title: The predictive value of stress shielding for quantification of adaptive bone resorption around hip replacements.
abstract: The presence of a femoral hip stem changes local mechanical signals inside the surrounding bone. In this study we examined the hypothesis that the eventual loss of bone can be estimated from the initial patterns of elastic energy deviation, as determined in FE models of the intact bone and the operated femur. For that purpose two hypothetical relations between elastic energy reduction and resorption were investigated. Their estimates of bone loss were compared to the results of iterative computer simulations. Two kinds of FE model were used, and in each stem stiffness and remodeling threshold (a measure of "biological reactivity") were varied. Provided that reasonable values of the remodeling threshold are assumed and that the stem is firmly bonded to the bone, we found that the difference between direct estimates and simulation models was 4 percent of bone loss. It is therefore concluded that initial patterns of elastic energy deviation give a reasonable indication of expected bone loss.
authors.affiliation: Biomechanics Section, University of Nijmegen, The Netherlands.
authors.forename: J H
authors.initials: JH
authors.lastname: Kuiper
authors.forename: R
authors.initials: R
authors.lastname: Huiskes
mesh_terms: D000222:Adaptation, Physiological; D001672:Biocompatible Materials; D015519:Bone Density / Q000502:physiology; D001862:Bone Resorption / Q000503:physiopathology*; D004548:Elasticity; D006622:Hip Prosthesis; D006801:Humans; D008954:Models, Biological; D011237:Predictive Value of Tests; D011474:Prosthesis Design; D013314:Stress, Mechanical; D014025:Titanium
chemical_list: D001672:Biocompatible Materials; D014025:Titanium