[Effect of tea extracts, catechin and caffeine against type-I allergic reaction].
The antiallergic effects of green tea, oolong tea, and black tea extracts by hot water were examined. These extracts inhibited the passive cutaneous anaphylaxis (PCA) reaction of rat after oral administration. Three tea catechins, (--)-epigallocatechin (EGC), (--)-epicatechin gallate (ECg), and (--)-epigallocatechin gallate (EGCg) isolated from green tea showed stronger inhibitory effects than that of a green tea extract on the PCA reaction. The inhibitory effects of EGC and EGCg on the PCA reaction were greater than that of ECg. Caffeine also showed a inhibitory effect on the PCA reaction. These results indicate that tea could provide a significant protection against the type-I allergic reaction. These findings also suggest that tea catechins and caffeine play an important role in having an inhibitory effect on the type-I allergic reaction.
Shiozaki
T
T
Institute of Traditional Chinese Medicines, School of Pharmaceutical Sciences, University of Shizuoka, Japan.
Sugiyama
K
K
Nakazato
K
K
Takeo
T
T
D000284:Administration, Oral; D000818:Animals; D002110:Caffeine / Q000302:isolation & purification / Q000494:pharmacology*; D002392:Catechin / Q000031:analogs & derivatives / Q000302:isolation & purification / Q000494:pharmacology*; D003864:Depression, Chemical; D005419:Flavonoids / Q000302:isolation & purification / Q000494:pharmacology; D006969:Hypersensitivity, Immediate / Q000517:prevention & control; D008297:Male; D010323:Passive Cutaneous Anaphylaxis / Q000187:drug effects*; D010936:Plant Extracts / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013662:Tea
D005419:Flavonoids; D010936:Plant Extracts; D013662:Tea; D002110:Caffeine; D002392:Catechin; C062669:epicatechin gallate; C045651:epigallocatechin gallate; C057580:gallocatechol