New types of K+ channels in the colon.
The mechanism of epithelial Cl- secretion requires K+ recycling via basolateral ion channels. Two types of K+ channels were identified. A Ca(2+)-activated, and a very small cAMP-regulated K+ channel. Increase of cAMP inhibits the Ca(2+)-activated K+ channel and thus makes small K+ channel the limiting step for cAMP-dependent Cl- secretion.
Greger
R
R
Physiologisches Institut, Albert-Ludwigs-Universität, Freiburg, Federal Republic of Germany.
Bleich
M
M
Warth
R
R
D000818:Animals; D002118:Calcium / Q000502:physiology; D002478:Cells, Cultured; D002712:Chlorides / Q000378:metabolism; D003106:Colon / Q000502:physiology*; D000242:Cyclic AMP / Q000502:physiology; D007413:Intestinal Mucosa / Q000502:physiology*; D018408:Patch-Clamp Techniques; D011188:Potassium / Q000378:metabolism; D015221:Potassium Channels / Q000145:classification / Q000502:physiology*; D051381:Rats; D014882:Water-Electrolyte Balance / Q000502:physiology*
D002712:Chlorides; D015221:Potassium Channels; D000242:Cyclic AMP; D011188:Potassium; D002118:Calcium