Thallium-201 single photon emission computed tomography imaging of meningioma cells in hyperostosis.
Hyperostosis is a well-known bony reaction associated with meningioma. However, it is difficult to determine preoperatively whether meningioma cells have invaded the bone, and if so, the extent of tumor invasion. Preoperative thallium-201 chloride single photon emission computed tomography (201Tl SPECT) was performed in four patients with meningioma and hyperostosis. The presence of meningioma cells in bone biopsy specimens was also investigated using standard histological techniques. 201Tl SPECT revealed increased uptake in three of the four patients. Biopsy specimens from these three patients revealed invasion of the bony lesions by meningioma cells in accordance with the 201Tl SPECT findings. 201Tl SPECT found no abnormal uptake in the other patient, in which there was also no histological evidence of tumor invasion of bone. Preoperative 201Tl SPECT can provide information on bone invasion by meningioma, which will facilitate preoperative planning of the extent of bony resection required at meningioma surgery.
Mori
K
K
Department of Neurosurgery, Juntendo University Izunagaoka Hospital, Shizuoka.
Cho
K
K
Suda
K
K
Ishimaru
S
S
Maeda
M
M
D000293:Adolescent; D000328:Adult; D000368:Aged; D003399:Craniotomy; D005260:Female; D006801:Humans; D015576:Hyperostosis / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D008279:Magnetic Resonance Imaging; D008297:Male; D008577:Meningeal Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D008579:Meningioma / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D012886:Skull / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D012888:Skull Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D013793:Thallium; D013794:Thallium Radioisotopes; D015899:Tomography, Emission-Computed, Single-Photon
D013794:Thallium Radioisotopes; C027549:thallium chloride; D013793:Thallium