[Age dependence of cerebral Tc-99m-ECD distribution between preschool and school-age children and adults].
OBJECTIVE
This present study deals with the question whether normal distribution of local cerebral blood flow (ICBF) agents in adults can be transferred to the age group of 4 to 15 years old children.


METHODS
23 children (age: 4-15 years, mean 11 +/- 3 y) (group I) and 10 adults (age: 27-56 years, mean 45 +/- 10 y) (group II) without evidence of cerebrovascular disease or other brain diseases underwent Tc-99m-ECD-SPECT imaging. Counts in the cortical ROIs were related to those of cerebellar ROIs (= 100%).


RESULTS
In group I, relative cortical activity exceeded that of group II, particularly in parietal (107.6 +/- 9.8 vs. 84.1 +/- 12.4%), frontal (97.7 +/- 6.7 vs. 79.4 +/- 8.9%), left temporal areas (99.7 +/- 7.4 vs. 84.9 +/- 10.1%) and in the singular cortex (112.1 +/- 9.1 vs. 95.9 +/- 10.1%, p < 0.05). Cerebral activity uptake/injected dose/acquisition period was linearly correlated with age in group I (r = -0.78, p < 0.001). There was also a correlation of the relative local count density with age in 5 parietal ROIs (r = -0.42 to -0.57), in 2 frontal ROIs (r = -0.48), in 7 temporal ROIs (r = -0.42 to -0.58) and in 2 occipital ROIs (r = -0.44). In 14 cortical regions relative counts differed when subgroups of children aged 4-10 and 11-15 years were analysed.


CONCLUSIONS
There are systematic differences between 4 to 15 years old children and adults regarding the normal distribution of ICBF. Diagnostic use of perfusion agents has to consider the respective age-adjusted normal flow maps; respective normal ranges should be determined for age groups of 4-10 and of 11-15 years separately.
Barthel
H
H
Klinik und Poliklinik für Nuklearmedizin, Universität Leipzig, Deutschland.
Wiener
M
M
Dannenberg
C
C
Sattler
B
B
Martin
W G
WG
Knapp
W H
WH
D000293:Adolescent; D000328:Adult; D000375:Aging / Q000502:physiology*; D001921:Brain / Q000098:blood supply* / Q000000981:diagnostic imaging* / Q000378:metabolism; D002560:Cerebrovascular Circulation; D002648:Child; D002675:Child, Preschool; D003545:Cysteine / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D004569:Electroencephalography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009928:Organ Specificity; D015609:Organotechnetium Compounds / Q000493:pharmacokinetics*; D019275:Radiopharmaceuticals; D012039:Regional Blood Flow; D012044:Regression Analysis; D015899:Tomography, Emission-Computed, Single-Photon
D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; C059659:technetium Tc 99m bicisate; D003545:Cysteine