Animal survival related to acute blood pressure response in global cerebral ischemia in rats.
The increase in mean arterial blood pressure (MABP) during global cerebral ischemia constitutes a compensatory and protective mechanism, regulated by the Central Nervous System, in response to the accumulation of different toxic compounds in the brain stem. The relationship between MABP increases and improved tolerance by the animals to ischemia is discussed.
Herguido
M J
MJ
Department of Neurosurgery, Hospital La Paz, Madrid, Spain.
Carceller
F
F
Madero
R
R
Roda
J M
JM
D000818:Animals; D001157:Arterial Occlusive Diseases / Q000401:mortality / Q000503:physiopathology; D002545:Brain Ischemia / Q000150:complications / Q000401:mortality / Q000503:physiopathology*; D002339:Carotid Arteries / Q000601:surgery; D004195:Disease Models, Animal; D005260:Female; D006973:Hypertension / Q000209:etiology / Q000503:physiopathology*; D016548:Prosencephalon / Q000098:blood supply* / Q000503:physiopathology; D051381:Rats; D017208:Rats, Wistar; D016019:Survival Analysis