[Mechanism of development of immunosuppression in acute renal insufficiency].
Immunosuppression caused by accumulation of antiproteolytic proteins and low-density lipoproteins and very low-density lipoproteins develops in acute renal failure (ARF) induced by HgCl2. An increase in the activity of antiproteolytic proteins occurs under the influence of factors of glass-adhering splenocytes whose elaboration is induced by heavy red blood cells modified by proteases. Lipoproteins give rise to the capacity of light red blood cells to activate the generation of suppressing cytokines by glass-adhering splenocytes. Lysozyme is an effective modulator in ARF.
Afanas'ev
V A
VA
Laskova
I L
IL
D058186:Acute Kidney Injury / Q000276:immunology*; D000276:Adjuvants, Immunologic / Q000502:physiology*; D000818:Animals; D007108:Immune Tolerance; D051381:Rats; D017208:Rats, Wistar; D013154:Spleen / Q000276:immunology*
D000276:Adjuvants, Immunologic