title: Pathophysiological mechanisms underlying vasovagal syncope in young subjects.
abstract: The occurrence of vasovagal fainting is common in young subjects, but the origin of the precipitating hemodynamic mechanisms involved remain a subject of considerable speculation. Vasovagal fainting is not a sudden onset phenomenon, early failure of vascular resistance responses occurs in faint-prone young subjects. The variability of hemodynamic responses during the actual faint is large, but the main mechanism operative during, is withdrawal of sympathetic outflow to blood vessels in skeletal muscle with impairment of ability to maintain vasomotor tone.
authors.affiliation: Department of Internal Medicine, Academic Medical Centre, Amsterdam, The Netherlands.
authors.forename: W
authors.initials: W
authors.lastname: Wieling
authors.forename: A A
authors.initials: AA
authors.lastname: Smit
authors.forename: C C
authors.initials: CC
authors.lastname: de Jong-de Vos van Steenwijk
authors.forename: J J
authors.initials: JJ
authors.lastname: van Lieshout
authors.forename: J M
authors.initials: JM
authors.lastname: Karemaker
mesh_terms: D000293:Adolescent; D001794:Blood Pressure / Q000502:physiology; D001808:Blood Vessels / Q000294:innervation; D002302:Cardiac Output / Q000502:physiology; D002648:Child; D006339:Heart Rate / Q000502:physiology; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D018482:Muscle, Skeletal / Q000098:blood supply; D011187:Posture / Q000502:physiology; D013564:Sympathetic Nervous System / Q000503:physiopathology; D019462:Syncope, Vasovagal / Q000503:physiopathology*; D014655:Vascular Resistance / Q000502:physiology; D014661:Vasoconstriction; D014666:Vasomotor System / Q000503:physiopathology