Alleles of the spontaneously hypertensive rat decrease blood pressure at loci on chromosomes 4 and 13.
In this study the spontaneously hypertensive rat (SHR/Mol) and the spontaneously diabetic BB/OK rat were crossed, and the F1 hybrids were backcrossed onto the BB/OK rat in order to search for cosegregation between blood pressure and loci on chromosomes 4 and 13. Cosegregation of microsatellites on chromosomes 4 (Spr, Npy, D4mit6, Il-6) and 13 (Atp1a2, D13Mit1, D13Uwm1) with blood pressure was evaluated using one-way analysis of variance. On chromosome 4 linkage of the Npy and D4Mit6 markers to systolic blood pressure was observed. A blood pressure QTL was also found on chromosome 13 within the renin locus. Surprisingly, alleles of the SHR strain at loci showing linkage to blood pressure on chromosome 4 and 13 promote lower blood pressure than the same alleles from the BB/OK strain. The transfer of D4Mit6 and renin locus from the SHR rat onto the genetic background of BB/OK rat will probably not lead to a model of diabetic hypertension, but the thorough characterisation of such congenics could contribute to the explanation of genetics and pathophysiology of hypertension in the SHR rat.
Kovács
P
P
Institute of Pathophysiology, University of Greifswald, Karlsburg, 17495, Germany.
Voigt
B
B
Klöting
I
I
D000483:Alleles; D000818:Animals; D001794:Blood Pressure / Q000235:genetics*; D002874:Chromosome Mapping; D002875:Chromosomes; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics / Q000503:physiopathology*; D005260:Female; D008040:Genetic Linkage; D006973:Hypertension / Q000235:genetics*; D008297:Male; D051381:Rats; D011913:Rats, Inbred BB; D011918:Rats, Inbred SHR