HIV-associated oral pleomorphic B-cell malignant lymphoma.
A 48-year-old HIV-seropositive homosexual patient presented with an ulcerative lesion in the left side of the soft palate, extensively involving local soft tissue structures. On histologic evaluation the lesions appeared to be a large-cell high-grade B-cell pleomorphic lymphoma with anaplastic and plasmacytoid features harboring Epstein-Barr virus genome in the tumor cells. Although known to be associated with HIV infection, this is a rare subtype of a malignant lymphoma arising in a patient positive for HIV. Its meaning is yet unknown in biologic and prognostic terms.
Vázquez-Piñeiro
T
T
Department of Oral Medicine, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
Viana de Frías
L
L
Cristóbal
E
E
Cosín
J
J
Menárguez
J
J
D017809:Fatal Outcome; D004854:Herpesvirus 4, Human / Q000235:genetics; D006801:Humans; D016483:Lymphoma, AIDS-Related / Q000473:pathology* / Q000821:virology*; D017728:Lymphoma, Large-Cell, Anaplastic / Q000473:pathology* / Q000821:virology*; D008297:Male; D008875:Middle Aged; D009959:Oropharyngeal Neoplasms / Q000473:pathology* / Q000821:virology*; D012367:RNA, Viral / Q000032:analysis; D014057:Tomography, X-Ray Computed
D012367:RNA, Viral