title: Family with Graves disease, multinodular goiter, nonmedullary thyroid carcinoma, and alveolar rhabdomyosarcoma.
abstract: Benign thyroid disease is a risk factor for nonmedullary thyroid carcinoma [Houlston and Stratton: Q J Med 88:685-693, 1995]. We report on a family with 7 members with benign and/or malignant thyroid neoplasia; one affected female died of a paravertebral alveolar rhabdomyosarcoma at age 20. The occurrence of thyroid nodular hyperplasia, nonmedullary thyroid cancer, and rhabdomyosarcoma in the same family may be due to chance, common environmental factors, or, most likely, genetic predisposition.
authors.affiliation: Department of Human Genetics, McGill University, Montreal, Quebec, Canada.
authors.forename: H A
authors.initials: HA
authors.lastname: Druker
authors.forename: L
authors.initials: L
authors.lastname: Kasprzak
authors.forename: L R
authors.initials: LR
authors.lastname: Bégin
authors.forename: S
authors.initials: S
authors.lastname: Jothy
authors.forename: S A
authors.initials: SA
authors.lastname: Narod
authors.forename: W D
authors.initials: WD
authors.lastname: Foulkes
mesh_terms: D000293:Adolescent; D002648:Child; D005260:Female; D006042:Goiter / Q000235:genetics; D006111:Graves Disease / Q000235:genetics; D006801:Humans; D008297:Male; D019042:Muscle Neoplasms / Q000235:genetics; D010375:Pedigree; D018232:Rhabdomyosarcoma, Alveolar / Q000235:genetics; D012307:Risk Factors; D013945:Thymoma / Q000235:genetics; D013959:Thyroid Diseases / Q000235:genetics; D013964:Thyroid Neoplasms / Q000235:genetics