Bacterial pathogenesis: a variation on variation in Lyme disease.
The discovery of antigenic variation in Borrelia burgdorferi, the bacterium that causes Lyme disease, provides a potential explanation for the chronic nature of infection as well as new insights into the genetic structure of highly recombinogenic loci responsible for combinatorial genetic diversification.
Koomey
M
M
Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, 48109 USA. mkoomey@umich.edu
D000940:Antigenic Variation; D015748:Borrelia burgdorferi Group / Q000235:genetics / Q000276:immunology* / Q000472:pathogenicity; D006801:Humans; D008193:Lyme Disease / Q000276:immunology / Q000382:microbiology*