title: Dramatic effect on oxygenation in patients with severe acute lung insufficiency treated in the prone position.
abstract: OBJECTIVE
  To confirm the positive effect of prone positioning on oxygenation in patients with acute lung insufficiency.
  
  
  METHODS
  Clinical follow-up study.
  
  
  METHODS
  The intensive care unit at a tertiary care academic hospital.
  
  
  METHODS
  Thirteen patients suffering from severe acute lung insufficiency caused by trauma, septicemia, aspiration, and burn injury. Eleven of the patients had severe hypoxia (oxygenation indices [PaO2/FIO2] < or = 80 torr [< or = 10.7 kPa]). Patients > 70 yrs of age were excluded from the study.
  
  
  METHODS
  Treatment in the prone position without changing other ventilatory settings than FIO2 when saturation increased.
  
  
  RESULTS
  Twelve of the 13 patients responded to treatment in the prone position. The patient that did not respond improved her gas exchange when nitric oxide was instituted. She died, however, from a Gram-negative septicemia. No patient needed extracorporeal membrane oxygenation. Apart from the settings of FIO2 when saturation increased, the ventilatory settings were unchanged. In the prone position, the oxygenation index increased (p < .0002) and the alveolar-arterial oxygen gradient, P(A-a)O2, decreased dramatically (p < .0001).
  
  
  CONCLUSIONS
  The prone position significantly improves impaired gas exchange due to severe acute lung insufficiency. It is suggested that this treatment is used before more complex modalities.
authors.affiliation: Department of Anesthesiology and Intensive Care, Karolinska Hospital and Institute, Stockholm, Sweden.
authors.forename: M
authors.initials: M
authors.lastname: Mure
authors.forename: C R
authors.initials: CR
authors.lastname: Martling
authors.forename: S G
authors.initials: SG
authors.lastname: Lindahl
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D003422:Critical Care; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D010101:Oxygen Consumption; D016684:Prone Position; D011659:Pulmonary Gas Exchange; D012131:Respiratory Insufficiency / Q000378:metabolism* / Q000503:physiopathology / Q000628:therapy*; D016683:Supine Position; D016019:Survival Analysis; D013997:Time Factors
chemical_list: D010100:Oxygen