title: No linkage or association of a VNTR marker in the junction region of the immunoglobulin heavy chain genes in multiple sclerosis.
abstract: Multiple sclerosis (MS) is a demyelinating inflammatory disease of the central nervous system. Autoantibodies are though to participate in the pathogenesis. Previous reports on the role of immunoglobulin (Ig) variable gene segments in MS are contradictory. Here, by using a highly polymorphic variable number tandem repeat (VNTR) marker located in the centre of the IgH chain locus, we demonstrate a lack of linkage and association with MS in 34 multiplex families and 113 sporadic MS patients in Sweden. Stratification for the presence or absence of the MS-associated HLA-Dw2 haplotype did not influence the negative outcome. We conclude that the IgH chain genes are unlikely to play a role in genetic susceptibility to MS in the Swedish population.
authors.affiliation: Department of Neurology, Karolinska Institute, Huddinge University Hospital, Sweden.
authors.forename: A
authors.initials: A
authors.lastname: Ligers
authors.forename: B
authors.initials: B
authors.lastname: He
authors.forename: A
authors.initials: A
authors.lastname: Fogdell-Hahn
authors.forename: O
authors.initials: O
authors.lastname: Olerup
authors.forename: J
authors.initials: J
authors.lastname: Hillert
mesh_terms: D002883:Chromosomes, Human, Pair 14 / Q000235:genetics; D005787:Gene Frequency; D005803:Genes, Immunoglobulin / Q000235:genetics*; D006239:Haplotypes; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics*; D008126:Lod Score; D018598:Minisatellite Repeats; D009103:Multiple Sclerosis / Q000235:genetics* / Q000276:immunology; D019683:Penetrance; D013548:Sweden
chemical_list: D007143:Immunoglobulin Heavy Chains