title: Shared synteny between human chromosome 10 and chromosome 1 of the marsupial tammar wallaby, Macropus eugenii.
abstract: Marsupial homologs of the human chromosome 10 loci IL2RA, HK1, and PLAU have been cloned and mapped by fluorescence in situ hybridization to chromosome 1q of the tammar wallaby, Macropus eugenii. Relative distance measurements of the hybridization signals on M. eugenii chromosome 1 show that marsupial homologs of human (HSA) 10p IL2RA and 10q HK1/PLAU flank the marsupial homologs of the human 5q gene IL5 and the human 15q imprinted genes SNRPN and ZNF127. The shared synteny, therefore, does not necessarily mean that HSA 10 represents an ancestral grouping; rather, it suggests that HSA 10p and HSA 10q represent two different ancestral mammalian units which fused directly in primates and were incorporated independently into two different regions of the same chromosome in marsupials.
authors.affiliation: School of Genetics and Human Variation, La Trobe University, Bundoora, Melbourne, Australia.
authors.forename: A B
authors.initials: AB
authors.lastname: Spurdle
authors.forename: P
authors.initials: P
authors.lastname: Maccarone
authors.forename: R
authors.initials: R
authors.lastname: Toder
authors.forename: S A
authors.initials: SA
authors.lastname: Wilcox
authors.forename: J A
authors.initials: JA
authors.lastname: Graves
mesh_terms: D000818:Animals; D005075:Biological Evolution; D002874:Chromosome Mapping; D002879:Chromosomes, Human, Pair 10 / Q000235:genetics*; D003001:Cloning, Molecular; D015321:Gene Rearrangement; D016678:Genome; D015894:Genome, Human; D006593:Hexokinase / Q000235:genetics; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007614:Macropodidae / Q000235:genetics*; D008297:Male; D010960:Plasminogen Activators / Q000235:genetics; D015375:Receptors, Interleukin-2 / Q000235:genetics; D013045:Species Specificity
chemical_list: D015375:Receptors, Interleukin-2; D006593:Hexokinase; D010960:Plasminogen Activators