title: HIV-associated oral pleomorphic B-cell malignant lymphoma.
abstract: A 48-year-old HIV-seropositive homosexual patient presented with an ulcerative lesion in the left side of the soft palate, extensively involving local soft tissue structures. On histologic evaluation the lesions appeared to be a large-cell high-grade B-cell pleomorphic lymphoma with anaplastic and plasmacytoid features harboring Epstein-Barr virus genome in the tumor cells. Although known to be associated with HIV infection, this is a rare subtype of a malignant lymphoma arising in a patient positive for HIV. Its meaning is yet unknown in biologic and prognostic terms.
authors.affiliation: Department of Oral Medicine, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
authors.forename: T
authors.initials: T
authors.lastname: Vázquez-Piñeiro
authors.forename: L
authors.initials: L
authors.lastname: Viana de Frías
authors.forename: E
authors.initials: E
authors.lastname: Cristóbal
authors.forename: J
authors.initials: J
authors.lastname: Cosín
authors.forename: J
authors.initials: J
authors.lastname: Menárguez
mesh_terms: D017809:Fatal Outcome; D004854:Herpesvirus 4, Human / Q000235:genetics; D006801:Humans; D016483:Lymphoma, AIDS-Related / Q000473:pathology* / Q000821:virology*; D017728:Lymphoma, Large-Cell, Anaplastic / Q000473:pathology* / Q000821:virology*; D008297:Male; D008875:Middle Aged; D009959:Oropharyngeal Neoplasms / Q000473:pathology* / Q000821:virology*; D012367:RNA, Viral / Q000032:analysis; D014057:Tomography, X-Ray Computed
chemical_list: D012367:RNA, Viral