Epithelial differentiation in Drosophila.
Our understanding of epithelial development in Drosophila has been greatly improved in recent years. Two key regulators of epithelial polarity, Crumbs and DE-cadherin, have been studied at the genetic and molecular levels and a number of additional genes are being analyzed that contribute to the differentiation of epithelial cell structure. Epithelial architecture has a profound influence on morphogenetic movements, patterning and cell-type determination. The combination of embryological and genetic/molecular tools in Drosophila will help us to elucidate the complex events that determine epithelial cell structure and how they relate to morphogenesis and other developmental processes.
Tepass
U
U
Department of Zoology, University of Toronto, Ontario, Canada. utepass@zoo.utoronto.ca
D000818:Animals; D001756:Blastoderm / Q000166:cytology / Q000502:physiology; D015820:Cadherins / Q000502:physiology; D002450:Cell Communication; D002454:Cell Differentiation; D016764:Cell Polarity; D004064:Digestive System / Q000196:embryology / Q000254:growth & development; D004330:Drosophila / Q000196:embryology / Q000235:genetics / Q000254:growth & development*; D004847:Epithelial Cells; D004848:Epithelium / Q000254:growth & development; D008565:Membrane Proteins / Q000502:physiology; D008954:Models, Biological; D009024:Morphogenesis
D015820:Cadherins; D008565:Membrane Proteins