Anxiety and depressive symptoms in childhood--a genetic study of comorbidity.
Anxiety and depressive symptoms commonly co-occur yet the underlying mechanisms for this covariation remain poorly understood. Genetic strategies are a useful means of investigating whether the comorbidity of two sets of symptoms or disorders can be explained by the same aetiological factors. In this paper we use a systematically ascertained sample of 172 twin pairs aged 8 to 16 years to examine the causes of covariation of maternally rated anxiety and depressive symptoms. The results suggest that most of the covariation can be explained by a common set of genes that influence anxiety and depressive symptoms. Some covariation between anxiety and depressive symptoms is also explained by environmental influences of the non-shared type. In addition, depressive symptoms also appear to be influenced by specific genetic factors.
Thapar
A
A
University of Manchester, Royal Manchester Children's Hospital, U.K.
McGuffin
P
P
D000293:Adolescent; D001008:Anxiety Disorders / Q000175:diagnosis / Q000235:genetics* / Q000523:psychology; D002648:Child; D015897:Comorbidity; D003866:Depressive Disorder / Q000175:diagnosis / Q000235:genetics* / Q000523:psychology; D004200:Diseases in Twins / Q000235:genetics* / Q000523:psychology; D005260:Female; D006801:Humans; D008297:Male; D008957:Models, Genetic; D010552:Personality Assessment; D012307:Risk Factors; D014429:Twins, Dizygotic / Q000235:genetics / Q000523:psychology; D014430:Twins, Monozygotic / Q000235:genetics / Q000523:psychology; D014852:Wales