[Mutagenic and antimutagenic activities of human whole blood, plasma and albumin].
The seeds of Crepis capillaris were used to examine the mutagenic und antimutagenic properties of human whole blood, plasma, serum albumin and gamma-globulin by recording chromosomal and chromatid aberrations. The antimutagenic activity was determined by preliminary, simultaneous, and subsequent biosubstrate treatments of the seeds. The whole and twice-diluted blood, as well as plasma, induced aberrations exceeding the level of self-arbitrary mutagenesis by 3.7-5.3 and 2.6-3.1 times, respectively. When the blood was diluted to its 20% concentration, the antimutagenic efficiency of biological fluids was recorded. Human serum albumin and gamma-globulin were found to have an antimutagenic effect. In the dilutions having no antimutagenic effect, blood, plasma, and albumin showed their ability to be effectively decrease the level of induced aberrations.
Semenov
V V
VV
State Medical University, Kazan'.
Koshpaeva
E S
ES
D016587:Antimutagenic Agents / Q000494:pharmacology*; D001769:Blood; D002869:Chromosome Aberrations / Q000235:genetics; D006801:Humans; D019684:Magnoliopsida / Q000187:drug effects / Q000235:genetics; D016296:Mutagenesis / Q000187:drug effects* / Q000235:genetics; D009153:Mutagens / Q000494:pharmacology*; D010949:Plasma; D012709:Serum Albumin
D016587:Antimutagenic Agents; D009153:Mutagens; D012709:Serum Albumin