title: Interaction between Entamoeba histolytica and intestinal epithelial cells involves a CD44 cross-reactive protein expressed on the parasite surface.
abstract: This study shows that Entamoeba histolytica binds hyaluronic acid. The binding molecule was identified as an 80-kDa membrane protein and was recognized by anti-CD44 monoclonal antibodies. These data indicate that a CD44 cross-reacting adherence molecule is expressed on E. histolytica.
authors.affiliation: Unité de Pathogénie Microbienne Moléculaire, Institut National de la Santé et de la Recherche Médicale U389, Institut Pasteur, Paris, France. prenesto@pasteur.fr
authors.forename: P
authors.initials: P
authors.lastname: Renesto
authors.forename: P J
authors.initials: PJ
authors.lastname: Sansonetti
authors.forename: N
authors.initials: N
authors.lastname: Guillén
mesh_terms: D000818:Animals; D018938:Caco-2 Cells; D002448:Cell Adhesion; D015815:Cell Adhesion Molecules / Q000276:immunology / Q000378:metabolism*; D002462:Cell Membrane / Q000737:chemistry / Q000378:metabolism; D003429:Cross Reactions; D004748:Entamoeba histolytica / Q000472:pathogenicity*; D004848:Epithelium / Q000469:parasitology; D006801:Humans; D018960:Hyaluronan Receptors / Q000276:immunology / Q000378:metabolism*; D006820:Hyaluronic Acid / Q000378:metabolism; D007413:Intestinal Mucosa / Q000469:parasitology*; D008565:Membrane Proteins / Q000276:immunology / Q000378:metabolism*; D011485:Protein Binding
chemical_list: D015815:Cell Adhesion Molecules; D018960:Hyaluronan Receptors; D008565:Membrane Proteins; D006820:Hyaluronic Acid