title: Comparative antianaerobic activities of the ketolides HMR 3647 (RU 66647) and HMR 3004 (RU 64004).
abstract: HMR 3647 (RU 66647) and HMR 3004 (RU 64004), two ketolides, had MICs at which 50% of the strains are inhibited (MIC50s) of 0.06 to 0.125 microg/ml and MIC90s of 16.0 microg/ml against 352 anaerobes. MIC50s and MIC90s of erythromycin, azithromycin, clarithromycin, and roxithromycin were 0.5 to 2.0 microg/ml and 32.0 to >64.0 microg/ml, respectively. HMR 3647 and HMR 3004 were more active against non-Bacteroides fragilis-group anaerobes (other than Fusobacterium mortiferum, Fusobacterium varium, and Clostridium difficile).
authors.affiliation: Department of Pathology (Clinical Microbiology), Hershey Medical Center, Pennsylvania 17033, USA.
authors.forename: L M
authors.initials: LM
authors.lastname: Ednie
authors.forename: M R
authors.initials: MR
authors.lastname: Jacobs
authors.forename: P C
authors.initials: PC
authors.lastname: Appelbaum
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D017963:Azithromycin / Q000494:pharmacology; D001421:Bacteria, Anaerobic / Q000187:drug effects*; D002245:Carbon Dioxide / Q000378:metabolism; D017291:Clarithromycin / Q000494:pharmacology; D004917:Erythromycin / Q000494:pharmacology; D006863:Hydrogen-Ion Concentration; D048628:Ketolides; D018942:Macrolides; D008826:Microbial Sensitivity Tests; D015575:Roxithromycin / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D048628:Ketolides; D018942:Macrolides; C105420:RU 64004; D002245:Carbon Dioxide; D015575:Roxithromycin; D004917:Erythromycin; D017963:Azithromycin; D017291:Clarithromycin; C106791:telithromycin