Update on antifungal resistance.
Overuse of antifungal agents has resulted in the selection of naturally resistant Candida species, as well as expression of resistance from previously susceptible species resulting from genetic mutations and/or selection of resistant subpopulations. Strategies for the appropriate use of antifungal agents need to be developed to prevent further development of resistance.
Klepser
M E
ME
University of Iowa College of Pharmacy, Iowa City 52242, USA. michael-klepser@uiowa.edu
Ernst
E J
EJ
Pfaller
M A
MA
D000935:Antifungal Agents / Q000627:therapeutic use*; D002175:Candida / Q000235:genetics / Q000472:pathogenicity; D002177:Candidiasis / Q000188:drug therapy*; D004352:Drug Resistance, Microbial; D004358:Drug Therapy / Q000379:methods; D005658:Fungi / Q000235:genetics / Q000472:pathogenicity; D006801:Humans; D009154:Mutation; D009181:Mycoses / Q000188:drug therapy*
D000935:Antifungal Agents