The relationship of smooth muscle damage to age, severity of pre-operative hydronephrosis and post-operative outcome in obstructive uropathies.
OBJECTIVE
To determine the relationship, in patients with pelvi-ureteric junction (PUJ) obstruction, of histopathological abnormalities to their age at surgery, the severity of pre-operative hydronephrosis and the post-operative outcome.


METHODS
Surgical specimens from 60 consecutive PUJ complexes excised at pyeloplasty were evaluated histologically.


RESULTS
There was a close relationship of smooth muscle abnormality and fibrosis with the severity of pre-operative hydronephrosis and post-operative outcome, with no significant correlation between histopathological abnormality and patient age.


CONCLUSIONS
This study appears to support the practice of the initial non-operative management of congenital PUJ obstruction, potentially reducing the number of early and/or unnecessary interventions. Further investigations and research are necessary to direct appropriate management.
Pintér
A B
AB
Department of Paediatrics, Medical University of Pécs, Hungary.
Horváth
A
A
Hrabovszky
Z
Z
D000293:Adolescent; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D005260:Female; D005355:Fibrosis; D006801:Humans; D006869:Hydronephrosis / Q000473:pathology* / Q000601:surgery; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009130:Muscle, Smooth / Q000473:pathology*; D009133:Muscular Atrophy / Q000473:pathology; D009135:Muscular Diseases / Q000473:pathology; D011182:Postoperative Care; D011300:Preoperative Care; D016896:Treatment Outcome; D014517:Ureteral Obstruction / Q000151:congenital / Q000473:pathology* / Q000601:surgery