title: Effects of cigarette smoking on the serum concentration of lung surfactant protein A (SP-A).
abstract: We have tested the hypothesis that serum surfactant protein A (SP-A) production may be affected by cigarette smoke exposure, and that alterations in serum levels may reflect smoking habits. A total of 52 subjects were divided into the following two groups: active smokers (Group A; n = 23); and nonsmokers (Group B; n = 29). The assessment of smoking habit was determined by self-report, carbon monoxide concentration in expired air, and cotinine concentration in urine. Serum SP-A was compared in both groups and was found to be higher in Group A (active smokers) (p < 0.002). We conclude that surfactant protein A levels are increased in the serum of smokers. However, it was found that this is not a sensitive discriminating factor to separate smokers from nonsmokers.
authors.affiliation: Pulmonary Division, Tokyo Metropolitan Geriatric Hospital, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Kida
authors.forename: H
authors.initials: H
authors.lastname: Oda
authors.forename: Y
authors.initials: Y
authors.lastname: Yamano
authors.forename: J
authors.initials: J
authors.lastname: Kagawa
mesh_terms: D000328:Adult; D003367:Cotinine / Q000652:urine; D005541:Forced Expiratory Volume; D006801:Humans; D008297:Male; D008875:Middle Aged; D011510:Proteolipids / Q000097:blood*; D037662:Pulmonary Surfactant-Associated Protein A; D037661:Pulmonary Surfactant-Associated Proteins; D011663:Pulmonary Surfactants / Q000097:blood*; D012907:Smoking / Q000097:blood* / Q000503:physiopathology / Q000652:urine; D014797:Vital Capacity
chemical_list: D011510:Proteolipids; D037662:Pulmonary Surfactant-Associated Protein A; D037661:Pulmonary Surfactant-Associated Proteins; D011663:Pulmonary Surfactants; D003367:Cotinine