title: Fetal central nervous system anomalies: MR imaging augments sonographic diagnosis.
abstract: OBJECTIVE
  To evaluate fetuses with sonographically suspected central nervous system anomalies to determine the frequency with which obstetric magnetic resonance (MR) imaging adds clinically useful information to that provided by ultrasonography (US).
  
  
  METHODS
  US and MR images and diagnoses in 18 pregnant women were reviewed and compared by two radiologists. Postnatal physical examination and imaging findings and fetal autopsy results were standards. Referring physicians were questioned as to how the additional information provided by MR imaging changed patient counseling.
  
  
  RESULTS
  In 10 (55%) patients, MR imaging demonstrated 11 additional findings. These findings were agenesis of the corpus callosum (n = 4), cerebellar hypoplasia (n = 2), cortical cleft (n = 2), polymicrogyria (n = 1), porencephaly (n = 1), and partial agenesis of the septi pellucidi (n = 1). In seven (39%) patients, additional information provided by MR imaging altered counseling. In one case of suspected agenesis of the corpus callosum, diagnosis at MR imaging was at least partially incorrect.
  
  
  CONCLUSIONS
  US and MR imaging are complementary imaging methods in the evaluation of high-risk pregnancy. When a central nervous system anomaly is suspected at US, MR imaging may demonstrate additional findings that can alter patient counseling.
authors.affiliation: Department of Radiology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
authors.forename: D
authors.initials: D
authors.lastname: Levine
authors.forename: P D
authors.initials: PD
authors.lastname: Barnes
authors.forename: J R
authors.initials: JR
authors.lastname: Madsen
authors.forename: W
authors.initials: W
authors.lastname: Li
authors.forename: R R
authors.initials: RR
authors.lastname: Edelman
mesh_terms: D002490:Central Nervous System / Q000002:abnormalities* / Q000000981:diagnostic imaging; D000013:Congenital Abnormalities / Q000175:diagnosis / Q000000981:diagnostic imaging; D003951:Diagnostic Errors; D005260:Female; D005315:Fetal Diseases / Q000175:diagnosis; D006801:Humans; D008279:Magnetic Resonance Imaging; D011247:Pregnancy; D011296:Prenatal Diagnosis; D016216:Ultrasonography, Prenatal