The magnitude of inotropic reserve is unrelated to basal systolic function or wall thickness in patients with chronic ischemic left ventricular dysfunction.
Forty-four patients with coronary artery disease and left ventricular dysfunction underwent transesophageal echocardiography with dobutamine infusion to investigate the relation between basal contractile function and inotropic reserve. No significant relation was observed between basal percent systolic thickening or diastolic thickness and the maximum increase in contractile function in response to dobutamine, thus emphasizing the heterogenity of the mechanisms by which coronary stenoses may affect contraction at rest and inotropic reserve in these patients.
Curiel
R V
RV
Cardiology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.
Laurienzo
J M
JM
Unger
E F
EF
Panza
J A
JA
D000368:Aged; D002316:Cardiotonic Agents / Q000494:pharmacology*; D002908:Chronic Disease; D003327:Coronary Disease / Q000150:complications / Q000503:physiopathology*; D004280:Dobutamine / Q000494:pharmacology*; D017548:Echocardiography, Transesophageal; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction / Q000187:drug effects*; D009206:Myocardium / Q000473:pathology*; D013599:Systole; D018487:Ventricular Dysfunction, Left / Q000150:complications / Q000503:physiopathology*
D002316:Cardiotonic Agents; D004280:Dobutamine