[Pernicious anemia and risk of cancer in Denmark].
The cancer pattern was investigated among 5072 patients with a discharge diagnosis of pernicious anaemia during 1977-1989, using data from the Danish Hospital Discharge, Central Population and Cancer registries. During 1-15 years of follow-up we found, in line with earlier reports, two to three-fold increases in the risk of cancer of the stomach, buccal cavity and pharynx, which were unchanged when the analysis was stratified according to sex and duration of follow-up. A previously reported positive association with haematological cancers could only be found for short term follow-up to indicate that no real association exists. Our cohort of patients with pernicious anaemia experienced significantly reduced risks of cervix and non-melanoma skin cancer.
Mellemkjoer
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L
Sektor for kraeftepidemiologi, Kraeftens Bekaempelse, København.
Gridley
G
G
Møller
H
H
Hsing
A W
AW
Linet
M S
MS
Brinton
L A
LA
Olsen
J H
JH
D000368:Aged; D000752:Anemia, Pernicious / Q000150:complications* / Q000453:epidemiology; D003718:Denmark / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000209:etiology*; D012042:Registries; D012307:Risk Factors