[Controlled hyperstimulation in intra-uterine inseminations: hMG-hCG protocol (204 cycles)].
OBJECTIVE
to evaluate the results of superovulation, protocol hMG-hCG, associated to IUI for treatment of infertility.


METHODS
this prospective study, includes 77 couples who underwent 204 consecutive cycles of homologous IUI. The same protocol was applied for all the couples. hMG was administrated from cycle days 2 to 5 (3 then 2 ampuls per day). Patients were monitored daily, by evaluation of serum oestradiol. Insemination was done 36 to 38 hours after hCG injection.


RESULTS
2.6 cycles were done per couple. We observed 16.2% pregnancy per cycle. The best results were obtained in female indications, in the first cycle, with more than 500,000 spermatozoide and with a level of E2 between 500 and 1500 pg/ml. Multiple pregnancy was observed in 18.2%.


CONCLUSIONS
controlled ovarian stimulation should be associated to all IUI.
Abboud
P
P
Service de Gynécologie-Obstétrique, CHU de Reims, Hôpital Maison Blanche, Reims.
Delépine
B
B
Pigeon
F
F
Bednarczyk
L
L
Quéreux
C
C
D000328:Adult; D006063:Chorionic Gonadotropin / Q000627:therapeutic use*; D002985:Clinical Protocols; D016903:Drug Monitoring; D004359:Drug Therapy, Combination; D004958:Estradiol / Q000097:blood; D005260:Female; D005300:Fertility Agents, Female / Q000627:therapeutic use*; D006801:Humans; D007317:Insemination, Artificial, Homologous / Q000379:methods*; D008596:Menotropins / Q000627:therapeutic use*; D008875:Middle Aged; D010062:Ovulation Induction / Q000379:methods*; D011247:Pregnancy; D011256:Pregnancy Outcome; D011272:Pregnancy, Multiple; D011446:Prospective Studies
D006063:Chorionic Gonadotropin; D005300:Fertility Agents, Female; D004958:Estradiol; D008596:Menotropins