title: L-threonine injection into PPC modifies food intake, lateral hypothalamic activity, and sympathetic discharge.
abstract: Food intake and the firing rate of lateral hypothalamic neurons and nerves innervating interscapular brown adipose tissue (IBAT), along with IBAT and colonic temperatures, were monitored in male Sprague-Dawley rats fed a threonine-free diet. These variables were measured before and after a bilateral injection of L-threonine (2 nmol into each side) into the prepiriform cortex (PPC). The same variables were also monitored in 1) rats fed a threonine-free diet and injected with saline, 2) animals fed a standard diet and injected with L-threonine, and 3) rats fed a standard diet and injected with saline. The results showed that injection of L-threonine into PPC increases food intake and firing rate of lateral hypothalamic neurons, whereas it decreases the sympathetic discharge and body temperature in animals fed a threonine-free diet. No changes were found in the animals fed a standard diet. These findings suggest a correlation between 1) threonine level in the PPC and 2) lateral hypothalamic activity and sympathetic discharge to IBAT.
authors.affiliation: Dipartimento di Fisiologia Umana, Seconda Università di Napoli, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Monda
authors.forename: A
authors.initials: A
authors.lastname: Sullo
authors.forename: V
authors.initials: V
authors.lastname: De Luca
authors.forename: M P
authors.initials: MP
authors.lastname: Pellicano
authors.forename: A
authors.initials: A
authors.lastname: Viggiano
mesh_terms: D002001:Adipose Tissue, Brown / Q000294:innervation; D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D004435:Eating / Q000187:drug effects* / Q000502:physiology; D004594:Electrophysiology; D007026:Hypothalamic Area, Lateral / Q000187:drug effects* / Q000502:physiology; D007267:Injections; D008297:Male; D009833:Olfactory Pathways / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013564:Sympathetic Nervous System / Q000187:drug effects* / Q000502:physiology; D013912:Threonine / Q000494:pharmacology*
chemical_list: D013912:Threonine