Membrane rearrangements in fusion mediated by viral proteins.
Diverse enveloped viruses enter host cells by fusing their envelopes with cell membranes. The mechanisms of merger of lipid bilayers of two membranes mediated by influenza hemagglutinin and other viral fusion proteins apparently involve local lipidic connections that evolve into a bilayer septum in which a pore forms and expands.
Melikyan
G B
GB
Dept of Molecular Biophysics and Physiology, Rush Medical College, Chicago, IL 60612, USA. gmelikia@rpslmc.edu
Chernomordik
L V
LV
D002462:Cell Membrane / Q000378:metabolism* / Q000821:virology*; D002478:Cells, Cultured; D019267:Hemagglutinin Glycoproteins, Influenza Virus / Q000378:metabolism*; D050356:Lipid Metabolism; D008954:Models, Biological; D018272:Porins / Q000378:metabolism; D014760:Viral Fusion Proteins / Q000378:metabolism; D014764:Viral Proteins / Q000378:metabolism / Q000502:physiology
D019267:Hemagglutinin Glycoproteins, Influenza Virus; D018272:Porins; D014760:Viral Fusion Proteins; D014764:Viral Proteins