Killing kinetics of RP 59500 and pristinamycin against penicillin-resistant pneumococci.
The killing kinetics of two streptogramins, RP 59500 and pristinamycin against seventeen isolates of penicillin-susceptible and resistant pneumococci were studied. The antibiotics were tested at 1x, 2x and 4x the MIC for each individual isolate. The results showed a very good and rapid bactericidal activity within 1 hour for concentrations equal or greater to the MIC. These antibiotics are very promising agents for the treatment of infections due to multiresistant pneumococci.
Barakett
V
V
CHU Saint-Antoine, Laboratoire de Bactériologie-Virologie, Paris, France.
Lesage
D
D
Delisle
F
F
Richard
G
G
Petit
J C
JC
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D018432:Drug Resistance, Multiple; D066298:In Vitro Techniques; D007700:Kinetics; D008826:Microbial Sensitivity Tests; D010403:Penicillin Resistance; D013296:Streptococcus pneumoniae / Q000187:drug effects*; D014769:Virginiamycin / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D014769:Virginiamycin; C062940:quinupristin-dalfopristin