title: Differential clinical courses of pregnancies complicated by diabetes insipidus which does, or does not, pre-date the pregnancy.
abstract: We present six cases of diabetes insipidus (DI) complicating pregnancy. In three cases, DI was manifested during pregnancy and required the administration of desmopressin acetate (1-desamino-8-D-arginine vasopressin, DDAVP). All these cases exhibited abnormal laboratory data such as an elevation of liver enzymes or a decrease in serum antithrombin III. The remaining three cases had suffered from DI before pregnancy which was well controlled on DDAVP. The clinical courses of these pregnancies were all uneventful subsequent to therapy. If DI is first recognized during pregnancy, attention should be paid to the possibility of abnormal liver function and eclampsia.
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Hamai
authors.forename: T
authors.initials: T
authors.lastname: Fujii
authors.forename: H
authors.initials: H
authors.lastname: Nishina
authors.forename: S
authors.initials: S
authors.lastname: Kozuma
authors.forename: H
authors.initials: H
authors.lastname: Yoshikawa
authors.forename: Y
authors.initials: Y
authors.lastname: Taketani
mesh_terms: D000328:Adult; D003894:Deamino Arginine Vasopressin / Q000627:therapeutic use; D003919:Diabetes Insipidus / Q000188:drug therapy / Q000201:enzymology / Q000503:physiopathology*; D016640:Diabetes, Gestational / Q000188:drug therapy / Q000201:enzymology / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D008099:Liver / Q000201:enzymology / Q000503:physiopathology*; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000188:drug therapy / Q000201:enzymology / Q000503:physiopathology*
chemical_list: D007004:Hypoglycemic Agents; D003894:Deamino Arginine Vasopressin