Targeted delivery of peptides, proteins, and genes by receptor-mediated endocytosis.
Receptor-mediated endocytosis (RME) is one type of delivery system by which therapeutic agents can be specifically transported to their target. Although many successful studies have been performed at a preclinical level, its clinical application is restricted by a number of factors, including the low targeting efficiency that stems from the characteristics of RME. One important approach to overcome this is to improve the drug delivery system by a series of chemical modifications and evaluate the drug targeting efficiency from a kinetic point of view.
Kato
Y
Y
Faculty of Pharmaceutical Sciences, University of Tokyo, Japan.
Sugiyama
Y
Y
D000818:Animals; D016503:Drug Delivery Systems; D004705:Endocytosis / Q000502:physiology*; D018014:Gene Transfer Techniques; D006801:Humans; D010455:Peptides / Q000008:administration & dosage*; D011506:Proteins / Q000008:administration & dosage*; D011956:Receptors, Cell Surface / Q000502:physiology*
D010455:Peptides; D011506:Proteins; D011956:Receptors, Cell Surface