Human colonic microvascular endothelial cells is a model of inflammatory bowel disease.
BACKGROUND
The pathophysiology of inflammatory bowel disease remains elusive primarily because of the limitations of the models available for study in the basic science laboratories. We propose a new model for the study of inflammatory bowel disease.


METHODS
Research and review articles published in the English literature.


CONCLUSIONS
The human colonic microvascular endothelial cell in culture is a legitimate model for the study of the human colon in the normal and diseased states.
Welton
M L
ML
Department of Surgery, University of California, San Francisco 94143-0144, USA.
D001920:Bradykinin / Q000502:physiology; D003106:Colon / Q000098:blood supply*; D016228:Endothelial Growth Factors / Q000502:physiology; D004730:Endothelium, Vascular / Q000166:cytology* / Q000502:physiology; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000503:physiopathology*; D008833:Microcirculation / Q000166:cytology / Q000502:physiology; D008954:Models, Biological; D013373:Substance P / Q000502:physiology
D016228:Endothelial Growth Factors; D013373:Substance P; D001920:Bradykinin