Calcium signalling: how do IP3 receptors work?
The intracellular receptor for inositol 1,4,5-trisphosphate (IP3) is responsible for generation and control of very complex Ca2+ signals. New experimental approaches to studying the kinetics of the IP3 receptor are now beginning to give some insight into the mechanisms behind its rather bizarre properties.
Dawson
A P
AP
School of Biological Sciences, University of East Anglia, Norwich, NR4 7TJ, UK.
D000818:Animals; D002118:Calcium / Q000502:physiology*; D015220:Calcium Channels / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D015544:Inositol 1,4,5-Trisphosphate / Q000378:metabolism; D053496:Inositol 1,4,5-Trisphosphate Receptors; D007700:Kinetics; D008958:Models, Molecular; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*
D015220:Calcium Channels; C506926:ITPR1 protein, human; D053496:Inositol 1,4,5-Trisphosphate Receptors; D018160:Receptors, Cytoplasmic and Nuclear; D015544:Inositol 1,4,5-Trisphosphate; D002118:Calcium