title: Giant congenital melanocytic nevi, neurocutaneous melanosis and neurological alterations.
abstract: BACKGROUND
  Magnetic resonance imaging (MRI) findings suggestive of neurocutaneous melanosis (NCM) have been reported in asymptomatic patients with giant congenital melanocytic nevi (GCMN).
  
  
  OBJECTIVE
  To investigate the presence of NCM and the clinical neurologic status of patients with GCMN involving the head an neck.
  
  
  METHODS
  Thirteen patients with GCMN involving the head and neck were clinically examined by pediatric specialists in dermatology, ophthalmology and neurology. Electroencephalograms, noncontrasted and contrasted computerized tomography (CT) scans and MRI were performed.
  
  
  RESULTS
  Eleven of 13 patients with GCMN of the head and neck previously considered asymptomatic were found to present mild but evident neurologic alterations. No signs of NCM were found in the CT scans or in the MRI.
  
  
  CONCLUSIONS
  Patients with GCMN of the head and neck may have associated neurologic alterations not related to the presence of neurocutaneous melanosis.
authors.affiliation: Department of Dermatology, National Institute of Neurology, Mexico City, Mexico.
authors.forename: R
authors.initials: R
authors.lastname: Ruiz-Maldonado
authors.forename: M
authors.initials: M
authors.lastname: del Rosario Barona-Mazuera
authors.forename: L R
authors.initials: LR
authors.lastname: Hidalgo-Galván
authors.forename: V
authors.initials: V
authors.lastname: Medina-Crespo
authors.forename: C
authors.initials: C
authors.lastname: Duràn-Mckinster
authors.forename: L
authors.initials: L
authors.lastname: Tamayo-Sánchez
authors.forename: M A
authors.initials: MA
authors.lastname: Mora-Tizcareño
authors.forename: A
authors.initials: A
authors.lastname: Zuloaga
authors.forename: M
authors.initials: M
authors.lastname: de la Luz Orozco-Covarrubias
mesh_terms: D000293:Adolescent; D000328:Adult; D002493:Central Nervous System Diseases / Q000150:complications / Q000175:diagnosis*; D002648:Child; D002675:Child, Preschool; D003937:Diagnosis, Differential; D004562:Electrocardiography; D005260:Female; D006257:Head; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging; D008297:Male; D008548:Melanosis / Q000150:complications / Q000175:diagnosis*; D009333:Neck; D009460:Neurologic Examination; D009508:Nevus, Pigmented / Q000150:complications / Q000151:congenital / Q000175:diagnosis*; D012878:Skin Neoplasms / Q000150:complications / Q000151:congenital / Q000175:diagnosis*; D014057:Tomography, X-Ray Computed