title: Chronic administration of a partial agonist at strychnine-insensitive glycine receptors: a novel experimental approach to the treatment of ischemias.
abstract: During the past decade, converging lines of evidence have linked the abnormal release or leak of excitatory amino acids to the neurodegeneration associated with a wide range of pathologies including cerebral ischemias, Huntington's disease, and AIDS dementia (Coyle and Robinson, 1987; Lipton, 1994; Meldrum, 1994). Pharmacological studies indicate that activation of both ionotropic and metabotropic glutamate receptors can substantially contribute to excitotoxic cell damage (Choi, 1992; Pizzi et al., 1993; Sheardown et al., 1993; Xue et al., 1994). Based on these findings, therapeutic strategies based on blunting or blocking glutamatergic transmission may be useful in treating a variety of neurodegenerative disorders.
authors.affiliation: Laboratory of Neuroscience, NIDDK, National Institutes of Health, Bethesda, MD, USA.
authors.forename: L H
authors.initials: LH
authors.lastname: Fossom
authors.forename: P
authors.initials: P
authors.lastname: Skolnick
mesh_terms: D015526:AIDS Dementia Complex / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology; D000596:Amino Acids / Q000494:pharmacology* / Q000627:therapeutic use; D000598:Amino Acids, Cyclic; D000818:Animals; D002545:Brain Ischemia / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D006816:Huntington Disease / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology; D009410:Nerve Degeneration; D009474:Neurons / Q000187:drug effects / Q000502:physiology; D018696:Neuroprotective Agents / Q000494:pharmacology / Q000627:therapeutic use*; D018009:Receptors, Glycine / Q000819:agonists* / Q000037:antagonists & inhibitors; D016194:Receptors, N-Methyl-D-Aspartate / Q000502:physiology; D013331:Strychnine / Q000494:pharmacology
chemical_list: D000596:Amino Acids; D000598:Amino Acids, Cyclic; D018696:Neuroprotective Agents; D018009:Receptors, Glycine; D016194:Receptors, N-Methyl-D-Aspartate; C023863:1-aminocyclopropane-1-carboxylic acid; D013331:Strychnine