title: Neuromotor changes in Alzheimer's disease: implications for patient care.
abstract: As a result of the neuropathologic process of Alzheimer's disease (AD), significant changes occur in neuromotor function (e.g., paratonia and compulsive grasping). These changes become manifest in the moderately severe stage of AD, when patients begin to require ongoing assistance with activities of daily life (ADL), and they are prominent in the severe stage of AD, when patients are continuously dependent on a caregiver. Patients in these stages often display behavioral disturbances during care activities. These disturbing behaviors result not only from cognitive impairment, but also from a patient's physical inability to cooperate with the caregiver. When care management strategies take into account the characteristic physical restrictions resulting from the neuromotor changes that accompany advanced AD, the caregiving process may be significantly facilitated.
authors.affiliation: Aging and Dementia Research Center, New York University Medical Center, New York 10016, USA.
authors.forename: L E
authors.initials: LE
authors.lastname: Souren
authors.forename: E H
authors.initials: EH
authors.lastname: Franssen
authors.forename: B
authors.initials: B
authors.lastname: Reisberg
mesh_terms: D000203:Activities of Daily Living; D000544:Alzheimer Disease / Q000150:complications* / Q000503:physiopathology; D017028:Caregivers / Q000592:standards; D006801:Humans; D019957:Motor Skills Disorders / Q000209:etiology*; D009127:Muscle Rigidity / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy; D005791:Patient Care / Q000379:methods*; D012021:Reflex, Abnormal / Q000502:physiology; D012720:Severity of Illness Index