title: Acoustic voice analysis in patients with Parkinson's disease treated with dopaminergic drugs.
abstract: To quantify several acoustic features of the voice in patients with Parkinson's disease (PD), 41 patients and 28 age and sex-matched controls were studied. PD severity was assessed with the Unified PD Rating Scale (UPDRS) and the Hoehn and Yahr staging. The Computerized Speech Lab 4300 program (Kay Elemetrics) was used. Two seconds of a sustained /a/ and a sentence were captured with a microphone and laryngograph equipment. Measures included fundamental frequency (F0), frequency perturbation (jitter), intensity perturbation (shimmer), and harmonic/noise ratio (H/N) of the vowel /a/, and frequency and intensity variability of a sentence, phonational range, dynamic range at the natural frequency, maximum phonational time and s/z ratio. All subjects underwent indirect laryngoscopy and/or laryngeal fibroscopy. When compared with controls, PD patients showed higher jitter, lower H/N ratio, lower frequency and intensity variability of the sentence, and lower phonational range and reported a higher frequency of the presence of low voice-intensity, monopitch, voice arrests, and struggle. These features seem to be unaffected by the duration and severity of the disease.
authors.affiliation: Department of Otolaryngology, Hospital Universitario Príncipe de Asturias, Alcalá de Henares, Madrid, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Gamboa
authors.forename: F J
authors.initials: FJ
authors.lastname: Jiménez-Jiménez
authors.forename: A
authors.initials: A
authors.lastname: Nieto
authors.forename: J
authors.initials: J
authors.lastname: Montojo
authors.forename: M
authors.initials: M
authors.lastname: Ortí-Pareja
authors.forename: J A
authors.initials: JA
authors.lastname: Molina
authors.forename: E
authors.initials: E
authors.lastname: García-Albea
authors.forename: I
authors.initials: I
authors.lastname: Cobeta
mesh_terms: D000368:Aged; D015259:Dopamine Agents / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000150:complications* / Q000188:drug therapy*; D013061:Speech Acoustics; D014832:Voice Disorders / Q000150:complications*; D014833:Voice Quality
chemical_list: D015259:Dopamine Agents