Effect and mechanisms of the anti-prolactin drug cabergoline on pseudopregnancy in the bitch.
A potent anti-prolactin drug, cabergoline, administered orally for five days, was clinically successful in treating three different clinical manifestations of pseudopregnancy in referred bitches. The clinical conditions treated were categorised as standard pseudopregnant bitches (n = 8), those previously unsuccessfully treated with hormones (n = 10) and those which had behavioural pseudopregnancy following ovariohysterectomy (n = 8). The number of bitches whose owners reported a 'good' response was seven out of eight, six out of 10 and six out of eight, respectively. There were very few side effects in that only one bitch vomited following treatment. The clinical response did not necessarily appear to be related to an alteration in circulating prolactin concentrations, suggesting that the drug may have a direct effect on the tissues as well as in most cases reducing the plasma prolactin concentrations.
Harvey
M J
MJ
Department of Veterinary Clinical Studies, University of Glasgow Veterinary School, Bearsden.
Cauvin
A
A
Dale
M
M
Lindley
S
S
Ballabio
R
R
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology; D000077465:Cabergoline; D004283:Dog Diseases / Q000188:drug therapy* / Q000503:physiopathology; D004285:Dogs; D018491:Dopamine Agonists / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004873:Ergolines / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D007044:Hysterectomy / Q000379:methods / Q000662:veterinary; D010052:Ovariectomy / Q000379:methods / Q000662:veterinary; D011374:Progesterone / Q000097:blood; D011388:Prolactin / Q000037:antagonists & inhibitors* / Q000097:blood; D011555:Pseudopregnancy / Q000188:drug therapy / Q000503:physiopathology / Q000662:veterinary*
D018491:Dopamine Agonists; D004873:Ergolines; D011374:Progesterone; D011388:Prolactin; D000077465:Cabergoline