Physico-chemical properties and stability of the new hypoxia-selective agent 7-chloro-3-[[N,N-dimethylamino)propyl]amino]-2-quinoxalinecarbonitrile 1,4-di-N-oxide hydrochloride.
7-Chloro-3-[[N,N-dimethylamino)propyl]amino]-2-quinoxalinecarbonitril e 1,4-di-N-oxide hydrochloride (Q-85 HCl), a new hypoxia-selective agent, was studied to clarify its physico-chemical properties. Melting point, spectra (UV, IR, NMR, MS), thermal behaviour, solubility, pKa, partition coefficient and chromatographic characteristics (TLC, HPLC) have been determined. The stability of Q-85 HCl was studied under various conditions by HPLC. Q-85 HCl in solid state was very stable to heat and fairly stable to light. Some degradation products of Q-85 HCl were identified in basic solution.
Zamalloa
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Department of Medicinal Chemistry, University of Navarra, Pamplona, Spain.
Aldana
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Bachiller
C M
CM
Monge
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A
D002152:Calorimetry, Differential Scanning; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D004355:Drug Stability; D009682:Magnetic Resonance Spectroscopy; D011810:Quinoxalines / Q000737:chemistry*; D012995:Solubility; D012996:Solutions; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013818:Thermogravimetry
C108265:7-chloro-3-(((N,N-dimethylamino)propyl)amino)-2-quinoxalinecarbonitrile-1,4-di-N-oxide; D011810:Quinoxalines; D012996:Solutions