[An acellular pertussis vaccine based on the natural complex of antigens isolated from the supernatant of a synthetic culture medium].
A highly effective technology for obtaining a protective antigenic complex, including the main Bordetella pertussis protective antigens (pertussis toxin, filamentous hemagglutinin, agglutinogens, pertactin and adenylate cyclase) and isolated from the supernatant of B. pertussis cultivation medium, has been developed. A new method for the detoxication of antigenic complex which more available to preserve the protective property was suggested. Experimental batches of monovaccine and adsorbed DPT vaccine with the acellular pertussis component, possessing high protective activity and low histamine-sensitizing properties, have been obtained. The stability of protective properties both in liquid and lyophilized acellular pertussis preparations has been noted.
Zakharova
N S
NS
Remova
T N
TN
Bazhanova
I G
IG
Ozeretskovskaia
M H
MH
Britsina
M V
MV
Shmeleva
E I
EI
Mertsalova
N U
NU
Ermolova
E I
EI
Sukhinova
E E
EE
Bulk
V F
VF
Sirotinskiĭ
A V
AV
Poluiianova
A G
AG
Sviridov
V V
VV
Vartanian
Iu P
IuP
D000818:Animals; D000942:Antigens, Bacterial / Q000276:immunology / Q000302:isolation & purification*; D001886:Bordetella pertussis / Q000276:immunology* / Q000472:pathogenicity; D003470:Culture Media; D015721:Diphtheria-Tetanus-Pertussis Vaccine / Q000276:immunology / Q000302:isolation & purification; D004306:Dose-Response Relationship, Immunologic; D007114:Immunization; D007116:Immunization, Passive; D051379:Mice; D010567:Pertussis Vaccine / Q000276:immunology / Q000302:isolation & purification*; D014774:Virulence / Q000276:immunology; D014917:Whooping Cough / Q000209:etiology / Q000517:prevention & control
D000942:Antigens, Bacterial; D003470:Culture Media; D015721:Diphtheria-Tetanus-Pertussis Vaccine; D010567:Pertussis Vaccine