title: Apparent normal phenotype of Fgf6-/- mice.
abstract: To study the role of the sixth member of the FGF (fibroblast growth factor) family whose expression is restricted to skeletal muscle, we have derived mouse mutants with a homozygous disruption of the Fgf6 gene. The animals are viable, fertile and apparently normal, indicating that FGF6 is not required for vital functions in the laboratory mouse.
authors.affiliation: Laboratoire d'Oncologie Moléculaire, U119 INSERM, Marseille, France.
authors.forename: F
authors.initials: F
authors.lastname: Fiore
authors.forename: J
authors.initials: J
authors.lastname: Planche
authors.forename: P
authors.initials: P
authors.lastname: Gibier
authors.forename: A
authors.initials: A
authors.lastname: Sebille
authors.forename: O
authors.initials: O
authors.lastname: deLapeyrière
authors.forename: D
authors.initials: D
authors.lastname: Birnbaum
mesh_terms: D000818:Animals; D001755:Blastocyst / Q000378:metabolism; D015139:Blotting, Southern; D005314:Embryonic and Fetal Development; D005260:Female; D051522:Fibroblast Growth Factor 6; D005346:Fibroblast Growth Factors; D018390:Gene Targeting / Q000379:methods; D005822:Genetic Vectors; D005838:Genotype; D006720:Homozygote; D007763:Lac Operon / Q000235:genetics; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D018482:Muscle, Skeletal / Q000196:embryology / Q000502:physiology*; D010641:Phenotype; D016133:Polymerase Chain Reaction; D011518:Proto-Oncogene Proteins / Q000172:deficiency / Q000235:genetics* / Q000502:physiology; D011995:Recombination, Genetic; D013234:Stem Cells / Q000378:metabolism; D014162:Transfection
chemical_list: C486115:Fgf6 protein, mouse; D051522:Fibroblast Growth Factor 6; D011518:Proto-Oncogene Proteins; D005346:Fibroblast Growth Factors