In vitro sensitivity of Plasmodium falciparum to anti-folinic agents (trimethoprim, pyrimethamine, cycloguanil): a study of 29 African strains.
The in vitro drug sensitivity of three dihydrofolate reductase inhibitors (pyrimethamine, cycloguanil, trimethoprim) was determined against 29 strains and isolates of Plasmodium falciparum by an isotopic semi-microtest. Trimethoprim is less active than pyrimethamine or cycloguanil and its activity is correlated with that of two other inhibitors, suggesting cross-resistance in vitro among the dihydrofolate reductase inhibitors.
Basco
L K
LK
Centre national de référence de la chimiosensibilité du paludisme, Hôpital Bichat-Claude Bernard, Paris.
Le Bras
J
J
D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D016001:Confidence Intervals; D004351:Drug Resistance; D005493:Folic Acid Antagonists / Q000494:pharmacology*; D006801:Humans; D007928:Lethal Dose 50; D016778:Malaria, Falciparum / Q000469:parasitology; D017711:Nonlinear Dynamics; D010963:Plasmodium falciparum / Q000145:classification / Q000187:drug effects*; D002727:Proguanil; D011739:Pyrimethamine / Q000494:pharmacology*; D013762:Tetrahydrofolate Dehydrogenase / Q000187:drug effects; D014227:Triazines / Q000494:pharmacology*; D014295:Trimethoprim / Q000494:pharmacology*
D000962:Antimalarials; D005493:Folic Acid Antagonists; D014227:Triazines; C026009:cycloguanil; D014295:Trimethoprim; D013762:Tetrahydrofolate Dehydrogenase; D002727:Proguanil; D011739:Pyrimethamine