Serious dermatologic reactions in children.
Although serious reactions comprise only a small percentage of total adverse drug reactions, they are important in terms of morbidity and potential mortality. An update on serious dermatologic reactions in children is presented including serum sickness-like reactions due to cefaclor, hypersensitivity syndrome reactions (HSRs), and drug-induced pseudoporphyria. More detailed information on minocycline-induced reactions including drug-induced lupus and HSRs and lamotrigine-induced toxic epidermal necrolysis and Stevens-Johnson syndrome will be discussed.
Knowles
S
S
Department of Clinical Pharmacology, Sunnybrook Health Science Centre, Toronto, Ontario, Canada.
Shapiro
L
L
Shear
N H
NH
D016907:Adverse Drug Reaction Reporting Systems; D000465:Algorithms; D002648:Child; D003663:Decision Trees; D003875:Drug Eruptions / Q000145:classification / Q000175:diagnosis / Q000209:etiology / Q000401:mortality; D006801:Humans; D009017:Morbidity