Carvedilol for heart failure: renewed interest in beta blockers.
Although beta blockers were once contraindicated in patients with heart failure, a growing understanding of the role of the sympathetic nervous system in heart failure is rekindling interest in these drugs. In particular, the beta blocker carvedilol is a valuable adjunctive treatment for mild-to-moderate compensated congestive heart failure, regardless of etiology. The utility of carvedilol appears to be related to its specific properties.
Young
J B
JB
Department of Cardiology, Cleveland Clinic, USA. youngj@cesmtp.ccf.org
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology / Q000627:therapeutic use*; D002227:Carbazoles / Q000494:pharmacology / Q000627:therapeutic use*; D000077261:Carvedilol; D002986:Clinical Trials as Topic; D006333:Heart Failure / Q000188:drug therapy* / Q000401:mortality; D006801:Humans; D011412:Propanolamines / Q000494:pharmacology / Q000627:therapeutic use*
D000319:Adrenergic beta-Antagonists; D002227:Carbazoles; D011412:Propanolamines; D000077261:Carvedilol