Testosterone-regulated expression of enzymes involved in steroid and aromatic hydrocarbon catabolism in Comamonas testosteroni.
The effect of testosterone as the sole carbon source on protein expression was analyzed in Comamonas testosteroni. Testosterone simultaneously induced the expression of steroid- and aromatic hydrocarbon-catabolizing enzymes and repressed one amino acid-degrading enzyme. It is suggested that steroids play a regulative role in catabolic enzyme synthesis during adaptive growth of C. testosteroni.
Möbus
E
E
Department of Pharmacology and Toxicology, Philipps University, Marburg, Germany.
Jahn
M
M
Schmid
R
R
Jahn
D
D
Maser
E
E
D000595:Amino Acid Sequence; D001426:Bacterial Proteins / Q000235:genetics*; D001555:Benzene Derivatives / Q000378:metabolism; D015536:Down-Regulation; D015180:Electrophoresis, Gel, Two-Dimensional; D015964:Gene Expression Regulation, Bacterial / Q000235:genetics*; D015971:Gene Expression Regulation, Enzymologic / Q000235:genetics*; D006088:Gram-Negative Aerobic Bacteria / Q000201:enzymology / Q000235:genetics*; D008969:Molecular Sequence Data; D017386:Sequence Homology, Amino Acid; D013256:Steroids / Q000378:metabolism; D013739:Testosterone / Q000494:pharmacology*; D015854:Up-Regulation
D001426:Bacterial Proteins; D001555:Benzene Derivatives; D013256:Steroids; D013739:Testosterone