title: Endometrial hyperplasia and the risk of endometrial carcinoma.
abstract: OBJECTIVE
  To determine the incidence of endometrial carcinoma in endometrial hyperplasia and try to identify those patients at greatest risk.
  
  
  METHODS
  We conducted a retrospective study of 116 patients who had simple, complex or mixed (simple with focal complex) endometrial hyperplasia with or without atypia, from January 1991 to December 1994.
  
  
  RESULTS
  Twenty-nine patients had endometrial hyperplasia with atypia and 87 without atypia. Incidence of endometrial carcinoma was 27.6% in those with atypia; and 3.4% in those without atypia. All were stage I (A or B) adenocarcinomas. Polycystic Ovary Disease and subfertility were found significantly in the cases with cytological atypia; however, they were not significant in the cases with carcinoma. No significant historical differences that could predict carcinoma were found.
authors.affiliation: Department of Gynaecologic Oncology & Urogynaecology, Kandang Kerbau Hospital, Singapore.
authors.forename: S P
authors.initials: SP
authors.lastname: Ho
authors.forename: K T
authors.initials: KT
authors.lastname: Tan
authors.forename: M W
authors.initials: MW
authors.lastname: Pang
authors.forename: T H
authors.initials: TH
authors.lastname: Ho
mesh_terms: D000230:Adenocarcinoma / Q000150:complications*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004714:Endometrial Hyperplasia / Q000150:complications*; D016889:Endometrial Neoplasms / Q000150:complications*; D005260:Female; D006801:Humans; D015994:Incidence; D008875:Middle Aged; D011085:Polycystic Ovary Syndrome / Q000473:pathology; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors