title: MR differentiation of phaeochromocytoma from other adrenal lesions based on qualitative analysis of T2 relaxation times.
abstract: OBJECTIVE
  To determine the diagnostic accuracy of MR imaging in differentiating phaeochromocytoma from other adrenal lesions.
  
  
  METHODS
  Sixty-seven adrenal masses (65 patients) including 17 phaeochromocytomas were imaged using T2-weighted pulse sequences on 0.6 T and 1.5 T GE MR units. The adrenal lesions were qualitatively assessed by three observers and divided into three categories (benign adenomas, malignant lesions and phaeochromocytomas) based on lesion signal intensity relative to liver and cerebrospinal fluid.
  
  
  RESULTS
  Eleven phaeochromocytomas (65%) were correctly identified while the remaining six (35%) were misclassified, five as malignant lesions and one as a benign adenoma, because of atypical low signal intensity on T2-weighted MR images. Conversely, six non-phaeochromocytomas (three benign adenomas, two adrenal carcinomas and one metastasis) were wrongly classified as phaeochromocytomas because of very high lesion signal intensity. The sensitivity of MR imaging for diagnosing phaeochromocytoma was 64.7%, specificity 88.0%, positive predictive value 64.7% and negative predictive value 88.0%.
  
  
  CONCLUSIONS
  There is considerable overlap between the MR appearance of phaeochromocytoma and other adrenal lesions. A phaeochromocytoma cannot be excluded on the basis of a lack of high signal intensity on T2-weighted MR imaging.
authors.affiliation: Department of Radiology, Massachusetts General Hospital and Harvard Medical School, USA.
authors.forename: J C
authors.initials: JC
authors.lastname: Varghese
authors.forename: P F
authors.initials: PF
authors.lastname: Hahn
authors.forename: N
authors.initials: N
authors.lastname: Papanicolaou
authors.forename: W W
authors.initials: WW
authors.lastname: Mayo-Smith
authors.forename: J A
authors.initials: JA
authors.lastname: Gaa
authors.forename: M J
authors.initials: MJ
authors.lastname: Lee
mesh_terms: D000236:Adenoma / Q000175:diagnosis; D000310:Adrenal Gland Neoplasms / Q000175:diagnosis* / Q000556:secondary; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010673:Pheochromocytoma / Q000175:diagnosis*; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D012680:Sensitivity and Specificity