title: Factors influencing stability at the interface between a porous surface and cancellous bone: a finite element analysis of a canine in vivo micromotion experiment.
abstract: Several factors contribute to the success of stable bony ingrowth into the porous coated surfaces of orthopaedic implants used in hip arthroplasty. Despite having good bony apposition, bony ingrowth might not occur if the relative motion between bone and implant is large. Therefore, determining the limiting micromotion value that inhibits stable bony ingrowth is important. From a previous canine in vivo micromotion study performed at our laboratory, this limiting value was found to be 20 microns. Initially, cementless orthopaedic implants are stabilized only by frictional forces at the bone-implant interface. Therefore, other parameters such as the coefficient of friction and the compressive force normal to the interface should be considered as important factors which stabilize the interface along with micromotion. The purpose of this analytical study was to elucidate how the stability at the bone-implant interface is influenced by various factors, namely, motion of the implant, the coefficient of friction, the degree of pres fit, and the modulus of the surrounding cancellous bone in determining the stability of the bone-implant interface. Nonlinear and linear finite element models which simulated the immediate postsurgical condition and the end point of the canine in vivo micromotion experiment, respectively, were used to this end. From the results of the finite element models it was possible to identify the displacement magnitude for which the implant slipped relative to the bone as the motion of the implant was increased incrementally. This was done for combinations of the coefficient of friction, press fit, and Young's modulus of cancellous bone. This was used as an indicator of the limiting implant motion value beyond which bony ingrowth will be inhibited. The stress distribution in the surrounding cancellous bone bed was also obtained from the results of the finite element analyses for different press-fit conditions. The results of the study indicated that under slight press-fit conditions, the implant slipped relative to bone for implant motions as low as 20 microns. For higher degrees of press fit and reasonable values for the coefficient of friction, no slip occurred for implant motions as much as 100 microns. Although higher degrees of press fit were theoretically conducive to better implant stability, the concomitant high stresses in the adjacent cancellous bone will tend to compromise the integrity of the press fit. This was also evident when the results of an analytical model with a lower degree of press fit correlated well with those of the canine in vivo experiment in which a higher press fit was used, suggesting a possibility of achieving a less than desired press fit during the process of implantation. Through this study the importance of factors other than implant motion was emphasized. The results of the study suggest that the limiting value of implant motion that inhibits bone ingrowth might vary with the degree of press fit for reasonable coefficients of friction.
authors.affiliation: Orthopaedic Biomechanics Laboratory, Massachusetts General Hospital, Boston 02114, USA.
authors.forename: B S
authors.initials: BS
authors.lastname: Ramamurti
authors.forename: T E
authors.initials: TE
authors.lastname: Orr
authors.forename: C R
authors.initials: CR
authors.lastname: Bragdon
authors.forename: J D
authors.initials: JD
authors.lastname: Lowenstein
authors.forename: M
authors.initials: M
authors.lastname: Jasty
authors.forename: W H
authors.initials: WH
authors.lastname: Harris
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D001705:Bioprosthesis; D016723:Bone Remodeling; D001842:Bone and Bones; D004285:Dogs; D008954:Models, Biological; D008962:Models, Theoretical
chemical_list: D001672:Biocompatible Materials