title: Epstein-Barr virus associated B-cell lymphoma after autologous bone marrow transplantation for T-cell acute lymphoblastic leukaemia.
abstract: Epstein-Barr virus associated lymphoproliferative disease after autologous bone marrow transplantation (ABMT) has rarely been reported. We report a case of B-cell lymphoma following ABMT for T-acute lymphoblastic leukaemia; bone marrow was purged in vitro with monoclonal antibodies to remove T cells. Immunoglobulin and T-cell receptor gene rearrangement studies were used to demonstrate clonality and to show that this patient developed a second neoplasm after ABMT. EBV proteins and genome (type A) were present in post-transplantation lymphoma, suggesting a causative role in its development.
authors.affiliation: Department of Haematology, Hospital Puerta de Hierro, Universidad Autónoma de Madrid, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Briz
authors.forename: R
authors.initials: R
authors.lastname: Forés
authors.forename: C
authors.initials: C
authors.lastname: Regidor
authors.forename: M J
authors.initials: MJ
authors.lastname: Busto
authors.forename: S
authors.initials: S
authors.lastname: Ramon y Cajal
authors.forename: R
authors.initials: R
authors.lastname: Cabrera
authors.forename: J L
authors.initials: JL
authors.lastname: Díez
authors.forename: I
authors.initials: I
authors.lastname: Sanjuán
authors.forename: M N
authors.initials: MN
authors.lastname: Fernández
mesh_terms: D000368:Aged; D015139:Blotting, Southern; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D002051:Burkitt Lymphoma / Q000628:therapy*; D015326:Gene Rearrangement, B-Lymphocyte, Heavy Chain; D015329:Gene Rearrangement, T-Lymphocyte; D006566:Herpesviridae Infections / Q000150:complications*; D004854:Herpesvirus 4, Human / Q000302:isolation & purification; D006801:Humans; D016393:Lymphoma, B-Cell / Q000821:virology*; D008297:Male; D014412:Tumor Virus Infections / Q000150:complications*