[Non-natural aglycones of glycopeptide antibiotics of the vancomycin group. Synthesis and antibacterial activity].
A new approach for the modification of the heptapeptide core of glycopeptide antibiotics was proposed based on the replacement of amino acid residues in positions 1 and 3 in teicoplanin aglycone and in position 1 in the eremomycin aglycone. Six novel nonnatural aglycones of the vancomycin type were obtained. Compounds derived from the teicoplanin aglycone exhibited in vitro activity against Gram-positive bacteria, and two of them were also active against the vancomycin-resistant enterococci.
Pavlov
A Iu
AIu
Olsuf'eva
E N
EN
Miroshnikova
O V
OV
Reznikova
M I
MI
Lazhko
E I
EI
Malabarba
A
A
Ciabatti
R
R
Preobrazhenskaia
M N
MN
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D014640:Vancomycin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D014640:Vancomycin