[A study of HIA-DR antigen expression in nasopharyngeal carcinoma and its relation with clinical pathology and prognosis].
In order to clarify the relationship between HLA-DR antigen expression of nasopharyngeal carcinoma (NPC) and the clinicopathology and prognosis of NPC, immunohistochemical studies on HLA-DR antigen expression in 77 NPC cases were performed. The results showed that the positive rate of HLA-DR was 44.2% in this series. Non-neoplastic epithelium did not express this antigen. A close association was found between expression of HLA-DR antigen and the clinical staging of NPC. The positive rate of HLA-DR gradually decreased with tumor progression, showing a remarkable difference among tumors in different clinical stages (P < 0.05). Analysis of patient survival demonstrated that the prognosis of NPC patients with HLA-DR expression was significantly better than those without (P < 0.01). The above results give support to the possibility of immunomodulation of tumors.
Liu
B
B
Hunan Tumor Hospital, Changsha.
Su
Z
Z
Chen
S
S
D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000276:immunology* / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D006684:HLA-DR Antigens / Q000032:analysis*; D006801:Humans; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000276:immunology* / Q000473:pathology; D009367:Neoplasm Staging; D011379:Prognosis
D006684:HLA-DR Antigens