title: Effect of domestically-made levonorgestrel-releasing intrauterine device on the endocrine system and menstruation in monkeys.
abstract: Effect of domestically-made levonorgestrel-releasing intrauterine device (LNG, release rate, 6 micrograms/day) on the endocrine system and menstruation in monkeys was investigated. The results showed that the Estradiol (E2) and progesterone (P) levels were significantly decreased 2 ovulatory cycles after insertion of the devices as compared with those before insertion in 3 monkeys (P > 0.001), suggesting an evident ovulation-suppressing effect. In 1 monkey, the E2 and P levels were the same before and after insertion, and expulsion of device was found in the monkey later. The plasma LNG concentration in 3 animals was 493.69-454.60 pg/ml and plasma LNG was not detected in 1 monkey. The hormone level returned to normal level after removal of the devices.
authors.affiliation: Institute of Family Planning, Tongji Medical University, Wuhan.
authors.forename: C
authors.initials: C
authors.lastname: Wu
authors.forename: W
authors.initials: W
authors.lastname: Xia
authors.forename: X
authors.initials: X
authors.lastname: Wu
authors.forename: R
authors.initials: R
authors.lastname: Li
authors.forename: X
authors.initials: X
authors.lastname: Huang
authors.forename: Y
authors.initials: Y
authors.lastname: Yan
authors.forename: D
authors.initials: D
authors.lastname: Huang
mesh_terms: D000818:Animals; D003271:Contraceptive Agents, Female; D004958:Estradiol / Q000097:blood*; D005260:Female; D007436:Intrauterine Devices, Medicated; D016912:Levonorgestrel / Q000097:blood; D008253:Macaca mulatta; D008598:Menstruation / Q000187:drug effects; D010060:Ovulation / Q000187:drug effects; D011374:Progesterone / Q000097:blood
chemical_list: D003271:Contraceptive Agents, Female; D011374:Progesterone; D004958:Estradiol; D016912:Levonorgestrel