Effect of methamphetamine on tryptophan hydroxylase activity: role of hyperthermia.
A single administration of methamphetamine (15 mg/kg, s.c.) decreased activity of the 5-hydroxytryptamine (5-HT)-synthesizing enzyme, tryptophan hydroxylase, in rat striatum 1 h after administration. Methamphetamine also increased core body temperatures by greater than 3 degrees C in these rats. Prevention of hyperthermia attenuated the methamphetamine-induced decrease in tryptophan hydroxylase activity. Core temperature at the time of injection (from 37.7 degrees C to 40 degrees C) did not influence the magnitude of this decrease. Moreover, augmenting, methamphetamine-induced hyperthermia (from approximately 41 to 42 degrees C) did not cause a further decrease in tryptophan hydroxylase activity. These data indicate that temperature contributes to, but is not solely responsible for, methamphetamine-induced 5-HT neuronal impairment.
Fleckenstein
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Department of Pharmacology and Toxicology, University of Utah, Salt Lake City 84112, USA.
D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D003342:Corpus Striatum / Q000187:drug effects / Q000201:enzymology*; D005334:Fever / Q000378:metabolism / Q000503:physiopathology* / Q000517:prevention & control; D008297:Male; D008694:Methamphetamine / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014365:Tryptophan Hydroxylase / Q000378:metabolism*
D008694:Methamphetamine; D014365:Tryptophan Hydroxylase