title: [Reflections on the psychobiology of depression].
abstract: Our present understanding of the disorder "depression" undergoes a changing process. Together with the appearance of empirical studies on epidemiology, genetics and therapy, the hypothesis of "endogenous" depression has vanished. The search for "markers" has been replaced by a growing interest for functional connections, thereby generating a variety of possible etiological factors instead of the "depressogenic" synapse. Therapy has been revolutionized by the invention and the empirical proof of new, short-term psychotherapies. However, the lack of a theoretical basis warrants its development as a major endeavor for future research.
authors.affiliation: Klinik für Psychiatrie und Psychotherapie, Christian-Albrechts-Universität zu Kiel.
authors.forename: J
authors.initials: J
authors.lastname: Aldenhoff
mesh_terms: D000928:Antidepressive Agents / Q000627:therapeutic use; D001921:Brain / Q000503:physiopathology*; D003131:Combined Modality Therapy; D003866:Depressive Disorder / Q000175:diagnosis / Q000503:physiopathology* / Q000523:psychology / Q000628:therapy; D006380:Helplessness, Learned; D006801:Humans; D018377:Neurotransmitter Agents / Q000502:physiology*; D011614:Psychotherapy, Brief; D009435:Synaptic Transmission / Q000502:physiology*; D016896:Treatment Outcome
chemical_list: D000928:Antidepressive Agents; D018377:Neurotransmitter Agents