title: Interferon-alpha associated arthritis.
abstract: We describe a patient who developed progressive inflammatory polyarthritis after treatment with interferon-alpha (IFN-alpha) for chronic hepatitis C infection. Rechallenge with the drug caused worsening of the arthritis, but withdrawal did not result in remission. Preexisting autoantibodies and HLA-DR4 were detected in this serum and are thought to be relevant in the etiology of IFN-alpha associated autoimmune disease.
authors.affiliation: Rheumatology Service, Brooke Army Medical Center, San Antonio, TX, USA.
authors.forename: A
authors.initials: A
authors.lastname: Chung
authors.forename: S A
authors.initials: SA
authors.lastname: Older
mesh_terms: D000328:Adult; D000998:Antiviral Agents / Q000009:adverse effects*; D001168:Arthritis / Q000139:chemically induced* / Q000276:immunology; D001323:Autoantibodies / Q000032:analysis; D002908:Chronic Disease; D015804:HLA-DR4 Antigen / Q000276:immunology; D006526:Hepatitis C / Q000188:drug therapy / Q000276:immunology; D006801:Humans; D016898:Interferon-alpha / Q000009:adverse effects*; D008297:Male; D011994:Recombinant Proteins
chemical_list: D000998:Antiviral Agents; D001323:Autoantibodies; D015804:HLA-DR4 Antigen; D016898:Interferon-alpha; D011994:Recombinant Proteins