High bone mass as a marker for breast cancer risk.
Postmenopausal women in the highest quartile for metacarpal bone mass were found to have an increased risk of developing breast cancer, after adjusting for age and other variables known to influence breast cancer risk. Although the mechanisms responsible for this relationship have not been identified, postmenopausal bone mass may serve as an indicator of cumulative estrogen exposure.
O'Brien
K
K
Center for Human Nutrition, Johns Hopkins University School of Hygiene and Public Health, Baltimore, MD 21205, USA.
Caballero
B
B
D015519:Bone Density; D001943:Breast Neoplasms / Q000209:etiology*; D004967:Estrogens / Q000008:administration & dosage; D005260:Female; D006801:Humans; D017698:Postmenopause; D012307:Risk Factors
D004967:Estrogens