Structure-absorption relationships of a series of 6-fluoroquinolones.
The physicochemical constants and some structural parameters (topological, steric, and electronic) of eight third-generation monofluorate quinolones (six uncommercialized and two used clinically [ciprofloxacin and enrofloxacin]) were determined: pKa, intrinsic solubility (S0), chromatographic capacity factor, partition coefficient (P), valency molecular connectivity, molecular volume, molecular surface area, dipolar moment, and charges associated with each atom of the molecule. The apparent intestinal absorption rate constants (K(abs)) in rat (in vivo perfusion) and the MICs at which 90% of the isolates are inhibited (MIC90s) against 100 Escherichia coli strains were also determined. We sought to establish simple nonlinear and multiple linear correlations between K(abs), on the one hand, and lipophilic parameters and other physicochemical and structural parameters estimated. Of the nonlinear functions examined, the hyperbolic had the best correlation between K(abs) and P, which was in accordance with the Wagner-Sedman (J. G. Wagner and A. J. Sedman, J. Pharmacokinet. Biopharm. 1:23-50, 1973) equation, whereas, after application of the stepwise multiple linear regression method, a multiple linear correlation with some predictive value could be established only between K(abs) as a dependent variable and log P and log S0 as independent variables. In conclusion, the K(abs) and MIC90 of the quinolone CNV 8902 suggest that it is a sufficiently interesting compound to warrant the investigation of its potential therapeutic use orally.
Escribano
E
E
Unidad de Biofarmacia y Farmacocinética, Facultad de Farmacia, Barcelona, Spain. elvira@farmacia.far.ub.es
Calpena
A C
AC
Garrigues
T M
TM
Freixas
J
J
Domenech
J
J
Moreno
J
J
D000818:Animals; D000890:Anti-Infective Agents / Q000737:chemistry* / Q000493:pharmacokinetics* / Q000494:pharmacology; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002845:Chromatography; D004926:Escherichia coli / Q000187:drug effects; D024841:Fluoroquinolones; D007408:Intestinal Absorption; D007700:Kinetics; D008297:Male; D008826:Microbial Sensitivity Tests; D010477:Perfusion; D051381:Rats; D017207:Rats, Sprague-Dawley; D012995:Solubility; D013329:Structure-Activity Relationship
D000890:Anti-Infective Agents; D024841:Fluoroquinolones