title: Synthesis, cytotoxicity and SAR of simple geiparvarin analogues.
abstract: Some simple geiparvarin analogues, in which the coumarin moiety has been replaced with an X-substituted benzene ring, are described. The compounds were tested on LoVo cells (human colon carcinoma cell line) and some of them show a cytotoxicity comparable with that of the prototype. A QSAR analysis was also attempted, but it did not provide satisfactory results, mainly because of the limited range of variation of the biological activity.
authors.affiliation: Department of Pharmaceutical Sciences, University of Bologna, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Valenti
authors.forename: A
authors.initials: A
authors.lastname: Rampa
authors.forename: M
authors.initials: M
authors.lastname: Recanatini
authors.forename: A
authors.initials: A
authors.lastname: Bisi
authors.forename: F
authors.initials: F
authors.lastname: Belluti
authors.forename: P
authors.initials: P
authors.lastname: Da Re
authors.forename: M
authors.initials: M
authors.lastname: Carrara
authors.forename: L
authors.initials: L
authors.lastname: Cima
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D003110:Colonic Neoplasms / Q000473:pathology; D003374:Coumarins / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D003374:Coumarins; C058446:geiparvarin