IL-6: insights into novel biological activities.
IL-6 has many novel activities both within the adaptive immune system and without. It has therapeutic potential in acute inflammation, such as toxic or septic shock, and it is a potential target for cachexia, multiple myeloma, and osteoporosis. Further work on these aspects of IL-6 biology should yield new insight into the possibility of IL-6 both as a therapeutic agent and as a target for antagonists.
Barton
B E
BE
Department of Surgery, UMDNJ-NJMS, Newark 07103, USA. bartonbe@umdnj.edu
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D001862:Bone Resorption / Q000209:etiology / Q000276:immunology; D002100:Cachexia / Q000209:etiology / Q000276:immunology; D016207:Cytokines / Q000235:genetics / Q000494:pharmacology / Q000502:physiology; D006801:Humans; D015850:Interleukin-6 / Q000235:genetics / Q000494:pharmacology / Q000502:physiology*; D009500:Neutralization Tests; D010010:Osteoclasts / Q000502:physiology
D000893:Anti-Inflammatory Agents; D016207:Cytokines; D015850:Interleukin-6