[The effect of local hyperthermia on NK activity and lung metastasis in mice].
OBJECTIVE
To study the effects of local hyperthermia on primary and metastatic focus.


METHODS
Animal tumor model was established in C57BL/6 mouse by injecting 5 x 10(5) Lewis lung carcinoma cells into the left foot pad. Ten days later, a tumor mass of 10 x 10 mm was seen, and local hyperthermia was performed at 37, 43, 45 and 47 degrees C for 30 minutes with water bath. 96 mice were randomly divided into four groups of 1, 2, 3, 4 weeks according to time of sacrifice. Every group had 6 mice.


RESULTS
NK activity increased after 43-45 degrees C hyperthermia, and was higher than that of the control group (37 degrees C). The growth rate and lung metastasis decreased.


CONCLUSIONS
Host immunity is thought to be enhanced by local hyperthermia and plays an important role in eradicating primary tumor and controlling distant metastasis.
Hu
Y
Y
General Hospital of PLA, Beijing.
Wang
J
J
Lu
S
S
D000818:Animals; D018827:Carcinoma, Lewis Lung / Q000276:immunology* / Q000628:therapy*; D005260:Female; D005528:Foot; D006979:Hyperthermia, Induced; D007694:Killer Cells, Natural / Q000276:immunology*; D008175:Lung Neoplasms / Q000556:secondary*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009368:Neoplasm Transplantation; D011897:Random Allocation