title: Massive nitrogen loss in critical surgical illness: effect on cardiac mass and function.
abstract: OBJECTIVE
  The authors measured cardiac mass and function to determine whether these changed in patients who were critically ill who were losing large amounts of nitrogen from the body.
  
  
  BACKGROUND
  The large losses of body nitrogen that occur in patients with protein-energy malnutrition are associated with a loss of cardiac mass and function. It is not known if this also occurs in patients who were critically ill who are losing massive amounts of nitrogen.
  
  
  METHODS
  Once hemodynamically stable, 13 patients who were critically ill underwent sequential measurements of left ventricular mass (LVM) and function, total body nitrogen (TBN), total body potassium, body weight, fat-free mass, and limb muscle mass.
  
  
  RESULTS
  Over a 21-day study period, there was no change in LVM or function despite falls of 14% and 21% in TBN and total body potassium, respectively, a 21% fall in limb muscle mass, and a deterioration in skeletal muscle function by approximately 40%.
  
  
  CONCLUSIONS
  In patients who were critically ill, cardiac mass does not decrease and function does not deteriorate after hemodynamic stability has been achieved despite massive losses of protein from the body.
authors.affiliation: University Department of Surgery, Auckland Hospital, New Zealand.
authors.forename: A A
authors.initials: AA
authors.lastname: Hill
authors.forename: L D
authors.initials: LD
authors.lastname: Plank
authors.forename: P J
authors.initials: PJ
authors.lastname: Finn
authors.forename: G A
authors.initials: GA
authors.lastname: Whalley
authors.forename: N
authors.initials: N
authors.lastname: Sharpe
authors.forename: M A
authors.initials: MA
authors.lastname: Clark
authors.forename: G L
authors.initials: GL
authors.lastname: Hill
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001835:Body Weight; D016638:Critical Illness; D005260:Female; D006352:Heart Ventricles / Q000473:pathology*; D006801:Humans; D008297:Male; D009584:Nitrogen / Q000378:metabolism*; D009929:Organ Size; D011183:Postoperative Complications / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology*; D011188:Potassium / Q000378:metabolism; D016276:Ventricular Function / Q000502:physiology*
chemical_list: D009584:Nitrogen; D011188:Potassium