title: Klinefelter syndrome and non-Hodgkin lymphoma.
abstract: Patients with a 47,XXY karyotype (Klinefelter syndrome) appear to have an increased risk of developing cancer, especially male breast cancer and germ cell tumors, but rarely malignant hematologic disorders. We report a patient with a low grade B-cell non-Hodgkin lymphoma with a 47,XXY karyotype in both the tumor and constitutional cells. This is only the 13th reported case of malignant lymphoma in a patient with Klinefelter syndrome. Although some authors postulate that the 47,XXY karyotype may be a predisposing factor in the development of hematological malignancies, the lack of reported cases suggests that such associations may be no more than chance findings.
authors.affiliation: Cytogenetic Laboratory, Belfast City Hospital, Northern Ireland.
authors.forename: M
authors.initials: M
authors.lastname: Humphreys
authors.forename: P
authors.initials: P
authors.lastname: Lavery
authors.forename: C
authors.initials: C
authors.lastname: Morris
authors.forename: N
authors.initials: N
authors.lastname: Nevin
mesh_terms: D000368:Aged; D006801:Humans; D007713:Klinefelter Syndrome / Q000150:complications*; D016393:Lymphoma, B-Cell / Q000150:complications*; D008297:Male