In vitro susceptibilities to amphotericin B, itraconazole, and miconazole of filamentous fungi isolated from patients with cystic fibrosis.
The antimicrobial activities of amphotericin B, itraconazole, and miconazole against 101 filamentous fungi from patients with cystic fibrosis were tested by a reproducible microdilution method. Itraconazole was very active against Aspergillus species and Scedosporium species (MIC at which 90% of the isolates were inhibited [MIC90], 0.06 to 0.5 mg/liter), whereas amphotericin B was less effective (MIC90, 0.5 to 8 mg/liter).
Hennequin
C
C
Laboratoire de Parasitologie, Service de Microbiologie, Hôpital Necker-Enfants Malades, Paris, France.
Benailly
N
N
Silly
C
C
Sorin
M
M
Scheinmann
P
P
Lenoir
G
G
Gaillard
J L
JL
Berche
P
P
D000666:Amphotericin B / Q000494:pharmacology; D000935:Antifungal Agents / Q000494:pharmacology*; D001230:Aspergillus / Q000187:drug effects*; D003550:Cystic Fibrosis / Q000382:microbiology*; D017964:Itraconazole / Q000494:pharmacology; D008825:Miconazole / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D003904:Mitosporic Fungi / Q000187:drug effects*
D000935:Antifungal Agents; D017964:Itraconazole; D008825:Miconazole; D000666:Amphotericin B