Relationship between some humoral factors and left ventricular hypertrophy in essential hypertension.
OBJECTIVE
To evaluate the relationship between certain humoral factors and left ventricular hypertrophy (LVH) in essential hypertension.


METHODS
62 essential hypertension (EH) patients (32 men, 30 women; mean age, 55 years) and 20 normotensive healthy subjects (10 men, 10 women: mean age, 52 years) were studied. EH patients were divided into LVH group and non-LVH group by echocardiography. After an overnight fast, blood samples were taken for the determination of parathyroid hormone (PTH), angiotensin II (ATII) and aldosterone (ALD) by radioimmunoassay.


RESULTS
There was a significant difference in PTH. AT II and ALD between the EH group and control group. Furthermore, in LVH group PTH, ATII and ALD elevated significantly as compared with non-LVH group. In addition, we found that LVMI (left ventricular mass index) correlated with ATII (r = 0.342, P < 0.01) and ALD (r = 0.356, P < 0.01). There was a more significant correlation between LVMI and PTH (r = 0.422, P < 0.0025).


CONCLUSIONS
Some humoral factors are important determinants of LV mass. Besides the reninangiotensin-aldosterone system, PTH might play an important role in cardiac hypertrophy.
Hui
Y
Y
Department of Cardiovascular Medicine, Electric Power General Hospital, Beijing.
Hao
Y
Y
Chen
X
X
Jing
S
S
Dai
Z
Z
D000450:Aldosterone / Q000097:blood; D000804:Angiotensin II / Q000097:blood; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000150:complications; D017379:Hypertrophy, Left Ventricular / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood*; D012084:Renin-Angiotensin System
D010281:Parathyroid Hormone; D000804:Angiotensin II; D000450:Aldosterone