title: Involvement of TNF-alpha secreting macrophages in lethal forms of human graft-versus-host disease.
abstract: We report three patients with lethal forms of acute GVHD in whom all biopsy specimens showed a striking preponderance of macrophages in the inflammatory infiltrate with production of TNF-alpha. The role of the macrophage/TNF-alpha axis in human acute GVHD is examined and the existence of primary macrophagic forms of GVHD is discussed.
authors.affiliation: Unité Régionale de Greffe de Moelle Osseuse, CHRU Lille, France.
authors.forename: T
authors.initials: T
authors.lastname: Facon
authors.forename: J P
authors.initials: JP
authors.lastname: Jouet
authors.forename: M P
authors.initials: MP
authors.lastname: Noel-Walter
authors.forename: F
authors.initials: F
authors.lastname: Bloget
authors.forename: F
authors.initials: F
authors.lastname: Bauters
authors.forename: A
authors.initials: A
authors.lastname: Janin
mesh_terms: D000328:Adult; D016026:Bone Marrow Transplantation; D002648:Child; D017809:Fatal Outcome; D005260:Female; D006086:Graft vs Host Disease / Q000276:immunology / Q000473:pathology*; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000276:immunology / Q000473:pathology / Q000628:therapy; D015470:Leukemia, Myeloid, Acute / Q000276:immunology / Q000473:pathology / Q000628:therapy; D008264:Macrophages / Q000378:metabolism* / Q000502:physiology; D008875:Middle Aged; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism* / Q000502:physiology
chemical_list: D014409:Tumor Necrosis Factor-alpha