title: Testosterone-regulated expression of enzymes involved in steroid and aromatic hydrocarbon catabolism in Comamonas testosteroni.
abstract: The effect of testosterone as the sole carbon source on protein expression was analyzed in Comamonas testosteroni. Testosterone simultaneously induced the expression of steroid- and aromatic hydrocarbon-catabolizing enzymes and repressed one amino acid-degrading enzyme. It is suggested that steroids play a regulative role in catabolic enzyme synthesis during adaptive growth of C. testosteroni.
authors.affiliation: Department of Pharmacology and Toxicology, Philipps University, Marburg, Germany.
authors.forename: E
authors.initials: E
authors.lastname: Möbus
authors.forename: M
authors.initials: M
authors.lastname: Jahn
authors.forename: R
authors.initials: R
authors.lastname: Schmid
authors.forename: D
authors.initials: D
authors.lastname: Jahn
authors.forename: E
authors.initials: E
authors.lastname: Maser
mesh_terms: D000595:Amino Acid Sequence; D001426:Bacterial Proteins / Q000235:genetics*; D001555:Benzene Derivatives / Q000378:metabolism; D015536:Down-Regulation; D015180:Electrophoresis, Gel, Two-Dimensional; D015964:Gene Expression Regulation, Bacterial / Q000235:genetics*; D015971:Gene Expression Regulation, Enzymologic / Q000235:genetics*; D006088:Gram-Negative Aerobic Bacteria / Q000201:enzymology / Q000235:genetics*; D008969:Molecular Sequence Data; D017386:Sequence Homology, Amino Acid; D013256:Steroids / Q000378:metabolism; D013739:Testosterone / Q000494:pharmacology*; D015854:Up-Regulation
chemical_list: D001426:Bacterial Proteins; D001555:Benzene Derivatives; D013256:Steroids; D013739:Testosterone