Diclofenac: a new trigger of pemphigus vulgaris?
Many drugs have been shown to induce pemphigus, including thiol and nonthiol drugs. We present a case of pemphigus vulgaris where a nonsteroidal anti-inflammatory medication, diclofenac in suppositories and topical gel preparations, is suspected of having triggered the disease. The temporal relationship between drug and outbreak of disease together with the positive migration inhibition factor test to diclofenac point to the possible involvement of this drug in triggering pemphigus vulgaris.
Matz
H
H
Department of Dermatology, Tel Aviv Sourasky Medical Center, Israel.
Bialy-Golan
A
A
Brenner
S
S
D000279:Administration, Cutaneous; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000009:adverse effects*; D004008:Diclofenac / Q000008:administration & dosage / Q000009:adverse effects*; D003875:Drug Eruptions / Q000209:etiology*; D005260:Female; D005782:Gels; D006801:Humans; D007961:Leukocyte Migration-Inhibitory Factors; D008214:Lymphocytes / Q000187:drug effects; D009059:Mouth Diseases / Q000139:chemically induced*; D009297:Nasal Mucosa / Q000187:drug effects; D009668:Nose Diseases / Q000139:chemically induced; D019226:Oral Ulcer / Q000139:chemically induced; D010392:Pemphigus / Q000139:chemically induced*; D010608:Pharyngeal Diseases / Q000139:chemically induced; D013488:Suppositories; D013997:Time Factors
D000894:Anti-Inflammatory Agents, Non-Steroidal; D005782:Gels; D007961:Leukocyte Migration-Inhibitory Factors; D013488:Suppositories; D004008:Diclofenac