[Level and significance of the soluble interleukin-2 receptor expression in serum of patients with bladder cancer].
The results of a dynamic study of the soluble interleukin-2 receptor (SIL-2R) expression, interleukin-2 (IL-2) production and natural killer cell factor (NKCF) activity before and after operation in 24 bladder carcinoma patients were reported. The SIL-2R expression level in the patients was significantly higher, the IL-2 production and NKCF activity were remarkably lower than those of controls. Furthermore, the higher the stage of the tumor, the higher the level of the SIL-2R. There was a period of immune suppression after operation. The results suggest that the changes of the SIL-2R expression level, IL-2 production and NKCF activity are closely related to the prognosis of patients with bladder carcinoma.
Wen
R
R
Department of Urology, Affiliated Hospital of Xuzhou Medical College.
Xie
S
S
Ma
P
P
D000368:Aged; D002295:Carcinoma, Transitional Cell / Q000276:immunology* / Q000473:pathology; D005260:Female; D006801:Humans; D018664:Interleukin-12 / Q000378:metabolism; D007376:Interleukin-2 / Q000096:biosynthesis; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D015375:Receptors, Interleukin-2 / Q000097:blood*; D001749:Urinary Bladder Neoplasms / Q000276:immunology* / Q000473:pathology
D007376:Interleukin-2; D015375:Receptors, Interleukin-2; D018664:Interleukin-12