Antiphospholipid antibodies, infertility and recurrent miscarriage.
Antiphospholipid antibodies are found in 15% of women with recurrent miscarriage. These women have only a 10% live birth rate in subsequent pregnancies in which no pharmacological treatment is given. Pregnancy loss is often attributable to uteroplacental insufficiency subsequent to placental thrombosis. Treatment with low dose aspirin improves the live birth rate amongst women with antiphospholipid antibodies to 40% but this is further and significantly increased to 70% when they are treated with aspirin together with low-dose heparin.
Rai
R
R
Department of Obstetrics and Gynaecology, Imperial College School of Medicine at St Mary's, London, UK.
Regan
L
L
D000026:Abortion, Habitual / Q000209:etiology*; D000328:Adult; D000925:Anticoagulants / Q000627:therapeutic use; D016736:Antiphospholipid Syndrome / Q000150:complications* / Q000188:drug therapy; D001241:Aspirin / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D007247:Infertility, Female / Q000209:etiology*; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use; D011247:Pregnancy; D011256:Pregnancy Outcome
D000925:Anticoagulants; D010975:Platelet Aggregation Inhibitors; D006493:Heparin; D001241:Aspirin