title: Surgical treatment of acquired ventricular septal defects in the elderly.
abstract: OBJECTIVE
  As the population continues to age, older patients are being referred for repair of acquired ventricular septal defect (VSD) following myocardial infarction (MI). The purpose of this study was to assess the effect of age (> or = 70 years) on operative risk and long term survival following repair of an acquired VSD.
  
  
  METHODS
  Between January 1972 and December 1995, 179 patients have undergone repair of acquired VSDs following MI in our unit. There were 118 males and 61 females (age range 43-80 years) of whom 60 were aged 70 years or above.
  
  
  RESULTS
  The overall early mortality was 27%. On univariate analysis risk factors for early death included shorter time from both MI and detection of murmur to operation (P < 0.01, P = 0.04), site of MI (P < 0.01), higher NYHA class (P < 0.01), lower preoperative blood pressure (P < 0.01) and longer cardiopulmonary bypass and cross clamp times (P < 0.01, P = 0.03). Non significant variables included age, sex, concomitant CABG and preoperative renal function. Early mortality was 28.6% (34/119) in patients under 70 and 25.0% (15/60) in those over 70. This difference was not significant. The only significant differences between the age groups were sex distribution (females > males, P < 0.01), in the older group, and shorter time from both MI and detection of murmur to operation (P = 0.04, P = 0.02). Cardiopulmonary bypass was the only statistically significant variable on multivariate analysis (P = 0.01).
  
  
  CONCLUSIONS
  There was no significant difference in early mortality between the two age groups. As shorter times from both MI and detection of murmur to operation adversely affect early mortality, age over 70 years should not be used to determine suitability for surgery.
authors.affiliation: Wessex Cardiothoracic Centre, Southampton General Hospital, UK.
authors.forename: M J
authors.initials: MJ
authors.lastname: Dalrymple-Hay
authors.forename: S M
authors.initials: SM
authors.lastname: Langley
authors.forename: P
authors.initials: P
authors.lastname: Ramesh
authors.forename: R
authors.initials: R
authors.lastname: Pickering
authors.forename: V T
authors.initials: VT
authors.lastname: Tsang
authors.forename: S A
authors.initials: SA
authors.lastname: Livesey
authors.forename: R K
authors.initials: RK
authors.lastname: Lamb
authors.forename: J L
authors.initials: JL
authors.lastname: Monro
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000704:Analysis of Variance; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006345:Heart Septal Defects, Ventricular / Q000209:etiology / Q000401:mortality* / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009203:Myocardial Infarction / Q000150:complications*; D011183:Postoperative Complications / Q000401:mortality; D011788:Quality of Life; D012307:Risk Factors; D015996:Survival Rate; D006113:United Kingdom / Q000453:epidemiology