Activity and distribution of superoxide dismutase in the layers of polyester grafts.
The aim of the present study was to evaluate superoxide dismutase (Cu, Zn-SOD) activity in the principal layers of polyester grafts implanted into the abdominal aorta of dogs. The grafts were examined 7 days and 1, 4 and 12 months after the operation. It was found that SOD activity occurred in all polyester graft layers during the whole experiment. The neointima activity ws 1.5-fold lower during the 1st month; with the passage of time, it became 2-fold lower than in the normal aorta (p < 0.01). SOD activity in the medial and outer graft layers behaved similarly: it was lowest after 7 days, increased after 1 month and significantly decreased after 4 and 12 months (p < 0.01). Our study shows that the activity of SOD is low in polyester grafts and it can thus be inferred that protection against the superoxide anion is inadequate.
Glowinski
J
J
Department of Vascular Surgery and Transplantology, University School of Medicine, Białystok, Poland.
Farbiszewski
R
R
Glowinski
S
S
Chwiecko
M
M
D000818:Animals; D001012:Aorta, Abdominal / Q000601:surgery; D001807:Blood Vessel Prosthesis; D004285:Dogs; D008297:Male; D011091:Polyesters; D013482:Superoxide Dismutase / Q000032:analysis*; D013997:Time Factors; D017539:Tunica Intima / Q000737:chemistry; D017540:Tunica Media / Q000737:chemistry
D011091:Polyesters; D013482:Superoxide Dismutase