title: Comparison of oral sodium compounds for the correction of acidosis.
abstract: Three Na compounds were tested to determine which was best able to treat metabolic acidosis in dairy cows. Metabolic acidosis was induced in test cows by feeding a diet that was high in anions for 7 d before the administration of treatment on d 8. The orally administered treatments were equivalent amounts of Na in the form of NaCl (208.6 g), NaHCO3 (300 g), or Na propionate (343 g). The initiation of oral treatment was designated as time 0, and blood samples were taken 15 min before treatment, immediately before treatment, and 15, 30, 45, 60, 90, 120, 180, 240, 300, and 360 min after treatment. Before treatment, all cows were in a state of metabolic acidosis as was evidenced by low blood pH, low HCO3 concentrations, and high plasma Cl concentrations. After treatment, blood pH and HCO3 were markedly higher for cows receiving NaHCO3 and Na propionate but not for cows receiving NaCl. We concluded that orally administered NaHCO3 and Na propionate were equally effective in correcting the acid-base balance of blood, as was predicted by the strong ion difference theory of acid-base physiology. Sodium propionate may be considered a more effective treatment of metabolic acidosis in diseases such as ketosis because the added propionate can serve as a source of glucose for the cow.
authors.affiliation: Department of Animal Science, Iowa State University, Ames 50011, USA.
authors.forename: D R
authors.initials: DR
authors.lastname: Bigner
authors.forename: J P
authors.initials: JP
authors.lastname: Goff
authors.forename: M A
authors.initials: MA
authors.lastname: Faust
authors.forename: H D
authors.initials: HD
authors.lastname: Tyler
authors.forename: R L
authors.initials: RL
authors.lastname: Horst
mesh_terms: D000138:Acidosis / Q000188:drug therapy / Q000662:veterinary*; D000284:Administration, Oral; D000818:Animals; D001639:Bicarbonates / Q000097:blood; D001769:Blood; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy*; D002712:Chlorides / Q000097:blood; D005260:Female; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D011422:Propionates / Q000008:administration & dosage / Q000627:therapeutic use*; D017693:Sodium Bicarbonate / Q000008:administration & dosage / Q000627:therapeutic use*; D012965:Sodium Chloride / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D001639:Bicarbonates; D002712:Chlorides; D011422:Propionates; D012965:Sodium Chloride; D017693:Sodium Bicarbonate; C514135:sodium propionate; C029658:propionic acid