Minibrain (MNBH) is a single copy gene mapping to human chromosome 21q22.2.
We have identified a human homologue of the Drosophila mnb gene (MNBH) on chromosome 21, while another study mapped an EST clone (R38268) with similarity to minibrain to human chromosome 1. This report describes the mapping of MNBH to a single locus on human chromosome 21q22.2 by FISH and Southern blotting. Comparison of the similarities between the two sequences and mnb demonstrates that MNBH on chromosome 21 is the true human homologue of Drosophila mnb.
Guimera
J
J
Molecular Genetics Department, L'Hospitalet de Llobregat, Barcelona, Catalonia, Spain.
Pritchard
M
M
Nadal
M
M
Estivill
X
X
D000595:Amino Acid Sequence; D000818:Animals; D002874:Chromosome Mapping; D002891:Chromosomes, Human, Pair 21 / Q000235:genetics*; D004330:Drosophila / Q000235:genetics; D029721:Drosophila Proteins; D015870:Gene Expression; D017344:Genes, Insect; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008969:Molecular Sequence Data; D017346:Protein Serine-Threonine Kinases / Q000235:genetics*; D011505:Protein-Tyrosine Kinases; D017386:Sequence Homology, Amino Acid; D013045:Species Specificity; D000097603:Dyrk Kinases
D029721:Drosophila Proteins; D017346:Protein Serine-Threonine Kinases; D011505:Protein-Tyrosine Kinases; D000097603:Dyrk Kinases; C092066:mnb protein, Drosophila