title: [Selection criteria for the establishment of reference values in tropical zones. Application to specific proteins: C-reactive protein, haptoglobin, transferrin in gabonese children].
abstract: About 220 children (110 boys and 110 girls) aged 18 months to 10 years, 65.9% have been selected from anamnesis, clinical, and biological criteria to produce reference values on specific proteins dependent inflammatory, anemia and hemolysis (C-reactive protein = CRP; Transferrin = TRF and Haptoglobin: HPT). Specimens have been analysed by Nephelometric immuno-chemical method. For the two groups, A1 [18 months-5 years] and A2 [5-10 years], the reference values of the whole study population are reported: CRP (A1 3.35 +/- 3 mg/l: A2 2.40 +/- 2.30 g/l, with a significant difference at Student Fisher "t" test p < 0.03); TRF (A1 4.05 +/- 1.5 g/l; A2 4.50 +/- 1.4 g/l; NS, p > 0.05) HPT (A1 2.55 +/- 2.0 g/l: A2 1.20 +/- 1.10 g/l; S(r) p < 10(-5)). Furthermore, for TRF, HPT we must consider the sex in the results meaning because of significant difference into boys and girls.
authors.affiliation: Laboratoire de biochimie, Faculté de médecine, Libreville, Gabon.
authors.forename: E
authors.initials: E
authors.lastname: Ngou-Milama
authors.forename: J
authors.initials: J
authors.lastname: Djeki
authors.forename: S
authors.initials: S
authors.lastname: Akpona
authors.forename: D
authors.initials: D
authors.lastname: Dufillot
authors.forename: T
authors.initials: T
authors.lastname: Lebreton Devonne
authors.forename: H
authors.initials: H
authors.lastname: Mouray
mesh_terms: D000367:Age Factors; D000740:Anemia / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005681:Gabon; D006242:Haptoglobins / Q000032:analysis*; D006461:Hemolysis; D006801:Humans; D007223:Infant; D007249:Inflammation / Q000097:blood; D008297:Male; D012016:Reference Values; D015203:Reproducibility of Results; D012727:Sex Characteristics; D014168:Transferrin / Q000032:analysis*; D014330:Tropical Medicine
chemical_list: D006242:Haptoglobins; D014168:Transferrin; D002097:C-Reactive Protein