Chemotherapy: the more the better? Overview.
Although numerous clinical trials of high-dose chemotherapy have been performed, few have demonstrated that such strategies are statistically significantly better than other forms of therapy. Application of dose-intensive and/or high-dose chemotherapy should be limited to drug-sensitive tumors, with primary end points being increased cure rates or prolonged survival. This should be confirmed by randomized clinical trials comparing dose-intensive and/or high-dose chemotherapy with standard therapeutic modalities.
Saijo
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Pharmacology Division, National Cancer Center Research Institute, Tokyo, Japan.
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D019008:Drug Resistance, Neoplasm; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D016032:Randomized Controlled Trials as Topic; D016019:Survival Analysis; D016896:Treatment Outcome