Systemic liberation of interleukin-8 in the perioperative phase of liver transplantation.
Serum levels of interleukin-8 (IL-8) were investigated in the perioperative phase of liver transplantation (LTx) in order to help determine whether this cytokine might serve as a parameter for preservation injury. In a study of 45 patients undergoing LTx, systemic IL-8 was estimated at the end of the anhepatic phase, at 30, 60, and 120 min after reperfusion of the graft, and 24 h and 7 days after LTx. A maximum mean concentration of 665 +/- 135 pg/ml was seen 60 min after LTx. The minimum was found on the 1st postoperative day (POD 1): 328 +/- 33 pg/ml. Significant changes were found between 60 min and PODs 1 and 7, as well as between 120 min and POD 1. Differences in cold ischemia time were not found to be significant. We conclude that monitoring of systemic IL-8 levels is not useful in the development of new liver preservation concepts.
Gerlach
J
J
Department of Surgery, Rudolf Virchow Clinic, Humboldt University Berlin, Germany.
Jörres
A
A
Schön
M
M
Nohr
R
R
Berger
A
A
Spatkowski
G
G
Smith
M D
MD
Neuhaus
P
P
D000328:Adult; D016572:Cyclosporine / Q000627:therapeutic use; D005260:Female; D006086:Graft vs Host Disease / Q000517:prevention & control; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D016209:Interleukin-8 / Q000097:blood*; D008099:Liver / Q000601:surgery; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D016559:Tacrolimus / Q000627:therapeutic use
D007166:Immunosuppressive Agents; D016209:Interleukin-8; D016572:Cyclosporine; D016559:Tacrolimus