title: [The typical radiological findings and course of invasive pulmonary aspergillosis in the immunosuppressed patient].
abstract: OBJECTIVE
  This retrospective study was designed to show whether invasive pulmonary aspergillosis, which is often difficult to diagnose by bronchoscopy or serology, can be diagnosed at an early stage by typical radiological findings on conventional radiographs or by CT, specially high resolution CT (HR-CT).
  
  
  METHODS
  In 19 Patients with 20 disease episodes, 20 thorax radiographs and eight spiral CT examinations were performed and in four cases HR-CT was also available. The earliest pathological findings and the course of the disease were analysed and the results of the various examinations were compared.
  
  
  RESULTS
  90% of chest examinations, including CT and HR-CT, showed the following lesions as part of the earliest changes: round or wedge-shaped opacities or the so-called "halo" sign. CT or HR-CT always demonstrated more lesions than plain chest radiographs; 75% of lesions appeared typical and thereby contributed to the diagnosis.
  
  
  CONCLUSIONS
  The typical radiological findings of round or wedge-shaped opacities and the so-called "halo" sign are additional criteria for the diagnosis of invasive pulmonary aspergillosis. The superiority of CT or HR-CT in the demonstration of pathological changes suggests that these should be used early in the investigation of patients who are specially at risk.
authors.affiliation: Radiologische Universitätsklinik Bonn.
authors.forename: C
authors.initials: C
authors.lastname: Leutner
authors.forename: H
authors.initials: H
authors.lastname: Strunk
authors.forename: H
authors.initials: H
authors.lastname: Müller-Miny
authors.forename: S
authors.initials: S
authors.lastname: Ewig
authors.forename: A
authors.initials: A
authors.lastname: Glasmacher
authors.forename: C
authors.initials: C
authors.lastname: Losem
authors.forename: E
authors.initials: E
authors.lastname: Molitor
authors.forename: H H
authors.initials: HH
authors.lastname: Schild
mesh_terms: D000328:Adult; D000368:Aged; D001228:Aspergillosis / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D016867:Immunocompromised Host; D008168:Lung / Q000000981:diagnostic imaging*; D008172:Lung Diseases, Fungal / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D013902:Radiography, Thoracic / Q000379:methods; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed / Q000379:methods