title: Successful intracytoplasmic sperm injection with spermatozoa from a patient with dysplasia of the fibrous sheath and chronic respiratory disease.
abstract: The present report describes a successful intracytoplasmic sperm injection (ICSI) procedure performed with immotile spermatozoa from a young man with a combination of dysplasia of the fibrous sheath and dynein deficiency, a recently described variant of the immotile cilia syndrome. This methodology provides the only suitable solution for these patients in whom all other assisted fertilization technologies have previously failed, and opens the possibilities for treatment of male infertility due to severe, irreversible sperm defects such as the one reported here.
authors.affiliation: Centro de Estudios en Ginecologia y Reproduccion, Buenos Aires, Argentina.
authors.forename: S B
authors.initials: SB
authors.lastname: Olmedo
authors.forename: F
authors.initials: F
authors.lastname: Nodar
authors.forename: C
authors.initials: C
authors.lastname: Chillik
authors.forename: H E
authors.initials: HE
authors.lastname: Chemes
mesh_terms: D000328:Adult; D002908:Chronic Disease; D004398:Dyneins / Q000172:deficiency; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods*; D006801:Humans; D006965:Hyperplasia; D006984:Hypertrophy; D007248:Infertility, Male / Q000209:etiology* / Q000628:therapy*; D008297:Male; D008845:Microinjections; D011247:Pregnancy; D011256:Pregnancy Outcome; D012140:Respiratory Tract Diseases / Q000150:complications*; D013082:Sperm Tail / Q000648:ultrastructure; D013094:Spermatozoa / Q000002:abnormalities* / Q000648:ultrastructure
chemical_list: D004398:Dyneins