[Correlation between the tumor marker Pro-GRP and prognosis in patients with small-cell lung cancer].
We studied 90 patients with small-cell lung cancer in whom levels of Pro-GRP were abnormally high before therapy. Changes in the serum Pro-GRP level have been said to correlate strongly with therapeutic responses in patients with small-cell lung cancer. We found that changes in the serum Pro-GRP level (half-life > or = 30 vs < 30 days) were a significant prognostic factor. Multivariate analysis showed that in these patients the Pro-GRP level after therapy, Performance Status, and age were independent prognostic factors.
Tsuchiyama
T
T
Department of Internal Medicine, National Kinki Central Hospital for Chest Diseases, Osaka, Japan.
Kawahara
M
M
Naka
N
N
Yamamoto
S
S
Nakao
M
M
Kamimori
T
T
Okada
T
T
Atagi
S
S
Ogawara
M
M
Furuse
K
K
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000097:blood*; D018288:Carcinoma, Small Cell / Q000097:blood* / Q000401:mortality / Q000628:therapy; D005260:Female; D019886:Gastrin-Releasing Peptide / Q000097:blood*; D006801:Humans; D008175:Lung Neoplasms / Q000097:blood* / Q000401:mortality / Q000628:therapy; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D015996:Survival Rate
D014408:Biomarkers, Tumor; D019886:Gastrin-Releasing Peptide