title: Association between nonadministration of subconjunctival cefuroxime and postoperative endophthalmitis.
abstract: OBJECTIVE
  To determine whether not administering subconjunctival cefuroxime during cataract surgery is associated with postoperative endophthalmitis.
  
  
  METHODS
  Southampton Eye Unit, Southampton General Hospital, England.
  
  
  METHODS
  This retrospective, case-control study comprised nine patients who developed endophthalmitis after cataract surgery in a single ophthalmic unit over a 21 month period. Ten control patients for each case were randomly chosen from patients having cataract surgery within 1 week of the endophthalmitis case.
  
  
  RESULTS
  None of the nine endophthalmitis patients received peroperative subconjunctival cefuroxime compared with 43 of 90 control patients (47.8%) (P = 0.008). No other variables were found to be associated with development of endophthalmitis in this study.
  
  
  CONCLUSIONS
  Nonadministration of subconjunctival cefuroxime was associated with subsequent endophthalmitis. A further study to determine whether the observed association is causal is therefore warranted.
authors.affiliation: Southampton Eye Unit, Southampton General Hospital, England.
authors.forename: O J
authors.initials: OJ
authors.lastname: Lehmann
authors.forename: C J
authors.initials: CJ
authors.lastname: Roberts
authors.forename: K
authors.initials: K
authors.lastname: Ikram
authors.forename: M J
authors.initials: MJ
authors.lastname: Campbell
authors.forename: J I
authors.initials: JI
authors.lastname: McGill
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000867:Anterior Chamber / Q000382:microbiology; D019072:Antibiotic Prophylaxis; D016022:Case-Control Studies; D002387:Cataract Extraction / Q000009:adverse effects*; D002444:Cefuroxime / Q000008:administration & dosage* / Q000627:therapeutic use; D002511:Cephalosporins / Q000008:administration & dosage* / Q000627:therapeutic use; D003228:Conjunctiva; D009877:Endophthalmitis / Q000382:microbiology / Q000517:prevention & control*; D015818:Eye Infections, Bacterial / Q000209:etiology / Q000517:prevention & control*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013203:Staphylococcal Infections / Q000382:microbiology / Q000517:prevention & control*; D013211:Staphylococcus aureus / Q000302:isolation & purification; D014822:Vitreous Body / Q000382:microbiology
chemical_list: D002511:Cephalosporins; D002444:Cefuroxime