title: The consequences of the intracellular retention of pathogen-derived T-cell-independent antigens on protein presentation to T cells.
abstract: Intracellular pathogens can be considered as particulate antigens chemically composed of a complex mixture of T-cell-dependent antigens (TD) (peptides and proteins) and T-cell-independent antigens (TI) (glycolipids and complex polysaccharides). A large range of saccharides (from oligosaccharides to complex polysaccharides) derived from pathogenic microorganisms are being isolated and characterized. They are currently implicated in signaling systems and concomitant host-parasite relationships. However, there are not many structure-function relationships described for these pathogens. This is particularly true of polysaccharides. In this report we have reviewed the role of defined TI antigens in the processing and presentation of defined TD antigens to specific T cells by antigen-presenting cells (APC). We also considered the importance of some of the chemical characteristics shared by different carbohydrates implicated in the inhibition of antigen presentation. These findings are discussed in relation to the clear immunopathological consequences of long retention periods of complex carbohydrate molecules derived from intracellular parasites inside certain APC and the absence of antigen presentation impairment in physiological situations such as the removal of senescent or damaged red blood cells by splenic macrophages or intracellular accumulation of carbohydrates in colostrum and milk macrophages during lactation.
authors.affiliation: Servicio de Inmunología, Hospital Universitario Marqués de Valdecilla, Instituto Nacional de la Salud, Majadahonda (Madrid), Spain.
authors.forename: F
authors.initials: F
authors.lastname: Leyva-Cobián
authors.forename: I M
authors.initials: IM
authors.lastname: Outschoorn
authors.forename: E
authors.initials: E
authors.lastname: Carrasco-Marín
authors.forename: C
authors.initials: C
authors.lastname: Alvarez-Domínguez
mesh_terms: D000818:Animals; D017951:Antigen Presentation; D000938:Antigen-Presenting Cells / Q000276:immunology / Q000378:metabolism; D000955:Antigens, T-Independent / Q000737:chemistry / Q000378:metabolism*; D050260:Carbohydrate Metabolism; D002241:Carbohydrates / Q000737:chemistry / Q000276:immunology; D005260:Female; D006017:Glycolipids / Q000737:chemistry / Q000276:immunology / Q000378:metabolism; D006023:Glycoproteins / Q000737:chemistry / Q000276:immunology / Q000378:metabolism; D000949:Histocompatibility Antigens Class II / Q000378:metabolism; D006801:Humans; D007774:Lactation / Q000276:immunology / Q000378:metabolism; D015394:Molecular Structure; D011506:Proteins / Q000276:immunology* / Q000378:metabolism; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism
chemical_list: D000955:Antigens, T-Independent; D002241:Carbohydrates; D006017:Glycolipids; D006023:Glycoproteins; D000949:Histocompatibility Antigens Class II; D011506:Proteins