title: Time-dependent blockade of STP and LTP in hippocampal slices following acute stress in mice.
abstract: The characteristics of short-term potentiation (STP) and long-term potentiation (LTP) in the CA1 region of hippocampal slices were determined at various times following exposure to acute stress produced by restraint and tail-shock in mice. In slices prepared from control animals, theta-burst stimulation resulted in a large increase in evoked field excitatory postsynaptic potentials (EPSPs) amplitude and slope that remained stable at least up to 30 min after stimulation. Slices prepared 1 h after stress exhibited a marked decrease in the extent of both STP and LTP. STP and LTP magnitude were still significantly decreased 24 h after stress exposure and were completely restored to control levels by 48 h. These results provide evidence for a reversible impairment of STP and LTP in CA1 following an acute episode of stress, and suggest that stress activates processes different from those activated by LTP-inducing stimuli.
authors.affiliation: Laboratoire de Neurosciences Comportementales et Cognitives, CNRS URA 339, Université de Bordeaux, Talence, France. garcia@neurocog.u-bordeaux.fr
authors.forename: R
authors.initials: R
authors.lastname: Garcia
authors.forename: W
authors.initials: W
authors.lastname: Musleh
authors.forename: G
authors.initials: G
authors.lastname: Tocco
authors.forename: R F
authors.initials: RF
authors.lastname: Thompson
authors.forename: M
authors.initials: M
authors.lastname: Baudry
mesh_terms: D000818:Animals; D006624:Hippocampus / Q000502:physiology*; D017774:Long-Term Potentiation / Q000502:physiology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D013312:Stress, Physiological / Q000503:physiopathology*; D009435:Synaptic Transmission / Q000502:physiology; D013997:Time Factors