[Mutagen-modifying effects of beta-carotene in vivo].
A chromosome aberration test on bone marrow cells of C57B1/6 mice showed that beta-carotene (BC) applied by oral administration as a E160a food dye (30% oil suspension) at doses of 0.5, 5, and 50 mg/kg simultaneously with cyclophosphamide (CPA) and dioxidine (DN) injected intraperitoneally for a period of 24 h did not modify their clastogenic effects. If the animals were pretreated with perorally administrated beta-carotene dye at doses of 5 and 50 mg/kg (corresponding to 1.5 and 15 mg/kg of BC) for 5 consecutive days, a statistically significant reduction in the clastogenic effect of the DN injected for 24 h but not the CPA was observed. In another set of experiments, E160a and clastogens were administered simultaneously for 5 consecutive days, and the animals were killed 6 h after the last treatment. In this case, BC at the dose of 0.15-15 mg/kg statistically significantly reduced the clastogenicity of DN at all doses used, and of CPA at doses of 1.5 and 15 mg/kg.
Durnev
A D
AD
Tiurina
L S
LS
Guseva
N V
NV
Oreshchenko
A V
AV
Seredenin
S B
SB
D000818:Animals; D016587:Antimutagenic Agents / Q000494:pharmacology*; D002869:Chromosome Aberrations; D003520:Cyclophosphamide / Q000633:toxicity; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009153:Mutagens / Q000737:chemistry / Q000633:toxicity*; D011810:Quinoxalines / Q000633:toxicity; D019207:beta Carotene / Q000494:pharmacology*
D016587:Antimutagenic Agents; D009153:Mutagens; D011810:Quinoxalines; D019207:beta Carotene; C001077:dioxidine; D003520:Cyclophosphamide