Neuronal pentraxin receptor, a novel putative integral membrane pentraxin that interacts with neuronal pentraxin 1 and 2 and taipoxin-associated calcium-binding protein 49.
We have identified the first putative integral membrane pentraxin and named it neuronal pentraxin receptor (NPR). NPR is enriched by affinity chromatography on columns of a snake venom toxin, taipoxin, and columns of the taipoxin-binding proteins neuronal pentraxin 1 (NP1), neuronal pentraxin 2 (NP2), and taipoxin-associated calcium-binding protein 49 (TCBP49). The predominant form of NPR contains an putative NH2-terminal transmembrane domain and all forms of NPR are glycosylated. NPR has 49 and 48% amino acid identity to NP1 and NP2, respectively, and NPR message is expressed in neuronal regions that express NP1 and NP2. We suggest that NPR, NP1, NP2, and TCBP49 are involved in a pathway responsible for the transport of taipoxin into synapses and that this may represent a novel neuronal uptake pathway involved in the clearance of synaptic debris.
Dodds
D C
DC
Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA.
Omeis
I A
IA
Cushman
S J
SJ
Helms
J A
JA
Perin
M S
MS
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002097:C-Reactive Protein / Q000737:chemistry* / Q000378:metabolism*; D002135:Calcium-Binding Proteins / Q000378:metabolism*; D002846:Chromatography, Affinity; D004546:Elapid Venoms / Q000378:metabolism*; D017403:In Situ Hybridization; D017038:Mannosyl-Glycoprotein Endo-beta-N-Acetylglucosaminidase / Q000378:metabolism; D008562:Membrane Glycoproteins / Q000235:genetics / Q000302:isolation & purification* / Q000378:metabolism; D008969:Molecular Sequence Data; D008970:Molecular Weight; D009419:Nerve Tissue Proteins / Q000737:chemistry* / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D011956:Receptors, Cell Surface / Q000235:genetics / Q000302:isolation & purification* / Q000378:metabolism; D016415:Sequence Alignment; D000099153:Pentraxins
D002097:C-Reactive Protein; D002135:Calcium-Binding Proteins; D004546:Elapid Venoms; D017038:Mannosyl-Glycoprotein Endo-beta-N-Acetylglucosaminidase; D008562:Membrane Glycoproteins; D009419:Nerve Tissue Proteins; D012333:RNA, Messenger; D011956:Receptors, Cell Surface; D000099153:Pentraxins; C107687:neuronal pentraxin receptor; C093202:taipoxin-associated calcium-binding protein 49; C015523:taipoxin