title: [What is the current age and sex-related cadmium burden of the human kidney cortex?].
abstract: 55 persons of either sex in the age bracket between 0.02 and 87 years had to be examined by experts in forensic medicine. In these examinations, slices of kidney cortex were removed and prepared for cadmium(Cd)-determination by atomic absorption spectrophotometry. The samples were wet ashed by a special and quick method developed in our laboratory, using concentrated (65%) HNO3 for a short period of 1 hour at 90 degrees C. The main results of the present study were that Cd accumulation in the kidney cortex was delayed in the age group between 0.02 and 40 years. The highest Cd concentration of 27 micrograms/g wet weight was found in the age group between 50-59 years. In persons of higher age, above 60 years, the Cd concentrations were generally lower than in persons of the age group between 50-59 years; however, this decline does not seem to be significant. Summing up, we can say that the delayed increase in Cd concentrations in the kidney cortex of persons in the age group between 0.02 and 40 years might be regarded as the first positive result of the restrictive use of Cd materials, resulting in food intake with lower Cd contamination. The present study should be repeated after about 5 years to confirm whether this hopeful assumption is true.
authors.affiliation: Institut für Toxikologie, Klinikum der Christian-Albrechts-Universität zu Kiel.
authors.forename: S
authors.initials: S
authors.lastname: Mai
authors.forename: C
authors.initials: C
authors.lastname: Alsen-Hinrichs
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001822:Body Burden; D002104:Cadmium / Q000032:analysis*; D002105:Cadmium Poisoning / Q000453:epidemiology*; D002648:Child; D002675:Child, Preschool; D004784:Environmental Monitoring / Q000706:statistics & numerical data*; D062665:Epidemiological Monitoring; D005260:Female; D005858:Germany / Q000453:epidemiology; D006801:Humans; D007223:Infant; D007672:Kidney Cortex / Q000737:chemistry*; D008297:Male; D008875:Middle Aged; D012737:Sex Factors
chemical_list: D002104:Cadmium