DNA repair: caretakers of the genome?.
Recent results show that the 8-oxoguanine DNA repair system is functionally conserved in bacteria and mammals. The bacterial system protects the genome from the mutagenic effects of oxidative stress; the role of the mammalian system is expected to be similar and defects in it may increase susceptibility to cancer.
Cunningham
R P
RP
Department of Biological Sciences, SUNY at Albany, 1400 Washington Avenue, Albany, New York 12222, USA.
D000818:Animals; D004260:DNA Repair; D004926:Escherichia coli / Q000235:genetics; D016680:Genome, Bacterial; D006801:Humans; D008322:Mammals; D016296:Mutagenesis; D018384:Oxidative Stress / Q000235:genetics; D012441:Saccharomyces cerevisiae / Q000235:genetics