title: Annexin V-coated intraocular lenses.
abstract: OBJECTIVE
  To assess whether annexin V-coated poly(methyl methacrylate) (PMMA) intraocular lenses (IOLs) prevent postoperative inflammation in rabbit eyes.
  
  
  METHODS
  Department of Ophthalmology, Hôpital Purpan, Toulouse, France.
  
  
  METHODS
  Thirteen IOLs coated with annexin V were implanted in 13 rabbit eyes; the contralateral eyes received uncoated IOLs. Postoperative fibrin was quantitated by daily slitlamp examination until the anterior chamber was completely clear. Results were analyzed using a Wilcoxon test. Ocular toxicity was evaluated by light and electron microscopy.
  
  
  RESULTS
  Eyes with the annexin V-coated IOLs had less severe inflammation on the first postoperative day, and the inflammation resolved more quickly than in eyes with uncoated IOLs (P < .05). No annexin V was released postoperatively, nor were there signs of ocular toxicity.
  
  
  CONCLUSIONS
  Annexin V-coated lenses effectively reduced postoperative inflammation in rabbit eyes.
authors.affiliation: Department of Ophthalmology, Purpan Hospital, Toulouse, France.
authors.forename: P
authors.initials: P
authors.lastname: Chollet
authors.forename: F
authors.initials: F
authors.lastname: Malecaze
authors.forename: P
authors.initials: P
authors.lastname: Le Toan
authors.forename: H
authors.initials: H
authors.lastname: Lamche
authors.forename: J L
authors.initials: JL
authors.lastname: Arné
mesh_terms: D000818:Animals; D017304:Annexin A5 / Q000032:analysis / Q000378:metabolism*; D002387:Cataract Extraction / Q000009:adverse effects; D009877:Endophthalmitis / Q000209:etiology / Q000517:prevention & control*; D004797:Enzyme-Linked Immunosorbent Assay; D005337:Fibrin / Q000378:metabolism; D005500:Follow-Up Studies; D005549:Foreign-Body Reaction / Q000209:etiology / Q000517:prevention & control; D007910:Lenses, Intraocular; D008768:Methylmethacrylates / Q000378:metabolism*; D011183:Postoperative Complications / Q000209:etiology / Q000517:prevention & control*; D011817:Rabbits
chemical_list: D017304:Annexin A5; D008768:Methylmethacrylates; D005337:Fibrin