title: [Development of an anti-HIV gene therapy based on the antiviral properties of beta interferon].
abstract: The aim of our work is to explore the use of IFN-beta for gene therapy in the HIV-infection. Transduction of various HIV target cells with a retroviral vector that carries the Hu-IFN-beta coding sequence under constitutive low expression control, confers resistance to HIV without affecting cell replication or function. After transduction, lymphocytes from HIV-infected patients develop resistance to the endogenous virus, provided the cells are derived from individuals with a CD4 cell count higher than 200 per mm3.
authors.affiliation: UMR 177 du CNRS, Institut Curie, Centre Universitaire, Orsay.
authors.forename: E
authors.initials: E
authors.lastname: De Maeyer
authors.forename: V
authors.initials: V
authors.lastname: Vieillard
authors.forename: I
authors.initials: I
authors.lastname: Cremer
authors.forename: V
authors.initials: V
authors.lastname: Rousseau
authors.forename: C
authors.initials: C
authors.lastname: Jacomet
authors.forename: P
authors.initials: P
authors.lastname: Debré
authors.forename: W
authors.initials: W
authors.lastname: Rozenbaum
authors.forename: B
authors.initials: B
authors.lastname: Autran
authors.forename: E
authors.initials: E
authors.lastname: Lauret
mesh_terms: D019380:Anti-HIV Agents / Q000008:administration & dosage / Q000627:therapeutic use; D015870:Gene Expression; D015316:Genetic Therapy / Q000379:methods; D005822:Genetic Vectors; D015658:HIV Infections / Q000628:therapy*; D006801:Humans; D016899:Interferon-beta / Q000008:administration & dosage / Q000235:genetics* / Q000627:therapeutic use; D008214:Lymphocytes / Q000166:cytology / Q000276:immunology; D012190:Retroviridae; D014779:Virus Replication / Q000187:drug effects
chemical_list: D019380:Anti-HIV Agents; D016899:Interferon-beta