Torsades de pointes with terfenadine ingestion.
Torsades de pointes (TDP) is a ventricular tachycardia that can deteriorate into ventricular fibrillation. TDP has been associated with terfenadine use in cases of liver disease, electrolyte abnormalities, concomitant administration of drugs that inhibit cytochrome P-450, or deliberate overdose. This report describes the first case of TDP in a healthy patient taking the recommended therapeutic dosage of terfenadine.
June
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Department of Emergency Medicine, Cook County Hospital, Chicago, IL 60612, USA.
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D004630:Emergencies; D006634:Histamine H1 Antagonists / Q000506:poisoning*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016593:Terfenadine / Q000506:poisoning*; D016171:Torsades de Pointes / Q000139:chemically induced*
D006634:Histamine H1 Antagonists; D016593:Terfenadine