Markers of haemostatic activation before and after blood donation and plasmapheresis.
OBJECTIVE
Previous studies have reported signs of haemostatic activation after haemorrhage. The aim of this study was to measure sensitive markers for haemostatic activation after blood donation or plasmapheresis in healthy donors.


METHODS
Blood samples were drawn before as well as 5 min and 1 h after donation in 40 male donors, of whom 29 gave 1 unit of blood and 11 underwent plasmapheresis. Standard assays were used.


RESULTS
Plasma concentrations of the activation markers prothrombin fragment 1 + 2, thrombin-antithrombin complexes, and von Willebrand factor did not increase after blood or plasma donation.


CONCLUSIONS
In our opinion, these procedures are safe.
Rahr
H B
HB
Centre for Haemophilia & Thrombosis, Aarhus University Hospital, Denmark. hansrahr@postl.tele.dk
Roman
C
C
Ingerslev
J
J
Jørgensen
J
J
D000328:Adult; D015415:Biomarkers / Q000737:chemistry; D001782:Blood Donors; D006487:Hemostasis / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010956:Plasmapheresis; D013997:Time Factors
D015415:Biomarkers