Active-site studies of enzymes by secondary structure prediction and by molecular modeling.
Since the determination of the tertiary structure by X-ray crystallography has been achieved only for a limited number of proteins, alternative approaches are being sought. In this article, the use of secondary structure prediction and of molecular modeling is discussed. Several examples are analyzed in detail.
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Laboratorio de Biofísica Molecular, Facultad de Ciencias Biológicas, Universidad de Concepción, Chile.
Bunster
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D000595:Amino Acid Sequence; D000818:Animals; D004789:Enzyme Activation; D008958:Models, Molecular; D008969:Molecular Sequence Data; D017433:Protein Structure, Secondary; D014965:X-Rays