title: MIN 14C UBT: a combination of gastric basal transit and 14C-urea breath test for the detection of Helicobacter pylori infection in human beings.
abstract: The purpose of this work is to demonstrate that the 14C-urea breath test (UBT) performed at different times combined with the study of the gastric basal transit, which evaluates the intragastric displacement of a labeled solution under fasting conditions, has the advantage of being representative of the whole stomach surface and constitutes a non-aggressive test for the detection of H. pylori. This test, which has been called MIN 14C UBT, is a modification of the conventional 14C UBT in which low volumes of a solution of 14C-urea together with 99mTc-sulfur colloid are administered. The 99mTc-sulfur colloid is not absorbed in the gastrointestinal tract and has the great advantage of allowing the "visualization" of the transit of the 14C-urea within the gastrointestinal tract. This modification allows the simultaneous determination of the production of the 14CO2 and the place where this process occurs. The results show that there is a good correlation between the images obtained and the breath samples collected. We found that this test has a sensitivity of 98% and a specificity of 96% for H. pylori detection.
authors.affiliation: Radioisotope Laboratory, Facultad de Farmacia y Bioquímica, University of Buenos Aires, Argentina.
authors.forename: M
authors.initials: M
authors.lastname: Zubillaga
authors.forename: P
authors.initials: P
authors.lastname: Oliveri
authors.forename: M L
authors.initials: ML
authors.lastname: Calcagno
authors.forename: C
authors.initials: C
authors.lastname: Goldman
authors.forename: R
authors.initials: R
authors.lastname: Caro
authors.forename: A
authors.initials: A
authors.lastname: Mitta
authors.forename: O
authors.initials: O
authors.lastname: Degrossi
authors.forename: J
authors.initials: J
authors.lastname: Boccio
mesh_terms: D001944:Breath Tests; D002245:Carbon Dioxide / Q000378:metabolism; D002250:Carbon Radioisotopes; D005260:Female; D016481:Helicobacter Infections / Q000175:diagnosis*; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D013270:Stomach / Q000503:physiopathology*; D014508:Urea / Q000378:metabolism*
chemical_list: D002250:Carbon Radioisotopes; D002245:Carbon Dioxide; D014508:Urea