Age-related changes of platelet arachidonic acid metabolism in normal subjects.
Platelet activation and thrombosis play a crucial role in cardiovascular diseases. It has been suggested that enhanced platelet function in vivo are present in the elderly and that they are associated with the development of these diseases [1-3]. In the present study, we addressed the question of whether platelet arachidonate metabolism was altered with aging.
Tomo
K
K
Takayama
H
H
Okuma
M
M
D019377:12-Hydroxy-5,8,10,14-eicosatetraenoic Acid / Q000096:biosynthesis / Q000097:blood; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000097:blood*; D001092:Arachidonate 12-Lipoxygenase / Q000097:blood; D016718:Arachidonic Acid / Q000097:blood*; D001792:Blood Platelets / Q000378:metabolism*; D006801:Humans; D015539:Platelet Activation; D013929:Thromboxane B2 / Q000096:biosynthesis / Q000097:blood
D016718:Arachidonic Acid; D013929:Thromboxane B2; D019377:12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; D001092:Arachidonate 12-Lipoxygenase