[A comparative morphometric and histologic study of five bone substitute materials].
OBJECTIVE
To investigate and compare the osteogenesis of bone substitute materials.


METHODS
52 Chbb: ch rabbits were divided into 5 groups. Five different porous biomaterials, including natural bovine hydroxyapatite (Bio-OSS, BK V/1), semi-synthetic coral hydroxyapatite interpore 500, synthetic tricalcium phosphate CEROS 82 and glass POROLITH, were implanted together with free periosteum into the muscle of rabbits for up to 3 and 6 weeks. Undecalcified sections were prepared for microradiography, light and UV microscopy, and morphometry.


RESULTS
Bone ingrowth was present in all such implantats. Bone formation was limited to the periphery of the Ceros blocks, that are lack of pore interconnection, while the other 4 materials with an interconnected porous system were infiltrated by bone into the centrum. Planimetric analyses showed that the specimens were composed of 6.5%-19.0% new bone at the 3rd week and 14.2%-25% at the 6th week respectively. The difference of bone ingrowth was only significant between Bio-OSS and BK V/1 at the 3rd week. No statistically significant difference of bone volume was found within the 6 week groups. There was a positive correlation between the new bone volume and the porosity of the materials.


CONCLUSIONS
For the bone ingrowth, the structure of the materials, specifically the pore and pore interconnections, is more impatant than the chemical composition.
Chen
L
L
Department of Surgery, Second Affiliated Hospital, Zhejiang Medical University, Hangzhou.
Klaes
W
W
Assenmacher
S
S
D000818:Animals; D001672:Biocompatible Materials; D018786:Bone Substitutes; D017886:Durapatite; D006882:Hydroxyapatites; D016348:Osseointegration; D010521:Periosteum / Q000637:transplantation; D019736:Prostheses and Implants; D011817:Rabbits
D001672:Biocompatible Materials; D018786:Bone Substitutes; D006882:Hydroxyapatites; D017886:Durapatite