Synovial fluid levels of tumor necrosis factor-alpha in the inflamed rat knee: modulation by dexamethasone and inhibitors of matrix metalloproteinase and phosphodiesterase.
Singh
H N
HN
Research Department, Ciba-Geigy Corporation, Summit, NJ 07901, USA. Hem.Singh@pharma.novartis.com
Blancuzzi
V
V
Greenwood
S
S
Skiles
J W
JW
O'Byrne
E M
EM
D000818:Animals; D001172:Arthritis, Rheumatoid / Q000378:metabolism*; D003907:Dexamethasone / Q000494:pharmacology*; D005260:Female; D007700:Kinetics; D008070:Lipopolysaccharides / Q000494:pharmacology; D008666:Metalloendopeptidases / Q000037:antagonists & inhibitors*; D010726:Phosphodiesterase Inhibitors / Q000494:pharmacology*; D011760:Pyrrolidinones / Q000494:pharmacology; D051381:Rats; D011917:Rats, Inbred Lew; D020889:Rolipram; D013582:Synovial Fluid / Q000378:metabolism*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
D008070:Lipopolysaccharides; D010726:Phosphodiesterase Inhibitors; D011760:Pyrrolidinones; D014409:Tumor Necrosis Factor-alpha; D003907:Dexamethasone; D008666:Metalloendopeptidases; D020889:Rolipram