The use of Chinese herbal medicine on experimental fracture healing.
The purpose of this study was to examine the effect of Ru-Yih-Jin-Huang-Saan (RYJHS) and Jie-Guu-Saan (JGS) on experimental fracture healing in rats. Seventy-five rats were fractured in the middle of the left tibia and fibula. They were randomly divided into experimental and control groups and injected with Ringer's solution and applied with Ru-Yih-jin-Huang-Saan externally or fed with Jie-Guu-Saan respectively. The animals were sacrificed at 4, 8 and 12 days after fracture. The contents of hydroxyproline and the synthesis of DNA, RNA and protein were observed. The results demonstrate that groups treated with herbal medicine were more rapidly and thoroughly healed than the control group in respect to collagen formation and bone cell metabolism.
Huang
H F
HF
Institute of Chinese Medical Science, China Medical College, Taichung.
You
J S
JS
D000284:Administration, Oral; D000287:Administration, Topical; D000821:Animal Feed; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D003094:Collagen / Q000096:biosynthesis; D004247:DNA / Q000096:biosynthesis; D004195:Disease Models, Animal; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000494:pharmacology*; D017102:Fracture Healing / Q000187:drug effects*; D006909:Hydroxyproline / Q000032:analysis; D012313:RNA / Q000096:biosynthesis; D011897:Random Allocation; D051381:Rats; D013977:Tibia / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D013978:Tibial Fractures / Q000188:drug therapy*
D004365:Drugs, Chinese Herbal; D012313:RNA; D003094:Collagen; D004247:DNA; D006909:Hydroxyproline