title: MR changes in the calcarine area resulting from retinal degeneration.
abstract: OBJECTIVE
  To study MR images for atrophic changes in the calcarine area resulting from retinal degeneration.
  
  
  METHODS
  MR images from nine patients with retinal degeneration confirmed by ophthalmologic examination and from 30 healthy volunteers were reviewed. The causes of retinal degeneration were hereditary pigmentary degeneration of the retina (four patients), high myopia (two patients), and chorioretinal atrophy (three patients); all patients had visual disturbances and visual field abnormalities. To estimate the morphological changes of the calcarine area, the widths of the right and left calcarine fissures were measured on T1-weighted sagittal images and compared with images from age-matched control subjects.
  
  
  RESULTS
  The calcarine fissures were significantly dilated in the patients with retinal degeneration. The anterior and middle points, which represent the peripheral visual field center, were more dilated than the posterior point.
  
  
  CONCLUSIONS
  The MR findings suggested calcarine atrophy related to retinal degeneration. Transneuronal degenerative changes may occur in the calcarine area after retinal degeneration.
authors.affiliation: Department of Radiology, Kumamoto University School of Medicine, Kumamoto City, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Kitajima
authors.forename: Y
authors.initials: Y
authors.lastname: Korogi
authors.forename: T
authors.initials: T
authors.lastname: Hirai
authors.forename: S
authors.initials: S
authors.lastname: Hamatake
authors.forename: I
authors.initials: I
authors.lastname: Ikushima
authors.forename: T
authors.initials: T
authors.lastname: Sugahara
authors.forename: Y
authors.initials: Y
authors.lastname: Shigematsu
authors.forename: M
authors.initials: M
authors.lastname: Takahashi
authors.forename: K
authors.initials: K
authors.lastname: Mukuno
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001284:Atrophy; D001931:Brain Mapping; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009410:Nerve Degeneration; D012162:Retinal Degeneration / Q000175:diagnosis* / Q000209:etiology; D014793:Visual Cortex / Q000473:pathology*; D014795:Visual Pathways / Q000473:pathology*