Using the international normalized ratio to standardize prothrombin time.
The international normalized ratio, or INR, was introduced in 1983 by the World Health Organization, or WHO, Committee on Biological Standards to more accurately assess patients receiving anticoagulation therapy. The INR mandates the universal standardization of prothrombin time. This article describes the method used to calculate INR, as well as its clinical relevance to the practice of dentistry.
Stern
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New York University/Bellevue Hospital Center, New York City, USA.
Karlis
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Kinney
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Glickman
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D000925:Anticoagulants / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D001777:Blood Coagulation / Q000187:drug effects; D002118:Calcium; D003729:Dental Care; D006207:Half-Life; D006493:Heparin / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use; D006801:Humans; D011517:Prothrombin Time; D012015:Reference Standards; D015203:Reproducibility of Results; D013923:Thromboembolism / Q000517:prevention & control; D013925:Thromboplastin; D013997:Time Factors; D014481:United States; D014859:Warfarin / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use; D014944:World Health Organization
D000925:Anticoagulants; D014859:Warfarin; D006493:Heparin; D013925:Thromboplastin; D002118:Calcium