Genomic diversity in the pfoA region of the theta-toxin-deficient strains of Clostridium perfringens.
The genomic structure of the pfoA-colA region in six theta-toxin-deficient strains of Clostridium perfringens was examined by Southern hybridization using the pfoR, pfoA, pbg, arcABDC and colA genes, encoding regulator for pfoA, theta-toxin, beta-galactosidase, arginine metabolism enzymes and kappa-toxin, respectively, as gene probes. It is suggested that the productivity of theta-toxin in these strains is diverse because of the multiple genetic backgrounds including single deletion of pfoA, large deletion of the pfoA-colA region and the putative point mutations.
Ba-Thein
W
W
Department of Microbiology, University of Tsukuba, Ibaraki, Japan.
Inui
S
S
Shimizu
T
T
Swe
T
T
Banu
S
S
Ohtani
K
K
Oe
M
M
Sakurai
N
N
Nakamura
S
S
Hayashi
H
H
D001427:Bacterial Toxins / Q000235:genetics*; D003016:Clostridium perfringens / Q000235:genetics*; D014644:Genetic Variation
D001427:Bacterial Toxins