title: Cytogenetic effects of the herbicide chloridazon in cultured sheep lymphocytes.
abstract: The effect of in vitro exposure to the herbicide chloridazon on the induction of chromosome aberrations (CA) and sister chromatid exchanges (SCE) was studied in cultured sheep peripheral lymphocytes. A positive clastogenic effect was observed in chloridazon-treated cultures at a dose of 7 x 10(-4) M both in the presence and absence of the S9 fraction, but no significant increase of chromosome breaks was seen at lower doses (7 x 10(-6) M and 7 x 10(-5) M, respectively). A clear dose-dependence and significant differences were found in chloridazon potency to induce SCEs. Induction of cell cycle delays as compared to the controls was not observed.
authors.affiliation: Department of Veterinary Genetics, University of Veterinary Medicine, Kosice, Slovak Republic.
authors.forename: K
authors.initials: K
authors.lastname: Siviková
authors.forename: J
authors.initials: J
authors.lastname: Dianovský
mesh_terms: D000818:Animals; D002869:Chromosome Aberrations; D004305:Dose-Response Relationship, Drug; D006540:Herbicides / Q000009:adverse effects*; D066298:In Vitro Techniques; D008214:Lymphocytes / Q000166:cytology / Q000187:drug effects; D011724:Pyridazines / Q000009:adverse effects*; D012756:Sheep; D012854:Sister Chromatid Exchange
chemical_list: D006540:Herbicides; D011724:Pyridazines; C005586:pyrazon