title: Keratoprosthesis results in animals: an update.
abstract: BACKGROUND
  The report presented is an update on continuing development work on modified PHEMA core-and-shirt KPros in animals.
  
  
  METHODS
  Two variations (improved wet-eye, and dry-eye) of a prototype core-and-skirt Chirila KPro are described. The clinical success rate on implantation of these versions of the Chirila KPro was assessed.
  
  
  RESULTS
  It was found that a significant improvement in retention rate was shown in the improved model but that the dry-eye model failed early in two of the three implanted.
  
  
  CONCLUSIONS
  The significance of the improved strength and the reasons for disappointing results with the early dry-eye KPros are discussed. Ongoing work is briefly outlined.
authors.affiliation: Lions Eye Institute, Nedlands, Australia.
authors.forename: C R
authors.initials: CR
authors.lastname: Hicks
authors.forename: X
authors.initials: X
authors.lastname: Lou
authors.forename: S
authors.initials: S
authors.lastname: Platten
authors.forename: A B
authors.initials: AB
authors.lastname: Clayton
authors.forename: S
authors.initials: S
authors.lastname: Vijayasekaran
authors.forename: H J
authors.initials: HJ
authors.lastname: Fitton
authors.forename: T V
authors.initials: TV
authors.lastname: Chirila
authors.forename: G J
authors.initials: GJ
authors.lastname: Crawford
authors.forename: I J
authors.initials: IJ
authors.lastname: Constable
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D003315:Cornea / Q000473:pathology / Q000601:surgery*; D005500:Follow-Up Studies; D008689:Methacrylates; D011183:Postoperative Complications; D019736:Prostheses and Implants / Q000009:adverse effects; D011817:Rabbits; D013552:Swine
chemical_list: D001672:Biocompatible Materials; D008689:Methacrylates; C005044:hydroxyethyl methacrylate