title: [An analysis of causes of recurrence, matastasis and death of retinoblastoma].
abstract: OBJECTIVE
  To discuss the relationship between diagnosis, treatment and recurrence, metastasis, death of Rb patients.
  
  
  METHODS
  To analyse the data of 46 Rb patients treated in our center from July 1967 to May 1992, who had either recurrence, metastasis or died.
  
  
  RESULTS
  The main factors affecting Rb prognosis are: 1 early or late diagnosis: 2 the mortality rate increased with the degree of optic nerve involvement: 3 involvement of orbit, cranial cavity and choroid by Rb; 4 clinically, secondary glaucoma often accompanied by optic nerve involvement.
  
  
  CONCLUSIONS
  Delay in diagnosis and treatment will result in Rb recurrence, metastasis and death. Early diagnosis and treatment is very important for survival rate.
authors.affiliation: Zhongshan Ophthalmic Center, Sun Yat-sen University of Medical Sciences, Guangzhou, China.
authors.forename: Z
authors.initials: Z
authors.lastname: Chen
authors.forename: Z
authors.initials: Z
authors.lastname: Wu
authors.forename: G
authors.initials: G
authors.lastname: Feng
authors.forename: Y
authors.initials: Y
authors.lastname: Pang
authors.forename: Y
authors.initials: Y
authors.lastname: Yi
mesh_terms: D002648:Child; D002675:Child, Preschool; D017234:Eye Evisceration; D005134:Eye Neoplasms / Q000473:pathology / Q000628:therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D008297:Male; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D011379:Prognosis; D012175:Retinoblastoma / Q000473:pathology / Q000628:therapy