The rabbit ileum: a sensitive and selective preparation for the neuropeptide Y Y5 receptor.
The rabbit ileum shows high sensitivity to neuropeptide Y. Relaxations are obtained in this tissue with human pancreatic polypeptide > peptide YY > > [Leu31,Pro34]neuropeptide Y > rat pancreatic polypeptide > human neuropeptide Y in this order of potency that is indicative of a Y5 receptor. Effects of neuropeptide Y and congeners are not affected by neuropeptide Y Y1 receptor antagonist (BIBP 3226), but are reduced by the neuropeptide Y Y5 receptor antagonist JCF 104 (2-(naphtalen-1-yl)-3-phenylpropane-1,2-diamine). Rabbit ilea provide sensitive and selective neuropeptide Y Y5 receptor preparations.
Pheng
L H
LH
Department of Pharmacology, Medical School, Université de Sherbrooke, Québec, Canada.
Quirion
R
R
Iyengar
S
S
Fournier
A
A
Regoli
D
D
D000818:Animals; D019167:Appetite Stimulants / Q000494:pharmacology; D001120:Arginine / Q000031:analogs & derivatives / Q000494:pharmacology; D001667:Binding, Competitive; D003959:Diamines / Q000378:metabolism / Q000494:pharmacology; D006801:Humans; D007082:Ileum / Q000187:drug effects / Q000378:metabolism*; D009281:Naphthalenes / Q000378:metabolism / Q000494:pharmacology; D009478:Neuropeptide Y / Q000031:analogs & derivatives / Q000494:pharmacology; D010191:Pancreatic Polypeptide / Q000494:pharmacology; D019894:Peptide YY / Q000494:pharmacology; D011817:Rabbits; D051381:Rats; D017476:Receptors, Neuropeptide Y / Q000037:antagonists & inhibitors / Q000187:drug effects* / Q000378:metabolism; D013329:Structure-Activity Relationship
C109480:2-(naphthalen-1-yl)-3-phenylpropane-1,2-diamine; D019167:Appetite Stimulants; C092926:BIBP 3226; D003959:Diamines; D009281:Naphthalenes; D009478:Neuropeptide Y; D017476:Receptors, Neuropeptide Y; C100568:neuropeptide Y5 receptor; D019894:Peptide YY; C062259:neuropeptide Y, Leu(31)-Pro(34)-; D010191:Pancreatic Polypeptide; D001120:Arginine