Antipsoriatic anthrones: aspects of oxygen radical formation, challenges and prospects.
1. Antipsoriatic anthrones are among the most commonly used topical agents for the treatment of psoriasis. 2. These drugs generate reactive oxygen species during their auto-oxidation under physiological conditions. 3. Recent studies have indicated that activation of molecular oxygen by anthrones may play a critical role in their mechanism of action at the molecular level. 4. This article summarizes the evidence pointing toward the significance of oxygen activation and radical formation in the antipsoriatic action and induction of skin inflammation of anthrones. 5. Also, the role of oxygen radical formation in the development of novel anthrones devoid of inflammatory and staining properties is discussed.
Müller
K
K
Institute of Pharmacy, University of Regensburg, Germany.
D000287:Administration, Topical; D000875:Anthralin / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology; D000893:Anti-Inflammatory Agents / Q000378:metabolism* / Q000494:pharmacology; D004249:DNA Damage; D003872:Dermatitis / Q000503:physiopathology; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005609:Free Radicals; D006801:Humans; D066298:In Vitro Techniques; D015227:Lipid Peroxidation; D010101:Oxygen Consumption; D011565:Psoriasis / Q000188:drug therapy* / Q000378:metabolism; D017382:Reactive Oxygen Species
D000893:Anti-Inflammatory Agents; D004791:Enzyme Inhibitors; D005609:Free Radicals; D017382:Reactive Oxygen Species; D000875:Anthralin