title: [Pseudotumor form of hepatic distomatosis: successful treatment with praziquantel].
abstract: Human Fasciola hepatica infection is usually discovered either early, during the acute (invasive) phase, or in the advanced phase, which is characterized by biliary complications. We report a case of liver distomatosis with nodular intra-hepatic lesions in a 58-year-old woman. Radiological investigations showed 3 nodular lesions in the VII segment, which were difficult to distinguish from liver metastases or liver abscesses. Distomatosis serology was positive with passive hemagglutination. After a 5-day treatment with praziquantel, clinical symptoms resolved quickly while serological tests became negative. Radiological images slowly decreased to a calcified scar at 13 months. No side-effects were noted. Praziquantel, whose efficacy in the common presentations of liver distomatosis has recently been demonstrated, also seems effective and well tolerated in case of nodular intra-hepatic lesions.
authors.affiliation: Service de Gastroentérologie, CHRU Jean Minjoz, Besançon.
authors.forename: P E
authors.initials: PE
authors.lastname: Queneau
authors.forename: S
authors.initials: S
authors.lastname: Koch
authors.forename: S
authors.initials: S
authors.lastname: Bresson-Hadni
authors.forename: B
authors.initials: B
authors.lastname: Bartholomot
authors.forename: F
authors.initials: F
authors.lastname: Arbez-Gindre
authors.forename: B
authors.initials: B
authors.lastname: Heyd
authors.forename: J P
authors.initials: JP
authors.lastname: Miguet
mesh_terms: D000980:Antiplatyhelmintic Agents / Q000627:therapeutic use*; D003937:Diagnosis, Differential; D005211:Fascioliasis / Q000175:diagnosis / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008109:Liver Diseases, Parasitic / Q000175:diagnosis; D008113:Liver Neoplasms / Q000175:diagnosis; D008875:Middle Aged; D011223:Praziquantel / Q000627:therapeutic use*
chemical_list: D000980:Antiplatyhelmintic Agents; D011223:Praziquantel