title: Gingival squamous cell carcinoma in a patient with chronic graft-versus-host disease.
abstract: This article describes a gingival squamous cell carcinoma that developed in a 21-year-old woman who received a bone marrow transplant at the age of 16 from her human leukocyte antigen-identical sister as treatment for severe aplastic anemia. Thirty days after transplantation, she presented with cutaneous erythema as a result of acute graft-versus-host disease, and this subsequently evolved into chronic graft-versus-host disease. A lichenoid white plaque of the gingiva developed shortly thereafter, and it began to increase in size rapidly 4 years posttransplantation. Biopsy indicated squamous cell carcinoma arising in this region, apparently associated with chronic graft-versus-host disease. Few reports have described a secondary solid malignancy involving the oral cavity of young adults after bone marrow transplantation.
authors.affiliation: Department of Oral Surgery, School of Medicine, Chiba University.
authors.forename: H
authors.initials: H
authors.lastname: Otsubo
authors.forename: H
authors.initials: H
authors.lastname: Yokoe
authors.forename: T
authors.initials: T
authors.lastname: Miya
authors.forename: F
authors.initials: F
authors.lastname: Atsuta
authors.forename: N
authors.initials: N
authors.lastname: Miura
authors.forename: H
authors.initials: H
authors.lastname: Tanzawa
authors.forename: K
authors.initials: K
authors.lastname: Sato
mesh_terms: D000328:Adult; D000741:Anemia, Aplastic / Q000628:therapy; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D002294:Carcinoma, Squamous Cell / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D005260:Female; D005887:Gingival Neoplasms / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D006086:Graft vs Host Disease / Q000150:complications* / Q000209:etiology; D006801:Humans; D016609:Neoplasms, Second Primary / Q000209:etiology*