Surgical treatment of dysplasia and adenocarcinoma.
It is currently recommended that patients with Barrett's esophagus who are medically fit be enrolled in a surveillance program and undergo 1 to 2 yearly endoscopy examinations with multiple biopsies. An acceptable protocol for these purposes requires obtaining four biopsy specimens, one from each quadrant of the esophagus, every 2 cm along the visible length of the Barrett's mucosa, with additional biopsy specimens from any abnormal-appearing area. Patients in surveillance programs are directed for further therapy if they develop low-grade or high-grade dysplasia or invasive adenocarcinoma.
DeMeester
T R
TR
Department of Surgery, University of Southern California School of Medicine, Los Angeles, USA.
D000230:Adenocarcinoma / Q000601:surgery* / Q000628:therapy; D000465:Algorithms; D001471:Barrett Esophagus / Q000601:surgery* / Q000628:therapy; D003131:Combined Modality Therapy; D004938:Esophageal Neoplasms / Q000601:surgery* / Q000628:therapy; D016629:Esophagectomy; D004947:Esophagus / Q000473:pathology; D006801:Humans