Acyclic glycosidopyrroles analogues of ganciclovir: synthesis and biological activity.
Acyclic glycosidopyrroles of type 3 were synthetized in good overall yields, according to the Scheme. When evaluated for antiviral activity against DNA and RNA viruses, only compound in which R1 = R2 = Ph, R3 = NH2 was found to inhibit the HIV-1 replication at concentrations that were not cytotoxic for MT-4 cells.
Diana
P
P
Istituto Farmacochimico, Università degli Studi, Palermo, Italy.
Barraja
P
P
Almerico
A M
AM
Dattolo
G
G
Mingoia
F
F
Loi
A G
AG
Congeddu
E
E
Musiu
C
C
Putzolu
M
M
La Colla
P
P
D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D015774:Ganciclovir / Q000031:analogs & derivatives*
D000998:Antiviral Agents; D015774:Ganciclovir