Ultrasonic activated drug delivery from Pluronic P-105 micelles.
Pluronic copolymer P-105 at micellar concentration of 10 wt% was found to increase the activity of the anti-cancer drug, doxorubicin (DOX) against HL-60 cells. Despite the enhanced activity, drug uptake by the cells from P-105 micelles (measured by fluorescence) was found to be much lower than that from a molecular solution of DOX (without the surfactant). Ultrasound (US) was applied as a tool to release drug from the micelles. Based on the combination of ultrasound and micellar treatment, doxorubicin exhibited IC50 concentrations of 2.35, 0.9, 1.25, 0.19 microg/ml with respect to DOX, DOX/US, micellar DOX, and micellar DOX/US, respectively. The results suggest that by encapsulating the anti-cancer drug in micellar carriers and focussing ultrasound on the tumor site, a new approach to drug targetting can be developed.
Munshi
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Department of Chemical Engineering, Brigham Young University, Provo, UT 84602, USA.
Rapoport
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N
Pitt
W G
WG
D001692:Biological Transport; D002470:Cell Survival / Q000187:drug effects; D004317:Doxorubicin / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000633:toxicity*; D004337:Drug Carriers; D018922:HL-60 Cells; D006801:Humans; D007700:Kinetics; D008823:Micelles; D014465:Ultrasonics
D004337:Drug Carriers; D008823:Micelles; D004317:Doxorubicin