title: In vitro drug susceptibility of Acanthamoeba castellani to chloroquine, ivermectin and fungizon.
abstract: In vitro sensitivity of Acanthamoeba castellani was tested to three drugs: Chloroquine, ivermectin and fungizone (amphotericin B). Sensitivity was demonstrated to the latter two compounds but not to chloroquine. Thus ivermectin and amphotericin B show promise as therapeutic agents against this parasite.
authors.affiliation: Biotechnology Centre, Institute for Medical Research, Jalan Pahang, Kuala Lumpur, Malaysia.
authors.forename: A N
authors.initials: AN
authors.lastname: Rain
authors.forename: T
authors.initials: T
authors.lastname: Radzan
authors.forename: S
authors.initials: S
authors.lastname: Sajiri
authors.forename: J W
authors.initials: JW
authors.lastname: Mak
mesh_terms: D000048:Acanthamoeba / Q000145:classification / Q000187:drug effects* / Q000254:growth & development; D000563:Amebicides / Q000494:pharmacology*; D000666:Amphotericin B / Q000494:pharmacology*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002738:Chloroquine / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D004351:Drug Resistance; D007559:Ivermectin / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D000563:Amebicides; D000900:Anti-Bacterial Agents; D007559:Ivermectin; D000666:Amphotericin B; D002738:Chloroquine