Inhibitory effects of shouseiryu-to on two-stage carcinogenesis. II. Anti-tumor-promoting activities of lignans from Asiasarum heterotropoides var. mandshuricum.
Two lignans, asarinin (6) and xanthoxylol (7), were isolated from the radix of Asiasarum heterotropoides var. mandshuricum, which consist of a kampo prescription, Shouseiryu-to, as inhibitors of Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA). These lignans also exhibited remarkable inhibitory effects on a two-stage carcinogenesis test of mouse skin and pulmonary tumors. Furthermore, it was confirmed that these hydrophobic lignans dissolved in the water decoction of Shouseiryu-to, and these lignans might be among the active constituents of this kampo prescription in terms of its anti-tumor-promoting activity.
Takasaki
M
M
Kyoto Pharmaceutical University, Japan.
Konoshima
T
T
Yasuda
I
I
Hamano
T
T
Tokuda
H
H
D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D000956:Antigens, Viral / Q000235:genetics; D002460:Cell Line; D002471:Cell Transformation, Neoplastic / Q000187:drug effects* / Q000235:genetics; D004149:Dioxoles / Q000494:pharmacology*; D005260:Female; D005663:Furans / Q000494:pharmacology*; D017705:Lignans; D008175:Lung Neoplasms / Q000517:prevention & control; D051379:Mice; D008813:Mice, Inbred ICR; D010636:Phenols / Q000494:pharmacology*; D012878:Skin Neoplasms / Q000517:prevention & control; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology
D016588:Anticarcinogenic Agents; D000956:Antigens, Viral; D004149:Dioxoles; C033305:Epstein-Barr virus early antigen; D005663:Furans; D017705:Lignans; D010636:Phenols; C108246:xanthoxylol; D013755:Tetradecanoylphorbol Acetate; C054125:sesamin