title: Early response to inhaled nitric oxide and its relationship to outcome in children with severe hypoxemic respiratory failure.
abstract: OBJECTIVE
  To examine whether the early response to inhaled nitric oxide (iNO) is a measure of reversibility of lung injury and patient outcome in children with acute hypoxemic respiratory failure (AHRF).
  
  
  METHODS
  Retrospective review study.
  
  
  METHODS
  Pediatric ICUs.
  
  
  METHODS
  Thirty infants and children, aged 1 month to 13 years (median, 7 months) with severe AHRF (mean alveolar arterial oxygen gradient of 568+/-9.3 mm Hg, PaO2/fraction of inspired oxygen of 56+/-2.3, oxygenation index [OI] of 41+/-3.8, and acute lung injury score of 2.8+/-0.1). Eighteen patients had ARDS.
  
  
  METHODS
  The magnitude of the early response to iNO was quantified as the percentage change in OI occurring within 60 min of initiating 20 ppm iNO therapy. This response was compared to patient outcome data.
  
  
  RESULTS
  There was a significant association between early response to iNO and patient outcome (Kendall tau B r=0.43, p < 0.02). All six patients who showed < 15% improvement in OI died; 4 of the 11 patients (36%) who had a 15 to 30% improvement in OI survived, while 8 of 13 (61%) who had a > 30% improvement in OI survived. Overall, 12 patients (40%) survived, 9 with ongoing conventional treatment including iNO, and 3 with extracorporeal support.
  
  
  CONCLUSIONS
  In AHRF in children, greater early response to iNO appears to be associated with improved outcome. This may reflect reversibility of pulmonary pathophysiologic condition and serve as a bedside marker of disease stage.
authors.affiliation: Pediatric Intensive Care Units, Great Ormond Street Hospital for Children, London, United Kingdom.
authors.forename: A P
authors.initials: AP
authors.lastname: Goldman
authors.forename: R C
authors.initials: RC
authors.lastname: Tasker
authors.forename: S
authors.initials: S
authors.lastname: Hosiasson
authors.forename: T
authors.initials: T
authors.lastname: Henrichsen
authors.forename: D J
authors.initials: DJ
authors.lastname: Macrae
mesh_terms: D000208:Acute Disease; D000280:Administration, Inhalation; D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003422:Critical Care; D015199:Extracorporeal Membrane Oxygenation; D005260:Female; D006801:Humans; D000860:Hypoxia / Q000188:drug therapy* / Q000503:physiopathology; D007223:Infant; D008168:Lung / Q000187:drug effects / Q000503:physiopathology; D008297:Male; D009569:Nitric Oxide / Q000008:administration & dosage / Q000627:therapeutic use*; D010100:Oxygen / Q000097:blood; D010101:Oxygen Consumption / Q000187:drug effects; D011658:Pulmonary Fibrosis / Q000503:physiopathology; D011659:Pulmonary Gas Exchange / Q000187:drug effects; D012121:Respiration, Artificial; D012128:Respiratory Distress Syndrome / Q000188:drug therapy / Q000503:physiopathology; D012131:Respiratory Insufficiency / Q000188:drug therapy* / Q000503:physiopathology; D019141:Respiratory System Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D012189:Retrospective Studies; D015996:Survival Rate; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D019141:Respiratory System Agents; D009569:Nitric Oxide; D010100:Oxygen