title: Effect on infant mortality of iodination of irrigation water in a severely iodine-deficient area of China.
abstract: BACKGROUND
  Hotien county in Xinjiang province, China, is an area of severe iodine deficiency and has a high infantmortality rate. We investigated whether iodine replacement through iodination of the irrigation water would decrease infant mortality.
  
  
  METHODS
  We added potassium iodate to irrigation water over a 2 to 4 week period beginning in 1992 in certain areas of three townships (Tusala, Long Ru, and Bakechi). Logistic regression analysis was used to compare the odds ratios for infant and neonatal mortality in treated and intreated areas.
  
  
  RESULTS
  The median urinary iodine concentration significantly increased in women of child-bearing age from < 10 micrograms/L to 55 micrograms/L. Infant-mortality rates decreased in the treated areas of Long Ru (mean [SD] 58.2 [4.4] per 1000 births to 28.7 [7.1] per 1000 births), Tusala (47.4 [12.4] per 1000 births to 19.1 [1.5] per 1000 births), and Bakechi (106.2 [9.5] per 1000 births to 57.3 [7.3] per 1000 births). Similar results were also seen for neonatal mortality. On regression analysis iodine treatment and time were significant independent predictors of infant mortality.
  
  
  CONCLUSIONS
  Iodine supplementation of irrigation water in areas of severe iodine deficiency decreases neonatal and infant mortality. Iodine replacement has probably been an important factor in the national decrease in infant mortality in China.
authors.affiliation: Division of Pediatric Neurology, Duke University Medical Center, Durham NC 27710, USA.
authors.forename: G R
authors.initials: GR
authors.lastname: DeLong
authors.forename: P W
authors.initials: PW
authors.lastname: Leslie
authors.forename: S H
authors.initials: SH
authors.lastname: Wang
authors.forename: X M
authors.initials: XM
authors.lastname: Jiang
authors.forename: M L
authors.initials: ML
authors.lastname: Zhang
authors.forename: M
authors.initials: M
authors.lastname: Rakeman
authors.forename: J Y
authors.initials: JY
authors.lastname: Jiang
authors.forename: T
authors.initials: T
authors.lastname: Ma
authors.forename: X Y
authors.initials: XY
authors.lastname: Cao
mesh_terms: D000328:Adult; D000383:Agriculture; D002681:China / Q000453:epidemiology; D005260:Female; D006801:Humans; D007223:Infant; D007226:Infant Mortality; D007231:Infant, Newborn; D007452:Iodates; D007455:Iodine / Q000172:deficiency* / Q000652:urine; D017680:Potassium Compounds; D011247:Pregnancy; D012044:Regression Analysis; D012423:Rural Health; D014881:Water Supply
chemical_list: D007452:Iodates; D017680:Potassium Compounds; D007455:Iodine; C039693:potassium iodate