Antinociception induced by verapamil and chloramphenicol in mice.
The analgesic effects of verapamil, a calcium channel blocker, and chloramphenicol, a phenicolated antibiotic, were compared using the test of acetic-acid-induced writhing and the hot-plate test in mice. The results suggest that both drugs have antinociceptive properties comparable to salicylate analgesia. No significant difference was found between verapamil- and chloramphenicol-induced analgesia (p < 0.05).
Yildiran
G
G
Department of Pharmacology and Toxicology, Faculty of Medicine, Kocaeli University, Derince-Izmit, Turkey.
Ulak
G
G
Utkan
T
T
Göldeli
E
E
Gacar
N
N
Erden
F
F
D000698:Analgesia / Q000379:methods*; D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D002701:Chloramphenicol / Q000494:pharmacology*; D005260:Female; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010147:Pain Measurement / Q000379:methods; D014700:Verapamil / Q000494:pharmacology*
D000700:Analgesics; D000900:Anti-Bacterial Agents; D002121:Calcium Channel Blockers; D002701:Chloramphenicol; D014700:Verapamil