title: [An acellular pertussis vaccine based on the natural complex of antigens isolated from the supernatant of a synthetic culture medium].
abstract: A highly effective technology for obtaining a protective antigenic complex, including the main Bordetella pertussis protective antigens (pertussis toxin, filamentous hemagglutinin, agglutinogens, pertactin and adenylate cyclase) and isolated from the supernatant of B. pertussis cultivation medium, has been developed. A new method for the detoxication of antigenic complex which more available to preserve the protective property was suggested. Experimental batches of monovaccine and adsorbed DPT vaccine with the acellular pertussis component, possessing high protective activity and low histamine-sensitizing properties, have been obtained. The stability of protective properties both in liquid and lyophilized acellular pertussis preparations has been noted.
authors.forename: N S
authors.initials: NS
authors.lastname: Zakharova
authors.forename: T N
authors.initials: TN
authors.lastname: Remova
authors.forename: I G
authors.initials: IG
authors.lastname: Bazhanova
authors.forename: M H
authors.initials: MH
authors.lastname: Ozeretskovskaia
authors.forename: M V
authors.initials: MV
authors.lastname: Britsina
authors.forename: E I
authors.initials: EI
authors.lastname: Shmeleva
authors.forename: N U
authors.initials: NU
authors.lastname: Mertsalova
authors.forename: E I
authors.initials: EI
authors.lastname: Ermolova
authors.forename: E E
authors.initials: EE
authors.lastname: Sukhinova
authors.forename: V F
authors.initials: VF
authors.lastname: Bulk
authors.forename: A V
authors.initials: AV
authors.lastname: Sirotinskiĭ
authors.forename: A G
authors.initials: AG
authors.lastname: Poluiianova
authors.forename: V V
authors.initials: VV
authors.lastname: Sviridov
authors.forename: Iu P
authors.initials: IuP
authors.lastname: Vartanian
mesh_terms: D000818:Animals; D000942:Antigens, Bacterial / Q000276:immunology / Q000302:isolation & purification*; D001886:Bordetella pertussis / Q000276:immunology* / Q000472:pathogenicity; D003470:Culture Media; D015721:Diphtheria-Tetanus-Pertussis Vaccine / Q000276:immunology / Q000302:isolation & purification; D004306:Dose-Response Relationship, Immunologic; D007114:Immunization; D007116:Immunization, Passive; D051379:Mice; D010567:Pertussis Vaccine / Q000276:immunology / Q000302:isolation & purification*; D014774:Virulence / Q000276:immunology; D014917:Whooping Cough / Q000209:etiology / Q000517:prevention & control
chemical_list: D000942:Antigens, Bacterial; D003470:Culture Media; D015721:Diphtheria-Tetanus-Pertussis Vaccine; D010567:Pertussis Vaccine