Current limitations to protein threading approaches.
A short review of the threading approach to protein structure prediction, including presentation of some open statistical problems. Also discussed is one of the likely sources of the current limited success, that being the form of the pairwise potentials used in most threading approaches.
Smith
T F
TF
BioMolecular Engineering Research Center, College of Engineering, Boston University, Massachusetts 02215, USA. tsmith@darwin.bu.edu
Lo Conte
L
L
Bienkowska
J
J
Gaitatzes
C
C
Rogers
R G
RG
Lathrop
R
R
D008956:Models, Chemical; D008958:Models, Molecular; D015233:Models, Statistical; D011487:Protein Conformation