Left-right asymmetry in vertebrates.
All vertebrates develop with a distinct, invariant, left-right (L-R) body asymmetry. Recently, a number of molecules have been shown to be expressed asymmetrically with respect to the L-R axis during early embryogenesis. The temporal expression patterns of these molecules, in combination with embryo manipulation and genetic experiments, indicate that they may represent elements of a conserved pathway governing embryonic handedness.
Varlet
I
I
Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA.
Robertson
E J
EJ
D000818:Animals; D019521:Body Patterning / Q000235:genetics; D018507:Gene Expression Regulation, Developmental; D006321:Heart / Q000196:embryology; D015398:Signal Transduction / Q000235:genetics; D014714:Vertebrates / Q000196:embryology* / Q000235:genetics