title: A surprisingly ameliorating effect of high doses of estradiol in primary osteomyelofibrosis: a case report.
abstract: OBJECTIVE
  To report a case of a postmenopausal woman with primary (idiopathic) osteomyelofibrosis who showed a considerable improvement under the effect of high doses of estradiol given for the control of severe intractable menopausal symptoms.
  
  
  METHODS
  This study was carried out by a case report.
  
  
  RESULTS
  Astonishingly, under the effect of high doses of estradiol, both clinical and laboratory indices of the disease were not only kept stable but also showed a noticeable improvement. Hemoglobin increased from a value of 8.4 gm/dl in 1989 to 10.7 gm/dl in 1996. Blood transfusion was no longer necessary, the patient had had no infections whatsoever and was only afraid of not being allowed to continue using these high estrogen doses, which seemed indispensable and central to her well-being.
  
  
  CONCLUSIONS
  High doses of estrogens could possibly be given the credit for ameliorating the natural sinister course of primary osteomyelofibrosis.
authors.affiliation: Department of Obstetrics and Gynecology, University of Freiburg, Germany. anasr@frk1.uk1.uni-freiburg.de
authors.forename: A
authors.initials: A
authors.lastname: Nasr
authors.forename: M
authors.initials: M
authors.lastname: Breckwoldt
mesh_terms: D002979:Climacteric / Q000187:drug effects*; D004304:Dosage Forms; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D004958:Estradiol / Q000008:administration & dosage* / Q000097:blood; D015914:Estrogen Replacement Therapy; D005260:Female; D006411:Hematopoiesis, Extramedullary / Q000187:drug effects; D006452:Hemoglobinometry; D006801:Humans; D008875:Middle Aged; D055728:Primary Myelofibrosis / Q000097:blood / Q000188:drug therapy*
chemical_list: D004304:Dosage Forms; D004958:Estradiol