title: The effect of fluoxetine on sleep EEG in childhood depression: a preliminary report.
abstract: Fluoxetine is associated with substantial objective and subjective sleep disturbance in adults with major depressive disorders. In this preliminary report, the effects of fluoxetine on sleep electroencephologram (EEG) are described in 6 children and adolescents with nonpsychotic major depression. Fluoxetine increased light Stage 1 sleep, the number of arousals and rapid eye movement (REM) density. REM latency was largely unaffected. Oculomotor abnormalities were also evident on treatment, accompanied by an increase in myoclonic activity. Subjective sleep was also disturbed on treatment. These results are in keeping with those observed in depressed adults treated with fluoxetine.
authors.affiliation: University of Texas Southwestern Medical Center, Department of Psychiatry, Dallas 75235-9070, USA.
authors.forename: R
authors.initials: R
authors.lastname: Armitage
authors.forename: G
authors.initials: G
authors.lastname: Emslie
authors.forename: J
authors.initials: J
authors.lastname: Rintelmann
mesh_terms: D000293:Adolescent; D018687:Antidepressive Agents, Second-Generation / Q000009:adverse effects* / Q000627:therapeutic use; D001143:Arousal / Q000187:drug effects; D001322:Autoanalysis; D002648:Child; D003866:Depressive Disorder / Q000150:complications* / Q000188:drug therapy / Q000523:psychology; D004569:Electroencephalography / Q000187:drug effects*; D005260:Female; D005473:Fluoxetine / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D017286:Polysomnography; D011569:Psychiatric Status Rating Scales; D012893:Sleep Wake Disorders / Q000139:chemically induced* / Q000523:psychology; D012895:Sleep, REM / Q000187:drug effects
chemical_list: D018687:Antidepressive Agents, Second-Generation; D005473:Fluoxetine