title: Hormone-cytokine response. Pneumoperitoneum vs abdominal wall-lifting in laparoscopic cholecystectomy.
abstract: BACKGROUND
  Changes in blood hormone and cytokine were investigated in patients who underwent laparoscopic cholecystectomy via insufflation (CO2 group) vs those who had abdominal wall-lifting (Air group).
  
  
  METHODS
  Seventeen female patients with cholecystolithiasis were randomly divided into two groups. Peripheral blood samples were obtained during perioperative period, and plasma hormone levels (ACTH, cortisol) and serum cytokine levels (TNFalpha, IL-1beta, IL-6, IL-10) were measured.
  
  
  RESULTS
  The number of circulating lymphocytes significantly decreased at 1 h after surgery in both groups, but the decrease in the CO2 group was significantly smaller than that in the Air group. There was no significant difference in hormone elevation between groups. Serum concentrations of IL-6 and IL-10 in the Air group were significantly higher than in the CO2 group.
  
  
  CONCLUSIONS
  CO2 insufflation may reduce cytokine production in laparoscopic cholecystectomy.
authors.affiliation: Department of Surgery, Omiya Medical Center, Jichi Medical School, 3311-1 Kawati-gun, Tochigi 329-04, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Yoshida
authors.forename: E
authors.initials: E
authors.lastname: Kobayashi
authors.forename: Y
authors.initials: Y
authors.lastname: Suminaga
authors.forename: H
authors.initials: H
authors.lastname: Yamauchi
authors.forename: T
authors.initials: T
authors.lastname: Kai
authors.forename: N
authors.initials: N
authors.lastname: Toyama
authors.forename: H
authors.initials: H
authors.lastname: Kiyozaki
authors.forename: A
authors.initials: A
authors.lastname: Fujimura
authors.forename: M
authors.initials: M
authors.lastname: Miyata
mesh_terms: D000009:Abdominal Muscles / Q000601:surgery; D000324:Adrenocorticotropic Hormone / Q000097:blood; D000328:Adult; D000368:Aged; D002245:Carbon Dioxide / Q000627:therapeutic use; D017081:Cholecystectomy, Laparoscopic / Q000379:methods*; D002769:Cholelithiasis / Q000097:blood / Q000601:surgery*; D016207:Cytokines / Q000097:blood* / Q000378:metabolism; D005260:Female; D005768:Gastrointestinal Hormones / Q000097:blood* / Q000378:metabolism; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007375:Interleukin-1 / Q000097:blood; D016753:Interleukin-10 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D008875:Middle Aged; D011028:Pneumoperitoneum, Artificial; D011379:Prognosis; D012680:Sensitivity and Specificity; D013514:Surgical Procedures, Operative / Q000379:methods*; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis
chemical_list: D016207:Cytokines; D005768:Gastrointestinal Hormones; D007375:Interleukin-1; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10; D002245:Carbon Dioxide; D000324:Adrenocorticotropic Hormone; D006854:Hydrocortisone