title: Disappearance of 99mTc-MDP accumulation in metastatic bone disease during bone scintigraphy.
abstract: We describe a patient with progressive metastatic bone disease involving a pedicle of the lumbar spine, in whom serial bone scans were performed. Initially, increased radiotracer accumulation was evident, corresponding to an osteoblastic lesion found on CT. Later, radiotracer uptake appeared to be normal, while an expansile tumor causing osteolytic change was noted on CT. We suggest that false-negative bone scan can occur in the natural process of progressive bone metastasis.
authors.affiliation: Department of Radiology, Sendai City Hospital, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Kinoshita
authors.forename: K
authors.initials: K
authors.lastname: Ishii
authors.forename: Y
authors.initials: Y
authors.lastname: Imai
mesh_terms: D000368:Aged; D005188:False Negative Reactions; D006801:Humans; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging* / Q000473:pathology; D008297:Male; D018215:Osteoblastoma / Q000000981:diagnostic imaging*; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D013125:Spinal Neoplasms / Q000000981:diagnostic imaging* / Q000556:secondary; D013669:Technetium Tc 99m Medronate; D014057:Tomography, X-Ray Computed; D001749:Urinary Bladder Neoplasms / Q000473:pathology*
chemical_list: D019275:Radiopharmaceuticals; D013669:Technetium Tc 99m Medronate