title: Progesterone receptor participates in the stimulatory effect of LHRH, prostaglandin E2, and cyclic AMP on lordosis and proceptive behaviours in rats.
abstract: We explored the effect of the antiprogestin RU486 on the estrous behaviour (lordosis and proceptivity) induced in sexually experienced ovariectomized oestrogen primed rats by: 5 microg luteinizing hormone-releasing hormone (LHRH), 100 microg prostaglandin E2 (PGE2), or 2 mg dibutyryl cyclic AMP (db cAMP). Pretreatment with 5 mg RU 486 (but not with vehicle) 60 min before the injection of the above-mentioned agents significantly decreased both lordosis and proceptive behaviours normally induced by such agents. Results suggest that the estrus-inducing action of LHRH, PGE2 and db cAMP occurs through the activation of the progesterone receptor.
authors.affiliation: Centro de Investigación en Reproducciön Animal, CINVESTAV-UniversidadAutónoma de Tlaxcala, Mexico.
authors.forename: C
authors.initials: C
authors.lastname: Beyer
authors.forename: O
authors.initials: O
authors.lastname: González-Flores
authors.forename: G
authors.initials: G
authors.lastname: González-Mariscal
mesh_terms: D000818:Animals; D003994:Bucladesine / Q000494:pharmacology; D000242:Cyclic AMP / Q000494:pharmacology*; D015232:Dinoprostone / Q000494:pharmacology*; D004958:Estradiol / Q000494:pharmacology; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000494:pharmacology*; D006727:Hormone Antagonists / Q000494:pharmacology; D015735:Mifepristone / Q000494:pharmacology; D010052:Ovariectomy; D011187:Posture; D011374:Progesterone / Q000037:antagonists & inhibitors; D051381:Rats; D017208:Rats, Wistar; D011980:Receptors, Progesterone / Q000502:physiology*; D012726:Sexual Behavior, Animal / Q000187:drug effects* / Q000502:physiology
chemical_list: D006727:Hormone Antagonists; D011980:Receptors, Progesterone; D015735:Mifepristone; D007987:Gonadotropin-Releasing Hormone; D011374:Progesterone; D004958:Estradiol; D003994:Bucladesine; D000242:Cyclic AMP; D015232:Dinoprostone