Jennisseensosides C and D, biologically active acylated triterpene saponins from Silene jenisseensis.
We previously reported the isolation and structure elucidation of a new trans-p-methoxycinnamoyl triterpene-saponin along with its cis-p-methoxycinnamoyl isomer as an inseparable mixture from the roots of Silene jenisseensis. In a continuing study on this plant, two additional new acylated triterpene-saponins were obtained as an inseparable mixture. Their structures have been established by chemical means and spectroscopic methods including 1D and 2D homonuclear and heteronuclear correlation NMR spectroscopy as 3-O-[beta-D-galactopyranosyl-(1-->2)-beta-D-glucuronopyranosyl]-28 -O-[{alpha-L-rhamnopyranosyl-(1-->2)}-{4-O-trans-p-methoxycinnamoyl++ +}-beta-D-fucopyranosyl] quillaic acid and its cis-isomer, respectively. They showed a significant enhancement of the granulocyte phagocytosis in vitro.
Lacaille-Dubois
M A
MA
Laboratoire de Pharmacognosie, Université de Bourgogne, Dijon, France.
Hanquet
B
B
Cui
Z H
ZH
Lou
Z C
ZC
Wagner
H
H
D002236:Carbohydrate Conformation; D002240:Carbohydrate Sequence; D004365:Drugs, Chinese Herbal; D006801:Humans; D008213:Lymphocyte Activation; D009682:Magnetic Resonance Spectroscopy; D008969:Molecular Sequence Data; D015394:Molecular Structure; D009828:Oleanolic Acid / Q000031:analogs & derivatives*; D010587:Phagocytosis / Q000187:drug effects; D012503:Saponins / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
D004365:Drugs, Chinese Herbal; D012503:Saponins; D014315:Triterpenes; C107206:jenisseensoside C; C107207:jenisseensoside D; D009828:Oleanolic Acid