title: Actions of FMRFamide-related peptides on the gCa2+ of the C1 neuron in Helix aspersa.
abstract: The endogenous neuropeptides FMRFamide and FLRFamide (tetrapeptides) reversibly reduced a voltage-activated calcium current in the C1 neuron of Helix aspersa by an average of 20%. Two structurally related heptapeptides, pQDPFLRFamide and pQDPFLRIamide, both derived from another precursor protein in this species, did not reduce the current at all.
authors.affiliation: University of St. Andrews, Fife, Scotland.
authors.forename: W
authors.initials: W
authors.lastname: Lesser
authors.forename: S W
authors.initials: SW
authors.lastname: Falconer
authors.forename: G A
authors.initials: GA
authors.lastname: Cottrell
mesh_terms: D000818:Animals; D015220:Calcium Channels / Q000187:drug effects* / Q000378:metabolism; D004744:Enkephalin, Methionine / Q000031:analogs & derivatives / Q000494:pharmacology; D005071:Evoked Potentials / Q000187:drug effects; D019835:FMRFamide / Q000031:analogs & derivatives* / Q000494:pharmacology; D006372:Helix, Snails; D009474:Neurons / Q000187:drug effects* / Q000378:metabolism; D009479:Neuropeptides / Q000494:pharmacology; D009842:Oligopeptides / Q000494:pharmacology; D011761:Pyrrolidonecarboxylic Acid / Q000031:analogs & derivatives
chemical_list: D015220:Calcium Channels; D009479:Neuropeptides; D009842:Oligopeptides; D004744:Enkephalin, Methionine; D019835:FMRFamide; C033460:enkephalin-Met, Arg(6)-PheNH2(7)-; C066148:phenylalanyl-leucyl-arginyl phenylalaninamide; C054497:pyroglutamyl-aspartyl-prolyl-phenylalanyl-leucyl-arginyl-phenylalaninamide; D011761:Pyrrolidonecarboxylic Acid