title: Increased prevalence of colonic polyps and altered lymphocyte subset pattern in the colonic lamina propria in acromegaly.
abstract: OBJECTIVE
  The balance of evidence suggests that acromegaly is a risk factor for colonic neoplasia. We have evaluated the prevalence of colonic polyps in acromegalics from Southern Italy and characterized the lymphocyte subsets in the colonic lamina propria in order to analyze differences in the colonic immunological environment.
  
  
  METHODS
  All the patients and controls were submitted to pancolonoscopy. Ten per-endoscopic biopsies of the intestinal mucosa surrounding polyps were carried out to evaluate lymphocyte subsets.
  
  
  METHODS
  Fifty acromegalics and 318 sex- and age-matched controls entered this study. Colonic lamina propria lymphocyte subsets were studied in 34 patients and 34 controls.
  
  
  RESULTS
  Colonic polyps were resected in 23 acromegalics (46%) and 42 controls (13.2%; P < 0.0001); hyperplastic polyps were found in 24% and 6.3%, adenomatous polyps in 22 and 6.9%, (P < 0.01), adenocarcinoma in 2 and 1.2% while synchronous polyps occurred in 18% and 2.5% (P < 0.01), respectively. The number of polyps was significantly correlated with age both in acromegalics (r = 0.422, P < 0.005) and in controls (r = 0.865, P < 0.001). However, polyp prevalence was greater in patients aged below 40 yrs (r.r = 1.9) and in patients with two or more skin tags (r.r = 1.2). A significant decrease of CD20, CD19, CD16, gamma/delta, CD4@leu8- and increase of CD3 and CD4+/leu8+ was found in the lamina propria lymphocyte subsets.
  
  
  CONCLUSIONS
  The results of this study confirm that acromegalics are at increased risk of colonic polyps compared to the healthy population. The increased prevalence of premalignant polyps, namely the adenomatous type, suggests that acromegalics should undergo a careful screening and follow-up by pancolonoscopy. An impairment of mucosal immune surveillance seems to exist in acromegaly although a causal effect in the polyp formation cannot be ruled out.
authors.affiliation: Department of Endocrinology, Federico II University, Naples, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Colao
authors.forename: A
authors.initials: A
authors.lastname: Balzano
authors.forename: D
authors.initials: D
authors.lastname: Ferone
authors.forename: N
authors.initials: N
authors.lastname: Panza
authors.forename: G
authors.initials: G
authors.lastname: Grande
authors.forename: P
authors.initials: P
authors.lastname: Marzullo
authors.forename: A
authors.initials: A
authors.lastname: Bove
authors.forename: G
authors.initials: G
authors.lastname: Iodice
authors.forename: B
authors.initials: B
authors.lastname: Merola
authors.forename: G
authors.initials: G
authors.lastname: Lombardi
mesh_terms: D000172:Acromegaly / Q000150:complications* / Q000276:immunology / Q000473:pathology; D000230:Adenocarcinoma / Q000150:complications / Q000276:immunology / Q000473:pathology; D018256:Adenomatous Polyps / Q000150:complications* / Q000276:immunology / Q000473:pathology; D000328:Adult; D000367:Age Factors; D000368:Aged; D001402:B-Lymphocytes / Q000473:pathology; D003106:Colon / Q000276:immunology* / Q000473:pathology; D003110:Colonic Neoplasms / Q000150:complications* / Q000276:immunology / Q000473:pathology; D003113:Colonoscopy; D005260:Female; D006801:Humans; D018655:Lymphocyte Count; D016131:Lymphocyte Subsets / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012306:Risk; D013601:T-Lymphocytes / Q000473:pathology