title: The road less travelled: taming phosphatases.
abstract: Phosphatases are important in signal transduction, bacterial pathogenesis and several human diseases. So far, however, it is their opposite numbers, the kinases, that have received more attention from chemists. Recent progress in inhibitor development offers hope that new probes of cellular processes, and perhaps novel therapeutic agents, may soon become available.
authors.affiliation: Department of Chemistry, Indiana University, Bloomington 47405, USA. twidlanski@indiana.edu
authors.forename: T S
authors.initials: TS
authors.lastname: Widlanski
authors.forename: J K
authors.initials: JK
authors.lastname: Myers
authors.forename: B
authors.initials: B
authors.lastname: Stec
authors.forename: K M
authors.initials: KM
authors.lastname: Holtz
authors.forename: E R
authors.initials: ER
authors.lastname: Kantrowitz
mesh_terms: D000345:Affinity Labels; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology; D006801:Humans; D010744:Phosphoric Monoester Hydrolases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D000345:Affinity Labels; D004791:Enzyme Inhibitors; D010744:Phosphoric Monoester Hydrolases