title: Identification of pericentric inversion 12, inv(12)(p13.1q11), by fluorescence in situ hybridization in a patient with acute myeloid leukemia (AML-M6).
abstract: Using probes located between 12p12.1 and 12p13.3, we performed fluorescence in situ hybridization (FISH) analysis and identified an inv(12)(p13.1q11) in a patient with acute myeloid leukemia (AML-M6). Standard cytogenetic analysis had identified the rearranged chromosomes 12 as del(12) (p11p13). Although deletions and translocations involving band 12p13 are fairly common chromosomal abnormalities observed in a broad spectrum of hematologic malignancies, inv(12) is a rather rare abnormality. We compare the clinical and cytogenetic findings with those of the previous cases reported in the literature.
authors.affiliation: Section of Hematology/Oncology, University of Chicago, IL 60637, USA.
authors.forename: Y
authors.initials: Y
authors.lastname: Sato
authors.forename: S K
authors.initials: SK
authors.lastname: Bohlander
authors.forename: H
authors.initials: H
authors.lastname: Kobayashi
authors.forename: Y
authors.initials: Y
authors.lastname: Suto
authors.forename: E M
authors.initials: EM
authors.lastname: Davis
authors.forename: R
authors.initials: R
authors.lastname: Espinosa
authors.forename: M M
authors.initials: MM
authors.lastname: Le Beau
authors.forename: J D
authors.initials: JD
authors.lastname: Rowley
mesh_terms: D002871:Chromosome Banding; D007446:Chromosome Inversion; D002874:Chromosome Mapping; D002881:Chromosomes, Human, Pair 12; D015342:DNA Probes; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D004915:Leukemia, Erythroblastic, Acute / Q000235:genetics*; D008875:Middle Aged
chemical_list: D015342:DNA Probes