Scleroderma, D-penicillamine treatment, and progressive renal failure associated with positive antimyeloperoxidase antineutrophil cytoplasmic antibodies.
Progressive renal failure in patients with scleroderma is a sinister development that is usually attributed to impaired renal blood flow. In some exceptional cases, the underlying pathology is a crescentic glomerulonephritis, which has been associated with positive antineutrophil cytoplasmic antibodies, and in particular antimyeloperoxidase antibodies. The prognosis in such cases has been very poor. We report such a patient whose renal function has improved and stabilized on immunosuppressive therapy.
Hillis
G S
GS
Department of Medicine, University of Aberdeen, Scotland.
Khan
I H
IH
Simpson
J G
JG
Rees
A J
AJ
D019268:Antibodies, Antineutrophil Cytoplasmic / Q000032:analysis*; D001323:Autoantibodies / Q000032:analysis*; D005260:Female; D005921:Glomerulonephritis / Q000139:chemically induced / Q000209:etiology / Q000276:immunology; D006801:Humans; D008875:Middle Aged; D010396:Penicillamine / Q000009:adverse effects / Q000627:therapeutic use*; D009195:Peroxidase / Q000276:immunology*; D051437:Renal Insufficiency / Q000209:etiology* / Q000276:immunology; D012595:Scleroderma, Systemic / Q000150:complications* / Q000188:drug therapy / Q000276:immunology
D019268:Antibodies, Antineutrophil Cytoplasmic; D001323:Autoantibodies; D009195:Peroxidase; D010396:Penicillamine