Notch signalling in development: on equivalence groups and asymmetric developmental potential.
Notch-mediated lateral signalling takes place between equivalent cells that then adopt alternative fates. An example is the epidermal-neural choice in the Drosophila neuro-ectoderm. Sometimes this choice is random. Sometimes it is biased to a preferred cell by an extrinsic signal. Sometimes the neural precursor is predetermined. A stochastic outcome is probably older in evolutionary terms.
Simpson
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Institut de Génétique et de Biologie Cellulaire et Moléculaire, CNRS/INSERM/ULP, Illkirch, France. psimpson@igbmc.u-strasbg.fr
D000818:Animals; D019070:Cell Lineage / Q000235:genetics; D004330:Drosophila / Q000166:cytology / Q000196:embryology / Q000235:genetics; D029721:Drosophila Proteins; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism*; D009420:Nervous System / Q000196:embryology; D051880:Receptors, Notch; D015398:Signal Transduction
D029721:Drosophila Proteins; D008565:Membrane Proteins; C497759:N protein, Drosophila; D051880:Receptors, Notch