Hypertensive heart disease: quantitative evaluation of response to therapy with cine MR imaging.
OBJECTIVE
To assess the ability of cine magnetic resonance (MR) imaging to help detect and quantity changes in left ventricular parameters in patients receiving antihypertensive therapy.


METHODS
After undergoing baseline cine MR imaging of the heart, 16 (12 men, four women) hypertensive patients participating in a prospective drug trial began isradipine therapy. Follow-up serial cine MR imaging was performed at 3 months and 6 months. Myocardial mass, end-systolic volume, end-diastolic volume, stroke volume, and ejection fraction were measured. Results from transaxially acquired three-dimensional data sets and monoplanar imaging were compared.


RESULTS
Three dimensional data showed reductions of 11% in end-systolic volume (P = .0051) and 17% in end-diastolic volume (P = .0023). These changes were not detected with monoplanar imaging. Changes in myocardial mass, stroke volume, and ejection fraction were not statistically significant.


CONCLUSIONS
Three-dimensional cine MR imaging can depict small yet statistically significant reductions in left ventricular volumes in response to antihypertensive therapy.
Albrecht
T
T
Department of Imaging, Hammersmith Hospital, London, England.
Dulce
M C
MC
Dulce
K K
KK
Gotzen
R
R
Wolf
K J
KJ
D000328:Adult; D000704:Analysis of Variance; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D002306:Cardiac Volume; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy*; D017379:Hypertrophy, Left Ventricular / Q000175:diagnosis* / Q000209:etiology; D017275:Isradipine / Q000627:therapeutic use*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008433:Mathematics; D008875:Middle Aged; D015588:Observer Variation; D011446:Prospective Studies; D013318:Stroke Volume; D016277:Ventricular Function, Left / Q000187:drug effects*
D000959:Antihypertensive Agents; D017275:Isradipine