[The presynaptic mechanism of interaction of cholinesterase reactivator and muscarinic antagonists in the animal's defence in organophosphate intoxication].
The presynaptic and antidote activity of various combinations of cholinesterase reactivators and that of muscarinic antagonist were compare it was show that the mechanism of the antidote effect of some cholinesterase reactivators in poisoning with organophosphorous compounds, in addition to restoring the activity of the enzyme, includes the effect of counteraction to the effect of muscarinic antagonists in increased acetylcholine secretion into the synaptic cleft. The expression of this effect depends on the presynaptic activity of the reactivator and on the selectivity of muscarinic antagonist. It is suggested that the type relation of the presynaptic muscarin receptors in the cerebral hemispheres and the brain stem is different and that the probability of the functional value of the ligand presynaptic interaction for the protection from organophosphorous compounds is higher in the brain higher in the brain stem than in the cerebral hemispheres of rats.
Kosmachev
A B
AB
Fillipov
V N
VN
Podosinovikova
N P
NP
Dolgo-Saburov
V B
VB
D000109:Acetylcholine / Q000378:metabolism; D000818:Animals; D001667:Binding, Competitive; D001933:Brain Stem / Q000187:drug effects / Q000378:metabolism; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism; D002801:Cholinesterase Reactivators / Q000378:metabolism / Q000493:pharmacokinetics / Q000494:pharmacology*; D004347:Drug Interactions; D004357:Drug Synergism; D007306:Insecticides / Q000506:poisoning* / Q000633:toxicity; D007928:Lethal Dose 50; D008297:Male; D018727:Muscarinic Antagonists / Q000378:metabolism / Q000493:pharmacokinetics / Q000494:pharmacology*; D009946:Organothiophosphorus Compounds; D017729:Presynaptic Terminals / Q000187:drug effects*; D051381:Rats; D011976:Receptors, Muscarinic / Q000187:drug effects / Q000378:metabolism
D002801:Cholinesterase Reactivators; D007306:Insecticides; D018727:Muscarinic Antagonists; D009946:Organothiophosphorus Compounds; D011976:Receptors, Muscarinic; D000109:Acetylcholine