title: Oncogenic risk in a chemical plant: a methological approach and preliminary results.
abstract: One of the major problems that occupational medicine has to deal with is cancer risk assessment. Recent Italian legislation requires the evaluation of occupational exposure to carcinogens in all workplaces, but a standardized method to be used in the environmental and biological criteria is generally lacking. The objective of this report is to identify a multidisciplinary approach to the research on this topic. The study is based on a chemical plant that produces pitch. The multidisciplinary approach is based on risk- and health-damage assessments. Ethical aspects are also taken into account, and the research design incorporates an informed consent for all employees. Some preliminary results are available. From the environmental point of view, all parameters provide an airborne concentration value below threshold limit values (TLVs), but biological monitoring demonstrates an increased urinary excretion of 1-OH-pyrene in all tested subjects. In conclusion, the first objective of our study is to demonstrate the carcinogenic risk of employees, searching for an agreement between environmental analysis, biological monitoring, and health effect data. A close collaboration between different professions is necessary.
authors.affiliation: Occupational Health Service, Local Health Unit No. 6 of Leghorn, Tuscany, Italy.
authors.forename: A M
authors.initials: AM
authors.lastname: Loi
authors.forename: F
authors.initials: F
authors.lastname: Mariotti
authors.forename: L
authors.initials: L
authors.lastname: Turini
authors.forename: F
authors.initials: F
authors.lastname: Ottenga
authors.forename: A
authors.initials: A
authors.lastname: Cristaudo
authors.forename: A
authors.initials: A
authors.lastname: Vivaldi
authors.forename: T
authors.initials: T
authors.lastname: Davini
authors.forename: F
authors.initials: F
authors.lastname: Righini
authors.forename: E
authors.initials: E
authors.lastname: Chellini
mesh_terms: D000818:Animals; D001711:Biotransformation; D002617:Chemical Industry; D015331:Cohort Studies; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008297:Male; D051379:Mice; D009152:Mutagenicity Tests; D009153:Mutagens; D009369:Neoplasms / Q000139:chemically induced / Q000453:epidemiology*; D016273:Occupational Exposure; D018570:Risk Assessment; D012486:Salmonella typhimurium / Q000235:genetics
chemical_list: D009153:Mutagens