Skin abnormality in aged fyn-/- fak+/- mice.
Focal adhesion kinase (FAK) is a novel non-receptor protein tyrosine kinase implicated in transducing signals from cell surface receptors. Its association with Fyn, a member of the Src family of tyrosine kinases, has been observed in cell lines. To examine in vivo the interaction between these two proteins, Fyn-deficient mice were bred with fak heterozygous mutants (Fak deficiency is embryonic lethal). A majority of animals with the double mutation (fyn-/- fak+/-) displayed a transient impairment in thymocyte development at four weeks of age. However, all of them developed skin abnormalities at the age of 8-12 months. The most prominent among abnormalities was a greatly increased number and size of sebaceous glands. Also, the epidermis was thickened and hyperkeratotic. These observations would suggest involvement of Fyn and FAK in keratinocyte differentiation.
Ilić
D
D
Department of Oncology, Institute of Medical Science, The University of Tokyo, Japan.
Kanazawa
S
S
Nishizumi
H
H
Aizawa
S
S
Kuroki
T
T
Mori
S
S
Yamamoto
T
T
D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D018791:CD4 Lymphocyte Count; D018414:CD8-Positive T-Lymphocytes; D015815:Cell Adhesion Molecules / Q000235:genetics / Q000502:physiology*; D002478:Cells, Cultured; D003433:Crosses, Genetic; D005260:Female; D051417:Focal Adhesion Kinase 1; D051416:Focal Adhesion Protein-Tyrosine Kinases; D018655:Lymphocyte Count; D008297:Male; D051379:Mice; D009154:Mutation; D011505:Protein-Tyrosine Kinases / Q000235:genetics / Q000502:physiology*; D011518:Proto-Oncogene Proteins / Q000235:genetics / Q000502:physiology*; D051076:Proto-Oncogene Proteins c-fyn; D012627:Sebaceous Glands / Q000473:pathology; D012737:Sex Factors; D012867:Skin / Q000473:pathology*; D012871:Skin Diseases / Q000235:genetics* / Q000473:pathology; D013950:Thymus Gland / Q000166:cytology; D014945:Wound Healing
D015815:Cell Adhesion Molecules; D011518:Proto-Oncogene Proteins; D011505:Protein-Tyrosine Kinases; D051417:Focal Adhesion Kinase 1; D051416:Focal Adhesion Protein-Tyrosine Kinases; C494960:Fyn protein, mouse; D051076:Proto-Oncogene Proteins c-fyn; C496051:Ptk2 protein, mouse