title: [Effects of PDGF AB on extracellular matrix synthesis by human mammary fibroblasts].
abstract: PDGF AB effect on extracellular matrix protein synthesis and release by a primary culture of non transformed human mammary fibroblasts was analyzed. Primarily PDGF AB induced a modified protein distribution, with a global enhancement of secreted proteins as compared to intracytoplasmatic proteins. Furthermore, an increase in synthesis and release of the extracellular matrix proteins such as fibronectin and type I and IV collagens upon PDGF AB treatment with specific immunoprecipitation was demonstrated.
authors.affiliation: Dipartimento di Medicina Sperimentale e Patologia, Università degli Studi La Sapienza, Roma.
authors.forename: C
authors.initials: C
authors.lastname: Palumbo
authors.forename: F
authors.initials: F
authors.lastname: Vasaturo
authors.forename: G
authors.initials: G
authors.lastname: Zelli
authors.forename: P
authors.initials: P
authors.lastname: Cardelli
authors.forename: G
authors.initials: G
authors.lastname: Rubinacci
authors.forename: M
authors.initials: M
authors.lastname: Modesti
authors.forename: S
authors.initials: S
authors.lastname: Scarpa
mesh_terms: D000368:Aged; D001345:Autoradiography; D001943:Breast Neoplasms / Q000378:metabolism / Q000473:pathology*; D016326:Extracellular Matrix Proteins / Q000096:biosynthesis* / Q000187:drug effects; D005260:Female; D005319:Fetal Hemoglobin / Q000378:metabolism*; D018226:Fibroadenoma / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D066298:In Vitro Techniques; D010982:Platelet-Derived Growth Factor / Q000494:pharmacology*; D011233:Precipitin Tests
chemical_list: D016326:Extracellular Matrix Proteins; D010982:Platelet-Derived Growth Factor; D005319:Fetal Hemoglobin