title: 131I dose-dependent thyroid autoimmune disorders in children living around Chernobyl.
abstract: We assessed the major lymphocyte subsets in the peripheral blood, thyroid ultrasonography, levels of serum autoantibodies to thyroglobulin (AbTg), thyroid hormones, and thyroid-stimulating hormone (TSH) in 53 children without any chronic diseases living continuously around Chernobyl. The subjects ranged in age from 7 to 14 years and had different doses of 131I to their thyroid. Healthy children living on noncontaminated areas were assessed as controls. The majority of children with doses of 131I had normal levels of thyroid hormones. However, the percentages of positive sera for AbTg, TSH levels, ultrasonographic thyroid abnormalities, and abnormal echogenicity were significantly higher in children with doses of 131I than in controls. The dose of 131I to thyroid correlated positively with serum AbTg levels, percentage of CD3+CD4+ cells, and CD3+CD4+/CD3+CD8+ cell ratio and negatively with number of CD3+CD8+ and CD3-/CD16, CD56+ cells. Thus, our study demonstrates an association between dose of 131I and autoimmune thyroid disorders in this population of children.
authors.affiliation: Laboratory of Immunology, Institute of Pediatrics, Obstetrics and Gynecology, Kiev, Ukraine.
authors.forename: E V
authors.initials: EV
authors.lastname: Vykhovanets
authors.forename: V P
authors.initials: VP
authors.lastname: Chernyshov
authors.forename: I I
authors.initials: II
authors.lastname: Slukvin
authors.forename: Y G
authors.initials: YG
authors.lastname: Antipkin
authors.forename: A N
authors.initials: AN
authors.lastname: Vasyuk
authors.forename: H F
authors.initials: HF
authors.lastname: Klimenko
authors.forename: K W
authors.initials: KW
authors.lastname: Strauss
mesh_terms: D000293:Adolescent; D001323:Autoantibodies / Q000097:blood; D001327:Autoimmune Diseases / Q000209:etiology*; D002648:Child; D006801:Humans; D007457:Iodine Radioisotopes / Q000009:adverse effects*; D018655:Lymphocyte Count; D016131:Lymphocyte Subsets / Q000737:chemistry / Q000276:immunology; D011847:Radioactive Fallout; D018788:Radioactive Hazard Release; D011848:Radioactive Pollutants / Q000009:adverse effects; D013954:Thyroglobulin / Q000276:immunology; D013959:Thyroid Diseases / Q000276:immunology*; D013961:Thyroid Gland / Q000000981:diagnostic imaging; D013963:Thyroid Hormones / Q000097:blood; D013972:Thyrotropin / Q000097:blood; D014455:Ukraine; D014463:Ultrasonography
chemical_list: D001323:Autoantibodies; D007457:Iodine Radioisotopes; D011847:Radioactive Fallout; D011848:Radioactive Pollutants; D013963:Thyroid Hormones; D013972:Thyrotropin; D013954:Thyroglobulin