Familial liability to complications after BCG vaccination.
Adverse reactions induced by vaccination with bacille Calmette-Guerin (BCG) were observed in three infants from two blood-related families. A boy and a girl showed disseminated BCG infection with a fatal course in the former case. The third infant had regional suppurative lymphadenitis. Cases of two other children from the same families are also described: a boy who received BCG vaccine after 5 y of age without complications, and a girl who has not yet been vaccinated. The clinical course and immunological evaluation of the reported cases suggest a congenital immunodeficiency of an unusual transient nature. The role of genetic factors in familial susceptibility to mycobacterial infection also needs to be taken into consideration.
Banac
S
S
Department of Paediatrics, University Hospital, Rijeka, Croatia.
Franulović
J
J
D001500:BCG Vaccine / Q000009:adverse effects*; D002675:Child, Preschool; D017809:Fatal Outcome; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D007223:Infant; D008199:Lymphadenitis / Q000235:genetics / Q000276:immunology*; D008297:Male; D009164:Mycobacterium Infections / Q000235:genetics / Q000276:immunology*; D010375:Pedigree; D012189:Retrospective Studies; D016511:Severe Combined Immunodeficiency / Q000235:genetics
D001500:BCG Vaccine