title: Verapamil is not an antidepressant in patients resistant to tricyclic antidepressants.
abstract: The effects of a calcium channel blocker (verapamil, 160-320 mg/day for 4 weeks) were studied in seven unipolar major-depressed patients resistant to treatment with tricyclic antidepressants. This regimen of verapamil did not alter either the Hamilton rating scales for depression and anxiety or the Beck depression inventory score in these patients. Thus, verapamil appears devoid of antidepressant properties in patients resistant to tricyclic antidepressants.
authors.affiliation: Ness-Ziona Mental Health Center, Sackler Faculty of Medicine, Tel-Aviv University, Israel.
authors.forename: S
authors.initials: S
authors.lastname: Adlersberg
authors.forename: P
authors.initials: P
authors.lastname: Toren
authors.forename: R
authors.initials: R
authors.lastname: Mester
authors.forename: M
authors.initials: M
authors.lastname: Rehavi
authors.forename: P
authors.initials: P
authors.lastname: Skolnick
authors.forename: A
authors.initials: A
authors.lastname: Weizman
mesh_terms: D000328:Adult; D000929:Antidepressive Agents, Tricyclic / Q000627:therapeutic use; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D003866:Depressive Disorder / Q000188:drug therapy*; D004351:Drug Resistance; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D014700:Verapamil / Q000627:therapeutic use*
chemical_list: D000929:Antidepressive Agents, Tricyclic; D002121:Calcium Channel Blockers; D014700:Verapamil