title: Early changes in fluorine-18-FDG uptake during radiotherapy.
abstract: The aim of this case study was to quantify metabolic changes in tumor tissue during and directly after external radiotherapy.
  
  
  METHODS
  We performed six FDG-PET scans of the neck in a patient with two lymph node metastases of a papillary thyroid carcinoma and an antigranulocyte antibody scintigraphy of the same region to assess the inflammatory reaction.
  
  
  RESULTS
  The FDG-PET scans show an initial increase of tracer uptake in both metastases after application of 6 Gy followed by a slow but constant decline with increasing radiation dose. In the deep metastasis the FDG uptake returned to the initial level after 30 Gy total dose whereas the metabolic activity in the superficial lymph node remained high, even after 60 Gy total dose. The antigranulocyte scan demonstrated an intense inflammation in the latter metastasis.
  
  
  CONCLUSIONS
  There is an initial enhancement in metabolism induced by irradiation which is measureable by FDG-PET. With increasing dose, the metabolic activity declines constantly. The additional inflammatory reaction might contribute to the glucose uptake in irradiated tumors.
authors.affiliation: Institute for Medicine, Research Center Jülich, Germany.
authors.forename: H
authors.initials: H
authors.lastname: Hautzel
authors.forename: H W
authors.initials: HW
authors.lastname: Müller-Gärtner
mesh_terms: D000368:Aged; D002291:Carcinoma, Papillary / Q000000981:diagnostic imaging* / Q000532:radiotherapy* / Q000556:secondary; D003847:Deoxyglucose / Q000031:analogs & derivatives*; D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D006801:Humans; D007249:Inflammation; D008198:Lymph Nodes / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D009333:Neck; D019275:Radiopharmaceuticals; D013964:Thyroid Neoplasms / Q000000981:diagnostic imaging* / Q000532:radiotherapy*; D014055:Tomography, Emission-Computed
chemical_list: D005462:Fluorine Radioisotopes; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D003847:Deoxyglucose