Immunomodulatory responses to delta-opioid receptor ligands in human lymphocytes.
In phytohemagglutinin (PHA) activated human peripheral blood mononuclear cells. [3H]thymidine uptake and interferon gamma production were increased by the delta-opioid receptor agonist, deltorphin-I (10(-14)-10(-10) M) and by the delta-opioid antagonist naltrindole (10(-13)-10(-9) M). Combination of 10-9 M naltrindole with deltrophin-I (10(-12)-10(-8)M) significantly inhibited the proliferative response but did not affect interferon production.
Noviello
L
L
Institute of Medical Pharmacology, University La Supienza, Rome, Italy.
Papadia
S
S
Capobianchi
M R
MR
Negri
L
L
D000701:Analgesics, Opioid / Q000494:pharmacology; D006801:Humans; D007371:Interferon-gamma / Q000097:blood; D007963:Leukocytes, Mononuclear / Q000187:drug effects / Q000276:immunology* / Q000378:metabolism; D008024:Ligands; D008213:Lymphocyte Activation; D009271:Naltrexone / Q000031:analogs & derivatives* / Q000494:pharmacology; D009292:Narcotic Antagonists / Q000494:pharmacology; D009842:Oligopeptides / Q000494:pharmacology*; D010835:Phytohemagglutinins / Q000494:pharmacology; D017465:Receptors, Opioid, delta / Q000187:drug effects / Q000378:metabolism*; D013936:Thymidine / Q000378:metabolism
D000701:Analgesics, Opioid; D008024:Ligands; D009292:Narcotic Antagonists; D009842:Oligopeptides; D010835:Phytohemagglutinins; D017465:Receptors, Opioid, delta; C060208:deltorphin I, Ala(2)-; D009271:Naltrexone; D007371:Interferon-gamma; C055382:naltrindole; D013936:Thymidine