title: Infectious posterior scleritis caused by Pseudallescheria boydii. Clinicopathologic findings.
abstract: OBJECTIVE
  The purpose of the study is to describe an unusual case of infectious posterior scleritis after excision of a pterygium.
  
  
  METHODS
  The case history of a patient in whom anterior and posterior scleritis developed after excision of a pterygium is reviewed. Histopathologic findings are presented.
  
  
  RESULTS
  Pathologic examination results of a scleral biopsy site and the eye showed extensive involvement of the posterior sclera with fungi that on culture grew Pseudallescheria boydii. The development of posterior scleral thickening and intrascleral abscesses gave the clinical impression of autoimmune posterior scleritis or possible tumor. Ultrasonography and computed tomography scan of the eye and orbit proved particularly helpful in following progression of scleral involvement.
  
  
  CONCLUSIONS
  Pseudallescheria boydii is capable of causing an infectious posterior scleritis, which can mimic autoimmune posterior scleritis. The use of systemic immunosuppressive agents contributed to this unusual clinical presentation. Progression of posterior scleritis in the face of apparent adequate immunosuppressive therapy always should suggest the possibility of tumor or infection.
authors.affiliation: Department of Ophthalmology, University of Colorado Health Sciences Center, Denver, USA.
authors.forename: M J
authors.initials: MJ
authors.lastname: Taravella
authors.forename: D W
authors.initials: DW
authors.lastname: Johnson
authors.forename: J G
authors.initials: JG
authors.lastname: Petty
authors.forename: R B
authors.initials: RB
authors.lastname: Keyser
authors.forename: C S
authors.initials: CS
authors.lastname: Foster
authors.forename: B E
authors.initials: BE
authors.lastname: Lundberg
mesh_terms: D000368:Aged; D015353:Eye Enucleation; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects; D008297:Male; D008271:Mycetoma / Q000175:diagnosis / Q000473:pathology / Q000628:therapy; D011541:Pseudallescheria; D011625:Pterygium / Q000601:surgery; D012590:Sclera / Q000473:pathology; D015423:Scleritis / Q000175:diagnosis / Q000382:microbiology* / Q000473:pathology; D013530:Surgical Wound Infection / Q000382:microbiology; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography
chemical_list: D007166:Immunosuppressive Agents