Parathyroid hormone-related peptide and the parathyroid hormone/parathyroid hormone-related peptide receptor in skeletal development.
Parathyroid hormone-related peptide has recently been shown to have important functions in the control of cellular growth and differentiation. Studies using knockout and transgenic technology have played a key part in the development of our understanding of its physiological role in endochondral bone development and adult skeletal homeostasis. Acting, at least partly, through the parathyroid hormone/parathyroid hormone-related peptide receptor, parathyroid hormone-related peptide profoundly influences chondrocytic and osteogenic cell biology. Further understanding of these functions may have important implications in the pathophysiology and treatment of human skeletal disorders, including osteoporosis.
Karaplis
A C
AC
Department of Medicine, McGill University, Montreal, Canada.
Vautour
L
L
D000328:Adult; D000818:Animals; D017209:Apoptosis; D001846:Bone Development / Q000502:physiology*; D001851:Bone Diseases, Metabolic / Q000209:etiology / Q000378:metabolism; D016723:Bone Remodeling / Q000502:physiology; D002356:Cartilage / Q000166:cytology / Q000378:metabolism; D002454:Cell Differentiation; D053823:Hedgehog Proteins; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D010006:Osteoblasts / Q000378:metabolism; D010024:Osteoporosis / Q000188:drug therapy; D044162:Parathyroid Hormone-Related Protein; D011506:Proteins / Q000235:genetics / Q000378:metabolism* / Q000627:therapeutic use; D044168:Receptor, Parathyroid Hormone, Type 1; D018016:Receptors, Parathyroid Hormone / Q000378:metabolism*; D015534:Trans-Activators
D053823:Hedgehog Proteins; C470121:PTHLH protein, human; D044162:Parathyroid Hormone-Related Protein; D011506:Proteins; D044168:Receptor, Parathyroid Hormone, Type 1; D018016:Receptors, Parathyroid Hormone; D015534:Trans-Activators