Responsiveness of aortic rings of cadmium-hypertensive rats to endothelin-1.
Cadmium administered intraperitoneally at a dose of 1 mg/kg/day for 15 days caused a significant increase in mean arterial blood pressure. Endothelin-1 and noradrenaline produced concentration-dependent contractions of aortic rings that attained a lower maximal contraction in cadmium-injected rats as compared with control rats (p < 0.05). On the other hand, responses of aortic rings to different concentrations of potassium chloride did not show a significant difference between the groups. The decreased responsiveness of the aortae of cadmium-hypertensive rats to endothelin-1 and noradrenaline could either be due to an interaction of cadmium with receptors or intracellular signal transduction pathways of these agents, or it may simply reflect the adaptive changes in vascular tissues following hypertension development.
Ozdem
S S
SS
Department of Pharmacology, Faculty of Medicine, Akdeniz University, Antalya, Turkey.
Oğütman
C
C
D000818:Animals; D001011:Aorta / Q000187:drug effects* / Q000503:physiopathology; D002104:Cadmium / Q000494:pharmacology*; D019332:Endothelin-1 / Q000494:pharmacology*; D006973:Hypertension / Q000139:chemically induced* / Q000503:physiopathology; D066298:In Vitro Techniques; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology; D011189:Potassium Chloride / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D014662:Vasoconstrictor Agents / Q000494:pharmacology*
D019332:Endothelin-1; D014662:Vasoconstrictor Agents; D002104:Cadmium; D011189:Potassium Chloride; D009638:Norepinephrine