title: Sarcomatoid chromophobe cell renal carcinoma: immunohistochemical and lectin study in one case.
abstract: We present one case of sarcomatoid chromophobe cell renal carcinoma with an indolent clinical course and assume that the carcinomatous component may affect the biologic behavior. The patient was a 61-year-old man who underwent right radical nephrectomy for a 11.2 cm tumor in the lower pole. The immunohistochemical findings demonstrate that EMA and cytokeratins 8 and 18 are useful markers for the sarcomatoid fraction, and the lectin study shows a loss of surface blood antigen. Chromophobe cell carcinoma may convert into sarcomatoid carcinoma. The existence of sarcomatoid renal cell carcinoma as a distinct entity should be re-considered.
authors.affiliation: Department of Anatomical Pathology, Marqués de Valdecilla University Hospital, Medical Faculty, University of Cantabria, Santander, Spain.
authors.forename: J J
authors.initials: JJ
authors.lastname: Gómez-Román
authors.forename: M
authors.initials: M
authors.lastname: Mayorga-Fernández
authors.forename: F
authors.initials: F
authors.lastname: Fernández-Fernández
authors.forename: J F
authors.initials: JF
authors.lastname: Val-Bernal
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D000368:Aged; D000954:Antigens, Surface / Q000378:metabolism; D014408:Biomarkers, Tumor / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D007633:Keratins / Q000378:metabolism; D007680:Kidney Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D037102:Lectins / Q000276:immunology / Q000378:metabolism*; D008297:Male; D018396:Mucin-1 / Q000378:metabolism; D009392:Nephrectomy; D012509:Sarcoma / Q000378:metabolism / Q000473:pathology* / Q000601:surgery
chemical_list: D000954:Antigens, Surface; D014408:Biomarkers, Tumor; D037102:Lectins; D018396:Mucin-1; D007633:Keratins