Periventricular heterotopias display cortical degenerative neuropathology.
This report describes beta-amyloid plaques in periventricular heterotopias in two elderly women. The neuropathologic features of the heterotopias recapitulated those of nearby neocortex but were distinct from those of adjacent caudate nucleus. In response to the factors important in plaque and tangle formation, the heterotopias biologically behave like neocortex and unlike adjacent striatum, further supporting the morphologic evidence that these tissues represent heterotopic cortex.
Joseph
J T
JT
Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
D000368:Aged; D000544:Alzheimer Disease / Q000473:pathology; D002421:Caudate Nucleus / Q000473:pathology; D002540:Cerebral Cortex / Q000473:pathology*; D002552:Cerebral Ventricles / Q000473:pathology*; D002828:Choristoma / Q000473:pathology*; D003704:Dementia / Q000473:pathology*; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D009778:Occipital Lobe / Q000473:pathology