title: The effect of supplemental oxygen on the incidence of hypoxaemia after premedication in patients undergoing cardiac surgery.
abstract: Opiate premedication may cause significant respiratory depression, particularly when other sedative agents such as scopolamine or benzodiazepines are added. This can cause hypoxaemia with potential for worsening myocardial ischaemia in cardiac surgery patients. The aim of this study was to investigate the incidence of hypoxaemia (SpO2 < 90%) in elective patients undergoing cardiac surgery and to assess the efficacy of supplemental oxygen in preventing it. One hundred elective patients without significant respiratory disease or cardiac failure, who received both an opiate and a sedative premedication, were prospectively randomized to receive either oxygen via a facemask at 4 l/min or no oxygen. Continuous arterial oxygen saturation was recorded using a pulse oximeter from the time of premedication until the patient arrived in theatre. An SpO2 < 90% was recorded as a significant event and oxygen was administered to the patients. Six patients were excluded because of equipment failure or protocol violations. The patient groups were comparable with respect to patient demographics, premedication type and dose or the duration of monitoring. In patients receiving oxygen (n = 48) there were no episodes of hypoxaemia (0%). In patients not receiving oxygen (n = 46) there were 14 episodes of hypoxaemia (30%, P < 0.0001). We conclude that there is a significantly high incidence of hypoxaemia in cardiac surgery patients following combined opiate and sedative premedication and that it can be reduced by the routine administration of supplemental oxygen.
authors.affiliation: Department of Anaesthesia, Royal Melbourne Hospital, Victoria.
authors.forename: C F
authors.initials: CF
authors.lastname: Royse
authors.forename: R J
authors.initials: RJ
authors.lastname: Tiernan
authors.forename: S M
authors.initials: SM
authors.lastname: Portelli
authors.forename: S
authors.initials: S
authors.lastname: Davies
authors.forename: R
authors.initials: R
authors.lastname: Arblaster
authors.forename: A R
authors.initials: AR
authors.lastname: Bjorksten
authors.forename: J
authors.initials: J
authors.lastname: Tatoulis
mesh_terms: D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000009:adverse effects; D006348:Cardiac Surgical Procedures; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage / Q000009:adverse effects; D000860:Hypoxia / Q000139:chemically induced / Q000517:prevention & control*; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D010102:Oxygen Inhalation Therapy; D011229:Preanesthetic Medication; D011446:Prospective Studies
chemical_list: D000701:Analgesics, Opioid; D006993:Hypnotics and Sedatives; D010100:Oxygen