title: Penicillin-binding proteins and induction of AmpC beta-lactamase.
abstract: In competition assays for radiolabeled penicillin, penicillin-binding proteins (PBPs) 4, 7a, and 7b showed very high affinities for strong inducers of AmpC beta-lactamase. Loss of PBP 4 resulted in diminished inducibility. This suggests that if PBPs are involved in induction of AmpC beta-lactamase, there is probably a redundancy in function among the different PBPs.
authors.affiliation: Center for Research in Anti-Infectives and Biotechnology, Department of Medical Microbiology, Creighton University School of Medicine, Omaha, Nebraska 68178, USA.
authors.forename: C C
authors.initials: CC
authors.lastname: Sanders
authors.forename: P A
authors.initials: PA
authors.lastname: Bradford
authors.forename: A F
authors.initials: AF
authors.lastname: Ehrhardt
authors.forename: K
authors.initials: K
authors.lastname: Bush
authors.forename: K D
authors.initials: KD
authors.lastname: Young
authors.forename: T A
authors.initials: TA
authors.lastname: Henderson
authors.forename: W E
authors.initials: WE
authors.lastname: Sanders
mesh_terms: D001426:Bacterial Proteins; D002352:Carrier Proteins / Q000378:metabolism*; D004790:Enzyme Induction; D004926:Escherichia coli / Q000201:enzymology* / Q000378:metabolism*; D006602:Hexosyltransferases; D002267:Muramoylpentapeptide Carboxypeptidase / Q000378:metabolism*; D046915:Penicillin-Binding Proteins; D010458:Peptidyl Transferases; D001618:beta-Lactamases / Q000096:biosynthesis*
chemical_list: D001426:Bacterial Proteins; D002352:Carrier Proteins; D046915:Penicillin-Binding Proteins; D010458:Peptidyl Transferases; D006602:Hexosyltransferases; D002267:Muramoylpentapeptide Carboxypeptidase; C048795:AmpC beta-lactamases; D001618:beta-Lactamases