Complement-modulating properties of a kaempferol 7-O-rhamnosylsophoroside from the leaves of Morinda morindoides.
A kaempferol 7-O-rhamnosylsophoroside isolated from the leaves of Morinda morindoides showed dose-dependent complement-modulating properties towards both the classical (inhibiting effect) and alternative (activating effect) pathways of the complement system. Its structure was elucidated by chemical and spectroscopic methods as kaempferol 7-O-[alpha-L-rhamnopyranosyl-(1-->6)]-[beta-D-glucopyranosyl-(1-->2)]-be ta-D-glucopyranoside, a new natural product which was named morindaoside.
Cimanga
K
K
Department of Pharmaceutical Sciences, University of Antwerp (U.I.A.), Belgium.
de Bruyne
T
T
Van Poel
B
B
Ma
Y
Y
Claeys
M
M
Pieters
L
L
Kambu
K
K
Tona
L
L
Bakana
P
P
Vanden Berghe
D
D
Vlietinck
A J
AJ
D002240:Carbohydrate Sequence; D003167:Complement Activation / Q000187:drug effects*; D005419:Flavonoids; D006027:Glycosides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D044949:Kaempferols; D008519:Medicine, Traditional; D008969:Molecular Sequence Data; D015394:Molecular Structure; D018515:Plant Leaves; D010946:Plants, Medicinal; D011794:Quercetin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
D005419:Flavonoids; D006027:Glycosides; D044949:Kaempferols; C107157:morindaoside; C006552:kaempferol; D011794:Quercetin