title: Feasibility study of a single- and multiple-source near-infrared phase-modulation device for characterizing biologic systems.
abstract: Near-infrared (NIR) spectroscopy is an inexpensive and noninvasive optical method to characterize biologic and physiologic systems. Measurements of oxygen saturation in various organs, cytochrome oxidase concentration, and glucose concentration in tissue are examples of NIR spectroscopy applications. This instrument also has potential for diagnostic imaging by comparing the optical properties of a given point in tissue with those of the surrounding areas, e.g., tumor localization, hematoma detection, or deep vein thrombosis detection. Currently, NIR spectroscopy is available in three modalities: time-resolved spectroscopy (TRS), continuous-wave spectroscopy (CWS), and a phase-modulation device. This paper describes a single-source phase-modulation device and a multiple-source (in- and anti-phased) device and their application to system identification. The phase and intensity information for homogeneous systems is correlated with system and instrumental parameters. Phase and intensity changes resulting from the presence of one and two absorbers are illustrated. The sensitivity of in- and anti-phased phase-modulation devices (phased arrays) is demonstrated. The use of amplitude-modulated phased array for heterogeneity detection is described.
authors.affiliation: Department of Chemical and Biochemical Engineering, University of Maryland Baltimore County 21250, USA.
authors.forename: K A
authors.initials: KA
authors.lastname: Kang
authors.forename: D F
authors.initials: DF
authors.lastname: Bruley
authors.forename: B
authors.initials: B
authors.lastname: Chance
mesh_terms: D003198:Computer Simulation; D003952:Diagnostic Imaging / Q000379:methods; D003576:Electron Transport Complex IV / Q000032:analysis; D004867:Equipment Design; D004869:Equipment Safety; D005240:Feasibility Studies; D005947:Glucose / Q000032:analysis; D006801:Humans; D055095:Optics and Photonics; D010100:Oxygen / Q000032:analysis; D012680:Sensitivity and Specificity; D019265:Spectroscopy, Near-Infrared / Q000295:instrumentation* / Q000379:methods
chemical_list: D003576:Electron Transport Complex IV; D005947:Glucose; D010100:Oxygen