Protein kinase C in central auditory pathways of the rat.
Protein kinase C is an important intracellular signaling molecule. Many of its ten isoforms are highly expressed in brain, and protein kinase C has been implicated in the regulation of the activity of receptors of several major neurotransmitters, including glutamate, acetylcholine, glycine, and gamma-aminobutyric acid. These neurotransmitters and their receptors are present in central auditory pathways, suggesting their role in auditory signal processing. Although they may be important modulators of the function of these neurotransmitter receptors, the distribution of protein kinase C isoforms in central auditory systems has not been well characterized. By using immunocytochemistry with specific antibodies, we studied the distribution of immunoreactivity of four isoforms of protein kinase C, betaI, betaII, gamma, and gamma, in central auditory systems of rat brain. Each of these protein kinase C isoforms was found to have a unique distribution in the auditory brainstem and cortex, supporting a role for these isoforms of protein kinase C in different aspects of auditory sensory processing.
Garcia
M M
MM
Department of Otolaryngology, Tulane University School of Medicine, New Orleans, Louisiana 70112, USA. mgarcia@mailhost.tcs.tulane.edu
Harlan
R E
RE
D000818:Animals; D001303:Auditory Cortex / Q000201:enzymology; D001306:Auditory Pathways / Q000201:enzymology*; D001921:Brain / Q000201:enzymology*; D007150:Immunohistochemistry; D007527:Isoenzymes / Q000378:metabolism*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D011493:Protein Kinase C / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley
D007527:Isoenzymes; D011493:Protein Kinase C