[Use of micronucleus tests for screening mutagens and carcinogens].
The induction of micronuclei was studied in the cells of various organs in mice and rats via gavage of 7 carcinogens. It was found that only had cyclophosphamide a pronounced cytogenetic effect in bone marrow cells whereas the others were effective in the cells of other organs (different portions of the gastrointestinal tract, liver, lung). There was a good correlation of organ specificity of the mutagenic and carcinogenic properties of the chemicals. To detect potential carcinogens, micronucleus tests were proposed to be used on cells of different organs in the mammals.
Sycheva
L P
LP
NII of Human Ecology and Environmental Hygiene RAMN, Moscow.
Zhukov
V S
VS
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects; D002273:Carcinogens / Q000633:toxicity*; D004064:Digestive System / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005260:Female; D008099:Liver / Q000187:drug effects; D008168:Lung / Q000187:drug effects; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D015162:Micronucleus Tests / Q000379:methods*; D009153:Mutagens / Q000633:toxicity*; D051381:Rats
D002273:Carcinogens; D009153:Mutagens