Effects of an isotonic oral rehydration solution, enriched with glutamine, on fluid and sodium absorption in patients with a short-bowel.
OBJECTIVE
To compare the effects of a standard oral rehydration solution with a polymeric glucose isotonic solution enriched with glutamine on water and sodium absorption in the short bowel.


METHODS
Six patients with high jejunostomy were tested in a random order on 2 consecutive days with the standard solution (20 g/L glucose, 94 mmol/L sodium, 292 mOsm/kg osmolality) and a solution containing maltodextrins (18 g/L Glucidex 12; hydrolysis of 18 g of Glucidex 12 yields 20 g glucose) enriched with 14.6 g/L of glutamine (94 mmol/L sodium, 282 mOsm/kg osmolality). Solutions were administered via a naso-gastric tube at a rate of 2 mL/min. Jejunal effluent for each solution was collected during an 8-h period, after a 14-h equilibrium period.


RESULTS
The net 8-h fluid absorption was not significantly different between the standard solution and the solution with glutamine (333 +/- 195 and 213 +/- 251 mL, respectively (mean +/- S.E.M.)). Net sodium absorption was higher for the standard solution than for the solution with glutamine (15 +/- 15 vs. 2 +/- 20 mmol, P < 0.05). The rate of glucose absorption was not different between the solutions.


CONCLUSIONS
The replacement of glucose by maltodextrins and the addition of glutamine to the standard oral rehydration solution, without changing its sodium content or osmolality, results in a reduction of sodium absorption in the short-bowel syndrome.
Beaugerie
L
L
Department of Gastroenterology, Hôpital Rothschild, Paris, France.
Carbonnel
F
F
Hecketsweiler
B
B
Déchelotte
P
P
Gendre
J P
JP
Cosnes
J
J
D000328:Adult; D000368:Aged; D005260:Female; D005947:Glucose / Q000378:metabolism; D005973:Glutamine / Q000494:pharmacology*; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects; D007421:Intestine, Small / Q000378:metabolism*; D007552:Isotonic Solutions; D007582:Jejunostomy; D008297:Male; D008875:Middle Aged; D011134:Polysaccharides / Q000378:metabolism; D015532:Rehydration Solutions / Q000494:pharmacology*; D012778:Short Bowel Syndrome / Q000378:metabolism*; D012964:Sodium / Q000378:metabolism*
D007552:Isotonic Solutions; D011134:Polysaccharides; D015532:Rehydration Solutions; D005973:Glutamine; C008315:maltodextrin; D012964:Sodium; D005947:Glucose