[The transfer of antibacterial resistance to recipients highly sensitive to glanders].
In multiple experiments on golden hamsters, highly sensitive to glanders, the method of the transfer of antibacterial resistance was worked out. The most positive effect was obtained after the subcutaneous injection of saline-suspended marrow cells, obtained from white rats, infected with Burkholderia mallei C5 in a single inoculation and passaged through noninfected white rats 5 times. Out of 60 golden hamsters, treated with such material and subsequently (on day 21) injected with 1.0 x 10(2) B. mallei cells, 42 animals survived (70%).
Diadishchev
N R
NR
Vorob'eva
A A
AA
Zakharov
S B
SB
D000818:Animals; D019117:Burkholderia / Q000472:pathogenicity; D006224:Cricetinae; D004198:Disease Susceptibility; D005260:Female; D005896:Glanders / Q000276:immunology* / Q000382:microbiology / Q000473:pathology; D007113:Immunity, Innate; D007116:Immunization, Passive / Q000379:methods* / Q000706:statistics & numerical data; D008297:Male; D008647:Mesocricetus; D011549:Pseudomonas / Q000472:pathogenicity; D051381:Rats; D013045:Species Specificity; D014181:Transplantation Immunology / Q000276:immunology; D014774:Virulence