title: Minimized proteins.
abstract: The design of bioactive small molecules for interaction at larger protein-protein interfaces remains a challenge. Recent progress towards minimizing proteins into significantly smaller polypeptides has been achieved via both rational design processes and selection from vast combinatorial libraries. Such 'mini-proteins' represent a potential intermediate step toward the development of drugs targeted to protein-protein interfaces.
authors.affiliation: Department of Protein Engineering, Genentech Inc., San Francisco, CA 94080, USA. bcc@gene.com
authors.forename: B C
authors.initials: BC
authors.lastname: Cunningham
authors.forename: J A
authors.initials: JA
authors.lastname: Wells
mesh_terms: D000595:Amino Acid Sequence; D015195:Drug Design; D008969:Molecular Sequence Data; D010455:Peptides / Q000737:chemistry*; D013329:Structure-Activity Relationship
chemical_list: D010455:Peptides