Immunobiology of Helicobacter pylori infection.
Helicobacter pylori is a 'slow' bacterial pathogen. While infection is usually acquired early in life, only decades later does severe pathology appear. During this long period of incubation, the host mounts a vigorous immune response against H. pylori which fails to resolve the infection and may in fact contribute to the severity of the disease. In the past year, evidence has accumulated indicating a role for a polarized T helper 1 cell response in the gastric pathology induced by H. pylori. Furthermore, a pathogenicity island in type I H. pylori strains has been shown to be responsible for H. pylori induced inflammation. Recent advances in animal models have provided the rationale for entering into human clinical trials of an H. pylori vaccine
Telford
J L
JL
Department of Molecular Biology, Chiron Vaccines, Immunobiological Research Institute, Siena Via Fiorentina 1, 53100, Siena, Italy. telford@iris02.biocine.it
Covacci
A
A
Rappuoli
R
R
Chiara
P
P
D000230:Adenocarcinoma / Q000209:etiology / Q000382:microbiology; D000818:Animals; D001284:Atrophy; D001327:Autoimmune Diseases / Q000209:etiology / Q000276:immunology / Q000382:microbiology; D001426:Bacterial Proteins / Q000235:genetics / Q000502:physiology; D005753:Gastric Mucosa / Q000382:microbiology / Q000473:pathology; D005756:Gastritis / Q000150:complications / Q000276:immunology* / Q000382:microbiology; D016481:Helicobacter Infections / Q000150:complications / Q000276:immunology*; D016480:Helicobacter pylori / Q000235:genetics / Q000276:immunology* / Q000472:pathogenicity; D006801:Humans; D018442:Lymphoma, B-Cell, Marginal Zone / Q000209:etiology / Q000276:immunology / Q000382:microbiology; D051379:Mice; D018716:Molecular Mimicry; D011230:Precancerous Conditions / Q000382:microbiology; D013274:Stomach Neoplasms / Q000209:etiology / Q000382:microbiology
D001426:Bacterial Proteins; C074689:VacA protein, Helicobacter pylori