Clinicopathologic manifestations of Epstein-Barr virus-associated cutaneous lymphoproliferative disorders.
OBJECTIVE
To elucidate clinicopathologic manifestations of cutaneous lymphoproliferative disorders associated with Epstein-Barr virus (EBV) infection.


METHODS
Retrospective survey of case series.


METHODS
University hospital medical center.


METHODS
Sixty-five patients with cutaneous lymphomas and related disorders.


METHODS
Detection of EBV genes and EBV-encoded small nuclear RNAs.


RESULTS
Evidence of latent EBV infection was demonstrated in 15 patients: 3 had malignant lymphoma with clinical features mimicking cytophagic histiocytic panniculitis, 6 had facial vesiculopapular eruptions mimicking hydroa vacciniforme, 4 had angiocentric lymphoma, 1 had histiocytoid lymphoma associated with hemophagocytosis, and 1 had plasmacytoma. Hypersensitivity to mosquito bites was noted in a patient with hydroa vacciniforme-like eruptions and another with histiocytoid lymphoma. Angiocentric infiltration of atypical lymphoid cells was a common histological feature in the patients with hydroa vacciniforme-like eruptions and angiocentric lymphoma. No evidence of EBV infection was apparent in 19 patients with mycosis fungoides or Sézary syndrome, 7 with adult T-cell leukemia or lymphoma, 3 with lymphomatoid papulosis (type A), and 2 with lymphocytoma cutis.


CONCLUSIONS
Patients with EBV-associated cutaneous lymphoproliferative disorders present with unique and diagnostic clinicopathologic features distinct from those of mycosis fungoides or Sézary syndrome.
Iwatsuki
K
K
Department of Dermatology, Fukushima Medical College, Japan.
Ohtsuka
M
M
Harada
H
H
Han
G
G
Kaneko
F
F
D000293:Adolescent; D000328:Adult; D000368:Aged; D016375:Antisense Elements (Genetics); D001483:Base Sequence; D001706:Biopsy; D002648:Child; D017931:DNA Primers; D004279:DNA, Viral / Q000302:isolation & purification; D005260:Female; D006566:Herpesviridae Infections / Q000235:genetics / Q000473:pathology*; D004854:Herpesvirus 4, Human / Q000235:genetics; D006801:Humans; D017403:In Situ Hybridization / Q000379:methods; D008232:Lymphoproliferative Disorders / Q000235:genetics / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction / Q000379:methods; D012189:Retrospective Studies; D014412:Tumor Virus Infections / Q000235:genetics / Q000473:pathology*
D016375:Antisense Elements (Genetics); D017931:DNA Primers; D004279:DNA, Viral