Fused pyrrolo[2,3-c]carbazol-6-ones: novel immunostimulants that enhance human interferon-gamma activity.
Hudkins
R L
RL
Department of Medicinal Chemistry, Cephalon, Inc., West Chester, Pennsylvania 19380, USA.
Diebold
J L
JL
Angeles
T S
TS
Knight
E
E
D000276:Adjuvants, Immunologic / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002227:Carbazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D019281:Dimerization; D004357:Drug Synergism; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology; D006684:HLA-DR Antigens / Q000096:biosynthesis*; D006801:Humans; D007202:Indicators and Reagents; D007371:Interferon-gamma / Q000494:pharmacology*; D015394:Molecular Structure; D011493:Protein Kinase C / Q000037:antagonists & inhibitors; D011758:Pyrroles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D019311:Staurosporine / Q000494:pharmacology; D013329:Structure-Activity Relationship
D000276:Adjuvants, Immunologic; D002227:Carbazoles; D004791:Enzyme Inhibitors; D006684:HLA-DR Antigens; D007202:Indicators and Reagents; D011758:Pyrroles; D007371:Interferon-gamma; D011493:Protein Kinase C; D019311:Staurosporine