Analysis of the immunoglobulin heavy-chain gene rearrangement providing molecular evidence of second lymphoma in a patient in apparent relapse after autotransplantation.
Development of a second lymphoma after autotransplantation is an unusual event. Its real incidence, however, could be underestimated, since histologic and immunophenotyping techniques are often unable to distinguish it from a relapse. We report a lymphoma patient in apparent relapse after 42 months of molecular remission achieved by autotransplantation. Sequencing analysis of the immunoglobulin heavy-chain genes showed that the rearrangement of variable, diversity and joining segments had changed between diagnosis and relapse and suggested that a second lymphoma had developed.
Campana
S
S
Dipartimento di Medicina ed Oncologia Sperimentale, Azienda Ospedaliera S Giovanni Battista, Torino, Italy.
Corradini
P
P
Astolfi
M
M
Ladetto
M
M
Cinque
F
F
Novero
D
D
Tarella
C
C
Pileri
A
A
D000328:Adult; D001483:Base Sequence; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D002051:Burkitt Lymphoma / Q000175:diagnosis*; D015321:Gene Rearrangement; D005803:Genes, Immunoglobulin; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics*; D008224:Lymphoma, Follicular / Q000628:therapy*; D008297:Male; D008969:Molecular Sequence Data; D016609:Neoplasms, Second Primary / Q000175:diagnosis*; D012008:Recurrence; D014182:Transplantation, Autologous
D007143:Immunoglobulin Heavy Chains