Complementary oligonucleotides and the origin of the mammalian involucrin gene.
A large portion of the consensus sequence of four mammalian involucrin genes comprises four pairs of complementary oligonucleotides. One of the oligonucleotides in each pair is rich in purines and the other in pyrimidines. The perfect complementarity of a number of pairs apparently resulted from a concerted single nucleotide substitution in each pairing oligonucleotide from their respective consensus. This suggests that one member of the pair was derived from the other member of the same pair by a template-dependent replication mechanism. Such a replication mechanism differs from the one that creates tandem repeats by producing short complementary sequence on the same strand of DNA.
Tseng
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School of Medicine, University of Pennsylvania, Department of Dermatology, Philadelphia, USA. htsengpe@mail.med.upenn.edu
D000595:Amino Acid Sequence; D000818:Animals; D016645:Aotidae; D001483:Base Sequence; D003062:Codon / Q000235:genetics; D016384:Consensus Sequence; D004261:DNA Replication; D004285:Dogs; D007900:Lemur; D008322:Mammals / Q000235:genetics*; D051379:Mice; D008969:Molecular Sequence Data; D017354:Point Mutation; D011498:Protein Precursors / Q000096:biosynthesis / Q000737:chemistry / Q000235:genetics*; D011687:Purines; D011743:Pyrimidines; D012091:Repetitive Sequences, Nucleic Acid; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D012689:Sequence Homology, Nucleic Acid; D013552:Swine
D003062:Codon; D011498:Protein Precursors; D011687:Purines; D011743:Pyrimidines; C032253:involucrin