Case report of multiple myeloma and hypothyroidism in primary biliary cirrhosis.
A 71-year-old female with primary biliary cirrhosis, multiple myeloma and hypothyroidism is reported. The liver biopsy showed stage II-III histologic damage according to Scheuer's classification and the multiple myeloma was IgG-lambda type, stage II-A at the time of diagnosis. Another three cases of primary biliary cirrhosis associated with multiple myeloma were found in the literature. As a group, the four cases had mild or moderate liver damage, extensive bone lesions and three of four cases had multiple myeloma IgG-lambda type. Although this association could be incidental, there is evidence that implies a pathogenic relationship. This information is summarized in this report.
Rodríguez-Leal
G A
GA
Gastroenterology Department, Instituto Nacional de la Nutrición Salvador Zubirán, Mexico City.
Moran-Villota
S
S
Arista-Nasr
J
J
Uribe-Esquivel
M
M
D000368:Aged; D002471:Cell Transformation, Neoplastic; D005260:Female; D006801:Humans; D006942:Hypergammaglobulinemia / Q000209:etiology; D007037:Hypothyroidism / Q000150:complications*; D007075:Immunoglobulin M / Q000097:blood; D007146:Immunoglobulin lambda-Chains / Q000032:analysis; D008105:Liver Cirrhosis, Biliary / Q000150:complications* / Q000276:immunology; D008213:Lymphocyte Activation; D016131:Lymphocyte Subsets / Q000276:immunology / Q000473:pathology; D009101:Multiple Myeloma / Q000150:complications*; D009194:Myeloma Proteins / Q000032:analysis; D014820:Vitiligo / Q000150:complications
D007075:Immunoglobulin M; D007146:Immunoglobulin lambda-Chains; D009194:Myeloma Proteins