[Steroidogenesis in rat testes in chronic alcoholic intoxication and addition of ethanol in vitro].
The influence of ethanol on steroid biosynthesis in microsomal fraction of rat testes has been studied. Addition of ethanol in vitro as well as chronic alcoholization have been shown to change the activity of enzymatic ensembles of steroidogenesis in testes. A significant decrease in 3 beta-hydroxysteroid dehydrogenase activity, revealed in all experiments, has permitted the authors to conclude that this phenomenon is of special significance for the realization of gonads hormonal response to ethanol.
Kashko
M F
MF
Khokha
A M
AM
D015096:3-Hydroxysteroid Dehydrogenases / Q000187:drug effects / Q000378:metabolism; D000311:Adrenal Glands / Q000187:drug effects / Q000378:metabolism; D000437:Alcoholism / Q000378:metabolism*; D000818:Animals; D004353:Drug Evaluation, Preclinical; D000431:Ethanol / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D008861:Microsomes / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D013256:Steroids / Q000096:biosynthesis*; D013737:Testis / Q000187:drug effects* / Q000378:metabolism
D013256:Steroids; D000431:Ethanol; D015096:3-Hydroxysteroid Dehydrogenases