Potentiometric flow injection determination of serum bromide in patients with epilepsy.
A flow injection system was constructed using a bromide-selective electrode and used to determine serum bromide in patients with epilepsy. A 10-microliter serum sample was injected into a carrier stream flowing at 0.12 ml min-1. Potential changes and bromide concentrations were linearly related in the range 3-50 mM. The lower limit of detection for serum bromide was 1 mM and this electrode sensitivity spanned the entire concentration range required for bromide therapy (9-24 mM). The results compared favourably with those obtained by colorimetry.
Katsu
T
T
Faculty of Pharmaceutical Sciences, Okayama University, Japan.
Mori
Y
Y
Matsuka
N
N
Gomita
Y
Y
D001322:Autoanalysis; D001965:Bromides / Q000097:blood*; D016022:Case-Control Studies; D003124:Colorimetry; D003363:Cost Control; D004827:Epilepsy / Q000097:blood*; D017022:Flow Injection Analysis / Q000191:economics / Q000379:methods*; D006801:Humans; D016014:Linear Models; D017680:Potassium Compounds / Q000097:blood*; D011199:Potentiometry; D012016:Reference Values; D013997:Time Factors
D001965:Bromides; D017680:Potassium Compounds; C039004:potassium bromide