General and local scleroderma in children and dermatomyositis and associated syndromes.
Scleroderma in children virtually always manifests in the form of localized disease, whereas adult scleroderma usually manifests as systemic disease. The recent literature on childhood scleroderma is limited almost exclusively to localized disease. The treatment of this disease remains a dilemma, especially with regard to which patients should be treated, how they should be treated, and how the treatment response should be monitored. Our current therapeutic approach is reviewed. The recent literature regarding juvenile dermatomyositis is discussed. New understanding of the pathobiology of this disease should lead to improved, less toxic treatments in the future.
Laxer
R M
RM
University of Toronto, Division of Rheumatology, Hospital for Sick Children, Ontario, Canada.
Feldman
B M
BM
D002648:Child; D003882:Dermatomyositis / Q000150:complications / Q000209:etiology* / Q000628:therapy*; D006801:Humans; D012594:Scleroderma, Localized / Q000150:complications / Q000209:etiology* / Q000628:therapy*; D012595:Scleroderma, Systemic / Q000150:complications / Q000209:etiology* / Q000628:therapy*; D013577:Syndrome