title: Paraffin tissue block radiography of nonpalpable lesions with calcifications detected at mammography: 5-year consecutive series of surgically excised cases.
abstract: The objective of our study was to evaluate paraffin tissue block radiography following biopsy for breast calcifications at a center for population-based mammography screening. During a 5-year period, we radiographed tissue blocks from 259 breast specimens excised because of nonpalpable calcifications. A total of 124 cases were examined retrospectively and 135 cases were examined prospectively. In 34 of 94 (36 %) retrospectively examined cases with calcifications, the histopathological diagnosis was ductal cancer in situ with or without invasive cancer, compared with 3 of 30 (10 %) cases without calcifications. In 6 cases a primary benign histopathological diagnosis was changed to malignant due to the use of tissue block radiography. Tissue block radiography is a valuable adjunctive method to assure that areas containing calcifications are examined by histopathology.
authors.affiliation: Department of Diagnostic Radiology, University Hospital, S-751 85 Uppsala, Sweden.
authors.forename: E
authors.initials: E
authors.lastname: Thurfjell
authors.forename: A
authors.initials: A
authors.lastname: Lindgren
mesh_terms: D001940:Breast / Q000473:pathology*; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D002114:Calcinosis / Q000175:diagnosis* / Q000000981:diagnostic imaging; D002278:Carcinoma in Situ / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D018270:Carcinoma, Ductal, Breast / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D008327:Mammography; D008852:Microradiography; D010173:Palpation; D016612:Paraffin Embedding; D011446:Prospective Studies; D012189:Retrospective Studies