Splanchnic vascular control during sepsis and endotoxemia.
Endotoxemia and sepsis often result in circulatory derangements which manifest as perfusion maldistributions. It has been widely accepted that the splanchnic circulation decreases in perfusion during advanced septic or endotoxemic states. Impaired perfusion of splanchnic organs may result not only in organ dysfunction but also exacerbations of polymicrobial bacteremia due to intestinal mucosal leakage. Consequently, evaluation of the splanchnic mechanisms of vasoregulation and how perfusion is maintained is vital to any topic concerning the management of the septic patient.
Sam
A D
AD
Department of Surgery, The University of Illinois College of Medicine at Chicago, 835 South Wolcott Avenue, Chicago, IL 60612-7342, USA. adsam@ uic.edu
Sharma
A C
AC
Law
W R
WR
Ferguson
J L
JL
D000818:Animals; D016207:Cytokines / Q000502:physiology; D004195:Disease Models, Animal; D019446:Endotoxemia / Q000503:physiopathology*; D006801:Humans; D008099:Liver / Q000098:blood supply; D010477:Perfusion; D012039:Regional Blood Flow; D018805:Sepsis / Q000503:physiopathology* / Q000628:therapy; D013152:Splanchnic Circulation / Q000502:physiology*
D016207:Cytokines