[Anticlastogenic activity of apo-carotene in vivo].
The method of chromosome aberration scoring in the bone marrow cells of C57BL/6 mice was used to study the influence of apo-carotene (AC) on the clastogenic effect of intraperitoneal injections of the following two mutagens: cyclophosphamide (CP) in a dose of 30 mg/kg and dioxidine (DN) in a dose of 300 mg/kg. AC was given per os as a food dye E160L (20% oil suspension) in doses of 0.5, 5, and 50 mg/kg (0.1, 1.0 and 10 mg/kg, respectively, on conversion to pure apo-carotene). The experiment was conducted in three variants: in simultaneous injection of the compounds for 24 h, injection of the mutagens for 24 h in 5-day treatment of the animals with AC, and in combined 5-day administration of AC and mutagens and killing of the animals 6 h after the last administration. In all variants a 10 mg/kg dose of AC reduced the clastogenic effect of CP and DN. Moreover, the clastogenic effect of CP was reduced in pretreatment of the animals with AC in a dose of 1 mg/kg, and that of DN when it was combined with AC in a dose of 0.1 mg/kg for 5 days and in pretreatment of the animals with AC in a dose of 1.0 mg/kg.
Durnev
A D
AD
Tiurina
L S
LS
Guseva
N V
NV
Oreshchenko
A V
AV
Seredinin
S B
SB
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects*; D001854:Bone Marrow Cells; D002338:Carotenoids / Q000008:administration & dosage / Q000494:pharmacology*; D002869:Chromosome Aberrations / Q000235:genetics*; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000633:toxicity*; D004347:Drug Interactions; D007274:Injections, Intraperitoneal; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009153:Mutagens / Q000633:toxicity*; D009154:Mutation / Q000187:drug effects / Q000235:genetics; D011810:Quinoxalines / Q000008:administration & dosage / Q000633:toxicity*
D009153:Mutagens; D011810:Quinoxalines; C001077:dioxidine; D002338:Carotenoids; D003520:Cyclophosphamide