Oxygen tensions in rodent tumors after irradiation with neutrons.
We started investigations on intratumoral oxygen tension after irradiations with reactor fission neutrons using the Eppendorf-pO2 Histograph. Isotransplanted AT17-mammary carcinomas on C3H-mice and osteosarcomas OTS-64 on balb C-mice received 2 or 6 Gy neutrons single dose. Before and at certain points of time after treatment the pO2 values were evaluated. Some tumors with initially low median pO2 values showed a short-lasting increase between 2 and 24 h after irradiation. In those tumors with relatively high pretherapeutic pO2 values the pO2 decreased to the range of hypoxia. A third group of tumors showed no marked changes after irradiation. No tumor stopped growth during the observation period.
Weissfloch
L
L
Clinic and Policlinic for Radiotherapy and Radiation Oncology, Technische Universitaet Munich, Germany.
Auberger
T
T
Senekowitsch-Schmidtke
R
R
Wagner
F M
FM
Tempel
K
K
Molls
M
M
D000818:Animals; D005214:Fast Neutrons / Q000627:therapeutic use*; D005260:Female; D007700:Kinetics; D008325:Mammary Neoplasms, Experimental / Q000378:metabolism / Q000473:pathology / Q000532:radiotherapy; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D009374:Neoplasms, Experimental / Q000378:metabolism* / Q000473:pathology / Q000532:radiotherapy*; D012516:Osteosarcoma / Q000378:metabolism / Q000473:pathology / Q000532:radiotherapy; D010100:Oxygen / Q000378:metabolism*
D010100:Oxygen