Comparison of aminosidine (paromomycin) and sodium stibogluconate for treatment of canine leishmaniasis.
Twelve dogs naturally infected with Leishmania infantum were treated subcutaneously with aminosidine at a dose of 10 mg kg-1 per day for four weeks. Antimonial compounds were used as reference drugs in twelve Leishmania-infected dogs. Eleven of the twelve dogs submitted to aminosidine therapy responded within 30 days. The treatment with the aminoglycoside antibiotic presented a marked decrease of anti-Leishmania antibody titres than the controls. Aminosidine also reduced urinary protein, serum IgG, and circulating immune complex concentrations. Side effects were observed only in a dog with pre-existent renal lesions. This study proved that aminosidine is an effective, tolerable and safe drug for the treatment of canine leishmaniasis and that it could be used as a suitable substitute for antimonial therapy.
Poli
A
A
Department of Animal Pathology, School of Veterinary Medicine, University of Pisa, Italy.
Sozzi
S
S
Guidi
G
G
Bandinelli
P
P
Mancianti
F
F
D000563:Amebicides / Q000627:therapeutic use; D000818:Animals; D000913:Antibodies, Protozoan / Q000097:blood; D000936:Antigen-Antibody Complex / Q000097:blood; D000953:Antigens, Protozoan / Q000097:blood; D000967:Antimony Sodium Gluconate / Q000627:therapeutic use*; D000981:Antiprotozoal Agents / Q000627:therapeutic use*; D004283:Dog Diseases; D004285:Dogs; D005260:Female; D007074:Immunoglobulin G / Q000097:blood; D018314:Leishmania infantum; D007898:Leishmaniasis, Visceral / Q000188:drug therapy / Q000503:physiopathology / Q000662:veterinary*; D008297:Male; D010303:Paromomycin / Q000627:therapeutic use*; D011507:Proteinuria; D013997:Time Factors
D000563:Amebicides; D000913:Antibodies, Protozoan; D000936:Antigen-Antibody Complex; D000953:Antigens, Protozoan; D000981:Antiprotozoal Agents; D007074:Immunoglobulin G; D010303:Paromomycin; D000967:Antimony Sodium Gluconate