Applications of PET in diabetes research.
Use of positron emission tomography (PET) combined with 18F-fluoro-2-deoxy-D-glucose (18FDG) allows a noninvasive quantitation of glucose uptake in individual tissues such as human muscles and heart. Using 15O-labelled water and 18FDG the role of blood flow as a regulator of glucose metabolism can be studied with PET. PET has allowed study of the factors regulating heart glucose uptake in normal subjects and in subjects with alterations in skeletal muscle insulin sensitivity, and has provided evidence that insulin stimulated rates of blood flow and glucose uptake do not co-localize within muscle tissues.
Nuutila
P
P
Department of Medicine, University of Turku, Finland. pirjo.nuutila@utu.fi
D001786:Blood Glucose / Q000378:metabolism*; D019788:Fluorodeoxyglucose F18 / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000097:blood; D018482:Muscle, Skeletal / Q000000981:diagnostic imaging / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism*; D014055:Tomography, Emission-Computed
D001786:Blood Glucose; D007328:Insulin; D019788:Fluorodeoxyglucose F18