COPII and secretory cargo capture into transport vesicles.
Yeast cylosolic coat proteins (COPII) direct the formation of vesicles from the endoplasmic reticulum. The vesicles selectively capture both cargo molecules and the secretory machinery that is necessary for the fusion of the vesicle with the recipient compartment, the Golgi apparatus. Recent efforts have aimed to understand how proteins are selected for inclusion into these vesicles. A variety of cargo adaptors may concentrate and sort secretory and membrane proteins by direct or indirect interaction with a subset of coat protein subunits.
Kuehn
M J
MJ
Department of Molecular and Cell Biology, Howard Hughes Medical Institute, University of California, Berkeley 94720, USA. Kuehn@mendel.berketey.edu
Schekman
R
R
D018699:Coated Vesicles / Q000502:physiology*; D004721:Endoplasmic Reticulum / Q000502:physiology; D005656:Fungal Proteins / Q000502:physiology*; D006056:Golgi Apparatus / Q000502:physiology; D007425:Intracellular Membranes / Q000502:physiology*; D008561:Membrane Fusion; D008954:Models, Biological; D012441:Saccharomyces cerevisiae / Q000502:physiology* / Q000648:ultrastructure; D015398:Signal Transduction
D005656:Fungal Proteins