[Contribution of the midbrain raphe nuclei and locus ceruleus to realization of lithium hydrobutyrate rhythm modulating properties].
Electrolytic destruction of the median raphe nuclei or locus ceruleus (I = 1.5-2.0 V, 20 sec with a change of polarity) in the period of winter solstice weakens the manifestation of free flowing rhythms of the active-search component of behavior. Lithium hydroxybutyrate (10 mg/kg i.m. for one week) only after evening administration compensates the effects of lysis of the serotonin- or norepinephrine-containing stem cells on the behavioral rhythm. Whatever the phase of administration, the drug acts as a social time-assigner for body temperature rhythms under the indicated conditions.
Zamoshchina
T A
TA
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects* / Q000502:physiology; D001831:Body Temperature / Q000187:drug effects* / Q000502:physiology; D003624:Darkness; D006885:Hydroxybutyrates / Q000008:administration & dosage / Q000494:pharmacology*; D007273:Injections, Intramuscular; D008027:Light; D008094:Lithium / Q000494:pharmacology*; D008125:Locus Coeruleus / Q000166:cytology / Q000502:physiology*; D008297:Male; D009638:Norepinephrine / Q000378:metabolism; D009942:Organometallic Compounds / Q000008:administration & dosage / Q000494:pharmacology*; D010507:Periodicity; D011903:Raphe Nuclei / Q000166:cytology / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D012621:Seasons; D012701:Serotonin / Q000378:metabolism; D013234:Stem Cells / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D013696:Temperature
D006885:Hydroxybutyrates; D009942:Organometallic Compounds; D012701:Serotonin; C022826:lithium hydroxybutyrate; D008094:Lithium; D009638:Norepinephrine