title: Concealed air leak associated with large tidal volumes in partial liquid ventilation.
abstract: Current ventilator strategies aim at maintaining an open lung and limiting both peak inspiratory pressures and tidal volumes to avoid alveolar distension. Perfluorocarbons, as well as being excellent solvents for oxygen and carbon dioxide, have the unique properties of being able to recruit dependent lung regions and improve pulmonary mechanics. Optimal ventilator strategies for partial liquid ventilation (PLV) have not yet been clearly defined. In the surfactant-depleted rabbit model, an approach involving a large tidal volume (VT) (15 ml/kg) and lung filled to FRC with perfluorocarbon (PFC) was compared with strategies involving a moderate VT (9 ml/kg) and partially filled lung (6 ml/kg), a moderate VT (9 ml/kg) and lung filled to FRC with PFC, and a large VT (15 ml/kg) and partially filled lung (6 ml/kg). PEEP was maintained at 5 cm H2O except in the moderate VT, partial-filling group, in which a PEEP of 9 cm H2O was used to maintain the rabbits for the duration of the experiment. Oxygenation was satisfactory in all groups, and peak inspiratory pressures were not significantly different. However, five of the 13 animals in the large-VT, PFC-filled lung group died of a pneumothorax prior to completion of the experiment. Of the eight animals in this group surviving the experiment, two had radiographic evidence of pneumothoraces, with an additional three animals having autopsy evidence of air leak. Of the 22 animals in the other groups, all survived with the exception of a single rabbit in the large VT, partial-filling group, which had both radiographic and autopsy evidence of air leak. We conclude that there is a significant risk of barotrauma in a PLV strategy in which a large VT is used in association with a lung filled to FRC with perfluorocarbon. Adequate gas exchange can be achieved with alternative ventilation strategies in combination with PLV.
authors.affiliation: Department of Critical Care Medicine, Hospital for Sick Children, Toronto, Ontario, Canada.
authors.forename: P N
authors.initials: PN
authors.lastname: Cox
authors.forename: H
authors.initials: H
authors.lastname: Frndova
authors.forename: P S
authors.initials: PS
authors.lastname: Tan
authors.forename: T
authors.initials: T
authors.lastname: Nakamura
authors.forename: K
authors.initials: K
authors.lastname: Miyasaka
authors.forename: Y
authors.initials: Y
authors.lastname: Sakurai
authors.forename: W
authors.initials: W
authors.lastname: Middleton
authors.forename: D
authors.initials: D
authors.lastname: Mazer
authors.forename: A C
authors.initials: AC
authors.lastname: Bryan
mesh_terms: D000818:Animals; D001469:Barotrauma / Q000000981:diagnostic imaging / Q000209:etiology*; D004195:Disease Models, Animal; D005466:Fluorocarbons; D005652:Functional Residual Capacity; D055370:Lung Injury; D008297:Male; D011030:Pneumothorax / Q000000981:diagnostic imaging / Q000209:etiology*; D011175:Positive-Pressure Respiration / Q000009:adverse effects* / Q000379:methods*; D011659:Pulmonary Gas Exchange; D011817:Rabbits; D011859:Radiography; D015656:Respiratory Mechanics; D013990:Tidal Volume
chemical_list: D005466:Fluorocarbons