How does interferon exert its cell growth inhibitory effect?
The interferons (IFNs) have become accepted therapy in a range of haematological and non-haematological malignancies. The mechanism behind IFN's antitumour action is, however, unclear. Interferons (IFNs) are capable of modulating a variety of cellular responses. One prominent effect of IFNs is their cell growth inhibitory activity, which has also been suggested to be of major importance in their antitumour action. In the present review we will discuss the cellular events leading to a decreased number of cells following IFN treatment, the molecular mechanisms underlying these phenomena, and the importance of these effects in a clinical perspective.
Grandér
D
D
Department of Oncology-Pathology, Karolinska Hospital, Stockholm, Sweden. dan@deptonc.ks.se
Sangfelt
O
O
Erickson
S
S
D017209:Apoptosis; D002453:Cell Cycle / Q000187:drug effects / Q000502:physiology; D018797:Cell Cycle Proteins / Q000187:drug effects / Q000235:genetics; D002455:Cell Division / Q000187:drug effects*; D005057:Eukaryotic Cells / Q000502:physiology; D005786:Gene Expression Regulation; D007372:Interferons / Q000494:pharmacology* / Q000502:physiology
D018797:Cell Cycle Proteins; D007372:Interferons