title: Impact of conditioning regimens on salivary function, caries-associated microorganisms and dental caries in children after bone marrow transplantation. A 4-year longitudinal study.
abstract: Salivary function, dental caries and caries-associated salivary microorganisms were investigated in children undergoing BMT during a 4-year longitudinal study. Fourteen children were conditioned with CY and TBI and 12 with CY with or without BU. Four years after BMT the mean salivary secretion rate was 1.3 +/- 0.7 ml/min in the chemotherapy group, compared to 0.7 +/- 0.5 in the TBI/CY group (P < 0.05). The mean salivary secretion rate fell from 0.9 +/- 0.5 ml/min before TBI to 0.2 +/- 0.1 after 3 months (P < 0.01), 0.3 +/- 0.3 ml/min after 6 months (P < 0.01) and 0.5 +/- 0.6, 1 year after TBI (P < 0.05). Mean reduction in stimulated salivary flow 3 months after TBI was 78% in the TBI/CY group compared to 36% in the chemotherapy group (P < 0.05). Children conditioned with chemotherapy showed an increased salivary flow compared to baseline; this was not found in TBI-treated children, suggesting that damage to the salivary glands may be permanent. Four years after BMT, children conditioned with TBI had significantly higher counts of mutans streptococci (P < 0.05) and lactobacilli (P < 0.01) compared to age-matched controls. However, the prevalence of dental caries did not differ between children conditioned with TBI, chemotherapy and healthy controls.
authors.affiliation: Department of Pediatric Dentistry, Karolinska Institutet, Stockholm, Sweden.
authors.forename: G
authors.initials: G
authors.lastname: Dahllöf
authors.forename: M
authors.initials: M
authors.lastname: Bågesund
authors.forename: O
authors.initials: O
authors.lastname: Ringdén
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D015169:Colony Count, Microbial; D003520:Cyclophosphamide / Q000009:adverse effects; D003731:Dental Caries / Q000382:microbiology*; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D012463:Saliva / Q000378:metabolism* / Q000382:microbiology* / Q000528:radiation effects; D019172:Transplantation Conditioning / Q000009:adverse effects*; D014916:Whole-Body Irradiation / Q000009:adverse effects
chemical_list: D003520:Cyclophosphamide