Effect of cadmium on antioxidant status in alloxane-induced diabetic rats.
Fifty-two healthy Swiss Male Albino rats aged two mo were used in this study. They were divided into four groups: control (C), diabetic (D), cadmium (Cd), and diabetic + Cd (D + Cd) groups. Diabetic condition was induced in D and D + Cd groups by administration of alloxane (5 mg/100 g). After this treatment, Cd and D + Cd groups were injected with CdCl2 i.p. (2 mg/kg/wk). At the end of the 2-mo experimental period, thiobarbituric acid reactive substances (TBARS), plasma and erythrocyte selenium (Se), plasma ceruloplasmin (Cp), and vitamin E (vit E) were determined in four groups of rats. The erythrocyte Se was lower in the experimental groups than in the controls. Plasma Se was significantly decreased in the D and D + Cd groups compared with the control group. Plasma Cp was unaltered. Plasma vit E was significantly decreased in Cd group in comparison with the C, D, and D+Cd groups.
Gümüşlü
S
S
Akdeniz University, Faculty of Medicine, Department of Biochemistry, Arapsuyu-Antalya, Turkey.
Yargiçoğlu
P
P
Ağar
A
A
Edremitlioğlu
M
M
Alicigüzel
Y
Y
D000496:Alloxan; D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D002104:Cadmium / Q000494:pharmacology*; D002570:Ceruloplasmin / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000097:blood* / Q000139:chemically induced; D004912:Erythrocytes / Q000378:metabolism; D015227:Lipid Peroxidation; D008297:Male; D051381:Rats; D012643:Selenium / Q000097:blood; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D014810:Vitamin E / Q000097:blood
D000975:Antioxidants; D017392:Thiobarbituric Acid Reactive Substances; D002104:Cadmium; D014810:Vitamin E; D000496:Alloxan; D002570:Ceruloplasmin; D012643:Selenium