Colocalization of GABA(A) and NMDA receptors within the dorsal motor nucleus of the vagus nerve (DMV) of the rat.
Changes in gastric motor activity are observed in response to glutamate and GABA in the DMV. We investigated the expression of GABA(A) and NMDA receptors within DMV neurons projecting to the stomach using pseudorabies virus (PRV). PRV immunoreactive (PRV-IR) cells expressing GABA(A) alpha1-IR, also expressed NMDAR1 suggesting that NMDA and GABA(A) receptors are colocalized. These results provide a neuroanatomical basis for these receptors jointly playing a role in gastric motor functions.
Broussard
D L
DL
Division of Gastroenterology and Nutrition, The Children's Hospital of Philadelphia, PA 19104, USA.
Li
H
H
Altschuler
S M
SM
D000818:Animals; D008297:Male; D018613:Microscopy, Confocal; D009046:Motor Neurons / Q000378:metabolism* / Q000648:ultrastructure; D051381:Rats; D017207:Rats, Sprague-Dawley; D011963:Receptors, GABA-A / Q000378:metabolism*; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism*; D013270:Stomach / Q000502:physiology; D014630:Vagus Nerve / Q000378:metabolism*
D011963:Receptors, GABA-A; D016194:Receptors, N-Methyl-D-Aspartate