title: A new approach in the management of Crohn's disease: observations in 20 consecutive cases.
abstract: Although the "modern history" of Crohn's disease dates back to 1932, the etiology is still nebulous, the medical treatment inefficient and resective surgery results in a high recurrence rate. Twenty consecutive patients with terminal ileitis underwent ileo-cecal resection and mesenteric-epiploonplasty to enhance collaterals and lymphatic drainage. This approach was advised by experimental observations (the ligation of colonic lymphatic ducts in rabbits), by the intraoperative use of optics to better appreciate the details of the diseased bowel before and after injecting dye and by the angiographic results in one patient. In rabbit experiments, the obliteration of lymphatic drainage led to Crohn's disease-like macroscopic and microscopic patterns, while diffusion of the dye injected in the diseased segment showed altered lymph flow. The angiographic study in one patient confirmed the presence of vascular anomalies. Direct observation through optics revealed large vessels in the serosa with milky contents and the oozing of sticky exudate. In the 8 patients who underwent this procedure over 5 years ago, there were no recurrences. We strongly believe in the vasculo-lymphatic etiology of Crohn's disease and in mesentery-epiploonplasty as the only actual indirect approach to resolve hemolymphatic obstructions.
authors.affiliation: Department of Surgery, University of Bologna, School of Medicine, Italy.
authors.forename: A
authors.initials: A
authors.lastname: del Gaudio
authors.forename: R B
authors.initials: RB
authors.lastname: Bragaglia
authors.forename: L
authors.initials: L
authors.lastname: Boschi
authors.forename: G A
authors.initials: GA
authors.lastname: del Gaudio
authors.forename: D
authors.initials: D
authors.lastname: Accorsi
mesh_terms: D000293:Adolescent; D000792:Angiography; D000818:Animals; D003424:Crohn Disease / Q000175:diagnosis / Q000209:etiology / Q000601:surgery*; D004322:Drainage / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011817:Rabbits; D012008:Recurrence; D016896:Treatment Outcome