Peptide-MHC complexes assembled following multiple pathways: an opportunity for the design of vaccines and therapeutic molecules.
Antigen degradation and peptide loading to major histocompatibility complex class I and class II molecules are described with special emphasis on "noncanonical" pathways. Examples of specific peptide loading for measles proteins are provided. In addition, characterization of defined epitopes presented to T cells can lead to the design of products of special interest in medicine and, in particular, in development of vaccines.
Corradin
G
G
Institute of Biochemistry, University of Lausanne, Epalinges, Switzerland.
Demotz
S
S
D017951:Antigen Presentation; D000941:Antigens / Q000276:immunology / Q000378:metabolism; D000939:Epitopes / Q000276:immunology; D015395:Histocompatibility Antigens Class I / Q000276:immunology; D000949:Histocompatibility Antigens Class II / Q000276:immunology; D006801:Humans; D008285:Major Histocompatibility Complex / Q000276:immunology*; D008459:Measles virus / Q000276:immunology; D018448:Models, Immunological; D010455:Peptides / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology; D014612:Vaccines / Q000276:immunology; D014764:Viral Proteins / Q000276:immunology
D000941:Antigens; D000939:Epitopes; D015395:Histocompatibility Antigens Class I; D000949:Histocompatibility Antigens Class II; D010455:Peptides; D014612:Vaccines; D014764:Viral Proteins