Beclomethasone dipropionate administration via cecostomy in ulcerative colitis.
Beclomethasone dipropionate was administered via a cecostomy to four patients with active ulcerative colitis that was refractory to conventional glucocorticosteroid therapy. From a tube cecostomy, beclomethasone dipropionate solution was administered continuously throughout the day. Clinical manifestations, laboratory examinations, and endoscopic and/or radiographic findings markedly improved within 1-2 wk. A serial decrease in the index of disease activity was observed from the time administration began (mean score, 226.0) to 2 wk later (137.4 points). An excellent clinical response was recognized without any significant side effects, and the urgent need for total colectomy was avoided in all four patients.
Matake
H
H
Department of Gastroenterology, Chikushi Hospital, Fukuoka University, Chikushino, Japan.
Matsui
T
T
Yao
T
T
Sakurai
T
T
Hirai
F
F
Nagae
T
T
Takaki
Y
Y
Arima
S
S
Imamura
T
T
D000328:Adult; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D001507:Beclomethasone / Q000008:administration & dosage*; D002431:Cecostomy; D003093:Colitis, Ulcerative / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged
D000893:Anti-Inflammatory Agents; D001507:Beclomethasone