title: [Nedocromil sodium 1% nasal spray in the treatment of allergic rhinitis caused by Dermatophagoides pteronyssinus].
abstract: We have evaluated the efficacy of Nedocromil sodium 1% nasal solution in 36 patients (20 females and 16 males, mean age 29.5 years) suffering from perennial allergic rhinitis caused by Dermatophagoides pteronyssinus. Nedocromil sodium was given four times a day for 2 months. On a daily card patients had to report the severity of the considered symptoms (runny, nose, sneezing, itchy nose and stuffy nose) following an arbitrary score from 0 to 3 (0 = no symptom, 1 = mild, 2 = moderate, 3 = severe). Clinical evaluation was performed after 1 month and at the end of the treatment. We observed a statistically significant decrease of the considered symptoms already after a one month therapy. This improvement was higher after two months (p < 0.001). No side effects have been reported and no concomitant symptomatic therapy was needed. Nedocromil sodium is therefore a safe and efficacious drug in the treatment of allergic rhinitis caused by Dermatophagoides pteronyssinus.
authors.affiliation: Università, Policlinico Borgo Roma, Verona.
authors.forename: M L
authors.initials: ML
authors.lastname: Pacor
authors.forename: D
authors.initials: D
authors.lastname: Biasi
authors.forename: T
authors.initials: T
authors.lastname: Maleknia
authors.forename: A
authors.initials: A
authors.lastname: Carletto
authors.forename: C
authors.initials: C
authors.lastname: Lunardi
mesh_terms: D000328:Adult; D000818:Animals; D018926:Anti-Allergic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008925:Mites; D017835:Nedocromil / Q000008:administration & dosage / Q000627:therapeutic use*; D012221:Rhinitis, Allergic, Perennial / Q000188:drug therapy* / Q000209:etiology; D013997:Time Factors
chemical_list: D018926:Anti-Allergic Agents; D017835:Nedocromil