Synthesis and antiinflammatory activity of novel pyrimidine derivatives.
Hydrazinolysis of ethyl [(4-methyl-6-phenylpyrimidin-2-yl)oxy]acetate (1) gives the unexpected bis(4-methyl-6-phenylpyrimidin-2-yl)hydrazine (2). The desired [(4 methyl-6-phenylpyrimidin-2-yl)oxy]acetohydrazide (3) was prepared from the ester (1) with hydrazine in absolute ethanol. Starting from 3, several new hydrazones, 1,3,4 oxadiazoles, 1,3,4-thiadiazoles, 1,2,4-triazoles and 1,3-thiazoles have been synthesized. Structure of the new compounds was confirmed by elemental analysis, spectral data and alternative synthesis in certain cases. Some representative examples were evaluated for their antiinflammatory activities.
al-Ashmawy
M I
MI
Department of Organic Pharmaceutical Chemistry, Faculty of Pharmacy, Zagazig University, Egypt.
el-Feky
S A
SA
el-Samii
Z K
ZK
Osman
N A
NA
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000494:pharmacology; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D005260:Female; D008297:Male; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats
D000894:Anti-Inflammatory Agents, Non-Steroidal; D011743:Pyrimidines