Rel/NF-kappa B transcription factors and the control of apoptosis.
The process of apoptosis is used to eliminate unwanted cells from a wide variety of organisms. Various extracellular signals, often converging in common intracellular pathways, can induce apoptosis in a cell-type-specific fashion. Recent work from several laboratories has demonstrated that Rel/NF-kappa B transcription factors regulate apoptosis in many cell types. In most cells, Rel/NF-kappa B transcription factors appear to mediate survival signals that protect cells from apoptosis; however, under some circumstances, activation of these factors may also promote apoptosis.
Sonenshein
G E
GE
Department of Biochemistry, Boston University School of Medicine, MA 02118, USA.
D000818:Animals; D017209:Apoptosis / Q000235:genetics*; D001402:B-Lymphocytes; D019013:CD40 Antigens; D002470:Cell Survival; D005809:Genes, Regulator; D006801:Humans; D008024:Ligands; D016393:Lymphoma, B-Cell; D016328:NF-kappa B / Q000235:genetics*; D009857:Oncogenes / Q000235:genetics*; D011518:Proto-Oncogene Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D051841:Transcription Factor RelB; D014157:Transcription Factors; D016212:Transforming Growth Factor beta; D014409:Tumor Necrosis Factor-alpha; D051020:bcl-X Protein
C494811:BCL2L1 protein, human; D019013:CD40 Antigens; D008024:Ligands; D016328:NF-kappa B; D011518:Proto-Oncogene Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; C497593:RELB protein, human; D014157:Transcription Factors; D016212:Transforming Growth Factor beta; D014409:Tumor Necrosis Factor-alpha; D051020:bcl-X Protein; D051841:Transcription Factor RelB