title: Slowing the progression of Alzheimer disease: monitoring progression.
abstract: The search for biologic markers of Alzheimer disease (AD) progression has thus far had limited success. A technique is described, involving magnetic resonance imaging, that can be used to follow the progress of brain atrophy and hence the loss of neuronal tissue. It involves acquisition of three-dimensional images of the brain on two consecutive occasions and their precise co-registration so as to assess the loss of tissue volume over time. Median loss of brain volume in a group of individuals with sporadic and familial AD ranged from about 5-20 ml/year compared to less than 2 ml/year for controls. Loss of cerebral tissue volume was also seen in two individuals from a pedigree with familial AD at a time when symptoms were only just apparent.
authors.affiliation: National Hospital for Neurology and Neurosurgery, London, England.
authors.forename: M N
authors.initials: MN
authors.lastname: Rossor
authors.forename: N C
authors.initials: NC
authors.lastname: Fox
authors.forename: P A
authors.initials: PA
authors.lastname: Freeborough
authors.forename: P K
authors.initials: PK
authors.lastname: Roques
mesh_terms: D000544:Alzheimer Disease / Q000473:pathology*; D001284:Atrophy; D001921:Brain / Q000473:pathology*; D018450:Disease Progression; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*