Protein kinase C and phospholipase C: bilayer interactions and regulation.
Protein kinase C and phospholipase C are interfacially active modular enzymes that contain multiple membrane-binding domains. During the past two years, 3D structures and functional data have been reported for the key domains: pleckstrin homology, protein kinase C homology-1 and -2, and the phospholipase C catalytic domain. Roles for membrane bilayer structure and lipid microdomains have become clearly domains has shown how the domains work together to coordinate regulation.
Hurley
J H
JH
Laboratory of Molecular Biology, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-0580, USA. Hurley@tove.niddk.nih.gov
Grobler
J A
JA
D008051:Lipid Bilayers / Q000737:chemistry*; D008958:Models, Molecular; D011493:Protein Kinase C / Q000737:chemistry*; D017386:Sequence Homology, Amino Acid; D010738:Type C Phospholipases / Q000737:chemistry*
D008051:Lipid Bilayers; D011493:Protein Kinase C; D010738:Type C Phospholipases