[Telomerase inhibitor].
Human normal somatic cells and tissues have undetectable or very weak telomerase activity and shorten telomere size at each cell division resulting in a limited proliferative life span. Human germ tissues and most tumor tissues have telomerase activity and maintain telomere size during cell proliferation resulting in unlimited growth. Telomerase is expected to be a new target for cancer chemotherapy. Cultured tumor cells are shown to die after losing telomerase activity.
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Dept. of Cellular and Molecular Biology, Hiroshima University School of Medicine.
D004791:Enzyme Inhibitors / Q000494:pharmacology*; D006801:Humans; D009369:Neoplasms / Q000201:enzymology / Q000473:pathology; D019098:Telomerase / Q000037:antagonists & inhibitors*
D004791:Enzyme Inhibitors; D019098:Telomerase