Autosomal dominant familial Parkinson disease: older onset of age, and good response to levodopa therapy.
Autosomal dominant Parkinson's disease in 5 generations of a family living in Sagamihara City is reported. Clinical features of this family did not differ from common PD, however, neuropathological findings were different from PD. In autopsied cases, the loss of melanin-containing cells was mild to moderate, and the number of neurons of the locus ceruleus was maintained. No Lewy bodies were detected at all from any region where Lewy bodies frequently appear in PD.
Hasegawa
K
K
Department of Neurology, Kitasato University School of Medicine, Kanagawa, Japan.
Kowa
H
H
D000328:Adult; D017668:Age of Onset; D000978:Antiparkinson Agents / Q000627:therapeutic use*; D005260:Female; D005799:Genes, Dominant; D006801:Humans; D007980:Levodopa / Q000627:therapeutic use*; D008875:Middle Aged; D010300:Parkinson Disease / Q000188:drug therapy / Q000235:genetics*; D010375:Pedigree; D016896:Treatment Outcome
D000978:Antiparkinson Agents; D007980:Levodopa