Angiogenic and HIV-inhibitory functions of KSHV-encoded chemokines.
Unique among known human herpesviruses, Kaposi's sarcoma-associated herpesvirus (KSHV or HHV-8) encodes chemokine-like proteins (vMIP-I and vMIP-II). vMIP-II was shown to block infection of human immunodeficiency virus-type 1 (HIV-1) on a CD4-positive cell line expressing CCR3 and to a lesser extent on one expressing CCR5, whereas both vMIP-I and vMIP-II partially inhibited HIV infection of peripheral blood mononuclear cells. Like eotaxin, vMIP-II activated and chemoattracted human eosinophils by way of CCR3. vMIP-I and vMIP-II, but not cellular MIP-1alpha or RANTES, were highly angiogenic in the chorioallantoic assay, suggesting a possible pathogenic role in Kaposi's sarcoma.
Boshoff
C
C
Institute of Cancer Research, Chester Beatty Laboratories, London SW3 6JB, UK.
Endo
Y
Y
Collins
P D
PD
Takeuchi
Y
Y
Reeves
J D
JD
Schweickart
V L
VL
Siani
M A
MA
Sasaki
T
T
Williams
T J
TJ
Gray
P W
PW
Moore
P S
PS
Chang
Y
Y
Weiss
R A
RA
D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000821:virology; D018925:Chemokines / Q000235:genetics / Q000378:metabolism / Q000494:pharmacology / Q000502:physiology*; D002634:Chemotaxis, Leukocyte; D002642:Chick Embryo; D004804:Eosinophils / Q000502:physiology; D015497:HIV-1 / Q000502:physiology*; D019288:Herpesvirus 8, Human / Q000235:genetics* / Q000502:physiology; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000821:virology; D019402:Macrophage Inflammatory Proteins / Q000235:genetics / Q000378:metabolism / Q000494:pharmacology / Q000502:physiology*; D009389:Neovascularization, Pathologic / Q000209:etiology*; D009504:Neutrophils / Q000502:physiology; D054397:Receptors, CCR3; D019707:Receptors, Chemokine; D018121:Receptors, Cytokine / Q000819:agonists / Q000378:metabolism; D015728:Receptors, HIV / Q000378:metabolism; D014407:Tumor Cells, Cultured; D014764:Viral Proteins; D014779:Virus Replication
C515350:CCR3 protein, human; D018925:Chemokines; D019402:Macrophage Inflammatory Proteins; D054397:Receptors, CCR3; D019707:Receptors, Chemokine; D018121:Receptors, Cytokine; D015728:Receptors, HIV; D014764:Viral Proteins; C108459:vMIP-1 protein, Human herpesvirus 8; C108059:vMIP-II