[High fever during the treatment of acute promyelocytic leukemia with all-trans retinoic acid].
A 56-year-old woman was admitted for evaluation of petechiae and acute promyelocytic leukemia was diagnosed. Administration of all-trans retinoic acid (ATRA) at 60 mg per day was begun. On the same day, high fever was recognized. There was no evidence of infection nor other organ dysfunction. Administration of steroid caused a resolution of the fever. The same phenomenon was observed three times subsequently. High fever was the adverse reaction in this patient during the treatment of ATRA, and steroid was dramatically effective.
Shirono
K
K
Division of Clinical Hematology and Immunology, Kumamoto City Hospital.
Igarashi
N
N
Tsuda
H
H
D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000009:adverse effects*; D005260:Female; D005334:Fever / Q000139:chemically induced* / Q000188:drug therapy; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000188:drug therapy*; D008775:Methylprednisolone / Q000627:therapeutic use; D008875:Middle Aged; D014212:Tretinoin / Q000009:adverse effects*
D000893:Anti-Inflammatory Agents; D000970:Antineoplastic Agents; D014212:Tretinoin; D008775:Methylprednisolone