Mercury induces multiple antibiotic resistance in Escherichia coli through activation of SoxR, a redox-sensing regulatory protein.
Sub-inhibitory mercury concentrations are capable of partially activating SoxR, as shown by the augmented expression of a soxS'::lacZ fusion, and a diminished sensitivity to antibiotics caused by mercury treatment. Mercury may elevate the intracellular concentration of superoxide or perhaps act as a putative metal ligand for SoxR.
Fuentes
A M
AM
Departamento de Microbiología, LUSARA, México, D.F., Mexico.
Amábile-Cuevas
C F
CF
D001426:Bacterial Proteins / Q000502:physiology*; D004352:Drug Resistance, Microbial; D018432:Drug Resistance, Multiple; D004926:Escherichia coli / Q000187:drug effects*; D008628:Mercury / Q000494:pharmacology*; D014157:Transcription Factors / Q000502:physiology*
D001426:Bacterial Proteins; D014157:Transcription Factors; C070724:SoxR protein, Bacteria; D008628:Mercury