Ultrastructural study of endogenous lipid pneumonia and pulmonary alveolar proteinosis coexistent with lung cancer.
The aim of the study was the ultrastructural analysis of endogenous lipid pneumonia (ELP)-type changes localized in the vicinity of primary neoplasms of the lungs. The analysis was carried out on the material obtained from 30 patients with non-small cell lung carcinoma (NSCLC). Routine histopathological examination was performed in light microscope, focusing mainly on the presence or lack of ELP-type changes. Ultrastructural examinations in transmission electron microscope used 12 cases classified among early (4 cases) or advanced (8 cases) ELP forms. Results of the study reveal a likely coexistence of ELP- and PAP (pulmonary alveolar proteinosis)-type changes in the vicinity of NSCLC and suggest a correlation between the processes leading to the development of ELP or/and PAP. Ethiopathogenesis of the changes observed and the role of granulocytes, macrophages and type II alveolar epithelial cells are discussed.
Sulkowska
M
M
Department of Pathological Anatomy, Medical Academy, Białystok, Poland.
Sulkowski
S
S
Chyczewski
L
L
D002289:Carcinoma, Non-Small-Cell Lung / Q000473:pathology / Q000648:ultrastructure; D004848:Epithelium / Q000473:pathology / Q000648:ultrastructure; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology / Q000648:ultrastructure*; D011017:Pneumonia, Lipid / Q000473:pathology*; D011649:Pulmonary Alveolar Proteinosis / Q000473:pathology*; D011650:Pulmonary Alveoli / Q000473:pathology / Q000648:ultrastructure