title: Ocular growth in newborn rabbit eyes implanted with a poly(methyl methacrylate) or silicone intraocular lens.
abstract: OBJECTIVE
  To examine eye growth in lensectomized infant rabbits implanted with a poly(methyl methacrylate) (PMMA) or a silicone intraocular lens (IOL).
  
  
  METHODS
  S:t Eriks Eye Hospital, Karolinska Institute, Stockholm, Sweden.
  
  
  METHODS
  Two groups of 3-week-old rabbits were used. In Group 1 (n = 13), lensectomy was performed in both eyes. In one randomly selected eye, a +30 diopter (D) heparin-surface-modified (HSM) PMMA IOL was implanted in the capsular bag; the other eye was left aphakic. In Group 2 (n = 10), a +21 D HSM PMMA IOL was implanted in one randomly selected eye and a +21 D silicone IOL was implanted in the other. Axial length, corneal diameter, corneal thickness, and intraocular pressure (IOP) were measured in all eye preoperatively and 1, 2, and 3 months after surgery. The wet mass of the after-cataract was measured 3 months after surgery. The ciliary body with the ciliary processes and the peripheral retina were examined histologically after formalin fixation. The two IOL types were compressed to 7.0 MM, corresponding to the diameter of the 3-week-old rabbit lens.
  
  
  RESULTS
  In Group 1, the axial length was significantly decreased in the eye with an HSM PMMA IOL compared with the fellow aphakic eye (P < .01, two-way analysis of variance [ANOVA]). No significant difference in corneal diameter, corneal thickness, or IOP was found between the eyes. The wet mass of the dissected after-cataract was significantly less in the eye implanted with an IOL. Two animals had an elevated IOP with secondary glaucoma in their aphakic eye and were excluded from the study. In Group 2, axial length in eyes with the HSM PMMA IOL was less than in the eyes with the silicone IOL (P < .25, two-way ANOVA). No difference in corneal diameter, corneal thickness, or IOP was found. The amount of after-cataract was not altered. Histologically, the eyes with the HSM PMMA IOL showed retinal degeneration, neovascularization of the ciliary body accompanied by a large number of inflammatory cells, and tumid ciliary processes. The eyes with the silicone IOL showed only minor changes. The aphakic eyes presented even less histological change. The compression test demonstrated that three time the compression force was needed to squeeze the HSM PMMA lens than the silicone IOL.
  
  
  CONCLUSIONS
  The results suggest that in the young rabbit eye, implanting a regular size HSM PMMA IOL destroys intraocular tissues and reduces eye growth significantly. Replacing the PMMA IOL with a silicone IOL improves the ocular growth.
authors.affiliation: Department of Ophthalmology, S:t Eriks Eye Hospital/Karolinska Institute, Stockholm, Sweden.
authors.forename: U
authors.initials: U
authors.lastname: Kugelberg
authors.forename: C
authors.initials: C
authors.lastname: Zetterström
authors.forename: B
authors.initials: B
authors.lastname: Lundgren
authors.forename: S
authors.initials: S
authors.lastname: Syrén-Nordqvist
mesh_terms: D000818:Animals; D000831:Animals, Newborn / Q000254:growth & development*; D002924:Ciliary Body / Q000098:blood supply; D005123:Eye / Q000254:growth & development*; D007910:Lenses, Intraocular; D020366:Methylmethacrylate; D008768:Methylmethacrylates / Q000009:adverse effects; D009389:Neovascularization, Pathologic / Q000209:etiology / Q000473:pathology; D011183:Postoperative Complications / Q000209:etiology / Q000473:pathology; D011817:Rabbits; D011897:Random Allocation; D012162:Retinal Degeneration / Q000209:etiology / Q000473:pathology; D012826:Silicone Elastomers / Q000009:adverse effects
chemical_list: D008768:Methylmethacrylates; D012826:Silicone Elastomers; D020366:Methylmethacrylate