Safety pharmacology of a combination of tinidazole and oxyphenonium bromide.
The effect of a combination of 150 mg tinidazole (CAS 19387-91-8) and 1 mg oxyphenonium bromide (CAS 50-10-2), referred to as the combination, was examined in various animal species to assess its safety. In mice and rats, the combination in the dose range 30-1000 mg/kg p.o. or 250 mg/kg i.p. did not produce behavioural or neurological changes, nor did it influence pentobarbital sleeping time, though, alcohol sleeping time was altered. In anaesthetised dogs, neither blood pressure, ECG, heart rate, respiration or gastrointestinal motility was affected after single intraduodenal administration of the combination 20 and 50 mg/kg or after chronic oral administration of 25 mg/kg daily for 15 days. In isolated organs, viz. perfused rabbit heart, guinea-pig ileum and rat ileum no significant changes were observed following various doses of the combination, compared to tinidazole and oxyphenonium bromide given alone in corresponding concentrations. In conclusion, the pharmacological profile of the aforementioned combination in the dosages employed in mice, rats, guinea-pigs, rabbits and dogs shows that it is safe and well tolerated.
Joseph
T
T
Department of Pharmacology, St. John's Medical College, Bangalore, India.
Venkataraman
V
V
Nagarani
A
A
David
J
J
Bhatt
A
A
Vaidya
A
A
D000818:Animals; D000981:Antiprotozoal Agents / Q000633:toxicity*; D001794:Blood Pressure / Q000187:drug effects; D004285:Dogs; D004338:Drug Combinations; D004562:Electrocardiography / Q000187:drug effects; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects; D006168:Guinea Pigs; D006339:Heart Rate / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D018727:Muscarinic Antagonists / Q000633:toxicity*; D010115:Oxyphenonium / Q000633:toxicity*; D004856:Postural Balance / Q000187:drug effects; D011817:Rabbits; D051381:Rats; D017208:Rats, Wistar; D015656:Respiratory Mechanics / Q000187:drug effects; D014011:Tinidazole / Q000633:toxicity*
D000981:Antiprotozoal Agents; D004338:Drug Combinations; D018727:Muscarinic Antagonists; D014011:Tinidazole; D010115:Oxyphenonium