title: [Immunoglobulin E and cell-mediated hypersensitivity in an unselected adult population. The Glostrup Allergy Study].
abstract: In this study, we have assessed the relationship between immunoglobulin E-mediated and cell-mediated hypersensitivities in an unselected population living in Western Copenhagen, Denmark. A total of 793 subjects, aged 15-69 years, were studied. Measurements of serum immunoglobulin E level, prick tests with aeroallergens and patch tests with environmental haptens were performed in 561 (70.7% of 793) subjects. One or more positive prick tests were present in 28.4%, and contact sensitization occurred in 15.2%. When adjusted for the effects of age and sex, the probability of contact sensitization to one or more haptens was independent of serum immunoglobulin E level (the odds ratio value (OR)=1.0; 95% confidence interval (CI)=0.7-1.4), and the probability of contact sensitization was independent of the number of positive prick tests (OR=1.0; CI=0.8-1.2). Contact sensitization appeared to be independent of enhanced immunoglobulin E responsiveness in an unselected adult population.
authors.affiliation: Amtssygehuset i Glostrup, Københavns Amts Center for Sygdomsforebyggelse.
authors.forename: N H
authors.initials: NH
authors.lastname: Nielsen
authors.forename: T
authors.initials: T
authors.lastname: Menné
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D003718:Denmark / Q000453:epidemiology; D003877:Dermatitis, Contact / Q000453:epidemiology* / Q000276:immunology; D005260:Female; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000453:epidemiology*; D007073:Immunoglobulin E / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D010328:Patch Tests; D012882:Skin Tests
chemical_list: D007073:Immunoglobulin E