Genetic variation in the VP7 gene of human rotavirus serotype 3 (G3 type) isolated in China and Japan.
Sequence analysis of the VP7 gene was performed on twenty-one human isolates of serotype 3 related-rotavirus in China and Japan. The five Chinese isolates were found to be not similar to the 16 Japanese isolates and to SA11 (simian rotavirus). The Chinese isolates, especially CHW2 and CH-32, were different from the major serotype 3 human isolates. AU-1 and 02/92 which previously showed a wider spacing between RNA segments 10 and 11 by RNA polyacrylamide gel electrophoretic analysis, were more closely related to each other and could be differentiated from the other Chinese and Japanese isolates. For these reasons, serotype 3 viruses were considered to be intraserotypically more heterologous than serotype 1, 2 and 4 viruses.
Wen
L
L
Department of Maternal and Child Health, Faculty of Medicine, University of Tokyo, Japan.
Nakayama
M
M
Yamanishi
Y
Y
Nishio
O
O
Fang
Z Y
ZY
Nakagomi
O
O
Araki
K
K
Nishimura
S
S
Hasegawa
A
A
Müller
W E
WE
Ushijima
H
H
D000595:Amino Acid Sequence; D000956:Antigens, Viral; D001483:Base Sequence; D002213:Capsid / Q000235:genetics*; D036022:Capsid Proteins; D002648:Child; D002681:China; D005759:Gastroenteritis / Q000821:virology; D005814:Genes, Viral; D014644:Genetic Variation; D006801:Humans; D007564:Japan; D008969:Molecular Sequence Data; D012401:Rotavirus / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification; D012400:Rotavirus Infections / Q000821:virology; D017386:Sequence Homology, Amino Acid; D012689:Sequence Homology, Nucleic Acid; D012703:Serotyping
D000956:Antigens, Viral; D036022:Capsid Proteins; C050779:VP7 protein, Rotavirus