Endomysium: autoantigen in coeliac disease.
In coeliac disease, dietary exposure to gluten is associated with an autoimmune response to gastrointestinal antigens, including endomysium. Measurement of autoantibodies to endomysium is a highly specific and sensitive method of diagnosing coeliac disease. Analysis of the interaction between gluten and endomysium should provide a critical insight into the pathogenesis of this condition.
Feighery
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Department of Immunology, Trinity College, Dublin, Ireland.
Whelan
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A
Weir
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DG
D001323:Autoantibodies / Q000009:adverse effects / Q000276:immunology; D001324:Autoantigens / Q000276:immunology*; D002135:Calcium-Binding Proteins / Q000276:immunology; D037282:Calreticulin; D002446:Celiac Disease / Q000175:diagnosis / Q000276:immunology*; D005260:Female; D005983:Glutens / Q000276:immunology*; D006801:Humans; D008297:Male; D009130:Muscle, Smooth / Q000276:immunology*; D012261:Ribonucleoproteins / Q000276:immunology; D012737:Sex Factors
D001323:Autoantibodies; D001324:Autoantigens; D002135:Calcium-Binding Proteins; D037282:Calreticulin; D012261:Ribonucleoproteins; D005983:Glutens