Increased granulocyte aggregation in vitro in diabetes mellitus.
Having previously shown an increase in white blood cell (WBC) aggregation in groups known to have a high incidence of cardiovascular events, we compared 28 patients with diabetes mellitus and no history or clinical evidence of macrovascular disease with 28 age- and sex-matched normal controls. Patients and controls had blood taken in the morning and analysed for WBC aggregation in vitro using a whole blood technique. WBC aggregation was significantly higher in the diabetic group compared with the normal controls (mean +/- SD 31.10 +/- 10.26% vs. 25.7 +/- 9.38%; p < 0.04, Student t-test). WBC aggregation predates the appearance of clinical symptoms of macrovascular disease in diabetes.
Elhadd
T A
TA
University Department of Medicine, Ninewells Hospital and Medical School, Dundee, UK.
Bancroft
A
A
McLaren
M
M
Newton
R W
RW
Belch
J J
JJ
D000368:Aged; D002449:Cell Aggregation; D018929:Cell Culture Techniques; D003920:Diabetes Mellitus / Q000097:blood*; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006098:Granulocytes / Q000502:physiology*; D006801:Humans; D008214:Lymphocytes / Q000502:physiology; D008297:Male; D008875:Middle Aged
D006442:Glycated Hemoglobin