[TGF-beta and its receptors].
TGF-beta is a member of a superfamily associated with development and regulation of cell growth. Recently, its two receptors and intracellular components of signal transduction, a Smad family, have been identified. The type II receptor gene has been found to be mutated specifically in hereditary colon cancers, HNPCC. Alterations of the Smad 4 gene were also detected in pancreatic and colorectal cancers.
Yuasa
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Y
Dept. of Hygiene, Tokyo Medical and Dental University School of Medicine.
D003110:Colonic Neoplasms / Q000737:chemistry / Q000235:genetics; D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000209:etiology / Q000235:genetics; D006801:Humans; D018125:Receptors, Transforming Growth Factor beta / Q000737:chemistry / Q000502:physiology*; D015398:Signal Transduction; D016212:Transforming Growth Factor beta / Q000737:chemistry / Q000235:genetics / Q000502:physiology*
D018125:Receptors, Transforming Growth Factor beta; D016212:Transforming Growth Factor beta