Ablation of interleukin-12 exacerbates Lyme arthritis in SCID mice.
The administration of interleukin-12 (IL-12) antibodies to Borrelia burgdorferi-infected C3H/HeN-scid mice increased the severity of acute Lyme arthritis. These results contrasted with the reduction of Lyme arthritis by IL-12 antibodies in immunocompetent animals. These data suggest that downregulation of innate immunity in SCID mice in the absence of B- and T-cell responses leads to an exacerbation of joint inflammation.
Anguita
J
J
Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520-8031, USA.
Samanta
S
S
Barthold
S W
SW
Fikrig
E
E
D000818:Animals; D000906:Antibodies / Q000494:pharmacology; D016918:Arthritis, Reactive / Q000276:immunology* / Q000473:pathology; D004195:Disease Models, Animal; D018664:Interleukin-12 / Q000172:deficiency / Q000276:immunology*; D008193:Lyme Disease / Q000276:immunology* / Q000473:pathology; D051379:Mice; D008809:Mice, Inbred C3H; D016513:Mice, SCID; D013640:Tarsal Joints / Q000473:pathology
D000906:Antibodies; D018664:Interleukin-12