[Emergency contraception with mifepristone and anordrin].
OBJECTIVE
To study the efficacy of mifepristone or with anordrin for emergency contraception.


METHODS
300 healthy women were recruited within 7.2 hours after unprotected intercourse or contraceptive failure and randomly allocated into 3 groups. Group 1 (n = 100), mifepristone 25 mg twice with 12 hours apart; group 2 (n = 99), single dose of mifepristone 25 mg; and group 3 (n = 101), mifepristone 25 mg and anordrine 7.5 mg given once.


RESULTS
No pregnancy occurred in group 1, while 1 pregnancy in each group 2 and 3. The contraceptive effectiveness were 100.0%, 83.8% and 86.1% for the 3 groups respectively. The overall menstruation disturbances and side effects were low.


CONCLUSIONS
Both mifepristone 50 or 25 mg were effective for emergency contraception and no synergetic effects of anordrin in combination with mifepristone was shown in this study.
Han
X
X
Chaoyang Hospital, Capital University of Medical Science, Beijing.
Weng
L
L
Xiao
B
B
D000328:Adult; D003283:Contraceptives, Postcoital, Synthetic; D004357:Drug Synergism; D005260:Female; D006801:Humans; D015735:Mifepristone; D009635:Norandrostanes; D011247:Pregnancy
D003283:Contraceptives, Postcoital, Synthetic; D009635:Norandrostanes; D015735:Mifepristone; C010855:anordrin