title: Smooth pursuit in twins before and after alcohol ingestion.
abstract: OBJECTIVE
  The influence of genetic factors on characteristics of smooth pursuit were evaluated in young adult monozygotic (MZ) and dizygotic (DZ) twins before and after the administration of a single dose of ethanol.
  
  
  METHODS
  Sinusoidal pursuit was recorded using a scleral search coil at frequencies of 0.25 and 0.5 Hz before and after alcohol consumption. Pursuit gain, interval between saccades, saccadic accuracy, and saccadic amplitude were quantified.
  
  
  RESULTS
  Alcohol consumption reduced pursuit gain and saccadic accuracy and increased the rate and amplitude of saccades. Before and after alcohol consumption, the intraclass correlations for MZ twins (rMZ) were highly significant for pursuit gain, interval between saccades, and saccade amplitude. Corresponding correlations for DZ twins (rDZ) were not significant. Heritability values were similar before and after alcohol ingestion.
  
  
  CONCLUSIONS
  The disparity between rMZ and rDZ suggests either multiple gene interactions or common environmental influences for MZ twins, greater than those for DZ twins.
authors.affiliation: Department of Ophthalmology, Indiana University School of Medicine, Indianapolis 46202-5175, USA.
authors.forename: T
authors.initials: T
authors.lastname: Blekher
authors.forename: K
authors.initials: K
authors.lastname: Miller
authors.forename: R D
authors.initials: RD
authors.lastname: Yee
authors.forename: J C
authors.initials: JC
authors.lastname: Christian
authors.forename: L A
authors.initials: LA
authors.lastname: Abel
mesh_terms: D000328:Adult; D000428:Alcohol Drinking / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D011698:Pursuit, Smooth / Q000235:genetics* / Q000502:physiology; D012438:Saccades / Q000502:physiology; D014429:Twins, Dizygotic / Q000235:genetics*; D014430:Twins, Monozygotic / Q000235:genetics*