title: Reversible pulmonary hypertension in neonatal Graves disease.
abstract: Neonatal thyrotoxicosis may occur by transplacental transfer of thyroid stimulating immunoglobins from the mother. Although the clinical manifestations may vary in the new-born period, hyperthyroidism has been associated with several cardiac complications including supraventricular tachycardia, cardiomyopathy and congestive cardiac failure. We report the case of a nine day old baby who presented with severe pulmonary hypertension in association with congestive cardiac failure secondary to neonatal thyrotoxicosis. Treatment of the heart failure and restoration of the thyroid function resulted in complete regression of the pulmonary hypertension. The recognition and reversibility of pulmonary hypertension in neonatal Graves disease has not been previously described.
authors.affiliation: Department of Cardiology, Our Lady's Hospital for Sick Children, Dublin, Ireland.
authors.forename: D
authors.initials: D
authors.lastname: O'Donovan
authors.forename: C
authors.initials: C
authors.lastname: McMahon
authors.forename: C
authors.initials: C
authors.lastname: Costigan
authors.forename: P
authors.initials: P
authors.lastname: Oslizlok
authors.forename: D
authors.initials: D
authors.lastname: Duff
mesh_terms: D013956:Antithyroid Agents / Q000627:therapeutic use; D002231:Carbimazole / Q000627:therapeutic use; D005260:Female; D006111:Graves Disease / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D006333:Heart Failure / Q000188:drug therapy / Q000209:etiology; D006801:Humans; D006976:Hypertension, Pulmonary / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D006980:Hyperthyroidism / Q000150:complications / Q000188:drug therapy; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis*; D011262:Pregnancy Trimester, Second; D011441:Propylthiouracil / Q000627:therapeutic use; D013971:Thyrotoxicosis / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*
chemical_list: D013956:Antithyroid Agents; D011441:Propylthiouracil; D002231:Carbimazole