title: Efficacy of enalapril after ineffective theophylline treatment on erythrocytosis after renal transplantation.
abstract: Erythrocytosis represents a common complication in renal allograft recipients. Traditional therapies including phlebotomy and bilateral native nephrectomies are cumbersome for both the clinical personnel and the patient. Recently, pharmacological agents such as angiotensin converting enzyme inhibitor and theophylline have been proposed as effective therapies for post-transplant erythrocytosis (PTE). We have treated a PTE patient successfully with enalapril without any side effects and renal dysfunction after theophylline treatment showed no improvement in PTE. A decline in Ht levels was independent of the changes in Epo levels during enalapril treatment. Although the mechanism underlying the beneficial effect of enalapril remains undetermined, enalapril is recommended for the initial treatment of PTE.
authors.affiliation: Department of Urology, Yamagata University School of Medicine, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Yagisawa
authors.forename: H
authors.initials: H
authors.lastname: Toma
authors.forename: H
authors.initials: H
authors.lastname: Yaguchi
authors.forename: M
authors.initials: M
authors.lastname: Tomaru
authors.forename: Y
authors.initials: Y
authors.lastname: Iijima
authors.forename: H
authors.initials: H
authors.lastname: Suzuki
authors.forename: T
authors.initials: T
authors.lastname: Nakada
mesh_terms: D000241:Adenosine / Q000037:antagonists & inhibitors; D000328:Adult; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use*; D004656:Enalapril / Q000627:therapeutic use*; D004921:Erythropoietin / Q000097:blood; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D011086:Polycythemia / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D011183:Postoperative Complications / Q000188:drug therapy*; D013806:Theophylline / Q000627:therapeutic use
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D004921:Erythropoietin; D004656:Enalapril; D013806:Theophylline; D000241:Adenosine