MRI as a method to reveal in-vivo pathology in MS.
Multiple sclerosis is primarily a disease of myelin. The degeneration of neurons and axons in MS has not been considered to be a major factor until recently. Magnetic resonance (MR) techniques have helped a great deal in describing the evolution of MS lesions over time. Some pathological and MR studies have shown that in the chronic stage of MS, axonal loss occurs. Further studies using MR techniques should help to understand this phenomenon as it occurs in vivo.
Paty
D W
DW
Division of Neurology, University of British Columbia, Vancouver, Canada.
D001921:Brain / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D009103:Multiple Sclerosis / Q000473:pathology* / Q000503:physiopathology; D009186:Myelin Sheath / Q000473:pathology