The Charlotte Friend Memorial Lecture. The role of hematopoietic growth factors in the development and suppression of myeloid leukemias.
The transformation of normal hematopoietic cells to leukemic cells requires cells to acquire two intrinsic changes. These are the acquisition by some method of autocrine growth stimulation and a perturbation of differentiation commitment leading to abnormal levels of self-generation. Hematopoietic regulator action can be involved to produce or facilitate both these changes but the same regulators can also suppress some leukemic populations by enforced differentiation commitment.
Metcalf
D
D
The Walter and Eliza Hall Institute of Medical Research, PO Royal Melbourne Hospital, Victoria, Australia.
D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects / Q000502:physiology; D002455:Cell Division / Q000187:drug effects / Q000502:physiology; D002471:Cell Transformation, Neoplastic; D016298:Hematopoietic Cell Growth Factors / Q000494:pharmacology / Q000502:physiology*; D006801:Humans; D007951:Leukemia, Myeloid / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology*
D016298:Hematopoietic Cell Growth Factors