Econazole, miconazole and SK & F 96365 inhibit depolarization-induced and receptor-operated contraction of guinea-pig isolated trachea in vitro.
Econazole, miconazole, SK & F 96365 and nifedipine inhibited Ca2+- and depolarization-induced and receptor-operated contraction of guinea-pig isolated trachea. Econazole, miconazole and SK & F 96365 inhibited histamine- and methacholine-induced tracheal contraction more than nifedipine. Nifedipine was more potent in inhibiting KCl-induced contraction. Nifedipine, salbutamol and theophylline, but not econazole, miconazole or SK & F 96365, relaxed KCl, histamine-, and methacholine-precontracted trachea. It appears that in the guinea-pig tracheal smooth muscle, econazole, miconazole and SK & F 96365 behave differently from nifedipine, theophylline and salbutamol. Econazole, miconazole and SK & F 96365 are thus introduced as novel antagonists of receptor-operated airway smooth muscle contraction.
Li
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Institute of Biomedicine, Department of Pharmacology and Toxicology, University of Helsinki, Finland.
Kankaanranta
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H
Vaali
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K
Paakkari
I
I
Vapaatalo
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H
D000818:Animals; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D004464:Econazole / Q000494:pharmacology*; D004533:Egtazic Acid / Q000494:pharmacology; D005260:Female; D006168:Guinea Pigs; D006632:Histamine / Q000494:pharmacology; D007093:Imidazoles / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D008688:Methacholine Compounds / Q000494:pharmacology; D008825:Miconazole / Q000494:pharmacology*; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects*; D009467:Neuromuscular Depolarizing Agents / Q000494:pharmacology*; D011189:Potassium Chloride / Q000494:pharmacology; D014132:Trachea / Q000187:drug effects*
D002121:Calcium Channel Blockers; D007093:Imidazoles; D008688:Methacholine Compounds; D009467:Neuromuscular Depolarizing Agents; D004533:Egtazic Acid; D011189:Potassium Chloride; D004464:Econazole; D008825:Miconazole; D006632:Histamine; C063159:1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole