Use of adriamycin-impregnated methylmethacrylate in the treatment of tumor metastases in the long bones.
Internal fixation or endoprosthetic replacement of a long bone metastatic lesion was performed using adriamycin-containing bone cement (methylmethacrylate) after resection or curettage of the lesion in 25 patients (27 limbs). Survival rate, limb function, and local recurrence rate were retrospectively evaluated in this patient cohort. Survival rate was 53% at 12 months and 30% at 24 months, which was better than in previous reports. One patient showed local recurrence radiographically. Postoperatively, none of the patients developed infection, delayed wound healing, myelo-suppression attributed to adriamycin, and 74% of the patients were able to walk outdoors.
Katagiri
H
H
Department of Orthopaedic Surgery, Nagoya University School of Medicine, Japan.
Sato
K
K
Takahashi
M
M
Sugiura
H
H
Yamamura
S
S
Iwata
H
H
D000293:Adolescent; D000328:Adult; D000368:Aged; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage*; D001843:Bone Cements; D001859:Bone Neoplasms / Q000401:mortality / Q000556:secondary* / Q000601:surgery*; D004317:Doxorubicin / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008297:Male; D020366:Methylmethacrylate; D008768:Methylmethacrylates; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D011183:Postoperative Complications; D015996:Survival Rate
D000903:Antibiotics, Antineoplastic; D001843:Bone Cements; D008768:Methylmethacrylates; D020366:Methylmethacrylate; D004317:Doxorubicin