title: A burn wound healing model in the hairless descendant of the Mexican hairless dog.
abstract: Wound contraction and epithelialization occur much faster in animals than in humans. Therefore it is sometimes not valid to apply the results of animal wound healing studies to humans. Hairless descendants of Mexican hairless dogs (HD-MHD) have attracted attention because their skin characteristics approximate those of humans. We used this animal and compared the rate of healing of superficial dermal burns (SDB) and deep dermal burns (DDB) in the HD-MHD and normal beagles. We also compared the rate of healing with use of Vaseline (Chesebrough-Ponds) gauze (VG) and hydrocolloid dressings in the HD-MHD. The HD-MHD demonstrated less contraction (p < 0.05). Small pigmented spots could be seen in the HD-MHD wounds, suggesting that epithelialization started from epidermal appendages. SDBs treated with VG and hydrocolloid dressings were both epithelialized on day 18. DDBs treated with hydrocolloid dressings were epithelialized on day 24, whereas DDBs treated with VG were epithelialized on day 30. Like human wounds, burns in the HD-MHD epithelialize from appendages with less wound contraction. These similarities support the use of this burn wound healing model.
authors.affiliation: Department of Plastic Surgery, Tokyo Medical College, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Matsumura
authors.forename: N
authors.initials: N
authors.lastname: Yoshizawa
authors.forename: T
authors.initials: T
authors.lastname: Kimura
authors.forename: K
authors.initials: K
authors.lastname: Watanabe
authors.forename: N S
authors.initials: NS
authors.lastname: Gibran
authors.forename: L H
authors.initials: LH
authors.lastname: Engrav
mesh_terms: D000818:Animals; D002056:Burns / Q000503:physiopathology*; D004195:Disease Models, Animal; D004285:Dogs; D004727:Endothelium / Q000166:cytology / Q000378:metabolism; D005260:Female; D012867:Skin / Q000293:injuries*; D014945:Wound Healing / Q000502:physiology*