Islet cell tumour with vacuolated lipid-rich cytoplasm: a new histological variant of islet cell tumour.
OBJECTIVE
A previously unreported clear cell variant of islet cell tumour of the pancreas is described.


RESULTS
By light microscopy, the cytoplasm of the clear cells was finely reticulated and vacuolated. Immuno-histochemical and electron microscopy studies confirmed the endocrine nature of the tumour.


CONCLUSIONS
The clear cell morphology was due to the accumulation of lipid in the cytoplasm.
Ordóñez
N G
NG
University of Texas M.D. Anderson Cancer Centre, Houston 77030, USA.
Silva
E G
EG
D007516:Adenoma, Islet Cell / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure; D000328:Adult; D003593:Cytoplasm / Q000473:pathology; D003594:Cytoplasmic Granules / Q000473:pathology; D006801:Humans; D050356:Lipid Metabolism; D008297:Male; D008854:Microscopy, Electron; D010190:Pancreatic Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure