title: Cluster of wound botulism in California: clinical, electrophysiologic, and pathologic study.
abstract: Over a period of 15 months we have seen 6 patients with long-standing history of subcutaneous heroin injections who experienced acute blurred vision, dysphagia, dysarthria, and generalized weakness. Decreased or absent deep tendon reflexes, pupillary abnormalities, incremental responses to fast repetitive nerve stimulation, and positive serology for Clostridia botulinum toxin A were found, but not in all cases. Muscle biopsies showed variable signs of neurogenic atrophy. In vitro electrophysiology studies revealed decreased end-plate potentials quantal content, confirming the presynaptic nature of the disorder. Mechanical ventilation was required in 5 patients. Half of the patients were treated with polyvalent antitoxiin. Prognosis was favorable, though recovery was slow. In conclusion, acute bulbar weakness with visual symptoms in patients with subcutaneous heroin abuse strongly suggets the possibility of wound botulism. High diagnostic suspicion combined with histology and in vitro electrophysiology confirmation of presynaptic failure, especially in seronegative cases, may significantly improve morbidity.
authors.affiliation: Neurology Department, University of California-Davis 95616, USA.
authors.forename: R A
authors.initials: RA
authors.lastname: Maselli
authors.forename: W
authors.initials: W
authors.lastname: Ellis
authors.forename: R N
authors.initials: RN
authors.lastname: Mandler
authors.forename: F
authors.initials: F
authors.lastname: Sheikh
authors.forename: G
authors.initials: G
authors.lastname: Senton
authors.forename: S
authors.initials: S
authors.lastname: Knox
authors.forename: H
authors.initials: H
authors.lastname: Salari-Namin
authors.forename: M
authors.initials: M
authors.lastname: Agius
authors.forename: R L
authors.initials: RL
authors.lastname: Wollmann
authors.forename: D P
authors.initials: DP
authors.lastname: Richman
mesh_terms: D000328:Adult; D001906:Botulism / Q000473:pathology* / Q000503:physiopathology* / Q000628:therapy; D016000:Cluster Analysis; D004594:Electrophysiology; D005071:Evoked Potentials; D005260:Female; D006760:Hospitalization; D006801:Humans; D008297:Male; D008839:Microelectrodes; D008854:Microscopy, Electron; D008875:Middle Aged; D009045:Motor Endplate / Q000503:physiopathology; D016896:Treatment Outcome; D014947:Wounds and Injuries / Q000382:microbiology*