A dose related response of 6-OHDA on chicken spectral sensitivity and oscillatory potentials of recording electroretinograms.
OBJECTIVE
To further study the contribution of dopamine system to the local growth controlling mechanisms, a dose related response of 6-hydroxydopamine (6-OHDA) was studied by recording electroretinograms (ERGs).


METHODS
The spectral sensitivity of the b-waves and spectral efficiency function of oscillatory potentials (OPs) including OP1, OP2 and OP3 in 4 different doses group were measured. The effect of ascorbate that must be contained in solution of 6-OHDA was first tested with the spectral sensitivity of the b-waves and a correlation between response of the OPs and age, as well as a difference in both own eyes was analyzed for determining an intra-subject and inter-subject variance.


RESULTS
An enhanced response was found in OP1, OP2 with doses of 175 micrograms and OP3 with dose of 150 micrograms, and the effect of OPs was mainly in wavelength from 620 nm to 480 nm. No significant increase was found in the spectral sensitivity of the b-waves. The dose 200 micrograms seemed to be toxic to the retina estimated by both spectral sensitivity of the b-waves and spectral efficiency function of the OPs.


CONCLUSIONS
The dose 175 micrograms and 150 micrograms of 6-OHDA yielded an effect on the chicken retina.
Li
X
X
Department of Ophthalmology, People's Hospital of Beijing Medical University.
Schaeffel
F
F
Konrad
K
K
Eberhart
Z
Z
D018663:Adrenergic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D002645:Chickens; D004305:Dose-Response Relationship, Drug; D004596:Electroretinography / Q000187:drug effects*; D009216:Myopia / Q000503:physiopathology*; D016627:Oxidopamine / Q000008:administration & dosage / Q000494:pharmacology*; D012815:Signal Processing, Computer-Assisted
D018663:Adrenergic Agents; D016627:Oxidopamine