The role of CD1 molecules in immune responses to infection.
Recent work on CD1 molecules has demonstrated that human CD1b and a lipoglycan from mycobacteria that CD1b presents colocalize to late endosomes. Presentation of this lipoglycan by CD1b requires antigen uptake via the mannose receptor. CD8(+) CD1-restricted T cells can decrease the load of intracellular mycobacteria by granule release. TCR-transgenic and CD1-deficient mice have provided insights into the role of CD1 in the T helper responses required for the clearance of some microorganisms.
Maher
J K
JK
Department of Microbiology, Molecular Biology Institute University of California at Los Angeles, Los Angeles, CA 90095, USA. juli@liai.org
Kronenberg
M
M
D000818:Animals; D017951:Antigen Presentation / Q000276:immunology*; D000942:Antigens, Bacterial / Q000276:immunology; D018949:Antigens, CD1 / Q000502:physiology*; D000953:Antigens, Protozoan / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D011992:Endosomes / Q000276:immunology; D006801:Humans; D007239:Infections / Q000276:immunology*; D007896:Leishmaniasis / Q000276:immunology; D008070:Lipopolysaccharides / Q000276:immunology; D051379:Mice; D008822:Mice, Transgenic; D009161:Mycobacterium / Q000276:immunology; D009164:Mycobacterium Infections / Q000276:immunology; D011948:Receptors, Antigen, T-Cell / Q000172:deficiency / Q000276:immunology
D000942:Antigens, Bacterial; D018949:Antigens, CD1; D000953:Antigens, Protozoan; D008070:Lipopolysaccharides; D011948:Receptors, Antigen, T-Cell