title: ["Multicore" myopathy: report of 5 cases].
abstract: Five cases (three of them from a same family) of multicore myopathy are presented. The age at diagnosis ranged from 4 to 38 years. In 2 cases muscle complaints developed early in childhood while in the remaining 3 cases raised CK serum levels lead to perform a muscle biopsy. Malignant hyperthermia occurred in a young boy among the three affected relatives. Other family members are probably affected, suggesting an autosomal dominant inheritance. In none of the patients progressive disabling myopathy has occurred after a long term follow-up. A review of the bibliography is included, and clinical and evolutive characteristics of this myopathy are commented.
authors.affiliation: Grup d'Investigació Muscular, Servei de Medicina Interna, Hospital Clínic i Provincial, Universitat de Barcelona.
authors.forename: O
authors.initials: O
authors.lastname: Miró
authors.forename: M
authors.initials: M
authors.lastname: Cebrián
authors.forename: M
authors.initials: M
authors.lastname: Laguno
authors.forename: E
authors.initials: E
authors.lastname: Pedrol
authors.forename: J
authors.initials: J
authors.lastname: Casademont
authors.forename: J M
authors.initials: JM
authors.lastname: Grau
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D009135:Muscular Diseases / Q000235:genetics* / Q000473:pathology*; D010375:Pedigree; D012189:Retrospective Studies