[Impact of mycobacteria on nonspecific protective mechanisms associated with exchange of organic sulphur and nitrogen].
Guinea-pig experiments indicated that Mycobacteria tuberculosis (MBT) were actively involved in detoxification of the xenobiotics polycyclic aromatic hydrocarbons (PAH) and substantially altered the nonspecific protective mechanisms associated with activation of the body's antioxidative resources. MBT in the lung and liver tissues of animals long preexposed to PAH elevated the concentrations of sulphur-containing amino acids and glutathione with consumption of abundant nitrogen-rich adaptogenic antioxidants (arginine, urea) accumulated under the action of PAH. At the same time there is a upward trend for the body's antioxidative potentials both in a group infected with MBT and in group receiving PAH. Supplementing sodium glutamate potentiated the revealed adaptive rearrangements.
Pavlov
V A
VA
Ural NII Phthisiopulmonology, Department of Health of RF, Ekaterinburg.
D000818:Animals; D004195:Disease Models, Animal; D006168:Guinea Pigs; D015227:Lipid Peroxidation; D008099:Liver / Q000378:metabolism* / Q000382:microbiology; D008168:Lung / Q000378:metabolism* / Q000382:microbiology; D009169:Mycobacterium tuberculosis / Q000378:metabolism*; D017672:Nitrogen Compounds / Q000378:metabolism*; D011084:Polycyclic Aromatic Hydrocarbons / Q000633:toxicity; D011897:Random Allocation; D013455:Sulfur / Q000378:metabolism*; D014397:Tuberculosis, Pulmonary / Q000378:metabolism; D015262:Xenobiotics / Q000633:toxicity
D017672:Nitrogen Compounds; D011084:Polycyclic Aromatic Hydrocarbons; D015262:Xenobiotics; D013455:Sulfur