[Interferon].
Interferon (IFN) has anti-cell-proliferative activities. Some of the interferon-stimulated gene (ISGs) products have important roles for controlling cell proliferation and cell differentiation. Candidates for that kind of ISGs involve PKR, IRF-1, IRF-2, 2'5' OAS, RNaseL, and ICSBP. The PKR phosphorylate eIF2 alpha that leads to blocking of protein synthesis, mediates signal transduction via NF-kappa B and/or probably IRF-1, and is also involved in apoptosis. IRF-1 leads to apoptosis to prevent malignant transformation when a cell undergoes initial oncogene activation, and controls cell proliferation by balancing with IRF-2. 2'5' OAS and RNaseL system also has possibilities to have those roles. ICSBP, one of the IRF family, has new findings from the knock-out mouse. The mouse developed a hematopoietic abnormality which looks very similar to human chronic myelogenous leukemia, indicating ICSBP has important roles in proliferation and differentiation of hematopoietic stem cells.
Tanaka
H
H
Dept. of Hematology and Oncology, Hiroshima University.
D000818:Animals; D000970:Antineoplastic Agents; D017209:Apoptosis; D002352:Carrier Proteins / Q000737:chemistry; D004268:DNA-Binding Proteins / Q000737:chemistry; D006801:Humans; D050856:Interferon Regulatory Factor-1; D050836:Interferon Regulatory Factor-2; D050835:Interferon Regulatory Factors; D007372:Interferons; D051379:Mice; D009369:Neoplasms / Q000473:pathology; D010750:Phosphoproteins / Q000737:chemistry; D017346:Protein Serine-Threonine Kinases / Q000737:chemistry; D012097:Repressor Proteins; D014157:Transcription Factors; D019892:eIF-2 Kinase; D000099185:Interferon Regulatory Factor-8
D000970:Antineoplastic Agents; D002352:Carrier Proteins; D004268:DNA-Binding Proteins; D050856:Interferon Regulatory Factor-1; D050836:Interferon Regulatory Factor-2; D050835:Interferon Regulatory Factors; D007372:Interferons; D010750:Phosphoproteins; D017346:Protein Serine-Threonine Kinases; D012097:Repressor Proteins; D014157:Transcription Factors; D019892:eIF-2 Kinase; D000099185:Interferon Regulatory Factor-8; C494257:IRF1 protein, human; C494229:IRF2 protein, human; C494258:Irf1 protein, mouse; C494230:Irf2 protein, mouse