title: The eosinophil granule proteins in serum, but not the oxidative metabolism of the blood eosinophils, are increased in cancer.
abstract: The eosinophil activity in patients with renal cell adenocarcinoma during treatment with interleukin-2 (IL-2) and interferon-alpha (IFN-alpha) was reduced when measured as zymosan-induced lucigenin-enhanced chemiluminescence (CL). Eosinophil cationic protein (ECP), eosinophil peroxidase (EPO) and eosinophil protein-X (EPX) were significantly elevated before and during treatment (P<0.001) when compared with the controls. ECP and EPO were unaffected by the treatment whereas it induced an increased EPX level compared with values measured before treatment (P<0.05). The propensity of eosinophils to secrete their granule proteins may reflect the fact that eosinophils in cancer patients have an enhanced capacity to kill cancer cells.
authors.affiliation: Department of Clinical Chemistry, University Hospital, Uppsala, Sweden.
authors.forename: A
authors.initials: A
authors.lastname: Trulson
authors.forename: S
authors.initials: S
authors.lastname: Nilsson
authors.forename: P
authors.initials: P
authors.lastname: Venge
mesh_terms: D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001798:Blood Proteins / Q000378:metabolism*; D002292:Carcinoma, Renal Cell / Q000097:blood* / Q000628:therapy; D047091:Eosinophil Granule Proteins; D047209:Eosinophil Peroxidase; D047208:Eosinophil-Derived Neurotoxin; D004804:Eosinophils / Q000378:metabolism*; D005260:Female; D006801:Humans; D018836:Inflammation Mediators / Q000627:therapeutic use*; D016898:Interferon-alpha / Q000627:therapeutic use; D007376:Interleukin-2 / Q000627:therapeutic use; D008163:Luminescent Measurements; D008297:Male; D008875:Middle Aged; D010544:Peroxidases / Q000378:metabolism*; D012260:Ribonucleases
chemical_list: D000970:Antineoplastic Agents; D001798:Blood Proteins; D047091:Eosinophil Granule Proteins; D018836:Inflammation Mediators; D016898:Interferon-alpha; D007376:Interleukin-2; D047209:Eosinophil Peroxidase; D010544:Peroxidases; D047208:Eosinophil-Derived Neurotoxin; D012260:Ribonucleases