Mitochondrial abnormalities and peripheral neuropathy in inflammatory myopathy, especially inclusion body myositis.
Computer retrieval in a database, comprising 7,225 muscle cases, revealed that mitochondrial myopathies do not occur more frequently in inflammatory myopathies (3.74%) than in the whole series (3.69%). A more detailed study of inclusion body myositis (IBM), however, showed that severe mitochondrial alterations were apparent in about twice as many IBM cases as expected. This confirms recent studies of others although a causal relationship has thus far not been established. Identification of mitochondrial deletions by Southern blotting corresponded to the presence of severe structural abnormalities of mitochondria. Peripheral neuropathy of variable severity was noted in all cases of IBM and mitochondrial myopathy. By contrast, the association of severe mitochondrial abnormalities with polymyositis, systemic scleroderma, and vasculitis observed in some cases of the present series may be incidental or age dependent.
Schröder
J M
JM
Institut für Neuropathologie, Universitätsklinikum der RWTH Aachen, Germany.
Molnar
M
M
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004272:DNA, Mitochondrial / Q000235:genetics; D016208:Databases, Factual; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008928:Mitochondria / Q000235:genetics / Q000473:pathology*; D018979:Myositis, Inclusion Body / Q000150:complications / Q000235:genetics / Q000473:pathology* / Q000503:physiopathology; D010523:Peripheral Nervous System Diseases / Q000209:etiology / Q000473:pathology* / Q000503:physiopathology
D004272:DNA, Mitochondrial