title: Relationship of visceral adipose tissue and glucose disposal is independent of sex in black NIDDM subjects.
abstract: To determine the interrelationship among insulin action, total or regional adiposity, and sex, we measured insulin-mediated glucose disposal by the euglycemic insulin clamp and adipose distribution using computed axial tomography (22 scans) in 32 black men and 20 black women with non-insulin-dependent diabetes mellitus (age 48 +/- 9 and 54 +/- 9 yr, body mass index 26.3 +/- 2.3 and 27.2 +/- 2.6 kg/m2, respectively). Women had approximately 80% more total and subcutaneous fat volume than men (31.8 +/- 8.3 vs. 18.6 +/- 6.1 and 28.5 +/- 7.3 vs. 14.7 +/- 4.6 liters) and less muscle volume (22.9 +/- 3.7 vs. 35.1 +/- 3.8 liters). Visceral fat volume did not differ between men and women (3.49 +/- 1.65 vs. 2.96 +/- 1.22 liters). Despite these body composition differences, an inverse nonlinear relationship existed between glucose disposal and visceral fat independent of sex (r = -0.58, P < 0.0001; men r = -0.60 and women r = -0.59; the slope and intercept were not different in men and women). Visceral fat explained a significant portion (34%) of variance in insulin-mediated glucose disposal, whereas total or subcutaneous fat and sex did not. Visceral fat appears to affect glucose disposal over a restricted range (up to approximately 2.5 l/m2 body surface area.
authors.affiliation: Department of Medicine, State University of New York Health Science Center at Brooklyn 11203, USA.
authors.forename: M A
authors.initials: MA
authors.lastname: Banerji
authors.forename: J
authors.initials: J
authors.lastname: Lebowitz
authors.forename: R L
authors.initials: RL
authors.lastname: Chaiken
authors.forename: D
authors.initials: D
authors.lastname: Gordon
authors.forename: J G
authors.initials: JG
authors.lastname: Kral
authors.forename: H E
authors.initials: HE
authors.lastname: Lebovitz
mesh_terms: D000273:Adipose Tissue / Q000473:pathology*; D000328:Adult; D044383:Black People; D001823:Body Composition; D003924:Diabetes Mellitus, Type 2 / Q000208:ethnology / Q000378:metabolism* / Q000473:pathology*; D005260:Female; D005947:Glucose / Q000378:metabolism*; D015309:Glucose Clamp Technique; D006801:Humans; D008297:Male; D008875:Middle Aged; D012727:Sex Characteristics; D014781:Viscera / Q000378:metabolism* / Q000473:pathology*
chemical_list: D005947:Glucose