title: After-cataract and ocular growth in newborn rabbit eyes implanted with a capsule tension ring.
abstract: OBJECTIVE
  To examine after-cataract and eye growth in lensectomized newborn rabbits implanted with capsule tension rings of different sizes.
  
  
  METHODS
  S:t Eriks Eye Hospital, Karolinska Institute, Stockholm, Sweden.
  
  
  METHODS
  Two groups of 24-day-old rabbits were used. In Group 1 (n = 9), lensectomy was performed in both eyes. In one randomly selected eye, an open poly(methyl methacrylate) (PMMA) capsule tension ring with a 7.0 mm diameter and 0.13 mm thickness was implanted in the capsular bag. The other eye was left aphakic. In Group 2 (n = 10), an open PMMA capsule tension ring with a 10.0 mm diameter and 0.13 mm thickness was implanted in one randomly selected eye, and the other eye was left aphakic. Axial length, corneal diameter, corneal thickness, and intraocular pressure (IOP) were measured in all eyes preoperatively and 1, 2, and 3 months after surgery. The wet mass of the after-cataract was measured at 3 months. Three Group 1 eyes and four Group 2 eyes developed secondary glaucoma and were excluded from the study.
  
  
  RESULTS
  Axial growth did not differ significantly between the eyes implanted with the 7.0 mm ring and the aphakic eyes (mean difference 0.01 mm; F3;15 = 0.02; P > .25). Corneal diameter also did not differ (two-way analysis of variance [ANOVA]). Axial length growth was less in the eyes implanted with the 10.0 mm ring than in the aphakic eyes (mean difference 1.05 mm; F3;15 = 2.06; P < .25). The average decrease in corneal diameter growth was 1.0 mm in the implanted eyes. Growth in the eyes with the 10.0 mm ring was significantly less than in the eyes with the 7.0 mm ring (P = .05, Wilcoxon rank-sum test). Corneal thickness and IOP did not differ significantly between eyes (F3;15 = 0.6; P > .25; two-way ANOVA). Amount of after-cataract did not differ significantly between the aphakic eyes and the eyes implanted with the 7.0 mm ring. It was significantly less in the eyes with the 10.0 mm ring than in those with the 7.0 mm ring (Wilcoxon signed-rank test) and in the aphakic eyes (P < .025, Wilcoxon rank-sum test).
  
  
  CONCLUSIONS
  In the young rabbit eye, a 10.0 mm capsule ring reduced the eye growth compared with both the aphakic eye and the eye implanted with a 7.0 mm ring. The 10.0 mm ring also inhibited the production of after-cataract compared with the production in the aphakic eye and the eye implanted with the 7.0 mm ring.
authors.affiliation: Department of Ophthalmology, S:t Eriks Eye Hospital/Karolinska Institute, Stockholm, Sweden.
authors.forename: U
authors.initials: U
authors.lastname: Kugelberg
authors.forename: C
authors.initials: C
authors.lastname: Zetterström
authors.forename: B
authors.initials: B
authors.lastname: Lundgren
authors.forename: S
authors.initials: S
authors.lastname: Norrby
authors.forename: S
authors.initials: S
authors.lastname: Syrén-Nordqvist
mesh_terms: D000818:Animals; D000831:Animals, Newborn / Q000254:growth & development*; D002387:Cataract Extraction; D003315:Cornea / Q000033:anatomy & histology; D005123:Eye / Q000254:growth & development*; D007903:Lens Capsule, Crystalline / Q000601:surgery*; D008768:Methylmethacrylates; D019736:Prostheses and Implants; D011817:Rabbits; D011897:Random Allocation
chemical_list: D008768:Methylmethacrylates