Genetics of multiple sclerosis.
Multiple Sclerosis (MS) is a common chronic central nervous system disease in young adults. Relative familial risk appears to be determined largely by genes while population risk is strongly influenced by environmental factors. This is supported by genetic epidemiological studies which also suggest an oligogenic inheritance of susceptibility. The HLA DRB1*1501, DQA1*0102, DQB1 0602 haplotype is associated with the disease but HLA contributes only modestly to overall susceptibility. The results of three genomic searches are concordant with the genetic epidemiology and imply a number of genes with interacting effects will be found. Importantly, no single region has been identified with a major influence on familial risk.
Dyment
D A
DA
Department of Biochemistry, University of Western Ontario, London, Canada.
Sadovnick
A D
AD
Ebers
G C
GC
Sadnovich
A D
AD
D000328:Adult; D002874:Chromosome Mapping; D002877:Chromosomes, Human; D004198:Disease Susceptibility; D004200:Diseases in Twins / Q000235:genetics; D004777:Environment; D005190:Family; D005819:Genetic Markers; D006681:HLA-D Antigens / Q000235:genetics*; D006683:HLA-DQ Antigens / Q000235:genetics; D059848:HLA-DQ alpha-Chains; D059866:HLA-DQ beta-Chains; D006684:HLA-DR Antigens / Q000235:genetics; D059811:HLA-DRB1 Chains; D006801:Humans; D009103:Multiple Sclerosis / Q000453:epidemiology / Q000235:genetics*; D012307:Risk Factors
D005819:Genetic Markers; D006681:HLA-D Antigens; D006683:HLA-DQ Antigens; D059848:HLA-DQ alpha-Chains; D059866:HLA-DQ beta-Chains; C069050:HLA-DQA1 antigen; C069051:HLA-DQB1 antigen; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains