title: The National Institute on Drug Abuse Collaborative Cocaine Treatment Study. Rationale and methods.
abstract: The National Institute on Drug Abuse Collaborative Cocaine Treatment Study is a large, multisite psychotherapy clinical trial for outpatients who meet the DSM-IV criteria for cocaine dependence. For 480 randomized patients, the outcomes of 4 treatments are compared for an 18-month period. All treatments include group drug counseling. One treatment also adds cognitive therapy, one adds supportive-expressive psychodynamic therapy, and one adds individual drug counseling; one consists of group drug counseling alone. In addition, 2 specific interaction hypotheses, one involving psychiatric severity and the other involving degree of antisocial personality characteristics, are being tested. This article describes the main aims of the project, the background and rationale for the study design, the rationale for the choice of treatments and patient population, and a brief description of the research plan.
authors.affiliation: Department of Psychiatry, University of Pennsylvania, Philadelphia, USA.
authors.forename: P
authors.initials: P
authors.lastname: Crits-Christoph
authors.forename: L
authors.initials: L
authors.lastname: Siqueland
authors.forename: J
authors.initials: J
authors.lastname: Blaine
authors.forename: A
authors.initials: A
authors.lastname: Frank
authors.forename: L
authors.initials: L
authors.lastname: Luborsky
authors.forename: L S
authors.initials: LS
authors.lastname: Onken
authors.forename: L
authors.initials: L
authors.lastname: Muenz
authors.forename: M E
authors.initials: ME
authors.lastname: Thase
authors.forename: R D
authors.initials: RD
authors.lastname: Weiss
authors.forename: D R
authors.initials: DR
authors.lastname: Gastfriend
authors.forename: G
authors.initials: G
authors.lastname: Woody
authors.forename: J P
authors.initials: JP
authors.lastname: Barber
authors.forename: S F
authors.initials: SF
authors.lastname: Butler
authors.forename: D
authors.initials: D
authors.lastname: Daley
authors.forename: S
authors.initials: S
authors.lastname: Bishop
authors.forename: L M
authors.initials: LM
authors.lastname: Najavits
authors.forename: J
authors.initials: J
authors.lastname: Lis
authors.forename: D
authors.initials: D
authors.lastname: Mercer
authors.forename: M L
authors.initials: ML
authors.lastname: Griffin
authors.forename: K
authors.initials: K
authors.lastname: Moras
authors.forename: A T
authors.initials: AT
authors.lastname: Beck
mesh_terms: D000553:Ambulatory Care; D000987:Antisocial Personality Disorder / Q000453:epidemiology / Q000628:therapy; D002985:Clinical Protocols; D003042:Cocaine; D015897:Comorbidity; D003376:Counseling; D017831:Diagnosis, Dual (Psychiatry); D006801:Humans; D009316:National Institutes of Health (U.S.); D009293:Opioid-Related Disorders / Q000453:epidemiology / Q000628:therapy*; D018579:Patient Selection; D011613:Psychotherapy; D012107:Research Design; D012720:Severity of Illness Index; D014481:United States
chemical_list: D003042:Cocaine