[The psychophysiological aspects of treating obesity with Izolipan].
20 patients with obesity were examined. Their weight was increased as compared with ideal values by 30-140%. The patients were characterized by anxious or depressive disturbances (Spilberger's and Beck tests) and alterations of alimentary behaviour in form of prevalence of emotional and external alimentary behaviour (EMAB and EAB, respectively). The study of cognitive negative variations (CNV) revealed the decrease of late wave's area, which correlated reversely with levels of anxiety, depression and EMAB expression. The Isolipan administration (15 mg, 2 times/daily during 3 months) together with hypocaloric diet resulted in average weight loss equal to 12.3 kg in the whole group. These changes correlated well with normalization of both alimentary behaviour (in the form of decrease of EMAB and EAB indices) and emotional state, and increase of decreased late CNV with disappearance of pathological psycho-physiological correlations between CNV and emotional state.
Voznesenskaia
T G
TG
Filatova
E G
EG
Solov'eva
A D
AD
D000161:Acoustic Stimulation; D000328:Adult; D001067:Appetite Depressants / Q000627:therapeutic use*; D001921:Brain / Q000187:drug effects / Q000503:physiopathology; D003265:Contingent Negative Variation / Q000187:drug effects; D004341:Drug Evaluation; D005260:Female; D005277:Fenfluramine / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D009767:Obesity, Morbid / Q000188:drug therapy* / Q000503:physiopathology / Q000523:psychology; D011581:Psychological Tests; D011603:Psychophysiology; D013997:Time Factors
D001067:Appetite Depressants; D005277:Fenfluramine