Methylene blue--a promising treatment modality in sepsis induced by bowel perforation.
In this study, we compared the effects of methylene blue (MB) and an L-arginine analogue on host outcome, blood pressure, lung injury, and nitric oxide (NO) production in rats following fecal peritonitis induced by cecal ligation and puncture (CLP). Sepsis syndrome was induced in 90 rats: 30 were treated with MB, 30 with an NO synthase inhibitor, and 30 with normal saline. We found significantly less alveolar damage, higher blood pressure, better respiratory function, and delayed mortality among animals treated with MB compared to the control group. We conclude that the ability of MB to reduce alveolar damage and therefore to delay mortality in this animal septic shock model may give this harmless substance a role among the treatment modalities of septic shock syndrome induced by fecal peritonitis.
Galili
Y
Y
Department of Surgery B, Tel Aviv Sourasky Medical Center, Israel.
Kluger
Y
Y
Mianski
Z
Z
Iaina
A
A
Wollman
Y
Y
Marmur
S
S
Soffer
D
D
Chernikovsky
T
T
Klausner
J P
JP
Robau
M Y
MY
D000818:Animals; D004791:Enzyme Inhibitors / Q000627:therapeutic use; D007416:Intestinal Perforation / Q000150:complications*; D008168:Lung / Q000187:drug effects / Q000473:pathology; D008297:Male; D008751:Methylene Blue / Q000627:therapeutic use*; D009569:Nitric Oxide / Q000096:biosynthesis; D019335:Nitroarginine / Q000627:therapeutic use; D010538:Peritonitis / Q000188:drug therapy* / Q000209:etiology* / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
D004791:Enzyme Inhibitors; D019335:Nitroarginine; D009569:Nitric Oxide; D008751:Methylene Blue