[Morphological reversion of tumor cells by histone deacetylase inhibitors and radicicol].
Trichostatins and trapoxins, structurally unrelated microbial metabolites, are specific inhibitors of histone deacetylases. Radicicol inhibits Src family protein-tyrosine kinases. Recently, these agents were found to induce morphological reversion and enhanced expression of gelsolin, an actin regulatory protein, in a variety of transformed cells. Microinjection of an anti-gelsolin antibody that neutralizes the gelsolin function caused inhibition of the morphological change, suggesting that gelsolin expression is associated with the suppression of transformation.
Yoshida
M
M
Dept. of Biotechnology, Graduate School of Agriculture and Life Sciences, Tokyo University.
Honda
A
A
Horinouchi
S
S
D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D056572:Histone Deacetylase Inhibitors; D006801:Humans; D007783:Lactones / Q000494:pharmacology*; D018942:Macrolides; D051379:Mice; D009369:Neoplasms / Q000473:pathology*; D009374:Neoplasms, Experimental / Q000473:pathology; D011505:Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors; D014407:Tumor Cells, Cultured / Q000187:drug effects
D004791:Enzyme Inhibitors; D056572:Histone Deacetylase Inhibitors; D007783:Lactones; D018942:Macrolides; D011505:Protein-Tyrosine Kinases; C035359:monorden