title: Transient reverse ventilation-perfusion mismatch in acute pulmonary nitrofurantoin reaction.
abstract: A 67-yr-old woman with a history of myocardial infarct was admitted to emergency for marked dyspnea, nonproductive cough, nausea and fever. The thorax X-ray revealed a bilateral alveolar and interstitial infiltration pattern with basal accentuation. The cardiac examinations were normal. Technegas ventilation and Tc-99m-macroaggregated albumin (MAA) perfusion scans were performed to rule out pulmonary embolism. Bilateral multiple ventilation defects with normal perfusion was observed. The patient had been taking nitrofurantoin for four days for a bladder infection. Hypersensitivity to nitrofurantoin was suspected and the drug was discontinued. An antihistaminic and anxiolytic medication was started. The majority of the clinical symptoms disappeared within 24 hours. The control chest X-rays disclosed a marked improvement. Ventilation and perfusion scans obtained 48 hours after nitrofurantoin withdrawal were normal. The drug-related pulmonary reactions should be taken into account in patients on medication. Reversible ventilation defects can be the only lung-scintigraphic finding encountered in acute pulmonary nitrofurantoin reaction.
authors.affiliation: Ondokuz Mayts University Hospital, Department of Nuclear Medicine, Samsun, Turkey.
authors.forename: T
authors.initials: T
authors.lastname: Başoğlu
authors.forename: L
authors.initials: L
authors.lastname: Erkan
authors.forename: F
authors.initials: F
authors.lastname: Canbaz
authors.forename: I
authors.initials: I
authors.lastname: Bernay
authors.forename: T
authors.initials: T
authors.lastname: Onen
authors.forename: M
authors.initials: M
authors.lastname: Sahin
authors.forename: F
authors.initials: F
authors.lastname: Furtun
authors.forename: T
authors.initials: T
authors.lastname: Yalin
mesh_terms: D000368:Aged; D000892:Anti-Infective Agents, Urinary / Q000009:adverse effects* / Q000494:pharmacology; D005260:Female; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging / Q000187:drug effects*; D009582:Nitrofurantoin / Q000009:adverse effects* / Q000494:pharmacology; D012123:Pulmonary Ventilation / Q000187:drug effects*; D011859:Radiography; D011877:Radionuclide Imaging; D014692:Ventilation-Perfusion Ratio / Q000187:drug effects; D014965:X-Rays
chemical_list: D000892:Anti-Infective Agents, Urinary; D009582:Nitrofurantoin