title: Bronchiolitis obliterans and IgA nephropathy. A new cause of pulmonary-renal syndrome.
abstract: IgA nephropathy is a common form of glomerulonephritis, classically manifested by asymptomatic hematuria. Although the exact pathophysiologic mechanism is still unknown, renal damage has been related to mesangial deposition of IgA-containing immune complexes. In recent years, some lung diseases have been associated with IgA nephropathy, including pulmonary hemorrhage and sarcoidosis. We report a patient with idiopathic bronchiolitis obliterans who developed a rapidly progressive glomerulonephritis due to IgA deposits. Extensive deposits of IgA were also found in the lungs, thus suggesting a pathogenetic role for IgA in tissue injury at both organ levels. To our knowledge this association has not been previously described in the literature.
authors.affiliation: Department of Internal Medicine, Hospital Marqués de Valdecilla, University of Cantabria, Santander, Spain.
authors.forename: J I
authors.initials: JI
authors.lastname: Hernández
authors.forename: J
authors.initials: J
authors.lastname: Gómez-Román
authors.forename: E
authors.initials: E
authors.lastname: Rodrigo
authors.forename: J M
authors.initials: JM
authors.lastname: Olmos
authors.forename: C
authors.initials: C
authors.lastname: González-Vela
authors.forename: J C
authors.initials: JC
authors.lastname: Ruiz
authors.forename: J F
authors.initials: JF
authors.lastname: Val
authors.forename: J A
authors.initials: JA
authors.lastname: Riancho
mesh_terms: D000368:Aged; D019867:Anti-Glomerular Basement Membrane Disease / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology; D000936:Antigen-Antibody Complex / Q000032:analysis; D001706:Biopsy; D001989:Bronchiolitis Obliterans / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D017809:Fatal Outcome; D005920:Glomerular Mesangium / Q000276:immunology; D005922:Glomerulonephritis, IGA / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007668:Kidney / Q000473:pathology; D008168:Lung / Q000473:pathology; D008297:Male
chemical_list: D000936:Antigen-Antibody Complex; D007070:Immunoglobulin A