title: Distributions of fibroblast growth factor and the mRNA for its receptor, MFR1, in the developing testis of the medaka, Oryzias latipes.
abstract: The distribution of fibroblast growth factor (FGF) and of the mRNA for its receptor encoded by MFR1 were examined in the testis of the medaka, Oryzias latipes. FGF was detected in the region of somatic cells, especially in Sertoli cells in the matured testis by immunostaining. The staining was also detected in some of the type A spermatogonia. The distribution of FGF in the testis of the fry, in which spermatogenesis had not been initiated, was different from that in the adult. Signals of mRNA were observed in the same region as FGF in the matured testis. Staining was also detected in the testis of the fry in which spermatogenesis had been initiated. Therefore, the role of FGF in the testis of the fry in the early developmental stages may be different from that of the adult: These results indicate that FGF regulates the activation of somatic cells in the testis through the MFR1 receptor, and that it might play a significant role in the initiation and the progression of spermatogenesis in the testis of O. latipes.
authors.affiliation: Department of Biology, Faculty of Science, Yamagata University, Japan. watan@sci.kj.yamagata-u.ac.jp
authors.forename: A
authors.initials: A
authors.lastname: Watanabe
authors.forename: N
authors.initials: N
authors.lastname: Hatakeyama
authors.forename: A
authors.initials: A
authors.lastname: Yasuoka
authors.forename: K
authors.initials: K
authors.lastname: Onitake
mesh_terms: D000818:Animals; D005346:Fibroblast Growth Factors / Q000378:metabolism*; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D008297:Male; D009990:Oryzias / Q000502:physiology*; D012333:RNA, Messenger / Q000378:metabolism*; D020794:Receptor Protein-Tyrosine Kinases; D051496:Receptor, Fibroblast Growth Factor, Type 1; D017468:Receptors, Fibroblast Growth Factor / Q000235:genetics / Q000378:metabolism*; D013091:Spermatogenesis / Q000502:physiology; D013737:Testis / Q000254:growth & development / Q000378:metabolism*
chemical_list: D012333:RNA, Messenger; D017468:Receptors, Fibroblast Growth Factor; D005346:Fibroblast Growth Factors; D020794:Receptor Protein-Tyrosine Kinases; D051496:Receptor, Fibroblast Growth Factor, Type 1