title: [Treatment outcome of radical cystectomy during a 10-year period (June 1984-September 1994) at Department of Urology, Fukui Medical School].
abstract: The treatment outcome was evaluated in 63 patients with bladder cancer more than 2 years after cystectomy. Cisplatin-based combination chemotherapies were given to 40 patients after the operation as an adjuvant therapy and two patients with T4 or N2 bladder cancer received chemotherapy before the operation as a neoadjuvant therapy. The extent of infiltration of the removed tumors was pTa in 5, pT1 in 18, pT2 in 8, pT3a in 6, pT3b in 17, and pT4 in 9 cases. Regional lymph node metastases were present in 10 cases (16%). Nineteen patients died of tumor recurrences. The 5-year acturial survival rates at each stage were 60% for stage pTa, 78% for stage pT1, 63% for stage pT2, 83% for stage pT3a, 33% for stage pT3b and 38% for stage pT4, respectively. A significant difference (p < 0.05) in survival curve was observed between pT3a and pT3b. The prognosis of patients with tumors extending beyond the bladder muscles is extremely unfavourable, with the exception of bladder cancers infiltrating the neighboring organ (pT4a), the removal of which may result in lasting survival in a part of the cases. Effective adjuvant treatment is required for patients with bladder tumors penetrating the bladder wall.
authors.affiliation: Department of Urology, Fukui Medical School.
authors.forename: S
authors.initials: S
authors.lastname: Saikawa
authors.forename: H
authors.initials: H
authors.lastname: Kanamaru
authors.forename: H
authors.initials: H
authors.lastname: Akino
authors.forename: S
authors.initials: S
authors.lastname: Nishibuchi
authors.forename: Y
authors.initials: Y
authors.lastname: Isomatsu
authors.forename: K
authors.initials: K
authors.lastname: Muranaka
authors.forename: Y
authors.initials: Y
authors.lastname: Kanimoto
authors.forename: K
authors.initials: K
authors.lastname: Okada
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002295:Carcinoma, Transitional Cell / Q000453:epidemiology / Q000601:surgery*; D015653:Cystectomy / Q000706:statistics & numerical data*; D005260:Female; D006785:Hospitals, University; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D001749:Urinary Bladder Neoplasms / Q000453:epidemiology / Q000601:surgery*; D014573:Urology Department, Hospital