[Cytochrome P-450-dependent hydroxylation and activity of glutathione-dependent liver enzymes in chronic liver diseases].
Repression of cytochrom P-450-dependent hydroxylation and demethylation in liver was demonstrated in bioptats of patients with chronic liver diseases. The inhibition of cytochrome P450 system was provoked by oxidative modification of proteins-enzymes in patients with chronic liver changes as was proposed at the same time. The activation of glutathione-dependent enzymes was revealed. So the intensification of conjugation and development processes was revealed as the compensation mechanisms of detoxication with chronic liver diseases.
Matiushin
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Loginov
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Tkachev
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D002908:Chronic Disease; D065607:Cytochrome P-450 Enzyme Inhibitors; D005978:Glutathione / Q000378:metabolism*; D005979:Glutathione Peroxidase / Q000378:metabolism; D005980:Glutathione Reductase / Q000378:metabolism; D005982:Glutathione Transferase / Q000378:metabolism; D006801:Humans; D006900:Hydroxylation; D008099:Liver / Q000201:enzymology*; D008107:Liver Diseases / Q000201:enzymology*; D008862:Microsomes, Liver / Q000201:enzymology
D065607:Cytochrome P-450 Enzyme Inhibitors; D005979:Glutathione Peroxidase; D005980:Glutathione Reductase; D005982:Glutathione Transferase; D005978:Glutathione