Role of dendritic and follicular dendritic cells in HIV infection and pathogenesis.
Dendritic cells (DCs) and follicular dendritic cells (FDCs) play important roles in HIV-mediated pathogenesis. Recent studies have defined new DC subsets and shown that DCs in lymphoid mucosa can both harbor virus and stimulate its spread into CD4(+) T cells. FDCs harbor unspliced HIV mRNA and immune complexed virus, but not actively infectious virus, yet these cells are a key regulated reservoir of virions.
Grouard
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Regional Primate Research Center, Department of Microbiology, University of Washington Medical Center, Seattle, WA 98195, USA.
Clark
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D017951:Antigen Presentation; D003713:Dendritic Cells / Q000276:immunology* / Q000821:virology; D006678:HIV / Q000502:physiology*; D015488:HIV Antigens / Q000276:immunology; D015658:HIV Infections / Q000209:etiology / Q000276:immunology*; D006801:Humans; D008198:Lymph Nodes / Q000276:immunology / Q000648:ultrastructure; D009092:Mucous Membrane / Q000276:immunology / Q000473:pathology; D012333:RNA, Messenger / Q000378:metabolism; D012367:RNA, Viral / Q000378:metabolism; D011991:Receptors, Virus / Q000502:physiology; D014771:Virion / Q000502:physiology; D014779:Virus Replication
D015488:HIV Antigens; D012333:RNA, Messenger; D012367:RNA, Viral; D011991:Receptors, Virus