The development of neurobehavioral toxicology in China: the 1994 Hänninen Lecture.
With the rapid growth of industrialization in China, occupational and environmental exposure to chemicals has increased in frequency and in types of chemical exposures. A growing number of Chinese researchers are showing a special interest in exploring the effects of chemicals on the central nervous system. This paper presents a comprehensive review of neurobehavioral toxicology in China. It describes research into the "reference values" of the Neurobehavioral Core Test Battery (NCTB) tests, the development and improvement of the computer-administered Chinese version of the Neurobehavioral Evaluation System (NES-C), and exploration of related biomarkers. On the basis of this research, baseline data for the reference values for six subtests of the NCTB were preliminarily recommended. The upgraded NES-C2 has proven to possess higher stability and validity compared with the previous version, NES-C. Biomarkers derived from the changes in levels of neurotransmitter metabolites might be used as supplementary biomarkers of Pb-induced neurotoxicity.
Liang
Y X
YX
Department of Occupational Health, Shanghai Medical University, Shanghai, 200032, People's Republic of China.
Chen
Z Q
ZQ
Wang
C
C
Tang
H W
HW
Yang
H G
HG
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D001519:Behavior / Q000187:drug effects*; D015415:Biomarkers; D004522:Educational Status; D004785:Environmental Pollutants / Q000506:poisoning*; D005260:Female; D006801:Humans; D007855:Lead Poisoning / Q000378:metabolism / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009420:Nervous System / Q000187:drug effects* / Q000503:physiopathology; D009483:Neuropsychological Tests; D018377:Neurotransmitter Agents / Q000378:metabolism; D012016:Reference Values; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012737:Sex Factors
D015415:Biomarkers; D004785:Environmental Pollutants; D018377:Neurotransmitter Agents