title: Killing kinetics of RP 59500 and pristinamycin against penicillin-resistant pneumococci.
abstract: The killing kinetics of two streptogramins, RP 59500 and pristinamycin against seventeen isolates of penicillin-susceptible and resistant pneumococci were studied. The antibiotics were tested at 1x, 2x and 4x the MIC for each individual isolate. The results showed a very good and rapid bactericidal activity within 1 hour for concentrations equal or greater to the MIC. These antibiotics are very promising agents for the treatment of infections due to multiresistant pneumococci.
authors.affiliation: CHU Saint-Antoine, Laboratoire de Bactériologie-Virologie, Paris, France.
authors.forename: V
authors.initials: V
authors.lastname: Barakett
authors.forename: D
authors.initials: D
authors.lastname: Lesage
authors.forename: F
authors.initials: F
authors.lastname: Delisle
authors.forename: G
authors.initials: G
authors.lastname: Richard
authors.forename: J C
authors.initials: JC
authors.lastname: Petit
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D018432:Drug Resistance, Multiple; D066298:In Vitro Techniques; D007700:Kinetics; D008826:Microbial Sensitivity Tests; D010403:Penicillin Resistance; D013296:Streptococcus pneumoniae / Q000187:drug effects*; D014769:Virginiamycin / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D014769:Virginiamycin; C062940:quinupristin-dalfopristin