Epstein-Barr virus binding to CD21 activates the initial viral promoter via NF-kappaB induction.
Epstein-Barr virus (EBV), an oncogenic human herpesvirus, binds to and infects normal human B lymphocytes via CD21, the CR2 complement receptor. Studies of the mechanisms that enable EBV to infect nonactivated, noncycling B cells provide compelling evidence for a sequence of events in which EBV binding to CD21 on purified resting human B cells rapidly activates the NF-kappaB transcription factor, which, in turn, binds to and mediates transcriptional activation of Wp, the initial viral latent gene promoter. Thus, EBV binding to its cellular receptor on resting B cells triggers an NF-kappaB-dependent intracellular signaling pathway which is required for infection.
Sugano
N
N
Scripps Research Institute, Department of Immunology, La Jolla, California 92037, USA.
Chen
W
W
Roberts
M L
ML
Cooper
N R
NR
D001241:Aspirin / Q000494:pharmacology; D001402:B-Lymphocytes / Q000276:immunology / Q000821:virology*; D015342:DNA Probes; D004268:DNA-Binding Proteins / Q000032:analysis / Q000235:genetics / Q000378:metabolism; D019309:Epstein-Barr Virus Nuclear Antigens / Q000235:genetics; D015967:Gene Expression Regulation, Viral; D017930:Genes, Reporter; D005814:Genes, Viral; D004854:Herpesvirus 4, Human / Q000378:metabolism*; D006801:Humans; D016328:NF-kappa B / Q000235:genetics / Q000378:metabolism*; D009281:Naphthalenes / Q000494:pharmacology; D011401:Promoter Regions, Genetic; D011518:Proto-Oncogene Proteins / Q000378:metabolism; D012333:RNA, Messenger / Q000032:analysis; D017464:Receptors, Complement 3d / Q000378:metabolism*; D011991:Receptors, Virus / Q000378:metabolism*; D015398:Signal Transduction; D051841:Transcription Factor RelB; D014157:Transcription Factors; D015533:Transcriptional Activation / Q000187:drug effects
D015342:DNA Probes; D004268:DNA-Binding Proteins; D019309:Epstein-Barr Virus Nuclear Antigens; D016328:NF-kappa B; D009281:Naphthalenes; D011518:Proto-Oncogene Proteins; C497593:RELB protein, human; D012333:RNA, Messenger; D017464:Receptors, Complement 3d; D011991:Receptors, Virus; D014157:Transcription Factors; D051841:Transcription Factor RelB; C058819:calphostin C; D001241:Aspirin