title: Gastric emptying in patients with constipation following childbirth and due to idiopathic slow transit.
abstract: BACKGROUND
  Idiopathic slow transit constipation (ISTC) is considered to be a heterogeneous condition in which patients have varying sites and degrees of delayed gastrointestinal transit. The majority of patients have pancolonic disease, and colectomy with ileocolorectal anastomosis has been the mainstay of surgical treatment. Severe constipation following traumatic childbirth is now being recognized and this subgroup of patients may have delayed transit confined to the rectosigmoid colon. In theory, proximal transit in these patients should be normal.
  
  
  METHODS
  Gastric emptying was studied in patients with constipation following childbirth or ISTC and in controls. After an overnight fast, both patients and controls received breakfast, which consisted of cornflakes, sugar and milk. The liquid marker 111In-labelled di-ethylene tri-amine penta-acetic acid (DTPA) was added to the milk. A solid marker, 99mTc-labelled colloid, was impregnated on to paper and sealed with cellulose. The t1/2 for gastric emptying was calculated.
  
  
  RESULTS
  Liquid phase emptying was normal in both constipation following childbirth and ISTC. Solid phase emptying was delayed significantly in ISTC compared with that in patients with constipation following childbirth and controls. In addition, half the patients with ISTC had delayed transit through the small bowel and proximal colon. Small bowel and colonic transit were normal in patients with constipation following childbirth.
  
  
  CONCLUSIONS
  Patients with constipation following childbirth represent a distinct subgroup with normal proximal gastrointestinal function. Gastric emptying studies may be helpful in selecting patients for surgical management of severe constipation.
authors.affiliation: Department of Coloproctology, Royal Infirmary, Glasgow, UK.
authors.forename: A
authors.initials: A
authors.lastname: MacDonald
authors.forename: J N
authors.initials: JN
authors.lastname: Baxter
authors.forename: R G
authors.initials: RG
authors.lastname: Bessent
authors.forename: H W
authors.initials: HW
authors.lastname: Gray
authors.forename: I G
authors.initials: IG
authors.lastname: Finlay
mesh_terms: D000328:Adult; D003248:Constipation / Q000209:etiology / Q000503:physiopathology*; D005260:Female; D005746:Gastric Emptying / Q000502:physiology*; D005772:Gastrointestinal Transit / Q000502:physiology*; D006801:Humans; D007744:Obstetric Labor Complications / Q000503:physiopathology; D011247:Pregnancy; D011644:Puerperal Disorders / Q000209:etiology / Q000503:physiopathology*