Prognostic value of basic fibroblast growth factor and its receptor (FGFR-1) in patients with non-small cell lung carcinomas.
Tumour specimens of 206 patients with untreated non-small cell lung carcinomas (NSCLC) were analysed immunohistochemically for the expression of the basic fibroblast growth factor (bFGF) and for its receptor (FGFR-1, Flg). Seventy of the tumours showed weak expression, 109 moderate and 27 high expression of bFGF. Thirty-eight tumours had low expression of FGFR-1, 116 had moderate and 52 cases high expression. Patients with high FGFR-1 expression had significantly shorter survival times than patients with weak or moderate expressions (P < 0.05), but there was no significant correlation between bFGF expression and patient survival. The results of the multivariate analysis demonstrated that FGFR-1 in the presence of stage is not an independent prognostic factor.
Volm
M
M
German Cancer Research Center, Department of Oncological Diagnostics and Therapy, Heidelberg, Germany.
Koomägi
R
R
Mattern
J
J
Stammler
G
G
D002289:Carcinoma, Non-Small-Cell Lung / Q000737:chemistry*; D005260:Female; D016222:Fibroblast Growth Factor 2 / Q000032:analysis*; D000091344:Filaggrin Proteins; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000737:chemistry*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009363:Neoplasm Proteins / Q000032:analysis*; D011379:Prognosis; D017468:Receptors, Fibroblast Growth Factor / Q000032:analysis*
C000717249:FLG protein, human; D000091344:Filaggrin Proteins; D009363:Neoplasm Proteins; D017468:Receptors, Fibroblast Growth Factor; D016222:Fibroblast Growth Factor 2