Prevention of splenic granuloma formation in adjuvant arthritis by 2-acetyl-4-tetrahydroxybutylimidazole (THI).
Adjuvant-induced arthritis (AA) in Lewis rats is a widely used model of chronic inflammatory arthritis. Non-articular features such as weight loss and necrotizing granulomas of the spleen and lymph nodes also occur in this model. The compound 2-acetyl-4-tetrahydroxybutylimidazole (THI) marginally delayed the development of AA. However, this agent had no effect on the incidence or severity of disease. In contrast, THI totally prevented granuloma formation in the spleen and associated splenomegaly. We conclude that THI may be a useful adjunctive agent for some inflammatory diseases.
Gugasyan
R
R
Reid Rheumatology Laboratory, Burnet Clinical Research Unit, Walter and Eliza Hall Institute of Medical Research, Victoria, Australia.
Clouston
D
D
Mandel
T
T
Wicks
I
I
D000818:Animals; D001169:Arthritis, Experimental / Q000150:complications* / Q000188:drug therapy* / Q000276:immunology; D006099:Granuloma / Q000209:etiology* / Q000517:prevention & control; D007093:Imidazoles / Q000627:therapeutic use*; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D051381:Rats; D011917:Rats, Inbred Lew; D013154:Spleen / Q000473:pathology; D013158:Splenic Diseases / Q000209:etiology* / Q000517:prevention & control; D013163:Splenomegaly / Q000209:etiology / Q000517:prevention & control
D007093:Imidazoles; D007166:Immunosuppressive Agents; C049929:2-acetyl-4(5)-tetrahydroxybutylimidazole