title: Hodgkin's cells express CD83, a dendritic cell lineage associated antigen.
abstract: Hodgkin's cells (HC) are considered to be the malignant cells of Hodgkin's disease (HD), but despite extensive studies, no conclusive evidence has emerged regarding their non-malignant counterpart and the ontogeny of these cells remains controversial. The analysis of a possible dendritic cell (DC) origin of HC has been hampered to date by the lack of a DC lineage specific marker. The expression of the two DC-associated antigens CD83 and CMRF-44, the B lymphocyte restricted molecule CD79, and the costimulator molecule CD86, was examined in lymph nodes from 23 HD patients using immunohistological techniques. The majority of HC expressed the CD83 (22/23) and CD86 antigens (20/23), whereas expression of the CMRF-44 antigen was variable (10/23) and usually only a subpopulation of HC stained. In contrast, the CD79 antigen was absent from most HC (17/23). The presence of the CD83 antigen on HC in the absence of the CD79 antigen supports a possible DC lineage origin for some HC. Regardless of its role in lineage assignment, CD83 may become a useful immunohistological marker for HD as the CD83 antigen was present on most HC.
authors.affiliation: Department of Anatomical Pathology, Christchurch Hospital, New Zealand.
authors.forename: U R
authors.initials: UR
authors.lastname: Sorg
authors.forename: T M
authors.initials: TM
authors.lastname: Morse
authors.forename: W N
authors.initials: WN
authors.lastname: Patton
authors.forename: B D
authors.initials: BD
authors.lastname: Hock
authors.forename: H B
authors.initials: HB
authors.lastname: Angus
authors.forename: B A
authors.initials: BA
authors.lastname: Robinson
authors.forename: B M
authors.initials: BM
authors.lastname: Colls
authors.forename: D N
authors.initials: DN
authors.lastname: Hart
mesh_terms: D000911:Antibodies, Monoclonal; D015703:Antigens, CD / Q000032:analysis*; D019070:Cell Lineage; D003713:Dendritic Cells / Q000276:immunology*; D006689:Hodgkin Disease / Q000276:immunology / Q000473:pathology*; D006801:Humans; D007124:Immunoenzyme Techniques; D007136:Immunoglobulins / Q000032:analysis*; D016130:Immunophenotyping; D008562:Membrane Glycoproteins / Q000032:analysis*; D000097802:CD83 Antigen
chemical_list: D000911:Antibodies, Monoclonal; D015703:Antigens, CD; D007136:Immunoglobulins; D008562:Membrane Glycoproteins; D000097802:CD83 Antigen