title: Fine needle aspiration biopsy of the salivary glands. A five-year experience with emphasis on diagnostic pitfalls.
abstract: OBJECTIVE
  To review the fine needle aspiration (FNA) findings in 151 patients who presented with salivary gland (both major and minor) enlargement from January 1991 to December 1995 in order to determine its sensitivity and specificity and to study the various pitfalls.
  
  
  METHODS
  The study group consisted of 77 males and 74 females, 16-98 years old (average 55). One hundred twenty-five aspirates (83%) were from the parotid gland, 23 (15%) from the submandibular gland and 3 (2%) from the soft palate. One hundred thirty-seven cases (91%) were adequate for diagnosis. There were 89 (59%) aspirations done by cytopathologists, 100% of which were diagnostic, and 62 (41%) done by clinicians, 48 (77%) of which were diagnostic. Sixty-eight (45%) cases had histologic confirmation. There were 104 (75.9%) benign, 20 (14.6%) malignant and 13 (9.5%) atypical cytologic diagnoses.
  
  
  RESULTS
  Using histology as the "gold standard," the sensitivity of FNA cytology was 91%, with a specificity of 96%. A number of problems were encountered in interpreting some cases, not only in differentiating benign from malignant ones but also in the specific classification of these neoplasms. Problems encountered involved differentiating hematopoietic from non-hematopoietic lesions and interpretation of spindle cell neoplasms, acinic cell carcinoma, mucoepidermoid carcinoma, adenoid cystic carcinoma, lymphoproliferative disorders, postirradiation changes, sialadenitis and atypia in pleomorphic adenoma.
  
  
  CONCLUSIONS
  FNA biopsy of the salivary gland is a sensitive and specific diagnostic tool at our institution. Particular attention to subtle morphologic changes may aid in avoiding pitfalls and arriving at the right diagnosis.
authors.affiliation: Department of Pathology, Northwestern University Medical School, Chicago, Illinois, USA.
authors.forename: R S
authors.initials: RS
authors.lastname: Cajulis
authors.forename: S T
authors.initials: ST
authors.lastname: Gokaslan
authors.forename: G H
authors.initials: GH
authors.lastname: Yu
authors.forename: D
authors.initials: D
authors.lastname: Frias-Hidvegi
mesh_terms: D008949:Adenoma, Pleomorphic / Q000473:pathology; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001707:Biopsy, Needle; D002277:Carcinoma / Q000473:pathology; D005260:Female; D006689:Hodgkin Disease / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D012468:Salivary Gland Neoplasms / Q000473:pathology*; D012469:Salivary Glands / Q000473:pathology*; D012680:Sensitivity and Specificity