IL-6 and APPs: anti-inflammatory and immunosuppressive mediators.
Acute inflammation is accompanied by changes in the concentrations of acute phase proteins (APPs). While much is known about the cytokines involved in the initiation of inflammation, less is known about the mediators involved in its resolution. Recent data suggest that interleukin 6 (IL-6) and IL-6-regulated APPs are anti-inflammatory and immuno-suppressive, and may negatively regulate the acute phase response.
Tilg
H
H
Dept of Medicine, University Hospital Innsbruck, Austria. Internal-Medicine@uibk.ac.at
Dinarello
C A
CA
Mier
J W
JW
D000209:Acute-Phase Proteins / Q000276:immunology*; D000486:Allergy and Immunology / Q000639:trends; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000276:immunology; D002490:Central Nervous System / Q000276:immunology; D016207:Cytokines / Q000096:biosynthesis; D006801:Humans; D007108:Immune Tolerance; D066298:In Vitro Techniques; D015850:Interleukin-6 / Q000235:genetics / Q000276:immunology* / Q000494:pharmacology; D051379:Mice; D018345:Mice, Knockout; D008954:Models, Biological
D000209:Acute-Phase Proteins; D000893:Anti-Inflammatory Agents; D016207:Cytokines; D015850:Interleukin-6