Design of a method for in vitro studies of polymer adhesion.
In this paper we describe a modified intestinal perfusion technique for investigation of bioadhesion phenomena. This technique is an in vitro method with well standardized experimental conditions which measures the intestinal intraluminal pressure and its oscillation. This also allows the vitality of the intestinal segment used in the experimental to be checked. Our results suggest that the longest adhesion occurred with polyacrylic acid, in comparison with carboxymethylcellulose sodium and the shortest with hydroxypropylcellulose.
Cvetković
N
N
ICN Galenika-Institute, Belgrade, Yugoslavia.
Nesić
M
M
Moracić
V
V
Rosić
M
M
D000268:Adhesiveness; D000818:Animals; D002266:Carboxymethylcellulose Sodium; D002482:Cellulose / Q000031:analogs & derivatives; D007413:Intestinal Mucosa / Q000378:metabolism; D010477:Perfusion; D011108:Polymers / Q000737:chemistry*; D051381:Rats; D013607:Tablets
D011108:Polymers; D013607:Tablets; D002482:Cellulose; C008079:hydroxypropylcellulose; D002266:Carboxymethylcellulose Sodium