Glucocorticosteroids as immunosuppressive agents.
When administered at pharmacological dosages, glucocorticosteroid hormones alter leukocyte kinetics, phagocytic cell function, cell-mediated immunity, and, to a lesser extent, humoral immunity. These properties are used to advantage in the treatment of immunologically mediated disease. Corticosteroids are used to suppress pathological immune responses associated with autoimmunity, inhibit rejection of allogenic tissues after organ transplantation, and to diminish inflammation associated with a wide variety of hypersensitivity disorders. The mechanisms by which corticosteroids relieve these conditions are still not completely understood but have recently become more comprehensible. By understanding how corticosteroids exert their effects, we can make better clinical decisions in the management of immune-mediated disease.
Cohn
L A
LA
Department of Veterinary Medicine and Surgery, College of Veterinary Medicine, University of Missouri, Columbia 65211, USA.
D000818:Animals; D002371:Cat Diseases / Q000188:drug therapy*; D002415:Cats; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D005938:Glucocorticoids / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D007107:Immune System / Q000187:drug effects / Q000502:physiology; D007154:Immune System Diseases / Q000188:drug therapy / Q000662:veterinary*; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D007962:Leukocytes / Q000187:drug effects / Q000502:physiology; D010587:Phagocytosis / Q000187:drug effects / Q000502:physiology
D005938:Glucocorticoids; D007166:Immunosuppressive Agents