Studies of apolipoprotein B-100 metabolism using radiotracers and stable isotopes.
Apolipoprotein B metabolism can be investigated in-vivo either by exogenous radiolabeling of preformed lipoproteins or by endogenous labelling of denovo synthesized apo B using a stable isotope substituted amino acid tracer. The potential of both methods and results obtained by in-vivo studies in genetically determined dys- or hyperlipidaemic subjects will be discussed.
Demant
T
T
Institut für Klinische Chemie, Klinikum Grosshadern, München, Germany.
Packard
C J
CJ
D053299:Apolipoprotein B-100; D001055:Apolipoproteins B / Q000378:metabolism*; D003903:Deuterium; D006801:Humans; D006949:Hyperlipidemias / Q000378:metabolism*; D007457:Iodine Radioisotopes; D007553:Isotope Labeling / Q000379:methods*; D008074:Lipoproteins / Q000378:metabolism*
D053299:Apolipoprotein B-100; D001055:Apolipoproteins B; D007457:Iodine Radioisotopes; D008074:Lipoproteins; D003903:Deuterium