title: Multifocal Aspergillus terreus discospondylitis in two German shepherd dogs.
abstract: Multifocal fungal (Aspergillus terreus) discospondylitis was diagnosed in 2 German shepherd dogs. In one dog, the aetiology was established by means of fluoroscopic-guided disc aspiration, cytology and culture of disc material and urine. Disseminated aspergillosis was confirmed at necropsy and A. terreus cultured from numerous organs in this dog. The aetiology in the other dog was not established until therapeutic failure forced surgical curettage of disc material from which the fungus was cultured. Ketoconazole therapy failed to effect an improvement, and at necropsy, disease was localised to the spinal column, with A. terreus cultured from the affected discs and associated vertebrae. Immunodeficiency was suspected in both cases. In the case of disseminated disease a reduced lymphocyte blastogenic response was demonstrated. Reduced IgA was shown in both cases. The German shepherd breed seems to be predisposed to Aspergillus infections and IgA deficiency.
authors.affiliation: Department of Medicine, Faculty of Veterinary Science, University of Pretoria, South Africa.
authors.forename: W L
authors.initials: WL
authors.lastname: Berry
authors.forename: A L
authors.initials: AL
authors.lastname: Leisewitz
mesh_terms: D000658:Amoxicillin / Q000627:therapeutic use; D000818:Animals; D000935:Antifungal Agents / Q000627:therapeutic use; D001228:Aspergillosis / Q000175:diagnosis / Q000188:drug therapy / Q000662:veterinary*; D001230:Aspergillus / Q000302:isolation & purification; D002574:Cervical Vertebrae; D002969:Clavulanic Acids / Q000627:therapeutic use; D015299:Discitis / Q000175:diagnosis / Q000188:drug therapy / Q000662:veterinary*; D004283:Dog Diseases / Q000175:diagnosis* / Q000188:drug therapy; D004285:Dogs; D004359:Drug Therapy, Combination; D005260:Female; D017098:IgA Deficiency / Q000662:veterinary; D007654:Ketoconazole / Q000627:therapeutic use; D013904:Thoracic Vertebrae
chemical_list: D000935:Antifungal Agents; D002969:Clavulanic Acids; D000658:Amoxicillin; D007654:Ketoconazole