[The effect of trophoblast-specific beta 1-glycoprotein and oncoprecipitin A on the growth and morphology of HeLa-M tumor cells].
Pregnancy-specific beta 1-glycoprotein (PS-1), one of a large family in oncofetal antigens, and oncoprecipitin A, a specific glycoprotein isolated from ascidians, have been shown to reduce cell proliferative activity in HeLa-M cells but almost not to change RNA synthesis. Using scanning electron microscopy, distinct surface transductions in the studied cells were demonstrated. After the incubation of cells with oncoprecipitin A, cell shape alteration and intensive cell spreading were observed. The treatment of tumor cells with PS-1 changed cell shape and essentially reduced cell contacts, as compared to control cells. The changes in cell surface and shape correlated with essential reorganization of actin microfilaments. The use of substances influencing the growth and adhesive characteristics of tumor cells may help in understanding mechanisms of cell transformation.
Odintsova
N A
NA
Moroz
S V
SV
Ermak
A V
AV
Pavlenko
A F
AF
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D047630:Depsipeptides; D006367:HeLa Cells / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure; D006801:Humans; D008855:Microscopy, Electron, Scanning; D010456:Peptides, Cyclic / Q000494:pharmacology*; D011268:Pregnancy-Specific beta 1-Glycoproteins / Q000494:pharmacology*; D012334:RNA, Neoplasm / Q000096:biosynthesis / Q000187:drug effects; D014407:Tumor Cells, Cultured; D014561:Urochordata
D000970:Antineoplastic Agents; D047630:Depsipeptides; D010456:Peptides, Cyclic; D011268:Pregnancy-Specific beta 1-Glycoproteins; D012334:RNA, Neoplasm; C030051:didemnins