[Systemic inflammatory reactions to extracorporeal therapy measures (II): Cardiopulmonary bypass].
About 65,000 cardiac patients undergo surgery annually in Germany with the assistance of cardiopulmonary bypass. The "post pump inflammatory response" (the systemic and myocardial inflammatory response syndrome post cardiac surgery), triggered at least in part by the cardiopulmonary bypass, contributes substantially towards morbidity (e.g., myocardial depression) and mortality in these patients. The main mechanisms underlying this inflammatory response are the complement cascade, the activation of blood cells, the release of cytokines and the induction to nitric oxide synthesis. The relative importance of each individual factor, however, is still a matter of debate. Scoring systems and measurements of tumor necrosis factor-alpha, as well as soluble tumor necrosis factor receptors, allow the early detection of an "escalating inflammatory response" in 2-10% of all patients, which is associated with a worse prognosis. Therapeutic attempts to suppress these systemic and myocardial inflammatory reactions focus on blockade of the complement system, coating of CPB membranes with heparin, leucocyte depletion and attenuation of leucocyte function, elimination of toxins and mediators by means of hemofiltration, as well as on the administration of antiproteases, antioxidants, oxygen radical scavengers and also of immune globulins.
Prondzinsky
R
R
Lehrstuhl für Kardiologische Intensivmedizin, Martin-Luther-Universität Halle-Wittenberg, Halle/Saale.
Müller-Werdan
U
U
Pilz
G
G
Witthaut
R
R
Stabenow
I
I
Werdan
K
K
Zerkowski
H R
HR
D002315:Cardiopulmonary Bypass / Q000295:instrumentation*; D016207:Cytokines / Q000097:blood; D006801:Humans; D008213:Lymphocyte Activation / Q000502:physiology; D009206:Myocardium / Q000276:immunology; D009569:Nitric Oxide / Q000097:blood; D018124:Receptors, Tumor Necrosis Factor / Q000097:blood; D015996:Survival Rate; D018746:Systemic Inflammatory Response Syndrome / Q000175:diagnosis / Q000276:immunology* / Q000401:mortality; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D016207:Cytokines; D018124:Receptors, Tumor Necrosis Factor; D014409:Tumor Necrosis Factor-alpha; D009569:Nitric Oxide