[TNF].
TNF exerts its biological activities through two distinct receptors of TNF-R55 and TNF-R75. Recent studies have identified TNF receptor-associated molecules, and intracellular signal transduction for apoptosis induced by TNF has been elucidated. Various TNF mutants with higher affinity to TNF-R55 and lower affinity to TNF-R75 are being clarified biogenetically. These mutants show lower adverse effect and higher antitumor activity. Furthermore, TNF gene transduction into lymphocytes and tumor cells shows a decrease in tumorigenicity and enhancement of host immunogenicity. This approach appears to be promising for cancer treatment.
Yamauchi
N
N
Fourth Dept. of Internal Medicine, Sapporo Medical University, School of Medicine.
Niitsu
Y
Y
D000818:Animals; D015703:Antigens, CD / Q000737:chemistry / Q000235:genetics; D000970:Antineoplastic Agents; D017209:Apoptosis; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D010190:Pancreatic Neoplasms / Q000473:pathology / Q000628:therapy; D018124:Receptors, Tumor Necrosis Factor / Q000737:chemistry / Q000145:classification / Q000235:genetics; D047888:Receptors, Tumor Necrosis Factor, Type I; D047889:Receptors, Tumor Necrosis Factor, Type II; D015398:Signal Transduction; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics / Q000502:physiology
D015703:Antigens, CD; D000970:Antineoplastic Agents; D018124:Receptors, Tumor Necrosis Factor; D047888:Receptors, Tumor Necrosis Factor, Type I; D047889:Receptors, Tumor Necrosis Factor, Type II; D014409:Tumor Necrosis Factor-alpha