title: On the origin and frequency of Y chromosome deletions responsible for severe male infertility.
abstract: The origin of deletions associated with non-obstructive severe oligozoospermia in men are discussed. Deletions could arise during various stages of meiosis, at later stages in spermatids, or post-fertilization. Certain embryonic stages may be highly sensitive. The possibilities of an inherited propensity to these and other deletions, and of mosaicism in embryos are assessed.
authors.affiliation: Churchill College, Cambridge, UK.
authors.forename: R G
authors.initials: RG
authors.lastname: Edwards
authors.forename: C E
authors.initials: CE
authors.lastname: Bishop
mesh_terms: D002872:Chromosome Deletion; D006801:Humans; D008297:Male; D009845:Oligospermia / Q000235:genetics*; D014998:Y Chromosome / Q000235:genetics*