title: Pulmonary airway reopening: effects of non-Newtonian fluid viscosity.
abstract: This paper considers the effects of non-Newtonian lining-fluid viscosity, particularly shear thinning and yield stress, on the reopening of the airways. The airway was simulated by a very thin, circular polyethylene tube, which collapsed into a ribbon-like configuration. The non-Newtonian fluid viscosity was described by the power-law and Herschel-Buckley models. The speed of airway opening was determined under various opening pressures. These results were collapsed into dimensionless pressure-velocity relationships, based on an assumed shear rate gamma = U/(0.5 H), where U and H are the opening velocity and fluid film thickness, respectively. It was found that yield stress, like surface tension, increases the yield pressure and opening time. However, shear thinning reduces the opening time. An increased film thickness of the non-Newtonian lining fluid generally impedes airway reopening; a higher pressure is needed to initiate the airway reopening and a longer time is required to complete the opening process.
authors.affiliation: Department of Mechanical & Production Engineering, National University of Singapore, Singapore.
authors.forename: H T
authors.initials: HT
authors.lastname: Low
authors.forename: Y T
authors.initials: YT
authors.lastname: Chew
authors.forename: C W
authors.initials: CW
authors.lastname: Zhou
mesh_terms: D000403:Airway Resistance / Q000502:physiology*; D001980:Bronchi / Q000378:metabolism / Q000503:physiopathology; D004548:Elasticity; D008954:Models, Biological; D009093:Mucus / Q000378:metabolism; D012212:Rheology; D013314:Stress, Mechanical; D013500:Surface Tension; D014132:Trachea / Q000503:physiopathology; D014783:Viscosity