title: Chondrosarcoma as a complicating factor in Paget's disease of bone.
abstract: A 65-year-old male patient with an 8-year history of poliostotic Paget's disease complained of shoulder pain that started 6 months prior to admission. An extensive lytic area was identified in the right proximal humerus along with Paget's disease. There was cortical destruction and a soft tissue mass. Following an incisional biopsy, a diagnosis of grade 2 chondrosarcoma associated with Paget's disease was made. The histologic identification of chondrosarcoma associated with Paget's disease is rare. However, the presence of a calcified matrix in a destructive lesion associated with Paget's disease should alert the radiologist and the pathologist to the possibility of a chondromatous differentiation taking place in the sarcoma associated with Paget's disease. The histologic evaluation of the lesion will form the basis for the diagnosis.
authors.affiliation: Department of Orthopedics Rizzoli Orthopedic Institute, Bologna, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Brandolini
authors.forename: P
authors.initials: P
authors.lastname: Bacchini
authors.forename: M
authors.initials: M
authors.lastname: Moscato
authors.forename: F
authors.initials: F
authors.lastname: Bertoni
mesh_terms: D000368:Aged; D001859:Bone Neoplasms / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D002813:Chondrosarcoma / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D008297:Male; D010001:Osteitis Deformans / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D011859:Radiography