Necrotizing cutaneous lesions caused by interferon beta injections in a patient with multiple sclerosis.
We report a patient with multiple sclerosis who was receiving subcutaneous injections of recombinant interferon beta. During the third month of treatment, painful necrotizing cutaneous lesions appeared at the injection sites. The possible pathogenesis of interferon-induced skin necrosis is discussed.
Feldmann
R
R
Department of Dermatology, Krankenhaus der Stadt Wien-Lainz, Austria.
Löw-Weiser
H
H
Duschet
P
P
Gschnait
F
F
D000276:Adjuvants, Immunologic / Q000008:administration & dosage / Q000009:adverse effects*; D000328:Adult; D004890:Erythema / Q000209:etiology; D005260:Female; D006801:Humans; D007279:Injections, Subcutaneous; D016899:Interferon-beta / Q000008:administration & dosage / Q000009:adverse effects*; D009103:Multiple Sclerosis / Q000628:therapy*; D009336:Necrosis; D011994:Recombinant Proteins; D012867:Skin / Q000473:pathology*
D000276:Adjuvants, Immunologic; D011994:Recombinant Proteins; D016899:Interferon-beta