Electrostatic interaction of myristoylated proteins with membranes: simple physics, complicated biology.
Cell membrane association by several important peripheral proteins, such as Src, MARCKS, HIV-1 Gag, and K-Ras, requires nonspecific electrostatic interactions between a cluster of basic residues on the protein and acidic phospholipids in the plasma membrane. A simple theoretical model based on the nonlinear Poisson-Boltzmann equation describes well the experimentally measured electrostatic association between such proteins and the cell membrane.
Murray
D
D
Department of Physiology and Biophysics, SUNY Stony Brook 11794-8661, USA.
Ben-Tal
N
N
Honig
B
B
McLaughlin
S
S
D000595:Amino Acid Sequence; D002462:Cell Membrane / Q000737:chemistry*; D006801:Humans; D008969:Molecular Sequence Data; D019814:Myristic Acid; D009227:Myristic Acids / Q000737:chemistry*; D017711:Nonlinear Dynamics; D011506:Proteins / Q000737:chemistry*; D055672:Static Electricity
D009227:Myristic Acids; D011506:Proteins; D019814:Myristic Acid