[Subacute combined degeneration of the spinal cord: manifestations of esophageal epidermoid carcinoma].
BACKGROUND
Subacute combined degeneration of the spinal cord associated with vitamin B12 deficit is well known. However a paraneoplastic induced cyanocobalamin malabsorption responsible for either subacute combined degeneration of the spinal cord, has not been reported. Moreover, the possibility of either subacute combined degeneration of the spinal cord may be manifestation of a cancer, it's unknown.


METHODS
We present the case of a 73-year-old woman with cutaneous paleness and clinical manifestations of a subacute combined degeneration of the spinal cord. Laboratory analysis showed a megaloblastic anemia and Schilling test showed cyanocobalamin malabsorption corrected by intrinsic factor. Anti-intrinsic factor antibodies were positive. Chronic atrophic gastritis and immunological diseases associated with pernicious anemia or with anti-intrinsic factor positive, were excluded. A hidden esophageal squamous cell carcinoma was discovered. Necropsy confirmed both, subacute combined degeneration of the spinal cord and esophageal carcinoma in the absence of chronic atrophic gastritis.


CONCLUSIONS
Anti-intrinsic factor antibodies were the only found factor which could explain cyanocobalamin malabsorption. A esophageal squamous cel carcinoma was discovered. In our case, vitamin B12 malabsorption had a paraneoplastic origin mediated by anti-intrinsic factor antibodies. Subacute combined degeneration of the spinal cord may be the manifestation of a hidden esophageal squamous cell carcinoma.
Madrid
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A
Servicios de Neurología, Hospital Universitario Virgen del Rocío, Sevilla.
Casado
J L
JL
Pérez-Errazquin
F
F
Vázquez
A
A
Garzón
F
F
Gil-Peralta
A
A
D000368:Aged; D000749:Anemia, Megaloblastic; D000752:Anemia, Pernicious; D002294:Carcinoma, Squamous Cell / Q000150:complications* / Q000648:ultrastructure*; D004938:Esophageal Neoplasms / Q000150:complications* / Q000648:ultrastructure*; D004947:Esophagus / Q000648:ultrastructure*; D017809:Fatal Outcome; D006801:Humans; D013118:Spinal Cord Diseases / Q000209:etiology* / Q000473:pathology*