title: Amiodarone induced torsades de pointes with excessive QT dispersion following quinidine induced polymorphic ventricular tachycardia.
abstract: We report a case of amiodarone induced torsades de pointes (TdP) associated with increase QT dispersion in a patient with a history of quinidine induced TdP. An increase in QT dispersion of > 100% was noted on the 12 lead surface ECG postamiodarone therapy. In summary, amiodarone has a potential to induce TdP in patients with a previous history of quinidine induced TdP. QT dispersion could be a potential marker of TdP in these patients.
authors.affiliation: Division of Cardiovascular Therapeutics, Hartford Hospital, Connecticut 06102-5037, USA.
authors.forename: H T
authors.initials: HT
authors.lastname: Tran
authors.forename: M S
authors.initials: MS
authors.lastname: Chow
authors.forename: J
authors.initials: J
authors.lastname: Kluger
mesh_terms: D000328:Adult; D000638:Amiodarone / Q000009:adverse effects* / Q000627:therapeutic use; D000889:Anti-Arrhythmia Agents / Q000009:adverse effects* / Q000627:therapeutic use; D004562:Electrocardiography; D015716:Electrocardiography, Ambulatory; D005260:Female; D006801:Humans; D011802:Quinidine / Q000009:adverse effects* / Q000627:therapeutic use; D017180:Tachycardia, Ventricular / Q000139:chemically induced* / Q000175:diagnosis; D016171:Torsades de Pointes / Q000139:chemically induced* / Q000175:diagnosis
chemical_list: D000889:Anti-Arrhythmia Agents; D011802:Quinidine; D000638:Amiodarone