Excitotoxic lesions of histaminergic neurons by excitatory amino acid agonists in the rat brain.
Excitotoxic lesions of histaminergic (HA) neurons in the rat hypothalamus were observed by the injection of ibotenate and N-methyl-D-aspartate (NMDA) while kainate, quisqualate and quinolinate had no significant effects on HA neurons. An NMDA selective antagonist, 2-amino-5-phosphonopentanoic acid, was able to block the toxic effects of both NMDA and ibotenate almost completely, but kynurenate was a weaker inhibitor of ibotenate or NMDA-induced neurotoxicity. These results suggest that there exists an ibotenate-sensitive and quinolinate-insensitive NMDA receptor subtype on HA neurons.
Yanai
K
K
Department of Pharmacology I, Tohoku University School of Medicine, Sendai, Japan.
Zhao
X L
XL
Watanabe
T
T
D000818:Animals; D001921:Brain / Q000187:drug effects*; D018690:Excitatory Amino Acid Agonists / Q000494:pharmacology*; D006632:Histamine / Q000378:metabolism*; D007031:Hypothalamus / Q000187:drug effects; D007051:Ibotenic Acid / Q000494:pharmacology; D008297:Male; D016202:N-Methylaspartate / Q000494:pharmacology; D009474:Neurons / Q000187:drug effects*; D009498:Neurotoxins / Q000494:pharmacology*; D016318:Quisqualic Acid / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar
D018690:Excitatory Amino Acid Agonists; D009498:Neurotoxins; D007051:Ibotenic Acid; D016202:N-Methylaspartate; D006632:Histamine; D016318:Quisqualic Acid