Nematophin, a novel antimicrobial substance produced by Xenorhabdus nematophilus (Enterobactereaceae).
A new antibiotic, nematophin, was isolated from strain BC1 of Xenorhabdus nematophilus and detected in all strains of X. nematophilus studied. Its structure is fully established as 3-indoleethyl (3'-methyl-2'-oxo)pentanamide by extensive spectroscopic study. The production of nematophin is affected by the strain type and culture conditions. The compound shows strong in vitro bioactivity against a series of fungal and bacterial species.
Li
J
J
Department of Biological Sciences, Simon Fraser University, Vancouver, B.C., Canada. jli@sfu.ca
Chen
G
G
Webster
J M
JM
D004755:Enterobacteriaceae / Q000378:metabolism*; D005285:Fermentation; D005658:Fungi / Q000187:drug effects; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D007211:Indoles / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure
D007211:Indoles; C109330:nematophin