title: X-ray phototherapy for canine brain masses.
abstract: Brain masses diagnosed in 47 pet dogs as tumors by CT scans, and confirmed in 12 dogs by necropsies, were injected with iodinated contrast media and treated by a modified CT scanner, the CTRx. Twenty-six dogs that received six or more weekly treatments of about 5.6 Gy per fraction, of which about 25% was contributed by radiation from the iodine, for a median total dose of 39 Gy, had a median survival of 230 days. This compares well with the 150 days reported for 25 dogs given 46-48 Gy of cobalt-60 radiation to the whole brain, and is significantly greater than the 6 to 13 days in untreated historic controls.
authors.affiliation: Department of Radiation Oncology, UCLA School of Medicine 90095-1721 USA. anorman@ucla.edu
authors.forename: A
authors.initials: A
authors.lastname: Norman
authors.forename: M
authors.initials: M
authors.lastname: Ingram
authors.forename: R G
authors.initials: RG
authors.lastname: Skillen
authors.forename: D B
authors.initials: DB
authors.lastname: Freshwater
authors.forename: K S
authors.initials: KS
authors.lastname: Iwamoto
authors.forename: T
authors.initials: T
authors.lastname: Solberg
mesh_terms: D000818:Animals; D001254:Astrocytoma / Q000401:mortality / Q000532:radiotherapy / Q000662:veterinary*; D001706:Biopsy; D001932:Brain Neoplasms / Q000401:mortality / Q000532:radiotherapy / Q000662:veterinary*; D004283:Dog Diseases / Q000401:mortality / Q000532:radiotherapy*; D004285:Dogs; D008577:Meningeal Neoplasms / Q000401:mortality / Q000532:radiotherapy / Q000662:veterinary*; D008579:Meningioma / Q000401:mortality / Q000532:radiotherapy / Q000662:veterinary*; D009929:Organ Size; D011829:Radiation Dosage; D011897:Random Allocation; D015996:Survival Rate; D014057:Tomography, X-Ray Computed / Q000662:veterinary; D014964:X-Ray Therapy / Q000662:veterinary