title: Maintenance pharmacological immunosuppressive strategies in renal transplantation.
abstract: Current maintenance immunosuppressive regimens for transplantation are based on three classes of drugs: corticosteroids, immunophilin-binding agents (eg, cyclosporin and tacrolimus), and antimetabolites (eg, azathioprine and mycophenolate). Drugs from the various classes inhibit the immune system at different points and are thus synergistic when used in combination.
authors.affiliation: Department of Medicine, Brigham & Women's Hospital, Boston, MA 02115, USA.
authors.forename: J P
authors.initials: JP
authors.lastname: Vella
authors.forename: M H
authors.initials: MH
authors.lastname: Sayegh
mesh_terms: D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001379:Azathioprine / Q000627:therapeutic use; D016572:Cyclosporine / Q000627:therapeutic use; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D016030:Kidney Transplantation; D009173:Mycophenolic Acid / Q000031:analogs & derivatives / Q000627:therapeutic use; D011090:Polyenes / Q000627:therapeutic use; D011182:Postoperative Care; D020123:Sirolimus; D013256:Steroids; D016559:Tacrolimus / Q000627:therapeutic use
chemical_list: D000893:Anti-Inflammatory Agents; D007166:Immunosuppressive Agents; D011090:Polyenes; D013256:Steroids; D016572:Cyclosporine; D009173:Mycophenolic Acid; D001379:Azathioprine; D020123:Sirolimus; D016559:Tacrolimus