[Autoantibodies to brain tissue antigens in epilepsy patients].
The observation of 38 patients with different forms of epilepsy was carried out in terms of autoantibodies (aAB) to nervous tissue proteins: p16, p30 and S-100. The pathological increase or decrease of aAB titers to at least one of the antigens (AG) mentioned above was found in 31 cases. The qualitatively new approach was further used for the revelation of aAB to S-100. Not the very protein was adsorbed on the plates for immunoenzyme assay but antiidiotypic Abs which were the "mirror reflection" of corresponding protein molecules' determinants. The authors suggested that the method permitted to estimate the level of aAB to the whole complex of AG determinants. Thus, the percent of positive tests was approximately twice higher. The index of aAB binding by corresponding anti-idiotypes was decreased in 29 patients. It's quite possible that it formed some conditions for brain tissue damages by aAB.
Morozov
S G
SG
Gnedenko
B B
BB
Asanova
L M
LM
Abramova
O S
OS
D000293:Adolescent; D000328:Adult; D000888:Antibodies, Anti-Idiotypic / Q000097:blood; D001323:Autoantibodies / Q000097:blood*; D001324:Autoantigens / Q000276:immunology*; D001921:Brain / Q000276:immunology*; D002908:Chronic Disease; D004827:Epilepsy / Q000276:immunology*; D006801:Humans; D007124:Immunoenzyme Techniques; D009419:Nerve Tissue Proteins / Q000276:immunology*; D009418:S100 Proteins / Q000276:immunology*
D000888:Antibodies, Anti-Idiotypic; D001323:Autoantibodies; D001324:Autoantigens; D009419:Nerve Tissue Proteins; D009418:S100 Proteins