Disruption of the mouse cyclooxygenase 1 gene. Characteristics of the mutant and areas of future study.
Surprisingly, disruption of the COX-1 gene resulted in generally healthy mice. This is in spite of the fact that prostaglandin levels in the tissues examined were reduced by greater than 99%. The results obtained to date with the COX-1 deficient mice indicate that some of the physiological roles previously attributed to COX-1 may not be entirely correct. Ongoing studies with the COX deficient mice are aimed at better defining the physiological roles of the cyclooxygenases and concomitantly the mechanisms by which NSAIDs cause their biological effects.
Langenbach
R
R
National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA.
Morham
S G
SG
Tiano
H F
HF
Loftin
C D
CD
Ghanayem
B I
BI
Chulada
P C
PC
Mahler
J F
JF
Davis
B J
BJ
Lee
C A
CA
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use / Q000633:toxicity; D002471:Cell Transformation, Neoplastic / Q000187:drug effects / Q000235:genetics; D051545:Cyclooxygenase 1; D016861:Cyclooxygenase Inhibitors / Q000627:therapeutic use / Q000633:toxicity; D005260:Female; D018390:Gene Targeting; D005796:Genes; D005838:Genotype; D007249:Inflammation / Q000188:drug therapy; D007527:Isoenzymes / Q000235:genetics* / Q000502:physiology; D008297:Male; D008565:Membrane Proteins; D051379:Mice / Q000235:genetics*; D018345:Mice, Knockout; D008817:Mice, Mutant Strains; D011451:Prostaglandin-Endoperoxide Synthases / Q000235:genetics* / Q000502:physiology; D012098:Reproduction / Q000502:physiology; D013276:Stomach Ulcer / Q000139:chemically induced
D000894:Anti-Inflammatory Agents, Non-Steroidal; D016861:Cyclooxygenase Inhibitors; D007527:Isoenzymes; D008565:Membrane Proteins; D051545:Cyclooxygenase 1; D011451:Prostaglandin-Endoperoxide Synthases; C496512:Ptgs1 protein, mouse