A new measure of xenobiotic toxicity to the fist-line human defence system from the time-resolved phagocyte luminescence.
A new measure of toxicity based on stochastic modelling of single photon-counting processes, representing time-resolved phagocyte luminescence of xenobiotic-perturbed human neutrophils, has been constructed. The stochastic measure of toxicity has been verified by the QSAR method, and then compared and contrasted with the traditional toxicity measure used in bio- and chemiluminescent research. Phenol and benzene homologues were chosen as perturbers due to their importance from the viewpoint of ecotoxicity and occupational medicine.
Kochel
B
B
Department of Toxicology, Wroclaw University of Medicine, Poland. Kochel@polbox.com
Sajewicz
W
W
D006801:Humans; D008163:Luminescent Measurements; D008433:Mathematics; D008954:Models, Biological; D009504:Neutrophils / Q000187:drug effects / Q000502:physiology*; D010586:Phagocytes / Q000187:drug effects / Q000502:physiology*; D013269:Stochastic Processes; D013997:Time Factors; D015262:Xenobiotics / Q000633:toxicity*
D015262:Xenobiotics