title: Studies on the anti-inflammatory activity of rhizomes of Nelumbo nucifera.
abstract: The anti-inflammatory activity of the methanol extract of Nelumbo nucifera rhizome as well as of betulinic acid, a steroidal triterpenoid isolated from it, were evaluated on carrageenin and serotonin induced rat paw edema. Methanol extract at doses of 200 and 400 mg/kg and betulinic acid at doses of 50 mg/kg and 100 mg/kg p.o., showed significant anti-inflammatory activity in both the models of inflammation in rats. The effects produced were comparable to that of phenylbutazone and dexamethasone, two prototype anti-inflammatory drugs.
authors.forename: P K
authors.initials: PK
authors.lastname: Mukherjee
authors.forename: K
authors.initials: K
authors.lastname: Saha
authors.forename: J
authors.initials: J
authors.lastname: Das
authors.forename: M
authors.initials: M
authors.lastname: Pal
authors.forename: B P
authors.initials: BP
authors.lastname: Saha
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000494:pharmacology*; D004487:Edema / Q000473:pathology; D008297:Male; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal