[Overexpression of P53 and its risk factors in esophageal cancer in urban areas of Xian].
OBJECTIVE
To investigate the risk factors of esophageal cancer (EC) in urban areas of Xi'an, and to correlate these risk factors with overexpression of P53 in EC.


METHODS
A hospital-based case-control study was performed. All cases (89) and controls (97) were permanent residents in urban areas of Xi'an. Tumor tissues and normal tissues adjacent to tumors of 65 cases, and 24 available normal esophageal tissues of controls were detected by P53 overexpression via immunohistochemical method.


RESULTS
Smoking and family history of EC were significantly associated with EC in Xi'an inhabitants. OR was 3.26 and 10.48, respectively. The laboratory findings indicated that P53 positive stain in Ec was 52.3% (34/65) and 6.1% (4/65) in normal tissues adjacent to tumor, but no positive stain was found in normal esophageal tissues of controls. Moreover, the results showed that P53 overexpression was closely related to smoking and family history of EC. OR was 3.89 and 17.28, respectively.


CONCLUSIONS
These findings suggest that smoking and family history of EC are important risk factors for EC, and the alteration of P53 gene may be related to smoking and inherited factor.
Qiao
G
G
Fourth Military Medical University, Xi'an.
Sun
C
C
Wang
Y
Y
D000368:Aged; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D004938:Esophageal Neoplasms / Q000737:chemistry* / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*; D014504:Urban Health
D016159:Tumor Suppressor Protein p53