title: Unusual acute and chronic complications of malaria.
abstract: 32 cases (21 acute severe malaria and 11 chronic malaria syndrome), who developed unusual complications and/or manifestations are reported. The acute manifestations were unexplained tachypnoea 4, pulmonary oedema 5 and shock due to multiple organ dysfunction syndrome 3, melena 2 and E coli septicaemia in one. The other features were concomitant salmonellosis 2, meningitis 1, renal failure 3, hepatorenal syndrome 2, hepatitis like illness 7, neck stiffness with normal CSF 3, urticaria and subconiunctival haemorrhage 2 each, apyrexial spell with anaemia 4, thromocytopenia 3, and hypoglycaemia 3 (two pretreatment and one while on quinine in 5% glucose drip). The chronic syndrome noted were hyperreactive malaria syndrome (Tropical splenomegaly) 3, repeated haemolysis 2, chronic simple malaria with positive parasitaemia and normal Igm levels 4, and cerebellar ataxia with tremors 3. Bone marrow in these cases was hypercullular with increase plasma cells. Liver biopsy revealed lymphocytic infiltration. There was no case with permanent neurogical deficit. All patients with pulmonary oedema and multiple organ dysfunction died but chronic syndrome patients recovered fully. Early recoginition of atypical manifestation and prompt treatment will decrease the mortality and morbidity due to malaria.
authors.affiliation: Medical Division, Army Hospital, Delhi.
authors.forename: S R
authors.initials: SR
authors.lastname: Metha
authors.forename: V
authors.initials: V
authors.lastname: Joshi
authors.forename: A I
authors.initials: AI
authors.lastname: Lazar
mesh_terms: D000208:Acute Disease; D058186:Acute Kidney Injury / Q000175:diagnosis / Q000469:parasitology* / Q000628:therapy; D000293:Adolescent; D000328:Adult; D000818:Animals; D000962:Antimalarials / Q000627:therapeutic use; D001706:Biopsy; D002648:Child; D002908:Chronic Disease; D004912:Erythrocytes / Q000469:parasitology; D005260:Female; D006505:Hepatitis / Q000175:diagnosis / Q000188:drug therapy / Q000469:parasitology*; D006801:Humans; D016778:Malaria, Falciparum / Q000150:complications* / Q000469:parasitology / Q000628:therapy; D016780:Malaria, Vivax / Q000150:complications / Q000469:parasitology; D008297:Male; D008875:Middle Aged; D010963:Plasmodium falciparum / Q000302:isolation & purification; D010966:Plasmodium vivax / Q000302:isolation & purification; D012008:Recurrence; D012128:Respiratory Distress Syndrome / Q000175:diagnosis / Q000188:drug therapy / Q000469:parasitology*; D013163:Splenomegaly / Q000175:diagnosis / Q000188:drug therapy / Q000469:parasitology*
chemical_list: D000962:Antimalarials