title: Beclomethasone dipropionate administration via cecostomy in ulcerative colitis.
abstract: Beclomethasone dipropionate was administered via a cecostomy to four patients with active ulcerative colitis that was refractory to conventional glucocorticosteroid therapy. From a tube cecostomy, beclomethasone dipropionate solution was administered continuously throughout the day. Clinical manifestations, laboratory examinations, and endoscopic and/or radiographic findings markedly improved within 1-2 wk. A serial decrease in the index of disease activity was observed from the time administration began (mean score, 226.0) to 2 wk later (137.4 points). An excellent clinical response was recognized without any significant side effects, and the urgent need for total colectomy was avoided in all four patients.
authors.affiliation: Department of Gastroenterology, Chikushi Hospital, Fukuoka University, Chikushino, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Matake
authors.forename: T
authors.initials: T
authors.lastname: Matsui
authors.forename: T
authors.initials: T
authors.lastname: Yao
authors.forename: T
authors.initials: T
authors.lastname: Sakurai
authors.forename: F
authors.initials: F
authors.lastname: Hirai
authors.forename: T
authors.initials: T
authors.lastname: Nagae
authors.forename: Y
authors.initials: Y
authors.lastname: Takaki
authors.forename: S
authors.initials: S
authors.lastname: Arima
authors.forename: T
authors.initials: T
authors.lastname: Imamura
mesh_terms: D000328:Adult; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D001507:Beclomethasone / Q000008:administration & dosage*; D002431:Cecostomy; D003093:Colitis, Ulcerative / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D000893:Anti-Inflammatory Agents; D001507:Beclomethasone