Cytologic study of ascites and the endometrium in ovarian carcinoma. Clinical significance.
OBJECTIVE
To ascertain the usefulness of endometrial cytology with ovarian cancers when examining extension of the disease and to analyze significant factors associated with migration of ovarian cancer cells into the uterine cavity.


METHODS
Cytologic results on ascites and the endometrium were analyzed in 87 patients with primary ovarian cancer in the absence of metastasis to the endometrium or cervicovagina.


RESULTS
Positive results for cytology were found in 62/87 of ascites cases (71.3%) and in 20/87 endometrium cases (23.0%). The 15 cases (15/62 or 24.2%) positive for ascitic and endometrial cytology, divided clinically into stage III (6 cases) and stage IV (9 cases), were classified histologically as serous, 7 cases; mucinous, 2 cases; clear cell, 4 cases; endometrioid, 1 case; and unclassified, 1 case. Half the clear cell carcinomas (4/8 or 50.0%) were positive in the ascites and endometrium. The ascitic volume at surgery exceeded 500 mL in 9/15 cases (60.0%).


CONCLUSIONS
Papillae with basement membrane material in the cores may be structurally associated with migration of ovarian cancer cells into the uterine cavity, especially in clear cell carcinomas. Cytologic positivity of the endometrium and ascites significantly correlated with ascitic volume.
Hirasawa
T
T
Department of Obstetrics and Gynecology, School of Medicine, Tokai University, Kanagawa, Japan.
Yasuda
M
M
Muramatsu
T
T
Itoh
H
H
Shinozuka
T
T
Makino
T
T
Tsutsumi
Y
Y
Osamura
R Y
RY
D018262:Adenocarcinoma, Clear Cell / Q000473:pathology; D002288:Adenocarcinoma, Mucinous / Q000473:pathology; D000328:Adult; D000368:Aged; D001201:Ascites / Q000473:pathology*; D001707:Biopsy, Needle; D002277:Carcinoma / Q000473:pathology*; D018269:Carcinoma, Endometrioid / Q000473:pathology; D018284:Cystadenocarcinoma, Serous / Q000473:pathology; D004717:Endometrium / Q000473:pathology*; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000473:pathology*; D014626:Vaginal Smears