The way ahead in the management of unstable coronary artery disease.
Recent knowledge of the composition of coronary plaques is briefly reviewed, including factors that are considered to be responsible for the provocation of instability. Based on this information, possibilities for the early detection of threatening instability and measures to prevent destabilization of coronary plaques and to counteract thrombus formation are discussed.
Rydén
L
L
Department of Cardiology, Karolinska Hospital, Stockholm, Sweden.
Hamsten
A
A
D003094:Collagen / Q000378:metabolism; D003324:Coronary Artery Disease / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology* / Q000628:therapy*; D003328:Coronary Thrombosis / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control; D006801:Humans; D018836:Inflammation Mediators / Q000502:physiology; D008262:Macrophage Activation
D018836:Inflammation Mediators; D003094:Collagen