Differential effect of sensitizing regimen on induction of Fos-protein and locomotor activity elicited by apomorphine in rats.
At doses that elicit behavioral activation, apomorphine does not induce Fos-protein in the nucleus accumbens of control animals but does under conditions of denervation supersensitivity. The purpose of this study was to determine whether apomorphine induces Fos-protein in animals sensitized by repeated treatment with apomorphine and whether the magnitude of such induction parallels the magnitude of behavioral response observed after different sensitizing paradigms. Apomorphine did induce Fos-protein expression in animals pretreated with apomorphine; however, the rats showing highest levels of induction were not those showing the largest behavioral responses.
Laudrup
P
P
Ohio State University, College of Pharmacy, Columbus 43210, USA.
Dalia
A
A
Uretsky
N J
NJ
Wallace
L J
LJ
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology*; D018491:Dopamine Agonists / Q000494:pharmacology*; D008124:Locomotion / Q000187:drug effects*; D008297:Male; D009714:Nucleus Accumbens / Q000187:drug effects / Q000378:metabolism; D016760:Proto-Oncogene Proteins c-fos / Q000096:biosynthesis / Q000187:drug effects*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012680:Sensitivity and Specificity
D018491:Dopamine Agonists; D016760:Proto-Oncogene Proteins c-fos; D001058:Apomorphine