title: Effects of ketamine and pentobarbitone on acetylcholine release from the rat frontal cortex in vivo.
abstract: We have studied the effects of ketamine and pentobarbitone on acetylcholine (ACh) release from the rat frontal cortex using microdialysis. Ketamine 25, 50 and 100 mg kg-1 increased ACh release from the frontal cortex to 286%, 253% and 381% of basal release, respectively. In contrast, pentobarbitone 10, 20 and 40 mg kg-1 caused 73%, 78% and 96% inhibition of basal levels, respectively. The results suggest that ketamine and pentobarbitone have opposite effects on ACh release from the rat frontal cortex, as seen previously in the rat hippocampus.
authors.affiliation: Department of Anesthesiology, Yokohama City University School of Medicine, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Kikuchi
authors.forename: Y
authors.initials: Y
authors.lastname: Wang
authors.forename: H
authors.initials: H
authors.lastname: Shinbori
authors.forename: K
authors.initials: K
authors.lastname: Sato
authors.forename: F
authors.initials: F
authors.lastname: Okumura
mesh_terms: D000109:Acetylcholine / Q000378:metabolism*; D000778:Anesthetics, Dissociative / Q000494:pharmacology*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005625:Frontal Lobe / Q000187:drug effects* / Q000378:metabolism; D006993:Hypnotics and Sedatives / Q000494:pharmacology*; D007649:Ketamine / Q000494:pharmacology*; D008297:Male; D017551:Microdialysis; D010424:Pentobarbital / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000778:Anesthetics, Dissociative; D006993:Hypnotics and Sedatives; D007649:Ketamine; D010424:Pentobarbital; D000109:Acetylcholine