Psychomotor performance during initial stage of exposure to halothane, enflurane, isoflurane and sevoflurane in mice.
1. The dose-response relationship during the pre-anaesthetic and pre-equilibrium state of four inhalation anaesthetics (halothane, enflurane, isoflurane and sevoflurane) on fixed-ratio schedule-controlled behaviour was studied in mice. 2. Animals exposed to halothane, enflurane and isoflurane showed a biphasic pattern (i.e. a significant incremental increase in psychomotor responses at low inspired concentrations (0.1-0.4%) and decrements at greater concentrations) in a dose-dependent manner. Mean peak responses (per cent of control) were 132.3 (P < 0.01 vs control), 124.0 (P < 0.05) and 116.7% (P < 0.05) at 0.1% halothane, 0.3% enflurane and 0.2% isoflurane, respectively. 3. Sevoflurane did not increase schedule-controlled behavioural responses at any concentration. 4. The effect of subanaesthetic concentrations of inhalation anaesthetics on psychomotor performance can be evaluated as changes in the response rate in schedule-controlled behaviour.
Komatsu
H
H
Department of Anaesthesiology and Emergency Medicine, Kagawa Medical University, Japan. komatsu@kms.ac.jp
Nogaya
J
J
Kuratani
N
N
Ueki
M
M
Yokono
S
S
Ogli
K
K
D018685:Anesthetics, Inhalation / Q000494:pharmacology*; D000818:Animals; D003216:Conditioning, Operant / Q000187:drug effects; D004737:Enflurane / Q000494:pharmacology; D004987:Ethers / Q000494:pharmacology; D006221:Halothane / Q000494:pharmacology; D007530:Isoflurane / Q000494:pharmacology; D008297:Male; D008738:Methyl Ethers; D051379:Mice; D008815:Mice, Inbred Strains; D011597:Psychomotor Performance / Q000187:drug effects*; D012055:Reinforcement Schedule; D000077149:Sevoflurane
D018685:Anesthetics, Inhalation; D004987:Ethers; D008738:Methyl Ethers; D000077149:Sevoflurane; D004737:Enflurane; D007530:Isoflurane; D006221:Halothane