title: Influence of host related factors on the antibody response to trivalent oral polio vaccine in Tunisian infants.
abstract: The low efficiency of trivalent oral polio vaccine (TOPV) in inducing protective antibody titres to polio3 is a problem of great importance in many regions of the world. A prospective study was conducted in 121 Tunisian infants aged 3 months during routine immunization with TOPV under carefully controlled conditions. Seroconversion rates to polio1, polio2 and polio3, one month after the third dose, were 94.7, 100 and 89.5%, respectively. The kinetics of the antibody response showed delayed and more difficult responses to polio3 compared to polio2 and polio1. The following host related factors, previously suggested to interfere with the immune response, were assessed: maternal antibodies; breast-feeding; concurrent enteric infections; and other illnesses. The main factor associated with the lack of seroconversion was concurrent infection with non-polio enteroviruses (NPE) which was found in 50% of non-responders to polio1 and/or to polio3 during the vaccination protocol whereas no NPE was isolated in vaccine responders. The other studied factors seemed not to interfere in the infants according to the locally adopted vaccination schedule and to the specific socio-economic conditions.
authors.affiliation: Institut Pasteur de Tunis, WHO Regional Reference Laboratory on Poliomyelitis, Belvédère, Tunisia.
authors.forename: H
authors.initials: H
authors.lastname: Triki
authors.forename: M V
authors.initials: MV
authors.lastname: Abdallah
authors.forename: R
authors.initials: R
authors.lastname: Ben Aissa
authors.forename: A
authors.initials: A
authors.lastname: Bouratbine
authors.forename: M
authors.initials: M
authors.lastname: Ben Ali Kacem
authors.forename: S
authors.initials: S
authors.lastname: Bouraoui
authors.forename: C
authors.initials: C
authors.lastname: Koubaa
authors.forename: S
authors.initials: S
authors.lastname: Zouari
authors.forename: E
authors.initials: E
authors.lastname: Mohsni
authors.forename: R
authors.initials: R
authors.lastname: Crainic
authors.forename: K
authors.initials: K
authors.lastname: Dellagi
mesh_terms: D000914:Antibodies, Viral / Q000096:biosynthesis* / Q000097:blood; D001942:Breast Feeding; D004751:Enteritis / Q000276:immunology; D005260:Female; D006801:Humans; D007112:Immunity, Maternally-Acquired; D007223:Infant; D007700:Kinetics; D008297:Male; D017955:Poliovirus / Q000276:immunology*; D011055:Poliovirus Vaccine, Oral / Q000276:immunology / Q000494:pharmacology*; D011247:Pregnancy; D011446:Prospective Studies; D014416:Tunisia
chemical_list: D000914:Antibodies, Viral; D011055:Poliovirus Vaccine, Oral