title: The major sigma factor (RpoD) from Helicobacter pylori and other gram-negative bacteria shows an enhanced rate of divergence.
abstract: Sequence analysis of the Helicobacter pylori major sigma factor (RpoD) shows that it is highly divergent, which may be related to the marked diversity of the H. pylori chromosome. Furthermore, the rate of divergence of RpoD among other gram-negative bacteria is much greater than that among gram-positive bacteria. This suggests that RpoD from gram-negative bacteria is functionally less constrained than that from gram-positive bacteria.
authors.affiliation: Department of Internal Medicine, School of Medicine, University of California, Davis 95616, USA. jvsolnick@ucdavis.edu
authors.forename: J V
authors.initials: JV
authors.lastname: Solnick
authors.forename: L M
authors.initials: LM
authors.lastname: Hansen
authors.forename: M
authors.initials: M
authors.lastname: Syvanen
mesh_terms: D000595:Amino Acid Sequence; D001426:Bacterial Proteins / Q000737:chemistry / Q000235:genetics; D001483:Base Sequence; D002876:Chromosomes, Bacterial / Q000235:genetics; D012321:DNA-Directed RNA Polymerases / Q000737:chemistry / Q000235:genetics*; D019143:Evolution, Molecular; D014644:Genetic Variation; D006090:Gram-Negative Bacteria / Q000737:chemistry / Q000235:genetics*; D006094:Gram-Positive Bacteria / Q000737:chemistry / Q000235:genetics; D016480:Helicobacter pylori / Q000737:chemistry / Q000235:genetics*; D008969:Molecular Sequence Data; D010802:Phylogeny; D012808:Sigma Factor / Q000737:chemistry / Q000235:genetics*
chemical_list: D001426:Bacterial Proteins; D012808:Sigma Factor; C081775:RNA polymerase sigma 70; D012321:DNA-Directed RNA Polymerases