A preliminary morphometric study on the endometrium from patients treated with indomethacin-releasing copper intrauterine device.
The intrauterine device (IUD) is an effective method of birth control. However, IUD-induced uterine bleeding is a major side-effect and always causes inconvenience, sometimes even anaemia. It has been reported that oral administration of indomethacin could can reduce IUD-induced uterine bleeding. In the present study, we investigated whether indomethacin-releasing copper IUD (IR-Cu-IUD) can prevent insertion-induced uterine bleeding and its mechanism. Nine healthy volunteers of reproductive age were selected for the study. Endometrial tissues were collected at same menstrual stage prior to and 3-6 months after IR-Cu-IUD insertion. Endometrial morphology, cell proliferation/differentiation, morphometry and activity of complement Factor VIII were examined. No significant difference was found in any of the parameters examined in the same patients, both prior to and after IR-Cu-IUD insertion. By comparison with data previously obtained from the patients who had Cu-IUD insertions, it is clear that IR-Cu-IUD markedly reduced IUD-induced uterine bleeding and this reduction is primarily contributed by the anti-inflammatory action of indomethacin.
Zhao
G
G
Pyong Yang Maternity Hospital, DPRK, Beijing, China.
Li
M
M
Zhu
P
P
Xu
R
R
Wang
J
J
Xu
R
R
D000328:Adult; D002454:Cell Differentiation; D002455:Cell Division; D004717:Endometrium / Q000737:chemistry / Q000166:cytology*; D005169:Factor VIII / Q000032:analysis; D005260:Female; D006801:Humans; D007213:Indomethacin / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D007435:Intrauterine Devices, Copper / Q000009:adverse effects*; D014592:Uterine Hemorrhage / Q000209:etiology* / Q000517:prevention & control*
D005169:Factor VIII; D007213:Indomethacin