[The effect of antioxidants on lipid metabolism in myocardium in experimental hyperthyroxinemic conditions].
This experiment was conducted on 38 white Wistar-strain rats subdivided into five experimental groups. Group I were control animals which receiving intraperitoneal 0.5 ml injections of the sodium chloride physiological solution everyday during the whole experimental period of 26 days. Rats from Group II were injected intraperitoneally L-thyroxine (600 micrograms per kg of body weight) five times a week. The animals from Groups III, IV, and V, in addition to thyroxine injected in the same way as in Group II, were additionally administered one of such antioxidants as allopurinol, desferal, or vitamin C. The purpose of this research was to find an answer to the question whether the application of the above-mentioned antioxidants modifies the non-beneficial hyperthyroxinemic impact on the lipid metabolism of the cardiac muscle. It was found that the thyroxine influenced the change of the triglyceride and phospholipid contents in the cardiac muscle. All the applied antioxidants partly modified the thyroxine influence on the lipid balance in the cardiac muscle, especially in the area of triglycerides.
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Katedra Patofizjologii Zakład Patofizjologii Doświadczalnej Collegium Medicum UJ.
Janik
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D000493:Allopurinol / Q000008:administration & dosage; D000818:Animals; D000963:Antimetabolites / Q000008:administration & dosage*; D000975:Antioxidants / Q000008:administration & dosage*; D001205:Ascorbic Acid / Q000008:administration & dosage; D003676:Deferoxamine / Q000008:administration & dosage; D005260:Female; D006321:Heart / Q000187:drug effects*; D006981:Hyperthyroxinemia / Q000139:chemically induced* / Q000378:metabolism; D007274:Injections, Intraperitoneal; D050356:Lipid Metabolism; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D010743:Phospholipids / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D017262:Siderophores / Q000008:administration & dosage; D013974:Thyroxine; D014280:Triglycerides / Q000378:metabolism
D000963:Antimetabolites; D000975:Antioxidants; D010743:Phospholipids; D017262:Siderophores; D014280:Triglycerides; D000493:Allopurinol; D003676:Deferoxamine; D001205:Ascorbic Acid; D013974:Thyroxine