Protein tyrosine kinases in thymocyte development.
Much has been learned over the past few years about how protein tyrosine kinases mediate pre-TCR and mature alphabetaTCR function. The highlights include understanding the roles and the distinct effects of the Src and Syk families of protein tyrosine kinases in thymocyte development and function.
Cheng
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AM
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, M5G 1X5, Canada.
Chan
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AC
D000818:Animals; D002454:Cell Differentiation; D004792:Enzyme Precursors / Q000502:physiology; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D008213:Lymphocyte Activation; D008954:Models, Biological; D010766:Phosphorylation; D011499:Protein Processing, Post-Translational; D011505:Protein-Tyrosine Kinases / Q000502:physiology*; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000276:immunology; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000276:immunology; D015398:Signal Transduction; D000072377:Syk Kinase; D013601:T-Lymphocytes / Q000166:cytology*; D013950:Thymus Gland / Q000166:cytology / Q000201:enzymology*; D019061:src-Family Kinases / Q000502:physiology
D004792:Enzyme Precursors; D047908:Intracellular Signaling Peptides and Proteins; D016693:Receptors, Antigen, T-Cell, alpha-beta; D016692:Receptors, Antigen, T-Cell, gamma-delta; D011505:Protein-Tyrosine Kinases; C000606896:SYK protein, human; D000072377:Syk Kinase; D019061:src-Family Kinases