[Regional brain calcium change in rabbit cerebral ischemia].
OBJECTIVE
To study whether regional brain calcium change would be an important factor for ischemic neuranal damage and whether calcium antagonist would exert protective effects on cerebral ischemia.


METHODS
OCPC autoanalyzer method, was used to measure the regional brain calcium and observe the influence of flunarizine (FNZ) 48 hours after the rabbit middle cerebral artery occlusion (MCAO).


RESULTS
48 hours after MCAO, the calcium in the ischemic middle cerebral artery territory was 10.8 times as much as that in the pseudo-occluded controls, and FNZ could significantly decrease the ischemic brain calcium (P < 0.05) and the ischemic cerebral edema (P < 0.01).


CONCLUSIONS
Caoverload was animportant factor leading to ischemic neuronal death, and FNZ has protective effects on cerebral ischemia.
Gu
W
W
Institute of Neurology, Xiangya Hospital, Hunan Medical University, Changsha.
Yang
Q
Q
Ou
Y
Y
D000818:Animals; D001921:Brain / Q000378:metabolism*; D002545:Brain Ischemia / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism*; D002121:Calcium Channel Blockers / Q000494:pharmacology; D005444:Flunarizine / Q000494:pharmacology; D011817:Rabbits; D011897:Random Allocation
D002121:Calcium Channel Blockers; D005444:Flunarizine; D002118:Calcium