title: Endotoxin regulates corticotropin-releasing hormone receptor 2 in heart and skeletal muscle.
abstract: We tested the effect of endotoxin on the peripheral corticotropin-releasing hormone receptor (CRH-R2), which is highly expressed in the heart. Systemic injection of LPS markedly downregulated CRH-R2 mRNA levels in the heart in a dose and time dependent manner. In contrast, CRH-R2 levels in skeletal muscle increased following exposure to endotoxin. These results suggest that CRH-R2 may be differentially regulated in cardiac tissue and skeletal muscle. Finding that CRH-R2 expression in the heart is modulated by endotoxin, a potent inducer of cardiovascular dysregulation, suggests a possible link between CRH and the cardiovascular response to stress.
authors.affiliation: Department of Molecular Microbiology and Immunology, Oregon Health Sciences University, Portland 97201-3098, USA.
authors.forename: K A
authors.initials: KA
authors.lastname: Heldwein
authors.forename: J E
authors.initials: JE
authors.lastname: Duncan
authors.forename: P
authors.initials: P
authors.lastname: Stenzel
authors.forename: M B
authors.initials: MB
authors.lastname: Rittenberg
authors.forename: M P
authors.initials: MP
authors.lastname: Stenzel-Poore
mesh_terms: D000818:Animals; D004926:Escherichia coli; D005260:Female; D005786:Gene Expression Regulation; D008070:Lipopolysaccharides / Q000494:pharmacology*; D051379:Mice; D008810:Mice, Inbred C57BL; D018482:Muscle, Skeletal / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism*; D018019:Receptors, Corticotropin-Releasing Hormone / Q000235:genetics*
chemical_list: D008070:Lipopolysaccharides; D012333:RNA, Messenger; D018019:Receptors, Corticotropin-Releasing Hormone