title: Effect of calcium and vitamin D supplementation on bone density in men and women 65 years of age or older.
abstract: BACKGROUND
  Inadequate dietary intake of calcium and vitamin D may contribute to the high prevalence of osteoporosis among older persons.
  
  
  METHODS
  We studied the effects of three years of dietary supplementation with calcium and vitamin D on bone mineral density, biochemical measures of bone metabolism, and the incidence of nonvertebral fractures in 176 men and 213 women 65 years of age or older who were living at home. They received either 500 mg of calcium plus 700 IU of vitamin D3 (cholecalciferol) per day or placebo. Bone mineral density was measured by dual-energy x-ray absorptiometry, blood and urine were analyzed every six months, and cases of nonvertebral fracture were ascertained by means of interviews and verified with use of hospital records.
  
  
  RESULTS
  The mean (+/-SD) changes in bone mineral density in the calcium-vitamin D and placebo groups were as follows: femoral neck, +0.50+/-4.80 and -0.70+/-5.03 percent, respectively (P=0.02); spine,+2.12+/-4.06 and +1.22+/-4.25 percent (P=0.04); and total body, +0.06+/-1.83 and -1.09+/-1.71 percent (P<0.001). The difference between the calcium-vitamin D and placebo groups was significant at all skeletal sites after one year, but it was significant only for total-body bone mineral density in the second and third years. Of 37 subjects who had nonvertebral fractures, 26 were in the placebo group and 11 were in the calcium-vitamin D group (P=0.02).
  
  
  CONCLUSIONS
  In men and women 65 years of age or older who are living in the community, dietary supplementation with calcium and vitamin D moderately reduced bone loss measured in the femoral neck, spine, and total body over the three-year study period and reduced the incidence of nonvertebral fractures.
authors.affiliation: Jean Mayer U.S. Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA.
authors.forename: B
authors.initials: B
authors.lastname: Dawson-Hughes
authors.forename: S S
authors.initials: SS
authors.lastname: Harris
authors.forename: E A
authors.initials: EA
authors.lastname: Krall
authors.forename: G E
authors.initials: GE
authors.lastname: Dallal
mesh_terms: D000368:Aged; D015519:Bone Density / Q000187:drug effects*; D002118:Calcium / Q000097:blood / Q000494:pharmacology / Q000627:therapeutic use*; D019343:Citric Acid / Q000494:pharmacology / Q000627:therapeutic use*; D003094:Collagen / Q000652:urine; D024042:Collagen Type I; D004311:Double-Blind Method; D005260:Female; D005272:Femur Neck / Q000187:drug effects; D050723:Fractures, Bone / Q000453:epidemiology / Q000517:prevention & control*; D006801:Humans; D015994:Incidence; D008293:Malates / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D015675:Osteocalcin / Q000097:blood; D010455:Peptides / Q000652:urine; D012306:Risk; D013131:Spine / Q000187:drug effects; D014807:Vitamin D / Q000097:blood / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D024042:Collagen Type I; D008293:Malates; D010455:Peptides; C052929:collagen type I trimeric cross-linked peptide; D015675:Osteocalcin; D014807:Vitamin D; D019343:Citric Acid; C083976:calcium citrate malate; D003094:Collagen; D002118:Calcium