title: Controlled study of psychiatric comorbidity in psychiatrically hospitalized young adults with substance use disorders.
abstract: OBJECTIVE
  The purpose of this study was to examine DSM-III-R axis I and axis II comorbidity in psychiatrically hospitalized young adults with substance use disorders.
  
  
  METHODS
  Structured diagnostic interviews were given to 117 consecutive inpatients. Seventy patients with substance use disorders and 47 patients without substance use disorders were compared.
  
  
  RESULTS
  High rates of co-occurrence of axis I disorders were observed, but no disorder coexisted in the group with substance use disorders at a significantly higher rate than in the group without substance use disorders. Among axis II disorders, borderline personality disorder was diagnosed significantly more frequently in the group with substance use disorders.
  
  
  CONCLUSIONS
  Significant additional diagnostic co-occurrence, defined as comorbidity, was observed only between borderline personality disorder and substance use disorders. The use of a relevant psychiatric comparison group allows for finer distinctions between covariation based on shared severity and comorbidity possibly based on shared pathophysiology.
authors.affiliation: Yale Psychiatric Institute, Yale University School of Medicine, New Heaven, CT 06520, USA.
authors.forename: C M
authors.initials: CM
authors.lastname: Grilo
authors.forename: S
authors.initials: S
authors.lastname: Martino
authors.forename: M L
authors.initials: ML
authors.lastname: Walker
authors.forename: D F
authors.initials: DF
authors.lastname: Becker
authors.forename: W S
authors.initials: WS
authors.lastname: Edell
authors.forename: T H
authors.initials: TH
authors.lastname: McGlashan
mesh_terms: D000293:Adolescent; D000328:Adult; D001883:Borderline Personality Disorder / Q000175:diagnosis / Q000453:epidemiology; D015897:Comorbidity; D003430:Cross-Sectional Studies; D005260:Female; D006760:Hospitalization; D006778:Hospitals, Psychiatric; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000175:diagnosis / Q000453:epidemiology*; D010554:Personality Disorders / Q000175:diagnosis / Q000453:epidemiology; D011569:Psychiatric Status Rating Scales / Q000706:statistics & numerical data; D012720:Severity of Illness Index; D019966:Substance-Related Disorders / Q000175:diagnosis / Q000453:epidemiology*