Role of DNA measurements of head and neck tumors.
The measurement of DNA ploidy has been used as a tool to try to determine the prognosis of many neoplasms. DNA ploidy can be determined by flow cytometry or image analysis of a tumor. In squamous carcinomas of the head and neck, a poorer prognosis has been associated with nondiploid tumors. Similar results have been obtained from studies of salivary gland neoplasms. The role of DNA ploidy as a provider of independent information has yet to be determined. With rarer head and neck tumors, measurement of tumor ploidy has yet to be established as a valuable adjunct to routine light microscopic study.
Milroy
C M
CM
Department of Forensic Pathology, University of Sheffield, England.
Ferlito
A
A
Devaney
K O
KO
Rinaldo
A
A
D002294:Carcinoma, Squamous Cell / Q000235:genetics; D004273:DNA, Neoplasm / Q000032:analysis*; D006258:Head and Neck Neoplasms / Q000235:genetics*; D006801:Humans; D011003:Ploidies; D012468:Salivary Gland Neoplasms / Q000235:genetics
D004273:DNA, Neoplasm