[The mechanisms of ET-1-induced lung edema].
OBJECTIVE
To investigate the machanisms of ET-1-induced lung edema.


METHODS
Different doses of ET-1 were added to isolate rat lungs perfused by Ringer's solution containing albumin to explore the mechanisms of ET-1 induced pulmonary edema. The lung weight gain, pulmonary vascular permeability to water (Wf) and albumin (Ps) were observed.


RESULTS
It was found that low dose ET-1 increased lung weight gain, pulmonary artery pressure, pulmonary capillary pressure, pulmonary vascular post-resistance and total resistance, but no significant changes of vascular permeability were observed.


CONCLUSIONS
The mechanisms of lung edema induced by ET-1 are different. Low dose ET-1 may induce lung edema by increasing pulmonary vascular permeability while large dose ET-1 by increasing pulmonary vascular pressure.
Hu
N
N
Department of Anesthesiology, Changhai Hospital, Second Military Medical University, Shanghai.
Chen
S
S
Yu
B
B
D000818:Animals; D002199:Capillary Permeability; D019332:Endothelin-1; D066298:In Vitro Techniques; D008168:Lung / Q000098:blood supply; D008297:Male; D011654:Pulmonary Edema / Q000139:chemically induced* / Q000503:physiopathology; D051381:Rats; D017207:Rats, Sprague-Dawley; D014655:Vascular Resistance
D019332:Endothelin-1