Small cell carcinoma of the prostate: a case report and review of the literature.
Primary small cell carcinoma of the prostate is rare. A case of primary small cell prostate cancer treated with radiation and chemotherapy is presented, and 33 previously published case reports are reviewed. Most of the patients (61%) had mixed tumors (small cell and adenocarcinoma) at diagnosis or had a history of adenocarcinoma of the prostate. Prostate specific antigen (PSA) data was available in 11 patients and was abnormal in 4 (36%). Once small cell carcinoma was diagnosed, 70% of patients had metastatic disease. Visceral metastases were common. Only one of seven patients responded to hormonal therapy, and two of eight patients responded to chemotherapy. Overall prognosis was poor.
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D001706:Biopsy; D018288:Carcinoma, Small Cell / Q000175:diagnosis* / Q000628:therapy; D003131:Combined Modality Therapy; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D017430:Prostate-Specific Antigen / Q000032:analysis; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000628:therapy; D014057:Tomography, X-Ray Computed
D017430:Prostate-Specific Antigen