title: Relationship of necrosis to organ failure in severe acute pancreatitis.
abstract: OBJECTIVE
  Pancreatic necrosis and organ failure are principal determinants of severity in acute pancreatitis. The purpose of this study was to determine the relationship of necrosis to organ failure in severe acute pancreatitis.
  
  
  METHODS
  Patients with necrotizing pancreatitis from May 1992 to January 1996 were retrospectively studied. Pancreatic necrosis was identified by characteristic findings on dynamic contrast-enhanced computerized tomography scan and infected necrosis by computerized tomography-guided percutaneous aspiration. Organ dysfunction was defined in accordance with the Atlanta symposium.
  
  
  RESULTS
  Organ failure was present in only 26 of 51 patients (51%). There was no difference in the prevalence of organ failure in infected necrosis compared with sterile necrosis (approximately 50% in both groups). Patients with increased amounts of necrosis did not have an increased prevalence of organ failure or infected necrosis compared with those with lesser amounts of necrosis. Patients with organ failure had an increased morbidity and mortality compared with those without organ failure.
  
  
  CONCLUSIONS
  Organ failure occurred in only one half of patients with necrotizing pancreatitis. Because organ failure increases the severity of illness, studies of patients with necrotizing pancreatitis must stratify for organ failure to facilitate interpretation of results.
authors.affiliation: Center for Pancreatic Disease, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: S
authors.initials: S
authors.lastname: Tenner
authors.forename: G
authors.initials: G
authors.lastname: Sica
authors.forename: M
authors.initials: M
authors.lastname: Hughes
authors.forename: E
authors.initials: E
authors.lastname: Noordhoek
authors.forename: S
authors.initials: S
authors.lastname: Feng
authors.forename: M
authors.initials: M
authors.lastname: Zinner
authors.forename: P A
authors.initials: PA
authors.lastname: Banks
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007239:Infections / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009017:Morbidity; D009102:Multiple Organ Failure / Q000453:epidemiology / Q000209:etiology* / Q000401:mortality; D019283:Pancreatitis, Acute Necrotizing / Q000150:complications* / Q000188:drug therapy / Q000382:microbiology; D015995:Prevalence
chemical_list: D000900:Anti-Bacterial Agents