title: Natural cilia-associated respiratory bacillus infection in rabbits used for elaboration of hyperimmune serum against Mycoplasma sp.
abstract: Cilia-associated respiratory (CAR) bacillus was identified in lung lesions of rabbits used for elaboration of hyperimmune serum against Mycoplasma mycoides ssp. capri (Mmc). Numerous Warthin Starry (WS) positive filamentous bacteria aligned perpendicularly to the surface of bronchial epithelial lining were observed. Immunoperoxidase staining of these bacteria was detected using a serum anti-rabbit CAR bacillus. Ultrastructural morphology corresponds to that of CAR bacilli previously reported in rabbits. The desirability of monitoring laboratory rabbits for CAR bacillus infection as part of the health programme is reinforced, especially in rabbits used for raising sera against respiratory pathogens of animal species in which CAR bacillus infection has been described. This is the first report of natural CAR bacillus infection in rabbits in Europe.
authors.affiliation: Department of Histology and Pathology, Veterinary Faculty, University of Los Palmas de Gran Canaria, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Orós
authors.forename: J B
authors.initials: JB
authors.lastname: Poveda
authors.forename: J L
authors.initials: JL
authors.lastname: Rodríguez
authors.forename: C L
authors.initials: CL
authors.lastname: Franklin
authors.forename: A
authors.initials: A
authors.lastname: Fernández
mesh_terms: D000818:Animals; D001980:Bronchi / Q000382:microbiology / Q000473:pathology / Q000648:ultrastructure; D002923:Cilia / Q000382:microbiology* / Q000648:ultrastructure; D005060:Europe / Q000453:epidemiology; D006090:Gram-Negative Bacteria / Q000302:isolation & purification*; D016905:Gram-Negative Bacterial Infections / Q000453:epidemiology / Q000473:pathology / Q000662:veterinary*; D007106:Immune Sera / Q000096:biosynthesis; D007124:Immunoenzyme Techniques / Q000662:veterinary; D008168:Lung / Q000382:microbiology / Q000473:pathology / Q000648:ultrastructure; D009174:Mycoplasma / Q000276:immunology*; D009175:Mycoplasma Infections / Q000276:immunology / Q000662:veterinary*; D011817:Rabbits; D012189:Retrospective Studies
chemical_list: D007106:Immune Sera