title: Autonomic influences in atrial ischemia: vagally mediated atrial conduction improvement.
abstract: To investigate the effects of autonomic nerve activation on electrophysiological properties of ischemic atrial myocardium, experiments were performed in 10 open chest adult dogs anesthetized with xylazine and alpha-chloralose. Ischemia was created in the right atrial free wall by ligation of one or more branches of the right coronary artery. Bipolar electrograms were recorded from multiple sites in the ischemic and non-ischemic zones. The atria were paced at 400 ms and 180 ms to assess conduction properties. One hour after ligation, delayed activation, electrogram fractionation, and electrogram alternans were observed in the ischemic zone. All local conduction abnormalities were heart rate dependent in that they were only observed at a pacing cycle length of 180 ms. The average duration of ischemic zone electrograms was significantly prolonged from 17.7+/-1.6 ms to 26.4+/-1.6 ms (P<0.001). Right and left vagal stimulation significantly shortened the electrogram duration in the ischemic zone from 26.4+/-1.6 ms to 19.7+/-1.1 ms (P<0.01) and 20.0+/-1.1 ms (P<0.01), respectively. Ischemia-induced electrogram alternans was eliminated completely. During right and left stellate stimulation, electrogram duration was not altered and alternans was still present. In conclusion, vagal stimulation in this canine model improves local conduction in ischemic myocardium in the right atrium. This effect may be mediated by a reversal of the ischemia-induced membrane depolarization and a shortening of refractoriness in the atrium during vagal activation.
authors.affiliation: Loyola University Medical Center, Maywood, IL 60153, USA.
authors.forename: H
authors.initials: H
authors.lastname: Guo
authors.forename: D
authors.initials: D
authors.lastname: Euler
authors.forename: Z
authors.initials: Z
authors.lastname: Wang
authors.forename: B
authors.initials: B
authors.lastname: Olshansky
mesh_terms: D000818:Animals; D004285:Dogs; D005260:Female; D006321:Heart / Q000294:innervation*; D006325:Heart Atria / Q000503:physiopathology*; D006329:Heart Conduction System / Q000503:physiopathology*; D008297:Male; D017202:Myocardial Ischemia / Q000503:physiopathology*; D014630:Vagus Nerve / Q000503:physiopathology*