From prion diseases to Alzheimer's disease.
Recent advances in the transgenetics of prion diseases and Alzheimer's disease have led to a clearer understanding of the relationship between these two diseases and the pathogenic mechanisms underlying the two disorders. Earlier studies of transgenic mice expressing prion protein (PrP) underscored the importance of PrP levels and PrP primary structure on the resultant phenotype. Three major parameters influencing the phenotypes of mice expressing the Alzheimer amyloid precursor protein (APP) have also been identified: 1) APP levels; 2) APP primary structure; and 3) mouse host strain. The effects and implications of these parameters in transgenic mice expressing APP are discussed.
Hsiao
K K
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Department of Neurology, University of Minnesota, USA.
D000544:Alzheimer Disease / Q000235:genetics / Q000473:pathology / Q000503:physiopathology*; D016564:Amyloid beta-Protein Precursor / Q000235:genetics / Q000378:metabolism; D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic; D017096:Prion Diseases / Q000235:genetics / Q000473:pathology / Q000503:physiopathology*; D011328:Prions / Q000235:genetics / Q000378:metabolism
D016564:Amyloid beta-Protein Precursor; D011328:Prions