title: Activation and inactivation steps in the visual transduction pathway.
abstract: Recent genetic, biochemical and electrophysiological evidence has provided insights into the molecular identity of the substance responsible for bleaching desensitization in vision. Studies examining the molecular defects that cause delayed dark adaptation suggest that the desensitizing substance is recognized by rhodopsin kinase and/or arrestin and, therefore, is probably a complex comprising all-trans-retinal and opsin.
authors.affiliation: Department of Ophthalmology, University of Washington, Box 356485, Seattle, Washington 98195-6485, USA. palczews@u.washington.edu
authors.forename: K
authors.initials: K
authors.lastname: Palczewski
authors.forename: J C
authors.initials: JC
authors.lastname: Saari
mesh_terms: D000818:Animals; D004594:Electrophysiology; D006801:Humans; D012243:Rhodopsin / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*; D014795:Visual Pathways / Q000502:physiology*
chemical_list: D012243:Rhodopsin