[Change in biochemical and hemostatic indicators in guinea pigs upon administering Ebola virus preparations].
The biochemical and hemostatic parameters were compared in guinea pigs after inoculation of Ebola virus strains lethal and nonlethal for them and of inactivated antigen of this virus. The time course of the main hemostatic and biochemical parameters in animals challenged with the lethal strain of Ebola virus differed much from that in other groups. This permits us to hypothesize that modification of the virus in the course of adaptation to the host results in the appearance of properties boosting the enzymatic processes and, hence, in depletion and failure of antioxidant and hemostatic defence, which aggravates the pathological process.
Chepurnov
A A
AA
Dadaeva
A A
AA
Zhukov
V A
VA
Sizikov
L P
LP
Merzlikin
N V
NV
D000410:Alanine Transaminase / Q000378:metabolism; D000818:Animals; D000936:Antigen-Antibody Complex / Q000097:blood; D001219:Aspartate Aminotransferases / Q000378:metabolism; D002522:Chlorocebus aethiops; D029043:Ebolavirus / Q000276:immunology*; D006487:Hemostasis; D007928:Lethal Dose 50; D015227:Lipid Peroxidation; D008315:Malondialdehyde / Q000378:metabolism; D010976:Platelet Count; D015164:Vaccines, Inactivated / Q000008:administration & dosage*; D014709:Vero Cells; D014765:Viral Vaccines / Q000008:administration & dosage*
D000936:Antigen-Antibody Complex; D015164:Vaccines, Inactivated; D014765:Viral Vaccines; D008315:Malondialdehyde; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase