Idiopathic myelofibrosis with neutrophil myeloperoxidase deficiency: a case report.
We describe a case of idiopathic myelofibrosis with total neutrophil myeloperoxidase deficiency. The combination of this enzymatic defect with myelofibrotic changes in the nuclear shape of neutrophils confers a peculiar appearance on leukograms produced by a Technicon H*1. The clinical course of the disease was shortened by recurrent infections that may be ascribed, at least in part, to reduced leukocyte microbicidal ability.
Caenazzo
A
A
Chair of Internal Medicine, University of Padua, Italy.
Piva
E
E
Sartori
D
D
Stefani
P M
PM
D001853:Bone Marrow / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000201:enzymology* / Q000473:pathology; D009195:Peroxidase / Q000172:deficiency*; D055728:Primary Myelofibrosis / Q000097:blood / Q000201:enzymology* / Q000473:pathology / Q000503:physiopathology
D009195:Peroxidase