Oncogenic changes in murine lymphoid tumors induced by in utero exposure to ionizing radiation.
We have investigated the oncogenic alterations in murine lymphomas induced by in utero exposure to gamma-radiation. The expression of the myc oncogene increased in 23% of the tumors. Alterations in the expression of the ras oncogenes and in the p53 tumor suppressor gene were not characteristic. The p53 gene was mutated in a low percentage of the tumors (12%). Ras mutations were not detected. Loss of heterozygosity (LOH) at the p53 locus was found in 30% of the tumors, and LOH at the mts tumor suppressor gene was detected in 23% of lymphomas. Multiple oncogenic changes were infrequent in the investigated tumors. There were no essential differences in the frequency of carcinogenic alterations in spontaneous and gamma-radiation-induced lymphomas.
Lumniczky
K
K
Department of Molecular Radiobiology, National Research Institute for Radiobiology and Radiobygiene, Budapest, Hungary.
Antal
S
S
Unger
E
E
Hidvégi
E J
EJ
Sáfrány
G
G
D000818:Animals; D003062:Codon / Q000235:genetics / Q000528:radiation effects; D005091:Exons / Q000235:genetics / Q000528:radiation effects; D005260:Female; D005720:Gamma Rays; D017353:Gene Deletion; D015972:Gene Expression Regulation, Neoplastic; D016147:Genes, Tumor Suppressor / Q000528:radiation effects; D016259:Genes, myc / Q000528:radiation effects; D016158:Genes, p53 / Q000528:radiation effects; D011905:Genes, ras / Q000528:radiation effects; D006579:Heterozygote; D008223:Lymphoma / Q000209:etiology / Q000235:genetics*; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D009154:Mutation / Q000235:genetics; D009381:Neoplasms, Radiation-Induced / Q000209:etiology / Q000235:genetics*; D009857:Oncogenes / Q000528:radiation effects*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D012334:RNA, Neoplasm / Q000235:genetics / Q000528:radiation effects
D003062:Codon; D012334:RNA, Neoplasm