A comparison of IgG antibody reactive with Bacteroides forsythus and Porphyromonas gingivalis in adult and early-onset periodontitis.
Recent work has indicated that Bacteroides forsythus and Porphyromonas gingivalis are significant local risk factors for periodontitis. Several reports find that both organisms are frequently associated with periodontitis lesions and often are present together. We have previously shown that early-onset periodontitis patients seropositive for P. gingivalis have less attachment loss than seronegative patients. In this study, we determined serum IgG antibody concentrations reactive with B. forsythus in adult and early-onset periodontitis patients using an ELISA and used P. gingivalis in the same populations as a positive control. The results for P. gingivalis were consistent with previous work and indicated that 47%, 36%, and 33% of adult, generalized early-onset, and localized juvenile patients were seropositive, respectively. Mean serum IgG concentrations for the three groups were 5.36 microg/ml, 5.65 microg/ml, and 5.44 microg/ml for adult, generalized early-onset, and localized juvenile patients, respectively. In contrast, for B. forsythus only 11%, 14%, and 10% of adult, generalized early-onset, and localized juvenile patients were seropositive, with mean serum IgG concentrations of 0.46 microg/ml, 0.46 microg/ml, and 0.47 microg/ml, respectively. This suggests that B. forsythus is either poorly immunogenic or less invasive than P. gingivalis. If most patients fail to mount an immune response to B. forsythus and it is invasive, it may explain why this organism is a risk factor for disease.
Califano
J V
JV
Clinical Research Center for Periodontal Diseases, School of Dentistry, Virginia Commonwealth University, Richmond 23298-0566, USA.
Gunsolley
J C
JC
Schenkein
H A
HA
Tew
J G
JG
D000328:Adult; D010520:Aggressive Periodontitis / Q000276:immunology / Q000382:microbiology*; D000907:Antibodies, Bacterial / Q000096:biosynthesis / Q000097:blood*; D001439:Bacteroides / Q000276:immunology*; D016022:Case-Control Studies; D002908:Chronic Disease; D003367:Cotinine / Q000097:blood; D004797:Enzyme-Linked Immunosorbent Assay; D005888:Gingival Pocket / Q000276:immunology / Q000382:microbiology; D005889:Gingival Recession / Q000276:immunology / Q000382:microbiology; D006801:Humans; D007074:Immunoglobulin G / Q000096:biosynthesis / Q000097:blood*; D008875:Middle Aged; D017622:Periodontal Attachment Loss / Q000276:immunology / Q000382:microbiology; D010518:Periodontitis / Q000276:immunology / Q000382:microbiology*; D016966:Porphyromonas gingivalis / Q000276:immunology*; D012307:Risk Factors; D012907:Smoking / Q000097:blood
D000907:Antibodies, Bacterial; D007074:Immunoglobulin G; D003367:Cotinine