title: Time series analysis of the course of Menière's disease.
abstract: Subjective symptoms of Menière's disease (vertiginous attacks, nonparoxysmal dizziness, tinnitus, hearing loss, headache, stiff neck, nausea etc.) were graded respectively according to severity (0-3 or 0-5) and were recorded daily by affected patients. These recordings, from 20 cases of Menière's disease, were collected and analysed by an original program of time series analysis including autocorrelation, cross-correlation, daily sum of inner ear related factors and general factors, and their moving average. Cluster occurrence of dizzy spells in the active stage and a marked cross-correlation between inner ear factors and general factors were found to constitute a characteristic pattern in Menière's disease in relation to its pathophysiology. Time series analysis was also useful for clinical decision-making, such as evaluation of the effect of treatment, and estimation of prognosis.
authors.affiliation: Division of Electronic Engineering, Tokyo Medical and Dental University, Japan.
authors.forename: I
authors.initials: I
authors.lastname: Watanabe
authors.forename: S
authors.initials: S
authors.lastname: Imai
authors.forename: M
authors.initials: M
authors.lastname: Ikeda
authors.forename: A
authors.initials: A
authors.lastname: Ishida
mesh_terms: D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001145:Arrhythmias, Cardiac / Q000503:physiopathology; D016000:Cluster Analysis; D003196:Computer Graphics; D003657:Decision Making; D004244:Dizziness / Q000503:physiopathology; D007758:Ear, Inner / Q000503:physiopathology; D005221:Fatigue / Q000503:physiopathology; D005260:Female; D005767:Gastrointestinal Diseases / Q000503:physiopathology; D006261:Headache / Q000503:physiopathology; D006311:Hearing Disorders / Q000503:physiopathology; D006801:Humans; D008297:Male; D008499:Medical Records; D008575:Meniere Disease / Q000188:drug therapy / Q000503:physiopathology*; D008875:Middle Aged; D009325:Nausea / Q000503:physiopathology; D019547:Neck Pain / Q000503:physiopathology; D011239:Prednisolone / Q000627:therapeutic use; D011379:Prognosis; D012720:Severity of Illness Index; D012893:Sleep Wake Disorders / Q000503:physiopathology; D012984:Software; D013223:Statistics as Topic; D013997:Time Factors; D014012:Tinnitus / Q000503:physiopathology; D014717:Vertigo / Q000503:physiopathology
chemical_list: D000893:Anti-Inflammatory Agents; D011239:Prednisolone