title: [Effectiveness of ciprofloxacin in the treatment of hospital infections of the lower respiratory tract].
abstract: The efficacy of ciprofloxacin was studied in the treatment of 22 patients with hospital infection of the lower respiratory tract: 10 patients with nosocomial pneumonia, 8 with exacerbation of chronic obstructive bronchitis, 3 with exacerbation of mucoviscidosis and 1 with bronchiectasis. The drug was administered intravenously in a dose of 200 to 400 mg or orally in a dose of 500 to 750 mg twice a day for 6 to 21 days. The clinical and bacteriological efficacies of ciprofloxacin amounted to 90.9 and 86.4 per cent respectively. The treatment failed in 2 patients: 1 with pneumonia due to Streptococcus pneumoniae and 1 with mucoviscidosis and persistence of Pseudomonas aeruginosa. Ciprofloxacin was well tolerated. The side effects were observed in 2 patients and required no discontinuation of the drug use.
authors.forename: A G
authors.initials: AG
authors.lastname: Chuchalin
authors.forename: Iu K
authors.initials: IuK
authors.lastname: Novikov
authors.forename: S N
authors.initials: SN
authors.lastname: Avdeev
authors.forename: A S
authors.initials: AS
authors.lastname: Belevskiĭ
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000368:Aged; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D001987:Bronchiectasis / Q000188:drug therapy; D001991:Bronchitis / Q000188:drug therapy; D002908:Chronic Disease; D002939:Ciprofloxacin / Q000627:therapeutic use*; D003428:Cross Infection / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018410:Pneumonia, Bacterial / Q000188:drug therapy; D012141:Respiratory Tract Infections / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D000890:Anti-Infective Agents; D002939:Ciprofloxacin