Differences in humoral responses to the p24 antigen between Ethiopian and Swedish human immunodeficiency virus type 1-infected patients may suggest influences from a T-helper 2-like phenotype.
The levels of human immunodeficiency virus type 1 p24 antibodies and p24 antigen among 256 Ethiopians and Africans and 86 Swedes were compared. The elevated levels of total anti-p24 immunoglobulin G (IgG) and anti-p24 IgG4 among the Ethiopian and African patients suggest influences from T-helper-cell type 2-like responses.
Kebede
T
T
Department of Immunology, Microbiology, Pathology, and Infectious Diseases, Karolinska Institutet, Huddinge Hospital, Sweden.
Britton
S
S
Fehniger
T
T
Vahlne
A
A
Sällberg
M
M
D044383:Black People; D005002:Ethiopia; D015483:HIV Antibodies / Q000096:biosynthesis / Q000276:immunology*; D016655:HIV Core Protein p24 / Q000276:immunology*; D015658:HIV Infections / Q000208:ethnology / Q000276:immunology*; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D007124:Immunoenzyme Techniques; D007074:Immunoglobulin G / Q000096:biosynthesis / Q000276:immunology*; D010641:Phenotype; D013548:Sweden; D018418:Th2 Cells / Q000276:immunology*; D044465:White People
D015483:HIV Antibodies; D016655:HIV Core Protein p24; D007074:Immunoglobulin G