[The relationship between the high inducibility genotype of CYP450IA1 and lung cancer susceptibility].
OBJECTIVE
To evaluate the role of polymorphism of CYP450IA1 gene in the susceptibility of lung cancer.


METHODS
The polymorphism of CYP450IA1 gene in 149 lung cancer patients and 208 healthy controls were investigated by PCR technique.


RESULTS
The high inducibility genotype (Val/Val type) of CYP450IA1 in lung cancer patients was 16.1%, which was significantly higher than that of controls, 8.7%. According to pathological classification of lung cancer, it was indicated that VAl/Val type in squamous carcinomas was the highest, 21.54%, which was significantly higher than that of controls (8.7%) and adenocarcinomas (8.00%). The Val/Val type in small cell carcinoma reached 17.6%. The relative risks were estimated according to smoking condition and CYP450IA1 genotype. Taking the risk of the category with non-smoking and non-high inducibility genotype (Val/ Val) to be at a baseline of 1.0, the odds ratio was 1.6 (P < 0.05) in non-smoking in non-smoking and Val/Val type 4.8 in smoking and Val/Val type (P < 0.001). The relative risk of Val/Val type was 2.2 times as non-Val/ Val type for smoking people.


CONCLUSIONS
Development of lung cancer was associated with the high inducibility genotype of CYP450IA1. And Val/Val genotype of CYP450IA1 gene might be an important host hereditary marker for susceptibility to lung cancer.
Pi
J
J
Department of Preventive Medicine, China Medical University, Shengyang.
Sun
G
G
Lü
X
X
D000230:Adenocarcinoma / Q000235:genetics; D000368:Aged; D018288:Carcinoma, Small Cell / Q000235:genetics; D002294:Carcinoma, Squamous Cell / Q000235:genetics*; D016022:Case-Control Studies; D019363:Cytochrome P-450 CYP1A1 / Q000235:genetics*; D004198:Disease Susceptibility; D005260:Female; D005838:Genotype; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012907:Smoking / Q000009:adverse effects
D019363:Cytochrome P-450 CYP1A1