A novel immunoglobulin superfamily receptor for cellular and viral MHC class I molecules.
The human cytomegalovirus UL18 gene product is a homolog of cellular major histocompatibility (MHC) class I antigens. UL18 has been proposed to protect virus-infected cells against natural killer (NK) cell cytotoxicity by engaging NK cell killer inhibitory receptors (KIR) for MHC class I. UL18 binds to a novel immunoglobulin superfamily glycoprotein, designated Leukocyte Immunoglobulin-like Receptor (LIR-1). This protein is distinct from, but related to, known KIRs and binds cellular MHC class I antigens. The cytoplasmic domain of LIR-1 contains four putative immunoreceptor tyrosine-based inhibitory motifs. Upon tyrosine phosphorylation, LIR-1 associates with the tyrosine phosphatase SHP-1. In contrast to KIRs, LIR-1 is expressed predominantly on monocytic and B lymphoid cell types, suggesting a distinct biological function.
Cosman
D
D
Immunex Corporation, Seattle, Washington 98101, USA. dcosman@immunex.com
Fanger
N
N
Borges
L
L
Kubin
M
M
Chin
W
W
Peterson
L
L
Hsu
M L
ML
D000595:Amino Acid Sequence; D000818:Animals; D015703:Antigens, CD; D001402:B-Lymphocytes / Q000378:metabolism; D019556:COS Cells; D002213:Capsid / Q000378:metabolism; D036022:Capsid Proteins; D002417:Cattle; D003587:Cytomegalovirus / Q000276:immunology / Q000378:metabolism; D015395:Histocompatibility Antigens Class I / Q000378:metabolism*; D006801:Humans; D007136:Immunoglobulins / Q000276:immunology / Q000378:metabolism*; D047908:Intracellular Signaling Peptides and Proteins; D007694:Killer Cells, Natural / Q000378:metabolism; D000075362:Leukocyte Immunoglobulin-like Receptor B1; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008969:Molecular Sequence Data; D009000:Monocytes / Q000378:metabolism; D054592:Protein Tyrosine Phosphatase, Non-Receptor Type 11; D053824:Protein Tyrosine Phosphatase, Non-Receptor Type 6; D017027:Protein Tyrosine Phosphatases / Q000378:metabolism; D011971:Receptors, Immunologic / Q000096:biosynthesis / Q000302:isolation & purification* / Q000378:metabolism; D011991:Receptors, Virus / Q000096:biosynthesis / Q000302:isolation & purification* / Q000378:metabolism; D018139:Simplexvirus / Q000378:metabolism; D014764:Viral Proteins / Q000378:metabolism*
D015703:Antigens, CD; D036022:Capsid Proteins; D015395:Histocompatibility Antigens Class I; D007136:Immunoglobulins; D047908:Intracellular Signaling Peptides and Proteins; C105299:LILRB1 protein, human; D000075362:Leukocyte Immunoglobulin-like Receptor B1; D011971:Receptors, Immunologic; D011991:Receptors, Virus; C079750:VP23 protein, Human herpesvirus 1; D014764:Viral Proteins; C516724:PTPN11 protein, human; C509249:PTPN6 protein, human; D054592:Protein Tyrosine Phosphatase, Non-Receptor Type 11; D053824:Protein Tyrosine Phosphatase, Non-Receptor Type 6; D017027:Protein Tyrosine Phosphatases; C516725:Ptpn11 protein, mouse; C509248:Ptpn6 protein, mouse