title: Role of inflammation in the pathogenesis of unstable coronary artery disease.
abstract: In this article, the clinical, angiographic, and postmortem features of unstable angina are reviewed and its pathogenesis is discussed. Coronary plaque inflammation may play a key role in the pathogenesis of unstable angina and the evidence for this assertion is examined. Finally, the therapeutic implications of the involvement of inflammation in acute coronary syndromes are outlined.
authors.affiliation: Istituto di Cardiologia, Universita' Cattolica del Sacro Cuore, Rome, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Crea
authors.forename: L M
authors.initials: LM
authors.lastname: Biasucci
authors.forename: A
authors.initials: A
authors.lastname: Buffon
authors.forename: G
authors.initials: G
authors.lastname: Liuzzo
authors.forename: C
authors.initials: C
authors.lastname: Monaco
authors.forename: G
authors.initials: G
authors.lastname: Caligiuri
authors.forename: A
authors.initials: A
authors.lastname: Kol
authors.forename: G
authors.initials: G
authors.lastname: Sperti
authors.forename: D
authors.initials: D
authors.lastname: Cianflone
authors.forename: A
authors.initials: A
authors.lastname: Maseri
mesh_terms: D000789:Angina, Unstable / Q000276:immunology* / Q000503:physiopathology; D000818:Animals; D017023:Coronary Angiography; D016207:Cytokines / Q000502:physiology; D004730:Endothelium, Vascular / Q000502:physiology; D006331:Heart Diseases / Q000503:physiopathology; D006801:Humans; D007249:Inflammation / Q000503:physiopathology; D013927:Thrombosis / Q000503:physiopathology
chemical_list: D016207:Cytokines