title: Unsuccessful CTL transfusion in a case of post-BMT Epstein-Barr virus-associated lymphoproliferative disorder (EBV-LPD).
abstract: A patient with AML (FAB M4Eo) developed EBV-LPD 1.5 months after allogeneic BMT from his one locus-mismatched mother, the diagnosis being confirmed on day +82. Attempts to eradicate the monoclonally proliferating LPD using chemotherapy (VP16/dexamethasone) followed by two doses of EBV-specific CTL and one dose of unstimulated donor leukocytes were not successful. We assume delay of infusions (day +100, +107) and insufficient CTL cell doses (total 9.2 x 10(6)) may have been responsible for the poor outcome in this case.
authors.affiliation: Division of Pediatrics, Children's Research Hospital, Kyoto, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Imashuku
authors.forename: T
authors.initials: T
authors.lastname: Goto
authors.forename: T
authors.initials: T
authors.lastname: Matsumura
authors.forename: M
authors.initials: M
authors.lastname: Naya
authors.forename: M
authors.initials: M
authors.lastname: Yamori
authors.forename: M
authors.initials: M
authors.lastname: Hojo
authors.forename: S
authors.initials: S
authors.lastname: Hibi
authors.forename: S
authors.initials: S
authors.lastname: Todo
mesh_terms: D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D002648:Child; D006566:Herpesviridae Infections / Q000209:etiology / Q000628:therapy*; D004854:Herpesvirus 4, Human; D006801:Humans; D008232:Lymphoproliferative Disorders / Q000209:etiology / Q000628:therapy*; D008297:Male; D013602:T-Lymphocytes, Cytotoxic / Q000637:transplantation*; D014184:Transplantation, Homologous; D014412:Tumor Virus Infections / Q000209:etiology / Q000628:therapy*