title: Hemolysis, elevated liver enzymes, and low platelets syndrome associated with primary anti-phospholipid antibody syndrome.
abstract: A 28-year-old woman with a history of a spontaneous abortion developed thrombocytopenia, Coombs-negative hemolytic anemia, and liver dysfunction at the sixteenth week of pregnancy. These findings were compatible with hemolysis, elevated liver enzymes, and low platelets (HELLP) syndrome (hemolysis, elevated liver enzymes, and low platelet counts). Moreover, serum anti-phospholipid antibodies were positive, suggesting the association of anti-phospholipid antibody syndrome. An artificial abortion, anti-coagulation therapy, and plasma exchange were performed concomitantly with corticosteroid therapy. She responded to the therapy, a remission was obtained. Anti-phospholipid antibodies may play a role in the pathogenesis of HELLP syndrome.
authors.affiliation: Department of Internal Medicine, Musashino Red Cross Hospital, Tokyo.
authors.forename: K
authors.initials: K
authors.lastname: Nagayama
authors.forename: N
authors.initials: N
authors.lastname: Izumi
authors.forename: Y
authors.initials: Y
authors.lastname: Miyasaka
authors.forename: K
authors.initials: K
authors.lastname: Saito
authors.forename: K
authors.initials: K
authors.lastname: Ono
authors.forename: O
authors.initials: O
authors.lastname: Noguchi
authors.forename: Y
authors.initials: Y
authors.lastname: Hoshino
authors.forename: M
authors.initials: M
authors.lastname: Uchihara
authors.forename: S
authors.initials: S
authors.lastname: Miyake
authors.forename: N
authors.initials: N
authors.lastname: Enomoto
authors.forename: Y
authors.initials: Y
authors.lastname: Tanaka
authors.forename: F
authors.initials: F
authors.lastname: Marumo
authors.forename: C
authors.initials: C
authors.lastname: Sato
mesh_terms: D000028:Abortion, Induced; D000328:Adult; D000925:Anticoagulants / Q000627:therapeutic use; D016736:Antiphospholipid Syndrome / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D005260:Female; D017359:HELLP Syndrome / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D006801:Humans; D010951:Plasma Exchange; D011247:Pregnancy
chemical_list: D000925:Anticoagulants