title: [A case of recurrent advanced colon cancer treated with CPT-11 for second-line chemotherapy].
abstract: A 59-year old male patient had been operated on for sigmoid colon cancer in July, 1990. Operative findings were, P0, H0, S1, N (-), Stage I, and histological findings were ss, ly 2, v0, n (-). In July 1994, the CEA level elevated, and be was diagnoted as having para-aortic LN swelling and stenosis of anastomosis of colon. He was admitted for treatment of recurrent colon cancer. Initially, he was treated with continuous injection of 5-FU, low-dose CDDP and Leucovorin. His CEA level decreased and para-aortic LN diminished in size. But, in December 1995, the CEA level and para-aortic LN relapsed. 5-FU, CDDP and Leucovorin were administered, but the CEA level became more and more elevated. This regimen was not considered responsible for drug resistance. CPT-11 was administered at 60 mg/week 6 times, and 80 mg/week 3 times. The side effects disappeared, LN sightly diminished in size, and the CEA level decreased. Judging by the anticancer effect without severe side effect, we found CPT-11 a useful drug for second-line chemotherapy.
authors.affiliation: 2nd Dept. of Internal Medicine, Osaka Medical College.
authors.forename: S
authors.initials: S
authors.lastname: Kawabe
authors.forename: H
authors.initials: H
authors.lastname: Takiuchi
authors.forename: I
authors.initials: I
authors.lastname: Hirata
authors.forename: Y
authors.initials: Y
authors.lastname: Takao
authors.forename: K
authors.initials: K
authors.lastname: Nakagawa
authors.forename: Y
authors.initials: Y
authors.lastname: Egashira
authors.forename: Y
authors.initials: Y
authors.lastname: Nakagawa
authors.forename: K
authors.initials: K
authors.lastname: Katsu
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000627:therapeutic use*; D002166:Camptothecin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D002272:Carcinoembryonic Antigen / Q000032:analysis; D002945:Cisplatin; D003110:Colonic Neoplasms / Q000188:drug therapy* / Q000601:surgery; D019008:Drug Resistance, Neoplasm; D006801:Humans; D000077146:Irinotecan; D002955:Leucovorin; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy*; D012074:Remission Induction
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D002272:Carcinoembryonic Antigen; D000077146:Irinotecan; D002945:Cisplatin; D002955:Leucovorin; D002166:Camptothecin