[The prognostic significance of the morphological type of chronic glomerulonephritis and of the tubulointerstitial changes depending on the clinical type of the disease].
The review of 200 cases of chronic glomerulonephritis (CG) led the authors to the conclusion that there is a statistically significant relationship between rapid progression (RP) of the disease (onset of chronic renal failure within 7 years since the diagnosis) and its morphological type (chi 2 = 37), tubulointerstitial changes (chi 2 = 34; p < 0.0000), clinical disease types according to M. Ia. Ratner, V. V. Serov et al. (chi 2 = 115; p < 0.0000). In both prognostically favourable and unfavorable morphological types RP occurred more frequently in concurrent unfavorable clinical types (chi 2 = 19; p < 0.0001). In prognostically unfavorable morphological types there were, as a rule, unfavorable clinical types, whereas in favorable ones-favorable clinical types. In the presence of tubulointerstitial changes RP occurred primarily in unfavorable clinical types which are encountered in these morphological changes significantly more frequently than in their absence (chi 2 = 48; p < 0.01). RP of CG in prognostically unfavorable morphological types and tubulointerstitial changes depends mainly on accompanying clinical types of CG.
Ratner
M Ia
MIa
Fedorova
N D
ND
D000293:Adolescent; D000328:Adult; D016009:Chi-Square Distribution; D002908:Chronic Disease; D018450:Disease Progression; D005260:Female; D005921:Glomerulonephritis / Q000145:classification / Q000150:complications / Q000473:pathology*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000209:etiology; D008297:Male; D008875:Middle Aged; D009395:Nephritis, Interstitial / Q000145:classification / Q000150:complications / Q000473:pathology*; D011379:Prognosis; D013997:Time Factors