New concepts in the treatment of breast cancer using high-dose chemotherapy.
High-dose chemotherapy is now frequently used for the treatment of primary and metastatic breast cancer. Two recent randomized trials have demonstrated that this treatment approach can result in extended disease-free and overall survival for patients with metastatic disease. However, treatment results have demonstrated that long term remissions from these treatments raise complex questions about traditional models of chemotherapy principles. A detailed analysis of the principles underlying high-dose therapy is presented in the context of principles of dose-response, the inverse rule and the total tumor cell kill hypotheses.
Peters
W P
WP
Karmanos Cancer Institute, Wayne State University, Detroit, MI 48201, USA.
Dansey
R
R
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D016032:Randomized Controlled Trials as Topic; D016019:Survival Analysis; D016896:Treatment Outcome