Valproate inhibits the mitochondrial pyruvate-driven oxidative phosphorylation in vitro.
Silva
M F
MF
C.M.G., Faculdade de Farmácia, Universidade de Lisboa, Portugal.
Ruiter
J P
JP
Illst
L
L
Jakobs
C
C
Duran
M
M
de Almeida
I T
IT
Wanders
R J
RJ
D000255:Adenosine Triphosphate / Q000096:biosynthesis; D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D004072:Digitonin / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism*; D010085:Oxidative Phosphorylation / Q000187:drug effects*; D010101:Oxygen Consumption / Q000187:drug effects; D011048:Polarography; D011773:Pyruvates / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D014635:Valproic Acid / Q000494:pharmacology*
D000927:Anticonvulsants; D011773:Pyruvates; D014635:Valproic Acid; D000255:Adenosine Triphosphate; D004072:Digitonin