title: Plasma interleukin-1 beta and sleep architecture in schizophrenia and other nonaffective psychoses.
abstract: OBJECTIVE
  It has been reported that sleep deprivation may enhance interleukin (IL)-1 beta production of healthy subjects. Furthermore, patients with acute psychoses have been reported to exhibit higher levels of IL-1 beta than healthy controls. The present study examined polysomnographic sleep and morning IL-1 beta plasma values in 20 drug-free patients with acute nonaffective psychoses.
  
  
  METHODS
  Ten patients with DSM-III diagnosis of schizophrenia, five with delusional disorder, and five with atypical psychosis underwent polysomnographic sleep registrations and their morning blood levels of IL-1 beta were measured.
  
  
  RESULTS
  IL-1 beta values correlated negatively with the length of the sleep period (p = 0.010) and the relative time of rapid eye movement (REM) sleep (p = 0.038), and positively with REM latency (p = 0.043).
  
  
  CONCLUSIONS
  It is concluded that reduced sleep, possibly especially reduced REM sleep, may be a reason for increased morning IL-1 beta values in these patients. Additional studies on IL-1 beta in psychiatric patients should consider the possibility of sleep disturbances as a possible explanation for deviations in IL-1 beta levels.
authors.affiliation: Department of Psychiatry, Helsinki University Central Hospital, Finland.
authors.forename: B
authors.initials: B
authors.lastname: Appelberg
authors.forename: H
authors.initials: H
authors.lastname: Katila
authors.forename: R
authors.initials: R
authors.lastname: Rimon
mesh_terms: D000293:Adolescent; D000328:Adult; D003430:Cross-Sectional Studies; D006801:Humans; D007375:Interleukin-1 / Q000097:blood*; D008875:Middle Aged; D017286:Polysomnography; D011618:Psychotic Disorders / Q000503:physiopathology*; D012559:Schizophrenia / Q000503:physiopathology*; D012890:Sleep / Q000502:physiology*; D012892:Sleep Deprivation / Q000502:physiology; D012895:Sleep, REM / Q000502:physiology
chemical_list: D007375:Interleukin-1