DNA-protein cross-links in leukocytes of mice induced by Zn, Cd, and Pb.
A single subdermal injection of CdCl2 or Pb(CH3COO)2 results, together with remarkable changes in the blood cell pattern, in increased DNA-protein cross-links in mouse leukocytes in 24 h; after 15 days the DNA-protein cross-linking returned to the initial level. In contrast, after injection of ZnSO4 a high level of DNA-protein cross-links is retained during the whole observation period (15 days). In the studied range of doses the formation of DNA-protein cross-links is proportional to the logarithm of the dose.
Osipov
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AN
United Ecological-Technological and Research Center on Neutralization of Radioactive Waste and Environmental Protection (MosNPO Radon), Moscow, Russia.
Sypin
V D
VD
Kolomijtseva GYa
Polsky
O G
OG
Ilyinov
A N
AN
D000818:Animals; D001798:Blood Proteins / Q000737:chemistry* / Q000187:drug effects*; D019256:Cadmium Chloride / Q000008:administration & dosage / Q000633:toxicity*; D003432:Cross-Linking Reagents; D004247:DNA / Q000097:blood / Q000737:chemistry* / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D007962:Leukocytes / Q000737:chemistry / Q000187:drug effects; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009942:Organometallic Compounds / Q000008:administration & dosage / Q000633:toxicity*; D019287:Zinc Sulfate / Q000008:administration & dosage / Q000633:toxicity*
D001798:Blood Proteins; D003432:Cross-Linking Reagents; D009942:Organometallic Compounds; D019287:Zinc Sulfate; D004247:DNA; D019256:Cadmium Chloride; C008261:lead acetate