Fluviols, bicyclic nitrogen-rich antibiotics produced by Pseudomonas fluorescens.
Fifteen fluorescent pseudomonads, isolated from the rhizosphere of agricultural plants, were similar in both their phenotypic properties and the chemical nature of produced pigments, to the previously described Pseudomonas fluorescens var. pseudoiodinum. DNA-DNA hybridisation data showed their genetic similarity (but not identity) to different biovars of P. fluorescens. A family of antibiotics-fluviols belonging to pyrazolo-[4,3-e]as-triazine derivatives was isolated from studied strains; isolation, properties, antimicrobial and antitumour activity of fluviols are described.
Smirnov
V V
VV
Zabolotny Institute of Microbiology and Virology of Ukrainian Academy of Sciences, Kiev, Ukraine.
Kiprianova
E A
EA
Garagulya
A D
AD
Esipov
S E
SE
Dovjenko
S A
SA
D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D000903:Antibiotics, Antineoplastic / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D001482:Base Composition; D002286:Carcinoma, Ehrlich Tumor; D004269:DNA, Bacterial / Q000737:chemistry; D005285:Fermentation; D005658:Fungi / Q000187:drug effects; D051379:Mice; D011551:Pseudomonas fluorescens / Q000737:chemistry* / Q000235:genetics; D011720:Pyrazoles / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D012689:Sequence Homology, Nucleic Acid; D014227:Triazines / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; D004269:DNA, Bacterial; D011720:Pyrazoles; D014227:Triazines