title: [Physiological and pharmacological activities of simple alkyl- and arylpyrazines].
abstract: This review describes the physiological and pharmacological effect of simple alkyl- and arylpyrazines. The description is made in the following order 1) the presence of 2,5-dimethylpyrazine in the urine samples of human being and rodents 2) the effects of tetramethyl- and tetraethylpyrazines on the vascular smooth muscles 3) the activity of alkyl- and arylpyrazines on the aggregation of arachidonic acid- and collagen-induced platelets 4) the effects of 2,5-dimethylpyrazine on the reproductive and the accessory reproductive organs of female and male rats 5) the effects of 2,5-dimethylpyrazine on the plasma and on the contents of polyamines and fructose in the accessory reproductive organs of rats.
authors.affiliation: School of Pharmacy, Tokyo University of Pharmacy and Life Science, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Ohta
authors.forename: K
authors.initials: K
authors.lastname: Yamada
mesh_terms: D000818:Animals; D005260:Female; D005632:Fructose / Q000378:metabolism; D006066:Gonads / Q000378:metabolism; D006801:Humans; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects; D011073:Polyamines / Q000378:metabolism; D011719:Pyrazines / Q000494:pharmacology; D051381:Rats; D012098:Reproduction / Q000187:drug effects; D014661:Vasoconstriction / Q000187:drug effects
chemical_list: D011073:Polyamines; D011719:Pyrazines; D005632:Fructose; C072829:tetraethylpyrazine; C017953:tetramethylpyrazine; C075524:2,5-dimethylpyrazine