Association between schizophrenia and a microsatellite polymorphism at the dopamine D5 receptor gene.
An association study of 97 patients with DSM-III-R schizophrenia and 97 matched controls was performed using a polymorphic microsatellite repeat at the dopamine D5 receptor gene. We observed a significant difference between the allele frequencies of patients and controls (chi 2 = 23.4, df = 12, p = 0.019). This reflects an excess of allele 4 (140 bp) in the patients when compared with the control sample (chi 2 = 7.087, p < 0.01; odds ratio = 2.98, 95% CI 1.29-6.86). However, this association remains tentative until confirmation in other samples.
Williams
N M
NM
Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, UK.
Cardno
A G
AG
Murphy
K C
KC
Jones
L A
LA
Asherson
P
P
McGuffin
P
P
Owen
M J
MJ
D000483:Alleles; D004247:DNA / Q000097:blood; D005787:Gene Frequency; D006801:Humans; D018895:Microsatellite Repeats; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D017447:Receptors, Dopamine D1 / Q000235:genetics*; D050641:Receptors, Dopamine D5; D012016:Reference Values; D012559:Schizophrenia / Q000235:genetics*
C493605:DRD5 protein, human; D017447:Receptors, Dopamine D1; D050641:Receptors, Dopamine D5; D004247:DNA