["Limited" cancers of the glottic stage of the larynx and exclusive chemotherapy--15 years of experience].
A retrospective analysis of the files of 25 patients with an early glottic well-differentiated untreated invasive squamous cell carcinoma, staged as T1-T2-NO with a complete response after cisplatin-fluorouracil neo-adjuvant chemotherapy, managed with exclusive chemotherapy is presented. Five-year actuarial (Kaplan-Meier method) survival and local control estimate was 83.8% and 33.6%, respectively. Patients with local recurrence after exclusive chemotherapy were always salvaged with partial laryngeal surgery or radiation therapy resulting in an overall 100% local control and laryngeal preservation rate. Five-year actuarial nodal recurrence distant metastasis, and metachronous second primary estimate was 0%, 0% and 20.2%, respectively.
Laccourreye
H
H
Service d'Oto-Rhino-Laryngologie et de Chirurgie Cervico-faciale, Hôpital Laennec, Paris.
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D005931:Glottis; D006801:Humans; D007822:Laryngeal Neoplasms / Q000188:drug therapy*; D012189:Retrospective Studies