Effect of sodium stibogluconate on hepatic mixed function oxidase system and marker enzymes of golden hamsters during Leishmania donovani infection.
During L. donovani infection in golden hamsters, tremendous hepatic damage was observed as apparent from increased activities of glutamate oxaloacetate transaminase, glutamate pyruvate transaminase, succinate dehydrogenase, glucose-6-phosphatase and acid ribonuclease. The levels of cytochrome P-450 and related monooxygenases, viz. aniline hydroxylase and aminopyrine-N-demethylase registered significant decrease in infected animals. Sodium stibogluconate, a standard antileishmanial drug, though caused the removal of parasites from infected tissues, but did not help in the recovery of deranged hepatic markers. The results explain the higher mortality of stibanate treated infected animals as compared to untreated animals infected with L. donovani.
Mittal
N
N
Division of Biochemistry, Central Drug Research Institute, Lucknow, India.
Gupta
N
N
Goyal
N
N
Singh
A K
AK
Guru
P Y
PY
Pandey
V C
VC
Rastogi
A K
AK
D000818:Animals; D000967:Antimony Sodium Gluconate / Q000494:pharmacology* / Q000633:toxicity; D000981:Antiprotozoal Agents / Q000494:pharmacology* / Q000633:toxicity; D006224:Cricetinae; D007893:Leishmania donovani; D007898:Leishmaniasis, Visceral / Q000188:drug therapy* / Q000201:enzymology; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008297:Male; D008647:Mesocricetus; D006899:Mixed Function Oxygenases / Q000378:metabolism
D000981:Antiprotozoal Agents; D006899:Mixed Function Oxygenases; D000967:Antimony Sodium Gluconate