Evaluation of antiinflammatory activity of fatty acids of Ocimum sanctum fixed oil.
Ocimum sanctum fixed oil and linolenic acid were found to possess significant antiinflammatory activity against PGE2, leukotriene and arachidonic acid-induced paw edema. Plant lipids like linseed oil and soyabean oil containing linolenic acid when tested along with O. sanctum fixed oil, also showed significant inhibition of carrageenan-induced paw edema. The results suggest that linolenic acid present in O. sanctum fixed oil has the capacity to block both the cyclooxygenase and lipoxygenase pathways of arachidonate metabolism and could be responsible for the antiinflammatory activity of the oil.
Singh
S
S
College of Pharmacy (University of Delhi) Pushp Vihar, New Delhi, India.
Majumdar
D K
DK
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology; D004487:Edema / Q000188:drug therapy; D005227:Fatty Acids / Q000494:pharmacology*; D016859:Lipoxygenase Inhibitors / Q000494:pharmacology; D018649:Ocimum basilicum / Q000737:chemistry*; D010938:Plant Oils / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D000894:Anti-Inflammatory Agents, Non-Steroidal; D016861:Cyclooxygenase Inhibitors; D005227:Fatty Acids; D016859:Lipoxygenase Inhibitors; D010938:Plant Oils