Effects of nisoxetine, a selective noradrenaline transporter blocker, on sleep in rats.
Nisoxetine has been shown to block specifically noradrenaline (NA) reuptake. Therefore, this potential antidepressant is a valuable tool for investigating the involvement of the NA system in sleep regulation. This study aimed to investigate the effects of different doses of nisoxetine on sleep parameters in rats. The main effects were observed with the highest dose and concern paradoxical sleep (PS). Indeed, although total sleep time was not modified, PS appeared later and its amount and the number of its episodes were reduced. These changes suggest a critical involvement of NA in the induction of PS.
Python
A
A
Hôpitaux Universitaires de Genève, Belle-Idée, Service de Neuropyschiatrie, Chêne Bourg, Switzerland.
Charnay
Y
Y
Mikolajewski
R
R
Merica
H
H
De Saint Hilaire
Z
Z
D000818:Animals; D002352:Carrier Proteins / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005473:Fluoxetine / Q000031:analogs & derivatives* / Q000494:pharmacology; D008297:Male; D050484:Norepinephrine Plasma Membrane Transport Proteins; D051381:Rats; D017208:Rats, Wistar; D012890:Sleep / Q000187:drug effects*; D027981:Symporters
D002352:Carrier Proteins; D050484:Norepinephrine Plasma Membrane Transport Proteins; C493226:Slc6a2 protein, rat; D027981:Symporters; D005473:Fluoxetine; C011386:nisoxetine