CD3+ CD8+ CD56- clonal large granular lymphocyte leukaemia and HIV infection.
High-grade malignant lymphomas associated with HIV infection are usually derived from B lymphocytes. Although a broad spectrum of T-cell-derived malignancies has been described, no case of monoclonal T large granular lymphocyte leukaemia has been reported to date. We report a case of clonal T-LGL (CD3+, CD4-, CD8+, CD56-, CD57+) in an HIV-infected. HTLV1/2-negative individual. Large granular lymphocytes are thought to represent activated cytotoxic T lymphocytes. HIV infection, as previously reported for HTLV1/2, may represent a pathway of antigen activation and lead to clonal expansion of T large granular lymphocytes.
Pulik
M
M
Department of Haematology, Argenteuil, France.
Lionnet
F
F
Genet
P
P
Petitdidier
C
C
Jary
L
L
Fourcade
C
C
D000368:Aged; D017252:CD3 Complex / Q000032:analysis*; D015704:CD4 Antigens / Q000032:analysis; D019002:CD56 Antigen / Q000032:analysis*; D018959:CD57 Antigens / Q000032:analysis; D016827:CD8 Antigens / Q000032:analysis*; D002999:Clone Cells; D015658:HIV Infections / Q000150:complications / Q000276:immunology*; D006801:Humans; D016130:Immunophenotyping; D007945:Leukemia, Lymphoid / Q000150:complications / Q000276:immunology*; D008297:Male
D017252:CD3 Complex; D015704:CD4 Antigens; D019002:CD56 Antigen; D018959:CD57 Antigens; D016827:CD8 Antigens