title: [The changes of plasma nitric oxide in patients with pregnancy induced hypertension].
abstract: OBJECTIVE
  To determine whether the antepartum and postpartum plasma nitric oxide (NO) levels were changed in pregnancy induced hypertension (PIH).
  
  
  METHODS
  30 patients with PIH and 30 healthy women in their late pregnancy were studied. The antepartum and postpartum plasma NO2-/NO2- levels, the stable metabolic end products of NO, and cyclic guanosine monophosphate (cGMP) were measured with greiss reagent.
  
  
  RESULTS
  (1) The plasma concentration of NO2-/NO2- and cGMP in patients with PIH decreased significantly when compared with that of healthy pregnant women (P < 0.01). (2) The concentration of antepartum plasma NO2-/NO2- was markedly lower than that of postpartum one in PIH patients (P < 0.01). (3) There was a negative correlation between the plasma NO2-/NO3- level and systolic blood pressure in PIH (P < 0.01). (4) A positive correlation was seen between plasma NO2-/NO3- levels and cGMP levels in PIH patients (P < 0.01).
  
  
  CONCLUSIONS
  The decrease of NO synthesis may be one of the important factors responsible for PIH.
authors.affiliation: Research Institute of Surgery, Daping Hospital, Third Military Medical University, Chongqing.
authors.forename: L
authors.initials: L
authors.lastname: Li
authors.forename: Z
authors.initials: Z
authors.lastname: Chen
authors.forename: Y
authors.initials: Y
authors.lastname: Xu
mesh_terms: D000328:Adult; D006152:Cyclic GMP / Q000097:blood; D005260:Female; D006801:Humans; D009569:Nitric Oxide / Q000097:blood*; D019001:Nitric Oxide Synthase / Q000378:metabolism*; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy
chemical_list: D009569:Nitric Oxide; D019001:Nitric Oxide Synthase; D006152:Cyclic GMP