title: Positive association between the GABRA5 gene and unipolar recurrent major depression.
abstract: The gamma-aminobutyric acid (GABA) neurotransmitter system has been implicated in the pathogenesis of mood disorders. To test this hypothesis we carried out an association study between a dinucleotide repeat polymorphism in the GABAA receptor alpha 5 subunit gene and bipolar and unipolar mood disorders. Our results suggest a possible involvement of this gene in unipolar but not in bipolar disorder.
authors.affiliation: Flanders Interuniversity Institute for Biotechnology, Born-Bunge Foundation, Department of Biochemistry, University of Antwerp, Belgium.
authors.forename: L
authors.initials: L
authors.lastname: Oruc
authors.forename: G R
authors.initials: GR
authors.lastname: Verheyen
authors.forename: I
authors.initials: I
authors.lastname: Furac
authors.forename: S
authors.initials: S
authors.lastname: Ivezić
authors.forename: M
authors.initials: M
authors.lastname: Jakovljević
authors.forename: P
authors.initials: P
authors.lastname: Raeymaekers
authors.forename: C
authors.initials: C
authors.lastname: Van Broeckhoven
mesh_terms: D000328:Adult; D000368:Aged; D001714:Bipolar Disorder / Q000235:genetics; D004247:DNA / Q000032:analysis; D003866:Depressive Disorder / Q000235:genetics*; D005260:Female; D008040:Genetic Linkage; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D011963:Receptors, GABA-A / Q000235:genetics*; D012008:Recurrence
chemical_list: D011963:Receptors, GABA-A; D004247:DNA