Gender and alcohol dosing: a procedure for producing comparable breath alcohol curves for men and women.
Gender differences in peak breath alcohol concentrations (BrACs) reached in alcohol administration studies can make the interpretation of study findings difficult. This study evaluated the CBAC computer program as a way of minimizing gender differences in the BrAC curve. After consuming a predrink meal that was adjusted by body mass, 31 female and 27 male subjects consumed an alcoholic beverage targeted for either 0.04% or 0.08%. Mean peak BrACs for women and men were not significantly different. Similarly, the four BrAC readings obtained over the first 2 hr postdrink showed no gender differences. A dose x gender interaction was observed on time to peak BrAC, with women reaching peak BrAC faster than men only in the high dose groups. By decreasing gender differences in BrAC curves, this dosing procedure can aid in reducing the potential confound of dose and gender.
Breslin
F C
FC
Addiction Research Foundation, Toronto, Ontario, Canada.
Kapur
B M
BM
Sobell
M B
MB
Cappell
H
H
D000328:Adult; D000435:Alcoholic Intoxication / Q000097:blood / Q000175:diagnosis*; D001944:Breath Tests; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D008297:Male; D012016:Reference Values; D012727:Sex Characteristics; D012984:Software
D000431:Ethanol