Cross-reaction patterns in patients with contact allergy to simple methylol phenols.
The low-molecular-weight phenols 2-methylol phenol (2-MP), 4-methylol phenol (4-MP), 2,4,6-trimethylol phenol (2,4,6-MP), 3-methylol phenol (3-MP), 2,4-dimethylol phenol (2,4-MP), and 2,6-dimethylol phenol (2,6-MP) are contact sensitizers in resins based on phenol and formaldehyde (P-F-R). Other chemically related low-molecular-weight phenols are common in the environment. In patients hypersensitive to P-F-R and MPs, it is for diagnostic, therapeutic and preventive reasons necessary to know their cross-reaction patterns, which this study was therefore designed to investigate. In patients with contact allergy to a P-F-R and at least 1 MP, additional patch testing was performed with 6 MPs and 13 chemically related compounds. The 19 substances were tested at equimolar concentrations and in serial dilutions. Investigations by high-performance liquid chromatography were carried out to exclude contamination as the cause of the patch test reactions. Probable cross-reacting substances were o-cresol, p-cresol, salicylaldehyde, 2,4-dimethyl phenol, and 2,6-dimethyl phenol.
Bruze
M
M
Department of Occupational and Environmental Dermatology, University Hospital, Malmö, Sweden.
Zimerson
E
E
D000485:Allergens / Q000276:immunology*; D001592:Benzyl Alcohols / Q000737:chemistry / Q000276:immunology*; D002851:Chromatography, High Pressure Liquid; D003429:Cross Reactions; D017449:Dermatitis, Allergic Contact / Q000209:etiology / Q000276:immunology*; D006801:Humans; D015394:Molecular Structure; D010328:Patch Tests
D000485:Allergens; D001592:Benzyl Alcohols