title: Seroprevalence of human papillomavirus types 6 and 16 capsid antibodies in homosexual men.
abstract: Human papillomavirus (HPV) has been implicated in the pathogenesis of anal carcinoma, which is increased in homosexual men. Little is known about the serologic response to HPV in normal or immunosuppressed men; therefore, HIV-infected and -uninfected homosexual men were screened for HPV-6 and -16 capsid antibodies. HIV-infected men had increased HPV DNA detection but did not significantly differ in the prevalence of serum HPV antibodies. HPV-6 DNA detection and the presence of anal warts were significantly correlated with serum antibody overall and in the HIV-infected subgroup. HPV-16 DNA detection was not significantly correlated with serum antibody overall or in either subgroup; however, HIV-infected men with high-grade anal squamous intraepithelial lesions were significantly more likely to have HPV-16 antibodies. HIV-infected men are able to generate an antibody response to HPV, and a lack of serum HPV antibodies cannot explain the increased HPV-associated disease seen in HIV-infected men.
authors.affiliation: Fred Hutchinson Cancer Research Center and Department of Medicine, University of Washington, Seattle 98104, USA.
authors.forename: M E
authors.initials: ME
authors.lastname: Hagensee
authors.forename: N
authors.initials: N
authors.lastname: Kiviat
authors.forename: C W
authors.initials: CW
authors.lastname: Critchlow
authors.forename: S E
authors.initials: SE
authors.lastname: Hawes
authors.forename: J
authors.initials: J
authors.lastname: Kuypers
authors.forename: S
authors.initials: S
authors.lastname: Holte
authors.forename: D A
authors.initials: DA
authors.lastname: Galloway
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000453:epidemiology / Q000276:immunology / Q000821:virology*; D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000097:blood*; D002213:Capsid / Q000276:immunology*; D004279:DNA, Viral; D004797:Enzyme-Linked Immunosorbent Assay; D018451:Homosexuality, Male; D006801:Humans; D008297:Male; D008875:Middle Aged; D027383:Papillomaviridae / Q000235:genetics / Q000276:immunology*; D030361:Papillomavirus Infections / Q000150:complications / Q000453:epidemiology / Q000276:immunology / Q000821:virology; D015995:Prevalence; D014412:Tumor Virus Infections / Q000150:complications / Q000453:epidemiology* / Q000276:immunology* / Q000821:virology; D014860:Warts / Q000150:complications / Q000453:epidemiology
chemical_list: D000914:Antibodies, Viral; D004279:DNA, Viral