Pharmacokinetic profile of cefaclor.
Cefaclor is a well-absorbed oral cephalosporin antibiotic. Peak concentrations in serum are attained within 30-60 minutes. Food intake reduces the rate, but not the extent of absorption. Cefaclor is not metabolized to a significant degree, but it degrades chemically in the body with an approximate half-life of 2 hours. Most of the drug is excreted unchanged in the urine, the serum half-life after oral administration is 0.5-0.7 hours. Due to the chemical degradation, cefaclor does not accumulate to the same degree as other cephalosporins in case of renal impairment.
Sourgens
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College of Pharmacy, University of Florida, Gainesville, USA.
Derendorf
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Schifferer
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D000368:Aged; D000863:Antacids / Q000494:pharmacology; D019540:Area Under Curve; D002433:Cefaclor / Q000378:metabolism / Q000493:pharmacokinetics*; D002511:Cephalosporins / Q000493:pharmacokinetics*; D002648:Child; D002927:Cimetidine / Q000494:pharmacology; D004347:Drug Interactions; D006207:Half-Life; D006801:Humans; D007223:Infant; D051437:Renal Insufficiency / Q000378:metabolism; D013806:Theophylline / Q000494:pharmacology
D000863:Antacids; D002511:Cephalosporins; D002433:Cefaclor; D002927:Cimetidine; D013806:Theophylline