[Injectable phenytoin: problems of stability in solution].
Because of its efficient antiseizure activity, intravenous phenytoin remains a major agent in acute therapy, although it is associated with many pharmacokinetical and toxicological problems. This contribution focuses on the difficulties in finding the appropriate mode of intravenous administration, a matter which is of considerable clinical importance. The fact that precipitations of phenytoin occur when the product is incorrectly diluted is common knowledge--yet the pharmacy department is frequently contacted because of an improper handling of the products available. A review of the factors contributing to precipitation problems, the i.v. products in use in the Grand-Duchy of Luxembourg and the possible i.v. dilutions for these products are discussed.
Francés
A
A
García Martí
A
A
Bruck
M
M
D011232:Chemical Precipitation; D004355:Drug Stability; D006801:Humans; D007275:Injections, Intravenous; D010672:Phenytoin / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics*; D012995:Solubility
D010672:Phenytoin