title: [Leishmania (Viannia) braziliensis Vianna, 1911 in French Guiana. Clinical, therapeutic and epidemiological considerations in the ninth human diagnosed case].
abstract: The authors report the ninth case of cutaneous Leishmaniasis without mucosal involvement due to Leishmania (Viannia) braziliensis (isoenzymatic profile related to zymodeme MON-44) diagnosed in a legionnaire who recently arrived in French Guiana. The skin lesion as a single ulcerated nodule of the dorsum of the left ringfinger was cured after two courses of four intramuscular injections of pentamidine isothionate (total posology of pentamidine-base: 16.6 mg/kg). The transmission occurred during nocturnal trekking in forest and swamps just behind the coastal belt at Degrad Saramaka (7 km South of Kourou). In French Guiana, the good level of medical care and the early treatment of the majority of the cases of Leishmaniasis may explain the rarity of mucosal lesions. Since the clinical aspect of the lesion is not sufficient to prejudge the identity of the causative species, it is necessary to perform cultivation of Leishmania for iso-enzymatic identification. The adaptation of pentamidine doses and long term follow up of patients infected by L. (V.) braziliensis could be defined more precisely.
authors.affiliation: Laboratoire de biologie polyvalerite, l'université des Antilles, Cayenne.
authors.forename: C P
authors.initials: CP
authors.lastname: Raccurt
authors.forename: R
authors.initials: R
authors.lastname: Pradinaud
authors.forename: P
authors.initials: P
authors.lastname: Couppie
authors.forename: B
authors.initials: B
authors.lastname: Moreau
authors.forename: F
authors.initials: F
authors.lastname: Pratlong
authors.forename: J P
authors.initials: JP
authors.lastname: Dedet
authors.forename: P
authors.initials: P
authors.lastname: Cotellon
authors.forename: B
authors.initials: B
authors.lastname: Juminer
authors.forename: D
authors.initials: D
authors.lastname: Sainte-Marie
mesh_terms: D000328:Adult; D000818:Animals; D000981:Antiprotozoal Agents / Q000627:therapeutic use; D005616:French Guiana / Q000453:epidemiology; D006801:Humans; D007892:Leishmania braziliensis; D016773:Leishmaniasis, Cutaneous / Q000188:drug therapy / Q000453:epidemiology / Q000469:parasitology*; D008297:Male; D008889:Military Personnel; D010419:Pentamidine / Q000627:therapeutic use; D014197:Trees
chemical_list: D000981:Antiprotozoal Agents; D010419:Pentamidine