[Importance of toxicological studies in animals for elaboration of pathogenetic therapy of hydrazine intoxication].
Pathogenesis of poisoning with hydrazine seems complicated. Hydrazines inhibit pyridoxal-dependent enzymes, interfere with carbohydrates transformation and lipid metabolism, alter the processes of energy metabolism. Treatment of poisoning with hydrazine is effective only when containing drug combinations. Based experimentally, recommendations on the combination (phenazepam, be methyl, piracetam, ionol) were supported by chemical testing of the drugs.
Baryshnikov
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D000276:Adjuvants, Immunologic / Q000008:administration & dosage*; D000818:Animals; D014151:Anti-Anxiety Agents; D000975:Antioxidants / Q000008:administration & dosage*; D001562:Benzimidazoles / Q000008:administration & dosage*; D001569:Benzodiazepines; D001570:Benzodiazepinones / Q000008:administration & dosage*; D002084:Butylated Hydroxytoluene / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D006830:Hydralazine / Q000506:poisoning*; D018697:Nootropic Agents / Q000008:administration & dosage*; D010889:Piracetam / Q000008:administration & dosage*; D011041:Poisoning / Q000188:drug therapy / Q000378:metabolism; D051381:Rats
D000276:Adjuvants, Immunologic; D014151:Anti-Anxiety Agents; D000975:Antioxidants; D001562:Benzimidazoles; D001570:Benzodiazepinones; D018697:Nootropic Agents; D001569:Benzodiazepines; D002084:Butylated Hydroxytoluene; D006830:Hydralazine; C017928:phenazepam; C049825:bemethyl; D010889:Piracetam