Effectiveness of topical diclofenac in relieving photophobia after pupil dilation.
OBJECTIVE
To test the effectiveness of topical diclofenac in relieving photophobia after pupil dilation.


METHODS
Department of Ophthalmology, Newcastle General Hospital, Newcastle-upon-Tyne, United Kingdom.


METHODS
Twenty healthy patients and volunteers from the outpatient ophthalmology clinic were enrolled in a prospective, double-blind, placebo-controlled comparison in which the patient's fellow eye served as a control. Photophobia after pupil dilation was tested subjectively using a visual analog scale and a neutralization scale at 30 minute intervals for 2 hours after instillation of topical diclofenac.


RESULTS
Both tests show a statistically significant reduction in photophobia in the diclofenac-treated eyes at each time interval (P < or = .05). This difference was also considered clinically relevant.


CONCLUSIONS
Topical diclofenac given at the time of pupil dilation significantly reduced photophobia. The mechanism of action is unknown and requires further evaluation.
Chitkara
D K
DK
Newcastle General Hospital (Chitkara, Jayamanne, Griffiths), Newcastle-upon-Tyne, United Kingdom.
Jayamanne
D G
DG
Griffiths
P G
PG
Fsadni
M G
MG
D000287:Administration, Topical; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D004008:Diclofenac / Q000008:administration & dosage*; D004311:Double-Blind Method; D006801:Humans; D008027:Light; D009184:Mydriatics / Q000008:administration & dosage; D009883:Ophthalmic Solutions; D010656:Phenylephrine / Q000008:administration & dosage; D011446:Prospective Studies; D011680:Pupil / Q000187:drug effects; D016896:Treatment Outcome; D014331:Tropicamide / Q000008:administration & dosage; D014786:Vision Disorders / Q000209:etiology / Q000517:prevention & control*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D009184:Mydriatics; D009883:Ophthalmic Solutions; D004008:Diclofenac; D010656:Phenylephrine; D014331:Tropicamide