The involvement of 5-HT1B receptors in the inhibitory effects of nitric oxide synthase inhibitor on 2-deoxy-D-glucose-induced hyperphagia in rats.
We found previously that the nitric oxide (NO) synthase inhibitor N(G)-nitro-L-arginine methyl ester (L-NAME) significantly reduced 2-deoxy-D-glucose (2-DG)-induced hyperphagia in rats. To clarify the involvement of 5-HT, we investigated the effects of 5-HT receptor antagonists on inhibitory effects of L-NAME on 2-DG-induced hyperphagia. The effects of L-NAME on 2-DG-induced hyperphagia were inhibited by the 5-HT1B receptor antagonist metergoline. However, the 5-HT2 receptor antagonist ritanserin had no such effect. These results suggest that the anorectic effects of L-NAME may be related to serotonergic mechanisms.
Sugimoto
Y
Y
Department of Pharmacology, Kobe Pharmaceutical University, Japan.
Yamada
J
J
Yoshikawa
T
T
Horisaka
K
K
D000704:Analysis of Variance; D000818:Animals; D003847:Deoxyglucose; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D006963:Hyperphagia / Q000139:chemically induced / Q000188:drug therapy*; D008297:Male; D008711:Metergoline / Q000494:pharmacology; D019331:NG-Nitroarginine Methyl Ester / Q000494:pharmacology*; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors*; D051381:Rats; D017207:Rats, Sprague-Dawley; D011985:Receptors, Serotonin / Q000502:physiology*; D016713:Ritanserin / Q000494:pharmacology; D012702:Serotonin Antagonists / Q000494:pharmacology
D004791:Enzyme Inhibitors; D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D016713:Ritanserin; D008711:Metergoline; D003847:Deoxyglucose; D019001:Nitric Oxide Synthase; D019331:NG-Nitroarginine Methyl Ester