title: Behavioral and P3 amplitude enhancement in schizophrenia following feedback training.
abstract: In order to clarify the remediability of behavioral and electrophysiological abnormalities in schizophrenia, hit rate, reaction time, and P3 amplitude from auditory event-related potentials were evaluated before and after feedback training of a task in 14 schizophrenics and 12 age-matched normal controls. Although mean changes in the three indices due to the training were nonsignificant in both schizophrenic and normal control groups as a whole, the changes in hit rate and reaction time correlated significantly with the P3 amplitude change in the schizophrenic (r = 0.60 and -0.58, respectively) but not in the normal control group. The P3 amplitude change also correlated with the P3 amplitude before the training only in the schizophrenic group (r = -0.68), suggesting that the training was more effective for the schizophrenic patients with marked P3 amplitude reduction. The observed P3 amplitude increase due to training may represent an electrophysiological correlate of a remediable aspect of behavioral deficits in schizophrenics, which may underlie the effectiveness of nonpharmacological treatments.
authors.affiliation: Department of Neuropsychiatry, Faculty of Medicine, University of Tokyo, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Fukuda
authors.forename: S
authors.initials: S
authors.lastname: Niwa
authors.forename: K
authors.initials: K
authors.lastname: Hiramatsu
authors.forename: A
authors.initials: A
authors.lastname: Hata
authors.forename: O
authors.initials: O
authors.lastname: Saitoh
authors.forename: S
authors.initials: S
authors.lastname: Hayashida
authors.forename: K
authors.initials: K
authors.lastname: Nakagome
authors.forename: A
authors.initials: A
authors.lastname: Iwanami
authors.forename: T
authors.initials: T
authors.lastname: Sasaki
authors.forename: H
authors.initials: H
authors.lastname: Honda
authors.forename: K
authors.initials: K
authors.lastname: Itoh
mesh_terms: D000328:Adult; D001143:Arousal / Q000502:physiology*; D001288:Attention / Q000502:physiology*; D002540:Cerebral Cortex / Q000503:physiopathology; D004569:Electroencephalography; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D005246:Feedback / Q000502:physiology*; D005260:Female; D005583:Fourier Analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D010897:Pitch Discrimination / Q000502:physiology; D011930:Reaction Time / Q000502:physiology*; D012559:Schizophrenia / Q000175:diagnosis / Q000503:physiopathology* / Q000534:rehabilitation; D012815:Signal Processing, Computer-Assisted