Immunocytochemical studies of neurotrophins in cerebral motor cortex in Amyotrophic Lateral Sclerosis.
Neurotrophin-like immunoreactivity was studied in post-mortem motor cerebral cortex from patients with Amyotrophic Lateral Sclerosis (ALS) and controls. Neurotrophin-4/5 immunoreactivity was seen in small-(12-25 microm), medium-(26-39 microm), and large-(> 40 microm), neurones, neurotrophin-3 was seen in medium and small neurones, while brain-derived neurotrophic factor was restricted to small neurones. No difference in number or intensity of immunostained neurones was found between ALS and controls.
Duberley
R M
RM
Department of Anatomy and Developmental Biology, Royal Free Hospital School of Medicine, London, UK.
Johnson
I P
IP
Anand
P
P
Leigh
P N
PN
Cairns
N J
NJ
D000368:Aged; D000369:Aged, 80 and over; D000690:Amyotrophic Lateral Sclerosis / Q000378:metabolism*; D019208:Brain-Derived Neurotrophic Factor / Q000032:analysis; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D009044:Motor Cortex / Q000737:chemistry*; D009414:Nerve Growth Factors / Q000032:analysis*; D018696:Neuroprotective Agents / Q000032:analysis; D020933:Neurotrophin 3
D019208:Brain-Derived Neurotrophic Factor; D009414:Nerve Growth Factors; D018696:Neuroprotective Agents; D020933:Neurotrophin 3; C071951:neurotrophin 5; C073922:neurotrophin 4