title: Apolipoprotein E epsilon2 does not increase risk of early-onset sporadic Alzheimer's disease.
abstract: We examined the association of apolipoprotein E (ApoE) genotype and the risk of early-onset Alzheimer's disease (AD) in 209 white early-onset sporadic cases (43% male) and 303 white controls (48% male) of similar age distribution. The risk of AD was significantly increased, relative to the 3/3 genotype, in people with the 4/4, 3/4, and 2/4 genotypes, controlling for age at time of examination and sex. The 2/3 genotype reduced slightly the risk of AD, although the effect was not statistically significant. We conclude, contrary to some previous reports, that the ApoE epsilon2 allele does not increase the risk of early-onset sporadic AD.
authors.affiliation: Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.
authors.forename: W K
authors.initials: WK
authors.lastname: Scott
authors.forename: A M
authors.initials: AM
authors.lastname: Saunders
authors.forename: P C
authors.initials: PC
authors.lastname: Gaskell
authors.forename: P A
authors.initials: PA
authors.lastname: Locke
authors.forename: J H
authors.initials: JH
authors.lastname: Growdon
authors.forename: L A
authors.initials: LA
authors.lastname: Farrer
authors.forename: S A
authors.initials: SA
authors.lastname: Auerbach
authors.forename: A D
authors.initials: AD
authors.lastname: Roses
authors.forename: J L
authors.initials: JL
authors.lastname: Haines
authors.forename: M A
authors.initials: MA
authors.lastname: Pericak-Vance
mesh_terms: D000328:Adult; D017668:Age of Onset; D000368:Aged; D000483:Alleles; D000544:Alzheimer Disease / Q000235:genetics*; D001057:Apolipoproteins E / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors
chemical_list: D001057:Apolipoproteins E