Evidence that suppression of IL-1 induced collagenase mRNA expression by dihomo-gamma-linolenic acid (DGLA) involves inhibition of NF kappa B binding.
Borghaei
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Department of Biochemistry/Molecular Biology, Philadelphia College of Osteopathic Medicine, PA 19131, USA.
Borghaei
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RC
Ni
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Pease
E
E
Thornton
R
R
Mochan
E
E
D015126:8,11,14-Eicosatrienoic Acid / Q000494:pharmacology*; D002478:Cells, Cultured; D017364:Collagenases / Q000235:genetics*; D004247:DNA / Q000378:metabolism; D015870:Gene Expression / Q000187:drug effects*; D006801:Humans; D007375:Interleukin-1 / Q000494:pharmacology*; D016328:NF-kappa B / Q000037:antagonists & inhibitors* / Q000378:metabolism; D011401:Promoter Regions, Genetic; D012333:RNA, Messenger / Q000096:biosynthesis*
D007375:Interleukin-1; D016328:NF-kappa B; D012333:RNA, Messenger; D004247:DNA; D017364:Collagenases; D015126:8,11,14-Eicosatrienoic Acid