Minimized proteins.
The design of bioactive small molecules for interaction at larger protein-protein interfaces remains a challenge. Recent progress towards minimizing proteins into significantly smaller polypeptides has been achieved via both rational design processes and selection from vast combinatorial libraries. Such 'mini-proteins' represent a potential intermediate step toward the development of drugs targeted to protein-protein interfaces.
Cunningham
B C
BC
Department of Protein Engineering, Genentech Inc., San Francisco, CA 94080, USA. bcc@gene.com
Wells
J A
JA
D000595:Amino Acid Sequence; D015195:Drug Design; D008969:Molecular Sequence Data; D010455:Peptides / Q000737:chemistry*; D013329:Structure-Activity Relationship
D010455:Peptides