title: MDMA induced hyperthermia: a survivor with an initial body temperature of 42.9 degrees C.
abstract: A young male survived hyperpyrexia (42.9 degrees C) following MDMA ("Ecstasy") ingestion. He developed convulsions, rhabdomyolysis, metabolic acidosis, and respiratory failure. This was successfully managed by assisted ventilation, aggressive fluid therapy, and the early administration of dantrolene, in addition to cooling measures. This is the first report of a survivor with such a severe hyperpyrexia.
authors.affiliation: Academic Unit of Anaesthesia, Leeds General Infirmary.
authors.forename: A
authors.initials: A
authors.lastname: Mallick
authors.forename: A R
authors.initials: AR
authors.lastname: Bodenham
mesh_terms: D000328:Adult; D001784:Blood Gas Analysis; D001831:Body Temperature; D003620:Dantrolene / Q000627:therapeutic use; D004636:Emergency Service, Hospital; D005334:Fever / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy; D006213:Hallucinogens; D006801:Humans; D008297:Male; D009125:Muscle Relaxants, Central / Q000627:therapeutic use; D018817:N-Methyl-3,4-methylenedioxyamphetamine; D019966:Substance-Related Disorders / Q000150:complications*
chemical_list: D006213:Hallucinogens; D009125:Muscle Relaxants, Central; D003620:Dantrolene; D018817:N-Methyl-3,4-methylenedioxyamphetamine