title: The histopathological changes in irradiated vs. nonradiated tissue-expanded skin in the porcine model.
abstract: This study examined the histological changes following irradiation on nonexpanded and tissue-expanded pigskin. Six Yorkshire pigs received 4860 cGy radiation to one flank with the opposite side serving as the control. A histopathological comparison of tissue expansion in irradiated tissue to nonradiated tissue showed a reduction in the thickness of the dermal and subcutaneous layers, with less prominent rete ridges and a thicker stratum spinosum (p < 0.05). Nonexpanded irradiated tissue showed a reduction of thickness in the dermis and subcutaneous layer, less prominent rete ridges, and a thicker stratum spinosum layer (p < 0.05) when compared with nonradiated tissue. Tissue-expanded irradiated tissue showed no significant differences (p > 0.05) in any of these parameters when compared with nonexpanded irradiated tissue. This study demonstrates that radiation produced a significant change in porcine skin, but tissue expansion did not further alter the histological changes associated with irradiation.
authors.affiliation: Department of Surgery, St. Michael's Hospital, University of Toronto, Ontario, Canada.
authors.forename: J T
authors.initials: JT
authors.lastname: Kao
authors.forename: A B
authors.initials: AB
authors.lastname: Dagum
authors.forename: J L
authors.initials: JL
authors.lastname: Mahoney
authors.forename: G W
authors.initials: GW
authors.lastname: Gardiner
authors.forename: D
authors.initials: D
authors.lastname: Beaton
mesh_terms: D000818:Animals; D011833:Radiation Injuries, Experimental / Q000473:pathology*; D011855:Radiodermatitis / Q000473:pathology*; D011882:Radiotherapy, High-Energy; D012867:Skin / Q000473:pathology / Q000528:radiation effects; D013552:Swine; D015626:Tissue Expansion