title: Two cases of hypergranular acute lymphoblastic leukemia.
abstract: Two patients with hypergranular acute lymphoblastic leukemia are presented: they represent 1.4% of patients with acute lymphoblastic leukemia studied and treated in a single institution in the past 12 years. This frequency is substantially lower than that reported in Caucasian populations. The blast cells of the patients disclosed an early-B phenotype, displaying CD45, CD10 and CD19 antigens. The cytoplasmic granules were positive for the PAS reaction. Both patients died early after starting treatment; a poor prognosis has been recorded previously for patients with this type of malignancy.
authors.affiliation: Laboratorios Clínicos de Puebla, México.
authors.forename: E
authors.initials: E
authors.lastname: Bolado-Martínez
authors.forename: M
authors.initials: M
authors.lastname: Vivanco-Jiménez
authors.forename: F
authors.initials: F
authors.lastname: García-Ramírez
authors.forename: G
authors.initials: G
authors.lastname: Ruiz-Reyes
authors.forename: A
authors.initials: A
authors.lastname: Ruiz-Argüelles
authors.forename: G J
authors.initials: GJ
authors.lastname: Ruiz-Argüelles
mesh_terms: D000328:Adult; D000951:Antigens, Neoplasm / Q000032:analysis; D002051:Burkitt Lymphoma / Q000145:classification / Q000453:epidemiology / Q000473:pathology*; D003594:Cytoplasmic Granules / Q000737:chemistry*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D008297:Male; D008875:Middle Aged; D014411:Neoplastic Stem Cells / Q000648:ultrastructure*; D015260:Neprilysin / Q000032:analysis; D010503:Periodic Acid-Schiff Reaction; D011379:Prognosis
chemical_list: D000951:Antigens, Neoplasm; D015260:Neprilysin