Effect of estradiol metabolites on the susceptibility of low density lipoprotein to oxidation.
The main estradiol metabolites 2-hydroxyestrone, 2-methoxyestrone and 16alpha-hydroxyestrone were investigated in vitro for the susceptibility of low density lipoprotein to oxidation and the effects compared with those of estradiol and vitamin E. 2-hydroxyestrone and 2-methoxyestrone had a greater inhibitory effect than estradiol and vitamin E whereas 16alpha-hydroxyestrone approximates the inhibition of estradiol. These results indicate that 2-hydroxyestrone and 2-methoxyestrone possess non-genomic actions which may play a role in the lipid metabolism.
Seeger
H
H
Department Obstetrics and Gynecology, University Tuebingen, Germany.
Mueck
A O
AO
Lippert
T H
TH
D004958:Estradiol / Q000378:metabolism / Q000494:pharmacology; D002393:Estrogens, Catechol / Q000494:pharmacology*; D006801:Humans; D006894:Hydroxyestrones / Q000494:pharmacology*; D007700:Kinetics; D008077:Lipoproteins, LDL / Q000378:metabolism*; D010084:Oxidation-Reduction; D014810:Vitamin E / Q000494:pharmacology
D002393:Estrogens, Catechol; D006894:Hydroxyestrones; D008077:Lipoproteins, LDL; D014810:Vitamin E; C026702:16-hydroxyestrone; D004958:Estradiol; C003655:2-methoxyestrone; C024980:2-hydroxyestrone