[Changes in certain indicators of hemostasis in rabbits upon administration of Ebola virus preparations].
Changes in some parameters of hemostasis in rabbits insusceptible to Ebola virus (EV) in various periods after reinoculations with live and inactivated virus are described. Challenge with both control protein and live and inactivated EV leads to imbalance in the hemostasis system, which is compensated for in the course of follow-up and does not result in clinically manifest disorders of blood clotting. However, the mechanisms of development of the hemostasis imbalance caused by the control protein and virus preparations were different. In the former case no fibrinogen degradation products were detected in the blood serum, whereas in the latter they appeared in the serum after each reinoculation of the virus. This indicates a peculiar effect of EV on hemostasis.
Chepurnov
A A
AA
Dadaeva
A A
AA
Sizikova
L P
LP
Pisanko
V A
VA
D000818:Animals; D001778:Blood Coagulation Disorders; D029043:Ebolavirus / Q000276:immunology* / Q000502:physiology; D011517:Prothrombin Time; D011817:Rabbits; D018000:Receptors, Peptide / Q000097:blood; D015164:Vaccines, Inactivated / Q000008:administration & dosage; D014765:Viral Vaccines / Q000008:administration & dosage*; D014779:Virus Replication
D018000:Receptors, Peptide; D015164:Vaccines, Inactivated; D014765:Viral Vaccines; C048650:fibrin-fibrinogen degradation products receptor