[Tubular necrosis after non-steroidal anti-inflammatory agents and acute alcoholic intoxication].
Acute nephrotoxicity due to nonsteroidal anti-inflammatory drugs is usually observed in clinical situations in which renal perfusion is compromised as in volume contraction. We report a case of a 20 year-old woman who suffered from acute tubular necrosis after concomitant ingestion of nonsteroidal anti-inflammatory drugs and binge drinking. This acute tubular necrosis is likely to have an hemodynamic origin due to nonsteroidal anti-inflammatory drugs in a patient with volume contraction secondary to binge drinking. The risk appears to be even more important since ethanol has been implicated in tubular necrosis by direct toxicity. This observation underlines the danger in associating nonsteroidal anti-inflammatory drugs and ethanol.
Galzin
M
M
Service de néphrologie et hémodialyse, Hôpital Sainte Marguerite, Marseille.
Brunet
P
P
Burtey
S
S
Dussol
B
B
Berland
Y
Y
D058186:Acute Kidney Injury / Q000139:chemically induced / Q000150:complications / Q000503:physiopathology; D000328:Adult; D000435:Alcoholic Intoxication / Q000150:complications*; D001810:Blood Volume / Q000187:drug effects; D016861:Cyclooxygenase Inhibitors / Q000009:adverse effects*; D004357:Drug Synergism; D000431:Ethanol / Q000494:pharmacology / Q000506:poisoning*; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007660:Ketoprofen / Q000009:adverse effects*; D007683:Kidney Tubular Necrosis, Acute / Q000097:blood / Q000139:chemically induced* / Q000503:physiopathology; D012084:Renin-Angiotensin System / Q000187:drug effects
D016861:Cyclooxygenase Inhibitors; D000431:Ethanol; D007660:Ketoprofen