title: Multiorgan system failure caused by valproic acid toxicity.
abstract: Valproic acid is an effective antiseizure medication that is also used for other indications such as migraine prophylaxis. It is known to sometimes cause hepatic injury, both a mild dose-related form and an idiosyncratic, fulminant, usually fatal type. A case is reported of multiorgan failure caused by valproic acid toxicity in an adult who survived. Such multisystem toxicity has not been previously reported.
authors.affiliation: Department of Emergency Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
authors.forename: R
authors.initials: R
authors.lastname: Pinkston
authors.forename: L A
authors.initials: LA
authors.lastname: Walker
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced; D000927:Anticonvulsants / Q000506:poisoning* / Q000627:therapeutic use; D004630:Emergencies; D006801:Humans; D017093:Liver Failure / Q000139:chemically induced; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000188:drug therapy; D009102:Multiple Organ Failure / Q000139:chemically induced*; D010195:Pancreatitis / Q000139:chemically induced; D012206:Rhabdomyolysis / Q000139:chemically induced; D014635:Valproic Acid / Q000506:poisoning* / Q000627:therapeutic use
chemical_list: D000927:Anticonvulsants; D014635:Valproic Acid