Postejaculation serum prostate-specific antigen level.
OBJECTIVE
This study was carried out to determine whether ejaculation may modify the serum prostate-specific antigen (PSA) level and to investigate whether postejaculation serum PSA may play a role in male hypofertility work-up.


METHODS
Serum PSA concentration was determined before and 1 h after ejaculation in 18 healthy men (group A) and in 16 men with male-factor infertility (group B). PSA change (delta) was recorded and analyzed.


RESULTS
Postejaculation serum PSA differed significantly from basal levels (p = 0.0037 by the Wilcoxon signed rank test). Following ejaculation, a rise was noticed in 74% of subjects. The median relative change in PSA concentration was 54%. No difference in respect to mean, median and relative change was observed between study groups. In two cases (6%), PSA rose from normal level to more than 4 ng/ml.


CONCLUSIONS
A significant postejaculation serum PSA elevation does occur, it is thus recommended that men abstain from ejaculation for 24 h prior to PSA sampling. Postejaculation PSA was not found to significantly correlate with hypofertility.
Zisman
A
A
Department of Urology, Assaf Harofeh Medical Center, Zerifin, Israel.
Soffer
Y
Y
Siegel
Y I
YI
Paz
A
A
Lindner
A
A
D000328:Adult; D004542:Ejaculation / Q000502:physiology*; D006801:Humans; D007248:Infertility, Male / Q000097:blood* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D017430:Prostate-Specific Antigen / Q000097:blood*; D013076:Sperm Count
D017430:Prostate-Specific Antigen