Cat-301 immunoreactivity in the lateral geniculate nucleus and visual cortex of the strabismic amblyopic cat.
OBJECTIVE
It was investigated whether alterations in neuronal structure and function occasioned by strabismic amblyopia also may be reflected in alterations in the expression on Y type neurons of a Cat-301 antibody sensitive antigen in the lateral geniculate nucleus (LGN) and cortex of our cat model of strabismic amblyopia.


RESULTS
The percentage of positively labelled cells was reduced in LGN laminae that received input from the deviated eye in strabismic amblyopic cats compared with normal cats. In the strabismic cortex, the density of immunopositive neurons was significantly reduced compared with normal the effect being most pronounced in layer IV.


CONCLUSIONS
Despite previous physiological recordings indicating a decrease in X-cell associated acuity in strabismic amblyopia, the present findings imply that the changes in the early visual experience occasioned by strabismus also produce specific molecular changes in the Y neuronal class.
Yin
Z Q
ZQ
School of Optometry, University of New South Wales, Sydney, Australia.
Crewther
S G
SG
Pirie
B
B
Crewther
D P
DP
D000550:Amblyopia / Q000150:complications / Q000378:metabolism*; D000818:Animals; D000911:Antibodies, Monoclonal; D000954:Antigens, Surface / Q000378:metabolism; D002415:Cats; D011508:Chondroitin Sulfate Proteoglycans / Q000378:metabolism*; D004195:Disease Models, Animal; D005829:Geniculate Bodies / Q000378:metabolism*; D007150:Immunohistochemistry; D009474:Neurons / Q000378:metabolism; D013285:Strabismus / Q000150:complications / Q000378:metabolism*; D014793:Visual Cortex / Q000378:metabolism*; D014795:Visual Pathways / Q000378:metabolism
D000911:Antibodies, Monoclonal; D000954:Antigens, Surface; D011508:Chondroitin Sulfate Proteoglycans