Association of hypercalcemia, PTHrP expression and disease progression in a woman with primary squamous cell carcinoma of the breast.
This paper describes humoral hypercalcemia of malignancy (HHM) associated with squamous cell carcinoma (SCC) of the breast and its association with assayed levels of parathyroid hormone related protein (PTHrP). A 57-year-old woman presented with locally advanced SCC of the breast. The diagnosis was supported by serum analysis and histological and immunohistochemical findings. She was initially treated with chemotherapy to reduce the tumor bulk but developed symptomatic hypercalcemia after on course. The hypercalcemia was effectively treated with intravenous amino hydroxy propildene diphosphonate. Subsequently the tumor progressed despite multimodality therapy and was associated with recurrent hypercalcemia. The patient died nine months after presentation.
Pillay
P
P
Department of Clinical Hematology and Medical Oncology, Box Hill Hospital, Vic, Australia.
Goldstein
D
D
Hayman
J A
JA
Leyden
M
M
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000150:complications / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology*; D002294:Carcinoma, Squamous Cell / Q000150:complications / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology*; D018450:Disease Progression; D006801:Humans; D006934:Hypercalcemia / Q000209:etiology*; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000096:biosynthesis*; D010281:Parathyroid Hormone / Q000096:biosynthesis*; D044162:Parathyroid Hormone-Related Protein; D014176:Protein Biosynthesis
D009363:Neoplasm Proteins; C470121:PTHLH protein, human; D010281:Parathyroid Hormone; D044162:Parathyroid Hormone-Related Protein