title: Disappearance of the Epstein-Barr virus in a relapse of Hodgkin's disease.
abstract: Hodgkin's disease (HD) is associated with the Epstein-Barr virus (EBV) in approximately half of cases. This is a report of a case of nodular sclerosing HD of the B-cell type that was associated with EBV in the initial manifestation, but was found to be EBV-negative in the relapse of the tumour. Both tumours displayed similar clinical, pathological, and immunohistochemical features. This finding implies that in a given individual EBV can be lost from malignant tumours and therefore shows that the EBV infection is not required to maintain neoplastic growth of HD tumour cells.
authors.affiliation: Consultation and Reference Center for Lymph Node Pathology and Hematopathology, Institute of Pathology, Klinikum Benjamin Franklin, Free University of Berlin, Germany.
authors.forename: H J
authors.initials: HJ
authors.lastname: Delecluse
authors.forename: T
authors.initials: T
authors.lastname: Marafioti
authors.forename: M
authors.initials: M
authors.lastname: Hummel
authors.forename: F
authors.initials: F
authors.lastname: Dallenbach
authors.forename: I
authors.initials: I
authors.lastname: Anagnostopoulos
authors.forename: H
authors.initials: H
authors.lastname: Stein
mesh_terms: D000956:Antigens, Viral / Q000032:analysis; D002675:Child, Preschool; D004279:DNA, Viral / Q000032:analysis; D004591:Electrophoresis, Polyacrylamide Gel; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000276:immunology; D006689:Hodgkin Disease / Q000473:pathology / Q000821:virology*; D006801:Humans; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D008297:Male; D009364:Neoplasm Recurrence, Local; D016133:Polymerase Chain Reaction
chemical_list: D000956:Antigens, Viral; D004279:DNA, Viral