title: Expression of several members of the TNF-ligand and receptor family on tonsillar lymphoid B cells.
abstract: Although the expression patterns of the members of the tumour necrosis factor receptor and ligand families have extensively been studied by flow-cytometry on stimulated peripheral blood mononuclear cells (PBMNC), little or no flow-cytometric or immunohistological data exist about their expression in lymphoid tissue. According to the data obtained from stimulated PBMNC, several members of these molecule families (e.g. CD40 ligand [CD40L], CD30, CD27, hOX40) have been considered to be either T-cell restricted or strongly T-cell associated. The present study on samples from palatine tonsils revealed that most of these molecules are also expressed by tonsillar B cells. The additional analysis of the co-expression of these molecules also disclosed the existence of CD40+/CD40L+ and CD27+/CD70+ (CD27L+) lymphoid cells in tonsillar tissue.
authors.affiliation: Institute of Pathology, Universitätsklinikum Benjamin Franklin, Berlin, Germany.
authors.forename: H
authors.initials: H
authors.lastname: Dürkop
authors.forename: I
authors.initials: I
authors.lastname: Anagnostopoulos
authors.forename: S
authors.initials: S
authors.lastname: Bulfone-Paus
authors.forename: H
authors.initials: H
authors.lastname: Stein
mesh_terms: D015703:Antigens, CD / Q000378:metabolism; D001402:B-Lymphocytes / Q000378:metabolism*; D005434:Flow Cytometry; D006801:Humans; D007150:Immunohistochemistry; D008024:Ligands; D014066:Palatine Tonsil / Q000276:immunology; D018124:Receptors, Tumor Necrosis Factor / Q000378:metabolism*; D013601:T-Lymphocytes / Q000378:metabolism
chemical_list: D015703:Antigens, CD; D008024:Ligands; D018124:Receptors, Tumor Necrosis Factor