Cardiopulmonary and anesthetic effects of propofol in wild turkeys.
OBJECTIVE
To determine safety, anesthetic variables, and cardiopulmonary effects of i.v. infusion of propofol for induction and maintenance of anesthesia in wild turkeys.


METHODS
10 healthy, adult wild turkeys.


METHODS
Anesthesia was induced by i.v. administration of propofol (5 mg/kg of body weight) over 20 seconds and was maintained for 30 minutes by constant i.v. infusion of propofol at a rate of 0.5 mg/kg/min. Heart and respiratory rates, arterial blood pressures, and arterial blood gas tensions were obtained prior to propofol administration (baseline values) and again at 1, 2, 3, 4, 5, 10, 15, 20, 25, and 30 minutes after induction of anesthesia. All birds were intubated immediately after induction of anesthesia, and end-tidal CO2 concentration was determined at the same time intervals. Supplemental oxygen was not provided.


RESULTS
Apnea was observed for 10 to 30 seconds after propofol administration, which induced a decrease in heart rate; however, the changes were not significant. Compared with baseline values, respiratory rate was significantly decreased at 4 minutes after administration of propofol and thereafter. Systolic, mean, and diastolic pressures decreased over the infusion period, but the changes were not significant. Mean arterial blood pressure decreased by 30% after 15 minutes of anesthesia; end-tidal CO2 concentration increased from baseline values after 30 minutes; PO2 was significantly decreased at 5 minutes after induction and thereafter; PCO2 was significantly (P < 0.05) increased after 15 minutes of anesthesia; and arterial oxygen saturation was significantly (P < 0.05) decreased at the end of anesthesia. Two male turkeys developed severe transient hypoxemia, 1 at 5 and the other at 15 minutes after induction. Time to standing after discontinuation of propofol infusion was 11 +/- 6 minutes. Recovery was smooth and unremarkable.


CONCLUSIONS
Propofol is an effective agent for i.v. induction and maintenance of anesthesia in wild turkeys, and is useful for short procedures or where the use of inhalational agents is contraindicated.
Schumacher
J
J
Department of Small Animal Clinical Sciences College of Veterinary Medicine, University of Florida, Gainesville 32610, USA.
Citino
S B
SB
Hernandez
K
K
Hutt
J
J
Dixon
B
B
D000771:Anesthesia, Intravenous / Q000662:veterinary*; D018686:Anesthetics, Intravenous / Q000494:pharmacology*; D000818:Animals; D000829:Animals, Domestic; D000835:Animals, Wild; D001794:Blood Pressure / Q000187:drug effects*; D002245:Carbon Dioxide / Q000097:blood; D005260:Female; D006339:Heart Rate / Q000187:drug effects*; D006863:Hydrogen-Ion Concentration; D007262:Infusions, Intravenous; D008297:Male; D010100:Oxygen / Q000097:blood; D010313:Partial Pressure; D015742:Propofol / Q000008:administration & dosage / Q000494:pharmacology*; D012119:Respiration / Q000187:drug effects*; D014422:Turkeys
D018686:Anesthetics, Intravenous; D002245:Carbon Dioxide; D010100:Oxygen; D015742:Propofol