title: Effects of entorhinal cortex lesions on memory in different tasks.
abstract: Lesions of the entorhinal cortex produce retrograde memory impairment in both animals and humans. Here we report the effects of bilateral entorhinal cortex lesions caused by the stereotaxic infusion of N-methyl-D-aspartate (NMDA) in rats at two different moments, before or after the training session, on memory of different tasks: two-way shuttle avoidance, inhibitory avoidance and habituation to an open field. Pre- or post-training entorhinal cortex lesions caused an impairment of performance in the shuttle avoidance task, which agrees with the previously described role of this area in the processing of memories acquired in successive sessions. In the inhibitory avoidance task, only the post-training lesions had an effect (amnesia). No effect was observed on the open field task. The findings suggest that the role of the entorhinal cortex in memory processing is task-dependent, perhaps related to the complexity of each task.
authors.affiliation: Departamento de Bioquímica, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brasil.
authors.forename: G P
authors.initials: GP
authors.lastname: Gutierrez-Figueroa
authors.forename: C
authors.initials: C
authors.lastname: Dalmaz
authors.forename: I
authors.initials: I
authors.lastname: Izquierdo
mesh_terms: D000544:Alzheimer Disease / Q000209:etiology; D000818:Animals; D001362:Avoidance Learning; D001522:Behavior, Animal / Q000502:physiology*; D018728:Entorhinal Cortex / Q000473:pathology*; D018683:Excitatory Amino Acid Agents / Q000494:pharmacology*; D008297:Male; D018782:Maze Learning; D008569:Memory Disorders / Q000209:etiology*; D016202:N-Methylaspartate / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013238:Stereotaxic Techniques
chemical_list: D018683:Excitatory Amino Acid Agents; D016202:N-Methylaspartate