title: [Mechanisms of pyrimidine derivatives systemic immunomodulating effect].
abstract: Experiments on guinea pigs showed that xymedon in a dose of 30 mg/kg stimulates nucleic acid synthesis in thymocytes and increases the blood serum nucleic acid content. Xymedon increased secretion of endogenous DNA by human lymphocytes stimulated with PNA in vitro. The systemic immunotropic mechanisms of pyrimidine derivatives are discussed.
authors.forename: Iu D
authors.initials: IuD
authors.lastname: Slabnov
authors.forename: G V
authors.initials: GV
authors.lastname: Cherepnev
authors.forename: A P
authors.initials: AP
authors.lastname: Tsibulkin
authors.forename: R S
authors.initials: RS
authors.lastname: Garaev
mesh_terms: D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D000918:Antibody Specificity / Q000187:drug effects; D004247:DNA / Q000378:metabolism; D006168:Guinea Pigs; D006801:Humans; D000960:Hypolipidemic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D011743:Pyrimidines / Q000008:administration & dosage / Q000494:pharmacology*; D012313:RNA / Q000378:metabolism; D013050:Spectrometry, Fluorescence; D013601:T-Lymphocytes / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D013950:Thymus Gland / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism
chemical_list: D000960:Hypolipidemic Agents; D011743:Pyrimidines; C069705:xymedon; D012313:RNA; D004247:DNA