Synaptic plasticity in olfactory memory formation in female mice.
Female mice develop a long-lasting olfactory recognition memory of a partner male at the first relay in the vomeronasal system. In this study the synaptic plasticity relevant to this phenomenon was examined at reciprocal dendrodendritic synapses in the accessory olfactory bulb of female mice by electron microscopy. The size of asymmetrical excitatory synapses (mitral/tufted to granule cells) of the reciprocal synapses was significantly larger in the group of female mice which were subjected to a treatment intended to induce olfactory memory formation than in the control group. It is suggested that olfactory memory formation is associated with a conformational change at the level of synaptic structure of the accessory olfactory bulb.
Matsuoka
M
M
Laboratory of Veterinary Ethology, University of Tokyo, Japan.
Kaba
H
H
Mori
Y
Y
Ichikawa
M
M
D000704:Analysis of Variance; D000818:Animals; D003712:Dendrites / Q000502:physiology / Q000648:ultrastructure; D004971:Estrus; D005260:Female; D008297:Male; D008568:Memory / Q000502:physiology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008854:Microscopy, Electron; D009473:Neuronal Plasticity; D009830:Olfactory Bulb / Q000502:physiology* / Q000648:ultrastructure; D012726:Sexual Behavior, Animal; D012903:Smell / Q000502:physiology*; D013569:Synapses / Q000502:physiology* / Q000648:ultrastructure*