The effects of hyperventilation on postural control mechanisms.
The effect of hyperventilation on postural balance was investigated. Voluntary hyperventilation increased body sway in normal subjects, particularly in the sagittal plane. The possibility that this hyperventilation-induced unsteadiness is due to interference with lower limb somatosensory input, vestibular reflexes or cerebellar function was assessed. (i) The effect of hyperventilation on peripheral compound sensory action potentials (SAPs) and somatosensory evoked potentials (SEPs) (recorded centrally, from the scalp) elicited by electrical stimulation of the sural nerve was measured in six normal adults. A reduction in the scalp SEP amplitude and an increase in the peripheral SAP amplitude were observed during hyperventilation, which reversed during the recovery period. These changes indicate increased peripheral neural excitability which could lead to a higher level of ectopic activity; the latter would interfere with central reception of peripheral input. (ii) The click-evoked vestibulo-collic reflex was recorded to study the effect of hyperventilation on vestibulo-spinal activity. EMG recordings from both sternocleidomastoid muscles of six healthy subjects were made in response to loud clicks presented to either ear. Neither the amplitude nor the latency of the response were altered significantly by hyperventilation. (iii) Eye-movement recordings were obtained in the six normal subjects to assess the effect of hyperventilation on the vestibulo-ocular reflex and its visual suppression, the latter being a function largely mediated by the cerebellum; no changes were detected. (iv) Three-dimensional eye-movement recordings and body-sway measurements were obtained in six patients with longstanding unilateral vestibular loss in order to evaluate if hyperventilation disrupts vestibular compensation. In all patients, a horizontal nystagmus either appeared or was significantly enhanced for > or = 60 s after voluntary hyperventilation. Sway was also enhanced by hyperventilation in these patients, particularly in the frontal plane. This study suggests that hyperventilation disrupts mechanisms mediating vestibular compensation. The increase in sway may be, at least partly, mediated by deranged peripheral and central somatosensory signals from the lower limbs. Hyperventilation seems to spare vestibular reflex activity and cerebellar-mediated eye movements.
Sakellari
V
V
MRC Human Movement and Balance Unit (Section of Neuro-otology), National Hospital for Neurology and Neurosurgery, London, UK.
Bronstein
A M
AM
Corna
S
S
Hammon
C A
CA
Jones
S
S
Wolsley
C J
CJ
D000161:Acoustic Stimulation; D000200:Action Potentials; D000328:Adult; D004576:Electromyography; D005073:Evoked Potentials, Somatosensory; D005260:Female; D006801:Humans; D006985:Hyperventilation / Q000503:physiopathology*; D008297:Male; D009334:Neck Muscles / Q000502:physiology; D009760:Nystagmus, Physiologic / Q000502:physiology; D011187:Posture / Q000502:physiology*; D011698:Pursuit, Smooth / Q000502:physiology; D012018:Reflex / Q000502:physiology; D012027:Reflex, Vestibulo-Ocular / Q000502:physiology; D012535:Scalp / Q000502:physiology; D012677:Sensation / Q000502:physiology; D013116:Spinal Cord / Q000502:physiology; D014722:Vestibule, Labyrinth / Q000502:physiology