[Evaluation of the hypophyseal-hypothalamo-adrenal axis in patients undergoing chronic corticotherapy at suppressive doses].
A cortisol curve was practiced on 32 healthy persons with an average age of 38.7 years, being the morning amount at 8 o'clock of 10 mg/100 ml o higher. Later we practiced the same study in 42 patients with an average age of 41.4 years, that were under a corticosteroid therapy higher than 10 mg per day of prednisone during more than three months of an uninterrupted prescription and said treatment was stopped 48 previous hours to the study. We found that 27 of them (64.2%) had lowe morning amount of cortisol to those of the control group, and the patients with rheumatoid arthritis being the lowest. It is concluded that the type of systemic disease could be another factor in the suppression of the axis H-H-A of patients under a higher dosis than 10 mg of prednisone and a durability longer than three continuous months.
Gálvez Gudiño
V J
VJ
Hospital del ISSSTE, San Luis Potosi, SLP, México, DF.
D000324:Adrenocorticotropic Hormone; D000328:Adult; D001327:Autoimmune Diseases / Q000097:blood / Q000188:drug therapy; D002940:Circadian Rhythm; D003864:Depression, Chemical; D005260:Female; D006801:Humans; D006849:Hydrocephalus / Q000097:blood / Q000188:drug therapy; D006854:Hydrocortisone / Q000097:blood / Q000378:metabolism*; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D010913:Pituitary-Adrenal System / Q000187:drug effects* / Q000378:metabolism; D011241:Prednisone / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D012120:Respiration Disorders / Q000097:blood / Q000188:drug therapy
D000324:Adrenocorticotropic Hormone; D011241:Prednisone; D006854:Hydrocortisone