Persistence of human leukocyte antigen (HLA) antibodies after one year in children receiving cryopreserved valved allografts.
This study shows that the broad anti-HLA antibody response against cryopreserved valved allografts used for surgical repair of congenital heart disease persists beyond 1 year after implantation. In 3 patients, there were clearly defined HLA antibody specificities consistent with the HLA phenotypes of the patients, i.e., the panel-reactive antibody was directed against major alloantigen groups that were not expressed by the antibody responders.
Shaddy
R E
RE
Department of Pediatrics, University of Utah School of Medicine and Primary Childrens Medical Center, Salt Lake City 84113, USA.
Thompson
D D
DD
Osborne
K A
KA
Hawkins
J A
JA
Fuller
T C
TC
D000293:Adolescent; D001021:Aortic Valve / Q000637:transplantation*; D002648:Child; D002675:Child, Preschool; D015925:Cryopreservation; D000939:Epitopes; D006330:Heart Defects, Congenital / Q000601:surgery*; D015395:Histocompatibility Antigens Class I / Q000276:immunology*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007518:Isoantibodies / Q000097:blood*; D011446:Prospective Studies; D011664:Pulmonary Valve / Q000637:transplantation*; D013997:Time Factors; D014184:Transplantation, Homologous
D000939:Epitopes; D015395:Histocompatibility Antigens Class I; D007518:Isoantibodies