title: Combination assay for tumor markers in oral squamous cell carcinoma.
abstract: OBJECTIVE
  This study evaluated use of a combination assay of tumor markers in the diagnosis of oral squamous cell carcinoma.
  
  
  METHODS
  Serum levels of four tumor markers (carcinoembryonic antigen [CEA], squamous cell carcinoma antigen [SCCA], immunosuppressive acidic protein [IAP], and cytokeratin 19 fragment [Cyfra]) were simultaneously measured in 42 patients with oral squamous cell carcinoma (O-SCC) and in 12 patients with oral benign diseases.
  
  
  RESULTS
  The positive rates were 31.0% for CEA, 38.1% for SCCA, 52.4% for IAP, and 38.1% for Cyfra in patients with O-SCC. These rates were significantly different (P < .01) from those of control patients with oral benign diseases. The sensitivity (81.0%) and accuracy (77.8%) of the combination assay uses higher than that obtained with individual markers.
  
  
  CONCLUSIONS
  A combination assay with CEA, SCCA, IAP, and Cyfra may be useful for the screening of patients with suspected oral squamous cell carcinoma.
authors.affiliation: Second Department of Oral and Maxillofacial Surgery, Kyushu Dental College, Kitakyushu, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Kurokawa
authors.forename: Y
authors.initials: Y
authors.lastname: Yamashita
authors.forename: S
authors.initials: S
authors.lastname: Tokudome
authors.forename: M
authors.initials: M
authors.lastname: Kajiyama
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000951:Antigens, Neoplasm / Q000097:blood; D014408:Biomarkers, Tumor / Q000097:blood*; D002272:Carcinoembryonic Antigen / Q000097:blood; D002294:Carcinoma, Squamous Cell / Q000097:blood / Q000175:diagnosis*; D016009:Chi-Square Distribution; D005260:Female; D006801:Humans; D007633:Keratins / Q000097:blood; D008297:Male; D008875:Middle Aged; D009059:Mouth Diseases / Q000097:blood / Q000175:diagnosis; D009062:Mouth Neoplasms / Q000097:blood / Q000175:diagnosis*; D009363:Neoplasm Proteins / Q000097:blood; D012680:Sensitivity and Specificity; D015843:Serpins
chemical_list: D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen; D009363:Neoplasm Proteins; D015843:Serpins; C030193:immunosuppressive acidic protein; C051072:squamous cell carcinoma-related antigen; D007633:Keratins