[Targeted action proteins as potential drugs].
The data available in the literature over the past decade as to the design and use of directly acting proteins in the treatment of a number of diseases are analyzed. The structure and functions of toxins inhibiting protein synthesis are reviewed. The structural and functional properties of conjugated and recombinant immunotoxins are compared and clinical findings are reviewed. Particular emphasis is laid on the requirements for such hybrid proteins. It is concluded that specific cell elimination as a principal approach to treating tumors, autoimmune and other diseases will find wide medical application just in the near future.
Anisimova
V A
VA
State Scientific Center of Applied Microbiology, Obolensk.
Kopylov
P K
PK
Shemianin
I G
IG
D000942:Antigens, Bacterial / Q000276:immunology; D001327:Autoimmune Diseases / Q000628:therapy; D001427:Bacterial Toxins / Q000276:immunology*; D006801:Humans; D000922:Immunotoxins / Q000494:pharmacology*; D009369:Neoplasms / Q000628:therapy; D011994:Recombinant Proteins
D000942:Antigens, Bacterial; D001427:Bacterial Toxins; D000922:Immunotoxins; D011994:Recombinant Proteins