Brain-mediated protective interactions of histaminergic H2 and dopaminergic systems in rats.
Pretreatment with dopamine agonists (bromocriptine 2.5, L-dopa 2.5, apomorphine 0.05 mg/kg i.p.) and a histamine H2 receptor antagonist (cimetidine 50.0 mg/kg i.p.) was found to greatly reduce the haemorrhagic gastric lesions induced by 15-min pylorus ligation in rats. On the other hand, pretreatment with dopamine antagonists (haloperidol 5.0, sulpiride 1.0, domperidone 5.0 mg/kg i.p.) significantly aggravated these lesions. Cimetidine markedly diminished the ulcerogenic effect of haloperidol but not that of domperidone, suggesting a brain-mediated site for the protective interaction of cimetidine and dopamine systems.
Grabarević
Z
Z
Department of General Pathology and Pathological Morphology, Veterinary Faculty, University of Zagreb, Croatia.
Rotkvić
I
I
Sikirić
P
P
Seiwerth
S
S
Dzaja
P
P
Perić
J
J
Kos
J
J
D000818:Animals; D001058:Apomorphine / Q000008:administration & dosage / Q000494:pharmacology; D001971:Bromocriptine / Q000008:administration & dosage / Q000494:pharmacology; D002927:Cimetidine / Q000008:administration & dosage / Q000494:pharmacology*; D004294:Domperidone / Q000008:administration & dosage / Q000494:pharmacology; D018491:Dopamine Agonists / Q000008:administration & dosage / Q000494:pharmacology*; D018492:Dopamine Antagonists / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D006635:Histamine H2 Antagonists / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D010438:Peptic Ulcer Hemorrhage / Q000188:drug therapy*; D051381:Rats; D017208:Rats, Wistar; D013276:Stomach Ulcer / Q000150:complications / Q000188:drug therapy*; D013469:Sulpiride / Q000008:administration & dosage / Q000494:pharmacology
D018491:Dopamine Agonists; D018492:Dopamine Antagonists; D006635:Histamine H2 Antagonists; D001971:Bromocriptine; D004294:Domperidone; D013469:Sulpiride; D002927:Cimetidine; D001058:Apomorphine