title: Improved diagnostic accuracy of planar imaging with technetium 99m-labeled tetrofosmin compared with thallium-201 for the detection of coronary artery disease.
abstract: BACKGROUND
  Receiver operating characteristic (ROC) curve analysis provides detailed information about the performance of a diagnostic test.
  
  
  RESULTS
  As part of a multicenter phase III trial, 160 patients with known or suspected coronary artery disease underwent planar stress-rest 99mTc-labeled tetrofosmin and stress-redistribution 201Tl imaging within 14 days of each other, to compare the diagnostic accuracy of these imaging modalities by ROC curve analysis. Coronary arteriography was used as the reference standard and greater than 70% stenosis was considered significant. ROC curve analysis showed improved detection of coronary artery disease with 99mTc-labeled tetrofosmin compared with 201Tl, with ROC curve areas of 0.765 versus 0.644, respectively (p = 0.02). 99mTc-labeled tetrofosmin also better identified single-vessel disease in those without previous myocardial infarction (ROC curve areas of 0.684 vs 0.510 for 99mTc-labeled tetrofosmin and 201Tl, respectively; p = 0.04) and enhanced the detection of multivessel disease in those with previous myocardial infarction (ROC curve areas of 0.764 vs 0.638, respectively; p = 0.02).
  
  
  CONCLUSIONS
  Detailed assessment of diagnostic performance by ROC curve analysis shows that, for planar imaging, 99mTc-labeled tetrofosmin enhances the detection of coronary artery disease compared with 201Tl.
authors.affiliation: Department of Cardiac Research, Northwick Park Hospital, Harrow, United Kingdom.
authors.forename: R S
authors.initials: RS
authors.lastname: Khattar
authors.forename: R C
authors.initials: RC
authors.lastname: Hendel
authors.forename: J C
authors.initials: JC
authors.lastname: Crawley
authors.forename: F J
authors.initials: FJ
authors.lastname: Wackers
authors.forename: P
authors.initials: P
authors.lastname: Rigo
authors.forename: B L
authors.initials: BL
authors.lastname: Zaret
authors.forename: B S
authors.initials: BS
authors.lastname: Sridhara
authors.forename: A
authors.initials: A
authors.lastname: Lahiri
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003327:Coronary Disease / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009943:Organophosphorus Compounds; D015609:Organotechnetium Compounds; D011877:Radionuclide Imaging; D013794:Thallium Radioisotopes
chemical_list: D009943:Organophosphorus Compounds; D015609:Organotechnetium Compounds; D013794:Thallium Radioisotopes; C078700:technetium tc-99m tetrofosmin