title: Prophylaxis of experimental HTLV-I infection in cynomolgus monkeys by passive immunization.
abstract: The protective effect of purified human immunoglobulin against human T-cell leukaemia virus type I (HTLV-I), designated ATLIG on HTLV-I infection was examined in cynomolgus monkeys (Macaca fascicularis) as a preclinical study. Passive immunization of ATLIG 24 h before challenging HTLV-I protected the monkeys from HTLV-I infection. The result suggests that passive immunization of ATLIG could provide safe and sufficient protection against HTLV-I infection in humans.
authors.affiliation: Tsukuba Primate Center for Medical Science, National Institute of Health, Ibaraki, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Akari
authors.forename: T
authors.initials: T
authors.lastname: Suzuki
authors.forename: K
authors.initials: K
authors.lastname: Ikeda
authors.forename: H
authors.initials: H
authors.lastname: Hoshino
authors.forename: T
authors.initials: T
authors.lastname: Tomono
authors.forename: T
authors.initials: T
authors.lastname: Murotsuka
authors.forename: K
authors.initials: K
authors.lastname: Terao
authors.forename: H
authors.initials: H
authors.lastname: Ito
authors.forename: Y
authors.initials: Y
authors.lastname: Yoshikawa
mesh_terms: D000818:Animals; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D015490:HTLV-I Infections / Q000517:prevention & control*; D007116:Immunization, Passive; D008252:Macaca fascicularis; D008297:Male
chemical_list: D004279:DNA, Viral