Segregation analysis of prostate cancer in Sweden: support for dominant inheritance.
Several epidemiologic studies have shown familial aggregation of prostate cancer. To assess the nature of familial clustering of prostate cancer, a complex segregation analysis was performed on a population-based sample of 2,857 nuclear families ascertained through an affected father diagnosed with prostate cancer in Sweden during 1959-1963. The segregation analysis, using a large, unselected population of prostate cancer families, revealed that the observed clustering of prostate cancer was best explained by a high risk allele inherited in a dominant mode, with a high population frequency (1.67%) and a moderate lifetime penetrance (63%). This study confirms the result from one earlier published segregation analysis and provides the context for interpreting the recently published linkage of hereditary prostate cancer families to chromosome 1q 24-25 (HPC1).
Grönberg
H
H
Department of Oncology, Umeå University, Sweden.
Damber
L
L
Damber
J E
JE
Iselius
L
L
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D005787:Gene Frequency; D005799:Genes, Dominant; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D017720:Molecular Epidemiology; D010375:Pedigree; D010641:Phenotype; D011471:Prostatic Neoplasms / Q000453:epidemiology* / Q000235:genetics*; D012307:Risk Factors; D013548:Sweden / Q000453:epidemiology