title: Uptake of In-111 pentetreotide by normally functioning nodular goiters.
abstract: After the intravenous administration of a radiolabeled somatostatin analogue (octreotide), normal thyroid and neoplastic and nonneoplastic thyroid lesions can be visualized. The authors present the cases of two patients who underwent somatostatin receptor scintigraphy (SSRS) using In-111 pentetreotide: one for the study of suspected paraneoplastic ACTH hypersecretion, and the other for a restaging of breast carcinoma with neuroendocrine features. In both patients, SSRS revealed increased uptake in the thyroid, corresponding to "cold" nodules on Tc-99m pertechnetate imaging. Cytologic and histologic examinations showed the typical features of thyroid goiters without lymphocytic infiltration.
authors.affiliation: Nuclear Medicine Service, Ospedale di Circolo, Varese, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Garancini
authors.forename: S
authors.initials: S
authors.lastname: La Rosa
authors.forename: D
authors.initials: D
authors.lastname: De Palma
authors.forename: S
authors.initials: S
authors.lastname: Uccella
authors.forename: F
authors.initials: F
authors.lastname: Golonia
mesh_terms: D000236:Adenoma / Q000000981:diagnostic imaging; D000324:Adrenocorticotropic Hormone / Q000378:metabolism; D001707:Biopsy, Needle; D001943:Breast Neoplasms / Q000000981:diagnostic imaging; D002277:Carcinoma / Q000000981:diagnostic imaging; D005260:Female; D006044:Goiter, Nodular / Q000000981:diagnostic imaging* / Q000473:pathology; D006801:Humans; D007205:Indium Radioisotopes / Q000008:administration & dosage; D007275:Injections, Intravenous; D008875:Middle Aged; D009367:Neoplasm Staging; D018358:Neuroendocrine Tumors / Q000000981:diagnostic imaging; D010257:Paraneoplastic Syndromes / Q000000981:diagnostic imaging; D010911:Pituitary Neoplasms / Q000000981:diagnostic imaging; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000008:administration & dosage; D017481:Receptors, Somatostatin; D013670:Sodium Pertechnetate Tc 99m; D013004:Somatostatin / Q000008:administration & dosage / Q000031:analogs & derivatives*; D013961:Thyroid Gland / Q000000981:diagnostic imaging; D016606:Thyroid Nodule / Q000000981:diagnostic imaging / Q000473:pathology
chemical_list: D007205:Indium Radioisotopes; D019275:Radiopharmaceuticals; D017481:Receptors, Somatostatin; D013004:Somatostatin; D000324:Adrenocorticotropic Hormone; D013670:Sodium Pertechnetate Tc 99m; C081788:pentetreotide