Increased expression of alpha6-integrin receptors and of mRNA encoding the putative 37 kDa laminin receptor precursor in pancreatic carcinoma.
The expression of alpha6-integrin receptors (VLA-alpha6) and of mRNA encoding the putative 37 kDa laminin receptor precursor (37 LRP) was determined in ductal pancreatic adenocarcinoma and normal pancreatic tissue from the same patient. VLA-alpha6 expression was enhanced and redistributed in pancreatic carcinoma, and 37 LRP mRNA levels were elevated in carcinomatous pancreatic tissue as well as in five pancreatic tumor cell lines. The molecular weight of the major RNA species detected was higher in carcinoma tissue (1.9 kb) as opposed to cell lines (1.2 kb), possibly reflecting alternative splicing of 37 LRP mRNA in the primary tumor.
Halatsch
M E
ME
Department of Toxicology, University of Göttingen, Germany. halatsch@msvax.mssm.edu
Hirsch-Ernst
K I
KI
Kahl
G F
GF
Weinel
R J
RJ
D000230:Adenocarcinoma / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D015703:Antigens, CD / Q000096:biosynthesis*; D006801:Humans; D039503:Integrin alpha6; D010179:Pancreas / Q000276:immunology; D010190:Pancreatic Neoplasms / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D016133:Polymerase Chain Reaction; D012333:RNA, Messenger / Q000096:biosynthesis; D017474:Receptors, Laminin / Q000096:biosynthesis*; D016029:Receptors, Very Late Antigen / Q000096:biosynthesis*; D014158:Transcription, Genetic; D014407:Tumor Cells, Cultured; D015854:Up-Regulation
D015703:Antigens, CD; D039503:Integrin alpha6; D012333:RNA, Messenger; D017474:Receptors, Laminin; D016029:Receptors, Very Late Antigen