Fatal pulmonary infection caused by the basidiomycete Hormographiella aspergillata.
A fatal case of a pulmonary infection caused by Hormographiella aspergillata, the anamorph of the mushroom Coprinus cinereus, is reported for a patient receiving treatment for a second relapse of acute lymphoblastic leukemia. The filamentous basidiomycete was identified with restriction fragment length polymorphism patterns of PCR-amplified internally transcribed spacers and small subunit ribosomal DNA with four restriction enzymes. The patient failed to respond to treatment with amphotericin B and itraconazole. The fungus was cultured from the lungs at autopsy: the MIC of amphotericin B for the fungus was low (0.5 mg/liter), and that of itraconazole was high (8 mg/liter).
Verweij
P E
PE
Department of Medical Microbiology, University Hospital Nijmegen, The Netherlands.
van Kasteren
M
M
van de Nes
J
J
de Hoog
G S
GS
de Pauw
B E
BE
Meis
J F
JF
D000328:Adult; D000666:Amphotericin B / Q000494:pharmacology; D001980:Bronchi / Q000382:microbiology / Q000473:pathology; D003302:Coprinus / Q000187:drug effects / Q000235:genetics / Q000302:isolation & purification / Q000472:pathogenicity*; D004275:DNA, Ribosomal / Q000235:genetics; D006801:Humans; D008168:Lung / Q000382:microbiology / Q000473:pathology; D008172:Lung Diseases, Fungal / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy / Q000401:mortality; D008297:Male; D008826:Microbial Sensitivity Tests; D016133:Polymerase Chain Reaction; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000628:therapy; D012335:RNA, Ribosomal / Q000235:genetics; D012008:Recurrence
D004275:DNA, Ribosomal; D012335:RNA, Ribosomal; D000666:Amphotericin B