[Blood pressure-regulating factor vasopressin].
The DNA of AVP vasopressin (AVP) is composed of 3 exons (A, B, C) and 2 introns (I, II). Following transcription, translation, and processing AVP(MW 1081) is produced. AVP receptors (VR) are classified into V1aR, V1bR and V2R. V1aR is composed of 418 amino acids (AA) and its MW is 46745. V1aR is in the vascular smooth muscle (VSM) and activates the phosphatidylinositol system, leading to the contraction of VSM. V1bR is composed of 424 AA and its MW 47034. It's second messenger systems are obscure, but V1bR is responsible for ACTH release. V2R is composed of 371 AA and its MW 40285. V2R is in the kidney and enhances the production of cAMP, leading to renal water and urea reabsorption.
Kimura
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Tohoku University School of Medicine 2nd Department of Internal Medicine.
D000324:Adrenocorticotropic Hormone / Q000378:metabolism; D000818:Animals; D001794:Blood Pressure / Q000502:physiology*; D001834:Body Water / Q000378:metabolism; D000242:Cyclic AMP / Q000378:metabolism; D006801:Humans; D006973:Hypertension / Q000209:etiology; D017483:Receptors, Vasopressin / Q000737:chemistry / Q000502:physiology; D015290:Second Messenger Systems; D015398:Signal Transduction; D014508:Urea / Q000378:metabolism; D014667:Vasopressins / Q000502:physiology*
D017483:Receptors, Vasopressin; D014667:Vasopressins; D014508:Urea; D000324:Adrenocorticotropic Hormone; D000242:Cyclic AMP