Is my antihistamine safe?
The Food and Drug Administration (FDA) has announced its intention to withdraw the approval of terfenadine (Seldane), terfenadine with pseudoephedrine (Seldane D), and generic versions of terfenadine. Before granting approval for the marketing of fexofenadine (Allegra), terfenadine's active metabolite, the FDA determined terfenadine's benefits outweight its risks, despite its, known potential for serious cardiac effects.
Ashworth
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Mercer University's Southern School of Pharmacy, Atlanta, GA 30341-4155, USA.
D016907:Adverse Drug Reaction Reporting Systems; D006633:Histamine Antagonists / Q000009:adverse effects*; D006634:Histamine H1 Antagonists / Q000009:adverse effects*; D006801:Humans; D018579:Patient Selection; D016593:Terfenadine / Q000009:adverse effects* / Q000031:analogs & derivatives*; D014481:United States; D014486:United States Food and Drug Administration
D006633:Histamine Antagonists; D006634:Histamine H1 Antagonists; D016593:Terfenadine; C093230:fexofenadine