Migratory pulmonary infiltrates in a patient treated with sotalol.
Beta-blockers may induce several types of adverse respiratory reaction such as asthma, interstitial lung disease with or without pleural effusion, systemic lupus erythematosus or hypersensitivity pneumonitis. More recently, bronchiolitis obliterans with organizing pneumonia (BOOP) has been described. We report here on pulmonary migratory infiltrates with combined histopathological features of both BOOP and eosinophilic pneumonia in a woman treated with sotalol long-term. The patient improved only partially with steroids. Tapering off corticosteroid dosage resulted in relapse, and complete recovery was only obtained after sotalol was stopped.
Faller
M
M
Service de Pneumologie, Hôpitaux Universitaires de Strasbourg, France.
Quoix
E
E
Popin
E
E
Gangi
A
A
Gasser
B
B
Mathelin
C
C
Pauli
G
G
D000319:Adrenergic beta-Antagonists / Q000009:adverse effects*; D018549:Cryptogenic Organizing Pneumonia / Q000139:chemically induced / Q000000981:diagnostic imaging / Q000473:pathology; D005260:Female; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging / Q000473:pathology; D008171:Lung Diseases / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000473:pathology; D008875:Middle Aged; D011859:Radiography; D013015:Sotalol / Q000009:adverse effects*
D000319:Adrenergic beta-Antagonists; D013015:Sotalol