Potentiation by its esterification of the inhibitory action of 2-deoxy-D-glucose on D-glucose metabolism and insulinotropic action.
It was recently reported that selected esters of D-glucose are more efficiently metabolized and display a greater insulinotropic action in pancreatic islets than the unesterified hexose. Likewise, in the present study, the inhibitory action of 2-deoxy-D-glucose tetraacetate upon D-glucose metabolism in rat erythrocytes and pancreatic islets was found to be more pronounced than that of unesterified 2-deoxy-D-glucose. At a concentration of 10 mM, the ester also inhibited more severely than unesterified 2-deoxy-D-glucose the release of insulin evoked by D-glucose in isolated islets. It is proposed that 2-deoxy-D-glucose tetraacetate represents a useful tool to facilitate the intracellular delivery of the glucose analog and to increase its efficiency as a potential therapeutic agent.
Vanhoutte
C
C
Laboratory of Experimental Medicine, Brussels Free University, Belgium.
Kadiata
M M
MM
Sener
A
A
Malaisse
W J
WJ
D000818:Animals; D003847:Deoxyglucose / Q000031:analogs & derivatives / Q000494:pharmacology*; D004912:Erythrocytes / Q000378:metabolism; D004951:Esterification; D005260:Female; D005947:Glucose / Q000378:metabolism*; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
D007328:Insulin; D003847:Deoxyglucose; D005947:Glucose