title: Angiotropic lymphoma with endocrine involvement.
abstract: OBJECTIVE
  Two cases of angiotropic high-grade B-cell lymphoma are described in which involvement of endocrine glands was a prominent feature.
  
  
  RESULTS
  One patient had marked unilateral adrenomegally due to lymphoma within adrenal blood vessels. He is alive 5 years after presentation following combination chemotherapy. The diagnosis was made at autopsy in the second patient who presented with pyrexia of unknown origin and had hypothyroidism and a thyroid nodule. The thyroid gland and pituitary showed striking involvement by angiotropic lymphoma and the thyroid nodule was a cavernous haemangioma heavily colonized by lymphoma cells.
  
  
  CONCLUSIONS
  Our cases illustrate endocrine organ manifestations of this rare disease. The condition may respond to combination chemotherapy.
authors.affiliation: Department of Histopathology, Christie Hospital, Manchester, UK.
authors.forename: J H
authors.initials: JH
authors.lastname: Shanks
authors.forename: M
authors.initials: M
authors.lastname: Harris
authors.forename: A J
authors.initials: AJ
authors.lastname: Howat
authors.forename: A J
authors.initials: AJ
authors.lastname: Freemont
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000473:pathology* / Q000503:physiopathology; D000368:Aged; D001808:Blood Vessels / Q000473:pathology*; D005260:Female; D006801:Humans; D008223:Lymphoma / Q000473:pathology* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D013964:Thyroid Neoplasms / Q000473:pathology* / Q000503:physiopathology