Malononitrilamides (MNA 279 and MNA 715) have therapeutic activity in acute and chronic relapsing experimental allergic encephalomyelitis (EAE).
Schorlemmer
H U
HU
Research Laboratories Hoechst Marion Roussell (HMR), Marburg, Germany.
Bartlett
R R
RR
D000208:Acute Disease; D000480:Alkynes; D000818:Animals; D002908:Chronic Disease; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000188:drug therapy*; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D007555:Isoxazoles; D007700:Kinetics; D009570:Nitriles / Q000627:therapeutic use*; D051381:Rats; D011917:Rats, Inbred Lew; D012008:Recurrence
D000480:Alkynes; D007166:Immunosuppressive Agents; D007555:Isoxazoles; D009570:Nitriles; C102911:X 910279; C115284:2-cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)-2-hepten-6-ynamide