title: Effects of various types of Triton X on the susceptibilities of methicillin-resistant staphylococci to oxacillin.
abstract: We examined the effect of six types of the nonionic detergent Triton X on the susceptibilities of methicillin-resistant staphylococci to oxacillin. We used five methicillin-resistant Staphylococcus aureus isolates and 17 methicillin-resistant coagulase-negative staphylococci isolates. All strains of S. aureus, S. epidermidis and S. sciuri had enhanced susceptibility to oxacillin following exposure to the types of Triton X having 7-13 polymerized ethylene oxides. These strains were altered from homogeneously resistant to heterogeneously resistant by Triton X-100. Those types of Triton X that affected the resistance level also promoted the release of lipoteichoic acid. These results and those of previous studies suggest that Triton X might act on factors other than the mecA or femA products.
authors.affiliation: Department of Pediatric Dentistry, Hiroshima University, School of Dentistry, Japan.
authors.forename: J
authors.initials: J
authors.lastname: Suzuki
authors.forename: H
authors.initials: H
authors.lastname: Komatsuzawa
authors.forename: M
authors.initials: M
authors.lastname: Sugai
authors.forename: K
authors.initials: K
authors.lastname: Ohta
authors.forename: K
authors.initials: K
authors.lastname: Kozai
authors.forename: N
authors.initials: N
authors.lastname: Nagasaka
authors.forename: H
authors.initials: H
authors.lastname: Suginaka
mesh_terms: D003902:Detergents / Q000737:chemistry / Q000494:pharmacology*; D016106:Methicillin Resistance; D017830:Octoxynol / Q000737:chemistry / Q000494:pharmacology*; D010068:Oxacillin / Q000494:pharmacology*; D010406:Penicillins / Q000494:pharmacology*; D013210:Staphylococcus / Q000187:drug effects*
chemical_list: D003902:Detergents; D010406:Penicillins; D017830:Octoxynol; D010068:Oxacillin