title: Gestational thyrotoxicosis manifesting as wernicke encephalopathy: a case report.
abstract: The thyroid gland is physiologically stimulated in normal early pregnancy. This stimulated thyroid function is occasionally termed "gestational transient thyrotoxicosis". The cause of this thyrotoxicosis has been clarified to closely it associate with human chorionic gonadotropin (hCG). We encountered a pregnant patient with hyperemesis and thyrotoxicosis, who manifested symptoms of Wernicke encephalopathy. Although her serum hCG concentration transiently increased in accordance with the thyrotoxicosis, it was within normal limits for the gestational week. Both the thyrotoxicosis and a catabolic state due to the hyperemesis were thought to have induced a vitamin B1 deficiency, causing the Wernicke encephalopathy. This case suggests that pregnant patients with hyperemesis should undergo careful endocrinological and neurological evaluations.
authors.affiliation: Department of Medicine III, Okayama University Medical School, Japan.
authors.forename: F
authors.initials: F
authors.lastname: Otsuka
authors.forename: K
authors.initials: K
authors.lastname: Tada
authors.forename: T
authors.initials: T
authors.lastname: Ogura
authors.forename: N
authors.initials: N
authors.lastname: Hayakawa
authors.forename: Y
authors.initials: Y
authors.lastname: Mimura
authors.forename: T
authors.initials: T
authors.lastname: Yamauchi
authors.forename: N
authors.initials: N
authors.lastname: Inoue
authors.forename: H
authors.initials: H
authors.lastname: Makino
authors.forename: T
authors.initials: T
authors.lastname: Kudo
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000627:therapeutic use; D007231:Infant, Newborn; D011247:Pregnancy; D011248:Pregnancy Complications; D011256:Pregnancy Outcome; D013831:Thiamine / Q000627:therapeutic use; D013832:Thiamine Deficiency / Q000188:drug therapy / Q000209:etiology; D013961:Thyroid Gland / Q000000981:diagnostic imaging; D013971:Thyrotoxicosis / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy; D014463:Ultrasonography; D014839:Vomiting / Q000150:complications; D014899:Wernicke Encephalopathy / Q000188:drug therapy / Q000209:etiology*
chemical_list: D006854:Hydrocortisone; D013831:Thiamine