The development of congestive cardiac failure in a patient with hairy cell leukemia treated with 2-chlorodeoxyadenosine.
Deoxyadenosines are closely related to adenosine and as such, may interfere with the cardiac adenylate cyclase pathway resulting in cardiac dysfunction. We report a rare case of a 42 year old man who developed transient cardiac failure following treatment with 2-CDA for hairy cell leukemia.
Koczwara
B
B
Division of Medicine, Roswell Park Cancer Institute, Buffalo, New York, USA.
Spangenthal
E
E
Bernstein
S H
SH
D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use*; D017338:Cladribine / Q000009:adverse effects* / Q000627:therapeutic use*; D006333:Heart Failure / Q000139:chemically induced*; D006801:Humans; D007943:Leukemia, Hairy Cell / Q000150:complications / Q000188:drug therapy*; D008297:Male
D000970:Antineoplastic Agents; D017338:Cladribine