Coenzyme Q changes in liver and plasma in the rat after partial hepatectomy.
The levels of coenzyme Q were determined in blood plasma and regenerating liver mitochondria of hepatectomized rats, using as controls either sham-operated or non-operated animals. Mitochondrial CoQ9 content increased in sham-operated rats, whereas it was significantly lower in hepatectomized with respect to non-operated animals. Plasma CoQ9 levels decreased dramatically in hepatectomized animals, but increased strongly in sham-operated in comparison with non-operated rats. The data suggest the possibility of a rate-limiting step in CoQ biosynthesis in hepatectomized animals.
Castelluccio
C
C
Department of Biochemistry G. Moruzzi, University of Bologna, Italy.
Formiggini
G
G
Merlo Pich
M
M
Genova
M L
ML
Bovina
C
C
Marchetti
M
M
Lenaz
G
G
D000818:Animals; D006498:Hepatectomy; D008074:Lipoproteins / Q000378:metabolism; D008115:Liver Regeneration; D008297:Male; D008930:Mitochondria, Liver / Q000378:metabolism*; D011184:Postoperative Period; D051381:Rats; D017208:Rats, Wistar; D014451:Ubiquinone / Q000097:blood / Q000378:metabolism*
D008074:Lipoproteins; D014451:Ubiquinone; C030571:ubiquinone 9