title: Overcoming Streptococcus agalactiae in vitro resistance to imidazoles.
abstract: The increased diffusion of Streptococcus agalactiae in the urinary tract and vagina has affected the strain's resistance to antimicrobial agents, so we decided to study the possibility of overcoming its resistance to imidazoles. Our data suggest that overcoming S. agalactiae resistance to imidazoles in contact and growth culture tests depends partly on the electrical conductivity of the culture medium. Although imidazole contact activity and culture activity have different targets in cell structures, we have demonstrated that imidazole resistance in S. agalactiae cells in both types of tests can be affected by the same conditions regulating membrane permeability.
authors.affiliation: Istituto di Microbiologia, Università di Roma La Sapienza, Italy.
authors.forename: N
authors.initials: N
authors.lastname: Simonetti
authors.forename: S
authors.initials: S
authors.lastname: Baffa
authors.forename: G
authors.initials: G
authors.lastname: Simonetti
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000935:Antifungal Agents / Q000494:pharmacology*; D002463:Cell Membrane Permeability; D003470:Culture Media / Q000737:chemistry; D004352:Drug Resistance, Microbial; D004553:Electric Conductivity; D005260:Female; D006801:Humans; D007093:Imidazoles / Q000494:pharmacology*; D008297:Male; D008825:Miconazole / Q000031:analogs & derivatives* / Q000494:pharmacology*; D013203:Staphylococcal Infections / Q000382:microbiology / Q000652:urine; D013292:Streptococcus agalactiae / Q000187:drug effects*; D014552:Urinary Tract Infections / Q000382:microbiology / Q000652:urine
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D003470:Culture Media; D007093:Imidazoles; C108287:miconazole-5-sulfosalicylate; D008825:Miconazole