title: A randomized trial to assess once-daily topical treatment of tinea corporis with butenafine, a new antifungal agent.
abstract: BACKGROUND
  Tinea corporis treatment usually requires topical application of an antifungal agent for 2 to 3 weeks.
  
  
  OBJECTIVE
  We evaluated short-term treatment of tinea corporis with butenafine hydrochloride, a new benzylamine with in vitro fungicidal activity.
  
  
  METHODS
  Patients (n = 78) were randomly selected to apply butenafine or its cream vehicle alone once daily for 14 days and were periodically assessed until day 42.
  
  
  RESULTS
  Butenafine recipients had significantly higher rates of mycologic cure beginning at day 7 (64% vs 9%) with continued improvements through day 42 (88% vs 17%). They also had higher rates of effective treatment (mycologic cure and 90% to 100% symptom improvement) at day 7 (33% vs 0%) with increasing rates through day 42 (81% vs 14%).
  
  
  CONCLUSIONS
  Butenafine provides rapid and persistent antifungal activity and symptom relief in patients with tinea corporis. Significant effects were observed within 7 days of therapy initiation, and increasing effectiveness was observed 4 weeks after therapy.
authors.affiliation: Department of Dermatology, Louisiana State University Medical Center, New Orleans 70112, USA.
authors.forename: D L
authors.initials: DL
authors.lastname: Greer
authors.forename: J
authors.initials: J
authors.lastname: Weiss
authors.forename: D A
authors.initials: DA
authors.lastname: Rodriguez
authors.forename: A A
authors.initials: AA
authors.lastname: Hebert
authors.forename: J M
authors.initials: JM
authors.lastname: Swinehart
mesh_terms: D000279:Administration, Cutaneous; D000293:Adolescent; D000328:Adult; D000935:Antifungal Agents / Q000008:administration & dosage* / Q000009:adverse effects; D001596:Benzylamines / Q000008:administration & dosage* / Q000009:adverse effects; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D009281:Naphthalenes / Q000008:administration & dosage* / Q000009:adverse effects; D009824:Ointments; D014005:Tinea / Q000188:drug therapy*
chemical_list: D000935:Antifungal Agents; D001596:Benzylamines; D009281:Naphthalenes; D009824:Ointments; C067594:butenafine