The development of subretinal microphotodiodes for replacement of degenerated photoreceptors.
There are presently several concepts to restore vision in blind or highly visually handicapped persons by implanting electronic devices into the eye in order to partially restore vision. Here, the approach to replace retinal photoreceptors by a subretinally implanted microphotodiode array (MPDA) is summarized. A survey is given on the present state of the development of MPDAs, the possibility of in vitro and in vivo tests as well as first results on biocompatibility and histology. Additionally, electrophysiological recordings in rabbits and rats are presented which have received such subretinal implants.
Zrenner
E
E
University Eye Hospital, Department II, Tübingen, Germany. ezrenner@uni-tuebingen.de
Miliczek
K D
KD
Gabel
V P
VP
Graf
H G
HG
Guenther
E
E
Haemmerle
H
H
Hoefflinger
B
B
Kohler
K
K
Nisch
W
W
Schubert
M
M
Stett
A
A
Weiss
S
S
D000818:Animals; D001672:Biocompatible Materials; D004596:Electroretinography; D005137:Eye, Artificial; D006801:Humans; D008839:Microelectrodes; D010786:Photoreceptor Cells / Q000503:physiopathology*; D019736:Prostheses and Implants; D019919:Prosthesis Implantation; D011817:Rabbits; D051381:Rats; D012162:Retinal Degeneration / Q000503:physiopathology / Q000534:rehabilitation*
D001672:Biocompatible Materials