Differential pharmacological treatment response in high angry hostile and low angry hostile depressed patients: a retrospective analysis.
Fava et al., Am. J. Psychiatry 150 (1993)1158-1163, have recently proposed the existence of a sub-type of depressed patients who experience anger attacks. These investigators hypothesized that patients who experience anger attacks will respond better to a specific selective serotonin reuptake inhibitor (SSRI) medication than will depressed patients who do not experience anger attacks. Using a non-randomized, archival treatment methodology, 158 patients were classified as either high angry hostile (n = 83) or low angry hostile (n = 75). These patients had been treated with either a primarily noradrenergic reuptake inhibitor (desipramine) a SSRI (sertraline or paroxetine), or the combined serotonin and norepinephrine reuptake inhibitor (SNRI), venlafaxine. A 2 (high angry hostile/low angry hostile) x 3 (medication type) analysis of variance (ANOVA) was non-significant, indicating no differential treatment effects.
Bagby
R M
RM
Clarke Institute of Psychiatry, Toronto, Ontario, Canada. bagbym@cs.clarke-inst.on.ca
Kennedy
S H
SH
Schuller
D R
DR
Dickens
S E
SE
Minifie
C E
CE
Levitt
A
A
Joffe
R
R
D015057:1-Naphthylamine / Q000031:analogs & derivatives / Q000627:therapeutic use; D000328:Adult; D000553:Ambulatory Care; D000704:Analysis of Variance; D000786:Anger; D003511:Cyclohexanols / Q000627:therapeutic use; D003866:Depressive Disorder / Q000188:drug therapy* / Q000523:psychology; D003891:Desipramine / Q000627:therapeutic use; D005260:Female; D006791:Hostility; D006801:Humans; D008297:Male; D017374:Paroxetine / Q000627:therapeutic use; D012189:Retrospective Studies; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use*; D020280:Sertraline; D016896:Treatment Outcome; D000069470:Venlafaxine Hydrochloride
D015057:1-Naphthylamine; D003511:Cyclohexanols; D003891:Desipramine; D017374:Paroxetine; D017367:Selective Serotonin Reuptake Inhibitors; D020280:Sertraline; D000069470:Venlafaxine Hydrochloride