title: Propofol infusion vs thiopentone/isoflurane anaesthesia for prominent ear correction in children.
abstract: Postoperative nausea and vomiting (PONV) frequently follows prominent ear correction under general anaesthesia in children. In a prospective, single-blind study, we compared the incidence of PONV after propofol infusion anaesthesia with that following thiopentone induction and isoflurane maintenance in 30 children aged from four to 14 years randomly allocated to one of two groups. All the children were mechanically ventilated. Anaesthesia was supplemented in both groups with nitrous oxide and infiltration of the ears using a mixture of bupivacaine, adrenaline, and hyaluronidase. One child receiving propofol (group P) complained of nausea, compared with eight receiving thiopentone/ isoflurane, (group T) (P = 0.005), while three children in group P and ten in group T vomited before hospital discharge, (P = 0.01). Eight children in group P were considered to be fit for discharge on the day of surgery as against four in group T, (not significant). Only four out of twelve children receiving opioid analgesia vomited.
authors.affiliation: Sheffield Children's Hospital, Western Bank, UK.
authors.forename: W M
authors.initials: WM
authors.lastname: Woodward
authors.forename: I
authors.initials: I
authors.lastname: Barker
authors.forename: R E
authors.initials: RE
authors.lastname: John
authors.forename: J E
authors.initials: JE
authors.lastname: Peacock
mesh_terms: D000293:Adolescent; D000762:Anesthesia Recovery Period; D000768:Anesthesia, General; D019162:Anesthetics, Combined; D018685:Anesthetics, Inhalation; D018686:Anesthetics, Intravenous / Q000009:adverse effects; D002648:Child; D002675:Child, Preschool; D004431:Ear, External / Q000002:abnormalities / Q000601:surgery*; D006801:Humans; D007530:Isoflurane / Q000009:adverse effects; D009325:Nausea / Q000139:chemically induced; D010149:Postoperative Pain / Q000188:drug therapy; D015742:Propofol / Q000009:adverse effects; D011446:Prospective Studies; D016037:Single-Blind Method; D013874:Thiopental / Q000009:adverse effects; D014839:Vomiting / Q000139:chemically induced
chemical_list: D019162:Anesthetics, Combined; D018685:Anesthetics, Inhalation; D018686:Anesthetics, Intravenous; D007530:Isoflurane; D013874:Thiopental; D015742:Propofol