Isolation and characterization of the gene encoding the type 5 mouse (Mus musculus) somatostatin receptor (msst5).
We have isolated and determined the nucleotide sequence of the gene for the fifth mouse somatostatin receptor (msst5). The gene can encode a protein of 363 amino acid residues (aa). The deduced aa sequence of msst5 has 97 and 81% identity to the rat and human sst5 respectively, while it has lower identities with the four other mouse sst(n)s (msst1 -- 48%, msst2 -- 55%, msst3 -- 56%, and msst4 -- 52%). We show that msst5 is expressed in brain but not in liver, heart, spleen, or kidney of the adult mouse.
Lublin
A L
AL
Unit on Molecular Genetics, NSB, NIMH, Bethesda, MD 20892, USA.
Diehl
N L
NL
Hochgeschwender
U
U
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D003001:Cloning, Molecular; D017124:Conserved Sequence; D006801:Humans; D051379:Mice; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction / Q000379:methods; D051381:Rats; D017481:Receptors, Somatostatin / Q000235:genetics* / Q000378:metabolism*; D017421:Sequence Analysis; D017386:Sequence Homology, Amino Acid; D012689:Sequence Homology, Nucleic Acid; D014018:Tissue Distribution
D017481:Receptors, Somatostatin; C094573:somatostatin receptor 5