title: Hyperosmolar hyperglycaemic syndrome in a dog resulting from parenteral nutrition overload.
abstract: A dog treated for a pancreatic abscess inadvertently received 1800 ml of hyperosmolar solution within a two hour period. Blood glucose reached 44 mmol/litre and the plasma osmolality was estimated to be more than 334 mOsm/litre. Lipaemia was severe and persisted for several days. The dog developed nausea, vomiting, depression, severe hyperglycaemia, polyuria, glucosuria and hypokalaemia. These symptoms were consistent with a hyperosmolar hyperglycaemic syndrome. Treatment with insulin and intravenous fluid rapidly corrected the hyperglycaemia, electrolyte imbalances and water deficits. The dog recovered and no long-term sequelae were observed.
authors.affiliation: Department of Veterinary Anaesthesiology, Radiology and Surgery, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Canada.
authors.forename: N M
authors.initials: NM
authors.lastname: Moens
authors.forename: A M
authors.initials: AM
authors.lastname: Remedios
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000188:drug therapy / Q000209:etiology*; D004285:Dogs; D006944:Hyperglycemic Hyperosmolar Nonketotic Coma / Q000188:drug therapy / Q000209:etiology / Q000662:veterinary*; D007328:Insulin / Q000627:therapeutic use; D008297:Male; D010288:Parenteral Nutrition / Q000009:adverse effects / Q000662:veterinary*
chemical_list: D007328:Insulin