Malignant and corticosteroid-dependent idiopathic anaphylaxis: successful responses to ketotifen.
BACKGROUND
Malignant idiopathic anaphylaxis refers to the most severe form of idiopathic anaphylaxis where defined episodes of idiopathic anaphylaxis are not controlled when the prednisone is reduced below at least 60 mg every other day or 20 mg daily. Corticosteroid-dependent idiopathic anaphylaxis refers to patients with idiopathic anaphylaxis who require continuous daily or alternate day prednisone at threshold doses for control of idiopathic anaphylaxis. Ketotifen has been reported to help induce remission in some patients with idiopathic anaphylaxis and has steroid sparing effects in other patients with idiopathic anaphylaxis.


METHODS
We present five patients, two with malignant idiopathic anaphylaxis and three with corticosteroid-dependent idiopathic anaphylaxis, who responded to the administration of ketotifen.


RESULTS
All five patients, while receiving ketotifen, had a reduction or resolution of their episodes of idiopathic anaphylaxis and prednisone was tapered and discontinued.


CONCLUSIONS
Ketotifen is shown to be successful in inducing remission in two patients with malignant idiopathic anaphylaxis and in three additional patients with corticosteroid-dependent idiopathic anaphylaxis. An additional patient with malignant idiopathic anaphylaxis had prednisone stopped after elective hip surgery.
Patterson
R
R
Ernest S. Bazley Asthma and Allergic Diseases Center of the Department of Medicine of Northwestern Memorial Hospital and Northwestern University Medical School, Chicago, Illinois 60611, USA.
Fitzsimons
E J
EJ
Choy
A C
AC
Harris
K E
KE
D000305:Adrenal Cortex Hormones / Q000494:pharmacology*; D000328:Adult; D000707:Anaphylaxis / Q000209:etiology* / Q000517:prevention & control; D018926:Anti-Allergic Agents / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007665:Ketotifen / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D011241:Prednisone / Q000008:administration & dosage / Q000627:therapeutic use
D000305:Adrenal Cortex Hormones; D018926:Anti-Allergic Agents; D011241:Prednisone; D007665:Ketotifen