[The injury of liver sinusoidal endothelial cells in a rat's isolated liver perfusion (ILP) model for regional chemotherapy].
To observe the pathological changes of liver sinusoidal endothelial cells, the regional perfusion with different dosage of 5-FU was performed by using modified rat's model of ILP. The results demonstrated that ILP with over maximum tolerence dosage of (MTD) 5-FU resulted in irreversible damage of liver and endothelial cells. The endothelial cells were more fragile than liver cells. The changes of TXA2 and PGI2 balance play an important role in the process of damage of endothelial cells.
Xing
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Affiliated Hospital, Binzhou Medical College.
Xia
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D015121:6-Ketoprostaglandin F1 alpha / Q000097:blood; D000818:Animals; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage / Q000009:adverse effects*; D010478:Chemotherapy, Cancer, Regional Perfusion; D004727:Endothelium / Q000187:drug effects / Q000473:pathology; D005472:Fluorouracil / Q000008:administration & dosage / Q000009:adverse effects*; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013929:Thromboxane B2 / Q000097:blood
D000964:Antimetabolites, Antineoplastic; D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha; D005472:Fluorouracil