title: Genomic diversity in the pfoA region of the theta-toxin-deficient strains of Clostridium perfringens.
abstract: The genomic structure of the pfoA-colA region in six theta-toxin-deficient strains of Clostridium perfringens was examined by Southern hybridization using the pfoR, pfoA, pbg, arcABDC and colA genes, encoding regulator for pfoA, theta-toxin, beta-galactosidase, arginine metabolism enzymes and kappa-toxin, respectively, as gene probes. It is suggested that the productivity of theta-toxin in these strains is diverse because of the multiple genetic backgrounds including single deletion of pfoA, large deletion of the pfoA-colA region and the putative point mutations.
authors.affiliation: Department of Microbiology, University of Tsukuba, Ibaraki, Japan.
authors.forename: W
authors.initials: W
authors.lastname: Ba-Thein
authors.forename: S
authors.initials: S
authors.lastname: Inui
authors.forename: T
authors.initials: T
authors.lastname: Shimizu
authors.forename: T
authors.initials: T
authors.lastname: Swe
authors.forename: S
authors.initials: S
authors.lastname: Banu
authors.forename: K
authors.initials: K
authors.lastname: Ohtani
authors.forename: M
authors.initials: M
authors.lastname: Oe
authors.forename: N
authors.initials: N
authors.lastname: Sakurai
authors.forename: S
authors.initials: S
authors.lastname: Nakamura
authors.forename: H
authors.initials: H
authors.lastname: Hayashi
mesh_terms: D001427:Bacterial Toxins / Q000235:genetics*; D003016:Clostridium perfringens / Q000235:genetics*; D014644:Genetic Variation
chemical_list: D001427:Bacterial Toxins