Effects of tenidap and nonsteroidal antiinflammatory drugs on the response of cultured human T cells to interleukin 2 in rheumatoid arthritis.
OBJECTIVE
To assess the effects of tenidap, a new oxindole class antiinflammatory compound, on the proliferative response of cultured T cells to interleukin 2 (IL-2); and to compare these effects with the antiinflammatory drugs ibuprofen, naproxen, indomethacin, piroxicam, and sulindac.


METHODS
T cells were cultured with either tenidap, ibuprofen, indomethacin, naproxen, piroxicam, or sulindac in the presence of IL-2, then assayed for incorporation of tritiated thymidine.


RESULTS
Tenidap, ibuprofen, and naproxen, at therapeutically attainable concentrations, significantly inhibited the proliferative response of T cells to IL-2. In contrast, indomethacin, piroxicam, and sulindac did not alter this response. Tenidap had a direct inhibitory effect on the response of activated T cells to IL-2. Both ibuprofen and naproxen interfered with the binding of IL-2 to T cells.


CONCLUSIONS
These results suggest variable effects of different antiinflammatory drugs on lymphocyte function that may relate to the differential effectiveness of these drugs in patients with rheumatoid arthritis.
Hall
V C
VC
Center of Excellence for Arthritis and Rheumatology, Louisiana State University Medical Center, Shreveport 71130, USA.
Wolf
R E
RE
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001172:Arthritis, Rheumatoid / Q000276:immunology*; D001665:Binding Sites / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured / Q000187:drug effects; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology*; D006801:Humans; D007211:Indoles / Q000494:pharmacology*; D007376:Interleukin-2 / Q000378:metabolism / Q000494:pharmacology*; D008213:Lymphocyte Activation / Q000187:drug effects*; D000078183:Oxindoles; D013601:T-Lymphocytes / Q000276:immunology* / Q000473:pathology
D000894:Anti-Inflammatory Agents, Non-Steroidal; D016861:Cyclooxygenase Inhibitors; D007211:Indoles; D007376:Interleukin-2; D000078183:Oxindoles; C062866:tenidap