title: Plasma and liver alpha-tocopherol in dairy cows with left abomasal displacement and fatty liver.
abstract: Thirty dairy cows with left abomasal displacement (LAD) and 14 healthy control cows were studied to assess the status of the natural antioxidant vitamin E, lipid peroxidation in the liver (malondialdehyde-formation) and its relationship to hepatic lipidosis. Blood concentrations of alpha-tocopherol, aminotransferase, glutamin dehydrogenase, free fatty acids, beta-hydroxybutyrate and glucose were determined. alpha-tocopherol, tryglyceride, glycogen and malondialdehyde (MDA) in wer liver tissue samples were examined. The dietary alpha-tocopherol intake and its plasma changes in LDA cows were also investigated. Cows were divided into four groups according to their liver triglyceride contents (< 20; 20-80; > 80 mg/g of fresh tissue; and control groups). The lowest plasma vitamin E and the highest liver vitamin E levels were found in cows with highest hepatic triglyceride content. The highest increase in plasma alpha-tocopherol within 5 days was seen in cows with the lowest liver triglyceride (P < 0.01). The liver triglyceride was positively correlated with liver MDA (r = 0.38; P < 0.05) and negatively with plasma alpha-tocopherol (r = -0.41; P < 0.01).
authors.affiliation: Clinic for Diseases of Cattle, School of Veterinary Medicine, Hannover, Germany.
authors.forename: P
authors.initials: P
authors.lastname: Mudron
authors.forename: J
authors.initials: J
authors.lastname: Rehage
authors.forename: H P
authors.initials: HP
authors.lastname: Sallmann
authors.forename: M
authors.initials: M
authors.lastname: Mertens
authors.forename: H
authors.initials: H
authors.lastname: Scholz
authors.forename: G
authors.initials: G
authors.lastname: Kovac
mesh_terms: D020155:3-Hydroxybutyric Acid; D000018:Abomasum / Q000002:abnormalities*; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D002417:Cattle; D002418:Cattle Diseases / Q000097:blood / Q000378:metabolism*; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005234:Fatty Liver / Q000097:blood / Q000378:metabolism / Q000662:veterinary*; D005260:Female; D005969:Glutamate Dehydrogenase / Q000097:blood; D006003:Glycogen / Q000032:analysis / Q000097:blood; D006885:Hydroxybutyrates / Q000097:blood; D050356:Lipid Metabolism; D015227:Lipid Peroxidation / Q000502:physiology; D008099:Liver / Q000737:chemistry* / Q000378:metabolism; D008315:Malondialdehyde / Q000032:analysis / Q000378:metabolism; D000637:Transaminases / Q000097:blood; D014280:Triglycerides / Q000032:analysis / Q000097:blood; D014810:Vitamin E / Q000032:analysis* / Q000097:blood* / Q000378:metabolism
chemical_list: D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D006885:Hydroxybutyrates; D014280:Triglycerides; D014810:Vitamin E; D008315:Malondialdehyde; D006003:Glycogen; D005969:Glutamate Dehydrogenase; D000637:Transaminases; D020155:3-Hydroxybutyric Acid