Unsuccessful CTL transfusion in a case of post-BMT Epstein-Barr virus-associated lymphoproliferative disorder (EBV-LPD).
A patient with AML (FAB M4Eo) developed EBV-LPD 1.5 months after allogeneic BMT from his one locus-mismatched mother, the diagnosis being confirmed on day +82. Attempts to eradicate the monoclonally proliferating LPD using chemotherapy (VP16/dexamethasone) followed by two doses of EBV-specific CTL and one dose of unstimulated donor leukocytes were not successful. We assume delay of infusions (day +100, +107) and insufficient CTL cell doses (total 9.2 x 10(6)) may have been responsible for the poor outcome in this case.
Imashuku
S
S
Division of Pediatrics, Children's Research Hospital, Kyoto, Japan.
Goto
T
T
Matsumura
T
T
Naya
M
M
Yamori
M
M
Hojo
M
M
Hibi
S
S
Todo
S
S
D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D002648:Child; D006566:Herpesviridae Infections / Q000209:etiology / Q000628:therapy*; D004854:Herpesvirus 4, Human; D006801:Humans; D008232:Lymphoproliferative Disorders / Q000209:etiology / Q000628:therapy*; D008297:Male; D013602:T-Lymphocytes, Cytotoxic / Q000637:transplantation*; D014184:Transplantation, Homologous; D014412:Tumor Virus Infections / Q000209:etiology / Q000628:therapy*