[Factor V Leiden and activated protein C resistance].
Factor V Leiden is characterised by a point mutation which prevents the physiologic inhibition of activated factor V by activated protein C (Activated Protein C Resistance). This mutation is now considered as the most frequent inherited thrombophilic disorder. It is found in about 20% of patients with venous thrombotic disease, far before ATIII, Protein C and S deficiency. Its prevalence (4% in the general belgian population, 1 to 15% in Europa) allows frequent associations with other thrombophilic disorders, inherited or acquired, such as contraceptive pill. Biological testing are now ready for screening, but the opportunity of a systematic evaluation in front of a risk situation remains a matter to discussion.
Cauchie
P
P
Laboratoire de Biologie Médicale-Hématologie CHU André Vésale, Montigny-le-Tilleul.
Hilbert
P
P
D005060:Europe / Q000453:epidemiology; D005165:Factor V / Q000235:genetics*; D015943:Factor Va / Q000037:antagonists & inhibitors*; D006801:Humans; D008403:Mass Screening; D017354:Point Mutation / Q000235:genetics*; D015995:Prevalence; D011486:Protein C / Q000502:physiology*; D012307:Risk Factors; D013927:Thrombosis / Q000453:epidemiology / Q000235:genetics* / Q000517:prevention & control
D011486:Protein C; C095381:factor V Leiden; D015943:Factor Va; D005165:Factor V