title: Organ-specific autoantibodies in coeliac disease: do they represent an epiphenomenon or the expression of associated autoimmune disorders?
abstract: OBJECTIVE
  The occurrence of autoimmune disorders and organ-specific autoantibodies has been reported in coeliac disease. We assessed the prevalence of organ-specific autoantibodies in coeliac patients and evaluated whether their finding is an expression of associated autoimmune diseases.
  
  
  METHODS
  Sera from 70 coeliac disease patients were tested for thyroid microsomal, gastric parietal cell, adrenal cortex and pancreatic islet cell antibodies by indirect immunofluorescence on O blood group human tissues.
  
  
  RESULTS
  Eighteen coeliacs (26%) were positive for at least one of the autoantibodies studied; thyroid microsomal antibodies showed a higher prevalence (21%) than parietal cell (11%), adrenal cortex (4%) and islet cell antibodies (3%). In 15 (21%) of the 70 coeliacs studied an association with autoimmune diseases was found, including insulin dependent diabetes mellitus (6 cases), autoimmune hepatitis (3 cases), hypothyroidism (4 cases), thyrotoxicosis (1 case) and dermatomyositis (1 case). One or more organ-specific autoantibodies were positive in 12 (80%) of the 15 coeliacs with autoimmune disorders in comparison with their positivity in 6 (11%) of the 55 coeliacs without autoimmune diseases (p < 0.0001).
  
  
  CONCLUSIONS
  The finding of organ-specific autoantibodies in coeliac patients discloses the coexistence of a wide spectrum of immunological diseases.
authors.affiliation: Department of Internal Medicine, Cardiology and Hepatology, University of Bologna, Italy.
authors.forename: U
authors.initials: U
authors.lastname: Volta
authors.forename: L
authors.initials: L
authors.lastname: De Franceschi
authors.forename: N
authors.initials: N
authors.lastname: Molinaro
authors.forename: C
authors.initials: C
authors.lastname: Tetta
authors.forename: F B
authors.initials: FB
authors.lastname: Bianchi
mesh_terms: D000293:Adolescent; D000302:Adrenal Cortex / Q000276:immunology; D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000032:analysis*; D001327:Autoimmune Diseases / Q000150:complications / Q000276:immunology*; D002446:Celiac Disease / Q000150:complications / Q000276:immunology*; D002648:Child; D003882:Dermatomyositis / Q000150:complications; D003922:Diabetes Mellitus, Type 1 / Q000150:complications; D005260:Female; D006505:Hepatitis / Q000150:complications; D006801:Humans; D007037:Hypothyroidism / Q000150:complications; D007515:Islets of Langerhans / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009928:Organ Specificity; D010295:Parietal Cells, Gastric / Q000276:immunology; D013961:Thyroid Gland / Q000276:immunology; D013971:Thyrotoxicosis / Q000150:complications
chemical_list: D001323:Autoantibodies