title: Isolation and characterization of novel cytotoxic saponins from Archidendron ellipticum.
abstract: A series of new ester saponins, elliptosides A-J, has been isolated from the tropical plant Archidendron ellipticum (Leguminosae). These saponins were particularly cytotoxic to certain renal and melanoma cancer cell lines in the NCI's 60-cell line human tumor screen. The structures of elliptosides A, E, and F were elucidated by spectroscopic and chemical means. Elliptoside A showed in vivo antitumor activity against the LOX melanoma cell line.
authors.affiliation: Laboratory of Drug Discovery Research & Development, National Cancer Institute, Frederick, MD 21702-1201, USA.
authors.forename: J A
authors.initials: JA
authors.lastname: Beutler
authors.forename: Y
authors.initials: Y
authors.lastname: Kashman
authors.forename: L K
authors.initials: LK
authors.lastname: Pannell
authors.forename: J H
authors.initials: JH
authors.lastname: Cardellina
authors.forename: M R
authors.initials: MR
authors.lastname: Alexander
authors.forename: M S
authors.initials: MS
authors.lastname: Balaschak
authors.forename: T R
authors.initials: TR
authors.lastname: Prather
authors.forename: R H
authors.initials: RH
authors.lastname: Shoemaker
authors.forename: M R
authors.initials: MR
authors.lastname: Boyd
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D007887:Fabaceae / Q000737:chemistry*; D006801:Humans; D008958:Models, Molecular; D010946:Plants, Medicinal; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D016339:Spectrometry, Mass, Fast Atom Bombardment; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D012503:Saponins