title: Hemin induces germ tube formation in Candida albicans.
abstract: Hemin induced germination of Candida albicans blastoconidia when cells grown up to the early exponential phase were shifted from 28 to 37 degrees C (70 to 75% of cells exhibited germ tubes). N-Acetyl-D-glucosamine (GlcNAc), another inducer of myceliation in this fungus, caused a similar effect. The combination of hemin and GlcNAc resulted in a higher percentage (95%) of blastoconidial germination. These results suggest that in addition to temperature, hemin levels and carbon source may coordinately regulate the expression of subsets of genes involved in the yeast-to-mycelium transition in C. albicans.
authors.affiliation: Departamento de Microbiogía y Ecología, Facultad de Farmacia, Universitat de València, Burjasot, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Casanova
authors.forename: A M
authors.initials: AM
authors.lastname: Cervera
authors.forename: D
authors.initials: D
authors.lastname: Gozalbo
authors.forename: J P
authors.initials: JP
authors.lastname: Martínez
mesh_terms: D000117:Acetylglucosamine / Q000494:pharmacology*; D002176:Candida albicans / Q000166:cytology / Q000187:drug effects* / Q000254:growth & development; D002454:Cell Differentiation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D005947:Glucose / Q000494:pharmacology; D006427:Hemin / Q000494:pharmacology*; D013172:Spores, Fungal / Q000166:cytology / Q000187:drug effects / Q000254:growth & development
chemical_list: D006427:Hemin; D005947:Glucose; D000117:Acetylglucosamine