[The effect of intravenous amino acids in total parenteral nutrition on the healing of experimental colonic anastomoses in the rat].
The authors present a study in two groups of Wistar rats, which were given two different parenteral nutritions with two different amounts of proteins, during different periods of time (4, 7 and 11 days), with the objective of evaluating their influence on the healing of a colonic anastomosis which was performed prior to the initiation of the TPN. To asses the condition of the colonic anastomosis, we studied the rupture pressure of the colon containing the anastomosis, the hydroxyproline concentration of said anastomosis, and the histological study of the same. The results indicate that the group of animals which were fed with a hyperproteinic diet during a longer period of time, showed a better degree of healing than the rest of the study groups.
Vázquez Prado
A
A
Centro de Investigación, Hospital General Universitario de Valencia, España.
Aznar Vicente
J J
JJ
Villalba Ferrer
F
F
Marti Bonmati
E
E
Perkins Wineberger
I
I
García Coret
M J
MJ
Artigues Sánchez de Rojas
E
E
Fuster Diana
C
C
Montalvá Orón
E
E
D000596:Amino Acids / Q000008:administration & dosage*; D000704:Analysis of Variance; D000714:Anastomosis, Surgical; D000818:Animals; D003106:Colon / Q000378:metabolism / Q000473:pathology / Q000601:surgery*; D006909:Hydroxyproline / Q000378:metabolism; D007262:Infusions, Intravenous; D008297:Male; D010289:Parenteral Nutrition, Total / Q000379:methods* / Q000706:statistics & numerical data; D051381:Rats; D017208:Rats, Wistar; D014945:Wound Healing / Q000187:drug effects*
D000596:Amino Acids; D006909:Hydroxyproline