[Cytomegalovirus disease after hematopoietic recovery in a patient with non-Hodgkin's lymphoma].
We report a case of marked cytomegalovirus (CMV)-antigenemia determined by direct immunoperoxidase staining using a peroxidase-labeled monoclonal antibody HRP-C7, after conventional chemotherapy for malignant lymphoma. A 65-year-old Japanese man suffered from unexplained fever, mild liver dysfunction and an abnormal shadow in the lung after hematopoietic recovery from intensive chemotherapy for T-cell non-Hodgkin's lymphoma in the leukemic phase. The assay for CMV-antigenemia revealed that he had an active CMV infection. After treatment with ganciclovir and gamma-globulin, his symptoms and signs improved with the decrease of CMV antigen-positive leukocytes. CMV disease should be considered in these situations, and the CMV antigen-detection assay is useful for rapid diagnosis of CMV infection.
Kondo
T
T
First Department of Internal Medicine, Faculty of Medicine, Kyushu University.
Fujisaki
T
T
Gondo
H
H
Otsuka
T
T
Takenaka
K
K
Tanimoto
K
K
Niho
Y
Y
D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003586:Cytomegalovirus Infections / Q000175:diagnosis* / Q000209:etiology*; D006410:Hematopoiesis; D006801:Humans; D016399:Lymphoma, T-Cell / Q000188:drug therapy*; D008297:Male