title: Decreases in CD5+ B lymphocytes in children with the DiGeorge anomaly.
abstract: The authors evaluated the lymphocyte subsets in eight children with the DiGeorge anomaly, compared with 48 age-matched control infants. Of particular interest was the finding that the percentage and number of CD5+ B lymphocytes were decreased in seven of the eight cases. This observation may provide insight into thymic function and the interaction of the B and T cell systems in some forms of congenital and acquired immunodeficiencies.
authors.affiliation: Division of Pediatric Infectious Diseases, Epidemiology and Immunology, Emory University, Atlanta, GA 30303, USA.
authors.forename: A P
authors.initials: AP
authors.lastname: Kourtis
authors.forename: C C
authors.initials: CC
authors.lastname: Ibegbu
authors.forename: F K
authors.initials: FK
authors.lastname: Lee
authors.forename: L
authors.initials: L
authors.lastname: Vogler
authors.forename: K
authors.initials: K
authors.lastname: Philips
authors.forename: A J
authors.initials: AJ
authors.lastname: Nahmias
mesh_terms: D018941:Antigens, CD19 / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology*; D018956:CD5 Antigens / Q000276:immunology*; D002675:Child, Preschool; D004062:DiGeorge Syndrome / Q000276:immunology*; D005434:Flow Cytometry; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D018655:Lymphocyte Count; D016131:Lymphocyte Subsets
chemical_list: D018941:Antigens, CD19; D018956:CD5 Antigens