[Immobilized proteases and their activators as immunocorrective agents].
The influence of immobilized proteases such as catalytin (a complex preparation containing the protease terrilytin and the antiseptic catapol) and streptodecase (an activator of fibrinolysis proteases) on the humoral immune response induced by the thymus-dependent antigen (SRBC) under conditions of burns and Staphylococcus infected burns was studied. The immobilized proteases catalytin and streptodecase had an immunostimulating effect under conditions of extended burns. Catalytin had an immunocorrigating effect under conditions of the infected burns. It was suggested that the complex enzyme-containing preparation catalytin and the immobilized activator of fibrinolysis proteases streptodecase were promising immunopharmacological agents in combined treatment of pathological processes accompanied by the development of immune deficiency as a secondary condition.
Khmelevskaia
I G
IG
Ragulina
V A
VA
Konoplia
A I
AI
Chalyĭ
G A
GA
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000681:Amylases / Q000627:therapeutic use*; D000818:Animals; D000891:Anti-Infective Agents, Local; D002056:Burns / Q000276:immunology* / Q000382:microbiology; D004789:Enzyme Activation; D004800:Enzymes, Immobilized / Q000627:therapeutic use*; D005343:Fibrinolytic Agents / Q000494:pharmacology*; D007108:Immune Tolerance / Q000187:drug effects; D010447:Peptide Hydrolases / Q000627:therapeutic use*; D000644:Quaternary Ammonium Compounds / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D013203:Staphylococcal Infections / Q000276:immunology; D013300:Streptokinase / Q000494:pharmacology*
D000276:Adjuvants, Immunologic; D000891:Anti-Infective Agents, Local; D004800:Enzymes, Immobilized; D005343:Fibrinolytic Agents; D000644:Quaternary Ammonium Compounds; C107177:catalytin; C031490:catamine AB; D000681:Amylases; D010447:Peptide Hydrolases; D013300:Streptokinase