title: [Lupic spinal cord diseases and antiphospholipid antibodies].
abstract: Central nervous system involvement in systemic lupus erythematosus (SLE) is frequent and severe, however, myelopathy is rarely reported (0.8 p. 100 of SLE cases). We describe two SLE-young women. They were 21 and 37 year old, presented with acute paraplegia. CSF study showed pleocytosis and moderately elevated protein. Antinuclear, anti-DNA and anticardiolipin were positive. High dose steroids therapy induced marked improvement. The pathogenesis of myelopathy in SLE remains unclear. Anti-phospholipid antibodies may cause thrombosis and ischemic myelopathy. However, auto-antibodies directed against central nervous system constituents may be involved.
authors.affiliation: Service de Neurologie, Centre Hospitalo-universitaire de Sfax, Tunisie.
authors.forename: I
authors.initials: I
authors.lastname: Feki
authors.forename: M
authors.initials: M
authors.lastname: Ben Hmida
authors.forename: H
authors.initials: H
authors.lastname: Masmoudi
authors.forename: C
authors.initials: C
authors.lastname: Triki
authors.forename: Z
authors.initials: Z
authors.lastname: Bahloul
authors.forename: J
authors.initials: J
authors.lastname: Hachicha
authors.forename: R
authors.initials: R
authors.lastname: Jlidi
authors.forename: C
authors.initials: C
authors.lastname: Mhiri
mesh_terms: D000328:Adult; D017152:Antibodies, Antiphospholipid / Q000032:analysis* / Q000502:physiology; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000188:drug therapy / Q000276:immunology; D008775:Methylprednisolone / Q000627:therapeutic use; D011241:Prednisone / Q000627:therapeutic use; D011379:Prognosis; D013118:Spinal Cord Diseases / Q000188:drug therapy / Q000209:etiology* / Q000276:immunology
chemical_list: D017152:Antibodies, Antiphospholipid; D005938:Glucocorticoids; D011241:Prednisone; D008775:Methylprednisolone