title: Supratentorial parenchyma in the developing fetal brain: in vitro MR study with histologic comparison.
abstract: OBJECTIVE
  To assess the in vitro MR signal of the developing brain through histologic comparisons.
  
  
  METHODS
  Five healthy fetal specimens aged 16, 19, 22, 27, and 34 gestational weeks were studied in vitro using T1- and T2-weighted sequences in frontal and axial planes. Neuropathologic studies included sections in the same frontal plane. Comparison of histologic sections with measurements of the relative widths of the layers of different signal intensities enabled us to assign cellular correspondence to each MR layer.
  
  
  RESULTS
  In the cerebral mantle, a layered pattern was observed on both T1- and T2-weighted images. In the basal ganglia, signal from the pallidum and thalamus was isointense with white matter from 16 to 22 weeks' gestation; then, from 27 and 34 weeks' gestation, the signal was relatively high on T1-weighted images and low on T2-weighted images. The neostriatum had a relatively low signal on T1-weighted images and a high signal on T2-weighted images from 16 to 27 weeks' gestation: then, at 34 weeks' gestation, the signal was relatively high on T1-weighted images and low on T2-weighted images.
  
  
  CONCLUSIONS
  MR imaging can clearly show specific patterns of growing fetal brain in vitro.
authors.affiliation: Service de Radiopédiatrie, Hôpital Robert Debré, Paris, France.
authors.forename: H
authors.initials: H
authors.lastname: Brisse
authors.forename: C
authors.initials: C
authors.lastname: Fallet
authors.forename: G
authors.initials: G
authors.lastname: Sebag
authors.forename: C
authors.initials: C
authors.lastname: Nessmann
authors.forename: P
authors.initials: P
authors.lastname: Blot
authors.forename: M
authors.initials: M
authors.lastname: Hassan
mesh_terms: D001479:Basal Ganglia / Q000196:embryology / Q000473:pathology; D001921:Brain / Q000196:embryology* / Q000473:pathology; D002540:Cerebral Cortex / Q000196:embryology / Q000473:pathology; D005260:Female; D005865:Gestational Age; D006801:Humans; D066298:In Vitro Techniques; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging; D011247:Pregnancy; D012016:Reference Values