Pore-forming proteins in pathogenic protozoan parasites.
Pore-forming proteins (PFPs) may play important roles in pathogenesis by protozoan parasites by either directly damaging the plasma membrane of the host cells or ensuring intracellular survival of the parasites by promoting their exit from lysosomal vacuoles. The Leishmania amazonensis pore-forming cytolysin, leishporin, may play a crucial role in the pathogenesis of leishmaniasis.
Horta
M F
MF
Dept de Bioquimica e Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil. phorta@icb.ufmg.br
D000818:Animals; D002462:Cell Membrane / Q000378:metabolism; D056890:Eukaryota / Q000472:pathogenicity*; D006790:Host-Parasite Interactions; D006801:Humans; D008247:Lysosomes / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D018272:Porins / Q000378:metabolism*; D011528:Protozoan Infections / Q000378:metabolism*; D015800:Protozoan Proteins / Q000378:metabolism*
D018272:Porins; D015800:Protozoan Proteins