Effect of different combinations of sparfloxacin, oxacillin, and fosfomycin against methicillin-resistant staphylococci.
The in vitro activity of combinations of sparfloxacin/oxacillin, sparfloxacin/fosfomycin, and oxacillin/fosfomycin was investigated against 16 methicillin-resistant Staphylococcus aureus (MRSA) isolates and 12 methicillin-resistant Staphylococcus epidermidis (MRSE) isolates moderately resistant to sparfloxacin. Synergic interactions were observed more frequently against MRSE than against MRSA strains. The most effective combination on both species was fosfomycin plus oxacillin, synergistic against ten of 16 MRSA and eight of 12 MRSE strains.
Ferrara
A
A
Cattedra di Chemioterapia, Università di Pavia, Padiglione Forlanini, Policlinico San Matteo, Italia.
Dos Santos
C
C
Cimbro
M
M
Gialdroni Grassi
G
G
D000890:Anti-Infective Agents / Q000494:pharmacology; D004357:Drug Synergism; D004359:Drug Therapy, Combination / Q000494:pharmacology*; D024841:Fluoroquinolones; D005578:Fosfomycin / Q000494:pharmacology*; D016106:Methicillin Resistance; D008826:Microbial Sensitivity Tests; D010068:Oxacillin / Q000494:pharmacology*; D015363:Quinolones / Q000494:pharmacology*; D013210:Staphylococcus / Q000187:drug effects*
D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D015363:Quinolones; D005578:Fosfomycin; C061363:sparfloxacin; D010068:Oxacillin