Cervical intraepithelial neoplasia in HIV-infected women in a southeastern US population.
The objectives of our study were to determine the prevalence of cervical intraepithelial neoplasia (CIN) in a southeastern human immunodeficiency virus (HIV)-positive population relative to an HIV-negative control group and to compare these findings with published reports from other geographic regions. Demographic, medical, and cytopathologic data were collected on 89 HIV-positive women receiving care at the Duke Adult Infectious Disease Clinic. Comparisons were made with 100 HIV-negative obstetric patients who delivered at Duke and with published reports from other regions of the United States and abroad. Cervical intraepithelial neoplasia was present in 43 (49%) of 87 HIV-positive women compared with 23% of the 100 HIV-negative patients. Two of the HIV-positive patients had invasive cancer. Comparison of these patients with patients from other geographic regions revealed similar odds ratios for the presence of CIN in HIV-positive patients compared with HIV-negative patients. These results suggest a significantly increased risk for cervical dysplasia in HIV-positive women in this southeastern population.
Drapkin
A L
AL
Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, NC 27710, USA.
Livingston
E G
EG
Dodge
R
R
Coogan
A C
AC
Herbert
W N
WN
D000328:Adult; D000367:Age Factors; D044383:Black People; D018791:CD4 Lymphocyte Count; D016009:Chi-Square Distribution; D005260:Female; D015658:HIV Infections / Q000453:epidemiology*; D018023:HIV Seronegativity; D006801:Humans; D009361:Neoplasm Invasiveness; D016017:Odds Ratio; D010298:Parity; D015995:Prevalence; D012189:Retrospective Studies; D012307:Risk Factors; D012923:Social Class; D015144:Southeastern United States / Q000453:epidemiology; D014481:United States / Q000453:epidemiology; D002578:Uterine Cervical Dysplasia / Q000453:epidemiology / Q000473:pathology; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology* / Q000473:pathology; D044465:White People; D001741:Black or African American