Biomonitoring exposure to environmental tobacco smoke (ETS): a critical reappraisal.
1 The most frequently used biomarkers for exposure to environmental tobacco smoke (ETS) are cotinine and thiocyanate in body fluids, carboxyhaemoglobin in red blood cells (COHb) and carbon monoxide in the expired air. Although not ideal, cotinine in blood, saliva or urine is an established biomarker for ETS exposure within the past 1-3 days. Comparison with cotinine concentrations in cigarette smokers reveals that passive smokers take up less than 1/100 of the nicotine dose of smokers. 2 Biomonitoring data available for the ETS-related exposure to genotoxic substances comprise uptake of benzene, polycyclic aromatic hydrocarbons (PAH), aromatic amines, tobacco-specific nifrosamines (TSNA), electrophilic compounds giving rise to urinary thioethers, mutagens causing urinary mutagenic activity and the formation of various DNA adducts. With the exception of TSNA, these biomarkers are related to chemicals occurring ubiquitously in the environment and in the food. As a consequence, the background levels in unexposed nonsmokers are high compared to the observed increases (if any) associated with ETS exposure. 3 Some markers of biological effects, which, by definition, are non-specific with regard to the underlying exposure, have also been investigated in relation to ETS exposure. These markers comprise cytogenetic effects, aryl hydrocarbon hydroxylase (AHH) induction, urinary hydroxyproline excretion and various factors indicative of cardiovascular risks. The available data suggest that passive smoking is associated with a small induction of placental AHH and also with effects on cardiovascular risk markers. The latter findings in particular may be confounded by other risk factors, which have been observed to be more frequent in passive smokers than in unexposed nonsmokers.
Scherer
G
G
Analytisch-biologisches Forschungslabor München (ABF), Germany.
Richter
E
E
D001554:Benzene / Q000493:pharmacokinetics / Q000633:toxicity; D015415:Biomarkers; D002248:Carbon Monoxide / Q000493:pharmacokinetics; D003367:Cotinine / Q000493:pharmacokinetics; D004781:Environmental Exposure / Q000009:adverse effects*; D004784:Environmental Monitoring / Q000379:methods*; D006801:Humans; D009153:Mutagens / Q000633:toxicity; D012907:Smoking / Q000009:adverse effects*; D013861:Thiocyanates / Q000493:pharmacokinetics; D014028:Tobacco Smoke Pollution / Q000009:adverse effects*
D015415:Biomarkers; D009153:Mutagens; D013861:Thiocyanates; D014028:Tobacco Smoke Pollution; D002248:Carbon Monoxide; D001554:Benzene; D003367:Cotinine; C031760:thiocyanate