Galantide improves social memory in rats.
The role of galanin in memory paradigms has been largely evaluated. The galanin-antagonist galantide, a chimeric peptide obtained from amino acids 1-13 of galanin attached to the C-terminal fragment of bradykinin, has been found to improve social memory in 'social recognition' test when i.c.v. administered at doses varying from 6-6000 nmoles.
Arletti
R
R
Department of Biomedical Sciences, University of Modena, Italy.
Benelli
A
A
Cavazzuti
E
E
Bertolini
A
A
D000818:Animals; D003071:Cognition / Q000187:drug effects; D003463:Cues; D019004:Galanin / Q000031:analogs & derivatives* / Q000494:pharmacology; D007276:Injections, Intraventricular; D008297:Male; D008568:Memory / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D012919:Social Behavior; D013373:Substance P / Q000031:analogs & derivatives* / Q000494:pharmacology
C074975:galantide; D013373:Substance P; D019004:Galanin