title: Indium as internal standard in square wave anodic stripping analysis of lead in blood with microelectrode arrays.
abstract: The toxic effects of lead on humans, especially children have been well documented. ASV has been an important technique in the analysis of lead in blood of humans. This research has demonstrated that indium(III) can be used as an internal standard in the analysis of lead in blood samples with mercury film microelectrode arrays. Indium is a good choice because of a low endogenous blood concentration and because baseline separation of anodic stripping peaks among Cd, In, and Pb can be achieved under appropriate conditions. The concentration of sodium bromide strongly influences the resolution of these metals and the sensitivity of ASV to In(III) in solution. Square wave anodic stripping voltammetry together with screen-printed microelectrode arrays showed that the ratio of the anodic stripping peak currents of Pb and In varies linearly with the concentration of Pb in blood samples ranging from 1.2 to 30.0 micrograms/dL. The average intraassay precision (rsd) was 6.7%.
authors.affiliation: UCSF/SFGH Metals Laboratory, University of California 94110, USA.
authors.forename: T Z
authors.initials: TZ
authors.lastname: Liu
authors.forename: D
authors.initials: D
authors.lastname: Lai
authors.forename: J D
authors.initials: JD
authors.lastname: Osterloh
mesh_terms: D004563:Electrochemistry; D006801:Humans; D007202:Indicators and Reagents; D007204:Indium / Q000737:chemistry*; D007854:Lead / Q000097:blood*; D008839:Microelectrodes; D012015:Reference Standards
chemical_list: D007202:Indicators and Reagents; D007204:Indium; D007854:Lead