Replicative senescence of T cells: does the Hayflick Limit lead to immune exhaustion?
Extensive in vitro research on fibroblasts has defined numerous genetic and phenotypic changes associated with replicative senescence. Identification of T-cell replicative senescence as a feature of human immunodeficiency virus (HIV) disease and ageing suggests this phenomenon merits more careful consideration by immunologists, especially with regard to chronic infection, memory and adoptive immunotherapy.
Effros
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RB
Dept of Pathology and Laboratory Medicine, UCLA School of Medicine 90095-1732, USA. reffros@pathology.medsch.ucla.edu
Pawelec
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G
D000486:Allergy and Immunology / Q000639:trends; D000818:Animals; D002455:Cell Division / Q000276:immunology; D016922:Cellular Senescence / Q000276:immunology*; D006801:Humans; D066298:In Vitro Techniques; D008954:Models, Biological; D013601:T-Lymphocytes / Q000166:cytology* / Q000276:immunology*; D016615:Telomere / Q000648:ultrastructure