title: Distinct and specific functions of cGMP-dependent protein kinases.
abstract: cGMP-dependent protein kinases I and II conduct signals from widespread signaling systems. Whereas the type I kinase mediates numerous effects of natriuretic peptides and nitric oxide in cardiovascular cells, the type II kinase transduces signals from the Escherichia coli heat-stable enterotoxin, STa, and from the endogenous intestinal peptide, guanylin, stimulating Cl- conductance of the cystic fibrosis transmembrane conductance regulator (CFTR). Although the two kinases may be interchangeable for several functions, CFTR regulation specifically requires the type II kinase.
authors.affiliation: University of Würzburg, Germany. slohmann@klin-biochem
authors.forename: S M
authors.initials: SM
authors.lastname: Lohmann
authors.forename: A B
authors.initials: AB
authors.lastname: Vaandrager
authors.forename: A
authors.initials: A
authors.lastname: Smolenski
authors.forename: U
authors.initials: U
authors.lastname: Walter
authors.forename: H R
authors.initials: HR
authors.lastname: De Jonge
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D006152:Cyclic GMP / Q000378:metabolism; D017869:Cyclic GMP-Dependent Protein Kinases / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D015971:Gene Expression Regulation, Enzymologic; D006801:Humans; D015398:Signal Transduction; D013045:Species Specificity
chemical_list: D017869:Cyclic GMP-Dependent Protein Kinases; D006152:Cyclic GMP