title: Effect of gentamycin on the melanosomes in the stria vascularis of the pigmented guinea pig: an ultrastructural study.
abstract: Melanosomes of the stria vascularis in gentamycin (GM)-intoxicated guinea pigs were examined ultrastructurally. Experimental animals were given GM sulfate intramuscularly in a daily adjusted dose of 100 mg/kg for 15 consecutive days (group A), and 150 mg/kg for 5 consecutive days (group B). Melanosomes of the intermediate cells in group B significantly increased in number in comparison with those in group A and the control group. Melanosomes in the apical turn outnumbered those in the basal turn in all three groups. Cytochemically, Na+, K(+)-ATPase activity was also demonstrated in the marginal cells. There was little difference in the degree of enzyme activity between groups A, B and the control group. The role and significance of melanosomes of the stria vascularis are discussed.
authors.affiliation: Department of Otolaryngology, Tokyo Women's Medical College, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Yoshihara
authors.forename: N
authors.initials: N
authors.lastname: Mita
authors.forename: M
authors.initials: M
authors.lastname: Satoh
authors.forename: H
authors.initials: H
authors.lastname: Kaname
authors.forename: M
authors.initials: M
authors.lastname: Morita
authors.forename: T
authors.initials: T
authors.lastname: Ishii
authors.forename: M
authors.initials: M
authors.lastname: Igarashi
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects*; D002196:Capillaries / Q000187:drug effects / Q000201:enzymology / Q000648:ultrastructure; D002452:Cell Count / Q000187:drug effects; D003593:Cytoplasm / Q000187:drug effects / Q000201:enzymology / Q000648:ultrastructure; D004334:Drug Administration Schedule; D005839:Gentamicins / Q000008:administration & dosage / Q000009:adverse effects*; D006168:Guinea Pigs; D006651:Histocytochemistry; D007273:Injections, Intramuscular; D008544:Melanocytes / Q000187:drug effects* / Q000201:enzymology / Q000648:ultrastructure; D000254:Sodium-Potassium-Exchanging ATPase / Q000187:drug effects / Q000378:metabolism; D013316:Stria Vascularis / Q000187:drug effects* / Q000201:enzymology / Q000648:ultrastructure; D014617:Vacuoles / Q000187:drug effects / Q000201:enzymology / Q000648:ultrastructure
chemical_list: D000900:Anti-Bacterial Agents; D005839:Gentamicins; D000254:Sodium-Potassium-Exchanging ATPase