[Lipid peroxidation as a toxic mode of action for lead and cadmium].
Recent studies have shown that lead and cadmium deplete glutathione and protein-bound sulfhydryl groups, resulting in the production of reactive oxygen species. As a consequence enhanced lipid peroxidation, DNA damage and altered calcium and sulfhydryl homeostasis occur. Lipid peroxidation is often discussed as a cause of metal-induced toxicity, although many other authors suggest a pivotal role of interaction with sensitive SH groups in determining cadmium and lead toxicity.
Skoczyńska
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Katedry i Kliniki Chorób Wewnetrznych i Zawodowych Akademii Medycznej we Wrocławiu.
D000818:Animals; D002104:Cadmium / Q000009:adverse effects / Q000633:toxicity*; D004249:DNA Damage; D005978:Glutathione / Q000187:drug effects; D006706:Homeostasis / Q000187:drug effects; D006801:Humans; D066298:In Vitro Techniques; D007854:Lead / Q000009:adverse effects / Q000633:toxicity*; D015227:Lipid Peroxidation / Q000187:drug effects*; D017382:Reactive Oxygen Species / Q000378:metabolism
D017382:Reactive Oxygen Species; D002104:Cadmium; D007854:Lead; D005978:Glutathione