Isolation and characterization of novel cytotoxic saponins from Archidendron ellipticum.
A series of new ester saponins, elliptosides A-J, has been isolated from the tropical plant Archidendron ellipticum (Leguminosae). These saponins were particularly cytotoxic to certain renal and melanoma cancer cell lines in the NCI's 60-cell line human tumor screen. The structures of elliptosides A, E, and F were elucidated by spectroscopic and chemical means. Elliptoside A showed in vivo antitumor activity against the LOX melanoma cell line.
Beutler
J A
JA
Laboratory of Drug Discovery Research & Development, National Cancer Institute, Frederick, MD 21702-1201, USA.
Kashman
Y
Y
Pannell
L K
LK
Cardellina
J H
JH
Alexander
M R
MR
Balaschak
M S
MS
Prather
T R
TR
Shoemaker
R H
RH
Boyd
M R
MR
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D007887:Fabaceae / Q000737:chemistry*; D006801:Humans; D008958:Models, Molecular; D010946:Plants, Medicinal; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D016339:Spectrometry, Mass, Fast Atom Bombardment; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000972:Antineoplastic Agents, Phytogenic; D012503:Saponins