Intraocular lens implantation in infant monkeys: clinical and histopathological findings.
OBJECTIVE
To determine the long-term effects of intraocular lens (IOL) implantation in infant monkey eyes.


METHODS
Yerkes Regional Primate Research Center, Emory University School of Medicine, Atlanta, Georgia, USA.


METHODS
A 30.00 diopter (D), all-poly(methyl methacrylate) IOL with an overall diameter of 10.0 mm was implanted in the right eye of 11 infant monkeys. Seven monkeys developed postoperative complications and were not followed on a long-term basis. However, 4 monkeys were followed clinically for 4 1/2 years, after which their pseudophakic eyes were examined histopathologically.


RESULTS
The final refractive error in the four pseudophakic eyes with long-term follow-up ranged from -4.75 to +0.75 D. Three of the four eyes had a Soemmering's ring. Only one haptic was in the capsular bag. whereas five had eroded into the iris root/ciliary body. The corneas and posterior segments of the eyes were normal.


CONCLUSIONS
Two-thirds of the eyes having neonatal IOL implantation experienced significant postoperative complications. Haptic location was suboptimal in all four eyes followed for 4 1/2 years. The diameter of the IOLs implanted in these eyes was probably too large. Some of these complications might have been averted by implanting an IOL with a smaller diameter.
Lambert
S R
SR
Emory Eye Center, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322, USA.
Grossniklaus
H E
HE
D000818:Animals; D000831:Animals, Newborn; D002924:Ciliary Body / Q000473:pathology; D005500:Follow-Up Studies; D007498:Iris / Q000473:pathology; D007910:Lenses, Intraocular / Q000009:adverse effects*; D008253:Macaca mulatta; D020366:Methylmethacrylate; D008768:Methylmethacrylates; D011183:Postoperative Complications / Q000209:etiology / Q000473:pathology; D012030:Refractive Errors / Q000175:diagnosis / Q000209:etiology
D008768:Methylmethacrylates; D020366:Methylmethacrylate