The critical role of nucleus accumbens dopamine systems in the mediation of fixed interval schedule-controlled operant behavior.
Microinjections of the irreversible dopamine antagonist EEDQ (N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline), into nucleus accumbens but not into dorsal striatum, markedly decreased response rates on a fixed interval schedule of reinforcement. These preferential effects in nucleus accumbens could be prevented by selectively activating either D1 or D2 receptors. These data demonstrate a critical role for mesolimbic dopamine systems in the mediation of fixed interval schedule-controlled operant behavior.
Cory-Slechta
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DA
Department of Neurobiology and Anatomy, University of Rochester Medical School, NY 14642, USA. slechta@envmed.rochester.edu
Pazmino
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Bare
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D000818:Animals; D003216:Conditioning, Operant / Q000502:physiology*; D004298:Dopamine / Q000502:physiology*; D018492:Dopamine Antagonists / Q000494:pharmacology; D008297:Male; D008845:Microinjections; D009714:Nucleus Accumbens / Q000502:physiology*; D011804:Quinolines / Q000494:pharmacology; D051381:Rats; D017447:Receptors, Dopamine D1 / Q000819:agonists; D017448:Receptors, Dopamine D2 / Q000819:agonists; D012055:Reinforcement Schedule
D018492:Dopamine Antagonists; D011804:Quinolines; D017447:Receptors, Dopamine D1; D017448:Receptors, Dopamine D2; C000470:EEDQ; D004298:Dopamine