title: Physical activity, fibrinogen plasma level and gene polymorphisms in postmenopausal women.
abstract: The relations between habitual physical activity (PA), fibrinogen gene polymorphisms and plasma fibrinogen were investigated in 191 postmenopausal women. Subjects who reported PA at least 4 times/week had lower fibrinogen level (3.19 g/l; 95% CI 3.10; 3.27) than women reporting PA 2-3 times/week (3.43 g/l; 3.29; 3.58) or sedentary subjects (3.64 g/l; 3.33; 3.94). There were no differences in plasma fibrinogen across the alpha-fibrinogen (RsaI, TaqI) or beta-fibrinogen (MnlI, BclI, HindIII) genotypes, the frequencies of which were in a Hardy-Weinberg equilibrium. An interaction between RsaI, which was in complete linkage disequilibrium with TaqI, and PA on plasma fibrinogen was observed, even after adjustments for BMI, smoking and medication (p = 0.024). Among women homozygous for the common RsaI allele, the physically most active had lower fibrinogen level (p <0.001) compared to the physically less active subjects. These results suggest that, in postmenopausal women, the relation between physical activity and plasma fibrinogen is modulated by genetic variation in the alpha-fibrinogen gene.
authors.affiliation: Kuopio Research Institute of Exercise Medicine and Department of Physiology, University of Kuopio, Finland. Rainer.Rauramaa@uku.fi
authors.forename: R
authors.initials: R
authors.lastname: Rauramaa
authors.forename: S
authors.initials: S
authors.lastname: Väisänen
authors.forename: A
authors.initials: A
authors.lastname: Nissinen
authors.forename: T
authors.initials: T
authors.lastname: Rankinen
authors.forename: I
authors.initials: I
authors.lastname: Penttilä
authors.forename: S
authors.initials: S
authors.lastname: Saarikoski
authors.forename: J
authors.initials: J
authors.lastname: Tuomilehto
authors.forename: J
authors.initials: J
authors.lastname: Gagnon
authors.forename: L
authors.initials: L
authors.lastname: Pérusse
authors.forename: C
authors.initials: C
authors.lastname: Bouchard
mesh_terms: D000368:Aged; D005260:Female; D005340:Fibrinogen / Q000235:genetics / Q000378:metabolism; D006801:Humans; D008875:Middle Aged; D010809:Physical Fitness; D011110:Polymorphism, Genetic; D017698:Postmenopause / Q000502:physiology*
chemical_list: D005340:Fibrinogen