[Malformations of the midline. A case-control study].
Defects of the middle line are an heterogeneous group of congenital malformations due to commune pathogenetic mechanisms. We have made a case-control study about 150 newborns, who have at least 1 defect of the middle line. Results prove an excess of males between the cases, due mostly to hypospadias. We haven't found families with defects of the middle line with x-linked manner of hereditary transmission. We haven't found any particular risk present in cases and not in controls. We haven't found any case with 2 or more middle line defects.
Guala
A
A
Divisione Pediatrica, Ospedale S. Andrea di Vercelli, Italia.
Pastore
G
G
Cerruti Mainardi
P
P
Liverani
E
E
Ghini
T
T
Tagliabue
A
A
Capo
A
A
Quazza
G
G
Cigolotti
A C
AC
Zaffaroni
M
M
Foracchia
P
P
Garassino
L
L
Uasone
R
R
D016022:Case-Control Studies; D002971:Cleft Lip / Q000235:genetics; D002972:Cleft Palate / Q000235:genetics; D000013:Congenital Abnormalities / Q000235:genetics*; D004933:Esophageal Atresia / Q000235:genetics; D004937:Esophageal Fistula / Q000235:genetics; D005260:Female; D005865:Gestational Age; D006801:Humans; D007021:Hypospadias / Q000235:genetics; D007231:Infant, Newborn; D008297:Male; D012737:Sex Factors; D014132:Trachea / Q000002:abnormalities