Granulocyte colony-stimulating factor (G-CSF) serum levels in surgical intensive care patients.
The granulocyte colony-stimulating factor (G-CSF) regulates neutrophil differentiation and function. Serum levels of G-CSF increase during acute infectious processes. The levels of G-CSF were measured in 59 surgical intensive care unit (ICU) patients. In general, G-CSF was only elevated during the first 2 days after admission to the ICU. Higher G-CSF levels were more frequently observed in patients without infectious complications and in patients who survived. Later on, G-CSF levels were below 100 pg/ml in almost all patients studied. The highest G-CSF level (20,000 pg/ml) was observed in one patient with septic shock 36 h after leukopenia. The patient recovered from septic shock and multiple organ failure and was discharged. It is proposed that surgical ICU patients with low or undetectable G-CSF serum levels may benefit from exogenous G-CSF substitution protocols.
Gross-Weege
W
W
Klinik für Allgemeine und Unfallchirurgie, Heinrich-Heine Universität Düsseldorf, Germany.
Dumon
K
K
Dahmen
A
A
Schneider
E M
EM
Röher
H D
HD
D018806:APACHE; D000368:Aged; D000704:Analysis of Variance; D016470:Bacteremia / Q000097:blood*; D003428:Cross Infection / Q000097:blood*; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000096:biosynthesis / Q000097:blood*; D006801:Humans; D007362:Intensive Care Units; D008297:Male; D008875:Middle Aged; D011863:Radioimmunoassay; D012772:Shock, Septic / Q000097:blood*; D013530:Surgical Wound Infection / Q000097:blood
D016179:Granulocyte Colony-Stimulating Factor