Evidence of apoptotic procedure in deafferented striatum after cortical injury in young adult rats.
In denervated striatum after excitotoxic cortical lesion in young adult rats, apoptotic cells, though quite few, were observed by TUNEL 2 weeks after surgery. Also, prominent expressions of p53 were observed at the same time. These data indicate that apoptotic procedure may be involved in the denervation-induced degeneration even in young adults.
Isono
M
M
Department of Neurosurgery, Oita Medical University, Japan. isonom@oita-med.ac.jp
Wakabayashi
Y
Y
Fujiki
M
M
Inoue
R
R
Asakuno
K
K
Hori
S
S
D000818:Animals; D017209:Apoptosis / Q000276:immunology*; D001930:Brain Injuries / Q000503:physiopathology*; D003342:Corpus Striatum / Q000473:pathology*; D004195:Disease Models, Animal; D007150:Immunohistochemistry; D009410:Nerve Degeneration / Q000276:immunology; D051381:Rats; D017208:Rats, Wistar; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism
D016159:Tumor Suppressor Protein p53