[Intraoperative serum parathyroid hormone measurement in the surgical treatment of hyperparathyroidism].
BACKGROUND
PTH(1-84) short half life permits us to monitor parathyroidectomy efficacy, confirming complete resection after unilateral surgical approach in some cases of primary hyperparathyroidism. Nevertheless, this utility has been tested in controlled clinical trials and there is no agreement regarding the extraction of samples, their processing and interpretation of results.


METHODS
In 18 consecutive patients operated on for primary or secondary hyperparathyroidism, serum PTH(1-84) concentrations were assessed at different times before, during and after partial (in 11 patients with multiglandular illness) and total resections.


RESULTS
Initial PTH(1-84) concentrations very largely in different pre-resection samples, and these variations significantly affect post-resection percentage reduction. Plasmatic clearance of PTH(1-84) after incomplete resection follows a decreasing exponential curve towards new equilibrium concentrations. The difference is significant comparing with concentrations following complete resection only 5 minutes after, but the 95% intervals with a confidence level of 90% of confidence are exclusive only for determinations after 120 minutes.


CONCLUSIONS
The decrement of serum PTH(1-84) concentrations to 20% of the preresection levels 120 minutes after an adenomectomy confirms the complete removal of all pathologic parathyroid tissue. A less sharp decrement must be investigated and may justify an early surgical revision.
Martín
M
M
Servicio de Bioquímica, Hospital Universitario 12 de Octubre, Universidad Complutense, Madrid.
de la Cruz Vigo
F
F
Martínez
J I
JI
Larrodera
M L
ML
Ortega
G
G
D015415:Biomarkers / Q000097:blood; D006801:Humans; D006961:Hyperparathyroidism / Q000097:blood / Q000601:surgery*; D007432:Intraoperative Period; D010281:Parathyroid Hormone / Q000097:blood*; D016105:Parathyroidectomy; D012044:Regression Analysis; D012680:Sensitivity and Specificity; D013997:Time Factors
D015415:Biomarkers; D010281:Parathyroid Hormone