[Pancreatic polypeptide secreting endocrine pancreas tumor associated with multiple stomach and duodenal ulcers].
A 58-year-old woman presented with multiple gastroduodenal ulcera caused by a pancreatic polypeptidoma (PPoma) without hypergastrinemia or gastrin-producing tumor cells. After curative resection of the neoplasm, the clinical symptoms disappeared and the patient has now been disease-free for 6 years. We conclude that patients with non-gastrin-producing endocrine pancreatic tumors may demonstrate the clinical features of Zollinger-Ellison syndrome and should be included in the differential diagnosis of this syndrome.
Mehring
U M
UM
Institut für Allgemeine Pathologie und Pathologische Anatomie, Christian-Albrechts-Universität Kiel.
Jäger
H J
HJ
Klöppel
G
G
Hasse
F M
FM
D014408:Biomarkers, Tumor / Q000032:analysis; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008875:Middle Aged; D018358:Neuroendocrine Tumors / Q000175:diagnosis / Q000473:pathology / Q000601:surgery*; D010179:Pancreas / Q000473:pathology; D010190:Pancreatic Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000601:surgery*; D010191:Pancreatic Polypeptide / Q000378:metabolism*; D013004:Somatostatin / Q000032:analysis; D015043:Zollinger-Ellison Syndrome / Q000175:diagnosis / Q000473:pathology / Q000601:surgery*
D014408:Biomarkers, Tumor; D013004:Somatostatin; D010191:Pancreatic Polypeptide