title: klumpfuss, a Drosophila gene encoding a member of the EGR family of transcription factors, is involved in bristle and leg development.
abstract: The klumpfuss (klu) transcription unit in Drosophila gives rise to two different transcripts of 4.5 and 4.9 kb, both of which encode a putative transcription factor with four zinc-finger motifs of the C2H2 class. Zinc-finger 2-4 are homologous to those of the proteins of the EGR transcription factor family. As in the case of the most divergent member of the family, the Wilms' tumor suppressor gene (WT-1), klu contains an additional zinc finger, which is only distantly related. Loss of klumpfuss function is semilethal and causes a variety of defects in bristles and legs of adults, as well as in mouth hooks and brains of larvae. Analysis of the mutants indicates that klumpfuss is required for proper specification and differentiation of a variety of cells, including the sensory organ mother cells and those of the distal parts of tarsal segments.
authors.affiliation: Institut für Entwicklungsbiologie, Universität zu Köln, Germany. thk@male.bio.cam.ac.uk
authors.forename: T
authors.initials: T
authors.lastname: Klein
authors.forename: J A
authors.initials: JA
authors.lastname: Campos-Ortega
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins; D002454:Cell Differentiation; D003001:Cloning, Molecular; D004247:DNA / Q000032:analysis; D004268:DNA-Binding Proteins / Q000235:genetics; D004330:Drosophila / Q000235:genetics* / Q000254:growth & development*; D029721:Drosophila Proteins; D004817:Epidermis / Q000254:growth & development; D005121:Extremities / Q000254:growth & development; D018507:Gene Expression Regulation, Developmental; D017344:Genes, Insect / Q000235:genetics*; D008969:Molecular Sequence Data; D009154:Mutation; D010641:Phenotype; D012333:RNA, Messenger / Q000032:analysis; D015183:Restriction Mapping; D017422:Sequence Analysis, DNA; D014157:Transcription Factors / Q000235:genetics* / Q000502:physiology; D016335:Zinc Fingers
chemical_list: D051792:Basic Helix-Loop-Helix Proteins; D004247:DNA; D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; D012333:RNA, Messenger; D014157:Transcription Factors; C107732:Klu protein, Drosophila; C089199:ac protein, Drosophila; C089197:sc protein, Drosophila