[Evaluation of myocardial protection with DBcAMP in crystalloid cardioplegic solutions].
The potential for myocardial protection during cardiac operation was evaluated by adding Dibutyryl cyclic AMP (DBcAMP) to the crystalloid cardioplegic solutions. We have compared the cold crystalloid cardioplegia with DBcAMP (Group D n = 15) and without DBcAMP (Group n = 20) in patients undergoing cardiac operation. In hemodynamics, both groups were no difference before and after operation. CPK and CPK-MB was significantly (p < 0.01) high level after cardiopulmonary bypass (CPB) in group C. Myoglobin was also high value after CBP in group C, but not significant. Myocardial oxygen extraction rate and coronary blood PCO2 release were similar change in both groups. Insulin/glucose ratio was high level during and after CBP in group D. Myocardial lactate/pyruvate ratio was very high level after CBP in group C without significant difference. We consider that the cardioplegic solution with DBcAMP is effectual for the myocardial metabolism and preservation of myocardial damage during cardiac arrest.
Ishikura
Y
Y
Odagiri
S
S
Shimazu
A
A
Tokunaga
H
H
Shimokawaji
M
M
Yoshimatsu
H
H
D000328:Adult; D000368:Aged; D003994:Bucladesine / Q000008:administration & dosage*; D006348:Cardiac Surgical Procedures; D005260:Female; D006324:Heart Arrest, Induced; D006331:Heart Diseases / Q000503:physiopathology / Q000601:surgery; D006439:Hemodynamics; D006801:Humans; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism; D010101:Oxygen Consumption; D017680:Potassium Compounds
D017680:Potassium Compounds; C018369:potassium cardioplegic solution; D003994:Bucladesine