title: Functional imaging of headache - first steps in an objective quantitative classification of migraine.
abstract: A highly sensitive quantitative-topographical EEG was used in order to define first steps in an objective classification of migraine. A 17-channel quantitative EEG was recorded in 30 patients suffering from migraine with or without aura during the painfree interval. These EEG s were compared to EEGs of age related healthy norm groups using a new statistical tool called the Aberration Index. A focal aberration in the area of pain was detected in 26 out of the 30 patients mostly due to an increase of alpha1 EEG power (23 patients). Alpha2 or theta power were also increased in several patients. Furthermore, a decrease in alpha power neighbouring the focus was found in 18 patients and a contralateral reduction of alpha power was seen in 16 patients. No difference was detected between migraine with aura and migraine without aura.
authors.affiliation: Pro Science Private Research Institute GmbH, med. Forschung und Entwicklung, Kurt-Schumacher-Str. 9, Linden D-35440, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Sauer
authors.forename: R
authors.initials: R
authors.lastname: Schellenberg
authors.forename: H C
authors.initials: HC
authors.lastname: Hofmann
authors.forename: W
authors.initials: W
authors.lastname: Dimpfel
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000513:Alpha Rhythm; D001931:Brain Mapping; D016022:Case-Control Studies; D003495:Cyclandelate / Q000627:therapeutic use; D004569:Electroencephalography / Q000379:methods* / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D008875:Middle Aged; D008881:Migraine Disorders / Q000145:classification* / Q000188:drug therapy / Q000503:physiopathology*; D012680:Sensitivity and Specificity; D013826:Theta Rhythm; D014665:Vasodilator Agents / Q000627:therapeutic use
chemical_list: D014665:Vasodilator Agents; D003495:Cyclandelate