[The expression of bcl-2, P53 and c-erbB-2 onco-proteins in breast cancer and their clinicopathological significance].
In order to study the interrelation between bcl-2, P53 and c-erbB-2 protein, their expression in 145 breast carcinomas were observed by immunohistochemical LSAB method. 19 cases were negative, 12 were positive for the three oncoproteins. 19 cases were positive for c-erbB-2 only. 20 positive for P53 only and 20 positive for bcl-2 only. 26 cases were positive for both P53 and c-erbB-2, 17 for both c-erbB-2 and bcl-2, 12 for both P53 and bcl-2. Strong inverse correlation was found between the expression of P53 and bcl-2 (P < 0.001). The P53 expression or the expression of both P53 and c-erbB-2 correlated with low histological grade, while the bcl-2 expression correlated with high histological grade (P < 0.05). The necrosis in tumors with only bcl-2 expression was less than those with c-erbB-2 or both c-erbB-2 and P53 expression (P < 0.02). Mitosis count was lower in tumors with only bcl-2 expression than those with expression of both c-erbB-2 and P53 (P < 0.05). The expression of c-erbB-2 and P53 proteins are associated with poor prognosis (P < 0.02, P < 0.05) but not affected by bcl-2. The results suggest that bcl-2, P53 and c-erbB-2 are involved in tumorigenesis and development of breast carcinoma with different biological effects.
Gao
L
L
Department of Pathology, General Hospital, Beijing Command of PLA.
Ding
H
H
Deng
Y
Y
D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology; D018270:Carcinoma, Ductal, Breast / Q000235:genetics* / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000096:biosynthesis*; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000096:biosynthesis*; D016159:Tumor Suppressor Protein p53 / Q000096:biosynthesis*
D019253:Proto-Oncogene Proteins c-bcl-2; D018719:Erb-b2 Receptor Tyrosine Kinases; D016159:Tumor Suppressor Protein p53