title: Group II phospholipase A2 in serum after knee surgery and intramedullary nailing of tibial shaft fracture.
abstract: This prospective study investigates the effect of injury and surgery of cartilage and bone on serum group II phospholipase A2 (PLA2-II) and C-reactive protein (CRP) levels. Serum concentrations of PLA2-II and CRP were measured before and after the operation in nine patients with closed tibial shaft fractures treated by nailing, 11 patients with fractures of lateral tibial plateau treated by bone grafting, and 19 patients with ruptured anterior cruciate ligament treated by reconstruction. The postoperative PLA2-II and CRP values were statistically significantly higher than the pre-operative values in the tibial plateau fracture and ligament rupture groups, whereas the increase in the PLA2-II values in the tibial fracture group was not statistically significant. The highest values of both parameters were found on the second postoperative day. The changes in the PLA2-II and CRP values were parallel in the lateral condyle fracture and in anterior cruciate ligament rupture groups. PLA2-II behaves as an acute phase reactant in the serum of patients undergoing acute and elective knee surgery.
authors.affiliation: Department of Surgery, University of Turku, Finland.
authors.forename: T
authors.initials: T
authors.lastname: Lindström
authors.forename: E
authors.initials: E
authors.lastname: Gullichsen
authors.forename: O
authors.initials: O
authors.lastname: Heinonen
authors.forename: J
authors.initials: J
authors.lastname: Grönroos
authors.forename: T
authors.initials: T
authors.lastname: Nevalainen
authors.forename: J
authors.initials: J
authors.lastname: Niinikoski
mesh_terms: D000209:Acute-Phase Proteins / Q000378:metabolism; D000293:Adolescent; D000328:Adult; D016118:Anterior Cruciate Ligament / Q000601:surgery*; D015415:Biomarkers / Q000097:blood; D016025:Bone Transplantation; D002097:C-Reactive Protein / Q000032:analysis; D005260:Female; D005594:Fracture Fixation, Intramedullary; D006801:Humans; D008297:Male; D008875:Middle Aged; D010741:Phospholipases A / Q000097:blood*; D054467:Phospholipases A2; D011446:Prospective Studies; D013978:Tibial Fractures / Q000201:enzymology* / Q000601:surgery*; D013997:Time Factors
chemical_list: D000209:Acute-Phase Proteins; D015415:Biomarkers; D002097:C-Reactive Protein; D010741:Phospholipases A; D054467:Phospholipases A2