title: Dendritic cells as immunogens for human CTL responses.
abstract: The cellular requirements for generating potent human CD8+ CTLs to influenza A virus in vitro have been defined. Furthermore, we have developed improved methods for generating large numbers of DCs from non-proliferating progenitors. These developments have enabled the design of new strategies to elicit CTLs in vivo. For example, together with IL-12, antigen-pulsed DCs may be a useful approach for boosting CTL responses against infectious agents and malignancies. Our results also reopen the potential use of inactivated virus preparations as immunogens for CTL responses.
authors.affiliation: Rockefeller University, New York 10021, USA.
authors.forename: A
authors.initials: A
authors.lastname: Bender
authors.forename: M
authors.initials: M
authors.lastname: Sapp
authors.forename: M
authors.initials: M
authors.lastname: Feldman
authors.forename: A
authors.initials: A
authors.lastname: Reddy
authors.forename: R
authors.initials: R
authors.lastname: Seder
authors.forename: G
authors.initials: G
authors.lastname: Schuler
authors.forename: R M
authors.initials: RM
authors.lastname: Steinman
authors.forename: N
authors.initials: N
authors.lastname: Bhardwaj
mesh_terms: D001773:Blood Cells / Q000166:cytology / Q000276:immunology; D002450:Cell Communication; D002454:Cell Differentiation; D003713:Dendritic Cells / Q000166:cytology / Q000276:immunology*; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000276:immunology; D006801:Humans; D066298:In Vitro Techniques; D009980:Influenza A virus / Q000276:immunology; D018664:Interleukin-12 / Q000494:pharmacology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D014611:Vaccination
chemical_list: D018664:Interleukin-12