[Gastrinemia and heparin stimulated secretion of diamine oxidase on the course of diabetic autonomic neuropathy].
Gastrin influences polyamine synthesis in the enterocytes, which can lead to increased DAO activity. In diabetics with autonomic neuropathy (AN), a higher than normal gastrin concentration was found. However, in diabetics with enteropathy, a low level of plasma DAO activity was discovered. The purpose of this study was to investigate gastrin secretion and to evaluate DAO activity after i.v. injection of heparin in a group of diabetics with AN. Group I consisted of 12 diabetics with AN, group II 20 patients with diabetes without any complications and group III (the control group) 20 patients without diabetes. It was discovered that basal gastrin concentrations were significantly greater in group I (147 pg/ml +/- 76.5) that in groups II (78 pg/ml +/- 55.5)(p < 0.01) and III (61.5 pg/ml +/- 42.6)(p < 0.01). DAO activity was at its lowest in group I (247.1 pmol/min/ml +/- 104.8) and it was significantly different from group II (441 pmol/min/ml +/- 225.9)(p < 0.001) and III (540.7 pmol/min/ml +/- 171.1)(p < 0.001). There were no differences in the mean values of gastrin and DAO activity between group II and III. In group I low DAO activity was accompanied by a proportionally high concentration of the basal gastrin value (r = 0.567). In conclusion, in diabetics with AN, low postheparin plasma DAO activity was accompanied by a high basal gastrin value.
Loba
J
J
Kliniki Chorób Przewodu Pokarmowego i Przemiany Materii IMW Akademii Medycznej w Lodzi.
Chmielecki
C
C
Brozyński
K
K
D000328:Adult; D006631:Amine Oxidase (Copper-Containing) / Q000097:blood*; D001342:Autonomic Nervous System Diseases / Q000201:enzymology*; D003924:Diabetes Mellitus, Type 2 / Q000201:enzymology; D003929:Diabetic Neuropathies / Q000201:enzymology*; D005260:Female; D005755:Gastrins / Q000187:drug effects* / Q000378:metabolism; D006493:Heparin / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008875:Middle Aged
D005755:Gastrins; D006493:Heparin; D006631:Amine Oxidase (Copper-Containing)