Coenzyme Q10 levels correlate with the activities of complexes I and II/III in mitochondria from parkinsonian and nonparkinsonian subjects.
The activities of complex I and complex II/III in platelet mitochondria are reduced in patients with early, untreated Parkinson's disease. Coenzyme Q10 is the electron acceptor for complex I and complex II. We found that the level of coenzyme Q10 was significantly lower in mitochondria from parkinsonian patients than in mitochondria from age- and sex-matched control subjects and that the levels of coenzyme Q10 and the activities of complex I and complex II/III were significantly correlated.
Shults
C W
CW
Neurology Service, Veterans Affairs Medical Center, San Diego, CA 92161, USA.
Haas
R H
RH
Passov
D
D
Beal
M F
MF
D001792:Blood Platelets / Q000201:enzymology; D003067:Coenzymes; D042963:Electron Transport Complex II; D014450:Electron Transport Complex III / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008928:Mitochondria / Q000201:enzymology*; D009097:Multienzyme Complexes / Q000378:metabolism*; D016660:NAD(P)H Dehydrogenase (Quinone) / Q000378:metabolism*; D010088:Oxidoreductases / Q000378:metabolism*; D010300:Parkinson Disease / Q000097:blood / Q000201:enzymology*; D012016:Reference Values; D013385:Succinate Dehydrogenase / Q000378:metabolism*; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000378:metabolism
D003067:Coenzymes; D009097:Multienzyme Complexes; D014451:Ubiquinone; D010088:Oxidoreductases; D042963:Electron Transport Complex II; D013385:Succinate Dehydrogenase; D016660:NAD(P)H Dehydrogenase (Quinone); D014450:Electron Transport Complex III; C024989:coenzyme Q10