title: In-vivo and in-vitro sensitivity of Plasmodium falciparum to chloroquine in Chennai (Tamil Nadu), India.
abstract: In-vitro and in-vivo susceptibility of Plasmodium falciparum to chloroquine were conducted at Chennai city, India. Eighteen (60%) out of 30 cases showed resistance in in-vitro study. EC50 of resistant and sensitive cases were 0.40 and 0.24 mumol chloroquine/l blood respectively, while EC90 were 2.64 and 0.84 mumol chloroquine/l blood respectively. In-vivo tests identified 24 cases (40%) as resistant (23 RI and 1 RII) and 36 (60%) as sensitive out of 60 cases. Eight isolates which were found resistant with in-vitro tests showed sensitive behaviour to chloroquine treatment assessed by in-vivo studies.
authors.affiliation: Malaria Research Centre (Field Station), Sector III, Ranipur, Hardwar, India.
authors.forename: V K
authors.initials: VK
authors.lastname: Dua
authors.forename: P K
authors.initials: PK
authors.lastname: Kar
authors.forename: N C
authors.initials: NC
authors.lastname: Gupta
authors.forename: I
authors.initials: I
authors.lastname: Kar
authors.forename: V P
authors.initials: VP
authors.lastname: Sharma
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D002738:Chloroquine / Q000494:pharmacology*; D005260:Female; D006801:Humans; D016778:Malaria, Falciparum / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D010963:Plasmodium falciparum / Q000187:drug effects*
chemical_list: D000962:Antimalarials; D002738:Chloroquine