Multiple tumor case: report and analysis of an autopsy case.
An interesting multiple tumor case is described in which 4 different kinds of tumors were diagnosed in the same patient at autopsy and histopathologic examination. The tumors were the following: 1) prolactinoma of the anterior pituitary lobe; 2) basal cell carcinoma of the nose; 3) adenocarcinoma of the colon sigmoideum; 4) multiple oncocytomas (oncocytomatosis) in the kidneys. Immunohistochemical investigation for p53 revealed a strong intranuclear positivity in the colonic carcinoma cells as a result of the overexpression of a possible mutant type of the protein. The other 3 tumors were negative with the p53-specific DO-7 antibody, therefore, no point mutation was thought to be present in the p53 gene of the tumor cells. The immunohistochemical and anamnestic data suggested that this is not a hereditary syndrome, and there is no common pathogenesis of these tumors. Its rarity is interesting in our case because of the coincidence of 4 different unrelated tumors and the absence of anamnestic data for familial accumulation or predisposition for multiple tumors.
Tornóczky
T
T
Department of Pathology, University Medical School of Pécs, Hungary.
Szuhai
K
K
D000230:Adenocarcinoma; D018249:Adenoma, Oxyphilic; D000368:Aged; D000369:Aged, 80 and over; D001344:Autopsy; D002280:Basal Cell Carcinoma; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007680:Kidney Neoplasms; D009363:Neoplasm Proteins / Q000032:analysis; D009378:Neoplasms, Multiple Primary / Q000473:pathology*; D009666:Nose; D009687:Nuclear Proteins / Q000032:analysis; D010911:Pituitary Neoplasms; D015175:Prolactinoma; D012811:Sigmoid Neoplasms; D012878:Skin Neoplasms; D016159:Tumor Suppressor Protein p53 / Q000032:analysis
D009363:Neoplasm Proteins; D009687:Nuclear Proteins; D016159:Tumor Suppressor Protein p53