[Hypertension and steroid hormones].
Mineralocorticoid excess causes hypertension by facilitating the sodium retension at renal tubules. Such mechanism operates in hypertension such as primary hyperaldosteronism and some forms of congenital adrenal hyperplasia. Recently, deficient cortisol metabolism in the aldosterone target organ has been recognized as a novel form of hypertension known as apparent mineralocorticoid excess. In this review hypertensive disorders caused by adrenal cortical hormones is briefly stated.
Miyamori
I
I
Third Department of Internal Medicine, Fukui Medical School.
D042842:11-beta-Hydroxysteroid Dehydrogenases; D000305:Adrenal Cortex Hormones / Q000502:physiology*; D000312:Adrenal Hyperplasia, Congenital; D006801:Humans; D006854:Hydrocortisone / Q000502:physiology; D006913:Hydroxysteroid Dehydrogenases / Q000172:deficiency / Q000235:genetics; D006929:Hyperaldosteronism / Q000150:complications; D006973:Hypertension / Q000209:etiology*; D007684:Kidney Tubules / Q000378:metabolism; D008901:Mineralocorticoids / Q000502:physiology; D012964:Sodium / Q000378:metabolism; D013252:Steroid 11-beta-Hydroxylase / Q000235:genetics; D013254:Steroid 17-alpha-Hydroxylase / Q000235:genetics
D000305:Adrenal Cortex Hormones; D008901:Mineralocorticoids; D012964:Sodium; D006913:Hydroxysteroid Dehydrogenases; D042842:11-beta-Hydroxysteroid Dehydrogenases; D013254:Steroid 17-alpha-Hydroxylase; D013252:Steroid 11-beta-Hydroxylase; D006854:Hydrocortisone