title: The interactive language of the hypothalamus for the gonadotropin releasing hormone (GNRH) system.
abstract: The enormous diversity in neurochemical signals employed within the network of afferents to GnRH neurons is well-documented. An examination of novel and accumulating knowledge on the operation of these messengers indicates the presence of an interactive language governing GnRH secretion. The basic operational structures identified to date to affirm this interactive form of communication summarized in this review are the following: (i) the demonstration of interconnections within various components of the afferent network; (ii) coexistence and possible co-release of excitatory and inhibitory neurotransmitters/neuromodulators; (iii) co-action of various messengers at synaptic targets, and (4) modulation by gonadal steroids of the synthesis and release of signals and their receptors, and induction of synaptic plasticity for the timely relay of signals for GnRH secretion. Unraveling the molecular sequelae that promote this interactive communication to elicit periodic GnRH secretion is now a new challenge.
authors.affiliation: Department of Neuroscience, University of Florida College of Medicine, Gainesville 32610, USA. Skalra@neocortex.health.UFL.edu
authors.forename: S P
authors.initials: SP
authors.lastname: Kalra
authors.forename: T
authors.initials: T
authors.lastname: Horvath
authors.forename: F
authors.initials: F
authors.lastname: Naftolin
authors.forename: B
authors.initials: B
authors.lastname: Xu
authors.forename: S
authors.initials: S
authors.lastname: Pu
authors.forename: P S
authors.initials: PS
authors.lastname: Kalra
mesh_terms: D000344:Afferent Pathways / Q000502:physiology; D000818:Animals; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000502:physiology*; D006801:Humans; D007031:Hypothalamus / Q000502:physiology*; D008297:Male; D018377:Neurotransmitter Agents / Q000378:metabolism
chemical_list: D018377:Neurotransmitter Agents; D007987:Gonadotropin-Releasing Hormone