title: Scaling lichenoid eruptions and Sjögren-like syndrome: manifestations of nonfatal postoperative transfusion-associated graft-versus-host disease?
abstract: We report a case of an 81-year-old woman in whom lichenoid eruptions and Sjögren-like sicca syndrome developed 45 days after cholecystectomy. During surgery, one unit (130 ml) of unirradiated packed red blood cells from a male donor was transfused. The lichenoid eruptions cleared up with exfoliation: however, sicca symptoms remained during the follow-up period of four years. Histological examinations of both skin and lip biopsy specimens were in agreement with those of graft-versus-host disease (GVHD). A Y-chromosomal body was identified in the lymphocytes in the skin lesion by staining with quinacrine dihydrochloride and in the lip lesion by a method with in situ hybridization. The findings suggest that this case demonstrated the manifestations of non-fatal transfusion-associated GVHD.
authors.affiliation: Department of Dermatology, Tokyo Metropolitan Geriatric Hospital, Japan.
authors.forename: R
authors.initials: R
authors.lastname: Tanei
authors.forename: T
authors.initials: T
authors.lastname: Yamamoto
authors.forename: H
authors.initials: H
authors.lastname: Yokono
authors.forename: T
authors.initials: T
authors.lastname: Motoori
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001707:Biopsy, Needle; D002763:Cholecystectomy; D003937:Diagnosis, Differential; D005260:Female; D006086:Graft vs Host Disease / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology; D006680:HLA Antigens / Q000032:analysis; D006801:Humans; D017512:Lichenoid Eruptions / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology; D008297:Male; D012859:Sjogren's Syndrome / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology; D065227:Transfusion Reaction
chemical_list: D006680:HLA Antigens