Altered Ca(2+)-homeostasis in single T-lymphocytes of depressed patients.
After stimulation of T-lymphocytes from healthy volunteers with the mitogen phytohemagglutinin (PHA) 40% of the cells exhibit an oscillatory increase in intracellular calcium concentration ([Ca2+]i). During depression the number of cells responding to PHA is reduced to 20%. These cells show a marked decrease in [Ca2+]i-reaction to stimulation and flattened oscillations. This reduction of mitogen-induced Ca2+ signals in T-cells of depressed patients appears to be a reliable state marker in depressive illness and is reversed upon successful treatment with interpersonal psychotherapy (IPT).
Aldenhoff
J B
JB
Department of Psychiatry, Central Institute of Mental Health, Mannheim, Germany.
Dumais-Huber
C
C
Fritzsche
M
M
Sulger
J
J
Vollmayr
B
B
D000328:Adult; D002118:Calcium / Q000097:blood*; D015220:Calcium Channels / Q000502:physiology*; D003866:Depressive Disorder / Q000175:diagnosis / Q000276:immunology* / Q000628:therapy; D005260:Female; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D008213:Lymphocyte Activation / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D011613:Psychotherapy; D015398:Signal Transduction / Q000502:physiology; D013601:T-Lymphocytes / Q000276:immunology*; D016896:Treatment Outcome
D015220:Calcium Channels; D002118:Calcium