title: Observer variability in histological malignancy grading of adenoid cystic carcinomas.
abstract: The value of malignancy grading of adenoid cystic carcinomas (ACC) is controversial. Some studies have shown that tumours with a solid growth component have a rapid fatal course, compared to tumours without a solid growth component, in which recurrences develop even many years after initial treatment. Other studies have failed to correlate growth patterns with clinical course. No universally accepted grading system exists and no reproducibility studies of the existing grading systems have been performed. The aim of this study was to examine the reproducibility of grading based on semi-quantitative assessment of the solid growth pattern in ACC. Two different grading systems were assessed by 3 observers on a material of 59 ACC. Interobserver agreement was evaluated using the kappa statistic. The reproducibility of grading was poor, except for the category "solid component constituting 50% or more of the tumour" (kappa = 0.52). It is concluded that quantitative methods are necessary if grading is to be used in prognostic evaluation of ACC. The rarity of the tumours, however, combined with difficulties in diagnosis will impede such investigations unless multicentre studies are undertaken.
authors.affiliation: Department of Pathology, Rigshospitalet, Denmark.
authors.forename: M H
authors.initials: MH
authors.lastname: Therkildsen
authors.forename: J
authors.initials: J
authors.lastname: Reibel
authors.forename: T
authors.initials: T
authors.lastname: Schiødt
mesh_terms: D003528:Carcinoma, Adenoid Cystic / Q000401:mortality / Q000473:pathology*; D006801:Humans; D015588:Observer Variation; D011379:Prognosis; D015203:Reproducibility of Results