title: Optimisation of the reversed phase liquid chromatographic separation of atovaquone, proguanil and related substances.
abstract: The optimisation of the separation of the antimalarial drugs, proguanil and atovaquone and six related compounds was obtained by two independent optimisation steps; the optimisation of the mobile phase composition and the optimisation of the pH. This was done using window selection diagrams (WSD) and a mixture design. The optimal conditions allow the identification of the six related compounds down to 0.1%.
authors.affiliation: Chemo AC, Farmaceutisch Instituut, Vrije Universiteit Brussel, Belgium.
authors.forename: P F
authors.initials: PF
authors.lastname: de Aguiar
authors.forename: Y V
authors.initials: YV
authors.lastname: Vander Heyden
authors.forename: Y
authors.initials: Y
authors.lastname: Van Oost
authors.forename: T J
authors.initials: TJ
authors.lastname: Coomber
authors.forename: D L
authors.initials: DL
authors.lastname: Massart
mesh_terms: D000962:Antimalarials / Q000032:analysis*; D053626:Atovaquone; D002851:Chromatography, High Pressure Liquid; D006863:Hydrogen-Ion Concentration; D009285:Naphthoquinones / Q000032:analysis*; D002727:Proguanil / Q000032:analysis*
chemical_list: D000962:Antimalarials; D009285:Naphthoquinones; D002727:Proguanil; D053626:Atovaquone