p75 neurotrophin receptor immunoreactivity in the aged human hypothalamus.
Low-affinity p75 neurotrophin receptor (p75NTR) immunoreactivity in the aged human hypothalamus was examined in autopsied material. Numerous p75NTR-immunoreactive cells were found in the paraventricular and supraoptic hypothalamic nuclei. The suprachiasmatic nucleus was devoid of p75NTR-immunostaining. Many p75NTR-immunoreactive fibers extended laterally and ventrally from the paraventricular and supraoptic nuclei into the pituitary stalk and median eminence. Our results suggest that neurotrophins may be present within the human hypothalamo-hypophyseal system.
Moga
M M
MM
Department of Anatomy, Indiana University School of Medicine, Terre Haute 47809, USA. mefmoga@thcme.indstate.edu
Duong
T
T
D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D000918:Antibody Specificity; D005260:Female; D006801:Humans; D007032:Hypothalamus, Anterior / Q000737:chemistry*; D007150:Immunohistochemistry; D010286:Paraventricular Hypothalamic Nucleus / Q000737:chemistry; D020800:Receptor, Nerve Growth Factor; D017475:Receptors, Nerve Growth Factor / Q000032:analysis / Q000276:immunology*; D013493:Suprachiasmatic Nucleus / Q000737:chemistry; D013495:Supraoptic Nucleus / Q000737:chemistry
D020800:Receptor, Nerve Growth Factor; D017475:Receptors, Nerve Growth Factor