title: Effects of visceral fat and weight loss on lipoprotein(a) concentration in subjects with obesity.
abstract: We studied the relationships between regional body fat distribution and metabolic variables with lipoprotein(a) [Lp(a)] as well as the effects of weight loss on Lp(a) in 25 women and 9 men with obesity. Regional body fat distribution, as evaluated by the use of computed tomography; Lp(a); and fasting glucose, insulin, cholesterol, and triglycerides were analyzed before and after a very low-energy diet. No significant correlations were found between visceral, subcutaneous, and total fat and Lp(a) or between metabolic variables and Lp(a). All anthropometric variables significantly decreased after a very low-energy diet. Fasting glucose, insulin, triglycerides, and cholesterol significantly decreased after a very low-energy diet. No significant changes in Lp(a) concentration after a very low-energy diet were found. The correlation between the initial values of Lp(a) and changes of Lp(a) after a very low-energy diet was slightly significant (rho = 0.33, p < 0.06). In conclusion, our study shows that Lp(a) is not influenced by obesity, visceral fat, metabolic variables, or weight loss induced by a very low-energy diet.
authors.affiliation: University of Verona, Policlinic of Borgo Roma, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Zamboni
authors.forename: R
authors.initials: R
authors.lastname: Facchinetti
authors.forename: F
authors.initials: F
authors.lastname: Armellini
authors.forename: E
authors.initials: E
authors.lastname: Turcato
authors.forename: I A
authors.initials: IA
authors.lastname: Bergamo Andreis
authors.forename: O
authors.initials: O
authors.lastname: Bosello
mesh_terms: D000273:Adipose Tissue; D001823:Body Composition; D015992:Body Mass Index; D004038:Diet, Reducing; D002149:Energy Intake; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood; D017270:Lipoprotein(a) / Q000097:blood*; D008297:Male; D009765:Obesity / Q000097:blood* / Q000178:diet therapy; D014057:Tomography, X-Ray Computed; D014781:Viscera; D015431:Weight Loss
chemical_list: D008055:Lipids; D017270:Lipoprotein(a)