Effects of apolipoprotein E on dementia and aging in the Shanghai Survey of Dementia.
We investigated the status of the apolipoprotein E allele in 538 participants in the incidence phase of the ongoing Shanghai Survey of Dementia, including 103 demented subjects, 72 with mild cognitive impairment and 363 cognitively normal. The apo E epsilon 4 allele was present in 10.2% of control subjects and the allelic frequency did not change between ages 60 to 96 years. The apo E epsilon 4 allelic frequency was increased both in those wiht Alzheimer's disease (AD) (25.4%) and those with vascular dementia (VaD) (22.2%), but not in those with other dementing illnesses or the cognitively impaired. All of the subjects homozygous for apo E epsilon 4 were demented, three were diagnosed as having AD, and three met NINDS/AIREN criteria for VaD. The increased apo E epsilon 4 allelic frequency in clinically diagnosed VaD patients suggests that some of the infarcts are secondary to congophilic angiopathy. The adjusted odds ratio of developing AD in this community-derived study for persons with at least one apo E epsilon 4 allele was 4.1 (95% CI: 2.2, 7.7). Thus, the apo E epsilon 4 risk of developing AD in this Chinese cohort is similar to that in western community studies.
Katzman
R
R
Alzheimer Disease Research Center, University of California at San Diego, La Jolla 92093-0949, USA.
Zhang
M Y
MY
Chen
P J
PJ
Gu
N
N
Jiang
S
S
Saitoh
T
T
Chen
X
X
Klauber
M
M
Thomas
R G
RG
Liu
W T
WT
Yu
E S
ES
D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000235:genetics*; D000483:Alleles; D000544:Alzheimer Disease / Q000453:epidemiology / Q000235:genetics; D001057:Apolipoproteins E / Q000235:genetics*; D002681:China / Q000453:epidemiology; D003072:Cognition Disorders / Q000453:epidemiology / Q000235:genetics; D015331:Cohort Studies; D003431:Cross-Cultural Comparison; D003704:Dementia / Q000453:epidemiology / Q000235:genetics*; D015140:Dementia, Vascular / Q000453:epidemiology / Q000235:genetics; D005787:Gene Frequency; D006801:Humans; D015994:Incidence; D008875:Middle Aged; D016017:Odds Ratio; D012307:Risk Factors; D012737:Sex Factors
D001057:Apolipoproteins E