title: MR566A and MR566B, new melanin synthesis inhibitors produced by Trichoderma harzianum. II. Physico-chemical properties and structural elucidation.
abstract: New melanin synthesis inhibitors (MR566A and B) and six related known isocyanocyclopentenes were isolated from the fermentation broth of Trichoderma harzianum, and their structures were elucidated by spectroscopic methods. The structures of novel isocyanides, MR566A (1) and B (2), were elucidated as 1-(3-chloro-1,2-dihydroxy-4-isocyano-4-cyclopenten-1-yl)etha nol, 1-(1,2,3-trihydroxy-3-isocyano-4-cyclopenten-1-yl)ethanol, respectively. The structure of novel oxazole, MR93B (9), was elucidated as 4-[(1Z)-3-hydroxy-2-hydroxymethyl-1-propen-1-yl]oxazole.
authors.affiliation: Korea Research Institute of Bioscience & Biotechnology, Taejon.
authors.forename: C H
authors.initials: CH
authors.lastname: Lee
authors.forename: H
authors.initials: H
authors.lastname: Koshino
authors.forename: M C
authors.initials: MC
authors.lastname: Chung
authors.forename: H J
authors.initials: HJ
authors.lastname: Lee
authors.forename: J K
authors.initials: JK
authors.lastname: Hong
authors.forename: J S
authors.initials: JS
authors.lastname: Yoo
authors.forename: Y H
authors.initials: YH
authors.lastname: Kho
mesh_terms: D003517:Cyclopentanes / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008543:Melanins / Q000037:antagonists & inhibitors / Q000096:biosynthesis* / Q000737:chemistry; D008968:Molecular Conformation; D009570:Nitriles / Q000737:chemistry*; D013237:Stereoisomerism; D014242:Trichoderma / Q000378:metabolism*
chemical_list: D003517:Cyclopentanes; C107805:MR 566A; C107806:MR 566B; D008543:Melanins; D009570:Nitriles