title: Comparison of patients with early-, typical-, and late-onset affective psychosis.
abstract: OBJECTIVE
  The authors compared the clinical characteristics and family history of patients with early-onset (before age 18), typical-onset (at 20-25 years), and late-onset (after age 35) affective psychosis at the time of first hospitalization.
  
  
  METHODS
  Diagnostic, symptom, and family history information was obtained from 88 consecutively hospitalized patients.
  
  
  RESULTS
  Major depression was more common in the late-onset group, and a family history of affective and substance abuse disorders was more common among the early-onset patients. Affective symptoms differed significantly among groups; specifically, early-onset patients had more energy, minimal sleep disruption, and greater suicidality, while typical-onset patients had more severe abnormal thought content.
  
  
  CONCLUSIONS
  Among patients with affective psychosis, there may be heterogeneity of symptoms and family history associated with age at first hospitalization.
authors.affiliation: Department of Psychiatry, University of Cincinnati College of Medicine, OH, USA. saxkw@email.uc.edu
authors.forename: K W
authors.initials: KW
authors.lastname: Sax
authors.forename: S M
authors.initials: SM
authors.lastname: Strakowski
authors.forename: P E
authors.initials: PE
authors.lastname: Keck
authors.forename: S L
authors.initials: SL
authors.lastname: McElroy
authors.forename: S A
authors.initials: SA
authors.lastname: West
authors.forename: M L
authors.initials: ML
authors.lastname: Bourne
authors.forename: E R
authors.initials: ER
authors.lastname: Larson
mesh_terms: D000293:Adolescent; D000328:Adult; D000341:Affective Disorders, Psychotic / Q000175:diagnosis* / Q000453:epidemiology / Q000523:psychology; D017668:Age of Onset; D001714:Bipolar Disorder / Q000175:diagnosis / Q000453:epidemiology / Q000523:psychology; D015897:Comorbidity; D003866:Depressive Disorder / Q000175:diagnosis / Q000453:epidemiology / Q000523:psychology; D005190:Family; D005260:Female; D006760:Hospitalization; D006801:Humans; D008297:Male; D015995:Prevalence; D011569:Psychiatric Status Rating Scales; D012720:Severity of Illness Index; D012893:Sleep Wake Disorders / Q000175:diagnosis / Q000453:epidemiology; D019966:Substance-Related Disorders / Q000175:diagnosis / Q000453:epidemiology; D013405:Suicide / Q000523:psychology / Q000706:statistics & numerical data