Kips off to Myc: implications for TGF beta signaling.
Loss of sensitivity to the negative growth regulator transforming growth factor beta (TGF beta) is a feature of many different tumor types and is likely involved in tumor progression. In some cases this loss of sensitivity to TGF beta has been shown to be manifest in the absence of membrane-associated TGF beta receptor complexes, thus preventing initiation of antiproliferative signals from the cell surface. In others, loss of sensitivity to TGF beta-induced inhibitory signals has been attributed to loss of function of intracellular effectors of TGF beta-induced inhibitory signals due to mutation or allelic loss of effector genes and their products. The intracellular effectors of TGF beta inhibitory signals have been shown to be involved in the normal regulation of progression through the cell cycle, specifically during G1 phase. In this manner, elucidation of the mechanisms by which TGF beta inhibits cell growth not only helps us identify steps involved in tumor progression, but also allows us to better understand how cells regulate progression through the cell cycle.
Alexandrow
M G
MG
Department of Cell Biology and Vanderbilt Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA.
Moses
H L
HL
D018844:Cyclin-Dependent Kinases / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D016193:G1 Phase / Q000502:physiology; D006801:Humans; D016271:Proto-Oncogene Proteins c-myc / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology; D016212:Transforming Growth Factor beta / Q000378:metabolism
D016271:Proto-Oncogene Proteins c-myc; D016212:Transforming Growth Factor beta; D018844:Cyclin-Dependent Kinases