title: Physiological effects of platyhelminth FMRF amide-related peptides (FaRPs) on the motility of the monogenean Diclidophora merlangi.
abstract: The actions of known platyhelminth FaRPs on the contractility of whole-worm preparations of the monogenean, Diclidophora merlangi have been examined in vitro for the first time. All of the peptides tested had excitatory effects on the motor activity of the worm. The order of potency for the peptides tested was: YIRFamide > GYIRFamide = RYIRFamide > GNFFRFamide = FLRFamide. However, although YIRFamide was more potent than GYIRFamide, the latter was the most efficacious on each of the motility parameters (tension, contraction amplitude and contraction frequency) examined at concentrations > or = 0.1 microM. Serotonin, which stimulates contractility in the worm was used as a positive control. The excitatory activity of turbellarian and cestode neuropeptides on a monogenean indicates at least some structural similarities in the neuropeptide receptors of these classes of flatworm.
authors.affiliation: Queen's University of Belfast, Medical Biology Centre, Northern Ireland, UK.
authors.forename: C G
authors.initials: CG
authors.lastname: Moneypenny
authors.forename: A G
authors.initials: AG
authors.lastname: Maule
authors.forename: C
authors.initials: C
authors.lastname: Shaw
authors.forename: T A
authors.initials: TA
authors.lastname: Day
authors.forename: R A
authors.initials: RA
authors.lastname: Pax
authors.forename: D W
authors.initials: DW
authors.lastname: Halton
mesh_terms: D000818:Animals; D019835:FMRFamide / Q000494:pharmacology; D005399:Fishes / Q000469:parasitology*; D005880:Gills / Q000469:parasitology; D015801:Helminth Proteins / Q000494:pharmacology; D009068:Movement / Q000187:drug effects; D009479:Neuropeptides / Q000494:pharmacology*; D009842:Oligopeptides / Q000494:pharmacology*; D010986:Platyhelminths / Q000187:drug effects / Q000302:isolation & purification / Q000502:physiology*; D012701:Serotonin / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D015801:Helminth Proteins; D009479:Neuropeptides; D009842:Oligopeptides; C086754:arginyl-tyrosyl-isoleucyl-arginyl-phenylalaninamide; C105067:glycyl-tyrosyl-isoleucyl-arginyl-phenylalaninamide; C109075:tyrosyl-isoleucyl-arginyl-phenylalaninamide; C082029:GNFFRF-amide protein, Moniezia expansa; D012701:Serotonin; D019835:FMRFamide; C066148:phenylalanyl-leucyl-arginyl phenylalaninamide