title: The application of diffusion-weighted line-scanning for the rapid assessment of water ADC changes in stroke at high magnetic fields.
abstract: Rapid changes in the apparent diffusion coefficient of water following brain ischemia have been extensively studied using echo planar diffusion imaging at low fields (2.0 T). There is a desire to perform these studies at higher fields (> 3.0 T) where the benefits of improved signal-to-noise can be exploited. Unfortunately, EPI diffusion is technically difficult to implement at high fields because of large magnetic susceptibility effects. This article demonstrates the feasibility of employing a line-scan diffusion protocol for ADCw measurements in stroke. The technique was applied on a 4.0 T system to monitor the decline in ADCw following the induction of focal cerebral ischemia in rat. ADCw data were acquired every 15 s with 10 b-values or every 22.5 s with 15 b-values, with a cubic spatial resolution of 1.5 mm. The results demonstrate that estimates of ADCw can be acquired with coefficients of variation under 3.0%, and with a combination of spatial and temporal resolution comparable to that previously reported for EPI.
authors.affiliation: Center for Advanced Brain Imaging, Nathan S. Kline Institute, Orangeburg, NY 10962, USA.
authors.forename: M N
authors.initials: MN
authors.lastname: Yongbi
authors.forename: N C
authors.initials: NC
authors.lastname: Huang
authors.forename: C A
authors.initials: CA
authors.lastname: Branch
authors.forename: J A
authors.initials: JA
authors.lastname: Helpern
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D004058:Diffusion; D002546:Ischemic Attack, Transient / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D014867:Water / Q000032:analysis / Q000378:metabolism*
chemical_list: D014867:Water