Engineering novel proteins by transfer of active sites to natural scaffolds.
Novel functional proteins have been generated by the transfer of active sites to structurally homologous proteins and to new structural contexts. The most successful examples of these approaches succeeded in providing effective new tools in biochemistry and protein chemistry and in suggesting new models in drug design.
Vita
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Département d'Ingénierie et d'Etudes des Protéines, CE Saclay, Gif-sur-Yvette, France. claudio.vita@cea.fr
D000818:Animals; D001665:Binding Sites; D015195:Drug Design; D006801:Humans; D008961:Models, Structural; D011487:Protein Conformation; D015202:Protein Engineering; D011994:Recombinant Proteins / Q000096:biosynthesis / Q000737:chemistry* / Q000378:metabolism; D013379:Substrate Specificity
D011994:Recombinant Proteins