title: A phosphorylation cascade in the basal ganglia of the mammalian brain: regulation by the D-1 dopamine receptor. A mathematical model of known biochemical reactions.
abstract: Stimulation of the dopamine D-1 receptor in the corpus striatum initiates a cascade of biochemical events. These events include: activation of adenylate cyclase, stimulation of cAMP-dependent protein kinase, protein phosphorylation and inhibition of phosphoprotein phosphotase-1. This article presents and discusses a mathematical model of these biochemical events (and their dependence upon the concentration of cytosolic calcium). According to this model, the activity of calcineurin (which is regulated by the concentration of cytosolic calcium ions) counterbalances the activity of the "D-1 cascade". The combined activity of the "D-1 cascade" and calcineurin can regulate the activity of calcium- and calmodulin-dependent protein kinase II.
authors.affiliation: Research Biochemicals International, Natick, MA, USA.
authors.forename: J W
authors.initials: JW
authors.lastname: Kebabian
mesh_terms: D000262:Adenylyl Cyclases / Q000378:metabolism; D000818:Animals; D001479:Basal Ganglia / Q000502:physiology*; D001921:Brain / Q000502:physiology*; D054732:Calcium-Calmodulin-Dependent Protein Kinase Type 2; D017871:Calcium-Calmodulin-Dependent Protein Kinases / Q000378:metabolism; D017868:Cyclic AMP-Dependent Protein Kinases / Q000378:metabolism; D008322:Mammals; D008959:Models, Neurological; D008962:Models, Theoretical; D009474:Neurons / Q000502:physiology; D010749:Phosphoprotein Phosphatases / Q000378:metabolism; D010727:Phosphoric Diester Hydrolases / Q000378:metabolism; D010766:Phosphorylation; D017447:Receptors, Dopamine D1 / Q000502:physiology*; D015398:Signal Transduction
chemical_list: D017447:Receptors, Dopamine D1; D017868:Cyclic AMP-Dependent Protein Kinases; D054732:Calcium-Calmodulin-Dependent Protein Kinase Type 2; D017871:Calcium-Calmodulin-Dependent Protein Kinases; D010749:Phosphoprotein Phosphatases; D010727:Phosphoric Diester Hydrolases; D000262:Adenylyl Cyclases