Recovering optic neuritis during systemic cisplatin and carboplatin chemotherapy.
BACKGROUND
We describe bilateral optic neuropathy in a patient affected by ovarian carcinoma treated with cis-platin 160 mg/m2 and carboplatin, 640 mg/m2. The patient was followed for 1 year, when recovery appeared. The few previous descriptions of CDDP optic nerve toxicity did not report recovery.


METHODS
Computerized visual field, visual evoked potentials, pattern electroretinograms, full field flash electroretinograms were recorded during follow-up.


RESULTS
Optic neuritis appeared 13 weeks after cis-platin discontinuation, with right eye central scotoma; 2 days later the patient became bilaterally blind. Visual evoked potentials were initially absent, reappeared, with delayed latencies to left eye stimuli at 6 months, in both eyes at 9 months. At 1 year delayed VEPs were recorded with right eye stimuli, normal VEPs were recorded for left eye.


CONCLUSIONS
Cis-platin can induce delayed optic neuritis, that can recover in 1 year.
Caraceni
A
A
Divisione di Terapia del Dolore e Cure Palliative, Istituto Nazionale Tumori, Milano, Italy.
Martini
C
C
Spatti
G
G
Thomas
A
A
Onofrj
M
M
D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D016190:Carboplatin / Q000008:administration & dosage / Q000009:adverse effects*; D017024:Chemotherapy, Adjuvant; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects*; D018283:Cystadenocarcinoma, Papillary / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005074:Evoked Potentials, Visual / Q000187:drug effects* / Q000502:physiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D009900:Optic Nerve / Q000187:drug effects / Q000503:physiopathology; D009902:Optic Neuritis / Q000139:chemically induced* / Q000503:physiopathology; D010051:Ovarian Neoplasms / Q000188:drug therapy*; D012075:Remission, Spontaneous; D013375:Substance Withdrawal Syndrome / Q000175:diagnosis / Q000503:physiopathology; D014792:Visual Acuity / Q000187:drug effects / Q000502:physiology
D000970:Antineoplastic Agents; D016190:Carboplatin; D002945:Cisplatin