Biochemistry of inflammatory processes and vascular injury. Role of neutrophils: a review.
Possible mechanisms of the participation of neutrophils in inflammation and vascular damage are reviewed. The role of chemotaxis, adhesion, and neutrophil-endothelium interaction are considered. Specific attention is paid to the action of neutrophils (PMNs) in inflammation sites which can be caused by the interaction between PMN-generated proteinases and oxygen metabolites.
Belova
L A
LA
Russian Cardiology Research Complex, Moscow, Russia.
D000818:Animals; D001808:Blood Vessels / Q000293:injuries* / Q000503:physiopathology; D002634:Chemotaxis, Leukocyte; D010450:Endopeptidases / Q000378:metabolism; D004730:Endothelium, Vascular / Q000503:physiopathology; D005609:Free Radicals / Q000378:metabolism; D006801:Humans; D006867:Hydrolases / Q000378:metabolism; D007249:Inflammation / Q000209:etiology / Q000378:metabolism* / Q000503:physiopathology; D009504:Neutrophils / Q000502:physiology*; D010100:Oxygen / Q000378:metabolism; D016897:Respiratory Burst
D005609:Free Radicals; D006867:Hydrolases; D010450:Endopeptidases; D010100:Oxygen