Heterocyclic structures useful in medicinal chemistry: the case of pyrazino[2,3-c][1,2,6]thiadiazine 2,2-dioxide.
Different aspects of a particular kind of heterocycle, namely pyrazino[2,3-c][1,2,6]thiadiazine 2,2-dioxide are discussed. These include synthesis, reactivity, tautomerism and acid-base properties, results of x-ray analysis and molecular orbital calcultations. Besides, some of the derivatives have shown interesting biological effects, among which are the diuretic properties which are also presented.
Goya
P
P
Instituto de Química Médica (C.S.I.C.), Madrid, Spain.
Campillo
N
N
García-Gómez
C
C
Páez
J A
JA
Alkorta
I
I
D000818:Animals; D004232:Diuretics / Q000138:chemical synthesis* / Q000494:pharmacology; D011719:Pyrazines / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D013829:Thiadiazines / Q000138:chemical synthesis* / Q000494:pharmacology
D004232:Diuretics; D011719:Pyrazines; D013829:Thiadiazines; C107838:pyrazino(2,3-c)(1,2,6)thiadiazine-2,2-dioxide