Negative signaling in B cells: SHIP Grbs Shc.
Negative signaling in B cells is initiated by co-crosslinking of the antigen receptor and the Fcy receptor, resulting in cessation of B-cell signaling events and, in turn, inhibiting B-cell proliferation and antibody secretion. Here, a competitive role is proposed for SHIP in blocking the interaction of Shc with the Grb2-Sos complex of proteins that lead to Ras activation in B cells.
Tridandapani
S
S
Ohio State University, Dept of Microbiology, Columbus 43210, USA.
Kelley
T
T
Cooney
D
D
Pradhan
M
M
Coggeshall
K M
KM
D000486:Allergy and Immunology / Q000639:trends; D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D006801:Humans; D008954:Models, Biological; D000072183:Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases; D010744:Phosphoric Monoester Hydrolases / Q000276:immunology; D015398:Signal Transduction / Q000276:immunology*; D018631:ras Proteins / Q000276:immunology; D018909:src Homology Domains / Q000276:immunology
D010744:Phosphoric Monoester Hydrolases; C098706:INPPL1 protein, human; D000072183:Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases; D018631:ras Proteins