Chimerism after organ transplantation.
Recent evidence suggests that passenger leukocytes migrate after organ transplantation and produce persistent chimerism, which is essential for sustained survival of the allograft. Here, we describe how this hematolymphopoietic chimerism provides an important framework for interpretation of post-transplant phenomena and for initiation of therapeutically oriented transplantation research.
Starzl
T E
TE
Pittsburgh Transplantation Institute, Pennsylvania, USA.
Demetris
A J
AJ
Murase
N
N
Trucco
M
M
Thomson
A W
AW
Rao
A S
AS
Fung
J J
JJ
D000818:Animals; D016026:Bone Marrow Transplantation / Q000009:adverse effects / Q000276:immunology; D002678:Chimera / Q000276:immunology*; D006082:Graft Enhancement, Immunologic / Q000009:adverse effects / Q000379:methods; D006085:Graft Survival / Q000276:immunology; D006087:Graft vs Host Reaction / Q000276:immunology; D016298:Hematopoietic Cell Growth Factors / Q000627:therapeutic use; D006789:Host vs Graft Reaction / Q000276:immunology; D006801:Humans; D017708:Leukocyte Transfusion; D008232:Lymphoproliferative Disorders / Q000209:etiology / Q000276:immunology; D008954:Models, Biological; D016377:Organ Transplantation / Q000009:adverse effects; D014181:Transplantation Immunology; D014183:Transplantation, Heterologous; D014184:Transplantation, Homologous
D016298:Hematopoietic Cell Growth Factors