title: Genetic heterogeneity of migraine with and without aura in Danes cannot be explained by mutation in mtDNA nucleotide pair 11084.
abstract: BACKGROUND
  Migraine is a genetic heterogeneous disorder. The 11084 A to G base substitution is in the gene for the ND4 subunit of the respiratory complex I, and leads to a Thr to Ala amino acid replacement. This mutation had been found in 25% of Japanese migraineurs, while tension-type headache sufferers and non-migraineurs did not have it.
  
  
  METHODS
  We investigated the importance of this mutation in Danish migraineurs without aura, migraineurs with aura and non-migraineurs from the general population.
  
  
  RESULTS
  We did not detect this mutation in Danes.
  
  
  CONCLUSIONS
  Our result excludes a significant role of this mutation in the etiology of migraine in Denmark, and its absence in non-migraineurs supports that this mutation is rare in non-Japanese populations.
authors.affiliation: Department of Neurology, Glostrup Hospital, University of Copenhagen, Denmark.
authors.forename: M B
authors.initials: MB
authors.lastname: Russell
authors.forename: M
authors.initials: M
authors.lastname: Diamant
authors.forename: S
authors.initials: S
authors.lastname: Nørby
mesh_terms: D000328:Adult; D001482:Base Composition / Q000235:genetics; D004252:DNA Mutational Analysis; D004272:DNA, Mitochondrial / Q000235:genetics*; D003718:Denmark; D005260:Female; D005828:Genetics, Population; D006801:Humans; D008297:Male; D008881:Migraine Disorders / Q000235:genetics*; D009710:Nucleotide Mapping; D016133:Polymerase Chain Reaction
chemical_list: D004272:DNA, Mitochondrial