The trans-Golgi network: a late secretory sorting station.
Proteins synthesized on membrane-bound ribosomes are transported through the Golgi apparatus and, on reaching the trans-Golgi network, are sorted for delivery to various cellular destinations. Sorting involves the assembly of cytosol-oriented coat structures which preferentially package cargo into vesicular transport intermediates. Recent studies have shed new light on both the molecular machinery involved and the complexity of the sorting processes.
Traub
L M
LM
Division of Hematology, Washington University School of Medicine, St Louis, MO 63110, USA.
Kornfeld
S
S
D000818:Animals; D002462:Cell Membrane / Q000502:physiology; D002966:Clathrin / Q000502:physiology; D003600:Cytosol / Q000378:metabolism; D011992:Endosomes / Q000502:physiology; D006056:Golgi Apparatus / Q000502:physiology*; D006706:Homeostasis; D008954:Models, Biological; D014176:Protein Biosynthesis; D011499:Protein Processing, Post-Translational; D011506:Proteins / Q000378:metabolism*; D012270:Ribosomes / Q000378:metabolism
D002966:Clathrin; D011506:Proteins