title: Risk of initiating antiarrhythmic drug therapy for atrial fibrillation in patients admitted to a university hospital.
abstract: BACKGROUND
  The risks of antiarrhythmic therapy are increasingly recognized, but the risks associated with the initiation of antiarrhythmic therapy in patients hospitalized for atrial fibrillation are poorly defined.
  
  
  OBJECTIVE
  To determine the incidence, time course, and predictors of adverse cardiac events that require intervention during initiation of antiarrhythmic drug therapy for atrial fibrillation.
  
  
  METHODS
  Retrospective chart review.
  
  
  METHODS
  University hospital.
  
  
  METHODS
  417 consecutive patients who underwent a total of 597 drug trials during a total of 550 hospitalizations for atrial fibrillation.
  
  
  METHODS
  Initiation of therapy with antiarrhythmic drugs: procainamide (189 trials), quinidine (179 trials), disopyramide (20 trials), propafenone (110 trials), flecainide (2 trials), sotalol (72 trials), and amiodarone (25 trials). Electrical conversion was performed during 247 trials.
  
  
  METHODS
  Incidence of adverse events and daily hazard rate were measured. Logistic regression was done to identify risk factors.
  
  
  RESULTS
  During the 597 drug trials, 80 (13.4%) cardiac adverse events occurred in 73 patients. The risk was greatest during the first 24 hours of therapy. Bradyarrhythmias were the most common adverse event, occurring in 47 trials (7.9%); prolongation of the QT interval warranting discontinuation of drug therapy (9 trials; 1.5%) and ventricular arrhythmias (8 trials; 1.3%) were less frequent. In multivariate analysis, previous myocardial infarction was associated with increased risk (odds ratio, 1.90 [95% CI, 1.05 to 3.43]) and the association between older age and increased risk (odds ratio, 1.29 per decade [CI, 0.97 to 1.72]) was of borderline statistical significance.
  
  
  CONCLUSIONS
  A significant risk for cardiac adverse events exists during initiation of antiarrhythmic therapy in patients hospitalized for atrial fibrillation. Observation with electrocardiographic monitoring seems advisable for 24 to 48 hours during initiation of antiarrhythmic therapy, particularly for elderly patients and patients who have previously had myocardial infarction.
authors.affiliation: Brigham and Women's Hospital, Boston, Massachusetts, USA.
authors.forename: W H
authors.initials: WH
authors.lastname: Maisel
authors.forename: K M
authors.initials: KM
authors.lastname: Kuntz
authors.forename: S C
authors.initials: SC
authors.lastname: Reimold
authors.forename: T H
authors.initials: TH
authors.lastname: Lee
authors.forename: E M
authors.initials: EM
authors.lastname: Antman
authors.forename: P L
authors.initials: PL
authors.lastname: Friedman
authors.forename: W G
authors.initials: WG
authors.lastname: Stevenson
mesh_terms: D000328:Adult; D000368:Aged; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D001281:Atrial Fibrillation / Q000188:drug therapy*; D004554:Electric Countershock; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008499:Medical Records; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D012189:Retrospective Studies; D012306:Risk; D012307:Risk Factors
chemical_list: D000889:Anti-Arrhythmia Agents