title: Rutoxyl [rutin/4-acetamide-1-hydroxy-2,2,6,6-tetramethylpiperidinium] is a new member of the class of semi-natural products of high pharmacological potency.
abstract: A novel complex, Rutoxyl [rutin/4-acetamide-1-hydroxy-2,2,6,6-tetramethylpiperidinium] was synthesized and its structure and anticancer activity were investigated. The results reported here are consistent with our idea, that the formation of such a complex of two biologically active molecules: polyphenolic flavonoid antioxidant (Rutin) and nitroxylamine of nitroxide antioxidant (Tempace), stabilized by hydrogen bond(s) can result in a supra-additive properties.
authors.affiliation: Institute of Applied Radiation Chemistry, Technical University of Lódź, Poland. media@mitr.p.lodz.pl
authors.forename: D
authors.initials: D
authors.lastname: Metodiewa
authors.forename: J
authors.initials: J
authors.lastname: Skolimowski
authors.forename: A
authors.initials: A
authors.lastname: Kochman
authors.forename: S
authors.initials: S
authors.lastname: Karolczak
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology; D003497:Cyclic N-Oxides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D015195:Drug Design; D004354:Drug Screening Assays, Antitumor; D008297:Male; D008958:Models, Molecular; D015394:Molecular Structure; D010880:Piperidines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012431:Rutin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D012513:Sarcoma, Experimental / Q000188:drug therapy; D013329:Structure-Activity Relationship
chemical_list: C108638:4-acetamido-1-hydroxy-2,2,6,6-tetramethylpiperidinium; D000970:Antineoplastic Agents; D000975:Antioxidants; D003497:Cyclic N-Oxides; D010880:Piperidines; C104520:tempace; D012431:Rutin