A CT using longitudinally detected ESR (LODESR-CT) of intraperitoneally injected nitroxide radical in a rat's head.
We have developed an in vivo longitudinally detected ESR (LODESR) imaging system operating at 700 MHz based on a loop-gap resonator and a pair of saddle-type pickup coils. A good linear relationship between the LODESR signal intensity and the applied power in a range up to 15.8 W was obtained. The detection of LODESR signals was barely affected by variations in the resonant properties. The characteristic of LODESR is suitable for in vivo examination. Using this system, we succeeded in obtaining LODESR-CT images of the head region of a rat after the intraperitoneal injection of a nitroxide radical.
Yokoyama
H
H
Institute for Life Support Technology, Yamagata Technopolis Foundation, Japan.
Sato
T
T
Tsuchihashi
N
N
Ogata
T
T
Ohya-Nishiguchi
H
H
Kamada
H
H
D000818:Animals; D001921:Brain / Q000033:anatomy & histology*; D003497:Cyclic N-Oxides / Q000008:administration & dosage; D004578:Electron Spin Resonance Spectroscopy / Q000379:methods*; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D007274:Injections, Intraperitoneal; D008297:Male; D011759:Pyrrolidines / Q000008:administration & dosage; D011837:Radiation-Protective Agents / Q000008:administration & dosage; D051381:Rats; D017208:Rats, Wistar
D003497:Cyclic N-Oxides; D011759:Pyrrolidines; D011837:Radiation-Protective Agents; C077426:3-carbamoyl-2,2,5,5-tetramethyl-1-pyrrolidinyl-N-oxyl