Multiple roles for integrins during development.
Interactions between cells and extracellular matrix play a crucial role during development by controlling tissue remodelling and cell migration. Integrins are the main family of cell surface receptors for extracellular matrix. The knockout of integrin genes in mouse embryos has provided new insights into the function of these receptors during embryonic development and morphogenesis. The lethality observed either during embryonic life or after birth suggests that many integrins are essential.
Beauvais-Jouneau
A
A
UMR 144, CNRS-Institut Curie, Research Division, Paris, France.
Thiery
J P
JP
D000818:Animals; D005314:Embryonic and Fetal Development / Q000502:physiology*; D018507:Gene Expression Regulation, Developmental; D016023:Integrins / Q000235:genetics*; D051379:Mice; D018345:Mice, Knockout
D016023:Integrins