Factor X deficiency in a cat.
Severe congenital deficiency of factor X was diagnosed in a 3-year-old castrated male domestic shorthair cat with clinical signs of generalized seizures and prolonged bleeding after venipuncture. Heritability of factor X deficiency was suspected because of a prolonged Russell's viper venom time in the dam and reductions in factor X activity in the dam and 1 sibling. To our knowledge, factor X deficiency in cats has not been reported previously. Definitive diagnosis for animals with clinical signs of coagulopathy may require repetition of coagulation screening tests using different assay methods or specific coagulation factor analyses.
Gookin
J L
JL
Department of Companion Animal and Special Species Medicine, College of Veterinary Medicine, North Carolina State University, Raleigh 27606, USA.
Brooks
M B
MB
Catalfamo
J L
JL
Bunch
S E
SE
Muñana
K R
KR
D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects / Q000502:physiology; D002371:Cat Diseases / Q000097:blood / Q000175:diagnosis* / Q000188:drug therapy; D002415:Cats; D005170:Factor X / Q000032:analysis; D005171:Factor X Deficiency / Q000097:blood / Q000175:diagnosis / Q000662:veterinary*; D008297:Male; D010314:Partial Thromboplastin Time; D011517:Prothrombin Time; D014812:Vitamin K / Q000032:analysis / Q000494:pharmacology / Q000627:therapeutic use
D014812:Vitamin K; D005170:Factor X