title: Elevated levels of circulating soluble adhesion molecules in peripheral blood of patients with unstable angina.
abstract: We have demonstrated increased levels of the circulating soluble adhesion molecules (sCAMs), ICAM-1, VCAM-1, and E-selectin in patients with unstable angina compared with healthy controls. Our findings support the role of inflammation in clinically unstable coronary disease, and may indicate a potential role for measurement of peripheral sICAM levels as a marker for inflammatory activity in atherosclerotic plaque.
authors.affiliation: Department of Cardiology, St. James's Hospital, Dublin, Republic of Ireland.
authors.forename: N K
authors.initials: NK
authors.lastname: Ghaisas
authors.forename: C N
authors.initials: CN
authors.lastname: Shahi
authors.forename: B
authors.initials: B
authors.lastname: Foley
authors.forename: M
authors.initials: M
authors.lastname: Goggins
authors.forename: P
authors.initials: P
authors.lastname: Crean
authors.forename: A
authors.initials: A
authors.lastname: Kelly
authors.forename: D
authors.initials: D
authors.lastname: Kelleher
authors.forename: M
authors.initials: M
authors.lastname: Walsh
mesh_terms: D000328:Adult; D000787:Angina Pectoris / Q000097:blood; D000789:Angina, Unstable / Q000097:blood*; D002637:Chest Pain / Q000097:blood; D003324:Coronary Artery Disease / Q000097:blood; D019040:E-Selectin / Q000097:blood*; D005260:Female; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D019010:Vascular Cell Adhesion Molecule-1 / Q000097:blood*
chemical_list: D019040:E-Selectin; D019010:Vascular Cell Adhesion Molecule-1; D018799:Intercellular Adhesion Molecule-1