[Insulin resistance and hyperlipidemia in the elderly].
To elucidate the relationship between hyperlipidemias and insulin resistance in the elderly, we conducted three studies: 1) determination of the prevalence of hyperlipidemias in elderly subjects with impaired glucose tolerance or non-insulin dependent diabetes mellitus, 2) measurement of plasma glucose and insulin levels in patients with phyerlipidemias and atherosclerotic vascular disease, and 3) computation of correlation between levels of substances involved in coagulation and fibrinolysis (F-VII, F-X, and PAI-1) and levels of triglycerides and insulin in serum in hyperlipidemic patients with atherosclerotic vascular disease. The prevalence of hypertriglyceridemia was 4% in non-diabetic control subjects, 38% in subjects with impaired glucose tolerance, 22% in those with diabetes, and 29% in those with both conditions. Levels of glucose and insulin in plasma were measured after oral intake of 75 g of glucose. The insulin response was greater in the group with hypertriglyceridemia than in the group with normal triglyceride levels, although the glucose responses did not differ between the groups. The activities and levels of F-VII, F-X, and PAI-1 correlated with triglycerides in serum and also with fasting insulin levels in hyperlipidemic patients with atherosclerotic vascular disease. We conclude that hypertriglyceridemia plays an important role in the development of atherothrombotic vascular disease; it accompanies elevation of coagulation and antifibrinolytic activities in elderly patients with insulin resistance.
Ohni
M
M
Department of Medicine and Gerontology, Kyorin University School of Medicine.
Mizukawa
S
S
Nakajima
K
K
Yamamoto
M
M
Hata
Y
Y
D000328:Adult; D000368:Aged; D000375:Aging / Q000502:physiology*; D001777:Blood Coagulation; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D005260:Female; D018149:Glucose Intolerance / Q000150:complications; D006801:Humans; D006949:Hyperlipidemias / Q000503:physiopathology*; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D014280:Triglycerides / Q000097:blood
D008076:Cholesterol, HDL; D014280:Triglycerides; D002784:Cholesterol