title: Reproducible induction of "atypical" torsades de pointes by programmed electrical stimulation: a novel form of sotalol-induced proarrhythmia?
abstract: We present a patient with sotalol-induced polymorphic ventricular tachycardia that was seen only with programmed ventricular stimulation. Electrophysiologic studies performed prior to initiation of sotalol therapy revealed inducible monomorphic ventricular tachycardia. Possible underlying electrophysiologic mechanisms are discussed.
authors.affiliation: Department of Medicine, Massachusetts General Hospital, Boston 02114, USA.
authors.forename: S C
authors.initials: SC
authors.lastname: Krishnan
authors.forename: J
authors.initials: J
authors.lastname: Galvin
authors.forename: B
authors.initials: B
authors.lastname: McGovern
authors.forename: H
authors.initials: H
authors.lastname: Garan
authors.forename: J N
authors.initials: JN
authors.lastname: Ruskin
mesh_terms: D000889:Anti-Arrhythmia Agents / Q000009:adverse effects* / Q000627:therapeutic use; D002304:Cardiac Pacing, Artificial; D004558:Electric Stimulation; D004562:Electrocardiography; D006801:Humans; D008297:Male; D008875:Middle Aged; D013015:Sotalol / Q000009:adverse effects* / Q000627:therapeutic use; D017180:Tachycardia, Ventricular / Q000139:chemically induced / Q000503:physiopathology; D016171:Torsades de Pointes / Q000139:chemically induced / Q000503:physiopathology*
chemical_list: D000889:Anti-Arrhythmia Agents; D013015:Sotalol