UV curable bioadhesives: copolymers of N-vinyl pyrrolidone.
A series of UV curable bioadhesives was prepared from copolymers of N-vinyl pyrrolidone with four different comonomers: 2-acrylamido methyl 1-propane sulfonic acid, vinyl succinimide, glycidyl acrylate, and 2-isocyanatoethyl methacrylate. The developed bioadhesives demonstrated a fast UV-induced setting with a set time of about 3 min. Bond strength between the bioadhesive and porcine intestine specimen was determined by the peel test. These bioadhesives can provide improved adhesion values up to 4.6 N/m of 180 degrees peel strength compared to five different commercial bioadhesives (values ranging from 0.52 to 3.04 N/m). In addition, the fully hydrated UV curable bioadhesives have shown a high water uptake ranging from 25 to 350 wt% and equilibrium water content ranging from 20 to 100 wt%. Because N-vinyl pyrrolidone is a monomer all these copolymers are expected to retain good biocompatibility. Obtained promising results of peel strength and water uptake clearly suggest that the developed bioadhesives have a strong potential for many medical applications such as single-layered hydrogel wound dressings and tissue adhesives.
Kao
F J
FJ
Department of Chemistry, University of Massachusetts Lowell 01854, USA.
Manivannan
G
G
Sawan
S P
SP
D000269:Adhesives / Q000737:chemistry*; D000818:Animals; D001672:Biocompatible Materials / Q000528:radiation effects*; D011108:Polymers; D011760:Pyrrolidinones / Q000737:chemistry* / Q000528:radiation effects; D013552:Swine; D014466:Ultraviolet Rays; D014867:Water / Q000032:analysis
D000269:Adhesives; D001672:Biocompatible Materials; D011108:Polymers; D011760:Pyrrolidinones; D014867:Water; C042670:N-vinyl-2-pyrrolidinone