The demonstration of serum interleukin-8 and superoxide dismutase in Adamantiades-Behçet's disease.
Serum interleukin-8 (IL-8) production was measured in 43 Adamantiades-Behçet's disease (A-BD) patients and in 46 healthy volunteers using a sandwich enzyme-linked immunosorbent assay (ELISA). The mean serum IL-8 level of the patients (14.6 +/- 3 pg/ml) was significantly higher than that of controls (10.8 +/- 3 pg/ml, P < 0.05). Since IL-8 is known to have proinflammatory properties, it may play some role in the pathogenesis of A-BD. We also investigated the activity of serum superoxide dismutase (SOD) in the 43 patients with A-BD and in the 46 healthy volunteers. Serum SOD activity was markedly increased in the patients with A-BD (13.1 +/- 3%), especially in active A-BD, compared with that in the healthy volunteers (6.7 +/- 3%, P < 0.01). Our results suggest the involvement of IL-8 and SOD in the pathogenesis of A-BD as seen in other inflammatory diseases.
Wang
L M
LM
Department of Preventive Medicine, Tokyo Medical and Dental University, Japan.
Kitteringham
N
N
Mineshita
S
S
Wang
J Z
JZ
Nomura
Y
Y
Koike
Y
Y
Miyashita
E
E
D000328:Adult; D000368:Aged; D001528:Behcet Syndrome / Q000097:blood*; D005260:Female; D006801:Humans; D016209:Interleukin-8 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D013482:Superoxide Dismutase / Q000097:blood*
D016209:Interleukin-8; D013482:Superoxide Dismutase