title: Measurement of the ferric diffusion coefficient in agarose and gelatine gels by utilization of the evolution of a radiation induced edge as reflected in relaxation rate images.
abstract: A method has been developed to determine the diffusion coefficients of ferric ions in ferrous sulphate doped gels. A radiation induced edge was created in the gel, and two spin-echo sequences were used to acquire a pair of images of the gel at different points of time. For each of these image pairs, a longitudinal relaxation rate image was derived. From profiles through these images, the standard deviations of the Gaussian functions that characterize diffusion were determined. These data provided the basis for the determination of the ferric diffusion coefficients by two different methods. Simulations indicate that the use of single spin-echo images in this procedure may in some cases lead to a significant underestimation of the diffusion coefficient. The technique was applied to different agarose and gelatine gels that were prepared, irradiated and imaged simultaneously. The results indicate that the diffusion coefficient is lower in a gelatine gel than in an agarose gel. Addition of xylenol orange to a gelatine gel lowers the diffusion coefficient from 1.45 to 0.81 mm2 h-1, at the cost of significantly lower Rl sensitivity. The addition of benzoic acid to the latter gel did not increase the Rl sensitivity.
authors.affiliation: Department of Medical Physics and Technology, Norwegian Radium Hospital, Montebella, Oslo, Norway.
authors.forename: T V
authors.initials: TV
authors.lastname: Pedersen
authors.forename: D R
authors.initials: DR
authors.lastname: Olsen
authors.forename: A
authors.initials: A
authors.lastname: Skretting
mesh_terms: D001565:Benzoates; D019817:Benzoic Acid; D004058:Diffusion; D005780:Gelatin; D005782:Gels; D007501:Iron; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D008962:Models, Theoretical; D016011:Normal Distribution; D019047:Phantoms, Imaging; D011829:Radiation Dosage; D012044:Regression Analysis; D012680:Sensitivity and Specificity; D012685:Sepharose
chemical_list: D001565:Benzoates; D005782:Gels; D019817:Benzoic Acid; D005780:Gelatin; D012685:Sepharose; D007501:Iron