[Ecopathology of the kidneys and individual sensitivity to heavy metal salts].
Investigations performed in the region contaminated with heavy metal salts revealed high prevalence of renal diseases in children. The test for blood polymorphic proteins indicated signs of genetic predisposition to renal damage. Greater occurrence in the population with econephropathy of a rare allele of transferrin C3 may be the cause of enhanced oxidative-radical processes in renal cells. Individual sensitivity of children to heavy metal salts assessed by leukocytolysis and high incidence of somatic mutations to determine T-lymphocyte microclones deficient by HGPRT may help in specification of the affections detected in the regions contaminated with heavy metal salts.
Ignatova
M S
MS
Kharina
E A
EA
Spitsin
V A
VA
Dlin
V V
VV
Iur'eva
E A
EA
Osmanov
I M
IM
Raba
G P
GP
D000293:Adolescent; D002648:Child; D004198:Disease Susceptibility; D004785:Environmental Pollutants / Q000009:adverse effects*; D005260:Female; D005819:Genetic Markers; D006801:Humans; D007674:Kidney Diseases / Q000097:blood / Q000139:chemically induced* / Q000235:genetics; D008297:Male; D019216:Metals, Heavy / Q000009:adverse effects*; D018777:Multiple Chemical Sensitivity / Q000097:blood / Q000209:etiology* / Q000235:genetics; D010375:Pedigree; D012426:Russia; D014505:Urban Population
D004785:Environmental Pollutants; D005819:Genetic Markers; D019216:Metals, Heavy