title: Focal infections due to non-typhi Salmonella in patients with AIDS: report of 10 cases and review.
abstract: Bacteremia due to non-typhi Salmonella is frequent in human immunodeficiency virus (HIV)-infected patients; however, focal complications rarely have been reported. Ten of 38 HIV-infected patients (26.3%) with salmonellosis documented over a period of 9 years had focal suppurative complications; only 19 (3.9%) of 490 adults without HIV infection who were seen during the same period had focal complications (P = .001). Infections of the urinary tract, lungs, and soft tissue, followed by arthritis, endocarditis, and meningitis were most frequently seen. Although salmonellosis occasionally heralded HIV infection, most patients were severely immunocompromised and had CD4 cell counts of <100/mm3. The mortality rate was 50%, equivalent to that observed among patients with other immunosuppressive disorders (52.6%). Major emphasis must be put on intensive therapy for salmonella bacteremia and prevention of its complications.
authors.affiliation: Division of Infectious Diseases, Fundación Jiménez Diaz, Universidad Autónoma de Madrid, Spain.
authors.forename: M L
authors.initials: ML
authors.lastname: Fernández Guerrero
authors.forename: J M
authors.initials: JM
authors.lastname: Ramos
authors.forename: A
authors.initials: A
authors.lastname: Núñez
authors.forename: M
authors.initials: M
authors.lastname: Cuenca
authors.forename: M
authors.initials: M
authors.lastname: de Górgolas
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000150:complications* / Q000188:drug therapy / Q000276:immunology; D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001170:Arthritis, Infectious / Q000150:complications; D018791:CD4 Lymphocyte Count; D004697:Endocarditis, Bacterial / Q000150:complications; D005260:Female; D006801:Humans; D016867:Immunocompromised Host; D008297:Male; D016920:Meningitis, Bacterial / Q000150:complications; D008875:Middle Aged; D018410:Pneumonia, Bacterial / Q000150:complications; D012480:Salmonella Infections / Q000150:complications* / Q000188:drug therapy / Q000276:immunology; D018461:Soft Tissue Infections / Q000150:complications; D013492:Suppuration / Q000150:complications; D014552:Urinary Tract Infections / Q000150:complications
chemical_list: D000900:Anti-Bacterial Agents