[Hyperinsulinism in hyperlipoproteinemia in patients on a chronic hemodialysis program].
The aim of this study was to establish possible hyperinsulinemia, as a consequence of insulin resistance in chronic hemodialysis patients. We examined 45 HD (hemodialysis) patients and 18 healthy subjects. On an empty stomach the following parameters were established: glucose, insulin, triglycerides, total cholesterol, HDL (high-density lipoprotein)-cholesterol and LDL (low-density lipoprotein)-cholesterol. Body mass index and waist-hip ratio were also examined. Hyperlipoproteinemia was established in 22 patients (21 with type IV and 1 with type II b), while 23 patients were normolipidemic. Insulinemia was significantly increased in the group of patients with hyperlipoproteinemia, both comparing normolipidemic patients and healthy subjects (x1 = 20.7; p = 0.0001; x2 = 13.2, p = 0.0001; x3 = 11.3, p = 0.0001). In the group with hyperlipoproteinemia there was a positive correlation between levels of insulinemia and triglyceridemia (r = 0.41, p = 0.05). It can be concluded that hyperinsulinemia in the group of patients with hyperlipoproteinemia, on hemodialysis, is an imperative for treating insulin resistance, and in that way causes of lipoprotein metabolism disorders.
Rasić-Milutinović
Z
Z
Odeljenje za endokrinologiju, Internisticke sluzbe, Klinicki bolnicki centar, Zemun-Beograd.
Perunicić-Peković
G
G
Bokan
L
L
Pljesa
S
S
Ristić
V
V
Tepsić
V
V
D005260:Female; D006801:Humans; D006946:Hyperinsulinism / Q000209:etiology*; D006951:Hyperlipoproteinemias / Q000209:etiology*; D007676:Kidney Failure, Chronic / Q000097:blood / Q000628:therapy; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis / Q000009:adverse effects*