Tolerance to lipopolysaccharide is not related to the ability of the hypothalamus to produce prostaglandin E2.
The effects of repeated administration of Escherichia coli lipopolysaccharide (LPS) on body temperature and hypothalamic prostaglandin E2 (PGE2) production was examined in male Sprague-Dawley rats to elucidate whether the development of endotoxin tolerance is related to the ability of the hypothalamus to produce PGE2. Initial injection of LPS resulted in hyperthermia, preceded by short-termed hypothermia, while no changes in body temperature were observed after the second injection (administered 48 h later). In contrast, LPS induced elevation in hypothalamic PGE2 production after both the first and second injections of the pyrogen. This led us to conclude that endotoxin tolerance is independent of the hypothalamic production of PGE2 in response to repeated administration of LPS.
Chemo
A
A
Department of Clinical Pharmacology, Ben-Gurion University of the Negev, Beer Sheva, Israel.
Fraifeld
V
V
Adramovich
L
L
Sod-Moriah
U A
UA
Kaplanski
J
J
D000818:Animals; D001833:Body Temperature Regulation / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D015232:Dinoprostone / Q000096:biosynthesis*; D004361:Drug Tolerance; D007031:Hypothalamus / Q000187:drug effects* / Q000378:metabolism; D008070:Lipopolysaccharides / Q000494:pharmacology*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
D008070:Lipopolysaccharides; D015232:Dinoprostone