title: Bioactivity of ferrimagnetic glass-ceramics in the system FeO-Fe2O3-CaO-SiO2.
abstract: Bioactive and ferrimagnetic glass-ceramics are useful as thermoseeds for hyperthermia treatment of cancer. A heat treatment of a 40(FeO, Fe2O3)-60CaO x SiO2 wt% glass gives a ferrimagnetic glass-ceramic containing 36 wt% magnetite in a CaO x SiO2 matrix. However, it does not show bioactivity since a small amount of iron ion remains in the matrix. In the present study, bioactivities of ferrimagnetic glass-ceramics which were prepared by heat treatment of glasses of the composition 40(FeO, Fe2O3)-60CaO x SiO2 (wt%) with various components added at 100:3 weight ratio were evaluated in vitro by examining bone-like apatite formation on their surfaces in a simulated body fluid. It was found that glass-ceramics with Na2O or B2O3 added in combination with P2O5 show bioactivity.
authors.affiliation: Faculty of Engineering, Kyoto University, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Ebisawa
authors.forename: F
authors.initials: F
authors.lastname: Miyaji
authors.forename: T
authors.initials: T
authors.lastname: Kokubo
authors.forename: K
authors.initials: K
authors.lastname: Ohura
authors.forename: T
authors.initials: T
authors.lastname: Nakamura
mesh_terms: D001031:Apatites / Q000378:metabolism; D001672:Biocompatible Materials / Q000737:chemistry* / Q000378:metabolism; D018786:Bone Substitutes / Q000737:chemistry* / Q000378:metabolism; D002516:Ceramics / Q000737:chemistry* / Q000378:metabolism; D005290:Ferric Compounds / Q000737:chemistry; D052203:Ferrosoferric Oxide; D006358:Hot Temperature; D006801:Humans; D007501:Iron / Q000737:chemistry; D010087:Oxides / Q000737:chemistry; D010949:Plasma / Q000737:chemistry / Q000378:metabolism*; D014961:X-Ray Diffraction
chemical_list: D001031:Apatites; D001672:Biocompatible Materials; D018786:Bone Substitutes; D005290:Ferric Compounds; D010087:Oxides; C001215:ferrite; C023506:Glass ceramics; D007501:Iron; D052203:Ferrosoferric Oxide