title: Calx, a Na-Ca exchanger gene of Drosophila melanogaster.
abstract: We have cloned Calx, a gene that encodes a Na-Ca exchanger of Drosophila melanogaster. Calx encodes two repeated motifs, Calx-alpha and Calx-beta, that overlap domains required for exchanger activity and regulation. Calx has multiple transcripts in adults, including at least one expressed in the retina. The Calx genomic locus comprises >/=35 kb between the Atpalpha and rudimentary-like genes in chromosomal region 93B. In Xenopus oocytes, microinjected Calx cRNA induces calcium uptake like that of its homolog, the 3Na+-1Ca2+ exchanger of mammalian heart. Implications of Calx-alpha motifs for the mechanism of Na-Ca exchange are discussed.
authors.affiliation: Division of Biology, 156-29, California Institute of Technology, Pasadena, CA 91125, USA.
authors.forename: E M
authors.initials: EM
authors.lastname: Schwarz
authors.forename: S
authors.initials: S
authors.lastname: Benzer
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D017920:Antiporters; D002352:Carrier Proteins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D003001:Cloning, Molecular; D018076:DNA, Complementary; D029721:Drosophila Proteins; D004331:Drosophila melanogaster / Q000235:genetics*; D008969:Molecular Sequence Data; D017386:Sequence Homology, Amino Acid
chemical_list: D017920:Antiporters; C108396:Calx protein, Drosophila; D002352:Carrier Proteins; D018076:DNA, Complementary; D029721:Drosophila Proteins