[Activation of transcription in eukaryotic cells: interactions between transcription factors and components of the basal transcriptional mechanism].
Regulation of transcription in eucaryotes is achieved by two classes of transcription factors, GTFs (general transcription factors), which are components of the basal machinery, and sequence- and tissue-specific transcription factors. In this review, recent insights into the structure and function of components from the basal transcriptional machinery are discussed. The mechanisms of transcriptional activation involving direct interactions between trans-activators and the basal machinery are also presented.
Diagana
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Département de Biologie Moléculaire, Institut Pasteur, Paris, France.
D004268:DNA-Binding Proteins / Q000235:genetics; D004347:Drug Interactions; D005057:Eukaryotic Cells; D005786:Gene Expression Regulation / Q000235:genetics; D066298:In Vitro Techniques; D012319:RNA Polymerase II / Q000235:genetics; D016385:TATA Box; D015534:Trans-Activators / Q000235:genetics / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics* / Q000378:metabolism; D019473:Transcription Factors, TFII / Q000235:genetics; D014158:Transcription, Genetic / Q000235:genetics*; D015533:Transcriptional Activation
D004268:DNA-Binding Proteins; D015534:Trans-Activators; D014157:Transcription Factors; D019473:Transcription Factors, TFII; D012319:RNA Polymerase II