title: [A polyvalent complex of Bordetella pertussis antigens as the basis for an acellular pertussis vaccine].
abstract: The immunogenic and protective properties of acellular pertussis vaccines, prepared on the basis of B. pertussis multicomponent protective complex and the preparation containing only pertussis toxin, were studied. The study revealed that multicomponent preparations containing pertussis toxin (PT), filamentous hemagglutinin, agglutinogens, pertactin and adenylate cyclase possessed more pronounced immunobiological and protective properties in comparison with the monovalent preparation of PT, which was indicative of the expediency of developing acellular pertussis vaccines on the basis of the polyvalent protective complex as minor protective antigens seemed to enhance the protective action of pertussis toxoid, the main protective antigen.
authors.forename: N S
authors.initials: NS
authors.lastname: Zakharova
authors.forename: E I
authors.initials: EI
authors.lastname: Shmeleva
authors.forename: T N
authors.initials: TN
authors.lastname: Remova
authors.forename: I G
authors.initials: IG
authors.lastname: Bazhanova
authors.forename: M N
authors.initials: MN
authors.lastname: Ozeretskovskaia
authors.forename: N U
authors.initials: NU
authors.lastname: Mertsalova
authors.forename: M V
authors.initials: MV
authors.lastname: Britsina
authors.forename: E V
authors.initials: EV
authors.lastname: Ermolova
authors.forename: E M
authors.initials: EM
authors.lastname: Zaĭtsev
mesh_terms: D037361:Adenylate Cyclase Toxin; D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood; D000942:Antigens, Bacterial / Q000276:immunology* / Q000302:isolation & purification; D001886:Bordetella pertussis / Q000276:immunology*; D015721:Diphtheria-Tetanus-Pertussis Vaccine / Q000276:immunology / Q000302:isolation & purification; D007114:Immunization; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D037342:Pertussis Toxin; D010567:Pertussis Vaccine / Q000276:immunology* / Q000302:isolation & purification; D011817:Rabbits; D010566:Virulence Factors, Bordetella / Q000276:immunology / Q000302:isolation & purification
chemical_list: D037361:Adenylate Cyclase Toxin; D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D015721:Diphtheria-Tetanus-Pertussis Vaccine; D010567:Pertussis Vaccine; D010566:Virulence Factors, Bordetella; D037342:Pertussis Toxin