Paracetamol poisoning in the north east of England: presentation, early management and outcome.
1. Paracetamol is increasingly involved in self-poisoning in the United Kingdom and remains a common cause of fatal poisoning. 2. To document the epidemiology and early management of paracetamol poisoning data were collected on consecutive patients with suspected paracetamol poisoning presenting to 6 hospitals in the North East of England over 12 weeks in 1994. 3. There were 400 presentations (attendance rate 1.14/10(3) population/yr) involving 343 persons (45% male). Paracetamol concentrations at 4 h correlated weakly with reported paracetamol dose (R = 0.49, P < 0.0001) and were similar comparing those treated and not treated by gastric decontamination. 4. In 38 (9%) cases paracetamol concentrations were above the appropriate nomogram treatment line, including 3% and 20% of patients who reported ingesting less than and more than 12 g respectively. In 21 patients acetylcysteine treatment was deferred until admission to the ward, the mean delay involved was 2.8 h. 5. One patient died, from arrhythmias caused by co-ingested dothiepin. 6. Paracetamol poisoning is common. Most cases do not have potentially toxic plasma paracetamol concentrations, but those who do often present late and antidotal treatment may be delayed inappropriately.
Thomas
S H
SH
Wolfson Unit of Clinical Pharmacology, University of Newcastle upon Tyne, UK.
Horner
J E
JE
Chew
K
K
Connolly
J
J
Dorani
B
B
Bevan
L
L
Bhattacharyya
S
S
Bramble
M G
MG
Han
K H
KH
Rodgers
A
A
Sen
B
B
Tesfayohannes
B
B
Wynne
H
H
Bateman
D N
DN
D000082:Acetaminophen / Q000493:pharmacokinetics / Q000506:poisoning*; D000293:Adolescent; D000328:Adult; D000368:Aged; D018712:Analgesics, Non-Narcotic / Q000493:pharmacokinetics / Q000506:poisoning*; D000931:Antidotes; D002606:Charcoal / Q000627:therapeutic use; D002648:Child; D004739:England / Q000453:epidemiology; D005260:Female; D005751:Gastric Lavage; D006801:Humans; D008297:Male; D008875:Middle Aged; D011041:Poisoning / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy*; D016896:Treatment Outcome
D018712:Analgesics, Non-Narcotic; D000931:Antidotes; D002606:Charcoal; D000082:Acetaminophen