title: Anterior ischemic optic neuropathy and activated protein C resistance. A case report and review of the literature.
abstract: Nonarteritic anterior ischemic optic neuropathy (AION) is a well-described entity that is believed to be caused by abnormal anatomy of the optic disc and to be precipitated by several stressors or disease states. Activated protein C resistance (APCR) is a recently described mutation of factor V (FV) gene that renders FV resistant to cleavage by activated protein C. APCR predisposes to thrombotic events. The case of a 61-year-old woman with AION and activated protein C resistance is presented, and the management is discussed. We thoroughly review the literature on these two conditions. We propose that a prospective analysis of the potential role of APCR in some cases of AION is needed and suggest that physicians consider this and other prothrombotic states when evaluating patients with AION.
authors.affiliation: Department of Neurology, Columbia Presbyterian Medical Center, New York, New York 10032-2603, USA.
authors.forename: B B
authors.initials: BB
authors.lastname: Worrall
authors.forename: G
authors.initials: G
authors.lastname: Moazami
authors.forename: J G
authors.initials: JG
authors.lastname: Odel
authors.forename: M M
authors.initials: MM
authors.lastname: Behrens
mesh_terms: D005165:Factor V / Q000235:genetics; D005260:Female; D006801:Humans; D008875:Middle Aged; D009898:Optic Disk / Q000098:blood supply*; D018917:Optic Neuropathy, Ischemic / Q000150:complications* / Q000378:metabolism / Q000503:physiopathology; D010314:Partial Thromboplastin Time; D011486:Protein C / Q000378:metabolism*; D013927:Thrombosis / Q000150:complications / Q000378:metabolism / Q000503:physiopathology
chemical_list: D011486:Protein C; D005165:Factor V