Chiasmal glioma in neurofibromatosis type 1 with severe visual loss regained with radiation.
Children with neurofibromatosis type 1 (NFI) and chiasmal gliomas are often considered unlikely to experience progressive visual loss. However, this may not be true. We report a 5-year, 6-month-old boy, with recently diagnosed NF1, who had a chiasmal glioma diagnosed after neuroimaging. He subsequently experienced rapid visual acuity loss. His vision improved significantly after irradiation. The controversy surrounding radiotherapy for chiasmal glioma is discussed.
Adams
C
C
Department of Pediatric Neurology, Alberta Childrens Hospital, University of Calgary, Canada.
Fletcher
W A
WA
Myles
S T
ST
D002675:Child, Preschool; D016371:Cranial Irradiation; D003390:Cranial Nerve Neoplasms / Q000175:diagnosis* / Q000532:radiotherapy; D005500:Follow-Up Studies; D005910:Glioma / Q000175:diagnosis* / Q000532:radiotherapy; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009456:Neurofibromatosis 1 / Q000175:diagnosis* / Q000532:radiotherapy; D009897:Optic Chiasm / Q000473:pathology; D014057:Tomography, X-Ray Computed; D014792:Visual Acuity / Q000528:radiation effects