title: A nonsurgical approach to chronic anal fissure.
abstract: Both dilatation and sphincterotomy are sometimes followed by impaired continence. Recent experience with topical application of glyceryl trinitrate to relax the internal anal sphincter and cause reversible chemical sphincterotomy has shown promise as a first-line treatment.
authors.affiliation: University Hospital, Nottingham, United Kingdom.
authors.forename: J H
authors.initials: JH
authors.lastname: Scholefield
authors.forename: J N
authors.initials: JN
authors.lastname: Lund
mesh_terms: D000287:Administration, Topical; D002908:Chronic Disease; D005401:Fissure in Ano / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D005996:Nitroglycerin / Q000627:therapeutic use*; D010146:Pain / Q000209:etiology; D012307:Risk Factors; D016896:Treatment Outcome; D014665:Vasodilator Agents / Q000627:therapeutic use*
chemical_list: D014665:Vasodilator Agents; D005996:Nitroglycerin