title: Efficacy of methotrexate and misoprostol for early abortion.
abstract: BACKGROUND
  Medical termination of pregnancy (medical abortion) as an alternative to surgical abortion has many advantages since it does not require anesthetics and there is no risk of cervical laceration or uterine perforation. In the present study, we evaluated the efficacy of methotrexate and intravaginally administered misoprostol for early abortion.
  
  
  METHODS
  The study population consisted of 32 women seeking abortion of a normal intrauterine pregnancy of 8 weeks or less documented by ultrasound. The dose of methotrexate was 50 mg/m2 intramuscularly and the dose of misoprostol was 800 micrograms intravaginally. The final outcome of treatment was evaluated on day 14 or 16, and an abortion was considered successful if pregnancy was terminated without a surgical procedure.
  
  
  RESULTS
  Abortion occurred in only 23 (71.8%) of 32 women. There were 9 failures (28.1%); 3 were ongoing pregnancies (9.3%) and 6 were incomplete abortions (18.7%) requiring suction curettage. After the exclusion of treatment failures, the mean duration of vaginal bleeding was 16.3 +/- 2 days. No serious side effects occurred as a result of methotrexate and misoprostol treatment.
  
  
  CONCLUSIONS
  The use of methotrexate and intravaginal misoprostol for the termination of pregnancy requires larger studies to determine the safety and efficacy of this medical abortion, a comparison with RU 486 in prospective controlled randomized trials is necessary.
authors.affiliation: Department of Obstetrics and Gynecology, University of Kocaeli School of Medicine, Izmit, Turkey.
authors.forename: S
authors.initials: S
authors.lastname: Ozeren
authors.forename: A
authors.initials: A
authors.lastname: Corakçi
authors.forename: I
authors.initials: I
authors.lastname: Yücesoy
authors.forename: R
authors.initials: R
authors.lastname: Mercan
authors.forename: A
authors.initials: A
authors.lastname: Arslan
authors.forename: G
authors.initials: G
authors.lastname: Erhan
mesh_terms: D000020:Abortifacient Agents, Nonsteroidal / Q000008:administration & dosage / Q000494:pharmacology*; D000028:Abortion, Induced / Q000379:methods*; D000282:Administration, Intravaginal; D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007273:Injections, Intramuscular; D008727:Methotrexate / Q000008:administration & dosage / Q000494:pharmacology*; D016595:Misoprostol / Q000008:administration & dosage / Q000494:pharmacology*; D011247:Pregnancy; D011446:Prospective Studies
chemical_list: D000020:Abortifacient Agents, Nonsteroidal; D016595:Misoprostol; D008727:Methotrexate