title: Effect of some Indian herbs on macrophage functions in ochratoxin A treated mice.
abstract: The effect of Indian herbs namely, Asparagus racemosus, Tinospora cordifolia, Withania somnifera and Picrorhiza kurrooa on the functions of macrophages obtained from mice treated with the carcinogen ochratoxin A (OTA) was investigated. The chemotactic activity of murine macrophages was significantly decreased by 17 weeks of treatment with OTA compared with controls. Production of interleukin-1 (IL-1) and tumor necrosis factor (TNF) was also markedly reduced. Treatment with Asparagus racemosus, Tinospora cordifolia, Withania somnifera and Picrorhiza kurrooa significantly inhibited OTA-induced suppression of chemotactic activity and production of IL-1 and TNF-alpha by macropahges. Moreover, we found that Withania somnifera treated macrophage chemotaxis and that Asparagus racemosus induced excess production of TNF-alpha when compared with controls.
authors.affiliation: Department of Pharmacology and Toxicology, Research Centre, Hindustan Antibiotics Limited, Pimpri, India.
authors.forename: J N
authors.initials: JN
authors.lastname: Dhuley
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D002633:Chemotaxis / Q000187:drug effects*; D004797:Enzyme-Linked Immunosorbent Assay; D007194:India; D007375:Interleukin-1 / Q000096:biosynthesis*; D008264:Macrophages / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008519:Medicine, Traditional; D051379:Mice; D009183:Mycotoxins / Q000008:administration & dosage*; D009793:Ochratoxins / Q000008:administration & dosage*; D010936:Plant Extracts / Q000494:pharmacology; D010946:Plants, Medicinal; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis*
chemical_list: D007375:Interleukin-1; D009183:Mycotoxins; D009793:Ochratoxins; D010936:Plant Extracts; D014409:Tumor Necrosis Factor-alpha; C025589:ochratoxin A