title: DNA supercoiling and bacterial adaptation: thermotolerance and thermoresistance.
abstract: When bacterial cells are shifted to higher temperatures their degree of DNA supercoiling changes. Topoisomerases are involved in bacterial adaptation to environmental changes requiring rapid shifts in gene expression. This role in heat shock has been elucidated by genetic studies on the Escherichia coli topA gene and its sigma 32-dependent promoter, P1. Other studies have shown that certain gyrA mutants have increased thermoresistance.
authors.affiliation: Dept of Biochemistry and Molecular Biology, New York Medical College, Valhalla 10595, USA. yuk-ching_tse-dinh@nymc.edu
authors.forename: Y C
authors.initials: YC
authors.lastname: Tse-Dinh
authors.forename: H
authors.initials: H
authors.lastname: Qi
authors.forename: R
authors.initials: R
authors.lastname: Menzel
mesh_terms: D000222:Adaptation, Physiological; D001419:Bacteria / Q000737:chemistry / Q000235:genetics; D018407:Bacterial Physiological Phenomena; D027081:DNA Gyrase; D004250:DNA Topoisomerases, Type II / Q000235:genetics / Q000378:metabolism; D004269:DNA, Bacterial / Q000737:chemistry*; D004278:DNA, Superhelical / Q000737:chemistry*; D004926:Escherichia coli / Q000737:chemistry / Q000235:genetics / Q000502:physiology; D005798:Genes, Bacterial; D011401:Promoter Regions, Genetic; D013696:Temperature
chemical_list: D004269:DNA, Bacterial; D004278:DNA, Superhelical; D027081:DNA Gyrase; D004250:DNA Topoisomerases, Type II