CD36 autoantibodies and thrombotic diathesis, thrombocytopenia and repeated early fetal losses.
OBJECTIVE
Autoantibodies to CD36, a platelet glycoprotein, have been found in patients with thrombotic thrombocytopenic purpura, and in those with lupus-like anticoagulant with thrombotic complications.


METHODS
Conventional hematologic and laboratory methods were used. The patient was a pregnant woman, who had had two early fetal losses separated by a normal offspring. Despite severe thrombocytopenia, she was asymptomatic.


RESULTS
Serological investigations were strongly suggestive of CD36 autoantibodies. Neither clinical nor laboratory data were typical of those usually associated with cd36 autoantibodies, namely thrombotic thrombocytopenic purpura (TTP), systemic lupus erythematosis (SLE), or prothrombotic compliance. Prophylaxis with salicylates and prednisone was started at the 8th week of gestation, and an offspring with mild thrombocytopenia was delivered by cesarean section at the 32nd week of gestation because of abruptio placentae.


CONCLUSIONS
There may be a cause-and-effect relationship between early fetal losses and CD36 autoantibodies.
Borzini
P
P
Servizio Immunotransfusionalc, Ospedale San Gerardo, Monza, Italia.
Riva
M
M
Nembri
P
P
Rossi
E
E
Pagliaro
P
P
Vergani
P
P
Greppi
P
P
Tantardini
P
P
D000026:Abortion, Habitual / Q000276:immunology*; D000328:Adult; D001323:Autoantibodies / Q000097:blood*; D018955:CD36 Antigens / Q000276:immunology*; D004198:Disease Susceptibility / Q000276:immunology; D005260:Female; D006801:Humans; D016682:Lupus Coagulation Inhibitor / Q000276:immunology; D011247:Pregnancy; D011697:Purpura, Thrombotic Thrombocytopenic / Q000276:immunology*; D013927:Thrombosis / Q000276:immunology*
D001323:Autoantibodies; D018955:CD36 Antigens; D016682:Lupus Coagulation Inhibitor