Glutathione metabolism in uremic rat.
The impact of guanidine hydrochloride, a uremic toxin, has been investigated on glutathione mediated antioxidant defense mechanisms in rat liver and kidney. Elevated glutathione-S-transferase (GST) activity in the tissue of guanidine treated rat indicates its active participation in the detoxification of uremic toxin involving glutathione. Glutathione (GSH) is replenished by elevated glutathione reductase and peroxides formed are subsequently detoxified by augumented selenium and non-selenium dependent glutathione peroxidase activities.
Rao
S V
SV
Department of Zoology, S. V. University, Tirupati, India.
Indira
K
K
D000818:Animals; D005978:Glutathione / Q000378:metabolism*; D005979:Glutathione Peroxidase / Q000378:metabolism; D005980:Glutathione Reductase / Q000378:metabolism; D005982:Glutathione Transferase / Q000378:metabolism; D019791:Guanidine / Q000633:toxicity; D007668:Kidney / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D014511:Uremia / Q000139:chemically induced / Q000378:metabolism*
D005979:Glutathione Peroxidase; D005980:Glutathione Reductase; D005982:Glutathione Transferase; D005978:Glutathione; D019791:Guanidine