title: Prognostic indicators for squamous cell carcinoma of the oral cavity: a clinicopathologic correlation.
abstract: Fifty-three patients with T1 squamous cell cancer of the floor of mouth and ventral surface of the tongue with a known clinical outcome were retrospectively analyzed and arbitrarily divided into "aggressive" and "nonaggressive" groups based on their clinical behavior. Various host and tumor factors were then evaluated in an attempt to determine whether the tumor behavior could have been predicted. The paraffin-embedded tumor specimens were evaluated for tumor differentiation, tumor thickness and tumor invasion, microvessel density, and p53 expression. In addition, a composite morphologic grading score was obtained by combining cell differentiation, nuclear polymorphism, mitosis activity, depth of infiltration, type of infiltration, and lymphatic infiltration. No single technique appeared capable of identifying "aggressive" behavior, although possibly an evaluation of composite factors might show promise in the future.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, University of Cincinnati, Ohio, U.S.A.
authors.forename: J L
authors.initials: JL
authors.lastname: Gluckman
authors.forename: Z P
authors.initials: ZP
authors.lastname: Pavelic
authors.forename: H J
authors.initials: HJ
authors.lastname: Welkoborsky
authors.forename: W
authors.initials: W
authors.lastname: Mann
authors.forename: P
authors.initials: P
authors.lastname: Stambrook
authors.forename: L
authors.initials: L
authors.lastname: Gleich
authors.forename: K
authors.initials: K
authors.lastname: Wilson
authors.forename: P
authors.initials: P
authors.lastname: Righi
authors.forename: L G
authors.initials: LG
authors.lastname: Portugal
authors.forename: J
authors.initials: J
authors.lastname: McDonald
authors.forename: P
authors.initials: P
authors.lastname: Biddinger
authors.forename: D
authors.initials: D
authors.lastname: Steward
authors.forename: P
authors.initials: P
authors.lastname: Gartside
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000473:pathology* / Q000628:therapy; D002454:Cell Differentiation; D002467:Cell Nucleus / Q000648:ultrastructure; D005260:Female; D005500:Follow-Up Studies; D005544:Forecasting; D015972:Gene Expression Regulation, Neoplastic; D016158:Genes, p53 / Q000235:genetics; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D008207:Lymphatic Metastasis / Q000473:pathology; D008297:Male; D008833:Microcirculation / Q000473:pathology; D008875:Middle Aged; D008938:Mitosis; D009060:Mouth Floor / Q000473:pathology; D009062:Mouth Neoplasms / Q000098:blood supply / Q000473:pathology* / Q000628:therapy; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D009367:Neoplasm Staging; D016612:Paraffin Embedding; D011379:Prognosis; D012189:Retrospective Studies; D014062:Tongue Neoplasms / Q000098:blood supply / Q000473:pathology* / Q000628:therapy; D016896:Treatment Outcome