title: Molecular evolution of myelin proteolipid protein.
abstract: We show that the major membrane protein of central nervous system myelin, proteolipid protein, evolved much more rapidly than it does now more than 300 million years ago. We reason that myelin proteolipid protein evolved rapidly just after its appearance in vertebrates and that its evolutionary rate then gradually decreased. Comparison of the rates between the synonymous and nonsynonymous nucleotide substitutions for the cDNA suggests the possibility that positive selection operated on myelin proteolipid protein at least when it appeared in vertebrates.
authors.affiliation: Institute of Life Science, Soka University, Tokyo, Japan. kurihara@t.soka.ac.jp
authors.forename: T
authors.initials: T
authors.lastname: Kurihara
authors.forename: M
authors.initials: M
authors.lastname: Sakuma
authors.forename: T
authors.initials: T
authors.lastname: Gojobori
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D017124:Conserved Sequence; D003574:Cytochrome c Group / Q000737:chemistry / Q000235:genetics; D018076:DNA, Complementary; D019143:Evolution, Molecular; D005399:Fishes; D005580:Fossils; D014644:Genetic Variation; D006801:Humans; D007798:Lampreys; D008322:Mammals; D051379:Mice; D008969:Molecular Sequence Data; D018991:Myelin Proteolipid Protein / Q000737:chemistry / Q000235:genetics*; D051381:Rats; D013995:Time; D014714:Vertebrates
chemical_list: D003574:Cytochrome c Group; D018076:DNA, Complementary; D018991:Myelin Proteolipid Protein