Cetirizine treatment of allergic cough in children with pollen allergy.
Cetirizine, an antihistamine widely used in the treatment of allergic rhinoconjunctivitis, also has antiallergic activity. The present study aimed to evaluate cetirizine as a treatment for children with allergic cough due to pollen allergy. This was a parallel-group, double-blind, placebo-controlled, randomized study. Twenty children with pollinosis were enrolled: they were subdivided into two groups receiving a 1-month treatment during the pollen season. The following variables were monitored: 1) clinical symptoms and respiratory data (spirometry and PEF) evaluated at baseline and at the end of the study by allergists and by a daily diary card, and 2) pollen count. This study shows that cetirizine treatment reduces cough intensity (P < 0.05) and frequency (P < 0.01). In conclusion, cetirizine does clinically improve cough due to pollen allergy.
Ciprandi
G
G
Department of Internal Medicine, Genoa University, Italy.
Tosca
M
M
Ricca
V
V
Passalacqua
G
G
Fregonese
L
L
Fasce
L
L
Canonica
G W
GW
D000293:Adolescent; D018926:Anti-Allergic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D017332:Cetirizine / Q000008:administration & dosage / Q000627:therapeutic use*; D002648:Child; D003371:Cough / Q000175:diagnosis / Q000276:immunology; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D010366:Peak Expiratory Flow Rate; D011058:Pollen / Q000276:immunology; D012130:Respiratory Hypersensitivity / Q000188:drug therapy*; D013147:Spirometry
D018926:Anti-Allergic Agents; D017332:Cetirizine