title: Rat MDC family of proteins: sequence analysis, tissue distribution, and expression in prepubertal and adult rat testis.
abstract: Increasing number of sequence-related cysteine-rich membrane proteins containing metalloproteinase-like and disintegrin-like domains (the MDC protein family) have been identified in mammalian tissues. Here, we report the cloning and sequence analysis of cDNAs encoding several rat orthologues of this protein family, some of which are found to be expressed exclusively in the male reproductive tract, others exhibiting a broader tissue distribution. We also examine their expression in prepubertal an adult rat testis, which, in conjunction with the data on tissue distribution, form a necessary prelude to further studies aimed at establishing their individual functions.
authors.affiliation: Department of Biochemistry, University of Bristol, School of Medical Sciences, UK.
authors.forename: J
authors.initials: J
authors.lastname: Frayne
authors.forename: J A
authors.initials: JA
authors.lastname: Jury
authors.forename: H L
authors.initials: HL
authors.lastname: Barker
authors.forename: L
authors.initials: L
authors.lastname: Hall
mesh_terms: D051722:ADAM Proteins; D000595:Amino Acid Sequence; D000818:Animals; D003001:Cloning, Molecular; D000072196:Fertilins; D006801:Humans; D008297:Male; D008562:Membrane Glycoproteins / Q000235:genetics / Q000378:metabolism; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism*; D008666:Metalloendopeptidases / Q000235:genetics / Q000378:metabolism; D008969:Molecular Sequence Data; D011506:Proteins / Q000235:genetics / Q000378:metabolism; D051381:Rats; D017422:Sequence Analysis, DNA; D012741:Sexual Maturation / Q000502:physiology*; D013737:Testis / Q000254:growth & development / Q000378:metabolism*
chemical_list: D008562:Membrane Glycoproteins; D008565:Membrane Proteins; D011506:Proteins; C088719:tMDC I protein, Macaca fascicularis; C096913:tMDC IV protein, Macaca fascicularis; D051722:ADAM Proteins; C098660:ADAM15 protein, human; C490902:Adam15 protein, mouse; C490901:Adam15 protein, rat; C108914:Adam18 protein, rat; C093559:Adam4 protein, mouse; C093560:Adam5 protein, mouse; C484218:Adam5 protein, rat; C093561:Adam6a protein, rat; C076862:Adam7 protein, rat; D000072196:Fertilins; D008666:Metalloendopeptidases