title: Lymph node metastasis in carcinoma of the body and tail of the pancreas.
abstract: BACKGROUND
  There have been no precise reports concerning lymph node metastatic involvement in carcinoma of the body and tail of the pancreas.
  
  
  METHODS
  Histopathological examination of lymph node involvement in 30 specimens obtained from patients who underwent pancreatic resection and wide dissection of lymph nodes, including para-aortic lymph nodes, for carcinoma of the body and tail of the pancreas was performed.
  
  
  RESULTS
  Fourteen of 30 patients had lymph node involvement. The highest incidence of lymph node involvement was around the splenic artery (five of 30 patients), aorta (four of 30) and coeliac trunk (four of 30). No significant difference in survival rate between the lymph node-negative group and the lymph node-positive group was observed, but all patients in the positive group died within 2 years after surgery, and four patients with para-aortic lymph node involvement died from recurrence within 10 months after surgery. Survival rates were significantly worse in patients with histopathological extrapancreatic nerve plexus invasion, retropancreatic tissue invasion, tumour diameter more than 4 cm, histological portal system vein wall invasion and carcinoma invasion of the surgical margins.
  
  
  CONCLUSIONS
  Although aggressive extended surgery including para-aortic node dissection has been performed, the postoperative survival rate is still low in patients with carcinoma of the body and tail of the pancreas. The high incidence of liver metastasis after surgery is a prime cause of the poor outcome, and effective therapy for postoperative liver recurrence requires evaluation.
authors.affiliation: Department of Surgery II, Nagoya University School of Medicine, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Nakao
authors.forename: A
authors.initials: A
authors.lastname: Harada
authors.forename: T
authors.initials: T
authors.lastname: Nonami
authors.forename: T
authors.initials: T
authors.lastname: Kaneko
authors.forename: S
authors.initials: S
authors.lastname: Nomoto
authors.forename: H
authors.initials: H
authors.lastname: Koyama
authors.forename: N
authors.initials: N
authors.lastname: Kanazumi
authors.forename: N
authors.initials: N
authors.lastname: Nakashima
authors.forename: H
authors.initials: H
authors.lastname: Takagi
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008197:Lymph Node Excision; D008207:Lymphatic Metastasis / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D010179:Pancreas; D010190:Pancreatic Neoplasms / Q000473:pathology* / Q000601:surgery; D015996:Survival Rate; D016896:Treatment Outcome