title: A microgranular variant of acute promyelocytic leukemia with atypical morpho-cytochemical features and an early myeloid immunophenotype.
abstract: This report describes a unique case of acute promyelocytic leukemia (APL) showing elusive morphologic features, an atypical pattern of cytochemical reactions, and a previously unreported immunophenotype consistent with a very early myeloid form: CD13 (+), CD33 (+), CD9 (+), CD2 (+), HLA-DR (-), CD34 (+), CD117 (+), and TdT (+). The diagnosis of AML M3 variant was made only after genotypic analyses revealed the PML/RAR alpha rearrangement associated with the typical (15;17) (q22;q21) translocation. This example of 'asynchronous differentiation' emphasizes the need for a multiparameter approach to the diagnosis of acute leukemia.
authors.affiliation: Chair of Hematology, University of Rome Tor Vergata, S. Eugenio Hospital, Italy. mc2558@mclink.it
authors.forename: R
authors.initials: R
authors.lastname: Stasi
authors.forename: A
authors.initials: A
authors.lastname: Bruno
authors.forename: A
authors.initials: A
authors.lastname: Venditti
authors.forename: G
authors.initials: G
authors.lastname: Del Poeta
authors.forename: G
authors.initials: G
authors.lastname: Aronica
authors.forename: M C
authors.initials: MC
authors.lastname: Cox
authors.forename: L
authors.initials: L
authors.lastname: Maffei
authors.forename: G
authors.initials: G
authors.lastname: Catalano
authors.forename: D
authors.initials: D
authors.lastname: Zangrilli
authors.forename: S
authors.initials: S
authors.lastname: Amadori
mesh_terms: D000328:Adult; D015703:Antigens, CD / Q000276:immunology; D002869:Chromosome Aberrations; D006651:Histocytochemistry; D006801:Humans; D016130:Immunophenotyping; D017404:In Situ Hybridization, Fluorescence; D015473:Leukemia, Promyelocytic, Acute / Q000235:genetics / Q000276:immunology / Q000473:pathology*; D008297:Male
chemical_list: D015703:Antigens, CD