title: Reinfusion of concentrated ascitic fluid versus total paracentesis. A randomized prospective trial.
abstract: We compared the efficacy and safety of apheresis and reinfusion of concentrated ascites (ARCA) versus total paracentesis plus intravenous albumin (PARA) in a prospective trial on cirrhotic patients with tense ascites. Twenty-four patients were randomized to either ARCA (N = 12) or PARA (N = 12), and followed for two years. Sex, age, Child's class, and renal and liver function were similar in the two groups. The times the procedures were 2.7 +/- 1.0 (ARCA) vs 2.2 +/- 1.1 (PARA) hr, with removal of 8.8 +/- 3.5 (ARCA) and 6.9 +/- 3.4 (PARA) liters of ascites and intravenous infusion of 59.8 +/- 35.2 (ARCA) and 42.5 +/- 20.5 (PARA) g of albumin. Both procedures were safe. Biochemical signs of coagulative disturbances having no clinical relevance were observed after ARCA, with an increase in prothrombin time (P = 0.005) and serum FSP (P = 0.02). No significant changes in renal function, serum albumin, or plasma and urinary electrocytes were shown. Plasma renin activity increased after PARA (P = 0.02) and plasma atrial natriuretic factor increased after ARCA (P = 0.008), although no differences were observed in diuresis in the immediate follow-up. During the long-term follow-up, patient survival and recurrence of tense ascites were the same in both groups. We conclude that apheresis and reinfusion of concentrated ascites are as safe and effective as total paracentesis with albumin infusion for the treatment of tense ascites in cirrhotic patients.
authors.affiliation: Division of Gastroenterology, School of Medicine, University of Padova, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Graziotto
authors.forename: L
authors.initials: L
authors.lastname: Rossaro
authors.forename: P
authors.initials: P
authors.lastname: Inturri
authors.forename: M
authors.initials: M
authors.lastname: Salvagnini
mesh_terms: D000328:Adult; D000368:Aged; D001201:Ascites / Q000628:therapy*; D001202:Ascitic Fluid; D009320:Atrial Natriuretic Factor / Q000097:blood; D001781:Blood Component Removal; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008103:Liver Cirrhosis / Q000097:blood / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D019152:Paracentesis; D011446:Prospective Studies; D012008:Recurrence; D012083:Renin / Q000097:blood; D012709:Serum Albumin / Q000008:administration & dosage
chemical_list: D012709:Serum Albumin; D009320:Atrial Natriuretic Factor; D012083:Renin