Hormonal changes associated with menstrual cycle have no definite influence on ocular pressure.
BACKGROUND
Despite some findings to the contrary, it would appear that pharmacological doses of progesterone and estrogen (alone or in combination) can influence intraocular pressure (IOP). The relationship between hormonal changes associated with the menstrual cycle and intraocular pressure is not clearly understood. After elimination of those factors that can affect IOP, the present study investigated whether physiological hormonal changes associated with the menstrual cycle have a correlation with intraocular pressure.


METHODS
Intraocular pressure and the concentrations of circulating hormones, namely, the luteinizing hormone (LH), follicle-stimulating hormone (FSH), estrone (E1), estradiol (E2), progesterone, and testosterone, of twenty married women of the same age groups were recorded daily throughout a menstrual cycle. None was taking any contraceptives in any form. The intraocular pressure was measured using a Goldmann applanation tonometer.


RESULTS
The intraocular pressure values fluctuated in each of the twenty subjects at various times of the cycle; however, they were not definitely correlated with the different phases of the cycle. This study failed to find any correlation between IOP and progesterone or estradiol levels.
Qureshi
I A
IA
Department of Physiology, Rawalpindi Medical College, Pakistan.
Huang
Y B
YB
Xi
X R
XR
Wu
X D
XD
D000328:Adult; D004958:Estradiol / Q000097:blood; D004967:Estrogens / Q000502:physiology*; D004970:Estrone / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007429:Intraocular Pressure; D007986:Luteinizing Hormone / Q000097:blood; D008597:Menstrual Cycle / Q000502:physiology*; D010061:Ovulation Detection; D011374:Progesterone / Q000097:blood / Q000502:physiology*; D011863:Radioimmunoassay; D013739:Testosterone / Q000097:blood; D014065:Tonometry, Ocular
D004967:Estrogens; D004970:Estrone; D013739:Testosterone; D011374:Progesterone; D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone