[Determination of energetically significant parts of globulins and hierarchy of domain structure in macromolecules of proteins].
We have justified a Van der Waals approach for the problem of domains structure in globular proteins. A method for isolation of hierarchy of Van der Waals interactions in the space of protein globule has been found out. The definition of hierarchy's levels in the spatial structure of macromolecules is effected by the position of maxima in the distribution of potential energy of interactions. Multilevels system for domain structure organization of globular proteins and method for isolation of domains on different levels of energetical hierarchy has been established. Using this method we have revealed regions of different stability in 15 proteins globule.
Berezovskiĭ
I N
IN
Esipova
N G
NG
Tumanian
V G
VG
D005916:Globulins / Q000737:chemistry*; D008958:Models, Molecular; D011487:Protein Conformation
D005916:Globulins