Activation of the type 2 adrenal steroid receptor can rescue granule cells from death during development.
To determine whether activation of the type 2 adrenal steroid receptor affects granule cell death in the developing dentate gyrus, we treated rat pups with the type 2 receptor agonist RU28362 and examined degenerating cells using terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick end labeling (TUNEL) and Nissl staining. RU28362 administration decreased the numbers of degenerating granule cells suggesting that type 2 receptor activation can rescue granule cells from degeneration.
Gould
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E
Laboratory of Neuroendocrinology, Rockefeller University, New York, NY 10021, USA. goulde@princeton.edu
Tanapat
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McEwen
B S
BS
D000305:Adrenal Cortex Hormones / Q000378:metabolism*; D000315:Adrenalectomy; D000732:Androstanols / Q000494:pharmacology; D000818:Animals; D017209:Apoptosis / Q000187:drug effects / Q000502:physiology; D018891:Dentate Gyrus / Q000166:cytology / Q000254:growth & development*; D005260:Female; D006651:Histocytochemistry; D009410:Nerve Degeneration / Q000187:drug effects / Q000502:physiology; D009474:Neurons / Q000187:drug effects; D011247:Pregnancy; D051381:Rats; D017207:Rats, Sprague-Dawley; D011987:Receptors, Steroid / Q000819:agonists / Q000378:metabolism*
D000305:Adrenal Cortex Hormones; D000732:Androstanols; D011987:Receptors, Steroid; C049154:11,17-dihydroxy-6-methyl-17-(1-propynyl)androsta-1,4,6-triene-3-one