Vaccine adjuvants.
Vaccine adjuvants provide enhanced immune responses to a variety of antigens. Unlike human vaccines that are limited to aluminum-based adjuvants, veterinary vaccines may contain a large number of substances either alone or in combination that act as vaccine adjuvants. Although the use of adjuvants in veterinary vaccines enhances the immunogenicity of vaccines, they have been responsible for a number of side effects. This article explores the rationale of currently used vaccine adjuvants and some of the adverse events associated with their use in veterinary medicine.
Macy
D W
DW
Department of Clinical Sciences, Colorado State University, College of Veterinary Medicine and Biomedical Sciences, Fort Collins 80523, USA.
D000276:Adjuvants, Immunologic / Q000008:administration & dosage / Q000009:adverse effects / Q000502:physiology*; D000818:Animals; D000941:Antigens / Q000276:immunology; D003692:Delayed-Action Preparations; D007107:Immune System / Q000187:drug effects; D007167:Immunotherapy / Q000379:methods / Q000662:veterinary*; D009369:Neoplasms / Q000139:chemically induced / Q000662:veterinary; D014612:Vaccines / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology*
D000276:Adjuvants, Immunologic; D000941:Antigens; D003692:Delayed-Action Preparations; D014612:Vaccines