title: Synthesis and antimicrobial testing of thiazolinyl-, thiazolidinonyl-quinoxalines and 1,2,4-triazolo[4,3-a]quinoxalines.
abstract: Three novel series of quinoxaline derivatives namely 1-substituted amino-4-phenyl-1,2,4-triazolo[4,3-a]quinoxalines 3a-c, 2-[3,4,5-trisubstituted-2,3-dihydrothiazol-2-ylidene) hydrazono]-3-phenylquinoxalines 4a-j, 5a-e, and 2-[(3-substituted-4-oxothiazolidin-2-ylidene) hydrazone]-3-phenylquinoxalines 6a-e have been synthesized by cyclization of the key intermediates 2-substituted thiocarbamoylhydrazino-3-phenylquinoxalines 2a-e. The prepared compounds were tested in vitro for their antimicrobial activity.
authors.affiliation: Pharmaceutical Chemistry Department, Faculty of Pharmacy, University of Alexandria, Egypt.
authors.forename: N S
authors.initials: NS
authors.lastname: Habib
authors.forename: S A
authors.initials: SA
authors.lastname: el-Hawash
mesh_terms: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D011810:Quinoxalines / Q000138:chemical synthesis* / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D014230:Triazoles / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D011810:Quinoxalines; D013844:Thiazoles; D014230:Triazoles