Immunohistochemical investigations of genital ulcers caused by Haemophilus ducreyi.
To gain information on the specific composition of the inflammatory infiltrate of genital ulcers caused by Haemophilus ducreyi, biopsies of 6 genital ulcers which were diagnosed as chancroid on clinical and microbiological grounds were subjected to immunohistochemical investigations after conventional haematoxylineosin staining. A variety of antibodies reactive against B- and T-cells, plasma cells and granulocytes were used with each tissue sections. The lymphocytic infiltrate of chancroid ulcers consisted of both B- and T-lymphocytes and showed a cluster-like formation. B-lymphocytes were preferentially localized perivascularly in the middle layer, T-lymphocytes mainly in the deep layer of the inflamed oedematous tissue. Results stress the importance of both B- and T-cell mediated immune responses in Haemophilus ducreyi infection.
Abeck
D
D
Department of Dermatology and Allergy, Technical University, Munich, Germany.
Freinkel
A L
AL
Korting
H C
HC
Szeimis
R M
RM
Ballard
R C
RC
D000907:Antibodies, Bacterial / Q000096:biosynthesis; D000911:Antibodies, Monoclonal; D001706:Biopsy; D002602:Chancroid / Q000473:pathology*; D006191:Haemophilus ducreyi; D006801:Humans; D008297:Male; D010409:Penile Diseases / Q000382:microbiology / Q000473:pathology*; D012883:Skin Ulcer / Q000382:microbiology / Q000473:pathology*
D000907:Antibodies, Bacterial; D000911:Antibodies, Monoclonal