Mechanisms and dynamics of antioxidant action of ubiquinol.
The mechanisms and dynamics of antioxidant action of ubiquinol have been studied. Ubiquinol scavenges peroxyl radical faster than alpha-tocopherol. However, it is autooxidized rapidly to give hydroperoxyl radical and/or superoxide and hence its antioxidant potency is smaller than that of alpha-tocopherol. The side chain of ubiquinol reduces the mobility between the membranes. It was concluded that ubiquinol acts as a potent antioxidant in combination with alpha-tocopherol.
Niki
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Research Center for Advanced Science and Technology, University of Tokyo, Japan.
D000818:Animals; D000975:Antioxidants / Q000493:pharmacokinetics / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000494:pharmacology; D004357:Drug Synergism; D006801:Humans; D008041:Linoleic Acids / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects*; D010084:Oxidation-Reduction; D010545:Peroxides / Q000378:metabolism; D010655:Phenylenediamines / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000494:pharmacology; D014810:Vitamin E / Q000493:pharmacokinetics / Q000494:pharmacology
D000975:Antioxidants; D008041:Linoleic Acids; D010545:Peroxides; D010655:Phenylenediamines; D017382:Reactive Oxygen Species; D014451:Ubiquinone; D014810:Vitamin E; C005575:methyl linoleate; C049375:perhydroxyl radical; C026663:ubiquinol-10; C004845:N,N'-diphenyl-4-phenylenediamine; C003741:ubiquinol; D001205:Ascorbic Acid