title: Comparison of ethacridine lactate and prostaglandin E2 in second trimester medical abortion.
abstract: BACKGROUND
  A comparison of ethacridine lactate and prostaglandin E2 (PGE2) with or without oxytocin infusion in second trimester medical abortion cases.
  
  
  METHODS
  A prospective study was performed on 151 women requiring second trimester medical abortions between 1989 and 1995. Patients were randomly assigned to PGE2 group (n = 30), ethacridine lactate group (n = 48), ethacridine lactate combined with oxytocin infusion group (n = 49) and PGE2 combined with oxytocin infusion group (n = 24). Rates of successful abortion (i.e., complete evacuation of fetal and placental tissues from the uterus) within 24 hours for each group were determined and compared by chi2 and the Student t-test.
  
  
  RESULTS
  Statistically significant difference concerning successful abortion rates was observed between ethacridine lactate and PGE2 groups, PGE2 and PGE2+oxytocin infusion groups, and ethacridine lactate+oxytocin infusion and PGE2 groups, while there was no significant difference between ethacridine lactate and ethacridine lactate+oxytocin infusion groups, ethacridine lactate and PGE2+oxytocin infusion groups, and PGE2+oxytocin infusion and ethacridine lactate+oxytocin infusion groups.
  
  
  CONCLUSIONS
  Extra-amniotic ethacridine lactate instillation alone and intracervical PGE2 gel application are effective and safe methods for second trimester abortion.
authors.affiliation: Department of Obstetrics and Gynecology, Ministry of Health, Ankara State Hospital, Turkey.
authors.forename: I
authors.initials: I
authors.lastname: Inan
authors.forename: S
authors.initials: S
authors.lastname: Kelekçi
authors.forename: D
authors.initials: D
authors.lastname: Yazar
mesh_terms: D000028:Abortion, Induced; D000328:Adult; D015232:Dinoprostone / Q000008:administration & dosage*; D004975:Ethacridine / Q000008:administration & dosage*; D005260:Female; D005865:Gestational Age; D006801:Humans; D008423:Maternal Age; D010121:Oxytocin / Q000008:administration & dosage; D010298:Parity; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D011446:Prospective Studies
chemical_list: D010121:Oxytocin; D015232:Dinoprostone; D004975:Ethacridine