title: Pyrethroid decrease in central nervous system from nerve agent pretreatment.
abstract: We studied the effect of pyridostigmine bromide, a nerve agent prophylactic, on the central nervous system (CNS) uptake of [14C]permethrin, a pyrethroid insecticide, at scaled human-equivalent exposures in rats using accelerator mass spectrometry (AMS). AMS detects 14C at attomole sensitivities and determines the tissue distribution of 14C-labeled compounds. Pyridostigmine bromide in chow at 7.75 mg kg(-1) per day lowered the CNS tissue levels of permethrin, dosed at 4.75 microg kg(-1), in the CNS of rats by 30%. These results are inconsistent with hypothesized synergy of such compounds as a precursor to 'Gulf War syndrome'.
authors.affiliation: Lawrence Livermore National Laboratory, CA 94551, USA.
authors.forename: B A
authors.initials: BA
authors.lastname: Buchholz
authors.forename: N H
authors.initials: NH
authors.lastname: Pawley
authors.forename: J S
authors.initials: JS
authors.lastname: Vogel
authors.forename: R J
authors.initials: RJ
authors.lastname: Mauthe
mesh_terms: D000818:Animals; D002250:Carbon Radioisotopes; D002490:Central Nervous System / Q000378:metabolism*; D002800:Cholinesterase Inhibitors / Q000494:pharmacology*; D007306:Insecticides / Q000493:pharmacokinetics*; D008297:Male; D026023:Permethrin; D011722:Pyrethrins / Q000493:pharmacokinetics*; D011729:Pyridostigmine Bromide / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014018:Tissue Distribution
chemical_list: D002250:Carbon Radioisotopes; D002800:Cholinesterase Inhibitors; D007306:Insecticides; D011722:Pyrethrins; D026023:Permethrin; D011729:Pyridostigmine Bromide