Immunogenetic and oncogenic properties of rat trophoblast cell lines.
OBJECTIVE
The nature of major histocompatibility complex (MHC) antigen expression on rat placentas, trophoblast cell lines, and tumors derived from trophoblast cells was explored.


METHODS
Cytohistochemical and flow cytometric analysis and molecular techniques.


RESULTS
MHC antigen expression and genomic imprinting on the placenta and on trophoblast cells varies with the time of gestation and with the type of MHC antigen.


CONCLUSIONS
There is no correlation in trophoblast cells between class I expression and cell ploidy, on the one hand, and malignant potential, on the other hand. Genomic imprinting of class I antigens in the rat placenta is a quantitative phenomenon.
Kunz
H W
HW
Department of Pathology, University of Pittsburgh School of Medicine, PA 15261, USA.
Yuan
X J
XJ
Salgar
S K
SK
Dixon-McCarthy
B
B
Gill
T J
TJ
D000818:Animals; D002460:Cell Line; D002471:Cell Transformation, Neoplastic / Q000276:immunology; D005260:Female; D005805:Genes, MHC Class I; D005802:Genes, MHC Class II; D018392:Genomic Imprinting; D015395:Histocompatibility Antigens Class I / Q000378:metabolism; D000949:Histocompatibility Antigens Class II / Q000378:metabolism; D011003:Ploidies; D011247:Pregnancy; D051381:Rats; D011920:Rats, Inbred WF; D014327:Trophoblasts / Q000166:cytology* / Q000276:immunology*
D015395:Histocompatibility Antigens Class I; D000949:Histocompatibility Antigens Class II