title: c-erbB-2 oncoprotein and epidermal growth factor receptor in cervical lesions.
abstract: Epidermal growth factor receptor (EGF-R) and the oncogene product of c-erbB-2 have been shown to be expressed in human tumors and in some cases relate to clinical outcome. This study investigates the correlation between the presence of these receptor proteins and various histological grades of cervical tissues. Immunocytochemical analysis of benign, premalignant and malignant cervical tissues showed a highly significant correlation between the expression of the two proteins and the histological grade of the lesions. Moreover, the overall frequency of coexpression of these proteins was similar. This study suggests that these proteins may be involved in cellular proliferation and have a significant role in the progression of cervical cancer.
authors.affiliation: Division of Laboratory Medicine, Regional Cancer Center, Thiruvanathapuram, Kerala State, India.
authors.forename: S
authors.initials: S
authors.lastname: Lakshmi
authors.forename: M B
authors.initials: MB
authors.lastname: Nair
authors.forename: P G
authors.initials: PG
authors.lastname: Jayaprakash
authors.forename: T N
authors.initials: TN
authors.lastname: Rajalekshmy
authors.forename: M K
authors.initials: MK
authors.lastname: Nair
authors.forename: M R
authors.initials: MR
authors.lastname: Pillai
mesh_terms: D002278:Carcinoma in Situ / Q000378:metabolism* / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D066246:ErbB Receptors / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000378:metabolism*; D002583:Uterine Cervical Neoplasms / Q000378:metabolism* / Q000473:pathology
chemical_list: D066246:ErbB Receptors; D018719:Erb-b2 Receptor Tyrosine Kinases