title: National trends in the mortality of children with sickle cell disease, 1968 through 1992.
abstract: OBJECTIVE
  This paper describes national trends in mortality of children with sickle cell disease and the settings in which death occurred.
  
  
  METHODS
  United States death certificate data from 1968 through 1992 were used to calculate mortality rates of Black children with sickle cell disease 1 to 14 years old. Deaths from trauma, congenital anomalies, and perinatal conditions were excluded.
  
  
  RESULTS
  Between 1968 and 1992, mortality rates of Black children with sickle cell disease decreased 41% for 1- to 4-year-olds, 47% for 5- to 9-year-olds, and 53% for 10- to 14-year-olds. During 1986 through 1992, children who died before hospital admission accounted for 41% of deaths among 1- to 4-year-olds, 27% among 5- to 9-year-olds, and 12% among 10- to 14-year-olds.
  
  
  CONCLUSIONS
  Survival of Black children with sickle cell disease has improved markedly since 1968. A substantial proportion of deaths continue to occur prior to hospital admission. Trends in sickle cell mortality can be monitored inexpensively with death-certificate data.
authors.affiliation: Office of International and Refugee Health, US Department of Health and Human Services, Rockville, Md, USA.
authors.forename: H
authors.initials: H
authors.lastname: Davis
authors.forename: K C
authors.initials: KC
authors.lastname: Schoendorf
authors.forename: P J
authors.initials: PJ
authors.lastname: Gergen
authors.forename: R M
authors.initials: RM
authors.lastname: Moore
mesh_terms: D000293:Adolescent; D001741:Black or African American / Q000706:statistics & numerical data; D017677:Age Distribution; D000755:Anemia, Sickle Cell / Q000401:mortality*; D002423:Cause of Death; D002648:Child; D002675:Child, Preschool; D003644:Death Certificates; D006450:Hemoglobin SC Disease / Q000401:mortality; D006801:Humans; D007223:Infant; D009026:Mortality / Q000639:trends; D014481:United States / Q000453:epidemiology