Oxidation of remnant-like particles from serum of diabetic patients, patients with ischemic heart disease and normal subjects.
Remnant-like particles (RLP) are reportedly involved in the pathogenesis of atherosclerosis, as are lipid peroxides. To assess the role of the oxidation of RLP in this disease, we compared the oxidation of RLP with that of total very low density lipoproteins (VLDL) obtained from the serum of 10 patients with ischemic heart disease (IHD), 10 patients with diabetes mellitus (DM) and 10 normal subjects by measuring the levels of thiobarbituric acid reactive substances (TBARS). Our results indicated that RLP were oxidized in vivo to a greater extent than total VLDL in all three groups of subjects. The serum levels of RLP were significantly higher in the patients than in the normal subjects. The oxidation of RLP may therefore be involved in the progression of atherosclerosis in patients with IHD or DM.
Tamura
M
M
Third Department of Internal Medicine, Tokyo Medical and Dental University, Japan.
Tanaka
A
A
Yui
K
K
Nakajima
K
K
Numano
F
F
D000328:Adult; D000368:Aged; D002914:Chylomicrons / Q000097:blood*; D003324:Coronary Artery Disease / Q000097:blood / Q000175:diagnosis; D003327:Coronary Disease / Q000097:blood* / Q000175:diagnosis; D003920:Diabetes Mellitus / Q000097:blood* / Q000175:diagnosis; D005260:Female; D006801:Humans; D008054:Lipid Peroxides / Q000097:blood; D008079:Lipoproteins, VLDL / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010084:Oxidation-Reduction; D012016:Reference Values; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
D002914:Chylomicrons; D008054:Lipid Peroxides; D008079:Lipoproteins, VLDL; D017392:Thiobarbituric Acid Reactive Substances