Angiotropic lymphoma with endocrine involvement.
OBJECTIVE
Two cases of angiotropic high-grade B-cell lymphoma are described in which involvement of endocrine glands was a prominent feature.


RESULTS
One patient had marked unilateral adrenomegally due to lymphoma within adrenal blood vessels. He is alive 5 years after presentation following combination chemotherapy. The diagnosis was made at autopsy in the second patient who presented with pyrexia of unknown origin and had hypothyroidism and a thyroid nodule. The thyroid gland and pituitary showed striking involvement by angiotropic lymphoma and the thyroid nodule was a cavernous haemangioma heavily colonized by lymphoma cells.


CONCLUSIONS
Our cases illustrate endocrine organ manifestations of this rare disease. The condition may respond to combination chemotherapy.
Shanks
J H
JH
Department of Histopathology, Christie Hospital, Manchester, UK.
Harris
M
M
Howat
A J
AJ
Freemont
A J
AJ
D000310:Adrenal Gland Neoplasms / Q000473:pathology* / Q000503:physiopathology; D000368:Aged; D001808:Blood Vessels / Q000473:pathology*; D005260:Female; D006801:Humans; D008223:Lymphoma / Q000473:pathology* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D013964:Thyroid Neoplasms / Q000473:pathology* / Q000503:physiopathology