title: [Gene expression of bFGF and intimal hyperplasia of autologous vein grafts in rats].
abstract: OBJECTIVE
  To establish a model of autologous vein graft through translating jugular vein to aortic artery in 80 Wistar rats, and detect gene expression of basic fibroblast growth factor (bFGF).
  
  
  METHODS
  In situ hybridization and reverse transcription polymerase chain reaction (RT-PCR) were used.
  
  
  RESULTS
  The expression of bFGF mRNA was more decreased than that of normal artery and vein after transplantation, up to 1 week, the level of bFGF gene expression decreased to the lowest (P < 0.05). Two weeks after transplantation, bFGF transcripts recovered.
  
  
  CONCLUSIONS
  bFGF released from dead and damaged cells of autologous vein graft not only is an important factor that promotes SMC proliferation, but also is a potent stimulator of endothelial regrowth.
authors.affiliation: Department of Vascular Surgery, Renji Hospital, Shanghai.
authors.forename: H
authors.initials: H
authors.lastname: Qian
authors.forename: B
authors.initials: B
authors.lastname: Zhang
authors.forename: H
authors.initials: H
authors.lastname: Zhao
mesh_terms: D000818:Animals; D001011:Aorta / Q000601:surgery*; D002455:Cell Division; D005260:Female; D016222:Fibroblast Growth Factor 2 / Q000235:genetics*; D015870:Gene Expression; D007601:Jugular Veins / Q000473:pathology / Q000637:transplantation*; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000473:pathology*; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D014182:Transplantation, Autologous
chemical_list: D012333:RNA, Messenger; D016222:Fibroblast Growth Factor 2