Outcome studies in adequacy of dialysis.
The theoretical constructs indicate that for a 70-kg high transport anephric patient, adequate dialysis requires a weekly Kt/V of 2.0-2.25. The prospective cohort studies, with one exception, suggest that better survival requires a weekly Kt/V > 1.89. Multivariate analyses confirm the statistical association of patient survival with higher Kt/V and with higher CCr. The use of initial values in one study, mean values in two studies, and time-dependent values in another makes comparison difficult. In general, higher values are associated with better survival and are consistent with the values suggested by theoretical constructs (i.e., Kt/V 2.0-2.25).
Churchill
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DN
St. Joseph's Hospital-McMaster University, Hamilton, Ontario, Canada.
D001835:Body Weight; D015331:Cohort Studies; D003404:Creatinine / Q000378:metabolism; D006801:Humans; D007676:Kidney Failure, Chronic / Q000628:therapy; D015999:Multivariate Analysis; D010531:Peritoneal Dialysis, Continuous Ambulatory / Q000379:methods*; D011446:Prospective Studies; D015996:Survival Rate; D013997:Time Factors; D016896:Treatment Outcome; D014508:Urea / Q000378:metabolism
D014508:Urea; D003404:Creatinine