title: Synergestic effects of noise and aminoglycoside antibiotic (gentamicin) on auditory function in the gerbil.
abstract: Exposure to excessive noise can cause auditory impairment in people as well as in animals, which can be aggravated by many different ototoxic substances, such as aminoglycosides. In the present study, the gerbil was selected as the experimental animal because the gerbil has low-frequency auditory sensitivity that is similar to human beings. Auditory function in gerbils upon exposure to noise and/or gentamicin was evaluated from non-invasive records of brainstem auditory evoked potentials (BAEPs). Fifty mature male Mongolian gerbils were divided randomly into four groups. The control group was exposed neither to noise nor to gentamicin. The noise group was exposed to 100dBA noise ten hours a day for four weeks. The gentamicin group was treated with one dose of gentamicin, 75 mg/Kg i.m., daily for four weeks. The noise + gentamicin group was exposed concurrently to both noise and gentamicin treatment. BAEPs were recorded from all gerbils 24 hours before any experimental treatment, then every week for eight consecutive weeks. Long-term exposure to noise and/or gentamicin treatment was found to reduce gerbil's body weight. The increase in auditory threshold upon concurrent exposure to both noise and gentamicin treatment (evaluated from BAEPs) exceeded the sum of effects caused by exposure to noise alone and to gentamicin alone. Although differences of peak or interpeak latencies among the four groups were not statistically significant, large standard deviations were noted in the noise+gentamicin group. Thus the apparent threshold shifts in gerbils indicated a major noise and/or gentamicin induced auditory impairment to the cochlea, and the slight latency variations probably suggested a minor injury to the auditory pathways. We emphasize that noise and aminoglycoside antibiotic gentamicin can cause damage to the hearing ability at the frequency range vital to human speech recognition, and their effects are synergetic.
authors.affiliation: Department of Physiology, Kaohsiung Medical College, Taiwan, Republic of China.
authors.forename: T J
authors.initials: TJ
authors.lastname: Chen
authors.forename: S S
authors.initials: SS
authors.lastname: Chen
authors.forename: C H
authors.initials: CH
authors.lastname: Lin
authors.forename: Y L
authors.initials: YL
authors.lastname: Hsieh
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000633:toxicity*; D001835:Body Weight / Q000187:drug effects; D016057:Evoked Potentials, Auditory, Brain Stem / Q000187:drug effects*; D005839:Gentamicins / Q000633:toxicity*; D005849:Gerbillinae; D006309:Hearing / Q000187:drug effects; D008297:Male; D009622:Noise / Q000009:adverse effects*; D012684:Sensory Thresholds / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D005839:Gentamicins