title: A case of pyoderma gangrenosum stabilized with lymecycline, topical benzoyl peroxide and treated by autograft.
abstract: Pyoderma gangrenosum is a chronic inflammatory ulcerative skin disease of unknown etiology, often associated with various systemic disorders such as inflammatory bowel disease, rheumatoid arthritis, chronic active hepatitis, diabetes mellitus and hematologic malignancies. The ulcers are characterized by their undermined violaceous borders. The disease remains a therapeutic challenge. Corticosteroids are the mainstay of therapy; however, side effects from this treatment and recalcitrant pyoderma gangrenosum require therapeutic alternatives. We report the case of a large subacute pyoderma gangrenosum stabilized with lymecycline, topical benzoyl peroxide and successfully treated by an autograft. This observation supports the opinion that the risk of pathergy of a graft can be avoided by the stabilization of the disease.
authors.affiliation: Department of Dermatology, Erasme Hospital, Brussels, Belgium.
authors.forename: P
authors.initials: P
authors.lastname: Vereecken
authors.forename: J C
authors.initials: JC
authors.lastname: Wautrecht
authors.forename: G
authors.initials: G
authors.lastname: De Dobbeleer
authors.forename: M
authors.initials: M
authors.lastname: Heenen
mesh_terms: D000208:Acute Disease; D000279:Administration, Cutaneous; D000305:Adrenal Cortex Hormones / Q000009:adverse effects / Q000627:therapeutic use; D000368:Aged; D000369:Aged, 80 and over; D000740:Anemia / Q000150:complications; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001585:Benzoyl Peroxide / Q000008:administration & dosage / Q000627:therapeutic use*; D003111:Colonic Polyps / Q000150:complications; D048909:Diabetes Complications; D005260:Female; D006085:Graft Survival; D006801:Humans; D007417:Intestinal Polyps / Q000150:complications; D007641:Keratolytic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D008194:Lymecycline / Q000008:administration & dosage / Q000627:therapeutic use*; D017511:Pyoderma Gangrenosum / Q000188:drug therapy* / Q000473:pathology; D012004:Rectal Neoplasms / Q000150:complications; D016038:Skin Transplantation; D013276:Stomach Ulcer / Q000150:complications; D014182:Transplantation, Autologous
chemical_list: D000305:Adrenal Cortex Hormones; D000900:Anti-Bacterial Agents; D007641:Keratolytic Agents; D008194:Lymecycline; D001585:Benzoyl Peroxide