title: Effect of intraoperative fluid on blood glucose level in neurosurgery.
abstract: There is a considerable controversy regarding glucose administration during intracranial surgery. However, recent animal and human studies suggest that hyperglycemia exacerbates ischemic brain damage and intraoperative hypoglycemia may not be a concern if the surgical procedure is less than 4 hours. We, therefore, studied the blood glucose in neurosurgery with craniotomy in 90 Thai patients, divided into 3 groups. 30 patients in each group received balanced salt solution (0.9% NSS), 5 per cent glucose rate 60-80 ml/h and 5 per cent glucose rate more than 120 ml/h. Blood for the determination of glucose concentration was obtained after induction and every 2 hours later until the end of the surgery. There was one male patient in group I who received balanced salt solution (0.9% NSS) had blood glucose concentration lowered to 57 mg% at 4 hours after induction. The patients in group II who received 5 per cent glucose solution at maintenance rate did not have hyperglycemia (161.20 +/- 38.30 mg%). In group III; patients given 5 per cent glucose infusion at the rate of more than 120 ml/h had hyperglycemia (236.75 +/- 63.57 mg%) at 6 hours. In conclusion, we suggest that in Thai patients undergoing neurosurgical procedures; blood glucose levels should be checked intraoperatively if glucose is withheld from the intraoperative fluid regimen. Otherwise 80 ml/h of 5 per cent dextrose intravenous infusion should be given to the patients to prevent hypoglycemia.
authors.affiliation: Department of Anesthesiology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
authors.forename: W
authors.initials: W
authors.lastname: Ittichaikulthol
authors.forename: V
authors.initials: V
authors.lastname: Lekprasert
authors.forename: S
authors.initials: S
authors.lastname: Pausawasdi
authors.forename: P
authors.initials: P
authors.lastname: Suchartwatnachai
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D003399:Craniotomy; D005260:Female; D005947:Glucose / Q000008:administration & dosage*; D006801:Humans; D007003:Hypoglycemia / Q000517:prevention & control*; D007262:Infusions, Intravenous; D007430:Intraoperative Care; D008297:Male; D013785:Thailand
chemical_list: D001786:Blood Glucose; D005947:Glucose