Pericarditis induced by high-dose cytosine arabinoside chemotherapy.
Pericarditis is a rare side effect of chemotherapy. We report here the case of a patient treated with high-dose cytosine arabinoside (HD ara-c) who developed severe pericarditis. Interruption of HD ara-c and initiation of corticosteroid treatment were effective in resolving the pericardial effusion. This case illustrates this rare but potentially life-threatening cardiac complication of HD ara-c therapy as well as the beneficial effect of corticosteroid treatment.
Hermans
C
C
Hematology Department, Cliniques Universitaires Saint-Luc, Catholic University of Louvain, Brussels, Belgium.
Straetmans
N
N
Michaux
J L
JL
Ferrant
A
A
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003561:Cytarabine / Q000008:administration & dosage / Q000009:adverse effects*; D003630:Daunorubicin / Q000008:administration & dosage; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000150:complications / Q000188:drug therapy / Q000532:radiotherapy; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D008942:Mitoxantrone / Q000008:administration & dosage; D010493:Pericarditis / Q000139:chemically induced* / Q000150:complications / Q000188:drug therapy; D012074:Remission Induction
D003561:Cytarabine; D008942:Mitoxantrone; D008775:Methylprednisolone; D003630:Daunorubicin