[Do endogenous opioid peptides participate in the realization of the cardioprotective effect of adaptation?].
Twenty-four-hour immobilization stress induced heart damage (SHD). The agonist of mu-opioid receptors (OR) DAGO potentiated SHD. The agonist of peripheral mu-OR DALDA prevented SHD. Naltrexone decreased SHD. The peripheral mu-OR inhibitor methylnaltrexone potentiated SHD. Other OR ligands did not affect SHD. Acetorphane increased SHD. Repeated immobilization decreased the magnitude of myocardial damage. Neither naltrexone, naloxone, nor DAGO changed myocardial 99mTc pyrophosphate accumulation in the adapted rats.
Lishmanov
Iu B
IuB
Maslov
L N
LN
Naryzhnaia
N V
NV
D000222:Adaptation, Physiological; D000818:Animals; D004723:Endorphins / Q000502:physiology*; D006331:Heart Diseases / Q000517:prevention & control*; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D004723:Endorphins