Association of Myc with the zinc-finger protein Miz-1 defines a novel pathway for gene regulation by Myc.
The Myc protein activates transcription as part of a complex with its partner protein, Max. Myc-transformed cells are also characterised by the loss of expression of a number of genes and this repressive effect of Myc on gene expression may not be mediated by the Myc/Max complex. We recently isolated by two-hybrid cloning a novel zinc-finger protein that associates with the carboxy-terminus of Myc. We have termed this protein Miz-1 (Myc-interacting zinc finger protein). Some of the properties of Miz-1 suggest that it may be involved in gene repression by Myc in vivo.
Schneider
A
A
Zentrum für Molekulare Biologie Heidelberg (ZMBH), Germany.
Peukert
K
K
Eilers
M
M
Hänel
F
F
D000818:Animals; D002455:Cell Division; D002471:Cell Transformation, Neoplastic; D004268:DNA-Binding Proteins / Q000378:metabolism*; D005786:Gene Expression Regulation; D006367:HeLa Cells; D006801:Humans; D051741:Kruppel-Like Transcription Factors; D008954:Models, Biological; D016271:Proto-Oncogene Proteins c-myc / Q000378:metabolism*; D014157:Transcription Factors / Q000378:metabolism*; D016335:Zinc Fingers
D004268:DNA-Binding Proteins; D051741:Kruppel-Like Transcription Factors; D016271:Proto-Oncogene Proteins c-myc; D014157:Transcription Factors; C107961:ZBTB17 protein, human