title: Comparison of extradural and general anaesthesia on the fibrinolytic response to total knee arthroplasty.
abstract: Extradural anaesthesia is associated with lower incidences of deep vein thrombosis after total knee arthroplasty. It is not known if the type of anaesthesia influences thrombogenesis or fibrinolysis during knee surgery performed under tourniquet. We studied 31 patients allocated randomly to receive either extradural or general anaesthesia for primary unilateral total knee arthroplasty performed under tourniquet. Radial artery blood samples were obtained before surgery, during surgery with the tourniquet inflated and on deflation of the tourniquet. Plasma samples were assayed for markers of thrombin generation and fibrinolysis. Two of the circulating indices of thrombin generation, fibrinopeptide A and thrombin-antithrombin complexes, increased to a similar degree in the perioperative period in both groups. Fibrinolytic activity was similar in both groups, as measured by tissue plasminogen activator (t-PA) antigen, t-PA activity, t-PA-plasminogen activator inhibitor complexes, alpha 2-plasmin inhibitor-plasmin complexes and D-dimer. Extradural and general anaesthesia did not result in significant differences in either thrombin generation or fibrinolytic activity during total knee arthroplasty performed under tourniquet.
authors.affiliation: Department of Anaesthesiology, Hospital for Special Surgery, Cornell University Medical College, New York, USA.
authors.forename: N E
authors.initials: NE
authors.lastname: Sharrock
authors.forename: G
authors.initials: G
authors.lastname: Go
authors.forename: P
authors.initials: P
authors.lastname: Williams-Russo
authors.forename: S B
authors.initials: SB
authors.lastname: Haas
authors.forename: P C
authors.initials: PC
authors.lastname: Harpel
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000767:Anesthesia, Epidural; D000768:Anesthesia, General; D018681:Anesthetics, General / Q000494:pharmacology; D000779:Anesthetics, Local / Q000494:pharmacology; D000990:Antithrombin III / Q000378:metabolism; D005260:Female; D005342:Fibrinolysis / Q000187:drug effects*; D005344:Fibrinopeptide A / Q000378:metabolism; D006801:Humans; D007720:Knee Prosthesis; D008297:Male; D008875:Middle Aged; D010447:Peptide Hydrolases / Q000378:metabolism
chemical_list: D018681:Anesthetics, General; D000779:Anesthetics, Local; C046193:antithrombin III-protease complex; D005344:Fibrinopeptide A; D000990:Antithrombin III; D010447:Peptide Hydrolases