Complete nucleotide sequence of the HLA-DRB1 *1302 allele.
Sequencing studies of HLA class II molecules have focused almost exclusively on its exon 2. The complete cDNA sequence of the DRB*1302 allele is reported here for the first time. A conservative polymorphism was detected outside the exon 2 at residue 206; these changes can only be recorded if complete cDNA sequences are studied, and may be of value in drawing evolutive inferences.
Martinez-Quiles
N
N
Hospital Universitario 12 de Octubre, Universidad Complutense, Madrid, Spain.
Martin-Villa
J M
JM
Martinez-Laso
J
J
Ferre-Lopez
S
S
Alvarez
M
M
Gomez-Casado
E
E
de Juan
M D
MD
Arnaiz-Villena
A
A
D001483:Base Sequence; D018076:DNA, Complementary / Q000235:genetics; D005091:Exons / Q000235:genetics; D005260:Female; D005802:Genes, MHC Class II / Q000235:genetics*; D006684:HLA-DR Antigens / Q000032:analysis / Q000235:genetics*; D059810:HLA-DR Serological Subtypes; D059811:HLA-DRB1 Chains; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000235:genetics / Q000276:immunology; D008297:Male; D008969:Molecular Sequence Data; D011110:Polymorphism, Genetic; D017422:Sequence Analysis, DNA
D018076:DNA, Complementary; D006684:HLA-DR Antigens; D059810:HLA-DR Serological Subtypes; C097337:HLA-DR13 antigen; D059811:HLA-DRB1 Chains