Sooty foot, a novel mouse mutation that affects the pigmentation of exposed skin, but not hair, maps to chromosome 2.
We have characterized a novel recessive mouse mutation, named sooty foot, that increases the pigmentation of the exposed skin on the foot pads, the genital region, around the snout and muzzle, the ears, and the tail. By contrast, the pigmentation of the hair is unaffected. We have localized the mutation to Chromosome 2 by polymerase chain reaction (PCR) amplification of simple sequence repeats from pooled DNA from backcross progeny. In an extended backcross we have generated a detailed map of the region around sooty foot.
Budd
P S
PS
Medical Research Council Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, UK.
Antoniou
J
J
Mellor
A L
AL
Jackson
I J
IJ
D054366:Agouti Signaling Protein; D000818:Animals; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D005528:Foot; D005808:Genes, Recessive; D008040:Genetic Linkage; D005819:Genetic Markers; D006680:HLA Antigens / Q000235:genetics; D059951:HLA-G Antigens; D006200:Hair Color / Q000235:genetics; D015395:Histocompatibility Antigens Class I / Q000235:genetics; D006720:Homozygote; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008817:Mice, Mutant Strains; D008822:Mice, Transgenic; D008853:Microscopy; D009154:Mutation; D010641:Phenotype; D010858:Pigmentation / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011506:Proteins / Q000235:genetics; D012880:Skin Pigmentation / Q000235:genetics; D013623:Tail
D054366:Agouti Signaling Protein; D005819:Genetic Markers; D006680:HLA Antigens; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I; D036341:Intercellular Signaling Peptides and Proteins; D011506:Proteins