Red cell aplasia caused by parvovirus B19 in AIDS: use of i.v. immunoglobulin.
We describe the case of a 34-year-old man with AIDS who developed severe anemia due to chronic pure red cell aplasia (PRCA) caused by parvovirus B19. Following initial treatment with an infusion of intravenous immunoglobulin (IVIg), 1 g/kg, PRCA resolved, but there was a recurrence of severe anemia in 3 months. Retreatment with 2 g/kg IVIg over 2 days resulted in normalization of hemoglobin and a significantly longer remission duration. Two doses of 0.4 g/kg IVIg q 4 wk failed to prevent a relapse of PRCA in our patient. The dose and schedule of IVIg in the treatment of PRCA caused by parvovirus B19 in AIDS requires further definition.
Koduri
P R
PR
Department of Medicine, Cook County Hospital, Chicago, IL 60612, USA.
Kumapley
R
R
Khokha
N D
ND
Patel
A R
AR
D017088:AIDS-Related Opportunistic Infections / Q000628:therapy / Q000821:virology; D000328:Adult; D017809:Fatal Outcome; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D008297:Male; D016732:Parvovirus B19, Human; D012010:Red-Cell Aplasia, Pure / Q000209:etiology* / Q000628:therapy / Q000821:virology; D012514:Sarcoma, Kaposi / Q000150:complications
D016756:Immunoglobulins, Intravenous