title: Closure of a ventricular septal defect in a patient with von Willebrand disease.
abstract: Few reports of open heart surgery being performed in patients with von Willebrand disease (vWD) have been documented. We describe herein the case of a 5-year-old girl with a ventricular septal defect (VSD) and vWD who underwent patch closure under cardiopulmonary bypass (CPB). The hematological parameters relating to vWD, namely, factor VIII, von Willebrand factor, and factor VIII-related antigen were monitored perioperatively. These laboratory findings were elevated after the termination of CPB, and consistently maintained within the normal range for 4 months postoperatively. The operation was successfully completed without the administration of factor VIII concentrates or homologous blood products.
authors.affiliation: Department of Thoracic and Cardiovascular Surgery, Niigata City General Hospital, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Tatebe
authors.forename: H
authors.initials: H
authors.lastname: Kanazawa
authors.forename: Y
authors.initials: Y
authors.lastname: Yamazaki
authors.forename: E
authors.initials: E
authors.lastname: Aoki
authors.forename: Y
authors.initials: Y
authors.lastname: Sakurai
authors.forename: H
authors.initials: H
authors.lastname: Miyamura
mesh_terms: D002315:Cardiopulmonary Bypass; D002675:Child, Preschool; D005169:Factor VIII / Q000032:analysis; D005260:Female; D006345:Heart Septal Defects, Ventricular / Q000150:complications* / Q000601:surgery*; D006801:Humans; D014842:von Willebrand Diseases / Q000097:blood / Q000150:complications*; D014841:von Willebrand Factor / Q000032:analysis
chemical_list: D014841:von Willebrand Factor; D005169:Factor VIII