title: Effect of stanozolol on body composition, nitrogen balance, and food consumption in castrated dogs with chronic renal failure.
abstract: OBJECTIVE
  To determine the effect of stanozolol on body composition, nitrogen balance, and food consumption in castrated dogs with chronic renal failure.
  
  
  METHODS
  Blinded crossover trial.
  
  
  METHODS
  22 castrated Beagles with experimentally induced chronic renal failure.
  
  
  METHODS
  Dogs were divided into 2 groups of 11 dogs each. During each of two 6-week treatment periods, dogs in 1 group received stanozolol, and those in the other group received a control agent. Nitrogen balance, body composition, and food consumption were determined.
  
  
  RESULTS
  During administration of stanozolol, the amount of food consumed per dog, lean body mass, and nitrogen balance increased. Stanozolol did not have a significant effect on body fat, bone mineral content, or food consumption per kilogram of body weight.
  
  
  CONCLUSIONS
  For dogs with mild-to-moderate, nonuremic, experimentally induced, chronic renal failure, stanozolol had positive effects on nitrogen balance and lean body mass.
authors.affiliation: Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan 66506, USA.
authors.forename: L A
authors.initials: LA
authors.lastname: Cowan
authors.forename: R
authors.initials: R
authors.lastname: McLaughlin
authors.forename: P W
authors.initials: PW
authors.lastname: Toll
authors.forename: S A
authors.initials: SA
authors.lastname: Brown
authors.forename: T I
authors.initials: TI
authors.lastname: Moore
authors.forename: M D
authors.initials: MD
authors.lastname: Butine
authors.forename: G
authors.initials: G
authors.lastname: Milliken
mesh_terms: D045930:Anabolic Agents / Q000494:pharmacology*; D000818:Animals; D001823:Body Composition / Q000187:drug effects* / Q000502:physiology; D002245:Carbon Dioxide / Q000097:blood; D002712:Chlorides / Q000097:blood; D003404:Creatinine / Q000097:blood; D018592:Cross-Over Studies; D004283:Dog Diseases / Q000378:metabolism / Q000503:physiopathology*; D004285:Dogs; D004435:Eating / Q000187:drug effects* / Q000502:physiology; D007676:Kidney Failure, Chronic / Q000378:metabolism / Q000503:physiopathology / Q000662:veterinary*; D008297:Male; D009584:Nitrogen / Q000097:blood / Q000378:metabolism*; D009919:Orchiectomy / Q000662:veterinary; D016037:Single-Blind Method; D013197:Stanozolol / Q000494:pharmacology*
chemical_list: D045930:Anabolic Agents; D002712:Chlorides; D002245:Carbon Dioxide; D013197:Stanozolol; D003404:Creatinine; D009584:Nitrogen