title: Cholecystectomy-induced gastroesophageal reflux: is it reduced by the laparoscopic approach?
abstract: OBJECTIVE
  The incidence of gastroesophageal reflux and esophagitis increases significantly following cholecystectomy. Laparoscopic technique minimizes the metabolic and mechanical disturbances of cholecystectomy, but there has been no study of its effects on gastroesophageal reflux. The aim of this study was to examine the effect of laparoscopic cholecystectomy on the indices of gastroesophageal reflux.
  
  
  METHODS
  A prospective study was carried out on patients scheduled for cholecystectomy. Informed consent was obtained. Preoperative 24-h pH studies and manometry were performed. Studies were repeated 3 months after surgery. Pathological acid reflux was defined in terms of the DeMeester acid score.
  
  
  RESULTS
  Pre- and postoperative studies were carried out on 28 patients who had open cholecystectomy and on 22 patients who had laparoscopic cholecystectomy. The mean (SEM) DeMeester acid score increased from 14.8 (2.4) to 34.0 (6.7) following open cholecystectomy (p = 0.006) and from 13.9 (2.5) to 28.9 (4.3) following laparoscopic cholecystectomy (p = 0.002). Decrease in mean lower esophageal sphincter pressure in both groups was not significant.
  
  
  CONCLUSIONS
  A significant increase in the incidence of gastroesophageal reflux occurred within 3 months after surgery in both study groups. Despite the less invasive nature of laparoscopic cholecystectomy, the type of surgery did not influence the degree of esophageal dysfunction.
authors.affiliation: Department of Surgery, St. James's Hospital, Dublin, Ireland.
authors.forename: J F
authors.initials: JF
authors.lastname: Rothwell
authors.forename: P
authors.initials: P
authors.lastname: Lawlor
authors.forename: P J
authors.initials: PJ
authors.lastname: Byrne
authors.forename: T N
authors.initials: TN
authors.lastname: Walsh
authors.forename: T P
authors.initials: TP
authors.lastname: Hennessy
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002763:Cholecystectomy / Q000009:adverse effects*; D017081:Cholecystectomy, Laparoscopic / Q000009:adverse effects*; D004941:Esophagitis / Q000209:etiology; D004947:Esophagus / Q000378:metabolism / Q000503:physiopathology; D005260:Female; D005764:Gastroesophageal Reflux / Q000209:etiology* / Q000503:physiopathology; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008875:Middle Aged; D011312:Pressure; D011446:Prospective Studies