Acute severe depression following peri-operative ondansetron.
A 41-year-old woman with a strong history of postoperative nausea and vomiting presented for abdominal hysterectomy 3 months after a previous anaesthetic where ondansetron prophylaxis had been used. She had developed a severe acute major depression disorder almost immediately thereafter, possibly related to the use of a serotonin antagonist. Nine years before she had experienced a self-limited puerperal depressive episode. Anaesthesia with a propofol infusion and avoidance of serotonin antagonists provided a nausea-free postoperative course without exacerbation of the depression disorder.
Blaine
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D000328:Adult; D003866:Depressive Disorder / Q000139:chemically induced* / Q000188:drug therapy; D005260:Female; D006801:Humans; D009325:Nausea / Q000517:prevention & control; D017294:Ondansetron / Q000009:adverse effects*; D011292:Premedication / Q000009:adverse effects; D012702:Serotonin Antagonists / Q000009:adverse effects*; D014839:Vomiting / Q000517:prevention & control
D012702:Serotonin Antagonists; D017294:Ondansetron