Idiopathic CD4+ T-lymphocytopenia in a non-Hodgkin's lymphoma patient.
We report a case of idiopathic CD4+ T-lymphocytopenia with malignant lymphoma (diffuse large, B-cell type) for which there was no evidence of human immunodeficiency virus type 1 or type 2 infection and no other known causes of immunodeficiency. She had never suffered from any opportunistic infection until the diagnosis of malignant lymphoma was made, and the CD4+ T-lymphocytopenia persisted after complete remission of the lymphoma. As the clinical features and immune status of the patient differed from those associated with the acquired immunodeficiency syndrome (AIDS)-related syndrome, we conclude that immunodeficiency in this case did not contribute to the opportunistic infection but may have been associated with the genesis of malignant lymphoma.
Hanamura
I
I
Second Department of Internal Medicine, Nagoya City University Medical School.
Wakita
A
A
Harada
S
S
Tsuboi
K
K
Komatsu
H
H
Banno
S
S
Iwaki
O
O
Takeuchi
G
G
Nitta
M
M
Ueda
R
R
D015496:CD4-Positive T-Lymphocytes / Q000378:metabolism / Q000473:pathology; D017074:Common Variable Immunodeficiency / Q000473:pathology; D005260:Female; D006801:Humans; D018655:Lymphocyte Count; D008228:Lymphoma, Non-Hodgkin / Q000150:complications*; D008875:Middle Aged; D018344:T-Lymphocytopenia, Idiopathic CD4-Positive / Q000150:complications* / Q000473:pathology