title: Ophthalmic findings in a case of hemophagocytic syndrome.
abstract: OBJECTIVE
  To report a case of hemophagocytic syndrome, which is characterized by hemophagocytosis of histiocytes; optic nerve involvement, and unusual retinal white patches.
  
  
  METHODS
  Case report. A 10-year-old boy had repeated relapses of hemophagocytic syndrome. He complained of swelling of the right upper eyelid and bilateral visual disturbance.
  
  
  RESULTS
  Ophthalmoscopic examination disclosed bilateral optic disk edema, retinal hemorrhages, and multiple perivenous white patches in the retina. Magnetic resonance imaging demonstrated enlargement of both optic nerves. After chemotherapy and bone marrow transplantation, his visual acuity improved in both eyes, and retinal patches changed to inactive-appearing scars.
  
  
  CONCLUSIONS
  Hemophagocytic syndrome may manifest with ophthalmic findings such as optic nerve involvement, retinal hemorrhages, and multiple white perivenous retinal patches.
authors.affiliation: Department of Ophthalmology, Osaka Medical Center and Research Institute for Maternal and Child Health, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Kawamura
authors.forename: Y
authors.initials: Y
authors.lastname: Hatsukawa
authors.forename: A
authors.initials: A
authors.lastname: Furukawa
authors.forename: M
authors.initials: M
authors.lastname: Inoue
authors.forename: K
authors.initials: K
authors.lastname: Kawa
mesh_terms: D002648:Child; D005128:Eye Diseases / Q000150:complications* / Q000175:diagnosis; D005334:Fever / Q000150:complications* / Q000175:diagnosis; D005654:Fundus Oculi; D006529:Hepatomegaly / Q000150:complications* / Q000175:diagnosis; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009900:Optic Nerve / Q000473:pathology; D009915:Orbit / Q000473:pathology; D010198:Pancytopenia / Q000150:complications* / Q000175:diagnosis; D013163:Splenomegaly / Q000150:complications* / Q000175:diagnosis; D013577:Syndrome