Clinico-pathological features of colorectal adenomatous polyps with negative results on immunochemical fecal occult blood test.
BACKGROUND
This study was carried out to clarify the clinico-pathological features of colorectal adenomatous polyps showing negative results on an immunochemical fecal occult blood test.


METHODS
Four hundred sixty patients with colorectal adenoma 1.0 cm or larger in diameter served as subjects of this study. They were divided into two groups based on the results of an immunochemical fecal occult blood test with a 3-day method: two hundred twenty four patients with positive results (positive group) and two hundred thirty six patients with negative results (negative group). The above two groups were compared in terms of their individual factors such as lesion site, lesion size, lesion shape, and histological type.


RESULTS
In negative group, the frequencies of rectal adenomatous polyps (p<0.01) and colorectal adenomatous polyps 1.0-1.5 cm in size (p<0.001) were higher, and also pedunculated type (p<0.05) were lower than in positive group, but there was no difference in histological type between the two groups.


CONCLUSIONS
These findings suggest that immunochemical fecal occult blood testing is relatively inferior for the detection of colorectal adenomatous polyps in rectum, smaller size, and non-pedunculated type.
Abdul Fattah
A S
AS
Department of Public Health, Shinshu University School of Medicine Asahi 3-1-1, Matsumoto, 390 Japan. afattah@gipac.shinshu-u.ac.jp
Nakama
H
H
Kamijo
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N
D000236:Adenoma / Q000175:diagnosis / Q000473:pathology; D018256:Adenomatous Polyps / Q000175:diagnosis / Q000473:pathology*; D015179:Colorectal Neoplasms / Q000175:diagnosis / Q000473:pathology*; D004797:Enzyme-Linked Immunosorbent Assay; D005188:False Negative Reactions; D006801:Humans; D009780:Occult Blood; D011933:Reagent Kits, Diagnostic
D011933:Reagent Kits, Diagnostic