Endogenous retroviruses and the evolution of resistance to retroviral infection.
The current AIDS epidemic has rekindled interest in the evolution of retroviruses and the development of resistance to infection. Retroviruses and their vertebrate hosts have coexisted for millions of years, during which time a variety of host defence mechanisms has evolved. One repeated strategy is to use endogenous retroviruses to combat infection by their exogenous relatives.
Best
S
S
Wellcome Trust Centre for Human Genetics, Oxford, UK. sbest@well.ox.ac.uk
Le Tissier
P R
PR
Stoye
J P
JP
D000818:Animals; D005075:Biological Evolution; D016679:Genome, Viral; D006801:Humans; D011991:Receptors, Virus / Q000235:genetics / Q000502:physiology; D012190:Retroviridae / Q000235:genetics* / Q000276:immunology / Q000472:pathogenicity*; D012192:Retroviridae Infections / Q000235:genetics* / Q000276:immunology* / Q000821:virology; D014779:Virus Replication / Q000235:genetics / Q000276:immunology
D011991:Receptors, Virus