title: Effect of growth hormone therapy on bone metabolism of growth hormone deficient children.
abstract: The effects of human growth hormone (hGH) therapy on biochemical markers of bone metabolism were studied in 17 children (10 boys and 7 girls, aged 3.7-13.1 years old) with idiopathic GH deficiency, before and 1 and 6 months after GH therapy (0.5 0.7 IU/kg weekly SC). Serum levels of calcium, phosphate, alkaline phosphatase osteocalcin, parathyroid hormone, 1,25 dihydroxyvitamin D, insulin-like growth factor I (IGF-I) and renal phosphate per 100 ml glomerular filtrate (TPO4/GFR) were assessed. During therapy with hGH a significant decrease of serum calcium levels and increases of phosphate, osteocalcin, parathyroid hormone 1,25 dihydroxyvitamin D and IGF-I were observed. TPO4/GFR was also significantly increased. Growth response (increment in HV) was positively related with changes in alkaline phosphatase and IGF-I levels after 6 months of hGH therapy. There was also a significant positive correlation between increment in HV and increment in TPO4/GFR after 1 month of GH therapy, whereas no correlation between HV and changes in osteocalcin levels was found.
  
  
  CONCLUSIONS
  GH treatment significantly influences mineral metabolism and the measurement of TPO4/ GFR after 1 month of GH therapy may serve as a useful predictor of growth response to hGH therapy in GH-deficient children.
authors.affiliation: Department of Paediatrics, Faculty of Nursing, University of Athens, Greece.
authors.forename: L
authors.initials: L
authors.lastname: Stamoyannou
authors.forename: F
authors.initials: F
authors.lastname: Karachaliou
authors.forename: E
authors.initials: E
authors.lastname: Gioureli
authors.forename: E
authors.initials: E
authors.lastname: Voskaki
authors.forename: C
authors.initials: C
authors.lastname: Mengreli
authors.forename: C S
authors.initials: CS
authors.lastname: Bartsocas
authors.forename: A
authors.initials: A
authors.lastname: Koutselinis
mesh_terms: D000293:Adolescent; D000704:Analysis of Variance; D001842:Bone and Bones / Q000378:metabolism*; D002118:Calcium / Q000097:blood / Q000652:urine; D002648:Child; D002675:Child, Preschool; D003404:Creatinine / Q000097:blood / Q000652:urine; D005260:Female; D005919:Glomerular Filtration Rate; D006130:Growth Disorders / Q000188:drug therapy* / Q000378:metabolism*; D019382:Human Growth Hormone / Q000172:deficiency* / Q000627:therapeutic use*; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D016014:Linear Models; D008297:Male; D008903:Minerals / Q000378:metabolism*; D015675:Osteocalcin / Q000097:blood; D010281:Parathyroid Hormone / Q000097:blood; D010710:Phosphates / Q000097:blood / Q000652:urine
chemical_list: D008903:Minerals; D010281:Parathyroid Hormone; D010710:Phosphates; D015675:Osteocalcin; D019382:Human Growth Hormone; D007334:Insulin-Like Growth Factor I; D003404:Creatinine; D002118:Calcium