title: Sensory gating deficit following cocaine exposure in the rat.
abstract: The purpose of this research was to examine changes in the ratio and amplitude of the N40 component of the auditory event-related potential (ERP) in the paired conditioning (C) test (T) stimulation paradigm following subchronic cocaine/vehicle administration. Free moving rats received cocaine (47.5 mg/kg) or saline for 7 consecutive days in a longitudinal crossover design. ERPs were recorded 4 and 7 days after each treatment and again 4 and 7 days following withdrawal of the drug/vehicle. Cocaine led to a progressive increase in the T/C ratio indicating impaired inhibition of the test response. This trend continued throughout the 7-day drug regimen. Following withdrawal of the drug the T/C ratio gradually normalized over the next 7 days but remained elevated at 4 days postdrug. A significant increase in the test response accompanied by a less pronounced decrease in the conditioning response accounted for the observed results. Behavioral state as measured on a rating scale during ERP sampling did not differ across experimental conditions.
authors.affiliation: Department of Psychiatry, University of California, San Francisco, USA. asalamy@itsa.ucsf.edu
authors.forename: A
authors.initials: A
authors.lastname: Salamy
authors.forename: M
authors.initials: M
authors.lastname: Salfi
authors.forename: G
authors.initials: G
authors.lastname: Fein
mesh_terms: D000161:Acoustic Stimulation; D000818:Animals; D003042:Cocaine / Q000494:pharmacology*; D003213:Conditioning, Psychological / Q000187:drug effects; D005071:Evoked Potentials / Q000187:drug effects; D008297:Male; D009294:Narcotics / Q000494:pharmacology*; D051381:Rats; D013216:Reflex, Startle / Q000187:drug effects*
chemical_list: D009294:Narcotics; D003042:Cocaine