Immunogenicity and reactogenicity of a booster dose of diphtheria, tetanus, acellular pertussis and inactivated poliomyelitis vaccines given concurrently with Haemophilus type b conjugate vaccine or as pentavalent vaccine.
BACKGROUND
The high reactogenicity of whole cell pertussis vaccines discourages their use in children. While acellular pertussis vaccines are less reactogenic, their use in diphtheria-tetanus-acellular pertussis (DTPa)-based combinations with Haemophilus influenzae type b conjugate vaccine (Hib) and poliomyelitis vaccines must be evaluated.


OBJECTIVE
To assess the immunogenicity and reactogenicity of a booster dose of diphtheria, tetanus, acellular pertussis and inactivated poliomyelitis vaccine (DTPa-IPV) given concurrently with Hib as a mixed vaccine or as separate injections, in comparison with a whole cell pertussis vaccine (DTPw-IPV-Hib).


METHODS
This open, randomized, controlled study involved 145 healthy children ages 15 to 24 months. Immunogenicity was evaluated for all vaccine antigens, and reactogenicity was assessed with diary cards.


RESULTS
Serum antibody responses to all vaccine antigens was at least as good as that observed with the pentavalent whole cell vaccine. DTPa-IPV was well-tolerated and less reactogenic than the DTPw-IPV vaccine. Administration of DTPa-IPV and Hib vaccine either separately or mixed did not alter the immunogenicity or reactogenicity profiles.


CONCLUSIONS
DTPa-IPV vaccine, either separately or mixed with Hib vaccine, was at least as immunogenic and less reactogenic than the DTPw-Hib vaccine. Mixing DTPa-IPV and Hib vaccines did not alter the safety profile when compared with separate injections of both vaccines. A mixed DTPa-IPV-Hib vaccine can be recommended for routine use as a booster dose in primed children.
Bégué
P
P
Hôpital d'enfants Armand-Trousseau, Maladies Infectieuses et Tropicales, Paris, France.
Stagnara
J
J
Vie-Le-Sage
F
F
Bernard
J C
JC
Xerri
B
B
Abitbol
V
V
D000907:Antibodies, Bacterial / Q000097:blood; D000914:Antibodies, Viral / Q000097:blood; D016667:Bacterial Capsules; D002675:Child, Preschool; D015721:Diphtheria-Tetanus-Pertussis Vaccine / Q000009:adverse effects / Q000276:immunology*; D005260:Female; D018073:Haemophilus Vaccines / Q000009:adverse effects / Q000276:immunology*; D006801:Humans; D007117:Immunization, Secondary; D007223:Infant; D008297:Male; D011054:Poliovirus Vaccine, Inactivated / Q000009:adverse effects / Q000276:immunology*; D011135:Polysaccharides, Bacterial / Q000009:adverse effects / Q000276:immunology*
D000907:Antibodies, Bacterial; D000914:Antibodies, Viral; D015721:Diphtheria-Tetanus-Pertussis Vaccine; D018073:Haemophilus Vaccines; C044237:Haemophilus influenzae type b polysaccharide vaccine; D011054:Poliovirus Vaccine, Inactivated; D011135:Polysaccharides, Bacterial