title: Interaction of vitamins E and K: effect of high dietary vitamin E on phylloquinone activity in chicks.
abstract: To determine the influence of vitamin E on phylloquinone activity, one day-old chicks were raised on a masch diet supplemented with different amounts of vitamin E for 31 days. In chicks fed a diet high in vitamin E (4000 mg allrac-alpha-tocopheryl acetate/kg) but adequate in vitamin K (0.14 mg phylloquinone/kg) a threefold increase in prothrombin time and an increase in mortality rate (five out of twelve animals died from increased bleeding tendency) was observed. The inhibiting effect of high dietary vitamin E on procoagulant factors could be prevented by increasing dietary phylloquinone supplementation. Weight development, and feed utilization were insignificantly different in chicks fed different amounts and ratios of vitamins E and K1. Plasma and liver alpha-tocopherol levels correlated with dietary amounts of vitamin E. Increased phylloquinone levels in the diet did not significantly influence alpha-tocopherol concentrations in plasma and liver, but coagulopathy caused by high vitamin E intake could be reversed.
authors.affiliation: Department of Biological Chemistry and Nutrition, Universität Hohenheim, Stuttgart, Germany.
authors.forename: J
authors.initials: J
authors.lastname: Frank
authors.forename: H
authors.initials: H
authors.lastname: Weiser
authors.forename: H K
authors.initials: HK
authors.lastname: Biesalski
mesh_terms: D000818:Animals; D001778:Blood Coagulation Disorders / Q000139:chemically induced / Q000517:prevention & control; D002645:Chickens; D004032:Diet; D005260:Female; D008099:Liver / Q000378:metabolism; D011517:Prothrombin Time; D014810:Vitamin E / Q000008:administration & dosage / Q000009:adverse effects / Q000097:blood / Q000378:metabolism / Q000494:pharmacology*; D014812:Vitamin K / Q000008:administration & dosage / Q000494:pharmacology*; D010837:Vitamin K 1 / Q000008:administration & dosage / Q000494:pharmacology*; D015430:Weight Gain
chemical_list: D014812:Vitamin K; D014810:Vitamin E; D010837:Vitamin K 1