Scaffolds for engineering novel binding sites in proteins.
The combination of combinational protein chemistry and powerful selection techniques has resulted in the development of novel protein ligands based on the randomization of surface residues of a parental protein which is used as a scaffold. Such binding proteins, selected from libraries via specific binding towards a given target ligand, have the potential to replace natural antibodies in various biotechnological applications.
Nygren
P A
PA
Department of Biochemistry and Biotechnology, Royal Institute of Technology (KTH), Stockholm, Sweden. perake@biochem.kth.se
Uhlén
M
M
D001665:Binding Sites; D008024:Ligands; D019151:Peptide Library; D015202:Protein Engineering / Q000379:methods*; D011506:Proteins / Q000737:chemistry*
D008024:Ligands; D019151:Peptide Library; D011506:Proteins