title: [Hansen's disease and nephropathy as its sequence].
abstract: Nephropathy as the sequences of Hansen's disease before and after the introduction of chemotherapy was compared referring to the report by Hayashi in 1943 and the summary of the autopsy reports from 1978 to 1981 at National Hansen's disease hospital Zenseien. Unlike the high rates of tuberculosis as the cause of death before the introduction of chemotherapy (41.3%) those thereafter decreased to be negligible. On the other hand the comparison of the rates of nephropathy with the same way as that of tuberculosis was impossible since the description about nephropathy by Hayashi was not sufficient to characterize each nephropathy since he included arteriolitis, glomerulonephritis and interstitial nephritis together in the term of nephritis. Death rate due to nephritis among Hansen's disease patients according to Hayashi at that time was 21.2% which was twice as many comparing to that in the other cases. According to the report about the cases of Zenseien those reported to have glomerulonephritis was 37.3% though those were not necessarily listed as the cause of death. Also the nephropathy including fibrinoid angitis with occasional microaneurysmal dilatation of afferent arteries, glomerulitis, sclerosis and stricture of efferent arteries likewise ischemic acute tubular necrosis possibly as the result of these angiopathy seemed to be present. These vascular changes partially resemble to that of microscopic periarteritis nodosa but seems to be common in the smaller arteries. In conclusion, unlike the case of tuberculosis the rate of nephritis including glomerulitis, arteriolitis and interstitial nephritis as Hayashi used as his criteria does not seem to have decreased. Therefore, the critical analysis of the nephropathy especially of that relating to the arteriolitis should be done to obtain the knowledge to suppress its occurrence.
authors.affiliation: Department of Pathology Kyorin University School of Medicine, Tokyo, Japan.
authors.forename: E
authors.initials: E
authors.lastname: Matsuo
authors.forename: Y
authors.initials: Y
authors.lastname: Furuno
authors.forename: A
authors.initials: A
authors.lastname: Komatsu
authors.forename: S
authors.initials: S
authors.lastname: Maekawa
authors.forename: K
authors.initials: K
authors.lastname: Murata
authors.forename: H
authors.initials: H
authors.lastname: Sidik
authors.forename: T
authors.initials: T
authors.lastname: Kikuchi
authors.forename: N
authors.initials: N
authors.lastname: Sasaki
mesh_terms: D001167:Arteritis / Q000209:etiology / Q000473:pathology; D006801:Humans; D007668:Kidney / Q000473:pathology*; D007917:Leprostatic Agents / Q000009:adverse effects; D007918:Leprosy / Q000150:complications*; D009393:Nephritis / Q000209:etiology / Q000473:pathology*; D012077:Renal Artery / Q000473:pathology
chemical_list: D007917:Leprostatic Agents