NGF antibodies impair long-term depression at the mossy fibre-CA3 synapse in the developing hippocampus.
Nerve growth factor (NGF) and other neurotrophins are proteins involved in neuronal survival and differentiation. Much experimental evidence is now drawing attention into a role of neurotrophins in activity-dependent synaptic plasticity processes. We now show that slices from rats chronically deprived of NGF, by intraventricular injection of alpha D11 hybridoma cells, which produce monoclonal antibodies against NGF, display a reduced probability of induction of long-term depression at the mossy fibre-CA3 synapse.
Ruberti
F
F
Neuroscience Program, International School for Advanced Studies (SISSA), Trieste, Italy. ruberti@icgeb.trieste.it
Berretta
N
N
Cattaneo
A
A
Cherubini
E
E
D000818:Animals; D000911:Antibodies, Monoclonal / Q000096:biosynthesis / Q000502:physiology; D017690:Cell Transplantation / Q000502:physiology; D005071:Evoked Potentials / Q000187:drug effects; D006624:Hippocampus / Q000166:cytology / Q000187:drug effects*; D006825:Hybridomas / Q000276:immunology / Q000378:metabolism; D066298:In Vitro Techniques; D009101:Multiple Myeloma / Q000276:immunology; D009368:Neoplasm Transplantation / Q000502:physiology; D009412:Nerve Fibers / Q000187:drug effects*; D009414:Nerve Growth Factors / Q000276:immunology / Q000502:physiology*; D009473:Neuronal Plasticity / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D013569:Synapses / Q000187:drug effects*
D000911:Antibodies, Monoclonal; D009414:Nerve Growth Factors