title: Premenstrual syndrome: current perspectives on treatment and etiology.
abstract: In the past year, randomized controlled clinical trials of treatments for clearly diagnosed premenstrual syndrome reported efficacy for serotonergic antidepressants and a gonadotropin-releasing hormone agonist. Preliminary data suggested efficacy for spironolactone and a carbohydraterich beverage. Several neuroendocrine studies have contributed to a growing list of findings that suggest an underlying neurobiological vulnerability in premenstrual syndrome.
authors.affiliation: Department of Obstetrics/Gynecology, University of Pennsylvania Medical Center, Philadelphia 19104, USA.
authors.forename: E W
authors.initials: EW
authors.lastname: Freeman
mesh_terms: D000818:Animals; D014151:Anti-Anxiety Agents / Q000627:therapeutic use; D000928:Antidepressive Agents / Q000627:therapeutic use; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000819:agonists; D006801:Humans; D011293:Premenstrual Syndrome / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology; D016896:Treatment Outcome
chemical_list: D014151:Anti-Anxiety Agents; D000928:Antidepressive Agents; D007987:Gonadotropin-Releasing Hormone