Touring the landscapes: partially folded proteins examined by hydrogen exchange.
Recent studies on Escherichia coli ribonuclease H and several other proteins reveal a specific region in each protein that remains structured in partially folded conformations. These regions play a dominant role in determining the fold and stability of the protein.
Chamberlain
A K
AK
Department of Molecular and Cell Biology, University of California Berkeley 94720, USA.
Marqusee
S
S
D006859:Hydrogen / Q000737:chemistry / Q000378:metabolism*; D008956:Models, Chemical; D017510:Protein Folding; D011506:Proteins / Q000737:chemistry*; D016914:Ribonuclease H / Q000737:chemistry*
D011506:Proteins; D006859:Hydrogen; D016914:Ribonuclease H