title: Islet cell tumour with vacuolated lipid-rich cytoplasm: a new histological variant of islet cell tumour.
abstract: OBJECTIVE
  A previously unreported clear cell variant of islet cell tumour of the pancreas is described.
  
  
  RESULTS
  By light microscopy, the cytoplasm of the clear cells was finely reticulated and vacuolated. Immuno-histochemical and electron microscopy studies confirmed the endocrine nature of the tumour.
  
  
  CONCLUSIONS
  The clear cell morphology was due to the accumulation of lipid in the cytoplasm.
authors.affiliation: University of Texas M.D. Anderson Cancer Centre, Houston 77030, USA.
authors.forename: N G
authors.initials: NG
authors.lastname: Ordóñez
authors.forename: E G
authors.initials: EG
authors.lastname: Silva
mesh_terms: D007516:Adenoma, Islet Cell / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure; D000328:Adult; D003593:Cytoplasm / Q000473:pathology; D003594:Cytoplasmic Granules / Q000473:pathology; D006801:Humans; D050356:Lipid Metabolism; D008297:Male; D008854:Microscopy, Electron; D010190:Pancreatic Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure