Alpha interferon gene deletions in post-transplant lymphoma.
Post-transplant lymphoproliferative disorder (PTLD) is a well-recognized complication of organ transplant and has been associated with high mortality using conventional chemotherapy. We have investigated 11 cases of PTLD for alterations to the interferon alpha (IFNA) and p16 genes on chromosome 9p using archival material. 4/9 (44%) cases had deletions of the IFNA genes, in contrast to 1/59 (1.7%) cases of intermediate/high-grade de novo NHL drawn from the same geographical region. PTLD may therefore represent a distinct NHL subgroup exhibiting distinct gene pathology.
Wood
A
A
University Department of Haematology, Medical School, Newcastle upon Tyne.
Angus
B
B
Kestevan
P
P
Dark
J
J
Notarianni
G
G
Miller
S
S
Howard
M
M
Proctor
S
S
Middleton
P
P
D002899:Chromosomes, Human, Pair 9 / Q000235:genetics*; D017353:Gene Deletion; D016259:Genes, myc; D019942:Genes, p16; D016027:Heart Transplantation / Q000009:adverse effects*; D006801:Humans; D016898:Interferon-alpha / Q000235:genetics*; D016030:Kidney Transplantation / Q000009:adverse effects*; D016040:Lung Transplantation / Q000009:adverse effects*; D008223:Lymphoma / Q000235:genetics*
D016898:Interferon-alpha