[Involvement of monoamine oxidases in formation of 4-hydroxyphenylethanol, major component of tribulin A].
Pathways of 4-hydroxyphenylethanol formation were studied in the bovine brain. Incubation of brain homogenates with tyramine or tyrosine increased 4-hydroxyphenylethanol content only in the presence of NADH. Tyramine produced more pronounced augmentation of 4-hydroxyphenylethanol content than tyrosine. Tyrosine preparations were not contamined with tyramine. This suggests that 4-hydroxyphenylethanol may be formed from tyramine and tyrosine in NADH-dependent process. Preincubation of homogenates with 0.1 mM pargyline completely inhibited monoamine oxidases A and B and prevented NADH-dependent formation of 4-hydroxyphenylethanol from tyramine. The latter suggests that MAO is involved in formation of 4-hydroxyphenylethanol.
Panova
N G
NG
NII of Biomedical Chemistry RAMN, Moscow.
Veselovskaia
N V
NV
Medvedev
A E
AE
D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D002417:Cattle; D008401:Gas Chromatography-Mass Spectrometry; D007510:Isatin; D008297:Male; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology*; D009243:NAD / Q000494:pharmacology; D010626:Phenylethyl Alcohol / Q000031:analogs & derivatives* / Q000378:metabolism; D010675:Pheromones / Q000096:biosynthesis*; D014439:Tyramine / Q000494:pharmacology; D014443:Tyrosine / Q000494:pharmacology
D000317:Adrenergic alpha-Antagonists; D008996:Monoamine Oxidase Inhibitors; D010675:Pheromones; D009243:NAD; C011867:4-hydroxyphenylethanol; D014443:Tyrosine; D007510:Isatin; C039776:tribulin; D010626:Phenylethyl Alcohol; D014439:Tyramine