Preparation and properties of a stable intravenous lorazepam emulsion.
Lorazepam is normally administered as a solution in organic solvents such as propylene glycol. This type of formulation is undesirable. This study describes the development of a parenteral emulsion formulation for lorazepam. The stability of lorazepam in the emulsion was examined. Ten per cent corn oil emulsions stabilized with egg lecithin, Pluronic F68 and Pluronic F88 were used. The incorporation of lorazepam does not appear to destabilize the emulsion, and lorazepam itself appears to be stable for at least 1 year in this liquid formulation. Haemolysis caused by emulsion formulations containing lorazepam and different emulsifiers was evaluated using human and rabbit blood to assess their safety as parenteral drug carriers. The results show that the emulsions did not have any significant haemolytic activity whereas organic solvents and solutions of lorazepam in organic solvents caused substantial haemolysis.
Yalin
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Refik Saydam Central Institute of Hygiene, Drug, Cosmetic and Research Department, Ankara, Turkey.
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D000818:Animals; D014151:Anti-Anxiety Agents / Q000008:administration & dosage* / Q000097:blood; D004355:Drug Stability; D004655:Emulsions / Q000737:chemistry; D005079:Excipients; D006461:Hemolysis; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007275:Injections, Intravenous; D008140:Lorazepam / Q000008:administration & dosage* / Q000097:blood; D010713:Phosphatidylcholines; D011060:Poloxalene; D011817:Rabbits
D014151:Anti-Anxiety Agents; D004655:Emulsions; D005079:Excipients; D010713:Phosphatidylcholines; D011060:Poloxalene; D008140:Lorazepam