[Expression of thyrotropin receptor gene in autoimmune thyroid disease and the relation to expression of HLA genes].
OBJECTIVE
To investigate the expression of TSH receptor in autoimmune thyroid disease (AITD) and the relation to expression of HLA I and II genes.


METHODS
The TSH receptor transcript levels were examined in 10 human thyroid fragments by Northern blot analysis. Graves' disease 7, Hashimoto's disease 2, and 1 healthy thyroid gland.


RESULTS
TSH receptor transcript levels were higher in Graves' disease than in Hashimoto's disease and healthy control.


CONCLUSIONS
TSH receptor expression was inversely related to HLA I and II expression and lymphocyte infiltration.
Yang
D
D
Department of Endocrinology, First Teaching Hospital, Beijing Medical University.
Gao
Y
Y
Li
C
C
D015870:Gene Expression; D005805:Genes, MHC Class I; D005802:Genes, MHC Class II; D006111:Graves Disease / Q000235:genetics*; D006801:Humans; D012333:RNA, Messenger / Q000378:metabolism; D011989:Receptors, Thyrotropin / Q000235:genetics*; D013967:Thyroiditis, Autoimmune / Q000235:genetics*
D012333:RNA, Messenger; D011989:Receptors, Thyrotropin