[Gamma-plant as a new nontoxic interferon inducer].
The interferon-inducing activity of gamma plant was studied in vivo in mice and in vitro in human whole blood cells. The maximum serum interferon (IF) production after intraperitoneal injection of gamma plant was as high as 256 IU/ml. The titers of IF produced in response to gamma plant were 16 to 32 times higher than the level of IF induced by gossipol. The capacity of human whole blood cells to produce IF under the effects of various doses of different inducers (Newcastle disease virus, staphylococcal enterotoxin A, gossipol, and gamma plant) was studied in vitro. In contrast to gossipol and staphylococcal enterotoxin A, gamma plant stimulated the cell production of IF with a high antiviral effect in culture medium. The findings permit a conclusion on a high potency of gamma plant as an IF inducer.
Chekanovskaia
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D000818:Animals; D002478:Cells, Cultured; D003470:Culture Media; D004305:Dose-Response Relationship, Drug; D005936:Glucans / Q000494:pharmacology* / Q000633:toxicity; D006801:Humans; D007369:Interferon Inducers / Q000494:pharmacology*; D051379:Mice; D008808:Mice, Inbred CBA
D003470:Culture Media; D005936:Glucans; D007369:Interferon Inducers