title: Arylamine N-acetyltransferase (NAT2) genotypes in a Turkish population.
abstract: A group of 303 unrelated Turkish subjects from south-east Anatolia was genotyped for seven NAT2 mutations by polymerase chain reaction-restriction fragment length polymorphism. Genotypes associated with slow acetylation were identified in 57.4% (95%-confidence limits, 51.6%-63.1%). Allele frequencies were NAT2*4 (wild type, 23.1%), *5A (1.3%), *5B (35.6%), *5C (4.8%), *6A (30.5%), *7B (4.5%), and *12A (0.2%). A mutation G191A was not detected. Ambiguous mutation linkages were checked by molecular genetic linkage analysis and DNA sequencing. NAT2-alleles in Turks are similarly distributed as in Middle European ethnicities.
authors.affiliation: Institute of Clinical Pharmacology, University Clinic Charité, Humboldt University of Berlin, Germany.
authors.forename: A S
authors.initials: AS
authors.lastname: Aynacioglu
authors.forename: I
authors.initials: I
authors.lastname: Cascorbi
authors.forename: P M
authors.initials: PM
authors.lastname: Mrozikiewicz
authors.forename: I
authors.initials: I
authors.lastname: Roots
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D001191:Arylamine N-Acetyltransferase / Q000235:genetics*; D002648:Child; D004252:DNA Mutational Analysis; D005260:Female; D005787:Gene Frequency; D008040:Genetic Linkage; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D017354:Point Mutation; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D014421:Turkey
chemical_list: D001191:Arylamine N-Acetyltransferase