Plasma endothelin-1 and tumor necrosis factor-alpha concentrations in pregnant and cyclic rats after low-dose endotoxin infusion.
Plasma endothelin-1 and tumor necrosis factor-alpha were determined in pregnant and cyclic rats after infusion of either endotoxin (1.0 microgram/kg of body weight) or saline solution. After endotoxin, but not after saline solution, administration there was a transient endothelin-1 response in pregnant rats but not cyclic rats. In both reproductive conditions there was an equally high transient tumor necrosis factor-alpha response after endotoxin.
Faas
M M
MM
Department of Obstetrics and Gynecology, University of Groningen, The Netherlands.
Bakker
W W
WW
Valkhof
N
N
Baller
J F
JF
Schuiling
G A
GA
D000818:Animals; D019332:Endothelin-1 / Q000097:blood*; D004731:Endotoxins / Q000008:administration & dosage*; D004971:Estrus / Q000502:physiology*; D005260:Female; D007700:Kinetics; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000097:blood*; D051381:Rats; D017208:Rats, Wistar; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
D019332:Endothelin-1; D004731:Endotoxins; D014409:Tumor Necrosis Factor-alpha