title: Gallbladder motility after duodenum-preserving resection of the head of the pancreas.
abstract: BACKGROUND
  Duodenum-preserving resection of the head of the pancreas (DPRHP) is performed in patients with chronic pancreatitis (CP) localized in the head of the pancreas. It has been suggested that functional integrity of the upper digestive tract is preserved after DPRHP. We tested this hypothesis with regard to gallbladder motility.
  
  
  METHODS
  Gallbladder motility and cholecystokinin (CCK) secretion were studied fasting, after cephalic vagal stimulation with sham feeding, and after regular feeding in 9 patients after DPRHP, in 6 unoperated patients with CP, and 9 healthy control subjects.
  
  
  RESULTS
  Mean fasting gallbladder volume in patients after DPRHP (49 +/- 10 cm3) and patients with CP (53 +/- 10 cm3) was larger than in controls (33 +/- 3 cm3). Sham-feeding gallbladder contraction did not differ between patients after DPRHP, patients with CP, and controls. Both postprandial CCK secretion and gallbladder contraction in patients after DPRHP (78 +/- 16 pM. 120 min; 47% +/- 6%) and patients with CP (72 +/- 18 pM.120 min; 40% +/- 7%) were significantly reduced (P < 0.05) compared with controls (151 +/- 13 pM.120 min; 74% +/- 4%). Fasting gallbladder volume, sham feeding, and regular-feeding-induced gallbladder contraction and postprandial CCK secretion did not differ between operated and unoperated patients with CP.
  
  
  CONCLUSIONS
  Gallbladder motility and CCK secretion are reduced in patients with pancreatic insufficiency. A DPRHP procedure does not further influence these results. These findings support the concept that gallbladder motor function is preserved after DPRHP.
authors.affiliation: Dept. of General Surgery, University Hospital, Utrecht, The Netherlands.
authors.forename: E H
authors.initials: EH
authors.lastname: Eddes
authors.forename: A M
authors.initials: AM
authors.lastname: Masclee
authors.forename: H A
authors.initials: HA
authors.lastname: Gielkens
authors.forename: H G
authors.initials: HG
authors.lastname: Gooszen
authors.forename: C B
authors.initials: CB
authors.lastname: Lamers
mesh_terms: D000328:Adult; D002766:Cholecystokinin / Q000097:blood / Q000378:metabolism; D002908:Chronic Disease; D004386:Duodenum; D010188:Exocrine Pancreatic Insufficiency / Q000503:physiopathology / Q000601:surgery*; D005215:Fasting; D005260:Female; D005704:Gallbladder / Q000000981:diagnostic imaging / Q000502:physiology*; D016473:Gallbladder Emptying; D006801:Humans; D008297:Male; D008875:Middle Aged; D010179:Pancreas / Q000601:surgery; D010195:Pancreatitis / Q000503:physiopathology / Q000601:surgery*; D019518:Postprandial Period; D014463:Ultrasonography
chemical_list: D002766:Cholecystokinin