The diversity of coenzyme Q function.
Coenzyme Q is uniquely designed as an electron and proton carrier within the lipid phase of membranes. It now appears that this unique chemistry has diverse application to important functions in all cellular membranes. The first function of coenzyme Q was defined in the energy transduction process in mitochondria. New studies show that the presence of coenzyme Q in other cellular membranes has dynamic rather than passive significance. Coenzyme Q functions in the plasma membrane electron transport involved in activation of signalling protein kinases related to gene activation for cellular proliferation. Furthermore, the antioxidant potential of the reduced coenzyme Q is now taken on a new significance in the evidence that the reduced quinone can act to maintain tocopherol in the reduced state in membranes and ascorbate reduced both inside and outside the cell.
Crane
F L
FL
Department of Biological Science, Purdue University, West Lafayette, IN 47907, USA.
Navas
P
P
D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism; D004579:Electron Transport; D006801:Humans; D008928:Mitochondria / Q000502:physiology; D010084:Oxidation-Reduction; D010085:Oxidative Phosphorylation; D014451:Ubiquinone / Q000502:physiology*
D000975:Antioxidants; D014451:Ubiquinone