title: Segmentation of acoustic neuromas with magnetic resonance imaging and Eigen image filtering.
abstract: OBJECTIVE
  This study aimed to determine whether magnetic resonance imaging with Eigen image filtering can segment acoustic neuromas as a preliminary requirement to the development and validation of a volumetric method of measuring tumor size and growth using Eigen image filtering.
  
  
  METHODS
  This was an observational study.
  
  
  METHODS
  The study was performed in an academic, comprehensive multi-specialty group practice.
  
  
  METHODS
  Patients were a convenience sample of adults of both sexes who had acoustic neuromas identified by magnetic resonance imaging. Tumors ranged widely in size.
  
  
  METHODS
  Magnetic resonance imaging with digital image analysis using Eigen image filtering was the intervention.
  
  
  METHODS
  Observation and analysis of magnetic resonance images was the main outcome measure.
  
  
  RESULTS
  The ability of magnetic resonance imaging with Eigen image filtering to segment acoustic neuromas of various sizes and shapes is illustrated.
  
  
  CONCLUSIONS
  Magnetic resonance imaging with digital image analysis using Eigen image filtering is a promising method for volumetric measurement of acoustic neuroma size and growth. The potential for acoustic neuromas to grow may be underestimated by linear methods because of their relative lack of precision and of the geometric error that occurs in representing the volumetric growth of a three-dimensional tumor as a linear diameter.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Henry Ford Hospital, Detroit, Michigan, USA.
authors.forename: E M
authors.initials: EM
authors.lastname: Monsell
authors.forename: D D
authors.initials: DD
authors.lastname: Cody
authors.forename: E
authors.initials: E
authors.lastname: Spickler
authors.forename: J P
authors.initials: JP
authors.lastname: Windham
mesh_terms: D000328:Adult; D002530:Cerebellopontine Angle / Q000473:pathology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009464:Neuroma, Acoustic / Q000473:pathology*; D000159:Vestibulocochlear Nerve / Q000473:pathology*