Cerebral infarction in patients with AIDS.
OBJECTIVE
To establish the frequency, distribution, and pathogenesis of cerebral infarction as confirmed with MR imaging in a cohort of patients with acquired immunodeficiency syndrome (AIDS).


METHODS
We reviewed all (71) abnormal cranial MR studies obtained at our institution in human immunodeficiency virus (HIV)-positive patients over a 2-year period and recorded the number and distribution of ischemic lesions, any associated abnormalities, and the MR angiographic findings, where available. Patients' charts were studied for relevant clinical data, biochemical and culture results, and potential etiologic factors.


RESULTS
Twenty-two infarcts were seen in 13 of the 71 patients. Of these 22, the basal ganglia area was affected in 15, the middle cerebral artery territory in two, and the vertebrobasilar territory in five. Five patients had concomitant evidence of infection, six others used cocaine or were intravenous drug abusers. MR angiography was performed in eight patients; two of these had multiple lesions consistent with vasculitis, two had isolated lesions that corresponded with their parenchymal infarct, and four had normal findings.


CONCLUSIONS
The frequency of infarction was 18%, higher than previously reported. The pathogenesis of infarction was multifactorial. Underlying infectious causes were identified in 39% of patients. Two patients had an idiopathic vasculitis.
Gillams
A R
AR
Department of Radiology, Boston University Medical School, MA, USA.
Allen
E
E
Hrieb
K
K
Venna
N
N
Craven
D
D
Carter
A P
AP
D015526:AIDS Dementia Complex / Q000175:diagnosis* / Q000473:pathology; D017088:AIDS-Related Opportunistic Infections / Q000175:diagnosis* / Q000473:pathology; D000328:Adult; D001921:Brain / Q000473:pathology; D001927:Brain Diseases / Q000175:diagnosis* / Q000473:pathology; D002544:Cerebral Infarction / Q000175:diagnosis* / Q000473:pathology; D015331:Cohort Studies; D005260:Female; D006679:HIV Seropositivity / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged