title: [APC, beta-catenin, DLG].
abstract: The APC gene is mutated in the majority of colorectal tumors. The product of this gene is a 300 kDa protein associated with beta-catenin and the human homolog of the Drosophila tumor suppressor DLG. The study of the function of APC provides important insights into the mechanisms of the development of colorectal tumor.
authors.affiliation: Dept. of Oncogene Research, Osaka University.
authors.forename: T
authors.initials: T
authors.lastname: Akiyama
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D011125:Adenomatous Polyposis Coli / Q000235:genetics*; D025601:Adenomatous Polyposis Coli Protein; D000818:Animals; D002453:Cell Cycle; D002895:Chromosomes, Human, Pair 5; D003598:Cytoskeletal Proteins / Q000737:chemistry* / Q000502:physiology*; D000074288:Discs Large Homolog 1 Protein; D051528:Guanylate Kinases; D006801:Humans; D008565:Membrane Proteins; D051379:Mice; D011506:Proteins / Q000737:chemistry / Q000502:physiology*; D015534:Trans-Activators; D051176:beta Catenin
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D025601:Adenomatous Polyposis Coli Protein; C495270:CTNNB1 protein, human; C495267:CTNNB1 protein, mouse; D003598:Cytoskeletal Proteins; C513314:DLG1 protein, human; D000074288:Discs Large Homolog 1 Protein; C000614189:Dlg1 protein, mouse; D008565:Membrane Proteins; D011506:Proteins; D015534:Trans-Activators; D051176:beta Catenin; D051528:Guanylate Kinases