title: The Virginia Twin Study of Adolescent Behavioral Development. Influences of age, sex, and impairment on rates of disorder.
abstract: BACKGROUND
  The Virginia Twin Study of Adolescent Behavioral Development is a cohort-longitudinal epidemiological study that uses the genetic twin design to study the development and maintenance of child psychiatric disorders. We determined the rates of DSM-III-R disorders, disorders with impairment, and age, sex, and comorbidity effects.
  
  
  METHODS
  Families of 2762 white twins aged 8 to 16 years participated. Twins and their parents were asked systematically about risk factors and current psychiatric symptoms by means of investigator-based psychiatric interviews and questionnaires. The DSM-III-R diagnoses were made for major depressive disorder, separation anxiety, overanxious disorder, simple phobia, social phobia, agoraphobia, oppositional defiant disorder, conduct disorder, and attention deficit hyperactivity disorder.
  
  
  RESULTS
  The 3-month point prevalence for any DSM-III-R disorders was 413 per 1000, and that for disorders with associated impairment was 142 per 1000. Emotional disorders with impairment occurred in 89 per 1000, with girls being more commonly affected; behavioral disorders had a prevalence of 71 per 1000, with boys being more frequently affected. The proportion with disorder who also had functional impairment varied across disorders; anxiety and phobic disorders were particularly likely not to be accompanied by impairment. Rates of emotional and behavioral disorders increased over the age range. There was extensive comorbidity among disorders.
  
  
  CONCLUSIONS
  The prevalence rates and patterns of findings from this study of twins are consistent with those of other epidemiological studies, supporting previous findings of few differences in rates of psychiatric disorder between twins and singletons. The importance of including measures of functional impairment is evident by its effect on rates of disorder and patterns of comorbidity.
authors.affiliation: Medical Research Council Child Psychiatry Unit, Institute of Psychiatry, London, England.
authors.forename: E
authors.initials: E
authors.lastname: Simonoff
authors.forename: A
authors.initials: A
authors.lastname: Pickles
authors.forename: J M
authors.initials: JM
authors.lastname: Meyer
authors.forename: J L
authors.initials: JL
authors.lastname: Silberg
authors.forename: H H
authors.initials: HH
authors.lastname: Maes
authors.forename: R
authors.initials: R
authors.lastname: Loeber
authors.forename: M
authors.initials: M
authors.lastname: Rutter
authors.forename: J K
authors.initials: JK
authors.lastname: Hewitt
authors.forename: L J
authors.initials: LJ
authors.lastname: Eaves
mesh_terms: D000293:Adolescent; D000367:Age Factors; D001008:Anxiety Disorders / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics; D001010:Anxiety, Separation / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics; D002648:Child; D002653:Child Behavior Disorders / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics; D015331:Cohort Studies; D015897:Comorbidity; D003866:Depressive Disorder / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics; D004200:Diseases in Twins / Q000175:diagnosis / Q000453:epidemiology* / Q000235:genetics; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D001523:Mental Disorders / Q000175:diagnosis / Q000453:epidemiology* / Q000235:genetics; D010290:Parents; D010698:Phobic Disorders / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics; D015995:Prevalence; D011569:Psychiatric Status Rating Scales / Q000706:statistics & numerical data; D012737:Sex Factors; D014768:Virginia / Q000453:epidemiology