Histological examinations of the influence of 6-hydroxydopamine (6-OH-DA) upon the ileum of the guinea pig.
Examinations of the influence of 6-OH-DA (6-hydroxydopamine) upon the structure of nerve cells and their axons have been conducted by many authors and in various aspects (1, 2, 8, 10). They have concerned histochemistry, fluorescence and ultrastructure of neurons and have shown that the substance evokes various changes in the perikaryons and axons of adrenergic neurons. The wall of the small intestine is innervated by external autonomyous nerves and fibres of the intramural autonomyous plexuses. External autonomyous fibres make numerous anastomoses with the neurons of the two intramural plexuses and ganglia: the myenteric one (Auerbach's) and the submucosal one (Meissner's) (6). Both ganglia run along the length of the intestine and their neurons apart from making anastomoses, send axons to the nonstrained muscles cells and glandular cells in the mucosa. As a consequence, the active phase is easily carried over along the alimentary system stimulating action of nonstrained muscles and glandular cells. 6-OH-DA exerts strong action upon the nerve cells and ends, that is why we have decided to examine the changes taking place in the ileum when the substance starts to operate.
Majewska
T
T
Katedra i Zakład Histologii i Embriologii z Pracowniä Cytologii Doświadczalnej, Akademia Medyczna w Lublinie.
Królikowska-Prasał
I
I
Lańcut
M
M
Budzyńska
B
B
D000818:Animals; D005724:Ganglia / Q000187:drug effects / Q000473:pathology; D005753:Gastric Mucosa / Q000187:drug effects / Q000473:pathology; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects* / Q000294:innervation / Q000473:pathology; D007274:Injections, Intraperitoneal; D009197:Myenteric Plexus / Q000187:drug effects / Q000473:pathology; D009474:Neurons / Q000187:drug effects / Q000473:pathology; D016627:Oxidopamine / Q000494:pharmacology*; D013565:Sympatholytics / Q000494:pharmacology*
D013565:Sympatholytics; D016627:Oxidopamine