Keratoprosthesis results in animals: an update.
BACKGROUND
The report presented is an update on continuing development work on modified PHEMA core-and-shirt KPros in animals.


METHODS
Two variations (improved wet-eye, and dry-eye) of a prototype core-and-skirt Chirila KPro are described. The clinical success rate on implantation of these versions of the Chirila KPro was assessed.


RESULTS
It was found that a significant improvement in retention rate was shown in the improved model but that the dry-eye model failed early in two of the three implanted.


CONCLUSIONS
The significance of the improved strength and the reasons for disappointing results with the early dry-eye KPros are discussed. Ongoing work is briefly outlined.
Hicks
C R
CR
Lions Eye Institute, Nedlands, Australia.
Lou
X
X
Platten
S
S
Clayton
A B
AB
Vijayasekaran
S
S
Fitton
H J
HJ
Chirila
T V
TV
Crawford
G J
GJ
Constable
I J
IJ
D000818:Animals; D001672:Biocompatible Materials; D003315:Cornea / Q000473:pathology / Q000601:surgery*; D005500:Follow-Up Studies; D008689:Methacrylates; D011183:Postoperative Complications; D019736:Prostheses and Implants / Q000009:adverse effects; D011817:Rabbits; D013552:Swine
D001672:Biocompatible Materials; D008689:Methacrylates; C005044:hydroxyethyl methacrylate