Central neurocytoma: one associated with a fourth ventricular PNET/medulloblastoma and the second mixed with adipose tissue.
We report two cases of central neurocytoma; one located in the right lateral ventricle and associated with a distinctly separate primitive neuroectodermal tumor (PNET)/medulloblastoma of the fourth ventricle, and the other admixed with fat cells and arising from the left lateral and third ventricles with extension into the corpus callosum. We discuss that concurrent occurrences of PNET and adipose tissue are not fortuitous events, but an evidence that neurocytomas and PNETs originate in the residual germinal pool from common progenitor cell rests recapitulating features of developing neurons and with a potential for mesenchymal differentiation.
Horoupian
D S
DS
Department of Pathology (Neuropathology), Stanford University, CA 94305, USA.
Shuster
D L
DL
Kaarsoo-Herrick
M
M
Shuer
L M
LM
D000273:Adipose Tissue / Q000473:pathology*; D000328:Adult; D001932:Brain Neoplasms / Q000737:chemistry / Q000473:pathology*; D002552:Cerebral Ventricles / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging; D008297:Male; D008527:Medulloblastoma / Q000737:chemistry / Q000473:pathology*; D018306:Neurocytoma / Q000737:chemistry / Q000473:pathology*; D018242:Neuroectodermal Tumors, Primitive / Q000737:chemistry / Q000473:pathology*; D016708:Synaptophysin / Q000032:analysis; D014057:Tomography, X-Ray Computed
D016708:Synaptophysin