Angiotensin II type I receptor polymorphism in African Americans lower frequency of the C1166 variant.
The C1166 variant, an A to C substitution polymorphism at the 1166 position of the angiotensin II type I (AT1) receptor, has been previously associated with hypertension in Caucasians. This study determines the frequency of the C1166 variant in an African American population. Normotensive African American (n = 99) and Caucasian (n = 100) subjects were genotyped to determine the frequency of the C1166 variant. This study establishes the frequency of the C1166 variant in African Americans (0.05 +/- 0.01) and demonstrates a significantly lower frequency in African Americans compared with Caucasians (0.05 vs. 0.25, respectively, chi 2 = 30.7, p < < 0.001, 1 df).
Gainer
J V
JV
Vanderbilt University Medical Center, Division of Clinical Pharmacology, Nashville, TN, USA. jay.gainer@mcmail.vanderbilt.edu
Hunley
T E
TE
Kon
V
V
Nadeau
J H
JH
Muldowney
J A
JA
Brown
N J
NJ
D000328:Adult; D044383:Black People / Q000235:genetics*; D005260:Female; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic; D044140:Receptor, Angiotensin, Type 1; D044139:Receptor, Angiotensin, Type 2; D011945:Receptors, Angiotensin / Q000235:genetics*; D044465:White People / Q000235:genetics; D001741:Black or African American
D044140:Receptor, Angiotensin, Type 1; D044139:Receptor, Angiotensin, Type 2; D011945:Receptors, Angiotensin