title: Non-alcoholic duct destructive chronic pancreatitis.
abstract: BACKGROUND
  The pathology of non-alcoholic chronic pancreatitis has not yet been sufficiently studied.
  
  
  OBJECTIVE
  To identify the major changes of pancreatic tissue in patients surgically treated for non-alcoholic chronic pancreatitis.
  
  
  METHODS
  Pancreatectomy specimens from 12 patients with non-alcoholic chronic pancreatitis, including four patients with autoimmune or related diseases (Sjögren's syndrome, primary sclerosing cholangitis, ulcerative colitis, and Crohn's disease), were reviewed.
  
  
  METHODS
  Morphological changes were studied histologically and immunohistochemically (to type inflammatory cells) and compared with the pancreatic alterations found in 12 patients with alcoholic chronic pancreatitis.
  
  
  RESULTS
  In patients with non-alcoholic chronic pancreatitis, with or without associated autoimmune or related diseases, pancreatic inflammation particularly involved the ducts, commonly resulting in duct obstruction and occasionally duct destruction. None of these features was seen in alcoholic chronic pancreatitis which, however, showed pseudocysts and calcifications.
  
  
  CONCLUSIONS
  The pancreatic changes in patients with non-alcoholic chronic pancreatitis clearly differ from those with alcoholic chronic pancreatitis. The term chronic duct destructive pancreatitis is suggested for this type of pancreatic disease.
authors.affiliation: Department of Pathology, Catholic University Leuven, Belgium.
authors.forename: N
authors.initials: N
authors.lastname: Ectors
authors.forename: B
authors.initials: B
authors.lastname: Maillet
authors.forename: R
authors.initials: R
authors.lastname: Aerts
authors.forename: K
authors.initials: K
authors.lastname: Geboes
authors.forename: A
authors.initials: A
authors.lastname: Donner
authors.forename: F
authors.initials: F
authors.lastname: Borchard
authors.forename: P
authors.initials: P
authors.lastname: Lankisch
authors.forename: M
authors.initials: M
authors.lastname: Stolte
authors.forename: J
authors.initials: J
authors.lastname: Lüttges
authors.forename: B
authors.initials: B
authors.lastname: Kremer
authors.forename: G
authors.initials: G
authors.lastname: Klöppel
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001327:Autoimmune Diseases / Q000473:pathology* / Q000601:surgery; D002908:Chronic Disease; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D010183:Pancreatic Ducts / Q000473:pathology*; D010195:Pancreatitis / Q000473:pathology* / Q000601:surgery; D019512:Pancreatitis, Alcoholic / Q000473:pathology / Q000601:surgery