Mitochondrial myopathy in Senna occidentalis-seed-fed chicken.
Plants of the genus Senna (formerly Cassia) have been recognized as the cause of a natural and experimental syndrome of muscle degeneration frequently leading to death in animals. Histologically, it demonstrated skeletal and cardiac muscle necrosis, with floccular degeneration and proliferation of sarcolemmal nuclei. Recently, it was described as an experimental model of mitochondrial myopathy in hens chronically treated with Senna occidentalis. Currently, skeletal muscles of chicks intoxicated with seeds of the poisonous plant S. occidentalis were studied by histochemistry and electron microscopy. Since birth, the birds were fed ground dried seeds of this plant with a regular chicken ration at a dose of 4% for 11 days. Microscopic examination revealed, besides muscle-fiber atrophy, lipid storage in most fibers and a moderate amount of cytochrome oxidase-negative fibers. By electron microscopy, enlarged mitochondria with disrupted or excessively branched cristae were seen. This picture was characteristic of mitochondrial myopathy. These findings have hitherto remained unnoticed in skeletal muscle of young birds treated with S. occidentalis.
Cavaliere
M J
MJ
Section of Pathology, Emflio Ribas Institute, São Paulo, Brazil.
Calore
E E
EE
Haraguchi
M
M
Górniak
S L
SL
Dagli
M L
ML
Raspantini
P C
PC
Calore
N M
NM
Weg
R
R
D000821:Animal Feed / Q000633:toxicity*; D000818:Animals; D001284:Atrophy / Q000139:chemically induced / Q000473:pathology / Q000662:veterinary; D002645:Chickens; D008931:Mitochondria, Muscle / Q000187:drug effects / Q000201:enzymology / Q000648:ultrastructure; D017240:Mitochondrial Myopathies / Q000139:chemically induced / Q000473:pathology / Q000662:veterinary*; D018482:Muscle, Skeletal / Q000187:drug effects* / Q000201:enzymology / Q000473:pathology; D010088:Oxidoreductases / Q000378:metabolism; D010947:Plants, Toxic; D011201:Poultry Diseases / Q000139:chemically induced* / Q000473:pathology; D012639:Seeds; D012676:Senna Extract / Q000633:toxicity*
D012676:Senna Extract; D010088:Oxidoreductases