title: [Cerebral abscess and cyanotic congenital heart disease].
abstract: Cerebral abscess is a classical complication of cyanotic congenital heart disease. The authors report 7 cases of cerebral abscess diagnosed since 1982. One asymptomatic patient died of a postoperative cerebral haemorrage. The child was repatriated from Africa for complete correction of his cardiac lesion. The presentation of the other 6 cases was quite typical : headaches, pyrexia and vomiting with a neurological deficit in 4 cases : two hemiparesias and two homonymous lateral hemianopsia. These 6 patients recovered without sequeilae. Four underwent surgical drainage of the abscess with antibiotic therapy. Two recovered with antibiotic therapy alone. The causal organism was only identified in patients undergoing surgical drainage and then only in 3 cases. They were gram positive cocci, in particular the streptococcus. The association ampicillin-chloramphenicol has often been proposed as the treatment of first intention. Adaptation of antibiotic therapy then depends on clinical, biological, bacteriological (CSF, blood cultures, portal of entry) outcomes and the results of CT scanning. The association of a third generation cephalosporin and an imidazole may be proposed as treatment of second intention. The minimal duration of treatment is generally acknowledged to be 4 weeks for intravenous therapy in cases of medical therapy alone, and 2 to 3 weeks in cases with surgical drainage. The age of apparition of this complication seems to be increasing as the average age was 16 in this series (cerebral abscess is classically described as occurring between 8 and 12 years of age). This may be due to palliative surgery which reduces systemic hypoxia and polycythaemia. It also appears that neurological drainage is not systematic now because of early diagnosis of this complication. Finally, in the last few years, a new population of patients is becoming more common : patients repatriated by humanitary organisations in the third world, which should incite great vigilance in the preoperative period in this pathology.
authors.affiliation: Service de cardiologie pédiatrique, Hôpital cardiologique du Haut-Lévêque, université de Bordeaux II, Pessac.
authors.forename: P
authors.initials: P
authors.lastname: Guérin
authors.forename: P
authors.initials: P
authors.lastname: Dos Santos
authors.forename: M
authors.initials: M
authors.lastname: Jimenez
authors.forename: E
authors.initials: E
authors.lastname: Dumas de la Roque
authors.forename: L
authors.initials: L
authors.lastname: Labbé
authors.forename: B
authors.initials: B
authors.lastname: Solelhac
authors.forename: S
authors.initials: S
authors.lastname: Srour
authors.forename: A
authors.initials: A
authors.lastname: Choussat
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001922:Brain Abscess / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D002648:Child; D003490:Cyanosis; D006330:Heart Defects, Congenital / Q000150:complications* / Q000503:physiopathology / Q000628:therapy; D006801:Humans; D008297:Male; D013291:Streptococcus / Q000302:isolation & purification; D014055:Tomography, Emission-Computed; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents