Changes in amyloid precursor protein and apolipoprotein E immunoreactivity following ischemic brain injury in rat with long-term survival: influence of idebenone treatment.
We observed in extra- and intracellular space accumulation of different fragments of amyloid precursor protein (APP) and apolipoprotein E (Apo E) in rat brain after cardiac arrest with long-term survival. Idebenone treatment did not affect APP and Apo E alterations in this condition.
Pluta
R
R
Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland.
Barcikowska
M
M
Debicki
G
G
Ryba
M
M
Januszewski
S
S
D016229:Amyloid beta-Peptides / Q000378:metabolism; D016564:Amyloid beta-Protein Precursor / Q000378:metabolism*; D000818:Animals; D001057:Apolipoproteins E / Q000378:metabolism*; D016227:Benzoquinones / Q000494:pharmacology*; D002545:Brain Ischemia / Q000378:metabolism*; D002540:Cerebral Cortex / Q000098:blood supply / Q000378:metabolism; D005260:Female; D006624:Hippocampus / Q000098:blood supply / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D014451:Ubiquinone / Q000031:analogs & derivatives
D016229:Amyloid beta-Peptides; D016564:Amyloid beta-Protein Precursor; D001057:Apolipoproteins E; D016227:Benzoquinones; D014451:Ubiquinone; C036619:idebenone