title: Assessment of the functional capacity for intracellular death and phagocytosis of polymorphonuclear cells in healthy neonates.
abstract: The objective of this study was to assess the functional capacity for intracellular death (ID) and/or phagocytic index (PI) of polymorphonuclear cells of 24-h-old healthy newborns with respect to the PMN cells of adults using the same standard exogenous source of opsonins. The ID and PI techniques were standardized and 2-3 ml of blood were used. No differences were found in the percentages of ID, P, PI among the PMNs of the newborns and those of the adults: 43.95 +/- 15.70 vs. 44.56 +/- 8.43 for ID; 38.96 +/- 14.34 vs. 39.00 +/- 14.54 for P; 1.71 +/- 0.54 vs. 1.73 0.45 for PI, respectively. It was concluded that the PMNs of 24-h newborns have an ID, P, PI functionality comparable to adult PMNs; differences observed in PMN function in newborns may be due to humoral deficiencies (opsonins).
authors.affiliation: Departmento de Infectología e Inmunología Perinatal, Instituto Nacional de Perinatologia, México, D.F.
authors.forename: G
authors.initials: G
authors.lastname: Del Rey-Pineda
authors.forename: M V
authors.initials: MV
authors.lastname: Gómez-González
authors.forename: F
authors.initials: F
authors.lastname: Solórzano-Santos
authors.forename: J L
authors.initials: JL
authors.lastname: Arredondo-García
mesh_terms: D000328:Adult; D000375:Aging / Q000097:blood; D003602:Cytotoxicity, Immunologic; D006801:Humans; D007231:Infant, Newborn / Q000097:blood* / Q000276:immunology; D009504:Neutrophils / Q000276:immunology / Q000382:microbiology / Q000502:physiology*; D010587:Phagocytosis / Q000502:physiology*