Lysophosphatidic acid as a phospholipid mediator: pathways of synthesis.
From very recent studies, including molecular cloning of cDNA coding for membrane receptors, lysophosphatidic acid (LPA) reached the status of a novel phospholipid mediator with various biological activities. Another strong argument supporting this view was the discovery that LPA is secreted from activated platelets, resulting in its appearance in serum upon blood coagulation. The metabolic pathways as well as the enzymes responsible for LPA production are poorly characterized. However, a survey of literature data indicates some interesting issues which might be used as the basis for further molecular characterization of phospholipases A able to degrade phosphatidic acid.
Gaits
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Institut Fédératif de Recherche en Immunologie Cellulaire et Moléculaire, Université Paul Sabatier, INSERM Unité 326, Phospholipides Membranaires, Signalisation Cellulaire et Lipoprotéines, Hôpital Purpan, Toulouse, France.
Fourcade
O
O
Le Balle
F
F
Gueguen
G
G
Gaigé
B
B
Gassama-Diagne
A
A
Fauvel
J
J
Salles
J P
JP
Mauco
G
G
Simon
M F
MF
Chap
H
H
D000818:Animals; D001792:Blood Platelets / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism; D054522:Group VI Phospholipases A2; D006801:Humans; D008246:Lysophospholipids / Q000096:biosynthesis* / Q000378:metabolism; D010712:Phosphatidic Acids / Q000378:metabolism; D010741:Phospholipases A / Q000378:metabolism; D010743:Phospholipids / Q000378:metabolism*
D008246:Lysophospholipids; D010712:Phosphatidic Acids; D010743:Phospholipids; D010741:Phospholipases A; D054522:Group VI Phospholipases A2; C516475:PLA2G6 protein, human