title: Bioactive polymers 53: synthesis of poly(vinyl alcohol) and nalidixic acid based pro-drugs.
abstract: The present paper studies the process of esterification of nalidixic acid on poly(vinyl alcohol). The influence of time, dilution and concentration of the reactants on the efficiency of esterification with dicyclohexylcarbodiimide has been followed. By experiment scheduling according to a centered, rotatory, compound, second order program, optimum conditions for the system under study have been found. On the other hand, the evolution of reaction of esterification of the nalidixic acid on poly(vinyl alcohol) was followed by using the activator-catalyst (4-pirolidinopyridine) system. An increase of the esterification yield up to 37% has been observed.
authors.affiliation: University of Sherbrooke, Department of Chemical Engineering, Quebec, Canada.
authors.forename: S
authors.initials: S
authors.lastname: Dumitriu
authors.forename: V
authors.initials: V
authors.lastname: Blascu
mesh_terms: D001672:Biocompatible Materials; D001704:Biopolymers / Q000737:chemistry; D004951:Esterification; D009268:Nalidixic Acid / Q000737:chemistry*; D011142:Polyvinyl Alcohol / Q000737:chemistry*; D011355:Prodrugs / Q000138:chemical synthesis*; D013057:Spectrum Analysis
chemical_list: D001672:Biocompatible Materials; D001704:Biopolymers; D011355:Prodrugs; D009268:Nalidixic Acid; D011142:Polyvinyl Alcohol