[Coexpression of CD4 and CD8 antigens and the appearance of HLA-DR and CD25 receptors on lymphocytes as markers of immune activation in patients with HIV infection].
Results of quantitative determinations of peripheral blood lymphocytes presenting CD4 or simultaneously CD4 and CD8 antigens as well as HLA-DR and CD25 antigens in patients with different clinical stages of CD4+ and CD4+CD8+ cells were observed. The fall of CD4+CD8+ lymphocytes percentage was slight in the initial stages of infection but more sharp during the full-blown AIDS. The percentage of HLA-DR positive cells was higher in seropositive patients in comparison with controls and increased with the progression of HIV infection into AIDS. The CD25 expression was also higher in HIV-infected patients, however, it decreased in patients with late stages of AIDS. The observed disturbances could be caused by the direct destruction by replicating HIV or by severe abnormalities of immune system function.
Radkowski
M
M
Zakładu Immunopatologii Instytutu Chorób Zakaźnych i Pasozytniczych Akademii Medycznej w Warszawie.
Sadowska
M
M
Kopicz-Kamińska
E
E
Horban
A
A
Slusarczyk
J
J
D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology; D000328:Adult; D015415:Biomarkers / Q000032:analysis; D016516:CD4-CD8 Ratio; D005260:Female; D015658:HIV Infections / Q000276:immunology*; D006684:HLA-DR Antigens / Q000032:analysis*; D006801:Humans; D008213:Lymphocyte Activation; D008297:Male; D008875:Middle Aged; D015375:Receptors, Interleukin-2 / Q000032:analysis*; D013601:T-Lymphocytes / Q000276:immunology*
D015415:Biomarkers; D006684:HLA-DR Antigens; D015375:Receptors, Interleukin-2