title: Adaptive mutations produce resistance to ciprofloxacin.
abstract: Mutation to ciprofloxacin resistance continually occurred in nondividing Escherichia coli cells during a 7-day exposure to ciprofloxacin in agar, while no accumulation of rifampin resistance mutations was detected in those cells. We propose that the resistance mutations result from adaptive mutations, which preferentially produce phenotypes that promote growth in nondividing cells.
authors.affiliation: Department of Biology, University of Rochester, New York 14627, USA.
authors.forename: C
authors.initials: C
authors.lastname: Riesenfeld
authors.forename: M
authors.initials: M
authors.lastname: Everett
authors.forename: L J
authors.initials: LJ
authors.lastname: Piddock
authors.forename: B G
authors.initials: BG
authors.lastname: Hall
mesh_terms: D000222:Adaptation, Physiological; D000890:Anti-Infective Agents / Q000494:pharmacology*; D002939:Ciprofloxacin / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects* / Q000235:genetics* / Q000254:growth & development; D008826:Microbial Sensitivity Tests; D009154:Mutation
chemical_list: D000890:Anti-Infective Agents; D002939:Ciprofloxacin