[The cardioprotective action of the anticonvulsant preparation sodium valproate in disorders of cardiac contractile function caused by acute myocardial infarct in rats].
The preventive and therapeutical effects of sodium valproate (SV), 200 mg/kg, on cardiac contractile disorders (developed pressure, rate-pressure products, dp/dt) were studied in rats having 2-day myocardial infarction (MI). The postinfarction rather than preinfarction use of SV substantially restricted the depressed resting left ventricular function. Given by two regimens, SV increased cardiac resistance to the maximum isometric load induced by 60-sec ligation of the ascending aorta. The cardioprotective effect of the drug was shown due to its positive chronotropic action rather than its inotropic one. Thus, SV may be used as an effective drug for the prevention and treatment of postinfarct cardiac dysfunctions.
Belkina
L M
LM
Korchazhkina
N B
NB
Kamskova
Iu G
IuG
Fomin
N A
NA
D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use*; D001145:Arrhythmias, Cardiac / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D002317:Cardiovascular Agents / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects; D009203:Myocardial Infarction / Q000150:complications* / Q000503:physiopathology; D051381:Rats; D017208:Rats, Wistar; D018709:Statistics, Nonparametric; D014635:Valproic Acid / Q000627:therapeutic use*
D000927:Anticonvulsants; D002317:Cardiovascular Agents; D014635:Valproic Acid
Kardioprotektivnoe deĭstvie protivososudorozhnogo preparata val'proata natriia pri narusheniiakh sokratitel'noĭ funktsii serdtsa, vyzvannye ostrym infarktom miokarda u krys.