title: [Symptomatic therapy of severe diarrhea in eosinophilic gastroenteritis with the somatostatin analog octreotide (Sandostatin)].
abstract: We describe a patient with eosinophilic gastroenteritis whose symptoms included severe watery diarrhea (1.5 l/d), abdominal cramps, and weight loss. Biopsies revealed massive eosinophilic inflammation of the entire gastrointestinal tract. The total plasma eosinophilic count was elevated by up to 30%. Infectious etiologies and chronic inflammatory bowel disease had been ruled out. By use of the somatostatin analogue octreotide the diarrhea decreased immediately in a dose-dependent fashion and the patient recovered within twelve days. In this case octreotide was helpful in controlling severe diarrhea and limiting the subsequent necessary i.v. fluid replacement.
authors.affiliation: Abteilung für Gastroenterologie, Kantonsspital Liestal.
authors.forename: T
authors.initials: T
authors.lastname: Rausch
authors.forename: K
authors.initials: K
authors.lastname: Gyr
authors.forename: W
authors.initials: W
authors.lastname: Wegmann
authors.forename: M
authors.initials: M
authors.lastname: Germer
authors.forename: R
authors.initials: R
authors.lastname: Meier
mesh_terms: D000328:Adult; D001706:Biopsy; D004064:Digestive System / Q000473:pathology; D004305:Dose-Response Relationship, Drug; D004802:Eosinophilia / Q000188:drug therapy* / Q000473:pathology; D005759:Gastroenteritis / Q000188:drug therapy* / Q000473:pathology; D005765:Gastrointestinal Agents / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D015282:Octreotide / Q000627:therapeutic use*
chemical_list: D005765:Gastrointestinal Agents; D015282:Octreotide