Erythromelalgia: a pathognomonic microvascular thrombotic complication in essential thrombocythemia and polycythemia vera.
Erythromelalgia is a characteristic thrombotic complication in patients with the myeloproliferative disorders, essential thrombocythemia and polycythemia vera. In this minireview, which is based on more than 20 years of clinical observations and intervention studies, the clinical manifestations, treatment, and pathogenesis of erythromelalgia are discussed.
van Genderen
P J
PJ
Department of Internal Medicine II and Hematology, Erasmus University Hospital Dijkzigt, Rotterdam, The Netherlands.
Michiels
J J
JJ
D001792:Blood Platelets / Q000378:metabolism; D016861:Cyclooxygenase Inhibitors / Q000627:therapeutic use; D004730:Endothelium, Vascular / Q000473:pathology; D004916:Erythromelalgia / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D005121:Extremities / Q000098:blood supply; D006801:Humans; D007093:Imidazoles / Q000627:therapeutic use; D015539:Platelet Activation; D011087:Polycythemia Vera / Q000150:complications*; D013817:Thermography; D013920:Thrombocythemia, Essential / Q000150:complications*
D016861:Cyclooxygenase Inhibitors; D007093:Imidazoles; C029166:dazoxiben