A case of amiodarone and neuromyopathy.
Amiodarone is a drug broadly used on cardiac arrhythmias despite its multiple side-effects. We present the case of an adult male with symptomatic ventricular tachycardia, receiving longterm amiodarone, who showed increased CK serum levels, sensorimotor neuropathy and secondary myopathy. Quadriceps biopsy showed atrophic changes and sural nerve intralysosomal deposits with intense axonal degeneration. The case illustrates the need to investigate and monitor peripheral neuropathy and muscular atrophy in chronic amiodarone use.
Silva Oropeza
E
E
Departamento de Electrofisiología y Arritmias, Hospital de Cardiología, CMN Siglo XXI, IMSS, México, D.F.
Peralta Rosado
H R
HR
Valero Elizondo
C
C
Sadowinski
E
E
Magaña Serrano
J A
JA
D000328:Adult; D000638:Amiodarone / Q000009:adverse effects* / Q000494:pharmacology; D000889:Anti-Arrhythmia Agents / Q000009:adverse effects*; D001284:Atrophy; D003402:Creatine Kinase / Q000097:blood; D004791:Enzyme Inhibitors / Q000009:adverse effects / Q000494:pharmacology; D006801:Humans; D002479:Inclusion Bodies / Q000648:ultrastructure; D007527:Isoenzymes; D008247:Lysosomes / Q000201:enzymology / Q000648:ultrastructure; D008297:Male; D018482:Muscle, Skeletal / Q000473:pathology; D009410:Nerve Degeneration; D009431:Neural Conduction; D009468:Neuromuscular Diseases / Q000097:blood / Q000139:chemically induced* / Q000473:pathology; D010292:Paresthesia / Q000139:chemically induced; D010740:Phospholipases / Q000037:antagonists & inhibitors; D013497:Sural Nerve / Q000473:pathology; D017180:Tachycardia, Ventricular / Q000188:drug therapy
D000889:Anti-Arrhythmia Agents; D004791:Enzyme Inhibitors; D007527:Isoenzymes; D003402:Creatine Kinase; D010740:Phospholipases; D000638:Amiodarone