Developmental gene expression of gastrin receptor in rat stomach.
Gastrin, which is present in fetal plasma, may have important roles in the development of gastric mucosa, since it is not only a potent stimulator of gastric acid secretion but also a growth promoting factor. Gastrin regulates various cellular functions via its receptors on cell membrane. Therefore, in order to elucidate a role for gastrin in the development of gastrointestinal system during gestation, Northern blot analysis was performed. The results of the study suggested that gastrin receptor is mainly present on parietal cells. Furthermore, proton pump and gastrin receptor gene expressions in parietal cells were strongly stimulated by the administration of exogenous gastrin. In conclusion, gastrin may be involved in the developmental change of parietal cells through its receptors.
Wang
H Y
HY
Department of Medicine, Kobe University School of Medicine, Japan.
Kinoshita
Y
Y
Hassan
M S
MS
Matsushima
Y
Y
Fukui
H
H
Maekawa
T
T
Okada
A
A
Waki
S
S
Kawanami
C
C
Kishi
K
K
Watanabe
M
M
Maeda
S
S
Chiba
T
T
D000818:Animals; D000831:Animals, Newborn; D015152:Blotting, Northern; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism*; D005755:Gastrins / Q000235:genetics / Q000494:pharmacology; D018507:Gene Expression Regulation, Developmental / Q000187:drug effects; D012333:RNA, Messenger / Q000032:analysis; D051381:Rats; D017207:Rats, Sprague-Dawley; D011949:Receptors, Cholecystokinin / Q000096:biosynthesis* / Q000187:drug effects / Q000235:genetics*; D013270:Stomach / Q000254:growth & development
D005755:Gastrins; D012333:RNA, Messenger; D011949:Receptors, Cholecystokinin