title: Symmetry-based HIV protease inhibitors containing (S,S) or (R,R) tartaric acid core structure.
abstract: Two series of symmetry-based HIV protease inhibitors containing (S,S) or (R,R) tartaric acid core structure were prepared and tested for inhibitory property against the enzyme. All compounds showed weak antiprotease activity.
authors.affiliation: Department of Pharmaceutical Science, University of Ferrara, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Marastoni
authors.forename: M
authors.initials: M
authors.lastname: Bergonzoni
authors.forename: F
authors.initials: F
authors.lastname: Bortolotti
authors.forename: R
authors.initials: R
authors.lastname: Tomatis
mesh_terms: D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002851:Chromatography, High Pressure Liquid; D016333:HIV Protease / Q000737:chemistry; D017320:HIV Protease Inhibitors / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D008958:Models, Molecular; D008968:Molecular Conformation; D013644:Tartrates / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D017320:HIV Protease Inhibitors; D013644:Tartrates; D016333:HIV Protease