title: Monocarboxylates (pyruvate and lactate) as alternative energy substrates for the induction of long-term potentiation in rat hippocampal slices.
abstract: We previously reported that mild hypoglycemic conditions hamper the induction of long-term potentiation (LTP) in the CA1 region of rat hippocampal slices. In the present study, we examined whether monocarboxylates (pyruvate and lactate) permit LTP induction when glucose is unavailable. During glucose deprivation, pyruvate and lactate not only maintained basal synaptic transmission but also allowed LTP induction, with pyruvate being more effective than lactate. Additionally, LTP inhibition by 5 microM iodoacetate, a glycolytic inhibitor, was prevented by addition of pyruvate but not lactate. These results suggest that monocarboxylates can be affected alternative energy substrates for LTP induction when glucose is not available. However, lactate and pyruvate are not identical as energy sources for LTP induction.
authors.affiliation: Department of Psychiatry, Washington University, School of Medicine, St. Louis, MO 63110, USA. izumiy@psychiatry.wustl.edu
authors.forename: Y
authors.initials: Y
authors.lastname: Izumi
authors.forename: H
authors.initials: H
authors.lastname: Katsuki
authors.forename: C F
authors.initials: CF
authors.lastname: Zorumski
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D004594:Electrophysiology; D004734:Energy Metabolism / Q000187:drug effects* / Q000502:physiology; D005947:Glucose / Q000378:metabolism; D006624:Hippocampus / Q000378:metabolism*; D007461:Iodoacetates; D019807:Iodoacetic Acid; D007773:Lactates / Q000378:metabolism / Q000494:pharmacology*; D017774:Long-Term Potentiation / Q000187:drug effects / Q000502:physiology*; D009924:Organ Culture Techniques; D019289:Pyruvic Acid / Q000378:metabolism / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D007461:Iodoacetates; D007773:Lactates; D019289:Pyruvic Acid; D005947:Glucose; D019807:Iodoacetic Acid