From indomethacin to a selective COX-2 inhibitor. Development of indolalkanoic acids as potent and selective cyclooxygenase-2 inhibitors.
Lau
C K
CK
Merck Frosst Centre for Therapeutic Research, Pointe Claire-Dorval, Québec, Canada.
Black
W C
WC
Belley
M
M
Chan
C
C
Charleson
S
S
Denis
D
D
Gauthier
J Y
JY
Gordon
R
R
Guay
D
D
Hamel
P
P
Kargman
S
S
Leblanc
Y
Y
Mancini
J
J
Ouellet
M
M
Percival
D
D
Prasit
P
P
Roy
P
P
Skorey
K
K
Tagari
P
P
Vickers
P
P
Wong
E
E
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D002351:Carrageenan / Q000633:toxicity; D002860:Chromium Radioisotopes; D051545:Cyclooxygenase 1; D051546:Cyclooxygenase 2; D052246:Cyclooxygenase 2 Inhibitors; D016861:Cyclooxygenase Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D004064:Digestive System / Q000187:drug effects; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control; D005243:Feces / Q000737:chemistry; D005334:Fever / Q000139:chemically induced / Q000188:drug therapy; D007213:Indomethacin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology / Q000627:therapeutic use / Q000633:toxicity; D007527:Isoenzymes / Q000187:drug effects*; D008565:Membrane Proteins; D008968:Molecular Conformation; D015394:Molecular Structure; D009363:Neoplasm Proteins / Q000037:antagonists & inhibitors; D011451:Prostaglandin-Endoperoxide Synthases / Q000187:drug effects*; D051381:Rats; D013329:Structure-Activity Relationship; D013379:Substrate Specificity; D014407:Tumor Cells, Cultured
D000894:Anti-Inflammatory Agents, Non-Steroidal; D002860:Chromium Radioisotopes; D052246:Cyclooxygenase 2 Inhibitors; D016861:Cyclooxygenase Inhibitors; D007527:Isoenzymes; D008565:Membrane Proteins; D009363:Neoplasm Proteins; C109337:L 748780; D002351:Carrageenan; D051545:Cyclooxygenase 1; D051546:Cyclooxygenase 2; D011451:Prostaglandin-Endoperoxide Synthases; C496513:Ptgs1 protein, rat; D007213:Indomethacin