Annexin V-coated intraocular lenses.
OBJECTIVE
To assess whether annexin V-coated poly(methyl methacrylate) (PMMA) intraocular lenses (IOLs) prevent postoperative inflammation in rabbit eyes.


METHODS
Department of Ophthalmology, Hôpital Purpan, Toulouse, France.


METHODS
Thirteen IOLs coated with annexin V were implanted in 13 rabbit eyes; the contralateral eyes received uncoated IOLs. Postoperative fibrin was quantitated by daily slitlamp examination until the anterior chamber was completely clear. Results were analyzed using a Wilcoxon test. Ocular toxicity was evaluated by light and electron microscopy.


RESULTS
Eyes with the annexin V-coated IOLs had less severe inflammation on the first postoperative day, and the inflammation resolved more quickly than in eyes with uncoated IOLs (P < .05). No annexin V was released postoperatively, nor were there signs of ocular toxicity.


CONCLUSIONS
Annexin V-coated lenses effectively reduced postoperative inflammation in rabbit eyes.
Chollet
P
P
Department of Ophthalmology, Purpan Hospital, Toulouse, France.
Malecaze
F
F
Le Toan
P
P
Lamche
H
H
Arné
J L
JL
D000818:Animals; D017304:Annexin A5 / Q000032:analysis / Q000378:metabolism*; D002387:Cataract Extraction / Q000009:adverse effects; D009877:Endophthalmitis / Q000209:etiology / Q000517:prevention & control*; D004797:Enzyme-Linked Immunosorbent Assay; D005337:Fibrin / Q000378:metabolism; D005500:Follow-Up Studies; D005549:Foreign-Body Reaction / Q000209:etiology / Q000517:prevention & control; D007910:Lenses, Intraocular; D008768:Methylmethacrylates / Q000378:metabolism*; D011183:Postoperative Complications / Q000209:etiology / Q000517:prevention & control*; D011817:Rabbits
D017304:Annexin A5; D008768:Methylmethacrylates; D005337:Fibrin