[Measurement of relative plasma volume and plasma refilling rate during ultrafiltration of hemodialysis by measuring apparatus of plasma colloidal osmotic pressure].
BACKGROUND
The objective of this study is the prevention of unexpected hypotension during hemodialysis caused by unsuitable filtration rate.


METHODS
The plasma colloidal osmotic pressure (COP) was measured continuously during ultra-filtration, and relative plasma volume (%PV) and plasma refilling rate (PRR) were calculated during 12 ECUMs and one dialysis on twelve patients in early stage of chronic renal failure. Values of %PV and PRR calculated from COP were drawn in graphic curves, and analysed to obtain characteristic pattern. Minimum value of %PV (%PV min), maximum value of PRR (PRRmax) and time for PRR to decrease to 95% (95% PVt) on the curves were documented simultaneously.


RESULTS
At the initial stage of %PV curve, obvious fall was observed on 6 of 13 estimation (initial fall of %PV). On the contrary at the initial stage of PRR curve, obvious rise was observed on 5 estimation (initial rise of PRR). A close relationship was indicated between the two phenomenons. In 6 cases with initial fall of %PV and in 5 cases with initial rise of PRR body weight, PRRmax and 95%PVt were lower than another cases without it. The ultra-infiltration velocity was estimated to be relatively high in these groups. In these 8 cases, filtrated water volume was judged as adequate clinically. In 4 of 5 cases without final fall of PRR, it was judged as inadequate and needed to evacuate more 0.9 to 3.0 kg (average of 1.8 +/- 1.07) of water from the patients.


CONCLUSIONS
From the above, we concluded that our method is useful for deciding suitable velocity of ultrafiltration and dry weight in hemodialysis therapy.)
Abe
R
R
Fuji Hospital.
Wakabayashi
T
T
Takeuchi
H
H
D000328:Adult; D000368:Aged; D003928:Diabetic Nephropathies / Q000503:physiopathology / Q000628:therapy; D005260:Female; D005921:Glomerulonephritis / Q000503:physiopathology / Q000628:therapy; D006801:Humans; D007022:Hypotension / Q000517:prevention & control*; D008297:Male; D008875:Middle Aged; D009997:Osmotic Pressure; D010953:Plasma Volume; D006435:Renal Dialysis; D014462:Ultrafiltration