Growth suppression and induction of heat-shock protein-70 by 9-cis beta-carotene in cervical dysplasia-derived cells.
The aim of the present study was to determine to what extent 9-cis beta-carotene, one of the most abundant naturally-occurring cis-isomers of beta-carotene, can inhibit the growth of cervical dysplasia-derived cells in comparison with all-trans beta-carotene. We found that 9-cis beta-carotene was dose-dependently more effective than all-trans beta-carotene. Both carotenes induced the intracellular accumulation of heat-shock protein-70 (HSP70), and the treated cells showed morphological changes indicative of apoptosis. The results of the present study strongly suggest that the induction of HSP70 by beta-carotene might be involved in beta-carotene-mediated suppression of the cell growth through apoptosis.
Toba
T
T
First Department of Internal Medicine, Gifu University School of Medicine, Japan.
Shidoji
Y
Y
Fujii
J
J
Moriwaki
H
H
Muto
Y
Y
Suzuki
T
T
Ohishi
N
N
Yagi
K
K
D002455:Cell Division / Q000187:drug effects*; D002460:Cell Line; D004305:Dose-Response Relationship, Drug; D005260:Female; D018840:HSP70 Heat-Shock Proteins / Q000096:biosynthesis*; D006801:Humans; D002578:Uterine Cervical Dysplasia / Q000473:pathology*; D019207:beta Carotene / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000494:pharmacology
D018840:HSP70 Heat-Shock Proteins; D019207:beta Carotene