The modulation effect of vitamin E on prostaglandin E2 level and ornithine decarboxylase activity at the promotion phase of lung tumorigenesis in mice.
The present study was undertaken to investigate a mechanism of the inhibitory effect of vitamin E in urethane-induced lung tumorigenesis in mice. We assayed ornithine decarboxylase (ODC) activity and the prostaglandin E2 (PGE2) level in lung at 8 weeks after urethane injection (promotion phase). Excessive vitamin E feeding or indomethacin treatment suppressed the urethane-induced increase in ODC activity, while exogenous PGE2 overcame the effect of vitamin E on ODC activity. Furthermore, the amount of PGE, and the level of ODC activity were well correlated. These results indicate that the vitamin E-induced decrease in PGE2 level probably contributes to the inhibition of ODC induction and the prevention of tumor development in the lung.
Yano
T
T
Division of Applied Food Research, The National Institute of Health and Nutrition, Tokyo, Japan.
Yano
Y
Y
Uchida
M
M
Murakami
A
A
Hagiwara
K
K
Otani
S
S
Ichikawa
T
T
D000818:Animals; D015232:Dinoprostone / Q000096:biosynthesis*; D015536:Down-Regulation; D004790:Enzyme Induction / Q000187:drug effects; D008175:Lung Neoplasms / Q000139:chemically induced / Q000378:metabolism / Q000517:prevention & control*; D008297:Male; D051379:Mice; D009955:Ornithine Decarboxylase / Q000096:biosynthesis*; D011230:Precancerous Conditions / Q000378:metabolism / Q000517:prevention & control*; D014520:Urethane; D014810:Vitamin E / Q000494:pharmacology*
D014810:Vitamin E; D014520:Urethane; D009955:Ornithine Decarboxylase; D015232:Dinoprostone