Bactericidal activity against intermediately cephalosporin-resistant Streptococcus pneumoniae in cerebrospinal fluid of children with bacterial meningitis treated with high doses of cefotaxime and vancomycin.
Cerebrospinal fluid (CSF) was taken from 19 children with bacterial meningitis treated with cefotaxime (300 mg/kg of body weight/day) and vancomycin (60 mg/kg/day). Median levels of drugs in CSF were smaller than expected, as follows: 4.4 microg/ml for cefotaxime, 3.2 microg/ml for desacetylcefotaxime, and 1.7 microg/ml for vancomycin. The median CSF bactericidal titer against an intermediately cefotaxime-resistant pneumococcus was 1:4. Our data suggest at least an additive interaction between the drugs used in this study.
Doit
C
C
Service de Microbiologie, Hôpital Robert Debré, Paris, France.
Barre
J
J
Cohen
R
R
Bonacorsi
S
S
Bourrillon
A
A
Bingen
E H
EH
D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000134:cerebrospinal fluid* / Q000627:therapeutic use*; D002439:Cefotaxime / Q000134:cerebrospinal fluid* / Q000627:therapeutic use*; D018550:Cephalosporin Resistance; D002511:Cephalosporins / Q000134:cerebrospinal fluid* / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D006801:Humans; D007223:Infant; D016920:Meningitis, Bacterial / Q000134:cerebrospinal fluid* / Q000188:drug therapy*; D008826:Microbial Sensitivity Tests; D011008:Pneumococcal Infections; D013296:Streptococcus pneumoniae; D014640:Vancomycin / Q000134:cerebrospinal fluid* / Q000627:therapeutic use*
D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D014640:Vancomycin; D002439:Cefotaxime