Characterization of prostaglandin H synthase 2 deficient mice and implications for mechanisms of NSAID action.
Morham
S G
SG
Department of Pathology, University of North Carolina at Chapel Hill 27599-7525, USA.
Langenbach
R
R
Mahler
J
J
Smithies
O
O
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology* / Q000633:toxicity; D001284:Atrophy; D051545:Cyclooxygenase 1; D051546:Cyclooxygenase 2; D052246:Cyclooxygenase 2 Inhibitors; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology* / Q000633:toxicity; D005355:Fibrosis; D018390:Gene Targeting; D006984:Hypertrophy; D007249:Inflammation / Q000201:enzymology; D007527:Isoenzymes / Q000172:deficiency* / Q000235:genetics / Q000502:physiology; D007668:Kidney / Q000201:enzymology / Q000473:pathology*; D007672:Kidney Cortex / Q000201:enzymology / Q000473:pathology; D007678:Kidney Glomerulus / Q000201:enzymology / Q000473:pathology; D008565:Membrane Proteins; D051379:Mice; D018345:Mice, Knockout; D010538:Peritonitis / Q000201:enzymology / Q000235:genetics*; D011451:Prostaglandin-Endoperoxide Synthases / Q000172:deficiency* / Q000235:genetics / Q000502:physiology; D011453:Prostaglandins / Q000502:physiology; D013276:Stomach Ulcer / Q000139:chemically induced
D000894:Anti-Inflammatory Agents, Non-Steroidal; D052246:Cyclooxygenase 2 Inhibitors; D016861:Cyclooxygenase Inhibitors; D007527:Isoenzymes; D008565:Membrane Proteins; D011453:Prostaglandins; D051545:Cyclooxygenase 1; D051546:Cyclooxygenase 2; D011451:Prostaglandin-Endoperoxide Synthases; C496512:Ptgs1 protein, mouse