[Expression and significance of bcl-2 oncogene protein in follicular lymphoma and lymphoid follicular hyperplasia].
In order to distinguish follicular lymphoma (FL) from follicular hyperplasia (FH), immunohistochemical staining method was used to detect the expression of bcl-2 oncogene protein in 22 cases of FL and 14 cases of FH. The results showed that bcl-2 was positive in 19 and negative in 3 of the 22 FLs, but negative in 12 and weakly positive in 2 of the FHs. These findings suggest that bcl-2 can play an important role in the differential diagnosis of FL and FH.
Wang
J
J
Department of Pathology, Shanxi Tumour Hospital, Taiyuan.
Zhang
J
J
Zhao
X
X
D000328:Adult; D003937:Diagnosis, Differential; D006801:Humans; D008224:Lymphoma, Follicular / Q000235:genetics*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000096:biosynthesis*; D019310:Pseudolymphoma / Q000235:genetics
D019253:Proto-Oncogene Proteins c-bcl-2