A case of a pony with Cushing's disease.
The pars intermedia of the pituitary gland, and plasma ACTH and cortisol levels in the pony, which was first diagnosed in Japan as indicating equine Cushing's disease, were examined by immunohistochemistry and radioimmunoassay, respectively. The pars intermedia was greatly enlarged and most of its cells were immunoreactive for antisera to both adenocorticotropic hormone (ACTH) and beta-endorphin (beta-End). The plasma ACTH level was elevated when clinical symptoms appeared. The present results reveal that equine Cushing's disease in this pony was induced by the hypersecretion of ACTH and beta-End from the enlarged pars intermedia of the pituitary gland.
Okada
T
T
Department of Veterinary Anatomy, College of Agriculture, Osaka Prefecture University, Japan.
Yuguchi
K
K
Kiso
Y
Y
Morikawa
Y
Y
Nambo
Y
Y
Oikawa
M
M
Sasaki
F
F
D000311:Adrenal Glands / Q000166:cytology / Q000473:pathology*; D000324:Adrenocorticotropic Hormone / Q000032:analysis / Q000097:blood; D000818:Animals; D003480:Cushing Syndrome / Q000097:blood / Q000175:diagnosis / Q000662:veterinary*; D006734:Horse Diseases; D006736:Horses; D006854:Hydrocortisone / Q000032:analysis / Q000097:blood; D007150:Immunohistochemistry; D010902:Pituitary Gland / Q000166:cytology / Q000473:pathology*; D011863:Radioimmunoassay; D012016:Reference Values; D015383:Zona Fasciculata / Q000166:cytology / Q000473:pathology
D000324:Adrenocorticotropic Hormone; D006854:Hydrocortisone