A cisternal maturation mechanism can explain the asymmetry of the Golgi stack.
Morphological data suggest that Golgi cisternae form at the cis-face of the stack and then progressively mature into trans-cisternae. However, other studies indicate that COPI vesicles transport material between Golgi cisternae. These two observations can be reconciled by assuming that cisternae carry secretory cargo through the stack in the anterograde direction, while COPI vesicles transport Golgi enzymes in the retrograde direction. This model provides a mechanism for cisternal maturation. If Golgi enzymes compete with one another for packaging into COPI vesicles, we can account for the asymmetric distribution of enzymes across the stack.
Glick
B S
BS
Department of Molecular Genetics and Cell Biology, The University of Chicago, IL 60637, USA. bsglick@midway.uchicago.edu
Elston
T
T
Oster
G
G
D000818:Animals; D018699:Coated Vesicles / Q000502:physiology / Q000648:ultrastructure; D020756:Coatomer Protein; D004721:Endoplasmic Reticulum / Q000502:physiology / Q000648:ultrastructure; D006056:Golgi Apparatus / Q000201:enzymology / Q000502:physiology* / Q000648:ultrastructure*; D008565:Membrane Proteins / Q000378:metabolism; D008954:Models, Biological; D008961:Models, Structural
D020756:Coatomer Protein; D008565:Membrane Proteins