title: DNA vaccines for malaria: the past, the present, & the future.
abstract: The first clinical trial of a DNA vaccine designed to protect against malaria has just commenced. This vaccine has been designed to induce protective CD8+ T cell responses against Plasmodium falciparum infected hepatocytes. Herein, we review the rationale behind the development of vaccines that induce protective CD8+ T cells, the strategy for the development of a DNA vaccine designed to protect against falciparum malaria, and the experimental data in rodent models and nonhuman primates which has provided the foundation for trials of DNA vaccines against P. falciparum malaria in humans.
authors.affiliation: Malaria Program, Naval Medical Research Institute, Bethesda, USA.
authors.forename: D L
authors.initials: DL
authors.lastname: Doolan
authors.forename: R C
authors.initials: RC
authors.lastname: Hedstrom
authors.forename: R
authors.initials: R
authors.lastname: Wang
authors.forename: M
authors.initials: M
authors.lastname: Sedegah
authors.forename: L F
authors.initials: LF
authors.lastname: Scheller
authors.forename: P
authors.initials: P
authors.lastname: Hobart
authors.forename: J A
authors.initials: JA
authors.lastname: Norman
authors.forename: S L
authors.initials: SL
authors.lastname: Hoffman
mesh_terms: D000818:Animals; D005544:Forecasting; D006801:Humans; D017780:Malaria Vaccines; D016778:Malaria, Falciparum / Q000517:prevention & control*; D010963:Plasmodium falciparum; D019444:Vaccines, DNA
chemical_list: D017780:Malaria Vaccines; D019444:Vaccines, DNA