title: Benzydamine inhibits the release of tumor necrosis factor-alpha and monocyte chemotactic protein-1 by Candida albicans-stimulated human peripheral blood cells.
abstract: Benzydamine is a non-steroidal antiinflammatory drug, devoid of activity on arachidonic acid metabolism, which is extensively used as a topical drug in inflammatory conditions, particularly for the treatment of bacterial vaginosis and Candida albicans-sustained vaginitis. In the present study the effects of benzydamine on the production of several inflammatory cytokines were examined in cultures of Candida albicans-stimulated human mononuclear cells. Benzydamine (6.25-50 microM) inhibited Candida-induced tumor necrosis factor-alpha and, to a lesser extent, interleukin-1 beta production, whereas it did not affect interleukin-6 release. Benzydamine also blocked monocyte chemotactic protein-1 secretion, but it did not affect interleukin-8 production. Unlike benzydamine, ibuprofen and naproxen, two non-steroidal antiinflammatory drugs also used topically, were unable to suppress inflammatory lymphokine production from Candida-activated mononuclear cells. These data suggest that benzydamine may be effective in local Candida infections at least in part by suppressing inflammatory cytokine and monokine production in the vaginal mucosa and consequently decreasing their levels in vaginal secretions.
authors.affiliation: Istituto Ricerche Farmacologiche M. Negri, Milan, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Sironi
authors.forename: C
authors.initials: C
authors.lastname: Milanese
authors.forename: A
authors.initials: A
authors.lastname: Vecchi
authors.forename: L
authors.initials: L
authors.lastname: Polenzani
authors.forename: A
authors.initials: A
authors.lastname: Guglielmotti
authors.forename: I
authors.initials: I
authors.lastname: Coletta
authors.forename: C
authors.initials: C
authors.lastname: Landolfi
authors.forename: L
authors.initials: L
authors.lastname: Soldo
authors.forename: A
authors.initials: A
authors.lastname: Mantovani
authors.forename: M
authors.initials: M
authors.lastname: Pinza
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001591:Benzydamine / Q000494:pharmacology*; D002177:Candidiasis / Q000188:drug therapy* / Q000276:immunology; D018932:Chemokine CCL2 / Q000378:metabolism*; D005260:Female; D006801:Humans; D007052:Ibuprofen / Q000494:pharmacology; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology / Q000382:microbiology; D009288:Naproxen / Q000494:pharmacology; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*; D014627:Vaginitis / Q000188:drug therapy
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D018932:Chemokine CCL2; D014409:Tumor Necrosis Factor-alpha; D001591:Benzydamine; D009288:Naproxen; D007052:Ibuprofen