title: Elevated plasma bile acids in hypergalactosaemic neonates: a diagnostic clue to portosystemic shunts.
abstract: To determine whether plasma levels of total bile acids may provide a useful index for hypergalactosaemia due to porto-systemic shunts, these levels were determined in hypergalactosaemic neonates. Increased levels were found in all cases with portohepatic venous or portocaval shunts. The levels of both total bile acids and galactose were normalized when the shunts disappeared on the echograms. Both bile acids and galactose are almost completely absorbed by the liver via the first portal blood passage. Portosystemic shunts contribute to elevated levels of bile acids and galactose.
  
  
  CONCLUSIONS
  Increased plasma levels of total bile acids serve as a diagnostic clue to the presence of portosystemic shunts in neonates with hypergalactosaemia.
authors.affiliation: Department of Paediatrics, Hiroshima University School of Medicine, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Sakura
authors.forename: N
authors.initials: N
authors.lastname: Mizoguchi
authors.forename: T
authors.initials: T
authors.lastname: Eguchi
authors.forename: H
authors.initials: H
authors.lastname: Ono
authors.forename: H
authors.initials: H
authors.lastname: Mawatari
authors.forename: K
authors.initials: K
authors.lastname: Naitou
authors.forename: K
authors.initials: K
authors.lastname: Ito
mesh_terms: D001165:Arteriovenous Malformations / Q000097:blood / Q000150:complications*; D001647:Bile Acids and Salts / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D003937:Diagnosis, Differential; D005260:Female; D005693:Galactosemias / Q000097:blood / Q000209:etiology*; D006503:Hepatic Veins / Q000002:abnormalities*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D011169:Portal Vein / Q000002:abnormalities*; D014682:Vena Cava, Inferior / Q000002:abnormalities*
chemical_list: D001647:Bile Acids and Salts