The use of herpes simplex virus-based vectors for gene delivery to the nervous system.
The ability of herpes simplex virus (HSV) to establish a lifelong, latent infection within neurons has led to much interest in the development of HSV-based vectors for neuronal gene delivery. This review discusses the progress made towards the construction of safe, replication-disabled HSV vectors that are capable of directing long-term transgene expression in latently infected neurons. Such vectors are now being investigated in a variety of animal model systems, with a view to developing gene therapy approaches to a number of metabolic and degenerative neurological diseases.
Lachmann
R H
RH
Dept. of Pathology, University of Cambridge, UK.
Efstathiou
S
S
D000818:Animals; D004279:DNA, Viral / Q000235:genetics / Q000378:metabolism; D004195:Disease Models, Animal; D005786:Gene Expression Regulation; D018014:Gene Transfer Techniques; D015316:Genetic Therapy / Q000379:methods*; D005822:Genetic Vectors; D006801:Humans; D019636:Neurodegenerative Diseases / Q000235:genetics / Q000628:therapy; D009474:Neurons / Q000378:metabolism* / Q000821:virology; D018139:Simplexvirus / Q000235:genetics* / Q000502:physiology; D019076:Transgenes; D017735:Virus Latency
D004279:DNA, Viral