Effect of demineralized bone matrix on bone growth within a porous HA material: a histologic and histometric study.
Coralline hydroxyapatite (cHA) is an osteoconductive material currently being used as a bone graft substitute. Created by the hydrothermal conversion of the calcium carbonate skeleton of coral to hydroxyapatite, this material has a porous structure similar to cancellous bone. Addition of demineralized bone matrix (DBM) would conceivably create a composite with both osteoconductive and osteoinductive properties. This pilot study evaluated the healing of rabbit cranial defects that had been filled with cHA or cHA augmented with a DBM gel formed by adding glycerol to the DBM particulate. Data from these were then compared to unfilled defects from a previous study. Results indicated enhancement of new bone formation and an increase in the rate of healing in the defects filled with the cHA-DBM gel composite. Further studies are warranted.
Damien
C J
CJ
Laboratories for Orthopaedic Research, UMDNJ-New Jersey Medical School, Newark, USA.
Parsons
J R
JR
Prewett
A B
AB
Huismans
F
F
Shors
E C
EC
Holmes
R E
RE
D000818:Animals; D018775:Bone Demineralization Technique; D001857:Bone Matrix / Q000648:ultrastructure*; D018786:Bone Substitutes; D002516:Ceramics; D017886:Durapatite; D008422:Materials Testing; D008854:Microscopy, Electron; D016348:Osseointegration; D019736:Prostheses and Implants; D011817:Rabbits; D011897:Random Allocation; D012886:Skull / Q000601:surgery; D013499:Surface Properties
D018786:Bone Substitutes; C082200:coralline sulfate; D017886:Durapatite