title: Influence of intraperitoneal vancomycin on peritoneal dialysis efficiency. A clinical study.
abstract: Peritonitis is a major complication of intermittent peritoneal dialysis (IPD); over 70% of the infections are caused by Gram-positive bacteria. Vancomycin (V) is the antibiotic of choice in the treatment of peritonitis caused by G(+). The influence of vancomycin on peritoneal transport in IPD patients has not been described before. We have investigated the effect of intraperitoneal vancomycin on dialysis efficiency in 8 IPD patients using dialysis solutions containing either lactate or acetate. The following parameters were measured: net ultrafiltration (UF), concentration ratios (D/P) of urea, creatinine, potassium, peritoneal clearances (ml/min) of urea, creatinine, potassium, mass transfer of sodium (MTNa), sodium sieving index (SCNa). It has been found that vancomycin significantly decreases D/P urea (p < 0.05) and creatinine (p < 0.05). We found also a significant decrease of mean clearance of urea (p < 0.05) and creatinine (p < 0.05). The mean clearance of potassium did not change significantly. There was no significant change in UF, MTNa, and SCNa. Our preliminary data suggest that vancomycin decreases the permeability of peritoneum for certain low molecules in IPD patients which may have a negative impact on dialysis efficiency.
authors.affiliation: Department of Nephrology, Surgery, Medical Academy, Lublin, Poland.
authors.forename: L
authors.initials: L
authors.lastname: Janicka
authors.forename: A
authors.initials: A
authors.lastname: Ksiazek
authors.forename: J
authors.initials: J
authors.lastname: Solski
authors.forename: K
authors.initials: K
authors.lastname: Janicki
mesh_terms: D000328:Adult; D000368:Aged; D002463:Cell Membrane Permeability / Q000187:drug effects*; D003404:Creatinine / Q000378:metabolism; D005260:Female; D006801:Humans; D007674:Kidney Diseases / Q000628:therapy*; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D010530:Peritoneal Dialysis; D010537:Peritoneum / Q000378:metabolism*; D011188:Potassium / Q000378:metabolism; D011446:Prospective Studies; D014462:Ultrafiltration; D014508:Urea / Q000378:metabolism; D014640:Vancomycin / Q000494:pharmacology*
chemical_list: D014640:Vancomycin; D014508:Urea; D003404:Creatinine; D011188:Potassium