Prolonged Uhthoff phenomenon in sarcoidosis.
OBJECTIVE
To report a patient with sarcoidosis of the anterior visual pathways in whom one of the primary symptoms was visual loss lasting 24 hours after exposure to heat.


METHODS
Case report and review of the literature.


RESULTS
The transient visual loss was exquisitely sensitive to intravenous corticosteroids and lasted longer than the typical Uhthoff phenomenon. Serum angiotensin-converting enzyme level was increased, chest x-ray showed hilar adenopathy, gallium scan disclosed bilateral intense tracer uptake in the hila, and transbronchial lung biopsy showed noncaseating granulomas with negative stains for fungi and mycobacteria, consistent with sarcoidosis.


CONCLUSIONS
Uhthoff phenomenon, typically associated with demyelinating optic neuritis, may occur in an atypical form in patients with sarcoidosis of the optic nerve.
Haupert
C L
CL
Department of Ophthalmology, Emory University School of Medicine, Atlanta, GA 30322, USA.
Newman
N J
NJ
D000328:Adult; D005260:Female; D006358:Hot Temperature / Q000009:adverse effects*; D006801:Humans; D008168:Lung / Q000473:pathology; D008279:Magnetic Resonance Imaging; D009901:Optic Nerve Diseases / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology; D012507:Sarcoidosis / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology*; D013997:Time Factors; D014786:Vision Disorders / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology