Thrombocytopenia in dogs with anticoagulant rodenticide-induced hemorrhage: eight cases (1990-1995).
Thrombocytopenia was documented in eight of 11 dogs with anticoagulant rodenticide-induced hemorrhage. Thrombocytopenia was transient and generally mild-to-moderate, but it became marked (i.e., less than 30,000 platelets/microl) in two cases. Petechial hemorrhages were not noted in any case. There was no relationship between hematocrit and platelet count. Platelet count changes in response to treatment with fresh-frozen plasma and isotonic electrolyte solutions were variable. Anticoagulant rodenticide toxicity should be included as a differential diagnosis for dogs with hemorrhage accompanied by mild-to-moderate thrombocytopenia.
Lewis
D C
DC
Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan 66506-5606, USA.
Bruyette
D S
DS
Kellerman
D L
DL
Smith
S A
SA
D000818:Animals; D000925:Anticoagulants / Q000506:poisoning*; D001798:Blood Proteins / Q000627:therapeutic use; D003937:Diagnosis, Differential; D004283:Dog Diseases / Q000097:blood / Q000139:chemically induced / Q000209:etiology*; D004285:Dogs; D006400:Hematocrit; D006470:Hemorrhage / Q000139:chemically induced / Q000150:complications / Q000662:veterinary*; D007074:Immunoglobulin G / Q000097:blood; D007552:Isotonic Solutions / Q000627:therapeutic use; D010976:Platelet Count; D011041:Poisoning / Q000150:complications / Q000662:veterinary; D012378:Rodenticides / Q000506:poisoning*; D013921:Thrombocytopenia / Q000175:diagnosis / Q000209:etiology / Q000662:veterinary*
D000925:Anticoagulants; D001798:Blood Proteins; D007074:Immunoglobulin G; D007552:Isotonic Solutions; D012378:Rodenticides