title: Effect of xylitol in an enzyme-containing dentifrice without sodium lauryl sulfate on mutans streptococci in vivo.
abstract: The aim of this investigation was to compare the effect of an enzyme-containing dentifrice without sodium lauryl sulfate but with addition of xylitol (Zendium Dentine) on mutans streptococci (MS) in saliva and dental plaque with that of the same dentifrice without xylitol. The subjects were divided into a test group, using a dentifrice with 10% xylitol (part A) or 5% xylitol (part B), and a control group, using a dentifrice without xylitol, for 3 months. In part A the MS counts in saliva and plaque were significantly lower in the xylitol group (n = 50) than in the control group (n = 57) (P < 0.01 and P < 0.001, respectively). In part B (n = 89 + 91), evaluating MS counts in saliva only, no significant difference was found. Thus, this study demonstrated I) that addition of 10% xylitol to an enzyme-containing dentifrice without sodium lauryl sulfate has an inhibitory effect on MS counts in saliva and dental plaque, and 2) that the inhibitory effect seems to be dose-dependent.
authors.affiliation: School of Dental Hygiene, Kristianstad University College of Health Sciences, Sweden.
authors.forename: L
authors.initials: L
authors.lastname: Jannesson
authors.forename: S
authors.initials: S
authors.lastname: Renvert
authors.forename: D
authors.initials: D
authors.lastname: Birkhed
mesh_terms: D000328:Adult; D002327:Cariostatic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D016022:Case-Control Studies; D015169:Colony Count, Microbial; D003773:Dental Plaque / Q000382:microbiology; D003802:Dentifrices / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D005500:Follow-Up Studies; D005087:Glucan 1,4-alpha-Glucosidase / Q000627:therapeutic use*; D005949:Glucose Oxidase / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D012463:Saliva / Q000382:microbiology; D012967:Sodium Dodecyl Sulfate; D013295:Streptococcus mutans / Q000187:drug effects* / Q000254:growth & development; D013501:Surface-Active Agents; D014993:Xylitol / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D002327:Cariostatic Agents; D003802:Dentifrices; D013501:Surface-Active Agents; D012967:Sodium Dodecyl Sulfate; D005949:Glucose Oxidase; D005087:Glucan 1,4-alpha-Glucosidase; D014993:Xylitol