title: Temperature compensation of circadian rhythms: control of the period in a model for circadian oscillations of the per protein in Drosophila.
abstract: The factors affecting the period are examined in a model for circadian oscillations of the period protein (PER) in Drosophila. The model for the circadian clock is based on multiple phosphorylation of PER and on the negative feedback exerted by PER on the transcription of the period (per) gene. The results are used to address the possible bases of the relative invariance of the period of oscillations with respect to temperature. Such a phenomenon, referred to as temperature compensation, represents one of the most conspicuous properties of circadian rhythms.
authors.affiliation: Unité de Chronobiologie Théorique, Faculté des Sciences, Université Libre de Bruxelles, Belgium.
authors.forename: J C
authors.initials: JC
authors.lastname: Leloup
authors.forename: A
authors.initials: A
authors.lastname: Goldbeter
mesh_terms: D000818:Animals; D002940:Circadian Rhythm; D004330:Drosophila / Q000502:physiology*; D029721:Drosophila Proteins; D005786:Gene Expression Regulation; D007700:Kinetics; D008954:Models, Biological; D009687:Nuclear Proteins / Q000096:biosynthesis*; D056950:Period Circadian Proteins; D013696:Temperature; D014158:Transcription, Genetic
chemical_list: D029721:Drosophila Proteins; D009687:Nuclear Proteins; C539040:PER protein, Drosophila; D056950:Period Circadian Proteins