Kaposi's sarcoma as manifestation of immunosuppression in organ transplant recipients.
We report 2 patients, negative for human immunodeficiency virus (HIV) antibodies, who developed generalized Kaposi's sarcoma (KS), one 5 months after renal transplantation while receiving cyclosporin A and prednisone, and the other 24 months after heart transplantation while receiving cyclosporin A, azathioprine and prednisone. Reduction of the immunosuppressive therapy combined with chemotherapy and radiotherapy in both cases led to a remission of KS without development of transplant rejection.
Aebischer
M C
MC
Dermatological Clinic, Inselspital, University of Berne, Switzerland.
Zala
L B
LB
Braathen
L R
LR
D000893:Anti-Inflammatory Agents / Q000009:adverse effects; D001379:Azathioprine / Q000009:adverse effects; D003131:Combined Modality Therapy; D016572:Cyclosporine / Q000009:adverse effects; D006084:Graft Rejection / Q000517:prevention & control; D016027:Heart Transplantation / Q000009:adverse effects*; D006801:Humans; D016867:Immunocompromised Host; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D016030:Kidney Transplantation / Q000009:adverse effects*; D008175:Lung Neoplasms / Q000188:drug therapy / Q000209:etiology / Q000532:radiotherapy; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000188:drug therapy / Q000209:etiology / Q000532:radiotherapy; D011241:Prednisone / Q000009:adverse effects; D012074:Remission Induction; D012514:Sarcoma, Kaposi / Q000188:drug therapy / Q000209:etiology* / Q000532:radiotherapy; D012878:Skin Neoplasms / Q000188:drug therapy / Q000209:etiology* / Q000532:radiotherapy; D013274:Stomach Neoplasms / Q000188:drug therapy / Q000209:etiology / Q000532:radiotherapy
D000893:Anti-Inflammatory Agents; D007166:Immunosuppressive Agents; D016572:Cyclosporine; D001379:Azathioprine; D011241:Prednisone