The CD40-CD154 system in anti-infective host defense.
Research in the past few years has documented significant advances in our understanding of the CD40-CD40 ligand (CD154) system in diverse immune functions. This system influences many T cell mediated inflammatory immune responses and effector functions, unmasking a previously unexpected role for CD40-CD154 in cell mediated immunity. Manipulation of CD154 in animal models of infection by the use of CD154-deficient mice or anti-CD154 antibodies has shown the importance of this system in the initiation of the inflammatory response, in the activation of antigen-presenting cells and in resistance to infections.
Grewal
I S
IS
Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.
Borrow
P
P
Pamer
E G
EG
Oldstone
M B
MB
Flavell
R A
RA
D000818:Animals; D017951:Antigen Presentation; D001899:Borrelia Infections / Q000276:immunology; D019013:CD40 Antigens / Q000276:immunology*; D023201:CD40 Ligand; D006801:Humans; D007239:Infections / Q000276:immunology*; D007896:Leishmaniasis / Q000276:immunology; D008088:Listeriosis / Q000276:immunology; D008262:Macrophage Activation; D008562:Membrane Glycoproteins / Q000276:immunology*; D051379:Mice; D009349:Nematode Infections / Q000276:immunology; D016720:Pneumocystis Infections / Q000276:immunology; D016176:T-Lymphocyte Subsets / Q000276:immunology*
D019013:CD40 Antigens; D008562:Membrane Glycoproteins; D023201:CD40 Ligand