Dihydrophencomycin methyl ester, a new phenazine derivative from a marine Streptomycete.
The novel 5,10-dihydrophencomycin methyl ester (4) and the known microbial metabolites (2-hydroxyphenyl)-acetamide (1), menaquinone MK9 (II, III, VIII, IX-H8) (2), and phencomycin (3a) were isolated from an unidentified marine Streptomyces sp. and the structures were elucidated by NMR methods. Compound 4 shows weak antibiotic activity against Escherichia coli and Bacillus subtilis.
Pusecker
K
K
Department of Organic Chemistry, University of Göttingen, Germany.
Laatsch
H
H
Helmke
E
E
Weyland
H
H
D000083:Acetanilides / Q000302:isolation & purification; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001412:Bacillus subtilis / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D005285:Fermentation; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D010619:Phenazines / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D013302:Streptomyces / Q000737:chemistry* / Q000378:metabolism; D014812:Vitamin K / Q000031:analogs & derivatives / Q000302:isolation & purification; D024482:Vitamin K 2 / Q000031:analogs & derivatives*
C107807:5,10-dihydrophencomycin methyl ester; D000083:Acetanilides; D000900:Anti-Bacterial Agents; D010619:Phenazines; C097854:phencomycin; D024482:Vitamin K 2; D014812:Vitamin K; C047799:2-hydroxyacetanilide; C073355:menaquinone 9