Decreases in CD5+ B lymphocytes in children with the DiGeorge anomaly.
The authors evaluated the lymphocyte subsets in eight children with the DiGeorge anomaly, compared with 48 age-matched control infants. Of particular interest was the finding that the percentage and number of CD5+ B lymphocytes were decreased in seven of the eight cases. This observation may provide insight into thymic function and the interaction of the B and T cell systems in some forms of congenital and acquired immunodeficiencies.
Kourtis
A P
AP
Division of Pediatric Infectious Diseases, Epidemiology and Immunology, Emory University, Atlanta, GA 30303, USA.
Ibegbu
C C
CC
Lee
F K
FK
Vogler
L
L
Philips
K
K
Nahmias
A J
AJ
D018941:Antigens, CD19 / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology*; D018956:CD5 Antigens / Q000276:immunology*; D002675:Child, Preschool; D004062:DiGeorge Syndrome / Q000276:immunology*; D005434:Flow Cytometry; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D018655:Lymphocyte Count; D016131:Lymphocyte Subsets
D018941:Antigens, CD19; D018956:CD5 Antigens