title: Efficacy of laser-assisted uvulopalatoplasty.
abstract: OBJECTIVE
  Laser-assisted uvulopalatoplasty (LAUP) is being used increasingly as a surgical treatment for snoring and obstructive sleep apnea (OSA). There is limited evidence for the success of LAUP in eliminating OSA. This study assesses the efficacy of LAUP in eliminating snoring and OSA and addresses which patients may be the best candidates for LAUP treatment.
  
  
  METHODS
  From January 1994 to January 1996, 297 patients were evaluated for snoring, with 190 (64%) exhibiting some degree of OSA documented by a PSG: 41/ 190 (22%) mild OSA; 33/190 (17%) moderate OSA; 85/190 (45%) severe OSA; 31/190 (16%) severity unknown. Ninety patients (90/ 297) have undergone LAUP treatment: 58/90 (64%) with OSA and 32/90 (36%) with snoring only.
  
  
  RESULTS
  Our results indicate a significant reduction of snoring in patients without OSA, but diminishing success in patients with increasing degrees of OSA. Additionally, LAUP was not efficacious in treating OSA: pre-op respiratory disturbance index (RDI) of 10.8 vs. post-op RDI of 19.5 for mild OSA (P = 0.14); pre-op RDI of 22.9 vs. post-op RDI of 25.4 for moderate OSA (P = 0.43); pre-op RDI of 56.8 vs. post-op RDI of 46.3 (P < 0.05), which is statistically but not clinically significant (i.e., RDI remained in the severe range).
  
  
  CONCLUSIONS
  We conclude that LAUP is an effective treatment for nonapneic snoring, but does not provide sufficient resolution of OSA, and based on our results, LAUP should be considered as an adjunctive therapy rather than a sole treatment for OSA in most cases.
authors.affiliation: Department of Otology & Laryngology, Harvard Medical School, Joint Center for Otolaryngology, Boston, Massachusetts, USA.
authors.forename: A M
authors.initials: AM
authors.lastname: Lauretano
authors.forename: R K
authors.initials: RK
authors.lastname: Khosla
authors.forename: G
authors.initials: G
authors.lastname: Richardson
authors.forename: J
authors.initials: J
authors.lastname: Matheson
authors.forename: J W
authors.initials: JW
authors.lastname: Weiss
authors.forename: C
authors.initials: C
authors.lastname: Graham
authors.forename: M P
authors.initials: MP
authors.lastname: Fried
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000556:Ambulatory Surgical Procedures; D006801:Humans; D053685:Laser Therapy; D008297:Male; D008875:Middle Aged; D010160:Palate, Soft / Q000601:surgery*; D017060:Patient Satisfaction; D017286:Polysomnography; D012891:Sleep Apnea Syndromes / Q000503:physiopathology / Q000601:surgery*; D012913:Snoring / Q000503:physiopathology / Q000601:surgery*; D014609:Uvula / Q000601:surgery*