Effects of lead exposure on bromocriptine-induced penile erection in rats.
In the present work we have studied the effects of lead exposure on penile erection induced by bromocriptine. Intraperitoneal injection of bromocriptine (2, 3, 4 and 8 mg/kg) induced dose-related penile erection in rats. Maximum response was observed with 4 mg/kg of the drug. Lead exposure (as Pb-acetate in drinking water) for periods of 7, 14, 21 and 28 days decreased the bromocriptine-induced penile erection response. Higher concentrations of lead (0.05%) were shown to cause a more prominent decrease of penile erection. The same procedure for lead administration did not significantly alter penile erection induced by physostigmine (0.1 and 0.3 mg/kg, intraperitoneally). In a series of experiments, blood lead concentrations were measured 7 and 21 days after lead exposure. Significant increases of lead concentrations were found after lead exposure. It is concluded that lead can influence bromocriptine-induced penile erection.
Ghazi-Khansari
M
M
Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Iran.
Heidari
I
I
Zarrindast
M R
MR
D000818:Animals; D001971:Bromocriptine / Q000494:pharmacology; D018491:Dopamine Agonists / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005618:Fresh Water; D007274:Injections, Intraperitoneal; D007854:Lead / Q000097:blood; D008297:Male; D009942:Organometallic Compounds / Q000008:administration & dosage / Q000633:toxicity*; D010277:Parasympathomimetics / Q000494:pharmacology; D010410:Penile Erection / Q000187:drug effects*; D010830:Physostigmine / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013054:Spectrophotometry, Atomic
D018491:Dopamine Agonists; D009942:Organometallic Compounds; D010277:Parasympathomimetics; D007854:Lead; D001971:Bromocriptine; D010830:Physostigmine; C008261:lead acetate