Impact of PUVA therapy on HIV viremia: a pilot study.
BACKGROUND
Treatment by ultraviolet radiation (UV) during human immunodeficiency virus (HIV) infection is controversial, since exposure of HIV-infected cells in vitro to UV enhances HIV replication in vitro.


METHODS
Four consecutive AIDS patients with psoriasis and CD4 count lower than 20/mm3 were treated with 8-methoxypsoralen and UVA (PUVA). HIV viremia expressed as long of HIV-1 RNA copies/ml of plasma was quantified 10 min before and 1 h following UVA exposure, every week during PUVA therapy and at the end of treatment. The Psoriasis Area Surface Index (PASI) score was used to quantify the severity of psoriasis.


RESULTS
No significant change in HIV-1 RNA level was observed in the 18 paired samples analyzed before and 1 h after PUVA (median: -0.05 log HIV-1 RNA, range: -0.50-0.21, p = 0.10). After 12-31 UVA exposure for a total dose of 15.5-196 J/cm2 over a period of 6-15 weeks, viremia changes from baseline in the 4 patients were -0.61, -0.07, 0.36 and 0.39 log HIV RNA. In 1 patient without antiviral treatment, a persistent decrease in viremia and transient increase in CD4 cell count were observed. PUVA was well tolerated and associated with significant improvement of the PASI score in 3 patients.


CONCLUSIONS
HIV viremia is not significantly modified by PUVA therapy in AIDS patients with psoriasis.
Pechère
M
M
University Hospitals of Geneva, Switzerland.
Yerly
S
S
Lemonnier
E
E
Krischer
J
J
Perrin
L
L
Saurat
J H
JH
D000163:Acquired Immunodeficiency Syndrome / Q000821:virology*; D019380:Anti-HIV Agents / Q000627:therapeutic use; D018791:CD4 Lymphocyte Count; D015497:HIV-1 / Q000235:genetics / Q000302:isolation & purification / Q000528:radiation effects; D006801:Humans; D008730:Methoxsalen / Q000627:therapeutic use; D011701:PUVA Therapy; D010865:Pilot Projects; D011565:Psoriasis / Q000188:drug therapy; D012367:RNA, Viral / Q000032:analysis; D011829:Radiation Dosage; D013997:Time Factors; D014466:Ultraviolet Rays; D014766:Viremia / Q000821:virology*; D014779:Virus Replication / Q000528:radiation effects
D019380:Anti-HIV Agents; D012367:RNA, Viral; D008730:Methoxsalen