title: Evidence for association of HLA-A2 allele with onset age of Alzheimer's disease.
abstract: Our earlier studies had suggested a possible association between the HLA-A2 allele and Alzheimer's disease (AD). In the present study we tested the hypothesis that A2 is associated with earlier AD onset. We performed two independent studies: a collaborative study with 111 patients and a confirmatory study with 96 patients. We found similar patterns of reduced age at onset as a function of A2 in both data sets. Overall, A2 was associated with a significant 3-year shift to earlier onset. The effects of A2 and epsilon 4 on age at onset appeared additive. Our results suggest A2, or a closely linked gene, modulates onset age of AD. Association with A2 would suggest an immune/inflammatory response mechanism for AD.
authors.affiliation: Department of Molecular, Oregon Health Sciences University, Portland 97201, USA.
authors.forename: H
authors.initials: H
authors.lastname: Payami
authors.forename: G D
authors.initials: GD
authors.lastname: Schellenberg
authors.forename: S
authors.initials: S
authors.lastname: Zareparsi
authors.forename: J
authors.initials: J
authors.lastname: Kaye
authors.forename: G J
authors.initials: GJ
authors.lastname: Sexton
authors.forename: M A
authors.initials: MA
authors.lastname: Head
authors.forename: S S
authors.initials: SS
authors.lastname: Matsuyama
authors.forename: L F
authors.initials: LF
authors.lastname: Jarvik
authors.forename: B
authors.initials: B
authors.lastname: Miller
authors.forename: D Q
authors.initials: DQ
authors.lastname: McManus
authors.forename: T D
authors.initials: TD
authors.lastname: Bird
authors.forename: R
authors.initials: R
authors.lastname: Katzman
authors.forename: L
authors.initials: L
authors.lastname: Heston
authors.forename: D
authors.initials: D
authors.lastname: Norman
authors.forename: G W
authors.initials: GW
authors.lastname: Small
mesh_terms: D017668:Age of Onset; D000368:Aged; D000483:Alleles; D000544:Alzheimer Disease / Q000453:epidemiology / Q000235:genetics* / Q000276:immunology*; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics; D005260:Female; D005838:Genotype; D015789:HLA-A2 Antigen / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010641:Phenotype
chemical_list: D053327:Apolipoprotein E4; D001057:Apolipoproteins E; D015789:HLA-A2 Antigen