Pneumonic tularemia in a patient with chronic granulomatous disease.
We report the case of a 14-year-old boy with granulomatous pneumonia caused by Francisella tularensis. In addition, an autosomal recessive form of chronic granulomatous disease was diagnosed. Both F. tularensis and chronic granulomatous disease are associated with pulmonary granulomas. To our knowledge, this is the first report of F. tularensis infection in a patient with chronic granulomatous disease. The relationship between these two processes is discussed.
Maranan
M C
MC
Department of Pediatrics, University of Chicago, Illinois 60611, USA.
Schiff
D
D
Johnson
D C
DC
Abrahams
C
C
Wylam
M
M
Gerber
S I
SI
D000293:Adolescent; D000900:Anti-Bacterial Agents; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D005604:Francisella tularensis / Q000276:immunology; D005808:Genes, Recessive; D006105:Granulomatous Disease, Chronic / Q000150:complications* / Q000235:genetics / Q000276:immunology; D006801:Humans; D008297:Male; D019255:NADPH Oxidases; D009504:Neutrophils / Q000276:immunology / Q000502:physiology; D010750:Phosphoproteins / Q000172:deficiency / Q000235:genetics; D018410:Pneumonia, Bacterial / Q000150:complications* / Q000188:drug therapy / Q000276:immunology; D014406:Tularemia / Q000150:complications* / Q000188:drug therapy / Q000276:immunology
D000900:Anti-Bacterial Agents; D010750:Phosphoproteins; D019255:NADPH Oxidases; C060505:neutrophil cytosolic factor 1