title: Evaluation of carbon-11-labelled phenoxy bridged fatty acids for studying myocardial fatty acid metabolism with PET.
abstract: A phenylene moiety in the chain of fatty acids was expected to impair metabolic degradation. Three phenoxy-containing [11C]carboxyl-labelled fatty acids were synthesized and evaluated in mice and an in vivo tissue distribution study. Of these three, 1[11C]-3-(p-dodecyloxyphenyl)propionic acid (C12C3) showed the most favourable uptake in the myocardium: 1.2% of the injected dose at 30 min p.i., vs. 0.6% for [11C]palmitate. The metabolic stability of C12C3 and [11C]palmitate was assessed by determining the amount of exhaled [11C]CO2 during a 30-min interval after injection. It was found that the phenoxy moiety in the gamma-position did not prevent the metabolic degradation of C12C3: After 30 min 20.7% of the injected dose was exhaled as [11C]CO2 vs. 12.7% for [11C]palmitate.
authors.affiliation: Laboratory for Radiopharmaceutical Chemistry FFW, University Hospital Gasthuiseberg, Leuven, Belgium.
authors.forename: T
authors.initials: T
authors.lastname: de Groot
authors.forename: B
authors.initials: B
authors.lastname: Maris
authors.forename: C
authors.initials: C
authors.lastname: Boonen
authors.forename: G
authors.initials: G
authors.lastname: Bormans
authors.forename: L
authors.initials: L
authors.lastname: Mortelmans
authors.forename: M
authors.initials: M
authors.lastname: Eisenhut
authors.forename: A
authors.initials: A
authors.lastname: Verbruggen
mesh_terms: D000818:Animals; D002245:Carbon Dioxide / Q000378:metabolism; D002250:Carbon Radioisotopes; D005227:Fatty Acids / Q000378:metabolism*; D008297:Male; D051379:Mice; D009206:Myocardium / Q000378:metabolism*; D014055:Tomography, Emission-Computed
chemical_list: D002250:Carbon Radioisotopes; D005227:Fatty Acids; D002245:Carbon Dioxide