[Pharmacologic suppression of the ovarian function and its clinical usefulness].
The gonadotropin-releasing hormone (GnRH) is essential in human reproduction. By modification of the molecular structure of the original hormone, analogues were synthesized with agonistic or antagonistic effects. GnRH agonists have high binding affinity for receptors, and their prolonged or continuous use resulted in inhibition of LH and FSH release. On the other hand, GnRH antagonists have an entirely different mechanism of action but still suppress gonadotrophin release. Currently, the use of analogues of GnRH is an established therapy for hormone-dependent diseases and other clinical conditions.
Kershenovich Sefchovich
R
R
Clínica de Infertilidad-Endoscopia y Embarazo de Alto Riesgo, Hospital American British Cowdray (ABC).
Kably Ambe
A
A
García Morales
M A
MA
Peryra Quiñones
R
R
Barrón Vallejo
J
J
D005260:Female; D005640:Follicle Stimulating Hormone / Q000037:antagonists & inhibitors; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage* / Q000031:analogs & derivatives / Q000037:antagonists & inhibitors / Q000494:pharmacology; D006801:Humans; D007006:Hypogonadism / Q000188:drug therapy*; D007986:Luteinizing Hormone / Q000037:antagonists & inhibitors; D010053:Ovary / Q000187:drug effects*; D011966:Receptors, LHRH / Q000187:drug effects
D011966:Receptors, LHRH; D007987:Gonadotropin-Releasing Hormone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone