title: Infradiaphragmatic Hodgkin's disease.
abstract: Between 1968 and 1994, 133 patients with stages I and II supradiaphragmatic Hodgkin's disease were evaluated at our institution. During the same period we treated only 11 patients with stages I and II infradiaphragmatic Hodgkin's disease. When compared to patients with disease above the diaphragm, patients with Hodgkin's disease below the diaphragm were more frequently male (p < 0.05), were generally older (46.3 vs 40.1 years, but the difference was not significant), had a higher incidence of systemic symptoms (p < 0.05), and had predominantly histologic subtypes with mixed cellularity and lymphocyte predominance. Primary treatment included inverted Y radiotherapy in 3 patients, polychemotherapy in 6, and combined treatment in 2. Ten patients achieved complete response. Five- and ten-year survival rates were 90% and 67.5%, respectively. There was no difference in survival rate between patients with infradiaphragmatic and supradiaphragmatic Hodgkin's disease receiving similar treatment.
authors.affiliation: 3rd Department of Medicine, University Medical School of Debrecen, Hungary.
authors.forename: A
authors.initials: A
authors.lastname: Illés
authors.forename: G
authors.initials: G
authors.lastname: Vadász
authors.forename: A
authors.initials: A
authors.lastname: Bányai
authors.forename: G
authors.initials: G
authors.lastname: Szegedi
mesh_terms: D000328:Adult; D000368:Aged; D003131:Combined Modality Therapy; D003964:Diaphragm / Q000473:pathology* / Q000503:physiopathology; D005260:Female; D006689:Hodgkin Disease / Q000401:mortality / Q000473:pathology / Q000503:physiopathology* / Q000628:therapy; D006801:Humans; D008297:Male; D008875:Middle Aged