Non-oxidative modification of low density lipoprotein by ruptured myocytes.
In this study, the interaction of ruptured cardiac myocytes with low density lipoprotein (LDL) has been investigated and the consequent extent of uptake by macrophages. The results show that lysate released from ruptured myocytes is capable of inducing LDL oxidation and that the resulting modified form is recognised and degraded by macrophages. Peroxyl radical scavengers inhibit the LDL oxidation but not the macrophage uptake suggesting that LDL can be modified by mechanisms that are independent of oxidative processes by intracellular constituents of cardiac myocytes.
Bourne
L C
LC
International Antioxidant Research Centre, UMDS-Guy's Hospital, London, UK.
Lamb
D J
DJ
Collis
C S
CS
O'Brien
M
M
Leake
D S
DS
Rice-Evans
C
C
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D002084:Butylated Hydroxytoluene / Q000494:pharmacology; D002457:Cell Extracts / Q000494:pharmacology; D002478:Cells, Cultured; D005260:Female; D016166:Free Radical Scavengers / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D008077:Lipoproteins, LDL / Q000187:drug effects / Q000378:metabolism*; D017737:Macrophages, Peritoneal / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051379:Mice; D009206:Myocardium / Q000166:cytology* / Q000378:metabolism; D009211:Myoglobin / Q000378:metabolism / Q000494:pharmacology; D010084:Oxidation-Reduction; D011069:Poly I / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar
D000975:Antioxidants; D002457:Cell Extracts; D016166:Free Radical Scavengers; D008077:Lipoproteins, LDL; D009211:Myoglobin; D002084:Butylated Hydroxytoluene; D011069:Poly I