Impact of metoprolol on heart rate, blood pressure, and contractility in normal subjects during dobutamine stress echocardiography.
Dobutamine stress echocardiograms were performed in 6 volunteers under basal conditions and after 72 hours of metoprolol, 50 mg twice daily. Although heart rate responses were blunted, contractility increased to levels seen before beta blockade.
Marcovitz
P A
PA
Division of Cardiology, University of Michigan, Ann Arbor, USA.
Armstrong
W F
WF
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000328:Adult; D001794:Blood Pressure / Q000187:drug effects*; D002316:Cardiotonic Agents; D004280:Dobutamine; D004452:Echocardiography; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D008790:Metoprolol / Q000494:pharmacology*; D009200:Myocardial Contraction / Q000187:drug effects*
D000319:Adrenergic beta-Antagonists; D002316:Cardiotonic Agents; D004280:Dobutamine; D008790:Metoprolol