title: Unexplained syncope: clinical management.
abstract: The management of unexplained syncope begins with the patient's history and physical examination, which are oriented to help separate benign from serious causes. Malignant etiologies are more likely to occur with exertional syncope. Cardiac causes should be considered, particularly cardiomyopathy, postoperative congenital heart disease, right ventricular dysplasia, anomalous coronary artery, pulmonary artery hypertension, myocarditis, long QT syndrome, and Wolff-Parkinson-White syndrome. Neurological and metabolic disorders may underlie a syncope episode. After malignant causes of syncope have been excluded and the diagnosis of neurocardiac syncope has been established, treatment strategies include behavior modification, salt and increased fluids, and pharmacological agents. Efficacious agents include beta-blockers, dysopyramide, fludrocortisones, and alpha agents. Yet, behavior modification alone may be as effective as salt or pharmacological therapy. Because the natural history of neurocardiac syncope in children is spontaneous resolution, it is appropriate to try the simple measures before introducing drug therapy.
authors.affiliation: University of Miami Pediatrics Department, FL 33101, USA.
authors.forename: G S
authors.initials: GS
authors.lastname: Wolff
mesh_terms: D000316:Adrenergic alpha-Agonists / Q000627:therapeutic use; D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D000328:Adult; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use; D001521:Behavior Therapy; D009202:Cardiomyopathies / Q000150:complications; D002648:Child; D003330:Coronary Vessel Anomalies / Q000150:complications; D004206:Disopyramide / Q000627:therapeutic use; D005438:Fludrocortisone / Q000627:therapeutic use; D005440:Fluid Therapy; D006330:Heart Defects, Congenital / Q000150:complications / Q000601:surgery; D006352:Heart Ventricles / Q000002:abnormalities; D006801:Humans; D006976:Hypertension, Pulmonary / Q000150:complications; D008133:Long QT Syndrome / Q000150:complications; D008487:Medical History Taking; D008659:Metabolic Diseases / Q000150:complications; D008901:Mineralocorticoids / Q000627:therapeutic use; D009205:Myocarditis / Q000150:complications; D009422:Nervous System Diseases / Q000150:complications; D010808:Physical Examination; D005082:Physical Exertion; D012982:Sodium, Dietary / Q000627:therapeutic use; D013575:Syncope / Q000209:etiology; D019462:Syncope, Vasovagal / Q000175:diagnosis / Q000209:etiology / Q000628:therapy*; D014927:Wolff-Parkinson-White Syndrome / Q000150:complications
chemical_list: D000316:Adrenergic alpha-Agonists; D000319:Adrenergic beta-Antagonists; D000889:Anti-Arrhythmia Agents; D008901:Mineralocorticoids; D012982:Sodium, Dietary; D004206:Disopyramide; D005438:Fludrocortisone