title: Mapping of the gene encoding the B56 beta subunit of protein phosphatase 2A (PPP2R5B) to a 0.5-Mb region of chromosome 11q13 and its exclusion as a candidate gene for multiple endocrine neoplasia type 1 (MEN1).
abstract: The multiple endocrine neoplasia type 1 (MEN1) locus has been previously localised to 11q13 by combined tumour deletion mapping and recombination studies, and a 0.5-Mb region, flanked by PYGM and D11S449, has been defined. In the course of constructing a conting, we have identified the location of the gene encoding the B56 beta subunit of protein phosphatase 2A (PP2A), which is involved in cell signal transduction pathways and thus represents a candidate gene for MEN1. We have searched for mutations in the PP2A-B56 beta coding region, together with the 5' and 3' untranslated regions in six MEN1 patients. DNA sequence abnormalities were not identified and thus the PP2A-B56 beta gene is excluded as the candidate gene for MEN1. However, our precise localisation of PP2A-B56 beta to this region of 11q13 may help in elucidating the basis for other disease genes mapping to this generich region.
authors.affiliation: MRC Molecular Endocrinology Group, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK.
authors.forename: S A
authors.initials: SA
authors.lastname: Forbes
authors.forename: A A
authors.initials: AA
authors.lastname: Pannett
authors.forename: J H
authors.initials: JH
authors.lastname: Bassett
authors.forename: B
authors.initials: B
authors.lastname: Harding
authors.forename: C
authors.initials: C
authors.lastname: Wooding
authors.forename: R V
authors.initials: RV
authors.lastname: Thakker
authors.forename: R
authors.initials: R
authors.lastname: Butler
authors.forename: D
authors.initials: D
authors.lastname: Ogilvie
authors.forename: R
authors.initials: R
authors.lastname: Anand
authors.forename: P
authors.initials: P
authors.lastname: Gaudray
authors.forename: G
authors.initials: G
authors.lastname: Weber
authors.forename: C
authors.initials: C
authors.lastname: Larsson
authors.forename: C X
authors.initials: CX
authors.lastname: Zhang
authors.forename: A
authors.initials: A
authors.lastname: Calender
authors.forename: J W
authors.initials: JW
authors.lastname: Höppener
authors.forename: C J
authors.initials: CJ
authors.lastname: Lips
authors.forename: K
authors.initials: K
authors.lastname: Kas
mesh_terms: D002874:Chromosome Mapping; D018244:Chromosomes, Artificial, Yeast; D002880:Chromosomes, Human, Pair 11; D015723:Gene Library; D006801:Humans; D018761:Multiple Endocrine Neoplasia Type 1 / Q000235:genetics*; D009363:Neoplasm Proteins / Q000235:genetics*; D010749:Phosphoprotein Phosphatases / Q000235:genetics*; D054648:Protein Phosphatase 2; D011518:Proto-Oncogene Proteins
chemical_list: C105373:MEN1 protein, human; D009363:Neoplasm Proteins; D011518:Proto-Oncogene Proteins; D010749:Phosphoprotein Phosphatases; D054648:Protein Phosphatase 2