Involvement of TNF-alpha secreting macrophages in lethal forms of human graft-versus-host disease.
We report three patients with lethal forms of acute GVHD in whom all biopsy specimens showed a striking preponderance of macrophages in the inflammatory infiltrate with production of TNF-alpha. The role of the macrophage/TNF-alpha axis in human acute GVHD is examined and the existence of primary macrophagic forms of GVHD is discussed.
Facon
T
T
Unité Régionale de Greffe de Moelle Osseuse, CHRU Lille, France.
Jouet
J P
JP
Noel-Walter
M P
MP
Bloget
F
F
Bauters
F
F
Janin
A
A
D000328:Adult; D016026:Bone Marrow Transplantation; D002648:Child; D017809:Fatal Outcome; D005260:Female; D006086:Graft vs Host Disease / Q000276:immunology / Q000473:pathology*; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000276:immunology / Q000473:pathology / Q000628:therapy; D015470:Leukemia, Myeloid, Acute / Q000276:immunology / Q000473:pathology / Q000628:therapy; D008264:Macrophages / Q000378:metabolism* / Q000502:physiology; D008875:Middle Aged; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism* / Q000502:physiology
D014409:Tumor Necrosis Factor-alpha