Multiorgan system failure caused by valproic acid toxicity.
Valproic acid is an effective antiseizure medication that is also used for other indications such as migraine prophylaxis. It is known to sometimes cause hepatic injury, both a mild dose-related form and an idiosyncratic, fulminant, usually fatal type. A case is reported of multiorgan failure caused by valproic acid toxicity in an adult who survived. Such multisystem toxicity has not been previously reported.
Pinkston
R
R
Department of Emergency Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Walker
L A
LA
D058186:Acute Kidney Injury / Q000139:chemically induced; D000927:Anticonvulsants / Q000506:poisoning* / Q000627:therapeutic use; D004630:Emergencies; D006801:Humans; D017093:Liver Failure / Q000139:chemically induced; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000188:drug therapy; D009102:Multiple Organ Failure / Q000139:chemically induced*; D010195:Pancreatitis / Q000139:chemically induced; D012206:Rhabdomyolysis / Q000139:chemically induced; D014635:Valproic Acid / Q000506:poisoning* / Q000627:therapeutic use
D000927:Anticonvulsants; D014635:Valproic Acid