Blocking of the B7-CD28 pathway increases the capacity of FasL+ (CD95L+) dendritic cells to kill alloactivated T cells.
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Thomas E. Starzl Transplantation Institute, University of Pittsburgh, Pennsylvania 15213, USA.
Qian
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Starzl
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Lynch
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Thomson
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D000818:Animals; D015703:Antigens, CD / Q000378:metabolism; D017209:Apoptosis; D018122:B7-1 Antigen / Q000378:metabolism; D051940:B7-2 Antigen; D001854:Bone Marrow Cells / Q000276:immunology; D018106:CD28 Antigens / Q000378:metabolism; D003001:Cloning, Molecular; D003602:Cytotoxicity, Immunologic; D053938:DNA Fragmentation; D018076:DNA, Complementary / Q000235:genetics; D003713:Dendritic Cells / Q000276:immunology*; D053222:Fas Ligand Protein; D006801:Humans; D066298:In Vitro Techniques; D007519:Isoantigens; D019169:Jurkat Cells; D008213:Lymphocyte Activation; D007959:Lymphocyte Culture Test, Mixed; D008297:Male; D008562:Membrane Glycoproteins / Q000235:genetics / Q000378:metabolism*; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology* / Q000378:metabolism; D019014:fas Receptor / Q000378:metabolism
D015703:Antigens, CD; D018122:B7-1 Antigen; D051940:B7-2 Antigen; D018106:CD28 Antigens; C497964:CD86 protein, human; C497965:Cd86 protein, mouse; D018076:DNA, Complementary; C505661:FASLG protein, human; D053222:Fas Ligand Protein; C505658:Fasl protein, mouse; D007519:Isoantigens; D008562:Membrane Glycoproteins; D019014:fas Receptor