title: The smaller size of the 'coeliac iceberg' in adults.
abstract: BACKGROUND
  Since it has been ascertained that the prevalence of coeliac disease in the general paediatric population is 3.3 per 1000, we decided to evaluate this prevalence in the general adult population.
  
  
  METHODS
  Two thousand two hundred and thirty-seven adult subjects aged 20-87 years, representative of a population with sociodemographic characteristics typical of Western European countries with regard to sex and age, were studied. In all serum IgA antiendomysial antibodies (EMA) were searched for, and all patients who turned out to be positive underwent intestinal biopsy.
  
  
  RESULTS
  Four symptomless subjects aged between 20 and 39 years proved positive at the IgA EMA screening. This intestinal biopsy confirmed coeliac disease in all of them. The prevalence in our study group was, therefore, 1.8 per 1000.
  
  
  CONCLUSIONS
  This study shows that the size of the submerged part of the 'coeliac iceberg' is perhaps smaller in the adult population and suggests a linear trend towards a lower coeliac disease prevalence as age increases.
authors.affiliation: Dept. of Internal Medicine, University of L'Aquila, Italy.
authors.forename: G R
authors.initials: GR
authors.lastname: Corazza
authors.forename: M L
authors.initials: ML
authors.lastname: Andreani
authors.forename: F
authors.initials: F
authors.lastname: Biagi
authors.forename: G
authors.initials: G
authors.lastname: Corrao
authors.forename: S
authors.initials: S
authors.lastname: Pretolani
authors.forename: G
authors.initials: G
authors.lastname: Giulianelli
authors.forename: G
authors.initials: G
authors.lastname: Ghironzi
authors.forename: G
authors.initials: G
authors.lastname: Gasbarrini
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D002446:Celiac Disease / Q000453:epidemiology* / Q000276:immunology / Q000473:pathology; D005260:Female; D019084:Fluorescent Antibody Technique, Indirect; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D008297:Male; D008875:Middle Aged; D016012:Poisson Distribution; D015995:Prevalence
chemical_list: D007070:Immunoglobulin A