Prospective population based survey of outcome of pregnancy in diabetic women: results of the Northern Diabetic Pregnancy Audit, 1994.
OBJECTIVE
To determine whether the St Vincent declaration (1989) target of diabetic pregnancy outcome approximating non-diabetic pregnancy outcome in near to being achieved.


METHODS
Prospective collection of population based information on pregnancies in women with diabetes from all participating hospitals.


METHODS
District general and teaching hospitals of the former Northern region.


METHODS
111 diabetic women booking with pregnancy during 1 January to 31 December 1994.


METHODS
Diabetic control, perinatal mortality rate, fetal abnormality rate.


RESULTS
The perinatal mortality rate was 48/1000 for diabetic pregnancies compared with 8.9/1000 for the background population (odds ratio 5.38; 95% confidence interval 2.27 to 12.70) and the neonatal mortality rate was 59/1000 compared with 3.9/1000 (15.0; 6.77 to 33.10). Two late neonatal deaths were due to congenital heart defects. Six per cent of all fetal losses (6/109 cases) were due to major malformations. The congenital malformation rate was 83/1000 compared with 21.3/1000 (3.76; 2.00 to 7.06) in the background population.


CONCLUSIONS
Diabetic pregnancy remains a high risk state with perinatal mortality and fetal malformation rates much higher than in the background population.
Hawthorne
G
G
Robson
S
S
Ryall
E A
EA
Sen
D
D
Roberts
S H
SH
Ward Platt
M P
MP
D000013:Congenital Abnormalities / Q000453:epidemiology; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000453:epidemiology; D004739:England / Q000453:epidemiology; D005260:Female; D005313:Fetal Death / Q000453:epidemiology; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D007226:Infant Mortality; D007231:Infant, Newborn; D007752:Obstetric Labor, Premature / Q000453:epidemiology; D011247:Pregnancy; D011256:Pregnancy Outcome; D011254:Pregnancy in Diabetics / Q000097:blood / Q000453:epidemiology; D011446:Prospective Studies
D006442:Glycated Hemoglobin