[Organ cytotoxicity of selected polycyclic aromatic hydrocarbons in mice].
The cytotoxic effects of some PAHs: DMBA, 3-MC and B(a)P on the lymphatic organs, liver and kidney of mice have been investigated. These PAHs in doses of 100 mg/kg were dissolved in 0.5 ml 20% DMSO and were given intraperitoneally in female mice Balb/c. After 7 days, organs weight, cellularity in lymphoid organs and tissue structure of liver and kidney were analyzed. The greatest effect of DMBA was observed on cellularity of spleen. 3-MC and B(a)P caused significant hepatotoxic and nephrotoxic changes. 3-MC induced focal destruction of hepatocytes and sometimes--irregular mitotic figures (c-mitosis). After B(a)P administration in liver cells were mainly observed the changes in distribution of interphase nucleolar organizer region (AgNOR). In kidney--irregular glomeruli and tubuli after 3-MC and B(a)P were noted. The above results may indicate that the cytotoxic effects of PAHs depend on the type of compound administered.
Izdebska-Szymona
K
K
Zakład Immunologii Uniwersytetu Warszawskiego Kierownik.
Kopeć-Szlezak
J
J
Kozłowska
E
E
Drela
N
N
Pańczyk
S
S
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000633:toxicity*; D000818:Animals; D001564:Benzo(a)pyrene / Q000633:toxicity*; D002273:Carcinogens / Q000633:toxicity*; D004121:Dimethyl Sulfoxide / Q000633:toxicity; D005260:Female; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008221:Lymphoid Tissue / Q000187:drug effects / Q000473:pathology; D008748:Methylcholanthrene / Q000633:toxicity*; D051379:Mice; D008807:Mice, Inbred BALB C; D009697:Nucleolus Organizer Region / Q000473:pathology; D009929:Organ Size / Q000187:drug effects; D011083:Polycyclic Compounds / Q000633:toxicity*
D002273:Carcinogens; D011083:Polycyclic Compounds; D001564:Benzo(a)pyrene; D008748:Methylcholanthrene; D015127:9,10-Dimethyl-1,2-benzanthracene; D004121:Dimethyl Sulfoxide