Chromatin-silencing mechanisms in Drosophila maintain patterns of gene expression.
The Polycomb-Group proteins form chromatin complexes that can silence gene expression over large distances. The formation of these complexes at homeotic genes depends on early developmental events but the repressed state is then maintained through many cell divisions. In vivo, complexes formed at one genomic site can interact with those at other sites, suggesting that they, like heterochromatin complexes, affect the folding of chromatin and the organization of chromosomes in the nucleus.
Pirrotta
V
V
Department of Zoology, University of Geneva, Switzerland. pirrotta@sc2a.unige.ch
D000818:Animals; D002843:Chromatin / Q000235:genetics*; D004268:DNA-Binding Proteins / Q000235:genetics; D004330:Drosophila / Q000235:genetics*; D029721:Drosophila Proteins; D018507:Gene Expression Regulation, Developmental; D018398:Homeodomain Proteins / Q000235:genetics; D019476:Insect Proteins / Q000235:genetics*; D008957:Models, Genetic; D063150:Polycomb Repressive Complex 1; D012097:Repressor Proteins / Q000235:genetics; D014157:Transcription Factors
D002843:Chromatin; D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; D018398:Homeodomain Proteins; D019476:Insect Proteins; C066770:Pc protein, Drosophila; D012097:Repressor Proteins; D014157:Transcription Factors; C063460:Trl protein, Drosophila; C066177:Ubx protein, Drosophila; D063150:Polycomb Repressive Complex 1