title: Steroid-responsive, cervical, pyogranulomatous pachymeningitis in a dog.
abstract: Syndromes of steroid-responsive meningitis have been described in the dog and typically are characterized by neutrophilic pleocytosis and an elevated protein concentration of the cerebrospinal fluid. In a minority of cases, histopathology has demonstrated suppurative leptomeningeal (i.e., arachnoid and pia) inflammation. A case of compressive, cervical, pyogranulomatous inflammation of undetermined cause affecting the dura mater (i.e., pachymeningitis), accompanied by fever and hyperpathia, is presented. The pachymeningitis ultimately regressed with long-term immunosuppressive therapy. This case shares features with hypertrophic spinal pachymeningitis of humans, an uncommon, frequently idiopathic, chronic inflammatory disorder causing dural hypertrophy, radiculopathy, and spinal cord compression.
authors.affiliation: Department of Companion Animal and Special Species Medicine, College of Veterinary Medicine, North Carolina State University, Raleigh 27606, USA.
authors.forename: P R
authors.initials: PR
authors.lastname: Hess
authors.forename: R K
authors.initials: RK
authors.lastname: Sellon
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology; D004285:Dogs; D004388:Dura Mater / Q000473:pathology; D005260:Female; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008581:Meningitis / Q000175:diagnosis / Q000188:drug therapy / Q000662:veterinary*; D011241:Prednisone / Q000627:therapeutic use*; D011859:Radiography; D013117:Spinal Cord Compression / Q000209:etiology / Q000662:veterinary; D013131:Spine / Q000000981:diagnostic imaging / Q000473:pathology
chemical_list: D007166:Immunosuppressive Agents; D011241:Prednisone