Inhibition of azoxymethane-initiated colon tumor by bovine lactoferrin administration in F344 rats.
The influence of bovine lactoferrin (bLF) on colon carcinogenesis was investigated in male F344 rats treated with azoxymethane (AOM). Following three weekly injections of AOM, the animals received 2 or 0.2% bLF for 36 weeks. No effects indicative of toxicity were noted, but significant reduction in both the incidence and number of adenocarcinomas of the large intestine was observed with both doses. Thus, the incidences of adenocarcinomas in the groups receiving 2% and 0.2% bLF were 15% and 25%, respectively, in contrast to the 57.5% control value (P < 0.01 and P < 0.05, respectively). The results indicate that bLF might find application for chemoprevention of colon cancer.
Sekine
K
K
Chemotherapy Division, National Cancer Center Research Institute, Tokyo.
Watanabe
E
E
Nakamura
J
J
Takasuka
N
N
Kim
D J
DJ
Asamoto
M
M
Krutovskikh
V
V
Baba-Toriyama
H
H
Ota
T
T
Moore
M A
MA
Masuda
M
M
Sugimoto
H
H
Nishino
H
H
Kakizoe
T
T
Tsuda
H
H
D000230:Adenocarcinoma / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D000236:Adenoma / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control; D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D001397:Azoxymethane / Q000037:antagonists & inhibitors / Q000633:toxicity*; D002277:Carcinoma / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control; D002417:Cattle; D003110:Colonic Neoplasms / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D015994:Incidence; D007414:Intestinal Neoplasms / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D007420:Intestine, Large / Q000473:pathology; D007421:Intestine, Small / Q000473:pathology; D007781:Lactoferrin / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011916:Rats, Inbred F344
D016588:Anticarcinogenic Agents; D007781:Lactoferrin; D001397:Azoxymethane