title: A search for the intermediate radical, ONOO, in the reaction between oxygen and nitric oxide in solution.
abstract: The most probable initial reaction between .NO and O2 is direct addition to give the peroxyl radical ONOO.. In view of the potential importance of this radical in biology, we have searched extensively for its formation, using EPR spectroscopy and rapid freezing techniques. At best, only extremely low concentrations were detected, and in most systems, no signals were detectable. We conclude that this radical is unlikely to be of major importance per se in biological systems, in contrast with its one electron adduct, the peroxynitrite anion.
authors.affiliation: Inflammation Research Group, St. Bartholomew's Hospital School of Medicine and Dentistry, London, U.K.
authors.forename: E
authors.initials: E
authors.lastname: Frears
authors.forename: N
authors.initials: N
authors.lastname: Nazhat
authors.forename: D
authors.initials: D
authors.lastname: Blake
authors.forename: M
authors.initials: M
authors.lastname: Symons
mesh_terms: D004578:Electron Spin Resonance Spectroscopy; D005609:Free Radicals / Q000737:chemistry / Q000378:metabolism; D009569:Nitric Oxide / Q000737:chemistry* / Q000378:metabolism; D010100:Oxygen / Q000737:chemistry* / Q000378:metabolism; D012996:Solutions
chemical_list: D005609:Free Radicals; D012996:Solutions; D009569:Nitric Oxide; D010100:Oxygen