Evaluation of bedside prothrombin time and activated partial thromboplastin time measurement by coagulation analyzer CoaguCheck Plus in various clinical settings.
In the present study CoaguCheck Plus (CCP), a coagulation test system using whole blood, was evaluated with respect to its comparability with widely distributed conventional routine coagulation assays. A correlation of r = 0.997 (p < 0.0001) was found between INR of CCP-prothrombin time (CCP-PT) and Thrombotest (KC-1 analyzer) in patients on oral anticoagulant therapy. A correlation of r = 0.899 (p < 0.001) between CCP-aPTT and Actin ES aPTT (STA analyzer) was found in heparinized patients. Impaired hepatic hepatic coagulation factor synthesis in liver cirrhosis patients was detected by CCP-PT with a sensitivity of 0.75 and by Normotest (STA analyzer) with a sensitivity of 0.92. Those patients with normal CCP-PT values and liver disease had, only mild reductions (> 30% of normals) in coagulation factors II, V, VII or X. CCP-aPTT was also performed in patients with a deficiency in the so called endogenous coagulation factors VIII, IX, XI and XII. CCP-aPTT showed a sensitivity similar to that of Actin FS aPTT in the detection even of mild deficiencies in factors VIII, IX and XII; factor XI deficiency was however detected only in patients with severe (< 12% of normals) disease; lupus anticoagulants were detected with a high sensitivity.
Ruzicka
K
K
Clinical Institute of Medical and Chemical Laboratory Diagnostics, University of Vienna, Austria.
Kapiotis
S
S
Quehenberger
P
P
Handler
S
S
Hornykewycz
S
S
Michitsch
A
A
Huber
K
K
Clemens
D
D
Susan
M
M
Pabinger
I
I
Eichinger
S
S
Jilma
B
B
Speiser
W
W
D001780:Blood Coagulation Tests / Q000295:instrumentation*; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D007202:Indicators and Reagents; D008111:Liver Function Tests; D016682:Lupus Coagulation Inhibitor / Q000032:analysis; D010314:Partial Thromboplastin Time; D019095:Point-of-Care Systems; D011517:Prothrombin Time; D012016:Reference Values; D012680:Sensitivity and Specificity
D007202:Indicators and Reagents; D016682:Lupus Coagulation Inhibitor; D006493:Heparin