Synthesis and bone resorption effect of alkoxy-substituted xanthones.
A topological modification of ipriflavone 1, a recent antiosteoporotic drug, is described. The flavone moiety of 1 has been replaced by a xanthone one. Among the new derivatives, the 3,6-diisopropoxyxanthone (2a) has shown significant bone resorption inhibition in in vitro and in vivo tests.
Pifferi
G
G
Institute of Pharmaceutical Chemistry, University of Milan, Italy.
Da Re
P
P
Valenti
P
P
Bisi
A
A
Malandrino
S
S
D000818:Animals; D001862:Bone Resorption / Q000188:drug therapy*; D006801:Humans; D051381:Rats; D014966:Xanthenes / Q000138:chemical synthesis* / Q000494:pharmacology*; D044004:Xanthones
D014966:Xanthenes; D044004:Xanthones; C009689:xanthone