[Influence of environmental and genetic factors on levels of testosterone, estradiol and somatotropic hormones in mountaineers of the Pamir].
A role of genetic and environmental factors in variabilities of the levels of testosterone, estradiol, and somatotropic hormones (STH) in mountaineers of the Pamirs and Kirghizes was examined in relation to the place of residence above sea level. Testosterone and estradiol levels reduced in males and females with the altitude of their permanent residence in the studied populations. The variability in testosterone levels diminished with the altitude of locality. Blood O group (ABO system) residents of plains and low-altitude mountain regions had lower concentrations of estradiol and testosterone. With increased environmental extremeness (at 3000 and 3640 m), there was no association between steroid hormones and ABO systems. Higher variabilities in estradiol concentrations were noted in The Pamirs women. The united group of The Pamirs women showed a statistically significant increase of growth hormones in individuals with TFC1-C2 phenotype. TFC1-C2 heterozygotes are largely characterized by increased levels of STH as compared to its concentrations in TFC1-C1 homozygotes.
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Medico-Genetic Scientific Center RAMN, Moscow.
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Anikeeva
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D000531:Altitude; D001789:Blood Group Antigens / Q000235:genetics*; D004777:Environment; D004958:Estradiol / Q000097:blood*; D005006:Ethnicity; D005260:Female; D013006:Growth Hormone / Q000097:blood*; D006801:Humans; D008297:Male; D012424:Rural Population; D013620:Tajikistan; D013739:Testosterone / Q000097:blood*
D001789:Blood Group Antigens; D013739:Testosterone; D004958:Estradiol; D013006:Growth Hormone