Effect of glucose-dependent insulinotropic polypeptide (GIP) on insulin response to glucose in acromegalics.
The pancreatic beta-cell response to stimulation with glucose and GIP, single and combined, was studied in acromegalics and in normal subjects. Acromegalics had higher IRI and GIP basal values with glucose levels and glucose disposal in the normal range. Further, acromegalics showed a greater IRI response to glucose, GIP and glucose combined with GIP. The results suggested that high growth hormone levels cause a greater activity of the entero-insular axis both in the basal state and after meal ingestion, as mimicked by GIP infusion. From these and previous observations, it can be assumed that growth hormone induces a facilitation of the IRI response to metabolite substrates and hormones.
Pierluissi
J
J
Laboratorio de Diabetología, Escuela de Medicina José María Vargas, Universidad Central de Venezuela, Caracas, Venezuela.
de Pierluissi
R M
RM
D000172:Acromegaly / Q000378:metabolism*; D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D005749:Gastric Inhibitory Polypeptide / Q000097:blood / Q000494:pharmacology*; D005947:Glucose / Q000494:pharmacology*; D019382:Human Growth Hormone / Q000097:blood; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D007515:Islets of Langerhans / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D012709:Serum Albumin / Q000494:pharmacology; D013997:Time Factors
D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D007328:Insulin; D012709:Serum Albumin; D019382:Human Growth Hormone; D005749:Gastric Inhibitory Polypeptide; D005947:Glucose