title: Kinetics of selenium incorporation into tissues of female mallard ducks.
abstract: Selenium is essential for both mammalian and avian species, although its metabolism in birds has been less thoroughly studied. Little information has been available on the kinetics of selenium in birds, especially as it relates to the teratogenicity seen in waterfowl consuming excessive amounts. This study describes the pharmacokinetics of small amounts of 75Se as selenious acid injected into female mallard ducks. Labeled selenium was injected into a wing vein of restrained animals and tissues taken at five different time points up to 24 h post-injection. Selenium levels as percent of injected dose were determined in liver, kidney, heart, lung, adrenals, thyroid, spleen, pancreas, ovaries, intestine, muscle and plasma. Estimates of kinetic parameters (uptake and elimination rates, time of maximum concentration and maximum concentration) were obtained with a non-linear kinetics computer program (PCNONLIN, SCI Software, Lexington, KY). Results showed four basic patterns of distribution, uptake and elimination. Visceral tissues exhibited a triphasic pattern with a rapid rise, a decline followed by a distinctive increase in levels between the last two time points. Brain uptake was continuous over the 24 h. Plasma rose rapidly and then declined to a constant level. The ovaries as a tissue of interest relating to the teratogenic effects of selenium showed the greatest relative increase at 24 h, suggesting kinetic mechanisms consistent with a pathway that might lead to accumulation of toxic levels and teratogenic effects during embryo development.
authors.affiliation: Department of Nutrition/142, University of Nevada, Reno 89557-0132, USA.
authors.forename: D S
authors.initials: DS
authors.lastname: Wilson
authors.forename: P
authors.initials: P
authors.lastname: Zhang
authors.forename: R
authors.initials: R
authors.lastname: He
authors.forename: R
authors.initials: R
authors.lastname: Ota
authors.forename: S T
authors.initials: ST
authors.lastname: Omaye
mesh_terms: D000818:Animals; D004372:Ducks; D005260:Female; D007275:Injections, Intravenous; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D010179:Pancreas / Q000378:metabolism; D012643:Selenium / Q000008:administration & dosage / Q000493:pharmacokinetics*; D013154:Spleen / Q000378:metabolism; D013723:Teratogens / Q000493:pharmacokinetics; D014018:Tissue Distribution
chemical_list: D013723:Teratogens; D012643:Selenium