title: Ablation of interleukin-12 exacerbates Lyme arthritis in SCID mice.
abstract: The administration of interleukin-12 (IL-12) antibodies to Borrelia burgdorferi-infected C3H/HeN-scid mice increased the severity of acute Lyme arthritis. These results contrasted with the reduction of Lyme arthritis by IL-12 antibodies in immunocompetent animals. These data suggest that downregulation of innate immunity in SCID mice in the absence of B- and T-cell responses leads to an exacerbation of joint inflammation.
authors.affiliation: Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520-8031, USA.
authors.forename: J
authors.initials: J
authors.lastname: Anguita
authors.forename: S
authors.initials: S
authors.lastname: Samanta
authors.forename: S W
authors.initials: SW
authors.lastname: Barthold
authors.forename: E
authors.initials: E
authors.lastname: Fikrig
mesh_terms: D000818:Animals; D000906:Antibodies / Q000494:pharmacology; D016918:Arthritis, Reactive / Q000276:immunology* / Q000473:pathology; D004195:Disease Models, Animal; D018664:Interleukin-12 / Q000172:deficiency / Q000276:immunology*; D008193:Lyme Disease / Q000276:immunology* / Q000473:pathology; D051379:Mice; D008809:Mice, Inbred C3H; D016513:Mice, SCID; D013640:Tarsal Joints / Q000473:pathology
chemical_list: D000906:Antibodies; D018664:Interleukin-12