title: Chiasmal glioma in neurofibromatosis type 1 with severe visual loss regained with radiation.
abstract: Children with neurofibromatosis type 1 (NFI) and chiasmal gliomas are often considered unlikely to experience progressive visual loss. However, this may not be true. We report a 5-year, 6-month-old boy, with recently diagnosed NF1, who had a chiasmal glioma diagnosed after neuroimaging. He subsequently experienced rapid visual acuity loss. His vision improved significantly after irradiation. The controversy surrounding radiotherapy for chiasmal glioma is discussed.
authors.affiliation: Department of Pediatric Neurology, Alberta Childrens Hospital, University of Calgary, Canada.
authors.forename: C
authors.initials: C
authors.lastname: Adams
authors.forename: W A
authors.initials: WA
authors.lastname: Fletcher
authors.forename: S T
authors.initials: ST
authors.lastname: Myles
mesh_terms: D002675:Child, Preschool; D016371:Cranial Irradiation; D003390:Cranial Nerve Neoplasms / Q000175:diagnosis* / Q000532:radiotherapy; D005500:Follow-Up Studies; D005910:Glioma / Q000175:diagnosis* / Q000532:radiotherapy; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009456:Neurofibromatosis 1 / Q000175:diagnosis* / Q000532:radiotherapy; D009897:Optic Chiasm / Q000473:pathology; D014057:Tomography, X-Ray Computed; D014792:Visual Acuity / Q000528:radiation effects