Comparison of growth rate of two B16 melanomas differing in metastatic potential in young versus middle-aged mice.
The rise of cancer frequency as a function of age is a well-established fact. The aspect of the host age-tumor progression relationship, namely the slower metastatic spread in aged patients, has been investigated to a lesser extent. In the present study, we examined whether host-age-dependent growth rate varies with metastatic capacity of the tumor. The parental B16 and the B16/Col/R, a highly metastatic variant, were employed. A more pronounced growth of both tumors in young as compared to middle-aged mice was found. However, the differential growth in middle-aged versus young mice was more evident in the highly metastatic variant. According to the tumor size data, a sixfold growth reduction in middle-aged mice was observed with B16/Col/R and an only twofold growth reduction was seen with the B16 melanoma. The data might eventually contribute to the finding of more appropriate treatment modalities for the middle-aged cancer patient.
Donin
N
N
Department of Pathology, Sackler Faculty of Medicine, Tel-Aviv University, Israel.
Sinai
J
J
Staroselsky
A
A
Mahlin
T
T
Nordenberg
J
J
Leibovici
J
J
D000375:Aging / Q000502:physiology*; D000818:Animals; D002455:Cell Division / Q000502:physiology; D008297:Male; D008546:Melanoma, Experimental / Q000473:pathology* / Q000556:secondary*; D051379:Mice; D008810:Mice, Inbred C57BL; D009362:Neoplasm Metastasis; D010641:Phenotype