title: Cell polarity: par for the polar course.
abstract: The nematode PAR-1 gene is required for asymmetric cell divisions during development. Recently identified mammalian Par-1 homologues are kinases that phosphorylate microtubule-associated proteins; their overexpression disrupts the microtubule cytoskeleton, and alters cellular structure and organization.
authors.affiliation: Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, California 94305-5426, USA. wjnelson@leland.stanford.edu
authors.forename: W J
authors.initials: WJ
authors.lastname: Nelson
authors.forename: K K
authors.initials: KK
authors.lastname: Grindstaff
mesh_terms: D000818:Animals; D017173:Caenorhabditis elegans; D016764:Cell Polarity; D004268:DNA-Binding Proteins / Q000502:physiology*; D008954:Models, Biological; D029701:Saccharomyces cerevisiae Proteins; D014157:Transcription Factors / Q000502:physiology*
chemical_list: D004268:DNA-Binding Proteins; D029701:Saccharomyces cerevisiae Proteins; D014157:Transcription Factors; C086677:YAP1 protein, S cerevisiae