Anesthetic interactions following bolus injections.
The article presents two main principles of anesthetic interactions: (1) In contrast to the interactions of inhalational anesthetics (when deviations from additivity are debatable), profound synergistic and antagonistic anesthetic interactions between different classes of intravenous drugs are possible due to the difference in the mechanism of their action, (2) A combination of intravenous anesthetics may provide different outcomes (addition, synergism, or antagonism) regarding different components of anesthesia (eg, unconsciousness or movement to noxious stimulation) because the components, even if induced by one anesthetic drug, have different underlying mechanisms.
Kissin
I
I
Department of Anaesthesia, Harvard Medical School, Boston, MA, USA.
D019162:Anesthetics, Combined / Q000493:pharmacokinetics / Q000494:pharmacology*; D018686:Anesthetics, Intravenous / Q000493:pharmacokinetics / Q000494:pharmacology*; D004347:Drug Interactions; D006801:Humans; D007275:Injections, Intravenous; D016896:Treatment Outcome
D019162:Anesthetics, Combined; D018686:Anesthetics, Intravenous