PET studies of functional compensation in a primate model of Parkinson's disease.
MPTP 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine is a neurotoxin that produces degeneration of nigrostriatal dopaminergic neurons and a chronic parkinsonian condition in primates. Positron emission tomography (PET) studies of rhesus macaques at various time points following unilateral MPTP administration demonstrated a different time course of degeneration in the dopaminergic terminals in the putamen and in the cell bodies in the substantia nigra, consistent with other evidence of retrograde degeneration. In addition, the substantia nigra showed a transient upregulation in dopaminergic function in the lesioned hemisphere indicating functional compensation. This plasticity has important implications for the therapeutic effects of growth factors and other potential treatments for neurodegenerative diseases.
Eberling
J L
JL
Center for Functional Imaging, Lawrence Berkeley National Laboratory, University of California, Berkeley 94720, USA.
Bankiewicz
K S
KS
Jordan
S
S
VanBrocklin
H F
HF
Jagust
W J
WJ
D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine / Q000037:antagonists & inhibitors; D000818:Animals; D003342:Corpus Striatum / Q000000981:diagnostic imaging* / Q000187:drug effects; D018450:Disease Progression; D015259:Dopamine Agents; D005462:Fluorine Radioisotopes; D008253:Macaca mulatta; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology; D018696:Neuroprotective Agents / Q000494:pharmacology; D009498:Neurotoxins / Q000037:antagonists & inhibitors; D010293:Pargyline / Q000494:pharmacology; D010302:Parkinson Disease, Secondary / Q000000981:diagnostic imaging*; D014055:Tomography, Emission-Computed; D014443:Tyrosine / Q000031:analogs & derivatives
D015259:Dopamine Agents; D005462:Fluorine Radioisotopes; D008996:Monoamine Oxidase Inhibitors; D018696:Neuroprotective Agents; D009498:Neurotoxins; C080704:6-fluoro-3-tyrosine; D014443:Tyrosine; D010293:Pargyline; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine