title: Nontasters, tasters, and supertasters of 6-n-propylthiouracil (PROP) and hedonic response to sweet.
abstract: Genetic sensitivity to 6-n-propylthiouracil (PROP) has been reported to predict hedonic response to sweet taste in both women and men. This study was based on a sample of 159 women of different ethnic backgrounds, mean age 27.0 years, and mean body mass index (BMI) 23.2. The women were classified as nontasters (n = 43), regular tasters (n = 70), or supertasters (n = 46) of PROP on the basis of their PROP detection thresholds and the scaling of 5 suprathreshold solutions of PROP and NaCl. Nontasters had thresholds > 1.8 x 10(-4) mol/L PROP and PROP/NaCl ratios < 1.60. Supertasters had thresholds < 3.2 x 10(-5) mol/L PROP and PROP/NaCl ratios > 1.60. Genetic sensitivity to PROP failed to predict sweetness intensity ratings or hedonic response profiles for sucrose solutions. Separating subjects into sucrose "likers" and "dislikers" failed to reveal any significant links to PROP nontaster, taster, or supertaster status in this all-female sample.
authors.affiliation: Human Nutrition Program, School of Public Health II, The University of Michigan, Ann Arbor 48109-2029, USA.
authors.forename: A
authors.initials: A
authors.lastname: Drewnowski
authors.forename: S A
authors.initials: SA
authors.lastname: Henderson
authors.forename: A B
authors.initials: AB
authors.lastname: Shore
authors.forename: A
authors.initials: A
authors.lastname: Barratt-Fornell
mesh_terms: D000328:Adult; D000963:Antimetabolites / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D010684:Philosophy; D011441:Propylthiouracil / Q000494:pharmacology*; D012684:Sensory Thresholds / Q000502:physiology; D013395:Sucrose / Q000494:pharmacology*; D013649:Taste / Q000187:drug effects* / Q000502:physiology
chemical_list: D000963:Antimetabolites; D013395:Sucrose; D011441:Propylthiouracil