Detection of 14-3-3 protein in the CSF of genetic Creutzfeldt-Jakob disease.
The 14-3-3 protein, a protein involved in signal transduction, is present in the CSF of patients with Creutzfeldt-Jakob disease (CJD) and not in patients with other dementing diseases. We show here that this is also true for patients with E200K CJD, but not for healthy carriers of the mutation.
Rosenmann
H
H
Department of Neurolog, Hadassah University Hospital, Jerusalem, Israel.
Meiner
Z
Z
Kahana
E
E
Halimi
M
M
Lenetsky
E
E
Abramsky
O
O
Gabizon
R
R
D048948:14-3-3 Proteins; D002353:Carrier State / Q000134:cerebrospinal fluid; D007562:Creutzfeldt-Jakob Syndrome / Q000134:cerebrospinal fluid* / Q000235:genetics; D006801:Humans; D007118:Immunoassay; D009154:Mutation; D009422:Nervous System Diseases / Q000134:cerebrospinal fluid / Q000235:genetics; D011506:Proteins / Q000032:analysis*; D014446:Tyrosine 3-Monooxygenase
D048948:14-3-3 Proteins; D011506:Proteins; D014446:Tyrosine 3-Monooxygenase