Quantitative estimation of retinal nerve fiber layer height in glaucoma and the relationship with optic nerve head topography and visual field.
OBJECTIVE
The authors estimated the retinal nerve fiber layer height (RNFLH) measurements in patients with glaucoma compared with those in age-matched healthy subjects as obtained by the laser scanning tomography and assessed the relationship between RNFLH measurements and optic and visual field status.


METHODS
Parameters of optic nerve head topography and RNFLH were evaluated in 125 eyes of 21 healthy subjects and 104 patients with glaucoma using the Heidelberg Retina Tomograph ([HRT] Heidelberg Engineering GmbH, Heidelberg, Germany) for the entire disc area and for the superior 70 degrees (50 degrees temporal and 20 degrees nasal to the vertical midline) and inferior 70 degrees sectors of the optic disc. The mean deviation of the visual field, as determined by the Humphrey program 24-2 (Humphrey Instruments, Inc., San Leonardo, CA, U.S.A) was calculated in the entire field and in the superior and inferior Bjerrum area.


RESULTS
Retinal nerve fiber layer height parameters (mean RNFLH and RNFL cross-sectional area) were decreased significantly in patients with glaucoma compared with healthy individuals. Retinal nerve fiber layer height parameters was correlated strongly with rim volume, rim area, and cup/disc area ratio. Of the various topography measures, retinal nerve fiber layer (RNFL) parameters and cup/disc area ratio showed the strongest correlation with visual field mean deviation in patients with glaucoma.


CONCLUSIONS
Retinal nerve fiber layer height measures were reduced substantially in patients with glaucoma compared with age-matched healthy subjects. Retinal nerve fiber layer height was correlated strongly with topographic optic disc parameters and visual field changes in patients with glaucoma.
Eid
T M
TM
William and Anna Goldberg Glaucoma Service, Wills Eye Hospital, Jefferson Medical College, Philadelphia, Pennsylvania 19107, U.S.A.
Spaeth
G L
GL
Katz
L J
LJ
Azuara-Blanco
A
A
Agusburger
J
J
Nicholl
J
J
D005260:Female; D005901:Glaucoma / Q000473:pathology*; D006801:Humans; D007834:Lasers; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology*; D009898:Optic Disk / Q000473:pathology*; D009900:Optic Nerve / Q000473:pathology; D012160:Retina / Q000473:pathology*; D014054:Tomography / Q000295:instrumentation; D014794:Visual Fields