The state of antibody catalysis.
One of the fascinations of catalytic antibodies is the possibility of harnessing the mechanisms available to enzymes for chemical transformation and applying them to the broad realm of chemistry encountered in organic synthesis. Recently, the catalytic repertoire of antibodies has been extended to include mechanistically more complex bimolecular reactions and the immunological response to the hapten can be more thoroughly examined as a result of the advent of new screening technology using bacterial phages or auxotrophic cell lines.
Smithrud
D B
DB
Department of Chemistry, Pennsylvania State University, University Park 16802, USA. dbs5@psu.edu
Benkovic
S J
SJ
D000906:Antibodies / Q000378:metabolism*; D002151:Calorimetry; D002384:Catalysis; D002460:Cell Line; D006241:Haptens; D015202:Protein Engineering; D011994:Recombinant Proteins / Q000096:biosynthesis* / Q000378:metabolism
D000906:Antibodies; D006241:Haptens; D011994:Recombinant Proteins