title: Excitotoxic lesions of histaminergic neurons by excitatory amino acid agonists in the rat brain.
abstract: Excitotoxic lesions of histaminergic (HA) neurons in the rat hypothalamus were observed by the injection of ibotenate and N-methyl-D-aspartate (NMDA) while kainate, quisqualate and quinolinate had no significant effects on HA neurons. An NMDA selective antagonist, 2-amino-5-phosphonopentanoic acid, was able to block the toxic effects of both NMDA and ibotenate almost completely, but kynurenate was a weaker inhibitor of ibotenate or NMDA-induced neurotoxicity. These results suggest that there exists an ibotenate-sensitive and quinolinate-insensitive NMDA receptor subtype on HA neurons.
authors.affiliation: Department of Pharmacology I, Tohoku University School of Medicine, Sendai, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Yanai
authors.forename: X L
authors.initials: XL
authors.lastname: Zhao
authors.forename: T
authors.initials: T
authors.lastname: Watanabe
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects*; D018690:Excitatory Amino Acid Agonists / Q000494:pharmacology*; D006632:Histamine / Q000378:metabolism*; D007031:Hypothalamus / Q000187:drug effects; D007051:Ibotenic Acid / Q000494:pharmacology; D008297:Male; D016202:N-Methylaspartate / Q000494:pharmacology; D009474:Neurons / Q000187:drug effects*; D009498:Neurotoxins / Q000494:pharmacology*; D016318:Quisqualic Acid / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar
chemical_list: D018690:Excitatory Amino Acid Agonists; D009498:Neurotoxins; D007051:Ibotenic Acid; D016202:N-Methylaspartate; D006632:Histamine; D016318:Quisqualic Acid