title: [The clinical pharmacology of mivacurium].
abstract: Mivacurium is a short-acting, nondepolarising muscle relaxant of the benzylisoquinoline type that undergoes rapid breakdown by plasma cholinesterase. After 2.5 times the ED95 (0.2 mg/kg), tracheal intubation can be accomplished within 2-3 min following injection. The ensuing DUR 25% (i.e., time from injection to 25% recovery of control twitch tension) is three times as long as with succinylcholine. The principal side effects of mivacurium are facial flushing and a transient fall in blood pressure due to moderate histamine release following doses 3-4 times the ED95. In patients with end-stage liver or renal disease as well as those with atypical plasma cholinesterase, the duration of action of mivacurium is prolonged.
authors.affiliation: Klinik und Poliklinik für Anästhesiologie und Operative Intensivmedizin, Universität zu Köln.
authors.forename: C
authors.initials: C
authors.lastname: Diefenbach
authors.forename: H
authors.initials: H
authors.lastname: Mellinghoff
mesh_terms: D000758:Anesthesia; D002802:Cholinesterases / Q000097:blood; D006801:Humans; D007546:Isoquinolines / Q000493:pharmacokinetics / Q000494:pharmacology* / Q000627:therapeutic use; D000077590:Mivacurium; D003473:Neuromuscular Nondepolarizing Agents / Q000493:pharmacokinetics / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D007546:Isoquinolines; D003473:Neuromuscular Nondepolarizing Agents; D000077590:Mivacurium; D002802:Cholinesterases
vernacular_title: Die klinische Pharmakologie von Mivacurium.