title: Effects of MRI abnormalities on WAIS-R performance in solvent abusers.
abstract: OBJECTIVE
  To clarify how chronic solvent abuse affects cognitive function using magnetic resonance imaging as an index of brain damage.
  
  
  METHODS
  A total of 25 chronic solvent abusers underwent magnetic resonance imaging with quantitative neurometry and Wechsler Adult Intelligence Scales revised.
  
  
  RESULTS
  The abusers with white matter change (n=10) showed significantly (P<0.05) lower performance IQ, especially in Digit Symbol subtest (P<0.01). Also, the severity of pontine atrophy was significantly correlated with PIQ (r=0.60, P<0.01).
  
  
  CONCLUSIONS
  These data indicate that solvent abuse causes the decline in the test performance reflecting cognitive and fine motor dysfunction and that white matter changes and pontine atrophy may have some roles in this decline.
authors.affiliation: Department of Neuropsychiatry, School of Medicine, Chiba University, Chuo-ku, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Yamanouchi
authors.forename: S
authors.initials: S
authors.lastname: Okada
authors.forename: K
authors.initials: K
authors.lastname: Kodama
authors.forename: T
authors.initials: T
authors.lastname: Sakamoto
authors.forename: H
authors.initials: H
authors.lastname: Sekine
authors.forename: S
authors.initials: S
authors.lastname: Hirai
authors.forename: A
authors.initials: A
authors.lastname: Murakami
authors.forename: N
authors.initials: N
authors.lastname: Komatsu
authors.forename: T
authors.initials: T
authors.lastname: Sato
mesh_terms: D000328:Adult; D001284:Atrophy; D001927:Brain Diseases / Q000139:chemically induced* / Q000473:pathology / Q000523:psychology*; D005260:Female; D006801:Humans; D007360:Intelligence / Q000187:drug effects; D008279:Magnetic Resonance Imaging; D008297:Male; D011149:Pons / Q000473:pathology; D012997:Solvents / Q000009:adverse effects*; D019966:Substance-Related Disorders; D014888:Wechsler Scales
chemical_list: D012997:Solvents