title: Functional promoter polymorphism of the human serotonin transporter: lack of association with panic disorder.
abstract: To probe the hypothesis of a role for a functionally relevant 44 bp insertion/deletion of the serotonin transporter promoter in the aetiopathogenesis of panic disorder, we determined the allele frequency of the variant in two samples (combined n = 158) of panic disorder patients (DSMIII-R) and compared it with its allele frequency in two ethnically matched control samples (combined n = 169). The fact that no difference could be observed (x 2 analysis) argues against a major role for this serotonin transporter promoter polymorphism in the aetiopathogenesis of panic disorder.
authors.affiliation: Department of Psychiatry, Julius-Maximilians-University, Wurzburg, Germany.
authors.forename: J
authors.initials: J
authors.lastname: Deckert
authors.forename: M
authors.initials: M
authors.lastname: Catalano
authors.forename: A
authors.initials: A
authors.lastname: Heils
authors.forename: D
authors.initials: D
authors.lastname: Di Bella
authors.forename: F
authors.initials: F
authors.lastname: Friess
authors.forename: E
authors.initials: E
authors.lastname: Politi
authors.forename: P
authors.initials: P
authors.lastname: Franke
authors.forename: M M
authors.initials: MM
authors.lastname: Nöthen
authors.forename: W
authors.initials: W
authors.lastname: Maier
authors.forename: L
authors.initials: L
authors.lastname: Bellodi
authors.forename: K P
authors.initials: KP
authors.lastname: Lesch
mesh_terms: D000483:Alleles; D002352:Carrier Proteins / Q000235:genetics*; D016022:Case-Control Studies; D004198:Disease Susceptibility; D005006:Ethnicity / Q000235:genetics; D005838:Genotype; D005858:Germany / Q000208:ethnology; D006801:Humans; D007558:Italy / Q000208:ethnology; D008562:Membrane Glycoproteins / Q000235:genetics*; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; D016584:Panic Disorder / Q000453:epidemiology / Q000235:genetics*; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic / Q000235:genetics*; D050486:Serotonin Plasma Membrane Transport Proteins
chemical_list: D002352:Carrier Proteins; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins