Expression of P-glycoprotein 170 in nasal mucosa may be increased with topical steroids.
The synthesis of P-glycoprotein 170 (P-gp), a "multidrug resistance" protein capable of extruding various drugs including 11-OH steroids from human cells, can be upregulated by certain glucocorticosteroids. This study demonstrates the presence of P-gp in the columnar surface epithelium and in glandular acini of healthy nasal mucosa with immunohistochemical technique. Furthermore, nasal polyps from 5 of 17 patients treated with clinical doses of a topical nasal steroid, budesonide, appear to show a stronger staining intensity for P-gp than polyps from 13 untreated patients. This suggests the possibility of local P-gp gene induction by topical glucocorticoid treatment. Upregulation of P-gp synthesis appears as a new possible cause of relative resistance to topical steroid medication in patients with nasal inflammatory disease.
Henriksson
G
G
Department of Otorhinolaryngology, Huddinge University Hospital, Sweden.
Norlander
T
T
Zheng
X
X
Stierna
P
P
Westrin
K M
KM
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000276:immunology / Q000378:metabolism*; D000287:Administration, Topical; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D001706:Biopsy; D019819:Budesonide; D004848:Epithelium / Q000378:metabolism; D005938:Glucocorticoids; D006801:Humans; D007150:Immunohistochemistry; D009297:Nasal Mucosa / Q000187:drug effects* / Q000378:metabolism*; D009298:Nasal Polyps / Q000378:metabolism*; D011282:Pregnenediones / Q000494:pharmacology*
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D000893:Anti-Inflammatory Agents; D005938:Glucocorticoids; D011282:Pregnenediones; D019819:Budesonide