Polypeptide growth factors: targeted delivery systems.
Growth factors are becoming extremely valuable tools in our attempts to understand the mechanisms that modulate cellular activities. Their targeting to appropriate cells and maintaining adequate pharmacological levels becomes essential, particularly in view of the different effects that these compounds have on various cells and the dose dependence of their response. Within this context, this review focuses primarily on the delivery of growth factors involved in the processes of wound healing and tissue repair.
Nimni
M E
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Department of Biochemistry & Molecular Biology, University of Southern California School of Medicine/Childrens Hospital Los Angeles, 90027, USA.
D000818:Animals; D001672:Biocompatible Materials; D001698:Biomedical Engineering; D019485:Bone Morphogenetic Proteins / Q000008:administration & dosage; D017439:Cicatrix, Hypertrophic / Q000188:drug therapy; D016503:Drug Delivery Systems; D004815:Epidermal Growth Factor / Q000008:administration & dosage; D016222:Fibroblast Growth Factor 2 / Q000008:administration & dosage; D017102:Fracture Healing / Q000187:drug effects; D006133:Growth Substances / Q000008:administration & dosage*; D006801:Humans; D007627:Keloid / Q000188:drug therapy; D009414:Nerve Growth Factors / Q000008:administration & dosage; D010455:Peptides / Q000008:administration & dosage; D010982:Platelet-Derived Growth Factor / Q000008:administration & dosage; D016212:Transforming Growth Factor beta / Q000008:administration & dosage / Q000502:physiology; D014945:Wound Healing / Q000187:drug effects
D001672:Biocompatible Materials; D019485:Bone Morphogenetic Proteins; D006133:Growth Substances; D009414:Nerve Growth Factors; D010455:Peptides; D010982:Platelet-Derived Growth Factor; D016212:Transforming Growth Factor beta; D016222:Fibroblast Growth Factor 2; D004815:Epidermal Growth Factor