The Epstein-Barr virus in malignant non-Hodgkin's lymphoma of the upper aerodigestive tract.
Sixty malignant non-Hodgkin's lymphomas originating in the upper aerodigestive tract have been analyzed for their cytologic type, immunophenotype and association with the Epstein-Barr virus (EBV). The majority of these tumors were B-cell lymphomas of blastic cytology (78%) with the exception of lymphomas in the parotid gland. Large B-cell lymphomas were the most frequent encountered in the sinonasal region and Waldeyer's ring. Twelve lymphomas were of T- or T/NK (natural killer)-cell lineage. They were in the nasal cavity and the paranasal sinuses (4), the tonsil (5), and the oral cavity (3). Epstein-Barr sequences were detected in five angiocentric T/NK-lymphomas, one peripheral T-cell lymphoma, one lymphoma of lymphomatoid granulomatosis type, one large B-cell lymphoma, and in a lymphoroliferative disorder in an HIV-positive patient. These results suggest that EBV is not involved in lymphomagenesis of B-cell tumors, but is associated with angiocentric T/NK-cell lymphoma in the upper aerodigestive tract.
Ott
G
G
Department of Pathology, University of Würzburg, Federal Republic of Germany.
Kalla
J
J
Ott
M M
MM
Müller-Hermelink
H K
HK
D015139:Blotting, Southern; D006258:Head and Neck Neoplasms / Q000473:pathology / Q000821:virology*; D006566:Herpesviridae Infections / Q000473:pathology*; D004854:Herpesvirus 4, Human / Q000302:isolation & purification*; D006801:Humans; D016130:Immunophenotyping; D017403:In Situ Hybridization; D008228:Lymphoma, Non-Hodgkin / Q000473:pathology / Q000821:virology*; D014412:Tumor Virus Infections / Q000473:pathology*