title: Reduction of the DTH response is related to morphological changes of Langerhans cells in mice exposed to acute immobilization stress.
abstract: There is a large body of evidence indicating that stress influences immune competence. For example, psoriasis and atopic dermatitis may be exacerbated by psychic stress and related to abnormalities in the cellular constituents of the immune system in the skin. However, the underlying mechanisms remain unclear. We therefore investigated the potential of acute immobilization stress to affect the DTH response in BALB/c mice. DTH was significantly reduced in an immobilization time-dependent manner when stress exposure was just before sensitization. Although the number of Langerhans cells (LC) did not change under these conditions, marked alteration of LC morphology was observed with a significant decrease in area. Recovery of LC was observed within 24 h when the DTH response was also restored. Expression of the calcitonin gene-related peptide (CGRP), which inhibits LC antigen presentation, was significantly increased up to 1.6-fold in nerve fibres of immobilized mice. We conclude that stress-induced suppression of DTH could be due to reduction of LC antigen presentation with morphological change in association with CGRP elevation.
authors.affiliation: Research Laboratories, Nippon Menard Cosmetic Co. Ltd, Nagoya, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Kawaguchi
authors.forename: T
authors.initials: T
authors.lastname: Okada
authors.forename: H
authors.initials: H
authors.lastname: Konishi
authors.forename: M
authors.initials: M
authors.lastname: Fujino
authors.forename: J
authors.initials: J
authors.lastname: Asai
authors.forename: M
authors.initials: M
authors.lastname: Ito
mesh_terms: D000208:Acute Disease; D000818:Animals; D015740:Calcitonin Gene-Related Peptide / Q000378:metabolism; D019084:Fluorescent Antibody Technique, Indirect; D000949:Histocompatibility Antigens Class II / Q000276:immunology; D006968:Hypersensitivity, Delayed / Q000276:immunology* / Q000473:pathology; D007103:Immobilization; D007801:Langerhans Cells / Q000276:immunology* / Q000473:pathology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009412:Nerve Fibers / Q000378:metabolism; D012867:Skin / Q000276:immunology / Q000294:innervation / Q000378:metabolism; D013312:Stress, Physiological / Q000276:immunology* / Q000473:pathology; D013997:Time Factors
chemical_list: D000949:Histocompatibility Antigens Class II; D015740:Calcitonin Gene-Related Peptide