title: Are omphalocele and neural tube defects related congenital anomalies?: Data from 21 registries in Europe (EUROCAT).
abstract: We have analyzed the association between omphalocele and neural tube defects (O/NTD) previously reported in epidemiological studies of EUROCAT registry data [Dolk et al., 1991; Calzolari et al., 1995]. By examining differences in prevalence between the United Kingdom and Ireland (UKI) and Continental Europe and Malta (CEM) and differences in sex ratio, the possible etiopathogenetic differences between O/NTD association and omphalocele without NTD and NTD without omphalocele were investigated. The distribution of O/NTD cases according to NTD site in the two geographic areas shows in the UKI a tendency for omphalocele to associate with anencephaly/spina bifida and with anencephaly. In CEM centers, these types of NTD are much rarer. The pattern of other anomalies occurring in combination with O/NTD association in the same babies was also analysed.
authors.affiliation: Istituto di Genetica Medica, Universita' di Ferrara, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Calzolari
authors.forename: F
authors.initials: F
authors.lastname: Bianchi
authors.forename: H
authors.initials: H
authors.lastname: Dolk
authors.forename: D
authors.initials: D
authors.lastname: Stone
authors.forename: M
authors.initials: M
authors.lastname: Milan
mesh_terms: D001723:Birth Rate; D000013:Congenital Abnormalities / Q000453:epidemiology* / Q000209:etiology; D005060:Europe / Q000453:epidemiology; D005260:Female; D006554:Hernia, Umbilical / Q000453:epidemiology*; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D009436:Neural Tube Defects / Q000453:epidemiology*; D012042:Registries / Q000706:statistics & numerical data