Prophylaxis of experimental HTLV-I infection in cynomolgus monkeys by passive immunization.
The protective effect of purified human immunoglobulin against human T-cell leukaemia virus type I (HTLV-I), designated ATLIG on HTLV-I infection was examined in cynomolgus monkeys (Macaca fascicularis) as a preclinical study. Passive immunization of ATLIG 24 h before challenging HTLV-I protected the monkeys from HTLV-I infection. The result suggests that passive immunization of ATLIG could provide safe and sufficient protection against HTLV-I infection in humans.
Akari
H
H
Tsukuba Primate Center for Medical Science, National Institute of Health, Ibaraki, Japan.
Suzuki
T
T
Ikeda
K
K
Hoshino
H
H
Tomono
T
T
Murotsuka
T
T
Terao
K
K
Ito
H
H
Yoshikawa
Y
Y
D000818:Animals; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D015490:HTLV-I Infections / Q000517:prevention & control*; D007116:Immunization, Passive; D008252:Macaca fascicularis; D008297:Male
D004279:DNA, Viral