title: Importance of peniscopy, oncologic cytology and histopathology in the diagnosis of penile infection by human papillomavirus.
abstract: BACKGROUND
  Male genital infection by human papillomavirus is of particular importance since it is often asymptomatic. The patient generally presents no clinical lesion. Therefore, men represent an important reservoir of virus, playing a special role in the transmission and perpetuation of the disease.
  
  
  METHODS
  In the present prospective clinical trial study, 190 sex partners of women with genital infection by human papillomavirus, associated or not with cervical intraepithelial neoplasia, were investigated. All patients were unaware of or denied the presence of a genital lesion.
  
  
  RESULTS
  Cytologic examination revealed koilocytosis in 9 cases (4.7%) in the urethra and in 3 cases (1.6%) in the corona of the glans and the distal prepuce. Peniscopy with the previous use of 5% acetic acid revealed white lesions in 97.9% of the patients. Toluidine blue stained most of the lesions. At least one fragment revealed koilocytosis in the histopathologic study of 97 cases (51.05%).
  
  
  CONCLUSIONS
  The three methods complement one another, allowing a more precise diagnosis of the infection in men.
authors.affiliation: Department of Obstetrics and Gynecology, Escola Paulista de Medicina, São Paulo, Brazil.
authors.forename: S M
authors.initials: SM
authors.lastname: Nicolau
authors.forename: N V
authors.initials: NV
authors.lastname: Martins
authors.forename: P E
authors.initials: PE
authors.lastname: Ferraz
authors.forename: J N
authors.initials: JN
authors.lastname: Stávale
authors.forename: W J
authors.initials: WJ
authors.lastname: Gonçalves
authors.forename: E C
authors.initials: EC
authors.lastname: Baracat
authors.forename: G R
authors.initials: GR
authors.lastname: de Lima
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D004197:Disease Reservoirs; D004724:Endoscopy; D006801:Humans; D008297:Male; D008875:Middle Aged; D027383:Papillomaviridae; D030361:Papillomavirus Infections / Q000175:diagnosis* / Q000473:pathology; D010409:Penile Diseases / Q000175:diagnosis* / Q000473:pathology / Q000821:virology*; D011446:Prospective Studies; D014412:Tumor Virus Infections / Q000175:diagnosis* / Q000473:pathology