title: 1,3-Dimethylpyrimidoheterocycles as antibacterial agents.
abstract: 1,3-Dimethylbarbituric acid was used as a versatile precursor for the preparation of annelated pyranopyrimidines 2 and 3a-c besides pyrrolopyrimidine 12. The isolated pyrazolopyrimidines 8a-c and 10 and fused pyrazolopyrimidines 14a-d were also synthesized. In addition the new obtained pyrimidoheterocycles were subjected to bacterial testings.
authors.affiliation: Faculty of Science, Al-Mansoura University, Chemistry Department, Egypt.
authors.forename: H H
authors.initials: HH
authors.lastname: Zoorob
authors.forename: M
authors.initials: M
authors.lastname: Abou Elzahab
authors.forename: M
authors.initials: M
authors.lastname: Abdel-Mogib
authors.forename: M A
authors.initials: MA
authors.lastname: Ismail
authors.forename: M
authors.initials: M
authors.lastname: Abdel-Hamid
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D001412:Bacillus subtilis / Q000187:drug effects; D001419:Bacteria / Q000187:drug effects*; D004926:Escherichia coli / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008826:Microbial Sensitivity Tests; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D013055:Spectrophotometry, Infrared
chemical_list: D000900:Anti-Bacterial Agents; D011743:Pyrimidines