Effects of 5-HT3 receptor agonists on voluntary ethanol intake in rats maintained on a limited access procedure.
Recent evidence from a variety of laboratory studies suggests that the central effects of ethanol (EtOH) are mediated by serotonin 5-HT3 receptors. Notably, EtOH is able to potentiate 5-HT action on 5-HT3 ionophore, and 5-HT3 antagonists are known to reduce certain effects of EtOH. In the present study, we evaluated the effects of two agonists of 5-HT3 receptors, 2-methyl-5-HT (2-Me-5-HT) and m-chlorophenylbiguanide (m-CPBG) that were microinjected i.c.v. and into the nucleus accumbens (NAC) on EtOH intake in Wistar rats with high EtOH preference. 2-Me-5-HT given i.c.v. (1 and 10 microg per rat) and into the NAC (bilaterally 1 and 10 microg per site) significantly reduced EtOH intake in the limited access paradigm (2h session). On the other hand m-CPBG was inactive after intra-NAC administration. It is concluded that central 5-HT3 receptors are involved in the regulation of EtOH consumption.
Dyr
W
W
Department of Pharmacology and Physiology of the Nervous System, Institute of Psychiatry and Neurology, Warszawa, Poland.
Kostowski
W
W
D000428:Alcohol Drinking; D000818:Animals; D001645:Biguanides / Q000008:administration & dosage / Q000494:pharmacology*; D002490:Central Nervous System / Q000187:drug effects / Q000502:physiology; D002492:Central Nervous System Depressants / Q000008:administration & dosage / Q000494:pharmacology*; D000431:Ethanol / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D011985:Receptors, Serotonin / Q000502:physiology*; D012701:Serotonin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D017366:Serotonin Receptor Agonists / Q000494:pharmacology*
D001645:Biguanides; D002492:Central Nervous System Depressants; D011985:Receptors, Serotonin; D017366:Serotonin Receptor Agonists; D012701:Serotonin; D000431:Ethanol; C045918:2-methyl-5-HT; C065734:1-(3-chlorophenyl)biguanide