Dendritic cells as immunogens for human CTL responses.
The cellular requirements for generating potent human CD8+ CTLs to influenza A virus in vitro have been defined. Furthermore, we have developed improved methods for generating large numbers of DCs from non-proliferating progenitors. These developments have enabled the design of new strategies to elicit CTLs in vivo. For example, together with IL-12, antigen-pulsed DCs may be a useful approach for boosting CTL responses against infectious agents and malignancies. Our results also reopen the potential use of inactivated virus preparations as immunogens for CTL responses.
Bender
A
A
Rockefeller University, New York 10021, USA.
Sapp
M
M
Feldman
M
M
Reddy
A
A
Seder
R
R
Schuler
G
G
Steinman
R M
RM
Bhardwaj
N
N
D001773:Blood Cells / Q000166:cytology / Q000276:immunology; D002450:Cell Communication; D002454:Cell Differentiation; D003713:Dendritic Cells / Q000166:cytology / Q000276:immunology*; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000276:immunology; D006801:Humans; D066298:In Vitro Techniques; D009980:Influenza A virus / Q000276:immunology; D018664:Interleukin-12 / Q000494:pharmacology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D014611:Vaccination
D018664:Interleukin-12