Effect of sucralfate on gastric intramucosal pH in critically ill patients.
OBJECTIVE
To determine whether sucralfate administration affects the tonometric measurement of gastric intramucosal pH (pHi).


METHODS
Non-randomized observational study.


METHODS
General intensive care unit of a teaching hospital.


METHODS
Twenty critically ill, mechanically ventilated, consecutively admitted patients requiring an arterial catheter and nasogastric tube.


METHODS
Tonometer placement and sucralfate administration.


RESULTS
We simultaneously determined tonometer saline PCO2 (PCO2i), arterial blood gases, pH of gastric juice and pHi. These parameters were evaluated immediately before sucralfate administration, and 2 h and 4 h after. We did not detect any change in either PCO2i or pHi after sucralfate administration (PCO2i: basal 6.4 +/- 1.7, 2 h 6.3 +/- 1.7, 4 h 6.3 +/- 1.7; pHi: basal 7.35 +/- 0.13, 2 h 7.36 +/- 0.12, 4 h 7.36 +/- 0.12).


CONCLUSIONS
Sucralfate does not affect the tonometric measurement of PCO2i and pHi.
Calvet
X
X
Internal Medicine Department, Hospital de Sabadell, Barcelona, Spain.
Baigorri
F
F
Duarte
M
M
Joseph
D
D
Saura
P
P
Mas
A
A
Royo
C
C
Artigas
A
A
D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D000897:Anti-Ulcer Agents / Q000627:therapeutic use; D001784:Blood Gas Analysis; D016638:Critical Illness / Q000628:therapy*; D016903:Drug Monitoring; D005260:Female; D005745:Gastric Acidity Determination; D005753:Gastric Mucosa / Q000187:drug effects*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008875:Middle Aged; D012121:Respiration, Artificial; D013392:Sucralfate / Q000627:therapeutic use*; D013997:Time Factors
D000897:Anti-Ulcer Agents; D013392:Sucralfate