[Identification physico-chemical properties and immunochemical characteristic of prostate specific antigen and its complexes with protease inhibitors].
The study of the PSA complexes with the protease inhibitors has confirmed the opinion of possible existence the complexes of the PSA with a2-macroglobulins and a1-antihymotripsines in blood serum. The immunoenzyme analysis of the PSA and its complexes has made it possible to establish the normal level of the PSA corresponding complexes in donors blood serum. There are reasons to suppose, that the quantitative analysis of the PSA and its complexes with the protease inhibitors can be used for the early diagnosis of PC and its differential diagnosis with the prostate benign hyperplasia. In our opinion, the effect of the complex approach can be more informative than the ordinary PSA detection.
Chekhonin
V P
VP
Russian State Medical University, Laboratory of Immunochemistry, Serbsky National Research Center for Social and Forensic Psychiatry, Moscow.
Mazo
E B
EB
Riabukhin
I A
IA
Grigor'ev
M E
ME
D000818:Animals; D014408:Biomarkers, Tumor / Q000032:analysis; D002682:Chinchilla; D003937:Diagnosis, Differential; D007122:Immunoelectrophoresis; D008297:Male; D017430:Prostate-Specific Antigen / Q000276:immunology; D011470:Prostatic Hyperplasia / Q000097:blood / Q000175:diagnosis; D011471:Prostatic Neoplasms / Q000097:blood / Q000175:diagnosis; D011480:Protease Inhibitors / Q000276:immunology*; D011817:Rabbits; D012680:Sensitivity and Specificity; D000515:alpha 1-Antitrypsin / Q000276:immunology; D000511:alpha-Macroglobulins / Q000276:immunology
D014408:Biomarkers, Tumor; D011480:Protease Inhibitors; D000515:alpha 1-Antitrypsin; D000511:alpha-Macroglobulins; D017430:Prostate-Specific Antigen