Childhood laterality and later risk of schizophrenia in the 1946 British birth cohort.
An increased rate on non-righthandedness and other abnormalities of lateralization have been reported in schizophrenia. We investigated childhood hand preference and eye dominance as risk factors for adult schizophrenia among a general population birth cohort. Pre-schizophrenic children showed a significant excess of left-eye dominance at age 11 when compared with controls (OR 2.5, 1.0-5.8, p = 0.03), but there was no significant difference in hand preference between pre-schizophrenic children and controls.
Cannon
M
M
Department of Psychological Medicine and Social, Institute of Psychiatry, London, UK.
Jones
P
P
Murray
R M
RM
Wadsworth
M E
ME
D001921:Brain / Q000503:physiopathology*; D002648:Child; D015331:Cohort Studies; D005260:Female; D007839:Functional Laterality; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012559:Schizophrenia / Q000503:physiopathology*; D006113:United Kingdom