title: In vitro postantibiotic effect of imipenem and enoxacin alone and in combination against Pseudomonas aeruginosa.
abstract: The postantibiotic effects (PAEs), i.e. suppression of growth of three Pseudomonas aeruginosa strains (386, 648, 659) after a short treatment (30 min) with imipenem and enoxacin alone and in combination were evaluated. Imipenem (2 x MIC) induced PAEs for two strains for 0.5 h (386, 648) at concentrations of 4 x MIC, PAEs lasted 0.8 h (386), 2 h (648) and 1.5 h (659). The PAE values of enoxacin (2 x MIC) were 4.6 h (386), 1.7 h (648), 1.6 h (659) and those of enoxacin (4 x MIC) were 6.1 h (386), 3.2 h (648) and 2.1 h (659). PAEs manifested by an imipenem/enoxacin combination were longer than the mathematical sum of PAEs induced by individual antibiotics. Prolongation of PAEs induced by the imipenem (2 x MIC)/enoxacin (2 x MIC) combination was 25.5% and 27.3% (strains 386 and 648) as well as 27.8%, 32.4% and 16.1% (strains 386, 648 and 659) after treatment with imipenem (4 x MIC)/enoxacin (2 x MIC).
authors.affiliation: Institute of Preventive and Clinical Medicine, Bratislava, Slovak Republic.
authors.forename: A
authors.initials: A
authors.lastname: Hostacká
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology*; D015780:Carbapenems / Q000494:pharmacology*; D004359:Drug Therapy, Combination / Q000494:pharmacology*; D015365:Enoxacin / Q000494:pharmacology*; D015378:Imipenem / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D011550:Pseudomonas aeruginosa / Q000187:drug effects*
chemical_list: D000890:Anti-Infective Agents; D015780:Carbapenems; D015365:Enoxacin; D015378:Imipenem