[Using ligustrazini and angelica sinensis treat the bleomycin-induced pulmonary fibrosis in rats].
OBJECTIVE
To seek a kind of Chinese traditional medicine to treat the bleomycin-induced pulmonary fibrosis.


METHODS
SD rats with bleomycin A(s) induced pulmonary fibrosis, were divided into 4 groups. Normal control group (10 rats), untreated model group (35 rats), ligustrazini group (10 rats), Angelica sinensis group (10 rats). Both ligustrazini and angelica sinensis were given intraperitoneally by injection daily for 28 days. Then all rats were put to death and took out the lungs for examination. Using histopathological examination and image processing computer assisted to evaluate the result of treatments.


RESULTS
Ligustrazini could obviously reduced alveolitis and fibrosis and Angelica sinensis had the similar but lesser result.


CONCLUSIONS
Ligustrazini and angelica sinensis have successful result of treatment for pulmonary fibrosis.
Dai
L
L
Drum Tower Hospital, Nanjing.
Hou
J
J
Cai
H
H
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D001761:Bleomycin; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D007091:Image Processing, Computer-Assisted; D008297:Male; D011658:Pulmonary Fibrosis / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D011719:Pyrazines / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004365:Drugs, Chinese Herbal; D011719:Pyrazines; D001761:Bleomycin; C017953:tetramethylpyrazine