title: Classical gene amplifications in human breast cancer are not associated with distant solid metastases.
abstract: To determine the relationship between breast cancer progression and gene amplification, we screened 62 distant metastases and 122 primary breast tumours for the amplification of the proto-oncogenes MYC and ERBB2 and the 11q13 chromosomal region. Surprisingly, solid metastases showed an absence of gene amplification. These results suggest that the amplification of the proto-oncogenes MYC and ERBB2 and the 11q13 chromosomal region seem to be involved mainly in the genesis of the primary breast tumour rather than its progression.
authors.affiliation: Laboratoire d'Oncogénétique, Centre René Huguenin, St-Cloud, France.
authors.forename: K
authors.initials: K
authors.lastname: Driouch
authors.forename: M H
authors.initials: MH
authors.lastname: Champème
authors.forename: M
authors.initials: M
authors.lastname: Beuzelin
authors.forename: I
authors.initials: I
authors.lastname: Bièche
authors.forename: R
authors.initials: R
authors.lastname: Lidereau
mesh_terms: D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology; D002880:Chromosomes, Human, Pair 11; D004273:DNA, Neoplasm / Q000235:genetics*; D051518:Fibroblast Growth Factor 3; D005346:Fibroblast Growth Factors / Q000235:genetics; D005784:Gene Amplification; D018734:Genes, erbB-2; D016258:Genes, mos; D016259:Genes, myc; D006801:Humans; D009362:Neoplasm Metastasis; D010996:Pleural Effusion; D011518:Proto-Oncogene Proteins / Q000235:genetics; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000235:genetics*
chemical_list: D004273:DNA, Neoplasm; D051518:Fibroblast Growth Factor 3; D005346:Fibroblast Growth Factors; D011518:Proto-Oncogene Proteins; D018719:Erb-b2 Receptor Tyrosine Kinases; C496444:FGF3 protein, human