The effect of ethanol and/or food restriction on coenzyme Q in liver in rats.
The individual and combined effects of ethanol and lovastatin on rats and their prevention by supplemental coenzyme Q10 (CoQ10) was studied. The ethanol and lovastatin findings are reported elsewhere. This paper focuses on the food restriction which occurred in rats fed 35% of energy as ethanol and those control rats pair-fed to the 35% of energy as ethanol group. Six groups of rats received 35% of energy as ethanol (with or without lovastatin and/or CoQ10 treatment). One group served as a 0% ethanol ad libitum control and one 0% ethanol control group was pair-fed to the 35% ethanol group. Rats receiving 35% of energy as ethanol and their pair-fed controls consumed 83% of the energy/day consumed by the ad libitum controls. This was consistent regardless of lovastatin or CoQ10 treatment. Weight gains were 84% of control. The energy reduction was consistently associated with a substantial (48%+) increase in liver CoQ9 concentrations. Reports by others of associations between food restriction and increased longevity in rodents has focused on a decrease in oxidant damage in tissues of food restricted animals. The increase in CoQ levels in the food restricted animals would result in an increase in antioxidant protection and might explain the observed increases in longevity.
Willis
R A
RA
Institute for Biomedical Research, University of Texas, Austin 78712, USA.
Anthony
M
M
Loop
R
R
Llanes
C
C
Folkers
K
K
D000821:Animal Feed; D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D001066:Appetite / Q000187:drug effects; D004562:Electrocardiography; D000431:Ethanol / Q000494:pharmacology*; D005080:Exercise Test; D005508:Food Deprivation / Q000502:physiology*; D005526:Food, Formulated; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000494:pharmacology; D050356:Lipid Metabolism; D008099:Liver / Q000378:metabolism*; D008148:Lovastatin / Q000494:pharmacology; D009206:Myocardium / Q000378:metabolism; D051381:Rats; D014451:Ubiquinone / Q000097:blood / Q000378:metabolism*
D000975:Antioxidants; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D014451:Ubiquinone; D000431:Ethanol; D008148:Lovastatin; C030571:ubiquinone 9