title: Advances and perspectives in acne therapy.
abstract: Acne is one of the most common diseases in dermatology. It is of considerable esthetic significance, which explains the mental stress in affected patients. Although acne almost always heals spontaneously in early adulthood, treatment measures can shorten the course, reduce the severity of the disease, and avoid complications such as scarring. Treatment has changed substantially in recent years. In accordance with pathogenic principles, effective treatment is possible. In most patients, a combination of drugs aimed at correcting abnormal keratinization and reducing the proliferation of Propionibacterium acnes is sufficient to control the disease. For more severely affected patients with no response to this approach, therapy to suppress sebum production is indicated. Of all therapeutic modalities available, only oral isotretinoin alters the natural course of the disease. In acne inversa, surgical management should be undertaken as early as possible.
authors.affiliation: Department of Dermatology, Ludwig-Maximilians-University, Frauenlobstr. 9-11, Munich, D-80337, Germany.
authors.forename: T
authors.initials: T
authors.lastname: Jansen
authors.forename: G
authors.initials: G
authors.lastname: Plewig
mesh_terms: D000152:Acne Vulgaris / Q000601:surgery / Q000628:therapy*; D000287:Administration, Topical; D000726:Androgen Antagonists / Q000008:administration & dosage / Q000627:therapeutic use; D000891:Anti-Infective Agents, Local / Q000627:therapeutic use; D001585:Benzoyl Peroxide / Q000627:therapeutic use; D003879:Dermatologic Agents / Q000627:therapeutic use; D003998:Dicarboxylic Acids / Q000627:therapeutic use; D004232:Diuretics / Q000627:therapeutic use; D006801:Humans; D007641:Keratolytic Agents / Q000627:therapeutic use; D010789:Phototherapy; D014212:Tretinoin / Q000627:therapeutic use; D015032:Zinc / Q000627:therapeutic use
chemical_list: D000726:Androgen Antagonists; D000891:Anti-Infective Agents, Local; D003879:Dermatologic Agents; D003998:Dicarboxylic Acids; D004232:Diuretics; D007641:Keratolytic Agents; D014212:Tretinoin; C010038:azelaic acid; D015032:Zinc; D001585:Benzoyl Peroxide