The use of growth factors to increase glomerular filtration rate in chronic renal failure patients.
Insulin-like growth factor-1 has been safely administered to humans with chronic renal failure in an attempt to increase glomerular filtration rate. The results of short-term studies have been encouraging. Further studies will be required to better define the role of this or other growth factors in increasing glomerular filtration rate in patients with chronic renal failure.
Miller
S B
SB
Division of Nephrology, Washington University School of Medicine, St. Louis, MO 63110, USA. smiller@imgate.wustl.edu
Rabkin
R
R
D005919:Glomerular Filtration Rate / Q000187:drug effects*; D006133:Growth Substances / Q000627:therapeutic use*; D019382:Human Growth Hormone / Q000627:therapeutic use; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D007676:Kidney Failure, Chronic / Q000188:drug therapy* / Q000503:physiopathology*
D006133:Growth Substances; D019382:Human Growth Hormone; D007334:Insulin-Like Growth Factor I