title: A comparison of preoperative morphine and buprenorphine for postoperative analgesia for arthrotomy in dogs.
abstract: The aim of this study was to compare morphine with the partial agonist, buprenorphine, for postoperative analgesic effects, when administered preoperatively for elective arthrotomy in dogs. Fifty two dogs were anaesthetized for stifle, elbow, or hock arthrotomy. The dogs were premedicated 30 min prior to induction of anaesthesia with 0.03 mg/kg acepromazine intramuscularly, and either 0.3 mg/kg morphine or 0.01 mg/kg buprenorphine intramuscularly (allocated randomly). Anaesthesia was induced with thiopentone and maintained with halothane in an oxygen/nitrous oxide mixture. Pain and sedation were assessed preoperatively, and 0.5, 1, 2, 3, 5, and 7 h after the halothane was switched off, with a visual analogue scale scoring system. Pain scores did not differ significantly (morphine group median postoperative score from 30 to 40 mm, buprenophine group median postoperative score from 36 to 43 mm) and analgesia was considered adequate in the majority of cases (score less than 40 mm). Morphine produced significantly more sedation at 0.5 h after anaesthesia only. It was concluded that both opioids are equally suitable analgesics for postoperative analgesia for the elective arthrotomy in dogs.
authors.affiliation: Department of Clinical Veterinary Medicine, Cambridge University, UK.
authors.forename: D C
authors.initials: DC
authors.lastname: Brodbelt
authors.forename: P M
authors.initials: PM
authors.lastname: Taylor
authors.forename: G W
authors.initials: GW
authors.lastname: Stanway
mesh_terms: D000698:Analgesia / Q000662:veterinary*; D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000627:therapeutic use*; D000758:Anesthesia / Q000662:veterinary; D000818:Animals; D002047:Buprenorphine / Q000008:administration & dosage / Q000627:therapeutic use*; D004285:Dogs; D017558:Elective Surgical Procedures / Q000662:veterinary; D005260:Female; D008297:Male; D009020:Morphine / Q000008:administration & dosage / Q000627:therapeutic use*; D009985:Orthopedics / Q000662:veterinary*; D010149:Postoperative Pain / Q000517:prevention & control*; D011229:Preanesthetic Medication
chemical_list: D000701:Analgesics, Opioid; D002047:Buprenorphine; D009020:Morphine