Clinicopathological profile of subacute hepatic failure.
Twenty two patients of subacute hepatic failure (SAHF), diagnosed when jaundice progressed for more than 8 weeks with appearance of ascites, with or without encephalopathy, along with biochemical evidence of hepatocellular damage, were studied. The male and female ratio was 4.5:1 and majority (45.4%) of cases were between the age group of 41-50. The mean biochemical values were: S.bilirubin; 9.2 +/- 3.8 mg/dl SGOT; 94.4 +/- 25.0 I.U./lit., SGPT; 107.8 +/- 32.7 I.U./lit., S.Protein; 5.2 +/- 3.5 secs. Ascitic fluid analysis showed transudate in 16 (72.7%) and exudate in 6 (27.2%) patients. Bacterial peritonitis was found in 5 (22.7%) patients. Liver biopsy showed bridging and submassive necrosis. The complications developed in the hospital were: renal failure (36.3%), infection (27.2%), G.I. bleeding (18.1%) and encephalopathy (13.6%). The mortality was (86.3%). Out of 3 (13.6%) patients who survived, only two recovered completely and one had biochemical evidence of hepatocellular necrosis after 6 months of follow up.
Mohapatra
M K
MK
M.K.C.G. Medical College, Berhampur, Ganjam, Orissa.
Samal
M M
MM
Padhiary
K N
KN
Dash
P C
PC
Sahoo
G N
GN
Patnaik
B C
BC
D000208:Acute Disease; D000328:Adult; D001201:Ascites / Q000209:etiology; D001706:Biopsy; D003937:Diagnosis, Differential; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006501:Hepatic Encephalopathy / Q000209:etiology; D006801:Humans; D007565:Jaundice / Q000209:etiology; D008099:Liver / Q000473:pathology*; D017093:Liver Failure / Q000150:complications / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D015996:Survival Rate