[The anxiolytic effect of the new 2-mercaptobenzimidazole derivative in MR and MNRA rats].
The effect of the new drug SM-346, a derivative of 2-mercaptobenzimidazole, on the behavior of inbred MR and MNRA rats, differing in the phenotype of the emotional-stress reaction in the open field test was studies. In the Vogel conflict test SM-346 in a dose of 1 mg/kg produced an anxiolytic effect in MR rats but had no effect on the behavior of MNRA rats. The obtained results allow the conclusion that SM-346 possesses a selective anxiolytic action.
Seredinin
S B
SB
Viglinskaia
I V
IV
Kolik
L G
LG
D000284:Administration, Oral; D000818:Animals; D014151:Anti-Anxiety Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000633:toxicity*; D000963:Antimetabolites / Q000008:administration & dosage / Q000378:metabolism / Q000633:toxicity*; D001007:Anxiety / Q000139:chemically induced*; D001522:Behavior, Animal / Q000187:drug effects*; D001562:Benzimidazoles / Q000008:administration & dosage / Q000627:therapeutic use / Q000633:toxicity*; D003975:Diazepam / Q000008:administration & dosage / Q000494:pharmacology; D008297:Male; D010641:Phenotype; D051381:Rats; D011919:Rats, Inbred Strains; D012015:Reference Standards; D013045:Species Specificity; D013315:Stress, Psychological / Q000503:physiopathology
D014151:Anti-Anxiety Agents; D000963:Antimetabolites; D001562:Benzimidazoles; C030698:2-mercaptobenzimidazole; C108198:SM 346; D003975:Diazepam