title: Development of a non-pulsatile permanent rotary blood pump.
abstract: For many years, a common belief was that non-pulsatile perfusion produced physiological and circulatory abnormalities. Since 1977 our group has reported, if a 20% higher blood flow was used more than required for a pulsatile blood pump, there would be no circulatory or physiological abnormalities. These experimental findings confirmed that there was no difference in clinical outcome when using a pulsatile or non-pulsatile blood pump. Furthermore, the non-pulsatile rotary blood pump has demonstrated efficient and reliable performance in various clinical situations. The non-pulsatile blood pump is a simple and reliable design, that can be easily manufactured, and has the following desirable features. There is no need to incorporate heart valves, a large orifice inflow conduit, or a compliance volume-shifting chamber. Since an electrical motor operates continuously, the on-and-off motion required for a pulsatile pump is not necessary; therefore, it becomes a more efficient and durable system. Further, the control algorism is simpler and more reliable than a pulsatile pump. Considering these factors, the non-pulsatile blood pump can be selected for a permanently implantable assist device. To develop an implantable non-pulsatile cardiac device, it is necessary to incorporate seven features in the system such as: small size, atraumatic features, anti-thrombogenic features, anti-infection features, durable and simple design, and low energy requirement with easy controllability.
authors.affiliation: Baylor College of Medicine, Department of Surgery, Houston, TX 77030, USA.
authors.forename: Y
authors.initials: Y
authors.lastname: Nose
authors.forename: K
authors.initials: K
authors.lastname: Kawahito
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena; D001783:Blood Flow Velocity; D002417:Cattle; D004560:Electricity; D004867:Equipment Design; D006353:Heart-Assist Devices; D011673:Pulsatile Flow