Structure and function of the low conductance KATP channel, ROMK.
The renal ATP-sensitive low-conductance K+ channel (KATP) plays an important role in K+ recycling in the thick ascending limb and in K+ secretion in the collecting duct. The low-conductance KATP is stimulated by cAMP-dependent protein kinase A and inhibited by protein kinase C, arachidonic acid, acidic pH and sulfonylurea agents. We reviewed the progress concerning the properties of the recently cloned inward-rectifying K+ channel (ROMK or KirI) and compared their regulatory mechanisms with the native low-conductance KATP. The results are important to gain insight into molecular mechanisms by which ROMK channels are regulated.
Hebert
S C
SC
Department of Medicine, Vanderbilt University, Nashville, Tennessee, USA.
Wang
W H
WH
D000255:Adenosine Triphosphate / Q000502:physiology*; D000818:Animals; D002478:Cells, Cultured; D007686:Kidney Tubules, Distal / Q000502:physiology*; D011188:Potassium / Q000378:metabolism*; D015221:Potassium Channels / Q000502:physiology*; D011493:Protein Kinase C / Q000502:physiology; D011494:Protein Kinases / Q000502:physiology; D051381:Rats
D015221:Potassium Channels; D000255:Adenosine Triphosphate; D011494:Protein Kinases; D011493:Protein Kinase C; D011188:Potassium