title: Patterns of failure and long-term results in high-risk resected gastric cancer treated with postoperative radiotherapy with or without intraoperative electron boost.
abstract: BACKGROUND
  To evaluate the possible role of adjuvant radiotherapy in the management of high-risk resected gastric carcinoma.
  
  
  METHODS
  From 1982 to 1993, 62 patients surgically resected of a primary gastric cancer with adverse pathological features (serosal and/or regional lymph node involvement) were treated with postoperative radiotherapy with (Group I) or without (Group II) intraoperative electron boost to the surgical bed and coeliac axis (IORT).
  
  
  RESULTS
  After a median follow-up of 75.6 months (range 4-120+) for IORT patients and 91.2 months (range 6-149+) for non-IORT patients, overall relapse rates for Group I and Group II patients were 44.5% and 48.6% and local-regional relapse rates were 11.1% and 20%, respectively. Actuarial survival rates projected at the maximum follow-up were 41% and 38% in Groups I and II, respectively.
  
  
  CONCLUSIONS
  This retrospective analysis suggests a beneficial effect of adjuvant external radiotherapy in promoting local-regional control in high-risk resected gastric cancer.
authors.affiliation: Department of Oncology, Clinica Universitaria de Navarra, Pamplona, Spain.
authors.forename: R
authors.initials: R
authors.lastname: Martínez-Monge
authors.forename: F A
authors.initials: FA
authors.lastname: Calvo
authors.forename: I
authors.initials: I
authors.lastname: Azinovic
authors.forename: J J
authors.initials: JJ
authors.lastname: Aristu
authors.forename: J L
authors.initials: JL
authors.lastname: Hernández
authors.forename: F
authors.initials: F
authors.lastname: Pardo
authors.forename: P
authors.initials: P
authors.lastname: Fernández
authors.forename: J
authors.initials: J
authors.lastname: García-Foncillas
authors.forename: J
authors.initials: J
authors.lastname: Alvarez-Cienfuegos
mesh_terms: D000328:Adult; D000368:Aged; D004583:Electrons / Q000627:therapeutic use; D005743:Gastrectomy; D006801:Humans; D007430:Intraoperative Care; D008875:Middle Aged; D018714:Radiotherapy, Adjuvant; D011882:Radiotherapy, High-Energy; D012189:Retrospective Studies; D012306:Risk; D013274:Stomach Neoplasms / Q000401:mortality* / Q000532:radiotherapy* / Q000601:surgery; D015996:Survival Rate; D017211:Treatment Failure