Cytotoxic lignans from Formosan Hernandia nymphaeifolia.
A new dibenzylbutyrolactone lignan, (--)-6-hydroxyyatein, along with two new furanoid lignans, (--)-hernone [(2R,3S,4R)-(--)-3-hydroxymethyl -4-(3",4",5"-trimethoxybenzoyl)-2-(3,4-dimethoxyphenyl) tetrahydrofuran] and (--)-nymphone [(2R,3S,4R)-(--)-3-hydroxymethyl-4-(3",4",5"-trimethoxybenzoyl)-2- (3,4-methylenedioxyphenyl)tetrahydrofuran], have been isolated and characterized from the trunk bark of Formosan Hernandia nymphaeifolia. The structures of these compounds were determined by means of spectral analyses. These three lignans exhibited cytotoxic activities against P-388, KB16, A549 and HT-29 cell lines.
Chen
I S
IS
Graduate Institute of Pharmaceutical Sciences, Kaohsiung Medical College, Taiwan, Republic of China.
Chen
J J
JJ
Duh
C Y
CY
Tsai
I L
IL
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D002470:Cell Survival / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007624:KB Cells; D017705:Lignans / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D051379:Mice; D015394:Molecular Structure; D010946:Plants, Medicinal; D013624:Taiwan; D014407:Tumor Cells, Cultured
D000972:Antineoplastic Agents, Phytogenic; D017705:Lignans