[Endogenous digitalis-like factor].
Evidence suggests the existence of a Na,K-ATPase inhibitor, so called endogenous digitalis-like factor (EDLF), in plasma. This substance has been postulated to enhance renal tubular sodium excretion and to increase peripheral vascular resistance. Recently, plant ouabain or its isomer (ouabain-like compound, OLC) was purified from human plasma and bovine hypothalamic extract. The OLC is considered to be a candidate for the EDLF. The OLC has been implicated in the pathogenesis of sodium-dependent hypertension. Furthermore, accumulating evidence suggests central nervous system as a site of hypertensinogenic action of OLC.
Yamazato
M
M
Third Department of Internal Medicine, University of the Ryukyus School of Medicine.
Muratani
H
H
Fukiyama
K
K
D000818:Animals; D001685:Biological Factors / Q000502:physiology*; D002298:Cardenolides; D002417:Cattle; D002490:Central Nervous System / Q000502:physiology; D004077:Digoxin; D006801:Humans; D006973:Hypertension / Q000209:etiology*; D012503:Saponins; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors
D001685:Biological Factors; D002298:Cardenolides; D012503:Saponins; C034504:digoxin-like factors; D004077:Digoxin; D000254:Sodium-Potassium-Exchanging ATPase