Cancer incidence among an HIV-infected cohort. Pulmonary Complications of HIV Infection Study Group.
Malignancies, particularly Kaposi's sarcoma and non-Hodgkin's lymphoma (NHL), are associated with human immunodeficiency virus (HIV) infection. Cancer incidence among 1,073 asymptomatic HIV-infected individuals from the Pulmonary Complications of HIV Infection Study cohort, persons from six states followed from 1988 to 1994, was examined. Total cancer incidence was 3.99/100 person-years; for Kaposi's sarcoma, incidence was 2.64 cases/100 person-years, and for NHL, it was 1.18 cases/100 person-years. Total cancer (n = 156 cases) was higher among nonblacks than among blacks (rate ratio = 2.8, 95% confidence interval 1.3-6.1), with similar results for Kaposi's sarcoma and NHL. The rate of lung cancer (n = 5) among white, homosexual/bisexual males was 0.18 per 100 person-years, suggesting a high risk of lung cancer.
Johnson
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CC
Henry Ford Health Sciences Center, Division of Biostatistics and Research Epidemiology, Detroit, MI 48202, USA.
Wilcosky
T
T
Kvale
P
P
Rosen
M
M
Stansell
J
J
Glassroth
J
J
Reichman
L
L
Wallace
J
J
Markowitz
N
N
Thompson
J E
JE
Hopewell
P
P
D000328:Adult; D015331:Cohort Studies; D005260:Female; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D015994:Incidence; D016483:Lymphoma, AIDS-Related / Q000453:epidemiology* / Q000821:virology; D008228:Lymphoma, Non-Hodgkin / Q000453:epidemiology* / Q000821:virology; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000453:epidemiology* / Q000821:virology; D016017:Odds Ratio; D012514:Sarcoma, Kaposi / Q000453:epidemiology* / Q000821:virology