TECK: a novel CC chemokine specifically expressed by thymic dendritic cells and potentially involved in T cell development.
A novel CC chemokine was identified in the thymus of mouse and human and was designated TECK (thymus-expressed chemokine). TECK has weak homology to other CC chemokines and maps to mouse chromosome 8. Besides the thymus, mRNA encoding TECK was detected at substantial levels in the small intestine and at low levels in the liver. The source of TECK in the thymus was determined to be thymic dendritic cells; in contrast, bone marrow-derived dendritic cells do not express TECK. The murine TECK recombinant protein showed chemotactic activity for activated macrophages, dendritic cells, and thymocytes. We conclude that TECK represents a novel thymic dendritic cell-specific CC chemokine that is possibly involved in T cell development.
Vicari
A P
AP
DNAX Research Institute, Palo Alto, California 94304-1104, USA.
Figueroa
D J
DJ
Hedrick
J A
JA
Foster
J S
JS
Singh
K P
KP
Menon
S
S
Copeland
N G
NG
Gilbert
D J
DJ
Jenkins
N A
NA
Bacon
K B
KB
Zlotnik
A
A
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002454:Cell Differentiation / Q000276:immunology; D018925:Chemokines / Q000096:biosynthesis* / Q000737:chemistry / Q000235:genetics / Q000502:physiology; D019742:Chemokines, CC; D002634:Chemotaxis, Leukocyte; D002874:Chromosome Mapping; D003001:Cloning, Molecular; D003713:Dendritic Cells / Q000378:metabolism*; D005260:Female; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D008969:Molecular Sequence Data; D009928:Organ Specificity / Q000235:genetics / Q000276:immunology; D012333:RNA, Messenger / Q000096:biosynthesis; D013601:T-Lymphocytes / Q000166:cytology*; D013950:Thymus Gland / Q000166:cytology / Q000378:metabolism*
C108074:CCL25 protein, human; C491541:Ccl25 protein, mouse; D018925:Chemokines; D019742:Chemokines, CC; D012333:RNA, Messenger