[Morphologic effect of adrenaline and insulin on bone capillaries after receptor blockade. Functional transmission electron microscopy analysis].
In three groups of six mice each, the alpha- and beta-receptors were blocked by phentolamine and propranolol. The mice in the three groups then received an intravenous bolus injection of saline solution, epinephrine, and insulin, respectively. Cortical bone capillaries from the tibia diaphysis were submitted to transmission electron microscopy (TEM). The lumen and endothelium were measured and the results compared. Significant changes were only noted in the endothelium after the administration of insulin. These findings suggest that there are also insulin receptors in bone. Furthermore, they support previous findings in similar studies with epinephrine.
Döhler
J R
JR
I. Chirurgische Abteilung-Orthopädie und Unfallchirurgie, Krankenhaus Plau am See.
Hughes
S P
SP
D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology*; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000818:Animals; D001842:Bone and Bones / Q000098:blood supply*; D002200:Capillary Resistance / Q000187:drug effects* / Q000502:physiology; D004730:Endothelium, Vascular / Q000187:drug effects; D004837:Epinephrine / Q000494:pharmacology*; D005260:Female; D007328:Insulin / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008854:Microscopy, Electron; D010646:Phentolamine / Q000494:pharmacology*; D011433:Propranolol / Q000494:pharmacology*; D011972:Receptor, Insulin / Q000187:drug effects*; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects*; D011943:Receptors, Adrenergic, beta / Q000187:drug effects*
D000317:Adrenergic alpha-Antagonists; D000319:Adrenergic beta-Antagonists; D007328:Insulin; D011942:Receptors, Adrenergic, alpha; D011943:Receptors, Adrenergic, beta; D011433:Propranolol; D011972:Receptor, Insulin; D004837:Epinephrine; D010646:Phentolamine