title: [Moderately differentiated adenocarcinoma of the rectum: a case report of remarkable response to preoperative administration of FT suppository].
abstract: A 50-year-old man with moderately differentiated adenocarcinoma of the rectum was operated upon following preoperative administration of FT suppository. Digital examination, colonoscopy, and barium enema showed an elevated lesion with central ulcer of the rectum. Microscopically, the biopsy specimen demonstrated moderately differentiated adenocarcinoma. FT suppository (1,500 mg/day for 52 days, total 78 g) was administered on an outpatient basis. Rectal amputation including lymph node dissection was performed. The tumor markedly reduced in size and changed into a small ulcer in the resected specimen. Microscopically, the tumor degenerated and changed into xanthogranulomatous tissue with foamy histiocytes. Only two tubules of degenerated adenocarcinoma remained. FT suppository for rectal cancer is considered to be safe and effective.
authors.affiliation: Dept. of Surgery National Shibukawa Hospital.
authors.forename: M
authors.initials: M
authors.lastname: Izumi
authors.forename: S
authors.initials: S
authors.lastname: Ohwada
authors.forename: S
authors.initials: S
authors.lastname: Kawate
authors.forename: N
authors.initials: N
authors.lastname: Tokizawa
authors.forename: T
authors.initials: T
authors.lastname: Anzai
authors.forename: A
authors.initials: A
authors.lastname: Sasaki
authors.forename: Y
authors.initials: Y
authors.lastname: Morishita
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage*; D003113:Colonoscopy; D003131:Combined Modality Therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D011300:Preoperative Care; D012004:Rectal Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D013488:Suppositories; D005641:Tegafur / Q000008:administration & dosage*
chemical_list: D000964:Antimetabolites, Antineoplastic; D013488:Suppositories; D005641:Tegafur