title: Regulation of aquaporin-2 water channel trafficking by vasopressin.
abstract: Vasopressin regulates water excretion from the kidney by increasing the osmotic water permeability of the renal collecting duct. The aquaporin-2 water channel has been demonstrated to be the target for this action of vasopressin. Recent studies have demonstrated that vasopressin, acting through cyclic AMP, triggers fusion of aquaporin-2-bearing vesicles with the apical plasma membrane of the collecting duct principal cells. The vesicle-targeting proteins synaptobrevin-2 and syntaxin-4 are proposed to play roles in this process.
authors.affiliation: Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892-0951, USA. knep@helix.nih.gov
authors.forename: M A
authors.initials: MA
authors.lastname: Knepper
authors.forename: T
authors.initials: T
authors.lastname: Inoue
mesh_terms: D000818:Animals; D051399:Aquaporin 2; D051403:Aquaporin 6; D020346:Aquaporins; D002462:Cell Membrane / Q000502:physiology; D000242:Cyclic AMP / Q000502:physiology; D007473:Ion Channels / Q000737:chemistry / Q000502:physiology*; D007685:Kidney Tubules, Collecting / Q000502:physiology*; D008561:Membrane Fusion; D008565:Membrane Proteins / Q000502:physiology; D008954:Models, Biological; D008961:Models, Structural; D050765:Qa-SNARE Proteins; D050683:R-SNARE Proteins; D050600:SNARE Proteins; D015398:Signal Transduction; D014667:Vasopressins / Q000502:physiology*; D033921:Vesicular Transport Proteins; D014882:Water-Electrolyte Balance
chemical_list: D051399:Aquaporin 2; D051403:Aquaporin 6; D020346:Aquaporins; D007473:Ion Channels; D008565:Membrane Proteins; D050765:Qa-SNARE Proteins; D050683:R-SNARE Proteins; D050600:SNARE Proteins; D033921:Vesicular Transport Proteins; D014667:Vasopressins; D000242:Cyclic AMP