title: Pathological tau proteins in postencephalitic parkinsonism: comparison with Alzheimer's disease and other neurodegenerative disorders.
abstract: Immunohistochemical and biochemical analyses of hyperphosphorylated tau proteins, the major component of neurofibrillary tangles, were performed in different brain regions from patients presenting with postencephalitic parkinsonism. Neurofibrillary tangles were found in hippocampus, neocortical areas (mostly in supragranular layers), and several subcortical structures. By immunoblotting, a tau protein triplet similar to the one seen in Alzheimer's disease was observed. This biochemical approach allows for the definition of postencephalitic parkinsonism from certain neurodegenerative disorders such as progressive supranuclear palsy and corticobasal degeneration.
authors.affiliation: INSERM U422, Hôpital Roger Salengro, Lille, France.
authors.forename: V
authors.initials: V
authors.lastname: Buée-Scherrer
authors.forename: L
authors.initials: L
authors.lastname: Buée
authors.forename: B
authors.initials: B
authors.lastname: Leveugle
authors.forename: D P
authors.initials: DP
authors.lastname: Perl
authors.forename: P
authors.initials: P
authors.lastname: Vermersch
authors.forename: P R
authors.initials: PR
authors.lastname: Hof
authors.forename: A
authors.initials: A
authors.lastname: Delacourte
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000473:pathology*; D004660:Encephalitis / Q000473:pathology*; D006624:Hippocampus / Q000473:pathology; D006801:Humans; D009044:Motor Cortex / Q000473:pathology*; D016874:Neurofibrillary Tangles; D010300:Parkinson Disease / Q000473:pathology*; D013494:Supranuclear Palsy, Progressive / Q000473:pathology; D016875:tau Proteins / Q000032:analysis
chemical_list: D016875:tau Proteins