Prophylaxis of encephalopathies and risk factors of atherogenesis development in the postresuscitation period in rats by means of succinic acid.
The effect of oral administration of succinic acid was studied in 66 rats exposed to 10 min cardiac arrest with further resuscitation. A total of 30 mg/kg of the drug were administered daily for 5 days starting with day 3 up to day 7 after resuscitation. The experiments have revealed that treatment with succinic acid caused normalization of the orienting behavior in an 'open field' test, decrease of the intensity of response to electric shock, normalization of free radical formation in the brain and serum and reduced cerebral morphological changes. The succinic acid prevented the increase of cholesterol, triglyceride and low density lipoproteins in the blood. The data suggested that after additional trials the succinic acid could be used to prevent development of postresuscitation encephalopathies (3 months after reanimation).
Gurvitch
A M
AM
Research Institute of General Reanimatology, Russian Academy of Medical Sciences, Moscow, Russian Federation.
Mutuskina
E A
EA
Zarzhetsky
Y V
YV
Trubina
I E
IE
Avruschenko
M S
MS
Pylova
S I
SI
Volkov
A V
AV
Lazareva
N A
NA
Stepanichev
M Y
MY
Onufriev
M V
MV
Gulyaeva
N V
NV
D000818:Animals; D001161:Arteriosclerosis / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control*; D001522:Behavior, Animal / Q000187:drug effects; D002545:Brain Ischemia / Q000209:etiology / Q000517:prevention & control*; D016887:Cardiopulmonary Resuscitation / Q000009:adverse effects*; D004195:Disease Models, Animal; D006323:Heart Arrest / Q000188:drug therapy* / Q000628:therapy; D008074:Lipoproteins / Q000097:blood; D008297:Male; D051381:Rats; D011922:Rats, Mutant Strains; D012016:Reference Values; D012307:Risk Factors; D019802:Succinic Acid / Q000008:administration & dosage / Q000627:therapeutic use*; D015996:Survival Rate
D008074:Lipoproteins; D019802:Succinic Acid