Transport of glutathione S-conjugates in Escherichia coli.
There are no reports concerning glutathione-S-conjugates transport in prokaryotic cells, although many studies have been performed in eukaryotic systems. This study demonstrates that glutathione S-conjugates (2,4-dinitrophenyl-S-glutathione and bimane-S-glutathione) are transported also out of Escherichia coli K12 cells. This transport is inhibited by vanadate, fluoride and other inhibitors of glutathione S-conjugate transport in mammalian cells suggesting a similarity of this process to that known in eukaryotes.
Kałuzna
A
A
Department of Molecular Biophysics, University of Lódź, Poland.
Bartosz
G
G
D001693:Biological Transport, Active / Q000187:drug effects; D001643:Bridged Bicyclo Compounds / Q000378:metabolism*; D004926:Escherichia coli / Q000187:drug effects / Q000378:metabolism*; D005459:Fluorides / Q000494:pharmacology; D005978:Glutathione / Q000031:analogs & derivatives* / Q000378:metabolism; D007700:Kinetics; D011339:Probenecid / Q000494:pharmacology; D014475:Uncoupling Agents / Q000494:pharmacology; D014638:Vanadates / Q000494:pharmacology
D001643:Bridged Bicyclo Compounds; D014475:Uncoupling Agents; C080120:glutathione-bimane; C030190:S-(2,4-dinitrophenyl)glutathione; D014638:Vanadates; D005978:Glutathione; D011339:Probenecid; D005459:Fluorides