title: Haloperidol effects on Na current in acutely isolated rat retinal ganglion cells.
abstract: Suppressive effects of haloperidol, one of the neuroleptic compounds that acts on the transient Na current (INa,t) were studied in freshly isolated 5-10-day-old rat retinal ganglion cells using a whole-cell patch clamp technique. High doses of haloperidol reversibly and dose dependently (2-200 mumol ) reduced the peak amplitude of INa,t. The half-inhibition dose was 27.1 mumol. The inactivation curve of INa,t was shifted toward a hyperpolarizing direction by about 42% when the amplitude was suppressed with 20 mumol haloperidol. This indicates that haloperidol suppression of INa,t is probably affected through changes in the inactivation of Na channels.
authors.affiliation: Department of Ophthalmology, Faculty of Medicine, Mie University, Tsu, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Ito
authors.forename: Y
authors.initials: Y
authors.lastname: Nishimura
authors.forename: Y
authors.initials: Y
authors.lastname: Uji
authors.forename: T
authors.initials: T
authors.lastname: Yamamoto
mesh_terms: D000818:Animals; D018492:Dopamine Antagonists / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006220:Haloperidol / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D008564:Membrane Potentials / Q000502:physiology; D018408:Patch-Clamp Techniques; D010477:Perfusion; D010784:Photomicrography; D051381:Rats; D017207:Rats, Sprague-Dawley; D012165:Retinal Ganglion Cells / Q000187:drug effects / Q000502:physiology*; D015222:Sodium Channels / Q000502:physiology*
chemical_list: D018492:Dopamine Antagonists; D015222:Sodium Channels; D006220:Haloperidol