title: Copper-binding motifs in catalysis, transport, detoxification and signaling.
abstract: Copper is required for many biological processes but is toxic at high cellular concentrations, so levels in the cell must be strictly controlled. Copper-binding motifs have been identified and characterized in many proteins. The way in which copper is coordinated by these motifs is important for the transport and distribution of intracellular copper and for the effective functioning of copper-dependent enzymes.
authors.affiliation: Department of Biological Chemistry, The University of Michigan Medical School, Ann Arbor, Michigan 48109-0606, USA.
authors.forename: K A
authors.initials: KA
authors.lastname: Koch
authors.forename: M M
authors.initials: MM
authors.lastname: Peña
authors.forename: D J
authors.initials: DJ
authors.lastname: Thiele
mesh_terms: D000818:Animals; D001483:Base Sequence; D001665:Binding Sites; D001693:Biological Transport, Active; D002352:Carrier Proteins / Q000378:metabolism; D002384:Catalysis; D002570:Ceruloplasmin / Q000737:chemistry / Q000378:metabolism; D003300:Copper / Q000378:metabolism* / Q000633:toxicity; D004247:DNA / Q000235:genetics / Q000378:metabolism; D006527:Hepatolenticular Degeneration / Q000378:metabolism; D006801:Humans; D008658:Inactivation, Metabolic; D007706:Menkes Kinky Hair Syndrome / Q000378:metabolism; D008667:Metalloproteins / Q000737:chemistry / Q000378:metabolism; D008958:Models, Molecular; D011487:Protein Conformation; D015398:Signal Transduction; D014018:Tissue Distribution
chemical_list: D002352:Carrier Proteins; D008667:Metalloproteins; D003300:Copper; D004247:DNA; D002570:Ceruloplasmin