Stabilization of protein structures.
The technique of protein stabilization has been improving steadily in recent years, but it is only in the past year or two that the stability of some protein molecules has been improved to the level of those from extreme thermophilic organisms. This was achieved by multiple mutations and often by utilizing the knowledge gained from the homologous protein structures from extreme thermophiles.
Lee
B
B
Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4255, USA.
Vasmatzis
G
G
D000818:Animals; D001419:Bacteria; D002151:Calorimetry; D004355:Drug Stability; D006358:Hot Temperature; D006801:Humans; D015202:Protein Engineering; D011506:Proteins / Q000737:chemistry*; D011994:Recombinant Proteins / Q000737:chemistry*
D011506:Proteins; D011994:Recombinant Proteins