title: Infectious particles derived from Semliki Forest virus vectors encoding murine leukemia virus envelopes.
abstract: Semliki Forest virus vectors encoding murine leukemia virus (MLV) envelope protein with a truncated cytoplasmic tail generate submicrometer, cell-associated, membranous particles that transmit replication-competent vector RNA specifically to cells bearing the MLV receptor. Such "minimal" viruses could have applications as retroviral vaccines or in the study of virus evolution.
authors.affiliation: Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.
authors.forename: I
authors.initials: I
authors.lastname: Lebedeva
authors.forename: K
authors.initials: K
authors.lastname: Fujita
authors.forename: A
authors.initials: A
authors.lastname: Nihrane
authors.forename: J
authors.initials: J
authors.lastname: Silver
mesh_terms: D016475:3T3 Cells; D000818:Animals; D016466:CHO Cells; D002213:Capsid; D002352:Carrier Proteins / Q000378:metabolism; D002460:Cell Line; D006224:Cricetinae; D015870:Gene Expression; D015686:Gene Products, env / Q000235:genetics / Q000378:metabolism; D005822:Genetic Vectors; D015726:Giant Cells; D008562:Membrane Glycoproteins; D008565:Membrane Proteins / Q000378:metabolism; D051379:Mice; D008979:Moloney murine leukemia virus / Q000235:genetics* / Q000378:metabolism; D011498:Protein Precursors / Q000235:genetics / Q000378:metabolism; D012367:RNA, Viral / Q000378:metabolism; D011991:Receptors, Virus; D015682:Retroviridae Proteins, Oncogenic / Q000235:genetics / Q000378:metabolism; D012672:Semliki forest virus / Q000235:genetics* / Q000472:pathogenicity; D014759:Viral Envelope Proteins / Q000235:genetics / Q000378:metabolism; D014771:Virion / Q000378:metabolism / Q000502:physiology; D019065:Virus Assembly
chemical_list: D002352:Carrier Proteins; D015686:Gene Products, env; D008562:Membrane Glycoproteins; D008565:Membrane Proteins; D011498:Protein Precursors; D012367:RNA, Viral; D011991:Receptors, Virus; D015682:Retroviridae Proteins, Oncogenic; D014759:Viral Envelope Proteins; C070506:ecotropic murine leukemia virus receptor; C078678:p15E protein, Murine leukemia virus