[Interaction of a substance based on phytoecdysteroids (BTK-8L) with components of fractionated chromatin from intact rat liver].
Results of the study of interaction of the phytoecdysteroid preparation (BTK-8L) with fractionated rat liver nuclear chromatin were described. It was shown that the interaction resulted in the "loosening" of the histone proteins structure both in active and repressed chromatin. At the same time the reparative DNA synthesis in the repressed fraction was stimulated. The Change revealed might be the basis of protective properties of BTK-8L as to chromatin at chloro and organophosphorus intoxications.
Primak
R G
RG
Levitskiĭ
E L
EL
Gubskiĭ
Iu I
IuI
Goriushko
A G
AG
Kholodova
Iu D
IuD
Vistunova
I E
IE
D000818:Animals; D002843:Chromatin / Q000378:metabolism*; D004247:DNA / Q000187:drug effects; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D009690:Nucleic Acid Conformation; D011487:Protein Conformation; D051381:Rats; D017208:Rats, Wistar; D013256:Steroids / Q000494:pharmacology*
C088577:BTK 8L preparation; D002843:Chromatin; D013256:Steroids; D004247:DNA