Central interleukin-1 receptors as mediators of sickness.
These data establish that cytokines, such as IL-1, can act on specific receptors within the brain to induce many symptoms of sickness. A number of inflammatory stimuli in the periphery can activate both the transcription and translation of IL-1 within the central nervous system. It will now be important to determine if similar central IL-1 pathways are activated during SLE and whether these central inflammatory cytokines are involved in the neurologic complications that often accompany this disease.
Kelley
K W
KW
Laboratory of Immunophysiology, University of Illinois, Urbana 61801, USA. kwkelley@uiuc.edu
Hutchison
K
K
French
R
R
Bluthé
R M
RM
Parnet
P
P
Johnson
R W
RW
Dantzer
R
R
D000818:Animals; D001921:Brain / Q000378:metabolism* / Q000502:physiology; D002493:Central Nervous System Diseases / Q000209:etiology*; D016207:Cytokines / Q000502:physiology; D006801:Humans; D007107:Immune System / Q000502:physiology; D008180:Lupus Erythematosus, Systemic / Q000150:complications*; D017472:Receptors, Interleukin-1 / Q000502:physiology*; D015398:Signal Transduction
D016207:Cytokines; D017472:Receptors, Interleukin-1