B cell-deficient muMT mice as an experimental model for Mycoplasma infections in X-linked agammaglobulinemia.
B cell-deficient muMT mice were investigated as an experimental model for human X-linked agammaglobulinemia (XLA). Mice were intranasally infected with Mycoplasma pulmonis and in 16 out of 17 muMT mice, dissemination of the bacteria from the airways was observed. More than 50% of these mice developed arthritis and/or changes in periarticular tissues. Mycoplasmal infection in muMT mice thus resembles the disease seen in XLA patients implying the usefulness of the model.
Berglöf
A
A
Department of Immunology, Microbiology, Pathology, and Infectious Diseases, Karolinska Institute, Huddinge Hospital, Sweden.
Sandstedt
K
K
Feinstein
R
R
Bölske
G
G
Smith
C I
CI
D000361:Agammaglobulinemia / Q000150:complications* / Q000235:genetics* / Q000276:immunology; D000818:Animals; D001170:Arthritis, Infectious / Q000209:etiology / Q000473:pathology; D001402:B-Lymphocytes / Q000276:immunology; D004195:Disease Models, Animal; D005260:Female; D008040:Genetic Linkage; D006801:Humans; D007148:Immunoglobulin mu-Chains / Q000235:genetics; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D009175:Mycoplasma Infections / Q000209:etiology* / Q000473:pathology; D014960:X Chromosome / Q000235:genetics*
D007148:Immunoglobulin mu-Chains