Complex regulation of the BRCA1 gene.
We have analyzed the promoter region of the human BRCA1 gene in detail and demonstrate that the expression of the BRCA1 gene is under complex regulation. First, its transcription is under the control of two promoters generating two distinct transcripts alpha and beta, and second, promoter alpha is shared with the adjacent NBR2 gene and is bi-directional. Both promoter alpha and promoter beta are responsive to estrogen stimulation. We also discerned that there are striking differences in both the genomic organization and immediate cis-control elements of the BRCA1 gene between humans and mice.
Xu
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CF
Division of Medical and Molecular Genetics, UMDS, 8th Floor, Guy's Tower, Guy's Hospital,London SE1 9RT, United Kingdom. xu@icrf.icnet.uk
Chambers
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JA
Solomon
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D000818:Animals; D019313:BRCA1 Protein / Q000235:genetics*; D001483:Base Sequence; D001665:Binding Sites; D001943:Breast Neoplasms / Q000473:pathology; D004958:Estradiol / Q000494:pharmacology; D005786:Gene Expression Regulation; D005796:Genes; D006801:Humans; D051379:Mice; D008969:Molecular Sequence Data; D009363:Neoplasm Proteins; D011401:Promoter Regions, Genetic; D011506:Proteins / Q000235:genetics*; D062085:RNA, Long Noncoding; D017384:Sequence Deletion; D014157:Transcription Factors / Q000378:metabolism; D014158:Transcription, Genetic; D014407:Tumor Cells, Cultured
D019313:BRCA1 Protein; C107422:NBR2 lncRNA, human; D009363:Neoplasm Proteins; D011506:Proteins; D062085:RNA, Long Noncoding; D014157:Transcription Factors; D004958:Estradiol