title: The study of steady magnetic fields associated with primary and secondary ST shift in ischaemic rabbit hearts.
abstract: The study of injury potentials associated with DC currents that generate the primary or secondary ST shifts during cardiac ischaemia is possible only through the invasive technique of the DC electrogram. Clinical surface ECG recordings are AC coupled and cannot be used. This paper reports the use of non-invasive and unshielded magnetocardiographic measurements to evaluate the DC injury currents associated with ST shifts during coronary artery occlusions in the isolated rabbit heart. The effect on the magnetic ST shift is studied under different ischaemic conditions including regional ischaemia, global ischaemia, global ischaemia following long periods of regional ischaemia, regional ischaemia after repeated episodes of reversible global ischaemia, and bilateral regional ischaemia. Recording of DC magnetic fields allows the characterization of primary and secondary ST displacement for each induced ischaemic condition. Our measurements show that the ST shift starts earlier when inducing ischaemia in hearts previously subjected to ischaemic episodes than in hearts where the ischaemia was produced for the first time.
authors.affiliation: Department of Physics, Pontificia Universidade Católica, Rio de Janeiro, Brazil.
authors.forename: E C
authors.initials: EC
authors.lastname: Monteiro
authors.forename: S
authors.initials: S
authors.lastname: Della Penna
authors.forename: L
authors.initials: L
authors.lastname: Di Donato
authors.forename: S
authors.initials: S
authors.lastname: Di Luzio
authors.forename: A
authors.initials: A
authors.lastname: Pasquarelli
authors.forename: S N
authors.initials: SN
authors.lastname: Erné
authors.forename: G L
authors.initials: GL
authors.lastname: Romani
mesh_terms: D000818:Animals; D004562:Electrocardiography; D004574:Electromagnetic Fields; D017202:Myocardial Ischemia / Q000503:physiopathology*; D011817:Rabbits