[Bio-antioxidant activity of 3,5-di-tert-butylpyrocatechol and its influence on hypoxia, inflammation, pain and burns].
The bioantioxidant activity of the synthesized by us on the base of the diatomic phenol compound--3,5-di-t-butylpyrocatechol--has been studied. It was shown that this substance exhibits more pronounced antioxidant properties than tocopherol on the lipid peroxidation process in the rat brain homogenate appears in concentrations right up to 10(-8)-10(-7) M. Antioxidant effect of 3,5-di-t-butylpyrocatechol protecting action correlation has been found in the simulation of such pathological organism states as hypoxia, inflammation, burn, pain. All above mentioned results confirms the expedience of search for new drugs based on diatomic phenols.
Shadyro
O I
OI
Belorussian State University, Minsk.
Shilov
G N
GN
Timoshchuk
V A
VA
Vlasova
V I
VI
Fedulov
A S
AS
Mezen
N I
NI
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D002056:Burns / Q000188:drug therapy* / Q000378:metabolism; D002084:Butylated Hydroxytoluene / Q000494:pharmacology; D003510:Cyclohexanes / Q000494:pharmacology*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D000860:Hypoxia / Q000188:drug therapy* / Q000378:metabolism; D007249:Inflammation / Q000188:drug therapy* / Q000378:metabolism; D007274:Injections, Intraperitoneal; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D051379:Mice; D010146:Pain / Q000188:drug therapy* / Q000378:metabolism; D051381:Rats; D016896:Treatment Outcome; D014810:Vitamin E / Q000494:pharmacology
D000975:Antioxidants; D003510:Cyclohexanes; D014810:Vitamin E; D002084:Butylated Hydroxytoluene; C067220:di-tert-butylperoxy-3,3,5-trimethylcyclohexane peroxide