[The adrenergic reactions to isopropylnoradrenaline in white rats during the development of experimental hyperthyroidism].
In the experiments with white rats injected with atropin the condition of three types of physiological adrenergic reactions was studied (intravenous infusion of isopropylnoradrenaline at a rate of 2.0 micrograms/kg/min): chronotropic reaction of the heart, calorigenic and thermogenic reactions. Experimental hyperthyroidism was caused by subcutaneous injections of thriiodothyronine at a dose of 100 micrograms/kg a day. The results of experiments showed that the changes on the side of chronotropic, calorigenic and thermogenic reactions of catecholamine (isopropylnoradrenaline) are defined by two parabolic functions-one following another with the minimum point (crossing) in the region of 6-7 injections of the hormone. A conclusion is made that the condition of adrenergic physiological reactions during experimental hyperthyroidism at its different stages are different and have a complex character.
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D000318:Adrenergic beta-Agonists / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D001831:Body Temperature / Q000187:drug effects; D004562:Electrocardiography / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D006980:Hyperthyroidism / Q000139:chemically induced / Q000503:physiopathology*; D007545:Isoproterenol / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D018727:Muscarinic Antagonists / Q000494:pharmacology; D051381:Rats; D011943:Receptors, Adrenergic, beta / Q000187:drug effects* / Q000502:physiology; D012007:Rectum; D013997:Time Factors; D014284:Triiodothyronine
D000318:Adrenergic beta-Agonists; D018727:Muscarinic Antagonists; D011943:Receptors, Adrenergic, beta; D014284:Triiodothyronine; D001285:Atropine; D007545:Isoproterenol