title: Estimation of foetal brain dose from I-131 in the foetal thyroid.
abstract: The ingestion of I-131 by pregnant women can have consequences for the developing foetus, in particular brain function. As the foetal thyroid accumulates iodine from the twelfth week of gestation onwards, the determination of foetal brain dose resulting from such I-131 accumulation is essential. Normal dosimetric methods fail to treat the case of foetus. Using an approximation method based on the MIRD approach, a foetal dose estimation scheme is developed to allow the determination of foetal brain dose from foetal thyroid irradiation. Dose values are obtained for the foetus based on the maternal intake of I-131. It was found that the choice of biokinetic model for the mother/foetus has a large impact on the determined dose estimate.
authors.affiliation: Medical Physics and Bioengineering Department, St James's Hospital, Dublin, Ireland.
authors.forename: N J
authors.initials: NJ
authors.lastname: O'Hare
authors.forename: P
authors.initials: P
authors.lastname: Gilligan
authors.forename: D
authors.initials: D
authors.lastname: Murphy
authors.forename: J F
authors.initials: JF
authors.lastname: Malone
mesh_terms: D000328:Adult; D055592:Biophysical Phenomena; D001703:Biophysics; D001921:Brain / Q000528:radiation effects*; D005260:Female; D005333:Fetus / Q000528:radiation effects*; D005865:Gestational Age; D006801:Humans; D007457:Iodine Radioisotopes / Q000008:administration & dosage / Q000009:adverse effects* / Q000493:pharmacokinetics; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D011829:Radiation Dosage; D018788:Radioactive Hazard Release; D011874:Radiometry / Q000379:methods; D013961:Thyroid Gland / Q000528:radiation effects*
chemical_list: D007457:Iodine Radioisotopes