Skeletal functions of vitamin K-dependent proteins: not just for clotting anymore.
Osteocalcin and matrix Gla protein (MGP) are two vitamin K-dependent proteins present in bone and cartilage. Transgenic mice models were recently developed to isolate the function of each of these proteins. While osteocalcin-deficient mice have increased bone formation, MGP-deficient mice have abnormal calcification leading to osteopenia, fractures, and premature death owing to arterial calcification.
Booth
S L
SL
Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA.
D000818:Animals; D001842:Bone and Bones / Q000502:physiology*; D002135:Calcium-Binding Proteins / Q000172:deficiency / Q000502:physiology*; D016326:Extracellular Matrix Proteins; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic; D015675:Osteocalcin / Q000172:deficiency / Q000502:physiology*; D014812:Vitamin K / Q000502:physiology*; D000097568:Matrix Gla Protein
D002135:Calcium-Binding Proteins; D016326:Extracellular Matrix Proteins; D015675:Osteocalcin; D014812:Vitamin K; D000097568:Matrix Gla Protein