title: Synergistic activities of clarithromycin and pyrazinamide against Mycobacterium tuberculosis in human macrophages.
abstract: The combination of clarithromycin and pyrazinamide was found to be synergistic against Mycobacterium tuberculosis in human macrophages. MICs were four- to eightfold lower for this combination than they were for either drug alone. Clarithromycin and rifampin, however, had only an additive effect.
authors.affiliation: Charles R. Drew University of Medicine and Science, Los Angeles, California 90059, USA.
authors.forename: N
authors.initials: N
authors.lastname: Mor
authors.forename: A
authors.initials: A
authors.lastname: Esfandiari
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000904:Antibiotics, Antitubercular / Q000494:pharmacology; D000995:Antitubercular Agents / Q000494:pharmacology*; D002478:Cells, Cultured; D017291:Clarithromycin / Q000494:pharmacology*; D004357:Drug Synergism; D006801:Humans; D008264:Macrophages / Q000187:drug effects / Q000382:microbiology*; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D011718:Pyrazinamide / Q000494:pharmacology*; D012293:Rifampin / Q000494:pharmacology; D014376:Tuberculosis / Q000097:blood / Q000188:drug therapy
chemical_list: D000900:Anti-Bacterial Agents; D000904:Antibiotics, Antitubercular; D000995:Antitubercular Agents; D011718:Pyrazinamide; D017291:Clarithromycin; D012293:Rifampin