Assignment of the canalicular multispecific organic anion transporter gene (CMOAT) to human chromosome 10q24 and mouse chromosome 19D2 by fluorescent in situ hybridization.
Rabbit epithelial basolateral chloride conductance regulator (EBCR) and rat canalicular multispecific organic anion transporter (Cmoat) are found to be homologues based on protein sequence comparison and Northern blot analysis. EBCRis, therefore, renamed as rabbit Cmoat. The gene encoding CMOAT, a transporter possibly involved in Dubin-Johnson syndrome in humans, is mapped on human chromosome 10q24 and mouse chromosome 19D2.
van Kuijck
M A
MA
Department of Cell Physiology, University of Nijmengen, The Netherlands. m.vankuijclk@celfys.kun.nl
Kool
M
M
Merkx
G F
GF
Geurts van Kessel
A
A
Bindels
R J
RJ
Deen
P M
PM
van Os
C H
CH
D018528:ATP-Binding Cassette Transporters / Q000235:genetics; D000818:Animals; D027321:Anion Transport Proteins; D002352:Carrier Proteins / Q000235:genetics*; D002874:Chromosome Mapping; D002879:Chromosomes, Human, Pair 10 / Q000235:genetics* / Q000648:ultrastructure; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D017136:Ion Transport / Q000235:genetics; D007566:Jaundice, Chronic Idiopathic / Q000235:genetics; D051379:Mice / Q000235:genetics*; D008969:Molecular Sequence Data; D011817:Rabbits; D051381:Rats; D013045:Species Specificity
D018528:ATP-Binding Cassette Transporters; D027321:Anion Transport Proteins; D002352:Carrier Proteins; C099627:mrp2 protein, Oryctolagus cuniculus