[Quantitative evaluation of health risk associated with occupational inhalation exposure to vinyl chloride at production plants in Poland].
Vinyl chloride is classified by the IARC in group 1-human carcinogens. In Poland occupational exposure to vinyl chloride is found among workers employed in many branches of industry, among others in the industry of vinyl chloride synthesis and polymerization as well as in the plastics, footwear, rubber, pharmaceutical and metallurgical industries. Concentrations observed range from the noon-determinable level to 90 mg/m3, at the MAC value equal to 5 mg/m3. Neoplasm of liver is a major carcinogenic effect of vinyl chloride. Hence, the health assessment focused on this critical risk. Four different linear dose-response models, developed by several authors and based on results of different epidemiological studies, were used to characterise the extent of cancer risk depending on the level of vinyl chloride concentrations. The estimated risk related to a forty-year employment under exposure equal to MAC values (5 mg/m3) fell within the range from 2.9.10(-4) to 2.6.10(-3). As the figures depict it did not exceed the acceptable level (10(-3)).
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Zakładu Epidemiologii Srodowiskowej Instytutu Medycyny Pracy, Lodzi.
D000395:Air Pollutants, Occupational / Q000009:adverse effects / Q000032:analysis*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008113:Liver Neoplasms / Q000139:chemically induced*; D008452:Maximum Allowable Concentration; D009369:Neoplasms / Q000139:chemically induced; D009784:Occupational Diseases / Q000139:chemically induced*; D011044:Poland; D018570:Risk Assessment; D014752:Vinyl Chloride / Q000008:administration & dosage / Q000009:adverse effects / Q000032:analysis*
D000395:Air Pollutants, Occupational; D014752:Vinyl Chloride