title: Adhesion and growth of Serratia marcescens on artificial closed eye tears soaked hydrogel contact lenses.
abstract: The adhesion to hydrogel contact lenses and growth of Serratia marcescens on artificial tear fluid (ATF) soaked lenses was investigated. Results indicated that a corneal ulcer isolate adhered more avidly to lenses; ATF increased adhesion for all strains tested. The contact lens induced acute red eye (CLARE) isolate adhered poorly, however, it grew to a larger extent on ATF-coated lenses. The ability of the corneal ulcer isolate to adhere to lenses may be an important factor in its pathogenicity whereas the ability of the CLARE isolate to grow on the lens in the presence of antimicrobial tear proteins may be important in the development of inflammation.
authors.affiliation: Cooperative Research Centre for Eye Research and Technology, University of New South Wales, Sydney, Australia.
authors.forename: E B
authors.initials: EB
authors.lastname: Hume
authors.forename: M D
authors.initials: MD
authors.lastname: Willcox
mesh_terms: D001422:Bacterial Adhesion / Q000502:physiology*; D015169:Colony Count, Microbial; D003263:Contact Lenses, Hydrophilic; D003320:Corneal Ulcer / Q000382:microbiology; D006801:Humans; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D009883:Ophthalmic Solutions / Q000378:metabolism*; D011092:Polyethylene Glycols; D012706:Serratia marcescens / Q000302:isolation & purification / Q000502:physiology*
chemical_list: D009883:Ophthalmic Solutions; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D011092:Polyethylene Glycols