Serotonin, dopamine, and motor effects in Parkinson's disease.
We review recent reports suggesting that use of selective serotonergic agents that either inhibit synaptic reuptake or have specific serotonin receptor affinities may benefit a variety of motor disturbances in Parkinson's disease. The complex, mixed motoric effects of these agents in Parkinson's disease have not allowed for a consistent view on the interrelationship between dopamine and serotonin (5HT) in motor control but may speak to the nature of dysregulated neurotransmission in the disease.
Miyawaki
E
E
Department of Neurology, University of Kansas Medical Center, Kansas City 66160-7314, USA.
Meah
Y
Y
Koller
W C
WC
D000818:Animals; D004298:Dopamine / Q000502:physiology*; D006801:Humans; D009069:Movement Disorders / Q000188:drug therapy / Q000503:physiopathology*; D010300:Parkinson Disease / Q000188:drug therapy / Q000503:physiopathology*; D012701:Serotonin / Q000502:physiology*; D018490:Serotonin Agents / Q000009:adverse effects / Q000627:therapeutic use
D018490:Serotonin Agents; D012701:Serotonin; D004298:Dopamine