Sexually dimorphic effects of anti-NGF treatment in neonatal rats.
This study investigated how chronic perinatal reduction of nerve growth factor (NGF) affected brain cholinergic markers in the two sexes. Rats received anti-NGF on postnatal days (PNDs) 2-12, and choline acetyltransferase (ChAT) activity was measured on PND 16. Anti-NGF significantly reduced cortical ChAT activity in males, but not in females; no sex-dependent effects were found in hippocampus or striatum. These data suggest sexual dimorphism in cholinergic responsiveness to NGF.
Ricceri
L
L
Section of Comparative Psychology, Istituto Superiore di Sanità, Rome, Italy.
Ewusi
A
A
Calamandrei
G
G
Berger-Sweeney
J
J
D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D001921:Brain / Q000201:enzymology / Q000254:growth & development*; D001923:Brain Chemistry / Q000502:physiology; D002540:Cerebral Cortex / Q000201:enzymology / Q000254:growth & development / Q000378:metabolism; D002795:Choline O-Acetyltransferase / Q000378:metabolism; D005260:Female; D006624:Hippocampus / Q000201:enzymology / Q000254:growth & development / Q000378:metabolism; D008297:Male; D017072:Neostriatum / Q000201:enzymology / Q000254:growth & development / Q000378:metabolism; D009414:Nerve Growth Factors / Q000502:physiology*; D010275:Parasympathetic Nervous System / Q000187:drug effects / Q000254:growth & development; D051381:Rats; D017208:Rats, Wistar; D012727:Sex Characteristics
D009414:Nerve Growth Factors; D002795:Choline O-Acetyltransferase