title: Postoperative hyperamylasaemia in cardiac surgery.
abstract: The mechanism of postoperative hyperamylasaemia was studied in 48 patients undergoing coronary artery bypass grafting (CABG). Mild hyperamylasaemia developed in 87% of the patients, and in 10% the serum amylase activity was > 1000 U/l. Serial measurements of serum salivary (S-) and pancreatic (P-) isoamylases indicated that hyperamylasaemia was highest 24 hours after CABG and consisted mainly of P-amylase component. Serum creatinine, creatinine clearance and urinary albumin concentration remained normal after CABG, excluding severe renal damage. The fractional clearance (i.e. relative to creatinine clearance) of P-amylase decreased more than of S-amylase (from 3.6 to 0.9% vs 1.3 to 0.8%). Decreased rate of excretion into urine, rather than pancreatic cellular damage, is the main source of hyperamylasaemia after CABG.
authors.affiliation: Department of Surgery, Kuopio University Hospital, Finland.
authors.forename: H
authors.initials: H
authors.lastname: Paajanen
authors.forename: A
authors.initials: A
authors.lastname: Harmoinen
authors.forename: T
authors.initials: T
authors.lastname: Sisto
authors.forename: M
authors.initials: M
authors.lastname: Tarkka
authors.forename: I
authors.initials: I
authors.lastname: Nordback
mesh_terms: D000368:Aged; D000681:Amylases / Q000097:blood / Q000378:metabolism* / Q000652:urine; D000704:Analysis of Variance; D001026:Coronary Artery Bypass / Q000009:adverse effects*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007527:Isoenzymes / Q000097:blood / Q000378:metabolism* / Q000652:urine; D016014:Linear Models; D008297:Male; D008659:Metabolic Diseases / Q000175:diagnosis / Q000201:enzymology / Q000209:etiology*; D008875:Middle Aged; D010195:Pancreatitis / Q000175:diagnosis / Q000209:etiology / Q000378:metabolism; D011184:Postoperative Period; D011300:Preoperative Care
chemical_list: D007527:Isoenzymes; D000681:Amylases