title: Phosphorylation and desensitization of the pancreatic cholecystokinin-A receptor.
abstract: The eukaryotic cell uses a variety of mechanisms to protect itself from overstimulation. Among these mechanisms are processes involving the receptor, including uncoupling from G proteins and movement into cellular compartments. Here, we focus on mechanisms by which the pancreatic acinar cell protects itself from overstimulation through the cholecystokinin receptor with special emphasis on the role of receptor phosphorylation.
authors.affiliation: Department of Biochemistry, University of Nijmegen, The Netherlands. P.Willems@bioch.kun.nl
authors.forename: P H
authors.initials: PH
authors.lastname: Willems
authors.forename: R L
authors.initials: RL
authors.lastname: Smeets
authors.forename: R R
authors.initials: RR
authors.lastname: Bosch
authors.forename: J J
authors.initials: JJ
authors.lastname: De Pont
mesh_terms: D000818:Animals; D002766:Cholecystokinin / Q000494:pharmacology; D004798:Enzymes / Q000378:metabolism; D006801:Humans; D010179:Pancreas / Q000166:cytology / Q000378:metabolism*; D010766:Phosphorylation; D011493:Protein Kinase C / Q000037:antagonists & inhibitors; D043886:Receptor, Cholecystokinin A; D011949:Receptors, Cholecystokinin / Q000378:metabolism* / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology
chemical_list: D004798:Enzymes; D043886:Receptor, Cholecystokinin A; D011949:Receptors, Cholecystokinin; D002766:Cholecystokinin; D011493:Protein Kinase C