title: Cumulative risk of bypass, amputation or death following percutaneous transluminal angioplasty.
abstract: OBJECTIVE
  To define cumulative risk of reconstruction, amputation or death following percutaneous transluminal angioplasty (PTA).
  
  
  METHODS
  Non-randomised observational study.
  
  
  METHODS
  Two hundred and thirty-four PTAs in 212 patients. Minimum follow-up 6 months. Examination of data collected prospectively on manual card index. Examination of radiology and theatre ledgers over 2.5-year period. District Information System (Dis Data). Life-table analysis.
  
  
  RESULTS
  The cumulative risks of reconstruction at 12 months were 14.9% and 6.7%, respectively, following angioplasties below and above the inguinal ligament. Major and minor amputations were more common if the original lesions were below the inguinal ligament (relative risk (RR) 3.32, confidence interval (CI) CI 0.42-26.26 and RR 4.24, CI 0.055-32.9, respectively). They were also more likely in diabetic compared with non-diabetic patients (RR 9.95, CI 2.85-34.47 and RR 3.66, CI 1.28-10.44, respectively). No patient who presented with claudication underwent amputation. Death was more common in patients originally presenting with rest pain or gangrene than claudication (RR 3.94, CI 1.51-10.31).
  
  
  CONCLUSIONS
  This study confirms the poor outlook of diabetic patients with peripheral vascular disease or those presenting with rest pain, ulceration or gangrene. Percutaneous transluminal angioplasty was associated with approximately 80% limb salvage rate in those patients during the duration of the study.
authors.affiliation: Hillingdon Health Authority, Reading, U.K.
authors.forename: W
authors.initials: W
authors.lastname: Gutteridge
authors.forename: E P
authors.initials: EP
authors.lastname: Torrie
authors.forename: R B
authors.initials: RB
authors.lastname: Galland
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000671:Amputation, Surgical / Q000401:mortality / Q000706:statistics & numerical data*; D000800:Angioplasty, Balloon / Q000401:mortality / Q000706:statistics & numerical data*; D001157:Arterial Occlusive Diseases / Q000401:mortality / Q000628:therapy; D001166:Arteriovenous Shunt, Surgical / Q000401:mortality / Q000706:statistics & numerical data*; D004739:England / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007511:Ischemia / Q000401:mortality / Q000628:therapy; D007866:Leg / Q000098:blood supply; D015993:Life Tables; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012307:Risk Factors; D013997:Time Factors; D017211:Treatment Failure