title: Evolution of human immunodeficiency virus subtype A in women seroconverting post partum and in their offspring post-natally infected by ingestion of breast milk.
abstract: The evolution of genomic RNA of human immunodeficiency virus type 1 (HIV-1), subtype A, was studied in three Rwandan mother-child pairs over a period of 12-30 months. In two pairs a homogeneous subtype A V3 sequence population was observed at seroconversion and the virus populations in the children resembled those in the mothers. One of these mother-child pairs was infected with an A/C recombinant virus (Ap17/Cp24). In the third pair, a heterogeneous V3 sequence population was observed in the maternal seroconversion sample but the V3 sequence population in the child's sample was homogeneous. In each individual the intra- and intersample variation (between the seroconversion and follow-up samples) increased over time in both the V3 region and p17gag. Independent evolution for 1-2 years did not abolish the epidemiological relationship between virus populations in mother and child.
authors.affiliation: AIDS Reference Laboratory, National AIDS Control Program, Kigali, Rwanda.
authors.forename: A
authors.initials: A
authors.lastname: Simonon
authors.forename: G A
authors.initials: GA
authors.lastname: Mulder-Kampinga
authors.forename: P
authors.initials: P
authors.lastname: van de Perre
authors.forename: E
authors.initials: E
authors.lastname: Karita
authors.forename: P
authors.initials: P
authors.lastname: Msellati
authors.forename: C
authors.initials: C
authors.lastname: Kuiken
authors.forename: J
authors.initials: J
authors.lastname: Goudsmit
mesh_terms: D000595:Amino Acid Sequence; D019143:Evolution, Molecular; D005260:Female; D015683:Gene Products, gag / Q000235:genetics; D014644:Genetic Variation / Q000235:genetics; D015488:HIV Antigens / Q000235:genetics; D015699:HIV Envelope Protein gp120 / Q000235:genetics; D015658:HIV Infections / Q000635:transmission* / Q000821:virology*; D015497:HIV-1 / Q000235:genetics*; D006801:Humans; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical; D008895:Milk, Human / Q000821:virology*; D008969:Molecular Sequence Data; D010446:Peptide Fragments / Q000235:genetics; D010802:Phylogeny; D011446:Prospective Studies; D012367:RNA, Viral / Q000235:genetics*; D012432:Rwanda; D017422:Sequence Analysis, DNA; D014764:Viral Proteins; D054301:gag Gene Products, Human Immunodeficiency Virus
chemical_list: D015683:Gene Products, gag; D015488:HIV Antigens; D015699:HIV Envelope Protein gp120; C059762:HIV envelope protein gp120 (305-321); D010446:Peptide Fragments; D012367:RNA, Viral; D014764:Viral Proteins; D054301:gag Gene Products, Human Immunodeficiency Virus; C054858:p17 protein, Human Immunodeficiency Virus Type 1