Corticosteroid effects in skeletal muscle: gene induction/receptor autoregulation.
Common side effects of corticosteroid therapy include muscle weakness and atrophy, which are in part mediated by the induction of the enzyme glutamine synthetase. In addition, corticosteroids autoregulate their own receptor, thereby modulating tissue sensitivity to the hormone. The data in this report demonstrate that these gene-mediated effects are evident in muscle after short-term administration. Determination of molecular response dynamics could be useful in the design of future treatment regimens.
McKay
L I
LI
Department of Biological Sciences, State University of New York at Buffalo, 14260, USA.
DuBois
D C
DC
Sun
Y N
YN
Almon
R R
RR
Jusko
W J
WJ
D000818:Animals; D005786:Gene Expression Regulation / Q000187:drug effects*; D005938:Glucocorticoids / Q000494:pharmacology*; D005974:Glutamate-Ammonia Ligase / Q000235:genetics / Q000378:metabolism; D006706:Homeostasis / Q000502:physiology*; D008297:Male; D008775:Methylprednisolone / Q000494:pharmacology*; D018482:Muscle, Skeletal / Q000187:drug effects* / Q000201:enzymology; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D011965:Receptors, Glucocorticoid / Q000502:physiology*; D013997:Time Factors; D015533:Transcriptional Activation
D005938:Glucocorticoids; D012333:RNA, Messenger; D011965:Receptors, Glucocorticoid; D005974:Glutamate-Ammonia Ligase; D008775:Methylprednisolone