title: The U1 snRNP complex: an autoantigen in connective tissue diseases. An update.
abstract: The U1 small nuclear ribonucleoprotein (snRNP) particle consists of an RNA backbone and eleven associated proteins. Both the RNA and some of the proteins are immunogenic in patients suffering from systemic lupus erythematosus or mixed connective tissue disease. An overview is given of the U1 snRNP particle with respect to its structure and function as well as its autoantigenicity.
authors.affiliation: Department of Biochemistry, University Hospital Nijmegen, The Netherlands.
authors.forename: J M
authors.initials: JM
authors.lastname: Klein Gunnewiek
authors.forename: L B
authors.initials: LB
authors.lastname: van de Putte
authors.forename: W J
authors.initials: WJ
authors.lastname: van Venrooij
mesh_terms: D001323:Autoantibodies / Q000276:immunology*; D001324:Autoantigens / Q000276:immunology*; D003240:Connective Tissue Diseases / Q000276:immunology*; D006801:Humans; D017412:Ribonucleoprotein, U1 Small Nuclear / Q000276:immunology*
chemical_list: D001323:Autoantibodies; D001324:Autoantigens; D017412:Ribonucleoprotein, U1 Small Nuclear