Glial cell extracellular matrix: boundaries for axon growth in development and regeneration.
Astrocytes and other glia in the central nervous system are now thought to produce molecules that negatively modulate axon growth, thereby influencing axon pathfinding in both development and regeneration. The relevant evidence for glial cell boundaries and the inhibitory molecules present in these extracellular matrix structures is discussed in this minireview.
Fitch
M T
MT
Department of Neurosciences, Case Western Reserve University School of Medicine, 10900 Euclid Avenue, Cleveland, Ohio 44106, USA. mtf@po.cwru.edu
Silver
J
J
D000818:Animals; D001369:Axons / Q000502:physiology*; D005109:Extracellular Matrix / Q000502:physiology*; D006801:Humans; D009416:Nerve Regeneration; D009420:Nervous System / Q000196:embryology*; D009424:Nervous System Physiological Phenomena; D009457:Neuroglia / Q000502:physiology*; D009474:Neurons / Q000502:physiology