title: Biochemical differences between three subcell-lines derived from SV40-transformed hamster lens cells.
abstract: Clones derived from SV40-transformed hamster lens cells have at least three different stable morphologies. Biochemical differences between the three cell types that become detectable after transfection of the alpha A-crystallin gene do exist at the level of alpha B-crystallin and small heat shock protein (HSP27) expression. Furthermore one cell type is capable of alternative splicing of the hamster alpha A-crystallin gene, whereas another one cannot express alpha AIns-crystallin.
authors.affiliation: Department of Biochemistry, University of Nijmegen, The Netherlands.
authors.forename: H
authors.initials: H
authors.lastname: Bloemendal
authors.forename: J H
authors.initials: JH
authors.lastname: Enzlin
authors.forename: A A
authors.initials: AA
authors.lastname: Van Rijk
authors.forename: H J
authors.initials: HJ
authors.lastname: Jansen
mesh_terms: D000818:Animals; D002461:Cell Line, Transformed / Q000166:cytology / Q000378:metabolism*; D002472:Cell Transformation, Viral; D006224:Cricetinae; D003459:Crystallins / Q000235:genetics / Q000378:metabolism; D015870:Gene Expression; D006360:Heat-Shock Proteins / Q000378:metabolism; D007908:Lens, Crystalline / Q000166:cytology / Q000378:metabolism*; D013539:Simian virus 40; D014162:Transfection
chemical_list: D003459:Crystallins; D006360:Heat-Shock Proteins