title: Clinicopathological profile of subacute hepatic failure.
abstract: Twenty two patients of subacute hepatic failure (SAHF), diagnosed when jaundice progressed for more than 8 weeks with appearance of ascites, with or without encephalopathy, along with biochemical evidence of hepatocellular damage, were studied. The male and female ratio was 4.5:1 and majority (45.4%) of cases were between the age group of 41-50. The mean biochemical values were: S.bilirubin; 9.2 +/- 3.8 mg/dl SGOT; 94.4 +/- 25.0 I.U./lit., SGPT; 107.8 +/- 32.7 I.U./lit., S.Protein; 5.2 +/- 3.5 secs. Ascitic fluid analysis showed transudate in 16 (72.7%) and exudate in 6 (27.2%) patients. Bacterial peritonitis was found in 5 (22.7%) patients. Liver biopsy showed bridging and submassive necrosis. The complications developed in the hospital were: renal failure (36.3%), infection (27.2%), G.I. bleeding (18.1%) and encephalopathy (13.6%). The mortality was (86.3%). Out of 3 (13.6%) patients who survived, only two recovered completely and one had biochemical evidence of hepatocellular necrosis after 6 months of follow up.
authors.affiliation: M.K.C.G. Medical College, Berhampur, Ganjam, Orissa.
authors.forename: M K
authors.initials: MK
authors.lastname: Mohapatra
authors.forename: M M
authors.initials: MM
authors.lastname: Samal
authors.forename: K N
authors.initials: KN
authors.lastname: Padhiary
authors.forename: P C
authors.initials: PC
authors.lastname: Dash
authors.forename: G N
authors.initials: GN
authors.lastname: Sahoo
authors.forename: B C
authors.initials: BC
authors.lastname: Patnaik
mesh_terms: D000208:Acute Disease; D000328:Adult; D001201:Ascites / Q000209:etiology; D001706:Biopsy; D003937:Diagnosis, Differential; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006501:Hepatic Encephalopathy / Q000209:etiology; D006801:Humans; D007565:Jaundice / Q000209:etiology; D008099:Liver / Q000473:pathology*; D017093:Liver Failure / Q000150:complications / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D015996:Survival Rate