Listeriolysin and IrpA are major protein targets of the human humoral response against Listeria monocytogenes.
We have examined the human humoral immune response directed against proteins of Listeria monocytogenes in both healthy individuals and listeriosis patients. Two major targets for an antibody response were found in individuals that did not suffer from listeriosis: listeriolysin (Hly) and the recently described internalin-related protein (IrpA). In contrast, the humoral response in listeriosis patients appears to be more heterogeneous and included Hly, IrpA, InlB, and ActA as major targets.
Grenningloh
R
R
National Research Center for Biotechnology, Department of Cell Biology and Immunology, Braunschweig, Germany. rgr@gbf-braunschweig.de
Darji
A
A
Wehland
J
J
Chakraborty
T
T
Weiss
S
S
D000907:Antibodies, Bacterial / Q000276:immunology*; D000942:Antigens, Bacterial / Q000276:immunology*; D001426:Bacterial Proteins / Q000276:immunology*; D001427:Bacterial Toxins; D015153:Blotting, Western; D006360:Heat-Shock Proteins / Q000276:immunology*; D006460:Hemolysin Proteins; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D008089:Listeria monocytogenes / Q000276:immunology*; D008088:Listeriosis / Q000276:immunology*; D008970:Molecular Weight
D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D001426:Bacterial Proteins; D001427:Bacterial Toxins; D006360:Heat-Shock Proteins; D006460:Hemolysin Proteins; D007074:Immunoglobulin G; C038705:hlyA protein, Listeria monocytogenes