Excretion of cannabinoids in urine after ingestion of cannabis seed oil.
Gas chromatographic-mass spectrometric (GC-MS) quantitation of 25 cannabis sed oils determined delta 9-tetrahydrocannabinol (THC) concentrations from 3 to 1500 micrograms/g oil. In a pilot study, the morning urine of six volunteers who had ingested 11 or 22 g of the oil, which contained the highest THC content (1500 micrograms/g), was collected for six days. The urine samples were screened by immunoassay, and the content of 11-nor-9-carboxy-delta 9-THC (THCCOOH) was determined by GC-MS. Urine samples were found cannabis positive for up to six days with THCCOOH-equivalent concentrations up to 243 ng/mL. by the Abuscreen OnLine immunoassay and THCCOOH contents from 5 to 431 ng/mL by the GC-MS method. All subjects reported THC-specific psychotropic effects.
Lehmann
T
T
Institute of Pharmacy, University of Bern, Switzerland.
Sager
F
F
Brenneisen
R
R
D002188:Cannabis; D013759:Dronabinol / Q000031:analogs & derivatives* / Q000032:analysis / Q000494:pharmacology / Q000652:urine*; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods; D006801:Humans; D007118:Immunoassay; D010938:Plant Oils / Q000008:administration & dosage* / Q000032:analysis / Q000494:pharmacology; D011619:Psychotropic Drugs / Q000494:pharmacology; D012639:Seeds
D010938:Plant Oils; D011619:Psychotropic Drugs; C016780:11-nor-delta(9)-tetrahydrocannabinol-9-carboxylic acid; D013759:Dronabinol