[The effect of phenol antioxidants on the development of alloxan diabetes in rats].
Experiments were conducted on an alloxan diabetes model to study the preventive effects of the phenol antioxidants ionol and probucol. Ionol showed a tendency towards inhibition of glycemia and free radical oxidation of lipids. Probucol effectively inhibited the development of glycemia, hyperlipidemia, and intensification of autooxidation in the vascular wall. On the grounds of the results it is concluded that inclusion of probucol into complex treatment of patients suffering from diabetes mellitus with vascular complications is expedient.
Bobyreva
L E
LE
D000496:Alloxan; D000818:Animals; D000924:Anticholesteremic Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D000975:Antioxidants / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D002084:Butylated Hydroxytoluene / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology / Q000517:prevention & control*; D005609:Free Radicals; D006943:Hyperglycemia / Q000188:drug therapy; D006949:Hyperlipidemias / Q000188:drug therapy; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D011341:Probucol / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D014655:Vascular Resistance / Q000187:drug effects
D000924:Anticholesteremic Agents; D000975:Antioxidants; D005609:Free Radicals; D002084:Butylated Hydroxytoluene; D000496:Alloxan; D011341:Probucol