Noninsulin-dependent diabetes mellitus-related encephalopathy presenting with amnesia, personality change, and autonomic seizure.
We describe a patient with noninsulin-dependent diabetes mellitus presenting with an amnestic disorder, personality change, and autonomic seizure. Magnetic resonance images of the brain showed T2-high signal lesion in the hippocampi bilaterally and nonspecific white matter disease, while single photon emission computed tomography revealed a diffuse reduction of cerebral blood flow. Sensory and auditory evoked potentials revealed delayed impulse conduction velocities in the central nervous system. Degenerative changes caused by a microvascular angiopathy related to noninsulin-dependent diabetes mellitus may underlie the central nervous system manifestations in our patient.
Kashihara
K
K
Department of Neurology, Okayama University Medical School.
Shohmori
T
T
Otsuki
S
S
D000200:Action Potentials / Q000502:physiology; D000328:Adult; D000647:Amnesia / Q000175:diagnosis*; D001342:Autonomic Nervous System Diseases / Q000175:diagnosis*; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology; D001927:Brain Diseases / Q000150:complications*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D003929:Diabetic Neuropathies / Q000150:complications; D003937:Diagnosis, Differential; D005072:Evoked Potentials, Auditory / Q000502:physiology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D010554:Personality Disorders / Q000175:diagnosis*; D011859:Radiography; D011877:Radionuclide Imaging; D012640:Seizures / Q000150:complications*