[Effect of ACTH4-10 on the course of inflammatory and regeneration processes in the rabbit cornea].
The effect of synthetic peptide ACTH4-10 on the course of healing of an experimental wound of the rabbit cornea was studied. Daily subconjunctival injections of the drug in a dose of 10(-8) M for 25 days boosted the migration of leukocytes and macrophages and increased the interstitial and keratocyte proteolysis during the first 10 days of the experiment. Subsequent follow-up showed manifest proliferation of fibroblasts and formation of fibrosis. These data demonstrate expressed effect of synthetic ACTH4-10 on the course of the inflammatory and regeneratory processes in the cornea after partial keratectomy and prove the possibility of short-term local therapy with this peptide as an agent improving corneal wound healing during the initial phases.
Ziangirova
G G
GG
NII of Eye Diseases, RAMN, Moscow.
Bocharov
V E
VE
Malaeva
L V
LV
Olinevich
V B
VB
Sherstnev
V V
VV
D000324:Adrenocorticotropic Hormone / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002634:Chemotaxis, Leukocyte / Q000502:physiology; D003315:Cornea / Q000187:drug effects / Q000503:physiopathology*; D065306:Corneal Injuries; D004195:Disease Models, Animal; D005500:Follow-Up Studies; D007634:Keratitis / Q000188:drug therapy / Q000503:physiopathology*; D008264:Macrophages / Q000502:physiology; D009074:Melanocyte-Stimulating Hormones / Q000494:pharmacology / Q000627:therapeutic use; D018697:Nootropic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D010446:Peptide Fragments / Q000494:pharmacology* / Q000627:therapeutic use; D011817:Rabbits; D014945:Wound Healing / Q000187:drug effects*
D018697:Nootropic Agents; D010446:Peptide Fragments; D000324:Adrenocorticotropic Hormone; D009074:Melanocyte-Stimulating Hormones; C011394:ACTH (4-10)