Positive association between the GABRA5 gene and unipolar recurrent major depression.
The gamma-aminobutyric acid (GABA) neurotransmitter system has been implicated in the pathogenesis of mood disorders. To test this hypothesis we carried out an association study between a dinucleotide repeat polymorphism in the GABAA receptor alpha 5 subunit gene and bipolar and unipolar mood disorders. Our results suggest a possible involvement of this gene in unipolar but not in bipolar disorder.
Oruc
L
L
Flanders Interuniversity Institute for Biotechnology, Born-Bunge Foundation, Department of Biochemistry, University of Antwerp, Belgium.
Verheyen
G R
GR
Furac
I
I
Ivezić
S
S
Jakovljević
M
M
Raeymaekers
P
P
Van Broeckhoven
C
C
D000328:Adult; D000368:Aged; D001714:Bipolar Disorder / Q000235:genetics; D004247:DNA / Q000032:analysis; D003866:Depressive Disorder / Q000235:genetics*; D005260:Female; D008040:Genetic Linkage; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D011963:Receptors, GABA-A / Q000235:genetics*; D012008:Recurrence
D011963:Receptors, GABA-A; D004247:DNA