Toxicological correlation between changes in blood biochemical parameters and liver histopathological findings.
The toxicological correlation between blood biochemical parameters and liver histopathological findings was summarized mainly in rats and dogs on the basis of our experiments and published papers. In rats and dogs with hepatocytic necrosis, GPT and GOT increased with a good correlation to necrotic severity. In dogs with cholestasis, ALP, gamma-GTP, T.BIL and BSP retention rates increased. In mixed types of hepatitis or cholestasis and hepatic necrosis, GPT, GOT and ALP increased in rats and dogs and additionally gamma-GTP and BSP retention rates increased in dogs. In hepatic steatosis, CHOL and TRIG decreased in rats and dogs. In hepatic injury due to accumulation of foreign materials or cell components and sinusoidal cell injury, no specific correlation with biochemical parameters was noted.
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Toxicology Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., Osaka, Japan.
D000208:Acute Disease; D000410:Alanine Transaminase / Q000097:blood*; D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood*; D001663:Bilirubin / Q000097:blood; D002779:Cholestasis / Q000139:chemically induced / Q000473:pathology; D004285:Dogs; D064420:Drug-Related Side Effects and Adverse Reactions / Q000097:blood*; D007728:Kupffer Cells / Q000187:drug effects / Q000473:pathology; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008099:Liver / Q000187:drug effects / Q000473:pathology*; D009336:Necrosis; D051381:Rats; D012795:Sialoglycoproteins / Q000097:blood; D005723:gamma-Glutamyltransferase / Q000097:blood
D012795:Sialoglycoproteins; D007770:L-Lactate Dehydrogenase; D005723:gamma-Glutamyltransferase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase; D001663:Bilirubin