Genetic factors in human hypertension.
The advancement of molecular biomedical techniques has allowed solutions to the problem of finding a genetic linkage to hypertension. This is now being approached by limiting study to a select number of genetic factors possibly influencing a particular physiologic dysfunction or structural defect. Analysis of chromosomal abnormalities or regions bearing a particular mutation have been greatly influenced by the ability to produce artificial chromosomes or to identify closely linked markers. Rapid accumulation of knowledge of the genetic map has led to a number of these gene/disease linkages. Perhaps the unraveling of some of the polygenic influences in hypertension may lead to even better treatment protocols to minimize the disease complications of elevated blood pressure.
Miura
D S
DS
Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, USA.
D000483:Alleles; D000808:Angiotensinogen / Q000235:genetics; D001794:Blood Pressure / Q000235:genetics; D008040:Genetic Linkage; D006801:Humans; D006929:Hyperaldosteronism / Q000235:genetics; D006973:Hypertension / Q000235:genetics* / Q000503:physiopathology; D009154:Mutation; D007703:Peptidyl-Dipeptidase A / Q000235:genetics
D000808:Angiotensinogen; D007703:Peptidyl-Dipeptidase A