title: Complement-modulating properties of a kaempferol 7-O-rhamnosylsophoroside from the leaves of Morinda morindoides.
abstract: A kaempferol 7-O-rhamnosylsophoroside isolated from the leaves of Morinda morindoides showed dose-dependent complement-modulating properties towards both the classical (inhibiting effect) and alternative (activating effect) pathways of the complement system. Its structure was elucidated by chemical and spectroscopic methods as kaempferol 7-O-[alpha-L-rhamnopyranosyl-(1-->6)]-[beta-D-glucopyranosyl-(1-->2)]-be ta-D-glucopyranoside, a new natural product which was named morindaoside.
authors.affiliation: Department of Pharmaceutical Sciences, University of Antwerp (U.I.A.), Belgium.
authors.forename: K
authors.initials: K
authors.lastname: Cimanga
authors.forename: T
authors.initials: T
authors.lastname: de Bruyne
authors.forename: B
authors.initials: B
authors.lastname: Van Poel
authors.forename: Y
authors.initials: Y
authors.lastname: Ma
authors.forename: M
authors.initials: M
authors.lastname: Claeys
authors.forename: L
authors.initials: L
authors.lastname: Pieters
authors.forename: K
authors.initials: K
authors.lastname: Kambu
authors.forename: L
authors.initials: L
authors.lastname: Tona
authors.forename: P
authors.initials: P
authors.lastname: Bakana
authors.forename: D
authors.initials: D
authors.lastname: Vanden Berghe
authors.forename: A J
authors.initials: AJ
authors.lastname: Vlietinck
mesh_terms: D002240:Carbohydrate Sequence; D003167:Complement Activation / Q000187:drug effects*; D005419:Flavonoids; D006027:Glycosides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D044949:Kaempferols; D008519:Medicine, Traditional; D008969:Molecular Sequence Data; D015394:Molecular Structure; D018515:Plant Leaves; D010946:Plants, Medicinal; D011794:Quercetin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D005419:Flavonoids; D006027:Glycosides; D044949:Kaempferols; C107157:morindaoside; C006552:kaempferol; D011794:Quercetin