[The effect of mexidol on thymus cells in chronic hypokinesia].
The dynamic of mexidol's (3-oxipyridine derivate) influence on rats' thymic cells was studied under the conditions of 30-days hypokinesia. It was shown, that changes of thymic cells' content under the chronic hypokinesia developed in some stages. The prevent administration of mexidol (100 mg/kg of body weight) modified the lymphoid cells' migration. The remedy's effects on quantitative parameters of thymic cell's populations depended on stress stage and were synergic to natural adaptive processes. The most expressed mexidol's normalizing effect on thymic cells was marked on the 30th day of hypokinesia.
Vazhnycha
O M
OM
Dev'iatkina
T O
TO
Kovalenko
E H
EH
D000818:Animals; D001773:Blood Cells / Q000187:drug effects; D001853:Bone Marrow / Q000187:drug effects; D001854:Bone Marrow Cells; D002465:Cell Movement / Q000187:drug effects; D002908:Chronic Disease; D018476:Hypokinesia / Q000473:pathology*; D008297:Male; D010847:Picolines / Q000494:pharmacology*; D011619:Psychotropic Drugs / Q000494:pharmacology*; D051381:Rats; D013154:Spleen / Q000166:cytology / Q000187:drug effects; D013950:Thymus Gland / Q000166:cytology / Q000187:drug effects*; D013997:Time Factors
D010847:Picolines; D011619:Psychotropic Drugs; C070020:emoxypine succinate