Elevated levels of circulating soluble adhesion molecules in peripheral blood of patients with unstable angina.
We have demonstrated increased levels of the circulating soluble adhesion molecules (sCAMs), ICAM-1, VCAM-1, and E-selectin in patients with unstable angina compared with healthy controls. Our findings support the role of inflammation in clinically unstable coronary disease, and may indicate a potential role for measurement of peripheral sICAM levels as a marker for inflammatory activity in atherosclerotic plaque.
Ghaisas
N K
NK
Department of Cardiology, St. James's Hospital, Dublin, Republic of Ireland.
Shahi
C N
CN
Foley
B
B
Goggins
M
M
Crean
P
P
Kelly
A
A
Kelleher
D
D
Walsh
M
M
D000328:Adult; D000787:Angina Pectoris / Q000097:blood; D000789:Angina, Unstable / Q000097:blood*; D002637:Chest Pain / Q000097:blood; D003324:Coronary Artery Disease / Q000097:blood; D019040:E-Selectin / Q000097:blood*; D005260:Female; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D019010:Vascular Cell Adhesion Molecule-1 / Q000097:blood*
D019040:E-Selectin; D019010:Vascular Cell Adhesion Molecule-1; D018799:Intercellular Adhesion Molecule-1