[The effect of verapamil on cardio- and hemodynamics in rats with various models of hypertension].
Rats with various models of hypertension (spontaneous, renal, neurogenic, adreno-regenerative) were used in experiments to study the effect of verapamil on parameters of cardio- and hemodynamics in its two-week oral administration. The antihypertensive effect of verapamil was most expressed in rats with spontaneous model of hypertension and initial hyperkinetic variant of circulation.
Spasov
A A
AA
Gurbanov
K G
KG
Seredintseva
N V
NV
Paperno
A A
AA
D000284:Administration, Oral; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002121:Calcium Channel Blockers / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004569:Electroencephalography; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D006977:Hypertension, Renal / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D051381:Rats; D011918:Rats, Inbred SHR; D012079:Renal Circulation / Q000187:drug effects; D014655:Vascular Resistance / Q000187:drug effects; D014664:Vasodilation / Q000187:drug effects; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D014700:Verapamil / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*
D002121:Calcium Channel Blockers; D014665:Vasodilator Agents; D014700:Verapamil