title: The conservative management of Paget's disease of the breast with radiotherapy.
abstract: BACKGROUND
  The purpose of this study was to evaluate the feasibility of breast-conserving therapy involving limited surgery and definitive radiotherapy as a treatment for Paget's disease, and to determine the disease free and overall survival associated with this approach.
  
  
  METHODS
  The authors retrospectively reviewed the charts of all patients treated during the period 1980-1994 for Paget's disease of the breast who did not present with a palpable mass or mammographic density. Through a collaborative review, 30 cases were identified. A biopsy confirming the presence of typical Paget's cells was performed on all patients. All patients received external beam radiotherapy to the breast, with a median dose of 50 gray (Gy). Ninety-seven percent received a boost to the remaining nipple or tumor bed, with a median dose to the tumor bed of 61.5 Gy.
  
  
  RESULTS
  The median follow-up for surviving patients was 62 months. Three patients (10%) developed a recurrence in the breast as the only site of first failure, and 2 additional patients (7%) experienced failure in the breast as a component of first failure. The median time to local failure was 69 months. The 5- and 8-year actuarial estimates of local failure as the only site of first failure were 9% (95% confidence interval [CI], 0-20%) and 16% (95% CI, 0-31%), respectively. Of the 5 patients with local failures, 3 were among 22 patients (14%) who underwent complete resection of the nipple or nipple-areola complex, compared with 2 failures among 6 patients (33%) after partial resection (P = 0.29). There were no failures among 2 patients who had a biopsy only. Four of 5 local failures were salvaged by mastectomy, and 3 of these patients were free of disease after a median follow-up of 52 months. The 5- and 8-year estimates of disease free survival for the overall series were both 95% (95% CI, 87-100%); cause specific overall survival was 100% at 8 years.
  
  
  CONCLUSIONS
  Breast-conserving therapy involving complete resection of the nipple-areola complex followed by definitive radiotherapy is a viable alternative to mastectomy in the treatment of Paget's disease. High rates of disease free and cause specific survival, in addition to adequate local control, justify consideration of a conservative approach.
authors.affiliation: Department of Radiation Oncology, University of Michigan School of Medicine, Ann Arbor 48109, USA.
authors.forename: L J
authors.initials: LJ
authors.lastname: Pierce
authors.forename: B G
authors.initials: BG
authors.lastname: Haffty
authors.forename: L J
authors.initials: LJ
authors.lastname: Solin
authors.forename: B
authors.initials: B
authors.lastname: McCormick
authors.forename: F A
authors.initials: FA
authors.lastname: Vicini
authors.forename: D E
authors.initials: DE
authors.lastname: Wazer
authors.forename: A
authors.initials: A
authors.lastname: Recht
authors.forename: M
authors.initials: M
authors.lastname: Strawderman
authors.forename: A S
authors.initials: AS
authors.lastname: Lichter
mesh_terms: D000328:Adult; D000368:Aged; D018572:Disease-Free Survival; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D010144:Paget's Disease, Mammary / Q000532:radiotherapy* / Q000601:surgery; D011879:Radiotherapy Dosage; D018714:Radiotherapy, Adjuvant; D012189:Retrospective Studies; D016019:Survival Analysis; D016896:Treatment Outcome