Antitumor and antifertility activities of plumbagin controlled release formulations.
With a view to increase efficiency and reduce toxicity of Plumbagin, an attempt was made to formulate plumbagin as a controlled release preparation using various carriers and test for their antitumor and antifertility activities. Niosomes and albumin microspheres were used as carriers. In vitro data showed promising results for these formulations thus they were taken up for in vivo assessment. Given at a dose of 5 mg/kg, ip the albumin microspheres showed promising antitumor and antifertility activity when compared to the niosomes on control. Animal survival data also indicated slight improvement in survival rate and thus antitumoral activity. Also, an interesting point was that the antifertility activity was affected through an antiovulatory action as seen from histopathological studies.
Kini
D P
DP
College of Pharmaceutical Sciences, Manipal, India.
Pandey
S
S
Shenoy
B D
BD
Singh
U V
UV
Udupa
N
N
Umadevi
P
P
Kamath
R
R
Nagarajkumari
Ramanarayan
K
K
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage*; D003270:Contraceptive Agents / Q000008:administration & dosage*; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D005260:Female; D005298:Fertility / Q000187:drug effects; D008297:Male; D008546:Melanoma, Experimental / Q000188:drug therapy; D051379:Mice; D008810:Mice, Inbred C57BL; D008863:Microspheres; D009285:Naphthoquinones / Q000008:administration & dosage*; D010053:Ovary / Q000187:drug effects; D011247:Pregnancy; D051381:Rats
D000972:Antineoplastic Agents, Phytogenic; D003270:Contraceptive Agents; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D009285:Naphthoquinones; C014758:plumbagin