Influence of OprM expression on multiple antibiotic resistance in Pseudomonas aeruginosa.
MexA-MexB-OprM is an efflux system in Pseudomonas aeruginosa. OprM overproduced from the cloned gene was able to complement OprM-deficient mutants but did not alter the resistance of a wild-type P. aeruginosa strain to the different antimicrobial agents tested. This suggests that OprM cannot function by itself to efflux antibiotics, including beta-lactams targeted to the periplasm.
Wong
K K
KK
Department of Microbiology and Immunology, University of British Columbia, Vancouver, Canada.
Poole
K
K
Gotoh
N
N
Hancock
R E
RE
D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics / Q000494:pharmacology; D001425:Bacterial Outer Membrane Proteins / Q000096:biosynthesis / Q000235:genetics / Q000378:metabolism*; D018432:Drug Resistance, Multiple / Q000502:physiology*; D015870:Gene Expression; D007769:Lactams; D008826:Microbial Sensitivity Tests; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D001425:Bacterial Outer Membrane Proteins; D007769:Lactams