title: Keeping calcium in its place: Ca(2+)-ATPase and phospholamban.
abstract: Electron microscopy is gradually revealing more and more about the structure of the calcium pump from the sarcoplasmic reticulum, Ca(2+)-ATPase. The most recent result reveals the ATP-binding site, and two different avenues are being pursued towards achieving a higher resolution structure. Although no such structures are currently available for phospholamban, various spectroscopies and site-directed mutagenesis have been combined to produce a compelling structural model for its regulation of Ca(2+)-ATPase.
authors.affiliation: Skirball Institute for Biomolecular Medicine, New York University Medical Center, New York, NY 10012, USA. stokes@saturn.med.nyu.edu
authors.forename: D L
authors.initials: DL
authors.lastname: Stokes
mesh_terms: D001665:Binding Sites; D002118:Calcium; D002135:Calcium-Binding Proteins / Q000737:chemistry*; D000252:Calcium-Transporting ATPases / Q000737:chemistry / Q000648:ultrastructure*; D003460:Crystallization; D018360:Crystallography, X-Ray; D000099211:Phospholamban
chemical_list: D002118:Calcium; D002135:Calcium-Binding Proteins; D000252:Calcium-Transporting ATPases; D000099211:Phospholamban