[Mechanism of plasma endothelin-1 level elevation and its relation with pulmonary hypertension in chronic cor pulmonale].
To explore the mechanism of plasma endothelin-1 (ET-1) level elevation and its relation with pulmonary hypertension in chronic cor pulmonale, plasma ET-1 level was measured by using radioimmunoassay in 21 cases of chronic cor pulmonale with acute exacerbation and cardiac catheterization was performed simultaneously. Results, Peripheral venous plasma ET-1 level of the patients was significantly higher than that of controls and also higher than that of peripheral arterial and pulmonary arterial plasma ET-1 level of the patients themselves. The plasma ET-1 level of patients had a significant negative correlation with PaO2 and SaO2 and positive correlation with mean pulmonary arterial pressure (PAPM) and pulmonary vascular resistance index (PVRI). 9 of the patients were treated with mechanical ventilation. After ventilation, PaO2 went up notably and plasma ET-1 level decreased remarkably, PAPM and PVRI also reduced simultaneously.


CONCLUSIONS
The causes of plasma ET-1 level elevation in cor pulmonale may be as follows, Firstly, pulmonary alveolar hypoxia increases the release of ET-1 in lungs; Secondly, the ability of the lungs to clean ET-1 decreases because of pulmonary abnormality. High level of plasma ET-1 may induce pulmonary hypertension. The level of plasma ET-1 can be lowered by correcting hypoxic status of the patients and the resulting improvement of pulmonary hemodynamics.
Zhang
J
J
Department of Respiratory Diseases, Beijing Red Cross Chaoyang Hospital.
Kong
W
W
Wang
C
C
D000368:Aged; D019332:Endothelin-1 / Q000097:blood*; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011651:Pulmonary Artery / Q000503:physiopathology; D011660:Pulmonary Heart Disease / Q000503:physiopathology* / Q000628:therapy; D012121:Respiration, Artificial; D014655:Vascular Resistance
D019332:Endothelin-1