title: Transjugular intrahepatic portosystemic shunt with silicone-covered Wallstents: results in a swine model.
abstract: OBJECTIVE
  To evaluate the use of impermeable silicone-covered Wallstents for transjugular intrahepatic portosystemic shunt creation.
  
  
  METHODS
  A transjugular intrahepatic portosystemic shunt was created in 14 young swine (weight, 20-32 kg) by using impermeable silicone-covered Wallstents. In eight animals, the silicone covering extended from the portal vein to the inferior vena cava. In two swine, the silicone covering ended short of the inferior vena cava, in two it ended short of the portal vein wall, and in two it ended short at each end. Follow-up transhepatic portal venography was performed weekly for 6 weeks or until the shunt was occluded. Animals were then sacrificed for gross and histologic evaluation.
  
  
  RESULTS
  Only two of 14 shunts were patent after 3 weeks; both were stenosed with luminal narrowing of more than 50% in the middle of the shunt. By 6 weeks, all shunts were occluded. At histologic evaluation, a marked foreign-body reaction with superimposed thrombosis was demonstrated.
  
  
  CONCLUSIONS
  In comparison with uncovered Wallstents, impermeable silicone-covered Wallstents are associated with decreased patency at transjugular intrahepatic portosystemic shunt creation. This is likely due to increased thrombogenicity and a foreign-body reaction.
authors.affiliation: Dotter Interventional Institute, Oregon Health Sciences University, Portland, USA.
authors.forename: H
authors.initials: H
authors.lastname: Tanihata
authors.forename: R R
authors.initials: RR
authors.lastname: Saxon
authors.forename: Y
authors.initials: Y
authors.lastname: Kubota
authors.forename: D
authors.initials: D
authors.lastname: Pavcnik
authors.forename: B T
authors.initials: BT
authors.lastname: Uchida
authors.forename: J
authors.initials: J
authors.lastname: Rosch
authors.forename: F S
authors.initials: FS
authors.lastname: Keller
authors.forename: R
authors.initials: R
authors.lastname: Yamada
authors.forename: M
authors.initials: M
authors.lastname: Sato
mesh_terms: D000818:Animals; D011169:Portal Vein / Q000000981:diagnostic imaging; D019168:Portasystemic Shunt, Transjugular Intrahepatic / Q000009:adverse effects; D011859:Radiography; D012828:Silicones; D015607:Stents / Q000009:adverse effects; D013499:Surface Properties; D013552:Swine; D013927:Thrombosis / Q000209:etiology / Q000473:pathology
chemical_list: D012828:Silicones