[Local administration of somatostatin in joint diseases in athletes].
Somatostatin is a hormone produced by the hypothalamus, and is widely diffused outside the CNS. It inhibits the secretion of many glands. Recently it has been shown that somatostatin has been proposed in the treatment of phlogistic diseases of the joints by intra-articular administration. The authors show the results of a study conducted in 16 patients (athletes) with arthrosynovitis or tendinitis of the knee or of the ankle, in which somatostatin was administered (250 mg/treatment, 1 treatment/week). Somatostatin significantly reduced pain, improved movement function and decreased the effects of pain on daily activities. The treatment was very well tolerated locally and generally. In conclusion, somatostatin may be considered useful in the treatment of articular and tendineous phlogistic diseases, almost in athletes.
Russo
S
S
Istituto di Farmacologia e Tossicologia, Facoltà di Medicina e Chirurgia, II Università degli Studi, Napoli.
Mangrella
M
M
Vitagliano
S
S
Russo
P
P
Berrino
L
L
D000293:Adolescent; D001168:Arthritis / Q000188:drug therapy*; D006727:Hormone Antagonists / Q000008:administration & dosage*; D006801:Humans; D007270:Injections, Intra-Articular; D008297:Male; D013004:Somatostatin / Q000008:administration & dosage*; D013177:Sports; D013585:Synovitis / Q000188:drug therapy*; D052256:Tendinopathy / Q000188:drug therapy*
D006727:Hormone Antagonists; D013004:Somatostatin