Cell polarity: par for the polar course.
The nematode PAR-1 gene is required for asymmetric cell divisions during development. Recently identified mammalian Par-1 homologues are kinases that phosphorylate microtubule-associated proteins; their overexpression disrupts the microtubule cytoskeleton, and alters cellular structure and organization.
Nelson
W J
WJ
Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, California 94305-5426, USA. wjnelson@leland.stanford.edu
Grindstaff
K K
KK
D000818:Animals; D017173:Caenorhabditis elegans; D016764:Cell Polarity; D004268:DNA-Binding Proteins / Q000502:physiology*; D008954:Models, Biological; D029701:Saccharomyces cerevisiae Proteins; D014157:Transcription Factors / Q000502:physiology*
D004268:DNA-Binding Proteins; D029701:Saccharomyces cerevisiae Proteins; D014157:Transcription Factors; C086677:YAP1 protein, S cerevisiae