title: N-type calcium channel blockers from a marine bacterium, Cytophaga sp. SANK 71996.
abstract: N-(3-Acyloxyacyl)glycines were isolated as N-type calcium channel blockers from a marine bacterium Cytophaga sp. SANK 71996. The identification and fermentation of the producing strain and structure characterization of N-(3-acyloxyacyl)glycines by spectral analyses and chemical syntheses are described together with their antagonistic activities.
authors.affiliation: Biomedical Research Laboratories, Sankyo Co., Ltd., Tokyo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Morishita
authors.forename: A
authors.initials: A
authors.lastname: Sato
authors.forename: M
authors.initials: M
authors.lastname: Hisamoto
authors.forename: T
authors.initials: T
authors.lastname: Oda
authors.forename: K
authors.initials: K
authors.lastname: Matsuda
authors.forename: A
authors.initials: A
authors.lastname: Ishii
authors.forename: K
authors.initials: K
authors.lastname: Kodama
mesh_terms: D000818:Animals; D002121:Calcium Channel Blockers / Q000302:isolation & purification / Q000378:metabolism* / Q000494:pharmacology*; D015220:Calcium Channels / Q000187:drug effects*; D003589:Cytophaga / Q000737:chemistry* / Q000145:classification / Q000378:metabolism*; D005285:Fermentation; D005998:Glycine / Q000096:biosynthesis* / Q000302:isolation & purification / Q000494:pharmacology*; D011817:Rabbits; D013329:Structure-Activity Relationship
chemical_list: D002121:Calcium Channel Blockers; D015220:Calcium Channels; D005998:Glycine