title: Transient worsening of Parkinson's disease after cigarette smoking.
abstract: We report a patient with probable Parkinson's disease who experienced a temporary worsening of his symptoms and signs after cigarette smoking. Deterioration of tremor, rigidity, and writing disturbance began soon after the inhalation of cigarette smoke and persisted for 15 minutes. Chewing nicotine gum also induced a brief worsening of the patient's symptoms. Aggravation of parkinsonian symptoms after cigarette smoking appeared to be caused by nicotine alone, although the mechanism for this effect remains unclear.
authors.affiliation: Fifth Department of Internal Medicine, Hyogo College of Medicine.
authors.forename: H
authors.initials: H
authors.lastname: Nishimura
authors.forename: H
authors.initials: H
authors.lastname: Tachibana
authors.forename: B
authors.initials: B
authors.lastname: Okuda
authors.forename: M
authors.initials: M
authors.lastname: Sugita
mesh_terms: D000328:Adult; D018450:Disease Progression; D006801:Humans; D008297:Male; D009127:Muscle Rigidity / Q000209:etiology; D009538:Nicotine / Q000009:adverse effects; D010300:Parkinson Disease / Q000503:physiopathology*; D012907:Smoking / Q000009:adverse effects*; D013997:Time Factors; D014202:Tremor / Q000209:etiology
chemical_list: D009538:Nicotine