title: Brain-derived neurotrophic factor in human platelets.
abstract: A sensitive, capture enzyme-linked immunosorbent assay (CELISA) has been applied to the accurate and reproducible measurement of brain-derived neurotrophic factor (BDNF) protein in normal human blood platelets, a mean concentration of 1.03 +/- 0.04 ng (SEM)/mg of platelet protein being observed. The method, which requires only 10 ml blood, is now suitable for the investigation of a variety of clinical disorders.
authors.affiliation: Department of Biochemistry, Imperial College of Science, Technology and Medicine, London, UK.
authors.forename: F B
authors.initials: FB
authors.lastname: Pliego-Rivero
authors.forename: N
authors.initials: N
authors.lastname: Bayatti
authors.forename: X
authors.initials: X
authors.lastname: Giannakoulopoulos
authors.forename: V
authors.initials: V
authors.lastname: Glover
authors.forename: H F
authors.initials: HF
authors.lastname: Bradford
authors.forename: G
authors.initials: G
authors.lastname: Stern
authors.forename: M
authors.initials: M
authors.lastname: Sandler
mesh_terms: D001792:Blood Platelets / Q000378:metabolism*; D019208:Brain-Derived Neurotrophic Factor / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods*; D006801:Humans
chemical_list: D019208:Brain-Derived Neurotrophic Factor