Gingival squamous cell carcinoma in a patient with chronic graft-versus-host disease.
This article describes a gingival squamous cell carcinoma that developed in a 21-year-old woman who received a bone marrow transplant at the age of 16 from her human leukocyte antigen-identical sister as treatment for severe aplastic anemia. Thirty days after transplantation, she presented with cutaneous erythema as a result of acute graft-versus-host disease, and this subsequently evolved into chronic graft-versus-host disease. A lichenoid white plaque of the gingiva developed shortly thereafter, and it began to increase in size rapidly 4 years posttransplantation. Biopsy indicated squamous cell carcinoma arising in this region, apparently associated with chronic graft-versus-host disease. Few reports have described a secondary solid malignancy involving the oral cavity of young adults after bone marrow transplantation.
Otsubo
H
H
Department of Oral Surgery, School of Medicine, Chiba University.
Yokoe
H
H
Miya
T
T
Atsuta
F
F
Miura
N
N
Tanzawa
H
H
Sato
K
K
D000328:Adult; D000741:Anemia, Aplastic / Q000628:therapy; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D002294:Carcinoma, Squamous Cell / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D005260:Female; D005887:Gingival Neoplasms / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D006086:Graft vs Host Disease / Q000150:complications* / Q000209:etiology; D006801:Humans; D016609:Neoplasms, Second Primary / Q000209:etiology*