title: Drinking water chlorination by-products and cancer.
abstract: This review discusses the relation between by-products of drinking water chlorination and cancer in the light of present toxicological and epidemiologic evidence. During the chlorination of drinking water, a complex mixture of by-products forms from chlorine and the organic and inorganic compounds present in raw water. The quality and quantity of such compounds depend on the specific nature of the organic material in raw waters, the inorganic material in raw water, pH, temperature, other water treatment practices, and the chlorine timing and dose added. Chlorination by-products are important mainly when surface water is used for drinking water as more organic compounds are present in surface waters than in ground waters. The gastrointestinal and urinary tract are the cancer sites that are most often associated with the use of chlorinated surface water or with the quantity of chlorination by-products in the water-supply network. Yet the microbial quality of drinking water should not be compromised by excessive caution over the potential long-term effects of disinfection by-products because the risk of illness and death resulting from exposure to pathogens in untreated drinking water may be several orders of magnitude greater than the cancer risks from chlorination by-products.
authors.affiliation: Finnish Cancer Registry, Helsinki, Finland. meri.koivusalo@cancer.fi
authors.forename: M
authors.initials: M
authors.lastname: Koivusalo
authors.forename: T
authors.initials: T
authors.lastname: Vartiainen
mesh_terms: D002273:Carcinogens; D016022:Case-Control Studies; D002713:Chlorine / Q000009:adverse effects* / Q000737:chemistry; D004782:Environmental Health; D006219:Halogens / Q000009:adverse effects; D006801:Humans; D009369:Neoplasms / Q000139:chemically induced*; D014876:Water Pollution; D018508:Water Purification
chemical_list: D002273:Carcinogens; D006219:Halogens; D002713:Chlorine