title: Secondary malignant fibrous histiocytoma following radiation therapy for carcinoma of the uterine cervix: report of two cases.
abstract: Two cases of secondary malignant fibrous histiocytoma (MFH) following radiation therapy for uterine cervical cancer are reported. The first case, a 48-year-old woman with a stage IB squamous cell carcinoma of the uterine cervix, underwent a radical hysterectomy with pelvic lymphadenectomy and postoperative radiation therapy. Five years later, she had a poorly differentiated MFH that originated in the right gluteal muscle and lung metastases. The right gluteal tumor and lung metastases were treated with radiation therapy and two courses of cisplatin and etoposide-based chemotherapy. One year after treatment the patient died of multiple pulmonary metastases, although there was no evidence of recurrence in the irradiated field. The second case, a 39-year-old woman with a stage IIB squamous cell carcinoma of the uterine cervix underwent radiation therapy alone. Eighteen years later, well differentiated MFH occurred in the right gluteal muscle with pain on elevation. External radiation therapy was performed because the tumor invaded widely to the right gluteal muscle and pelvic bone. Although the right gluteal pain improved, the tumor showed poor response to radiation. Ten months after treatment, the patient died of multiple pulmonary metastases. These two cases of postirradiation MFH demonstrated different responses to radiation.
authors.affiliation: Department of Radiology and Radiation Oncology, Gunma University School of Medicine, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Ohno
authors.forename: H
authors.initials: H
authors.lastname: Sakurai
authors.forename: Y
authors.initials: Y
authors.lastname: Saito
authors.forename: M
authors.initials: M
authors.lastname: Takahashi
authors.forename: T
authors.initials: T
authors.lastname: Fukusato
authors.forename: N
authors.initials: N
authors.lastname: Mitsuhashi
authors.forename: H
authors.initials: H
authors.lastname: Niibe
mesh_terms: D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000532:radiotherapy*; D003131:Combined Modality Therapy; D017809:Fatal Outcome; D005260:Female; D018219:Histiocytoma, Benign Fibrous / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D006801:Humans; D008875:Middle Aged; D019042:Muscle Neoplasms / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D009362:Neoplasm Metastasis; D009381:Neoplasms, Radiation-Induced / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D016609:Neoplasms, Second Primary / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D014057:Tomography, X-Ray Computed; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis / Q000532:radiotherapy*