title: Association between thrombolytic treatment and the prognosis of hemodynamically stable patients with major pulmonary embolism: results of a multicenter registry.
abstract: BACKGROUND
  Thrombolytic treatment has been shown to accelerate resolution of major pulmonary embolism and lead to a rapid improvement of right-side hemodynamics. However, the association between these favorable effects and the clinical outcome of patients who have no severe hemodynamic compromise at presentation remains unknown.
  
  
  RESULTS
  The present multicenter registry included 719 consecutive patients with major pulmonary embolism according to clinical, echocardiographic, scintigraphic, and cardiac catheterization criteria. Symptom onset was acute (<48 hours) in 63% of patients. All patients were hemodynamically stable (ie, without evidence of cardiogenic shock) at presentation. Primary thrombolytic treatment (within 24 hours of diagnosis) was given to 169 patients (23.5%), whereas the remaining 550 patients were initially treated with heparin alone. Overall 30-day mortality was significantly lower in the patients who received thrombolytic agents (4.7 versus 11.1%, P=.016). Clinical factors associated with a higher death rate were syncope (P=.012), arterial hypotension (P=.021), history of congestive heart failure (P=.013), and chronic pulmonary disease (P=.032). However, only primary thrombolysis was found by multivariate analysis to be an independent predictor of survival (odds ratio for in-hospital death, 0.46; 95% confidence interval, 0.21 to 1.00). Patients who underwent early thrombolytic treatment had a reduced rate of recurrent pulmonary embolism (7.7 versus 18.7%, P<.001) but also a higher frequency of major bleeding episodes (21.9% versus 7.8%, P<.001). Cerebral bleeding occurred in 2 patients in each treatment group, and 1 patient in each group died of a bleeding complication.
  
  
  CONCLUSIONS
  The results of our study suggest that thrombolysis may favorably affect the clinical outcome of hemodynamically stable patients with major pulmonary embolism.
authors.affiliation: Abteilung Innere Medizin III-Kardiologie, Freiburg, Germany. mol@imbi.uni-freiburg.de
authors.forename: S
authors.initials: S
authors.lastname: Konstantinides
authors.forename: A
authors.initials: A
authors.lastname: Geibel
authors.forename: M
authors.initials: M
authors.lastname: Olschewski
authors.forename: F
authors.initials: F
authors.lastname: Heinrich
authors.forename: K
authors.initials: K
authors.lastname: Grosser
authors.forename: K
authors.initials: K
authors.lastname: Rauber
authors.forename: S
authors.initials: S
authors.lastname: Iversen
authors.forename: M
authors.initials: M
authors.lastname: Redecker
authors.forename: J
authors.initials: J
authors.lastname: Kienast
authors.forename: H
authors.initials: H
authors.lastname: Just
authors.forename: W
authors.initials: W
authors.lastname: Kasper
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004452:Echocardiography; D005260:Female; D005343:Fibrinolytic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D006439:Hemodynamics; D006470:Hemorrhage / Q000139:chemically induced; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011655:Pulmonary Embolism / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000503:physiopathology*; D012008:Recurrence; D012042:Registries; D016019:Survival Analysis; D013997:Time Factors
chemical_list: D005343:Fibrinolytic Agents