How Salmonella became a pathogen.
In many pathogens, virulence can be conferred by a single region of the genome. In contrast, the facultative intracellular lifestyle of Salmonella demands a large number of genes distributed around the chromosome. The evolution of Salmonella has been marked by the acquisition of several 'pathogenicity islands', each contributing to the unique virulence properties of this microorganism.
Groisman
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Dept of Molecular Microbiology, Howard Hughes Medical Institute, Washington University School of Medicine, St Louis, MO 63110-1093, USA. groisman@borcim.wustl.edu
Ochman
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D002874:Chromosome Mapping; D015964:Gene Expression Regulation, Bacterial; D005798:Genes, Bacterial / Q000502:physiology*; D006090:Gram-Negative Bacteria / Q000235:genetics; D006790:Host-Parasite Interactions / Q000502:physiology; D010802:Phylogeny; D012475:Salmonella / Q000235:genetics / Q000472:pathogenicity* / Q000648:ultrastructure; D014774:Virulence / Q000235:genetics*