title: Frequent hepatic involvement in adult T cell leukemia: comparison with non-Hodgkin's lymphoma.
abstract: We examined 111 patients with acute type- or lymphoma type-adult T-cell leukemia (ATL) and compared them with 106 patients with non-Hodgkin's lymphoma (NHL). In addition to skin involvement and hypercalcemia which are already known to be frequent in ATL, ATL patients showed an higher incidence of hepatic involvement. There was more frequent palpable hepatomegaly, higher total bilirubin, GOT, GPT, lactate dehydrogenase (LDH), and alkaline phosphatase values in ATL than in NHL patients (p < 0.0001). Among 36 autopsied liver samples, invasion of ATL cells was confirmed in 22 cases. ATL patients with impaired hepatic function showed shorter survival times than patients without hepatic dysfunction. Moreover, ATL patients showed a worse performance status (PS), a higher incidence of lytic bone lesions, lower total protein (TP) and serum albumin levels than NHL patients. This invasive characters of ATL cells and consequent impaired general condition seemed to be factors affecting the poor prognosis recorded in ATL.
authors.affiliation: Department of Laboratory Medicine, Atomic Disease Institute, Nagasaki University School of Medicine, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Yamada
authors.forename: S
authors.initials: S
authors.lastname: Kamihira
authors.forename: K
authors.initials: K
authors.lastname: Murata
authors.forename: M
authors.initials: M
authors.lastname: Yamamura
authors.forename: T
authors.initials: T
authors.lastname: Maeda
authors.forename: K
authors.initials: K
authors.lastname: Tsukasaki
authors.forename: T
authors.initials: T
authors.lastname: Jubash
authors.forename: S
authors.initials: S
authors.lastname: Atogami
authors.forename: H
authors.initials: H
authors.lastname: Sohda
authors.forename: T
authors.initials: T
authors.lastname: Taguchi
authors.forename: M
authors.initials: M
authors.lastname: Tomonaga
mesh_terms: D000328:Adult; D006801:Humans; D015458:Leukemia, T-Cell / Q000473:pathology* / Q000628:therapy; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000473:pathology* / Q000628:therapy; D008113:Liver Neoplasms / Q000473:pathology* / Q000628:therapy; D008228:Lymphoma, Non-Hodgkin / Q000473:pathology* / Q000628:therapy; D008875:Middle Aged; D011379:Prognosis; D016896:Treatment Outcome