The observation of complement activation and polymorphonuclear neutrocytopenia during cardiopulmonary bypass.
By determining the plasma levels of C2, C4, factor B and polymorphonuclear neutrophils (PMNs) of the patients who received CPB, the path of complement activation and changes of PMNs were studied. The results suggest that complement system was activated through alternative pathway during CPB and was activated through classic pathway after CPB. The anaphylatoxin, the products of complement activation may be responsible for the polymorphonuclear neutrocytopenia.
Wang
D
D
Department of Cardiovascular Surgery, Tongji Medical University, Wuhan.
Fu
P
P
Cai
J
J
Lan
H
H
D000293:Adolescent; D000328:Adult; D002315:Cardiopulmonary Bypass / Q000009:adverse effects; D002648:Child; D003167:Complement Activation; D003176:Complement C3 / Q000378:metabolism; D003181:Complement C4 / Q000378:metabolism; D005260:Female; D006344:Heart Septal Defects, Atrial / Q000276:immunology / Q000601:surgery; D006345:Heart Septal Defects, Ventricular / Q000276:immunology / Q000601:surgery; D006349:Heart Valve Diseases / Q000276:immunology / Q000601:surgery; D006801:Humans; D008297:Male; D009503:Neutropenia / Q000209:etiology*
D003176:Complement C3; D003181:Complement C4