title: Correlation of histologic subtypes of primary basal cell carcinoma and number of Mohs stages required to achieve a tumor-free plane.
abstract: BACKGROUND
  Certain histologic subtypes of basal cell carcinoma (BCC) behave more aggressively and require more aggressive treatment.
  
  
  OBJECTIVE
  The aim of this study was to see whether certain subtypes of BCC require more Mohs stages to achieve tumor-free margins.
  
  
  METHODS
  A retrospective study of 342 primary BCCs treated with Mohs micrographic surgery (MMS) was performed identifying the histologic subtype of BCC present and the number of stages required to clear the tumor.
  
  
  RESULTS
  The aggressive subtypes (infiltrative, morpheaform, micronodular, and mixed) were most frequently found when high numbers of Mohs stages were required for cure.
  
  
  CONCLUSIONS
  The more aggressive subtypes of BCC require more MMS stages to achieve tumor-free margins, which is consistent with the concept that these subtypes usually require more aggressive treatment from the start.
authors.affiliation: Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: I F
authors.initials: IF
authors.lastname: Orengo
authors.forename: S J
authors.initials: SJ
authors.lastname: Salasche
authors.forename: J
authors.initials: J
authors.lastname: Fewkes
authors.forename: J
authors.initials: J
authors.lastname: Khan
authors.forename: J
authors.initials: J
authors.lastname: Thornby
authors.forename: F
authors.initials: F
authors.lastname: Rubin
mesh_terms: D000368:Aged; D002280:Basal Cell Carcinoma / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D008297:Male; D015580:Mohs Surgery; D012189:Retrospective Studies; D012878:Skin Neoplasms / Q000473:pathology* / Q000601:surgery