Molecular mechanisms of hormone controlled gene expression in the breast.
In a meritorious effort H. de Rothschild compiled in 1899 all publications on mammary gland development and milk--a grand total of 8375 [1]. In the preface to this publication Duclaux states: 'Such a discrepancy between the tremendous efforts and the paltriness of the results--hundreds of scientists and thousands of research years, just to create 200 or 300 pages of truth'. The number of papers added since then must be enormous. Rather than reviewing a vast literature, I will take the liberty and focus on research which, in my opinion, shaped our understanding of hormone controlled gene expression in the developing breast.
Hennighausen
L
L
Laboratory of Biochemistry and Metabolism, NIDDK, National Institutes of Health, Bethesda, MD 20892-1812, USA.
D000818:Animals; D001940:Breast / Q000254:growth & development / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D005260:Female; D005786:Gene Expression Regulation; D018507:Gene Expression Regulation, Developmental; D006728:Hormones / Q000235:genetics* / Q000378:metabolism*; D006801:Humans; D008321:Mammary Glands, Animal / Q000254:growth & development / Q000378:metabolism*; D051379:Mice; D008822:Mice, Transgenic; D008894:Milk Proteins / Q000235:genetics / Q000378:metabolism; D011388:Prolactin / Q000235:genetics / Q000378:metabolism; D011817:Rabbits; D050799:STAT5 Transcription Factor; D015534:Trans-Activators / Q000235:genetics / Q000378:metabolism
D004268:DNA-Binding Proteins; D006728:Hormones; D008894:Milk Proteins; D050799:STAT5 Transcription Factor; D015534:Trans-Activators; C024471:whey acidic proteins; D011388:Prolactin