title: Evidence of apoptotic procedure in deafferented striatum after cortical injury in young adult rats.
abstract: In denervated striatum after excitotoxic cortical lesion in young adult rats, apoptotic cells, though quite few, were observed by TUNEL 2 weeks after surgery. Also, prominent expressions of p53 were observed at the same time. These data indicate that apoptotic procedure may be involved in the denervation-induced degeneration even in young adults.
authors.affiliation: Department of Neurosurgery, Oita Medical University, Japan. isonom@oita-med.ac.jp
authors.forename: M
authors.initials: M
authors.lastname: Isono
authors.forename: Y
authors.initials: Y
authors.lastname: Wakabayashi
authors.forename: M
authors.initials: M
authors.lastname: Fujiki
authors.forename: R
authors.initials: R
authors.lastname: Inoue
authors.forename: K
authors.initials: K
authors.lastname: Asakuno
authors.forename: S
authors.initials: S
authors.lastname: Hori
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000276:immunology*; D001930:Brain Injuries / Q000503:physiopathology*; D003342:Corpus Striatum / Q000473:pathology*; D004195:Disease Models, Animal; D007150:Immunohistochemistry; D009410:Nerve Degeneration / Q000276:immunology; D051381:Rats; D017208:Rats, Wistar; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism
chemical_list: D016159:Tumor Suppressor Protein p53