[Human mucoepidermoid carcinoma MEC-1 cells induced differentiation by HMBA].
Mucoepidermoid carcinoma is the most common malignant tumor of salivary glands. In this report, we used hexamethylene bisacetamide (HMBA) as a inducer to induce human mucoepidermoid carcinoma cell line MEC-1 cells to differentiate. The growth kinetics, morphological changes and DNA contents of the cells were investigated. The results showed that HMBA-treated MEC-1 cells tend to become mature cells, implying that HMBA can induce differentiation of MEC-1 cells in vitro.
Chen
Y
Y
Molecular Biology Department of Naval General Hospital, Beijing.
SiTu
Z
Z
Wu
J
J
D000081:Acetamides / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000494:pharmacology*; D018277:Carcinoma, Mucoepidermoid / Q000378:metabolism / Q000473:pathology*; D002471:Cell Transformation, Neoplastic / Q000187:drug effects*; D004273:DNA, Neoplasm / Q000378:metabolism; D006801:Humans; D012468:Salivary Gland Neoplasms / Q000378:metabolism / Q000473:pathology*; D014407:Tumor Cells, Cultured
D000081:Acetamides; D000970:Antineoplastic Agents; D004273:DNA, Neoplasm; C014026:hexamethylene bisacetamide