Pyrethroid decrease in central nervous system from nerve agent pretreatment.
We studied the effect of pyridostigmine bromide, a nerve agent prophylactic, on the central nervous system (CNS) uptake of [14C]permethrin, a pyrethroid insecticide, at scaled human-equivalent exposures in rats using accelerator mass spectrometry (AMS). AMS detects 14C at attomole sensitivities and determines the tissue distribution of 14C-labeled compounds. Pyridostigmine bromide in chow at 7.75 mg kg(-1) per day lowered the CNS tissue levels of permethrin, dosed at 4.75 microg kg(-1), in the CNS of rats by 30%. These results are inconsistent with hypothesized synergy of such compounds as a precursor to 'Gulf War syndrome'.
Buchholz
B A
BA
Lawrence Livermore National Laboratory, CA 94551, USA.
Pawley
N H
NH
Vogel
J S
JS
Mauthe
R J
RJ
D000818:Animals; D002250:Carbon Radioisotopes; D002490:Central Nervous System / Q000378:metabolism*; D002800:Cholinesterase Inhibitors / Q000494:pharmacology*; D007306:Insecticides / Q000493:pharmacokinetics*; D008297:Male; D026023:Permethrin; D011722:Pyrethrins / Q000493:pharmacokinetics*; D011729:Pyridostigmine Bromide / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014018:Tissue Distribution
D002250:Carbon Radioisotopes; D002800:Cholinesterase Inhibitors; D007306:Insecticides; D011722:Pyrethrins; D026023:Permethrin; D011729:Pyridostigmine Bromide