title: Isolation and structure elucidation of 7,8-dideoxy-6-oxo-griseorhodin C produced by Actinoplanes ianthinogenes.
abstract: A novel product, isolated from a culture broth of Actinoplanes ianthinogenes fermented for producing purpuromycin, was purified and its structure established on the basis of physico-chemical data and chemical reactions. The new product resulted to be structurally related to griseorhodins, a group of hydroquinonic antibiotics obtained from Streptomyces californicus. This compound showed a weak activity against Gram-positive and resulted inactive against Gram-negative bacteria and Candida albicans.
authors.affiliation: Biosearch Italia S.p.A., Gerenzano (VA) Italia.
authors.forename: G
authors.initials: G
authors.lastname: Panzone
authors.forename: A
authors.initials: A
authors.lastname: Trani
authors.forename: P
authors.initials: P
authors.lastname: Ferrari
authors.forename: L
authors.initials: L
authors.lastname: Gastaldo
authors.forename: L
authors.initials: L
authors.lastname: Colombo
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D005285:Fermentation; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009285:Naphthoquinones / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D013141:Spiro Compounds / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: C108553:7,8-dideoxy-6-oxogriseorhodin C; D000900:Anti-Bacterial Agents; D009285:Naphthoquinones; D013141:Spiro Compounds; C009115:purpuromycin