Plasma fibronectin: predictive factor in gestational hypertension?
Our purpose was to evaluate fibronectin as a marker of endothelial cell injury, and as a test for predicting preeclampsia. A retrospective study was performed from November 1993 to March 1995. Results from 142 women were examined: 108 normal pregnant women and 34 pregnant women with evidence of preeclampsia. The plasma fibronectin concentration was significantly higher in pre-eclamptic gravidas (620 +/- 210 mg/l) than in normotensive gravidae women (390 +/- 130 mg/l). A fibronectin concentration lower than 400 mg/l predicted the non-development of a hypertension with a negative predictive value of 96%. The present findings suggest that fibronectin is rather an exclusion parameter than predictive test for hypertension disorders of pregnancy.
Arnaud
C
C
Laboratoire de Biochimie, Hôpital Nord, Marseille, France.
Chau
C
C
Dizier
B
B
Gamerre
M
M
Rochat
H
H
D000328:Adult; D005260:Female; D005353:Fibronectins / Q000097:blood*; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000150:complications; D011225:Pre-Eclampsia / Q000097:blood; D011237:Predictive Value of Tests; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000097:blood*; D011507:Proteinuria; D012189:Retrospective Studies; D014527:Uric Acid / Q000097:blood
D005353:Fibronectins; D014527:Uric Acid