[Structural organization of red blood cell membranes in pregnant women with gestosis].
Activated lipid peroxidation (LPO) was found to occur with decreased antioxidative activity (AOA) in gestosis, by deteriorating the structural and functional properties of cell membranes. This enhanced the permeability of the phospholipid bilayer and altered the function of membranous proteins and the synthesis of biologically active agents, by involving the systems responsible for microcirculatory homeostasis. Enhanced membrane hydrophilicity and increased LPO and AOA are typical of the second and third trimesters of normal pregnancy. Pregnant with gestosis generally show higher microviscosity and hydrophilicity of membranes and enhanced blood LPO.
Mikaelian
N P
NP
Russian State Medical University, Moscow.
Kniazev
I A
IA
Maksina
A G
AG
Mikaelian
A V
AV
D002463:Cell Membrane Permeability; D004910:Erythrocyte Membrane / Q000378:metabolism*; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation; D008565:Membrane Proteins / Q000378:metabolism; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy; D011248:Pregnancy Complications; D011262:Pregnancy Trimester, Second; D011263:Pregnancy Trimester, Third
D008565:Membrane Proteins