title: [Study on coagulation fibrinolytic systems in predialysis patients with chronic renal failure--comparison between patients with chronic glomerulonephritis and patients with diabetic nephropathy].
abstract: To clarify the abnormalities of coagulation and fibrinolytic systems on predialysis patients with chronic renal failure, we measured indices of coagulation and fibrinolytic systems in 33 predialysis patients whose creatinine (Cr) levels were over 3.0 mg/dl. We termed twenty-four patients with chronic glomerulonephritis the "CGN group". We also termed nine patients wit diabetes mellitus the "DM group". We measured thrombin.antithrombin III complex (TAT), alpha 2-plasmin inhibitor plasmin complex (PIC), D-dimer, protein C, protein S, thrombomodulin (TM), vitronectin, tissue plasminogen activator.plasminogen activator inhibitor-1 complex (tPAI-C) in theses two groups. Furthermore, we measured the same indices after 6 months in the CGN group. As a result, the plasma levels of both TAT, PIC, TM/Cr ration in the DM group were significantly higher that those in the CGN group, changes in both protein S activities and plasma levels of tPAI-C were reduced significantly after 6 months. In conclusion, the abnormalities of coagulation and fibrinolytic systems in predialysis diabetic patients were stronger than those in predialysis patients with CGN. Furthermore, these abnormalities were worsened after 6 months in predialysis patients with chronic renal failure.
authors.affiliation: Department of Internal Medicine III, Okayama University Medical School, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Nagake
authors.forename: H
authors.initials: H
authors.lastname: Makino
authors.forename: N
authors.initials: N
authors.lastname: Yorioka
authors.forename: S
authors.initials: S
authors.lastname: Nomura
authors.forename: G
authors.initials: G
authors.lastname: Osawa
authors.forename: M
authors.initials: M
authors.lastname: Yamakido
authors.forename: H
authors.initials: H
authors.lastname: Kawasaki
authors.forename: Y
authors.initials: Y
authors.lastname: Kato
authors.forename: M
authors.initials: M
authors.lastname: Matsuzaki
authors.forename: K
authors.initials: K
authors.lastname: Shikata
authors.forename: J
authors.initials: J
authors.lastname: Uemasu
authors.forename: H
authors.initials: H
authors.lastname: Somiya
authors.forename: Z
authors.initials: Z
authors.lastname: Fujii
authors.forename: S
authors.initials: S
authors.lastname: Hayashida
authors.forename: T
authors.initials: T
authors.lastname: Nasu
authors.forename: Y
authors.initials: Y
authors.lastname: Oyabu
authors.forename: Y
authors.initials: Y
authors.lastname: Nitta
authors.forename: H
authors.initials: H
authors.lastname: Kawanishi
authors.forename: K
authors.initials: K
authors.lastname: Usui
authors.forename: K
authors.initials: K
authors.lastname: Fujiwara
authors.forename: N
authors.initials: N
authors.lastname: Takasugi
authors.forename: K
authors.initials: K
authors.lastname: Kanehara
authors.forename: N
authors.initials: N
authors.lastname: Hamaguchi
authors.forename: I
authors.initials: I
authors.lastname: Kumagai
authors.forename: Z
authors.initials: Z
authors.lastname: Ota
mesh_terms: D000328:Adult; D000368:Aged; D000933:Antifibrinolytic Agents / Q000032:analysis; D000990:Antithrombin III / Q000032:analysis; D001777:Blood Coagulation; D002908:Chronic Disease; D003928:Diabetic Nephropathies / Q000097:blood*; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis; D005341:Fibrinolysin / Q000032:analysis; D005342:Fibrinolysis; D005921:Glomerulonephritis / Q000097:blood*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010447:Peptide Hydrolases / Q000032:analysis; D011486:Protein C / Q000032:analysis; D017293:Protein S / Q000032:analysis; D000979:alpha-2-Antiplasmin
chemical_list: D000933:Antifibrinolytic Agents; D005338:Fibrin Fibrinogen Degradation Products; D011486:Protein C; D017293:Protein S; D000979:alpha-2-Antiplasmin; C046193:antithrombin III-protease complex; C036309:fibrin fragment D; C037742:plasmin-plasmin inhibitor complex; D000990:Antithrombin III; D010447:Peptide Hydrolases; D005341:Fibrinolysin