[Antihypertensive therapy and heart diseases].
The one of the most important goal of antihypertensive therapy is to prevent and improve the hypertensive heart disease including cardiac hypertrophy and ischemic heart disease. The regression of cardiac hypertrophy by treatment reduce the risk of cardiovascular events. ACE inhibitor (ACEI) may be the most powerful among antihypertensive agents to regress hypertrophy. Ca-antagonist and ACEI can improve the impaired coronary flow reserve by microvascular circulation. Recently, the evidences have been accumulated that the release of nitric oxide (NO) from the coronary artery of hypertension is reduced. "TREND" study proved that ACEI can improve this decreases in the clinical study. For the heart failure, ACEI is a effective drugs, and Ca-antagonist and beta-blocker also have been getting good results.
Takeda
K
K
Second Department of Medicine, Kyoto Prefectural University of Medicine.
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use*; D002121:Calcium Channel Blockers / Q000627:therapeutic use; D002312:Cardiomyopathy, Hypertrophic / Q000517:prevention & control*; D002986:Clinical Trials as Topic; D003331:Coronary Vessels / Q000378:metabolism; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D017202:Myocardial Ischemia / Q000517:prevention & control*; D009569:Nitric Oxide / Q000378:metabolism
D000319:Adrenergic beta-Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors; D002121:Calcium Channel Blockers; D009569:Nitric Oxide