[Synthesis of triterpene 2-deoxy-alpha-D-hexopyranosides on the basis of glycals and their effect on reparative processes].
Triterpene 2-deoxy-alpha-D-hexopyranosides were synthesized by the glycosylation of oleanane triterpene alcohols with D-glucal and D-galactal acetates in the presence of di(sym-collidine)iodonium perchlorate with subsequent deiodination and deacetylation of the resulting 2-deoxy-2-iodo-alpha-D-glycosides. 2-Deoxy-alpha-D-arabino- and -lyxo-hexopyranosides of methyl glycyrrhetinate demonstrated pronounced antiulcer activity and stimulated reparative skin regeneration in rats more effectively than glycyrrhizic acid and methyluracil.
Baltina
L A
LA
Flekhter
O B
OB
Vasil'eva
E V
EV
Davydova
V A
VA
Ismagilova
A F
AF
Zarudi'i
F S
FS
Tolstikov
G A
GA
D000818:Animals; D000897:Anti-Ulcer Agents / Q000138:chemical synthesis*; D003879:Dermatologic Agents / Q000138:chemical synthesis*; D006027:Glycosides / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D012867:Skin / Q000293:injuries; D013329:Structure-Activity Relationship; D014945:Wound Healing / Q000187:drug effects
D000897:Anti-Ulcer Agents; D003879:Dermatologic Agents; D006027:Glycosides