Functional promoter polymorphism of the human serotonin transporter: lack of association with panic disorder.
To probe the hypothesis of a role for a functionally relevant 44 bp insertion/deletion of the serotonin transporter promoter in the aetiopathogenesis of panic disorder, we determined the allele frequency of the variant in two samples (combined n = 158) of panic disorder patients (DSMIII-R) and compared it with its allele frequency in two ethnically matched control samples (combined n = 169). The fact that no difference could be observed (x 2 analysis) argues against a major role for this serotonin transporter promoter polymorphism in the aetiopathogenesis of panic disorder.
Deckert
J
J
Department of Psychiatry, Julius-Maximilians-University, Wurzburg, Germany.
Catalano
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Heils
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Di Bella
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Friess
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Politi
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Franke
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Nöthen
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Maier
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Bellodi
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Lesch
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D000483:Alleles; D002352:Carrier Proteins / Q000235:genetics*; D016022:Case-Control Studies; D004198:Disease Susceptibility; D005006:Ethnicity / Q000235:genetics; D005838:Genotype; D005858:Germany / Q000208:ethnology; D006801:Humans; D007558:Italy / Q000208:ethnology; D008562:Membrane Glycoproteins / Q000235:genetics*; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; D016584:Panic Disorder / Q000453:epidemiology / Q000235:genetics*; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic / Q000235:genetics*; D050486:Serotonin Plasma Membrane Transport Proteins
D002352:Carrier Proteins; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins