title: Idiopathic myelofibrosis with neutrophil myeloperoxidase deficiency: a case report.
abstract: We describe a case of idiopathic myelofibrosis with total neutrophil myeloperoxidase deficiency. The combination of this enzymatic defect with myelofibrotic changes in the nuclear shape of neutrophils confers a peculiar appearance on leukograms produced by a Technicon H*1. The clinical course of the disease was shortened by recurrent infections that may be ascribed, at least in part, to reduced leukocyte microbicidal ability.
authors.affiliation: Chair of Internal Medicine, University of Padua, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Caenazzo
authors.forename: E
authors.initials: E
authors.lastname: Piva
authors.forename: D
authors.initials: D
authors.lastname: Sartori
authors.forename: P M
authors.initials: PM
authors.lastname: Stefani
mesh_terms: D001853:Bone Marrow / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000201:enzymology* / Q000473:pathology; D009195:Peroxidase / Q000172:deficiency*; D055728:Primary Myelofibrosis / Q000097:blood / Q000201:enzymology* / Q000473:pathology / Q000503:physiopathology
chemical_list: D009195:Peroxidase