title: Decision-making about genetic testing among women at familial risk for breast cancer.
abstract: OBJECTIVE
  Recent identification of the breast-ovarian cancer susceptibility gene BRCA1 and the breast cancer susceptibility gene BRCA2 have raised the possibility of clinical genetic testing for breast cancer susceptibility. This study examined decision-making about future susceptibility testing among women at familial risk for breast cancer. Based on the transtheoretical model, it was hypothesized that readiness to undergo testing would be related to the ratio between the perceived advantages (pros) and disadvantages (cons) of learning one's susceptibility status.
  
  
  METHODS
  Seventy-four women with one or more first-degree relatives with breast cancer were recruited before a routine mammogram. Participants completed measures assessing readiness to undergo testing, perceived pros and cons of testing, and perceived breast cancer risk. Family history data was used to calculate empiric genetic risk of developing breast cancer.
  
  
  RESULTS
  Forty-six per cent of participants planned to seek genetic testing as soon as possible, 35% planned to seek testing in the future, and 19% did not plan to seek testing. As expected, greater readiness to undergo testing was associated with a positive decisional balance (pros > cons). Older age and greater perceived risk (but not empiric risk) also were associated with greater readiness.
  
  
  CONCLUSIONS
  The readiness of many women to seek breast cancer susceptibility testing can be attributed, in large part, to their perceptions that the advantages outweigh the disadvantages. Examination of these perceptions suggests that notification of carrier status may have significant effects on women's psychological well-being and breast cancer surveillance and prevention behaviors.
authors.affiliation: Department of Psychology, University of South Florida, Tampa 33620, USA.
authors.forename: P B
authors.initials: PB
authors.lastname: Jacobsen
authors.forename: H B
authors.initials: HB
authors.lastname: Valdimarsdottier
authors.forename: K L
authors.initials: KL
authors.lastname: Brown
authors.forename: K
authors.initials: K
authors.lastname: Offit
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001294:Attitude to Health; D001943:Breast Neoplasms / Q000235:genetics / Q000517:prevention & control* / Q000523:psychology; D016009:Chi-Square Distribution; D003430:Cross-Sectional Studies; D003657:Decision Making; D004198:Disease Susceptibility; D005192:Family Health; D005260:Female; D005820:Genetic Testing / Q000523:psychology*; D006801:Humans; D016015:Logistic Models; D008875:Middle Aged; D018570:Risk Assessment; D012494:Sampling Studies