Cytokine production during infection with Hymenolepis diminuta in BALB/c mice.
Levels of the cytokines IFN-gamma, IL-2, IL-3, IL-4 and IL-5 were monitored in cells from the mesenteric lymph nodes (MLN) of BALB/c mice infected with Hymenolepis diminuta after stimulation in vitro with Con-A. Infection was associated with an increased production of IL-3, IL-4 and IL-5 and a low production of IFN-gamma, indicating the preferential activation of a Th2 response. It is suggested that this reflects the purely lumenal development of this worm. The results are discussed in relation to effector mechanisms known to be involved in immunity to intestinal helminths.
Palmas
C
C
Istituto di Patologia Sperimentale, Università degli Studi di Cagliari, Italy.
Bortoletti
G
G
Gabriele
F
F
Wakelin
D
D
Conchedda
M
M
D000818:Animals; D005260:Female; D006925:Hymenolepiasis / Q000276:immunology* / Q000469:parasitology; D006926:Hymenolepis / Q000302:isolation & purification; D007371:Interferon-gamma / Q000096:biosynthesis*; D007376:Interleukin-2 / Q000096:biosynthesis; D007377:Interleukin-3 / Q000096:biosynthesis; D015847:Interleukin-4 / Q000096:biosynthesis; D015848:Interleukin-5 / Q000096:biosynthesis; D007378:Interleukins / Q000096:biosynthesis*; D008198:Lymph Nodes / Q000276:immunology; D008213:Lymphocyte Activation; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D013047:Specific Pathogen-Free Organisms; D018418:Th2 Cells / Q000276:immunology
D007376:Interleukin-2; D007377:Interleukin-3; D015848:Interleukin-5; D007378:Interleukins; D015847:Interleukin-4; D007371:Interferon-gamma