Biperiden and haloperidol plasma levels and extrapyramidal side effects in schizophrenic patients.
Anticholinergic drugs such as biperiden are used for the treatment of extrapyramidal side effects (EPS) induced by neuroleptics such as haloperidol. The effects of biperiden and haloperidol plasma levels on EPS were studied in 29 chronically ill schizophrenics. The results show relationships between biperiden dose and biperiden plasma levels (BPL), and between BPL and haloperidol plasma levels (HPL). Neither BPL nor HPL seem to influence EPS.
Meszaros
K
K
Department of General Psychiatry, University Hospital of Psychiatry, Vienna, Austria.
Lenzinger
E
E
Hornik
K
K
Schönbeck
G
G
Hatzinger
R
R
Langer
G
G
Sieghart
W
W
Aschauer
H N
HN
D000328:Adult; D000368:Aged; D018726:Anti-Dyskinesia Agents / Q000008:administration & dosage / Q000097:blood* / Q000627:therapeutic use*; D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000097:blood*; D001480:Basal Ganglia Diseases / Q000097:blood* / Q000139:chemically induced / Q000188:drug therapy*; D001712:Biperiden / Q000008:administration & dosage / Q000097:blood* / Q000627:therapeutic use*; D002908:Chronic Disease; D004305:Dose-Response Relationship, Drug; D006220:Haloperidol / Q000009:adverse effects* / Q000097:blood*; D006801:Humans; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000150:complications / Q000188:drug therapy*
D018726:Anti-Dyskinesia Agents; D014150:Antipsychotic Agents; D001712:Biperiden; D006220:Haloperidol