title: Effect of praziquantel and oxamniquine treatment on human isotype responses to Schistosoma mansoni: elevated IgE to adult worm.
abstract: Pre- and post-treatment antibody isotype responses to Schistosoma mansoni adult worm and soluble egg antigens were compared in a study population previously used to show that IgE against adult worm correlates negatively with intensity of reinfection following chemotherapeutic cure. IgG subclass responses to adult worm were lower after treatment whereas IgM and IgE were higher. The increase in IgE to adult worm was observed with different preparations of adult worm, including the worm tegument, and with both praziquantel and oxamniquine therapy. No significant difference was observed between pre- and post-treatment isotype responses to egg antigens following either praziquantel or oxamniquine therapy.
authors.affiliation: Department of Pathology, University of Cambridge, UK.
authors.forename: M
authors.initials: M
authors.lastname: Webster
authors.forename: P G
authors.initials: PG
authors.lastname: Fallon
authors.forename: A J
authors.initials: AJ
authors.lastname: Fulford
authors.forename: A E
authors.initials: AE
authors.lastname: Butterworth
authors.forename: J H
authors.initials: JH
authors.lastname: Ouma
authors.forename: G
authors.initials: G
authors.lastname: Kimani
authors.forename: D W
authors.initials: DW
authors.lastname: Dunne
mesh_terms: D000818:Animals; D000909:Antibodies, Helminth / Q000097:blood; D000947:Antigens, Helminth / Q000008:administration & dosage / Q000302:isolation & purification; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood*; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D010063:Ovum / Q000276:immunology; D010073:Oxamniquine / Q000008:administration & dosage / Q000627:therapeutic use*; D011223:Praziquantel / Q000008:administration & dosage / Q000627:therapeutic use*; D012550:Schistosoma mansoni / Q000254:growth & development / Q000276:immunology; D012555:Schistosomiasis mansoni / Q000188:drug therapy* / Q000276:immunology*; D012556:Schistosomicides / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D000909:Antibodies, Helminth; D000947:Antigens, Helminth; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D012556:Schistosomicides; D010073:Oxamniquine; D007073:Immunoglobulin E; D011223:Praziquantel