title: A prospective study of olfaction following endoscopic sinus surgery with adjuvant medical treatment.
abstract: Few studies on the outcome of endoscopic sinus surgery have assessed the effect of this treatment on the sense of smell. We have collected data prospectively on 115 patients, before and 6 weeks after surgery. All patients had bilateral chronic rhinosinusitis. Visual analogue and a 4-grade, patient-rated symptom score related to olfaction was collected. Patients were also asked after surgery whether their sense of smell was normal, better, a little better, the same, a little worse or worse. Paired phenylethyl methyl ethyl carbinol olfactory detection thresholds were determined for 102 of the patients. All parameters showed a statistically significant improvement (P < 0.001). Acoustic rhinometry was performed pre- and postoperatively in 96 patients. The improvement in all olfactory symptom scores was found to correlate with the increase in nasal volume (Spearman rank correlation: visual analogue score, P < 0.005; 4-grade scale, P = 0.03; 'better, same, worse' scale, P = 0.001).
authors.affiliation: Department of ENT Surgery, Charing Cross Hospital, London, UK.
authors.forename: J M
authors.initials: JM
authors.lastname: Rowe-Jones
authors.forename: I S
authors.initials: IS
authors.lastname: Mackay
mesh_terms: D017024:Chemotherapy, Adjuvant; D002908:Chronic Disease; D004724:Endoscopy; D006801:Humans; D010256:Paranasal Sinuses / Q000601:surgery*; D011446:Prospective Studies; D012720:Severity of Illness Index; D012852:Sinusitis / Q000188:drug therapy* / Q000601:surgery*; D012903:Smell