[Mechanisms of pyrimidine derivatives systemic immunomodulating effect].
Experiments on guinea pigs showed that xymedon in a dose of 30 mg/kg stimulates nucleic acid synthesis in thymocytes and increases the blood serum nucleic acid content. Xymedon increased secretion of endogenous DNA by human lymphocytes stimulated with PNA in vitro. The systemic immunotropic mechanisms of pyrimidine derivatives are discussed.
Slabnov
Iu D
IuD
Cherepnev
G V
GV
Tsibulkin
A P
AP
Garaev
R S
RS
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D000918:Antibody Specificity / Q000187:drug effects; D004247:DNA / Q000378:metabolism; D006168:Guinea Pigs; D006801:Humans; D000960:Hypolipidemic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D011743:Pyrimidines / Q000008:administration & dosage / Q000494:pharmacology*; D012313:RNA / Q000378:metabolism; D013050:Spectrometry, Fluorescence; D013601:T-Lymphocytes / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D013950:Thymus Gland / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism
D000960:Hypolipidemic Agents; D011743:Pyrimidines; C069705:xymedon; D012313:RNA; D004247:DNA