title: The possible effect of pregnancy on Ménière's disease.
abstract: There are few reports on the course of Ménière's disease during pregnancy. We report here the clinical course of Ménière's disease before, during and after pregnancy and discuss the possible effect of pregnancy on Ménière's disease and the treatment of Ménière's disease during pregnancy. In the present case, the vertigo attacks increased up to 10 times per month during early pregnancy, when the serum osmolality was significantly below normal at 268 mosm/kg. As the pregnancy proceeded, the serum osmolality normalized and the vertigo attacks decreased in frequency. The vertigo attacks were treated by oral isosorbide and intramuscular injection of low-dose diazepam. The coincidence of the decline in osmolality with the increase in vertigo attacks points to serum osmolality as a possible factor in the effect of pregnancy on Ménière's disease.
authors.affiliation: Department of Obstetrics and Gynecology, School of Medicine, Kanazawa University, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Uchide
authors.forename: N
authors.initials: N
authors.lastname: Suzuki
authors.forename: T
authors.initials: T
authors.lastname: Takiguchi
authors.forename: S
authors.initials: S
authors.lastname: Terada
authors.forename: M
authors.initials: M
authors.lastname: Inoue
mesh_terms: D000328:Adult; D001300:Audiometry, Evoked Response / Q000379:methods; D001301:Audiometry, Pure-Tone; D002150:Caloric Tests / Q000379:methods; D003975:Diazepam / Q000627:therapeutic use; D018159:Endolymphatic Hydrops / Q000175:diagnosis / Q000188:drug therapy; D016057:Evoked Potentials, Auditory, Brain Stem; D005260:Female; D018757:GABA Modulators / Q000627:therapeutic use; D006319:Hearing Loss, Sensorineural / Q000175:diagnosis / Q000209:etiology; D006634:Histamine H1 Antagonists / Q000627:therapeutic use; D006801:Humans; D008575:Meniere Disease / Q000175:diagnosis / Q000188:drug therapy; D009994:Osmolar Concentration; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis / Q000188:drug therapy; D012720:Severity of Illness Index; D014717:Vertigo / Q000175:diagnosis / Q000188:drug therapy
chemical_list: D018757:GABA Modulators; D006634:Histamine H1 Antagonists; D003975:Diazepam