title: The effect of priming with vecuronium and rocuronium on young and elderly patients.
abstract: The priming principle consists of administering a subparalyzing dose of nondepolarizing neuromuscular blocking drug 3-6 min before giving a second dose for tracheal intubation. This study was performed to observe the effects of priming doses of vecuronium and rocuronium on pulmonary function tests and muscular weaknesses in young (25-35 yr of age) and elderly (65-73 yr of age) patients. Ten young and 10 elderly patients were each placed in vecuronium and rocuronium groups. Oxygen saturation and train-of-four (TOF) ratio were determined, and pulmonary function tests were performed. Then 20% of the 95% effective dose (ED95) of the muscle relaxants was given intravenously. All tests were performed again 4 min after vecuronium and 3 min after rocuronium. Other signs of muscular weaknesses were also recorded. Elderly patients showed more signs of muscle weakness in both groups. The TOF ratio was 0.77 and 0.79 in the elderly rocuronium and vecuronium groups, respectively, and 0.89 and 0.90 in the young rocuronium and vecuronium groups, respectively. Dynamic spirometry revealed decreases in forced expiratory volume in 1 s and forced vital capacity in both groups, and no significant changes in peak expiratory flow rate. The expiratory reserve volume was reduced more in the elderly groups. Oxygen saturation decreased in both groups. We conclude that oxygen saturation, pulmonary function, and muscle strength decrease more in the elderly than in their younger counterparts from priming doses of vecuronium or rocuronium.
  
  
  CONCLUSIONS
  The priming principle consists of giving a subparalyzing dose of muscle relaxant 3-6 min before giving a second dose for tracheal intubation. We found that priming doses of vecuronium and rocuronium produced greater decreases in oxygen saturation and pulmonary function in the elderly (aged 65-73 yr) than their younger (aged 25-35 yr) counterparts. Priming may not be a safe approach in elderly patients.
authors.affiliation: Department of Anesthesiology, Dhaka Medical College Hospital, Bangladesh.
authors.forename: L
authors.initials: L
authors.lastname: Aziz
authors.forename: S M
authors.initials: SM
authors.lastname: Jahangir
authors.forename: S N
authors.initials: SN
authors.lastname: Choudhury
authors.forename: K
authors.initials: K
authors.lastname: Rahman
authors.forename: Y
authors.initials: Y
authors.lastname: Ohta
authors.forename: M
authors.initials: M
authors.lastname: Hirakawa
mesh_terms: D000328:Adult; D000368:Aged; D000732:Androstanols / Q000008:administration & dosage* / Q000009:adverse effects; D000758:Anesthesia; D005260:Female; D006801:Humans; D007442:Intubation, Intratracheal; D008297:Male; D018908:Muscle Weakness / Q000139:chemically induced; D003473:Neuromuscular Nondepolarizing Agents / Q000008:administration & dosage*; D010100:Oxygen / Q000097:blood; D015656:Respiratory Mechanics / Q000187:drug effects; D000077123:Rocuronium; D014673:Vecuronium Bromide / Q000008:administration & dosage* / Q000009:adverse effects
chemical_list: D000732:Androstanols; D003473:Neuromuscular Nondepolarizing Agents; D014673:Vecuronium Bromide; D010100:Oxygen; D000077123:Rocuronium