title: Induction and duration of long-term potentiation in the hippocampus of the freely moving mouse.
abstract: We describe a simple method, using readily available minaturised components, for inducing and monitoring long-term potentiation (LTP) at perforant path-granule cell synapses in the dentate gyrus of the freely moving mouse. Tetanic stimulation induced LTP of the field EPSP and the population spike which persisted for more than 24 h but was not present 10 days after the tetanus. The potentiation of the population spike was proportionately greater than the potentiation of the EPSP (E-S potentiation). Induction of LTP was blocked by intraperitoneal injections of the N-methyl-D-aspartate (NMDA) receptor antagonist, 3-((RS)-2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid (CPP).
authors.affiliation: Laboratoire de Neurobiologie de l'Apprentissage et de la Mémoire, CNRS, URA 1491, Université Paris Sud, Orsay, France. Sabrina.Davis@ibaic.u-psud.Fr
authors.forename: S
authors.initials: S
authors.lastname: Davis
authors.forename: T V
authors.initials: TV
authors.lastname: Bliss
authors.forename: G
authors.initials: G
authors.lastname: Dutrieux
authors.forename: S
authors.initials: S
authors.lastname: Laroche
authors.forename: M L
authors.initials: ML
authors.lastname: Errington
mesh_terms: D000818:Animals; D018891:Dentate Gyrus / Q000502:physiology*; D004558:Electric Stimulation; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology; D007274:Injections, Intraperitoneal; D017774:Long-Term Potentiation / Q000187:drug effects; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D009068:Movement / Q000502:physiology*; D010879:Piperazines / Q000494:pharmacology; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors
chemical_list: D018691:Excitatory Amino Acid Antagonists; D010879:Piperazines; D016194:Receptors, N-Methyl-D-Aspartate; C065286:SDZ EAA 494