[The protective effects of dichloroacetate on cerebral ischemia after reperfusion of fed rats].
OBJECTIVE
To study the brain protective mechanisms of dichloroacetate (DCA) by observing the influence of DCA on the biochemical and pathological changes in ischemic brain tissues in different periods of reperfusion.


METHODS
The FED-RAT cerebral ischemic model induced by 4-vessel occlusion was applied. 55 mature male Sprague-Dawley rats were divided into the control group, normal saline and DCA-treated groups before ischemia, normal saline and DCA-treated groups after ischemia equally and randomly.


RESULTS
DCA could significantly lower the brain lactic acid, water content, and the diameter of cortical neurons, and protect the pathological damage of the membranaceous structure, before or after ischemia at a dose of 25 mg/kg, compared with the normal saline treated groups.


CONCLUSIONS
Lowering brain lactate, resisting brain edema and protecting the membranaceous structures are the main brain protective mechanisms of DCA in biochemistry and ultrastructure.
Peng
J
J
Department of Neurology, Second Affiliated Hospital, Hubei Medical University, Wuhan.
Huang
H
H
Wang
F
F
D000818:Animals; D002545:Brain Ischemia / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D003999:Dichloroacetic Acid / Q000494:pharmacology*; D019344:Lactic Acid / Q000378:metabolism; D008297:Male; D018696:Neuroprotective Agents / Q000494:pharmacology*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D015427:Reperfusion Injury / Q000517:prevention & control*
D018696:Neuroprotective Agents; D019344:Lactic Acid; D003999:Dichloroacetic Acid