Thrombospondin-1.
Thrombospondin-1 is a glycoprotein that is released from platelet alpha-granules in response to thrombin stimulation and that is also a transient component of extracellular matrix in developing and repairing tissues. It is a 420 kDa homotrimer, each subunit of which consists of multiple structural domains. A variety of factors regulate thrombospondin-1 expression and the protein is degraded by both extracellular and intracellular routes. Thrombospondin-1 functions as a cell adhesion molecule and also modulates cell movement, cell proliferation, neurite outgrowth and angiogenesis. The molecular mechanisms underlying these activities are beginning to be examined. Medical interest in thrombospondin-1 centres on its roles in haemostasis and its effects on angiogenesis.
Adams
J C
JC
MRC-Laboratory for Molecular Cell Biology, University College London, U.K.
D000818:Animals; D002320:Cardiovascular Physiological Phenomena; D015815:Cell Adhesion Molecules / Q000737:chemistry; D002874:Chromosome Mapping; D006801:Humans; D010452:Peptide Biosynthesis; D017434:Protein Structure, Tertiary; D013329:Structure-Activity Relationship; D019700:Thrombospondin 1 / Q000737:chemistry* / Q000502:physiology / Q000627:therapeutic use
D015815:Cell Adhesion Molecules; D019700:Thrombospondin 1