"Cutis tricolor": congenital hyper- and hypopigmented macules associated with a sporadic multisystem birth defect: an unusual example of twin spotting?
An uncommon coexistence of circumscribed hyperpigmentation and hypopigmentation, in close proximity to each other, is described in a 17 years old patient with various other cogenital defects, such as dysmorphic facial appearance, severe kyphoscoliosis, delayed motor development, epileptic seizures, and mental retardation. We suggest the combination of hyper- and hypopigmented cutaneous lesions is an example of allelic twin spotting. Because the skin of this patient showed three different degrees of pigmentation the term "cutis tricolor" is proposed.
Happle
R
R
Department of Dermatology, University of Marburg, Germany.
Barbi
G
G
Eckert
D
D
Kennerknecht
I
I
D000015:Abnormalities, Multiple / Q000473:pathology*; D000293:Adolescent; D000483:Alleles; D006801:Humans; D017495:Hyperpigmentation / Q000151:congenital* / Q000473:pathology; D017496:Hypopigmentation / Q000151:congenital* / Q000473:pathology; D008297:Male; D012867:Skin / Q000473:pathology