Hereditary colon cancer.
Hereditary colon cancer comprises approximately 10% of total colon cancer, a disease that affects 6% of the North American population. Knowledge of molecular genetics of familial adenomatous polyposis and hereditary nonpolyposis colon cancer has improved our diagnostic abilities and management, as well as furthered our understanding of the mechanisms of tumour initiation and progression.
Gilchrist
D M
DM
Department of Medicine, University of Alberta, Edmonton. gilchri@uah.ualberta.ca
D011125:Adenomatous Polyposis Coli / Q000175:diagnosis / Q000235:genetics; D003110:Colonic Neoplasms / Q000235:genetics*; D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000175:diagnosis / Q000235:genetics; D006801:Humans