Long-term effects of intrauterine growth retardation.
Intrauterine growth retardation (IUGR) was studied both after experimental induction in rats and spontaneously occurring in man. The growth-retarded rat pups were compared to appropriately grown litter mates with developmental and behavioural tests at 50 and 90 days of age. Female rats exhibited no differences between growth-retarded and control rats but growth-retarded male rats had poor performance at 50 but not at 90 days compared to male controls. In the patient study 25 growth-retarded babies were compared with 21 appropriately grown controls. The growth-retarded babies had delayed latency periods of the visual evoked potentials at term and 6 weeks later, and at follow-up (18 months) demonstrated significantly more developmental and behavioural problems than the control group.
Kjellmer
I
I
Department of Paediatrics, University of Göteborg, Sweden.
Liedholm
M
M
Sultan
B
B
Wennergren
M
M
Wallin Götborg
C
C
Thordstein
M
M
D000818:Animals; D000831:Animals, Newborn; D002658:Developmental Disabilities / Q000209:etiology; D005074:Evoked Potentials, Visual; D005260:Female; D005317:Fetal Growth Retardation / Q000150:complications*; D006801:Humans; D007231:Infant, Newborn / Q000502:physiology* / Q000523:psychology; D007236:Infant, Small for Gestational Age / Q000502:physiology* / Q000523:psychology; D008297:Male; D051381:Rats; D012737:Sex Factors