title: [Influence of fluid replacement on serum magnesium concentration and proper magnesium supplementation during general anesthesia].
abstract: We have studied the influence of fluid replacement on serum magnesium (Mg2+) concentrations, and studied proper Mg2+ supplementation during general anesthesia. Thirty eight patients undergoing elective surgery randomly received: Mg(2+)-free acetated Ringer solution (Group I, n = 15), acetated Ringer solution containing 0.5 mmol.l-1 of Mg2+ (Group II, n = 6), 1.0 mmol.l-1 of Mg2+ (Group III, n = 7), 2.0 mmol.l-1 of Mg2+ (Group IV, n = 6), or 4.0 mmol.l-1 of Mg2+ (Group V, n = 4). Measurements were made on serum and urine Mg2+ concentrations during anesthesia. In Group I, the serum Mg2+ concentrations decreased in correspondence with the water balance. It is suggested that dilution due to the fluid replacement induced the reduction in serum Mg2+ concentrations since the observed urine Mg2+ concentrations were negligible. In Group II-V, the reduction in serum Mg2+ concentrations was inhibited by Mg2+ supplementation, and the serum Mg2+ concentrations remained unchanged in Group IV. We conclude the Mg2+ supplementation is required during anesthesia when a large amount of fluid is infused.
authors.affiliation: Department of Anesthesiology, Toyama Medical and Pharmaceutical University School of Medicine.
authors.forename: R
authors.initials: R
authors.lastname: Sasaki
authors.forename: K
authors.initials: K
authors.lastname: Hirota
authors.forename: K
authors.initials: K
authors.lastname: Nakamaru
authors.forename: A
authors.initials: A
authors.lastname: Masuda
authors.forename: T
authors.initials: T
authors.lastname: Satone
authors.forename: Y
authors.initials: Y
authors.lastname: Ito
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000768:Anesthesia, General; D005260:Female; D005440:Fluid Therapy; D006801:Humans; D007552:Isotonic Solutions; D008274:Magnesium / Q000008:administration & dosage* / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D014882:Water-Electrolyte Balance
chemical_list: D007552:Isotonic Solutions; C028570:Ringer's acetate; D008274:Magnesium