Effect of infusion regime on doxorubicin pharmacokinetics in the cat.
In the pharmacokinetic evaluation of a single doxorubicin dose calculated by body surface area (25 mg/m2) or body weight (1 mg/kg body weight) and given intravenously as a 10-, 15-, or 20-minute infusion, the rate of doxorubicin infusion (mg per minute per m2 or mg per minute per kg) correlated positively with clearance and the distribution rate constant alpha, and it inversely correlated with area under the plasma concentration versus time curve (AUC). These findings suggest that a slower infusion rate results in a greater AUC and longer distribution phase than a faster infusion rate and indicates the importance of normalizing dosage regimes by infusion rate rather than by infusion duration when considering dose-response phenomena in veterinary patients.
Hahn
K A
KA
Department of Comparative Medicine, College of Veterinary Medicine, University of Tennessee, Knoxville 37901-1071, USA.
Frazier
D L
DL
Cox
S K
SK
Legendre
A M
AM
D000230:Adenocarcinoma / Q000188:drug therapy / Q000378:metabolism / Q000662:veterinary; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage* / Q000493:pharmacokinetics* / Q000627:therapeutic use; D019540:Area Under Curve; D001830:Body Surface Area; D001835:Body Weight / Q000502:physiology; D002371:Cat Diseases / Q000188:drug therapy / Q000378:metabolism* / Q000503:physiopathology; D002415:Cats; D004305:Dose-Response Relationship, Drug; D004317:Doxorubicin / Q000008:administration & dosage* / Q000493:pharmacokinetics* / Q000627:therapeutic use; D005260:Female; D005354:Fibrosarcoma / Q000188:drug therapy / Q000378:metabolism / Q000662:veterinary; D007262:Infusions, Intravenous / Q000662:veterinary; D015674:Mammary Neoplasms, Animal / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy / Q000378:metabolism / Q000662:veterinary; D012983:Soft Tissue Neoplasms / Q000188:drug therapy / Q000378:metabolism / Q000662:veterinary*; D013997:Time Factors
D000903:Antibiotics, Antineoplastic; D004317:Doxorubicin