A novel method for improving Streptomyces coelicolor A3(2) for production of actinorhodin by introduction of rpsL (encoding ribosomal protein S12) mutations conferring resistance to streptomycin.
Hesketh
A
A
Ochi
K
K
D000880:Anthraquinones / Q000378:metabolism; D000900:Anti-Bacterial Agents / Q000096:biosynthesis*; D004352:Drug Resistance, Microbial; D017354:Point Mutation; D012269:Ribosomal Proteins / Q000235:genetics*; D013302:Streptomyces / Q000235:genetics / Q000378:metabolism*; D013307:Streptomycin / Q000494:pharmacology*; D000095622:Benzoisochromanequinones
D000880:Anthraquinones; D000900:Anti-Bacterial Agents; D012269:Ribosomal Proteins; D013307:Streptomycin; C034212:ribosomal protein S12; C013390:actinorhodin; D000095622:Benzoisochromanequinones