Inhibition of clastogenic effects of arsenic through continued oral administration of garlic extract in mice in vivo.
Crude aqueous extract of garlic bulbs (Allium sativum L. single clove variety) was administered by gavage to mice of both sexes daily for up to 30 and 60 days, in doses corresponding to 6 g for a 60 kg human body. Sodium arsenite (at 1/50 of LD50 dose) was injected subcutaneously to mice on every 7th day of the experiment. Chromosome preparations made from bone marrow following flame drying Giemsa schedule were screened for chromosomal aberrations. The clastogenic affects of prolonged exposure to sodium arsenite --a strong clastogen-- was reduced by a highly significant amount when crude garlic extract, in the dose used, was given daily to the mice by intubation for the same period.
Choudhury
A R
AR
Centre for Advanced Study in Cell and Chromosome Research, Department of Botany, University of Calcutta, India.
Das
T
T
Sharma
A
A
Talukder
G
G
D000284:Administration, Oral; D000818:Animals; D016587:Antimutagenic Agents / Q000494:pharmacology*; D018053:Arsenites / Q000633:toxicity*; D001399:Azure Stains; D001854:Bone Marrow Cells; D002869:Chromosome Aberrations; D005260:Female; D005737:Garlic; D007621:Karyotyping; D008297:Male; D051379:Mice; D016685:Mitomycin / Q000494:pharmacology; D009153:Mutagens / Q000633:toxicity*; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology; D010946:Plants, Medicinal; D017670:Sodium Compounds / Q000633:toxicity*
D016587:Antimutagenic Agents; D018053:Arsenites; D001399:Azure Stains; D009153:Mutagens; D010936:Plant Extracts; D017670:Sodium Compounds; C017947:sodium arsenite; D016685:Mitomycin