title: Evaluation of confounding effects in ROC studies.
abstract: In many clinical studies, it is clear that external forces can affect the performance of diagnostic tests, as these factors influence the distributions of separator variables. A new estimator for the receiver operating characteristic (ROC) function is proposed; this estimator converges to the ROC function uniformly on the interval [0,1]. Using this new estimator, the author proposes to use Cox's proportional hazards regression model for the evaluation of confounding effects in ROC studies. The method can be used even when concomitant information is only available for the cases, for example, disease severity. A textbook example on prostate cancer is described for illustration.
authors.affiliation: School of Public Health and Cancer Center, University of Minnesota, Minneapolis 55455, USA.
authors.forename: C T
authors.initials: CT
authors.lastname: Le
mesh_terms: D000368:Aged; D001699:Biometry / Q000379:methods; D003933:Diagnosis; D004812:Epidemiologic Methods; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D015233:Models, Statistical; D011237:Predictive Value of Tests; D011379:Prognosis; D016016:Proportional Hazards Models; D011471:Prostatic Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D015203:Reproducibility of Results