title: Ewing sarcoma metastatic to the iris.
abstract: OBJECTIVE
  To report a case of Ewing sarcoma metastatic to the iris.
  
  
  METHODS
  A 19-year-old woman with metastatic Ewing sarcoma of the femur developed a diffuse, fluffy iris mass with a pseudohypopyon in the left eye. A fine-needle aspiration biopsy confirmed iris metastasis, and external beam radiotherapy was given to the affected eye.
  
  
  RESULTS
  The iris mass responded initially to external beam radiotherapy and ongoing chemotherapy with vincristine, cyclophosphamide, doxorubicin, etoposide, and ifosfamide but recurred 5 months later. Subsequent radiotherapy with an iodine 125 plaque achieved further resolution of the iris tumor.
  
  
  CONCLUSIONS
  Ewing sarcoma can rarely metastasize to the iris. The diagnosis can be confirmed by fine-needle aspiration biopsy. Plaque radiotherapy is a therapeutic alternative.
authors.affiliation: Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA 19107, USA.
authors.forename: K
authors.initials: K
authors.lastname: Gündüz
authors.forename: J A
authors.initials: JA
authors.lastname: Shields
authors.forename: C L
authors.initials: CL
authors.lastname: Shields
authors.forename: P
authors.initials: P
authors.lastname: De Potter
authors.forename: M J
authors.initials: MJ
authors.lastname: Wayner
mesh_terms: D000328:Adult; D001859:Bone Neoplasms / Q000473:pathology*; D001918:Brachytherapy; D003131:Combined Modality Therapy; D005260:Female; D005269:Femur; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use; D015811:Iris Neoplasms / Q000532:radiotherapy / Q000556:secondary*; D009364:Neoplasm Recurrence, Local; D019233:Retreatment; D012512:Sarcoma, Ewing / Q000532:radiotherapy / Q000556:secondary*
chemical_list: D007457:Iodine Radioisotopes