title: [Autoregulation in ischemia of the optic nerve in the human].
abstract: BACKGROUND
  Autoregulation is defined as the maintenance of constant blood flow in a vascular system in spite of changes in perfusion pressure (PPm).
  
  
  METHODS
  PPm was decreased by increasing the intraocular pressure (IOP) with a suction cup and optic nerve blood flow was measured with the laser Doppler flowmetry technique (LDF) in 9 normal volunteers.
  
  
  RESULTS
  The blood flow was autoregulated down to a PPm of 13 mm Hg (IOP = 47 mm Hg).
  
  
  CONCLUSIONS
  These results confirm previous studies in cats and monkeys. The mechanism of autoregulation is probably a decrease in resistance due to capillary recruitment.
authors.affiliation: Institut de Recherches en Ophtalmologie, Sion.
authors.forename: P
authors.initials: P
authors.lastname: Titzé
authors.forename: M
authors.initials: M
authors.lastname: Hero
authors.forename: B L
authors.initials: BL
authors.lastname: Petrig
authors.forename: S D
authors.initials: SD
authors.lastname: Cranstoun
authors.forename: C E
authors.initials: CE
authors.lastname: Riva
mesh_terms: D000328:Adult; D002200:Capillary Resistance / Q000502:physiology*; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology; D007511:Ischemia / Q000503:physiopathology*; D017078:Laser-Doppler Flowmetry; D008297:Male; D008875:Middle Aged; D009900:Optic Nerve / Q000098:blood supply*; D012016:Reference Values