A newly recognized cause of wheezing: AIDS-related bronchial leiomyomas.
We present two human immunodeficiency virus-infected children who developed wheezing and radiological evidence of pulmonary air trapping due to intra- and peribronchial leiomyomas. At autopsy, leiomyomas were also found in their spleens, which to our knowledge, has never been reported. The smooth muscle tumors were strongly positive for the Epstein-Barr virus, as demonstrated by in situ hybridization to Epstein-Barr virus-encoded ribonucleic acid, confirming the findings of recent investigators and linking these tumors to the Epstein-Barr virus.
de Chadarévian
J P
JP
Department of Pathology, St. Christopher's Hospital for Children, Philadelphia, Pennsylvania 19134-1095, USA.
Wolk
J H
JH
Inniss
S
S
Lischner
H W
HW
d'Amore
F
F
Faerber
E N
EN
Isaacson
G C
GC
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D001984:Bronchial Neoplasms / Q000209:etiology* / Q000517:prevention & control / Q000821:virology; D002648:Child; D002675:Child, Preschool; D017809:Fatal Outcome; D004854:Herpesvirus 4, Human / Q000302:isolation & purification; D006801:Humans; D007889:Leiomyoma / Q000209:etiology* / Q000473:pathology / Q000821:virology; D008297:Male; D012135:Respiratory Sounds / Q000209:etiology*