title: A newly recognized cause of wheezing: AIDS-related bronchial leiomyomas.
abstract: We present two human immunodeficiency virus-infected children who developed wheezing and radiological evidence of pulmonary air trapping due to intra- and peribronchial leiomyomas. At autopsy, leiomyomas were also found in their spleens, which to our knowledge, has never been reported. The smooth muscle tumors were strongly positive for the Epstein-Barr virus, as demonstrated by in situ hybridization to Epstein-Barr virus-encoded ribonucleic acid, confirming the findings of recent investigators and linking these tumors to the Epstein-Barr virus.
authors.affiliation: Department of Pathology, St. Christopher's Hospital for Children, Philadelphia, Pennsylvania 19134-1095, USA.
authors.forename: J P
authors.initials: JP
authors.lastname: de Chadarévian
authors.forename: J H
authors.initials: JH
authors.lastname: Wolk
authors.forename: S
authors.initials: S
authors.lastname: Inniss
authors.forename: H W
authors.initials: HW
authors.lastname: Lischner
authors.forename: F
authors.initials: F
authors.lastname: d'Amore
authors.forename: E N
authors.initials: EN
authors.lastname: Faerber
authors.forename: G C
authors.initials: GC
authors.lastname: Isaacson
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D001984:Bronchial Neoplasms / Q000209:etiology* / Q000517:prevention & control / Q000821:virology; D002648:Child; D002675:Child, Preschool; D017809:Fatal Outcome; D004854:Herpesvirus 4, Human / Q000302:isolation & purification; D006801:Humans; D007889:Leiomyoma / Q000209:etiology* / Q000473:pathology / Q000821:virology; D008297:Male; D012135:Respiratory Sounds / Q000209:etiology*