title: Patchy cecal inflammation associated with distal ulcerative colitis: a prospective endoscopic study.
abstract: OBJECTIVE
  It is generally believed that the mucosal inflammation in ulcerative colitis is characterized by a diffuse, continuous involvement starting from the rectum without "skip areas." It was the aim of this study to examine 20 patients with established "left-sided ulcerative colitis" prospectively by ileocolonoscopy with biopsies to determine the extent and the continuity of the mucosal inflammation and the incidence of skip lesions in ulcerative colitis.
  
  
  METHODS
  Twenty patients with left-sided ulcerative colitis underwent a complete ileocolonoscopy with biopsies of the terminal ileum and all colonic segments. The patients remained in clinical follow-up for at least 8 yr after the initial examination.
  
  
  RESULTS
  The upper margin of inflammation was sharply demarcated in 6 patients and gradual in 14. Segmental inflammation, separated from the distal inflamed segment by apparently uninvolved mucosa, was found in 15 patients (75%) and always included the area around the appendiceal orifice. The correlation between endoscopic abnormalities and histological changes was excellent.
  
  
  CONCLUSIONS
  In so-called "left-sided" ulcerative colitis distal involvement may be accompanied by more proximal areas of inflammation, particularly in the periappendiceal area of the cecum.
authors.affiliation: Department of Internal Medicine, University Hospital Gasthuisberg, Leuven, Belgium.
authors.forename: G
authors.initials: G
authors.lastname: D'Haens
authors.forename: K
authors.initials: K
authors.lastname: Geboes
authors.forename: M
authors.initials: M
authors.lastname: Peeters
authors.forename: F
authors.initials: F
authors.lastname: Baert
authors.forename: N
authors.initials: N
authors.lastname: Ectors
authors.forename: P
authors.initials: P
authors.lastname: Rutgeerts
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002432:Cecum / Q000473:pathology*; D003093:Colitis, Ulcerative / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology*; D003106:Colon / Q000473:pathology; D003424:Crohn Disease / Q000175:diagnosis; D003937:Diagnosis, Differential; D016099:Endoscopy, Gastrointestinal; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011349:Proctitis / Q000473:pathology; D011446:Prospective Studies; D012007:Rectum / Q000473:pathology