title: Prediction of pathological tumor volume in clinically localized prostate cancer: value of endorectal coil magnetic resonance imaging.
abstract: The purpose of this study was to determine whether endorectal coil magnetic resonance imaging (MRI) enables accurate assessment of pathologic tumor volume in patients with clinically localized prostate carcinoma. Twenty-four patients with biopsy-proved prostate carcinoma underwent MRI at 0.5 T before radical prostatectomy. Tumor volumes were determined independently on axial fast-spin-echo (SE) T2-weighted MR images and whole-mount pathology slides of the surgical specimens. At pathology, tumor volumes ranged from 0.17 to 9.42 cm3 (mean +/- SD, 3.11 +/- 2.99 cm3). A strong correlation (r = .944) was found between measurements of tumor volume based on MR images and pathological specimens. The error was less than 0.5 cm3 in 14 cases, in the range of 0.5-1 cm3 in 7 cases, and more than 1 cm3 in 3 cases. By using an MR tumor volume of 2 cm3 as cutoff value, extracapsular tumor spread could be predicted with a sensitivity of 81.2%, a specificity of 100%, and an accuracy of 87.5%. Tumor volume determinations based on MR images seem to be accurate enough to be helpful in clinical decision-making.
authors.affiliation: Department of Oncology, University of Pisa, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Lencioni
authors.forename: I
authors.initials: I
authors.lastname: Menchi
authors.forename: A
authors.initials: A
authors.lastname: Paolicchi
authors.forename: M
authors.initials: M
authors.lastname: Carini
authors.forename: A
authors.initials: A
authors.lastname: Amorosi
authors.forename: C
authors.initials: C
authors.lastname: Bartolozzi
mesh_terms: D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D011237:Predictive Value of Tests; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000473:pathology* / Q000601:surgery