title: Synthesis and bone resorption effect of alkoxy-substituted xanthones.
abstract: A topological modification of ipriflavone 1, a recent antiosteoporotic drug, is described. The flavone moiety of 1 has been replaced by a xanthone one. Among the new derivatives, the 3,6-diisopropoxyxanthone (2a) has shown significant bone resorption inhibition in in vitro and in vivo tests.
authors.affiliation: Institute of Pharmaceutical Chemistry, University of Milan, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Pifferi
authors.forename: P
authors.initials: P
authors.lastname: Da Re
authors.forename: P
authors.initials: P
authors.lastname: Valenti
authors.forename: A
authors.initials: A
authors.lastname: Bisi
authors.forename: S
authors.initials: S
authors.lastname: Malandrino
mesh_terms: D000818:Animals; D001862:Bone Resorption / Q000188:drug therapy*; D006801:Humans; D051381:Rats; D014966:Xanthenes / Q000138:chemical synthesis* / Q000494:pharmacology*; D044004:Xanthones
chemical_list: D014966:Xanthenes; D044004:Xanthones; C009689:xanthone