A comparison of clomiphene citrate and human menopausal gonadotropin for use in conjunction with intrauterine insemination.
OBJECTIVE
To compare the outcome of superovulation using clomiphene citrate (CC) versus hMG in conjunction with IUI.


METHODS
Sequentially assigned, observational study. Couples initially were assigned to receive either CC or hMG for three cycles.


METHODS
The Clinical Outpatient Department of the Dartmouth-Hitchcock Medical Center.


METHODS
Eighty-three infertile couples.


METHODS
IUI with hMG use.


METHODS
Conception rate, term pregnancy rate (PR), and pregnancy complications, such as spontaneous miscarriage and multiple gestation.


RESULTS
Of 83 couples who underwent at least one treatment cycle, 29 (35%) conceived during the study period. The relative rate of conception for hMG versus CC was 2.08 (95% confidence interval [CI], 0.93 to 4.68). The relative term PR was 2.10 (95% CI, 0.77 to 5.73) for hMG versus CC. There was no difference in the miscarriage rate for hMG versus CC.


CONCLUSIONS
Both the conception rate and the term PR were higher using hMG, compared with CC, in combination with IUI, and showed a trend toward statistical significance.
Manganiello
P D
PD
Department of Obstetrics and Gynecology, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire 03756-0001, USA.
Stern
J E
JE
Stukel
T A
TA
Crow
H
H
Brinck-Johnsen
T
T
Weiss
J E
JE
D000328:Adult; D002996:Clomiphene / Q000494:pharmacology*; D004958:Estradiol / Q000097:blood; D005260:Female; D005300:Fertility Agents, Female / Q000494:pharmacology*; D006801:Humans; D007317:Insemination, Artificial, Homologous; D008297:Male; D008596:Menotropins / Q000494:pharmacology*; D010060:Ovulation / Q000187:drug effects; D011247:Pregnancy
D005300:Fertility Agents, Female; D002996:Clomiphene; D004958:Estradiol; D008596:Menotropins