Duration of protective immunity against ovine haemonchosis following vaccination with the nematode gut membrane antigen H11.
To establish for how long protective antibody levels may be maintained, lambs were vaccinated with the gut membrane antigen H11 and challenged with Haemonchus contortus 14, 84, 126 or 168 days later. Compared to controls, mean faecal egg counts of vaccinated lambs were reduced by 97 per cent, 99 per cent, 92 per cent and 86 per cent respectively. Total worm burdens at postmortem five weeks after infection were reduced by 87 per cent, 94 per cent, 92 per cent and 62 per cent respectively. In vaccinated lambs, antibody levels to H11 peaked at about 60 days after the first vaccination and were maintained for the duration of the experiment. There was evidence of secondary antibody responses to H11 following challenge.
Andrews
S J
SJ
Mallinckrodt Veterinary Ltd., Harefield, Uxbridge.
Rolph
T P
TP
Munn
E A
EA
D000818:Animals; D000947:Antigens, Helminth / Q000008:administration & dosage* / Q000276:immunology / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D005243:Feces / Q000469:parasitology; D005260:Female; D006188:Haemonchiasis / Q000276:immunology / Q000517:prevention & control / Q000662:veterinary*; D006189:Haemonchus / Q000276:immunology* / Q000302:isolation & purification; D008297:Male; D010270:Parasite Egg Count / Q000662:veterinary; D011897:Random Allocation; D012756:Sheep; D012757:Sheep Diseases / Q000276:immunology / Q000469:parasitology / Q000517:prevention & control*; D013997:Time Factors; D014611:Vaccination / Q000379:methods / Q000662:veterinary*; D014612:Vaccines / Q000008:administration & dosage* / Q000276:immunology
D000947:Antigens, Helminth; D014612:Vaccines