title: Compliance with malaria chemoprophylaxis and preventative measures against mosquito bites among Dutch travellers.
abstract: Self-reported compliance with a malaria chemoprophylaxis regimen of proguanil (PG) plus chloroquine (CQ) was assessed in a cohort of 547 Dutch travellers who visited a single travel clinic when travelling to various areas endemic for falciparum malaria. 503 (92%) had taken PG/CQ prophylaxis, but only 326 (60%) reported regular and uninterrupted use throughout the journey and 4 weeks afterwards. Compliance differed by travel destination and was 45% in South America, 52% in West Africa, 53% in South-east Asia, 60% in the Indian Subcontinent and 78% in East Africa. Parasitologically confirmed falciparum malaria occurred in 5 travellers (0.9%), including 3 of 24 non-compliant travellers to West Africa (12.5%). Apart from destination, independent risk factors for non-compliance were young age, extensive travel experience and adventurous travel. Compliance with protection against mosquito bites was 80% for wearing long-sleeved shirts and long-legged trousers after sunset, 73% for use of repellents, 56% for sleeping under bed nets and 37% for keeping the sleeping quarters free of mosquitoes. Although 440 travellers (80%) reported to have taken two or more of these measures at least once, only 88 (16%) had done so on a daily basis. Daily use of bed nets was reported more frequently among subjects who were non-compliant with chemoprophylaxis. Compliance regarding malaria chemoprophylaxis should be improved, particularly in high-risk areas such as Sub-saharan Africa, with extra attention to young, adventurous travellers. More emphasis should be placed on prevention of Anopheles bites.
authors.affiliation: Division of Infectious Diseases, Tropical Medicine and AIDS, University of Amsterdam, The Netherlands.
authors.forename: F G
authors.initials: FG
authors.lastname: Cobelens
authors.forename: A
authors.initials: A
authors.lastname: Leentvaar-Kuijpers
mesh_terms: D000328:Adult; D000368:Aged; D000818:Animals; D000852:Anopheles; D000962:Antimalarials / Q000627:therapeutic use*; D015331:Cohort Studies; D004197:Disease Reservoirs; D005260:Female; D006801:Humans; D007299:Insect Bites and Stings / Q000517:prevention & control*; D016778:Malaria, Falciparum / Q000188:drug therapy / Q000517:prevention & control*; D008297:Male; D008875:Middle Aged; D009426:Netherlands; D010349:Patient Compliance; D011446:Prospective Studies; D012189:Retrospective Studies; D012307:Risk Factors; D014195:Travel
chemical_list: D000962:Antimalarials