title: The hemolysis test of the Gyro C1E3 pump in pulsatile mode.
abstract: While a centrifugal pump is generally used for nonpulsatile blood flow, it can also produce a pulsatile flow by alternating the impeller rotational speed (rpm) periodically. However, there is a concern that this centrifugal pump pulsatile mode may induce added hemolysis as a result of the repeated acceleration and deceleration of rpm. Thus, a hemolysis study of the pulsatile modes of the Gyro C1E3 centrifugal pump (Gyro-P) was conducted. The results were then compared with the nonpulsatile mode of the same pump (Gyro-N) and the nonpulsatile BioMedicus BP-80 (Bio-N) pump. Three different conditions were simulated: left ventricular assist device (LVAD), cardiopulmonary bypass (CPB), and percutaneous cardiopulmonary support (PCPS). The beating rate of the Gyro-P was set at 40 bpm, with repetition of two different impeller speed (the lower being 70% of the higher speed). The 2 impeller speeds were set to obtain the same average flow as that of the nonpulsatile mode. The hemolysis results of the Gyro-P were comparable to or better than those of Bio-N, and no excessive hemolysis was observed, compared to the Gyro-N. In conclusion, The Gyro-P had an excellent hemolytic characteristic and generated no excessive hemolysis in most clinical usage conditions. With the concern of hemolysis eliminated, this pulsatile mode may have various possible mode advantages.
authors.affiliation: Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA.
authors.forename: E
authors.initials: E
authors.lastname: Tayama
authors.forename: T
authors.initials: T
authors.lastname: Nakazawa
authors.forename: Y
authors.initials: Y
authors.lastname: Takami
authors.forename: K
authors.initials: K
authors.lastname: Makinouchi
authors.forename: S
authors.initials: S
authors.lastname: Ohtsubo
authors.forename: Y
authors.initials: Y
authors.lastname: Ohashi
authors.forename: A J
authors.initials: AJ
authors.lastname: Andrade
authors.forename: J
authors.initials: J
authors.lastname: Glueck
authors.forename: J
authors.initials: J
authors.lastname: Mueller
authors.forename: Y
authors.initials: Y
authors.lastname: Nosé
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001783:Blood Flow Velocity / Q000502:physiology; D002315:Cardiopulmonary Bypass / Q000009:adverse effects / Q000592:standards*; D002417:Cattle; D002498:Centrifugation; D006339:Heart Rate / Q000502:physiology; D006353:Heart-Assist Devices / Q000009:adverse effects* / Q000592:standards; D006454:Hemoglobins / Q000378:metabolism; D006461:Hemolysis; D008962:Models, Theoretical; D011673:Pulsatile Flow; D012044:Regression Analysis
chemical_list: D006454:Hemoglobins