Effects of siegesbeckia pubescens on immediate hypersensitivity reaction.
This study was carried out to examine the effect of an aqueous extract from Siegesbeckia pubescens (Compositae) (SPAE) on immunoglobulin E (IgE)-mediated immediate hypersensitivity reaction. Forty-eight hours passive cutaneous anaphylaxis in rats was significantly inhibited by oral administration of SPAE (100 micrograms/g). It also inhibited histamine release from rat peritoneal mast cells induced by anti-dinitrophenyl (DNP)-IgE and DNP-human serum albumin. The data indicate that SPAE has antiallergic activity, and that its action may be due to inhibition of histamine release from mast cells.
Kim
H M
HM
Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University, Iksan, Chonbuk, South Korea.
D000818:Animals; D006967:Hypersensitivity / Q000188:drug therapy*; D008407:Mast Cells / Q000187:drug effects; D008518:Medicine, East Asian Traditional; D051381:Rats; D017207:Rats, Sprague-Dawley