[Angiogenesis and its inhibitors].
Angiogenesis is controlled by a local balance between stimulators and inhibitors of growth of new vessels. Aberrant angiogenesis is closely involved in invasion/metastasis as well as malignant tumors. There are several strategies for inhibiting tumor angiogenesis. In this article, we investigator whether endogenous angiogenesis inhibitors, plasminogen activator and matrix metalloprotease inhibitors and Flk-1 antagonists could be anti-angiogenesis targets of intrinsic interest.
Ono
M
M
Dept. of Biochemistry, Kyushu University School of Medicine.
Kuwano
M
M
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D003094:Collagen / Q000494:pharmacology; D043169:Endostatins; D004730:Endothelium, Vascular / Q000187:drug effects; D006131:Growth Inhibitors / Q000494:pharmacology*; D006801:Humans; D008666:Metalloendopeptidases / Q000037:antagonists & inhibitors; D051379:Mice; D009369:Neoplasms / Q000098:blood supply* / Q000201:enzymology / Q000473:pathology; D009389:Neovascularization, Pathologic / Q000188:drug therapy*; D010446:Peptide Fragments / Q000494:pharmacology; D011480:Protease Inhibitors / Q000494:pharmacology; D014227:Triazines / Q000494:pharmacology; D014315:Triterpenes / Q000494:pharmacology
D000970:Antineoplastic Agents; D043169:Endostatins; D006131:Growth Inhibitors; D010446:Peptide Fragments; D011480:Protease Inhibitors; D014227:Triazines; D014315:Triterpenes; C099855:demethylzeylasteral; D003094:Collagen; D008666:Metalloendopeptidases; C041836:irsogladine