[The efficacy of and tolerance for ketoprofen lysine salt in solution for oropharyngeal use in inflammatory lesions of the oral cavity].
BACKGROUND
A double blind randomized comparative clinical study vs placebo clinical study has been carried out in order to assess the antiinflammatory and analgesic activity of ketoprofen lysine salt in oropharyngeal solution, in pain-inflammatory pathologies of odontostomatological nature.


METHODS
One hundred and twenty patients, aged between 18 and 82 years, were recruited for the purpose and assigned at random to treatment with ketoprofen lysine salt or placebo for a period of 7 days.


CONCLUSIONS
Treatment with ketoprofen lysine salt demonstrated a significantly more marked (p < 0.001) anti-inflammatory effect than placebo as regards all variables considered: burning, sensation pain, oedema and erythema, and by the 3rd day of treatment led to significant remission of the symptomatology. Tolerability of ketoprofen lysine salt was excellent.
Natale
F
F
Presidio Specialistico Extraospedaliero, USSL n. 21, Mantova.
de' Lorenzi
C
C
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D004311:Double-Blind Method; D004361:Drug Tolerance; D005260:Female; D006801:Humans; D007660:Ketoprofen / Q000031:analogs & derivatives* / Q000627:therapeutic use; D008239:Lysine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009067:Mouthwashes / Q000627:therapeutic use*; D012074:Remission Induction; D013280:Stomatitis / Q000188:drug therapy*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D009067:Mouthwashes; C029946:ketoprofen lysine; D007660:Ketoprofen; D008239:Lysine