title: Plasma interleukin-8, interleukin-10, and E-selectin levels in neutropenic and non-neutropenic bacteremic patients.
abstract: Plasma interleukin-8 (IL-8) interleukin-10 (IL-10), and E-selectin concentrations were studied in 39 neutropenic and 30 non-neutropenic bacteremic patients; 54 nonbacteremic patients were analyzed as controls. Interleukin-8 concentrations were significantly higher in neutropenic than in non-neutropenic bacteremic patients (median 475 vs. 0 pg/ml, p < 0.0001). Median IL-8 and IL-10 levels were higher in bacteremic than in non-bacteremic patients (330 vs. 0 pg/ml, p < 0.0001 and 20 vs. 0 pg/ml, p = 0.04, respectively). In contrast, concentrations of IL-10 were similar in neutropenic and non-neutropenic patients. Median levels of E-selectin were not increased in any of the patient groups. Neutropenic bacteremic patients showed significantly lower concentrations of E-selectin than did non-neutropenic bacteremic patients (p < 0.0001). In conclusion, neutropenic bacteremic patients had significantly higher concentrations of IL-8 than non-neutropenic bacteremic patients. Levels of IL-10 were higher in bacteremic than in nonbacteremic patients, but neutropenic and non-neutropenic patients had similar levels of IL-10. Increased levels of E-selectin were not found in any of the patient groups, although neutropenic patients with bacteremia had lower concentrations than did non-neutropenic patients.
authors.affiliation: Department of Surgery/Intensive Care Unit, Helsinki University Central Hospital, Finland.
authors.forename: M
authors.initials: M
authors.lastname: Hynninen
authors.forename: M
authors.initials: M
authors.lastname: Valtonen
authors.forename: M
authors.initials: M
authors.lastname: Vaara
authors.forename: H
authors.initials: H
authors.lastname: Markkanen
authors.forename: P
authors.initials: P
authors.lastname: Kuusela
authors.forename: H
authors.initials: H
authors.lastname: Saxen
authors.forename: O
authors.initials: O
authors.lastname: Takkunen
mesh_terms: D000328:Adult; D000368:Aged; D016470:Bacteremia / Q000097:blood* / Q000145:classification / Q000150:complications / Q000382:microbiology; D015415:Biomarkers / Q000097:blood; D016009:Chi-Square Distribution; D019040:E-Selectin / Q000097:blood*; D005260:Female; D006090:Gram-Negative Bacteria / Q000302:isolation & purification; D006094:Gram-Positive Bacteria / Q000302:isolation & purification; D006801:Humans; D007124:Immunoenzyme Techniques; D016753:Interleukin-10 / Q000097:blood*; D016209:Interleukin-8 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009503:Neutropenia / Q000097:blood* / Q000209:etiology; D012680:Sensitivity and Specificity
chemical_list: D015415:Biomarkers; D019040:E-Selectin; D016209:Interleukin-8; D016753:Interleukin-10