title: Coenzyme Q changes in liver and plasma in the rat after partial hepatectomy.
abstract: The levels of coenzyme Q were determined in blood plasma and regenerating liver mitochondria of hepatectomized rats, using as controls either sham-operated or non-operated animals. Mitochondrial CoQ9 content increased in sham-operated rats, whereas it was significantly lower in hepatectomized with respect to non-operated animals. Plasma CoQ9 levels decreased dramatically in hepatectomized animals, but increased strongly in sham-operated in comparison with non-operated rats. The data suggest the possibility of a rate-limiting step in CoQ biosynthesis in hepatectomized animals.
authors.affiliation: Department of Biochemistry G. Moruzzi, University of Bologna, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Castelluccio
authors.forename: G
authors.initials: G
authors.lastname: Formiggini
authors.forename: M
authors.initials: M
authors.lastname: Merlo Pich
authors.forename: M L
authors.initials: ML
authors.lastname: Genova
authors.forename: C
authors.initials: C
authors.lastname: Bovina
authors.forename: M
authors.initials: M
authors.lastname: Marchetti
authors.forename: G
authors.initials: G
authors.lastname: Lenaz
mesh_terms: D000818:Animals; D006498:Hepatectomy; D008074:Lipoproteins / Q000378:metabolism; D008115:Liver Regeneration; D008297:Male; D008930:Mitochondria, Liver / Q000378:metabolism*; D011184:Postoperative Period; D051381:Rats; D017208:Rats, Wistar; D014451:Ubiquinone / Q000097:blood / Q000378:metabolism*
chemical_list: D008074:Lipoproteins; D014451:Ubiquinone; C030571:ubiquinone 9