[The clinical importance of determining protein C and protein S in patients with nonspecific aortoarteritis].
Solid-phase enzyme immunoassay estimated S and C protein levels in 10 patients with nonspecific aortic arteritis (NAA). Lowered concentrations of total protein S (< 70%) occurred in 8 (80%) of 10 NAA patients, in 3 of them protein C was also low. Isolated reduction of protein C was encountered only in one patient. Four patients (44%) of 9 had antibodies to phospholipids, as a rule, in low concentrations. 3 of them had low total protein S concentrations against normal C protein. 4 patients (40%) showed elevated concentrations of WF antigen concentrations. No relationship was noted between a fall in total protein S, C concentrations and clinical presentation of NAA, the disease activity, presence of antibodies to neutrophil cytoplasm and antibodies to endothelial cells. Thus, a reduction in the levels of total protein S in NAA patients is induced by endothelial dysfunction unrelated to production of antibodies to phospholipids, neutrophil cytoplasm and vascular endothelium.
Baranov
A A
AA
Nasonov
E L
EL
Shilkina
N P
NP
Salozhin
K V
KV
Nikolaev
A G
AG
Prokopenko
A V
AV
Tishchenko
V A
VA
D000328:Adult; D017153:Antibodies, Anticardiolipin / Q000097:blood; D000936:Antigen-Antibody Complex / Q000097:blood; D001025:Aortitis / Q000097:blood* / Q000276:immunology; D001167:Arteritis / Q000097:blood* / Q000276:immunology; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000097:blood; D008297:Male; D011486:Protein C / Q000032:analysis*; D017293:Protein S / Q000032:analysis*; D014841:von Willebrand Factor / Q000032:analysis
D017153:Antibodies, Anticardiolipin; D000936:Antigen-Antibody Complex; D007136:Immunoglobulins; D011486:Protein C; D017293:Protein S; D014841:von Willebrand Factor