How to express an effect mean as percentage of a control mean?
The expression of effects as % of corresponding controls requires to consider the variance of these controls. Fieller's Theorem allows the appropriate calculation of the deviation of % values. The Zero-Method, which wrongly assumes that the variance of controls is zero, may lead to doubtful interpretations, as shown with experimental examples on the inhibition of depolarization-evoked transmitter release.
Feuerstein
T J
TJ
Sektion Klinische Neuropharmakologie der Neurologischen Universitätsklinik, Neurozentrum, Freiburg, Germany.
Rossner
R
R
Schumacher
M
M
D000109:Acetylcholine / Q000378:metabolism*; D000704:Analysis of Variance; D000818:Animals; D001921:Brain / Q000378:metabolism*; D006801:Humans; D015233:Models, Statistical; D011188:Potassium / Q000494:pharmacology; D051381:Rats; D016713:Ritanserin / Q000494:pharmacology; D012701:Serotonin / Q000494:pharmacology; D012702:Serotonin Antagonists / Q000494:pharmacology
D012702:Serotonin Antagonists; D016713:Ritanserin; D012701:Serotonin; D000109:Acetylcholine; D011188:Potassium