title: Eosinophilic myositis/perimyositis: frequency and spectrum of cutaneous manifestations.
abstract: BACKGROUND
  Eosinophilic myositis/perimyositis (EM/P) are a group of rare idiopathic muscle disorders associated with eosinophilia.
  
  
  OBJECTIVE
  We describe the frequency and spectrum of cutaneous manifestations in EM/P and compare them with the idiopathic hypereosinophilic syndrome (HES).
  
  
  METHODS
  We review the literature on EM/P and describe an additional case associated with angioedema.
  
  
  RESULTS
  Of a total of 26 reported patients with EM/P, cutaneous manifestations were observed in 10. These were, in order of frequency, deep subcutaneous induration, erythema, angioedema, urticaria, and papular lesions.
  
  
  CONCLUSIONS
  Skin lesions occur less frequently in EM/P than in HES. Although erythematous papulonodular lesions and urticaria/angioedema are most commonly observed in HES, the most frequent skin manifestations of EM/P are subcutaneous induration and erythema. In HES, angioedema has been correlated with a favorable prognosis. At least some of these patients apparently have an idiopathic eosinophilic disorder distinct from HES, including EM/P. In contrast to HES, the overall prognosis of EM/P is good, particularly when muscle lesions are focal, and the principal histopathologic finding is perimysial infiltrates.
authors.affiliation: Department of Dermatology, University Hospital of Zurich, Switzerland.
authors.forename: R M
authors.initials: RM
authors.lastname: Trüeb
authors.forename: M
authors.initials: M
authors.lastname: Pericin
authors.forename: B
authors.initials: B
authors.lastname: Winzeler
authors.forename: B
authors.initials: B
authors.lastname: Wüthrich
authors.forename: G
authors.initials: G
authors.lastname: Burg
mesh_terms: D000328:Adult; D000368:Aged; D004802:Eosinophilia / Q000150:complications* / Q000473:pathology; D005260:Female; D006801:Humans; D017681:Hypereosinophilic Syndrome / Q000150:complications; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000473:pathology; D009220:Myositis / Q000150:complications* / Q000473:pathology; D012867:Skin / Q000473:pathology; D012871:Skin Diseases / Q000150:complications*