[Clinicopathological study on early recurrent hepatoma and its treatment].
Early Recurrence of Hepatoma: PCNA Labeling Index and DNA Ploidy Pattern Sixty-four cases of recurrent hepatocellular carcinoma (HCC) after hepatectomy were divided into two groups; E-group with recurrence within one year, and L-group with recurrence after 1 year. Clinicopathological features and surgical curability were the same in both groups. E-group had significantly higher positive rates of portal invasion, intrahepatic metastasis and rate of patients with more than 40% on PCNA labeling index. While the similar recurrence mode and the same treatment modalities were done, cumulative survival rates after recurrence in E-group had a poorer prognosis than L-group. These results suggest the possibility of lower response for the treatment on the recurrent lesion would be manifest in the E-group. New modalities for prevention of early recurrence of HCC after resection should be developed.
Nakanishi
K
K
First Dept. of Surgery, Hokkaido University School of Medicine.
Une
Y
Y
Saiki
I
I
Haneda
T
T
Okubo
H
H
Tomioka
N
N
Shimamura
T
T
Kamiyama
T
T
Matsushita
M
M
D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000235:genetics / Q000473:pathology* / Q000628:therapy; D004273:DNA, Neoplasm / Q000235:genetics; D006498:Hepatectomy; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics / Q000473:pathology* / Q000628:therapy; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology*; D011003:Ploidies; D011184:Postoperative Period; D018809:Proliferating Cell Nuclear Antigen / Q000032:analysis
D004273:DNA, Neoplasm; D018809:Proliferating Cell Nuclear Antigen