title: Malignant glomus tumor: a case report and review of the literature.
abstract: This report concerns a malignant glomus tumor, a rare soft tissue tumor that was examined immunohistochemically and ultrastructurally. It occurred in a 44-year-old male patient who had suffered from dull pain and stiffness in the right thigh for 10 months. Radiographic examination revealed a well-defined osteolytic lesion in the diaphysis of the right femur. Hypervascularity of the tumor was observed angiographically. Computed tomographic and magnetic resonance examinations showed an intramuscular mass invading the marrow space of the femur. Wide resection was performed after open biopsy. Histologically, round to polygonal tumor cells revealed a uniform appearance of round to ovoid nuclei with single large nucleoli and slightly eosinophilic cytoplasm, forming solid sheets of cells interrupted by vessels of varying size. A few mitotic figures and vascular invasion were observed. Immunohistochemically, vimentin and alpha-smooth muscle actin were stained intensely, and muscle actin was positive for tumor cells of the perivascular area. Tumor cells were negative for desmin, factor VIII-related antigen, S-100 protein, neurofilament, cytokeratin, and epithelial membrane antigen. Ultrastructurally, tumor cells were characterized by many cytoplasmic processes, pinocytotic vesicles, plasmalemmal dense plaques, and scattered microfilaments in the cytoplasm. Few cell junctions and focal basement membrane-like structures were observed. No recurrence or metastasis was noted 57 months after operation. This case was considered to be a malignant glomus tumor, that is, a glomangiosarcoma arising de novo.
authors.affiliation: Department of Pathology, Sakura Hospital, Toho University, Chiba, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Hiruta
authors.forename: N
authors.initials: N
authors.lastname: Kameda
authors.forename: T
authors.initials: T
authors.lastname: Tokudome
authors.forename: K
authors.initials: K
authors.lastname: Tsuchiya
authors.forename: H
authors.initials: H
authors.lastname: Nonaka
authors.forename: T
authors.initials: T
authors.lastname: Hatori
authors.forename: M
authors.initials: M
authors.lastname: Akima
authors.forename: M
authors.initials: M
authors.lastname: Miura
mesh_terms: D000199:Actins / Q000032:analysis; D000328:Adult; D003593:Cytoplasm / Q000648:ultrastructure; D005266:Femoral Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000648:ultrastructure; D005918:Glomus Tumor / Q000737:chemistry / Q000473:pathology* / Q000648:ultrastructure; D006801:Humans; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging; D008297:Male; D008854:Microscopy, Electron; D014841:von Willebrand Factor / Q000032:analysis
chemical_list: D000199:Actins; D014841:von Willebrand Factor