[Change in activity of microsomal cytochrome P-450-dependent monooxygenases from rat liver exposed to chronic low doses of radiation].
The activity changes of cytochrome P-450-dependent monooxygenases of hepatic microsomal fraction were studied in, experimental animals after prolonged application (1 month) of low radiation doses (0.258 mkl/kg). The obtained results show the increase in catalytic activities of main forms of cytochrome P-450, participating in steroid hydroxylation, as well as the decrease in total content of cytochrome P-450 in hepatic microsomal fraction and the lowering of its demethylase activity.
Zolotareva
T A
TA
Grishanova
A Iu
AIu
Guliaeva
L F
LF
Liakhovich
V V
VV
D000818:Animals; D002384:Catalysis; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D004307:Dose-Response Relationship, Radiation; D006900:Hydroxylation; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology / Q000528:radiation effects*; D051381:Rats; D017208:Rats, Wistar
D003577:Cytochrome P-450 Enzyme System