title: Effects of acute administration of transdermal estrogen on postmenopausal women with systemic hypertension.
abstract: We studied 16 postmenopausal women with mild to moderate hypertension according to a randomized, double-blind protocol. They received patches of transdermal estradiol-17beta rated to deliver 100 mg/day of substance or matched placebo. A 24-hour ambulatory blood pressure (BP) monitoring was performed at baseline and after drug administrations. Our data show that estradiol-17beta exerts beneficial effects, both in lowering elevated BP levels and in maintaining a uniform BP control over 24 hours. Estrogen replacement therapy could be considered when significant changes in BP occur during the postmenopausal period.
authors.affiliation: The Institute of Cardiology, and Department of Obstetrics and Gynaecology, University of Cagliari, Sardinia, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Mercuro
authors.forename: S
authors.initials: S
authors.lastname: Zoncu
authors.forename: I
authors.initials: I
authors.lastname: Pilia
authors.forename: A
authors.initials: A
authors.lastname: Lao
authors.forename: G B
authors.initials: GB
authors.lastname: Melis
authors.forename: A
authors.initials: A
authors.lastname: Cherchi
mesh_terms: D000279:Administration, Cutaneous; D001794:Blood Pressure / Q000187:drug effects*; D001795:Blood Pressure Determination; D018592:Cross-Over Studies; D004311:Double-Blind Method; D004958:Estradiol / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000503:physiopathology; D008875:Middle Aged; D017698:Postmenopause
chemical_list: D004958:Estradiol