title: Immunogenicity of an inactivated hepatitis A vaccine in Dutch United Nations troops.
abstract: Limited information existed on the immunogenicity of an inactivated hepatitis A vaccine as part of an extensive vaccination schedule. Dutch marines bound for duty in Cambodia received inactivated hepatitis A vaccine (720 ELISA units of antigen, two intra-gluteal doses at a 2-week interval before departure and an intra-deltoid booster vaccination after 8 months) simultaneously with several other vaccines. Hepatitis A antibodies were determined in blood-samples drawn before and after the booster vaccination, using two laboratory tests (modified HAVAB and SBB-ELISA). At 8 months, before the booster vaccination, 52% (modified HAVAB) and 81% (SBB-ELISA) had seroconverted. Risk factors for non-seroconversion were increasing age and a typhoid vaccination. At 11 months 97.6% (modified HAVAB) and 100% (SBB-ELISA) had seroconverted. Non-seroconversion at 8 months was remarkably high. SBB-ELISA was more sensitive in lower titre ranges.
authors.affiliation: Medical Service Royal Netherlands Navy, Hilversum, The Netherlands.
authors.forename: A P
authors.initials: AP
authors.lastname: Hopperus Buma
authors.forename: G J
authors.initials: GJ
authors.lastname: van Doornum
authors.forename: R L
authors.initials: RL
authors.lastname: Veltink
authors.forename: E J
authors.initials: EJ
authors.lastname: van Ameijden
authors.forename: A
authors.initials: A
authors.lastname: Leentvaar-Kuijpers
authors.forename: R A
authors.initials: RA
authors.lastname: Coutinho
mesh_terms: D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000097:blood; D022362:Hepatitis A Vaccines; D006507:Hepatovirus / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008889:Military Personnel; D012189:Retrospective Studies; D014611:Vaccination; D015164:Vaccines, Inactivated / Q000276:immunology; D014761:Viral Hepatitis Vaccines / Q000276:immunology*
chemical_list: D000914:Antibodies, Viral; D022362:Hepatitis A Vaccines; D015164:Vaccines, Inactivated; D014761:Viral Hepatitis Vaccines