title: Stachybotrin C and parvisporin, novel neuritogenic compounds. I. Taxonomy, isolation, physico-chemical and biological properties.
abstract: Stachybotrin C and parvisporin, novel neuritogenic compounds, were isolated from the culture broth of Stachybotrys parvispora F4708. Stachybotrin C induced significant neurite outgrowth in PC12 cells and showed cell survival activity in the primary culture of cerebral cortical neurons. Parvisporin demonstrated only weak neuritogenic activity.
authors.affiliation: Medicinal Research Laboratories, Taisho Pharmaceutical Co., Ltd., Saitama, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Nozawa
authors.forename: K
authors.initials: K
authors.lastname: Yamamoto
authors.forename: M
authors.initials: M
authors.lastname: Ito
authors.forename: N
authors.initials: N
authors.lastname: Sakai
authors.forename: K
authors.initials: K
authors.lastname: Mizoue
authors.forename: F
authors.initials: F
authors.lastname: Mizobe
authors.forename: K
authors.initials: K
authors.lastname: Hanada
mesh_terms: D000818:Animals; D001547:Benzaldehydes / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D001578:Benzopyrans / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D002540:Cerebral Cortex / Q000187:drug effects; D005233:Fatty Alcohols / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D005285:Fermentation; D007211:Indoles / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D009474:Neurons / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D013191:Stachybotrys
chemical_list: D001547:Benzaldehydes; D001578:Benzopyrans; D005233:Fatty Alcohols; D007211:Indoles; C108547:parvisporin; C108546:stachybotrin C