Ageing: effects on oxidative function of skeletal muscle in vivo.
31P magnetic resonance spectroscopy studies were carried out on calf muscle of 144 normal male and female subjects age 20-83 years in order to investigate age-related changes in muscle metabolism. Compared to the young adults (20-29 years), oxidative capacity was higher in the children (6-12 years) and was significantly decreased in the elderly (70-83 years). In the adults, the intracellular pH change during exercise diminished with increasing age, resulting in higher calculated free [ADP] and possibly serving as an adaptive mechanism to stimulate mitochondrial ATP production. Children also had higher pH and [ADP] in exercise, but unlike results from the elderly, this was associated with higher oxidative capacity and more rapid metabolic recovery from exercise.
Taylor
D J
DJ
MRC Biochemical and Clinical Magnetic Resonance Unit, Oxford Radcliffe Hospital, UK.
Kemp
G J
GJ
Thompson
C H
CH
Radda
G K
GK
D000244:Adenosine Diphosphate / Q000378:metabolism*; D000255:Adenosine Triphosphate / Q000378:metabolism*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D002648:Child; D015444:Exercise; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000378:metabolism*; D010084:Oxidation-Reduction; D012737:Sex Factors
D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate