A database for evaluating the toxicological risk of pesticides.
This study of Overtox-DB, a computerized database for managing chemical toxicity data, is a product of the application of typical methodologies regarding information science and computer technology. The methodology applied can be reduced to three-basic elements: the collection of requirements, design, and achievement. Overtox-DB was developed by defining technological elements for managing data and its structure and by identifing the procedures and methodologies for data storage, retrieval, distribution, and standardization of many kinds of test data stored in the same format. The program stores data about chemical identification, physical and chemical properties, toxicological tests, mutagenicity, teratogenicity, carcinogenicity, and a bibliography of chemical compounds. Overtox-DB consists of five modules: experimental and bibliographic, data collection, molecular data collection, data search, and data report. The Overtox-DB user responds to a simplified set of query commands and boolean operators that interact with the system to retrieve different toxicological data (the majority of fields are defined as search fields and identify the test system, results of the assays, administration route, dose, etc.). The collected information provides an analytical characterization of biological activities for many compounds and identifies evidence possibly lacking in experimental approaches. Indeed, this database could permit a comparative evaluation with other substances and can be used for structure-activity relationship studies.
Mazzullo
M
M
Cancer Institute, University of Bologna, Italy.
Mesirca
R
R
Paolini
M
M
Cantelli-Forti
G
G
Perocco
P
P
Ciaccia
P
P
Grilli
S
S
D003628:Database Management Systems; D015394:Molecular Structure; D010575:Pesticides / Q000737:chemistry / Q000633:toxicity*; D018570:Risk Assessment
D010575:Pesticides