title: Multiple simultaneous synthesis of phenolic libraries.
abstract: A series of analogous arrays of small, non-peptidyl, non-oligomeric compounds were synthesized on polystyrene resin. With the aid of a functionally differentiated phenolic scaffold, the batch preparation of unique benzamide and urea resins was accomplished, which were further derivatized in modified 96-well plates. An efficient cleavage reaction of the phenyl benzoate link enabled the isolation of more than 600 phenolic compounds in milligram quantities that were suitable for direct biological screening. The technology described herein represents a facile, economical approach to non-peptidyl chemical diversity.
authors.affiliation: Sphinx Pharmaceuticals, Division of Eli Lilly & Co., Cambridge, MA 02139, USA.
authors.forename: H V
authors.initials: HV
authors.lastname: Meyers
authors.forename: G J
authors.initials: GJ
authors.lastname: Dilley
authors.forename: T L
authors.initials: TL
authors.lastname: Durgin
authors.forename: T S
authors.initials: TS
authors.lastname: Powers
authors.forename: N A
authors.initials: NA
authors.lastname: Winssinger
authors.forename: H
authors.initials: H
authors.lastname: Zhu
authors.forename: M R
authors.initials: MR
authors.lastname: Pavia
mesh_terms: D002625:Chemistry, Organic / Q000295:instrumentation; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D019020:Directed Molecular Evolution / Q000379:methods*; D015195:Drug Design; D004353:Drug Evaluation, Preclinical; D008722:Methods; D015394:Molecular Structure; D010636:Phenols / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D010636:Phenols