title: eyelid antagonizes wingless signaling during Drosophila development and has homology to the Bright family of DNA-binding proteins.
abstract: In Drosophila, pattern formation at multiple stages of embryonic and imaginal development depends on the same intercellular signaling pathways. We have identified a novel gene, eyelid (eld), which is required for embryonic segmentation, development of the notum and wing margin, and photoreceptor differentiation. In these tissues, eld mutations have effects opposite to those caused by wingless (wg) mutations. eld encodes a widely expressed nuclear protein with a region homologous to a novel family of DNA-binding domains. Based on this homology and on the phenotypic analysis, we suggest that Eld could act as a transcription factor antagonistic to the Wg pathway.
authors.affiliation: Skirball Institute of Biomolecular Medicine, NYU Medical Center, New York, New York 10016, USA. treisman@saturn.med.nyu.edu
authors.forename: J E
authors.initials: JE
authors.lastname: Treisman
authors.forename: A
authors.initials: A
authors.lastname: Luk
authors.forename: G M
authors.initials: GM
authors.lastname: Rubin
authors.forename: U
authors.initials: U
authors.lastname: Heberlein
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D019521:Body Patterning / Q000235:genetics; D002454:Cell Differentiation; D003001:Cloning, Molecular; D004268:DNA-Binding Proteins / Q000032:analysis / Q000235:genetics* / Q000502:physiology; D004330:Drosophila / Q000196:embryology* / Q000235:genetics / Q000254:growth & development; D029721:Drosophila Proteins; D018507:Gene Expression Regulation, Developmental; D017344:Genes, Insect / Q000235:genetics; D008969:Molecular Sequence Data; D009154:Mutation; D010641:Phenotype; D017956:Photoreceptor Cells, Invertebrate / Q000737:chemistry / Q000166:cytology / Q000254:growth & development; D011518:Proto-Oncogene Proteins / Q000502:physiology*; D011993:Recombinant Fusion Proteins; D015183:Restriction Mapping; D017386:Sequence Homology, Amino Acid; D015398:Signal Transduction / Q000502:physiology*; D015534:Trans-Activators / Q000235:genetics*; D014157:Transcription Factors / Q000032:analysis / Q000235:genetics* / Q000502:physiology; D014921:Wings, Animal / Q000254:growth & development; D051155:Wnt1 Protein
chemical_list: D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; D011518:Proto-Oncogene Proteins; D011993:Recombinant Fusion Proteins; D015534:Trans-Activators; D014157:Transcription Factors; D051155:Wnt1 Protein; C117995:osa protein, Drosophila; C074622:wg protein, Drosophila