How to starve a tumor.
The formation of new blood vessels, termed angiogenesis, is a central process in the evolution of a tumor and its subsequent metastasis. Angiogenesis is potently inhibited by the fumagillins, a family of epoxide-containing natural products. The recent identification of a protein target for these compounds may help decipher the mechanisms underlying endothelial cell growth. The fact that binding is irreversible may inspire the design of electrophilic inhibitors of other, poorly understood cellular processes.
Taunton
J
J
Department of Cellular and Molecular Pharmacology, School of Medicine, University of California, San Francisco 94143-0450, USA. taunton@cgl.ucsf.edu
D000626:Aminopeptidases / Q000037:antagonists & inhibitors; D003510:Cyclohexanes; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000627:therapeutic use; D004852:Epoxy Compounds / Q000737:chemistry; D005231:Fatty Acids, Unsaturated / Q000737:chemistry / Q000627:therapeutic use*; D063208:Methionyl Aminopeptidases; D009369:Neoplasms / Q000098:blood supply / Q000188:drug therapy*; D009389:Neovascularization, Pathologic / Q000188:drug therapy*; D012717:Sesquiterpenes
D003510:Cyclohexanes; D004791:Enzyme Inhibitors; D004852:Epoxy Compounds; D005231:Fatty Acids, Unsaturated; D012717:Sesquiterpenes; C026211:fumagillin; D000626:Aminopeptidases; D063208:Methionyl Aminopeptidases