[Experimental study on different concentration alcohol humidifying oxygen supply improving hypoxia caused by pulmonary edema].
In order to research the best alcoholic concentration in the humidifying bottle when pneumonedema oxygen inhalation, 32 rabbits, divided into 4 groups, are replicated into pneumonedema models using method of rapid transfusion, and given oxygen inhalation with 20%, 50%, 70%, and 90% alcohol as humidifying agent (shortly called alcoholic oxygen). The results are as follows: using 20% alcohol as humidifying agent, the increasing amplitude of blood PaO2 is 147.30% (P < 0.001), the injury to the pulmonary bronchial mucosa and the wall of pulmonary alveoli is slight; using 50% alcohol, the increasing amplitude of blood PaO2 is 39.46% (P < 0.001), the injury to the parts mentioned above exacerbates and bronchiole cavity mucosa has moderate bleeding; using 70% alcohol, the increasing amplitude of blood PaO2 is 21.97% (P < 0.05), pneumorrhagia occurs; using 90% alcohol, the increasing amplitude of blood PaO2 is 94.46% (P < 0.01), a great number of blood cells aggregate inside the pulmonary alveoli and the bronchiole. This study proves that choosing 20% alcohol as humidifying agent has the best result, and as well, the explanation of the mechanism of alcohol suppressing foam, meaning being able to decrease only the surface tension of the foam inside the pulmonary alveoli, is incomprehensive, and the nature of the material itself forming foam has decisive function.
Jiang
X W
XW
Nursing Teaching and Researching Office, Jinan Higher Medical Academy PLA, Jinan.
Gao
M Z
MZ
Liang
J H
JH
D000280:Administration, Inhalation; D000438:Alcohols / Q000627:therapeutic use*; D000818:Animals; D001784:Blood Gas Analysis; D004353:Drug Evaluation, Preclinical; D006801:Humans; D000860:Hypoxia / Q000209:etiology / Q000628:therapy*; D009330:Nebulizers and Vaporizers; D010102:Oxygen Inhalation Therapy; D011654:Pulmonary Edema / Q000150:complications*; D011817:Rabbits
D000438:Alcohols