Malaria sporozoites and chylomicron remnants compete for binding sites in the liver.
Like Malaria sporozoites and the circumsporozoite protein, remnants of lipoproteins are rapidly cleared from the circulation and enter hepatocytes. Here we review the evidence that the same set of liver heparan sulfate proteoglycans are the initial binding sites of malaria sporozoites and the lipoprotein remnants.
Nussenzweig
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Division of Immunology, New York University Medical Center, NY 10016, USA.
D000595:Amino Acid Sequence; D000818:Animals; D000953:Antigens, Protozoan / Q000737:chemistry / Q000378:metabolism; D001665:Binding Sites; D002914:Chylomicrons / Q000378:metabolism*; D019812:Heparan Sulfate Proteoglycans / Q000378:metabolism*; D006790:Host-Parasite Interactions; D006801:Humans; D008099:Liver / Q000378:metabolism*; D008288:Malaria / Q000503:physiopathology*; D008969:Molecular Sequence Data; D010961:Plasmodium; D015800:Protozoan Proteins / Q000737:chemistry / Q000378:metabolism*; D016415:Sequence Alignment
D000953:Antigens, Protozoan; D002914:Chylomicrons; D019812:Heparan Sulfate Proteoglycans; D015800:Protozoan Proteins; C041595:circumsporozoite protein, Protozoan