title: Patients' profiles in end stage coronary artery disease. Indications for treatment with transmyocardial laser revascularisation.
abstract: There is a subgroup of patients with coronary artery disease who are refractory to the therapeutical methods so far applied. We report on 128 patients who fulfill this definition and have therefore undergone pure transmyocardial laser revascularisation (TMLR) or transmyocardial laser revascularisation in combination with coronary bypass surgery at our institution. The patients can be characterized by a long history of coronary artery disease with multiple revascularizing procedures, e.g. bypass surgery or percutaneous transluminal coronary angioplasty (PTCA), pronounced symptoms of coronary artery disease and chronic heart failure in the presence of markedly reduced left ventricular ejection fractions and intense antiischemic medical therapy. The patients were 62.2 +/- 9.8 (SD) years of age, in 89.9% of them at least one bypass operation and in 44.5% up to more than three percutaneous transluminal coronary angioplasties (PTCAs) had been performed prior to TMLR. There was a history of myocardial infarction in 90.7% of patients and 89.8% were in the Canadian Cardiovascular Society (CCS) classes III or IV and 94.5% of them were in the NYHA classes III or IV. The left ventricular ejection fraction was 49.5 +/- 16.4% and all of the patients were under intense antiischemic medical treatment which included nitrates or molsidomine in 96.9%, beta blockers in 53.1%, angiotensin converting enzyme inhibitors (ACE inhibitors) in 44.5%, digitalis in 22.7% and diuretics in 52.3% of patients. The preoperative data on myocardial viability, inducible ischemia and coronary morphology provided important clinical information for the decision, which revascularizing method would be the most appropriate for each vessel or myocardial region. This had to be weighed against the patient's operative risk, which is predominantly determined by the left ventricular ejection fraction, the arteriosclerotic involvement of the remaining vascular system and concomitant diseases, particularly of pulmonary origin.
authors.affiliation: Zentrum Innere Medizin-Schwerpunkt Kardiologie, Philipps-Universität Marburg.
authors.forename: R C
authors.initials: RC
authors.lastname: Funck
authors.forename: L
authors.initials: L
authors.lastname: Rybinski
authors.forename: H
authors.initials: H
authors.lastname: König
authors.forename: K
authors.initials: K
authors.lastname: Welzel
authors.forename: A
authors.initials: A
authors.lastname: Holland
authors.forename: K
authors.initials: K
authors.lastname: Ketteler
authors.forename: F
authors.initials: F
authors.lastname: Farokhzad
authors.forename: H
authors.initials: H
authors.lastname: Höffken
authors.forename: C
authors.initials: C
authors.lastname: Bethge
authors.forename: R
authors.initials: R
authors.lastname: Moosdorf
authors.forename: B
authors.initials: B
authors.lastname: Maisch
mesh_terms: D000368:Aged; D002303:Cardiac Output, Low / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D002908:Chronic Disease; D003327:Coronary Disease / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D003952:Diagnostic Imaging; D005260:Female; D006333:Heart Failure / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D053685:Laser Therapy / Q000295:instrumentation*; D008297:Male; D008875:Middle Aged; D009204:Myocardial Revascularization / Q000295:instrumentation*; D009206:Myocardium / Q000473:pathology; D018579:Patient Selection; D011379:Prognosis; D012008:Recurrence; D017211:Treatment Failure