title: Analysis of the immunoglobulin heavy-chain gene rearrangement providing molecular evidence of second lymphoma in a patient in apparent relapse after autotransplantation.
abstract: Development of a second lymphoma after autotransplantation is an unusual event. Its real incidence, however, could be underestimated, since histologic and immunophenotyping techniques are often unable to distinguish it from a relapse. We report a lymphoma patient in apparent relapse after 42 months of molecular remission achieved by autotransplantation. Sequencing analysis of the immunoglobulin heavy-chain genes showed that the rearrangement of variable, diversity and joining segments had changed between diagnosis and relapse and suggested that a second lymphoma had developed.
authors.affiliation: Dipartimento di Medicina ed Oncologia Sperimentale, Azienda Ospedaliera S Giovanni Battista, Torino, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Campana
authors.forename: P
authors.initials: P
authors.lastname: Corradini
authors.forename: M
authors.initials: M
authors.lastname: Astolfi
authors.forename: M
authors.initials: M
authors.lastname: Ladetto
authors.forename: F
authors.initials: F
authors.lastname: Cinque
authors.forename: D
authors.initials: D
authors.lastname: Novero
authors.forename: C
authors.initials: C
authors.lastname: Tarella
authors.forename: A
authors.initials: A
authors.lastname: Pileri
mesh_terms: D000328:Adult; D001483:Base Sequence; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D002051:Burkitt Lymphoma / Q000175:diagnosis*; D015321:Gene Rearrangement; D005803:Genes, Immunoglobulin; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics*; D008224:Lymphoma, Follicular / Q000628:therapy*; D008297:Male; D008969:Molecular Sequence Data; D016609:Neoplasms, Second Primary / Q000175:diagnosis*; D012008:Recurrence; D014182:Transplantation, Autologous
chemical_list: D007143:Immunoglobulin Heavy Chains