Regulation of parathyroid cell proliferation.
The parathyroid normally has very few cells in mitosis but it retains the potential to proliferate. In-vivo studies in rats have demonstrated that hypocalcaemia and high serum phosphate both lead to an increase in the number of proliferating cells, which is relevant to the increased parathyroid cell proliferation in chronic renal failure. Hypophosphataemia and 1,25(OH)2D3 decrease parathyroid cell proliferation. Genetic factors have been defined for multiple endocrine neoplasia which includes parathyroid cell hyperplasia, and in some parathyroid adenomas there are genetic rearrangements.
Silver
J
J
Minerva Center for Calcium and Bone Metabolism, Hadassah University Hospital, Jerusalem, Israel.
Sela
S B
SB
Naveh-Many
T
T
D000236:Adenoma / Q000235:genetics; D000818:Animals; D002117:Calcitriol / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D005838:Genotype; D006801:Humans; D006961:Hyperparathyroidism / Q000209:etiology / Q000235:genetics / Q000378:metabolism; D006965:Hyperplasia; D006996:Hypocalcemia / Q000473:pathology; D017674:Hypophosphatemia / Q000473:pathology; D066298:In Vitro Techniques; D007676:Kidney Failure, Chronic / Q000473:pathology; D009377:Multiple Endocrine Neoplasia / Q000473:pathology; D010280:Parathyroid Glands / Q000166:cytology* / Q000187:drug effects / Q000473:pathology; D010282:Parathyroid Neoplasms / Q000235:genetics; D010710:Phosphates / Q000097:blood; D051381:Rats; D018167:Receptors, Calcitriol / Q000235:genetics; D044169:Receptors, Calcium-Sensing; D011956:Receptors, Cell Surface / Q000378:metabolism
D010710:Phosphates; D018167:Receptors, Calcitriol; D044169:Receptors, Calcium-Sensing; D011956:Receptors, Cell Surface; C473605:extracellular calcium cation-sensing receptor, rat; D002117:Calcitriol