Role of Btk in B cell development and signaling.
Bruton's tyrosine kinase (Btk), the target of inactivating mutations in X-linked immunodeficiency diseases of mice and humans, is essential for normal B cell responsiveness. Recent studies have outlined a mechanism for the activation of Btk by B cell receptor engagement and have identified proximal and distal targets of Btk action.
Desiderio
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Department of Molecular Biology and Genetics, Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. steve_desiderio@qmail.bs.jhu.edu
D000077329:Agammaglobulinaemia Tyrosine Kinase; D000818:Animals; D000955:Antigens, T-Independent / Q000276:immunology; D001402:B-Lymphocytes / Q000166:cytology* / Q000201:enzymology; D002454:Cell Differentiation; D004789:Enzyme Activation; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000201:enzymology* / Q000235:genetics / Q000276:immunology; D051379:Mice; D008817:Mice, Mutant Strains; D010766:Phosphorylation; D011499:Protein Processing, Post-Translational; D011505:Protein-Tyrosine Kinases / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*; D014960:X Chromosome / Q000235:genetics; D019061:src-Family Kinases / Q000502:physiology
D000955:Antigens, T-Independent; D011505:Protein-Tyrosine Kinases; D000077329:Agammaglobulinaemia Tyrosine Kinase; C000625949:BTK protein, human; C000625951:Btk protein, mouse; D019061:src-Family Kinases