N-type calcium channel blockers from a marine bacterium, Cytophaga sp. SANK 71996.
N-(3-Acyloxyacyl)glycines were isolated as N-type calcium channel blockers from a marine bacterium Cytophaga sp. SANK 71996. The identification and fermentation of the producing strain and structure characterization of N-(3-acyloxyacyl)glycines by spectral analyses and chemical syntheses are described together with their antagonistic activities.
Morishita
T
T
Biomedical Research Laboratories, Sankyo Co., Ltd., Tokyo, Japan.
Sato
A
A
Hisamoto
M
M
Oda
T
T
Matsuda
K
K
Ishii
A
A
Kodama
K
K
D000818:Animals; D002121:Calcium Channel Blockers / Q000302:isolation & purification / Q000378:metabolism* / Q000494:pharmacology*; D015220:Calcium Channels / Q000187:drug effects*; D003589:Cytophaga / Q000737:chemistry* / Q000145:classification / Q000378:metabolism*; D005285:Fermentation; D005998:Glycine / Q000096:biosynthesis* / Q000302:isolation & purification / Q000494:pharmacology*; D011817:Rabbits; D013329:Structure-Activity Relationship
D002121:Calcium Channel Blockers; D015220:Calcium Channels; D005998:Glycine