title: Bioorganometallic chemistry--synthesis and antitumor activity of cobalt carbonyl complexes.
abstract: The interaction of organometallic compounds with biological systems, generally called bioorganometallic chemistry, is receiving increasing interest. We present the first part of our studies concerning the biological activity of organometallic compounds. Several alkyne-cobalt carbonyl complexes inhibited the growth of human melanoma and lung carcinoma cell lines. They are more active than uncomplexed dicobalt octacarbonyl, cobalt chloride, or the free ligand. A significant difference in potency towards the lung carcinoma cell line was observed among the cobalt complexes, indicating that the complexed ligand may influence cytotoxic activity. These results suggest that further exploratory work with such cobalt-alkyne complexes is warranted.
authors.affiliation: Institut für Pharmazeutische Chemie, Westfälische Wilhelms-Universität Münster, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Jung
authors.forename: D E
authors.initials: DE
authors.lastname: Kerr
authors.forename: P D
authors.initials: PD
authors.lastname: Senter
mesh_terms: D000230:Adenocarcinoma; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D002470:Cell Survival / Q000187:drug effects; D003035:Cobalt / Q000633:toxicity; D006801:Humans; D008175:Lung Neoplasms; D008545:Melanoma; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D009942:Organometallic Compounds; D003035:Cobalt