title: Assessment of suspected bone metastases. CT with and without clinical information compared to CT-guided bone biopsy.
abstract: OBJECTIVE
  To evaluate the role of CT with and without clinical information as compared to CT-guided bone biopsy in the assessment of suspected bone metastases.
  
  
  METHODS
  The study comprised 51 consecutive patients with suspected bone metastases who had undergone CT-guided bone biopsies with an eccentric drill system. CT of the targets, clinical information, and histopathology were scored separately as malignant, uncertain or benign. The results of CT alone and CT in combination with clinical information were compared to the results of histopathology.
  
  
  RESULTS
  Histopathology diagnosed 45/51 lesions (88%), 23 as malignant and 22 as benign. CT correctly depicted 17 of these 23 malignant lesions. The remaining 6 malignant lesions were CT-scored as uncertain (n = 5) or benign (n = 1). CT correctly depicted only 3 of the 22 benign lesions. The remaining 19 benign lesions were CT-scored as malignant (n = 2) or uncertain (n = 17). When uncertain CT scores were combined with clinical scores, the true-positive and true-negative results for malignancy increased from 44% to 82%.
  
  
  CONCLUSIONS
  In most cases, CT in combination with clinical information gives enough information about the nature-malignant or benign-of a skeletal lesion. In uncertain cases, diagnostic accuracy can be improved by means of CT-guided bone biopsy.
authors.affiliation: Department of Diagnostic Radiology, Uppsala University Hospital, Sweden.
authors.forename: I
authors.initials: I
authors.lastname: Ciray
authors.forename: G
authors.initials: G
authors.lastname: Aström
authors.forename: C
authors.initials: C
authors.lastname: Sundström
authors.forename: H
authors.initials: H
authors.lastname: Hagberg
authors.forename: H
authors.initials: H
authors.lastname: Ahlström
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy / Q000379:methods / Q000706:statistics & numerical data; D001859:Bone Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology / Q000556:secondary*; D001842:Bone and Bones / Q000000981:diagnostic imaging* / Q000473:pathology*; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012598:Sclerosis; D014057:Tomography, X-Ray Computed / Q000379:methods* / Q000706:statistics & numerical data