Remacemide hydrochloride reduces cortical lesion volume following brain trauma in the rat.
We evaluated the therapeutic effects of remacemide hydrochloride, an N-methyl-D-aspartate (NMDA) receptor-associated ionophore blocker with sodium channel blocking activity, on cortical lesion volume and memory dysfunction following parasagittal fluid-percussion brain injury in the anesthetized rat. We found that intravenous (i.v.) administration 15 min following injury of remacemide hydrochloride at both 25 and 10 mg/kg significantly reduced posttraumatic cortical lesion volume (P < 0.05), measured at 48 h postinjury using a tetrazolium salt tissue staining technique. However, neither of these doses nor the dosing regimen of 25 mg/kg i.v. 15 min postinjury plus a subcutaneous infusion over 24 h of 20 mg/kg remacemide hydrochloride improved posttraumatic memory function determined by a Morris water maze paradigm.
Smith
D H
DH
Department of Neurosurgery, University of Pennsylvania, Philadelphia 19104-6316, USA. smithdou@mail.med.upenn.edu
Perri
B R
BR
Raghupathi
R
R
Saatman
K E
KE
McIntosh
T K
TK
D000081:Acetamides / Q000008:administration & dosage / Q000627:therapeutic use*; D000818:Animals; D001930:Brain Injuries / Q000188:drug therapy*; D002540:Cerebral Cortex / Q000187:drug effects* / Q000293:injuries / Q000473:pathology; D008297:Male; D008569:Memory Disorders / Q000188:drug therapy; D018696:Neuroprotective Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors*
D000081:Acetamides; D018696:Neuroprotective Agents; D016194:Receptors, N-Methyl-D-Aspartate; C067553:remacemide