title: Preparation and characterization of monoclonal antibodies to foot-and-mouth disease virus type Asia-1.
abstract: Eight clones of hybrid cells secreting monoclonal antibodies to foot-and-mouth disease virus type Asia-1 were prepared; three of them neutralized viral infection. The specificity of THE monoclonal antibodies was analyzed by various immunoenzyme assays using 146S viral particles, trypsin-treated 146S particles, 12S particles, and certain viral polypeptides. The epitopes unique for virus type Asia-1 and conservative among several types were detected on the surface of viral particles. Epitopes on the surface of viral particle were mapped.
authors.affiliation: Institute of Animal Health, Russian Ministry of Agriculture and Food, Vladimir Region, Russia.
authors.forename: S P
authors.initials: SP
authors.lastname: Amineva
authors.forename: N L
authors.initials: NL
authors.lastname: Davydova
authors.forename: L U
authors.initials: LU
authors.lastname: Mamatkulova
authors.forename: L A
authors.initials: LA
authors.lastname: Globenko
authors.forename: V A
authors.initials: VA
authors.lastname: Mishchenko
mesh_terms: D000911:Antibodies, Monoclonal / Q000276:immunology*; D005537:Aphthovirus / Q000276:immunology*; D002999:Clone Cells; D004797:Enzyme-Linked Immunosorbent Assay; D018604:Epitope Mapping; D005536:Foot-and-Mouth Disease / Q000276:immunology; D009500:Neutralization Tests; D014771:Virion / Q000276:immunology
chemical_list: D000911:Antibodies, Monoclonal