Point: status of lipid and lipoprotein standardization.
Cholesterol and triglyceride standardization procedures have been used extensively and continuously since the 1950s. Definitive and Reference Methods, as well as primary and secondary standards, have been developed and maintained as the basis for evaluating the accuracy of results by various methods in many laboratories. But, although standardization efforts for apolipoprotein A-I and B measurements have been reported in detail in the scientific literature, much less has been reported in the area of total and lipoprotein cholesterol and triglyceride standardization efforts. Standardized cholesterol and triglyceride concentrations, determined in multiple large epidemiological and clinical studies, have been instrumental to the National Cholesterol Education Program panels that have assessed the lipoprotein values associated with risk of coronary disease, and have determined the cutpoints that are now used extensively by physicians to guide diagnosis and treatment of individual patients.
McNamara
J R
JR
Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA. mcnamara_li@hnrc.tufts.edu
Leary
E T
ET
Ceriotti
F
F
Boersma-Cobbaert
C M
CM
Cole
T G
TG
Hassemer
D J
DJ
Nakamura
M
M
Packard
C J
CJ
Seccombe
D W
DW
Kimberly
M M
MM
Myers
G L
GL
Cooper
G R
GR
D001053:Apolipoproteins / Q000097:blood; D001774:Blood Chemical Analysis / Q000592:standards*; D002487:Centers for Disease Control and Prevention, U.S.; D002784:Cholesterol / Q000097:blood*; D003327:Coronary Disease / Q000097:blood; D006801:Humans; D008055:Lipids / Q000097:blood*; D008074:Lipoproteins / Q000097:blood*; D009316:National Institutes of Health (U.S.); D012015:Reference Standards; D012016:Reference Values; D012307:Risk Factors; D012958:Societies, Scientific; D014280:Triglycerides / Q000097:blood*; D014481:United States; D014944:World Health Organization
D001053:Apolipoproteins; D008055:Lipids; D008074:Lipoproteins; D014280:Triglycerides; D002784:Cholesterol