title: [Risks and side effects of intensified insulin therapy].
abstract: Diabetes mellitus may be accompanied by severe long-term microvascular, neurological and macrovascular complications. Prevention of these complications represents an enormous challenge for the diabetic patients and their doctors. However, if diabetic long-term complications occur, affecting one or more organ systems, it is a major goal to prevent their progression. Both, primary and secondary prevention require a good metabolic control striving for near-normal blood glucose values. Intensified insulin therapy (three or more daily injections or external insulin pump) has been shown to achieve a glycemic control as close to the normal range as possible.
authors.affiliation: Abtellung Endokrinologie und Diabetologie, Universitätsspitals Zürich, Schweiz.
authors.forename: R
authors.initials: R
authors.lastname: Honegger
authors.forename: G A
authors.initials: GA
authors.lastname: Spinas
mesh_terms: D003920:Diabetes Mellitus / Q000097:blood / Q000209:etiology; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000188:drug therapy*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000188:drug therapy*; D003925:Diabetic Angiopathies / Q000097:blood / Q000517:prevention & control; D003929:Diabetic Neuropathies / Q000097:blood / Q000517:prevention & control; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D006801:Humans; D007328:Insulin / Q000008:administration & dosage / Q000009:adverse effects*; D007332:Insulin Infusion Systems; D009765:Obesity; D012307:Risk Factors
chemical_list: D007328:Insulin