Apoptosis in the retina.
An enormous interest in cell death over the past several years has catapulted apoptosis to the forefront of scientific research. Apoptosis has been found to mediate cell deletion in tissue homeostasis, embryological development and immunologic function. It also occurs in pathological situations including cancer and AIDS, and is implicated in a variety of ocular diseases. This review presents a brief history of apoptosis and the proper evidence needed in order to claim that apoptosis is taking place. A summary and critique of important investigations concerning the genetic and biochemical regulation of apoptosis is presented, as well as a focus on other studies drawing a connection between apoptosis and cell death in physiological and pathological situations.
Rosenbaum
P S
PS
Albert Einstein College of Medicine, Bronx, NY, USA.
Gupta
H
H
Savitz
S I
SI
Rosenbaum
D M
DM
D000818:Animals; D017209:Apoptosis; D029742:Caenorhabditis elegans Proteins; D020169:Caspases; D016923:Cell Death; D003546:Cysteine Endopeptidases / Q000502:physiology; D053938:DNA Fragmentation; D010450:Endopeptidases / Q000502:physiology; D006801:Humans; D009419:Nerve Tissue Proteins / Q000502:physiology; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000502:physiology; D012160:Retina / Q000166:cytology / Q000502:physiology* / Q000648:ultrastructure; D012162:Retinal Degeneration / Q000503:physiopathology; D016159:Tumor Suppressor Protein p53 / Q000502:physiology; D053148:Caspase 3
D029742:Caenorhabditis elegans Proteins; D020169:Caspases; D003546:Cysteine Endopeptidases; D010450:Endopeptidases; D009419:Nerve Tissue Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D016159:Tumor Suppressor Protein p53; C089223:ced-3 protein, C elegans; C505410:Casp3 protein, rat; D053148:Caspase 3