[Leukocyte filtration in elective colorectal surgery. Reduced transfusion associated immunosuppression after bedside procedures].
The objective of the study was to investigate certain immune parameters in patients undergoing elective colorectal surgery and receiving either whole blood transfusion or leucocyte-filtrated blood. Sixty consecutive patients were randomly allocated to receive either whole blood transfusion or leucocyte-filtrated blood leucocyte when transfusion was indicated. The immune parameters were investigated on the day of surgery and on day 3, 7 and 30 postoperatively. Transfusion with whole blood was followed by a significant decrease in lymphocyte proliferation and CD4+/CD8+ ratio (p < 0.01) as well as a significant increase in soluble interleukin-2 receptor and interleukin-6 (p < 0.01). Furthermore transfusion with whole blood was accompanied by a significant increase in postoperative infectious complications (p < 0.01). Patients transfused with leucocyte-filtrated blood had only minor and passing changes in the immune parameters and developed no infectious complications, indicating that effective leucocyte filtration abolishes transfusion-associated immunosuppression.
Jensen
L S
LS
Arhus Universitetshospital, Arhus Kommunehospital, kirurgisk gastroenterologisk afdeling L.
Hokland
M E
ME
Nielsen
H J
HJ
D000328:Adult; D000368:Aged; D016516:CD4-CD8 Ratio; D003108:Colonic Diseases / Q000601:surgery*; D017558:Elective Surgical Procedures; D005260:Female; D006801:Humans; D007108:Immune Tolerance; D007958:Leukocyte Count; D018655:Lymphocyte Count; D008212:Lymphocyte Depletion; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000276:immunology; D011446:Prospective Studies; D018123:Receptors, Interleukin / Q000276:immunology; D015375:Receptors, Interleukin-2 / Q000276:immunology; D012002:Rectal Diseases / Q000601:surgery*; D065227:Transfusion Reaction
D018123:Receptors, Interleukin; D015375:Receptors, Interleukin-2