[Lupic spinal cord diseases and antiphospholipid antibodies].
Central nervous system involvement in systemic lupus erythematosus (SLE) is frequent and severe, however, myelopathy is rarely reported (0.8 p. 100 of SLE cases). We describe two SLE-young women. They were 21 and 37 year old, presented with acute paraplegia. CSF study showed pleocytosis and moderately elevated protein. Antinuclear, anti-DNA and anticardiolipin were positive. High dose steroids therapy induced marked improvement. The pathogenesis of myelopathy in SLE remains unclear. Anti-phospholipid antibodies may cause thrombosis and ischemic myelopathy. However, auto-antibodies directed against central nervous system constituents may be involved.
Feki
I
I
Service de Neurologie, Centre Hospitalo-universitaire de Sfax, Tunisie.
Ben Hmida
M
M
Masmoudi
H
H
Triki
C
C
Bahloul
Z
Z
Hachicha
J
J
Jlidi
R
R
Mhiri
C
C
D000328:Adult; D017152:Antibodies, Antiphospholipid / Q000032:analysis* / Q000502:physiology; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000188:drug therapy / Q000276:immunology; D008775:Methylprednisolone / Q000627:therapeutic use; D011241:Prednisone / Q000627:therapeutic use; D011379:Prognosis; D013118:Spinal Cord Diseases / Q000188:drug therapy / Q000209:etiology* / Q000276:immunology
D017152:Antibodies, Antiphospholipid; D005938:Glucocorticoids; D011241:Prednisone; D008775:Methylprednisolone