Immunohistochemical study of acinic cell carcinoma of minor salivary gland.
Acinic cell carcinoma (ACC) is a rare salivary gland tumour, making up 4% of all minor salivary gland tumors. Typically, it is composed of acinic cells although transitional and duct-like cells are also identified. In the present study, a panel of antibodies was applied to eight minor salivary gland ACCs. Antibodies tested were: cytokeratins 7, 8, 13, 14, 18, 19, vimentin and actin (HHF35). Immunohistochemical staining revealed that cytokeratin 8, among the tested antibodies, was the more specific to neoplastic cells with a pattern of distribution quite variable and peculiar. This staining may be useful in the recognition of neoplastic acinic cells.
Crivelini
M M
MM
Paulista State University, Araçatuba, Brazil.
de Sousa
S O
SO
de Araújo
V C
VC
D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis*; D018267:Carcinoma, Acinar Cell / Q000737:chemistry*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007633:Keratins / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D012468:Salivary Gland Neoplasms / Q000737:chemistry*; D012470:Salivary Glands, Minor
D014408:Biomarkers, Tumor; D007633:Keratins