title: Childhood adversity and adult psychiatric disorder in the US National Comorbidity Survey.
abstract: BACKGROUND
  Survey data are presented on the associations between retrospectively reported childhood adversities and subsequent onset and persistence of DSM-III-R disorders.
  
  
  METHODS
  Data come from the US National Comorbidity Survey, a large survey of the US household population.
  
  
  RESULTS
  Twenty-six adversities were considered, including loss events (e.g. parental divorce), parental psychopathologies (e.g. maternal depression), interpersonal traumas (e.g. rape) and other adversities (e.g. natural disaster). These adversities were consistently associated with onset, but not persistence, of DSM-III-R mood disorders, anxiety disorders, addictive disorders and acting out disorders. Most bivariate associations with onset attenuated in models that controlled for clustering of adversities and for lifetime co-morbidities among psychiatric disorders. Multivariate effects of adversities in logistic models were additive, which means that they have multiplicative effects on probability of disorder onset. Adversities showed little specificity. An analysis of time decay showed that the effects of childhood adversities on disorder onset persist beyond childhood.
  
  
  CONCLUSIONS
  The existence of strong clustering among childhood adversities and lifetime co-morbidity among adult disorders means that caution is needed in interpreting the results of previous single-adversity single-disorder studies as documenting unique effects of specific childhood adversities on specific adult disorders. Future studies need to assess a broader range of adversities and disorders and to explore the existence and effects of commonly occurring adversity clusters. Replication is needed to verify that the effects of childhood adversities are mostly on first onset rather than on the creation of vulnerabilities that lead to increased risk of persistence.
authors.affiliation: Department of Health Care Policy, Harvard Medical School, Boston, MA 02115, USA.
authors.forename: R C
authors.initials: RC
authors.lastname: Kessler
authors.forename: C G
authors.initials: CG
authors.lastname: Davis
authors.forename: K S
authors.initials: KS
authors.lastname: Kendler
mesh_terms: D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D001008:Anxiety Disorders / Q000453:epidemiology; D015984:Causality; D016009:Chi-Square Distribution; D002648:Child; D002668:Child Rearing; D016241:Child of Impaired Parents / Q000706:statistics & numerical data; D015897:Comorbidity; D016001:Confidence Intervals; D003430:Cross-Sectional Studies; D005192:Family Health; D005260:Female; D006306:Health Surveys; D006801:Humans; D008016:Life Change Events; D016013:Likelihood Functions; D016015:Logistic Models; D008297:Male; D001523:Mental Disorders / Q000453:epidemiology*; D008875:Middle Aged; D019964:Mood Disorders / Q000453:epidemiology; D016017:Odds Ratio; D015995:Prevalence; D012189:Retrospective Studies; D019966:Substance-Related Disorders / Q000453:epidemiology; D016019:Survival Analysis; D013997:Time Factors; D014481:United States / Q000453:epidemiology