R-form lipopolysaccharides (LPS) of Gram-negative bacteria as possible vaccine antigens.
The antigenic and immunogenic properties of R-form lipopolysaccharides (LPS) of Pseudomonas aeruginosa, Salmonella spp., Escherichia coli and Shigella spp. were studied. The results showed the presence of antigenic relationships among P. aeruginosa R mutants with different structures of the LPS core lipid A region and also among E. coli, Shigella and P. aeruginosa R-LPS, but not with S. minnesota Re-LPS. Vaccines prepared with R-LPS proved to be effective preparations for the active immunization of mice against P. aeruginosa infection. The vaccine stimulated 40-100% protection in mice depending upon the scheme of immunization.
Stanislavsky
E S
ES
I.I. Mechnikov Research Institute for Vaccines and Sera, Moscow, Russia.
Makarenko
T A
TA
Kholodkova
E V
EV
Lugowski
C
C
D000371:Agglutination; D000818:Animals; D000942:Antigens, Bacterial / Q000276:immunology*; D001428:Bacterial Vaccines / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D004926:Escherichia coli / Q000276:immunology; D005260:Female; D006090:Gram-Negative Bacteria / Q000276:immunology*; D008070:Lipopolysaccharides / Q000276:immunology*; D008297:Male; D051379:Mice; D009154:Mutation; D011552:Pseudomonas Infections / Q000517:prevention & control*; D011550:Pseudomonas aeruginosa / Q000235:genetics / Q000276:immunology; D011817:Rabbits; D012475:Salmonella / Q000276:immunology; D012760:Shigella / Q000276:immunology
D000942:Antigens, Bacterial; D001428:Bacterial Vaccines; D008070:Lipopolysaccharides