title: Loss of heterozygosity at 16q24.1-q24.2 is significantly associated with metastatic and aggressive behavior of prostate cancer.
abstract: Several studies have indicated that in prostate cancer, frequent aberrations take place in several genomic regions. In the present study, we have analyzed allelic losses in chromosome 16 region q in 50 prostate cancer specimens of various histological grades. The most frequently deleted region was located at 16q23-16q24.2 between loci D16S504 and D16S422. The highest percentage of loss of heterozygosity (LOH) at 16q was also found within this area at loci HSD17B2 and D16S422 located at 16q24.1-q24.2. The LOH at 16q24.1-q24.2 was significantly associated with clinically aggressive behavior of the disease, metastatic disease, and higher tumor grade. Of the metastatic diseases, 83% showed LOH, whereas only 40% of the nonmetastatic diseases were found to show it. Similarly, LOH was found in 76% of the clinically aggressive diseases and in 33% of the nonaggressive diseases. The data suggest that a potentially important gene associated with prostate cancer progression is located close to 16q24.1-q24.2.
authors.affiliation: Biocenter Oulu, WHOCCR and Department of Clinical Chemistry, University of Oulu, Finland.
authors.forename: J P
authors.initials: JP
authors.lastname: Elo
authors.forename: P
authors.initials: P
authors.lastname: Härkönen
authors.forename: A P
authors.initials: AP
authors.lastname: Kyllönen
authors.forename: O
authors.initials: O
authors.lastname: Lukkarinen
authors.forename: M
authors.initials: M
authors.lastname: Poutanen
authors.forename: R
authors.initials: R
authors.lastname: Vihko
authors.forename: P
authors.initials: P
authors.lastname: Vihko
mesh_terms: D002874:Chromosome Mapping; D002885:Chromosomes, Human, Pair 16 / Q000235:genetics*; D017353:Gene Deletion; D006801:Humans; D008297:Male; D018895:Microsatellite Repeats; D009362:Neoplasm Metastasis / Q000235:genetics; D011471:Prostatic Neoplasms / Q000235:genetics* / Q000473:pathology*