title: Transvaginal interstitial laser treatment of the ovary for the management of chronic hyperandrogenic anovulation: first clinical experience.
abstract: The feasibility of ultrasound-guided transvaginal interstitial laser treatment of the ovary (TILT) and its efficacy for ovulation induction was investigated in 3 hormone-therapy-resistant patients with chronic hyperandrogenic anovulation. TILT was performed at powers of 1-2 W and exposures of 75-600 s. Clear-cut hyperechogenic zones developed during laser irradiation with diameters of up to 13.7 mm. Spontaneous ovulation and/or hormonal changes after TILT did not occur. No adhesion formation was seen during a laparoscopy or laparotomy in 2 patients 6 months after TILT. In conclusion, TILT of the ovaries was simple to perform but so far the clinical results are disappointing. Further studies with a modified technique are necessary to further investigate the efficacy of TILT.
authors.affiliation: Center of Reproductive Medicine, Academic Medical Center, Amsterdam, The Netherlands.
authors.forename: E M
authors.initials: EM
authors.lastname: Kaaijk
authors.forename: F
authors.initials: F
authors.lastname: van der Veen
authors.forename: J F
authors.initials: JF
authors.lastname: Beek
authors.forename: M J
authors.initials: MJ
authors.lastname: van Gemert
authors.forename: F B
authors.initials: FB
authors.lastname: Lammes
mesh_terms: D000328:Adult; D000858:Anovulation / Q000209:etiology / Q000601:surgery*; D005260:Female; D006801:Humans; D017588:Hyperandrogenism / Q000150:complications* / Q000601:surgery; D007247:Infertility, Female / Q000601:surgery*; D053685:Laser Therapy / Q000379:methods*; D010053:Ovary / Q000601:surgery* / Q000648:ultrastructure; D010865:Pilot Projects