Solvent exposure and ratings of well-being: dose-effect relationships and consistency of data.
Ratings on analog scales for dimensions of well-being provide information about the acute state of well-being during solvent exposure. In a study of volunteers and workers exposed to solvents, tension, tiredness, complaints, and annoyance were rated on seven-point scales. Dose-effect relationships were analyzed for several scenarios; data were collected in diaries during work hours. In two studies, 40 volunteers in an exposure laboratory were exposed to ethanol by inhalation at levels between 80 and 1900 parts per million (ppm). In two other studies, 32 volunteers were exposed to acetone and ethyl acetate in single exposures (1000 and 500 ppm, respectively) and combined exposures (500 ppm acetone + 200 ppm ethyl acetate). A field study of 8 exposed workers and 8 nonexposed controls involved exposures of up to 2100 ppm acetone. Dose-effect relationships were shown for ratings of annoyance by correlations of 0.36 (ethanol) and 0.58 (acetone). Similar coefficients were found for ratings of complaints. The dimensions tension and tiredness showed no stable relationship with exposure. The consistency of ratings was assessed by means of correlations between the ratings given during periods of nearly equal exposures. Ratings of annoyance for the different studies between the periods of nearly equal exposure showed average correlations from 0.68 to 0.84. For the ratings of complaints, the coefficients were 0.53 to 0.81. The coefficients for tension had similar stabilities; those for tiredness were lower.
Seeber
A
A
Institute of Occupational Health, University of Dortmund, Dortmund, 44139, Germany.
Blaszkewicz
M
M
Golka
K
K
Kiesswetter
E
E
D000085:Acetates / Q000506:poisoning; D000096:Acetone / Q000506:poisoning; D000395:Air Pollutants, Occupational / Q000506:poisoning*; D003625:Data Collection / Q000592:standards*; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000506:poisoning; D006801:Humans; D016273:Occupational Exposure; D012997:Solvents / Q000506:poisoning*
D000085:Acetates; D000395:Air Pollutants, Occupational; D012997:Solvents; D000096:Acetone; D000431:Ethanol; C007650:ethyl acetate