[The immuno-pathological damage of placenta and its types in pregnancy induced hypertension].
OBJECTIVE
To study the immuno-pathological damage to placenta and its types in pregnancy induced hypertension (PIH).


METHODS
Using immunohistochemical technique (PAP method), authors studied the expression and localization of IgG, IgE, C3, C4, 5-HT on the villous vessels wall in PIH patients (n = 22) and normal pregnant women (n = 10), and observed the pathological changes of placenta with mast cell and connective tissue stain.


RESULTS
The immunostaining of IgG, IgE, C3, C4, and 5-HT were seen in the wall of villous vessels in PIH patients, the strong positive rate were 100%, 90%, 100%, 100%, 90% in severe PIH patients respectively, accompanied by aggregation of mast cells and lesions of villi and villous arterioles.


CONCLUSIONS
The immunological compound reaction and types 1, N of anaphylactic reactions took place in the placenta of PIH patients. It showed that the immunological factors were closely related to PIH.
Chen
H
H
Tongji Hospital, Tongji Medical University, Wuhan.
Huang
Y
Y
Ma
T
T
D000936:Antigen-Antibody Complex / Q000378:metabolism; D003176:Complement C3 / Q000378:metabolism; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000378:metabolism; D007074:Immunoglobulin G / Q000378:metabolism*; D010920:Placenta / Q000276:immunology / Q000473:pathology*; D011225:Pre-Eclampsia / Q000276:immunology* / Q000473:pathology*; D011247:Pregnancy; D012701:Serotonin / Q000378:metabolism
D000936:Antigen-Antibody Complex; D003176:Complement C3; D007074:Immunoglobulin G; D012701:Serotonin; D007073:Immunoglobulin E