title: Assessment of regional left ventricular wall parameters from short axis magnetic resonance imaging using a three-dimensional extension to the improved centerline method.
abstract: OBJECTIVE
  Short-axis magnetic resonance images of the cardiac left ventricle, acquired in multiple slices and phases, may be used for the quantitative assessment of regional wall parameters. Conventional two-dimensional (2-D) methods for wall thickness measurement rely on information within one imaging plane, which may result in overestimation of the true thickness depending on the local direction of myocardial wall with respect to the imaging plane.
  
  
  METHODS
  To perform wall thickness measurements truly perpendicular to the myocardial wall, a three-dimensional (3-D) wall thickness calculation algorithm has been developed based on the 2-D improved centerline method. An evaluation was performed on left ventricular-shaped software phantoms, and on the magnetic resonance (MR) imaging data obtained from 20 healthy individuals.
  
  
  RESULTS
  The 3-D method applied to software phantoms with an angulation within 20 degrees of the true short-axis orientation demonstrated only a 1.6% overestimation of wall thickness at the mid to low slices, and a 10.6% error at the apex (2-D measurements: 8.1% and 28.6%, respectively). Three-dimensionally calculated wall thickness in the healthy individuals was systematically and significantly smaller than corresponding 2-D wall thickness (by 11.2%, 8.7%, and 2.6% at the apical, low, and mid slices, respectively).
  
  
  CONCLUSIONS
  Cardiac wall thickness measurements from short-axis MR studies can be obtained with a higher accuracy by the newly developed 3-D approach than with the conventional 2-D approach.
authors.affiliation: Department of Radiology, Leiden University Medical Centre, The Netherlands.
authors.forename: V G
authors.initials: VG
authors.lastname: Buller
authors.forename: R J
authors.initials: RJ
authors.lastname: van der Geest
authors.forename: M D
authors.initials: MD
authors.lastname: Kool
authors.forename: E E
authors.initials: EE
authors.lastname: van der Wall
authors.forename: A
authors.initials: A
authors.lastname: de Roos
authors.forename: J H
authors.initials: JH
authors.lastname: Reiber
mesh_terms: D000328:Adult; D000368:Aged; D003198:Computer Simulation; D006352:Heart Ventricles / Q000033:anatomy & histology*; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008875:Middle Aged; D008955:Models, Cardiovascular