[The role of bone morphogenetic proteins in compensatory renal growth].
Bone morphogenetic proteins are members of transforming growth factor beta superfamily. Bone morphogenetic protein-7 (BMP-7) has been recognized as a key signalling molecule during the kidney development and is capable of protecting kidney against acute renal failure in postnatal life. In the present study the involvement of BMP-7 in the kidney compensatory growth after unilateral nephrectomy has been explored. Northern analysis of mRNA from 3 to 21 days after surgery indicated that BMP-7 message was unchanged thus excluding BMP-7 as a compensatory growth agent.
Basić
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Zavod za anatomiju, Medicinski fakultet, Sveuciliste u Zagrebu.
D000222:Adaptation, Physiological; D000818:Animals; D055419:Bone Morphogenetic Protein 7; D019485:Bone Morphogenetic Proteins / Q000494:pharmacology* / Q000502:physiology; D007668:Kidney / Q000254:growth & development*; D008297:Male; D009392:Nephrectomy; D051381:Rats; D017208:Rats, Wistar; D016212:Transforming Growth Factor beta / Q000494:pharmacology
C525821:Bmp7 protein, rat; D055419:Bone Morphogenetic Protein 7; D019485:Bone Morphogenetic Proteins; D016212:Transforming Growth Factor beta