title: Efficacy of low load resistive muscle training in patients with rheumatoid arthritis functional class II and III.
abstract: OBJECTIVE
  To determine the effect of a low load resistance exercise training program on muscle strength, functional outcome, and cardiovascular endurance.
  
  
  METHODS
  Forty-nine patients, 37 women and 12 men between the ages of 35-76 yrs (mean 60.5 yrs), with definite rheumatoid arthritis (RA) functional class II and III (mean disease duration of 10.5 yrs) were randomly assigned to exercise and control groups for a 12 wk resistive muscle training program. A circuit weight bearing form of training was incorporated using light loads with high repetitions. A video tape demonstrating the exercises was given to all exercising participants to enable them to continue the program at home at least 3 times per wk with a biweekly self-report evaluation. Baseline and post-intervention evaluations included joint activity, muscle strength, endurance, functional outcome, and self-report. Cardiovascular fitness measured by treadmill time, anaerobic threshold and peak oxygen consumption (VO2) in this group were assessed at baseline and 12 wks.
  
  
  RESULTS
  A significant improvement at 12 wks was noted in the exercise group for self-reported joint count (p = 0.02), number of painful joints (p = 0.004), HAQ (p = 0.012), sit-to-stand time (p = 0.02), grip strength (p = 0.05) knee extension 60 degrees (p = 0.03), Arthritis Impact Measurement Scales dexterity (p = 0.02), and time to anaerobic threshold (p = 0.03). Significant improvement in the exercise group compared to the control group was noted for self-reported joint count (p = 0.02), night time pain (p = 0.05), and sit-to-stand time (p = 0.02). Increase in treadmill time was not statistically significant nor was a change in peak oxygen consumption (VO2) noted. Abnormalities on initial treadmill screening were detected in 2 of 49 asymptomatic patients. They were excluded from the study and subsequent workup revealed significant coronary artery disease.
  
  
  CONCLUSIONS
  Low load resistive muscle training increased functional capacity as reported by patients and is a clinically safe form of exercise in functional class II and III RA. Screening this population for dormant coronary artery disease is recommended.
authors.affiliation: Department of Internal Medicine, University of Missouri-Columbia 65212, USA.
authors.forename: G R
authors.initials: GR
authors.lastname: Komatireddy
authors.forename: R W
authors.initials: RW
authors.lastname: Leitch
authors.forename: K
authors.initials: K
authors.lastname: Cella
authors.forename: G
authors.initials: G
authors.lastname: Browning
authors.forename: M
authors.initials: M
authors.lastname: Minor
mesh_terms: D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000503:physiopathology / Q000534:rehabilitation*; D002302:Cardiac Output / Q000502:physiology; D004185:Disability Evaluation; D005081:Exercise Therapy / Q000379:methods*; D005260:Female; D006801:Humans; D007596:Joints / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000502:physiology*; D010147:Pain Measurement; D010807:Physical Endurance / Q000502:physiology; D010809:Physical Fitness; D011795:Surveys and Questionnaires