CvSox-4, the lizard homologue of the human SOX4 gene, shows remarkable conservation among the amniotes.
SOX family genes share a high sequence similarity with the HMG box region of the human Y chromosomal gene, SRY. We have cloned and sequenced the HMG box motif of a Sox gene of the lizard, Calotes versicolor. A database search for the cloned sequence, CvSox-4, revealed 100% identity with the SOX4 gene of the human and its homologue in a bird. The result strongly suggests that SOX4 evolved prior to the diversification of amniotes and is highly conserved.
Ganesh
S
S
Department of Zoology, Banaras Hindu University, Varanasi, India.
Raman
R
R
D000595:Amino Acid Sequence; D000818:Animals; D003001:Cloning, Molecular; D017124:Conserved Sequence; D004268:DNA-Binding Proteins / Q000235:genetics; D004625:Embryo, Nonmammalian; D019143:Evolution, Molecular; D018507:Gene Expression Regulation, Developmental; D006609:High Mobility Group Proteins / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D008116:Lizards / Q000235:genetics*; D008297:Male; D008969:Molecular Sequence Data; D009687:Nuclear Proteins; D016133:Polymerase Chain Reaction; D055751:SOXC Transcription Factors; D017422:Sequence Analysis, DNA; D012689:Sequence Homology, Nucleic Acid; D012732:Sex Determination Analysis; D051876:Sex-Determining Region Y Protein; D015534:Trans-Activators / Q000235:genetics* / Q000378:metabolism; D014157:Transcription Factors; D014714:Vertebrates / Q000235:genetics
D004268:DNA-Binding Proteins; D006609:High Mobility Group Proteins; D009687:Nuclear Proteins; C083431:SOX4 protein, human; D055751:SOXC Transcription Factors; C497745:SRY protein, human; D051876:Sex-Determining Region Y Protein; D015534:Trans-Activators; D014157:Transcription Factors