title: Renal artery stenosis: detection and quantification with spiral CT angiography versus optimized digital subtraction angiography.
abstract: OBJECTIVE
  To compare spiral computed tomographic (CT) angiography with optimized digital subtraction angiography (DSA) for accurate detection and quantification of renal artery stenosis.
  
  
  METHODS
  In 71 consecutive patients with possible renovascular hypertension, spiral CT angiography was performed of the renal arteries before DSA. Optimized DSA (performed with projection angles calculated from axial spiral CT source images) was used as the standard. Two independent observers evaluated spinal CT angiograms for the presence and grade of renal artery stenosis. Sensitivity, specificity, and interobserver variability were calculated.
  
  
  RESULTS
  With spiral CT angiography, all 166 renal arteries and accessory arteries were identified correctly by both reviewers. Overall sensitivity and specificity for assessment of stenoses of grade 0 (none), grade 1 (1%-49%), grade 2 (51%-99%), and grade 3 (occlusion) were 97% and 100%, 92% and 98%, 96% and 96%, and 100% and 100%, respectively. Agreement was strong between spiral CT angiographic and DSA findings in assessment of all grades of stenosis (kappa coefficient, 0.9 and 0.9, respectively) for the two observers.
  
  
  CONCLUSIONS
  Spiral CT angiography enabled accurate assessment of renal artery stenosis in patients with possible renovascular hypertension and may assist in selecting patients for interventional treatment.
authors.affiliation: Department of Radiology, University Hospital Utrecht, The Netherlands.
authors.forename: R
authors.initials: R
authors.lastname: Kaatee
authors.forename: F J
authors.initials: FJ
authors.lastname: Beek
authors.forename: E E
authors.initials: EE
authors.lastname: de Lange
authors.forename: M S
authors.initials: MS
authors.lastname: van Leeuwen
authors.forename: H F
authors.initials: HF
authors.lastname: Smits
authors.forename: P J
authors.initials: PJ
authors.lastname: van der Ven
authors.forename: J J
authors.initials: JJ
authors.lastname: Beutler
authors.forename: W P
authors.initials: WP
authors.lastname: Mali
mesh_terms: D000328:Adult; D000368:Aged; D015901:Angiography, Digital Subtraction; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015588:Observer Variation; D012077:Renal Artery / Q000000981:diagnostic imaging*; D012078:Renal Artery Obstruction / Q000000981:diagnostic imaging*; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed