[Bone marrow changes in HIV-positive patients (clinical, cytological, histological, and ultrastructural study of 57 cases)].
The authors take into consideration clinical, cytological, histological and ultrastructural pattern of 57 HIV+ patients. They want to quantify bone marrow alterations and research their relation with haematological pattern of these patients. They think that peripheral haematological deficit is related with cellular and stromal alterations of the bone marrow. In fact there are many morphological cellular alterations. The most characteristic are that of megakaryocytes. The alterations of these cells are, probably, responsible for bone marrow early sclerosis of these patients. The plasma cells are also numerous and activated. They respect an immunological response.
Oddi
G
G
Servizio di Anatomia Citologica ed Istologia Patologica, Ospedale C. Forlanin, Roma.
Rebeck
L
L
Storniello
G
G
De Blasio
A
A
Papetti
C
C
De Laurenzi
A
A
Modesti
A
A
Modica
A
A
D000328:Adult; D001853:Bone Marrow / Q000473:pathology*; D001856:Bone Marrow Examination; D002452:Cell Count; D005260:Female; D015658:HIV Infections / Q000473:pathology*; D006801:Humans; D016483:Lymphoma, AIDS-Related / Q000473:pathology; D008297:Male; D008533:Megakaryocytes / Q000473:pathology; D009336:Necrosis; D015388:Organelles / Q000648:ultrastructure; D010950:Plasma Cells / Q000473:pathology; D055728:Primary Myelofibrosis / Q000473:pathology