title: Assignment of the human gene for KBF2/RBP-Jk to chromosome 9p12-13 and 9q13 by fluorescence in situ hybridization.
abstract: The transcription factor KBF2 has been characterized as a factor that binds to the NFkB site of mouse major histocompatibility complex (MHC) class I genes and its amino acid sequence has been shwn to be identical to those of members of the recombination signal-sequence binding protein (RBP-Jk) family. Previous studies by Amakawa et al. (Genomics 17, 306-315, 1993) demonstrated that the functional gene is localized at human chromosome 3q25. However, in the present study we showed by in situ hybridization with the functional KBF2/RBPJk cosmid clone that the gene is localized at 9p12-13 and 9q13, namely, at the same loci as pseudogenes that were reported previously (Zhang et al, Jpn J Human Genet 39, 391-401, 1994).
authors.affiliation: Tsukuba Life Science Center, Institute of Physical and Chemical Research (RIKEN), Ibaraki, Japan.
authors.forename: X
authors.initials: X
authors.lastname: Tang
authors.forename: F
authors.initials: F
authors.lastname: Saito-Ohara
authors.forename: J
authors.initials: J
authors.lastname: Song
authors.forename: C
authors.initials: C
authors.lastname: Koga
authors.forename: H
authors.initials: H
authors.lastname: Ugai
authors.forename: H
authors.initials: H
authors.lastname: Murakami
authors.forename: T
authors.initials: T
authors.lastname: Ikeuchi
authors.forename: K K
authors.initials: KK
authors.lastname: Yokoyama
mesh_terms: D000818:Animals; D002899:Chromosomes, Human, Pair 9; D003360:Cosmids; D004268:DNA-Binding Proteins / Q000235:genetics*; D006801:Humans; D051819:Immunoglobulin J Recombination Signal Sequence-Binding Protein; D017404:In Situ Hybridization, Fluorescence; D051379:Mice; D009687:Nuclear Proteins; D014157:Transcription Factors / Q000235:genetics
chemical_list: D004268:DNA-Binding Proteins; D051819:Immunoglobulin J Recombination Signal Sequence-Binding Protein; D009687:Nuclear Proteins; C497570:RBPJ protein, human; C497571:Rbpj protein, mouse; D014157:Transcription Factors