title: [Nail polish allergy. An important differential diagnosis in contact dermatitis].
abstract: METHODS
  Case 1. A 34-year-old woman presented with a recurrent, itching and erythematous plaque on her right cheek. Case 2. A 27-year-old woman reported itching erythema on her fingertips from time to time recently. Inspection revealed dyshidrosiform blisters. Both patients had been using nail varnish and varnish remover. Case 3. A 49-year-old woman had, for about 5 years, repeatedly experienced itching erythema at the perionychium of several fingers on which she had placed artificial nails. Marked oedema and erythema was noted.
  
  
  METHODS
  Extensive epicutaneous tests were performed on these patients. They showed sensitisation against important allergens in nail varnish (toluolsulphonamide-formaldehyde resin), nail varnish remover (benzophenone-2) and artificial nails (ethylacrylate), respectively. The three patients also showed type IV sensitisation against other substances.
  
  
  METHODS
  Epicutaneous tests documented type IV allergies to important constituents of nail varnish, nail varnish remover and artificial nails. Symptoms and skin changes disappeared when these three items were no longer used.
  
  
  CONCLUSIONS
  Allergies against nail varnish and its remover and against artificial nails should be included in the differential diagnosis of skin allergies, even when patients have additional type IV sensitizations against common allergens. As the causative allergen can be easily avoided, knowledge of the particular problems associated with these allergies is of a great practical significance.
authors.affiliation: Zentrum der Dermatologie und Venerologie, Klinikum der Johann-Wolfgang-Goethe-Universität Frankfurt/Main.
authors.forename: W H
authors.initials: WH
authors.lastname: Boehncke
authors.forename: M
authors.initials: M
authors.lastname: Schmitt
authors.forename: T M
authors.initials: TM
authors.lastname: Zollner
authors.forename: O
authors.initials: O
authors.lastname: Hensel
mesh_terms: D000328:Adult; D002610:Cheek; D003358:Cosmetics / Q000009:adverse effects*; D017449:Dermatitis, Allergic Contact / Q000175:diagnosis* / Q000209:etiology; D003937:Diagnosis, Differential; D005148:Facial Dermatoses / Q000139:chemically induced / Q000175:diagnosis*; D005260:Female; D005385:Fingers; D006229:Hand Dermatoses / Q000139:chemically induced / Q000175:diagnosis*; D006801:Humans; D008875:Middle Aged; D009260:Nail Diseases / Q000139:chemically induced / Q000175:diagnosis*; D009262:Nails; D012882:Skin Tests
chemical_list: D003358:Cosmetics