title: Heart valve operation in acromegaly.
abstract: BACKGROUND
  Intractable congestive heart failure is known as a serious complication of acromegaly, but valvular heart disease rarely occurs in acromegalic patients. We experienced 5 surgical cases of valvular heart disease associated with acromegaly. We describe the features of those cases in this report.
  
  
  METHODS
  The patient characteristics and operative and pathologic findings were retrospectively studied.
  
  
  RESULTS
  There were 4 men and 1 women. Age at operation was 59 +/- 5.5 years. Cardiac lesions consisted of 1 case of aortic regurgitation associated with mitral regurgitation, 1 of aortic regurgitation, and 3 of mitral regurgitation. Operative procedures consisted of 1 double valve replacement (aortic and mitral valve replacement), 1 aortic valve replacement, and 3 mitral valve replacements. The causes of aortic valvular regurgitation were aortic valvular degeneration and aortic annular dilatation. The causes of mitral regurgitation were chordal rupture and mitral valvular degeneration. Histopathologic examination of the excised valves showed mucopolysaccharide deposits and myxomatous degeneration of the leaflets. The myocardium showed fibrosis of interstitial spaces and endocardium, and disarrangement of muscle fibers.
  
  
  CONCLUSIONS
  We report 5 successful surgical cases of valvular heart disease associated with acromegaly. Earlier operation is recommended for such cases because of acromegalic cardiomyopathy.
authors.affiliation: Department of Cardiovascular Surgery, Heart Institute of Japan, Tokyo Women's Medical College, Japan.
authors.forename: G
authors.initials: G
authors.lastname: Ohtsuka
authors.forename: S
authors.initials: S
authors.lastname: Aomi
authors.forename: H
authors.initials: H
authors.lastname: Koyanagi
authors.forename: H
authors.initials: H
authors.lastname: Tsukui
authors.forename: Y
authors.initials: Y
authors.lastname: Tomizawa
authors.forename: A
authors.initials: A
authors.lastname: Hashimoto
authors.forename: Y
authors.initials: Y
authors.lastname: Sakomura
mesh_terms: D000172:Acromegaly / Q000150:complications*; D000368:Aged; D001021:Aortic Valve / Q000473:pathology; D001022:Aortic Valve Insufficiency / Q000150:complications / Q000473:pathology / Q000601:surgery*; D005260:Female; D006333:Heart Failure / Q000150:complications / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D008943:Mitral Valve / Q000473:pathology; D008944:Mitral Valve Insufficiency / Q000150:complications / Q000473:pathology / Q000601:surgery*; D009206:Myocardium / Q000473:pathology; D012189:Retrospective Studies