title: Experimental animal studies on the hypoglycemic effects of a Copalchi extract.
abstract: The hypoglycemic effect of a Copalchi extract (Sucontral) was tested in 60 adult-male and female-Wistar rats in the present randomized, placebo-controlled, parallel-comparative animal study. A control group receiving only an Altromin standard chow was compared to treatment groups which received an Altromin chow enriched with Copalchi dry substance at 0.028% m/m or at 0.28% m/m. The study period was 30 days. The distinctly significant blood glucose lowering effect of the Copalchi extract could be demonstrated in both treatment groups. No significant difference in the antidiabetic effect was seen between the two concentrations. The onset of action of the Copalchi extract was observed between treatment day 1 and 3. A 20-25% decrease in the blood glucose concentration was achieved between the 7th and 15th day of treatment and remained at this level thereafter. This plateau was reached in the female rats already between treatment day 3 and 5. The parallel observed increase in the mean body weight was not striking and generally was the same between the test animals and the control animals.
authors.affiliation: Department of Pharmaceutical Sciences, University of Salerno, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Pinto
authors.forename: A
authors.initials: A
authors.lastname: Capasso
authors.forename: L
authors.initials: L
authors.lastname: Sorrentino
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005260:Female; D007004:Hypoglycemic Agents / Q000097:blood / Q000494:pharmacology*; D008297:Male; D019441:Plant Epidermis / Q000737:chemistry; D010936:Plant Extracts / Q000097:blood / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D010936:Plant Extracts