An atypical verrucous carcinoma of the tongue arising in a patient with oral lichen planus associated with hepatitis C virus infection.
Recently, a clinical relationship between oral lichen planus (OLP) and hepatitis C virus (HCV) infection has been suggested, but the role of this virus on the course of OLP is unknown. We report an unusual lingual localisation of verrucous carcinoma arising in a patient with histologically confirmed OLP and HCV infection diagnosed with second generation enzyme-linked immunosorbent assay and recombinant immunoblot assay. Serum HCV-RNA detected using nested reverse transcriptase polymerase chain reaction (RT-PCR) confirm HCV replication. No classical risk factors associated with verrucous carcinoma were present.
Carrozzo
M
M
Department of Oral Medicine and Periodontology, School of Medicine and Dentistry, University of Turin, Italy.
Carbone
M
M
Gandolfo
S
S
Valente
G
G
Colombatto
P
P
Ghisetti
V
V
D000368:Aged; D018289:Carcinoma, Verrucous / Q000821:virology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006526:Hepatitis C / Q000150:complications*; D006801:Humans; D015151:Immunoblotting; D017676:Lichen Planus, Oral / Q000821:virology*; D016133:Polymerase Chain Reaction / Q000379:methods; D012194:RNA-Directed DNA Polymerase; D014062:Tongue Neoplasms / Q000821:virology*
D012194:RNA-Directed DNA Polymerase