title: [Blood levels of protein markers of inflammation and nutrition in the meningo-encephalitis phase of human African trypanosomiasis].
abstract: Two acute phase proteins; C-reactive protein and acid alpha 1-glycoprotein and three nutritional markers; prealbumin, retinol binding protein and transferrin have been evaluated in 8 patients suffering from trypanosomiasis in meningoencephalitic state and compared to those obtained from 15 normal control subjects. Findings show a markly decrease of nutritional markers without change of sera acute phase proteins. We concluded that in meningo-encephalitic state of human african trypanosomiasis, denutrition was a major biological or clinical feature in association with lymphoid cells stimulation as revealed by beta 2-M levels.
authors.affiliation: Laboratoire de biochimie, Faculté de pharmacie, Côte d'lvoire.
authors.forename: D
authors.initials: D
authors.lastname: Monnet
authors.forename: A
authors.initials: A
authors.lastname: Lonsdorfer
authors.forename: K
authors.initials: K
authors.lastname: Pénali
authors.forename: D
authors.initials: D
authors.lastname: Valéro
authors.forename: F
authors.initials: F
authors.lastname: Doua
authors.forename: P
authors.initials: P
authors.lastname: Bogui
authors.forename: A E
authors.initials: AE
authors.lastname: Yapo
mesh_terms: D000209:Acute-Phase Proteins / Q000032:analysis*; D000293:Adolescent; D000328:Adult; D000368:Aged; D001402:B-Lymphocytes / Q000276:immunology; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis; D005260:Female; D006801:Humans; D006942:Hypergammaglobulinemia / Q000209:etiology / Q000276:immunology; D008213:Lymphocyte Activation; D008297:Male; D008590:Meningoencephalitis / Q000097:blood / Q000469:parasitology*; D008875:Middle Aged; D009748:Nutrition Disorders / Q000209:etiology; D009747:Nutritional Physiological Phenomena; D009961:Orosomucoid / Q000032:analysis; D011228:Prealbumin / Q000032:analysis; D012177:Retinol-Binding Proteins / Q000032:analysis; D013601:T-Lymphocytes / Q000276:immunology; D014168:Transferrin / Q000032:analysis; D014353:Trypanosomiasis, African / Q000097:blood* / Q000150:complications / Q000276:immunology
chemical_list: D000209:Acute-Phase Proteins; D015415:Biomarkers; D009961:Orosomucoid; D011228:Prealbumin; D012177:Retinol-Binding Proteins; D014168:Transferrin; D002097:C-Reactive Protein