New botrydial sesquiterpenoids from Hymenoscyphus epiphyllus.
Four new botrydial derivatives, hymendial (1), 7 alpha-hydroxydihydrobotrydial (2), 7 alpha-hydroxy-10-O-methyldihydrobotrydial (4), and 7 alpha-acetoxy-15 alpha-methoxy-10-O-methyl-dihydrobotrydial (5) were isolated together with dihydrobotrydial (3) from the culture fluid of the ascomycete Hymenoscyphus epiphyllus. In addition, cytochalasin H (6a), 18-deoxycytochalasin H (6b) and (+)-mellein (7) were produced by this fungus. Hymendial (1), possessing an alpha, beta-unsaturated dialdehyde functionality, exhibits antimicrobial and cytotoxic activities and is mutagenic in the Ames Salmonella assay.
Thines
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Lehrbereich Biotechnologie der Universität Kaiserslautern, Germany.
Anke
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Steglich
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Sterner
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D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D001203:Ascomycota / Q000737:chemistry* / Q000254:growth & development; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects*; D005285:Fermentation; D006367:HeLa Cells; D006801:Humans; D007939:Leukemia L1210; D051379:Mice; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D012486:Salmonella typhimurium / Q000187:drug effects; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D012717:Sesquiterpenes