[Dopaminergic system and neuronal death].
The mechanism involved in dopaminergic neuronal death remains unknown. Increased oxidative stress, inhibition of mitochondrial respiratory chain and apoptosis have been suggested as possible factors mediating cellular death. This article reviews the most important findings reported in parkinsonian brains related to nigral neuronal death.
Luquin
M R
MR
Departamento de Neurología y Neurocirugía, Clínica Universitaria de Navarra, Facultad de Medicina, Pamplona, España.
Saldise
L
L
D000818:Animals; D017209:Apoptosis; D001921:Brain / Q000473:pathology; D004298:Dopamine / Q000502:physiology*; D004579:Electron Transport; D008928:Mitochondria / Q000473:pathology; D009474:Neurons; D018384:Oxidative Stress; D051381:Rats; D013378:Substantia Nigra; D013482:Superoxide Dismutase / Q000648:ultrastructure
D013482:Superoxide Dismutase; D004298:Dopamine