Spirulina platensis inhibits anaphylactic reaction.
We investigated the effects of the powders of Spirulina platensis (SPP) on anaphylactic reactions. SPP inhibited compound 48/80-induced anaphylactic shock 100% with doses of 0.5, and 1.0 mg/g body weight (BW). SPP significantly inhibited serum histamine levels induced by compound 48/80 in rats. SPP (0.5 mg/g BW) inhibited to 68.7% passive cutaneous anaphylaxis activated by anti-dinitrophenyl (DNP) IgE. SPP dose-dependently inhibited the histamine release from the rat peritoneal mast cells (RPMC) by compound 48/80. Moreover, SPP had a significant effect on anti-DNP IgE-induced histamine release or tumor necrosis factor-alpha production from RPMC. These results suggest that SPP may contain compounds with actions that inhibit mast cell degranulation in the rat.
Yang
H N
HN
Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University, Ikasn, Chonbuk, South Korea.
Lee
E H
EH
Kim
H M
HM
D000818:Animals; D015550:Cell Degranulation; D000458:Cyanobacteria / Q000502:physiology*; D004140:Dinitrophenols / Q000276:immunology; D006632:Histamine / Q000097:blood; D006636:Histamine Release / Q000276:immunology; D007073:Immunoglobulin E / Q000276:immunology; D010323:Passive Cutaneous Anaphylaxis / Q000276:immunology; D051381:Rats; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis; D003189:p-Methoxy-N-methylphenethylamine
D004140:Dinitrophenols; D014409:Tumor Necrosis Factor-alpha; D007073:Immunoglobulin E; D003189:p-Methoxy-N-methylphenethylamine; D006632:Histamine