Dopamine and migraine.
This review summarizes a growing body of biological, pharmacologic, and genetic data that support a role for dopamine in the pathophysiology of certain subtypes of migraine. Most migraine symptoms can be induced by dopaminergic stimulation. Moreover, there is dopamine receptor hypersensitivity in migraineurs, as demonstrated by the induction of yawning, nausea, vomiting, hypotension, and other symptoms of a migraine attack by dopaminergic agonists at doses that do not affect nonmigraineurs. Conversely, dopamine receptor antagonists are effective therapeutic agents in migraine. Recent genetic data suggest that molecular variations within dopamine receptor genes play a modifying role in the pathophysiology of migraine with aura. Therefore, modulation of dopaminergic neurotransmission should be considered in the therapeutic management of migraine.
Peroutka
S J
SJ
Spectra Biomedical, Inc., Menlo Park, CA 94025, USA.
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D004298:Dopamine / Q000235:genetics / Q000502:physiology*; D018492:Dopamine Antagonists / Q000627:therapeutic use; D006801:Humans; D008881:Migraine Disorders / Q000188:drug therapy / Q000235:genetics / Q000503:physiopathology*; D009325:Nausea / Q000503:physiopathology; D011954:Receptors, Dopamine / Q000235:genetics / Q000502:physiology; D009435:Synaptic Transmission / Q000502:physiology; D014839:Vomiting / Q000503:physiopathology; D015000:Yawning / Q000187:drug effects
D018492:Dopamine Antagonists; D011954:Receptors, Dopamine; D001058:Apomorphine; D004298:Dopamine