title: [beta-blocker in hypertension].
abstract: The beta-blockers are either nonselective and affect both beta 1- and beta 2-receptors, are relatively selective for the alpha 1 subclass, or are able to have activity against alpha-receptors. The ability to reduce blood pressure is very common among all beta-blockers, and beta-blockers are recommended for one of the first-line drugs in hypertension treatment by JNCV. beta-blockers should be used considering their pharmacological properties and potential side effects, according to the pathophysiological conditions involved. The superiority of beta-blocker to other types of antihypertensive drug has not yet been evidenced by larger scale clinical trials which have been carried out so far. To verify more precisely the usefulness of beta-blocker in hypertension treatment, more large scale clinical trials are required to be carried out. The fixed-dose combination of beta-blockers and calcium blockers appears to be more effective rather than that of beta-blockers and diuretics.
authors.affiliation: Tohoku University School of Medicine.
authors.forename: K
authors.initials: K
authors.lastname: Takeuchi
authors.forename: N
authors.initials: N
authors.lastname: Nushiro
authors.forename: K
authors.initials: K
authors.lastname: Tsunoda
authors.forename: K
authors.initials: K
authors.lastname: Abe
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000737:chemistry / Q000145:classification / Q000494:pharmacology; D000595:Amino Acid Sequence; D002986:Clinical Trials as Topic; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008969:Molecular Sequence Data; D011943:Receptors, Adrenergic, beta / Q000187:drug effects / Q000378:metabolism
chemical_list: D000319:Adrenergic beta-Antagonists; D011943:Receptors, Adrenergic, beta