[Development and study of properties of immunoglobulins against Lassa fever].
A horse may serve the producer of immune antiserum to Lassa virus. Specific immunoglobulin with at least 1:512 titer of virus-neutralizing antibodies to Lassa fever was obtained by alcohol sedimentation after Cohn from the blood serum of immunized horses. The preparation does not differ from heterologous commercial immunoglobulins. Preclinical studies of immunoglobulin to Lassa fever demonstrated its safety and a high specific activity. The agent can be injected both alone and in combination with virasole.
Krasnianskiĭ
V P
VP
Gradoboev
V N
VN
Borisevich
I V
IV
Potryvaeva
N V
NV
Lebedinskaia
E V
EV
Chernikova
N K
NK
Timan'kova
G D
GD
D000818:Animals; D006736:Horses; D007106:Immune Sera; D007136:Immunoglobulins / Q000096:biosynthesis*; D007835:Lassa Fever / Q000188:drug therapy / Q000517:prevention & control*; D007836:Lassa virus / Q000276:immunology*; D009500:Neutralization Tests; D012254:Ribavirin / Q000627:therapeutic use; D014765:Viral Vaccines / Q000627:therapeutic use
D007106:Immune Sera; D007136:Immunoglobulins; D014765:Viral Vaccines; D012254:Ribavirin