title: Effect of strenuous exercise on fibrinogen and fibrinolysis in healthy elderly men and women.
abstract: The elevated incidence of thrombotic disease in elderly people may be associated with an increase in PAI-1 and fibrinogen with ageing. Cross-sectional studies report an inverse relation of PAI-1 and fibrinogen with physical activity, but training studies show inconsistent results. In a controlled intervention study among elderly subjects (aged 60-80 years) we observed a moderate decrease in PAI-1 antigen (4%, -2.1 +/- 2.4 ng/ml), a significant increase in t-PA activity (11%, 0.07 +/- 0.04 IU/ml) and an unexpected significant increase in fibrinogen (6%, 0.18 +/- 0.07 g/l) in subjects following a 6-month intensive training program as compared to controls. Reduction in PAI-1 antigen was significantly associated with a decrease in triglycerides (beta = 10.3 ng/ml per 1 mM, p <0.01) and insulin (beta = 2.37 ng/ml per 1 mU/l, p = 0.07). Increase in fibrinogen coincided with a rise in C-reactive protein (p <0.001). These data suggest that regular intensive activity may increase fibrinolytic activity in a moderate way, but also may cause chronically elevated plasma levels of acute phase proteins in elderly persons.
authors.affiliation: Department of Epidemiology and Public Health, Agricultural University Wageningen, The Netherlands. Jantine.Schuit@medew.hegl.wau.nl
authors.forename: A J
authors.initials: AJ
authors.lastname: Schuit
authors.forename: E G
authors.initials: EG
authors.lastname: Schouten
authors.forename: C
authors.initials: C
authors.lastname: Kluft
authors.forename: M
authors.initials: M
authors.lastname: de Maat
authors.forename: P P
authors.initials: PP
authors.lastname: Menheere
authors.forename: F J
authors.initials: FJ
authors.lastname: Kok
mesh_terms: D000368:Aged / Q000502:physiology*; D000369:Aged, 80 and over; D001835:Body Weight; D015444:Exercise; D005260:Female; D005340:Fibrinogen / Q000032:analysis*; D005342:Fibrinolysis; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D005340:Fibrinogen