title: Acyclic glycosidopyrroles analogues of ganciclovir: synthesis and biological activity.
abstract: Acyclic glycosidopyrroles of type 3 were synthetized in good overall yields, according to the Scheme. When evaluated for antiviral activity against DNA and RNA viruses, only compound in which R1 = R2 = Ph, R3 = NH2 was found to inhibit the HIV-1 replication at concentrations that were not cytotoxic for MT-4 cells.
authors.affiliation: Istituto Farmacochimico, Università degli Studi, Palermo, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Diana
authors.forename: P
authors.initials: P
authors.lastname: Barraja
authors.forename: A M
authors.initials: AM
authors.lastname: Almerico
authors.forename: G
authors.initials: G
authors.lastname: Dattolo
authors.forename: F
authors.initials: F
authors.lastname: Mingoia
authors.forename: A G
authors.initials: AG
authors.lastname: Loi
authors.forename: E
authors.initials: E
authors.lastname: Congeddu
authors.forename: C
authors.initials: C
authors.lastname: Musiu
authors.forename: M
authors.initials: M
authors.lastname: Putzolu
authors.forename: P
authors.initials: P
authors.lastname: La Colla
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D015774:Ganciclovir / Q000031:analogs & derivatives*
chemical_list: D000998:Antiviral Agents; D015774:Ganciclovir