title: Neutralising antibody and challenge response to live and inactivated avian adenovirus-1 in broilers.
abstract: Immune responses to live and inactivated avian adenovirus-1 were evaluated in broilers by neutralising antibody response and challenge reaction. The neutralising antibody titre was 1:256, 1:64 and 1:32 in live virus, inactivated virus and uninoculated control birds respectively at 3 weeks post inoculation when they were challenged. At one week post challenge the antibody titres were 1:941, 1:247 and 1:375 in live virus, inactivated virus and control birds, respectively. There was a booster effect of challenge in the live virus inoculated group up to 3 weeks post challenge. The post challenge histopathological evaluation of liver, kidneys, lungs and bursa revealed less severe changes in the live virus inoculated group as compared to other groups.
authors.affiliation: Department of Veterinary Bacteriology and Virology, College of Veterinary Science, Punjab Agricultural University, Ludhiana, India.
authors.forename: A
authors.initials: A
authors.lastname: Kaur
authors.forename: M S
authors.initials: MS
authors.lastname: Oberoi
authors.forename: A
authors.initials: A
authors.lastname: Singh
mesh_terms: D000257:Adenoviridae Infections / Q000276:immunology / Q000517:prevention & control / Q000662:veterinary; D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis* / Q000097:blood; D000259:Aviadenovirus / Q000276:immunology* / Q000302:isolation & purification; D002060:Bursa of Fabricius / Q000473:pathology; D002478:Cells, Cultured; D002642:Chick Embryo / Q000166:cytology / Q000821:virology; D002645:Chickens / Q000276:immunology*; D005260:Female; D007668:Kidney / Q000473:pathology; D008099:Liver / Q000196:embryology / Q000473:pathology / Q000821:virology; D008168:Lung / Q000473:pathology; D008297:Male; D011201:Poultry Diseases / Q000276:immunology / Q000473:pathology / Q000517:prevention & control; D014611:Vaccination / Q000662:veterinary*; D014613:Vaccines, Attenuated / Q000008:administration & dosage / Q000276:immunology; D015164:Vaccines, Inactivated / Q000008:administration & dosage / Q000276:immunology; D014765:Viral Vaccines / Q000008:administration & dosage / Q000276:immunology*
chemical_list: D000914:Antibodies, Viral; D014613:Vaccines, Attenuated; D015164:Vaccines, Inactivated; D014765:Viral Vaccines