title: [Non-natural aglycones of glycopeptide antibiotics of the vancomycin group. Synthesis and antibacterial activity].
abstract: A new approach for the modification of the heptapeptide core of glycopeptide antibiotics was proposed based on the replacement of amino acid residues in positions 1 and 3 in teicoplanin aglycone and in position 1 in the eremomycin aglycone. Six novel nonnatural aglycones of the vancomycin type were obtained. Compounds derived from the teicoplanin aglycone exhibited in vitro activity against Gram-positive bacteria, and two of them were also active against the vancomycin-resistant enterococci.
authors.forename: A Iu
authors.initials: AIu
authors.lastname: Pavlov
authors.forename: E N
authors.initials: EN
authors.lastname: Olsuf'eva
authors.forename: O V
authors.initials: OV
authors.lastname: Miroshnikova
authors.forename: M I
authors.initials: MI
authors.lastname: Reznikova
authors.forename: E I
authors.initials: EI
authors.lastname: Lazhko
authors.forename: A
authors.initials: A
authors.lastname: Malabarba
authors.forename: R
authors.initials: R
authors.lastname: Ciabatti
authors.forename: M N
authors.initials: MN
authors.lastname: Preobrazhenskaia
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D014640:Vancomycin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D014640:Vancomycin