A neuropsychological perspective on three schizophrenic patients with midline structural defects.
BACKGROUND
The relationship between midline structural defects and schizophrenia remains unclear, although a number of neuroradiological studies have reported an association between schizophrenia and a range of anomalies.


METHODS
Three patients are reported, each diagnosed with schizophrenia and neuroradiological evidence of midline structural anomalies. MRI scans are reported in conjunction with performance over a range of neuropsychological tests designed to assess frontal and lateralised cognitive functions.


RESULTS
Evidence of anterior dysfunction was present in all three cases, while on an individual basis patients displayed varying patterns of preserved and dysfunctional cognitive processing.


CONCLUSIONS
The reported findings raise a number of interesting issues regarding the nature of hemispheric involvement in schizophrenia.
Edelstyn
N M
NM
University Department of Psychiatry, Queen Elizabeth Psychiatric Hospital, Birmingham.
Oyebode
F
F
Riddoch
M J
MJ
Soppitt
R
R
Moselhy
H
H
George
M
M
D000328:Adult; D061085:Agenesis of Corpus Callosum; D003072:Cognition Disorders / Q000175:diagnosis* / Q000503:physiopathology; D003337:Corpus Callosum / Q000503:physiopathology; D005260:Female; D006801:Humans; D007806:Language Disorders / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008569:Memory Disorders / Q000175:diagnosis / Q000503:physiopathology; D008875:Middle Aged; D009483:Neuropsychological Tests; D010364:Pattern Recognition, Visual / Q000502:physiology; D011340:Problem Solving; D012559:Schizophrenia / Q000175:diagnosis* / Q000503:physiopathology; D012565:Schizophrenic Psychology; D013028:Space Perception / Q000502:physiology; D014786:Vision Disorders / Q000473:pathology; D014796:Visual Perception