Coronary artery spasm: a hypothesis on prevention by progesterone.
The mechanism of coronary artery spasm has been hypothesized as follows: the dormant gene of the smooth muscle of the human coronary artery is identical or similar to the active gene of the smooth muscle of ductus arteriosus, but can be activated by estrogen. The activation could be preventable by progesterone. The prevention is due to the reduction of the number of estrogen receptors of the smooth muscle of the coronary artery.
Kanda
I
I
Department of Surgery, Heart Institute of Japan, Tokyo Women's Medical College, Japan.
Endo
M
M
D003329:Coronary Vasospasm / Q000503:physiopathology* / Q000517:prevention & control*; D003331:Coronary Vessels / Q000187:drug effects / Q000502:physiology / Q000503:physiopathology*; D004967:Estrogens / Q000502:physiology; D005786:Gene Expression Regulation / Q000187:drug effects / Q000502:physiology; D006801:Humans; D008955:Models, Cardiovascular; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000502:physiology / Q000503:physiopathology*; D011374:Progesterone / Q000627:therapeutic use*; D011960:Receptors, Estrogen / Q000187:drug effects / Q000378:metabolism
D004967:Estrogens; D011960:Receptors, Estrogen; D011374:Progesterone