title: Circulating lipids and cardiovascular risk in newly diagnosed non-insulin-dependent diabetic subjects in India.
abstract: Circulating concentrations of total cholesterol, triglycerides, non-esterified fatty acids (NEFA), glycerol, and 3-hydroxybutyrate (3-HB) were measured in 133 subjects with normal glucose tolerance (NGT), 78 with impaired-glucose-tolerance (IGT) and 189 non-insulin dependent (Type 2) diabetic (NIDDM) patients. Plasma cholesterol concentration was similar in the three groups; NGT (4.2 (2.3-7.5) mmol l-1, median (range)), IGT (4.7 (2.7-6.3)) and NIDDM (4.3 (2.3-6.9)). Plasma triglycerides (NGT 0.88 (0.37-2.80), IGT 1.26 (0.43-3.82) and NIDDM 1.38 (0.62-3.91) mmol l-1) and NEFA (NGT 0.81 (0.29-1.58), IGT 1.02 (0.33-1.87) and NIDDM 1.02 (0.48-2.77) mmol l-1) were higher in the two hyperglycaemic groups, but blood 3-HB concentration was similar in the three groups. Plasma cholesterol concentration in these subjects is lower than that reported in white Caucasians in the UK and USA and migrant Indian NIDDM patients in the UK. In NIDDM patients plasma cholesterol concentration was related to age, body mass index (BMI), and plasma glucose concentration while plasma triglyceride concentration was related to plasma NEFA and insulin (IRI) concentration. Evidence of ischaemia on electrocardiography in patients with diabetes was associated with higher age, blood pressure, plasma triglyceride, glucose, and IRI concentrations.
authors.affiliation: Diabetes Unit, King Edward Memorial Hospital and Research Centre, Pune, India.
authors.forename: K M
authors.initials: KM
authors.lastname: Shelgikar
authors.forename: S S
authors.initials: SS
authors.lastname: Naik
authors.forename: M
authors.initials: M
authors.lastname: Khopkar
authors.forename: D S
authors.initials: DS
authors.lastname: Bhat
authors.forename: K N
authors.initials: KN
authors.lastname: Raut
authors.forename: C V
authors.initials: CV
authors.lastname: Joglekar
authors.forename: M E
authors.initials: ME
authors.lastname: Gerard
authors.forename: C S
authors.initials: CS
authors.lastname: Yajnik
mesh_terms: D020155:3-Hydroxybutyric Acid; D000328:Adult; D000419:Albuminuria / Q000150:complications / Q000652:urine; D000787:Angina Pectoris / Q000150:complications; D002318:Cardiovascular Diseases / Q000097:blood / Q000453:epidemiology*; D002784:Cholesterol / Q000097:blood; D015331:Cohort Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications; D004562:Electrocardiography; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D018149:Glucose Intolerance / Q000097:blood* / Q000150:complications; D005951:Glucose Tolerance Test; D005990:Glycerol / Q000097:blood; D006801:Humans; D006885:Hydroxybutyrates / Q000097:blood; D007194:India / Q000453:epidemiology; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood
chemical_list: D005230:Fatty Acids, Nonesterified; D006885:Hydroxybutyrates; D008055:Lipids; D014280:Triglycerides; D002784:Cholesterol; D005990:Glycerol; D020155:3-Hydroxybutyric Acid