T helper cells driving pathogenic anti-DNA autoantibody production in lupus: nucleosomal epitopes and CD40 ligand signals.
Datta
S K
SK
Department of Medicine, Northwestern University Medical School, Chicago, IL 60611, USA.
Kaliyaperumal
A
A
Mohan
C
C
Desai-Mehta
A
A
D000818:Animals; D000974:Antibodies, Antinuclear / Q000096:biosynthesis* / Q000235:genetics / Q000276:immunology; D000918:Antibody Specificity; D001327:Autoimmune Diseases / Q000235:genetics / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology; D023201:CD40 Ligand; D003433:Crosses, Genetic; D004247:DNA / Q000276:immunology*; D004268:DNA-Binding Proteins / Q000276:immunology; D004195:Disease Models, Animal; D000939:Epitopes / Q000276:immunology*; D005786:Gene Expression Regulation; D005803:Genes, Immunoglobulin; D006657:Histones / Q000276:immunology; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics; D007135:Immunoglobulin Variable Region / Q000235:genetics; D008180:Lupus Erythematosus, Systemic / Q000235:genetics / Q000276:immunology*; D008181:Lupus Nephritis / Q000235:genetics / Q000276:immunology; D008213:Lymphocyte Activation; D008211:Lymphocyte Cooperation; D008562:Membrane Glycoproteins / Q000276:immunology*; D051379:Mice; D008814:Mice, Inbred NZB; D008815:Mice, Inbred Strains; D009707:Nucleosomes / Q000276:immunology*; D015398:Signal Transduction; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*
D000974:Antibodies, Antinuclear; D004268:DNA-Binding Proteins; D000939:Epitopes; D006657:Histones; D007143:Immunoglobulin Heavy Chains; D007135:Immunoglobulin Variable Region; D008562:Membrane Glycoproteins; D009707:Nucleosomes; D023201:CD40 Ligand; D004247:DNA