title: Intravenous cyclosporine therapy in the treatment of pyoderma gangrenosum secondary to Crohn's disease.
abstract: Pyoderma gangrenosum is a destructive, ulcerative skin condition often associated with systemic illnesses such as inflammatory bowel disease, myeloproliferative disorders, and the inflammatory arthritides. We present a patient with long-standing pyoderma gangrenosum associated with Crohn's disease. Multiple deep leg ulcerations were unresponsive over the course of several years to treatment with azathioprine, systemic corticosteroids, 6-mercaptopurine, and dapsone. The patient was hospitalized and treated with a ten-day course of intravenous cyclosporine therapy followed by outpatient oral cyclosporine and showed significant improvement.
authors.affiliation: Department of Dermatology, SUNY-Buffalo 14203, USA.
authors.forename: J M
authors.initials: JM
authors.lastname: Carp
authors.forename: E
authors.initials: E
authors.lastname: Onuma
authors.forename: K
authors.initials: K
authors.lastname: Das
authors.forename: A B
authors.initials: AB
authors.lastname: Gottlieb
mesh_terms: D000328:Adult; D003424:Crohn Disease / Q000150:complications*; D016572:Cyclosporine / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D007262:Infusions, Intravenous; D017511:Pyoderma Gangrenosum / Q000188:drug therapy* / Q000209:etiology* / Q000503:physiopathology; D014945:Wound Healing / Q000187:drug effects
chemical_list: D007166:Immunosuppressive Agents; D016572:Cyclosporine