title: Cocaine- but not food-seeking behavior is reinstated by stress after extinction.
abstract: Reinstatement of drug-seeking behavior after extinction constitutes a potential animal model of relapse to drug abuse. In a typical reinstatement experiment, previously drug-trained rats undergo extinction during which responding is no longer followed by drug delivery. After significant extinction is observed, rats are then exposed to an event expected to reinstate drug-seeking behavior. Using this procedure, it has been recently reported that footshock stress leads to reinstatement of drug-seeking in heroin-trained, presently drug-free rats. The purpose of the present study was to assess the generality of this effect of stress. Here we report that 15 min of intermittent footshock (0.86 mA; 0.5 s on, with a mean off period of 40 s) reinstated selectively cocaine-seeking behavior after 14 extinction sessions (rats were previously trained on a FR1 TO 20 s to obtain cocaine at a dose of 0.25 mg/infusion). In contrast, under similar experimental conditions, the same stressor did not reinstate food-seeking in food-trained rats after seven extinction sessions (rats were previously trained on a FR1 TO 20 s to obtain six food pellets). Rather, when the basal level of responding was sufficiently high, footshock stress induced a significant suppression of the instrumental performance. These data are discussed in light of several behavioral mechanisms which may explain the specificity of stress in reinstating drug-seeking behavior and not food-seeking behavior.
authors.affiliation: Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92103, USA. aserge@pluto.scripps.edu
authors.forename: S H
authors.initials: SH
authors.lastname: Ahmed
authors.forename: G F
authors.initials: GF
authors.lastname: Koob
mesh_terms: D000818:Animals; D003042:Cocaine; D003216:Conditioning, Operant / Q000502:physiology*; D005108:Extinction, Psychological / Q000502:physiology*; D005247:Feeding Behavior / Q000502:physiology; D008297:Male; D009294:Narcotics; D051381:Rats; D017208:Rats, Wistar; D012646:Self Administration; D013312:Stress, Physiological / Q000503:physiopathology*
chemical_list: D009294:Narcotics; D003042:Cocaine