Effects of acute administration of transdermal estrogen on postmenopausal women with systemic hypertension.
We studied 16 postmenopausal women with mild to moderate hypertension according to a randomized, double-blind protocol. They received patches of transdermal estradiol-17beta rated to deliver 100 mg/day of substance or matched placebo. A 24-hour ambulatory blood pressure (BP) monitoring was performed at baseline and after drug administrations. Our data show that estradiol-17beta exerts beneficial effects, both in lowering elevated BP levels and in maintaining a uniform BP control over 24 hours. Estrogen replacement therapy could be considered when significant changes in BP occur during the postmenopausal period.
Mercuro
G
G
The Institute of Cardiology, and Department of Obstetrics and Gynaecology, University of Cagliari, Sardinia, Italy.
Zoncu
S
S
Pilia
I
I
Lao
A
A
Melis
G B
GB
Cherchi
A
A
D000279:Administration, Cutaneous; D001794:Blood Pressure / Q000187:drug effects*; D001795:Blood Pressure Determination; D018592:Cross-Over Studies; D004311:Double-Blind Method; D004958:Estradiol / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000503:physiopathology; D008875:Middle Aged; D017698:Postmenopause
D004958:Estradiol