title: Septic complications after biliary tract stone surgery: a review and report of the European prospective study.
abstract: We report a prospective, controlled study of the incidence of septic complications following biliary tract stone surgery. This study included a total of 280 patients operated on in eight hospitals in various European countries. In this study the computer program "Surgery" was used. Of 280 patients, 77 (27.5%) were male and 203 (72.5%) were female. The age ranged from 20 to 92 years (mean 54.8 years); 78.9% of the cases corresponded to clean-contaminated surgery; 85% of the patients received antibiotic prophylaxis with cefazolin. Twenty-one patients developed postoperative septic complications (7.5%) of which 12 (4.3%) were wound infections; five patients (1.8%) had intra-abdominal infections. The wound infection rate was 3.2% in clean-contaminated surgery, 7.7% in contaminated and 20% in dirty (p < 0.02). In laparoscopic cholecystectomy the global rate of septic complications was 3.6% vs. 12.6% in open cholecystectomy (p < 0.01); 2.4% and 6.3% wound infection respectively. The mean age of patients who developed postoperative septic complications was 61.5 years and 54.2 years old who did not develop any complications (p < 0.03). The duration of the postoperative period was 5 days in patients without infection and 13 days in patients with infection (p < 0.0001). Two patients died, one of them (0.4%) caused by sepsis. In addition to the European prospective study, a review of the problems of sepsis in biliary surgery was carried out.
authors.affiliation: Department of Surgery, University of Santiago de Compostela, Hospital General de Galicia, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Cainzos
authors.forename: I
authors.initials: I
authors.lastname: Sayek
authors.forename: H
authors.initials: H
authors.lastname: Wacha
authors.forename: I
authors.initials: I
authors.lastname: Pulay
authors.forename: L
authors.initials: L
authors.lastname: Dominion
authors.forename: P F
authors.initials: PF
authors.lastname: Aeberhard
authors.forename: T
authors.initials: T
authors.lastname: Hau
authors.forename: A O
authors.initials: AO
authors.lastname: Aasen
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D019072:Antibiotic Prophylaxis / Q000379:methods; D001419:Bacteria / Q000302:isolation & purification; D001659:Biliary Tract / Q000382:microbiology; D001662:Biliary Tract Surgical Procedures / Q000009:adverse effects*; D002769:Cholelithiasis / Q000601:surgery*; D005060:Europe; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000453:epidemiology* / Q000209:etiology / Q000517:prevention & control; D011446:Prospective Studies; D018805:Sepsis / Q000453:epidemiology* / Q000209:etiology / Q000517:prevention & control
chemical_list: D000900:Anti-Bacterial Agents