Comparison of postantibiotic effects of imipenem and netilmicin alone and in combination against Pseudomonas aeruginosa.
Imipenem (CAS 64221-86-9) as well as netilmicin (CAS 56391-57-2) at suprainhibitory concentrations induced the postantibiotic effects against three P. aeruginosa strains. Imipenem (2 x or 4 x minimal inhibitory concentration (MIC)) showed postantibiotic effects in the range of 0.3-1.6 h and 0.9-4.0 h. Netilmicin at the same concentrations produced postantibiotic effects of 3.0-3.8 h and 3.5-4.5 h. Postantibiotic effects manifested by imipenem (2 x or 4 x MIC) + netilmicin (2 x MIC) combination were somewhat longer (in the range of 4.6-4.9 h and 5.8-7.4 h) than the mathematical sum of postantibiotic effects induced by drugs alone (in the range of 4.1-4.7 h and 4.7-7.0 h).
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Institute of Preventive and Clinical Medicine, Bratislava, Slovak Republic.
D015780:Carbapenems / Q000494:pharmacology*; D004359:Drug Therapy, Combination / Q000494:pharmacology*; D005839:Gentamicins / Q000494:pharmacology*; D006801:Humans; D015378:Imipenem / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009428:Netilmicin / Q000494:pharmacology*; D011552:Pseudomonas Infections / Q000382:microbiology; D011550:Pseudomonas aeruginosa / Q000187:drug effects*; D014552:Urinary Tract Infections / Q000382:microbiology
D015780:Carbapenems; D005839:Gentamicins; D009428:Netilmicin; D015378:Imipenem