title: A case of recurrent Candida parapsilosis prosthetic valve endocarditis: cure by medical treatment alone.
abstract: A patient with recurrent fungal endocarditis on prosthetic mitral valve is presented. Candida parapsilosis was the causative agent. The patient was treated medically with conventional amphotericin during the first episode. When the disease recurred conventional amphotericin B was used again, but had to be stopped because of severe side effects. Treatment was continued with amphotericin B colloidal dispersion, followed by fluconazole for 8 months. The patient is healthy 16 months after discontinuation of fluconazole. Medical treatment of fungal endocarditis on prosthetic valves can be successful in selected cases.
authors.affiliation: Department of Infectious Diseases, Medical Centre Ljubljana, Slovenia.
authors.forename: T
authors.initials: T
authors.lastname: Lejko-Zupanc
authors.forename: M
authors.initials: M
authors.lastname: Kozelj
mesh_terms: D000666:Amphotericin B / Q000627:therapeutic use*; D000935:Antifungal Agents / Q000627:therapeutic use*; D002177:Candidiasis / Q000188:drug therapy*; D004696:Endocarditis / Q000188:drug therapy* / Q000382:microbiology; D005260:Female; D015725:Fluconazole / Q000627:therapeutic use*; D006350:Heart Valve Prosthesis / Q000009:adverse effects*; D006801:Humans; D008875:Middle Aged; D016459:Prosthesis-Related Infections / Q000188:drug therapy*; D012008:Recurrence
chemical_list: D000935:Antifungal Agents; D000666:Amphotericin B; D015725:Fluconazole