The clinical and pathologic hallmarks of progressive supranuclear palsy.
This article reviews recent studies evaluating the clinicopathologic markers of progressive supranuclear palsy, which have helped establish standardized clinical and pathologic diagnostic criteria. Although these criteria increase diagnostic accuracy, the clinical and pathologic overlap between progressive supranuclear palsy and other disorders remains. Factors that may contribute toward managing progressive supranuclear palsy patients better are discussed and the etiopathogenicity of the disorder is hypothesized.
Litvan
I
I
Defense and Veterans Head Injury Program, Jackson Foundation, National Institutes of Health, Bethesda MD 20892-9130, USA. litvan1@helix.nih.gov
D015415:Biomarkers; D006801:Humans; D013494:Supranuclear Palsy, Progressive / Q000473:pathology*
D015415:Biomarkers