Two models of acute hepatic failure with extensive hepatic necrosis and blood ammonia elevation in small animals.
Acute hepatic failure models with extensive hepatic necrosis and hyperammonemia were developed in small animals. One model is bases on the retrograde infusion of ethanolamine oleate into the common bile duct of guinea pigs and another is based on the infusion of TNF-lipiodol emulsion into the portal tract of rats.
Watanabe
A
A
Third Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Japan.
Tsuchida
T
T
Kuwabara
Y
Y
D000410:Alanine Transaminase / Q000097:blood; D000641:Ammonia / Q000097:blood*; D000818:Animals; D001663:Bilirubin / Q000097:blood; D003135:Common Bile Duct; D004195:Disease Models, Animal; D004655:Emulsions; D006168:Guinea Pigs; D007459:Iodized Oil / Q000008:administration & dosage; D008099:Liver / Q000473:pathology*; D017114:Liver Failure, Acute / Q000097:blood* / Q000209:etiology* / Q000473:pathology; D008297:Male; D009336:Necrosis; D009829:Oleic Acids / Q000008:administration & dosage; D011169:Portal Vein; D051381:Rats; D014409:Tumor Necrosis Factor-alpha / Q000008:administration & dosage
D004655:Emulsions; D009829:Oleic Acids; D014409:Tumor Necrosis Factor-alpha; D000641:Ammonia; D007459:Iodized Oil; D000410:Alanine Transaminase; D001663:Bilirubin; C033343:ethanolamine oleate