title: Rat chromosome 1: regional localization of seven genes (Slc9a3, Srd5a1, Esr, Tcp1, Grik5, Tnnt3, Jak2) and anchoring of the genetic linkage map to the cytogenetic map.
abstract: Seven genes were regionally localized on rat Chromosome (Chr) 1, from 1p11 to 1q42, and two of these genes were also included in a linkage map. This mapping work integrates the genetic linkage map and the cytogenetic map, and allows us to orient the linkage map with respect to the centromere, and to deduce the approximate position of the centromere in the linkage map. These mapping data also indicate that the Slc9a3 gene, encoding the Na+/H+ exchanger 3, is an unlikely candidate for the blood pressure loci assigned to rat Chr 1. These new localizations expand comparative mapping between rat Chr 1 and mouse or human chromosomes.
authors.affiliation: Département de Biologie Moléculaire, Université Libre de Bruxelles, Rue des Chevaux, 67, B-1640 Rhode-Saint-Genèse, Belgium.
authors.forename: C
authors.initials: C
authors.lastname: Szpirer
authors.forename: J
authors.initials: J
authors.lastname: Szpirer
authors.forename: F
authors.initials: F
authors.lastname: Tissir
authors.forename: E
authors.initials: E
authors.lastname: Stephanova
authors.forename: P
authors.initials: P
authors.lastname: Vanvooren
authors.forename: T W
authors.initials: TW
authors.lastname: Kurtz
authors.forename: N
authors.initials: N
authors.lastname: Iwai
authors.forename: T
authors.initials: T
authors.lastname: Inagami
authors.forename: M
authors.initials: M
authors.lastname: Pravenec
authors.forename: V
authors.initials: V
authors.lastname: Kren
authors.forename: K
authors.initials: K
authors.lastname: Klinga-Levan
authors.forename: G
authors.initials: G
authors.lastname: Levan
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000235:genetics; D002503:Centromere / Q000235:genetics; D056404:Chaperonin Containing TCP-1; D018833:Chaperonins / Q000235:genetics; D042944:Cholestenone 5 alpha-Reductase; D002874:Chromosome Mapping / Q000379:methods*; D002875:Chromosomes; D008040:Genetic Linkage; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D053614:Janus Kinase 2; D007608:Kainic Acid / Q000378:metabolism; D051379:Mice; D010088:Oxidoreductases / Q000235:genetics; D011505:Protein-Tyrosine Kinases / Q000235:genetics; D011518:Proto-Oncogene Proteins; D051381:Rats; D011917:Rats, Inbred Lew; D011918:Rats, Inbred SHR; D011959:Receptors, Estradiol / Q000235:genetics; D017470:Receptors, Glutamate / Q000235:genetics / Q000378:metabolism; D017923:Sodium-Hydrogen Exchangers / Q000235:genetics; D014336:Troponin / Q000235:genetics
chemical_list: D011518:Proto-Oncogene Proteins; D011959:Receptors, Estradiol; D017470:Receptors, Glutamate; D017923:Sodium-Hydrogen Exchangers; C533304:TCP1 protein, human; C533315:Tcp1 protein, mouse; C533316:Tcp1 protein, rat; D014336:Troponin; D010088:Oxidoreductases; D042944:Cholestenone 5 alpha-Reductase; D011505:Protein-Tyrosine Kinases; C507924:JAK2 protein, human; C507926:Jak2 protein, mouse; C507927:Jak2 protein, rat; D053614:Janus Kinase 2; D056404:Chaperonin Containing TCP-1; D018833:Chaperonins; D007608:Kainic Acid