title: Effect of age on P300 wave.
abstract: 30 healthy elderly males (mean age 77.4 +/- 4.3 yrs) were subjects in this study. Equal number of young males (mean age 22 +/- 3.5 years) and middle aged subjects (mean age 46 +/- 3.2 years) served as control. P300 wave was estimated using a Neuropack 4 model of Nihon Kohden EMG machine. We observed a significantly increased latency, poorly defined and non reproducible P300 wave in 90% old subjects while in young the latency was in normal limits and the wave was well defined and reproducible. We presume P300 could serve as a future potential marker of the neurophysiological basis of aging.
authors.affiliation: Department of Neurology, King George's College, Lucknow.
authors.forename: S
authors.initials: S
authors.lastname: Jha
authors.forename: R
authors.initials: R
authors.lastname: Shukla
authors.forename: D
authors.initials: D
authors.lastname: Nag
authors.forename: A M
authors.initials: AM
authors.lastname: Kar
authors.forename: A
authors.initials: A
authors.lastname: Agarwal
mesh_terms: D000161:Acoustic Stimulation; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D004576:Electromyography / Q000295:instrumentation; D018913:Event-Related Potentials, P300 / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009482:Neurophysiology; D011930:Reaction Time / Q000502:physiology; D015203:Reproducibility of Results; D012815:Signal Processing, Computer-Assisted