title: Effects of ethyl alpha-D-glucoside on skin barrier disruption.
abstract: Daily treatments of skin in hairless mice with concentrates of rice wine, Japanese traditional alcohol, lowered transepidermal water loss levels compared to the controls on the 3rd day after ultraviolet B (UVB) irradiation. These findings indicate that the concentrates of rice wine suppress the murine skin barrier disruption caused by UVB. Ethyl alpha-D-glucoside (alpha-ethylglucoside), one of the peculiar components in rice wine, showed the same effect, whereas beta-ethylglucoside had no effect. In order to clarify the functions of alpha-ethylglucoside on murine skin, we examined the effects of this compound on the expression of some phenotypes in human keratinocytes in vitro. As a result, alpha-ethylglucoside as well as beta-ethylglucoside enhanced cell proliferation weakly, and the formation of cornified envelopes and differentiated type keratin (K1) in keratinocytes was accelerated by alpha-ethylglucoside but not by beta-ethylglucoside. From the results, we conclude that alpha-ethylglucoside enhanced the differentiation of keratinocytes, which might be related to reduced barrier disruption by UVB.
authors.affiliation: Basic Research Laboratory, Kanebo Ltd., Kanagawa-ken, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Kitamura
authors.forename: Y
authors.initials: Y
authors.lastname: Ota
authors.forename: A
authors.initials: A
authors.lastname: Haratake
authors.forename: T
authors.initials: T
authors.lastname: Ikemoto
authors.forename: O
authors.initials: O
authors.lastname: Tanno
authors.forename: T
authors.initials: T
authors.lastname: Horikoshi
mesh_terms: D000434:Alcoholic Beverages; D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D005960:Glucosides / Q000494:pharmacology*; D006801:Humans; D015603:Keratinocytes / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D007633:Keratins / Q000096:biosynthesis; D008297:Male; D051379:Mice; D008812:Mice, Hairless; D012275:Oryza; D012867:Skin / Q000166:cytology / Q000187:drug effects* / Q000528:radiation effects; D014466:Ultraviolet Rays; D014870:Water Loss, Insensible / Q000187:drug effects / Q000528:radiation effects
chemical_list: D005960:Glucosides; D007633:Keratins; C108400:ethyl glucoside