Design of peptide and polypeptide vaccines.
Advances have been made in the development of vaccines based on synthetic peptides and polypeptides representing tumor-associated antigens and protective epitopes of viruses and parasites. Advances within the past year include the design of vaccines based on artificial proteins, for example multiantigen peptides, branched polypeptides, fusion and recombinant peptides, as well as single T cell epitopes and tumor antigen peptides. Although peptide vaccines are not in use as yet, their potential is being explored.
Ben-Yedidia
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Department of Immunology, Weizmann Institute of Science, Rehovot, Israel.
Arnon
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D016915:AIDS Vaccines / Q000138:chemical synthesis; D000818:Animals; D019496:Cancer Vaccines / Q000138:chemical synthesis; D004337:Drug Carriers; D015195:Drug Design; D006801:Humans; D007252:Influenza Vaccines / Q000138:chemical synthesis; D017780:Malaria Vaccines / Q000138:chemical synthesis; D010455:Peptides / Q000138:chemical synthesis*; D015202:Protein Engineering; D012552:Schistosomiasis / Q000517:prevention & control; D014614:Vaccines, Synthetic; D014780:Viruses
D016915:AIDS Vaccines; D019496:Cancer Vaccines; D004337:Drug Carriers; D007252:Influenza Vaccines; D017780:Malaria Vaccines; D010455:Peptides; D014614:Vaccines, Synthetic