Retinoic acid as a therapy for emphysema?
In concert with its action as a morphogen during embryonal development, retinoic acid appears to be able to regenerate lung alveoli in an experimental model of elastase-induced emphysema in rats, thereby inhibiting manifestation of the disease. The application to humans is now an interesting possibility.
DeLuca
L M
LM
Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, MD 20892-4255, USA.
Ross
S A
SA
D000818:Animals; D004646:Emphysema / Q000139:chemically induced / Q000188:drug therapy*; D006801:Humans; D010196:Pancreatic Elastase; D051381:Rats; D014212:Tretinoin / Q000627:therapeutic use*
D014212:Tretinoin; D010196:Pancreatic Elastase