TMC-2A, -2B and -2C, new dipeptidyl peptidase IV inhibitors produced by Aspergillus oryzae A374. II. Isolation and structure determination.
New dipeptidyl peptidase IV inhibitors, TMC-2A, -2B, and -2C, were isolated from the fermentation broth of Aspergillus oryzae A374. On the basis of chemical, spectroscopic and X-ray crystallographic analyses, their structures were established to be peptide-like compounds composed of three moieties, L-tryptophan, mono- or dihydroxy-L-leucine and highly substituted isoquinoline.
Asai
Y
Y
Lead Generation Research Laboratory at Toda, Tanabe Seiyaku Co., Ltd., Saitama, Japan.
Nonaka
N
N
Nishio
M
M
Okamura
K
K
Date
T
T
Sugita
T
T
Ohnuki
T
T
Komatsubara
S
S
D000596:Amino Acids / Q000032:analysis; D018360:Crystallography, X-Ray; D004152:Dipeptidyl-Peptidases and Tripeptidyl-Peptidases / Q000037:antagonists & inhibitors; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D005285:Fermentation; D007211:Indoles / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D007546:Isoquinolines / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D015394:Molecular Structure
D000596:Amino Acids; D004791:Enzyme Inhibitors; D007211:Indoles; D007546:Isoquinolines; C108548:TMC 2A; C108549:TMC 2B; C108550:TMC 2C; D004152:Dipeptidyl-Peptidases and Tripeptidyl-Peptidases