[Recent advances in the molecular biological basis of alloantigen systems on white blood cells].
Alloantigen systems on leukocytes are constitutive in clinical and transfusion medicine. Three-dementional structures of HLA class I(A, B, C) and class II(DR, DQ, DP) molecules have disclosed 6 pockets(A, B, C, D, E, F) on class I and 5 pockets(P1, P4, P6, P7, P9) on class II for antigenic peptides binding. Numbers of both HLA alleles and newly identified HLA genes are increasing. HLA-G is expressed solely on non-villous trophoblasts and involved in the pregnancy. HLA-H is responsible for hereditary hemochromatosis. Polymorphic FcRIII molecules expressed on granulocytes and NK cells are involved in allo- and auto-immune granulocytepenia. Molecular biological study will provide a functional significance of polymorphic leukocyte alloantigen systems.
Kuwata
S
S
Third Department of Internal Medicine, Teikyo University School of Medicine.
D005260:Female; D006098:Granulocytes / Q000276:immunology*; D006680:HLA Antigens / Q000235:genetics*; D006801:Humans; D007519:Isoantigens / Q000235:genetics*; D007694:Killer Cells, Natural / Q000276:immunology; D011247:Pregnancy
D006680:HLA Antigens; D007519:Isoantigens