Low frequency of allelic loss in skin tumours from immunosuppressed individuals.
Organ transplant recipients receiving immunosuppression show a dramatically increased risk of non-melanoma skin cancer. The cause of this increase is not known. We report that the rate of loss of heterozygosity (at all the loci we examined) was significantly lower in tumours from immunosuppressed individuals than in tumours from immunocompetent subjects [20 out of 148 (14%) vs 157 out of 428 (37%); P< 0.0001]. These results suggest that tumours in immunosuppressed individuals have a different molecular pathogenesis.
Rehman
I
I
Department of Dermatology, University of Newcastle upon Tyne, UK.
Quinn
A G
AG
Takata
M
M
Taylor
A E
AE
Rees
J L
JL
D000483:Alleles; D002294:Carcinoma, Squamous Cell / Q000235:genetics*; D002874:Chromosome Mapping; D005819:Genetic Markers; D006579:Heterozygote; D006801:Humans; D007165:Immunosuppression Therapy; D018895:Microsatellite Repeats; D017384:Sequence Deletion; D012878:Skin Neoplasms / Q000235:genetics*
D005819:Genetic Markers