[Strategy of exploration of states of growth hormone hypersecretion].
GH secretion is épisodic in humans. Isolated plasma concentrations thus cannot be used to diagnose excess secretion. Assays on GH secretion require repeat determinations of plasma levels over extended 24 h periods. In so-called conjunctive GH hypersecretion conditions (denutrition, critical states), excessive GH secretion is associated with resistance to this hormone, as indicated by a decrease in plasma IGF-1 concentrations. In contrast, IGF-1 concentrations are high and correlated with GH levels during permanent GH hypersecretion that occurs in acromegaly. Testing for this disorder will vary according to the clinician's objectives.
Sassolas
G
G
Centre de Médecine Nucléaire, Lyon, France.
Cohen
R
R
Tsati
J J
JJ
D000172:Acromegaly / Q000097:blood / Q000503:physiopathology; D000818:Animals; D004701:Endocrine Gland Neoplasms / Q000378:metabolism; D013007:Growth Hormone-Releasing Hormone / Q000378:metabolism; D019382:Human Growth Hormone / Q000378:metabolism*; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D012636:Secretory Rate
D019382:Human Growth Hormone; D007334:Insulin-Like Growth Factor I; D013007:Growth Hormone-Releasing Hormone