Effect of isosorbide on distortion-product otoacoustic emissions and endocochlear DC potential in experimentally induced hydropic ears.
The effects of isosorbide on distortion-product otoacoustic emissions (DPOAEs) and endocochlear DC potential (EP) were examined in experimentally induced endolymphatic hydropic ears and untreated control ears using 20 albino guinea pigs. DPOAEs and EP in the hydropic ears decreased after obliteration of the endolymphatic duct and sac. The administration of isosorbide restored DPOAEs to the normal level, whereas EP was further reduced. In control ears there was no significant change in DPOAEs and EP after the administration of isosorbide. The results obtained in the present study indicate that the effect of isosorbide on DPOAEs is different from that on EP, and the recovery of DPOAEs in hydropic ears is not a secondary phenomenon due to the recovery of EP.
Okubo
H
H
Department of Otolaryngology, University of Tsukuba, Japan.
Tachihara
N
N
Satoh
S
S
Hara
A
A
Kusakari
J
J
D000161:Acoustic Stimulation; D000200:Action Potentials / Q000187:drug effects / Q000502:physiology; D000818:Animals; D001307:Auditory Perception / Q000187:drug effects* / Q000502:physiology; D003051:Cochlea / Q000187:drug effects* / Q000503:physiopathology; D004234:Diuretics, Osmotic / Q000494:pharmacology*; D004711:Endolymphatic Duct / Q000187:drug effects / Q000503:physiopathology; D018159:Endolymphatic Hydrops / Q000188:drug therapy / Q000503:physiopathology*; D004712:Endolymphatic Sac / Q000187:drug effects / Q000503:physiopathology; D005072:Evoked Potentials, Auditory / Q000187:drug effects* / Q000502:physiology; D005260:Female; D006168:Guinea Pigs; D007547:Isosorbide / Q000494:pharmacology*
D004234:Diuretics, Osmotic; D007547:Isosorbide