title: Global volumetric estimation of disease burden in multiple sclerosis based on magnetization transfer imaging.
abstract: We report a semiautomated postprocessing method based on magnetization transfer MR imaging that can quantify the extent of global disease in patients with multiple sclerosis. The technique combines segmentation and quantitative analysis of imaging data reflecting the structural integrity of white matter. Applications of this technique may include assessment of disease progress and of the efficacy of experimental therapeutic intervention. The height of the histogram peak corresponding to white matter was found to be lowered in patients with multiple sclerosis and the overall distribution of magnetization transfer ratios was shifted to lower values.
authors.affiliation: Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia 19104, USA.
authors.forename: M A
authors.initials: MA
authors.lastname: van Buchem
authors.forename: J K
authors.initials: JK
authors.lastname: Udupa
authors.forename: J C
authors.initials: JC
authors.lastname: McGowan
authors.forename: Y
authors.initials: Y
authors.lastname: Miki
authors.forename: F H
authors.initials: FH
authors.lastname: Heyning
authors.forename: M P
authors.initials: MP
authors.lastname: Boncoeur-Martel
authors.forename: D L
authors.initials: DL
authors.lastname: Kolson
authors.forename: M
authors.initials: M
authors.lastname: Polansky
authors.forename: R I
authors.initials: RI
authors.lastname: Grossman
mesh_terms: D000328:Adult; D001921:Brain / Q000473:pathology; D005260:Female; D006801:Humans; D007089:Image Enhancement; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000145:classification / Q000175:diagnosis* / Q000628:therapy; D009413:Nerve Fibers, Myelinated / Q000473:pathology; D012016:Reference Values; D016896:Treatment Outcome