title: Effect of booster vaccination with a multivalent clostridial bacterin-toxoid on sudden death syndrome mortality rate among feedlot cattle.
abstract: OBJECTIVE
  To determine whether booster vaccination with a multivalent clostridial bacterin-toxoid would affect the sudden death syndrome (SDS) mortality rate among feedlot cattle.
  
  
  METHODS
  Field trial.
  
  
  METHODS
  83, 115 cattle at a Nebraska feedlot.
  
  
  METHODS
  Cattle arriving at the feedlot underwent routine processing according to established protocol. All cattle received a sequentially numbered ear tag and a 2-ml dose of a multivalent bacterin-toxoid designed to protect cattle against Clostridium chauvoei, C speticum, C novyi, C sordellii, and C perfringens types C and D. Approximately 90 days prior to slaughter, growth promotants were implanted in all cattle, and cattle were allocated to a treatment or control group on the basis of the last digits of their ear tag numbers. Cattle in the treatment group received a second 2-ml dose of clostridial bacterintoxoid; control cattle did not.
  
  
  RESULTS
  Significant differences between groups in regard to crude, feeding pen, or SDS mortality rates were not detected. Sudden death syndrome mortality rate across both groups was 0.24%. If the SDS mortality rate in midwestern feedlot cattle was reduced > or = 40% by booster vaccination with a multivalent clostridial bacterin-toxoid, this experiment included enough animals to have a 90% probability of detecting that difference.
  
  
  CONCLUSIONS
  Booster vaccination with a multivalent clostridial bacterin-toxoid does not affect SDS mortality rate among feedlot cattle.
authors.affiliation: Department of Veterinary and Biomedical Sciences, Great Plains Veterinary Educational Center, University of Nebraska-Lincoln, Clay Center 68933, USA.
authors.forename: B
authors.initials: B
authors.lastname: De Groot
authors.forename: C E
authors.initials: CE
authors.lastname: Dewey
authors.forename: D D
authors.initials: DD
authors.lastname: Griffin
authors.forename: L J
authors.initials: LJ
authors.lastname: Perino
authors.forename: R A
authors.initials: RA
authors.lastname: Moxley
authors.forename: G L
authors.initials: GL
authors.lastname: Hahn
mesh_terms: D000818:Animals; D000907:Antibodies, Bacterial / Q000276:immunology; D001428:Bacterial Vaccines / Q000008:administration & dosage* / Q000276:immunology; D002417:Cattle; D002418:Cattle Diseases / Q000453:epidemiology / Q000276:immunology / Q000401:mortality*; D003013:Clostridium / Q000276:immunology* / Q000378:metabolism; D003015:Clostridium Infections / Q000276:immunology / Q000401:mortality / Q000662:veterinary*; D003362:Cost-Benefit Analysis; D003645:Death, Sudden / Q000209:etiology / Q000662:veterinary*; D004305:Dose-Response Relationship, Drug; D007117:Immunization, Secondary / Q000191:economics / Q000662:veterinary*; D009329:Nebraska / Q000453:epidemiology; D013577:Syndrome; D014121:Toxoids / Q000276:immunology / Q000494:pharmacology*; D015164:Vaccines, Inactivated / Q000008:administration & dosage / Q000276:immunology
chemical_list: D000907:Antibodies, Bacterial; D001428:Bacterial Vaccines; D014121:Toxoids; D015164:Vaccines, Inactivated