title: Negative signaling in B cells: SHIP Grbs Shc.
abstract: Negative signaling in B cells is initiated by co-crosslinking of the antigen receptor and the Fcy receptor, resulting in cessation of B-cell signaling events and, in turn, inhibiting B-cell proliferation and antibody secretion. Here, a competitive role is proposed for SHIP in blocking the interaction of Shc with the Grb2-Sos complex of proteins that lead to Ras activation in B cells.
authors.affiliation: Ohio State University, Dept of Microbiology, Columbus 43210, USA.
authors.forename: S
authors.initials: S
authors.lastname: Tridandapani
authors.forename: T
authors.initials: T
authors.lastname: Kelley
authors.forename: D
authors.initials: D
authors.lastname: Cooney
authors.forename: M
authors.initials: M
authors.lastname: Pradhan
authors.forename: K M
authors.initials: KM
authors.lastname: Coggeshall
mesh_terms: D000486:Allergy and Immunology / Q000639:trends; D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D006801:Humans; D008954:Models, Biological; D000072183:Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases; D010744:Phosphoric Monoester Hydrolases / Q000276:immunology; D015398:Signal Transduction / Q000276:immunology*; D018631:ras Proteins / Q000276:immunology; D018909:src Homology Domains / Q000276:immunology
chemical_list: D010744:Phosphoric Monoester Hydrolases; C098706:INPPL1 protein, human; D000072183:Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases; D018631:ras Proteins