Mannan-binding lectin serum concentrations in HIV-infected patients are influenced by the stage of disease.
Serum concentrations of mannan-binding lectin (MBL) were determined in the sera of 67 HIV-seropositive patients in different stages of HIV disease and in the sera of 75 HIV-seronegative healthy individuals. In the asymptomatic (AS) HIV-infected persons MBL concentrations were found to be significantly (P < 0.05) lower than in the HIV-seronegative controls, whereas in the AIDS patients they were not. Very low (< or = 25 ng/ml) MBL serum concentrations were detected in 5/19 (26.3%) and 7/75 (9.3%) of the AS HIV-seropositive and HIV-seronegative individuals, respectively (P = 0.06). In the sera of the HIV-infected patients, MBL levels positively correlated to the neopterin concentrations (Spearman correlation coefficient, 0.401, P = 0.0009) while they negatively correlated to the percentage (-0.447, P = 0.0011) and absolute number (-0.453, P = 0.0012) of the CD4+ lymphocytes. These observations indicate that MBL level, which is under strict genetic control, may influence the susceptibility to HIV infection and the progression of HIV disease.
Prohászka
Z
Z
3rd Department of Medicine, Semmelweis Medical University, Budapest, Hungary.
Thiel
S
S
Ujhelyi
E
E
Szlávik
J
J
Bánhegyi
D
D
Füst
G
G
D001798:Blood Proteins / Q000378:metabolism*; D015496:CD4-Positive T-Lymphocytes; D002352:Carrier Proteins / Q000097:blood*; D037222:Collectins; D018450:Disease Progression; D015658:HIV Infections / Q000097:blood* / Q000276:immunology; D006801:Humans; D037102:Lectins / Q000097:blood*; D008351:Mannans / Q000097:blood*; D019798:Neopterin / Q000097:blood; D016176:T-Lymphocyte Subsets
D001798:Blood Proteins; D002352:Carrier Proteins; D037222:Collectins; D037102:Lectins; D008351:Mannans; D019798:Neopterin