title: Cyclosporine-related reversible posterior leukoencephalopathy: MRI.
abstract: Three patients aged 48, 11 and 40 years, two of whom were recent recipients of renal transplants and one of a bone marrow transplant, developed seizures, with cortical blindness in two cases. All were immunosuppressed with cyclosporine and were hypertensive at the onset of symptoms. MRI showed predominantly posterior signal changes in all three cases. The abnormalities were more conspicuous on fast FLAIR images than on conventional T2-weighted spin-echo images.
authors.affiliation: Dept. of Neuroimaging, King's College Hospital, London, UK.
authors.forename: J M
authors.initials: JM
authors.lastname: Jarosz
authors.forename: D C
authors.initials: DC
authors.lastname: Howlett
authors.forename: T C
authors.initials: TC
authors.lastname: Cox
authors.forename: J B
authors.initials: JB
authors.lastname: Bingham
mesh_terms: D000328:Adult; D019575:Blindness, Cortical / Q000139:chemically induced / Q000175:diagnosis; D016026:Bone Marrow Transplantation / Q000276:immunology; D002648:Child; D016572:Cyclosporine / Q000008:administration & dosage / Q000009:adverse effects*; D003711:Demyelinating Diseases / Q000139:chemically induced* / Q000175:diagnosis; D005260:Female; D006801:Humans; D007089:Image Enhancement; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000009:adverse effects*; D016030:Kidney Transplantation / Q000276:immunology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000139:chemically induced / Q000175:diagnosis; D012640:Seizures / Q000139:chemically induced / Q000175:diagnosis
chemical_list: D007166:Immunosuppressive Agents; D016572:Cyclosporine