title: [Malformations of the midline. A case-control study].
abstract: Defects of the middle line are an heterogeneous group of congenital malformations due to commune pathogenetic mechanisms. We have made a case-control study about 150 newborns, who have at least 1 defect of the middle line. Results prove an excess of males between the cases, due mostly to hypospadias. We haven't found families with defects of the middle line with x-linked manner of hereditary transmission. We haven't found any particular risk present in cases and not in controls. We haven't found any case with 2 or more middle line defects.
authors.affiliation: Divisione Pediatrica, Ospedale S. Andrea di Vercelli, Italia.
authors.forename: A
authors.initials: A
authors.lastname: Guala
authors.forename: G
authors.initials: G
authors.lastname: Pastore
authors.forename: P
authors.initials: P
authors.lastname: Cerruti Mainardi
authors.forename: E
authors.initials: E
authors.lastname: Liverani
authors.forename: T
authors.initials: T
authors.lastname: Ghini
authors.forename: A
authors.initials: A
authors.lastname: Tagliabue
authors.forename: A
authors.initials: A
authors.lastname: Capo
authors.forename: G
authors.initials: G
authors.lastname: Quazza
authors.forename: A C
authors.initials: AC
authors.lastname: Cigolotti
authors.forename: M
authors.initials: M
authors.lastname: Zaffaroni
authors.forename: P
authors.initials: P
authors.lastname: Foracchia
authors.forename: L
authors.initials: L
authors.lastname: Garassino
authors.forename: R
authors.initials: R
authors.lastname: Uasone
mesh_terms: D016022:Case-Control Studies; D002971:Cleft Lip / Q000235:genetics; D002972:Cleft Palate / Q000235:genetics; D000013:Congenital Abnormalities / Q000235:genetics*; D004933:Esophageal Atresia / Q000235:genetics; D004937:Esophageal Fistula / Q000235:genetics; D005260:Female; D005865:Gestational Age; D006801:Humans; D007021:Hypospadias / Q000235:genetics; D007231:Infant, Newborn; D008297:Male; D012737:Sex Factors; D014132:Trachea / Q000002:abnormalities