Preparation and composition of acellular pertussis vaccines. Consideration of potential effects on vaccine efficacy.
An evaluation of possible relationships between the preparation and content of acellular pertussis vaccines and their efficacy reveals that, in most instances, there is much more extensive variability in content and mode of preparation of these products than in their clinical efficacies. In general, there is a positive correlation of antigen content with immunogenicity. However, there was an apparent difference in the dose-response relationships between chemically and genetically toxoided vaccines which revealed a greater immunogenicity of the genetically inactivated material. Overall, however, the immunigenicity data (IgG serology) do not correlate well with protective efficacy and it is apparent that additional information is necessary to elucidate a specific role for any aspect of vaccine content or preparation in vaccine efficacy.
Hewlett
E L
EL
Department of Medicine, University of Virgina, Charlottesville, USA.
D000818:Animals; D000907:Antibodies, Bacterial / Q000096:biosynthesis; D000942:Antigens, Bacterial / Q000276:immunology; D002986:Clinical Trials as Topic; D015721:Diphtheria-Tetanus-Pertussis Vaccine / Q000737:chemistry / Q000276:immunology*; D022681:Diphtheria-Tetanus-acellular Pertussis Vaccines; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007223:Infant; D010566:Virulence Factors, Bordetella / Q000737:chemistry / Q000276:immunology; D014917:Whooping Cough / Q000276:immunology / Q000517:prevention & control
D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D015721:Diphtheria-Tetanus-Pertussis Vaccine; D022681:Diphtheria-Tetanus-acellular Pertussis Vaccines; D010566:Virulence Factors, Bordetella