title: Fluconazole treatment of neonates and infants with severe fungal infections.
abstract: A total of 24 neonates and infants, aged from 2 days to 10 months, received treatment with intravenous fluconazole for microbiologically documented or presumed fungal infection. The mean fluconazole dosage was 6 mg/kg/day (range 2-16 mg/kg/day) and the mean duration of therapy was 25 days (range 5-72 days). Efficacy was evaluated in neonates with proven fungal infections, as documented by the presence of pathogen at baseline. A positive clinical response was achieved in 23 of the 24 clinically evaluable patients (96%); eradication of the fungal organism was also achieved in 23 of the 24 evaluable patients (96%). Adverse events occurred in two patients (8%) but therapy was not discontinued in either patient. The present results confirm the efficacy and safety of fluconazole in the treatment of neonates and infants with severe fungal infections.
authors.affiliation: Department of Paediatric Surgery, Uludağ University Medical Faculty, Bursa, Turkey.
authors.forename: A N
authors.initials: AN
authors.lastname: Gürpinar
authors.forename: E
authors.initials: E
authors.lastname: Balkan
authors.forename: N
authors.initials: N
authors.lastname: Kiliç
authors.forename: I
authors.initials: I
authors.lastname: Kiriştioğlu
authors.forename: I
authors.initials: I
authors.lastname: Avşar
authors.forename: H
authors.initials: H
authors.lastname: Doğruyol
mesh_terms: D000935:Antifungal Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D015725:Fluconazole / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007262:Infusions, Intravenous; D008297:Male; D009181:Mycoses / Q000188:drug therapy* / Q000382:microbiology; D012449:Safety
chemical_list: D000935:Antifungal Agents; D015725:Fluconazole