Unsuccessful treatment of missed abortion with a combination of an antiprogesterone and a prostaglandin E1 analogue.
In a prospective clinical trial the effectiveness of a combination of 400 mg of mifepristone (antiprogesterone) and 400 g misoprostol (synthetic prostaglandin E1 analogue), both taken orally, was evaluated for the treatment of missed abortion. Of the 31 patients included, 16 (52%) had an empty uterine cavity at follow up six days after inclusion, 11 (35%) required surgical evacuation for retained intrauterine products of conception found at follow up, and four (13%) required emergency surgical evacuation due to severe pain or bleeding. The results do not support the use of mifepristone and misoprostol for women wishing the miscarriage to be resolved quickly.
Nielsen
S
S
Department of Obstetrics and Gynaecology, Sahlgrenska University Hospital, Göteborg, Sweden.
Hahlin
M
M
Platz-Christensen
J J
JJ
D000020:Abortifacient Agents, Nonsteroidal / Q000008:administration & dosage*; D000021:Abortifacient Agents, Steroidal / Q000008:administration & dosage*; D000030:Abortion, Missed / Q000188:drug therapy*; D000284:Administration, Oral; D004338:Drug Combinations; D005260:Female; D006801:Humans; D015735:Mifepristone / Q000008:administration & dosage*; D016595:Misoprostol / Q000008:administration & dosage*; D011247:Pregnancy; D011446:Prospective Studies; D017211:Treatment Failure
D000020:Abortifacient Agents, Nonsteroidal; D000021:Abortifacient Agents, Steroidal; D004338:Drug Combinations; D016595:Misoprostol; D015735:Mifepristone