Endocrine regulation of the immune response to influenza virus infection with a metabolite of DHEA-androstenediol.
In these studies the influence of androstenediol on the course of an experimental virus infection was examined. Pretreatment with 320 mg/kg AED protected male mice from lethal influenza virus infection. In addition, AED enhanced antigen-induced trafficking of mononuclear cells into the draining lymph node and augmented antigen-specific activation of helper-T cells, which are important for control of viral pathogenesis. Furthermore, AED prevented the characteristic increase in serum corticosterone noted during influenza A virus infection. Although steroid hormones, at least corticosteroids, typically suppress host immune and inflammatory responses in vivo, these data suggest that AED may function to augment host immune and inflammatory responses in contrast to corticosteroids.
Padgett
D A
DA
Department of Oral Biology, College of Dentistry, The Ohio State University, Columbus 43210, USA.
Loria
R M
RM
Sheridan
J F
JF
D045930:Anabolic Agents / Q000378:metabolism* / Q000494:pharmacology; D015114:Androstenediol / Q000378:metabolism* / Q000494:pharmacology; D000818:Animals; D000917:Antibody Formation / Q000502:physiology; D003345:Corticosterone / Q000097:blood; D003687:Dehydroepiandrosterone / Q000378:metabolism*; D004702:Endocrine Glands / Q000502:physiology*; D007371:Interferon-gamma / Q000378:metabolism; D016753:Interleukin-10 / Q000378:metabolism; D008168:Lung / Q000187:drug effects / Q000473:pathology; D008198:Lymph Nodes / Q000187:drug effects / Q000473:pathology; D008206:Lymphatic Diseases / Q000473:pathology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009976:Orthomyxoviridae Infections / Q000276:immunology* / Q000378:metabolism / Q000401:mortality
D045930:Anabolic Agents; D016753:Interleukin-10; D003687:Dehydroepiandrosterone; D007371:Interferon-gamma; D015114:Androstenediol; D003345:Corticosterone