title: [Endothelin and nitric oxide].
abstract: Endothelin-1 (ET-1) is an endothelium-derived vasoconstrictor peptide, whereas nitric oxide (NO) is a potent endothelium-derived vasorelaxing factor synthesized from L-arginine by NO synthase (NOS). ET-1 and NO exert many biological actions in a counter-regulatory manner in vascular remodeling and vascular tonus. Furthermore, there exists a close interaction between ET-1 and NO:ET-1 stimulates NO generation, while NO down-regulates the expression of ET-1 gene.
authors.affiliation: Tokyo Medical and Dental University School of Medicine.
authors.forename: M
authors.initials: M
authors.lastname: Iwashina
authors.forename: Y
authors.initials: Y
authors.lastname: Hirata
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D016282:Aspartic Acid Endopeptidases / Q000502:physiology; D019332:Endothelin-1 / Q000737:chemistry / Q000502:physiology*; D000072396:Endothelin-Converting Enzymes; D006801:Humans; D006973:Hypertension / Q000209:etiology*; D008666:Metalloendopeptidases; D008969:Molecular Sequence Data; D009569:Nitric Oxide / Q000502:physiology*; D019001:Nitric Oxide Synthase / Q000502:physiology; D017466:Receptors, Endothelin / Q000502:physiology; D015398:Signal Transduction
chemical_list: D019332:Endothelin-1; D017466:Receptors, Endothelin; D009569:Nitric Oxide; D019001:Nitric Oxide Synthase; D016282:Aspartic Acid Endopeptidases; D008666:Metalloendopeptidases; D000072396:Endothelin-Converting Enzymes