In-vivo and in-vitro sensitivity of Plasmodium falciparum to chloroquine in Chennai (Tamil Nadu), India.
In-vitro and in-vivo susceptibility of Plasmodium falciparum to chloroquine were conducted at Chennai city, India. Eighteen (60%) out of 30 cases showed resistance in in-vitro study. EC50 of resistant and sensitive cases were 0.40 and 0.24 mumol chloroquine/l blood respectively, while EC90 were 2.64 and 0.84 mumol chloroquine/l blood respectively. In-vivo tests identified 24 cases (40%) as resistant (23 RI and 1 RII) and 36 (60%) as sensitive out of 60 cases. Eight isolates which were found resistant with in-vitro tests showed sensitive behaviour to chloroquine treatment assessed by in-vivo studies.
Dua
V K
VK
Malaria Research Centre (Field Station), Sector III, Ranipur, Hardwar, India.
Kar
P K
PK
Gupta
N C
NC
Kar
I
I
Sharma
V P
VP
D000293:Adolescent; D000328:Adult; D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D002738:Chloroquine / Q000494:pharmacology*; D005260:Female; D006801:Humans; D016778:Malaria, Falciparum / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D010963:Plasmodium falciparum / Q000187:drug effects*
D000962:Antimalarials; D002738:Chloroquine