title: A 23-year-old patient with neurofibromatosis associated with acute myocardial infarction, vasospasm and a coronary artery ectasis.
abstract: We treated a 23-year-old male with neurofibromatosis with acute myocardial infarction. Cardiac catheterization revealed severe organic stenosis in the left anterior descending artery, an ectasic left circumflex artery and a small right coronary artery. Percutaneous transluminal coronary angioplasty (PTCA) was performed on the stenosis. In follow-up catheterizations, intracoronary administration of ergometrine induced vasospasm of the left coronary artery including at the PTCA site. An I 123 metaiodobenzylguanidine (MIBG) scintigram showed defects in the septum, inferior wall and apex. These findings suggest abnormality of the cardiac sympathetic nerve in neurofibromatosis.
authors.affiliation: Department of Cardiology, Nishikyoto Hospital, Kyoto.
authors.forename: T
authors.initials: T
authors.lastname: Fuchi
authors.forename: N
authors.initials: N
authors.lastname: Ishimoto
authors.forename: T
authors.initials: T
authors.lastname: Kajinami
authors.forename: M
authors.initials: M
authors.lastname: Kajinami
authors.forename: N
authors.initials: N
authors.lastname: Ohmichi
authors.forename: M
authors.initials: M
authors.lastname: Kinoshita
mesh_terms: D019797:3-Iodobenzylguanidine / Q000008:administration & dosage; D000328:Adult; D015906:Angioplasty, Balloon, Coronary; D000970:Antineoplastic Agents / Q000008:administration & dosage; D006328:Cardiac Catheterization; D003323:Coronary Aneurysm / Q000150:complications*; D003329:Coronary Vasospasm / Q000139:chemically induced / Q000150:complications*; D004874:Ergonovine / Q000008:administration & dosage; D006801:Humans; D007457:Iodine Radioisotopes / Q000008:administration & dosage; D008297:Male; D009203:Myocardial Infarction / Q000150:complications*; D017253:Neurofibromatoses / Q000150:complications* / Q000235:genetics; D010120:Oxytocics / Q000008:administration & dosage; D010375:Pedigree
chemical_list: D000970:Antineoplastic Agents; D007457:Iodine Radioisotopes; D010120:Oxytocics; D019797:3-Iodobenzylguanidine; D004874:Ergonovine