[A therapeutic trial in Giardia muris infection in the mouse with metronidazole, tinidazole, secnidazole and furazolidone].
A comparative study about the effectiveness of metronidazole, tinidazole, secnidazole and furazolidone was performed on Giardia muris from mice naturally infected. Groups of 12 animals each was constituted: the control treated with saline; one treated with metronidazole; one treated with furazolidone; one treated with tinidazole; one treated with secnidazole; histological normal control; histological infected. Samples of three stools were examined before and after treatment with quantification of cysts. Animals were cured when the trophozoites was not seen in the small bowel. The curative activity of drugs was 58.3% for metronidazole, 50% for furazolidone, 40% for secnidazole and 16% for tinidazole. It was also showed that there was a different pattern of the intestinal mucosa from the control and infected groups, treated or not, suggesting that the alterations encountered in the mucosa of infected animals were due to the parasitism either the action of the drugs.
Cruz
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CC
Departamento de Parasitologia, Universidade Estadual Paulista (UNESP), Botucatu, SP.
Ferrari
L
L
Sogayar
R
R
D000818:Animals; D000981:Antiprotozoal Agents / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D005243:Feces / Q000469:parasitology; D005664:Furazolidone / Q000627:therapeutic use*; D005873:Giardiasis / Q000188:drug therapy* / Q000469:parasitology / Q000473:pathology; D007413:Intestinal Mucosa / Q000469:parasitology / Q000473:pathology; D008297:Male; D008795:Metronidazole / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D051379:Mice; D014011:Tinidazole / Q000627:therapeutic use*
D000981:Antiprotozoal Agents; D014011:Tinidazole; D008795:Metronidazole; D005664:Furazolidone; C016724:secnidazole