title: Development and evaluation of a kit formulation for the preparation of 99mTc-DMP-HSA, a new tracer agent for radionuclide ventriculography.
abstract: This study presents the development of a kit formulation for the preparation of 99mTc-DMP-HSA, followed by a comparison of such kit-prepared 99mTc-DMP-HSA to 99mTc-RBCs in a volunteer. Reconstitution of the labeling kits with up to 5.55 GBq 99mTc afforded 99mTc-DMP-HSA preparations with a > 95% radiochemical purity for up to 8 h. Only minor differences were observed in the global distribution of both tracer agents, whereas the calculated ejection fractions were almost identical. The effective dose equivalent of 99mTc-DMP-HSA is 8.68 microSv/MBq.
authors.affiliation: Laboratory of Radiopharmaceutical Chemistry, K.U. Leuven, Belgium.
authors.forename: K A
authors.initials: KA
authors.lastname: Verbeke
authors.forename: C W
authors.initials: CW
authors.lastname: Schiepers
authors.forename: D N
authors.initials: DN
authors.lastname: Wyndaele
authors.forename: J A
authors.initials: JA
authors.lastname: Baetens
authors.forename: G N
authors.initials: GN
authors.lastname: Verbeke
authors.forename: M J
authors.initials: MJ
authors.lastname: De Roo
authors.forename: A M
authors.initials: AM
authors.lastname: Verbruggen
mesh_terms: D006801:Humans; D008297:Male; D015609:Organotechnetium Compounds / Q000737:chemistry / Q000493:pharmacokinetics; D011786:Quality Control; D011829:Radiation Dosage; D015635:Radionuclide Ventriculography; D011933:Reagent Kits, Diagnostic; D013438:Sulfhydryl Compounds / Q000737:chemistry / Q000493:pharmacokinetics; D013668:Technetium Tc 99m Aggregated Albumin / Q000737:chemistry / Q000493:pharmacokinetics
chemical_list: D015609:Organotechnetium Compounds; D011933:Reagent Kits, Diagnostic; D013438:Sulfhydryl Compounds; D013668:Technetium Tc 99m Aggregated Albumin; C038842:technetium Tc 99m 2,3-dimercaptopropionic acid