Genetic heterogeneity of migraine with and without aura in Danes cannot be explained by mutation in mtDNA nucleotide pair 11084.
BACKGROUND
Migraine is a genetic heterogeneous disorder. The 11084 A to G base substitution is in the gene for the ND4 subunit of the respiratory complex I, and leads to a Thr to Ala amino acid replacement. This mutation had been found in 25% of Japanese migraineurs, while tension-type headache sufferers and non-migraineurs did not have it.


METHODS
We investigated the importance of this mutation in Danish migraineurs without aura, migraineurs with aura and non-migraineurs from the general population.


RESULTS
We did not detect this mutation in Danes.


CONCLUSIONS
Our result excludes a significant role of this mutation in the etiology of migraine in Denmark, and its absence in non-migraineurs supports that this mutation is rare in non-Japanese populations.
Russell
M B
MB
Department of Neurology, Glostrup Hospital, University of Copenhagen, Denmark.
Diamant
M
M
Nørby
S
S
D000328:Adult; D001482:Base Composition / Q000235:genetics; D004252:DNA Mutational Analysis; D004272:DNA, Mitochondrial / Q000235:genetics*; D003718:Denmark; D005260:Female; D005828:Genetics, Population; D006801:Humans; D008297:Male; D008881:Migraine Disorders / Q000235:genetics*; D009710:Nucleotide Mapping; D016133:Polymerase Chain Reaction
D004272:DNA, Mitochondrial