[Clinical assessment of myocardial protection with blood-GIK solution].
Since Jan, 1984, three different types of myocardial protection have been tried in coronary bypass surgery. These are GIK (1984. 1-1984. 12), Young+GIK (1985. 1-1986. 8), and blood GIK (1986. 9-until present). In this study we tried to demonstrate the advantage of myocardial protection induced with blood GIK solution in comparison with that with GIK alone or Young + GIK. (Materials and methods) Eighty-three patients undergone coronary bypass surgery in that period, were evaluated and divided into three groups: Group I had myocardial protection with GIK alone in 24 patients, group II had myocardial protection with Young + GIK in 28 patients, and group III had myocardial protection with Young + blood GIK in 31 patients. Among these groups, the changes of serum enzymes and hemodynamics in postoperative period were compared. (Results) In the hemodynamic changes, cardiac index at 24 hours after operation in group III, was higher than that in the other two groups (p < 0.05). The peak value of MB-CPK in all groups appeared 12 hours after operation, however, 21.9 +/- 19.72 IU/ml in group III was significantly lower than 33.4 +/- 25.5 in group I, or 36.9 +/- 26.8 in group II (p < 0.01). The results demonstrates that the myocardial protection induced with blood GIK are superior to these with the other two method.
Koyama
N
N
Watanabe
Y
Y
Yoshihara
K
K
Tokuhiro
K
K
Horikoshi
J
J
Tanaka
T
T
Shiono
N
N
Kawamura
K
K
Takanashi
Y
Y
Komatsu
H
H
D002314:Cardioplegic Solutions / Q000008:administration & dosage*; D001026:Coronary Artery Bypass; D005260:Female; D005947:Glucose / Q000008:administration & dosage; D006801:Humans; D007328:Insulin / Q000008:administration & dosage; D008278:Magnesium Sulfate / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D015428:Myocardial Reperfusion Injury / Q000517:prevention & control; D009388:Neostigmine / Q000008:administration & dosage; D011188:Potassium / Q000008:administration & dosage; D019357:Potassium Citrate / Q000008:administration & dosage
D002314:Cardioplegic Solutions; D007328:Insulin; C042312:Young's cardioplegic solution; C030396:glucose-insulin-potassium cardioplegic solution; D009388:Neostigmine; D008278:Magnesium Sulfate; D019357:Potassium Citrate; D005947:Glucose; D011188:Potassium