Immunohistopathological characterization of pig pneumonia caused by a combined Aujeszky's disease virus and Actinobacillus pleuropneumoniae infection.
Nine pigs were inoculated endobronchially with Actinobacillus pleuropneumoniae serotype 1 (App-1) 6 days after infection with Aujeszky's disease virus (ADV); four died within 3 days and the remainder were killed after 1-6 days. Immunohistopathologically, there were two types of pneumonic lesion: pleuropneumonia, characterized by coagulative necrosis, oedema and fibrinous thrombosis; and necrotizing interstitial pneumonia, characterized by bronchitis, bronchiolitis and alveolitis. The former type of lesion was associated with App-1 antigen, and the latter with ADV antigen. These results indicated that a combined ADV and App-1 infection produced severe haemorrhagic pleuropneumonia; and that ADV and App-1 each produced a characteristic pneumonic lesion.
Narita
M
M
National Institute of Animal Health, Ministry of Agriculture, Forestry and Fisheries, Ibaraki, Japan.
Kawashima
K
K
Nakagawa
H
H
Uchimura
A
A
Ohashi
T
T
Kimura
K
K
Tanimura
N
N
D016977:Actinobacillus pleuropneumoniae / Q000302:isolation & purification / Q000472:pathogenicity; D000818:Animals; D000942:Antigens, Bacterial / Q000032:analysis; D000956:Antigens, Viral / Q000032:analysis; D001980:Bronchi / Q000473:pathology; D004731:Endotoxins / Q000032:analysis; D011558:Herpesvirus 1, Suid / Q000302:isolation & purification / Q000472:pathogenicity; D008168:Lung / Q000473:pathology; D018410:Pneumonia, Bacterial / Q000382:microbiology / Q000473:pathology / Q000662:veterinary*; D011024:Pneumonia, Viral / Q000473:pathology / Q000662:veterinary* / Q000821:virology; D013552:Swine; D013553:Swine Diseases / Q000382:microbiology / Q000473:pathology / Q000821:virology; D014132:Trachea / Q000473:pathology
D000942:Antigens, Bacterial; D000956:Antigens, Viral; D004731:Endotoxins