[Predictive factors of non-compliance with anti-tuberculosis treatment in patients infected with the human immunodeficiency virus].
A study was conducted to know the rate of non-compliance of antituberculosis therapy among HIV-infected patients, the factors associated with non-compliance and the evolution of these patients. The therapy compliance in 276 tuberculous HIV infected patients diagnosed in two Madrid hospitals was analyzed. Fifty-one patients (18%) were not included in the analysis (6 died without therapy, 6 were lost and 39 died during therapy). Out of the 225 evaluable patients, 36 (16%, 95% CI, 11.6-21.6) did not comply with therapy. The only factor associated with a higher therapy non-compliance was the antecedent of drug use (20% of non-compliance; relative risk: 10, 95% CI, 1.4-71). Patients using drugs at tuberculosis diagnosis had higher risk for non-compliance (31%; RR, 3.1; 95% CI, 1.6-6.3). The incidence of tuberculosis reactivation after leaving therapy was 78.8/100 patient-years. Therapy non-compliance increased death risk associated with tuberculosis (RR, 9.8; 95% CI, 4.6-21). Programs for controlling antituberculous therapy should give priority to active drug users, as this is the group with the highest risk for non-compliance.
Pulido Ortega
F
F
Unidad VIH, Hospital 12 de Octubre, Madrid.
Sánchez de Rivera
J M
JM
Rubio García
R
R
González García
J
J
Costa Pérez-Herrero
J R
JR
Vázquez Rodríguez
J J
JJ
del Palacio Pérez-Medel
A
A
D000328:Adult; D005260:Female; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D008297:Male; D012306:Risk; D016312:Treatment Refusal / Q000706:statistics & numerical data*; D014376:Tuberculosis / Q000150:complications / Q000188:drug therapy*