title: Quantitation of regional cerebral blood flow increases during motor activation: a steady-state arterial spin tagging study.
abstract: Steady-state arterial spin tagging MRI approaches were used to quantitate regional cerebral blood flow increases during finger tapping tasks in seven normal subjects. Statistically significant increases in cerebral blood flow were observed in the contralateral primary sensorimotor cortex in all seven subjects and in the supplementary motor area in five subjects. The intrinsic spatial resolution of the cerebral blood flow images was approximately 4 mm. If no spatial filtering was applied, the average increase in cerebral blood flow in the activated primary sensorimotor cortex was 60 +/- 10 cc/100 g/min (91 +/- 32%). If the images were filtered to a spatial resolution of 15 mm, the average increase in cerebral blood flow in the activated primary sensorimotor cortex was 23 +/- 7 cc/100 g/min (42 +/- 15%), in agreement with previously reported 133Xe and PET results.
authors.affiliation: Clinical Brain Disorders Branch, NIMH, National Institutes of Health, Bethesda, Maryland 20892, USA.
authors.forename: F Q
authors.initials: FQ
authors.lastname: Ye
authors.forename: A M
authors.initials: AM
authors.lastname: Smith
authors.forename: Y
authors.initials: Y
authors.lastname: Yang
authors.forename: J
authors.initials: J
authors.lastname: Duyn
authors.forename: V S
authors.initials: VS
authors.lastname: Mattay
authors.forename: U E
authors.initials: UE
authors.lastname: Ruttimann
authors.forename: J A
authors.initials: JA
authors.lastname: Frank
authors.forename: D R
authors.initials: DR
authors.lastname: Weinberger
authors.forename: A C
authors.initials: AC
authors.lastname: McLaughlin
mesh_terms: D000328:Adult; D001921:Brain / Q000033:anatomy & histology*; D002536:Cerebral Arteries / Q000502:physiology*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D009044:Motor Cortex / Q000033:anatomy & histology / Q000098:blood supply; D011597:Psychomotor Performance / Q000502:physiology*; D013003:Somatosensory Cortex / Q000033:anatomy & histology / Q000098:blood supply