Xenobiotic-induced hepatotoxicity: mechanisms of liver injury and methods of monitoring hepatic function.
Xenobiotic-induced liver injury is a clinically important etiology of hepatic disease that, if not recognized, can lead to hepatic failure. In this article we discuss the mechanisms of xenobiotic-induced liver injury, various factors that can alter the risk and severity of injury, the clinical and laboratory manifestations of injury, and the methods used to detect the presence of injury and (or) functioning liver mass.
Sturgill
M G
MG
Department of Pharmacy Practice and Administration, Rutgers University College of Pharmacy, Piscataway, NJ 08855-0789, USA.
Lambert
G H
GH
D000818:Animals; D001711:Biotransformation; D056486:Chemical and Drug Induced Liver Injury; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D006801:Humans; D007527:Isoenzymes / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008107:Liver Diseases / Q000175:diagnosis / Q000503:physiopathology; D008111:Liver Function Tests; D008862:Microsomes, Liver / Q000201:enzymology; D012307:Risk Factors; D015262:Xenobiotics / Q000009:adverse effects* / Q000633:toxicity*
D007527:Isoenzymes; D015262:Xenobiotics; D003577:Cytochrome P-450 Enzyme System