title: Cerebral primitive neuro-ectodermal tumour following treatment of a unilateral retinoblastoma.
abstract: Cerebral primitive neuro-ectodermal tumour (PNET) occurring as a second primary malignancy in childhood is exceedingly rare. We present a 7-year-old boy who developed a proven supratentorial PNET five years after enucleation and radio-/chemotherapy for a sporadic, unilateral retinoblastoma with optic nerve invasion. The association with this malignant eye disease as well as the effect of irradiation and multi-agent chemotherapy on second tumour induction are evaluated.
authors.affiliation: Clinic of Neurosurgery, Klagenfurt, Austria.
authors.forename: G
authors.initials: G
authors.lastname: Dorfmüller
authors.forename: F G
authors.initials: FG
authors.lastname: Würtz
authors.forename: R
authors.initials: R
authors.lastname: Kleinert
authors.forename: G
authors.initials: G
authors.lastname: Lanner
mesh_terms: D017024:Chemotherapy, Adjuvant; D002648:Child; D003131:Combined Modality Therapy; D015353:Eye Enucleation; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009361:Neoplasm Invasiveness; D016609:Neoplasms, Second Primary / Q000175:diagnosis* / Q000235:genetics; D018242:Neuroectodermal Tumors, Primitive / Q000175:diagnosis* / Q000235:genetics; D009900:Optic Nerve / Q000473:pathology; D011183:Postoperative Complications / Q000175:diagnosis*; D018714:Radiotherapy, Adjuvant; D019572:Retinal Neoplasms / Q000235:genetics / Q000628:therapy*; D012175:Retinoblastoma / Q000235:genetics / Q000628:therapy*; D012307:Risk Factors; D015173:Supratentorial Neoplasms / Q000175:diagnosis* / Q000235:genetics