Desensitization of Fos protein induction in rat striatum and nucleus accumbens following repeated administration of delta9-tetrahydrocannabinol.
The purpose of the present study was to clarify the effect of repeated administration of delta9-tetrahydrocannabinol (THC) on Fos protein induction in the rat brain. Pretreatment of rats for 3 days with THC (10 mg/kg, i.p.) attenuated the effect of THC (10 mg/kg) to induce the expression of Fos protein in rat striatum and nucleus accumbens. This desensitization of Fos protein induction might explain the rapid development of behavioral tolerance to repeated administration of THC.
Miyamoto
A
A
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.
Yamamoto
T
T
Ohno
M
M
Watanabe
S
S
D000818:Animals; D003342:Corpus Striatum / Q000187:drug effects* / Q000378:metabolism; D013759:Dronabinol / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D009714:Nucleus Accumbens / Q000187:drug effects* / Q000378:metabolism; D016760:Proto-Oncogene Proteins c-fos / Q000096:biosynthesis*; D051381:Rats; D017208:Rats, Wistar
D016760:Proto-Oncogene Proteins c-fos; D013759:Dronabinol