title: Fine mapping of a genetic locus for Peutz-Jeghers syndrome on chromosome 19p.
abstract: Peutz-Jeghers syndrome (PJS) was recently mapped in a single report to the telomeric region of chromosome 19p (A. Hemminki et al., Nat. Genet., 15: 87-90, 1997). Our studies confirm this location and provide further localization of the PJS locus. In the five families examined, there were no recombinants with the marker D19S886. The multipoint log odds score at D19S886 is 7.52, and we found no evidence for genetic heterogeneity. We also found that all carriers expressed the PJS phenotype and no noncarriers displayed PJS sequellae, indicating complete penetrance with no sporadic cases.
authors.affiliation: Department of Epidemiology, University of Texas M.D. Anderson Cancer Center, Houston 77030, USA.
authors.forename: C I
authors.initials: CI
authors.lastname: Amos
authors.forename: D
authors.initials: D
authors.lastname: Bali
authors.forename: T J
authors.initials: TJ
authors.lastname: Thiel
authors.forename: J P
authors.initials: JP
authors.lastname: Anderson
authors.forename: I
authors.initials: I
authors.lastname: Gourley
authors.forename: M L
authors.initials: ML
authors.lastname: Frazier
authors.forename: P M
authors.initials: PM
authors.lastname: Lynch
authors.forename: M A
authors.initials: MA
authors.lastname: Luchtefeld
authors.forename: A
authors.initials: A
authors.lastname: Young
authors.forename: T J
authors.initials: TJ
authors.lastname: McGarrity
authors.forename: M F
authors.initials: MF
authors.lastname: Seldin
mesh_terms: D002874:Chromosome Mapping / Q000379:methods*; D002888:Chromosomes, Human, Pair 19 / Q000235:genetics*; D005260:Female; D005819:Genetic Markers; D006579:Heterozygote; D006801:Humans; D008126:Lod Score; D008297:Male; D010375:Pedigree; D010580:Peutz-Jeghers Syndrome / Q000235:genetics*; D010641:Phenotype
chemical_list: D005819:Genetic Markers