Ferrous-ascorbate complexes as carriers of nitric oxide.
Ferrous-ascorbate is known to form with nitric oxide paramagnetic nitrosyl ferrous-ascorbate complexes, Fe-AA-NO. These complexes yield on EPR signal with g-factor close to 2.02 and an optical absorption spectrum with maxima at 340, 460, and 600 nm. Fe-AA-NO complexes are unstable in the presence of oxygen. Ferrous-ascorbate complexes promote NaNO2 decay resulting in the formation of NO. Nitric oxide is taken up by Fe-AA complexes to form paramagnetic ferrous-ascorbate nitrosyl complexes, Fe-AA-NO. It is suggested that ferrous-ascorbate complexes can play the role of carriers of NO and, perhaps, O2 in the blood plasma. Nitrosyl ferrous-ascorbate complexes can also be the NO containing factor involved in the blood vessel relaxation (endothelium-derived relaxing factor, EDRF).
Kuropteva
Z V
ZV
Institute of Biochemical Physics, Russian Academy of Sciences, Moscow, Russia. chembio@glas.apc.org
Kudryavtsev
M E
ME
D001205:Ascorbic Acid / Q000378:metabolism*; D001692:Biological Transport; D004578:Electron Spin Resonance Spectroscopy; D005296:Ferrous Compounds / Q000378:metabolism*; D009569:Nitric Oxide / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000378:metabolism; D013056:Spectrophotometry, Ultraviolet
D005296:Ferrous Compounds; D017382:Reactive Oxygen Species; C051140:iron(II)-ascorbic acid complex; D009569:Nitric Oxide; D001205:Ascorbic Acid