title: [Fetal uropathies: anatomo-pathologic background].
abstract: The kidney malformations are complex anatomo-clinical entities that can be described with different classification approaches, based on morphological or etiopathogenetic criteria. The most serious fetal uropathies can be associated with the oligohydramnios sequence, due to insufficient urine escretion, related, for example to bilateral renal agenesis. A second malformation sequence can also be present, the so-called prune belly syndrome, in which an early urethral obstruction can produce abnormal bladder distension and finally renal dysplasia and globous dilation of the abdomen. The anatomo-pathological experience of the last ten years in the Institute of Pathological Anatomy of the University of Bari is based upon 154 cases of congenital uropathies in second trimester fetuses. Almost 80% of these cases presented also other associated anomalies, both chromosomal and non chromosomal syndromic or in casual combination. The possible echographic recognition of these pathologies, together with genetic and anatomopathological studies allow to categorize the fetal uropathies in two groups: the first characterized by an early or late obstruction of the urinary tract, in "sensu strictu" the true obstructive uropathies, and the second, formed by different morphologies all genetically determined.
authors.affiliation: Istituto di Anatomia Patologica, Università di Bari.
authors.forename: G
authors.initials: G
authors.lastname: Caruso
authors.forename: A
authors.initials: A
authors.lastname: Pece
authors.forename: M A
authors.initials: MA
authors.lastname: Botticella
authors.forename: A
authors.initials: A
authors.lastname: Caniglia
mesh_terms: D005260:Female; D005315:Fetal Diseases / Q000473:pathology*; D006801:Humans; D007674:Kidney Diseases / Q000473:pathology*; D011247:Pregnancy; D014551:Urinary Tract / Q000196:embryology* / Q000473:pathology*