Functional recovery of retina after sodium iodate injection in mice.
ERGs and the azide responses were recorded from mice before and periodically up to 6 weeks after retinal pigment epithelium (RPE) damage by iodate injection to follow the recovery of retinal pigment epithelium and retinal function. At 14 days postinjection, there was a partial recovery of the maximal b-wave amplitude and the azide response but no further recovery was found after 14 days. The retinal sensitivity showed a slow recovery, and at 6 weeks postinjection did not differ from the pre-iodate sensitivity. These findings correlated with histological observations. We concluded that the recovery in ERGs resulted from RPE recovery and the large patchy area of recovered retina functioned normally.
Mizota
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A
Department of Ophthalmology, Chiba University School of Medicine, Japan.
Adachi-Usami
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E
D000818:Animals; D001386:Azides / Q000494:pharmacology; D003864:Depression, Chemical; D004596:Electroretinography; D007452:Iodates / Q000633:toxicity*; D051379:Mice; D008807:Mice, Inbred BALB C; D010857:Pigment Epithelium of Eye / Q000187:drug effects / Q000473:pathology; D012160:Retina / Q000187:drug effects* / Q000473:pathology / Q000502:physiology; D019810:Sodium Azide; D013997:Time Factors
D001386:Azides; D007452:Iodates; D019810:Sodium Azide; C032285:sodium iodate