Evidence for association of HLA-A2 allele with onset age of Alzheimer's disease.
Our earlier studies had suggested a possible association between the HLA-A2 allele and Alzheimer's disease (AD). In the present study we tested the hypothesis that A2 is associated with earlier AD onset. We performed two independent studies: a collaborative study with 111 patients and a confirmatory study with 96 patients. We found similar patterns of reduced age at onset as a function of A2 in both data sets. Overall, A2 was associated with a significant 3-year shift to earlier onset. The effects of A2 and epsilon 4 on age at onset appeared additive. Our results suggest A2, or a closely linked gene, modulates onset age of AD. Association with A2 would suggest an immune/inflammatory response mechanism for AD.
Payami
H
H
Department of Molecular, Oregon Health Sciences University, Portland 97201, USA.
Schellenberg
G D
GD
Zareparsi
S
S
Kaye
J
J
Sexton
G J
GJ
Head
M A
MA
Matsuyama
S S
SS
Jarvik
L F
LF
Miller
B
B
McManus
D Q
DQ
Bird
T D
TD
Katzman
R
R
Heston
L
L
Norman
D
D
Small
G W
GW
D017668:Age of Onset; D000368:Aged; D000483:Alleles; D000544:Alzheimer Disease / Q000453:epidemiology / Q000235:genetics* / Q000276:immunology*; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics; D005260:Female; D005838:Genotype; D015789:HLA-A2 Antigen / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010641:Phenotype
D053327:Apolipoprotein E4; D001057:Apolipoproteins E; D015789:HLA-A2 Antigen