Benfluorex, a hypotriglyceridemic drug, reduces lipid peroxidation and alleviates adverse metabolic complications of copper deficiency.
The pathologies associated with copper deficiency in rats fed fructose may be induced, in part, by hypertriglyceridemia and lipid peroxidation. Reducing triacylglycerol levels in plasma may result in lowering lipid peroxidation, which in turn could ameliorate metabolic effects resulting from the combination of fructose feeding and copper deficiency. Benfluorex, a hypolipidemic factor able to reduce hypertriglyceridemia, was administered to weanling male rats fed either copper-deficient (0.6 microgram Cu/g) or adequate (6.0 micrograms Cu/g) diets containing fructose as the sole dietary carbohydrate. In copper-deficient rats, benfluorex (50 micrograms.kg-1.d-1) reduced plasma triacylglycerols from 45 to 31 mg/dL, reduced lipid peroxidation by approximately 50%, and prevented the enlargements of heart and liver size and the atrophy of the pancreas, and ameliorated anemia. It is suggested that lipid peroxidation associated with hypertriglyceridemia may be responsible for the pathologies induced by the combination of fructose consumption and copper deficiency.
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USDA, ARS, Beltsville Human Nutrition Research Center, Metabolism and Nutrient Interactions Laboratory, Beltsville, Maryland 20705, USA.
Lewis
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CG
D000681:Amylases / Q000032:analysis / Q000187:drug effects / Q000378:metabolism; D000704:Analysis of Variance; D000818:Animals; D001835:Body Weight; D015331:Cohort Studies; D003300:Copper / Q000032:analysis / Q000172:deficiency*; D004032:Diet / Q000009:adverse effects; D005215:Fasting; D005277:Fenfluramine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D005632:Fructose / Q000008:administration & dosage / Q000009:adverse effects; D006321:Heart / Q000187:drug effects / Q000502:physiology; D006400:Hematocrit; D015228:Hypertriglyceridemia / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D000960:Hypolipidemic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D007328:Insulin / Q000097:blood / Q000378:metabolism; D007501:Iron / Q000032:analysis; D015227:Lipid Peroxidation / Q000187:drug effects*; D008099:Liver / Q000737:chemistry / Q000187:drug effects / Q000502:physiology; D008297:Male; D009929:Organ Size; D010179:Pancreas / Q000187:drug effects / Q000201:enzymology / Q000502:physiology; D011897:Random Allocation; D051381:Rats; D014280:Triglycerides / Q000097:blood / Q000378:metabolism
D000960:Hypolipidemic Agents; D007328:Insulin; D014280:Triglycerides; D005277:Fenfluramine; D005632:Fructose; C001584:benfluorex; D003300:Copper; D007501:Iron; D000681:Amylases