[Two kinds of cytokine gene expression in umbilical cord blood of premature and mature neonates].
OBJECTIVE
To study the immunological function of premature and mature neonates.


METHODS
By means of in situ hybridization technique, mRNA expression of interleukin-1 (IL-1) beta and IL-1r alpha in umbilical cord blood of 34 cases was analyzed.


RESULTS
It showed that mRNA expression of IL-1 beta and IL-1r alpha were significantly lower in the group of preterm vaginal delivery resulting from premature rupture of membranes than that of preterm cesarean section with the indication of pregnancy induced hypertension and than that of full term delivery (P < 0.001). No significant difference was found between the latter 2 groups.


CONCLUSIONS
It indicated that gene expression of IL-1 beta and IL-1r alpha probably related to the fetal maturity.
Tang
J
J
People's Hospital, Beijing Medical University.
Zhang
P
P
Liu
F
F
D000328:Adult; D005260:Female; D005312:Fetal Blood / Q000378:metabolism*; D015870:Gene Expression; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000097:blood / Q000276:immunology*; D053590:Interleukin 1 Receptor Antagonist Protein; D007375:Interleukin-1 / Q000235:genetics*; D053583:Interleukin-1beta; D010446:Peptide Fragments / Q000235:genetics*; D011247:Pregnancy; D012333:RNA, Messenger / Q000378:metabolism*; D012795:Sialoglycoproteins / Q000235:genetics*
C507763:IL1RN protein, human; D053590:Interleukin 1 Receptor Antagonist Protein; D007375:Interleukin-1; D053583:Interleukin-1beta; D010446:Peptide Fragments; D012333:RNA, Messenger; D012795:Sialoglycoproteins; C052994:interleukin-1beta (163-171)