title: Aortic and renal artery thrombosis in a neonate: recovery with thrombolytic therapy.
abstract: This report describes a neonate with acute renal failure associated with extensive aortic and bilateral renal artery thrombosis attributed to inadequate breastfeeding and severe dehydration. Dialytic and general supportive care, together with concurrent anticoagulation, and continuous aggressive intrathrombic instillation of urokinase for 5 days resulted in near-complete thrombolysis. Renal functional recovery began 11 days after the onset of anuria. Despite ischemic atrophy of the left kidney, renal function and blood pressure were normal on follow-up. Thus, in neonates thrombolytic therapy may positively impact survival and recovery of renal function even in the setting of prolonged ischemic renal injury.
authors.affiliation: Division of Pediatric Nephrology, Children's Hospital of Pittsburgh, Pennsylvania 15213, USA.
authors.forename: D
authors.initials: D
authors.lastname: Ellis
authors.forename: R D
authors.initials: RD
authors.lastname: Kaye
authors.forename: F A
authors.initials: FA
authors.lastname: Bontempo
mesh_terms: D001018:Aortic Diseases / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy*; D001027:Aortography; D005343:Fibrinolytic Agents / Q000008:administration & dosage / Q000627:therapeutic use; D006493:Heparin / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D007231:Infant, Newborn; D007262:Infusions, Intravenous; D008297:Male; D012078:Renal Artery Obstruction / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy*; D006435:Renal Dialysis; D015912:Thrombolytic Therapy; D013927:Thrombosis / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy*; D014568:Urokinase-Type Plasminogen Activator / Q000008:administration & dosage / Q000627:therapeutic use
chemical_list: D005343:Fibrinolytic Agents; D006493:Heparin; D014568:Urokinase-Type Plasminogen Activator