title: Recurrence of nonalcoholic steatohepatitis in a liver transplant recipient.
abstract: A 42-year-old white man with morbid obesity and hypertriglyceridemia was noted to have nonalcoholic steatohepatitis (NASH) at the time of a laparoscopic cholecystectomy for presumed gallstone pancreatitis. His postoperative course was complicated by a 50-kg weight loss and continued right upper quadrant pain. Repeat liver biopsy revealed NASH with accompanying micronodular cirrhosis. Due to progressive fatigue, he underwent an orthotopic liver transplantation complicated by a 36-kg weight gain. Sixteen months posttransplantation, a liver biopsy revealed the recurrence of NASH. Screening for defects in fatty acid oxidation proved negative.
authors.affiliation: Department of Medicine, Duke University Medical Center, Durham, NC, USA.
authors.forename: K
authors.initials: K
authors.lastname: Carson
authors.forename: M K
authors.initials: MK
authors.lastname: Washington
authors.forename: W R
authors.initials: WR
authors.lastname: Treem
authors.forename: P A
authors.initials: PA
authors.lastname: Clavien
authors.forename: C M
authors.initials: CM
authors.lastname: Hunt
mesh_terms: D000328:Adult; D001706:Biopsy; D005234:Fatty Liver / Q000150:complications / Q000473:pathology*; D006505:Hepatitis / Q000150:complications / Q000473:pathology*; D006801:Humans; D015228:Hypertriglyceridemia / Q000150:complications; D016031:Liver Transplantation / Q000473:pathology*; D008297:Male; D009765:Obesity / Q000150:complications; D012008:Recurrence