Persistent chlorpromazine deposits in donor corneal tissue after corneal transplantation.
OBJECTIVE
To present unusual cases with corneal graft deposits and discuss eye bank criteria concerning donors treated with phenothiazines.


METHODS
We examined two patients with unusual corneal graft deposits after uneventful corneal transplantation. Donors' files and eye bank procedures were reviewed.


RESULTS
Fine corneal endothelial punctate deposits were detected in both corneal grafts and did not resolve in the following 18 months.


CONCLUSIONS
To our knowledge, this is the first case report documenting transplantation of corneas with chlorpromazine deposits. Delicate corneal findings can be missed before transplantation.
Cahane
M
M
Goldschleger Eye Institute, Sheba Medical Center, Tel-Hashomer, Israel.
Chen
V
V
Avni
I
I
D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects*; D002746:Chlorpromazine / Q000009:adverse effects*; D003315:Cornea / Q000187:drug effects* / Q000473:pathology / Q000601:surgery; D003316:Corneal Diseases / Q000139:chemically induced* / Q000473:pathology / Q000601:surgery; D016039:Corneal Transplantation; D004728:Endothelium, Corneal / Q000187:drug effects / Q000378:metabolism; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D014019:Tissue Donors
D014150:Antipsychotic Agents; D002746:Chlorpromazine