[Obesity may have more pronounced effect on the occurrence of insulin resistance than hypertension].
OBJECTIVE
To compare the extent of insulin resistance in hypertensive and in obesity patients and verify their role on the occurrence of insulin resistance.


METHODS
Insulin sensitivity was assessed by using euglycemic insulin clamp technique (EICT) in normal subjects (NS, n = 36), obesity (n = 23), hypertensive non-obesity patients (HT+nonobesity, n = 51) and hypertensive and obesity patients (HT+obesity, n = 54) Glucose metabolism ratio (M) served as an index of insulin sensitivity.


RESULTS
The height sequence of M value was: NS > HT+nonobesity > obesity > HT+obesity (ie, 9.2 +/- 1.0 > 7.6 +/- 2.0 > 6.7 +/- 1.5 > 5.2 +/- 1.8 mg.kg-1.min-1, P < 0.05). The incidence rate of decreased insulin sensitivity among the four groups was: HT+obesity > obesity > HT+nonobesity > NS (87.0%, 69.6%, 41.1% and 2.8%, P < 0.05). After adjusting for age, sex and BMI, M value was greater in normotensives (n = 59) than in hypertension patients (n = 105) (8.0 versus 6.6 mg.kg-1min-1, P < 0.01). Multivariates analysis showed that BMI and SBP are the two most important determinants for M value, but the effect of 1 kg/m2 BMI is equivalent to that of 20 mmHg SBP.


CONCLUSIONS
Decreased insulin sensitivity may be the common linkage between obesity and hypertension. Obesity may have more pronounced effect on insulin sensitivity than hypertension.
Chen
D
D
Department of Cardiology, First Affiliated Hospital, Fujian Medical College, Fuzhou.
Lin
J
J
Zeng
K
K
D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D005260:Female; D015309:Glucose Clamp Technique; D006801:Humans; D006973:Hypertension / Q000378:metabolism*; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000378:metabolism*; D012044:Regression Analysis
D001786:Blood Glucose