title: Medullary thick limb basolateral Cl- channels.
abstract: Chloride transport by the medullary thick ascending limb is a major determinant of urinary concentrating and diluting power and also of tubuloglomerular feedback. In this review, we discuss the electrophysiologic, regulatory, and molecular features of a Cl- channel present in basolateral membranes from the medullary thick ascending limb. Functional and immunohistochemical data support the view that rbCIC-Ka, a CIC Cl- channel cloned from rabbit kidney medulla, may be the Cl- channel which mediates basolateral Cl- efflux.
authors.affiliation: Department of Internal Medicine, University of Arkansas College of Medicine, Little Rock, USA.
authors.forename: W B
authors.initials: WB
authors.lastname: Reeves
authors.forename: C J
authors.initials: CJ
authors.lastname: Winters
authors.forename: L
authors.initials: L
authors.lastname: Zimniak
authors.forename: T E
authors.initials: TE
authors.lastname: Andreoli
mesh_terms: D000818:Animals; D018118:Chloride Channels / Q000235:genetics / Q000502:physiology*; D002712:Chlorides / Q000378:metabolism; D003001:Cloning, Molecular; D007671:Kidney Concentrating Ability / Q000235:genetics / Q000502:physiology*; D007686:Kidney Tubules, Distal / Q000502:physiology*; D008051:Lipid Bilayers; D051379:Mice; D011817:Rabbits; D014667:Vasopressins / Q000502:physiology; D014882:Water-Electrolyte Balance / Q000235:genetics / Q000502:physiology*
chemical_list: D018118:Chloride Channels; D002712:Chlorides; D008051:Lipid Bilayers; D014667:Vasopressins