title: Oculomotor pathology in Menière's disease.
abstract: In this study data of voluntary eye movements 62 patients (mean age was 49.6 years) with Meniere's disease and 38 healthy control subjects were examined. Pseudo-random smooth pursuit (PRPEM) tests were conducted with frequency combination of 0.25 and 0.425 Hz. Saccades at constant targets and pseudo-randomly shifting targets were evaluated. In logistic regression analysis constant saccades correctly classified the cases in 57% as saccadic latency discriminating the groups best, latency being longer in Meniere group. In pseudo-random saccades, correct classification was achieved in 75.4% of all cases as latency discriminating the groups best, and latency was longer in Meniere group. In PRPEM, correct classification was achieved in 65.3% of all cases as gain by amplitude (GA), discriminating the groups best, and GA was smaller in Meniere group. Pseudo-random saccade test is a demanding task and that may explain why a peripheral vestibular lesion may interfere visual tracking and scanning performance. Latency is the most vulnerable of parameters to be lesioned. Results indicate that a peripheral vestibular lesion influences the control of voluntary eye movements and may explain the complaints of visual targeting on objects that patients with Meniere's disease have.
authors.affiliation: Department of Otorhinolaryngology, University Hospital of Helsinki, Finland.
authors.forename: E
authors.initials: E
authors.lastname: Isotalo
authors.forename: I
authors.initials: I
authors.lastname: Pyykkö
mesh_terms: D016022:Case-Control Studies; D005133:Eye Movements / Q000502:physiology*; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008575:Meniere Disease / Q000175:diagnosis / Q000503:physiopathology*; D008875:Middle Aged; D009801:Oculomotor Muscles / Q000503:physiopathology*; D011698:Pursuit, Smooth / Q000502:physiology; D011930:Reaction Time; D012438:Saccades / Q000502:physiology