Hypertension, aging, and atherosclerosis. The endothelial interface.
Hypertension, atherosclerosis, and aging are considered major independent risk factors for cardiovascular morbidity and mortality. Although independent as risk factors, the three entities are closely related and often operate simultaneously to affect the cardiovascular system adversely, resulting in damage to various organs. This article evaluates the evidence that endothelial damage may be the underlying pathophysiologic mechanism that connects the three entities.
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Laboratory on Hypertensive Disease, Alton Ochsner Medical Foundation, New Orleans, Louisiana, USA.
D000375:Aging / Q000502:physiology*; D000818:Animals; D001161:Arteriosclerosis / Q000150:complications / Q000503:physiopathology*; D001794:Blood Pressure / Q000187:drug effects; D002318:Cardiovascular Diseases / Q000209:etiology* / Q000401:mortality; D004730:Endothelium, Vascular / Q000502:physiology*; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000503:physiopathology*; D009569:Nitric Oxide / Q000096:biosynthesis / Q000378:metabolism / Q000502:physiology*
D009569:Nitric Oxide