title: Trypanocidal flavonoids from Trixis vauthieri.
abstract: The crude extract of Trixis vauthieri (Asteraceae) was active against the trypomastigote forms of Trypanosoma cruzi, the protozoan that causes Chagas' disease. Bioassay-guided fractionation of this extract afforded the trypanocidal flavonoids 5,4'-dihydroxy-7-methoxyflavanone (1) and 5,4'-dihydroxy-3,6,7-trimethoxyflavone (2) besides the inactive flavonoids 3,5,4'-trihydroxy-7-methoxyflavanone (3) and 5,4'-dihydroxy-3,6,7,8-tetramethoxy flavone (4). The trypanocidal activity of 1 and 2 and the presence of compounds 2 and 4 in Trixis vauthieri are reported here for the first time.
authors.affiliation: Departamento de Química-ICEx-UFMG, Belo Horizonte, MG, Brazil.
authors.forename: A
authors.initials: A
authors.lastname: Ribeiro
authors.forename: D
authors.initials: D
authors.lastname: Piló-Veloso
authors.forename: A J
authors.initials: AJ
authors.lastname: Romanha
authors.forename: C L
authors.initials: CL
authors.lastname: Zani
mesh_terms: D000818:Animals; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D051379:Mice; D015394:Molecular Structure; D010944:Plants / Q000737:chemistry*; D014344:Trypanocidal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D014349:Trypanosoma cruzi / Q000187:drug effects
chemical_list: D005419:Flavonoids; D014344:Trypanocidal Agents