title: Longitudinal study of plasma cortisol and 17-hydroxyprogesterone in very-low-birth-weight infants during the first 16 weeks of life.
abstract: There are few published data on plasma cortisol and 17-hydroxyprogesterone (17-OHP) in very-low-birth-weight (VLBW) infants beyond the 1st week of life. We therefore measured plasma cortisol and 17-OHP longitudinally in 26 infants (median birth weight 930 g, median gestational age 28 weeks) from 1 to 16 postnatal weeks to document normative values. We also examined the effect of clinical state on plasma cortisol and 17-OHP levels. Median plasma cortisol decreased with postnatal age from 1 to 8 weeks (110 vs. 60 nmol/l; p = 0.0007) and with postconceptional age from 25 to 36 weeks (104 vs. 47 nmol/l; p = 0.002). Median plasma 17-OHP decreased with postnatal age from 1 to 16 weeks (17.0 vs. 7.1 nmol/l; p < 0.0005) and also with postconceptional age from 25 to 42 weeks (21.1 vs. 7.1 nmol/l; p < 0.0005). Plasma cortisol was not influenced by the clinical state. Median plasma 17-OHP was significantly higher for 'unwell' versus 'well' infants at 5-8 weeks postnatal age (23.0 vs. 12.5 nmol/l; p = 0.012) but not at other postnatal age intervals. These data provide information on adrenocortical function in VLBW infants during the first 4 months of life.
authors.affiliation: Department of Neonatology, Royal North Shore Hospital, St Leonards, Australia. jdarnold@blackburn.med.su.cz.au
authors.forename: J
authors.initials: J
authors.lastname: Arnold
authors.forename: G
authors.initials: G
authors.lastname: Leslie
authors.forename: J
authors.initials: J
authors.lastname: Bowen
authors.forename: S
authors.initials: S
authors.lastname: Watters
authors.forename: D
authors.initials: D
authors.lastname: Kreutzmann
authors.forename: M
authors.initials: M
authors.lastname: Silink
mesh_terms: D019326:17-alpha-Hydroxyprogesterone / Q000097:blood* / Q000378:metabolism; D000375:Aging / Q000097:blood; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood* / Q000378:metabolism; D007223:Infant; D007231:Infant, Newborn; D019102:Infant, Very Low Birth Weight / Q000097:blood* / Q000378:metabolism; D008137:Longitudinal Studies; D008297:Male
chemical_list: D019326:17-alpha-Hydroxyprogesterone; D006854:Hydrocortisone