title: Severe vulvar vestibulitis. Relation to HPV infection.
abstract: OBJECTIVE
  To determine whether patients with human papillomavirus (HPV)-associated vestibulitis present differently from patients with HPV-negative disease and whether the presence of HPV is a predictor of the outcome of surgical treatment by perineoplasty.
  
  
  METHODS
  Thirty-eight women with severe vulvar vestibulitis who underwent surgical perineoplasty were found to have HPV DNA in the vestibule by polymerase chain reaction. Thirty-six other women with severe vestibulitis had no HPV DNA in the surgical specimen. The two groups were compared with regard to demographic, social and medical variables as well as physical findings in the vestibule and response to operative treatment.
  
  
  RESULTS
  Both groups were found to be similar in respect to age (mean 25.9 +/- 7.93 versus 25.47 +/- 5.8, respectively), parity, education, smoking habits, contraceptive use, presence of primary vestibulitis, presence of dysuria and involvement of the whole vestibule (both anterior and posterior). More unmarried than married women were infected with HPV (P < .002). There was no significant correlation between the presence of HPV and the outcome of surgical treatment (P < .6, relative risk = 0.9, 95% confidence interval = 0.5-1.5).
  
  
  CONCLUSIONS
  Although HPV DNA was found in more than half of women with vestibulitis, it appears to play no role in the presentation or response to surgical therapy for vulvar vestibulitis.
authors.affiliation: Department of Obstetrics and Gynaecology, Carmel Medical Center, Technion-Israel Institute of Technology, Haifa, Israel.
authors.forename: J
authors.initials: J
authors.lastname: Bornstein
authors.forename: S
authors.initials: S
authors.lastname: Shapiro
authors.forename: N
authors.initials: N
authors.lastname: Goldshmid
authors.forename: Z
authors.initials: Z
authors.lastname: Goldik
authors.forename: N
authors.initials: N
authors.lastname: Lahat
authors.forename: H
authors.initials: H
authors.lastname: Abramovici
mesh_terms: D000293:Adolescent; D000328:Adult; D003270:Contraceptive Agents; D004279:DNA, Viral / Q000032:analysis; D004522:Educational Status; D005260:Female; D006801:Humans; D017533:Marital Status; D008875:Middle Aged; D027383:Papillomaviridae / Q000235:genetics; D030361:Papillomavirus Infections / Q000601:surgery / Q000821:virology; D010298:Parity; D016133:Polymerase Chain Reaction; D012907:Smoking; D014626:Vaginal Smears; D014847:Vulvitis / Q000601:surgery / Q000821:virology*
chemical_list: D003270:Contraceptive Agents; D004279:DNA, Viral