title: Long-term effects of intrauterine growth retardation.
abstract: Intrauterine growth retardation (IUGR) was studied both after experimental induction in rats and spontaneously occurring in man. The growth-retarded rat pups were compared to appropriately grown litter mates with developmental and behavioural tests at 50 and 90 days of age. Female rats exhibited no differences between growth-retarded and control rats but growth-retarded male rats had poor performance at 50 but not at 90 days compared to male controls. In the patient study 25 growth-retarded babies were compared with 21 appropriately grown controls. The growth-retarded babies had delayed latency periods of the visual evoked potentials at term and 6 weeks later, and at follow-up (18 months) demonstrated significantly more developmental and behavioural problems than the control group.
authors.affiliation: Department of Paediatrics, University of Göteborg, Sweden.
authors.forename: I
authors.initials: I
authors.lastname: Kjellmer
authors.forename: M
authors.initials: M
authors.lastname: Liedholm
authors.forename: B
authors.initials: B
authors.lastname: Sultan
authors.forename: M
authors.initials: M
authors.lastname: Wennergren
authors.forename: C
authors.initials: C
authors.lastname: Wallin Götborg
authors.forename: M
authors.initials: M
authors.lastname: Thordstein
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D002658:Developmental Disabilities / Q000209:etiology; D005074:Evoked Potentials, Visual; D005260:Female; D005317:Fetal Growth Retardation / Q000150:complications*; D006801:Humans; D007231:Infant, Newborn / Q000502:physiology* / Q000523:psychology; D007236:Infant, Small for Gestational Age / Q000502:physiology* / Q000523:psychology; D008297:Male; D051381:Rats; D012737:Sex Factors