Liver involvement and its course in experimental colitis in rats.
OBJECTIVE
The aim of the study was to evaluate histological liver lesions and to compare these with the results of biochemical parametres.


METHODS
An experimental model of chronic ulcerative colitis in rats was utilized.


RESULTS
Histological studies of the biliary tree showed progressive fibrotic inflammation which fulfilled the criteria of early sclerosing cholangitis. The biochemical tests of liver function were, however normal in all animals.


CONCLUSIONS
Sclerosing cholangitis in experimental ulcerative colitis is a progressive disease, and normal liver biochemistry does not exclude changes in liver histology.
Wojczys
R
R
1st Department of Surgery, University of Medicine, Wroclaw, Poland.
D000818:Animals; D015209:Cholangitis, Sclerosing / Q000209:etiology / Q000378:metabolism / Q000473:pathology; D002908:Chronic Disease; D003093:Colitis, Ulcerative / Q000150:complications / Q000473:pathology*; D004195:Disease Models, Animal; D018450:Disease Progression; D005500:Follow-Up Studies; D008099:Liver / Q000378:metabolism / Q000473:pathology*; D008111:Liver Function Tests; D008297:Male; D051381:Rats; D011915:Rats, Inbred BUF