An association between increased serum-soluble interleukin-2 receptors and a disturbance in muscle force in schizophrenic patients.
1. Serum-soluble interleukin-2 receptors (SIL-2Rs), a sign of immune activation, are increased in approximately 30% of schizophrenic subjects. 2. In a recent publication the authors found that SIL-2Rs were particularly elevated in schizophrenic subjects with tardive dyskinesia (TD). 3. This paper investigates the relationship between muscle force instability and SIL-2Rs in 32 schizophrenic patients, 10 of whom were neuroleptic-naive. 4. The authors hypothesized that there would be a positive correlation between increased levels of SIL-2Rs and muscle force instability. 5. Serum SIL-2Rs and muscle force instability were positively correlated (r = 0.54, p < .001) in the schizophrenic patients, and this correlation held even for the subset of neuroleptic-naive patients (r = .73, df 8, p = .016). 6. These findings suggest that there is an important correlation between immune activation and muscle force instability in schizophrenic patients.
Rapaport
M H
MH
Department of Psychiatry, University of California, San Diego, La Jolla, USA.
Caligiuri
M P
MP
Lohr
J B
JB
D000328:Adult; D004409:Dyskinesia, Drug-Induced / Q000503:physiopathology; D006801:Humans; D007537:Isometric Contraction / Q000502:physiology; D008297:Male; D018482:Muscle, Skeletal / Q000503:physiopathology*; D011569:Psychiatric Status Rating Scales; D015375:Receptors, Interleukin-2 / Q000097:blood*; D012559:Schizophrenia / Q000378:metabolism* / Q000503:physiopathology*
D015375:Receptors, Interleukin-2