title: HLA-DQA1 and polymarker allele frequencies in two New York City Jewish populations.
abstract: Allele and genotype frequencies were determined for the HLA-DQA1 and Amplitype Polymarker loci (low density lipoprotein receptor (LDLR), glycophorin A (GYPA), hemoglobin G gammaglobin (HBGG), D7S8, and group-specific component (Gc)) in Hasidic and non-Hasidic Ashkenazi New York City Jewish subpopulations. For all loci tested, except HBGG, the 2 subpopulations meet the assumption of Hardy-Weinberg equilibrium. Comparison of various allele and genotype frequencies for the Hasidic and the non-Hasidic groups showed no significant differences. Comparison of the various allele frequencies in the two subpopulations to another Caucasian group revealed significant differences at the HLA-DQA1 and D7S8 loci in the Hasidic group. These frequency data can be used for comparison to other populations and for frequency estimates in DNA profiling.
authors.affiliation: Graduate School and University Center, City University of New York, NY, USA.
authors.forename: I
authors.initials: I
authors.lastname: Medintz
authors.forename: L
authors.initials: L
authors.lastname: Levine
authors.forename: L
authors.initials: L
authors.lastname: McCurdy
authors.forename: L
authors.initials: L
authors.lastname: Chiriboga
authors.forename: C
authors.initials: C
authors.lastname: Kingston
authors.forename: D
authors.initials: D
authors.lastname: Crim
authors.forename: R J
authors.initials: RJ
authors.lastname: Desnick
authors.forename: C M
authors.initials: CM
authors.lastname: Eng
authors.forename: L
authors.initials: L
authors.lastname: Kobilinsky
mesh_terms: D001788:Blood Grouping and Crossmatching; D016009:Chi-Square Distribution; D004247:DNA / Q000097:blood*; D018732:Forensic Anthropology / Q000379:methods; D005784:Gene Amplification; D005787:Gene Frequency; D005819:Genetic Markers; D005838:Genotype; D006683:HLA-DQ Antigens / Q000235:genetics*; D059848:HLA-DQ alpha-Chains; D006801:Humans; D007585:Jews / Q000235:genetics*; D009519:New York City
chemical_list: D005819:Genetic Markers; D006683:HLA-DQ Antigens; D059848:HLA-DQ alpha-Chains; C069050:HLA-DQA1 antigen; D004247:DNA