[Reproductive toxicological fundamental investigations on adult male rats of the WIST/Lppt stock on the determination of swelling after administration of cadmium chloride].
The reproductive-toxic effects after an oral administration of Cadmium as Cadmium chloride on testes and epididymidis of mature Wistar rats were investigated. After daily dosages of 0.3, 0.6, 1.0 oder 2.0 mg CdCl2/kg b.w. over one or two weeks no changes of testes and epididymidis were detected in comparison with control animals by histological observations. By means of morphometrical methods significant changes of the testes from a dosage of 1.0 mg/kg b.w. and changes of the epididymidis previously a dosage of 0.3 mg/kg b.w. have been demonstrated. That means the effect level of Cadmium is higher by consideration of testes than of epididymidis. Consequently, during investigations of reproductive toxicity one hand to test both organs.
Richter
M
M
Veterinär-Anatomisches Institut, Bereich Histologie und Embryologie, Veterinärmedizinische Fakultät, Universität Leipzig.
Schmidt
B
B
Gutte
G
G
D000818:Animals; D019256:Cadmium Chloride / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D004822:Epididymis / Q000187:drug effects / Q000473:pathology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012098:Reproduction / Q000187:drug effects*; D013737:Testis / Q000187:drug effects / Q000473:pathology*
D019256:Cadmium Chloride