title: The effect of short-term fasting, apolipoprotein E gene polymorphism, and sex on plasma lipids.
abstract: The effect of 1 wk of supervised fasting on plasma lipid concentrations in subjects with different apolipoprotein E (apo E) phenotypes was studied in 58 healthy free-living volunteers. The participants consumed an 870-kJ(208 kcal)/d liquid diet containing fruit and berry juices, tea, and water. The decline in plasma total cholesterol during 1 wk of fasting was 0.46 mmol/L in women and 0.35 mmol/L in men. The decreases were significant in both women and men. The response patterns of plasma total cholesterol were not significantly different between the sexes. In men, the changes in plasma low-density-lipoprotein cholesterol during the fast differed significantly (P = 0.0181) between the apo E phenotypes, whereas in women there were no differences due to phenotype (P = 0.695). The magnitude of the change in plasma triacylglycerol during the fast was different between the sexes (P = 0.0099). The changes in plasma triacylglycerols differed significantly between apo E phenotype groups in men (P = 0.0295) but not in women (P = 0.0661). Statistical comparison between different apo E phenotypes was performed with and without the small apo E3,2+E2,2 group, with essentially similar results. During fasting, plasma high-density-lipoprotein cholesterol concentrations decreased slightly but not significantly. The study shows significant differences in the associations of apo E alleles and sex on plasma lipid responses during fasting and illustrates the importance of gene-diet interactions in the regulation of lipid metabolism in humans.
authors.affiliation: Department of Medical Biochemistry, University of Tampere Medical School, Finland. bltele@uta.fi
authors.forename: T
authors.initials: T
authors.lastname: Lehtimäki
authors.forename: H
authors.initials: H
authors.lastname: Frankberg-Lakkala
authors.forename: T
authors.initials: T
authors.lastname: Solakivi
authors.forename: A M
authors.initials: AM
authors.lastname: Koivisto
authors.forename: P
authors.initials: P
authors.lastname: Laippala
authors.forename: C
authors.initials: C
authors.lastname: Ehnholm
authors.forename: H
authors.initials: H
authors.lastname: Jokela
authors.forename: T
authors.initials: T
authors.lastname: Koivula
authors.forename: T
authors.initials: T
authors.lastname: Nikkari
mesh_terms: D001057:Apolipoproteins E / Q000235:genetics*; D002784:Cholesterol / Q000097:blood*; D005215:Fasting; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012737:Sex Factors; D014280:Triglycerides / Q000097:blood*
chemical_list: D001057:Apolipoproteins E; D014280:Triglycerides; D002784:Cholesterol