title: Stent-grafts for revision of TIPS stenoses and occlusions: a clinical pilot study.
abstract: OBJECTIVE
  To assess the clinical and technical results of stent-graft placement for revision of transjugular intrahepatic portosystemic shunt (TIPS) stenoses and occlusions.
  
  
  METHODS
  Six patients who developed recurrent TIPS stenosis or occlusion of the parenchymal tract underwent shunt revision with use of polytetrafluoroethylene (PTFE) stent-grafts anchored at both ends by Z stents and centrally supported by Wallstents.
  
  
  RESULTS
  Before graft placement, mean primary patency was 50 days (range, 9-100 days). Patients underwent one to eight revisions with angioplasty or stent placement (mean, 3.2). Three patients had biliary-TIPS fistulas documented with use of a prototype double occlusion balloon catheter. Stent-grafts were successfully placed within the obstructed shunt, creating an excellent lumen in all cases. The portosystemic gradient was decreased from a mean of 24.3 mm Hg (range, 12-35 mm Hg) to a mean of 10.3 mm Hg (range, 7-16 mm Hg). Five of six patients were asymptomatic and no complications occurred (median clinical follow-up, 331 days). One patient died of pre-existing multi-organ system failure. The duration of primary patency after stent-grafting was improved (mean, 229 days; range, 27-324 days) and the difference approached statistical significance despite the small sample size (P = .056, paired t test). Three patients remained primarily patent at a mean venographic follow-up of 315 days. One shunt occluded at 1 month from residual thrombus in the portal vein, and one stenosis occurred that was secondary to misplacement of the original stent-graft. Patency was re-established in each of these patients.
  
  
  CONCLUSIONS
  PTFE covered stent-grafts are effective for shunt revision in patients with tract stenosis or occlusion and appear to improve TIPS patency.
authors.affiliation: Dotter Interventional Institute, Oregon Health Sciences University, Portland, USA.
authors.forename: R R
authors.initials: RR
authors.lastname: Saxon
authors.forename: H A
authors.initials: HA
authors.lastname: Timmermans
authors.forename: B T
authors.initials: BT
authors.lastname: Uchida
authors.forename: B D
authors.initials: BD
authors.lastname: Petersen
authors.forename: K G
authors.initials: KG
authors.lastname: Benner
authors.forename: J
authors.initials: J
authors.lastname: Rabkin
authors.forename: F S
authors.initials: FS
authors.lastname: Keller
mesh_terms: D000328:Adult; D000800:Angioplasty, Balloon / Q000295:instrumentation* / Q000379:methods; D005260:Female; D005500:Follow-Up Studies; D006083:Graft Occlusion, Vascular / Q000000981:diagnostic imaging / Q000209:etiology / Q000628:therapy*; D006801:Humans; D006975:Hypertension, Portal / Q000601:surgery; D008297:Male; D008875:Middle Aged; D010690:Phlebography; D010865:Pilot Projects; D011138:Polytetrafluoroethylene; D019168:Portasystemic Shunt, Transjugular Intrahepatic / Q000009:adverse effects*; D012086:Reoperation; D015607:Stents; D016896:Treatment Outcome
chemical_list: D011138:Polytetrafluoroethylene