Facile and general method for preparation of (E)-4-hydroxy-2-alkenals.
A facile one-pot synthesis of (E)-4-hydroxy-2-alkenals such as (E)-4-hydroxy-2-nonenal, (E)-4-hydroxy-2-heptenal, and (E)-4-hydroxy-2-hexenal was achieved from the corresponding (2E,4E)-2,4-alkadienals by reduction-oxygenation with molecular oxygen and triethylsilane in the presence of cobalt(II) porphyrin as a catalyst followed by treatment with trimethylphosphite.
Sugamoto
K
K
Department of Materials Science, Faculty of Engineering, Miyazaki University, Japan. t0a304u@cc.miyazaki-u.ac.jp
Matsushita
Y
Y
Matsui
T
T
D000447:Aldehydes / Q000138:chemical synthesis*; D003035:Cobalt / Q000737:chemistry; D005233:Fatty Alcohols / Q000138:chemical synthesis*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008665:Metalloporphyrins / Q000737:chemistry; D009942:Organometallic Compounds / Q000737:chemistry; D010084:Oxidation-Reduction
C108331:(5,10,15,20-tetrakis(2,6-dichlorophenyl)porphinato)cobalt(II); D000447:Aldehydes; D005233:Fatty Alcohols; D008665:Metalloporphyrins; D009942:Organometallic Compounds; C045934:4-hydroxy-2-hexenal; D003035:Cobalt; C027576:4-hydroxy-2-nonenal