title: Latissimus dorsi flap procedures to cover myelomeningocele in utero: a feasibility study in human fetuses.
abstract: There is experimental and clinical evidence that in utero repair of myelomeningocele (MMC) may preserve neurological function. In five aborted human fetuses (gestational age, 18 to 29 weeks), the authors tested whether proximally and distally based latissimus dorsi flaps (LDF) can be used to cover MMC lesions. Fetal soft tissues were developed enough to allow surgical handling, preparation of both flap types was technically easy, and the vascular pedicles could be preserved. The proximally pedicled LDF was suitable to cover the upper spine from lower cervical to lower thoracic levels, whereas the distally pedicled LDF was suitable to cover the spine between lower thoracic and lower sacral levels. These results suggest that various LDF procedures are technically feasible in early gestational human fetuses and could be used for in utero repair of MMC.
authors.affiliation: Department of Surgery, University Children's Hospital, Zurich, Switzerland.
authors.forename: C
authors.initials: C
authors.lastname: Meuli-Simmen
authors.forename: M
authors.initials: M
authors.lastname: Meuli
authors.forename: N S
authors.initials: NS
authors.lastname: Adzick
authors.forename: M R
authors.initials: MR
authors.lastname: Harrison
mesh_terms: D001415:Back; D005240:Feasibility Studies; D005333:Fetus / Q000601:surgery*; D006801:Humans; D008591:Meningomyelocele / Q000601:surgery*; D013524:Surgical Flaps