Stachybotrin C and parvisporin, novel neuritogenic compounds. I. Taxonomy, isolation, physico-chemical and biological properties.
Stachybotrin C and parvisporin, novel neuritogenic compounds, were isolated from the culture broth of Stachybotrys parvispora F4708. Stachybotrin C induced significant neurite outgrowth in PC12 cells and showed cell survival activity in the primary culture of cerebral cortical neurons. Parvisporin demonstrated only weak neuritogenic activity.
Nozawa
Y
Y
Medicinal Research Laboratories, Taisho Pharmaceutical Co., Ltd., Saitama, Japan.
Yamamoto
K
K
Ito
M
M
Sakai
N
N
Mizoue
K
K
Mizobe
F
F
Hanada
K
K
D000818:Animals; D001547:Benzaldehydes / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D001578:Benzopyrans / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D002540:Cerebral Cortex / Q000187:drug effects; D005233:Fatty Alcohols / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D005285:Fermentation; D007211:Indoles / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D009474:Neurons / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D013191:Stachybotrys
D001547:Benzaldehydes; D001578:Benzopyrans; D005233:Fatty Alcohols; D007211:Indoles; C108547:parvisporin; C108546:stachybotrin C