title: Electrical impedance of the cochlear implant lubricants hyaluronic acid, oxycellulose, and glycerin.
abstract: Hyaluronic acid (Healon), oxycellulose (hydroxypropyl methylcellulose), and glycerin are lubricants used in cochlear implant surgery for atraumatic deep insertion of the electrode array into the scala tympani. The electrical impedances of these three lubricants were measured to assess possible effects on intraoperative evoked response measurements, such as the electrically evoked stapedius reflex and auditory brain stem response. The impedances of hyaluronic acid, oxycellulose, and saline were very similar and independent of frequency (20 Hz to 1 MHz). Glycerin had an excessively high impedance at low frequencies. A film of hyaluronic acid or oxycellulose around the electrode array immersed in saline did not have any measurable effect on the impedance; a film of glycerin resulted in a strongly reactive polarized layer. However, neither the far-field current spread nor the impedance between stimulated electrodes was affected by any of the lubricants applied as a thin film. This suggests that none of these lubricants affect intraoperative responses, when applied as a thin film.
authors.affiliation: Department of Otorhinolaryngology, University Hospital Nijmegen, The Netherlands.
authors.forename: L H
authors.initials: LH
authors.lastname: Mens
authors.forename: T F
authors.initials: TF
authors.lastname: Oostendorp
authors.forename: G C
authors.initials: GC
authors.lastname: Hombergen
authors.forename: P
authors.initials: P
authors.lastname: den Broek
mesh_terms: D003054:Cochlear Implants; D017097:Electric Impedance; D005990:Glycerol; D006820:Hyaluronic Acid; D065347:Hypromellose Derivatives; D008153:Lubrication; D008747:Methylcellulose / Q000031:analogs & derivatives* / Q000494:pharmacology
chemical_list: D065347:Hypromellose Derivatives; D006820:Hyaluronic Acid; D008747:Methylcellulose; D005990:Glycerol