Hypoglycemic action of embelia madagascariensis in normal and diabetic mice.
The hypoglycemic effect of Embelia madagascariensis (Myrsinaceae) was investigated in both normal and streptozotocin-induced diabetic mice. The methanol extract of leaves of Embelia madagascariensis (EL)(500 mg/kg) reduced the blood glucose of normal mice from 206 +/- 9 to 137 +/- 10 mg/100 ml 4 hours after intraperitoneal administration (P < 0.001), and also significantly lowered the blood glucose of streptozotocin-induced diabetic mice from 570 +/- 29 to 401 +/- 59 mg/100 ml under similar conditions (P < 0.05). EL also suppressed epinephrine-induced hyperglycemia in mice (control vs EL, P < 0.01).
Miura
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T
Suzuka University of Medical Science and Technology, Mie, Japan.
Kato
A
A
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D004195:Disease Models, Animal; D007003:Hypoglycemia / Q000139:chemically induced*; D008297:Male; D016488:Medicine, African Traditional; D051379:Mice
D001786:Blood Glucose