title: Lupus profundus/panniculitis.
abstract: A 25-year-old Caucasian woman developed two areas of tender panniculitis on her left thigh. While one lesion ulcerated, the other showed no overlying cutaneous changes. Histological examination showed lymphocytic perivascular and periappendageal infiltrates, and direct immunofluorescence revealed granular immunoglobulin deposits at the dermal-epidermal junction in the skin overlying the lesions. Laboratory tests revealed lymphopenia, anemia and an increased blood sedimentation rate. The serology for syphilis was false positive. For several months the patient had also been suffering from arthralgia with palpable synovitis of the wrist and several interphalangeal joints. Overall, these clinical findings are consistent with the diagnosis of lupus profundus/panniculitis associated with mild systemic LE.
authors.affiliation: Department of Dermatology, University Hospital of Zürich, Switzerland.
authors.forename: T M
authors.initials: TM
authors.lastname: Kündig
authors.forename: R M
authors.initials: RM
authors.lastname: Trüeb
authors.forename: M
authors.initials: M
authors.lastname: Krasovec
mesh_terms: D000328:Adult; D000740:Anemia / Q000473:pathology; D018771:Arthralgia / Q000473:pathology; D001799:Blood Sedimentation; D001808:Blood Vessels / Q000473:pathology; D003176:Complement C3 / Q000032:analysis; D003937:Diagnosis, Differential; D005260:Female; D019085:Fluorescent Antibody Technique, Direct; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007871:Leg Ulcer / Q000473:pathology; D008180:Lupus Erythematosus, Systemic / Q000473:pathology; D008214:Lymphocytes / Q000473:pathology; D008231:Lymphopenia / Q000473:pathology; D015435:Panniculitis, Lupus Erythematosus / Q000473:pathology*; D012867:Skin / Q000098:blood supply / Q000473:pathology; D013585:Synovitis / Q000473:pathology; D013588:Syphilis Serodiagnosis; D013848:Thigh / Q000473:pathology
chemical_list: D003176:Complement C3; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M