Lights out: deactivation of the phototransduction cascade.
The phototransduction G-protein-coupled signaling cascade is an extremely rapid response to photons of light. Equally important to activation of signaling is switching the signal off. A variety of strategies, ranging from the action of kinases and phosphatases, to feedback regulation by substrates and small molecules, ensures efficient inactivation. Here, we focus on phototransduction in Drosophila as a paradigm for the study of deactivation in a complex G-protein-coupled signaling pathway in vivo.
Scott
K
K
Department of Biology, University of California, San Diego, La Jolla 92093, USA.
Zuker
C
C
D000818:Animals; D002118:Calcium / Q000378:metabolism; D004330:Drosophila; D019204:GTP-Binding Proteins / Q000378:metabolism; D007473:Ion Channels / Q000378:metabolism; D008954:Models, Biological; D010770:Phosphotransferases / Q000378:metabolism; D017956:Photoreceptor Cells, Invertebrate / Q000502:physiology; D014785:Vision, Ocular / Q000502:physiology*
D007473:Ion Channels; D010770:Phosphotransferases; D019204:GTP-Binding Proteins; D002118:Calcium