Dietary restriction affects antioxidant levels in rat liver mitochondria during ageing.
Six experimental groups of young (7-month-old) and aged (24-32-month-old) rats, underwent different dietary manipulations (i.e. dietary restriction and/or a vitamin E-depleted diet), and their liver mitochondria were assayed for several antioxidants and peroxidation markers. Glutathione levels were affected both by age and dietary treatment. Coenzyme Q9 and C0Q10 showed the highest levels in the oldest rats where ageing, as well as other oxidative stresses, could induce ubiquinone biosynthesis.
Armeni
T
T
Institute of Genetics and Biology, University of Ancona, Italy.
Tomasetti
M
M
Svegliati Baroni
S
S
Saccucci
F
F
Marra
M
M
Pieri
C
C
Littarru
G P
GP
Principato
G
G
Battino
M
M
D000375:Aging / Q000378:metabolism*; D000818:Animals; D000975:Antioxidants / Q000032:analysis*; D003067:Coenzymes; D005508:Food Deprivation; D005978:Glutathione / Q000032:analysis; D006861:Hydrogen Peroxide / Q000032:analysis; D015227:Lipid Peroxidation; D008136:Longevity; D008930:Mitochondria, Liver / Q000378:metabolism*; D018384:Oxidative Stress; D051381:Rats; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000032:analysis*; D014811:Vitamin E Deficiency / Q000378:metabolism
D000975:Antioxidants; D003067:Coenzymes; D014451:Ubiquinone; D006861:Hydrogen Peroxide; C024989:coenzyme Q10; D005978:Glutathione; C030571:ubiquinone 9