title: Increased plasma levels of soluble CD23 in haemorrhagic fever with renal syndrome; relation to virus-specific IgE.
abstract: In 15 consecutive patients hospitalized with nephropathia epidemica, a European form of haemorrhagic fever with renal syndrome (HFRS) caused by Puumala virus, plasma concentrations of soluble CD23 (sCD23) and Puumala virus-specific IgE were determined. In the acute phase of illness, 11/15 patients had increased sCD23 levels (> 91 U/ml), whereas in convalescence, values of 8/10 patients were normalized. Maximal sCD23 values were correlated to maximal concentrations of Puumala virus-specific serum IgE (r = 0.597; P = 0.025). The results are compatible with a known ability of sCD23 to augment IgE production.
authors.affiliation: Department of Virology, Umeå University, Sweden.
authors.forename: O A
authors.initials: OA
authors.lastname: Alexeyev
authors.forename: M
authors.initials: M
authors.lastname: Linderholm
authors.forename: F
authors.initials: F
authors.lastname: Elgh
authors.forename: G
authors.initials: G
authors.lastname: Wadell
authors.forename: P
authors.initials: P
authors.lastname: Juto
authors.forename: A
authors.initials: A
authors.lastname: Tärnvik
mesh_terms: D000328:Adult; D000368:Aged; D000914:Antibodies, Viral / Q000378:metabolism*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006476:Orthohantavirus / Q000276:immunology*; D006480:Hemorrhagic Fever with Renal Syndrome / Q000097:blood* / Q000503:physiopathology / Q000821:virology; D006801:Humans; D007073:Immunoglobulin E / Q000378:metabolism*; D018793:Interleukin-13 / Q000097:blood; D007668:Kidney / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D017455:Receptors, IgE / Q000097:blood*
chemical_list: D000914:Antibodies, Viral; D018793:Interleukin-13; D017455:Receptors, IgE; D007073:Immunoglobulin E