Natural functions of bacterial multidrug transporters.
Bacteria express several multidrug transporters that recognize structurally dissimilar toxic molecules and expel them from cells. These transporters may have evolved to protect bacteria from diverse environmental toxins or to transport specific physiological compounds with the ability to expel drugs being only a fortuitous side effect.
Neyfakh
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Center for Pharmaceutical Biotechnology, University of Illinois, Chicago 60607, USA. neyfakh@uic.edu
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000235:genetics / Q000502:physiology*; D001419:Bacteria / Q000187:drug effects / Q000235:genetics; D018407:Bacterial Physiological Phenomena; D005075:Biological Evolution; D018432:Drug Resistance, Multiple / Q000235:genetics / Q000502:physiology; D008954:Models, Biological
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1