title: [Interaction of a substance based on phytoecdysteroids (BTK-8L) with components of fractionated chromatin from intact rat liver].
abstract: Results of the study of interaction of the phytoecdysteroid preparation (BTK-8L) with fractionated rat liver nuclear chromatin were described. It was shown that the interaction resulted in the "loosening" of the histone proteins structure both in active and repressed chromatin. At the same time the reparative DNA synthesis in the repressed fraction was stimulated. The Change revealed might be the basis of protective properties of BTK-8L as to chromatin at chloro and organophosphorus intoxications.
authors.forename: R G
authors.initials: RG
authors.lastname: Primak
authors.forename: E L
authors.initials: EL
authors.lastname: Levitskiĭ
authors.forename: Iu I
authors.initials: IuI
authors.lastname: Gubskiĭ
authors.forename: A G
authors.initials: AG
authors.lastname: Goriushko
authors.forename: Iu D
authors.initials: IuD
authors.lastname: Kholodova
authors.forename: I E
authors.initials: IE
authors.lastname: Vistunova
mesh_terms: D000818:Animals; D002843:Chromatin / Q000378:metabolism*; D004247:DNA / Q000187:drug effects; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D009690:Nucleic Acid Conformation; D011487:Protein Conformation; D051381:Rats; D017208:Rats, Wistar; D013256:Steroids / Q000494:pharmacology*
chemical_list: C088577:BTK 8L preparation; D002843:Chromatin; D013256:Steroids; D004247:DNA