title: The influence of vasculature on temperature distributions in MECS interstitial hyperthermia: importance of longitudinal control.
abstract: The quality of temperature distributions that can be generated with the Multi Electrode Current Source (MECS) interstitial hyperthermia (IHT) system, which allows 3D control of the temperature distribution, has been investigated. For the investigations, computer models of idealised anatomies containing discrete vessels, were used. A 7-catheter hexagonal implant geometry with a nearest neighbour distance of 15 mm was used. In each interstitial catheter with a diameter of 2.1 mm a number of 1 up to 4 electrodes were placed along an 'active section' with a length of 50 mm. The electrode segments had lengths of 50, 20, 12 and 9 mm respectively. Both single vessel and vessel network situations were analysed. This study shows that even in situations with discrete vasculature and perfusion heterogeneity it remains possible to obtain satisfactory temperature distributions with the MECS IHT system. Due to its 3D spatial control the temperature homogeneity in the implant can be made quite satisfactory.
authors.affiliation: University Hospital Utrecht, Department of Radiotherapy, The Netherlands.
authors.forename: J F
authors.initials: JF
authors.lastname: van der Koijk
authors.forename: J J
authors.initials: JJ
authors.lastname: Lagendijk
authors.forename: J
authors.initials: J
authors.lastname: Crezee
authors.forename: J
authors.initials: J
authors.lastname: de Bree
authors.forename: A N
authors.initials: AN
authors.lastname: Kotte
authors.forename: G M
authors.initials: GM
authors.lastname: van Leeuwen
authors.forename: J J
authors.initials: JJ
authors.lastname: Battermann
mesh_terms: D001808:Blood Vessels / Q000033:anatomy & histology / Q000502:physiology; D003198:Computer Simulation; D004566:Electrodes; D005069:Evaluation Studies as Topic; D006801:Humans; D006979:Hyperthermia, Induced / Q000295:instrumentation / Q000379:methods* / Q000706:statistics & numerical data; D008953:Models, Anatomic; D008955:Models, Cardiovascular; D013696:Temperature