N1-Hetaryl substituted pyridine- and pyrazinecarboxamidrazones with antimycobacterial activity.
A series of amidrazones was prepared and characterized by 1H NMR and mass spectroscopy. The substances were tested against M. tuberculosis, M. avium, M. intracellulare, and M. lufu. Compounds 11-13 exhibit a satisfactory inhibition of mycobacteria.
Ranft
D
D
Institut für Pharmazeutische Chemie, Halle.
Lehwark-Yvetot
G
G
Schaper
K J
KJ
Büge
A
A
D000995:Antitubercular Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D009161:Mycobacterium / Q000187:drug effects* / Q000254:growth & development; D009162:Mycobacterium avium / Q000187:drug effects; D015269:Mycobacterium avium Complex / Q000187:drug effects; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D011719:Pyrazines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship
D000995:Antitubercular Agents; D011719:Pyrazines; D011725:Pyridines