In vitro postantibiotic effect of imipenem and enoxacin alone and in combination against Pseudomonas aeruginosa.
The postantibiotic effects (PAEs), i.e. suppression of growth of three Pseudomonas aeruginosa strains (386, 648, 659) after a short treatment (30 min) with imipenem and enoxacin alone and in combination were evaluated. Imipenem (2 x MIC) induced PAEs for two strains for 0.5 h (386, 648) at concentrations of 4 x MIC, PAEs lasted 0.8 h (386), 2 h (648) and 1.5 h (659). The PAE values of enoxacin (2 x MIC) were 4.6 h (386), 1.7 h (648), 1.6 h (659) and those of enoxacin (4 x MIC) were 6.1 h (386), 3.2 h (648) and 2.1 h (659). PAEs manifested by an imipenem/enoxacin combination were longer than the mathematical sum of PAEs induced by individual antibiotics. Prolongation of PAEs induced by the imipenem (2 x MIC)/enoxacin (2 x MIC) combination was 25.5% and 27.3% (strains 386 and 648) as well as 27.8%, 32.4% and 16.1% (strains 386, 648 and 659) after treatment with imipenem (4 x MIC)/enoxacin (2 x MIC).
Hostacká
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Institute of Preventive and Clinical Medicine, Bratislava, Slovak Republic.
D000890:Anti-Infective Agents / Q000494:pharmacology*; D015780:Carbapenems / Q000494:pharmacology*; D004359:Drug Therapy, Combination / Q000494:pharmacology*; D015365:Enoxacin / Q000494:pharmacology*; D015378:Imipenem / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D011550:Pseudomonas aeruginosa / Q000187:drug effects*
D000890:Anti-Infective Agents; D015780:Carbapenems; D015365:Enoxacin; D015378:Imipenem