Electrophysiological studies of the cell membrane of bullfrog sympathetic neurons.
Active and passive properties of dissociated bullfrog sympathetic ganglion cells were examined in the whole-cell configuration. Electrical constants were 107 k omega cm2 and 1 microFcm2 for the unitary cell membrane area. Under conditions in which the equilibrium potential was 55 mV for sodium ions and -101 mV for potassium ions, the action potential and its after-hyperpolarization peaked at 50 and -83 mV, respectively, when elicited from the resting potential of -63 mV. These observations are consistent with those reported previously for other autonomic neurons. The reversal potential of the after-hyperpolarization was approximately 10 mV less negative than the potassium equilibrium potential. The basis of this difference has been discussed using a hypothetical equivalent circuit.
Tokimasa
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Department of Physiology, School of Medicine, Tokai University, Isehara Kanagawa, Japan.
D000200:Action Potentials / Q000502:physiology; D000818:Animals; D002462:Cell Membrane / Q000502:physiology; D004594:Electrophysiology; D005728:Ganglia, Sympathetic / Q000166:cytology / Q000502:physiology*; D008564:Membrane Potentials / Q000502:physiology; D009474:Neurons / Q000166:cytology / Q000502:physiology*; D011892:Rana catesbeiana / Q000502:physiology*