[Effects of Radix angelicae sinensis on systemic and portal hemodynamics in cirrhotics with portal hypertension].
The present study investigated effects of Radix angelicae sinensis (RAS) on systemic and portal hemodynamics in cirrhotic patients with portal hypertension. The results demonstrated that, after intravenous injection of the agent (20 mg.kg-1.min-1), systemic hemodynamics (heart rate, mean arterial pressure, inferior vena cava pressure, systemic vascular resistance, cardiac output, cardiac index) remained unchanged, but portal hemodynamics signicantly improved, wedged hepatic venous pressure (WHVP) (3.79 +/- 0.76 kPa vs 2.72 +/- 0.89 kPa, P < 0.01) and hepatic venous pressure gradient (HVPG) (2.88 +/- 0.73 kPa vs 1.78 +/- 0.68 kPa, P < 0.01) reduced by 29.40 and 35.78 percent respectively. However, anti-portal hypertensive effect of RAS was inverse proportion to the basical level of WHVP or HVPG in the cirrhotics. We conclude that RAS can effectively decrease portal pressure and yet gives no influence on systemic hemodynamics in the cirrhotic patients with portal hypertension.
Huang
Z
Z
Department of Hepatogastroenterology, Shanghai First People's Hospital.
Guo
B
B
Liang
K
K
D000328:Adult; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D006975:Hypertension, Portal / Q000503:physiopathology*; D008103:Liver Cirrhosis / Q000503:physiopathology* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D017082:Portal Pressure / Q000187:drug effects*
D004365:Drugs, Chinese Herbal