[Cholestatic hepatitis caused by amoxycillin-clavulanic acid. Report of a new case].
Toxic hepatitis is an infrequent secondary effect of amoxycillin-clavulanic acid with fewer than 30 well documented cases in the literature. Presentation is usually that of acute cholestasis several weeks after the initiation of treatment with this antibiotic. A new case of hepatic toxicity by amoxycillin-clavulanic acid is reported in a 47-years-old male who had taken this drug for a diarrhea syndrome. A brief review of the literature is made with special emphasis on the anatomopathologic aspects.
Bustamante Balén
M
M
Servicio de Medicina Digestiva, Hospital Universitario La Fe, Valencia.
Pérez Aguilar
F
F
Rayón Martín
M
M
García Herola
A
A
Berenguer Lapuerta
J
J
D000658:Amoxicillin / Q000009:adverse effects*; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D019818:Clavulanic Acid; D002969:Clavulanic Acids / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010406:Penicillins / Q000009:adverse effects*
D000900:Anti-Bacterial Agents; D002969:Clavulanic Acids; D010406:Penicillins; D019818:Clavulanic Acid; D000658:Amoxicillin