Erythrocyte carbonic anhydrase activity in smokers and in diabetic patients.
Carbonic anhydrase activity was measured in lyzed erythrocytes from smoking and non-smoking young men as well as from diabetic and healthy young women. Enzyme activity was determined by a changing-pH-assay, using a stirred reaction vessel and glass pH electrode. CAA was lower in smokers than in non-smokers. Furthermore, it was lower in diabetics than in nondiabetic controls. We conclude that cigarette smoking as well as diabetes mellitus may reduce erythrocyte carbonic anhydrase activity.
Abel
P
P
Institute of Physiology, Ernst-Moritz-Arndt-University Greifswald, Germany.
Wussow
S
S
Blücher
H
H
Gros
G
G
Rettig
R
R
Honig
A
A
D000328:Adult; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000201:enzymology*; D004563:Electrochemistry / Q000379:methods; D004912:Erythrocytes / Q000201:enzymology*; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D008297:Male; D012016:Reference Values; D012907:Smoking / Q000097:blood / Q000378:metabolism*; D013482:Superoxide Dismutase / Q000097:blood*
D013482:Superoxide Dismutase