title: Afferent projection patterns in the auditory brainstem in normal and congenitally deaf white cats.
abstract: Cochlear implantation in congenitally deaf children is developing to a successful medical tool. Little is known, however, on morphology and pathophysiology of the central auditory system in these auditory deprived children. One form of congenital hearing loss, that seen in the deaf white cat, was investigated to see if there are differences in the afferent pathways from the cochlear nuclei to the inferior colliculus. The retrogradely transported fluorescent tracer diamidino yellow (DY) was injected into different parts of the central nucleus of the inferior colliculus (ICC) of normal cats and deaf white cats. It was found that the main afferent projection patterns in deaf white cats were unchanged in spite of congenital auditory deprivation; minor differences were seen.
authors.affiliation: Physiologisches Institut III, J.W. Goethe-Universität, Frankfurt/Main,Germany. klinke@em.uni-frankfurt.de
authors.forename: S
authors.initials: S
authors.lastname: Heid
authors.forename: T K
authors.initials: TK
authors.lastname: Jähn-Siebert
authors.forename: R
authors.initials: R
authors.lastname: Klinke
authors.forename: R
authors.initials: R
authors.lastname: Hartmann
authors.forename: G
authors.initials: G
authors.lastname: Langner
mesh_terms: D000578:Amidines; D000818:Animals; D002415:Cats; D003054:Cochlear Implants; D017626:Cochlear Nucleus / Q000002:abnormalities / Q000503:physiopathology; D003638:Deafness / Q000151:congenital / Q000503:physiopathology*; D004195:Disease Models, Animal; D016057:Evoked Potentials, Auditory, Brain Stem / Q000502:physiology*; D005260:Female; D005456:Fluorescent Dyes; D007245:Inferior Colliculi / Q000002:abnormalities / Q000503:physiopathology; D008297:Male; D009475:Neurons, Afferent / Q000473:pathology*; D009925:Organ of Corti / Q000002:abnormalities
chemical_list: D000578:Amidines; D005456:Fluorescent Dyes; C037945:diamidino yellow