title: Cloning and chromosome assignment to 1q32 of a human cDNA (RAB7L1) encoding a small GTP-binding protein, a member of the RAS superfamily.
abstract: A full-length cDNA homologous to RAB7, a member of the RAB-related GTP-binding protein subfamily, was isolated from a human placenta cDNA library. This cDNA, designated RAB7L1, has an open reading frame of 609 nucleotides encoding 203 amino acids. Northern analysis showed that the mRNA is ubiquitously expressed in human tissues, although signal intensities were different among the various organs examined. This gene was located on chromosome band 1q32 by fluorescence in situ hybridization.
authors.affiliation: Otsuka GEN Research Institute, Otsuka Pharmaceutical Co., Ltd., Tokushima, Japan. shimizu@otsuka.genome.ad.jp
authors.forename: F
authors.initials: F
authors.lastname: Shimizu
authors.forename: T
authors.initials: T
authors.lastname: Katagiri
authors.forename: M
authors.initials: M
authors.lastname: Suzuki
authors.forename: T K
authors.initials: TK
authors.lastname: Watanabe
authors.forename: S
authors.initials: S
authors.lastname: Okuno
authors.forename: Y
authors.initials: Y
authors.lastname: Kuga
authors.forename: M
authors.initials: M
authors.lastname: Nagata
authors.forename: T
authors.initials: T
authors.lastname: Fujiwara
authors.forename: Y
authors.initials: Y
authors.lastname: Nakamura
authors.forename: E
authors.initials: E
authors.lastname: Takahashi
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics* / Q000648:ultrastructure; D003001:Cloning, Molecular; D018076:DNA, Complementary / Q000235:genetics; D004285:Dogs; D005260:Female; D019204:GTP-Binding Proteins / Q000235:genetics*; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008969:Molecular Sequence Data; D010920:Placenta / Q000378:metabolism; D011247:Pregnancy; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D051381:Rats; D017386:Sequence Homology, Amino Acid; D020691:rab GTP-Binding Proteins; D000090802:rab7 GTP-Binding Proteins
chemical_list: D018076:DNA, Complementary; D012333:RNA, Messenger; D000090802:rab7 GTP-Binding Proteins; C000716463:rab7 GTP-binding proteins, human; C000716466:rab7 GTP-binding proteins, rat; D019204:GTP-Binding Proteins; D020691:rab GTP-Binding Proteins