title: Increased apoptosis rate by hyperthermochemoradiotherapy for advanced rectal cancers.
abstract: Apoptosis induced in cancer cells by ionizing radiation, hyperthermia, and 5-fluorouracil (5-FU), termed "hyperthermochemoradiotherapy" (HCR), has been well studied in vitro; however, the role of apoptosis in the tumocidal effect of HCR for primary rectal cancers has not yet been clarified. Therefore, we examined the relationship between the therapeutic effect and induction rate of histological apoptosis in 16 patients with rectal cancers after HCR. Numerous Tunel-positive apoptotic cells were found in the tumor tissue after HCR, but few were found in the tumors which had not received HCR. The histological therapeutic effect was closely correlated to the rate of apoptosis. Thus, we suggest that HCR induces a therapeutic effect mainly through apoptosis in human rectal cancers.
authors.affiliation: First Department of Surgery, Kyoto Prefectural University of Medicine, Japan.
authors.forename: C
authors.initials: C
authors.lastname: Sakakura
authors.forename: K
authors.initials: K
authors.lastname: Koide
authors.forename: M
authors.initials: M
authors.lastname: Shirasu
authors.forename: D
authors.initials: D
authors.lastname: Ichikawa
authors.forename: M
authors.initials: M
authors.lastname: Wakasa
authors.forename: M
authors.initials: M
authors.lastname: Ogaki
authors.forename: J
authors.initials: J
authors.lastname: Yamazaki
authors.forename: J
authors.initials: J
authors.lastname: Inazawa
authors.forename: T
authors.initials: T
authors.lastname: Abe
authors.forename: H
authors.initials: H
authors.lastname: Taniguchi
authors.forename: A
authors.initials: A
authors.lastname: Hagiwara
authors.forename: T
authors.initials: T
authors.lastname: Yamaguchi
authors.forename: T
authors.initials: T
authors.lastname: Takahashi
mesh_terms: D000285:Administration, Rectal; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage / Q000627:therapeutic use*; D017209:Apoptosis / Q000502:physiology; D017024:Chemotherapy, Adjuvant; D005472:Fluorouracil / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D006979:Hyperthermia, Induced; D011446:Prospective Studies; D018714:Radiotherapy, Adjuvant; D012004:Rectal Neoplasms / Q000473:pathology / Q000503:physiopathology* / Q000601:surgery / Q000628:therapy*
chemical_list: D000964:Antimetabolites, Antineoplastic; D005472:Fluorouracil