[Neuroprotective and neurorestorative therapy in Parkinson's disease].
It has been suggested a possible role of oxidative stress, neuromelanin, mitochondrial dysfunction, calcium-binding protein deficiency, nitric oxide, trophic factors deficiency, and cytokines, in the pathogenesis of Parkinson's disease. Based on these mechanisms it might be established neuroprotective therapies but, up to date, the results reported are inconsistent. Many experimental data suggest the usefulness of some restorative therapy, such as neural grafts, genic therapies, etc. This article reviews the current knowledge on the possible neuroprotective and restorative treatments in Parkinson's disease.
Jiménez-Jiménez
F J
FJ
Departamento de Neurología, Hospital Universitario Príncipe de Asturias, Alcalúa de Henares, Madrid, España.
Molina
J A
JA
D000978:Antiparkinson Agents / Q000494:pharmacology / Q000627:therapeutic use*; D017209:Apoptosis; D016380:Brain Tissue Transplantation; D015913:Chelation Therapy / Q000379:methods*; D003342:Corpus Striatum / Q000187:drug effects; D004298:Dopamine / Q000378:metabolism; D004912:Erythrocytes / Q000187:drug effects; D005609:Free Radicals; D005732:Gangliosides / Q000494:pharmacology / Q000627:therapeutic use*; D015316:Genetic Therapy; D005979:Glutathione Peroxidase / Q000378:metabolism; D006801:Humans; D007980:Levodopa / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D008996:Monoamine Oxidase Inhibitors / Q000627:therapeutic use*; D009474:Neurons / Q000187:drug effects; D018384:Oxidative Stress / Q000187:drug effects; D010300:Parkinson Disease / Q000188:drug therapy* / Q000209:etiology; D012642:Selegiline / Q000627:therapeutic use*; D012643:Selenium / Q000494:pharmacology / Q000627:therapeutic use*; D014810:Vitamin E / Q000494:pharmacology / Q000627:therapeutic use*
D000978:Antiparkinson Agents; D005609:Free Radicals; D005732:Gangliosides; D008996:Monoamine Oxidase Inhibitors; D014810:Vitamin E; D012642:Selegiline; D007980:Levodopa; D005979:Glutathione Peroxidase; D012643:Selenium; D004298:Dopamine