Cerebrospinal fluid apo E and apo A-I concentrations in early- and late-onset Alzheimer's disease.
We compared cerebrospinal fluid (CSF) apolipoprotein (apo) A-I and apo E concentrations in early- and late-onset Alzheimer's disease (EOAD (n = 11), LOAD (n = 15), respectively) with those in control subjects (n = 23). CSF apo A-I levels in both EOAD and LOAD were consistent with control subjects. However, CSF apo E levels were significantly lower in EOAD group (mean +/- SD; 2.65 +/- 1.69 mg/l, P < 0.05) and higher in LOAD group (5.90 +/- 1.94 mg/l, P < 0.01) than those in control group (4.16 +/- 1.69 mg/l). In addition, the epsilon4 allele frequency was not different between EOAD and LOAD groups. Although the reason for the difference in CSF apo E concentrations between two groups is unknown, CSF apo E concentration seems to be associated with the pathogenesis of EOAD and LOAD. The rate of apo E production and/or catabolism in the brain may be different between them.
Song
H
H
Department of Laboratory Medicine, Gifu University School of Medicine, Japan.
Saito
K
K
Seishima
M
M
Noma
A
A
Urakami
K
K
Nakashima
K
K
D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D000544:Alzheimer Disease / Q000134:cerebrospinal fluid* / Q000235:genetics; D016632:Apolipoprotein A-I / Q000134:cerebrospinal fluid*; D001057:Apolipoproteins E / Q000134:cerebrospinal fluid* / Q000235:genetics; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged
D016632:Apolipoprotein A-I; D001057:Apolipoproteins E