Dorsal root repair by means of an autologous nerve graft: experimental study in the rat.
Rat dorsal root regeneration was studied after 6th and 7th cervical root surgical removal and replacement with an autologous graft of peripheral nerve harvested from the surval nerve from dorsal root ganglion to dorsal horn. Histological studies showed axonal regeneration within the grafts. When the distal end of the graft was placed inside the posterior horn of the spinal cord by use of a myelotomy, axonal sprouts (revealed by the transganglionic staining method of horseradish peroxidase or HSP) reached the neurones of the posterior horn in a limited fashion.
Sáiz-Sapena
N
N
Department of Anaesthesiology, Clinica Universitaria, University of Navarra, Pamplona, Spain.
Vanaclocha
V
V
Insausti
R
R
Idoate
M
M
D000818:Animals; D001369:Axons / Q000473:pathology; D005260:Female; D005727:Ganglia, Spinal / Q000473:pathology / Q000601:surgery*; D009416:Nerve Regeneration / Q000502:physiology*; D010525:Peripheral Nerves / Q000473:pathology / Q000637:transplantation*; D051381:Rats; D017208:Rats, Wistar; D013116:Spinal Cord / Q000473:pathology; D013497:Sural Nerve / Q000473:pathology / Q000637:transplantation