title: Clinicopathologic analysis of amphiregulin and heregulin immunostaining in breast neoplasia.
abstract: We observed no association between neoplastic epithelial immunostaining for either amphiregulin (AR) or heregulin (HRG) and presence of ER, EGFR/ERBB-2 overexpression, nodal status, or disease recurrence in 34 breast carcinomas. However, stromal cell staining for both correlated with outcome; 29% of stromal cell AR - cases recurred vs. 85% for AR + cases (p = 0.001), and 41% of stromal cell HRG - cases recurred vs. 82% of HRG + cases (p = 0.01). We conclude that both HRG and AR have significant biologic roles in breast carcinoma growth or progression via mediation of host-tumor interactions which favor aggressive tumor behavior.
authors.affiliation: Department of Pathology, Harper Hospital, Detroit, MI 48201, USA.
authors.forename: D W
authors.initials: DW
authors.lastname: Visscher
authors.forename: F H
authors.initials: FH
authors.lastname: Sarkar
authors.forename: T C
authors.initials: TC
authors.lastname: Kasunic
authors.forename: K B
authors.initials: KB
authors.lastname: Reddy
mesh_terms: D066258:Amphiregulin; D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology; D002277:Carcinoma / Q000378:metabolism* / Q000473:pathology; D066255:EGF Family of Proteins; D005260:Female; D006023:Glycoproteins / Q000032:analysis*; D006133:Growth Substances / Q000032:analysis*; D006801:Humans; D007150:Immunohistochemistry; D036341:Intercellular Signaling Peptides and Proteins; D020880:Neuregulins
chemical_list: C587848:AREG protein, human; D066258:Amphiregulin; D066255:EGF Family of Proteins; D006023:Glycoproteins; D006133:Growth Substances; D036341:Intercellular Signaling Peptides and Proteins; D020880:Neuregulins