[The role of urokinase type plasminogen activator in invasion of bile duct carcinoma].
OBJECTIVE
To study the role of urokinase type plasminogen activator (u-PA) in the invasive process of bile duct carcinoma.


METHODS
The secretion of u-PA and the invasive potential of tumor cell in vitro in a newly established cell line of bile duct carcinoma, QBC939, were observed by using an amnion invasion culture system.


RESULTS
QBC939 cells secreted u-PA with high invasive potential. The inhibitors of u-PA and plasmin, tranexamic acid and 6-aminocaproic acid, obviously inhibited the u-PA activity and the invasive potential of QBC939 cells.


CONCLUSIONS
u-PA is one of the important enzymes in tumor invasion. Inhibiting u-PA or plasmin may be a prospective therapy for tumor treatment.
Wang
S
S
Center of Hepatobiliary Surgery, Southwest Hospital, Chongqing.
Han
B
B
Duan
H
H
D001650:Bile Duct Neoplasms / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D014407:Tumor Cells, Cultured; D014568:Urokinase-Type Plasminogen Activator / Q000502:physiology*
D014568:Urokinase-Type Plasminogen Activator