[Ecto-ATPases and receptors for ATP].
Although enzymes which metabolize extracellular ATP (ecto-ATPases) have been described long ago, it has only recently become clear that such enzymes play an especially important role in cells possessing ATP receptors (P2-purinoceptors). In this review the authors characterize common features of ecto-ATPases, underlining the differences between these enzymes and other ATP-metabolizing enzymes. The authors also review their own recent studies dealing with the effects of various compounds on enzyme activity and on P2-purinoceptor-mediating responses. Since most known P2-purinoceptor antagonists inhibit ecto-ATPase activity, it is important to search for selective P2-purinoceptor antagonists as well as ecto-ATPase inhibitors.
Ziganshin
A U
AU
University College London, UK.
Ziganshina
L E
LE
Burnstok
D Zh
DZh
D000251:Adenosine Triphosphatases / Q000037:antagonists & inhibitors / Q000187:drug effects / Q000378:metabolism*; D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D001667:Binding, Competitive; D002118:Calcium / Q000378:metabolism; D002413:Cations, Divalent / Q000494:pharmacology; D002478:Cells, Cultured; D005109:Extracellular Matrix / Q000378:metabolism; D008274:Magnesium / Q000378:metabolism; D009130:Muscle, Smooth / Q000166:cytology / Q000187:drug effects / Q000201:enzymology; D009865:Oocytes / Q000166:cytology / Q000201:enzymology; D058919:Purinergic P2 Receptor Antagonists; D018048:Receptors, Purinergic P2 / Q000378:metabolism* / Q000502:physiology; D014982:Xenopus laevis
D002413:Cations, Divalent; D058919:Purinergic P2 Receptor Antagonists; D018048:Receptors, Purinergic P2; D000255:Adenosine Triphosphate; D000251:Adenosine Triphosphatases; D008274:Magnesium; D002118:Calcium