Acute erosions of the gastric mucosa in burned rats: effect of sucralfate.
The effect of intragastric sucralfate on development of gastric erosions in burns was studied in 20 rats anaesthetised with midazolam/fentanyl/fluanisone. Gastric blood flow was measured by radioactive microspheres immediately before, and 20, 40, and 120 minutes after the rats had been burned. Significantly fewer erosions were found in the 10 rats treated with sucralfate (less than 2% of the gastric mucosal surface was affected) compared with the controls (16% of the mucosa affected). There was no difference in the rate of gastric blood flow in any part of the stomach between the rats treated with sucralfate and the controls. We conclude that sucralfate is effective in preventing gastric erosions in burned rats, but that other mechanisms of action than increase gastric blood flow are responsible for its protective effect.
Samdal
F
F
Department of Surgery, University of Bergen, Norway.
Grong
K
K
Skolleborg
K C
KC
Grønbech
J E
JE
D000818:Animals; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D002056:Burns / Q000150:complications*; D005753:Gastric Mucosa / Q000098:blood supply* / Q000187:drug effects; D008297:Male; D051381:Rats; D012039:Regional Blood Flow / Q000187:drug effects; D013047:Specific Pathogen-Free Organisms; D013276:Stomach Ulcer / Q000209:etiology / Q000517:prevention & control*; D013312:Stress, Physiological / Q000150:complications*; D013392:Sucralfate / Q000627:therapeutic use*
D000897:Anti-Ulcer Agents; D013392:Sucralfate