[Possible involvement of donor-derived B cells in development of post-transfusion graft-versus-host disease].
Post-transfusion graft-versus-host disease(PT-GVHD) is one of the most severe side effects of blood transfusion. To clarify the mechanism of development PT-GVHD, we characterized possible effector lymphocyte clones, presumably involved in the occurrence of PT-GVHD. By lymphocyte cloning from peripheral blood of a PT-GVHD patient, not only donor-derived cytotoxic T cell clones but also donor-derived B cell clones were established. The B cell clones produce cytotoxic IgG, directed against the patient's class II HLA. It was strongly suggested that donor-derived B cells, through production of cytotoxic IgG directed against the patient's HLA, were involved in the pathogenesis of the PT-GVHD in this case.
Nishimura
M
M
Japanese Red Cross Central Blood Center.
Akaza
T
T
Tadokoro
K
K
Juji
T
T
D001402:B-Lymphocytes / Q000276:immunology*; D001782:Blood Donors; D005260:Female; D006086:Graft vs Host Disease / Q000209:etiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D065227:Transfusion Reaction