Efficacy of trovafloxacin for treatment of experimental Bacteroides infection in young and senescent mice.
We investigated the efficacy of trovafloxacin, a new quinolone, in comparison with that of clindamycin in the treatment of intra-abdominal abscesses caused by Bacteroides fragilis in young and senescent mice. The development of abscess formation, the number of viable organisms, and antibiotic concentrations were measured, and the values for young and old mice were compared. Trovafloxacin was well distributed to the tissues in both young and old animals. Although the pharmacokinetics and concentrations of trovafloxacin in serum were similar between young and old mice, the levels in tissue were higher in senescent mice than in young mice. Trovafloxacin therapy sterilized abscesses in 94% of young mice and in 73% of old mice, but this difference was not significant. This therapeutic response to trovafloxacin was similar to that seen with clindamycin. These results suggest that aging may not have any adverse effect on the therapeutic outcome for intra-abdominal abscesses caused by B. fragilis.
Thadepalli
H
H
Division of Geriatrics and Gerontology, Charles R. Drew University of Medicine and Science, Los Angeles, California 90059, USA.
Chuah
S K
SK
Reddy
U
U
Hanna
N
N
Clark
R
R
Polzer
R J
RJ
Gollapudi
S
S
D018784:Abdominal Abscess / Q000097:blood / Q000188:drug therapy* / Q000378:metabolism; D000375:Aging / Q000097:blood / Q000378:metabolism / Q000502:physiology*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000097:blood / Q000493:pharmacokinetics / Q000494:pharmacology*; D001442:Bacteroides Infections / Q000097:blood / Q000188:drug therapy* / Q000378:metabolism; D002981:Clindamycin / Q000494:pharmacology; D024841:Fluoroquinolones; D008297:Male; D051379:Mice; D009287:Naphthyridines / Q000097:blood / Q000493:pharmacokinetics / Q000494:pharmacology*; D014018:Tissue Distribution
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D009287:Naphthyridines; D002981:Clindamycin; C080163:trovafloxacin