title: [Prognostic implication of DNA contents on long-term outcome of childhood acute lymphoblastic leukemia].
abstract: Prognostic value of cellular DNA content was evaluated in 189 children with acute lymphoblastic leukemia. Treatment outcome of the three different DNA index (DI) groups (Group A, DI = 1.0 vs. Group B, DI 1.01-1.15 vs. Group C, DI > or = 1.16) was compared between the two treatment risk groups (standard-risk and high-risk groups) stratified by the initial leukocyte count and age. In the standard-risk group, these groups had 10-year event free survival (EFS) rate (SE) of 62% (6%), 40% (21%) and 87% (6%), respectively (p < 0.05). In the high risk group, they had 10-year EFS rate of 30% (5%), 33% (27%) and 60% (19%), respectively (p < 0.01). Use of the DI, leukocyte count and age may be sufficient to distinguish the patients with an extremely low risk of failing to the standard ALL therapy from the patients with a relatively high-risk of treatment failure.
authors.affiliation: Department of Pediatrics, Aichi Medical University.
authors.forename: M
authors.initials: M
authors.lastname: Tsurusawa
authors.forename: N
authors.initials: N
authors.lastname: Katano
authors.forename: M
authors.initials: M
authors.lastname: Aoyama
authors.forename: T
authors.initials: T
authors.lastname: Fujimoto
authors.forename: K
authors.initials: K
authors.lastname: Nishikawa
authors.forename: Y
authors.initials: Y
authors.lastname: Hatae
authors.forename: M
authors.initials: M
authors.lastname: Miyake
authors.forename: K
authors.initials: K
authors.lastname: Kawakami
authors.forename: T
authors.initials: T
authors.lastname: Furuyama
authors.forename: A
authors.initials: A
authors.lastname: Iwai
authors.forename: Y
authors.initials: Y
authors.lastname: Horikoshi
mesh_terms: D002648:Child; D002675:Child, Preschool; D004273:DNA, Neoplasm / Q000032:analysis*; D006801:Humans; D007223:Infant; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000401:mortality*; D011379:Prognosis; D015996:Survival Rate; D017211:Treatment Failure
chemical_list: D004273:DNA, Neoplasm