Ototoxicity of aminoglycoside drugs in tuberculosis treatment.
The possible ototoxic effect of kanamycin, streptomycin and a standard anti-TB drug combination, used in the treatment of 92 TB patients (7-71 years old), was examined by measuring the highest audible electric bone conduction frequency before and after treatment, using an Audimax 500 audiometer. At the so-called "safe" levels of drug administration it was found that kanamycin was markedly ototoxic, streptomycin very slightly ototoxic and the standard anti-TB drug combination had practically no ototoxic effect. Furthermore, it was found that none of these drugs were gender specific. Lastly, the possible effects of ageing on highest audible bone conduction frequency is discussed.
Voogt
G R
GR
Department Otorhinolaryngology, Medical University of Southern Africa.
Schoeman
H S
HS
D000293:Adolescent; D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D000995:Antitubercular Agents / Q000009:adverse effects*; D002648:Child; D004359:Drug Therapy, Combination; D005260:Female; D006316:Hearing Loss, High-Frequency / Q000139:chemically induced*; D006801:Humans; D007612:Kanamycin / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D013307:Streptomycin / Q000009:adverse effects*; D014376:Tuberculosis / Q000188:drug therapy
D000900:Anti-Bacterial Agents; D000995:Antitubercular Agents; D007612:Kanamycin; D013307:Streptomycin