Spontaneous remission of congenital leukemia.
Most patients with congenital leukemia do not survive past infancy despite aggressive chemotherapy. We describe three patients with congenital leukemia who have undergone prolonged periods of spontaneous remission. Our experience suggests that some patients with congenital leukemia may benefit from initial conservative management without chemotherapy. We summarize the clinical presentations of these patients and review the literature.
Dinulos
J G
JG
Department of Pediatrics, Children's Hospital and Medical Center, Seattle, WA 98105-0371, USA.
Hawkins
D S
DS
Clark
B S
BS
Francis
J S
JS
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001706:Biopsy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007231:Infant, Newborn; D007948:Leukemia, Monocytic, Acute / Q000151:congenital* / Q000188:drug therapy / Q000473:pathology; D007951:Leukemia, Myeloid / Q000151:congenital* / Q000473:pathology; D015479:Leukemia, Myelomonocytic, Acute / Q000151:congenital* / Q000188:drug therapy / Q000473:pathology; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy / Q000473:pathology; D009365:Neoplasm Regression, Spontaneous; D012074:Remission Induction; D012878:Skin Neoplasms / Q000151:congenital* / Q000473:pathology