Pain-related behaviour following sodium urate arthritis is expressed in decerebrate chickens.
The role of the telencephalon in pain-related behaviour in arthritis was investigated by measuring pain-coping behaviour (one-legged standing, lameness, sitting) of birds following intra-articular injection of sodium urate crystals. Ten sham-operated and 10 decerebrate birds were injected with sodium urate into the left ankle joint 4 days after surgery, and their behaviour recorded during a 3-h period. Both groups of birds showed pain-coping behaviour, and there was no significant difference between the 2 groups of birds. These results suggest that the behaviours associated with tonic arthritic pain are organised in the brainstem.
Gentle
M J
MJ
Roslin Institute, Edinburgh, Scotland, UK.
D000818:Animals; D001168:Arthritis / Q000139:chemically induced* / Q000503:physiopathology; D001522:Behavior, Animal; D002645:Chickens; D003655:Decerebrate State; D004195:Disease Models, Animal; D010146:Pain / Q000503:physiopathology*; D013687:Telencephalon / Q000502:physiology; D014527:Uric Acid / Q000494:pharmacology
D014527:Uric Acid