title: Aging rat vestibular ganglion: II. Quantitative electron microscopic evaluation.
abstract: This laboratory has shown that age-related vestibular ganglion cell loss does not occur in the Wistar rat as it does in humans. However, in that study, intracellular changes were evident. The purpose of the present study was to quantitate some of these changes. The volume densities of mitochondria, rough endoplasmic reticulum (RER), Golgi apparatus, and aging pigment, as well as the diameter of the vestibular ganglion cells, of young (3 to 5 months) and old (24 to 31 months) female Wistar rats were determined by electron microscopy and stereological techniques. The data show a significant decrease in the volume densities of mitochondria (11.4%), Golgi apparatus (8.1%), and RER (8.9%), a significant increase in aging pigment (327%), and no change in mean profile diameter. These results suggest a decreased capacity for oxidative metabolism and protein synthesis that may reflect a decrease in the number of hair cells innervated by each ganglion cell and/or in the number of central connections. In either case, these findings suggest impaired metabolic and functional capabilities.
authors.affiliation: Department of Otolaryngology and Communication Sciences, State University of New York Health Science Center, Syracuse 13210, USA.
authors.forename: M J
authors.initials: MJ
authors.lastname: Lyon
authors.forename: J M
authors.initials: JM
authors.lastname: King
mesh_terms: D000375:Aging; D000818:Animals; D005260:Female; D008854:Microscopy, Electron; D008928:Mitochondria / Q000648:ultrastructure; D051381:Rats; D017208:Rats, Wistar; D013136:Spiral Ganglion / Q000648:ultrastructure*; D014725:Vestibular Nerve / Q000648:ultrastructure*