Calcium regulation of neurotransmitter release: reliably unreliable?
Recent studies of central synaptic transmission reveal that neurotransmitter release is more unreliable than was previously thought. Nerve stimulation does not always elicit transmitter release, and when release events occur vesicle fusion with the presynaptic membrane is limited to at most a single quantum.
Goda
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Department of Biology, University of California, San Diego, La Jolla 92093-0366, USA. ygoda@jeeves.ucsd.edu
Südhof
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TC
D000818:Animals; D001921:Brain / Q000502:physiology*; D002118:Calcium / Q000502:physiology*; D015220:Calcium Channels / Q000502:physiology; D002462:Cell Membrane / Q000502:physiology; D004705:Endocytosis; D005089:Exocytosis; D019204:GTP-Binding Proteins / Q000502:physiology; D006706:Homeostasis; D008561:Membrane Fusion; D008959:Models, Neurological; D009474:Neurons / Q000502:physiology*; D018377:Neurotransmitter Agents / Q000502:physiology*; D011789:Quantum Theory; D013569:Synapses / Q000502:physiology*; D013570:Synaptic Membranes / Q000502:physiology
D015220:Calcium Channels; D018377:Neurotransmitter Agents; D019204:GTP-Binding Proteins; D002118:Calcium