title: The use of a coral composite implant containing bone morphogenetic protein to repair a segmental tibial defect in sheep.
abstract: A composite implant consisting of a coral cylinder, moose bone morphogenetic protein and type IV collagen was used to repair a segmental tibial defect in sheep. Healing, related variance in mechanical strength and immune responses were evaluated. In comparison with a coral control, a larger amount of newly formed external callus was observed in the composite group at 6 weeks. The maximal torque capacity, maximal angular deformation at failure and bone stiffness of a healed osteotomised tibia recovered 113%, 117% and 120% in the coral controls and 67%, 92% and 79% in the composite implants against the corresponding contralateral tibia at 16 weeks respectively. A significantly elevated anti-BMP antibody was detectable in the composite group at 3 and 6 weeks. Augmented bone formation at an early stage and weakened torsional performance at a later stage in the composite implants may indicate the phase-specific osteoinduction and the immune response of xenogenic BMP with time.
authors.affiliation: Institute of Medical Technology, University of Tampere, Finland.
authors.forename: T J
authors.initials: TJ
authors.lastname: Gao
authors.forename: T S
authors.initials: TS
authors.lastname: Lindholm
authors.forename: B
authors.initials: B
authors.lastname: Kommonen
authors.forename: P
authors.initials: P
authors.lastname: Ragni
authors.forename: A
authors.initials: A
authors.lastname: Paronzini
authors.forename: T C
authors.initials: TC
authors.lastname: Lindholm
authors.forename: P
authors.initials: P
authors.lastname: Jalovaara
authors.forename: M R
authors.initials: MR
authors.lastname: Urist
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena; D019485:Bone Morphogenetic Proteins / Q000627:therapeutic use*; D001861:Bone Regeneration; D002851:Chromatography, High Pressure Liquid; D003063:Cnidaria; D004195:Disease Models, Animal; D004867:Equipment Design; D004869:Equipment Safety; D005260:Female; D017102:Fracture Healing / Q000502:physiology; D008297:Male; D010784:Photomicrography; D019736:Prostheses and Implants; D011859:Radiography; D012016:Reference Values; D012756:Sheep; D013978:Tibial Fractures / Q000000981:diagnostic imaging / Q000601:surgery*
chemical_list: D019485:Bone Morphogenetic Proteins