Effect of aging on vulnerability of striatal D1 and D2 dopamine receptor-containing neurons to kainic acid.
Kainic acid lesions elicit reductions in ligand binding to both D1 and D2 striata dopamine receptors in young and old rats. Relative reductions are greatest for both receptors in young animals than old. In addition, D1 receptor binding is reduced more than D2 at both ages. These findings support the idea that those dopamine receptor neurons lost during aging may reside in a kainic acid sensitive population.
Zhang
L
L
Laboratory of Cellular and Molecular Biology, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Johns Hopkins Bayview Medical Center, Baltimore, MD 21224, USA.
Joseph
J A
JA
Roth
G S
GS
D000375:Aging / Q000502:physiology*; D000818:Animals; D003342:Corpus Striatum / Q000737:chemistry / Q000166:cytology; D018690:Excitatory Amino Acid Agonists / Q000494:pharmacology*; D007608:Kainic Acid / Q000494:pharmacology*; D009474:Neurons / Q000737:chemistry / Q000187:drug effects*; D009498:Neurotoxins / Q000494:pharmacology; D011485:Protein Binding / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D017447:Receptors, Dopamine D1 / Q000032:analysis / Q000378:metabolism*; D017448:Receptors, Dopamine D2 / Q000032:analysis / Q000378:metabolism*
D018690:Excitatory Amino Acid Agonists; D009498:Neurotoxins; D017447:Receptors, Dopamine D1; D017448:Receptors, Dopamine D2; D007608:Kainic Acid