Animal models for intra-abdominal infection.
Animal models are widely used to study intra-abdominal infections. Experimental intra-abdominal infections. Experimental intra-abdominal infection is a bi-phasic process; initially a peritonitis or septic phace caused by E. coli and later a chronic-abscess forming stage, caused by B. fragilis similar to human beings. Various methods have been described. These methods includes challenge of the peritoneum with either endogenous bacteria or inoculation of pure bacteria or fectal material. Non-bacterial models have also been described. Each of these models have their own advantages and disadvantages. The aim and the end points should govern the selection of the right model to be used for experimental purposes. The ideal model should be reliable, standard, reproducible and resembling human disease. A single model with those specifications is yet to be described.
Sayek
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Hacettepe University School of Mecicine, Ankara, Turkey.
D000005:Abdomen / Q000382:microbiology; D018784:Abdominal Abscess / Q000175:diagnosis / Q000382:microbiology* / Q000628:therapy; D000818:Animals; D001442:Bacteroides Infections / Q000209:etiology*; D001441:Bacteroides fragilis; D004195:Disease Models, Animal; D004927:Escherichia coli Infections / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D006801:Humans; D010538:Peritonitis / Q000175:diagnosis / Q000382:microbiology* / Q000628:therapy