In vitro drug susceptibility of Acanthamoeba castellani to chloroquine, ivermectin and fungizon.
In vitro sensitivity of Acanthamoeba castellani was tested to three drugs: Chloroquine, ivermectin and fungizone (amphotericin B). Sensitivity was demonstrated to the latter two compounds but not to chloroquine. Thus ivermectin and amphotericin B show promise as therapeutic agents against this parasite.
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Biotechnology Centre, Institute for Medical Research, Jalan Pahang, Kuala Lumpur, Malaysia.
Radzan
T
T
Sajiri
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Mak
J W
JW
D000048:Acanthamoeba / Q000145:classification / Q000187:drug effects* / Q000254:growth & development; D000563:Amebicides / Q000494:pharmacology*; D000666:Amphotericin B / Q000494:pharmacology*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002738:Chloroquine / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D004351:Drug Resistance; D007559:Ivermectin / Q000494:pharmacology*; D013997:Time Factors
D000563:Amebicides; D000900:Anti-Bacterial Agents; D007559:Ivermectin; D000666:Amphotericin B; D002738:Chloroquine