title: Roles of GABA, glutamate, acetylcholine and STN stimulation on thalamic VM in rats.
abstract: The effects of high frequency stimulation of the subthalamic nucleus (STN) and of iontophoretic application of different neurotransmitters on neuronal activities of the ventromedial thalamic nucleus (VM) were investigated in rats. GABA, when applied iontophoretically, inhibited VM neuronal activity while bicuculline, L-glutamic acid and acetylcholine enhanced the firing rates of the same VM neurons. High frequency stimulation of the STN increased VM neuronal activity in a frequency-dependent manner, which could be blocked by MK801. These results suggest that GABAergic, cholinergic and glutamatergic input information converge in the same VM neurons and that an increase in the delivery of glutamatergic neurotransmitter activities in the VM is involved in the process of high frequency stimulation of the STN.
authors.affiliation: INSERM U. 318, Neurobiologie préclinique, CHU, Grenoble, France.
authors.forename: D
authors.initials: D
authors.lastname: Gao
authors.forename: A
authors.initials: A
authors.lastname: Benazzouz
authors.forename: K
authors.initials: K
authors.lastname: Bressand
authors.forename: B
authors.initials: B
authors.lastname: Piallat
authors.forename: A L
authors.initials: AL
authors.lastname: Benabid
mesh_terms: D000109:Acetylcholine / Q000494:pharmacology*; D000818:Animals; D001640:Bicuculline / Q000494:pharmacology; D016291:Dizocilpine Maleate / Q000494:pharmacology; D004558:Electric Stimulation; D005071:Evoked Potentials / Q000187:drug effects; D018698:Glutamic Acid / Q000494:pharmacology*; D008297:Male; D008839:Microelectrodes; D009474:Neurons / Q000502:physiology*; D018377:Neurotransmitter Agents / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013787:Thalamic Nuclei / Q000187:drug effects / Q000502:physiology*; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology*
chemical_list: D018377:Neurotransmitter Agents; D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid; D016291:Dizocilpine Maleate; D000109:Acetylcholine; D001640:Bicuculline