[Lipid peroxidation in patients with multiple sclerosis].
Questions of lipid metabolism in patients with multiple sclerosis are considered in the light of biomembrane (myelin) pathology. The results of of the study of the lipids fatty acids spectrum in the blood plasma and the secondary product of their spontaneous and NADPhH-dependent peroxidation, malonic dialdehyde, are stated. The dependence of changes in saturation of fatty acids spectrum and dialdehyde concentrations on the stage and heaviness of the multiple sclerosis is shown. Certain dynamics of lipid metabolism indices as a result of treatment was found. The authors also give some recommendations as to the use of drugs at various stages of the disease.
Sokolova
L I
LI
Iurzhenko
N M
NM
Briuzhina
T S
TS
D000328:Adult; D018450:Disease Progression; D005227:Fatty Acids / Q000097:blood; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000097:blood* / Q000209:etiology; D018709:Statistics, Nonparametric
D005227:Fatty Acids; D008315:Malondialdehyde