Expression of several members of the TNF-ligand and receptor family on tonsillar lymphoid B cells.
Although the expression patterns of the members of the tumour necrosis factor receptor and ligand families have extensively been studied by flow-cytometry on stimulated peripheral blood mononuclear cells (PBMNC), little or no flow-cytometric or immunohistological data exist about their expression in lymphoid tissue. According to the data obtained from stimulated PBMNC, several members of these molecule families (e.g. CD40 ligand [CD40L], CD30, CD27, hOX40) have been considered to be either T-cell restricted or strongly T-cell associated. The present study on samples from palatine tonsils revealed that most of these molecules are also expressed by tonsillar B cells. The additional analysis of the co-expression of these molecules also disclosed the existence of CD40+/CD40L+ and CD27+/CD70+ (CD27L+) lymphoid cells in tonsillar tissue.
Dürkop
H
H
Institute of Pathology, Universitätsklinikum Benjamin Franklin, Berlin, Germany.
Anagnostopoulos
I
I
Bulfone-Paus
S
S
Stein
H
H
D015703:Antigens, CD / Q000378:metabolism; D001402:B-Lymphocytes / Q000378:metabolism*; D005434:Flow Cytometry; D006801:Humans; D007150:Immunohistochemistry; D008024:Ligands; D014066:Palatine Tonsil / Q000276:immunology; D018124:Receptors, Tumor Necrosis Factor / Q000378:metabolism*; D013601:T-Lymphocytes / Q000378:metabolism
D015703:Antigens, CD; D008024:Ligands; D018124:Receptors, Tumor Necrosis Factor