[Basedow's disease in an adolescent with histiocytosis X].
BACKGROUND
Immunological dysfunction is known to be present in Langerhans cell histiocytosis; some autoimmune diseases with autoantibodies associated with this condition have already been described. This immunological dysfunction could play a role in the Langerhans cell histiocytosis pathogenesis.


METHODS
A 13 year-old boy presented a multifocal bone Langerhans cell histiocytosis associated with Graves' syndrome. This last condition was successfully treated with carbimazole while the focal lesions of histiocytosis did not require any treatment.


CONCLUSIONS
This unique association could be explained by the immunological dysfunction seen in Langerhans cell histiocytosis with secondary appearance of thyreo-stimulating antibodies.
Viollet
L
L
Service de pédiatrie, hôpital Raymond-Poincaré, Garches, France.
Commare-Nordmann
M C
MC
Langlais
J
J
Polak
M
M
Donadieu
J
J
D000293:Adolescent; D006111:Graves Disease / Q000150:complications* / Q000175:diagnosis; D006646:Histiocytosis, Langerhans-Cell / Q000150:complications* / Q000175:diagnosis / Q000276:immunology; D006801:Humans; D008297:Male