Fine mapping of a genetic locus for Peutz-Jeghers syndrome on chromosome 19p.
Peutz-Jeghers syndrome (PJS) was recently mapped in a single report to the telomeric region of chromosome 19p (A. Hemminki et al., Nat. Genet., 15: 87-90, 1997). Our studies confirm this location and provide further localization of the PJS locus. In the five families examined, there were no recombinants with the marker D19S886. The multipoint log odds score at D19S886 is 7.52, and we found no evidence for genetic heterogeneity. We also found that all carriers expressed the PJS phenotype and no noncarriers displayed PJS sequellae, indicating complete penetrance with no sporadic cases.
Amos
C I
CI
Department of Epidemiology, University of Texas M.D. Anderson Cancer Center, Houston 77030, USA.
Bali
D
D
Thiel
T J
TJ
Anderson
J P
JP
Gourley
I
I
Frazier
M L
ML
Lynch
P M
PM
Luchtefeld
M A
MA
Young
A
A
McGarrity
T J
TJ
Seldin
M F
MF
D002874:Chromosome Mapping / Q000379:methods*; D002888:Chromosomes, Human, Pair 19 / Q000235:genetics*; D005260:Female; D005819:Genetic Markers; D006579:Heterozygote; D006801:Humans; D008126:Lod Score; D008297:Male; D010375:Pedigree; D010580:Peutz-Jeghers Syndrome / Q000235:genetics*; D010641:Phenotype
D005819:Genetic Markers