Effects of AMPA receptor positive modulators on amphetamine- and dizocilpine-induced locomotion.
Two allosteric alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor positive modulators, 1-(1,3-benzodioxol-5-ylcarbonyl)piperidine (1-BCP) and 1-(quinoxalin-6-ylcarbonyl)piperidine (CX516), and the antipsychotic drug, haloperidol, were tested for their ability to inhibit hyperactivity induced by amphetamine and dizocilpine in mice. Haloperidol (0.03-1.0 mg/kg) and 1-BCP (20.0-120.0 mg/kg) attenuated hyperactivity induced by both amphetamine and dizocilpine, with higher potency against amphetamine. CX516 (30.0-170.0 mg/kg), however, failed to attenuate amphetamine- and dizocilpine-induced hyperactivity up to a dose which decreased spontaneous locomotor activity. These results indicate that AMPA receptor positive modulators may not be uniform with regard to their effects on dopamine-mediated behaviors and their antipsychotic potential.
Vanover
K E
KE
Department of Pharmacology, CoCensys Inc., Irvine, CA 92618, USA. kim@rat.ucsd.edu
D000661:Amphetamine / Q000494:pharmacology*; D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology; D000697:Central Nervous System Stimulants / Q000494:pharmacology*; D004149:Dioxoles / Q000494:pharmacology; D016291:Dizocilpine Maleate / Q000494:pharmacology*; D018492:Dopamine Antagonists / Q000494:pharmacology; D018690:Excitatory Amino Acid Agonists / Q000494:pharmacology; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology*; D006220:Haloperidol / Q000494:pharmacology; D008124:Locomotion / Q000187:drug effects*; D008297:Male; D051379:Mice; D010880:Piperidines / Q000494:pharmacology; D018091:Receptors, AMPA / Q000378:metabolism*
C097396:1-(quinoxalin-6-ylcarbonyl)piperidine; D014150:Antipsychotic Agents; D000697:Central Nervous System Stimulants; D004149:Dioxoles; D018492:Dopamine Antagonists; D018690:Excitatory Amino Acid Agonists; D018691:Excitatory Amino Acid Antagonists; D010880:Piperidines; D018091:Receptors, AMPA; C085415:1-(1,3-benzodioxol-5-ylcarbonyl)piperidine; D016291:Dizocilpine Maleate; D000661:Amphetamine; D006220:Haloperidol