title: Prospective seroepidemiological study of role of human papillomavirus in non-cervical anogenital cancers.
abstract: OBJECTIVE
  To evaluate the association between infection with the major oncogenic types of human papillomavirus and the risk of developing non-cervical anogenital cancers in a cohort followed up prospectively.
  
  
  METHODS
  Data from two large serum banks to which about 700,000 people had donated serum samples were followed up for a mean of 8 years. People who developed non-cervical anogenital cancers during follow up were identified by registry linkage with the nationwide cancer registries in Finland and Norway. Within this cohort a nested case-control study was conducted based on the serological diagnosis of infection with human papillomavirus types 16, 18, and 33.
  
  
  METHODS
  81 cases and 240 controls matched for sex, age, and storage time of serum samples.
  
  
  METHODS
  Odds ratios of developing non-cervical anogenital cancers in presence of IgG antibodies to specific micro-organisms.
  
  
  RESULTS
  Subjects seropositive for human papillomavirus type 16 had an increased risk of developing non-cervical anogenital cancers (odds ratio 3.1 (95% confidence interval 1.4 to 6.9)). Subjects seropositive for type 33 also had an increased risk (odds ratio 2.8 (1.0 to 8.3)) but not significantly after adjustment for infection with type 16. Seropositivity for human papillomavirus type 16 was associated with an increased risk of developing vulvar and vaginal cancers (odds ratio 4.5 (1.1 to 22)) and a strongly increased risk of developing preinvasive vulvar and vaginal lesions (odds ratio infinity (3.8 to infinity)). Seropositivity for human papillomavirus type 18 increased the risk of developing preinvasive lesions (odds ratio 12 (1.2 to 590)). High, but non-significant odds ratios for types 16 and 33 were seen for penile cancers.
  
  
  CONCLUSIONS
  This study provides prospective seroepidemiological evidence that infection with human papillomavirus type 16 confers an increased risk of developing non-cervical genital cancers, particularly vulvar and vaginal cancers.
authors.affiliation: Cancer Registry of Norway, Institute for Epidemiological Cancer Research, Montebello, Oslo, Norway. tb@kreftreg.no
authors.forename: T
authors.initials: T
authors.lastname: Bjørge
authors.forename: J
authors.initials: J
authors.lastname: Dillner
authors.forename: T
authors.initials: T
authors.lastname: Anttila
authors.forename: A
authors.initials: A
authors.lastname: Engeland
authors.forename: T
authors.initials: T
authors.lastname: Hakulinen
authors.forename: E
authors.initials: E
authors.lastname: Jellum
authors.forename: M
authors.initials: M
authors.lastname: Lehtinen
authors.forename: T
authors.initials: T
authors.lastname: Luostarinen
authors.forename: J
authors.initials: J
authors.lastname: Paavonen
authors.forename: E
authors.initials: E
authors.lastname: Pukkala
authors.forename: M
authors.initials: M
authors.lastname: Sapp
authors.forename: J
authors.initials: J
authors.lastname: Schiller
authors.forename: L
authors.initials: L
authors.lastname: Youngman
authors.forename: S
authors.initials: S
authors.lastname: Thoresen
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001005:Anus Neoplasms / Q000453:epidemiology / Q000821:virology*; D015331:Cohort Studies; D005260:Female; D005387:Finland / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009664:Norway / Q000453:epidemiology; D016017:Odds Ratio; D030361:Papillomavirus Infections / Q000150:complications* / Q000453:epidemiology; D011446:Prospective Studies; D012307:Risk Factors; D016036:Seroepidemiologic Studies; D014412:Tumor Virus Infections / Q000150:complications* / Q000453:epidemiology; D014571:Urologic Neoplasms / Q000453:epidemiology / Q000821:virology*; D014625:Vaginal Neoplasms / Q000453:epidemiology / Q000821:virology; D014846:Vulvar Neoplasms / Q000453:epidemiology / Q000821:virology