Suppressive effect of perinatal testes on the differentiation of fetal ovaries transplanted into adult males in the rat.
A 14 d ovarian primordium was transplanted with a fetal testis (13-18 d and 21 d of gestation) or a neonatal testis (15, 20, 30 and 45 d after birth) into the renal subcapsular position of an adult male rat. Two weeks after transplantation, transplants were examined as to the degree of ovarian and testicular differentiation. In the combination of a 14 d ovary and a 13 d testis, there were 3 types of result: either the ovary or the testis alone developed or both gonads developed well. Ovaries transplanted in union with 15-18 d testes did not develop, although the testes developed normally. Some ovaries in union with 21 d testes developed normally. In combination with infantile testes, the incidence of developed ovaries increased as the age of testes advanced. These results suggest that the 13 d fetal testes begin to suppress the development of cotransplanted 14 d ovaries, that 14-18 d fetal testes maintain such suppressive effects and that this effect gradually diminishes in infantile testes as they progress toward 45 d after birth.
Namba
Y
Y
Department of Anatomy II, School of Veterinary Medicine, Azabu University, Sagamihara, Japan.
Yamamoto
M
M
Atrishima
K
K
Eguchi
Y
Y
D000818:Animals; D004627:Embryonic Induction; D005260:Female; D005865:Gestational Age; D008297:Male; D010053:Ovary / Q000166:cytology / Q000196:embryology* / Q000637:transplantation*; D051381:Rats; D017208:Rats, Wistar; D013737:Testis / Q000196:embryology* / Q000637:transplantation*