[The effect of some antioxidants on the response of selected lipid compounds in myocardium of rats].
Tests performed on 48 white rats were designed to evaluate the effect of such antioxidants as Allopurinol, Vitamin C, and Desferal on the lipid quantity in the rat heart muscle. The test animals were divided into control, Allopurinol, Vitamin C, and Desferal test groups in which free fatty acids, triglycerides, phospholipids, and total cholesterol were determined. It was observed that under the influence of Allopurinol and Vitamin C the heart muscle was bereaved of the essential energy compound, free fatty acids, to a large extent. This may be caused by the participation of these antioxidants in the redox reactions in organisms. The antioxidant applied in the experiments did not cause any changes in the contents of the other lipids under determination, i.e. triglycerides, phospholipids, and cholesterol. The maintenance of a constant level of these compounds is probably beneficial both for the heart and thus for the whole organism.
Janik
A
A
Katedra Patofizjologii, Zakład Patofizjologii Doświadczalnej, Collegium Medicum UJ.
Grabowska-Maślanka
H
H
D000493:Allopurinol / Q000494:pharmacology; D000818:Animals; D000963:Antimetabolites / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000494:pharmacology; D003676:Deferoxamine / Q000494:pharmacology; D006321:Heart / Q000187:drug effects*; D050356:Lipid Metabolism; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar
D000963:Antimetabolites; D000975:Antioxidants; D000493:Allopurinol; D003676:Deferoxamine; D001205:Ascorbic Acid