with simple hyperplasia, the lesions progressed to complex atypical hyperplasia by the end of follow-up, after showing a normal endometrium.


CONCLUSIONS
Most cases of endometrial hyperplasia, except for complex atypical hyperplasia, disappeared spontaneously within a short period of time.
Terakawa
N
N
Department of Obstetrics and Gynecology, Tottori University School of Medicine, Yonago, Japan.
Kigawa
J
J
Taketani
Y
Y
Yoshikawa
H
H
Yajima
A
A
Noda
K
K
Okada
H
H
Kato
J
J
Yakushiji
M
M
Tanizawa
O
O
Fujimoto
S
S
Nozawa
S
S
Takahashi
T
T
Hasumi
K
K
Furuhashi
N
N
Aono
T
T
Sakamoto
A
A
Furusato
M
M
D000328:Adult; D001706:Biopsy; D004714:Endometrial Hyperplasia / Q000473:pathology*; D004717:Endometrium / Q000473:pathology; D005260:Female; D006801:Humans; D008875:Middle Aged; D017698:Postmenopause; D017697:Premenopause; D011446:Prospective Studies; D012075:Remission, Spontaneous