Reserpine effects on neurotransmitters in chick heart during growth.
Effects of tranquilizing agents on neurotransmitters in the heart have not been widely studied. Thus, the effect of intraperitoneal injection of reserpine, (2.5 mg/kg bw) on the concentrations of excitatory (glutamic acid, glutamine, aspartic acid, asparagine), inhibitory (GABA, glycine, alanine, taurine), neurotransmitters as well as the enzymes (GOT and GPT) and total protein were measured in both heart and serum chicks at different ages (1, 7, 30, 90 and 180 days). Reserpine induced a decrease in the excitatory amino acids and an increase in GABA in both heart and serum in most ages. Glycine and alanine increased in the heart and decreased in serum. Taurine increased in the heart of young ages (1 and 7 days) and decreased in older ones (90 and 180 days), however, it decreased in serum of most ages. Both GOT and GPT increased in heart but, in serum, GOT increased and GPT decreased in most ages. Total protein increased in the heart of young chicks and decreased in the 90- and 180-day-old chicks. In conclusion, reserpine induced a parallel decrease in the ratio glutamate, glutamine, aspartate/GABA in both myocardial tissue and serum of the different age groups. Changes observed in neurotransmitters of the heart suggest that these amino acids may play a similar role in the myocardial tissue, as is described in the central nervous system.
Ahmed
N A
NA
Department of Biology, Faculty of Science, United Arab Emirates University, Al-Ain, United Arab Emirates.
Radwan
N M
NM
al-Zahaby
A S
AS
Abd el-Salam
M M
MM
D000375:Aging / Q000378:metabolism*; D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D000831:Animals, Newborn / Q000254:growth & development / Q000378:metabolism; D001224:Aspartic Acid / Q000378:metabolism; D002645:Chickens / Q000254:growth & development* / Q000378:metabolism*; D007274:Injections, Intraperitoneal; D009124:Muscle Proteins / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism*; D018377:Neurotransmitter Agents / Q000378:metabolism*; D012110:Reserpine / Q000494:pharmacology*; D014149:Tranquilizing Agents / Q000494:pharmacology*; D000637:Transaminases / Q000378:metabolism; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D000596:Amino Acids; D009124:Muscle Proteins; D018377:Neurotransmitter Agents; D014149:Tranquilizing Agents; D001224:Aspartic Acid; D005680:gamma-Aminobutyric Acid; D012110:Reserpine; D000637:Transaminases