title: An ulcerated lesion at the BCG vaccination site during the course of Kawasaki disease.
abstract: We describe a bacillus Calmette-Guérin (BCG) granuloma that occurred during the course of Kawasaki disease. A 12-month-old male infant with Kawasaki disease had an erythematous indurated plaque with prominent necrotic ulceration at the BCG vaccination site on the left upper arm. Histologic study showed a granulomatous reaction consisting of epithelioid histiocytes, lymphoid cells, and Langhans-type giant cells. No evidence of mycobacterial infection was obtained. The lesion healed completely within 2 weeks without administration of antituberculous agents. We believe that the granulomatous reaction occurred as a result of hypersensitivity to proteins in the BCG vaccine, which appeared after the onset of Kawasaki disease.
authors.affiliation: Department of Dermatology, Juso Municipal Hospital, Osaka, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Kuniyuki
authors.forename: M
authors.initials: M
authors.lastname: Asada
mesh_terms: D000276:Adjuvants, Immunologic / Q000009:adverse effects*; D001132:Arm; D001500:BCG Vaccine / Q000009:adverse effects*; D001706:Biopsy; D006099:Granuloma / Q000139:chemically induced* / Q000473:pathology; D006801:Humans; D007223:Infant; D008297:Male; D009080:Mucocutaneous Lymph Node Syndrome / Q000150:complications* / Q000473:pathology; D009336:Necrosis; D012867:Skin / Q000473:pathology; D012883:Skin Ulcer / Q000139:chemically induced* / Q000473:pathology
chemical_list: D000276:Adjuvants, Immunologic; D001500:BCG Vaccine