[Study on the level of soluble interleukin-2 receptor, expression of membrane interleukin-2 receptor and T lymphocyte subpopulations in pulmonary tuberculosis].
OBJECTIVE
To evaluate the significance of soluble interleukin-2 receptor (sIL-2R), membrane interleukin-2 receptor (mIL-2R) and T lymphocyte subpopulations in development of pulmonary tuberculosis.


METHODS
The level of sIL-2R, expression of mIL-2R and the profile of T lymphocyte subpopulations in patients with pulmonary tuberculosis were tested by sandwiched ELISA and alkaline phosphatase-antialkaline phosphate (APAAP) methods.


RESULTS
The levels of sIL-2R, CD8 were higher, and expression of mIL-2R, CD4, CD4/CD8 ratio were lower in pulmonary tuberculosis than those in normal controls (P < 0.001). And the changes of all indicators in patients with cavitation were more obvious than those in patients without (P < 0.001), the changes in progressive stage were more obvious than those in stable and improving stages (P < 0.001).


CONCLUSIONS
The results indicated that the patients, condition and prognosis of pulmonary tuberculosis were related to the changes of sIL-2R level, mIL-2R expression and T lymphocyte subpopulations.
Liu
C
C
Department of Diagnostics, Qingdan Medical College.
Teng
Q
Q
Xing
S
S
D000328:Adult; D016516:CD4-CD8 Ratio; D002462:Cell Membrane / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015375:Receptors, Interleukin-2 / Q000097:blood*; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D013601:T-Lymphocytes / Q000378:metabolism*; D014397:Tuberculosis, Pulmonary / Q000276:immunology*
D015375:Receptors, Interleukin-2