The heterogeneous expression of CD80, CD86 and other adhesion molecules on leukemia and lymphoma cells and their induction by interferon.
CD80 (B7/BB-1, B7-1) and CD86 (B70, B7-2) take an important role in the interaction between T lymphocytes and antigen presenting cells (APCs) as co-stimulatory molecules. We analyzed the manifestation of adhesion molecules, including CD80 and CD86, on some leukemia and lymphoma cells. Constitutive expression of CD80 and/or CD86 was frequently observed on B cell leukemia/lymphoma cells, while it is rare on myeloid leukemia cells. Interferon-alpha (IFN-alpha) amplified the manifestation of MHC class I and interferon-gamma (IFN-gamma) did both class I and class II. We also showed CD80 could be induced by IFN-alpha on K562 cells, which were originally negative for CD80. Our data implies the immunotherapy via CD80 and CD86 for patients with hematological malignancies and the possibility to enhance it using interferons.
Tsukada
N
N
First Dept. of Internal Medicine, Niigata University School of Medicine, Japan. tsukada@med.niigata-u.ac.jp
Aoki
S
S
Maruyama
S
S
Kishi
K
K
Takahashi
M
M
Aizawa
Y
Y
D015703:Antigens, CD / Q000096:biosynthesis*; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001402:B-Lymphocytes / Q000378:metabolism; D018122:B7-1 Antigen / Q000096:biosynthesis*; D051940:B7-2 Antigen; D015815:Cell Adhesion Molecules / Q000096:biosynthesis* / Q000097:blood; D015395:Histocompatibility Antigens Class I / Q000096:biosynthesis; D000949:Histocompatibility Antigens Class II / Q000096:biosynthesis; D006801:Humans; D007370:Interferon Type I / Q000494:pharmacology*; D007371:Interferon-gamma / Q000494:pharmacology*; D007938:Leukemia / Q000378:metabolism*; D015448:Leukemia, B-Cell / Q000378:metabolism; D015479:Leukemia, Myelomonocytic, Acute / Q000378:metabolism; D007962:Leukocytes / Q000378:metabolism; D008223:Lymphoma / Q000378:metabolism*; D016393:Lymphoma, B-Cell / Q000378:metabolism; D008562:Membrane Glycoproteins / Q000096:biosynthesis*; D011994:Recombinant Proteins; D014407:Tumor Cells, Cultured / Q000187:drug effects
D015703:Antigens, CD; D000970:Antineoplastic Agents; D018122:B7-1 Antigen; D051940:B7-2 Antigen; C497964:CD86 protein, human; D015815:Cell Adhesion Molecules; D015395:Histocompatibility Antigens Class I; D000949:Histocompatibility Antigens Class II; D007370:Interferon Type I; D008562:Membrane Glycoproteins; D011994:Recombinant Proteins; D007371:Interferon-gamma