Pulvinatal, a novel bioactive metabolite from the basidiomycete Nidularia pulvinata (Schw.) Fr.
Pulvinatal (1) was isolated from fermentations of Nidularia pulvinata as an inducer of differentiation of HL-60 promyelocytic leukemia cells. Its structure was elucidated by spectroscopic methods. In addition, N. pulvinata was found to produce 2,4,5-trihydroxy-6-methyl-benzenecarbaldehyde (2) and orsellinic acid (3). Pulvinatal exhibits weak antifungal and only marginal cytotoxic activities.
Becker
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U
Lehrbereich Biotechnologie, Universität Kaiserslautern, Germany.
Erkel
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Kocksch
G
G
Anke
T
T
Sterner
O
O
D000935:Antifungal Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D001487:Basidiomycota; D002454:Cell Differentiation / Q000187:drug effects; D005285:Fermentation; D005658:Fungi / Q000187:drug effects*; D018922:HL-60 Cells / Q000166:cytology / Q000187:drug effects; D006801:Humans; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D011714:Pyrans / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D014407:Tumor Cells, Cultured
D000935:Antifungal Agents; D000972:Antineoplastic Agents, Phytogenic; D011714:Pyrans; C107456:pulvinatal