title: In vitro susceptibilities to amphotericin B, itraconazole, and miconazole of filamentous fungi isolated from patients with cystic fibrosis.
abstract: The antimicrobial activities of amphotericin B, itraconazole, and miconazole against 101 filamentous fungi from patients with cystic fibrosis were tested by a reproducible microdilution method. Itraconazole was very active against Aspergillus species and Scedosporium species (MIC at which 90% of the isolates were inhibited [MIC90], 0.06 to 0.5 mg/liter), whereas amphotericin B was less effective (MIC90, 0.5 to 8 mg/liter).
authors.affiliation: Laboratoire de Parasitologie, Service de Microbiologie, Hôpital Necker-Enfants Malades, Paris, France.
authors.forename: C
authors.initials: C
authors.lastname: Hennequin
authors.forename: N
authors.initials: N
authors.lastname: Benailly
authors.forename: C
authors.initials: C
authors.lastname: Silly
authors.forename: M
authors.initials: M
authors.lastname: Sorin
authors.forename: P
authors.initials: P
authors.lastname: Scheinmann
authors.forename: G
authors.initials: G
authors.lastname: Lenoir
authors.forename: J L
authors.initials: JL
authors.lastname: Gaillard
authors.forename: P
authors.initials: P
authors.lastname: Berche
mesh_terms: D000666:Amphotericin B / Q000494:pharmacology; D000935:Antifungal Agents / Q000494:pharmacology*; D001230:Aspergillus / Q000187:drug effects*; D003550:Cystic Fibrosis / Q000382:microbiology*; D017964:Itraconazole / Q000494:pharmacology; D008825:Miconazole / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D003904:Mitosporic Fungi / Q000187:drug effects*
chemical_list: D000935:Antifungal Agents; D017964:Itraconazole; D008825:Miconazole; D000666:Amphotericin B