[Molecular characterization of platelet-specific alloantigens].
Platelet-specific alloantigens have been implicated in the pathogenesis of immune mediated diseases such as neonatal alloimmune thrombocytopenic purpura, post-transfusion purpura and platelet transfusion refractoriness. Recently, it has been paid attention in terms of an inherited risk factor for coronary thrombosis. Because all the established polymorphisms are located on important receptors for adhesive molecules, including integrins alpha 2 beta 1 and alpha IIb beta 3 and GPIb alpha, effects of these polymorphisms on function of the receptors have been studied. In this review, recent studies on molecular characterization of these polymorphisms will be described.
Furihata
K
K
Department of Laboratory Medicine, Shinshu University School of Medicine.
D016824:Antigens, Human Platelet / Q000235:genetics*; D006801:Humans; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000276:immunology; D011110:Polymorphism, Genetic
D016824:Antigens, Human Platelet; D019039:Platelet Glycoprotein GPIIb-IIIa Complex