The role of lipid signaling in constitutive membrane traffic.
Several lines of evidence indicate that enzymes that modify membrane lipids function in the regulation of constitutive membrane traffic. Recent evidence suggests that specific phosphatidylinositides may regulate the activity of proteins with diverse functions in membrane transport, such as dynamin, the clathrin-associated AP-2 complex, and proteins that stimulate guanine nucleotide exchange on ADP-ribosylation factors (ARFs). ARF proteins activate a phospholipase D that produces phosphatidic acid from phosphatidylcholine, and this may be essential for the formation of certain types of transport vesicles or may be constitutive vesicular transport to signal transduction pathways.
Roth
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MG
Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas 75235-9038, USA. mroth@biochem.swmed.edu
Sternweis
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PC
D020727:ADP-Ribosylation Factors; D000818:Animals; D002462:Cell Membrane / Q000502:physiology*; D002966:Clathrin / Q000502:physiology; D004268:DNA-Binding Proteins / Q000378:metabolism; D019204:GTP-Binding Proteins / Q000378:metabolism; D006150:Guanine Nucleotides / Q000378:metabolism; D007425:Intracellular Membranes / Q000502:physiology*; D008563:Membrane Lipids / Q000502:physiology*; D008565:Membrane Proteins / Q000502:physiology*; D008954:Models, Biological; D010716:Phosphatidylinositols / Q000378:metabolism; D010739:Phospholipase D / Q000378:metabolism; D015398:Signal Transduction; D050656:Transcription Factor AP-2; D014157:Transcription Factors / Q000378:metabolism
D002966:Clathrin; D004268:DNA-Binding Proteins; D006150:Guanine Nucleotides; D008563:Membrane Lipids; D008565:Membrane Proteins; D010716:Phosphatidylinositols; D050656:Transcription Factor AP-2; D014157:Transcription Factors; D010739:Phospholipase D; D019204:GTP-Binding Proteins; D020727:ADP-Ribosylation Factors