title: Decreased expression of prostaglandin G/H synthase-2 (PGHS-2) in Alzheimer's disease brain.
authors.affiliation: Department of Neurology, University of Rochester School of Medicine and Dentistry, New York 14642, USA.
authors.forename: M K
authors.initials: MK
authors.lastname: O'Banion
authors.forename: J W
authors.initials: JW
authors.lastname: Chang
authors.forename: P D
authors.initials: PD
authors.lastname: Coleman
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000201:enzymology*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects / Q000627:therapeutic use; D001253:Astrocytes / Q000201:enzymology; D001921:Brain / Q000201:enzymology*; D051546:Cyclooxygenase 2; D052246:Cyclooxygenase 2 Inhibitors; D016861:Cyclooxygenase Inhibitors / Q000009:adverse effects / Q000627:therapeutic use; D006179:Gyrus Cinguli / Q000201:enzymology; D006624:Hippocampus / Q000201:enzymology; D006801:Humans; D007527:Isoenzymes / Q000096:biosynthesis / Q000172:deficiency* / Q000235:genetics; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins / Q000096:biosynthesis / Q000172:deficiency* / Q000235:genetics; D009474:Neurons / Q000201:enzymology*; D011451:Prostaglandin-Endoperoxide Synthases / Q000096:biosynthesis / Q000172:deficiency* / Q000235:genetics; D012333:RNA, Messenger / Q000032:analysis; D013702:Temporal Lobe / Q000201:enzymology
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D052246:Cyclooxygenase 2 Inhibitors; D016861:Cyclooxygenase Inhibitors; D007527:Isoenzymes; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; D012333:RNA, Messenger; D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human; D011451:Prostaglandin-Endoperoxide Synthases