title: [Centralized preparation in the pharmacy of dilute solutions of ganciclovir: (Cymevan): work load change and economic potential].
abstract: The production of ganciclovir doses by a hospital pharmacy having the necessary facilities to reconstitute anticancer drugs would be of the utmost relevance regarding both protection of the nursing staff and therapeutic safety. As this activity is also economically worthwhile a large number of our colleagues would like to implement it. The aim of this work has was to take advantage of a 40 weeks production of ganciclovir dose by the pharmacy at Rangueil hospital in Toulouse so as to answer some of the questions raised by such a project. The savings achieved by the team at Brabois hospital in Vandoeuvre les Nancy could therefore be validated. They are expressed in fraction of flask per dose produced (0,265). Applied to the number of doses that we delivered over a 40 week period, this coefficient enabled us to estimate from the only datum which is initially available to us, namely the number of flasks used, the extra work load and the savings that could be made: given steady activity, the number of doses the pharmacy will have to prepare is equal to the number of flasks multiplied by 1.418 and, provided one opts for a production process mostly in batches, the savings will be equivalent to 37.5% of the flasks.
authors.affiliation: Pharmacie CHU Rangueil, Toulouse, France.
authors.forename: R
authors.initials: R
authors.lastname: Teissier
authors.forename: J P
authors.initials: JP
authors.lastname: Lemozit
authors.forename: F
authors.initials: F
authors.lastname: Vabre
authors.forename: H
authors.initials: H
authors.lastname: De Bouet du Portal
authors.forename: J J
authors.initials: JJ
authors.lastname: Tiravy
authors.forename: S
authors.initials: S
authors.lastname: Pomies
authors.forename: R
authors.initials: R
authors.lastname: Bastide
mesh_terms: D019380:Anti-HIV Agents / Q000008:administration & dosage* / Q000191:economics*; D017046:Cost Savings; D004339:Drug Compounding; D015774:Ganciclovir / Q000008:administration & dosage* / Q000191:economics*; D010607:Pharmacy Service, Hospital; D012996:Solutions
chemical_list: D019380:Anti-HIV Agents; D012996:Solutions; D015774:Ganciclovir