[Chronochemotherapy for cancer].
The chronomodulation of anticancer drugs arouses our interest as a method for cancer chemotherapy. The author reviewed recent clinical studies regarding circadian rhythms in 1) target tissues: healthy and cancer tissues; 2) chronopharmacology of anticancer drugs; and 3) chronotoxicity of anticancer drugs. A brief review is made of the main results of clinical phase II trials.
Akazawa
S
S
Dept. of Gastroenterology, Saitama Cancer Center, Japan.
D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000009:adverse effects / Q000493:pharmacokinetics; D002940:Circadian Rhythm; D017322:Clinical Trials, Phase II as Topic; D003967:Diarrhea / Q000139:chemically induced; D004334:Drug Administration Schedule; D006801:Humans; D009325:Nausea / Q000139:chemically induced; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D013280:Stomatitis / Q000139:chemically induced
D000970:Antineoplastic Agents