title: Decursinol angelate: a cytotoxic and protein kinase C activating agent from the root of Angelica gigas.
abstract: A cytotoxic compound was purified from the root of Angelica gigas Nakai by normal phase HPLC. As a result of the structure analysis by mass, IR, 1H-NMR, and 13C-NMR spectrometry, the compound was identified as decursinol angelate, a structural isomer of decursin, and characterized originally from Sesei grandivittatum. Decursinol angelate showed in vitro cytotoxicity and protein kinase C activating activities like decursin.
authors.forename: K S
authors.initials: KS
authors.lastname: Ahn
authors.forename: W S
authors.initials: WS
authors.lastname: Sim
authors.forename: I K
authors.initials: IK
authors.lastname: Lee
authors.forename: Y B
authors.initials: YB
authors.lastname: Seu
authors.forename: I H
authors.initials: IH
authors.lastname: Kim
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology*; D001578:Benzopyrans / Q000737:chemistry / Q000494:pharmacology*; D002087:Butyrates / Q000737:chemistry / Q000494:pharmacology*; D004789:Enzyme Activation; D006801:Humans; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry*; D011493:Protein Kinase C / Q000378:metabolism*; D013057:Spectrum Analysis; D014407:Tumor Cells, Cultured
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D001578:Benzopyrans; D002087:Butyrates; C101278:decursin; D011493:Protein Kinase C