title: Structure and function of platelet alpha IIb beta 3.
abstract: Platelet aggregation is mediated by the platelet fibrinogen receptor, the alpha IIb beta 3 integrin (glycoprotein IIb-IIIa). This integrin has served as a prototype for studies probing structure-function relationships, cellular modulation of integrin function, and integrin-mediated signaling. Use of new model systems and molecular approaches have helped investigators to make rapid progress in our understanding of these areas, as reviewed here.
authors.affiliation: Department of Pharmacology, University of North Carolina, Chapel Hill 27599, USA.
authors.forename: U P
authors.initials: UP
authors.lastname: Naik
authors.forename: L V
authors.initials: LV
authors.lastname: Parise
mesh_terms: D000818:Animals; D006801:Humans; D008024:Ligands; D008958:Models, Molecular; D010974:Platelet Aggregation; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000737:chemistry*; D015398:Signal Transduction; D013329:Structure-Activity Relationship
chemical_list: D008024:Ligands; D019039:Platelet Glycoprotein GPIIb-IIIa Complex