title: Developmental outcomes in children receiving resection surgery for medically intractable infantile spasms.
abstract: Two-year postsurgical developmental outcomes were assessed in 24 children with infantile spasms who underwent resective surgery. The mean age of onset of infantile spasms was 12.0 weeks and the mean age at surgery was 20.8 months. Developmental outcomes were assessed using the Vineland Adaptive Behavior Scales (VABS). There was a significant increase in developmental level at 2 years postsurgery compared with presurgical levels. At 2 years postsurgery only one of the children in this series was severely retarded. The developmental outcomes of patients in the series were better than those in prior studies of symptomatic patients receiving medical treatment for infantile spasms. It is surprising that the children in the UCLA series frequently had developmental outcomes equal to and sometimes superior to other groups of children with infantile spasms, since all the UCLA patients were symptomatic, had neurologic deficits and had failed to respond to adrenocorticotrophic hormone (ACTH) and antiepileptic drugs. The 2-year postsurgery developmental outcomes were best for the children who received surgery when they were relatively young and who had the highest level of developmental attainments presurgically.
authors.affiliation: Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, 90024-1759, USA.
authors.forename: R F
authors.initials: RF
authors.lastname: Asarnow
authors.forename: C
authors.initials: C
authors.lastname: LoPresti
authors.forename: D
authors.initials: D
authors.lastname: Guthrie
authors.forename: T
authors.initials: T
authors.lastname: Elliott
authors.forename: V
authors.initials: V
authors.lastname: Cynn
authors.forename: W D
authors.initials: WD
authors.lastname: Shields
authors.forename: D A
authors.initials: DA
authors.lastname: Shewmon
authors.forename: R
authors.initials: R
authors.lastname: Sankar
authors.forename: W J
authors.initials: WJ
authors.lastname: Peacock
mesh_terms: D000203:Activities of Daily Living; D000324:Adrenocorticotropic Hormone / Q000627:therapeutic use; D000367:Age Factors; D001927:Brain Diseases / Q000150:complications / Q000175:diagnosis / Q000601:surgery; D002540:Cerebral Cortex / Q000601:surgery*; D002657:Child Development; D005260:Female; D006801:Humans; D007223:Infant; D007361:Intelligence Tests; D008297:Male; D011184:Postoperative Period; D012044:Regression Analysis; D012640:Seizures / Q000209:etiology / Q000517:prevention & control; D013036:Spasms, Infantile / Q000188:drug therapy / Q000209:etiology / Q000517:prevention & control*; D016896:Treatment Outcome
chemical_list: D000324:Adrenocorticotropic Hormone