MHC class I antigen processing pathways.
The multistep process that culminates in major histocompatibility complex (MHC) class I presentation of foreign of self-peptides begins in the last phases of protein catabolism. Although the individual roles of many key molecules-such as proteasomes, the transporter associated with antigen processing, and various endoplasmic reticulum chaperones-have recently been elucidated, there still remain many questions regarding processing of proteins into MHC class I bound peptides. This review summarizes the recent developments in antigen processing for MHC class I molecules, with a focus on how proteins are believed to be sampled and selected for degradation.
Maffei
A
A
International Institute of Genetics and Biophysics, CNR, Naples, Italy.
Papadopoulos
K
K
Harris
P E
PE
D017951:Antigen Presentation; D006680:HLA Antigens / Q000737:chemistry / Q000378:metabolism; D015395:Histocompatibility Antigens Class I / Q000276:immunology* / Q000378:metabolism*; D006801:Humans; D008285:Major Histocompatibility Complex / Q000276:immunology; D010455:Peptides / Q000276:immunology / Q000378:metabolism
D006680:HLA Antigens; D015395:Histocompatibility Antigens Class I; D010455:Peptides