The peroxisome proliferator-activated receptor alpha (PPAR alpha) regulates the plasma thiobarbituric acid-reactive substance (TBARS) level.
We investigated whether liver expression of the peroxisome proliferator-activated receptor alpha (PPAR alpha) gene is related to the plasma thiobarbituric acid-reactive substance (TBARS) level, as well as to plasma cholesterol (TC) level and plasma triglyceride (TG) level in rats fed a high fat chow containing a variety of fatty acids. Only the plasma TBARS level showed a significant negative correlation with the liver PPAR alpha mRNA level (TC, R = 0.001, p = 0.9967; TG, R = 0.248, p = 0.1276; TBARS, R = 0.439, p = 0.0046). Although further studies are needed to clarify whether the increase of the liver PPAR alpha mRNA level confers a reduction in plasma TBARS levels, it is likely that PPAR alpha activity plays a regulatory role in the pathogenesis of hyperlipidemia and atherosclerosis.
Inoue
I
I
Fourth Department of Medicine, Saitama Medical School, Japan.
Noji
S
S
Shen
M Z
MZ
Takahashi
K
K
Katayama
S
S
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002784:Cholesterol / Q000097:blood; D017931:DNA Primers; D004041:Dietary Fats; D005227:Fatty Acids / Q000032:analysis; D008074:Lipoproteins / Q000097:blood / Q000737:chemistry; D008099:Liver / Q000378:metabolism*; D008297:Male; D016133:Polymerase Chain Reaction; D012333:RNA, Messenger / Q000096:biosynthesis; D051381:Rats; D017207:Rats, Sprague-Dawley; D018160:Receptors, Cytoplasmic and Nuclear / Q000096:biosynthesis*; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism*; D014157:Transcription Factors / Q000096:biosynthesis*; D014158:Transcription, Genetic; D014280:Triglycerides / Q000097:blood
D001786:Blood Glucose; D017931:DNA Primers; D004041:Dietary Fats; D005227:Fatty Acids; D008074:Lipoproteins; D012333:RNA, Messenger; D018160:Receptors, Cytoplasmic and Nuclear; D017392:Thiobarbituric Acid Reactive Substances; D014157:Transcription Factors; D014280:Triglycerides; D002784:Cholesterol