Intrathecal production of measles-specific IgA in subacute sclerosing panencephalitis.
OBJECTIVE
We measured measles-specific IgA in matched pairs of cerebrospinal fluid (CSF) and sera of patients with subacute sclerosing panencephalitis (SSPE), multiple sclerosis (MS), other central nervous system (CNS) infectious diseases (INF) and other neurological diseases (OND) by using enzyme linked immunosorbent assay.


METHODS
CSF and sera from 23 patients with SSPE, 15 with MS, 14 with INF, and 15 with OND were included in the study.


RESULTS
The ratios of measles-specific IgA in CSF to serum were increased in SSPE patients compared to patients with MS, INF or OND.


CONCLUSIONS
The data indicate a local production of measles-specific IgA in the CNS of SSPE patients.
Visudtibhan
A
A
Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314-6399, USA.
Mehta
P D
PD
Kulczycki
J
J
Coyle
P K
PK
Thormar
H
H
D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D000914:Antibodies, Viral / Q000097:blood / Q000134:cerebrospinal fluid*; D016022:Case-Control Studies; D002648:Child; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood / Q000134:cerebrospinal fluid*; D016555:Matched-Pair Analysis; D008459:Measles virus / Q000276:immunology*; D009103:Multiple Sclerosis / Q000097:blood / Q000134:cerebrospinal fluid / Q000276:immunology; D009422:Nervous System Diseases / Q000097:blood / Q000134:cerebrospinal fluid / Q000276:immunology; D013344:Subacute Sclerosing Panencephalitis / Q000097:blood / Q000134:cerebrospinal fluid / Q000276:immunology*
D000914:Antibodies, Viral; D007070:Immunoglobulin A