Comparison of HPLC and CE for the analysis of dichlorprop in a case of intoxication.
A 49-year-old white male was found lying unconscious at home. He had vomited, his mouth was filled with a white foam and a pungent odour filled the room. After emergency treatment blood, urine and stomach contents were screened for drugs after acid and alkaline extraction with subsequent derivatisation and GC-MS analysis. Large quantites of 2,4-dichlorophenoxypropionic acid (dichlorprop, 2,4-DP) were found in all acid extracts. The man died 3 h later in hospital. Body fluids and tissues obtained at autopsy were analysed for 2,4-DP by high-performance liquid chromatography and capillary electrophoresis. The concentrations of 2,4-DP in cardiac blood, stomach contents, bile, liver, spleen, kidney and brain found by both methods were very similar.
West
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A
Institut für Rechtsmedizin, Westfälische Wilhelms-Universität, Münster, Germany. west@uni-muenster.de
Frost
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M
Köhler
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H
D015084:2,4-Dichlorophenoxyacetic Acid / Q000031:analogs & derivatives* / Q000032:analysis / Q000506:poisoning; D002851:Chromatography, High Pressure Liquid; D019075:Electrophoresis, Capillary; D006540:Herbicides / Q000032:analysis* / Q000506:poisoning; D006801:Humans; D008297:Male; D008875:Middle Aged; D011041:Poisoning / Q000473:pathology*; D015203:Reproducibility of Results
D006540:Herbicides; D015084:2,4-Dichlorophenoxyacetic Acid; C010571:dichlorprop