title: 5-Fluorouracil derivatives. XXII. Synthesis and antitumor activities of 1-carbamoyl-5-fluorouracils.
abstract: Fifty-four 1-carbamoyl-5-fluorouracils were synthesized from 5-fluorouracil and isocyanate or amine. Antitumor activity was tested in the L-1210 tumor system, and 11 compounds gave better values of therapeutic ratio than HCFU (1-hexylcarbamoyl-5-fluorouracil). 1-(4-Methoxycyclohexylcarbamoyl)-5-fluorouracil gave the best result.
authors.affiliation: Department of Chemistry, Shandong University, Jinan, China.
authors.forename: S
authors.initials: S
authors.lastname: Ozaki
authors.forename: X
authors.initials: X
authors.lastname: Kong
authors.forename: Y
authors.initials: Y
authors.lastname: Watanabe
authors.forename: T
authors.initials: T
authors.lastname: Hoshiko
authors.forename: T
authors.initials: T
authors.lastname: Koga
authors.forename: T
authors.initials: T
authors.lastname: Ogasawara
authors.forename: T
authors.initials: T
authors.lastname: Takizawa
authors.forename: H
authors.initials: H
authors.lastname: Fujisawa
authors.forename: M
authors.initials: M
authors.lastname: Iigo
authors.forename: A
authors.initials: A
authors.lastname: Hoshi
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D005472:Fluorouracil / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D007939:Leukemia L1210 / Q000188:drug therapy; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains
chemical_list: D000970:Antineoplastic Agents; D005472:Fluorouracil