Concurrent diagnosis of chronic lymphocytic leukemia and myelodysplastic syndrome.
An elderly patient is described with concurrent presentation of chronic lymphocytic leukemia and myelodysplastic syndrome, documented by clinical and hematological findings, flow cytometry and cytogenetics. The chromosome data suggested that these disorders developed as separate clones from two different hematopoietic precursor cells in this patient.
Sylvester
L S
LS
Pottstown Memorial Medical Center, Pennsylvania, USA.
Nowell
P C
PC
Bonner
H
H
Moreau
L
L
Moore
J S
JS
D000368:Aged; D000369:Aged, 80 and over; D001853:Bone Marrow / Q000473:pathology; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D025063:Chromosome Disorders; D002881:Chromosomes, Human, Pair 12; D005260:Female; D005434:Flow Cytometry; D006412:Hematopoietic Stem Cells / Q000473:pathology; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000150:complications* / Q000175:diagnosis / Q000235:genetics / Q000473:pathology; D009190:Myelodysplastic Syndromes / Q000150:complications* / Q000175:diagnosis / Q000235:genetics / Q000473:pathology; D014314:Trisomy