Human papillomavirus and schistosomiasis associated bladder cancer.
OBJECTIVE
To determine the human papillomavirus DNA status of schistosomal associated squamous cell carcinoma of the urinary bladder in South Africa.


METHODS
Twenty five archival samples of bladder squamous cell carcinoma associated with Schistosoma haematobium were subjected to non-isotopic in situ hybridisation and the polymerase chain reaction for the detection of human papillomavirus 6, 11, 16, 18, 31, and 33 genotypes.


RESULTS
Using these two techniques, none of the 25 cases was shown to harbour human papillomavirus DNA.


CONCLUSIONS
This study abrogates the role of human papillomavirus in schistosoma associated bladder carcinoma in South Africa. It is suggested that other factors including nitrosamine exposure, p53 mutation, and additional unknown chromosomal events play a major role in the development of this parasite associated neoplasm.
Cooper
K
K
Department of Anatomical Pathology, School of Pathology, South African Institute for Medical Research, Johannesburg, South Africa.
Haffajee
Z
Z
Taylor
L
L
D002294:Carcinoma, Squamous Cell / Q000469:parasitology / Q000821:virology*; D004279:DNA, Viral / Q000032:analysis; D006801:Humans; D017403:In Situ Hybridization; D027383:Papillomaviridae / Q000235:genetics*; D030361:Papillomavirus Infections / Q000150:complications*; D016133:Polymerase Chain Reaction; D012553:Schistosomiasis haematobia / Q000150:complications*; D014412:Tumor Virus Infections / Q000150:complications*; D001749:Urinary Bladder Neoplasms / Q000469:parasitology / Q000821:virology*
D004279:DNA, Viral