title: [The mechanisms of ET-1-induced lung edema].
abstract: OBJECTIVE
  To investigate the machanisms of ET-1-induced lung edema.
  
  
  METHODS
  Different doses of ET-1 were added to isolate rat lungs perfused by Ringer's solution containing albumin to explore the mechanisms of ET-1 induced pulmonary edema. The lung weight gain, pulmonary vascular permeability to water (Wf) and albumin (Ps) were observed.
  
  
  RESULTS
  It was found that low dose ET-1 increased lung weight gain, pulmonary artery pressure, pulmonary capillary pressure, pulmonary vascular post-resistance and total resistance, but no significant changes of vascular permeability were observed.
  
  
  CONCLUSIONS
  The mechanisms of lung edema induced by ET-1 are different. Low dose ET-1 may induce lung edema by increasing pulmonary vascular permeability while large dose ET-1 by increasing pulmonary vascular pressure.
authors.affiliation: Department of Anesthesiology, Changhai Hospital, Second Military Medical University, Shanghai.
authors.forename: N
authors.initials: N
authors.lastname: Hu
authors.forename: S
authors.initials: S
authors.lastname: Chen
authors.forename: B
authors.initials: B
authors.lastname: Yu
mesh_terms: D000818:Animals; D002199:Capillary Permeability; D019332:Endothelin-1; D066298:In Vitro Techniques; D008168:Lung / Q000098:blood supply; D008297:Male; D011654:Pulmonary Edema / Q000139:chemically induced* / Q000503:physiopathology; D051381:Rats; D017207:Rats, Sprague-Dawley; D014655:Vascular Resistance
chemical_list: D019332:Endothelin-1