title: [The role of urokinase type plasminogen activator in invasion of bile duct carcinoma].
abstract: OBJECTIVE
  To study the role of urokinase type plasminogen activator (u-PA) in the invasive process of bile duct carcinoma.
  
  
  METHODS
  The secretion of u-PA and the invasive potential of tumor cell in vitro in a newly established cell line of bile duct carcinoma, QBC939, were observed by using an amnion invasion culture system.
  
  
  RESULTS
  QBC939 cells secreted u-PA with high invasive potential. The inhibitors of u-PA and plasmin, tranexamic acid and 6-aminocaproic acid, obviously inhibited the u-PA activity and the invasive potential of QBC939 cells.
  
  
  CONCLUSIONS
  u-PA is one of the important enzymes in tumor invasion. Inhibiting u-PA or plasmin may be a prospective therapy for tumor treatment.
authors.affiliation: Center of Hepatobiliary Surgery, Southwest Hospital, Chongqing.
authors.forename: S
authors.initials: S
authors.lastname: Wang
authors.forename: B
authors.initials: B
authors.lastname: Han
authors.forename: H
authors.initials: H
authors.lastname: Duan
mesh_terms: D001650:Bile Duct Neoplasms / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D014407:Tumor Cells, Cultured; D014568:Urokinase-Type Plasminogen Activator / Q000502:physiology*
chemical_list: D014568:Urokinase-Type Plasminogen Activator