[Diltiazem blood cardioplegia in patients of severe valvular heart disease].
This study was undertaken to analyze the effect of diltiazem blood cardioplegia (D-BCP) in patients of valvular heart disease with severe left ventricular dysfunction (EF = 56.3%, FS = 26.0%, CI = 2.241/min/m3), they were satisfied with NYHA functional class 3 and 4, also cardiothoracic ratio over 65%. By negative choronotropic action of D, the heart rates in D added group tend to be less than those of D free group 4 to 16 hours postoperatively, although that may diminish the incidence of ventricular arrhythmia postoperatively. D-BCP improved better functional recovery (mPAWP-LVSWI relation) during the early postoperative period than those seen in preoperatively. The pulmonary vascular resistance index of D added group showed significantly lower levels than those in the preoperative period, 0 to 16 hours after surgery. Consequently, D-BCP might be safe and provide superior protection for severe valvular heart disease.
Sasaki
A
A
Inoue
N
N
Tanaka
T
T
Yokoyama
H
H
Okamoto
F
F
Abe
T
T
Komatsu
S
S
D000368:Aged; D001769:Blood; D002121:Calcium Channel Blockers / Q000008:administration & dosage*; D004110:Diltiazem / Q000008:administration & dosage*; D005260:Female; D006324:Heart Arrest, Induced / Q000379:methods*; D006349:Heart Valve Diseases / Q000601:surgery*; D019918:Heart Valve Prosthesis Implantation; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000517:prevention & control; D017180:Tachycardia, Ventricular / Q000517:prevention & control; D018487:Ventricular Dysfunction, Left / Q000188:drug therapy
D002121:Calcium Channel Blockers; D004110:Diltiazem