From the monitoring of severe to a survey of mild adverse effects of current antihypertensive therapy: the hidden side of the iceberg. The Scientific Committee of the Italian Pharmacoepidemiology Survey on Antihypertensive Therapy.
One of the most important causes of the unsatisfactory results of antihypertensive therapy in current medical practice is the difficulty in evaluating individual tolerability to the various antihypertensive agents. The methods commonly used, i.e. assessment in controlled studies of limited duration, or notification to pharmacovigilance authorities, clearly underestimate the problem. In order to obtain more correct information on antihypertensive practice, an Italian pharmacoepidemiological study has recently been planned, and the results of a pilot phase of this study are reported here.
Zanchetti
A
A
Centro di Fisiologia Clinica e Ipertensione, University of Milan, Ospedale Maggiore, Milano, Italy.
Ambrosioni
E
E
Pessina
A
A
Trimarco
B
B
D000959:Antihypertensive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D016903:Drug Monitoring; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D007558:Italy; D017891:Pharmacoepidemiology / Q000379:methods; D010865:Pilot Projects; D011358:Product Surveillance, Postmarketing
D000959:Antihypertensive Agents