Neuronal ceroid-lipofuscinosis in a domestic cat: clinical, morphological and immunohistochemical findings.
A 9-month-old domestic shorthair cat was humanely killed because of uncoordinated gait, myoclonus, seizures and reduced vision. Histological, immunohistochemical and ultrastructural examination revealed a neuronal storage disease consistent with neuronal ceroid-lipofuscinosis (NCL). Neurons contained Sudan black- and luxol fast blue-positive material which was autofluorescent. Immunohistochemically, the storage material was found to contain subunit c of mitochondrial ATP synthase, a protein recently recognized as the main component of the storage material in NCL. Ultrastructurally, the material consisted of curvilinear and fingerprint bodies, which are indicative of NCL.
Weissenböck
H
H
Institute of Pathology and Forensic Veterinary Medicine, University of Veterinary Medicine, Vienna, Austria.
Rössel
C
C
D000818:Animals; D015415:Biomarkers; D001921:Brain / Q000473:pathology* / Q000648:ultrastructure*; D002371:Cat Diseases / Q000473:pathology*; D002415:Cats; D002540:Cerebral Cortex / Q000473:pathology / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D008856:Microscopy, Fluorescence; D009472:Neuronal Ceroid-Lipofuscinoses / Q000473:pathology / Q000662:veterinary*; D009474:Neurons / Q000473:pathology
D015415:Biomarkers