title: Presence of inflammatory mediators in the tears of contact lens wearers and non-contact lens wearers.
abstract: The present studies have demonstrated the levels of N-methyl histamine in tears from normal physiological states, pathological states and contact lens wear. Histamine was significantly increased in closed eye tears compared with both open and reflex tears. Tears from other ocular conditions had low levels of histamine except for environmental hypersensitivity, which contained significantly elevated levels compared to normal tear types. Interestingly, tears from asymptomatic contact lens wearers had significant levels of histamine whereas tears from contact lens adverse events had lower levels, possibly reflecting a change in histamine metabolism.
authors.affiliation: Cooperative Research Centre for Eye Research and Technology, University of New South Wales, Sydney, Australia.
authors.forename: M
authors.initials: M
authors.lastname: Tan
authors.forename: A
authors.initials: A
authors.lastname: Thakur
authors.forename: C
authors.initials: C
authors.lastname: Morris
authors.forename: M D
authors.initials: MD
authors.lastname: Willcox
mesh_terms: D000704:Analysis of Variance; D003233:Conjunctivitis, Allergic / Q000209:etiology / Q000378:metabolism* / Q000628:therapy; D003261:Contact Lenses; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism*; D015850:Interleukin-6 / Q000378:metabolism; D007634:Keratitis / Q000209:etiology / Q000378:metabolism* / Q000628:therapy; D007975:Leukotriene B4 / Q000378:metabolism; D008761:Methylhistamines / Q000378:metabolism; D013666:Tears / Q000378:metabolism*
chemical_list: D018836:Inflammation Mediators; D015850:Interleukin-6; D008761:Methylhistamines; D007975:Leukotriene B4; C048140:N-methylhistamine