title: [Equine motor neuron disease (EMND). A case report].
abstract: A 13-year-old warmblood mare was presented because of progressive weight loss, general weakness and trembling. On examination the horse stood with its head lowered and the limbs placed under the body. On lifting its head spasms of the neck muscles could be observed. At the same time the horse developed trembling over the lower neck and muscle fasciculations continued over the whole body. Additional signs included frequent recumbency, polyphagia and facial hyperaesthesia. The horse showed no signs of ataxia. Haematology was normal. Blood biochemistry revealed slight increased aspartate aminotransferase (AST: 1060 U/I) and creatine kinase levels (CK: 441 U/I). Based on the clinical findings equine motor neuron disease was diagnosed. The horse was euthanatized due to poor prognosis and the progression of symptoms. The typical neurodegenerative changes found on histological examination of the spinal cord confirmed the diagnosis.
authors.affiliation: Klinik für Wiederkäuer- und Pferdemedizin, Universität Zürich.
authors.forename: G
authors.initials: G
authors.lastname: Landolt
authors.forename: K
authors.initials: K
authors.lastname: Feige
authors.forename: P
authors.initials: P
authors.lastname: Grest
mesh_terms: D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D004796:Clinical Enzyme Tests; D003402:Creatine Kinase / Q000097:blood; D005260:Female; D006734:Horse Diseases; D006736:Horses; D016472:Motor Neuron Disease / Q000175:diagnosis / Q000503:physiopathology / Q000662:veterinary*; D018482:Muscle, Skeletal / Q000503:physiopathology; D009474:Neurons / Q000473:pathology; D011187:Posture; D013116:Spinal Cord / Q000473:pathology
chemical_list: D001219:Aspartate Aminotransferases; D003402:Creatine Kinase