[Natural products from the tropical rain forest of Venezuela as inhibitors of HIV-1 replication].
More than 100 plant extracts from the Amazonian rain forest of Venezuela were evaluated for their cytotoxicity and inhibitory activity against the human immunodeficiency virus type-1 (HIV-1). Aqueous extracts from Fomitella supina (S # 0389-4), Phellinus rhabarbarinus (S # 0389-7), Trichaptum perrottetti (S # 0389-8) and Trametes cubensis (S # 0389-13), Polyporaceae exhibited strong anti-HIV-1 activity, without toxicity for Molt-4 lymphocytic cells. Our results demonstrated, that the compound(s) acted by mechanism of direct virion inactivation and by inhibition of syncytium formation in an in vitro culture system. These results support the suggestion that the test extracts specifically act at the level of CD4-gp120 binding. The active components of these extracts is at present unknown, but anti-AIDS agents, such as those found in this study, individually or in combination, may be of therapeutic relevance.
Walder
R
R
Instituto Venezolano de Investigaciones Científicas (I.V.I.C.), Centro de Microbiología y Biología Celular, Caracas, Venezuela.
Kalvatchev
Z
Z
Garzaro
D
D
Barrios
M
M
D000998:Antiviral Agents / Q000494:pharmacology*; D002459:Cell Fusion; D015497:HIV-1 / Q000502:physiology*; D006801:Humans; D010936:Plant Extracts / Q000494:pharmacology*; D014687:Venezuela; D014779:Virus Replication / Q000187:drug effects*
D000998:Antiviral Agents; D010936:Plant Extracts