title: Renal artery repair in African-Americans.
abstract: OBJECTIVE
  This retrospective review examines the results of atherosclerotic renal artery (RA) repair in consecutive hypertensive African-Americans treated at our center and compares these results with Caucasians treated during the same period.
  
  
  METHODS
  From Jan. 1987 through Sep. 1996, a total of 485 patients underwent operative RA repair. Of these, 28 African-Americans and 370 Caucasians were managed for atherosclerotic renovascular disease. These cohorts were compared on the basis of preoperative blood pressure and renal function, extent of renal disease, extrarenal atherosclerosis, response to operation, and estimated survival.
  
  
  RESULTS
  The African-American cohort included nine men and 19 women (mean age, 62 years) with hypertension (mean blood pressure, 204 +/- 31/109 +/- 20 mm Hg) for an average of 10.2 +/- 7.5 years. Ischemic nephropathy (serum creatinine level, > 1.3 mg/dl) was present in 82% (n = 23) of the African-American group. RA reconstructions were unilateral in nine patients and bilateral in 19 patients (including repair to two solitary kidneys), for a total of 45 RA reconstructions (30 RA bypass procedures; eight transrenal/transaortic RA endarterectomy procedures; two RA reimplantations; five nephrectomies). Nine patients underwent combined aortic procedures (four abdominal aortic aneurysm; five occlusive disease). There was one perioperative death in the African-American group as a result of sepsis and multiple organ failure. Among surgical survivors, 20 African-American patients (74%) had a beneficial hypertension response (7% cured, 67% improved). Mean estimated glomerular filtration rate improved significantly from 34 to 42 ml/min/1.73 m2 (p < 0.001). In the 23 patients with ischemic nephropathy, 13 (57%) demonstrated greater than 20% decrease in serum creatinine level. In comparison with the 370 Caucasians (191 men, 179 women), the African-American cohort had significantly more preoperative heart disease (congestive heart failure or left ventricular hypertrophy; 68% vs 46%; p = 0.03) and tended toward more severe renal dysfunction (mean serum creatinine level, 2.5 vs 2.1 mg/dl; p = 0.25). However, African-Americans demonstrated a beneficial blood pressure and renal function response after operation, similar to Caucasians.
  
  
  CONCLUSIONS
  Our results indicate that the majority of selected African-Americans have a favorable blood pressure and renal function response to operative renal artery repair. This beneficial clinical response appears equivalent to the response observed in Caucasian patients and supports the search for RA disease in hypertensive African-Americans.
authors.affiliation: Department of General Surgery, Wake Forest University Medical Center, Winston-Salem, North Carolina 27157-1095, USA.
authors.forename: J S
authors.initials: JS
authors.lastname: Deitch
authors.forename: K J
authors.initials: KJ
authors.lastname: Hansen
authors.forename: T E
authors.initials: TE
authors.lastname: Craven
authors.forename: J M
authors.initials: JM
authors.lastname: Flack
authors.forename: R G
authors.initials: RG
authors.lastname: Appel
authors.forename: R H
authors.initials: RH
authors.lastname: Dean
mesh_terms: D000328:Adult; D000368:Aged; D001161:Arteriosclerosis / Q000175:diagnosis / Q000208:ethnology / Q000503:physiopathology / Q000601:surgery; D044383:Black People; D001794:Blood Pressure; D002908:Chronic Disease; D015331:Cohort Studies; D005260:Female; D006801:Humans; D006978:Hypertension, Renovascular / Q000175:diagnosis / Q000208:ethnology / Q000503:physiopathology / Q000601:surgery; D007668:Kidney / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009657:North Carolina / Q000453:epidemiology; D011184:Postoperative Period; D012077:Renal Artery / Q000503:physiopathology / Q000601:surgery*; D012078:Renal Artery Obstruction / Q000175:diagnosis / Q000208:ethnology / Q000503:physiopathology / Q000601:surgery; D012189:Retrospective Studies; D044465:White People; D001741:Black or African American