title: Mode of chemotherapy does not affect complications with an implantable venous access device.
abstract: BACKGROUND
  Few reports have been made regarding the long term safety of implantable venous access devices used for the delivery of chemotherapeutic agents. The authors' goals were to determine the frequency of complications in patients receiving chemotherapy with these devices; to determine whether complications were associated with the mode of chemotherapy delivery (push/bolus or infusional regimens); and to evaluate the influence of other risk factors, including home-based versus hospital-based administration.
  
  
  METHODS
  A total of 152 oncology patients at the John L. McClellan Memorial Veterans Administration Medical Center in Little Rock, Arkansas (ages 26-81 years; mean age, 62 years), who underwent surgical placement of an Infus-a-Port (Strato, Inc., Beverly, MA) between May 1, 1992 and May 31, 1994, were evaluated retrospectively for postplacement device complications, such as infection, thrombosis, and mechanical failure.
  
  
  RESULTS
  Twenty-seven patients experienced 1 complication each: 17 episodes of device-related sepsis, cellulitis, or fever of unknown origin; 8 episodes of thrombosis or catheter occlusion; 1 episode of drug extravasation; and 1 mechanical failure. Patient age, frequency of port accession, mode of chemotherapy delivery, tumor type, and neutropenia were evaluated as risk factors, but none was statistically significant. Complications were more frequent during the first 90 days after implantation, but they continued to occur throughout the observation period.
  
  
  CONCLUSIONS
  Complications attributable to an implantable venous access device were infrequent in this patient population. No differences in complications for patients receiving home-based versus hospital-based chemotherapy administration were noted, opening the possibility of significant time and cost savings with home treatment.
authors.affiliation: Department of Pharmacy, John L. McClellan Memorial Veterans Administration Medical Center, Little Rock, Arkansas 72205, USA.
authors.forename: D F
authors.initials: DF
authors.lastname: Brown
authors.forename: M J
authors.initials: MJ
authors.lastname: Muirhead
authors.forename: P M
authors.initials: PM
authors.lastname: Travis
authors.forename: S R
authors.initials: SR
authors.lastname: Vire
authors.forename: J
authors.initials: J
authors.lastname: Weller
authors.forename: M
authors.initials: M
authors.lastname: Hauer-Jensen
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D002405:Catheterization, Central Venous / Q000009:adverse effects* / Q000295:instrumentation; D002481:Cellulitis / Q000209:etiology; D004866:Equipment Contamination; D004868:Equipment Failure; D005119:Extravasation of Diagnostic and Therapeutic Materials / Q000209:etiology; D005260:Female; D005335:Fever of Unknown Origin / Q000209:etiology; D018718:Home Infusion Therapy / Q000009:adverse effects; D006801:Humans; D015918:Infusion Pumps, Implantable / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D009503:Neutropenia / Q000209:etiology; D016522:Oncology Service, Hospital; D012189:Retrospective Studies; D018805:Sepsis / Q000209:etiology / Q000382:microbiology; D013223:Statistics as Topic; D016019:Survival Analysis; D013924:Thrombophlebitis / Q000209:etiology
chemical_list: D000970:Antineoplastic Agents