Strain differences in pentylenetetrazol-kindling development and subsequent potentiation effects.
Rats from two different strains, i.e. Wistar rats and Lister hooded rats, were investigated for their ability to acquire the kindling syndrome. After having received 13 kindling stimulations (injection of pentylenetetrazol), the animals were tested for subsequent alterations in induction and maintenance of hippocampal long-term potentiation (LTP) and, moreover in glutamate binding. It was found that rats from both strains did not differ in the response to the initial injection of pentylenetetrazol (PTZ) and the amplitude of the population spike. This suggests that some aspects of basic central excitability are equivalent. Wistar rats acquired the kindling syndrome rapidly whereas seizure outcome was poor in Lister rats. As regards hippocampal LTP, the population spike was only dramatically increased in Wistar rats after kindling completion. Glutamate binding was not altered in animals from the Lister strain. The results suggest that changes in glutamate binding and the increase in the population spike are characteristic consequences of kindling.
Becker
A
A
Otto-von-Guericke University, Faculty of Medicine, Institute of Pharmacology and Toxicology, Magdeburg, Germany. axel.becker@medizin.uni.magdeburg.de
Krug
M
M
Schröder
H
H
D000818:Animals; D003292:Convulsants / Q000494:pharmacology; D004195:Disease Models, Animal; D004827:Epilepsy / Q000139:chemically induced*; D018698:Glutamic Acid / Q000378:metabolism; D007696:Kindling, Neurologic; D008297:Male; D010433:Pentylenetetrazole / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar
D003292:Convulsants; D018698:Glutamic Acid; D010433:Pentylenetetrazole