Activation of CD8 T cells with specificity for mycobacterial heat shock protein 60 in Mycobacterium bovis bacillus Calmette-Guérin-vaccinated mice.
Heat shock protein 60 (hsp60)-specific CD8 T cells lysed Mycobacterium bovis BCG-infected macrophages in vitro and adoptively transferred protection against mycobacterial infection. Moreover, CD8 T cells with this hsp60 specificity were activated in vivo by BCG vaccination. Our studies suggest there is participation of hsp60-specific CD8 T cells in BCG-induced immunity.
Zügel
U
U
Department of Immunology, University of Ulm, Germany.
Kaufmann
S H
SH
D019264:Adoptive Transfer; D000818:Animals; D001500:BCG Vaccine / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D018834:Chaperonin 60 / Q000276:immunology*; D003602:Cytotoxicity, Immunologic; D008213:Lymphocyte Activation; D008264:Macrophages / Q000276:immunology / Q000382:microbiology; D051379:Mice; D009163:Mycobacterium bovis / Q000276:immunology*; D013154:Spleen / Q000276:immunology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*
D001500:BCG Vaccine; D018834:Chaperonin 60