Effect of domestically-made levonorgestrel-releasing intrauterine device on the endocrine system and menstruation in monkeys.
Effect of domestically-made levonorgestrel-releasing intrauterine device (LNG, release rate, 6 micrograms/day) on the endocrine system and menstruation in monkeys was investigated. The results showed that the Estradiol (E2) and progesterone (P) levels were significantly decreased 2 ovulatory cycles after insertion of the devices as compared with those before insertion in 3 monkeys (P > 0.001), suggesting an evident ovulation-suppressing effect. In 1 monkey, the E2 and P levels were the same before and after insertion, and expulsion of device was found in the monkey later. The plasma LNG concentration in 3 animals was 493.69-454.60 pg/ml and plasma LNG was not detected in 1 monkey. The hormone level returned to normal level after removal of the devices.
Wu
C
C
Institute of Family Planning, Tongji Medical University, Wuhan.
Xia
W
W
Wu
X
X
Li
R
R
Huang
X
X
Yan
Y
Y
Huang
D
D
D000818:Animals; D003271:Contraceptive Agents, Female; D004958:Estradiol / Q000097:blood*; D005260:Female; D007436:Intrauterine Devices, Medicated; D016912:Levonorgestrel / Q000097:blood; D008253:Macaca mulatta; D008598:Menstruation / Q000187:drug effects; D010060:Ovulation / Q000187:drug effects; D011374:Progesterone / Q000097:blood
D003271:Contraceptive Agents, Female; D011374:Progesterone; D004958:Estradiol; D016912:Levonorgestrel