title: Treatment of a dog with an insulinoma-related peripheral polyneuropathy with corticosteroids.
abstract: A crossbreed dog with a history of a chronic progressive tetraparesis had an insulinoma-related peripheral polyneuropathy. Frequent feeding and treatment with corticosteroids resulted in recovery from a non-ambulatory to an almost completely normal clinical state, despite the persistence of hypoglycaemia and hyperinsulinism. After euthanasia for uncontrollable seizures, the presence of a beta-cell carcinoma of the pancreas and extensive axonal degeneration of the peripheral nerves was confirmed by histopathological examination. These findings may indicate an immune-mediated pathogenesis for insulinoma-related peripheral polyneuropathy.
authors.affiliation: Department of Small Animal Medicine and Clinical Biology, University of Gent, Belgium.
authors.forename: L
authors.initials: L
authors.lastname: Van Ham
authors.forename: K G
authors.initials: KG
authors.lastname: Braund
authors.forename: S
authors.initials: S
authors.lastname: Roels
authors.forename: I
authors.initials: I
authors.lastname: Putcuyps
mesh_terms: D000818:Animals; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use*; D004283:Dog Diseases / Q000175:diagnosis / Q000628:therapy*; D004285:Dogs; D007340:Insulinoma / Q000150:complications / Q000628:therapy / Q000662:veterinary*; D008297:Male; D010190:Pancreatic Neoplasms / Q000150:complications / Q000628:therapy / Q000662:veterinary*; D010523:Peripheral Nervous System Diseases / Q000209:etiology / Q000662:veterinary*; D011239:Prednisolone / Q000627:therapeutic use*
chemical_list: D018931:Antineoplastic Agents, Hormonal; D011239:Prednisolone