Regional differences in adipose tissue metabolism between sedentary and endurance-trained women.
Subcutaneous (subc) abdominal and femoral adipose tissue metabolism was studied in sedentary and endurance-trained premenopausal women. Both fat cell weight and lipoprotein lipase (LPL) activity were lower in the subc abdominal depot of trained women compared with controls. Epinephrine- and isoproterenol-stimulated lipolytic responses, as well as the beta-adrenergic sensitivity of subc abdominal adipocytes, were higher in trained than in sedentary women, whereas both the antilipolytic effect of brimonidine (UK-14304) and the alpha 2-adrenoceptor sensitivity were lower in endurance-trained than in sedentary subjects. Maximal lipolysis in the presence of postadrenoceptor agents was also enhanced in subc abdominal adipose cells of trained women compared with sedentary controls. Negative relationships were found between maximal lipolytic responses of subc abdominal fat cells to catecholamines or to postreceptor agents and body fatness as well as abdominal fat distribution indexes. It is concluded that 1) endurance-trained women are characterized by a preferential lipid mobilization from the subc abdominal fat depot, and 2) differences in the metabolic characteristics of subc abdominal adipocytes between trained and sedentary women may involve changes in both LPL activity and the lipolytic cascade that include modifications at receptor and postreceptor levels. However, these alterations appear to be largely resulting from the reduced adipose cell size rather than from exercise training per se.
Mauriège
P
P
Physical Activity Sciences Laboratory, Laval University, Ste-Foy, Québec, Canada.
Prud'Homme
D
D
Marcotte
M
M
Yoshioka
M
M
Tremblay
A
A
Després
J P
JP
D000005:Abdomen; D017667:Adipocytes / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D000273:Adipose Tissue / Q000033:anatomy & histology / Q000378:metabolism*; D000316:Adrenergic alpha-Agonists / Q000494:pharmacology; D000328:Adult; D000704:Analysis of Variance; D000068438:Brimonidine Tartrate; D003994:Bucladesine / Q000494:pharmacology; D002478:Cells, Cultured; D005576:Colforsin / Q000494:pharmacology; D004837:Epinephrine / Q000494:pharmacology; D005080:Exercise Test; D005260:Female; D006801:Humans; D008019:Life Style; D008066:Lipolysis / Q000187:drug effects; D008071:Lipoprotein Lipase / Q000378:metabolism; D010101:Oxygen Consumption; D010807:Physical Endurance / Q000502:physiology*; D010809:Physical Fitness; D011810:Quinoxalines / Q000494:pharmacology; D012044:Regression Analysis; D012119:Respiration; D012867:Skin; D013848:Thigh
D000316:Adrenergic alpha-Agonists; D011810:Quinoxalines; D005576:Colforsin; D000068438:Brimonidine Tartrate; D003994:Bucladesine; D008071:Lipoprotein Lipase; D004837:Epinephrine