The apparent antipsychotic action of the 5-HT2a receptor antagonist M100907 in a mouse model of schizophrenia is counteracted by ritanserin. (Rapid communication).
The apparent antipsychotic action of the selective 5-HT2a receptor antagonist M100907 in MK-801-treated NMRI mice was shown to be markedly counteracted by the 5-HT2a/2c receptor antagonist ritanserin. The mechanism of action and potential implications are discussed.
Martin
P
P
Department of Pharmacology, Göteborg University, Sweden.
Waters
N
N
Carlsson
A
A
Carlsson
M L
ML
D000818:Animals; D014150:Antipsychotic Agents / Q000037:antagonists & inhibitors* / Q000494:pharmacology*; D016291:Dizocilpine Maleate; D018691:Excitatory Amino Acid Antagonists; D005464:Fluorobenzenes / Q000037:antagonists & inhibitors / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009043:Motor Activity / Q000187:drug effects; D010880:Piperidines / Q000037:antagonists & inhibitors / Q000627:therapeutic use*; D016713:Ritanserin / Q000494:pharmacology*; D012559:Schizophrenia / Q000139:chemically induced / Q000503:physiopathology*; D012702:Serotonin Antagonists / Q000494:pharmacology*
D014150:Antipsychotic Agents; D018691:Excitatory Amino Acid Antagonists; D005464:Fluorobenzenes; D010880:Piperidines; D012702:Serotonin Antagonists; D016713:Ritanserin; D016291:Dizocilpine Maleate; C079049:volinanserin