Lack of association between schizophrenia and a polymorphism close to the cytosolic phospholipase A2 gene.
Biochemical studies have shown that a proportion of schizophrenics have an abnormal fatty acid composition in their red blood-cell membrane phospholipids and it has been suggested that this might be due to altered levels of the enzyme phospholipase A2 (PLA2). A recent report indicated that there was an association between schizophrenia and alleles of a poly-A repeat polymorphism close to the 5' end of the PLA2 gene. We report the analysis of this polymorphism in a series of 58 schizophrenic patients and 56 controls and find no evidence for allelic association.
Price
S A
SA
Department of Molecular & Cell Biology, University of Aberdeen Medical School, UK.
Fox
H
H
St Clair
D
D
Shaw
D J
DJ
D000483:Alleles; D003600:Cytosol / Q000201:enzymology; D004247:DNA / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D010741:Phospholipases A / Q000235:genetics*; D054467:Phospholipases A2; D011061:Poly A; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012016:Reference Values; D012091:Repetitive Sequences, Nucleic Acid; D012559:Schizophrenia / Q000201:enzymology / Q000235:genetics*
D011061:Poly A; D004247:DNA; D010741:Phospholipases A; D054467:Phospholipases A2