Severe cutaneous and venous damage after DIC therapy.
A 79-year-old woman with skin ulcers caused by disseminated intravascular coagulation (DIC) therapy is reported. The patient had been treated by injection of drugs, including gabexate mesilate, into the right great saphenous vein. The maximum concentration of gabexate mesilate was calculated as 0.893%. Although the drugs did not extravasate, purpura initially appeared around the affected vein, followed by brown pigmentation with infiltration and ulcers with widely necrotic tissue from the middle portion of her thigh to the malleolus along her right great saphenous vein. As the ulcer showed no tendency to heal for more than 3 months, surgical debridement and skin grafts were performed.
Yuasa
T
T
Department of Dermatology, Mie University School of Medicine, Japan.
Taniguchi
Y
Y
Yamada
E
E
Inachi
S
S
Shimizu
M
M
D000368:Aged; D000925:Anticoagulants / Q000008:administration & dosage / Q000009:adverse effects*; D004211:Disseminated Intravascular Coagulation / Q000188:drug therapy*; D005260:Female; D016670:Gabexate / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D009336:Necrosis; D012501:Saphenous Vein / Q000187:drug effects / Q000473:pathology; D012883:Skin Ulcer / Q000139:chemically induced* / Q000473:pathology
D000925:Anticoagulants; D016670:Gabexate