Fos in locus coeruleus neurons following audiogenic seizure in the genetically epilepsy-prone rat: comparison to electroshock and pentylenetetrazol seizure models.
Seizures in genetically epilepsy-prone rats (GEPRs) may result from hypoactivity of locus coeruleus (LC) neurons during seizures. This study examined Fos-like-immunoreactivity (FLI) in the LC following audiogenic seizures in two strains of GEPRs (GEPR-9s and -3s), and following pentylenetetrazol (PTZ) or maximal electroshock seizures (MES) in normal rats. After tonic seizure, GEPR-9s showed an identical LC-FLI response to that of normal rats following tonic seizures induced by either PTZ or MES. GEPR-3s, having clonic seizures, had less FLI in the LC. Therefore, stimulus-transcription coupling in the GEPR LC is apparently normo-typic in its FLI response to seizure and thus is not likely the root cause of NE abnormalities in this seizure model.
Eells
J B
JB
Department of Physiology, Southern Illinois University School of Medicine at Carbondale, 62901, USA.
Clough
R W
RW
Browning
R A
RA
Jobe
P C
PC
D000818:Animals; D004195:Disease Models, Animal; D004597:Electroshock; D004827:Epilepsy / Q000235:genetics / Q000378:metabolism*; D005260:Female; D008125:Locus Coeruleus / Q000378:metabolism*; D010433:Pentylenetetrazole / Q000494:pharmacology; D016760:Proto-Oncogene Proteins c-fos / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley
D016760:Proto-Oncogene Proteins c-fos; D010433:Pentylenetetrazole