title: Increased granulocyte aggregation in vitro in diabetes mellitus.
abstract: Having previously shown an increase in white blood cell (WBC) aggregation in groups known to have a high incidence of cardiovascular events, we compared 28 patients with diabetes mellitus and no history or clinical evidence of macrovascular disease with 28 age- and sex-matched normal controls. Patients and controls had blood taken in the morning and analysed for WBC aggregation in vitro using a whole blood technique. WBC aggregation was significantly higher in the diabetic group compared with the normal controls (mean +/- SD 31.10 +/- 10.26% vs. 25.7 +/- 9.38%; p < 0.04, Student t-test). WBC aggregation predates the appearance of clinical symptoms of macrovascular disease in diabetes.
authors.affiliation: University Department of Medicine, Ninewells Hospital and Medical School, Dundee, UK.
authors.forename: T A
authors.initials: TA
authors.lastname: Elhadd
authors.forename: A
authors.initials: A
authors.lastname: Bancroft
authors.forename: M
authors.initials: M
authors.lastname: McLaren
authors.forename: R W
authors.initials: RW
authors.lastname: Newton
authors.forename: J J
authors.initials: JJ
authors.lastname: Belch
mesh_terms: D000368:Aged; D002449:Cell Aggregation; D018929:Cell Culture Techniques; D003920:Diabetes Mellitus / Q000097:blood*; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006098:Granulocytes / Q000502:physiology*; D006801:Humans; D008214:Lymphocytes / Q000502:physiology; D008297:Male; D008875:Middle Aged
chemical_list: D006442:Glycated Hemoglobin