title: Electrostatic interaction of myristoylated proteins with membranes: simple physics, complicated biology.
abstract: Cell membrane association by several important peripheral proteins, such as Src, MARCKS, HIV-1 Gag, and K-Ras, requires nonspecific electrostatic interactions between a cluster of basic residues on the protein and acidic phospholipids in the plasma membrane. A simple theoretical model based on the nonlinear Poisson-Boltzmann equation describes well the experimentally measured electrostatic association between such proteins and the cell membrane.
authors.affiliation: Department of Physiology and Biophysics, SUNY Stony Brook 11794-8661, USA.
authors.forename: D
authors.initials: D
authors.lastname: Murray
authors.forename: N
authors.initials: N
authors.lastname: Ben-Tal
authors.forename: B
authors.initials: B
authors.lastname: Honig
authors.forename: S
authors.initials: S
authors.lastname: McLaughlin
mesh_terms: D000595:Amino Acid Sequence; D002462:Cell Membrane / Q000737:chemistry*; D006801:Humans; D008969:Molecular Sequence Data; D019814:Myristic Acid; D009227:Myristic Acids / Q000737:chemistry*; D017711:Nonlinear Dynamics; D011506:Proteins / Q000737:chemistry*; D055672:Static Electricity
chemical_list: D009227:Myristic Acids; D011506:Proteins; D019814:Myristic Acid