title: Killing two birds with one stone: a chemically plausible scheme for linked nucleic acid replication and coded peptide synthesis.
abstract: To understand how life began, we must explain the origins of nucleic acid replication and genetically coded peptide synthesis. Neither of these is easy to explain individually; here, we propose a chemically plausible scheme for the evolution of a process that simultaneously produced both polymers. Later, two separate machineries could have evolved from the linked process.
authors.affiliation: Dyson Perrins Laboratory, Oxford, UK. john.sutherland@dpl.ox.ac.uk
authors.forename: J D
authors.initials: JD
authors.lastname: Sutherland
authors.forename: J M
authors.initials: JM
authors.lastname: Blackburn
mesh_terms: D004261:DNA Replication; D019143:Evolution, Molecular; D012313:RNA / Q000096:biosynthesis*
chemical_list: D012313:RNA