Combination assay for tumor markers in oral squamous cell carcinoma.
OBJECTIVE
This study evaluated use of a combination assay of tumor markers in the diagnosis of oral squamous cell carcinoma.


METHODS
Serum levels of four tumor markers (carcinoembryonic antigen [CEA], squamous cell carcinoma antigen [SCCA], immunosuppressive acidic protein [IAP], and cytokeratin 19 fragment [Cyfra]) were simultaneously measured in 42 patients with oral squamous cell carcinoma (O-SCC) and in 12 patients with oral benign diseases.


RESULTS
The positive rates were 31.0% for CEA, 38.1% for SCCA, 52.4% for IAP, and 38.1% for Cyfra in patients with O-SCC. These rates were significantly different (P < .01) from those of control patients with oral benign diseases. The sensitivity (81.0%) and accuracy (77.8%) of the combination assay uses higher than that obtained with individual markers.


CONCLUSIONS
A combination assay with CEA, SCCA, IAP, and Cyfra may be useful for the screening of patients with suspected oral squamous cell carcinoma.
Kurokawa
H
H
Second Department of Oral and Maxillofacial Surgery, Kyushu Dental College, Kitakyushu, Japan.
Yamashita
Y
Y
Tokudome
S
S
Kajiyama
M
M
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000951:Antigens, Neoplasm / Q000097:blood; D014408:Biomarkers, Tumor / Q000097:blood*; D002272:Carcinoembryonic Antigen / Q000097:blood; D002294:Carcinoma, Squamous Cell / Q000097:blood / Q000175:diagnosis*; D016009:Chi-Square Distribution; D005260:Female; D006801:Humans; D007633:Keratins / Q000097:blood; D008297:Male; D008875:Middle Aged; D009059:Mouth Diseases / Q000097:blood / Q000175:diagnosis; D009062:Mouth Neoplasms / Q000097:blood / Q000175:diagnosis*; D009363:Neoplasm Proteins / Q000097:blood; D012680:Sensitivity and Specificity; D015843:Serpins
D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen; D009363:Neoplasm Proteins; D015843:Serpins; C030193:immunosuppressive acidic protein; C051072:squamous cell carcinoma-related antigen; D007633:Keratins