The binding of both [3H]nemonapride and [3H]raclopride is increased in schizophrenia.
We performed a postmortem autoradiographic study to compare the density of dopamine D4-like sites in caudate putamen section from age-matched schizophrenia (n = 15) and control (n = 15) populations. The densities of the D4-like sites were estimated by subtracting the density of [3H]raclopride (binding D2 and D3 receptors) from the density of [3H]nemonapride (binding D2, D3, and D4 receptors). The findings revealed that in the schizophrenia population there was a significant increase in the binding of both [3H]nemonapride (2.3-fold) and [3H]raclopride (1.9-fold). In addition, in the schizophrenia population the density of D4-like sites was increased 2.6-fold.
Marzella
P L
PL
Rebecca L. Cooper Research Laboratories, Mental Health Research Institute of Victoria, Melbourne, Australia.
Hill
C
C
Keks
N
N
Singh
B
B
Copolov
D
D
D000328:Adult; D000368:Aged; D014150:Antipsychotic Agents / Q000493:pharmacokinetics*; D001345:Autoradiography; D001549:Benzamides / Q000493:pharmacokinetics*; D002421:Caudate Nucleus / Q000473:pathology; D002540:Cerebral Cortex / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011699:Putamen / Q000473:pathology; D020891:Raclopride; D017448:Receptors, Dopamine D2 / Q000378:metabolism*; D050637:Receptors, Dopamine D3; D050638:Receptors, Dopamine D4; D012016:Reference Values; D012457:Salicylamides / Q000493:pharmacokinetics*; D012559:Schizophrenia / Q000473:pathology*
D014150:Antipsychotic Agents; D001549:Benzamides; C493593:DRD3 protein, human; C493599:DRD4 protein, human; D017448:Receptors, Dopamine D2; D050637:Receptors, Dopamine D3; D012457:Salicylamides; D050638:Receptors, Dopamine D4; D020891:Raclopride; C030265:nemonapride