[Mild hypercholesterolemia. Diagnosis and prognosis].
The finding of normocholesterolaemia, characterized by plasmatic values of total cholesterol < 2 g/l, which may hide silent lipidic alterations, is not by itself sufficient to rule out the existence of cardiovascular risk. First level screening of patients exposed to atherogenic risk must begin from dosage of three basic lipidic indicators, represented by total cholesterol, triglycerides, and HDL cholesterol. By using the values of the three above-mentioned indicators and by applying Friedewald's formula, it is possible to calculate LDL cholesterol indirectly. Atherogenic risk is present when HDL cholesterol and LDL cholesterol show plasmatic concentration inferior to 0.35 g/l and superior to 1,3 g/l respectively. The European Atherosclerosis Society lists five hyperlipidaemic classes, from A to E, determined on the basis of plasmatic levels of cholesterol and triglycerides. Mild hypercolesterolaemia associated with modest atherogenic risk and which largely occurs in people and is frequently underestimated form a diagnostic point of view, contributes to cardiovascular mortality more considerably than more serious forms of hypercholesterolaemia. On the basis of this observation, there originated the programmatic proposal for the prevention of hyperlipidaemic complications, presented by the Authors.
Raddino
R
R
Cattedra di Cardiologia, Università, Brescia.
Scarabelli
T M
TM
Pelà
G
G
Sarasso
M L
ML
Domenighini
D
D
Fappani
A
A
Visioli
O
O
D001161:Arteriosclerosis / Q000209:etiology / Q000401:mortality; D015992:Body Mass Index; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood / Q000145:classification* / Q000150:complications / Q000175:diagnosis*; D008487:Medical History Taking; D009765:Obesity / Q000097:blood; D010808:Physical Examination; D011379:Prognosis; D012306:Risk; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires
D008076:Cholesterol, HDL; D008078:Cholesterol, LDL