Effect of photodynamic therapy on selected laboratory values of patients with nasopharyngeal carcinoma.
We determined pre- and post-photodynamic therapy (PDT) serum levels of soluble interleukin-2 receptor (SIL-2R) and interleukin-2 (IL-2), as well as activity of natural killer (NK) cells, among 24 patients with either persistent or recurrent nasopharyngeal carcinoma (NPC), using a double-antibody sandwich technique, tritiated thymidine-deoxyribonucleoside incorporation, and iodine 125-uridine-deoxyribonucleoside release techniques, respectively. The results showed that the post-PDT serum level of SIL-2R had significantly declined (p < .0005), while that of IL-2 and the NK cell activity had significantly increased (p < .0005), compared with pre-PDT values, suggesting an immunoenhancing effect of PDT on NPC patients.
Lai
J P
JP
Department of Otolaryngology, Hsiang Ya Hospital, Hunan Medical University, Changsha, People's Republic of China.
Tao
Z D
ZD
Xiao
J Y
JY
Zhao
S P
SP
Tian
Y Q
YQ
D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000276:immunology; D005260:Female; D006415:Hematoporphyrins / Q000627:therapeutic use; D006801:Humans; D007376:Interleukin-2 / Q000097:blood; D007694:Killer Cells, Natural / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000188:drug therapy* / Q000276:immunology; D010778:Photochemotherapy; D011838:Radiation-Sensitizing Agents / Q000627:therapeutic use; D015375:Receptors, Interleukin-2 / Q000097:blood
D006415:Hematoporphyrins; D007376:Interleukin-2; D011838:Radiation-Sensitizing Agents; D015375:Receptors, Interleukin-2; C052552:photocarcinorin