Repair of adult rat corticospinal tract by transplants of olfactory ensheathing cells.
The upper cervical corticospinal tract was transected on one side in adult rats. A suspension of ensheathing cells cultured from adult rat olfactory bulb was injected into the lesion site. This induced unbranched, elongative growth of the cut corticospinal axons. The axons grew through the transplant and continued to regenerate into the denervated caudal host tract. Rats with complete transections and no transplanted cells did not use the forepaw on the lesioned side for directed reaching. Rats in which the transplanted cells had formed a continuous bridge across the lesion exhibited directed forepaw reaching on the lesioned side.
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The Norman and Sadie Lee Research Centre, Division of Neurobiology, National Institute for Medical Research, Medical Research Council, London NW7 1AA, UK.
Field
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PM
Raisman
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D000818:Animals; D001369:Axons / Q000502:physiology* / Q000648:ultrastructure; D016380:Brain Tissue Transplantation; D017690:Cell Transplantation; D002478:Cells, Cultured; D003714:Denervation; D005260:Female; D008854:Microscopy, Electron; D009186:Myelin Sheath / Q000502:physiology; D009416:Nerve Regeneration; D009457:Neuroglia / Q000502:physiology / Q000637:transplantation* / Q000648:ultrastructure; D009830:Olfactory Bulb / Q000166:cytology*; D009832:Olfactory Nerve / Q000166:cytology*; D051381:Rats; D013116:Spinal Cord / Q000502:physiology*; D013119:Spinal Cord Injuries / Q000601:surgery*