title: Nutritional value of succinic acid monoethyl ester in starvation.
abstract: Rats were fasted for 48 h, but infused with either NaCl or the sodium salt of monoethyl succinic acid (EMS), both delivered at a rate of 80 mumol/g body weight per day. The infusion of EMS, as compared to NaCl, failed to affect paraovarian adipose tissue or liver weight, liver or muscle glycogen, and insulinemia. It accentuated the starvation-induced fall in body weight, and decreased both liver and muscle protein content. Nevertheless, the succinate ester increased plasma D-glucose concentration, delayed the rise in ketonemia, maintained a higher glucokinase/hexokinase activity ratio in liver and pancreatic islets, and allowed for a more efficient stimulation of insulin release by D-glucose or 2-ketoisocaproate in isolated pancreatic islets. These findings indicate that monoethyl succinate displays a significant nutritional value when infused in starved rats.
authors.affiliation: Laboratory of Experimental Medicine, Brussels Free University, Belgium.
authors.forename: L
authors.initials: L
authors.lastname: Ladrière
authors.forename: W J
authors.initials: WJ
authors.lastname: Malaisse
mesh_terms: D020155:3-Hydroxybutyric Acid; D000273:Adipose Tissue / Q000187:drug effects; D000818:Animals; D001786:Blood Glucose / Q000032:analysis / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects / Q000502:physiology; D005260:Female; D005941:Glucokinase / Q000032:analysis / Q000378:metabolism; D006593:Hexokinase / Q000032:analysis / Q000378:metabolism; D006885:Hydroxybutyrates / Q000097:blood / Q000378:metabolism; D007328:Insulin / Q000032:analysis / Q000097:blood / Q000378:metabolism; D007515:Islets of Langerhans / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism; D008099:Liver / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism; D018482:Muscle, Skeletal / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism; D009753:Nutritive Value; D051381:Rats; D017208:Rats, Wistar; D012965:Sodium Chloride / Q000494:pharmacology / Q000592:standards; D013217:Starvation / Q000378:metabolism* / Q000503:physiopathology*; D013386:Succinates / Q000494:pharmacology / Q000592:standards*; D013997:Time Factors
chemical_list: D001786:Blood Glucose; D006885:Hydroxybutyrates; D007328:Insulin; D013386:Succinates; D012965:Sodium Chloride; D006593:Hexokinase; D005941:Glucokinase; D020155:3-Hydroxybutyric Acid; C041105:monomethyl succinate