Effect of stanozolol on body composition, nitrogen balance, and food consumption in castrated dogs with chronic renal failure.
OBJECTIVE
To determine the effect of stanozolol on body composition, nitrogen balance, and food consumption in castrated dogs with chronic renal failure.


METHODS
Blinded crossover trial.


METHODS
22 castrated Beagles with experimentally induced chronic renal failure.


METHODS
Dogs were divided into 2 groups of 11 dogs each. During each of two 6-week treatment periods, dogs in 1 group received stanozolol, and those in the other group received a control agent. Nitrogen balance, body composition, and food consumption were determined.


RESULTS
During administration of stanozolol, the amount of food consumed per dog, lean body mass, and nitrogen balance increased. Stanozolol did not have a significant effect on body fat, bone mineral content, or food consumption per kilogram of body weight.


CONCLUSIONS
For dogs with mild-to-moderate, nonuremic, experimentally induced, chronic renal failure, stanozolol had positive effects on nitrogen balance and lean body mass.
Cowan
L A
LA
Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan 66506, USA.
McLaughlin
R
R
Toll
P W
PW
Brown
S A
SA
Moore
T I
TI
Butine
M D
MD
Milliken
G
G
D045930:Anabolic Agents / Q000494:pharmacology*; D000818:Animals; D001823:Body Composition / Q000187:drug effects* / Q000502:physiology; D002245:Carbon Dioxide / Q000097:blood; D002712:Chlorides / Q000097:blood; D003404:Creatinine / Q000097:blood; D018592:Cross-Over Studies; D004283:Dog Diseases / Q000378:metabolism / Q000503:physiopathology*; D004285:Dogs; D004435:Eating / Q000187:drug effects* / Q000502:physiology; D007676:Kidney Failure, Chronic / Q000378:metabolism / Q000503:physiopathology / Q000662:veterinary*; D008297:Male; D009584:Nitrogen / Q000097:blood / Q000378:metabolism*; D009919:Orchiectomy / Q000662:veterinary; D016037:Single-Blind Method; D013197:Stanozolol / Q000494:pharmacology*
D045930:Anabolic Agents; D002712:Chlorides; D002245:Carbon Dioxide; D013197:Stanozolol; D003404:Creatinine; D009584:Nitrogen