Development and evaluation of a kit formulation for the preparation of 99mTc-DMP-HSA, a new tracer agent for radionuclide ventriculography.
This study presents the development of a kit formulation for the preparation of 99mTc-DMP-HSA, followed by a comparison of such kit-prepared 99mTc-DMP-HSA to 99mTc-RBCs in a volunteer. Reconstitution of the labeling kits with up to 5.55 GBq 99mTc afforded 99mTc-DMP-HSA preparations with a > 95% radiochemical purity for up to 8 h. Only minor differences were observed in the global distribution of both tracer agents, whereas the calculated ejection fractions were almost identical. The effective dose equivalent of 99mTc-DMP-HSA is 8.68 microSv/MBq.
Verbeke
K A
KA
Laboratory of Radiopharmaceutical Chemistry, K.U. Leuven, Belgium.
Schiepers
C W
CW
Wyndaele
D N
DN
Baetens
J A
JA
Verbeke
G N
GN
De Roo
M J
MJ
Verbruggen
A M
AM
D006801:Humans; D008297:Male; D015609:Organotechnetium Compounds / Q000737:chemistry / Q000493:pharmacokinetics; D011786:Quality Control; D011829:Radiation Dosage; D015635:Radionuclide Ventriculography; D011933:Reagent Kits, Diagnostic; D013438:Sulfhydryl Compounds / Q000737:chemistry / Q000493:pharmacokinetics; D013668:Technetium Tc 99m Aggregated Albumin / Q000737:chemistry / Q000493:pharmacokinetics
D015609:Organotechnetium Compounds; D011933:Reagent Kits, Diagnostic; D013438:Sulfhydryl Compounds; D013668:Technetium Tc 99m Aggregated Albumin; C038842:technetium Tc 99m 2,3-dimercaptopropionic acid