Treatment, outcome and predictors of response in elderly depressed in-patients.
BACKGROUND
Full recovery rates in naturalistic studies of the treatment of elderly depressives are invariably lower than in clinical trials. This may be the result of inadequate treatment due to lack of clear treatment strategy recommendations for the elderly.


METHODS
This is a naturalistic prospective study of depressed elderly in-patients in three Dutch psychiatric hospitals. Patients were included when they suffered from any mood disorder according to DSM-III-R criteria. Severity of the depression was measured on the Montgomery-Asberg Rating Scale.


RESULTS
Antidepressants were prescribed to more than 90% of the patients. More than half of them received only one treatment. The dose of the antidepressants was less than the recommended dose for adults in 55% of cases. Full recovery from the depressive episode was achieved in less than half of the patients (33-45%).


CONCLUSIONS
In the present study a relatively poor outcome of the antidepressant treatment of elderly depressives has been found. A combination of low treatment expectations and fear of vigorous treatment seems to have been important.
Heeren
T J
TJ
University Hospital of Utrecht, The Netherlands.
Derksen
P
P
van Heycop Ten Ham
B F
BF
van Gent
P P
PP
D000368:Aged; D000369:Aged, 80 and over; D000928:Antidepressive Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D003866:Depressive Disorder / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D005260:Female; D006760:Hospitalization; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D016896:Treatment Outcome
D000928:Antidepressive Agents; D004338:Drug Combinations