Antibodies to the hepatitis B e antigen (HBeAg) can be induced in HBeAg-transgenic mice by adoptive transfer of a specific T-helper 2 cell clone.
Production of antibody to hepatitis B e antigen (HBeAg); i.e., anti-HBe antibody,) in HBeAg-transgenic mice is believed to be mediated by T-helper 2 (Th2) cells. Injection of an HBeAg-specific Th2 clone into HBeAg-transgenic H-2k mice induced anti-HBe antibody production, confirming the function of Th2 cells in this model system.
Hultgren
C
C
Division of Clinical Virology, Huddinge University Hospital, Sweden.
Milich
D R
DR
Sällberg
M
M
D019264:Adoptive Transfer; D000818:Animals; D002999:Clone Cells; D006508:Hepatitis Antibodies / Q000096:biosynthesis* / Q000276:immunology; D006512:Hepatitis B Core Antigens / Q000276:immunology; D006513:Hepatitis B e Antigens / Q000276:immunology*; D007124:Immunoenzyme Techniques; D051379:Mice; D008822:Mice, Transgenic; D018418:Th2 Cells / Q000276:immunology*
D006508:Hepatitis Antibodies; D006512:Hepatitis B Core Antigens; D006513:Hepatitis B e Antigens