In vitro study of the antiseborrheic activity of zinc L-cysteate, a novel zinc compound, on rat preputial gland.
The antiseborrheic effect of zinc L-cysteate, a new zinc compound, was evaluated in vitro by determining the lipidic metabolic activity of rat preputial glands as measured by incorporation of 14C-sodium acetate. At 10(-3) and 10(-4) mol/l, zinc L-cysteate was more active than S-carboxymethyl L-cysteine used as reference in corresponding concentrations (p < 0.05 and p < 0.01, respectively). The pharmacologic results seem promising for clinical studies in dermatology.
Guillard
O
O
Department of Biochemistry and Toxicology (EA 1223), Jean Bernard Hospital, Poitiers, France.
Fauconneau
B
B
Piriou
A
A
Pineau
A
A
D000818:Animals; D000891:Anti-Infective Agents, Local / Q000494:pharmacology*; D002233:Carbocysteine / Q000494:pharmacology; D003544:Cysteic Acid / Q000031:analogs & derivatives / Q000494:pharmacology* / Q000627:therapeutic use; D012628:Dermatitis, Seborrheic / Q000188:drug therapy; D066298:In Vitro Techniques; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012867:Skin / Q000187:drug effects* / Q000378:metabolism; D019346:Sodium Acetate / Q000378:metabolism; D015032:Zinc / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use
D000891:Anti-Infective Agents, Local; D019346:Sodium Acetate; D002233:Carbocysteine; D003544:Cysteic Acid; D015032:Zinc