N-acetylcysteine protects against age-related increase in oxidized proteins in mouse synaptic mitochondria.
Since it has been proposed that oxidized protein accumulation plays a critical role in brain aging, we have investigated the effect of a thiolic antioxidant on protein carbonyl content in synaptic mitochondria from female OF-1 mice. At 48 weeks of age, a control group was fed standard food pellets and another group received pellets containing 0.3% (w/w) of N-acetylcysteine. A 24-week treatment resulted in a significant decrease in protein carbonyl content in synaptic mitochondria of the N-acetylcysteine-treated animals as compared to age-matched controls.
Banaclocha
M M
MM
Departamento de Anatomía Patológica, Hospital La Paz, Madrid, Spain.
Hernández
A I
AI
Martínez
N
N
Ferrándiz
M L
ML
D000111:Acetylcysteine / Q000494:pharmacology*; D000375:Aging / Q000378:metabolism*; D000818:Animals; D005260:Female; D016166:Free Radical Scavengers / Q000494:pharmacology*; D005978:Glutathione / Q000032:analysis / Q000378:metabolism; D051379:Mice; D008815:Mice, Inbred Strains; D008928:Mitochondria / Q000737:chemistry / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism / Q000648:ultrastructure; D010084:Oxidation-Reduction; D013438:Sulfhydryl Compounds / Q000378:metabolism; D013569:Synapses / Q000648:ultrastructure*
D016166:Free Radical Scavengers; D013438:Sulfhydryl Compounds; D005978:Glutathione; D000111:Acetylcysteine