title: Cholinergic and peptidergic regulation of siphon/mantle function in the zebra mussel, Dreissena polymorpha.
abstract: Neurotransmitter regulation of the siphon and adjacent mantle region of bivalves has not previously been examined. In the biofouling bivalve, Dreissena polymorpha, acetylcholine and FMRFamide both elicited contractions of siphon/mantle preparations. Hexamethonium bromide inhibited acetylcholine-elicited contractions but had no effect on FMRFamide-elicited contractions. FMRFamide-like immunoreactivity and chromatographic evidence for acetylcholine were found in central ganglia and the siphon/mantle region. Extracts of siphons, gonads, and gills, separated on Sephadex G-25, also contained macromolecules larger than acetylcholine and FMRFamide that caused siphon/mantle contraction. These results demonstrate regulation of contraction by several potential neurotransmitter agents in a new bivalve preparation, the siphon/mantle.
authors.affiliation: Department of Physiology, Wayne State University, Detroit, MI 48201, USA. jeffram@med.wayne.edu
authors.forename: J L
authors.initials: JL
authors.lastname: Ram
authors.forename: F
authors.initials: F
authors.lastname: Baidoun
authors.forename: M L
authors.initials: ML
authors.lastname: Ram
authors.forename: R P
authors.initials: RP
authors.lastname: Croll
mesh_terms: D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D049872:Bivalvia / Q000187:drug effects / Q000502:physiology*; D018678:Cholinergic Agents / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D019835:FMRFamide; D005730:Ganglionic Blockers / Q000494:pharmacology*; D018738:Hexamethonium / Q000494:pharmacology; D007447:Invertebrate Hormones / Q000494:pharmacology; D009119:Muscle Contraction; D009132:Muscles / Q000187:drug effects / Q000502:physiology; D009479:Neuropeptides / Q000494:pharmacology; D018377:Neurotransmitter Agents / Q000494:pharmacology*; D014020:Tissue Extracts / Q000494:pharmacology
chemical_list: D018678:Cholinergic Agents; D005730:Ganglionic Blockers; D007447:Invertebrate Hormones; D009479:Neuropeptides; D018377:Neurotransmitter Agents; D014020:Tissue Extracts; D018738:Hexamethonium; D019835:FMRFamide; D000109:Acetylcholine