[Malignancy of colorectal cancer analyzed by expression of cyclin D1].
We evaluated the clinical significance of cyclin D1 expression in colorectal adenocarcinoma. One hundred twenty-three specimens resected from patients with colorectal cancers were investigated by staining with a monoclonal antibody against cyclin D1. The possible correlations among cyclin D1 expression, clinicopathologic factors and prognosis were studied. There was no significant association between cyclin D1 expression and various clinicopathological factors. However, disease-free survival was significantly worse in the patients with cyclin D1 strongly positive tumors than in those with cyclin D1 negative tumors. Cyclin D1 overexpression may be useful as a predictor of disease recurrence in patients with colorectal adenocarcinoma.
Maeda
K
K
First Dept. of Surgery, Osaka City University Medical School.
Kang
S M
SM
Ogawa
M
M
Chung
Y S
YS
Onoda
N
N
Nakata
B
B
Nishiguchi
Y
Y
Ikehara
T
T
Okuno
M
M
Sowa
M
M
D000230:Adenocarcinoma / Q000737:chemistry* / Q000401:mortality / Q000556:secondary / Q000601:surgery; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism*; D015179:Colorectal Neoplasms / Q000737:chemistry* / Q000401:mortality / Q000473:pathology / Q000601:surgery; D019938:Cyclin D1; D016213:Cyclins / Q000378:metabolism*; D006801:Humans; D008207:Lymphatic Metastasis; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D015513:Oncogene Proteins / Q000378:metabolism*; D011379:Prognosis; D015996:Survival Rate
D014408:Biomarkers, Tumor; D016213:Cyclins; D015513:Oncogene Proteins; D019938:Cyclin D1