Acetylsalicylic acid loaded poly(vinyl alcohol) hemodialysis membranes: effect of drug release on blood compatibility and permeability.
Membranes developed from poly(vinyl alcohol) (PVA) have superior permeability because of the highly hydrophilic character of PVA. However, its blood compatibility needs to be further improved. For this we have developed acetylsalicylic acid (ASA, aspirin) loaded PVA membranes. It seems that the slow release of aspirin from the membrane provides a surface concentration of aspirin sufficient for partially inhibiting platelet adhesion. PVA membrane with 531 micrograms cm-2 of ASA loaded, may be selected for hemodialysis applications. This may help to reduce the amount of heparin infused during hemodialysis, thereby reducing the side-effects associated with the systemic administration of heparin.
Paul
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Division of Biosurface Technology, Sree Chitra Tirunal Institute for Medical Sciences & Technology, Trivandrum, India.
Sharma
C P
CP
D000925:Anticoagulants / Q000008:administration & dosage / Q000009:adverse effects; D001241:Aspirin / Q000378:metabolism* / Q000494:pharmacology; D001672:Biocompatible Materials / Q000592:standards; D001696:Biomechanical Phenomena; D001792:Blood Platelets / Q000187:drug effects; D002448:Cell Adhesion / Q000187:drug effects; D002463:Cell Membrane Permeability / Q000187:drug effects; D003692:Delayed-Action Preparations / Q000378:metabolism; D006493:Heparin / Q000008:administration & dosage / Q000009:adverse effects; D008567:Membranes, Artificial; D010975:Platelet Aggregation Inhibitors / Q000378:metabolism* / Q000494:pharmacology; D011142:Polyvinyl Alcohol / Q000737:chemistry / Q000378:metabolism*; D006435:Renal Dialysis; D013056:Spectrophotometry, Ultraviolet; D013718:Tensile Strength
D000925:Anticoagulants; D001672:Biocompatible Materials; D003692:Delayed-Action Preparations; D008567:Membranes, Artificial; D010975:Platelet Aggregation Inhibitors; D011142:Polyvinyl Alcohol; D006493:Heparin; D001241:Aspirin