title: Effectiveness of periodontal treatments on cyclosporine-induced gingival overgrowth in transplant patients.
abstract: OBJECTIVE
  Evaluation of the effectiveness of periodontal treatments on cyclosporine-induced gingival overgrowth.
  
  
  METHODS
  Longitudinal study between months 6 and 12 after transplant, in 80 cyclosporine-treated heart, liver and kidney transplant patients.
  
  
  METHODS
  Madrid Puerta de Hierro Hospital.
  
  
  METHODS
  The 37 patients who had developed overgrowth in the sixth month were randomly split into three study groups. The remaining 43 were split into two additional groups.
  
  
  METHODS
  The first group underwent professional cleaning; the second underwent, additionally, scaling and root planing, and the third group received no treatment. The fourth and the fifth groups received no treatment and professional cleaning, respectively.
  
  
  METHODS
  O'Leary plaque index, Lenox and Kopczyk gingival index, and average gingival overgrowth.
  
  
  RESULTS
  A significant (P = 0.008) increase in overgrowth was found in the third group that did not undergo treatment. Significantly (P = 0.002) less was found in the first and second groups. Highly significant (P = 0.001) reductions in the plaque and gingivitis indices were also found in these two groups. The fifth group showed a highly significant (P = 0.0001) decrease in the plaque and gingivitis indices.
  
  
  CONCLUSIONS
  Professional cleaning is effective in reducing both gingivitis and cyclosporine-induced gingival overgrowth; the combination with scaling and root planing reinforces its effectiveness.
authors.affiliation: Complutense University, Faculty of Dentistry, Department of Oral Medicine and Surgery, Madrid, Spain.
authors.forename: M L
authors.initials: ML
authors.lastname: Somacarrera
authors.forename: M
authors.initials: M
authors.lastname: Lucas
authors.forename: C
authors.initials: C
authors.lastname: Scully
authors.forename: C
authors.initials: C
authors.lastname: Barrios
mesh_terms: D000328:Adult; D016572:Cyclosporine / Q000009:adverse effects*; D003773:Dental Plaque / Q000473:pathology / Q000517:prevention & control; D003774:Dental Plaque Index; D003777:Dental Prophylaxis; D012534:Dental Scaling; D005069:Evaluation Studies as Topic; D005260:Female; D005500:Follow-Up Studies; D019214:Gingival Overgrowth / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D005891:Gingivitis / Q000473:pathology / Q000517:prevention & control; D016027:Heart Transplantation; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D016030:Kidney Transplantation; D016031:Liver Transplantation; D008137:Longitudinal Studies; D008297:Male; D010512:Periodontal Index; D016745:Root Planing; D016896:Treatment Outcome
chemical_list: D007166:Immunosuppressive Agents; D016572:Cyclosporine