[Pharmacological correction of behavioral and memory disorders in rats with vasorenal arterial hypertension given propranolol].
It was established that propranolol in a daily dose of 2 mg/kg causes disturbance of behavior of rats with arterial hypertension in the open field, deteriorates retention of memory traces in passive avoidance paradigm, and leads to the development of depression in the test for zoosocial interrelation. Administration of nootropic piracetam (200 kg/mg/24 h). as well as the original compounds ACP-94 (20 mg/kg/24 h) and PIR-87--6-0 (50-mg/kg/24 h) facilitates the correction of negative changes in the behavior and memory of hypertensive rats.
Petrov
V I
VI
Grigorév
I A
IA
Gorbunov
S G
SG
D000284:Administration, Oral; D000818:Animals; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000627:therapeutic use / Q000633:toxicity*; D001224:Aspartic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000494:pharmacology; D001362:Avoidance Learning / Q000187:drug effects; D001522:Behavior, Animal / Q000187:drug effects*; D003863:Depression / Q000139:chemically induced; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D006977:Hypertension, Renal / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008568:Memory / Q000187:drug effects*; D018696:Neuroprotective Agents / Q000008:administration & dosage / Q000494:pharmacology*; D018697:Nootropic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D010889:Piracetam / Q000494:pharmacology; D011433:Propranolol / Q000008:administration & dosage / Q000627:therapeutic use / Q000633:toxicity*; D051381:Rats; D011918:Rats, Inbred SHR
D000959:Antihypertensive Agents; C103877:N-acetylaspartic acid di(3-dimethoxyphosphorylpropyl) ester; D018696:Neuroprotective Agents; D018697:Nootropic Agents; D001224:Aspartic Acid; D011433:Propranolol; D010889:Piracetam