[Effect of the nerve growth factor on blood coagulation and fibrinolysis].
It was established in rabbit experiments that intravenous infusion of 150 BU/kg of the mouse nerve growth factor causes long-term hypocoagulation and simultaneous stimulation of fibrinolysis and anticoagulant activity. The essential role of the nerve growth factor in inducing the release of heparin and histamine into the blood and its contribution to the activation of other components of fibrinolysis and the antithrombine system is shown. This may be very important for the prevention of prethrombotic conditions in the future.
Isanbaev
Ch I
ChI
Vypova
N L
NL
Kazantseva
D S
DS
Sagdiev
N
N
D000818:Animals; D000990:Antithrombin III / Q000378:metabolism; D001777:Blood Coagulation / Q000187:drug effects*; D005342:Fibrinolysis / Q000187:drug effects*; D006493:Heparin / Q000378:metabolism; D006636:Histamine Release / Q000187:drug effects; D007262:Infusions, Intravenous; D008297:Male; D051379:Mice; D009414:Nerve Growth Factors / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D010314:Partial Thromboplastin Time; D010447:Peptide Hydrolases / Q000378:metabolism; D011516:Prothrombin / Q000378:metabolism; D011817:Rabbits; D012701:Serotonin / Q000097:blood; D013918:Thrombin Time
D009414:Nerve Growth Factors; C046193:antithrombin III-protease complex; D012701:Serotonin; D000990:Antithrombin III; D011516:Prothrombin; D006493:Heparin; D010447:Peptide Hydrolases