Cyanamide-induced granulocytopenia.
We report a 64-year-old male with granulocytopenia and dermatitis due to cyanamide treatment. We administered cyanamide for alcoholism. After about one month he suffered from scaly erythema over his whole body and granulocytopenia (granulocyte; 140/microliter) with maturation arrest in bone marrow. After cessation of cyanamide and the start of granulocyte colony-stimulating factor administration, the skin eruption ameliorated gradually, and the peripheral blood granulocyte counts increased. Cyanamide showed positive results in the drug lymphocyte stimulation test (198%) and the patch test led to the diagnosis of granulocytopenia and dermatitis induced by cyanamide. After restarting glibenclamide and diazepam administration, his granulocytopenia did not reoccur. To our knowledge, this is the first report of a case with granulocytopenia induced by cyanamide.
Ajima
M
M
Division of Endocrinology and Metabolism, Kanto-Teishin Hospital, Tokyo.
Usuki
K
K
Igarashi
A
A
Okazaki
R
R
Hamano
K
K
Urabe
A
A
Totsuka
Y
Y
D000380:Agranulocytosis / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy; D000437:Alcoholism / Q000188:drug therapy; D000932:Antiemetics / Q000627:therapeutic use; D003484:Cyanamide / Q000009:adverse effects*; D003872:Dermatitis / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D003975:Diazepam / Q000627:therapeutic use; D005905:Glyburide / Q000627:therapeutic use; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010328:Patch Tests
D000932:Antiemetics; D007004:Hypoglycemic Agents; D016179:Granulocyte Colony-Stimulating Factor; D003484:Cyanamide; D003975:Diazepam; D005905:Glyburide