Epstein-Barr virus associated B-cell lymphoma after autologous bone marrow transplantation for T-cell acute lymphoblastic leukaemia.
Epstein-Barr virus associated lymphoproliferative disease after autologous bone marrow transplantation (ABMT) has rarely been reported. We report a case of B-cell lymphoma following ABMT for T-acute lymphoblastic leukaemia; bone marrow was purged in vitro with monoclonal antibodies to remove T cells. Immunoglobulin and T-cell receptor gene rearrangement studies were used to demonstrate clonality and to show that this patient developed a second neoplasm after ABMT. EBV proteins and genome (type A) were present in post-transplantation lymphoma, suggesting a causative role in its development.
Briz
M
M
Department of Haematology, Hospital Puerta de Hierro, Universidad Autónoma de Madrid, Spain.
Forés
R
R
Regidor
C
C
Busto
M J
MJ
Ramon y Cajal
S
S
Cabrera
R
R
Díez
J L
JL
Sanjuán
I
I
Fernández
M N
MN
D000368:Aged; D015139:Blotting, Southern; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D002051:Burkitt Lymphoma / Q000628:therapy*; D015326:Gene Rearrangement, B-Lymphocyte, Heavy Chain; D015329:Gene Rearrangement, T-Lymphocyte; D006566:Herpesviridae Infections / Q000150:complications*; D004854:Herpesvirus 4, Human / Q000302:isolation & purification; D006801:Humans; D016393:Lymphoma, B-Cell / Q000821:virology*; D008297:Male; D014412:Tumor Virus Infections / Q000150:complications*