title: [Alpha-adrenoceptor antagonist (blocker)].
abstract: Alpha adrenergic receptors localized in blood vessels, heart, and kidneys as well as pre- and post-synaptic membrane are significantly important for controlling blood pressure. The treatment of alpha-adrenoceptor blocking drugs induce vasodilatation subsequently lowering blood pressure. Selective alpha-1 adrenoceptor blocking drugs (alpha-1 blockers) are recommended as a first line treatment of hypertension, because of their desirable effect on lipid and glucose metabolism. alpha-1 blockers decrease in total cholesterol and triglycerides, and increase in HDL-cholesterol. It is suggested that alpha-1 blockers improve insulin tolerance, cardiomegaly and atherosclerosis. Although they have many beneficial effect, we should consider adverse effects (orthostatic hypotension, flushing, etc.).
authors.affiliation: Futaba Kosei Hospital, Fukushima Prefectural Welfare Federation of Agricultural Co-operatives.
authors.forename: S
authors.initials: S
authors.lastname: Shigetomi
mesh_terms: D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000209:etiology; D050356:Lipid Metabolism; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects / Q000378:metabolism
chemical_list: D000317:Adrenergic alpha-Antagonists; D011942:Receptors, Adrenergic, alpha