Increased plasma levels of soluble CD23 in haemorrhagic fever with renal syndrome; relation to virus-specific IgE.
In 15 consecutive patients hospitalized with nephropathia epidemica, a European form of haemorrhagic fever with renal syndrome (HFRS) caused by Puumala virus, plasma concentrations of soluble CD23 (sCD23) and Puumala virus-specific IgE were determined. In the acute phase of illness, 11/15 patients had increased sCD23 levels (> 91 U/ml), whereas in convalescence, values of 8/10 patients were normalized. Maximal sCD23 values were correlated to maximal concentrations of Puumala virus-specific serum IgE (r = 0.597; P = 0.025). The results are compatible with a known ability of sCD23 to augment IgE production.
Alexeyev
O A
OA
Department of Virology, Umeå University, Sweden.
Linderholm
M
M
Elgh
F
F
Wadell
G
G
Juto
P
P
Tärnvik
A
A
D000328:Adult; D000368:Aged; D000914:Antibodies, Viral / Q000378:metabolism*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006476:Orthohantavirus / Q000276:immunology*; D006480:Hemorrhagic Fever with Renal Syndrome / Q000097:blood* / Q000503:physiopathology / Q000821:virology; D006801:Humans; D007073:Immunoglobulin E / Q000378:metabolism*; D018793:Interleukin-13 / Q000097:blood; D007668:Kidney / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D017455:Receptors, IgE / Q000097:blood*
D000914:Antibodies, Viral; D018793:Interleukin-13; D017455:Receptors, IgE; D007073:Immunoglobulin E