Borrelidin is an angiogenesis inhibitor; disruption of angiogenic capillary vessels in a rat aorta matrix culture model.
Borrelidin, an antibiotic from Streptomyces rochei, was found to be an angiogenesis inhibitor in a rat aorta matrix culture model which forms capillary vessels in vitro. Borrelidin strongly inhibited capillary tube formation with a 50%-inhibitory concentration value of 0.8 nM, and decreased the number of capillary tubes within 24 hours when added after maturation of tube formation. Borrelidin remarkably disrupted capillary tubes in a dose-dependent manner, by inducing apoptosis of the tube-forming cells.
Wakabayashi
T
T
Tsukuba Research Laboratories, Eisai, Co., Ltd., Ibaraki, Japan.
Kageyama
R
R
Naruse
N
N
Tsukahara
N
N
Funahashi
Y
Y
Kitoh
K
K
Watanabe
Y
Y
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001011:Aorta / Q000187:drug effects / Q000648:ultrastructure; D017209:Apoptosis / Q000187:drug effects; D002196:Capillaries / Q000187:drug effects / Q000254:growth & development; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D005233:Fatty Alcohols / Q000494:pharmacology; D006801:Humans; D008297:Male; D051379:Mice; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D009389:Neovascularization, Pathologic / Q000517:prevention & control*; D051381:Rats; D017207:Rats, Sprague-Dawley
D000900:Anti-Bacterial Agents; D005233:Fatty Alcohols; C005066:borrelidin