Intravenous administration of haloperidol to healthy volunteers: lack of subjective effects but clear objective effects.
Healthy volunteers who received i.v. injections of either saline or haloperidol (0.5 or 1.0 mg) made visual analogue scale ratings of subjective mood, tension, shakiness and the global feeling of having received an active drug. The subjective ratings of volunteers who received haloperidol did not differ, overall, from those who received saline. In contrast, the drug caused clear objective changes in several psychological tests. I.v. administration of low doses of haloperidol may permit double-blind testing of the psychological actions of haloperidol in healthy volunteers.
Williams
J H
JH
Department of Pharmacology, University of Oxford, UK.
Wellman
N A
NA
Geaney
D P
DP
Rawlins
J N
JN
Feldon
J
J
Cowen
P J
PJ
D000339:Affect / Q000187:drug effects*; D014150:Antipsychotic Agents / Q000494:pharmacology*; D001288:Attention / Q000187:drug effects*; D001794:Blood Pressure / Q000187:drug effects*; D004311:Double-Blind Method; D005260:Female; D006220:Haloperidol / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D007275:Injections, Intravenous; D008297:Male
D014150:Antipsychotic Agents; D006220:Haloperidol