title: Improvement of enantioselective syntheses and chiral high resolution gas chromatographic analyses of (+)-2-allyl-2-carboethoxy-cyclopentanol.
abstract: The improvement of the biocatalytic reduction of 2-allyl-carboethoxy-cyclopentanone (2) to the corresponding cyclopentanol derivative (+)-(1R,2R)-(1) was accomplished employing baker's yeast in organic media. This chiral cyclopentanol derivative (1), analyzed by high resolution gas chromatography performed over beta-cyclodextrin stationary phase, was obtained in 38% yield (> 99% e.e.).
authors.affiliation: LASSBio, Faculdade de Farmácia, Universidade Federal do Rio de Janeiro, Brazil.
authors.forename: C A
authors.initials: CA
authors.lastname: Fraga
authors.forename: E J
authors.initials: EJ
authors.lastname: Barreiro
authors.forename: E F
authors.initials: EF
authors.lastname: da Silva
authors.forename: A R
authors.initials: AR
authors.lastname: dos Santos
authors.lastname: KV Ramos MdaC
authors.forename: F R
authors.initials: FR
authors.lastname: de Aquino Neto
mesh_terms: D000498:Allyl Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D002849:Chromatography, Gas; D003517:Cyclopentanes / Q000138:chemical synthesis* / Q000737:chemistry; D010084:Oxidation-Reduction; D012441:Saccharomyces cerevisiae / Q000201:enzymology; D013237:Stereoisomerism
chemical_list: C108404:2-allyl-2-carboethoxycyclopentanol; D000498:Allyl Compounds; D003517:Cyclopentanes