title: Endothelin-1 induced lesions of the frontoparietal cortex of the rat. A possible model of focal cortical ischemia.
abstract: Endothelin-1 (ET-1) was unilaterally applied onto the surface of the dorsal frontoparietal cortex of the rat. Cortical blood flow measurements using laser-Doppler flowmetry demonstrated dose-dependent reductions of frontoparietal cortical blood flow. Histological analysis demonstrated dose-related lesions and the time course was followed using MRI. The lesions appear to be associated with a large penumbra area indicated by morphological characteristics. Thus, cortical surface exposure to ET-1 may produce graded lesions of the frontoparietal cortex related to local ischemia.
authors.affiliation: Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden.
authors.forename: K
authors.initials: K
authors.lastname: Fuxe
authors.forename: B
authors.initials: B
authors.lastname: Bjelke
authors.forename: B
authors.initials: B
authors.lastname: Andbjer
authors.forename: H
authors.initials: H
authors.lastname: Grahn
authors.forename: R
authors.initials: R
authors.lastname: Rimondini
authors.forename: L F
authors.initials: LF
authors.lastname: Agnati
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002540:Cerebral Cortex / Q000098:blood supply / Q000000981:diagnostic imaging / Q000473:pathology; D002560:Cerebrovascular Circulation / Q000187:drug effects; D004195:Disease Models, Animal; D019332:Endothelin-1 / Q000633:toxicity*; D005625:Frontal Lobe / Q000187:drug effects* / Q000473:pathology / Q000503:physiopathology; D002546:Ischemic Attack, Transient / Q000473:pathology / Q000503:physiopathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D010296:Parietal Lobe / Q000187:drug effects* / Q000473:pathology / Q000503:physiopathology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012039:Regional Blood Flow / Q000187:drug effects; D014463:Ultrasonography
chemical_list: D019332:Endothelin-1