title: Normal neurocognitive performance after extended practice in patients with schizophrenia.
abstract: This study evaluated new methods for improving the performance of patients with schizophrenia on specific neurocognitive tasks. Patients (n = 22) practiced sustained perceptual, memory and motor tasks 5 times/week for 10 weeks. Tasks were initially easy enough for patients to do well, but were made gradually more difficult over the 10 weeks. Patients received base pay and performance-based monetary supplements. No coaching or ongoing instruction was provided, and performance gains were assumed to depend upon implicit learning. High functioning healthy controls (n = 5) were given the same tasks at difficulty levels comparable to those achieved by patients after 10 weeks of practice. After 10 weeks of practice, 16 of the 22 patients performed as well or better than the best control on the perceptual and memory tasks, and 11 patients performed within the range of control subjects on the motor task. Half of the patients retested 6 months after training maintained supranormal performance, while the others showed marked performance declines. Patients with schizophrenia appear to have greater potential for neurocognitive improvement, and potentially for employment, than generally appreciated.
authors.affiliation: Yale Department of Psychiatry, Connecticut Mental Health Center, New Haven 06519, USA.
authors.forename: B E
authors.initials: BE
authors.lastname: Wexler
authors.forename: K A
authors.initials: KA
authors.lastname: Hawkins
authors.forename: B
authors.initials: B
authors.lastname: Rounsaville
authors.forename: M
authors.initials: M
authors.lastname: Anderson
authors.forename: M J
authors.initials: MJ
authors.lastname: Sernyak
authors.forename: M F
authors.initials: MF
authors.lastname: Green
mesh_terms: D000328:Adult; D003071:Cognition; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D012559:Schizophrenia / Q000628:therapy*