Simultaneous identification of campylobacters and prediction of quinolone resistance by comparative sequence analysis.
Comparative sequence analysis of a 30-bp segment in the quinolone resistance-determining region of campylobacters not only allows for the detection of base changes associated with resistance but also is a powerful tool for species identification based on silent mutations.
Husmann
M
M
Institute for Medical Microbiology and Hygiene, Johannes-Gutenberg-University Mainz, Germany.
Feddersen
A
A
Steitz
A
A
Freytag
C
C
Bhakdi
S
S
D042462:4-Quinolones; D000890:Anti-Infective Agents / Q000494:pharmacology*; D002167:Campylobacter / Q000187:drug effects* / Q000235:genetics*; D027081:DNA Gyrase; D004250:DNA Topoisomerases, Type II / Q000235:genetics*; D004269:DNA, Bacterial / Q000032:analysis*; D004352:Drug Resistance, Microbial / Q000235:genetics; D016133:Polymerase Chain Reaction; D016415:Sequence Alignment; D017422:Sequence Analysis, DNA; D017386:Sequence Homology, Amino Acid; D013045:Species Specificity
D042462:4-Quinolones; D000890:Anti-Infective Agents; D004269:DNA, Bacterial; D027081:DNA Gyrase; D004250:DNA Topoisomerases, Type II