title: Analysis of ahpC gene mutations in isoniazid-resistant clinical isolates of Mycobacterium tuberculosis.
abstract: The ahpC genes of 57 clinical isolates and one in vitro mutant of Mycobacterium tuberculosis were evaluated by nucleotide sequence analyses. Although compensatory ahpC promoter mutations were identified in 8 catalase-negative, katG-defective strains, the ahpC genes of 25 catalase-positive, isoniazid-resistant isolates and 25 drug-sensitive strains were not altered.
authors.affiliation: Laboratory of Mycobacteria, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA.
authors.forename: C L
authors.initials: CL
authors.lastname: Kelley
authors.forename: D A
authors.initials: DA
authors.lastname: Rouse
authors.forename: S L
authors.initials: SL
authors.lastname: Morris
mesh_terms: D000995:Antitubercular Agents / Q000494:pharmacology*; D001483:Base Sequence; D002374:Catalase / Q000378:metabolism; D004352:Drug Resistance, Microbial; D007538:Isoniazid / Q000494:pharmacology*; D009154:Mutation; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000201:enzymology / Q000235:genetics*; D010088:Oxidoreductases / Q000235:genetics*; D010544:Peroxidases; D054464:Peroxiredoxins; D010641:Phenotype
chemical_list: D000995:Antitubercular Agents; D010088:Oxidoreductases; D010544:Peroxidases; D054464:Peroxiredoxins; D002374:Catalase; D007538:Isoniazid