title: Sestamibi scanning is inadequate for directing unilateral neck exploration for first-time parathyroidectomy.
abstract: OBJECTIVE
  To determine whether technetium Tc 99m sestamibi scanning is accurate enough to allow surgeons to perform unilateral neck exploration for first-time parathyroidectomy in patients with primary hyperparathyroidism.
  
  
  METHODS
  Retrospective review.
  
  
  METHODS
  University tertiary care center.
  
  
  METHODS
  Forty patients with primary hyperparathyroidism who underwent sestamibi scanning before first-time parathyroidectomy, of whom 28 had single adenomas, 9 had multiple adenomas, and 3 had hyperplasia.
  
  
  METHODS
  All 40 patients underwent bilateral neck exploration with identification of 4 parathyroid glands.
  
  
  METHODS
  We compared the results of preoperative sestamibi scanning with operative and histologic findings. We then used these data to calculate the projected success rates of parathyroidectomy if unilateral neck explorations had been performed based on the results of sestamibi scanning, instead of bilateral explorations.
  
  
  RESULTS
  Sestamibi scanning was correct in 20 (71%) of 28 patients with single adenomas, 4 (44%) of 9 patients with multiple adenomas, and 0 (0%) of 3 patients with hyperplasia. If unilateral neck explorations had been performed on the basis of localization by sestamibi scanning, parathyroidectomy would have failed in 4 (10%) of 40 patients.
  
  
  CONCLUSIONS
  Sestamibi scanning, although helpful, is inadequate for directing unilateral neck exploration for first-time parathyroidectomy. Surgeons who perform unilateral neck exploration based on the results of sestamibi scanning will record a higher failure rate and incur higher costs than those who perform bilateral neck exploration for first-time parathyroidectomy.
authors.affiliation: Department of Surgery, University of California-San Francisco/Mount Zion Medical Center, USA.
authors.forename: W
authors.initials: W
authors.lastname: Shen
authors.forename: U
authors.initials: U
authors.lastname: Sabanci
authors.forename: E T
authors.initials: ET
authors.lastname: Morita
authors.forename: A E
authors.initials: AE
authors.lastname: Siperstein
authors.forename: Q Y
authors.initials: QY
authors.lastname: Duh
authors.forename: O H
authors.initials: OH
authors.lastname: Clark
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D005260:Female; D006801:Humans; D006961:Hyperparathyroidism / Q000000981:diagnostic imaging / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009333:Neck; D010280:Parathyroid Glands / Q000000981:diagnostic imaging*; D016105:Parathyroidectomy / Q000379:methods*; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D017256:Technetium Tc 99m Sestamibi; D016896:Treatment Outcome
chemical_list: D019275:Radiopharmaceuticals; D017256:Technetium Tc 99m Sestamibi