title: Identification of new medium-chain acylcarnitines present in normal human urine.
abstract: Analysis of urinary medium-chain acylcarnitines extracted on C18 cartridges and gas chromatography mass spectrometry of their fatty acid moieties as picolinyl esters allowed the determination of the chemical structure of previously unidentified acylcarnitines in normal human urine. These are the 2,6-dimethylheptanoyl-, the 2,6-dimethyl-5-heptenoyl-, and the trans- and cis-3,4-methylene heptanoylcarnitines, also named 3-cyclopropane octanoylcarnitines. Assessment of the structure of these cyclopropane derivatives was obtained by 1H and 13C nuclear magnetic resonance spectroscopy. In addition, other acylcarnitines were tentatively identified.
authors.affiliation: Département de Biologie Clinique, Cliniques Universitaires St. Luc, 10 Avenue Hippocrate, Brussels, B-1200, Belgium.
authors.forename: R
authors.initials: R
authors.lastname: Libert
authors.forename: F
authors.initials: F
authors.lastname: Van Hoof
authors.forename: M
authors.initials: M
authors.lastname: Thillaye
authors.forename: M F
authors.initials: MF
authors.lastname: Vincent
authors.forename: M C
authors.initials: MC
authors.lastname: Nassogne
authors.forename: V
authors.initials: V
authors.lastname: Stroobant
authors.forename: E
authors.initials: E
authors.lastname: de Hoffmann
authors.forename: A
authors.initials: A
authors.lastname: Schanck
mesh_terms: D000215:Acylation; D002331:Carnitine / Q000031:analogs & derivatives / Q000652:urine*; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods*; D006801:Humans; D012016:Reference Values; D016339:Spectrometry, Mass, Fast Atom Bombardment
chemical_list: D002331:Carnitine