[Reparative characteristics of gastric and duodenal mucosa in ulcer].
Mucosal repair in the stomach and duodenum was assessed clinically and morphologically in various ulcer phases in 475 patients with gastroduodenal ulcer. It was found that poorly scarring ulcers are characterized by severe impairment of regeneration with epithelial proliferation prevailing over its differentiation. Participation of immune system, primarily T-cell component, in regeneration regulation is shown. Helicobacter pylori is not involved in repair. Superoxide dismutase activity in red cells and ulcer edges mucosa is prognostically significant indicating the disease phase, completeness of ulcer process.
Miagkova
L P
LP
Department of Internal Diseases Propedeutics, MMA of IM Sechenov.
Sklianskaia
O A
OA
Lapina
T L
TL
Kon'kov
M I
MI
Alekperov
R T
RT
Kogan
I G
IG
Barsel'
V A
VA
D000328:Adult; D004386:Duodenum / Q000473:pathology* / Q000601:surgery; D016145:Endoscopy, Digestive System; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D015227:Lipid Peroxidation / Q000502:physiology; D008297:Male; D008875:Middle Aged; D010437:Peptic Ulcer / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D013482:Superoxide Dismutase / Q000378:metabolism; D013601:T-Lymphocytes / Q000473:pathology
D013482:Superoxide Dismutase
Kharakter reparatsii slizistoí obolochki zheludka i dvenadtsatiperstnoí kishki pri iazvennoí bolezni.