[Effect of oral inulin administration on the fructose 2,6-biphosphate level in the liver tissue of rats with streptozocin diabetes].
The influence of oral inulin administration on glucose and fructose content in blood, glucose and ketone bodies in urine, and fructose-2,6-diphosphate content in liver was investigated in rats with streptozotocin diabetes. Short-term administration (during 5-6 days) of 0.5% inulin solution caused three-fold increase of blood fructose compared with control, normalisation of blood glucose and disappearance of glucose- and ketoneuria. The level of fructose-2,6-di-phosphate in liver increased to the control level. Inulin administration during 12 days caused five-fold increase of blood fructose compares with control, glucose level increased up to the level of uncurred diabetes (22 mmol/1), glucose- and ketoneuria appeared. The content of fructose-2,6-diphosphate in the liver decreased to diabetic level.
Guseva
D A
DA
Gorodetskiĭ
V K
VK
Kraevoĭ
S A
SA
Markova
M S
MS
Tsyganova
T B
TB
D000284:Administration, Oral; D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D005635:Fructosediphosphates / Q000378:metabolism*; D007444:Inulin / Q000008:administration & dosage / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D005635:Fructosediphosphates; C027652:fructose 2,6-diphosphate; D007444:Inulin