title: [Genetically engineered mice for study of human hypertension].
abstract: Human essential hypertension is generally recognized as a multifactorial disease based on genetic diathesis. Despite the usefulness of SHR and Dahl rats as laboratory tools, the genetic diathesis including the development of hypertension in these rats remains unclear. Rapid advances in embryonic engineering and molecular biological techniques may make it possible to develop transgenic mice and gene-targeted mice and open new avenues for the molecular investigation of human disease. This report introduces genetically engineered mice with hypertension and hypotension.
authors.affiliation: Laboratory Animal Research Center, University of Tsukuba.
authors.forename: F
authors.initials: F
authors.lastname: Sugiyama
authors.forename: K
authors.initials: K
authors.lastname: Taniguchi
authors.forename: A
authors.initials: A
authors.lastname: Fukamizu
authors.forename: K
authors.initials: K
authors.lastname: Yagami
mesh_terms: D000818:Animals; D009320:Atrial Natriuretic Factor / Q000235:genetics; D004195:Disease Models, Animal; D006801:Humans; D006973:Hypertension / Q000235:genetics; D016234:Kallikrein-Kinin System / Q000235:genetics; D051379:Mice; D008822:Mice, Transgenic; D009154:Mutation; D019001:Nitric Oxide Synthase / Q000235:genetics; D051381:Rats; D018341:Receptors, Adrenergic, alpha-2 / Q000235:genetics; D012084:Renin-Angiotensin System / Q000235:genetics; D017923:Sodium-Hydrogen Exchangers / Q000235:genetics
chemical_list: D018341:Receptors, Adrenergic, alpha-2; D017923:Sodium-Hydrogen Exchangers; D009320:Atrial Natriuretic Factor; D019001:Nitric Oxide Synthase