Management of adenocarcinoma arising in Barrett's esophagus.
Esophageal adenocarcinoma is a highly malignant tumor and, if not diagnosed at an early stage, carries a poor prognosis. Controversy exists over how to manage carcinoma of the esophagus confined to the mucosa and the extent of resection to cure disease that has extended beyond the mucosa. Similarly, there are differing opinions regarding the role of adjuvant chemotherapy and the efficacy of surgical resection for palliation. These issues are discussed as they pertain to the management of adenocarcinoma arising in Barrett's esophagus.
DeMeester
T R
TR
Department of Surgery, University of Southern California School of Medicine, Los Angeles 90033-4612, USA.
D000230:Adenocarcinoma / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D000465:Algorithms; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001471:Barrett Esophagus / Q000473:pathology*; D017024:Chemotherapy, Adjuvant; D003680:Deglutition Disorders / Q000145:classification; D018450:Disease Progression; D004938:Esophageal Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D016629:Esophagectomy / Q000379:methods; D006801:Humans; D009367:Neoplasm Staging; D010166:Palliative Care; D011230:Precancerous Conditions / Q000473:pathology*