Immunohistochemical expression of IL-10 in mycosis fungoides.
Immunoreactivity of the cytokine IL-10 has been investigated in situ in mycosis fungoides (MF). Expression of IL-10 was detected using immunohistochemistry in skin biopsies (n = 8) and T-cell lines (n = 2) from mycosis fungoides patients. IL-10 positivity was seen in the dermal cell infiltrates and in T-cell lines in mycosis fungoides. The dermal IL-10 reaction in a skin biopsy from an active lesion in MF indicates the possibility for disease progression.
Buhl
L
L
Department of Pathology, Vejle Hospital, Denmark.
Søgaard
H
H
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D002461:Cell Line, Transformed; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D016130:Immunophenotyping; D016753:Interleukin-10 / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D009182:Mycosis Fungoides / Q000737:chemistry*; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000737:chemistry*; D013601:T-Lymphocytes / Q000737:chemistry / Q000166:cytology / Q000378:metabolism
D016753:Interleukin-10