[Adhesive molecules as drugs and objects of pharmacological effect in myocardial ischemia and reperfusion].
The modern advancements in the study of the mechanisms of reperfusion damage in myocardial infarction are analysed. Emphasis is placed on the leukocyte-endothelial interactions and the role of various adhesive molecules and cytokines. The effect of various biotechnological agents and drugs, products of chemical synthesis, on some links of the reperfusion syndrome are discussed. A classification of substances possessing a protective effect in ischemia/reperfusion is proposed.
Uteshev
D B
DB
Uteshev
B S
BS
D000818:Animals; D015815:Cell Adhesion Molecules / Q000494:pharmacology / Q000627:therapeutic use*; D004730:Endothelium, Vascular / Q000166:cytology / Q000378:metabolism; D006801:Humans; D007378:Interleukins / Q000378:metabolism; D008214:Lymphocytes / Q000166:cytology / Q000378:metabolism; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D017202:Myocardial Ischemia / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D015428:Myocardial Reperfusion Injury / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D010972:Platelet Activating Factor / Q000378:metabolism; D013929:Thromboxane B2 / Q000378:metabolism
D015815:Cell Adhesion Molecules; D007378:Interleukins; D010972:Platelet Activating Factor; D013929:Thromboxane B2