Steady state EP is not responsible for hearing loss in adult chickens following acoustic trauma.
The steady state DC endocochlear potential (EP) in young chicks shows a large decrease after acoustic overstimulation followed by a rapid recovery that parallels the recovery of threshold (Poje et al., Hear. Res. 82 (1995) 197-204). These results raise a question as to whether or not the EP could account for the hearing loss and make a significant contribution to the recovery of the threshold. In contrast to results in young chicks, we show that acoustic overstimulation, which causes extensive hair cell damage, does not cause a decrease in the steady state EP in adult chickens. However, there is a significant reduction in the negative EP seen during anoxia which persists even after 4 weeks of recovery. Thus, our results indicate that the steady state EP cannot account for the hearing loss observed in adult chickens.
Trautwein
P G
PG
Center for Hearing and Deafness, State University of New York at Buffalo, 14214, USA.
Chen
L
L
Salvi
R J
RJ
D000161:Acoustic Stimulation; D000818:Animals; D001309:Auditory Threshold / Q000502:physiology*; D002645:Chickens; D003055:Cochlear Microphonic Potentials / Q000502:physiology*; D004195:Disease Models, Animal; D005260:Female; D006198:Hair Cells, Auditory / Q000473:pathology; D006317:Hearing Loss, Noise-Induced / Q000503:physiopathology*; D012405:Round Window, Ear / Q000502:physiology