Modification of hypothalamic-pituitary-adrenocortical activity by serotonergic agents in the rat.
The effects of tandospirone, enciprazine, gepirone, buspirone (5-HT1A agents) and carvotroline (5-HT2) on hypothalamic-pituitary-adrenocortical activity (HPA) activity were studied. These drugs increased the plasma corticosterone levels in a dose-dependent manner. Their ED50 values were 3.8, 31.8, 3.1, 3.4 and 7.0 mg/kg, respectively. Drug effects peaked between 30 min and 1 h, and plasma corticosterone levels returned to control levels after 2 h. When the drugs were given in conjunction with a rotatory stress, gepirone and enciprazine increased and carvotroline decreased plasma corticosterone levels. Dexamethasone (0.1 mg/kg) pretreatment reduced drug-activated HPA axis activity.
Matheson
G K
GK
Neurobiology Laboratory, Indiana University, School of Medicine, Evansville 44712, USA. Matheson@indyvax.iupui.edu
Knowles
A
A
Gage
D
D
Michel
C
C
Guthrie
D
D
Bauer
C
C
Blackbourne
J
J
Weinzapfel
D
D
D000302:Adrenal Cortex / Q000187:drug effects* / Q000502:physiology; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D002065:Buspirone / Q000494:pharmacology; D002243:Carbolines / Q000494:pharmacology; D003345:Corticosterone / Q000097:blood; D004305:Dose-Response Relationship, Drug; D054833:Isoindoles; D008297:Male; D010879:Piperazines / Q000494:pharmacology; D010902:Pituitary Gland / Q000187:drug effects* / Q000502:physiology; D011725:Pyridines / Q000494:pharmacology; D011743:Pyrimidines / Q000494:pharmacology; D051381:Rats; D017366:Serotonin Receptor Agonists / Q000494:pharmacology*
D002243:Carbolines; D054833:Isoindoles; D010879:Piperazines; D011725:Pyridines; D011743:Pyrimidines; D017366:Serotonin Receptor Agonists; C055267:tandospirone; C109547:carvotroline; C039979:gepirone; C057238:enciprazine; D002065:Buspirone; D003345:Corticosterone