title: [Rokitamycin tolerance in patients with adverse reactions to chemotherapeutic agents].
abstract: The main task in the drug intolerance reactions is the choice of "alternative" drug by oral challenge. The tolerance of rokitamycine (RKM), a new macrolide with a wide activity spectrum in 133 antibiotic-intolerant patients has been studied by open oral challenge with incremental dosage until a cumulative dose of 406 mg. The RKM in 96.2% of cases has been well tolerated. Only 5 patients (3.8%) have had reactions, mainly "atypical" and of minor clinical importance, at cumulative doses ranging from 31.25 to 250 mg. The RKM has been well tolerated also by 6 patients who have had reactions to macrolides belonging to the same group (16 membered). Finally, the use of RKM as alternative drug in chemotherapeutics-intolerant patients has been proposed.
authors.affiliation: Cattedra di Allergologia ed Immunologia Clinica, Università degli Studi di Bari.
authors.forename: L
authors.initials: L
authors.lastname: Cenci
authors.forename: E
authors.initials: E
authors.lastname: Nettis
authors.forename: R
authors.initials: R
authors.lastname: Berteramo
authors.forename: A
authors.initials: A
authors.lastname: Ferrannini
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects*; D002648:Child; D004305:Dose-Response Relationship, Drug; D004341:Drug Evaluation; D004361:Drug Tolerance; D064420:Drug-Related Side Effects and Adverse Reactions; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015644:Miocamycin / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*
chemical_list: D000900:Anti-Bacterial Agents; D015644:Miocamycin; C033383:rokitamycin