title: [Conservative treatment of gastroduodenal peptic ulcer perforations: indications and results].
abstract: Surgery is the conventional form of treatment for perforated peptic ulcer. Conservative treatment has however been described, and is still used in rare situations. The present study analyzes the indications and results of conservative therapy in our hospital. Between 1978 and 1995, 332 patients were admitted for perforated peptic ulcer. Twelve (3.5%), with a mean age of 85 (67-93) years, underwent conservative treatment (gastric suction, H2-blockers and broad-spectrum antibiotics). The diagnosis was established on the basis of epigastric pain and the finding of a pleuriperitoneum on the plain film of the abdomen. The indication for conservative treatment was a prohibitive anesthesiological risk in 11 patients and absence of peritoneal sign in one. The evolution was favourable only in 4 patients, who were discharged after a median stay of 18 days. Mortality was 8/12 patients. In one of these, autopsy showed ischemic colonic perforation. Conservative treatment of perforated peptic ulcer is associated with very high mortality. The results suggest that frequent and careful clinical monitoring is essential during the first 24 hours. In the event of deterioration, surgery must be reconsidered. In addition, the diagnosis should be confirmed by ruling out perforation of another abdominal organ.
authors.affiliation: Département de chirurgie, Hôpitaux universitaires de Genève.
authors.forename: N
authors.initials: N
authors.lastname: Alizadeh
authors.forename: L
authors.initials: L
authors.lastname: Bühler
authors.forename: O
authors.initials: O
authors.lastname: Huber
authors.forename: P
authors.initials: P
authors.lastname: Morel
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D004381:Duodenal Ulcer / Q000188:drug therapy* / Q000401:mortality; D005260:Female; D006635:Histamine H2 Antagonists / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D010439:Peptic Ulcer Perforation / Q000188:drug therapy* / Q000401:mortality; D013276:Stomach Ulcer / Q000188:drug therapy* / Q000401:mortality; D015996:Survival Rate
chemical_list: D000900:Anti-Bacterial Agents; D006635:Histamine H2 Antagonists