Cerebral dysfunction after coronary artery bypass grafting done with mild or moderate hypothermia.
OBJECTIVE
Ninety-nine patients undergoing elective coronary artery bypass grafting were enrolled in a prospective, randomized study to evaluate the incidence of cerebral dysfunction after "mild" or "moderate" hypothermia during cardiopulmonary bypass.


METHODS
Patients were evaluated before and after operation before hospital discharge and in some cases at follow-up at least 6 weeks later with a complete neurologic examination (85 patients) and a battery of standard neuropsychometric tests (86 patients).


RESULTS
Postoperative changes detected by neurologic examination consisted of the appearance of new primitive reflexes in both groups. No statistically significant differences in incidence were found. The neuropsychometric performances of the two groups were statistically similar by either event-rate or group-rate analysis.


CONCLUSIONS
There is no detectable difference in postoperative cerebral dysfunction in patients undergoing coronary artery bypass grafting who are supported by cardiopulmonary bypass with either mild or moderate hypothermia.
Heyer
E J
EJ
Department of Anesthesiology, Columbia University, New York, NY 10032-3784, USA.
Adams
D C
DC
Delphin
E
E
McMahon
D J
DJ
Steneck
S D
SD
Oz
M C
MC
Michler
R E
RE
Rose
E A
EA
D000368:Aged; D002315:Cardiopulmonary Bypass; D003072:Cognition Disorders / Q000175:diagnosis / Q000209:etiology*; D001026:Coronary Artery Bypass / Q000379:methods*; D005260:Female; D006801:Humans; D007036:Hypothermia, Induced / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009460:Neurologic Examination; D009483:Neuropsychological Tests; D011446:Prospective Studies; D018709:Statistics, Nonparametric