title: Gallstone dissolution with oral bile acid therapy. Importance of pretreatment CT scanning and reasons for nonresponse.
abstract: In patients with cholesterol-rich gallbladder stones and a patent cystic duct, complete stone clearance rates of 65-90% have been reported with oral bile acids (OBAs) alone or with adjuvant lithotripsy (extracorporeal shock-wave lithotripsy; ESWL). The aims of the present study were to analyze pretreatment gallstone characteristics that predict the speed and completeness of dissolution with OBAs +/- ESWL, and to assess, in patients with incomplete dissolution, the reasons for the poor response. We compared pretreatment gallstone characteristics in 43 patients who became stone-free after a median of 9 months OBAs +/- ESWL with those in 43 age- and sex-matched patients whose stones failed to dissolve after two years of treatment. In those with incomplete gallstone dissolution, we repeated the oral cholecystogram and computed tomogram (CT) and, in selected patients, obtained gallbladder bile by percutaneous fine-needle puncture. In patients who became stone-free, those with stones that were isodense with bile and/or had CT scores of < 75 Hounsfield units had the fastest dissolution rates. In the 43 nonresponders, the main causes for treatment failure were impaired gallbladder contractility and acquired stone calcification. CT-lucent, noncholesterol stones, or failure of desaturation of bile with the prescribed bile acids, occurred in a minority. We conclude that the pretreatment CT attenuation score predicts both the speed and completeness of gallstone dissolution. In patients with incomplete stone dissolution, the combination of oral cholecystography, CT, and analysis of gallbladder bile will determine the underlying reasons for treatment failure in most, but not all, cases.
authors.affiliation: Gastroenterology Unit, Guy's Hospital, London, UK.
authors.forename: S P
authors.initials: SP
authors.lastname: Pereira
authors.forename: M J
authors.initials: MJ
authors.lastname: Veysey
authors.forename: C
authors.initials: C
authors.lastname: Kennedy
authors.forename: S H
authors.initials: SH
authors.lastname: Hussaini
authors.forename: G M
authors.initials: GM
authors.lastname: Murphy
authors.forename: R H
authors.initials: RH
authors.lastname: Dowling
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D002635:Chenodeoxycholic Acid / Q000008:administration & dosage*; D002769:Cholelithiasis / Q000000981:diagnostic imaging / Q000188:drug therapy*; D003131:Combined Modality Therapy; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008096:Lithotripsy; D008297:Male; D008875:Middle Aged; D014057:Tomography, X-Ray Computed; D017211:Treatment Failure; D014580:Ursodeoxycholic Acid / Q000008:administration & dosage*
chemical_list: D002635:Chenodeoxycholic Acid; D014580:Ursodeoxycholic Acid