Non-immunosuppressive cyclosporine derivative PSC 833 abolishes resistance of human multidrug-resistant ovarian carcinoma cells in vitro to paclitaxel and paclitaxel-induced radiosensitization.
Chorvath
B
B
Sedlak
J
J
Novotny
L
L
Hunakova
L
L
Boljesikova
E
E
Sevcikova
L
L
Chorvath
M
M
D002277:Carcinoma / Q000378:metabolism*; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D003524:Cyclosporins / Q000008:administration & dosage / Q000494:pharmacology*; D018432:Drug Resistance, Multiple; D019008:Drug Resistance, Neoplasm; D005260:Female; D006801:Humans; D010051:Ovarian Neoplasms / Q000378:metabolism*; D017239:Paclitaxel / Q000494:pharmacology*; D011838:Radiation-Sensitizing Agents; D014407:Tumor Cells, Cultured / Q000187:drug effects
D003524:Cyclosporins; D011838:Radiation-Sensitizing Agents; D017239:Paclitaxel; C070272:valspodar