Genetic analysis of the role of Eph receptors in the development of the mammalian nervous system.
The Eph family of tyrosine protein kinase receptors and their cognate ligands, a family of membrane-bound molecules known as ephrins, have been implicated in diverse biological processes, such as axon guidance, the formation of topographic neural projections, axon fasciculation, the regionalization of the central nervous system, and cell migration. The recent generation of mutant mice lacking some of these receptors has made possible the dissection of the role that these molecules play in the development of the mammalian nervous system.
Frisén
J
J
Department of Molecular Oncology, Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, NJ 08543-4000, USA.
Barbacid
M
M
D000818:Animals; D001369:Axons / Q000502:physiology; D002465:Cell Movement; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D051379:Mice; D009420:Nervous System / Q000196:embryology*; D009474:Neurons / Q000502:physiology; D020794:Receptor Protein-Tyrosine Kinases / Q000502:physiology*
D020794:Receptor Protein-Tyrosine Kinases