Interleukins 6 and 8 as mediators of acute phase response in acute myocardial infarction.
The present study provides evidence that interleukin (IL)-6 and IL-8 are the main endogenous mediators of acute phase response in patients with myocardial infarction. This conclusion was supported by the observation of a strict relation between IL-6 elevation and the extent of myocardial tissue damage and rise in body temperature.
Pannitteri
G
G
Department of Cardiac Surgery, University La Sapienza, Rome, Italy.
Marino
B
B
Campa
P P
PP
Martucci
R
R
Testa
U
U
Peschle
C
C
D000210:Acute-Phase Reaction / Q000097:blood / Q000503:physiopathology*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood / Q000502:physiology*; D015850:Interleukin-6 / Q000097:blood / Q000502:physiology*; D016209:Interleukin-8 / Q000097:blood / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000188:drug therapy / Q000503:physiopathology*; D015912:Thrombolytic Therapy
D018836:Inflammation Mediators; D015850:Interleukin-6; D016209:Interleukin-8