title: Relationship between some humoral factors and left ventricular hypertrophy in essential hypertension.
abstract: OBJECTIVE
  To evaluate the relationship between certain humoral factors and left ventricular hypertrophy (LVH) in essential hypertension.
  
  
  METHODS
  62 essential hypertension (EH) patients (32 men, 30 women; mean age, 55 years) and 20 normotensive healthy subjects (10 men, 10 women: mean age, 52 years) were studied. EH patients were divided into LVH group and non-LVH group by echocardiography. After an overnight fast, blood samples were taken for the determination of parathyroid hormone (PTH), angiotensin II (ATII) and aldosterone (ALD) by radioimmunoassay.
  
  
  RESULTS
  There was a significant difference in PTH. AT II and ALD between the EH group and control group. Furthermore, in LVH group PTH, ATII and ALD elevated significantly as compared with non-LVH group. In addition, we found that LVMI (left ventricular mass index) correlated with ATII (r = 0.342, P < 0.01) and ALD (r = 0.356, P < 0.01). There was a more significant correlation between LVMI and PTH (r = 0.422, P < 0.0025).
  
  
  CONCLUSIONS
  Some humoral factors are important determinants of LV mass. Besides the reninangiotensin-aldosterone system, PTH might play an important role in cardiac hypertrophy.
authors.affiliation: Department of Cardiovascular Medicine, Electric Power General Hospital, Beijing.
authors.forename: Y
authors.initials: Y
authors.lastname: Hui
authors.forename: Y
authors.initials: Y
authors.lastname: Hao
authors.forename: X
authors.initials: X
authors.lastname: Chen
authors.forename: S
authors.initials: S
authors.lastname: Jing
authors.forename: Z
authors.initials: Z
authors.lastname: Dai
mesh_terms: D000450:Aldosterone / Q000097:blood; D000804:Angiotensin II / Q000097:blood; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000150:complications; D017379:Hypertrophy, Left Ventricular / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood*; D012084:Renin-Angiotensin System
chemical_list: D010281:Parathyroid Hormone; D000804:Angiotensin II; D000450:Aldosterone