title: Mucosal interleukin-1 beta production and acid secretion in enlarged fold gastritis.
abstract: BACKGROUND
  We have previously shown that eradication of Helicobacter pylori increases acid secretion in H. pylori-associated enlarged fold gastritis.
  
  
  OBJECTIVE
  To investigate whether locally produced interleukin-1 beta is possibly involved in the inhibition of acid secretion in H. pylori gastritis.
  
  
  METHODS
  IL-1 beta release from the gastric body mucosa was determined by short-term culture of biopsy specimens in 13 patients with enlarged fold gastritis (all H. pylori-positive), five H. pylori-positive and 10 H. pylori-negative patients without enlarged folds. The acid-inhibitory effect of locally produced IL-1 beta was examined by [14C]-aminopyrine uptake assay using isolated rabbit gastric glands.
  
  
  RESULTS
  IL-1 beta release was significantly greater in patients with enlarged fold gastritis, significantly correlated with both basal and tetragastrin-stimulated acid outputs in the H. pylori-positive patients (r = -0.591 and r = -0.641, respectively; P < 0.01), and significantly decreased with concomitant increases in acid secretions after eradication of H. pylori. [14C]-aminopyrine uptake was inhibited by IL-1 beta in a dose-dependent manner.
  
  
  CONCLUSIONS
  Increased production of IL-1 beta caused by H. pylori infection is possibly involved in the inhibition of acid secretion in enlarged fold gastritis.
authors.affiliation: Second Department of Internal Medicine, Osaka University Medical School, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Yasunaga
authors.forename: Y
authors.initials: Y
authors.lastname: Shinomura
authors.forename: S
authors.initials: S
authors.lastname: Kanayama
authors.forename: Y
authors.initials: Y
authors.lastname: Higashimoto
authors.forename: M
authors.initials: M
authors.lastname: Yabu
authors.forename: Y
authors.initials: Y
authors.lastname: Miyazaki
authors.forename: Y
authors.initials: Y
authors.lastname: Murayama
authors.forename: H
authors.initials: H
authors.lastname: Nishibayashi
authors.forename: S
authors.initials: S
authors.lastname: Kitamura
authors.forename: Y
authors.initials: Y
authors.lastname: Matsuzawa
mesh_terms: D000328:Adult; D000368:Aged; D000632:Aminopyrine / Q000378:metabolism; D000818:Animals; D005260:Female; D005744:Gastric Acid / Q000378:metabolism*; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism*; D005755:Gastrins / Q000097:blood; D005758:Gastritis, Hypertrophic / Q000378:metabolism* / Q000473:pathology; D016481:Helicobacter Infections / Q000378:metabolism*; D016480:Helicobacter pylori; D006801:Humans; D007375:Interleukin-1 / Q000096:biosynthesis* / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D011817:Rabbits; D013270:Stomach / Q000473:pathology
chemical_list: D005755:Gastrins; D007375:Interleukin-1; D000632:Aminopyrine