Prolongation of prothrombin time with the use of indomethacin and warfarin.
A patient with a greatly prolonged international normalised ratio (INR) during the combined use of warfarin and indomethacin is described. In patients on warfarin, non-steroidal anti-inflammatory drugs (NSAIDs) should be avoided as far as possible. If NSAIDs are absolutely necessary, patients should be closely monitored for prolongation of INR and bleeding.
Chan
T Y
TY
Department of Clinical Pharmacology, Prince of Wales Hospital, Shatin, Hong Kong.
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000925:Anticoagulants / Q000008:administration & dosage*; D001778:Blood Coagulation Disorders / Q000139:chemically induced; D000075202:Contraindications; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced; D006801:Humans; D007213:Indomethacin; D008875:Middle Aged; D011517:Prothrombin Time; D014859:Warfarin / Q000008:administration & dosage*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000925:Anticoagulants; D014859:Warfarin; D007213:Indomethacin