Different effects of levodopa and apomorphine on blink reflex recovery cycle in essential blepharospasm.
With the aim of assessing dopaminergic responsiveness in essential blepharospasm, we investigated the effects of oral levodopa and subcutaneous apomorphine on blink reflex recovery cycle in 7 blepharospasm patients. We found that in blepharospasm the excitability of the blink reflex recovery cycle was increased compared with control subjects. The oral administration of levodopa/carbidopa (500/50 mg) did not significantly modify the blink reflex recovery cycle. The 50 micrograms/kg dose of apomorphine decreased the amplitude of conditioned responses at 300 and 500 ms, whereas the 10 micrograms/kg dose was ineffective. We conclude that the excitability of the blink reflex recovery cycle in blepharospasm is partly under dopaminergic control. The partial normalization of the blink reflex recovery cycle excitability observed with 50 micrograms/kg apomorphine is consistent with the reported clinical efficacy of the drug in this condition.
Napolitano
A
A
Department of Neurosciences, University of Pisa, Italy.
Bonuccelli
U
U
Rossi
B
B
D000284:Administration, Oral; D000328:Adult; D000368:Aged; D001058:Apomorphine / Q000627:therapeutic use*; D001764:Blepharospasm / Q000188:drug therapy* / Q000503:physiopathology; D001767:Blinking / Q000187:drug effects* / Q000502:physiology; D002230:Carbidopa / Q000627:therapeutic use*; D004298:Dopamine / Q000502:physiology; D018491:Dopamine Agonists / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007279:Injections, Subcutaneous; D007980:Levodopa / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D011930:Reaction Time / Q000187:drug effects / Q000502:physiology; D009435:Synaptic Transmission / Q000187:drug effects / Q000502:physiology
D018491:Dopamine Agonists; D007980:Levodopa; D002230:Carbidopa; D001058:Apomorphine; D004298:Dopamine