title: Urinary excretion of ethylenethiourea in five volunteers on a controlled diet (multicentric study).
abstract: Urinary excretion of ethylenethiourea (ETU) was monitored for 8 days in a group of five male non-smoker volunteers on a diet, the items of which were assayed for ETU and carbon sulphide. Urinary excretion of ETU reflected the consumption of wine, fruit and vegetables. Urinary ETU concentrations ranged from 0.6 to 6.7 micrograms/g creatinine. ETU concentrations in the food eaten by the volunteers were generally below the detection limit whereas in wine 8.8 micrograms/l ETU was detected. Evolution of carbon sulphide by food samples ranged from 0.03 to 0.17 mg/kg. Mean (+/- S.D.) daily intake of ETU in wine was 3.5 +/- 0.2% of the acceptable daily intake (ADI): 0.070 +/- 0.004 micrograms/kg body wt. During the 8 days of the study, an average of 48.3% of the ETU ingested in wine was excreted unmodified by the kidneys. Twenty-four hour urinary excretion of ETU was significantly correlated with daily intake of ETU (r = 0.768) and CS2 evolved by the daily food items (r = 0.414).
authors.affiliation: Institute of Occupational Medicine, Siena University, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Aprea
authors.forename: A
authors.initials: A
authors.lastname: Betta
authors.forename: G
authors.initials: G
authors.lastname: Catenacci
authors.forename: A
authors.initials: A
authors.lastname: Colli
authors.forename: A
authors.initials: A
authors.lastname: Lotti
authors.forename: C
authors.initials: C
authors.lastname: Minoia
authors.forename: P
authors.initials: P
authors.lastname: Olivieri
authors.forename: V
authors.initials: V
authors.lastname: Passini
authors.forename: I
authors.initials: I
authors.lastname: Pavan
authors.forename: C
authors.initials: C
authors.lastname: Roggi
authors.forename: R
authors.initials: R
authors.lastname: Ruggeri
authors.forename: G
authors.initials: G
authors.lastname: Sciarra
authors.forename: R
authors.initials: R
authors.lastname: Turci
authors.forename: P
authors.initials: P
authors.lastname: Vannini
authors.forename: V
authors.initials: V
authors.lastname: Vitalone
mesh_terms: D000328:Adult; D002244:Carbon / Q000652:urine*; D017554:Carbon Compounds, Inorganic; D002851:Chromatography, High Pressure Liquid; D004032:Diet; D004435:Eating / Q000502:physiology; D005031:Ethylenethiourea / Q000032:analysis / Q000378:metabolism*; D005504:Food Analysis / Q000592:standards; D005638:Fruit / Q000737:chemistry; D006801:Humans; D016014:Linear Models; D008297:Male; D012015:Reference Standards; D013440:Sulfides / Q000652:urine*; D014556:Urine / Q000737:chemistry; D014675:Vegetables / Q000737:chemistry; D014920:Wine / Q000032:analysis
chemical_list: D017554:Carbon Compounds, Inorganic; D013440:Sulfides; D005031:Ethylenethiourea; C092035:carbon sulfide; D002244:Carbon