[Acute suicidal poisoning with Dapsone].
Course of disease and treatment of 27-years old female patient suffering from celiac disease, who took Dapsone on suicidal purpose in a dose 23 times over maximal daily dose. Methemoglobinemia and hemolysis with anemia typical for this poisoning have been observed. In the first period after intoxication hypokalemia of unknown reason and shedding of hair 7 weeks after intoxication have been noticed. It is remarkable that methemoglobinemia maintained until 8 day after intoxication, in spite of intensive treatment with reducers and blood transfusions. That indicates tissular accumulation of Dapsone. Patient treated with Dapsone shouldn't possess the quantity of this drug that-taken as a single dose-can put him at risk.
Lata
S
S
II Oddziału Chorób Wewnetrznych, Tarnowie.
Wiernikowski
A
A
Janiszewski
J
J
D000328:Adult; D001663:Bilirubin / Q000097:blood; D001772:Blood Cell Count; D002446:Celiac Disease / Q000188:drug therapy; D003622:Dapsone / Q000506:poisoning*; D062787:Drug Overdose; D005260:Female; D006801:Humans; D007501:Iron / Q000097:blood; D008706:Methemoglobin / Q000032:analysis; D013406:Suicide, Attempted
D003622:Dapsone; D008706:Methemoglobin; D007501:Iron; D001663:Bilirubin