title: Human T-lymphotropic virus type II infection in Vietnamese thalassemic patients.
abstract: Anti-human T-lymphotropic virus type I/II (HTLV-I/II) antibodies were screened by particle agglutination test in a total of 66 patients with thalassemia major who received multiple transfusion from paid donors at the Blood Transfusion Hematology Center of Ho Chi Minh City in South Vietnam. HTLV-II infection was confirmed in 6 patients (9.1%) by Western blot analysis and/or polymerase chain reaction. Phylogenetic analysis revealed that long terminal repeat sequences of HTLV-II proviruses from 5 thalassemic patients in Vietnam belonged to the same phylogenetic subgroup of HTLV-IIb as those from intravenous drug abusers in North America and Europe. These data shed light on the route of introducing HTLV-II into Vietnam.
authors.affiliation: Department of Oncology, Blood Transfusion Hematology Center, Ho Chi Minh City, Vietnam.
authors.forename: M T
authors.initials: MT
authors.lastname: Lin
authors.forename: B T
authors.initials: BT
authors.lastname: Nguyen
authors.forename: T V
authors.initials: TV
authors.lastname: Binh
authors.forename: T V
authors.initials: TV
authors.lastname: Be
authors.forename: T Y
authors.initials: TY
authors.lastname: Chiang
authors.forename: L H
authors.initials: LH
authors.lastname: Tseng
authors.forename: Y C
authors.initials: YC
authors.lastname: Yang
authors.forename: K H
authors.initials: KH
authors.lastname: Lin
authors.forename: Y C
authors.initials: YC
authors.lastname: Chen
mesh_terms: D000293:Adolescent; D000372:Agglutination Tests; D001483:Base Sequence; D002648:Child; D002675:Child, Preschool; D005260:Female; D015686:Gene Products, env / Q000235:genetics; D015752:Genes, env; D015482:HTLV-II Antibodies / Q000097:blood; D015491:HTLV-II Infections / Q000453:epidemiology* / Q000635:transmission / Q000821:virology*; D015367:Human T-lymphotropic virus 2 / Q000145:classification* / Q000235:genetics; D006801:Humans; D007223:Infant; D008297:Male; D008969:Molecular Sequence Data; D010802:Phylogeny; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D015995:Prevalence; D011533:Proviruses / Q000235:genetics; D012091:Repetitive Sequences, Nucleic Acid; D015682:Retroviridae Proteins, Oncogenic / Q000235:genetics; D014744:Vietnam / Q000453:epidemiology; D017086:beta-Thalassemia / Q000150:complications*; D054299:env Gene Products, Human Immunodeficiency Virus
chemical_list: D015686:Gene Products, env; D015482:HTLV-II Antibodies; D015682:Retroviridae Proteins, Oncogenic; D054299:env Gene Products, Human Immunodeficiency Virus; C069569:human T-cell leukemia virus type-II protein gp21