title: Beditine, a new benzodioxane derivative, as a suppressor of human polymorphonuclear leukocyte and platelet activation.
abstract: Beditine, 2-(2-amino-4-thiazolyl)-1,4-benzodioxane hydrochloride is a new substance which reduced platelet activation and degranulation, prevented aggregation and superoxide generation by activated human polymorphonuclear leukocytes (PMNL) and inhibited the activation of arachidonate 5-lipoxygenase. Beditine may, therefore, be a useful agent in the treatment of cardiovascular disease.
authors.affiliation: C. Guelbenkian Research Laboratories of the Drug Agency of the Ministry of Health, Yerevan, Armenia. phanos@drag.iiap.sci.am
authors.forename: A
authors.initials: A
authors.lastname: Panossian
authors.forename: G
authors.initials: G
authors.lastname: Grigorian
authors.forename: S
authors.initials: S
authors.lastname: Akopov
authors.forename: A
authors.initials: A
authors.lastname: Aivasian
authors.forename: E
authors.initials: E
authors.lastname: Markarian
authors.forename: S
authors.initials: S
authors.lastname: Vartanian
authors.forename: E
authors.initials: E
authors.lastname: Gabrielian
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D001241:Aspirin / Q000494:pharmacology; D000001:Calcimycin; D004146:Dioxanes / Q000494:pharmacology*; D015777:Eicosanoids / Q000096:biosynthesis; D006801:Humans; D016859:Lipoxygenase Inhibitors; D009504:Neutrophils / Q000187:drug effects* / Q000378:metabolism; D009543:Nifedipine / Q000494:pharmacology; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D013481:Superoxides / Q000378:metabolism; D013844:Thiazoles / Q000494:pharmacology*
chemical_list: D004146:Dioxanes; D015777:Eicosanoids; D016859:Lipoxygenase Inhibitors; D010975:Platelet Aggregation Inhibitors; D013844:Thiazoles; C107649:beditine; D013481:Superoxides; D000001:Calcimycin; D000255:Adenosine Triphosphate; D009543:Nifedipine; D001241:Aspirin