title: Extensive burns caused by the abusive use of photosensitizing agents.
abstract: Psoralens are photosensitizing agents used in dermatology as reinforcements in psoralen ultraviolet A-range therapy. We report observations of 14 young women hospitalized for severe burns caused by abusive use of psoralens. The burns were of superficial and deep second-degree depth and covered more than 76% of the body surface on average. All patients needed fluid resuscitation. Hospital stay was 11 days on average. Healing was obtained without skin grafting in all cases. Among the six patients who responded to the mailed questionnaire, negative effects are now present in all patients as inflammatory peaks. Two patients have esthetic sequelae such as dyschromia and scars. The misuse of photosensitizing agents poses many problems. These accidents are very expensive. The largeness of the burned surface can involve a fatal prognosis. And finally, one can suspect that a much larger portion of the population regularly uses these products without any serious accident. In this case carcinogenesis can be expected.
authors.affiliation: Centre de Traitement des Brúlés, Hôpital St Luc., Lyon, France.
authors.forename: F
authors.initials: F
authors.lastname: Braye
authors.forename: J
authors.initials: J
authors.lastname: Latarjet
authors.forename: J L
authors.initials: JL
authors.lastname: Foyatier
authors.forename: J P
authors.initials: JP
authors.lastname: Comparin
authors.forename: P
authors.initials: P
authors.lastname: Tranchand
authors.forename: C
authors.initials: C
authors.lastname: Boucaud
mesh_terms: D000293:Adolescent; D000328:Adult; D002056:Burns / Q000209:etiology* / Q000503:physiopathology; D005260:Female; D005440:Fluid Therapy; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D007902:Length of Stay; D008730:Methoxsalen / Q000009:adverse effects*; D008875:Middle Aged; D017319:Photosensitizing Agents / Q000009:adverse effects*; D019966:Substance-Related Disorders; D016896:Treatment Outcome
chemical_list: D017319:Photosensitizing Agents; D008730:Methoxsalen