title: Sustained response to interferon in a patient with common variable immunodeficiency and hepatitis C.
abstract: Hepatitis C infection progresses faster in patients with hypogammaglobulinemia, often leading to death from liver failure within 10 yr of exposure. Response to interferon treatment has been poor in these patients. We report the case of a patient with common variable immunodeficiency and hepatitis C in whom a sustained biochemical and viral remission was obtained after treatment with interferon.
authors.affiliation: Department of Medicine, University of Puerto Rico School of Medicine, San Juan.
authors.forename: F
authors.initials: F
authors.lastname: Castro
authors.forename: M
authors.initials: M
authors.lastname: Santaella
authors.forename: E A
authors.initials: EA
authors.lastname: Torres
authors.forename: J R
authors.initials: JR
authors.lastname: Rodriguez-Medina
authors.forename: C
authors.initials: C
authors.lastname: González-Keelan
mesh_terms: D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use*; D002423:Cause of Death; D017074:Common Variable Immunodeficiency / Q000150:complications* / Q000628:therapy; D018450:Disease Progression; D004340:Drug Contamination; D005260:Female; D016174:Hepacivirus / Q000235:genetics / Q000302:isolation & purification; D006526:Hepatitis C / Q000150:complications / Q000628:therapy*; D006521:Hepatitis, Chronic / Q000150:complications / Q000628:therapy; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000627:therapeutic use*; D017093:Liver Failure / Q000209:etiology; D011379:Prognosis; D012367:RNA, Viral / Q000032:analysis / Q000235:genetics; D011994:Recombinant Proteins
chemical_list: D000998:Antiviral Agents; D016756:Immunoglobulins, Intravenous; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D012367:RNA, Viral; D011994:Recombinant Proteins