Effect of age on P300 wave.
30 healthy elderly males (mean age 77.4 +/- 4.3 yrs) were subjects in this study. Equal number of young males (mean age 22 +/- 3.5 years) and middle aged subjects (mean age 46 +/- 3.2 years) served as control. P300 wave was estimated using a Neuropack 4 model of Nihon Kohden EMG machine. We observed a significantly increased latency, poorly defined and non reproducible P300 wave in 90% old subjects while in young the latency was in normal limits and the wave was well defined and reproducible. We presume P300 could serve as a future potential marker of the neurophysiological basis of aging.
Jha
S
S
Department of Neurology, King George's College, Lucknow.
Shukla
R
R
Nag
D
D
Kar
A M
AM
Agarwal
A
A
D000161:Acoustic Stimulation; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D004576:Electromyography / Q000295:instrumentation; D018913:Event-Related Potentials, P300 / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009482:Neurophysiology; D011930:Reaction Time / Q000502:physiology; D015203:Reproducibility of Results; D012815:Signal Processing, Computer-Assisted