title: Three cases of fatal pulmonary embolism in obstetrics.
abstract: We conducted a retrospective analysis of maternal deaths in our hospital from January 1992 to December 1995. Cases of fatal pulmonary embolism were identified and analysed with respect to their past history, antenatal and peripartum progress, clinical presentation and investigation. There were 7 maternal deaths during this period and autopsies were performed in all cases. Pulmonary embolism was the leading cause of maternal mortality, responsible for 3 deaths. The incidence of fatal pulmonary embolism was 4.9 per 100,000 maternities. One case occurred antepartum and 2 occurred postpartum. The antepartum case occurred after a period of immobilisation, and both postpartum cases occurred after emergency Caesarean sections. Dyspnoea and sudden cardiovascular collapse were the commonest presentations. Electrocardiograph and arterial blood gases were abnormal in both patients in whom the tests were performed. Death occurred within 11 hours of presentation of symptoms in all 3 cases. Pulmonary embolism was more common among our population than previously reported, and was the leading cause of maternal mortality in our institution over the last 4 years. Immobilisation and Caesarean section were the major risk factors. Identification of high risk situation, antithrombotic prophylaxis and a high degree of suspicion were the key to reducing the incidence of fatal pulmonary embolism in obstetric patients.
authors.affiliation: Department of Maternal Fetal Medicine, K K Women's and Children's Hospital, Singapore.
authors.forename: L H
authors.initials: LH
authors.lastname: Chen
authors.forename: C T
authors.initials: CT
authors.lastname: Yeong
authors.forename: G S
authors.initials: GS
authors.lastname: Yeo
mesh_terms: D000328:Adult; D002585:Cesarean Section / Q000009:adverse effects; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis / Q000401:mortality; D011655:Pulmonary Embolism / Q000175:diagnosis / Q000401:mortality; D012307:Risk Factors; D012846:Singapore / Q000453:epidemiology