title: An HTLV-I carrier with Graves' disease followed by uveitis: isolation of HTLV-I from thyroid tissue.
abstract: We report a long-term (14-year) follow-up of a human T-lymphotropic virus type I (HTLV-I)-infected male who was successively afflicted with Graves' disease followed by uveitis. HTLV-I proviral DNA was detected by polymerase chain reaction in the thyroid tissue and HTLV-I was isolated from thyroid tissue by coculture with peripheral blood lymphocytes from an HTLV-I-uninfected healthy female. This case study supports a close relationship between Graves' disease and uveitis in an HTLV-I carrier.
authors.affiliation: Department of Medicine, Kochi Medical School, Japan.
authors.forename: I
authors.initials: I
authors.lastname: Kubonishi
authors.forename: T
authors.initials: T
authors.lastname: Kubota
authors.forename: T
authors.initials: T
authors.lastname: Sawada
authors.forename: Y
authors.initials: Y
authors.lastname: Tanaka
authors.forename: H
authors.initials: H
authors.lastname: Machida
authors.forename: O
authors.initials: O
authors.lastname: Yoshida
authors.forename: A
authors.initials: A
authors.lastname: Fukushima
authors.forename: H
authors.initials: H
authors.lastname: Ueno
authors.forename: Y
authors.initials: Y
authors.lastname: Ohtsuki
authors.forename: I
authors.initials: I
authors.lastname: Miyoshi
mesh_terms: D000328:Adult; D001327:Autoimmune Diseases / Q000150:complications* / Q000235:genetics / Q000821:virology; D002353:Carrier State; D004279:DNA, Viral / Q000302:isolation & purification; D005192:Family Health; D005260:Female; D005500:Follow-Up Studies; D006111:Graves Disease / Q000150:complications* / Q000235:genetics / Q000821:virology; D015490:HTLV-I Infections / Q000150:complications*; D015368:Human T-lymphotropic virus 1 / Q000302:isolation & purification* / Q000472:pathogenicity; D006801:Humans; D008297:Male; D010375:Pedigree; D016133:Polymerase Chain Reaction; D011533:Proviruses / Q000302:isolation & purification; D013961:Thyroid Gland / Q000821:virology*; D014605:Uveitis / Q000209:etiology* / Q000601:surgery / Q000821:virology
chemical_list: D004279:DNA, Viral