Drug-resistance patterns of clinical isolates of Pseudomonas aeruginosa with reference to their lipopolysaccharide compositions.
Fifty-nine strains of Pseudomonas aeruginosa, isolated from blood, urine, pus, sputum and feces, were divided into three groups on the basis of differences in their LPS composition, in long- and short-LPS strains and in LPS-deficient strains. The long-LPS strains were far more frequently isolated among blood, urine and fecal specimens than in the remainder, and the frequency of LPS-deficient strains was higher in sputum specimens than in the remainder. The drug resistance patterns of the three LPS-type strains to six different kinds of anti-pseudomonal drugs, including gentamicin, differed significantly.
Hasegawa
M
M
Chemotherapy Division, Mitsubishi-Kagaku Bio-Clinical Laboratories, Tokyo, Japan.
Kobayashi
I
I
Saika
T
T
Nishida
M
M
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D005839:Gentamicins / Q000494:pharmacology*; D006801:Humans; D008070:Lipopolysaccharides / Q000032:analysis*; D011550:Pseudomonas aeruginosa / Q000737:chemistry / Q000187:drug effects* / Q000302:isolation & purification; D001618:beta-Lactamases / Q000096:biosynthesis
D000900:Anti-Bacterial Agents; D005839:Gentamicins; D008070:Lipopolysaccharides; D001618:beta-Lactamases