Controlled ovarian hyperstimulation: comparison between u-hFSH conventional protocol and a personalized approach.
OBJECTIVE
To investigate the therapeutic effectiveness in infertile couples with anovulatory, mild endometriosis-related and unexplained infertility of a personalized approach to controlled ovarian hyperstimulation (COH) (group A) on the basis of body mass index (BMI) and waist/hip ratio (WHR) in comparison to a conventional protocol (group B).


RESULTS
In group A, we obtained a significantly higher pregnancy rate and number of multifollicular cycles in comparison to group B. In addition, the pregnancy rate/ovulatory cycle and the number of ovulatory cycles were higher (but not significantly) in group A. In group B, we observed a not significantly higher number of monofollicular cycles and required length of stimulation in comparison to group A.


CONCLUSIONS
A personalized therapeutic protocol, based on simple criteria such as BMI and WHR, leads to a higher number of single and twin pregnancies, without any significant increase of higher grade multiple pregnancies or severe ovarian hyperstimulation syndrome.
Pellicano
M
M
Department of Gynecology and Obstetrics, University of Naples Federico II, Italy.
Zullo
F
F
Di Carlo
C
C
Mastrantonio
P
P
Nappi
C
C
D000328:Adult; D015992:Body Mass Index; D016009:Chi-Square Distribution; D018592:Cross-Over Studies; D004305:Dose-Response Relationship, Drug; D005260:Female; D005300:Fertility Agents, Female / Q000008:administration & dosage*; D005640:Follicle Stimulating Hormone / Q000008:administration & dosage*; D006801:Humans; D007247:Infertility, Female / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000209:etiology; D008596:Menotropins / Q000008:administration & dosage*; D010060:Ovulation / Q000187:drug effects / Q000502:physiology; D011085:Polycystic Ovary Syndrome / Q000150:complications; D011247:Pregnancy; D018873:Pregnancy Rate; D014463:Ultrasonography
D005300:Fertility Agents, Female; D008596:Menotropins; D005640:Follicle Stimulating Hormone