High serum levels of CA125 and interleukin-6 in a patient with Ki-1 lymphoma.
We report a 53-year-old-man with an aggressive Ki-1 lymphoma who had high serum CA125, a marker protein of the epithelial ovarian cancer, and interleukin-6 (IL-6) concentrations. Both CA125 and IL-6 levels decreased after chemotherapy and elevated with disease progression. The patient's lymphoma cells obtained before chemotherapy grew continuously in vitro, were IL-6 dependent and were found to secrete CA125 in culture medium. These results indicate that CA125 can be secreted by Ki-1 lymphoma cells and IL-6 may promote the growth of Ki-1 lymphoma cells.
Kubonishi
I
I
Department of Medicine, Kochi Medical School, Japan.
Bandobashi
K
K
Murata
N
N
Daibata
M
M
Ido
E
E
Sonobe
H
H
Ohtsuki
Y
Y
Miyoshi
I
I
D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D018394:CA-125 Antigen / Q000097:blood*; D003520:Cyclophosphamide / Q000627:therapeutic use; D004317:Doxorubicin / Q000627:therapeutic use; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D017728:Lymphoma, Large-Cell, Anaplastic / Q000188:drug therapy / Q000276:immunology*; D008297:Male; D011241:Prednisone / Q000627:therapeutic use; D014407:Tumor Cells, Cultured; D014750:Vincristine / Q000627:therapeutic use
D018394:CA-125 Antigen; D015850:Interleukin-6; D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011241:Prednisone