Effect of viscum album in the inhibition of lung metastasis in mice induced by B16F10 melanoma cells.
Effect of Iscador, an extract from semiparasitic plant Viscum Album on the inhibition of lung metastatic colony formation induced by B16F10 melanoma cells was studied in mice. Simultaneous administration of drug (1.66 mg/dose) and B16F10 melanoma cells could inhibit lung nodule formation by 92%. Prophylactic drug administration produced and inhibition of 78.6% and drug administration five days after tumour induction produced 68.16% inhibition of lung nodule formation. Lung hydroxyproline and serum sialic acid levels were also lower in the tumour bearing animals treated with Viscum Album. The animals treated with simultaneous drug administration had an increase of 71.34% in their life span.
Antony
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Amala Cancer Research Centre, Amala Nagar Thrissur, Kerala, India.
Kuttan
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Kuttan
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D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D014408:Biomarkers, Tumor / Q000097:blood / Q000378:metabolism; D006909:Hydroxyproline / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000556:secondary*; D008546:Melanoma, Experimental / Q000188:drug therapy* / Q000378:metabolism / Q000556:secondary*; D051379:Mice; D008810:Mice, Inbred C57BL; D014784:Mistletoe / Q000737:chemistry; D019158:N-Acetylneuraminic Acid / Q000097:blood; D009368:Neoplasm Transplantation; D010936:Plant Extracts / Q000494:pharmacology*; D010940:Plant Proteins; D010946:Plants, Medicinal
D000972:Antineoplastic Agents, Phytogenic; D014408:Biomarkers, Tumor; D010936:Plant Extracts; D010940:Plant Proteins; C077177:viscum album peptide; D019158:N-Acetylneuraminic Acid; D006909:Hydroxyproline