[New possibilities in prevention and correction of postoperative suppurative-septic complications and multiple organ failure in oncological surgery].
The functional status of the oxidative-antioxidative system was studied in 72 patients after vast cancer operations. Traditional surgical treatment and its combination with intraoperative irradiation were shown to lead to tense antioxidative defense and to suppressed T-cell immunity and to call for antioxidative and immunomodulating therapy. High intraoperative blood loss complicated by hemorrhagic shock injured the oxidative-antioxidative system greatly. The magnitude of this damage correlated with the rate of prehypoxia. Addition of the potent antioxidant Ceruloplasmin to the drug regimen normalized a recovery period, helped to correct posthypoxic multiorgan insufficiency, to recover oxidative-antioxidative balance, and to decrease the incidence of pyoinflammatory complications. Patients with endogenous intoxication showed activated lipid peroxidation, decreased functional activity of antioxidative defense components and of T-cell immunity in homeostasis. The use of Ceruloplasmin and Laprot had pronounced antiinflammatory and detoxifying effects on the patient's body and activated its antioxidative defense.
Edeleva
N V
NV
Osipova
M A
MA
Nemtsova
E R
ER
Sergeeva
T V
TV
Oganezov
V K
VK
Iakubovskaia
R I
RI
Vetsheva
M S
MS
Beresnev
V A
VA
D000276:Adjuvants, Immunologic / Q000627:therapeutic use; D000328:Adult; D000368:Aged; D000975:Antioxidants; D002570:Ceruloplasmin / Q000627:therapeutic use*; D006801:Humans; D007781:Lactoferrin / Q000627:therapeutic use*; D015227:Lipid Peroxidation; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000276:immunology / Q000517:prevention & control* / Q000628:therapy; D011183:Postoperative Complications / Q000276:immunology / Q000517:prevention & control* / Q000628:therapy; D018805:Sepsis / Q000276:immunology / Q000517:prevention & control* / Q000628:therapy; D013492:Suppuration; D013601:T-Lymphocytes / Q000276:immunology
D000276:Adjuvants, Immunologic; D000975:Antioxidants; D002570:Ceruloplasmin; D007781:Lactoferrin