title: Intensive nutritional counselling in bulimia nervosa: a role for supplementation with fluoxetine?
abstract: OBJECTIVE
  The aims of the paper are to determine whether nutritional counselling is associated with an improvement in bulimic symptomatology, whether this improvement is maintained during post-treatment follow-up, and whether the addition of fluoxetine 3 x 20 mg/day confers additional benefit.
  
  
  METHODS
  Psychological, pharmacological and combined psychopharmacological treatments of bulimia nervosa were reviewed briefly. Sixty-seven patients referred to specialist eating disorder services who fulfilled strict diagnostic criteria were treated with intensive nutritional counselling and randomly assigned to either fluoxetine 3 x 20 mg/day or placebo. After a 1-week 'wash-out', active treatment was given over 8 weeks, followed by post-treatment interviews at 12 and 20 weeks.
  
  
  RESULTS
  Both groups of patients improved significantly during treatment. In some respects, the fluoxetine group did slightly better as demonstrated by the items 'restraint', 'weight concern' and 'shape concern' (p < 0.05 vs p < 0.0001) on the Eating Disorder Examination (EDE). Fluoxetine patients decreased their energy intake and lost a modest amount of weight. They went on to regain weight during the follow-up period, returning to levels higher than they were initially. These patients also appeared more likely to have a recurrence of symptoms, as shown by the fall in percentage of binge-free patients and by changes in the EDE.
  
  
  CONCLUSIONS
  Nutritional counselling is an effective means of treating bulimia nervosa, with improvement maintained up to 3 months follow-up. The addition of fluoxetine may confer some benefit during active treatment, but its discontinuation may contribute to a higher rate of recurrence of symptoms post treatment. Of course, this study cannot be extrapolated to the efficacy of fluoxetine when used as the only form of treatment in patients for whom intensive nutritional counselling or other structured psychological programs are not available.
authors.affiliation: Department of Psychological Medicine, University of Sydney, New South Wales, Australia.
authors.forename: P J
authors.initials: PJ
authors.lastname: Beumont
authors.forename: J D
authors.initials: JD
authors.lastname: Russell
authors.forename: S W
authors.initials: SW
authors.lastname: Touyz
authors.forename: C
authors.initials: C
authors.lastname: Buckley
authors.forename: K
authors.initials: K
authors.lastname: Lowinger
authors.forename: P
authors.initials: P
authors.lastname: Talbot
authors.forename: G F
authors.initials: GF
authors.lastname: Johnson
mesh_terms: D000293:Adolescent; D000328:Adult; D002032:Bulimia / Q000523:psychology / Q000534:rehabilitation*; D003131:Combined Modality Therapy; D003376:Counseling; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D005260:Female; D005473:Fluoxetine / Q000008:administration & dosage* / Q000009:adverse effects; D005500:Follow-Up Studies; D006801:Humans; D052756:Nutritional Sciences / Q000193:education*; D010352:Patient Dropouts / Q000523:psychology; D017367:Selective Serotonin Reuptake Inhibitors / Q000008:administration & dosage* / Q000009:adverse effects; D016896:Treatment Outcome
chemical_list: D005473:Fluoxetine; D017367:Selective Serotonin Reuptake Inhibitors