title: Long-term results of growth hormone treatment in France in children of short stature: population, register based study.
abstract: OBJECTIVE
  To describe the growth of children treated with growth hormone and to evaluate the prognostic factors for height at the end of treatment.
  
  
  METHODS
  Register based cohort study.
  
  
  METHODS
  French national register of all children treated with growth hormone.
  
  
  METHODS
  3233 short stature children (3165 of whom were deficient in growth hormone) who were treated with growth hormone (excluding children with Turner's syndrome) and whose treatment started between 1973 and 1989, last data being recorded in December 1993.
  
  
  METHODS
  Annual changes in height, and height at the end of treatment.
  
  
  RESULTS
  Mean height SD score at the end of treatment, after a mean of 4.3 years, was -2, corresponding to gain in mean height SD score of 1 and to a height SD score of 1.1 below target height. In all, 923 children prematurely stopped taking growth hormone treatment, mainly because of insufficient response (insufficient growth) or tiredness. Variables that predicted height at the end of treatment were age, target height, aetiology of short stature, use of puberty inhibitors, and type of growth hormone.
  
  
  CONCLUSIONS
  The outcome of children of short stature with growth hormone deficiency who were treated with growth hormone has been less favourable than initially assumed. Growth hormone treatment has not restored normal growth to these children. The highly demanding nature and high costs of this treatment require an optimised prescription, and this remains to be determined.
authors.affiliation: Département de Biostatistique et d'Informatique Médicale (Faculté Cochin, Université Paris V) Hôpital Cochin, France. coste@cochin.univ-paris5.fr
authors.forename: J
authors.initials: J
authors.lastname: Coste
authors.forename: M
authors.initials: M
authors.lastname: Letrait
authors.forename: J C
authors.initials: JC
authors.lastname: Carel
authors.forename: J P
authors.initials: JP
authors.lastname: Tresca
authors.forename: P
authors.initials: P
authors.lastname: Chatelain
authors.forename: P
authors.initials: P
authors.lastname: Rochiccioli
authors.forename: J L
authors.initials: JL
authors.lastname: Chaussain
authors.forename: J C
authors.initials: JC
authors.lastname: Job
mesh_terms: D000293:Adolescent; D000365:Age Determination by Skeleton; D001827:Body Height / Q000187:drug effects*; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D005260:Female; D005544:Forecasting; D005602:France; D006130:Growth Disorders / Q000188:drug therapy* / Q000503:physiopathology; D013006:Growth Hormone / Q000627:therapeutic use*; D019382:Human Growth Hormone / Q000172:deficiency; D006801:Humans; D008297:Male; D016896:Treatment Outcome
chemical_list: D019382:Human Growth Hormone; D013006:Growth Hormone