title: Evaluation of the gastroprotective effect of Laurus nobilis seeds on ethanol induced gastric ulcer in rats.
abstract: The possible antiulcerogenic activity of Laurus nobilis seeds was tested on experimentally (ethanol) induced gastric ulcer in rats. The results indicated antiulcerogenic activity for 20 and 40% aqueous extracts as well as for the oily fraction of these seeds. In acute toxicity studies, the aqueous extract was found safe with LD50 compared to oil LD50 0.33 ml/kg body weight.
authors.affiliation: Faculty of Pharmacy, University of Jordan, Amman.
authors.forename: F U
authors.initials: FU
authors.lastname: Afifi
authors.forename: E
authors.initials: E
authors.lastname: Khalil
authors.forename: S O
authors.initials: SO
authors.lastname: Tamimi
authors.forename: A
authors.initials: A
authors.lastname: Disi
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D004195:Disease Models, Animal; D000431:Ethanol / Q000008:administration & dosage; D005260:Female; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D009821:Oils / Q000737:chemistry; D010936:Plant Extracts / Q000627:therapeutic use* / Q000633:toxicity; D051381:Rats; D012639:Seeds; D013276:Stomach Ulcer / Q000139:chemically induced / Q000188:drug therapy*
chemical_list: D000897:Anti-Ulcer Agents; D009821:Oils; D010936:Plant Extracts; D000431:Ethanol