title: Endothelin in ischemic acute renal failure.
abstract: The endothelin peptides comprise a family of potent and long-lasting vascoconstrictors, to which the renal microcirculation is particularly susceptible. Increased renal endothelin expression is observed after a variety of injurious stimuli, including ischemia, and persists for days after resolution of the initial injury. Autoinduction of its own production is likely to be a central mechanism underlying endothelin's prolonged effects. Furthermore, antagonizing endothelin reveals its role in maintaining the postischemic glomerular dysfunction that typifies ischemic acute renal failure.
authors.affiliation: Division of Pediatric Nephrology, Vanderbilt University School of Medicine, Nashville, Tenessee 37232-2584, USA.
authors.forename: T E
authors.initials: TE
authors.lastname: Hunley
authors.forename: V
authors.initials: V
authors.lastname: Kon
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology / Q000503:physiopathology*; D000818:Animals; D016232:Endothelins / Q000037:antagonists & inhibitors / Q000502:physiology*; D006801:Humans; D007511:Ischemia / Q000503:physiopathology*; D007668:Kidney / Q000098:blood supply* / Q000293:injuries / Q000503:physiopathology*; D017466:Receptors, Endothelin / Q000502:physiology
chemical_list: D016232:Endothelins; D017466:Receptors, Endothelin