[Levels of Cu, Zn, Se and their relation to levels of ceruloplasmin and the activity of antioxidative enzymes].
BACKGROUND
Essential trace elements copper, zinc and selenium are important parts of antioxidant enzymes as superoxide dismutase, glutathione peroxidase as well as of transport protein with antioxidant properties-ceruloplasmin. Mentioned trace elements may affect antioxidant defence system.


OBJECTIVE
The aim of our study was to estimate serum levels of copper, zinc, and selenium in a group of healthy subjects and to correlate them with erythrocyte activity of Cu,Zn-SOD, GSH-Px and serum levels of ceruloplasmin.


METHODS
We examined a group of 128 healthy volunteers (57 men and 71 women) aged 20 to 74 years. The analyses of trace elements we performed by atomic absorption spectrophotometry, Cu,Zn-SOD were detected by Randox test, GSH-Px by kinetic method and ceruloplasmin was measured immunoelectrophoretically.


RESULTS
We have not found any correlations between investigated trace elements, age and sex. Average serum levels were as follows: copper (17.26 +/- 2.71 mumol/L), zinc (15.30 +/- 1.92 mumol/L), and selenium (0.79 +/- 0.19 mumol/L). There was a weak linear correlation between serum levels of copper and ceruloplasmin.


CONCLUSIONS
There was no relationship between serum copper and zinc levels and Cu,Zn-SOD activity, and serum concentration of selenium and GSH-Px activity in the group of healthy subjects. A moderate linear correlation was estimated between serum values of copper and ceruloplasmin. (Tab. 2, Fig. 4, Ref. 29.)
Magálová
T
T
Výskumný ústav výzivy v Bratislave, Slovakia.
Beno
I
I
Brtková
A
A
Mekinová
D
D
Volkovová
K
K
Staruchová
M
M
Tatara
M
M
D000328:Adult; D000368:Aged; D002570:Ceruloplasmin / Q000032:analysis*; D003300:Copper / Q000097:blood; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012643:Selenium / Q000097:blood; D013482:Superoxide Dismutase / Q000097:blood*; D014131:Trace Elements / Q000097:blood*; D015032:Zinc / Q000097:blood
D014131:Trace Elements; D003300:Copper; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D002570:Ceruloplasmin; D012643:Selenium; D015032:Zinc