Outcome in pediatric rheumatic disease.
Outcome assessment has been a focus of recent research in rheumatic diseases and in pediatric rheumatology. The establishment of a preliminary core set of outcome variables for juvenile rheumatoid arthritis patients and a preliminary definition of improvement using these variables have been important steps toward standardization of outcome assessment. A population-based epidemiologic study has added to our knowledge of long-term outcome in juvenile arthritis and confirms the chronicity of disease that was found in previous studies. Standardization of outcome assessment in pediatric systemic lupus erythematosus has not been achieved to the same extent as in juvenile rheumatoid arthritis, but renal survival and overall mortality are important outcomes in this disease that are easily quantified. Recent studies of pediatric systemic lupus erythematosus demonstrate similarities with respect to organ involvement and overall survival between adult and pediatric lupus patients.
Graham
T B
TB
Children's Hospital Medical Center, Cincinnati, OH 45229-3039, USA.
Lovell
D J
DJ
D001171:Arthritis, Juvenile / Q000503:physiopathology*; D002648:Child; D006801:Humans; D008137:Longitudinal Studies; D008180:Lupus Erythematosus, Systemic / Q000503:physiopathology*; D017063:Outcome Assessment, Health Care; D014605:Uveitis / Q000503:physiopathology