Quinine may trigger torsades de pointes during astemizole therapy.
Because of serious cardiovascular events, warnings against concomitant use of certain medications with the use of antihistamine (HismanalR have been published and added to product labeling. Quinine, the optical isomer to quinidine, is included in these warnings. We present the case of a patient with only mild electrolyte disturbances who experienced an episode of torsades de pointes after a single dose of quinine while taking astemizole.
Martin
E S
ES
University of Texas at Austin College of Pharmacy, USA.
Rogalski
K
K
Black
J N
JN
D000328:Adult; D018926:Anti-Allergic Agents / Q000627:therapeutic use*; D016589:Astemizole / Q000627:therapeutic use*; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D005260:Female; D006634:Histamine H1 Antagonists / Q000627:therapeutic use*; D006801:Humans; D009125:Muscle Relaxants, Central / Q000009:adverse effects*; D011803:Quinine / Q000009:adverse effects*; D016171:Torsades de Pointes / Q000139:chemically induced*
D018926:Anti-Allergic Agents; D006634:Histamine H1 Antagonists; D009125:Muscle Relaxants, Central; D016589:Astemizole; D011803:Quinine