Calcium homeostasis influences epidermal sweating in patients with vitiligo.
Patients with vitiligo have a decreased sweating response in both their lesional and non-lesional skin (n = 17) compared with healthy age- and sex-matched controls (n = 22) after stimulation with the acetylcholine agonist pilocarpine. The decreased cholinergic response of the dermal sweat glands in this patient group correlates with a significantly lower calcium concentration in sweat compared with controls. In addition, a significantly higher potassium concentration was found in the pigmented skin of these patients. The other fast exchange ions sodium and chloride are unaffected. In vitiligo, there was a marginal sweat induction after adrenergic stimulation in four of 10 patients tested whereas all controls (n = 10) did not show any response.
Elwary
S M
SM
Department of Biomedical Sciences, University of Bradford, U.K.
Headley
K
K
Schallreuter
K U
KU
D000109:Acetylcholine / Q000819:agonists; D000293:Adolescent; D000328:Adult; D000368:Aged; D002118:Calcium / Q000378:metabolism*; D002712:Chlorides / Q000378:metabolism; D004817:Epidermis / Q000378:metabolism / Q000503:physiopathology*; D005260:Female; D006706:Homeostasis; D006801:Humans; D007478:Iontophoresis; D008297:Male; D008875:Middle Aged; D018721:Muscarinic Agonists; D010862:Pilocarpine; D011188:Potassium / Q000378:metabolism; D012964:Sodium / Q000378:metabolism; D013268:Stimulation, Chemical; D013546:Sweating / Q000187:drug effects*; D014820:Vitiligo / Q000378:metabolism / Q000503:physiopathology*
D002712:Chlorides; D018721:Muscarinic Agonists; D010862:Pilocarpine; D012964:Sodium; D000109:Acetylcholine; D011188:Potassium; D002118:Calcium