Inhibition of elicitation of contact dermatitis in humans by mometasone furoate: evaluation by means of 20-MHz B scanning associated with image analysis.
BACKGROUND
Mometasone furoate (MF) is a new strongly lipophilic steroid which has an anti-inflammatory effect as evaluated by in vivo and in vitro studies.


OBJECTIVE
The objective of the present study was to investigate the degree of inhibition of experimental allergic contact dermatitis induced by the treatment with MF.


METHODS
The therapeutic effect was evaluated by an echographic method associated with image analysis. MF activity was compared to that of hydrocortisone acetate 0.5% (Cortaid Cream, Lachifarma), clobetasone butyrate 0.05% (Eumovate Cream, Glaxo) and clobetasol propionate 0.05% (Clobesol Cream, Glaxo), classified respectively as weak, moderately potent and very potent steroids.


RESULTS
The different corticosteroid formulations employed for inhibiting experimentally induced contact dermatitis reflect the expected rank order of efficacy.


CONCLUSIONS
MF behaves like clobetasol butyrate ranking as a moderately potent corticosteroid.
Di Nardo
A
A
Department of Dermatology, University of Modena, Italy.
Giusti
G
G
Mantovani
L
L
Bianchi
B
B
Seidenari
S
S
D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D002990:Clobetasol / Q000008:administration & dosage / Q000031:analogs & derivatives; D017449:Dermatitis, Allergic Contact / Q000000981:diagnostic imaging* / Q000517:prevention & control*; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000008:administration & dosage; D007089:Image Enhancement / Q000379:methods*; D008875:Middle Aged; D000068656:Mometasone Furoate; D010328:Patch Tests; D011244:Pregnadienediols / Q000008:administration & dosage*; D015203:Reproducibility of Results; D012867:Skin / Q000187:drug effects / Q000473:pathology; D014463:Ultrasonography
D000893:Anti-Inflammatory Agents; D011244:Pregnadienediols; D000068656:Mometasone Furoate; C010893:clobetasone butyrate; D002990:Clobetasol; D006854:Hydrocortisone