The LMP2 polymorphism is associated with susceptibility to acute anterior uveitis in HLA-B27 positive juvenile and adult Mexican subjects with ankylosing spondylitis.
BACKGROUND
An association between polymorphism of the HLA linked LMP2 locus and the development of acute anterior uveitis (AAU) has previously been described in B27 positive white subjects with ankylosing spondylitis (AS). This study evaluated LMP2 alleles in two HLA-B27 positive Mexican populations of patients with spondyloarthropathy known to have a different clinical spectrum of disease from white people.


METHODS
The study populations consisted of 90 AS patients from Guadalajara with predominantly adult onset disease and 80 AS patients from Mexico City with predominantly juvenile onset disease. LMP2-CfoI amplified fragment length polymorphisms were determined after polymerase chain reaction amplification and digestion with CfoI restriction enzyme.


RESULTS
There was an increased LMP2A allelic frequency in patients who had had AAU in both Guadalajara (31.8%) and Mexico City (33.3%) when compared with non-AAU patients (15.2% and 17.7% of Guadalajara and Mexico City populations, respectively). The odds ratio relating LMP2A allelic frequency and AAU for the combined population, stratified by age at onset of disease, was 2.51 (p = 0.01). LMP2 alleles did not influence the age at onset of disease or the development of peripheral arthritis.


CONCLUSIONS
These data support the view that polymorphism at the LMP2 locus is associated with the development of AAU in B27 positive subjects with AS. The requirement for both the less common LMP2 allele and HLA-B27 is consistent with the low prevalence of AAU in Mexican patients with spondyloarthritis.
Maksymowych
W P
WP
Department of Medicine, University of Alberta, Edmonton, Canada.
Jhangri
G S
GS
Gorodezky
C
C
Luong
M
M
Wong
C
C
Burgos-Vargas
R
R
Morenot
M
M
Sanchez-Corona
J
J
Ramos-Remus
C
C
Russell
A S
AS
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D002648:Child; D004198:Disease Susceptibility; D005260:Female; D015796:HLA-B27 Antigen; D006801:Humans; D008297:Male; D008800:Mexico; D008875:Middle Aged; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D013167:Spondylitis, Ankylosing / Q000150:complications / Q000208:ethnology / Q000235:genetics* / Q000276:immunology; D014606:Uveitis, Anterior / Q000150:complications / Q000235:genetics* / Q000276:immunology; D014763:Viral Matrix Proteins / Q000235:genetics*
C037662:EBV-associated membrane antigen, Epstein-Barr virus; D015796:HLA-B27 Antigen; D014763:Viral Matrix Proteins