title: A prospective evaluation of catheter ablation of ventricular tachycardia as adjuvant therapy in patients with coronary artery disease and an implantable cardioverter-defibrillator.
abstract: BACKGROUND
  Implantable cardioverter-defibrillator (ICD) therapy is integral to current therapy for ventricular tachycardia. Patients with an ICD frequently require concomitant antiarrhythmic drug therapy. Despite this, some patients still receive frequent ICD therapies for ventricular tachycardia. Therefore, the purpose of this prospective study was to determine the utility of ablation of ventricular tachycardia in patients with an ICD who experience frequent ICD therapies.
  
  
  RESULTS
  Twenty-one consecutive patients with frequent ICD therapies despite antiarrhythmic drug therapy were the subjects of this study. The mean age was 69+/-6 years, and 17 were men. The mean ejection fraction was 0.22+/-0.08, and all patients had coronary artery disease. During the 36+/-51 days (range, 4 days to 7 months) preceding the ablation procedures, the patients received 34+/-55 ICD therapies for the clinical ventricular tachycardia, or a mean of 25+/-88 ICD therapies per month. The patients underwent radiofrequency ablation of the presumed clinical ventricular tachycardia by inducing the tachycardia and mapping according to endocardial activation, continuous electrical activity, pace mapping, concealed entrainment, or mid-diastolic potentials. Ablation of the clinical arrhythmia was successful in 76% of patients during 1.4+/-0.6 (range, 1 to 3) ablation procedures and required 12.5+/-9.2 applications of energy. During 11.8+/-10.0 months of follow-up, the frequency of ICD therapies per month decreased from 60+/-80 before successful ablation to 0.1+/-0.3 ICD therapies per month after ablation (P=.01). A quality-of-life assessment demonstrated a significant improvement after successful (P=.02) but not unsuccessful ablation (P=.9).
  
  
  CONCLUSIONS
  Radiofrequency ablation of ventricular tachycardia as adjuvant therapy in patients with coronary artery disease and an ICD has a reasonable success rate, significantly reduces ICD therapies, and appears to be associated with an improved quality of life.
authors.affiliation: Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor 48109-0022, USA.
authors.forename: S A
authors.initials: SA
authors.lastname: Strickberger
authors.forename: K C
authors.initials: KC
authors.lastname: Man
authors.forename: E G
authors.initials: EG
authors.lastname: Daoud
authors.forename: R
authors.initials: R
authors.lastname: Goyal
authors.forename: K
authors.initials: K
authors.lastname: Brinkman
authors.forename: C
authors.initials: C
authors.lastname: Hasse
authors.forename: F
authors.initials: F
authors.lastname: Bogun
authors.forename: B P
authors.initials: BP
authors.lastname: Knight
authors.forename: R
authors.initials: R
authors.lastname: Weiss
authors.forename: M
authors.initials: M
authors.lastname: Bahu
authors.forename: F
authors.initials: F
authors.lastname: Morady
mesh_terms: D000368:Aged; D002304:Cardiac Pacing, Artificial; D017115:Catheter Ablation; D015331:Cohort Studies; D003327:Coronary Disease / Q000601:surgery*; D017147:Defibrillators, Implantable; D005069:Evaluation Studies as Topic; D005260:Female; D005500:Follow-Up Studies; D005544:Forecasting; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011788:Quality of Life; D019233:Retreatment; D017180:Tachycardia, Ventricular / Q000503:physiopathology / Q000601:surgery*; D016896:Treatment Outcome