Meat intake, heterocyclic amines, and risk of breast cancer: a case-control study in Uruguay.
To study the effects of meat intake, including heterocyclic amine exposure, on the risk of breast cancer, we conducted a hospital-based case-control study involving 352 patients with breast cancer and 382 controls. A strong effect of red meat, total meat, beef, fried meat, and heterocyclic amine exposure was found, after controlling for potential confounders. The odds ratio for the highest quartile of 2-amino-3-methylimidazo [4,5-f]quinoline exposure was 3.34 (95% confidence interval 1.85-6.02). According to these results, meat intake and chemicals formed during the cooking process appear to be strong risk factors in human breast carcinogenesis.
De Stefani
E
E
Registro Nacional de Cancer, Department 402, Montevideo, Uruguay.
Ronco
A
A
Mendilaharsu
M
M
Guidobono
M
M
Deneo-Pellegrini
H
H
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000453:epidemiology*; D002273:Carcinogens; D016022:Case-Control Studies; D015984:Causality; D016001:Confidence Intervals; D003296:Cooking; D003430:Cross-Sectional Studies; D005247:Feeding Behavior; D005260:Female; D006801:Humans; D015994:Incidence; D008460:Meat / Q000009:adverse effects*; D008875:Middle Aged; D016017:Odds Ratio; D011804:Quinolines / Q000009:adverse effects*; D012307:Risk Factors; D014505:Urban Population / Q000706:statistics & numerical data; D014583:Uruguay / Q000453:epidemiology
D002273:Carcinogens; D011804:Quinolines; C029216:2-amino-3-methylimidazo(4,5-f)quinoline