Microtubule-associated proteins (MAPs) in the peripheral nervous system during development and regeneration.
In this article, we have described the structure and distribution of the various variants of the microtubule-associated proteins (MAPs), tau, MAP2, MAP1A, and MAP1B, that are expressed in the dorsal root ganglion (DRG) and spinal cord during development and regeneration. We have summarized the data on their gene structure and compared the sequence of the major transcripts encoding these MAPs that are expressed in the brain, the spinal cord, and the DRG. Finally, we have surveyed the studies that used a variety of experimental approaches (e.g., antisense inhibition, transgenic knockouts, and expression in neuronal and nonneuronal cells) to understand the functional significance of MAPs heterogeneity and differences observed between the central nervous system (CNS) and the peripheral nervous system (PNS) both during development and regeneration.
Nunez
J
J
Department of Neurobiology and Anatomy, Allegheny University, Philadelphia, PA 19129, USA.
Fischer
I
I
D017398:Alternative Splicing; D000818:Animals; D001369:Axons / Q000502:physiology; D001921:Brain / Q000254:growth & development / Q000502:physiology; D005727:Ganglia, Spinal / Q000254:growth & development / Q000502:physiology; D006801:Humans; D008869:Microtubule-Associated Proteins / Q000096:biosynthesis* / Q000235:genetics; D009416:Nerve Regeneration; D017933:Peripheral Nervous System / Q000254:growth & development* / Q000502:physiology; D013116:Spinal Cord / Q000254:growth & development / Q000502:physiology; D014158:Transcription, Genetic
D008869:Microtubule-Associated Proteins