title: [The participation of neutrophilic mechanisms in the pathogenesis of chronic elevated blood immune complexes].
abstract: For reproduction of chronic hyperimmunocomplexemia model the classic Cochrane C. G., 1973 elaboration was used. The circulating immune complexes (CIC) were identified by precipitation methods, and fixated--by immunofluorescent in endothelium reproduction of aorta, and their clearance organs--liver and spleen. The estimation of neutrophil status was carried out according to rosette-forming neutrophils ability--by latex, zimosane, mieloperoxidasa, NST tests. The growth of large and middle CIC in vessel bed was estimated, their fixation in aorta bifurcation, and also on liver and spleen calls, but their intensivity is less, comparing to aorta endothelium. The neutrophil status was characterised by O-neutrophils growth, strengthening of capturing macrophages function, considerable activation of fermentative polynuclear systems, although reserve possibilities in them grew in less degree. Morphologic investigations allow to speak mediatingly about neutrophils participation in endotheliocytes damage, and also about their ability to secure the mononuclear cells further participation in damaging of aorta walls and partially of liver and spleen.
authors.forename: M M
authors.initials: MM
authors.lastname: Bidiuk
authors.forename: V V
authors.initials: VV
authors.lastname: Chop'iak
authors.forename: L A
authors.initials: LA
authors.lastname: Liubinets'
authors.forename: S I
authors.initials: SI
authors.lastname: Pavlovich
authors.forename: H P
authors.initials: HP
authors.lastname: Nykytiuk
authors.forename: Z S
authors.initials: ZS
authors.lastname: Porokhovs'ka
mesh_terms: D000818:Animals; D000936:Antigen-Antibody Complex / Q000097:blood*; D001011:Aorta / Q000276:immunology / Q000473:pathology; D002448:Cell Adhesion; D002908:Chronic Disease; D004195:Disease Models, Animal; D007105:Immune Complex Diseases / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D008099:Liver / Q000276:immunology / Q000473:pathology; D008297:Male; D009504:Neutrophils / Q000201:enzymology / Q000276:immunology*; D010587:Phagocytosis; D051381:Rats; D013154:Spleen / Q000276:immunology / Q000473:pathology
chemical_list: D000936:Antigen-Antibody Complex