title: Varicocele in prepubertal boys. Evaluation of clinical Doppler and hormonal findings.
abstract: Hormonal, clinical and scrotal Doppler findings were assessed in 16 prepubertal patients having unilateral varicocele. As already described in pubertal patients, Doppler studies made it possible to detect patterns of prolonged, intermittent or permanent reflux. An LH-RH test and an hCG test measuring LH, FSH and testosterone (T) were performed in all cases. Patients with varicocele showed (median and range): LH B (mlU/ml): 0.40 (0.40-2.1); LH Mx.: 3.7 (1.1-15); FSH B (mlU/ml): 1.95 (0.40-4.5); FSH Mx.: 4.9 (3.1-10); T B (ng/ml): 0.2 (0.1-1.5); T Post.: 2.25 (0.82-11.5). The control group showed: LH B (mlU/ml): 0.40 (0.4-0.85); LH Mx.: 2.15 (0.63-12) FSH B (mlU/ml): 1.45 (0.4-3); FSH Mx.: 4.25 (2.6-5.9); T B (ng/ml): 0.1 (0.1-0.3); T Post.: 3.26 (1.0-5.6). No significant differences were found between the hormonal results of the different groups classified according to the scrotal findings. Basal LH and FSH in grade 3 varicoceles were found to be significantly higher (p < 0.05) than those of the control group. Basal T, as well as the maximal response of both gonadotropins to LH-RH, and T response to hCG showed no significant differences with reference to the control group. Our findings provide indirect support to the notion that the gonadal damage would become detectable from puberty onwards.
authors.affiliation: Unidad de Endocrinologia, Hospital Municipal T. Alvarez, Buenos Aires, Argentina.
authors.forename: H L
authors.initials: HL
authors.lastname: Fideleff
authors.forename: H
authors.initials: H
authors.lastname: Boquete
authors.forename: G
authors.initials: G
authors.lastname: Ruibal
authors.forename: M
authors.initials: M
authors.lastname: Suärez
authors.forename: P
authors.initials: P
authors.lastname: Sobrado
authors.forename: F
authors.initials: F
authors.lastname: Zanchetti
authors.forename: M
authors.initials: M
authors.lastname: Perco
authors.forename: M
authors.initials: M
authors.lastname: Holland
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D006063:Chorionic Gonadotropin / Q000097:blood; D005640:Follicle Stimulating Hormone / Q000097:blood*; D007987:Gonadotropin-Releasing Hormone / Q000097:blood; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood*; D008297:Male; D012611:Scrotum / Q000000981:diagnostic imaging; D013739:Testosterone / Q000097:blood*; D018608:Ultrasonography, Doppler; D014646:Varicocele / Q000097:blood / Q000000981:diagnostic imaging* / Q000503:physiopathology*
chemical_list: D006063:Chorionic Gonadotropin; D007987:Gonadotropin-Releasing Hormone; D013739:Testosterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone