Evidence that certain 8-aminoquinolines are potentially effective drugs against Chagas disease.
Forty 8-aminoquinolines (a chemical class with members having some activity against Trypanosoma cruzi infections) were evaluated for their effectiveness in reducing the 14-day parasitaemias of 4-6 week-old, female, albino mice infected with a Brazilian strain of T. cruzi. Six of the compounds were more active or as active as the reference drug, nifurtimox, and one was > 13-fold as efficacious. Certain members of the series tested warrant further evaluation.
Kinnamon
K E
KE
Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Washington, DC 20307-5100, USA. kinnamon@usuhsb.usuhs.mil
Poon
B T
BT
Hanson
W L
WL
Waits
V B
VB
D000634:Aminoquinolines / Q000627:therapeutic use*; D000818:Animals; D000977:Antiparasitic Agents / Q000627:therapeutic use; D014355:Chagas Disease / Q000188:drug therapy*; D004353:Drug Evaluation, Preclinical; D005260:Female; D051379:Mice; D009547:Nifurtimox / Q000627:therapeutic use; D018512:Parasitemia / Q000188:drug therapy*
D000634:Aminoquinolines; D000977:Antiparasitic Agents; D009547:Nifurtimox