[Investigation of infiltrating lymphocytes and immunoglobulin by immunohistochemical method in cheilitis granulomatosa].
Category and distribution of infiltrating lymphocytes and immunoglobulin in 12 cases with cheilitis granulomatosa (CG) and 4 cases with Melkersson-Rosenthal syndrome (MRS) were investigated. The result was that infiltration of lymphocytes in granulomatous type was more severe than that in interstitial inflammtion type. Infiltrators mainly consisted of T helper lymphocytes and immunoglobulin was IgM. It was considered that local immunoreaction was enhanced suggesting that cyto-immunity was a dominant factor with participation of humoral immunity. The result will be helpful to elucidate the pathogeneses and the function of many immuno-factors in the CG. It helps to understand the clinical manifestations and may be a theoretic reference for seeking immuno-modulation for treatment.
Liu
H
H
Department of pathology, Beijing Institute of Otorhinolaryngology.
Han
D
D
Zheng
L
L
D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis*; D007150:Immunohistochemistry; D008556:Melkersson-Rosenthal Syndrome / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*
D007074:Immunoglobulin G