title: Grey matter correlates of syndromes in schizophrenia. A semi-automated analysis of structural magnetic resonance images.
abstract: BACKGROUND
  Symptoms in schizophrenia cluster into syndromes, each of which may be associated with a particular pattern of cerebral blood flow. We sought to investigate whether these syndromes are also related to neuroanatomical changes.
  
  
  METHODS
  A semi-automated method was used to examine structural magnetic resonance images in 12 patients with schizophrenia. The relationship between the relative regional grey matter volume and ratings of the syndromes of psychomotor poverty, disorganisation and reality distortion was investigated.
  
  
  RESULTS
  There was a significant negative correlation between psychomotor poverty score and the relative volume of the left ventro-medial prefrontal grey matter, and a significant positive correlation between disorganisation and the relative volumes of the hippocampus, and the parahippocampal/fusiform gyrus bilaterally.
  
  
  CONCLUSIONS
  The correlation between psychomotor poverty and left prefrontal grey matter volume resembles that previously seen with prefrontal blood flow in the same patient, suggesting that this functional abnormality is related to an underlying anatomical change.
authors.affiliation: Institute of Psychiatry, De Crespigny Park, London.
authors.forename: S E
authors.initials: SE
authors.lastname: Chua
authors.forename: I C
authors.initials: IC
authors.lastname: Wright
authors.forename: J B
authors.initials: JB
authors.lastname: Poline
authors.forename: P F
authors.initials: PF
authors.lastname: Liddle
authors.forename: R M
authors.initials: RM
authors.lastname: Murray
authors.forename: R S
authors.initials: RS
authors.lastname: Frackowiak
authors.forename: K J
authors.initials: KJ
authors.lastname: Friston
authors.forename: P K
authors.initials: PK
authors.lastname: McGuire
mesh_terms: D000328:Adult; D001927:Brain Diseases / Q000000981:diagnostic imaging / Q000473:pathology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D011596:Psychomotor Disorders / Q000523:psychology; D012559:Schizophrenia / Q000000981:diagnostic imaging / Q000473:pathology*; D013577:Syndrome; D014055:Tomography, Emission-Computed