Angiotensin I converting enzyme gene polymorphism and diabetic nephropathy in type II diabetes.
BACKGROUND
The factors leading to diabetic nephropathy (DN) are not completely understood. Besides glycaemic control, genetic predisposition seems to play an important role for the development of DN. Genes of the renin-angiotensin system are potential candidate genes. An insertion/deletion polymorphism in the gene coding for the angiotensin I converting enzyme (ACE) has been extensively examined, but results were conflicting.


METHODS
We studied 658 patients with type II diabetes (n = 347 without DN, n = 311 with DN).


RESULTS
No difference was found in genotype distribution or allele frequencies between diabetic patients with and without nephropathy as defined by albumin excretion > or = 30 mg/day, but patients on dialysis had more frequently the DD-genotype.


CONCLUSIONS
Although we acknowledge certain problems in the design of the study the results in this large cohort suggest that the I/D polymorphism of the ACE gene does not play a major role in the development of DN. They are compatible, however, with a role of the gene in progression.
Schmidt
S
S
Department of Internal Medicine, Ruperto-Carola University of Heidelberg, Germany.
Ritz
E
E
D000328:Adult; D000368:Aged; D000419:Albuminuria / Q000209:etiology; D000483:Alleles; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy / Q000235:genetics*; D003928:Diabetic Nephropathies / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic
D007703:Peptidyl-Dipeptidase A