Interaction of cyclophosphamide and ketamine in vivo.
Cyclophosphamide 100 mg/kg i.p. increased the duration of ketamine-induced anesthesia in BALB/c mice by 39%. However, combined action of these two substances did not change the number of splenocytes, proliferation of T cells, or phagocytic activity of murine peritoneal macrophages against Candida albicans.
Rojavin
M A
MA
Richard J. Fox Center for Biomedical Physics, Temple University School of Medicine, Philadelphia, Pa 19140, USA. rojavin@astro.ocis.temple.edu
Tsygankov
A Y
AY
Ziskin
M C
MC
D000758:Anesthesia; D000778:Anesthetics, Dissociative / Q000494:pharmacology*; D000818:Animals; D003520:Cyclophosphamide / Q000494:pharmacology*; D004347:Drug Interactions; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D007649:Ketamine / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D013154:Spleen / Q000166:cytology / Q000187:drug effects; D013601:T-Lymphocytes / Q000187:drug effects / Q000378:metabolism; D013997:Time Factors
D000778:Anesthetics, Dissociative; D007166:Immunosuppressive Agents; D007649:Ketamine; D003520:Cyclophosphamide