title: BCL-2 oncoprotein (p26) in splenic lymphoma with villous lymphocytes: a comparative study with other chronic B-cell disorders.
abstract: We compared the expression of the BCL-2 oncoprotein (p26) on B cells from 24 patients with splenic lymphoma with circulating villous lymphocytes (SLVL) with that observed on normal, mature B lymphocytes and on neoplastic B cells from 91 patients with other chronic B-cell malignancies. SLVL B cells showed levels of p26 intermediate between those found on normal B lymphocytes and on neoplastic B cells from patients with other chronic B-cell lymphoproliferative disorders.
authors.affiliation: Service of Clinical Hematology, S. Antonio's Hospital, Porto, Portugal.
authors.forename: M
authors.initials: M
authors.lastname: Lima
authors.forename: M
authors.initials: M
authors.lastname: dos Anjos Teixeira
authors.forename: M L
authors.initials: ML
authors.lastname: Queirós
authors.forename: A H
authors.initials: AH
authors.lastname: Ribeiro dos Santos
authors.forename: B
authors.initials: B
authors.lastname: Justiça
mesh_terms: D001402:B-Lymphocytes / Q000378:metabolism; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000378:metabolism*; D015463:Leukemia, Prolymphocytic / Q000378:metabolism; D008223:Lymphoma / Q000378:metabolism*; D008232:Lymphoproliferative Disorders / Q000378:metabolism*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism*; D012016:Reference Values; D013160:Splenic Neoplasms / Q000378:metabolism*
chemical_list: D019253:Proto-Oncogene Proteins c-bcl-2