A link between axon guidance and axon fasciculation suggested by studies of the tyrosine kinase receptor EphA5/REK7 and its ligand ephrin-A5/AL-1.
The possible roles of the tyrosine kinase receptor EphA5 and its ligand Ephrin-A5 in axon guidance and axon fasciculation are reviewed.
Caras
I W
IW
Department of Neuroscience, Genentech, Inc., 460 Pt. San Bruno Boulevard, South San Francisco, CA 94080, USA. ings@sirius.com
D000818:Animals; D001369:Axons / Q000502:physiology*; D036383:Ephrin-A2; D006801:Humans; D009474:Neurons / Q000502:physiology*; D020794:Receptor Protein-Tyrosine Kinases / Q000502:physiology*; D015398:Signal Transduction; D014157:Transcription Factors / Q000502:physiology*
D036383:Ephrin-A2; D014157:Transcription Factors; D020794:Receptor Protein-Tyrosine Kinases