title: [Deficit in selective attention and its evolution in depression].
abstract: Selective attention was measured in 34 depressed patients and 34 controls using a computerized version of the Stroop test, that included a manipulation of the stimulus onset asynchrony (SCA) in order to explore the efficacy of cognitive inhibition as a function of depression and of clinical amelioration of degression after therapy. Clinical tests included a measure of psychomotor slowing [Echelle de Ralentissement de Widlöcher (ERD), the Hamilton (Psychiatric Rating Scale for Depression (HAMD), and the Brief Psychiatric Rating Scale (BPRS)]. Selective attention was measured with the Stroop test, which includes four measures: Word, Color, Color-Word, and Color-Word minus Color, or interference. All of these measures were deficient in the depressed patients, particularly Stroop interference. Even when additional time was given to inhibit the Stroop distractor in the SOA condition, depressed subjects still showed significantly inferior performance. After four weeks of anti-depressive treatment, fifteen of the patients were retested, and showed significant improvement on all the Stroop measures, particularly on Stroop interference. The improvement in performance on the attentional measures was comparable in magnitude to that seen on the clinical scales, and suggests that the interference measure can be a sensitive indicator of clinical status in depressed patients.
authors.affiliation: INSERM (Unité 302), Groupe hospitalier Pitié-Salpêtrière, Paris.
authors.forename: J
authors.initials: J
authors.lastname: Thomas
authors.forename: N
authors.initials: N
authors.lastname: Raoux
authors.forename: J
authors.initials: J
authors.lastname: Everett
authors.forename: N
authors.initials: N
authors.lastname: Dantchev
authors.forename: D
authors.initials: D
authors.lastname: Widlöcher
mesh_terms: D000328:Adult; D000928:Antidepressive Agents / Q000627:therapeutic use; D001288:Attention / Q000187:drug effects; D003118:Color Perception / Q000187:drug effects; D003866:Depressive Disorder / Q000175:diagnosis* / Q000188:drug therapy / Q000523:psychology; D004193:Discrimination Learning / Q000187:drug effects; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010555:Personality Inventory; D011930:Reaction Time; D011932:Reading; D012660:Semantics
chemical_list: D000928:Antidepressive Agents