title: A biopolymer by any other name would bind as well: a comparison of the ligand-binding pockets of nucleic acids and proteins.
abstract: Crystal structures have recently been reported for several in vitro selected aptamers that bind small molecules. A structural comparison of these aptamers with proteins that bind identical ligands reveals similar strategies for forming ligand-binding pockets.
authors.affiliation: Department of Chemistry, Indiana University, Bloomington 47405, USA.
authors.forename: K A
authors.initials: KA
authors.lastname: Marshall
authors.forename: M P
authors.initials: MP
authors.lastname: Robertson
authors.forename: A D
authors.initials: AD
authors.lastname: Ellington
mesh_terms: D000241:Adenosine / Q000737:chemistry / Q000378:metabolism; D001665:Binding Sites; D001704:Biopolymers / Q000737:chemistry / Q000378:metabolism*; D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D009696:Nucleic Acids / Q000737:chemistry / Q000378:metabolism*; D011487:Protein Conformation; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism*; D012313:RNA / Q000737:chemistry / Q000378:metabolism*
chemical_list: D001704:Biopolymers; D009696:Nucleic Acids; D011506:Proteins; D012313:RNA; D000241:Adenosine