title: Sustained improvement in photodamaged skin with reduced tretinoin emollient cream treatment regimen: effect of once-weekly and three-times-weekly applications.
abstract: BACKGROUND
  Previous studies have documented reversal of long-term photodamage with once-daily applications of topical tretinoin.
  
  
  OBJECTIVE
  Our purpose was to assess the effectiveness of tretinoin emollient cream in maintaining improvement in photodamage with a reduced frequency of applications.
  
  
  METHODS
  A total of 126 subjects who completed 48 weeks of once-daily treatment with tretinoin emollient cream 0.05% were enrolled for an additional 24 weeks of tretinoin once weekly, three times weekly, or no therapy.
  
  
  RESULTS
  The clinical improvement observed during 48 weeks of once-daily treatment was sustained with three-times weekly applications and to a lesser extent with once-weekly dosing, whereas effects tended to regress in subjects off therapy. The overall incidence of adverse events in the skin and subcutaneous tissues appeared to vary with dose frequency.
  
  
  CONCLUSIONS
  After 48 weeks of once-daily treatment, the continued use of tretinoin emollient cream 0.05% at a dose of three times per week maintains and, in some cases, may further enhance improvement in photodamage. Discontinuation of therapy results in some reversal of beneficial effects.
authors.affiliation: Dermatopharmacology Study Center, Duke University Medical Center, Durham, NC 27710, USA.
authors.forename: E A
authors.initials: EA
authors.lastname: Olsen
authors.forename: H I
authors.initials: HI
authors.lastname: Katz
authors.forename: N
authors.initials: N
authors.lastname: Levine
authors.forename: T P
authors.initials: TP
authors.lastname: Nigra
authors.forename: P E
authors.initials: PE
authors.lastname: Pochi
authors.forename: R C
authors.initials: RC
authors.lastname: Savin
authors.forename: J
authors.initials: J
authors.lastname: Shupack
authors.forename: G D
authors.initials: GD
authors.lastname: Weinstein
authors.forename: L
authors.initials: L
authors.lastname: Lufrano
authors.forename: H C
authors.initials: HC
authors.lastname: Jou
mesh_terms: D000328:Adult; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007641:Keratolytic Agents / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D015595:Skin Aging / Q000187:drug effects* / Q000528:radiation effects*; D014212:Tretinoin / Q000008:administration & dosage*; D014466:Ultraviolet Rays / Q000009:adverse effects*
chemical_list: D007641:Keratolytic Agents; D014212:Tretinoin