Low-density lipoprotein ability to generate lipoperoxides in healthy subjects: variations according to age.
Oxidized low-density lipoproteins (LDLs) are recognized to be involved in atherosclerosis development. Since the plasma oxidized LDL assay is inadequate because of the short half-lives of LDLs, measurement of the in vitro ability of LDLs to generate lipoperoxides (LDL-GLs) has been preferred. The present study displays a profile of LDL-GLs in a group of 175 healthy subjects, using a method to measure thiobarbituric acid-reactive substances. We have observed an increased LDL-GL level according to age.
Tronel
H
H
Laboratoire de Biochimie A, CHRU Nancy-Brabois, Vandoeuvre-lès-Nancy, France.
Antebi
H
H
Felden
F
F
Guerci
B
B
Fremont
S
S
Drouin
P
P
Nicolas
J P
JP
Alcindor
L G
LG
D000293:Adolescent; D000328:Adult; D000375:Aging / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D008078:Cholesterol, LDL / Q000097:blood; D005260:Female; D006801:Humans; D008054:Lipid Peroxides / Q000097:blood*; D008055:Lipids / Q000097:blood*; D008077:Lipoproteins, LDL / Q000097:blood*; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D010743:Phospholipids / Q000097:blood; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D014280:Triglycerides / Q000097:blood
D008078:Cholesterol, LDL; D008054:Lipid Peroxides; D008055:Lipids; D008077:Lipoproteins, LDL; D010743:Phospholipids; D017392:Thiobarbituric Acid Reactive Substances; D014280:Triglycerides; D008315:Malondialdehyde