title: [Expression of thyrotropin receptor gene in autoimmune thyroid disease and the relation to expression of HLA genes].
abstract: OBJECTIVE
  To investigate the expression of TSH receptor in autoimmune thyroid disease (AITD) and the relation to expression of HLA I and II genes.
  
  
  METHODS
  The TSH receptor transcript levels were examined in 10 human thyroid fragments by Northern blot analysis. Graves' disease 7, Hashimoto's disease 2, and 1 healthy thyroid gland.
  
  
  RESULTS
  TSH receptor transcript levels were higher in Graves' disease than in Hashimoto's disease and healthy control.
  
  
  CONCLUSIONS
  TSH receptor expression was inversely related to HLA I and II expression and lymphocyte infiltration.
authors.affiliation: Department of Endocrinology, First Teaching Hospital, Beijing Medical University.
authors.forename: D
authors.initials: D
authors.lastname: Yang
authors.forename: Y
authors.initials: Y
authors.lastname: Gao
authors.forename: C
authors.initials: C
authors.lastname: Li
mesh_terms: D015870:Gene Expression; D005805:Genes, MHC Class I; D005802:Genes, MHC Class II; D006111:Graves Disease / Q000235:genetics*; D006801:Humans; D012333:RNA, Messenger / Q000378:metabolism; D011989:Receptors, Thyrotropin / Q000235:genetics*; D013967:Thyroiditis, Autoimmune / Q000235:genetics*
chemical_list: D012333:RNA, Messenger; D011989:Receptors, Thyrotropin