title: Vancomycin prophylaxis and intraocular contamination during cataract surgery.
abstract: OBJECTIVE
  To investigate the effect of vancomycin added to the intraocular irrigation solution to prevent anterior chamber contamination during phacoemulsification.
  
  
  METHODS
  Centre Hospitalier, Villeneuve-Saint-Georges, France.
  
  
  METHODS
  A group of 372 patients having cataract extraction by phacoemulsification was divided into two consecutive, nonrandomized groups. The first group (n = 190) was a control; there was no antibiotic in the irrigation solution. The second group (n = 182) received vancomycin in the irrigation solution. Intraocular fluid was aspirated at the end of surgery and injected into a blood culture bottle to evaluate bacterial contamination of the anterior chamber.
  
  
  RESULTS
  There was no between-group difference in bacterial intraocular contamination. Eight samples in the first group were contaminated and nine in the second group. All contaminants were gram-positive vancomycin-sensitive organisms.
  
  
  CONCLUSIONS
  Adding vancomycin to the intraocular irrigation solution during cataract surgery had no effect on the occurrence of intraocular contamination as evaluated by anterior chamber taps.
authors.affiliation: Department of Ophthalmology, Centre Hospitalier Intercommunal, Villeneuve-Saint-Georges, France.
authors.forename: J
authors.initials: J
authors.lastname: Feys
authors.forename: A
authors.initials: A
authors.lastname: Salvanet-Bouccara
authors.forename: J P
authors.initials: JP
authors.lastname: Emond
authors.forename: A
authors.initials: A
authors.lastname: Dublanchet
mesh_terms: D000867:Anterior Chamber / Q000382:microbiology; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D019072:Antibiotic Prophylaxis; D009877:Endophthalmitis / Q000382:microbiology / Q000517:prevention & control; D004866:Equipment Contamination; D015818:Eye Infections, Bacterial / Q000209:etiology / Q000517:prevention & control; D005500:Follow-Up Studies; D006094:Gram-Positive Bacteria / Q000302:isolation & purification; D016908:Gram-Positive Bacterial Infections / Q000209:etiology / Q000517:prevention & control; D006801:Humans; D007910:Lenses, Intraocular; D018918:Phacoemulsification / Q000009:adverse effects*; D007507:Therapeutic Irrigation; D014640:Vancomycin / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D000900:Anti-Bacterial Agents; D014640:Vancomycin