Distinct and specific functions of cGMP-dependent protein kinases.
cGMP-dependent protein kinases I and II conduct signals from widespread signaling systems. Whereas the type I kinase mediates numerous effects of natriuretic peptides and nitric oxide in cardiovascular cells, the type II kinase transduces signals from the Escherichia coli heat-stable enterotoxin, STa, and from the endogenous intestinal peptide, guanylin, stimulating Cl- conductance of the cystic fibrosis transmembrane conductance regulator (CFTR). Although the two kinases may be interchangeable for several functions, CFTR regulation specifically requires the type II kinase.
Lohmann
S M
SM
University of Würzburg, Germany. slohmann@klin-biochem
Vaandrager
A B
AB
Smolenski
A
A
Walter
U
U
De Jonge
H R
HR
D000595:Amino Acid Sequence; D000818:Animals; D006152:Cyclic GMP / Q000378:metabolism; D017869:Cyclic GMP-Dependent Protein Kinases / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D015971:Gene Expression Regulation, Enzymologic; D006801:Humans; D015398:Signal Transduction; D013045:Species Specificity
D017869:Cyclic GMP-Dependent Protein Kinases; D006152:Cyclic GMP