Modulation of arterial thrombosis tendency in rats by vitamin K and its side chains.
Vitamin K is involved in the biosynthesis of a number of blood coagulation factors and bone proteins. It has been suggested that the vitamin K requirement of bone tissue is higher than that of the liver. Here we report that in rats very high doses of vitamin K affected neither the blood coagulation characteristics nor the blood platelet aggregation rate. This was observed for both phylloquinone and menaquinone-4. Both vitamers were also tested for their effects on the arterial thrombosis tendency in the rat aorta loop model. The mean obstruction times were prolonged at a high intake of menaquinone-4 (250 mg/kg body weight/day), and shortened after a similarly high phylloquinone regimen. Since (a) both vitamers only differ in their aliphatic side chains; and (b) a similar trend was observed after administration of phytol and geranylgeraniol, we conclude that the modulation of the arterial thrombosis tendency is accomplished by the side chain of vitamin K.
Ronden
J E
JE
Department of Biochemistry and Cardiovascular Research Institute, Maastricht University, Netherlands.
Groenen-van Dooren
M M
MM
Hornstra
G
G
Vermeer
C
C
D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects*; D004032:Diet; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D004195:Disease Models, Animal; D004198:Disease Susceptibility; D004224:Diterpenes / Q000494:pharmacology / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D008297:Male; D010836:Phytol / Q000494:pharmacology / Q000627:therapeutic use; D010974:Platelet Aggregation / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D013927:Thrombosis / Q000097:blood / Q000517:prevention & control*; D014812:Vitamin K / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use* / Q000633:toxicity; D010837:Vitamin K 1 / Q000494:pharmacology; D024482:Vitamin K 2 / Q000031:analogs & derivatives; D014813:Vitamin K Deficiency / Q000150:complications
D004042:Dietary Fats, Unsaturated; D004224:Diterpenes; D024482:Vitamin K 2; D014812:Vitamin K; D010836:Phytol; C030814:menatetrenone; D010837:Vitamin K 1; C017338:geranylgeraniol