Four new clerodane diterpenes from the leaves of Casearia guianensis which inhibit the interaction of leukocyte function antigen 1 with intercellular adhesion molecule 1.
Four new clerodane diterpenes, casearinols A and B (1 and 2) and casearinones A and B (3 and 4), were isolated from the leaves of Casearia guianensis. These immunomodulatory compounds have been structurally elucidated primarily on the basis of 2D NMR analysis and spectral data comparison with known compounds. These compounds inhibited the binding of T-cell leukocyte function antigen 1 to intercellular adhesion molecule 1.
Hunter
M S
MS
Searle Research and Development, Monsanto Company, St. Louis, Missouri 63198, USA.
Corley
D G
DG
Carron
C P
CP
Rowold
E
E
Kilpatrick
B F
BF
Durley
R C
RC
D000276:Adjuvants, Immunologic / Q000302:isolation & purification* / Q000494:pharmacology; D002240:Carbohydrate Sequence; D002851:Chromatography, High Pressure Liquid; D004224:Diterpenes / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000378:metabolism*; D039841:Leukocyte L1 Antigen Complex; D009682:Magnetic Resonance Spectroscopy; D008969:Molecular Sequence Data; D019006:Neural Cell Adhesion Molecules / Q000378:metabolism*; D018515:Plant Leaves / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry; D011485:Protein Binding; D013056:Spectrophotometry, Ultraviolet
D000276:Adjuvants, Immunologic; D004224:Diterpenes; D039841:Leukocyte L1 Antigen Complex; D019006:Neural Cell Adhesion Molecules; D018799:Intercellular Adhesion Molecule-1