Expression of cyclooxygenase-2 mRNA in rat retrosplenial cortex following administration of phencyclidine.
The effect of NMDA receptor antagonist phencyclidine (PCP) on expression of cyclooxygenase (COX)-2 mRNA in the rat brain was studied. Administration of PCP (12.5, 25 or 50 mg/kg, i.p., 6 h) caused marked induction of COX-2 mRNA and heat shock gene hsp-70 mRNA, a marker of neuronal injury, in the retrosplenial cortex, in a dose-dependent manner. These results suggest that COX-2 may play a role in the neurotoxicity of NMDA receptor antagonists.
Hashimoto
K
K
Division of Cortical Function Disorders, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan. hashiken@mxj.meshnet.or.jp
Minabe
Y
Y
Iyo
M
M
D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects; D002540:Cerebral Cortex / Q000737:chemistry / Q000201:enzymology*; D051546:Cyclooxygenase 2; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology*; D005260:Female; D015971:Gene Expression Regulation, Enzymologic / Q000187:drug effects; D018840:HSP70 Heat-Shock Proteins / Q000235:genetics; D017403:In Situ Hybridization; D007527:Isoenzymes / Q000235:genetics*; D010544:Peroxidases / Q000235:genetics; D010622:Phencyclidine / Q000494:pharmacology*; D011451:Prostaglandin-Endoperoxide Synthases / Q000235:genetics*; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors
D018691:Excitatory Amino Acid Antagonists; D018840:HSP70 Heat-Shock Proteins; D007527:Isoenzymes; D012333:RNA, Messenger; D016194:Receptors, N-Methyl-D-Aspartate; D010544:Peroxidases; D051546:Cyclooxygenase 2; D011451:Prostaglandin-Endoperoxide Synthases; D010622:Phencyclidine