Closure of a ventricular septal defect in a patient with von Willebrand disease.
Few reports of open heart surgery being performed in patients with von Willebrand disease (vWD) have been documented. We describe herein the case of a 5-year-old girl with a ventricular septal defect (VSD) and vWD who underwent patch closure under cardiopulmonary bypass (CPB). The hematological parameters relating to vWD, namely, factor VIII, von Willebrand factor, and factor VIII-related antigen were monitored perioperatively. These laboratory findings were elevated after the termination of CPB, and consistently maintained within the normal range for 4 months postoperatively. The operation was successfully completed without the administration of factor VIII concentrates or homologous blood products.
Tatebe
S
S
Department of Thoracic and Cardiovascular Surgery, Niigata City General Hospital, Japan.
Kanazawa
H
H
Yamazaki
Y
Y
Aoki
E
E
Sakurai
Y
Y
Miyamura
H
H
D002315:Cardiopulmonary Bypass; D002675:Child, Preschool; D005169:Factor VIII / Q000032:analysis; D005260:Female; D006345:Heart Septal Defects, Ventricular / Q000150:complications* / Q000601:surgery*; D006801:Humans; D014842:von Willebrand Diseases / Q000097:blood / Q000150:complications*; D014841:von Willebrand Factor / Q000032:analysis
D014841:von Willebrand Factor; D005169:Factor VIII