Multiple drug-resistant Shigella dysenteriae type 1 in Rajbari district, Bangladesh.
Twenty-one Shigellae isolates were obtained from bloody faecal specimens of diarrhoeal patients at Rajbari District Hospital from January 1994 to June 1995, and serogrouped. Fourteen (67%) isolates belonged to the Shigella dysenteriae serogroup and 7 (33%) to Shigella flexneri serogroup. Shigella dysenteriae strains were further serotyped; all were Shigella dysenteriae 1. Each strain was tested for resistance to 6 common antimicrobial agents. The two strains had different antibiotic susceptibility patterns. The 7 S. flexneri showed 6 different resistant patterns and the 14 S. dysenteriae 1 isolates had 4 resistance patterns. One of the S. dysenteriae 1 isolates was resistant to all 6 antimicrobial agents; 10 to 5, and twice to a different combination of 4 antimicrobials. The 14 (100%) S. dysenteriae 1 strains were resistant to 3 major antimicrobial agents: ampicillin, tetracycline, and chloramphenicol; 13 (93%) were resistant to 5 agents: ampicillin, tetracycline, chloramphenicol, trimethoprim-sulphamethoxazole, and nalidixic acid. Ciprofloxacin was the only drug active against all 7 S. flexneri and 13 of the 14 (93%) S. dysenteriae 1 strains.
Jahan
Y
Y
Microbiology Department, Institute of Epidemiology, Disease Control and Research, Rajbari; Bangladesh.
Hossain
A
A
D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001459:Bangladesh; D002648:Child; D002675:Child, Preschool; D003967:Diarrhea / Q000188:drug therapy / Q000382:microbiology; D018432:Drug Resistance, Multiple; D004405:Dysentery, Bacillary / Q000188:drug therapy* / Q000382:microbiology*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008826:Microbial Sensitivity Tests; D012762:Shigella dysenteriae / Q000187:drug effects*; D012763:Shigella flexneri / Q000187:drug effects
D000900:Anti-Bacterial Agents