Immune reconstitution in HIV infection.
Progressive immune deficiency arising during HIV disease reflects the continual degradation and the ultimate deletion of immune specificites defined by the CD4(+) T lymphocyte repertoire. Recent evidence suggests that improvements in the immune function of patients with HIV who receive therapy primarily reflects the expansion of CD4(+) T lymphocyte populations present before therapy commenced. These observations have implications for clinical management, therapeutic strategies, and future research.
Emery
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National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, 2nd floor, 376 Victoria Street, Darlinghurst, Sydney, NSW 2010, Australia. semery@nchecr.unsw.edu.au
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D000163:Acquired Immunodeficiency Syndrome / Q000517:prevention & control; D019380:Anti-HIV Agents / Q000627:therapeutic use; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D005544:Forecasting; D006678:HIV / Q000502:physiology; D015658:HIV Infections / Q000188:drug therapy / Q000276:immunology*; D006801:Humans; D007121:Immunocompetence; D018448:Models, Immunological; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D014779:Virus Replication
D019380:Anti-HIV Agents