Structure and function of platelet alpha IIb beta 3.
Platelet aggregation is mediated by the platelet fibrinogen receptor, the alpha IIb beta 3 integrin (glycoprotein IIb-IIIa). This integrin has served as a prototype for studies probing structure-function relationships, cellular modulation of integrin function, and integrin-mediated signaling. Use of new model systems and molecular approaches have helped investigators to make rapid progress in our understanding of these areas, as reviewed here.
Naik
U P
UP
Department of Pharmacology, University of North Carolina, Chapel Hill 27599, USA.
Parise
L V
LV
D000818:Animals; D006801:Humans; D008024:Ligands; D008958:Models, Molecular; D010974:Platelet Aggregation; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000737:chemistry*; D015398:Signal Transduction; D013329:Structure-Activity Relationship
D008024:Ligands; D019039:Platelet Glycoprotein GPIIb-IIIa Complex