title: The comparative efficacy of stabilized stannous fluoride dentifrice, peroxide/baking soda dentifrice and essential oil mouthrinse for the prevention of gingivitis.
abstract: This double-blind parallel-design clinical study compared the efficacy of a stabilized stannous fluoride dentifrice (Crest Plus Gum Care), baking soda and peroxide (NaF) dentifrice (Mentadent), and essential oil mouthrinse (Listerine) to a conventional NaF dentifrice (Crest) for the control of plaque, gingivitis and gingival bleeding over six months. Following an initial baseline examination and stratification, subjects received a complete oral prophylaxis and were distributed assigned test products. Following three and six months, subjects re-visited the clinic for examinations. Evaluations at baseline and at 3 and 6 months included soft tissue status. Löe-Silness gingivitis/gingival bleeding, Silness-Löe plaque and dental stain. Results subsequent to six months of product use were as follows: At six months, the stabilized stannous fluoride dentifrice was observed to produce statistically significant 17.5% reductions in gingivitis and 27.5% reductions in gingival bleeding relative to the NaF dentifrice. The combination of sodium fluoride dentifrice and essential oil mouthrinse produced statistically significant reductions of 7.4% in gingivitis and 10.8% in plaque as compared with the NaF dentifrice. The stabilized stannous fluoride dentifrice produced statistically significant reductions in both gingivitis (10.8%) and gingival bleeding (23.0%) relative to the combination of sodium fluoride dentifrice and essential oil mouthrinse. The baking soda and peroxide (NaF) dentifrice did not provide reductions in gingivitis, plaque or gingival bleeding as compared with the conventional NaF dentifrice. The stabilized stannous fluoride dentifrice provided statistically significant reductions in gingivitis as compared with the baking soda and peroxide dentifrice following six months of use, and both the essential oil mouthrinse and stabilized stannous fluoride dentifrice provided statistically significant reductions in gingivitis as compared with the baking soda and peroxide dentifrice following three months of use. These results support: 1) the efficacy of stabilized stannous fluoride dentifrice and the combination of sodium fluoride dentifrice and essential oil mouthrinse for the prevention of gingivitis; 2) the superior activity of stabilized stannous fluoride dentifrice as compared with a combination of sodium fluoride dentifrice and essential oil mouthrinse for the control of gingivitis and gingival bleeding; and 3) the lack of efficacy for baking soda and peroxide dentifrice for the control of plaque, gingivitis and gingival bleeding as compared with conventional fluoridated dentifrice.
authors.affiliation: Oral Health Research Institute, Indiana University Indianapolis, USA.
authors.forename: B B
authors.initials: BB
authors.lastname: Beiswanger
authors.forename: S F
authors.initials: SF
authors.lastname: McClanahan
authors.forename: R D
authors.initials: RD
authors.lastname: Bartizek
authors.forename: A C
authors.initials: AC
authors.lastname: Lanzalaco
authors.forename: L A
authors.initials: LA
authors.lastname: Bacca
authors.forename: D J
authors.initials: DJ
authors.lastname: White
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D003773:Dental Plaque / Q000517:prevention & control; D003774:Dental Plaque Index; D003802:Dentifrices / Q000737:chemistry / Q000627:therapeutic use*; D004311:Double-Blind Method; D004338:Drug Combinations; D005260:Female; D005891:Gingivitis / Q000517:prevention & control*; D006801:Humans; D006861:Hydrogen Peroxide / Q000627:therapeutic use; D008297:Male; D009067:Mouthwashes / Q000737:chemistry / Q000627:therapeutic use*; D010512:Periodontal Index; D012459:Salicylates / Q000627:therapeutic use; D017693:Sodium Bicarbonate / Q000627:therapeutic use; D012969:Sodium Fluoride / Q000627:therapeutic use; D013729:Terpenes / Q000627:therapeutic use; D014002:Tin Fluorides / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D003802:Dentifrices; D004338:Drug Combinations; C098761:Mentadent Dentifrice; D009067:Mouthwashes; D012459:Salicylates; D013729:Terpenes; D014002:Tin Fluorides; C057473:Listerine; D017693:Sodium Bicarbonate; D012969:Sodium Fluoride; D006861:Hydrogen Peroxide