title: Toxic properties of Beauveria pigments on erythrocyte membranes.
abstract: The Beauveria pigments, tenellin, bassianin and oosporein, all inhibited total erythrocyte membrane ATPase activity in a dose-dependent manner by as much as 50% at 200 micrograms/ml. These pigments inhibited Ca(2+)-ATPases to a greater extent than Na+/K(+)-ATPase activity. The ATPase inhibitory activity for these pigments was not specific but was probably a consequence of membrane disruption, since pigments all caused alterations in erythrocyte morphology and promoted varying degrees of cell lysis.
authors.affiliation: Department of Applied Microbiology and Food Science, University of Saskatchewan, Saskatoon, Canada.
authors.forename: L B
authors.initials: LB
authors.lastname: Jeffs
authors.forename: G G
authors.initials: GG
authors.lastname: Khachatourians
mesh_terms: D000818:Animals; D016227:Benzoquinones / Q000633:toxicity; D001693:Biological Transport, Active; D000252:Calcium-Transporting ATPases / Q000037:antagonists & inhibitors / Q000097:blood; D004791:Enzyme Inhibitors / Q000633:toxicity*; D004910:Erythrocyte Membrane / Q000187:drug effects*; D006736:Horses; D003904:Mitosporic Fungi / Q000378:metabolism*; D008954:Models, Biological; D015394:Molecular Structure; D009183:Mycotoxins / Q000633:toxicity*; D010860:Pigments, Biological / Q000633:toxicity*; D011728:Pyridones / Q000633:toxicity; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors / Q000097:blood
chemical_list: D016227:Benzoquinones; D004791:Enzyme Inhibitors; D009183:Mycotoxins; D010860:Pigments, Biological; D011728:Pyridones; C108585:bassianin; C015528:tenellin; C008706:oosporein; D000252:Calcium-Transporting ATPases; D000254:Sodium-Potassium-Exchanging ATPase