The molecular physiology of electroneutral cation-chloride cotransport.
The application of molecular biology to the study of electroneutral cation-chloride cotransporters has been extremely successful, resulting in the identification of a new gene family of five membrane proteins. The function, expression, and regulation of these important proteins can increasingly be described in molecular terms. In addition, mutations in two renal cation-chloride transporter genes have been found in patients with Bartter's and Gitelman's syndromes, autosomal recessive disorders of renal salt excretion.
Mount
D B
DB
Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232-2372, USA.
Hoover
R S
RS
Hebert
S C
SC
D000818:Animals; D001477:Bartter Syndrome; D001483:Base Sequence; D001692:Biological Transport; D002352:Carrier Proteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D002412:Cations; D002712:Chlorides / Q000378:metabolism*; D004247:DNA; D004563:Electrochemistry; D006801:Humans; D008969:Molecular Sequence Data; D028021:Sodium-Potassium-Chloride Symporters
D002352:Carrier Proteins; D002412:Cations; D002712:Chlorides; D028021:Sodium-Potassium-Chloride Symporters; D004247:DNA