Bromism: intoxication from a rare anticonvulsant therapy.
Bromide, the first effective therapy for epilepsy, is not commonly prescribed today but has been advocated by some pediatric neurologists for the treatment of intractable seizures in children. We report a 17-year-old female patient with intractable epilepsy who insidiously developed bromism while on treatment with triple bromide elixir. We review the clinical presentation, diagnosis, pathophysiology, and management of bromism.
James
L P
LP
Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, USA.
Farrar
H C
HC
Griebel
M L
ML
Bates
S R
SR
D000293:Adolescent; D000927:Anticonvulsants / Q000009:adverse effects*; D001965:Bromides / Q000009:adverse effects*; D003221:Confusion / Q000139:chemically induced; D004827:Epilepsy / Q000188:drug therapy; D005260:Female; D006801:Humans; D007508:Irritable Mood / Q000187:drug effects; D011041:Poisoning / Q000628:therapy; D013064:Speech Disorders / Q000139:chemically induced
D000927:Anticonvulsants; D001965:Bromides