[Insulin, steroids and steroidogenesis].
Presented survey summarises insulin-steroid interactions. Beside the well known resistance to insulin induced by steroid hormones, also the central effect of insulin, its influence on the system hypophysis-adrenals, and its stimulatory effect on the generation of steroids in adrenals and ovaries are reviewed. Insulin-steroid interactions are further illustrated by pathogenesis of the polycystic ovary syndrome and by our study on dehydroepiandrosterone regulation. Insulin induced changes in the dehydroepiandrosterone level during the intravenous glucose tolerance test were described.
Svacina
S
S
III. interní klinika 1, lékarské fakulty Univerzity Karlovy, Praha.
Kvapil
M
M
Haas
T
T
Sonka
J
J
D000305:Adrenal Cortex Hormones / Q000096:biosynthesis / Q000502:physiology; D012739:Gonadal Steroid Hormones / Q000096:biosynthesis / Q000502:physiology; D006728:Hormones / Q000096:biosynthesis* / Q000502:physiology; D007328:Insulin / Q000502:physiology*; D007333:Insulin Resistance
D000305:Adrenal Cortex Hormones; D012739:Gonadal Steroid Hormones; D006728:Hormones; D007328:Insulin