title: Omeprazole, a specific gastric secretion inhibitor on oxynticopeptic cells, reduces gizzard erosion in broiler chicks fed with toxic fish meals.
abstract: The relation between gizzard erosion-black vomit (GE-BV) and gastric secretion is not completely understood. A pharmacological approach to reduce the presence of GE-BV in chicks due to fish meal in diets is also unknown. In this study the use of omeprazole, a H+/K+ ATPase inhibitor, and fish meals of different biotoxicological characteristics, showed that: 1) Omeprazole decreased total gastric acid content, GE scores and severe GE (SGE) cases, in a dose-dependent manner. This reduction was significant at levels higher than 20 mg omeprazole/Kg body weight (BW)/day (p < 0.01). The addition of 50 mg omeprazole/kg BW/day almost completely prevented the incidence of SGE cases and reduced in 50% GE score in chicks (p < 0.01). 2) A significant reduction in specific mortality, near 90%, was also seen with all toxic fish meals when omeprazole (50 mg/Kg BW/day) was added to experimental diets in comparison to control groups. However, no mortality was observed when omeprazole was added to diets containing non-toxic fish meals. 3) In chicks fed with toxic fish meals, addition of different amounts of omeprazole to diets changed the relative weight of proventriculus (p < 0.01) and gizzard (p < 0.05). Maximum effect was obtained with omeprazole concentration higher than 50 mg/Kg BW/day. 4) Omeprazole did not change feed intake in chicks fed with toxic fish meal. However, in some fish meal a reduction on weight gain was observed with the addition of omeprazole.
authors.affiliation: Departamento de Investigación Desarrollo, INUAL Ltda (Nutrición y Biotecnología), Santiago, Chile.
authors.forename: J P
authors.initials: JP
authors.lastname: Hinrichsen
authors.forename: M
authors.initials: M
authors.lastname: Neira
authors.forename: C
authors.initials: C
authors.lastname: Lopez
authors.forename: M
authors.initials: M
authors.lastname: Chiong
authors.forename: M P
authors.initials: MP
authors.lastname: Ocaranza
authors.forename: R
authors.initials: R
authors.lastname: Gallardo
authors.forename: M
authors.initials: M
authors.lastname: Rutman
authors.forename: J
authors.initials: J
authors.lastname: Blamey
authors.forename: S
authors.initials: S
authors.lastname: Lavandero
mesh_terms: D000284:Administration, Oral; D000821:Animal Feed / Q000009:adverse effects*; D000818:Animals; D000897:Anti-Ulcer Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002645:Chickens; D004305:Dose-Response Relationship, Drug; D004791:Enzyme Inhibitors / Q000627:therapeutic use; D005396:Fish Products / Q000009:adverse effects; D005399:Fishes; D005745:Gastric Acidity Determination; D005895:Gizzard, Avian / Q000187:drug effects* / Q000473:pathology; D008297:Male; D009026:Mortality; D009853:Omeprazole / Q000008:administration & dosage / Q000627:therapeutic use*; D009929:Organ Size / Q000187:drug effects; D011201:Poultry Diseases / Q000188:drug therapy* / Q000209:etiology; D054328:Proton Pump Inhibitors; D014839:Vomiting / Q000662:veterinary*; D015430:Weight Gain / Q000187:drug effects
chemical_list: D000897:Anti-Ulcer Agents; D004791:Enzyme Inhibitors; D054328:Proton Pump Inhibitors; D009853:Omeprazole