title: Karyotypic and clinical progression of ANLL in a patient with constitutional der(15;21)(q10;q10).
abstract: A patient with a constitutional chromosomal abnormality who developed acute nonlymphocytic leukemia (ANLL-M4) at the age of 31 is presented. At the time of diagnosis the only acquired chromosomal change was the presence of a small marker chromosome. The patient was studied periodically for 11 years during his illness with no evidence of karyotypic progression, until the last study, when a deletion of the long arm of chromosome 7 was detected.
authors.affiliation: Department of Genetics, National Cancer Institute, Bratislava, Slovakia.
authors.forename: A
authors.initials: A
authors.lastname: Zámecniková
authors.forename: J
authors.initials: J
authors.lastname: Gyárfás
authors.forename: V
authors.initials: V
authors.lastname: Izakovic
authors.forename: P
authors.initials: P
authors.lastname: Krizan
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002869:Chromosome Aberrations; D018450:Disease Progression; D006801:Humans; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology; D008297:Male; D012008:Recurrence