Bronchiolitis obliterans and IgA nephropathy. A new cause of pulmonary-renal syndrome.
IgA nephropathy is a common form of glomerulonephritis, classically manifested by asymptomatic hematuria. Although the exact pathophysiologic mechanism is still unknown, renal damage has been related to mesangial deposition of IgA-containing immune complexes. In recent years, some lung diseases have been associated with IgA nephropathy, including pulmonary hemorrhage and sarcoidosis. We report a patient with idiopathic bronchiolitis obliterans who developed a rapidly progressive glomerulonephritis due to IgA deposits. Extensive deposits of IgA were also found in the lungs, thus suggesting a pathogenetic role for IgA in tissue injury at both organ levels. To our knowledge this association has not been previously described in the literature.
Hernández
J I
JI
Department of Internal Medicine, Hospital Marqués de Valdecilla, University of Cantabria, Santander, Spain.
Gómez-Román
J
J
Rodrigo
E
E
Olmos
J M
JM
González-Vela
C
C
Ruiz
J C
JC
Val
J F
JF
Riancho
J A
JA
D000368:Aged; D019867:Anti-Glomerular Basement Membrane Disease / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology; D000936:Antigen-Antibody Complex / Q000032:analysis; D001706:Biopsy; D001989:Bronchiolitis Obliterans / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D017809:Fatal Outcome; D005920:Glomerular Mesangium / Q000276:immunology; D005922:Glomerulonephritis, IGA / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007668:Kidney / Q000473:pathology; D008168:Lung / Q000473:pathology; D008297:Male
D000936:Antigen-Antibody Complex; D007070:Immunoglobulin A