title: [X-chromosome inactivation in mammalian ontogeny].
abstract: This review is dedicated to a very interesting problem of developmental genetics: dose compensation of the X-chromosome genes in somatic cells of female mammals. A sequence of events related to X-chromosome inactivation during cell differentiation at the early embryonic stages, association of distributed X-chromosome heterochromatization with developmental pathologies, evolutionary origin of X-inactivation, and its relationship with genomic imprinting are considered.
authors.forename: V N
authors.initials: VN
authors.lastname: Evdokimova
authors.forename: S A
authors.initials: SA
authors.lastname: Nazarenko
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000235:genetics; D004303:Dosage Compensation, Genetic; D005314:Embryonic and Fetal Development / Q000235:genetics; D005260:Female; D018392:Genomic Imprinting / Q000235:genetics; D006570:Heterochromatin / Q000235:genetics; D006801:Humans; D008297:Male; D008322:Mammals / Q000196:embryology / Q000235:genetics*
chemical_list: D006570:Heterochromatin