Time-dependent blockade of STP and LTP in hippocampal slices following acute stress in mice.
The characteristics of short-term potentiation (STP) and long-term potentiation (LTP) in the CA1 region of hippocampal slices were determined at various times following exposure to acute stress produced by restraint and tail-shock in mice. In slices prepared from control animals, theta-burst stimulation resulted in a large increase in evoked field excitatory postsynaptic potentials (EPSPs) amplitude and slope that remained stable at least up to 30 min after stimulation. Slices prepared 1 h after stress exhibited a marked decrease in the extent of both STP and LTP. STP and LTP magnitude were still significantly decreased 24 h after stress exposure and were completely restored to control levels by 48 h. These results provide evidence for a reversible impairment of STP and LTP in CA1 following an acute episode of stress, and suggest that stress activates processes different from those activated by LTP-inducing stimuli.
Garcia
R
R
Laboratoire de Neurosciences Comportementales et Cognitives, CNRS URA 339, Université de Bordeaux, Talence, France. garcia@neurocog.u-bordeaux.fr
Musleh
W
W
Tocco
G
G
Thompson
R F
RF
Baudry
M
M
D000818:Animals; D006624:Hippocampus / Q000502:physiology*; D017774:Long-Term Potentiation / Q000502:physiology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D013312:Stress, Physiological / Q000503:physiopathology*; D009435:Synaptic Transmission / Q000502:physiology; D013997:Time Factors