title: N-acetylcysteine infusion in viral myocarditis: a case report.
abstract: N-acetylcysteine improves survival in established acute liver failure following paracetamol overdose by reducing the incidence of multiorgan failure. These benefits are thought to be related to decreased tissue hypoxia by the enhancement of both oxygen delivery and oxygen extraction. Similar findings have been recorded in critically ill patients from an alternative aetiology. The cardiovascular properties of N-acetylcysteine are to increase stroke volume index, and thus cardiac output, although there is no effect on cardiac output in normal subjects. N-acetylcysteine is known to improve myocardial contraction in a hamster model of chronic myocardial ischaemia, but such effects have not previously been described in humans. We report the beneficial circulatory effect of N-acetylcysteine in a patient with marked left ventricular dysfunction secondary to acute viral myocarditis.
authors.affiliation: Institute for Liver Studies, King's College Hospital, London, UK.
authors.forename: D S
authors.initials: DS
authors.lastname: Rowbotham
authors.forename: J A
authors.initials: JA
authors.lastname: Wendon
authors.forename: P M
authors.initials: PM
authors.lastname: Harrison
mesh_terms: D000111:Acetylcysteine / Q000008:administration & dosage* / Q000627:therapeutic use; D000914:Antibodies, Viral / Q000032:analysis; D000998:Antiviral Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D003587:Cytomegalovirus / Q000276:immunology; D003586:Cytomegalovirus Infections / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D004452:Echocardiography; D004562:Electrocardiography; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008875:Middle Aged; D009200:Myocardial Contraction / Q000187:drug effects; D009205:Myocarditis / Q000188:drug therapy* / Q000503:physiopathology / Q000821:virology
chemical_list: D000914:Antibodies, Viral; D000998:Antiviral Agents; D000111:Acetylcysteine