[The effect of thymogen on the heart in ischemia and reperfusion].
The anti-ischemic properties of thymogen were studied on an isolated heart model. Its cardioprotective effect was higher than that of dalargin and verapamil. The mechanism of the thymogen anti-ischemic action is realized without the participation of the opiate receptors and blockade of calcium entrance into the cardiomyocytes.
Filippova
O V
OV
Reznikov
K M
KM
Alabovskił
V V
VV
Khamburov
V V
VV
Vinokurov
A A
AA
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology* / Q000627:therapeutic use; D002118:Calcium / Q000378:metabolism; D004151:Dipeptides; D016308:Enkephalin, Leucine-2-Alanine / Q000031:analogs & derivatives / Q000378:metabolism / Q000494:pharmacology; D006321:Heart / Q000187:drug effects*; D066298:In Vitro Techniques; D008274:Magnesium / Q000378:metabolism; D009200:Myocardial Contraction / Q000187:drug effects; D017202:Myocardial Ischemia / Q000188:drug therapy*; D015428:Myocardial Reperfusion Injury / Q000188:drug therapy*; D009206:Myocardium / Q000166:cytology / Q000473:pathology; D009211:Myoglobin / Q000378:metabolism; D009270:Naloxone / Q000378:metabolism / Q000494:pharmacology; D009292:Narcotic Antagonists / Q000378:metabolism / Q000494:pharmacology; D010455:Peptides / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D014700:Verapamil / Q000378:metabolism / Q000494:pharmacology
D000889:Anti-Arrhythmia Agents; D004151:Dipeptides; D009211:Myoglobin; D009292:Narcotic Antagonists; D010455:Peptides; C060736:thymogen; D009270:Naloxone; D016308:Enkephalin, Leucine-2-Alanine; D014700:Verapamil; D008274:Magnesium; D002118:Calcium; C040996:enkephalin-Leu, Ala(2)-Arg(6)-