The diversity of Rab proteins in vesicle transport.
Rab proteins have been primarily implicated in vesicle docking as regulators of SNARE pairing. Recent findings, however, indicate that their function in vesicle trafficking can go beyond this role, and a number of proteins, unrelated to each other, have been identified as putative Rab effectors. Although the GTPase switch of Rab proteins is highly conserved, functional mechanisms may be highly diversified among members of the Rab family.
Novick
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Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06520-8002, USA. petet_novick@quickmail.cia.yale.edu
Zerial
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M
D000595:Amino Acid Sequence; D000818:Animals; D002462:Cell Membrane / Q000502:physiology*; D018699:Coated Vesicles / Q000502:physiology*; D017124:Conserved Sequence; D004721:Endoplasmic Reticulum / Q000502:physiology*; D020558:GTP Phosphohydrolases / Q000737:chemistry / Q000378:metabolism; D019204:GTP-Binding Proteins / Q000737:chemistry / Q000502:physiology*; D006056:Golgi Apparatus / Q000502:physiology*; D006160:Guanosine Triphosphate / Q000378:metabolism; D007425:Intracellular Membranes / Q000502:physiology*; D008954:Models, Biological; D008969:Molecular Sequence Data; D017368:Protein Prenylation; D012441:Saccharomyces cerevisiae / Q000502:physiology
D006160:Guanosine Triphosphate; D020558:GTP Phosphohydrolases; D019204:GTP-Binding Proteins