title: Neokyotorphin and neokyotorphin (1-4): secretion by erythrocytes and regulation of tumor cell growth.
abstract: Human erythrocytes release neokyotorphin, the 137-141 fragment of hemoglobin alpha-chain into the supernatant of red blood cells primary culture. However, the neokyotorphin fragment 1-4 that is formed together with neokyotorphin inside the red blood cells and in various tissues is not found in the supernatant. Both neokyotorphin and its 1-4 fragment were shown to stimulate proliferation of L929 tumor cells.
authors.affiliation: Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry Russian Academy of Sciences, Moscow.
authors.forename: E Y
authors.initials: EY
authors.lastname: Blishchenko
authors.forename: O A
authors.initials: OA
authors.lastname: Mernenko
authors.forename: O N
authors.initials: ON
authors.lastname: Yatskin
authors.forename: R H
authors.initials: RH
authors.lastname: Ziganshin
authors.forename: M M
authors.initials: MM
authors.lastname: Philippova
authors.forename: A A
authors.initials: AA
authors.lastname: Karelin
authors.forename: V T
authors.initials: VT
authors.lastname: Ivanov
mesh_terms: D002455:Cell Division / Q000187:drug effects*; D002851:Chromatography, High Pressure Liquid; D004723:Endorphins / Q000378:metabolism* / Q000494:pharmacology; D004912:Erythrocytes / Q000378:metabolism*; D006801:Humans; D010446:Peptide Fragments / Q000378:metabolism* / Q000494:pharmacology; D017421:Sequence Analysis; D014407:Tumor Cells, Cultured
chemical_list: D004723:Endorphins; D010446:Peptide Fragments; C100744:neokyotorphin (1-4); C036450:neo-kyotorphin