Behaviour of IgG antibody avidity for the antigen and of IgA antibody in active cytomegalovirus, Epstein-Barr virus, herpes simplex virus and human herpes virus 6 infections. Adaptation of a commercial test.
The clinical value of specific IgA and IgG antibody avidity to herpes simplex virus, cytomegalovirus, Epstein-Barr virus and human herpes virus 6 for the detection of active disease and primary infection, respectively, was evaluated. The IgG avidity test, with a break point of 55%, for the detection of primary infection, and of the IgA test for the detection of disease, were associated with a sensitivity of 97% and 64%, respectively; specificity of 100% and 82%; a positive predictive value of 100% and 76%; and a negative predictive value of 96% and 72%, respectively.
Gutiérrez
J
J
Department of Microbiology, Universitary Hospital San Cecilio, University of Granada, Spain.
Rodríguez
M
M
Maroto
M C
MC
Piédrola
G
G
Peirón
J
J
D000328:Adult; D000915:Antibody Affinity; D000942:Antigens, Bacterial / Q000276:immunology*; D002675:Child, Preschool; D003587:Cytomegalovirus / Q000276:immunology; D006564:Herpesviridae / Q000276:immunology*; D006566:Herpesviridae Infections / Q000175:diagnosis* / Q000276:immunology; D004854:Herpesvirus 4, Human / Q000276:immunology; D015654:Herpesvirus 6, Human / Q000276:immunology; D006801:Humans; D007070:Immunoglobulin A / Q000276:immunology*; D007074:Immunoglobulin G / Q000276:immunology*; D012680:Sensitivity and Specificity; D012698:Serologic Tests / Q000379:methods; D018139:Simplexvirus / Q000276:immunology
D000942:Antigens, Bacterial; D007070:Immunoglobulin A; D007074:Immunoglobulin G