title: Atrial natriuretic peptide prevents bronchoconstriction in vitro.
abstract: Under in vitro conditions atrial natriuretic peptide (ANP) caused specific relation of bronchoconstriction induced by tosyl arginine methyl ester (TAME) on rat trachea. This supports the hypothesis that ANP is a relaxant of airway as well as vascular smooth muscle and since lung tissue contains ANP and ANP receptors, it is hypothesized that the lungs may be a target organ for ANP. It is concluded that ANP had definite bronchodilating properties on rat trachea mounted in vitro and could be a possible antagonist of TAME.
authors.affiliation: Health and Medical Sciences Department, Faculty of Science, University of Mauritius, Reduit.
authors.forename: A H
authors.initials: AH
authors.lastname: Subratty
mesh_terms: D000818:Animals; D009320:Atrial Natriuretic Factor / Q000494:pharmacology*; D016084:Bronchoconstriction / Q000187:drug effects*; D066298:In Vitro Techniques; D051381:Rats; D017207:Rats, Sprague-Dawley; D014106:Tosylarginine Methyl Ester / Q000494:pharmacology
chemical_list: D009320:Atrial Natriuretic Factor; D014106:Tosylarginine Methyl Ester