Effect of supplemental oral L-arginine on exercise capacity in patients with stable angina pectoris.
A randomized, double-blind, placebo-controlled study in patients with clinical symptoms of stable angina pectoris and healed myocardial infarction (n = 22) has shown that oral supplementation with L-arginine (6 g/day for 3 days) increases exercise capacity (tested on a Marquette case 12 treadmill according to the modified Bruce protocol). Results suggest that the inefficient L-arginine/nitric oxide system contributes to limitation of myocardial perfusion and/or peripheral vasodilation during maximum exercise in patients with stable angina pectoris.
Ceremuzyński
L
L
Department of Cardiology, Postgraduate Medical School, and Medical Research Centre, Polish Academy of Sciences, Warsaw.
Chamiec
T
T
Herbaczyńska-Cedro
K
K
D000328:Adult; D000368:Aged; D000787:Angina Pectoris / Q000503:physiopathology*; D001120:Arginine / Q000494:pharmacology*; D004311:Double-Blind Method; D017079:Exercise Tolerance / Q000187:drug effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D014664:Vasodilation / Q000187:drug effects
D001120:Arginine