Severe adverse events in the Italian and Stockholm I pertussis vaccine clinical trials.
The rates of severe side reactions observed in Stockholm I and Italian Trials are reported. Children vaccinated with the same DTPwc in both trials experienced high fever and persistent crying more frequently than in any other group, while similar rates for all the severe side reactions were observed among DTaPs and DT vaccines. Recipients of different DTaP vaccines showed similar rates of severe reactions, which did not differ from recipients of DT vaccines, either in Sweden or Italy.
Ciofi degli Atti
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Istituto Superiore di Sanità, Rome, Italy.
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D002675:Child, Preschool; D004168:Diphtheria Toxoid / Q000009:adverse effects*; D022422:Diphtheria-Tetanus Vaccine; D015721:Diphtheria-Tetanus-Pertussis Vaccine / Q000009:adverse effects*; D022681:Diphtheria-Tetanus-acellular Pertussis Vaccines; D004311:Double-Blind Method; D006801:Humans; D007223:Infant; D007558:Italy; D013548:Sweden; D013745:Tetanus Toxoid / Q000009:adverse effects*; D017778:Vaccines, Combined / Q000009:adverse effects; D014917:Whooping Cough / Q000517:prevention & control*
D004168:Diphtheria Toxoid; D022422:Diphtheria-Tetanus Vaccine; D015721:Diphtheria-Tetanus-Pertussis Vaccine; D022681:Diphtheria-Tetanus-acellular Pertussis Vaccines; D013745:Tetanus Toxoid; D017778:Vaccines, Combined