title: [A case of acute pyrimethamine poisoning].
abstract: Intoxication by pyrimethamine is rare compare to these of patients who ingest a massive dose of amino-4-quinoleine. Clinic manifestations can be delayed and they are specially based on haematologic disorder as shown by literature data. Others organs can be concerned. The authors would like to present the case of a patient with a severe pancytopenia accompanied with: ocular blow like hyperhaemia of conjunctiva then iris siderosis. skin attack as Gũnther's disease. Etiologic treatment by folinic acid is the only deduction. Recovery is complete.
authors.affiliation: SPAR: Service polyvalent d'anesthésie et de réanimation, CNHU 06, République de Bénin.
authors.forename: A R
authors.initials: AR
authors.lastname: Aguemon
authors.forename: D
authors.initials: D
authors.lastname: Atchadé
authors.forename: F
authors.initials: F
authors.lastname: Houngbé
authors.forename: B
authors.initials: B
authors.lastname: Fayomi
mesh_terms: D000208:Acute Disease; D000328:Adult; D000931:Antidotes / Q000627:therapeutic use; D000962:Antimalarials / Q000506:poisoning*; D003229:Conjunctival Diseases / Q000139:chemically induced; D005493:Folic Acid Antagonists / Q000506:poisoning*; D006801:Humans; D006940:Hyperemia / Q000139:chemically induced; D017495:Hyperpigmentation / Q000139:chemically induced; D007499:Iris Diseases / Q000139:chemically induced; D002955:Leucovorin / Q000627:therapeutic use; D008297:Male; D010198:Pancytopenia / Q000139:chemically induced; D017092:Porphyria, Erythropoietic / Q000139:chemically induced; D011739:Pyrimethamine / Q000506:poisoning*; D012806:Siderosis / Q000209:etiology
chemical_list: D000931:Antidotes; D000962:Antimalarials; D005493:Folic Acid Antagonists; D002955:Leucovorin; D011739:Pyrimethamine