title: [Contribution to the treatment of acute bovine mastitis with cefquinome].
abstract: Cefquinome is the first 4th generation cephalosporin antibiotic developed for use in veterinary medicine. A European multicentre study established a high in vitro activity for this modern antimicrobial drug against a wide spectrum of bovine pathogens. Gram-positive and gram-negative mastitis agents were inactivated even at very low active ingredient concentrations, including Enterobacteriaceae which are often resistant to other drugs. The results of clinical trials using experimental E. coli mastitis as an example demonstrate the efficacy of cefquinome in vivo. Parenteral administration at a dose rate of 1 mg/kg body weight when compared with conventional therapy using a control drug with equally good in vitro activity, produced significantly better therapeutic results.
authors.affiliation: Hebrew University of Jerusalem, Koret School of Veterinary Medicine, Veterinary Teaching Hospital, Israel.
authors.forename: N Y
authors.initials: NY
authors.lastname: Shpigel
authors.forename: P
authors.initials: P
authors.lastname: Schmid
mesh_terms: D000818:Animals; D002417:Cattle; D002511:Cephalosporins / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004756:Enterobacteriaceae Infections / Q000188:drug therapy / Q000662:veterinary; D004927:Escherichia coli Infections / Q000188:drug therapy / Q000662:veterinary; D005260:Female; D016905:Gram-Negative Bacterial Infections / Q000188:drug therapy / Q000662:veterinary; D016908:Gram-Positive Bacterial Infections / Q000188:drug therapy / Q000662:veterinary; D008414:Mastitis, Bovine / Q000188:drug therapy* / Q000382:microbiology; D015337:Multicenter Studies as Topic
chemical_list: D002511:Cephalosporins; C068212:cefquinome