Transdermal therapy and diagnosis by iontophoresis.
Iontophoresis, the use of an electric current to drive charged molecules across the skin, has the potential to expand the feasible range of drugs for transdermal administration significantly. This method of delivery is being examined carefully with respect to higher-molecular-weight therapeutics (in particular, peptides and small proteins), which cannot be absorbed following oral administration and for which, at this time, an invasive injection remains the only option. In addition, the procedure of so-called 'reverse' iontophoresis would appear to represent a truly noninvasive approach for diagnostic monitoring of blood chemistry.
Merino
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V
Centre Interuniversitaire de Recherche et d'Enseignement, Pharmapeptides, Parc d'Affaires International, Archamps, France.
Kalia
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YN
Guy
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RH
D000279:Administration, Cutaneous; D001709:Biotechnology / Q000639:trends*; D006801:Humans; D007478:Iontophoresis / Q000379:methods*; D010455:Peptides / Q000008:administration & dosage*; D012871:Skin Diseases / Q000175:diagnosis* / Q000628:therapy*
D010455:Peptides