title: [A case of breast cancer metastasis to the skin and bone 13 years after, and to the brain 17 years after mastectomy].
abstract: A case of breast cancer metastasis to the skin and bone 13 years after, and to the brain 17 years after mastectomy in a 54-year-old woman, is reported. In 1978, the patient, who was then 37 years old, underwent standard radical mastectomy for left breast cancer. In 1991, because of skin and bone metastasis, systemic chemotherapy with cyclophosphamide, epirubicin, and 5-fluorouracil (CAF) was performed, and she partially responded to CAF therapy. In April 1995, the patient was admitted for pain of left hip joint and left knee joint. Computed tomography of the head revealed a bleeding tumor with marked peritumoral edema. Serum levels of carcinoembryonic antigen (250 ng/ml) and CA 15-3 (810 U/ml) were increased. Bone metastases were found elsewhere in the body. Again, systemic chemotherapy with CAF was performed. CAF chemotherapy stopped the brain metastasis bleeding.
authors.affiliation: Dept. of Surgery, Makino Hospital.
authors.forename: T
authors.initials: T
authors.lastname: Itoshima
authors.forename: T
authors.initials: T
authors.lastname: Yamamoto
authors.forename: T
authors.initials: T
authors.lastname: Kasamatsu
authors.forename: H
authors.initials: H
authors.lastname: Fujino
authors.forename: H
authors.initials: H
authors.lastname: Yamamoto
authors.forename: Y
authors.initials: Y
authors.lastname: Morita
authors.forename: M
authors.initials: M
authors.lastname: Kodama
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001859:Bone Neoplasms / Q000188:drug therapy / Q000556:secondary*; D001932:Brain Neoplasms / Q000556:secondary*; D001943:Breast Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D003520:Cyclophosphamide / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D015409:Mastectomy, Radical; D008875:Middle Aged; D012878:Skin Neoplasms / Q000188:drug therapy / Q000556:secondary*; D013997:Time Factors
chemical_list: D004317:Doxorubicin; D003520:Cyclophosphamide; D005472:Fluorouracil