Central administration of FMRFamide produces antipsychotic-like effects in rodents.
Neuropeptide FMRFamide (Phe-Met-Arg-Phe-NH2) was evaluated in animal models of psychosis. FMRFamide (0.5-100 micrograms, i.c.v.) produced blockade of conditioned avoidance response in rats and antagonized apomorphine-induced climbing behaviour in mice. Similarly, FMRFamide at lower doses (0.1-10 micrograms, i.c.v.) inhibited 5-hydroxy-L-tryptophan (5-HTP)-induced head twitches in rats. These effects of the peptide were similar to haloperidol (1 mg/kg, i.p.). However, unlike haloperidol, FMRFamide per se did not induce any catalepsy in rats at the doses employed in the above paradigms. These results indicate antipsychotic-like activity for the neuropeptide FMRFamide with possible involvement of the dopaminergic/5-HT2 systems.
Muthal
A V
AV
Department of Pharmaceutical Sciences, Nagpur University Campus, India.
Mandhane
S N
SN
Chopde
C T
CT
D006916:5-Hydroxytryptophan / Q000494:pharmacology; D000818:Animals; D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D001058:Apomorphine / Q000494:pharmacology; D001362:Avoidance Learning / Q000187:drug effects; D001522:Behavior, Animal / Q000187:drug effects; D002375:Catalepsy / Q000517:prevention & control; D003216:Conditioning, Operant / Q000187:drug effects; D019835:FMRFamide / Q000008:administration & dosage / Q000494:pharmacology*; D007276:Injections, Intraventricular; D008297:Male; D051379:Mice; D051381:Rats; D017208:Rats, Wistar; D013238:Stereotaxic Techniques
D014150:Antipsychotic Agents; D019835:FMRFamide; D006916:5-Hydroxytryptophan; D001058:Apomorphine