Azithromycin in non-gonococcal urethritis.
The efficacy and safety of a single 1 g oral dose of azithromycin was evaluated in 100 male patients with non-gonococcal urethritis (NGU). Enrolled were men with > or = 5 polymorphonuclear leukocytes (PMNL)/high power field (HPF) (x 1000 magnification) in a Gram-stained smear of urethral discharge with or without symptoms and signs of NGU. Of the 66 evaluable patients, Chlamydia trachomatis was isolated from 18 cases (27.3%) and Ureaplasma urealyticum from 12 cases (18.2%). After treatment, signs and symptoms disappeared from 59 cases (89.4%). Forty-four cases (66.7%) showed reduced PMNL/HPF. C. trachomatis was eradicated in 18 cases (100%) and U. urealyticum in 12 cases (83.3%). One patient complained of mild dizziness, moderate nausea, and palpitations. Single 1 g oral dose of azithromycin appears to be effective and safe for treating chlamydial, non-chlamydial, and ureaplasmal NGU. In addition, its ease of use encourages patient compliance.
Charoenwatanachokchai
A
A
Department of Communicable Disease Control, Ministry of Public Health, Bangkok, Thailand.
Chitwarakorn
A
A
Palanuvej
T
T
Pakdeewong
S
S
Khumhaeng
M
M
Kreaurat
M
M
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D017963:Azithromycin / Q000008:administration & dosage*; D002690:Chlamydia Infections / Q000188:drug therapy; D002692:Chlamydia trachomatis / Q000302:isolation & purification; D006801:Humans; D008297:Male; D016869:Ureaplasma Infections / Q000188:drug therapy; D016990:Ureaplasma urealyticum / Q000302:isolation & purification; D014526:Urethritis / Q000188:drug therapy* / Q000382:microbiology*
D000900:Anti-Bacterial Agents; D017963:Azithromycin