title: Efficacy of postoperative radiation therapy for recurrent squamous cell carcinoma of the head and neck.
abstract: OBJECTIVE
  Postoperative radiation therapy (RT) following surgical resection is often the recommended treatment for recurrent squamous cell carcinoma (SCC) of the head and neck. Despite common use, there are few published series evaluating such a management approach.
  
  
  METHODS
  We evaluated the efficacy of postoperative RT in 31 patients with recurrent SCC of the head and neck treated between 1981 and 1993. None of the patients had prior RT. All had complete resection of recurrent gross disease and no distant metastases. Maximum postoperative RT doses ranged from 59.4-70 Gy (median = 66 Gy).
  
  
  RESULTS
  The 5-year disease-specific survival (DSS) and local control (LC) rate for all patients were 32 and 46%, respectively. Several prognostic factors were analyzed including site and stage of original primary tumor, disease-free interval, site of recurrence, status of surgical margins, and dose. Only site of recurrence significantly influenced both DSS and LC. Patients whose recurrence was limited to previously undissected tissue had 5-year DSS and local control rates of 60 and 74%, respectively, as compared to 19 and 29%, respectively, for patients whose recurrence was within previously dissected tissue (p = 0.05).
  
  
  CONCLUSIONS
  Patients with recurrent SCC of the head and neck treated with standard postoperative RT following surgical resection do relatively well if the recurrence is within previously undissected tissue (i.e., nodal only); however, patients whose recurrence is within previously dissected tissue do poorly. Every effort to prevent locoregional disease recurrence at the time of primary therapy should be emphasized.
authors.affiliation: University of Kentucky Medical Center, Department of Radiation Medicine, Lexington, KY 40536-0084, USA.
authors.forename: W F
authors.initials: WF
authors.lastname: Regine
authors.forename: J
authors.initials: J
authors.lastname: Valentino
authors.forename: P
authors.initials: P
authors.lastname: Patel
authors.forename: D A
authors.initials: DA
authors.lastname: Sloan
authors.forename: M
authors.initials: M
authors.lastname: Mohiuddin
authors.forename: D E
authors.initials: DE
authors.lastname: Kenady
mesh_terms: D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D005260:Female; D006258:Head and Neck Neoplasms / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000532:radiotherapy*; D011879:Radiotherapy Dosage; D016019:Survival Analysis