title: Placebo-controlled evaluation of a modified life virus vaccine against feline infectious peritonitis: safety and efficacy under field conditions.
abstract: A modified live virus vaccine against feline infectious peritonitis (FIP) was evaluated in a double blind, placebo-controlled field trial in two high-risk populations. The vaccine was found to be safe and efficacious in one population of cats that had low antibody titre against feline coronavirus (FCoV) at the time of vaccination. Although clinically healthy at the time of vaccination, retrospectively some vaccinees that later came down with FIP were found to be RT-PCR positive for FCoV in plasma and showed changes in blood parameters consistent with early stage of FIP. It is concluded that vaccination can protect cats with no or low FCoV antibody titres and that in some cats vaccine failure was probably due to pre-existing infection.
authors.affiliation: Department of Internal Veterinary Medicine, University of Zurich, Switzerland.
authors.forename: D
authors.initials: D
authors.lastname: Fehr
authors.forename: E
authors.initials: E
authors.lastname: Holznagel
authors.forename: S
authors.initials: S
authors.lastname: Bolla
authors.forename: B
authors.initials: B
authors.lastname: Hauser
authors.forename: A A
authors.initials: AA
authors.lastname: Herrewegh
authors.forename: M C
authors.initials: MC
authors.lastname: Horzinek
authors.forename: H
authors.initials: H
authors.lastname: Lutz
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D002415:Cats; D016765:Coronavirus, Feline / Q000235:genetics / Q000276:immunology* / Q000302:isolation & purification; D004311:Double-Blind Method; D016766:Feline Infectious Peritonitis / Q000276:immunology / Q000517:prevention & control* / Q000821:virology; D005260:Female; D008297:Male; D016133:Polymerase Chain Reaction; D012449:Safety; D014765:Viral Vaccines / Q000009:adverse effects / Q000494:pharmacology*; D014766:Viremia / Q000517:prevention & control
chemical_list: D000914:Antibodies, Viral; D014765:Viral Vaccines