title: Danish multicenter randomized study of invasive versus conservative treatment in patients with inducible ischemia after thrombolysis in acute myocardial infarction (DANAMI). DANish trial in Acute Myocardial Infarction.
abstract: BACKGROUND
  The aim of the DANish trial in Acute Myocardial Infarction (DANAMI) study was to compare an invasive strategy of percutaneous transluminal coronary angioplasty (PTCA) or coronary artery bypass grafting (CABG) with a conservative strategy in patients with inducible myocardial ischemia who received thrombolytic treatment for a first acute myocardial infarction (AMI).
  
  
  RESULTS
  Of the 503 patients randomized to an invasive strategy, PTCA was performed in 266 (52.9%) and CABG in 147 (29.2%) from 2 to 10 weeks after the AMI. Of the 505 patients in the conservative treatment group, only 8 (1.6%) had been revascularized 2 months after the AMI. The patients were followed up from 1 to 4.5 years. The primary end points were mortality, reinfarction, and admission with unstable angina. At 2.4 years' follow-up (median), mortality was 3.6% in the invasive treatment group and 4.4% in the conservative treatment group (not significant). Invasive treatment was associated with a lower incidence of AMI (5.6% versus 10.5%; P=.0038) and a lower incidence of admission for unstable angina (17.9% versus 29.5%; P<.00001). The percentages of patients with a primary end point were 15.4% and 29.5% at 1 year, 23.5% and 36.6% at 2 years, and 31.7% versus 44.0% at 4 years (P=<.00001) in the invasive and conservative treatment groups, respectively. At 12 months, stable angina pectoris was present in 21% of patients in the invasive treatment group and 43% in the conservative treatment group.
  
  
  CONCLUSIONS
  Invasive treatment in post-AMI patients with inducible ischemia results in a reduction in the incidence of reinfarction, fewer admissions due to unstable angina, and lower prevalence of stable angina. We conclude that patients with inducible ischemia before discharge who have received treatment with thrombolytic drugs for their first AMI should be referred to coronary arteriography and revascularized accordingly.
authors.affiliation: The Heart Centre, Rigshospitalet, National University Hospital, Copenhagen, Denmark.
authors.forename: J K
authors.initials: JK
authors.lastname: Madsen
authors.forename: P
authors.initials: P
authors.lastname: Grande
authors.forename: K
authors.initials: K
authors.lastname: Saunamäki
authors.forename: P
authors.initials: P
authors.lastname: Thayssen
authors.forename: E
authors.initials: E
authors.lastname: Kassis
authors.forename: U
authors.initials: U
authors.lastname: Eriksen
authors.forename: K
authors.initials: K
authors.lastname: Rasmussen
authors.forename: S
authors.initials: S
authors.lastname: Haunsø
authors.forename: T T
authors.initials: TT
authors.lastname: Nielsen
authors.forename: T
authors.initials: T
authors.lastname: Haghfelt
authors.forename: P
authors.initials: P
authors.lastname: Fritz-Hansen
authors.forename: E
authors.initials: E
authors.lastname: Hjelms
authors.forename: P K
authors.initials: PK
authors.lastname: Paulsen
authors.forename: P
authors.initials: P
authors.lastname: Alstrup
authors.forename: H
authors.initials: H
authors.lastname: Arendrup
authors.forename: U
authors.initials: U
authors.lastname: Niebuhr-Jørgensen
authors.forename: L I
authors.initials: LI
authors.lastname: Andersen
mesh_terms: D000328:Adult; D000368:Aged; D000789:Angina, Unstable / Q000209:etiology; D015906:Angioplasty, Balloon, Coronary; D001026:Coronary Artery Bypass; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications / Q000401:mortality / Q000628:therapy*; D017202:Myocardial Ischemia / Q000150:complications / Q000503:physiopathology* / Q000628:therapy*; D012008:Recurrence; D016019:Survival Analysis; D015912:Thrombolytic Therapy