title: Uptake of genetic testing for cancer predisposition.
abstract: Although there has been much debate about the uptake and effects of predictive testing for common cancers, such as breast and colon cancer, little has been published on the more classical tumour predisposing conditions, such as von Hippel-Lindau disease and familial adenomatous polyposis. Since 1990 the genetics departments in Manchester and Cambridge have had a genetic register for cancer predisposing syndromes and presymptomatic testing for these conditions has been offered once this has become possible. To investigate the factors that might influence uptake of genetic testing in familial cancer syndromes we have reviewed our experience. Demand for predictive testing has generally been high, but men had a lower uptake (77%) than a comparable group of women (93%) (p < 0.01).
authors.affiliation: CRC Department of Cancer Genetics, Paterson Institute for Cancer Research, Christie Hospital, Manchester, UK.
authors.forename: D G
authors.initials: DG
authors.lastname: Evans
authors.forename: E R
authors.initials: ER
authors.lastname: Maher
authors.forename: R
authors.initials: R
authors.lastname: Macleod
authors.forename: D R
authors.initials: DR
authors.lastname: Davies
authors.forename: D
authors.initials: D
authors.lastname: Craufurd
mesh_terms: D011125:Adenomatous Polyposis Coli / Q000235:genetics*; D000293:Adolescent; D000328:Adult; D001294:Attitude to Health; D002648:Child; D002675:Child, Preschool; D005260:Female; D005817:Genetic Counseling / Q000706:statistics & numerical data*; D005820:Genetic Testing / Q000592:standards; D006579:Heterozygote; D006801:Humans; D016864:Li-Fraumeni Syndrome / Q000235:genetics*; D008297:Male; D009154:Mutation; D016518:Neurofibromatosis 2 / Q000235:genetics*; D016159:Tumor Suppressor Protein p53 / Q000235:genetics; D006113:United Kingdom; D006623:von Hippel-Lindau Disease / Q000235:genetics*
chemical_list: D016159:Tumor Suppressor Protein p53