Neokyotorphin and neokyotorphin (1-4): secretion by erythrocytes and regulation of tumor cell growth.
Human erythrocytes release neokyotorphin, the 137-141 fragment of hemoglobin alpha-chain into the supernatant of red blood cells primary culture. However, the neokyotorphin fragment 1-4 that is formed together with neokyotorphin inside the red blood cells and in various tissues is not found in the supernatant. Both neokyotorphin and its 1-4 fragment were shown to stimulate proliferation of L929 tumor cells.
Blishchenko
E Y
EY
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry Russian Academy of Sciences, Moscow.
Mernenko
O A
OA
Yatskin
O N
ON
Ziganshin
R H
RH
Philippova
M M
MM
Karelin
A A
AA
Ivanov
V T
VT
D002455:Cell Division / Q000187:drug effects*; D002851:Chromatography, High Pressure Liquid; D004723:Endorphins / Q000378:metabolism* / Q000494:pharmacology; D004912:Erythrocytes / Q000378:metabolism*; D006801:Humans; D010446:Peptide Fragments / Q000378:metabolism* / Q000494:pharmacology; D017421:Sequence Analysis; D014407:Tumor Cells, Cultured
D004723:Endorphins; D010446:Peptide Fragments; C100744:neokyotorphin (1-4); C036450:neo-kyotorphin