L-Selectin--a signalling receptor for lipopolysaccharide.
The activation of leukocytes by bacterial cell-wall lipopolysaccharide contributes to the pathogenesis of septic shock. We propose that in neutrophils, and possibly other leukocytes, L-selectin can act as a low-affinity lipopolysaccharide receptor. Inhibitors of L-selectin may therefore be of therapeutic value in treating this life-threatening condition.
Malhotra
R
R
Glycobiology Research Unit, Cellular Science Division, Glaxo-Wellcome Medicines Research Centre, Gunnel's Wood Road, Stevenage, Herts, SG1 2NY, UK. rm 18326@ggr.co.uk
Bird
M I
MI
D000818:Animals; D006801:Humans; D019041:L-Selectin / Q000502:physiology*; D018950:Lipopolysaccharide Receptors / Q000502:physiology; D008070:Lipopolysaccharides / Q000378:metabolism / Q000633:toxicity*; D008954:Models, Biological; D012772:Shock, Septic / Q000209:etiology; D015398:Signal Transduction / Q000502:physiology
D018950:Lipopolysaccharide Receptors; D008070:Lipopolysaccharides; D019041:L-Selectin