Genetic regulation of slowly progressing mild muscle atrophy in fast-twitch muscles of BUF/Mna rats.
BUF/Mna strain rats spontaneously develop slowly progressing mild-moderate muscle atrophy of extensor digitorum longus, tibialis, and extraocular muscles, which consist mainly of fast-twitch type fibers, at nearly 100% incidence. They have lighter extensor digitorum longus muscles than soleus muscles, when alive for more than 6 weeks. Genetic segregation of the development of the muscle atrophy was studied by crossing the BUF/ Mna strain with three other strains, ACI/NMs, WKY/NCrj, and BDIX, which were free of muscle atrophy. Two autosomal dominant susceptible genes, Mas-1 and Mas-2, determine the development of the muscle atrophy in these combinations of crosses.
Amo
H
H
Aichi Women's College, Japan.
Saito
M
M
Nagao
S
S
Yagiu
S
S
Takahashi
H
H
Morita
H
H
Morita
T M
TM
Matsuyama
M
M
D000818:Animals; D018450:Disease Progression; D005786:Gene Expression Regulation; D005799:Genes, Dominant; D020022:Genetic Predisposition to Disease; D006824:Hybridization, Genetic; D018656:Muscle Fibers, Fast-Twitch / Q000502:physiology*; D009133:Muscular Atrophy / Q000235:genetics* / Q000503:physiopathology*; D051381:Rats; D011915:Rats, Inbred BUF / Q000235:genetics* / Q000502:physiology*; D011919:Rats, Inbred Strains / Q000235:genetics