title: Intranasal fluticasone propionate for chronic eosinophilic rhinitis in patients with aspirin-induced asthma.
abstract: We performed a double-blind, crossover, placebo-controlled study on the effect of fluticasone propionate (FP) treatment on chronic eosinophilic rhinosinusitis in 15 patients with aspirin-induced asthma (AIA). There were 10 women and five men aged 32-60 years; average: 45 years. After a 10-day run-in period, patients underwent two 4-week treatment courses (FP vs placebo), separated by a 2-week washout interval. Clinical activity of FP was evaluated by daily measurement of peak nasal inspiratory flow (PNIF) and a scoring system of subjective symptoms. Nasal challenges with E-lysine aspirin, using active anterior rhinomanometry, were performed at the entry and on the last day of each treatment period. Weekly mean values of symptom scores were generally lower and PNIF measurements higher during treatment with FP than with placebo. This difference was statistically significant for most recorded parameters for the whole 4-week FP treatment. On average, the reactions evoked by aspirin nasal challenge were significantly shorter and milder after treatment with FP than with placebo. In 8/13 patients, FP completely prevented aspirin-precipitated nasal reaction, whereas protection after placebo was observed in only 2/12 subjects (P = 0.004). We conclude that intranasal FP is an effective therapy for chronic eosinophilic rhinitis in patients with AIA.
authors.affiliation: Jagiellonian University School of Medicine, Department of Medicine, Cracow, Poland.
authors.forename: L
authors.initials: L
authors.lastname: Mastalerz
authors.forename: M
authors.initials: M
authors.lastname: Milewski
authors.forename: M
authors.initials: M
authors.lastname: Duplaga
authors.forename: E
authors.initials: E
authors.lastname: Nizankowska
authors.forename: A
authors.initials: A
authors.lastname: Szczeklik
mesh_terms: D000281:Administration, Intranasal; D000328:Adult; D000730:Androstadienes / Q000627:therapeutic use*; D018926:Anti-Allergic Agents / Q000627:therapeutic use*; D001241:Aspirin / Q000009:adverse effects*; D001249:Asthma / Q000139:chemically induced*; D002908:Chronic Disease; D018592:Cross-Over Studies; D004311:Double-Blind Method; D004802:Eosinophilia / Q000139:chemically induced* / Q000188:drug therapy*; D005260:Female; D000068298:Fluticasone; D006801:Humans; D008297:Male; D008875:Middle Aged; D009299:Nasal Provocation Tests; D012220:Rhinitis / Q000139:chemically induced* / Q000188:drug therapy*
chemical_list: D000730:Androstadienes; D018926:Anti-Allergic Agents; D000068298:Fluticasone; D001241:Aspirin