title: Adrenal glands imaging with indium-111-DTPA-D-Phe1-octreotide following ACTH therapy.
abstract: Somatostatin receptors have been identified in a variety of neuroendocrine tumors and activated leukocytes. A high density of somatostatin receptors is also present in most intestinal intramural veins of patients with inflammatory bowel disease. We present a case of a 25-yr-old female with severe Crohn's disease unresponsive to medical therapy, including adrenocorticotropic hormone (ACTH) administration. The patient underwent (111)In-DTPA octreotide scintigraphy to evaluate the potential role of somatostatin receptor imaging in inflammatory bowel disease. Despite the lack of significant somatostatin receptors in the affected bowel, an unexpected prominent activity of (111)In-DTPA octreotide was noted in the adrenal glands on the SPECT images, presumably resulting from excessive stimulation by ACTH. The expression of somatostatin receptors in the stimulated adrenals may be used to image other adrenal pathologies and could potentially indicate response to therapy.
authors.affiliation: Department of Radiology, Mount Sinai School of Medicine, New York, New York 10029, USA.
authors.forename: M
authors.initials: M
authors.lastname: Lorberboym
authors.forename: P
authors.initials: P
authors.lastname: Rubin
authors.forename: R
authors.initials: R
authors.lastname: Warner
authors.forename: J
authors.initials: J
authors.lastname: Machac
mesh_terms: D000311:Adrenal Glands / Q000000981:diagnostic imaging* / Q000378:metabolism; D000324:Adrenocorticotropic Hormone / Q000627:therapeutic use*; D000328:Adult; D003424:Crohn Disease / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000378:metabolism; D005260:Female; D006801:Humans; D015282:Octreotide / Q000031:analogs & derivatives*; D004369:Pentetic Acid / Q000031:analogs & derivatives*; D019275:Radiopharmaceuticals; D017481:Receptors, Somatostatin / Q000032:analysis; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D019275:Radiopharmaceuticals; D017481:Receptors, Somatostatin; C071632:SDZ 215-811; D004369:Pentetic Acid; D000324:Adrenocorticotropic Hormone; D015282:Octreotide