title: Comparative hemodynamic depression of sevoflurane versus halothane in infants: an echocardiographic study.
abstract: BACKGROUND
  The cardiovascular side effects of volatile anesthetics are one of the chief causes of postoperative complications in children, and infants seem to be at the greatest risk for this. This study compared cardiovascular changes at equipotent concentrations of sevoflurane and halothane in infants.
  
  
  METHODS
  Thirty infants classified as American Society of Anesthesiologists physical status I or II who required elective surgery were randomized to receive either halothane or sevoflurane for inhalation induction. Cardiovascular and echocardiographic data were recorded in both groups at baseline and at end-tidal concentrations of 1 and 1.5 minimum alveolar concentration (MAC).
  
  
  RESULTS
  Sevoflurane did not alter heart rate or cardiac index at all concentrations compared with awake values. Sevoflurane significantly decreased blood pressure and systemic vascular resistance compared with awake values at all concentrations. Shortening fraction and rate-corrected velocity of circumferential fiber shortening decreased at 1.5 but not at 1 MAC. Myocardial contractility assessed by stress-velocity index and stress-shortening index decreased significantly at all concentrations, but did not fall into the abnormal range at any concentration. Halothane caused a greater decrease in heart rate, shortening fraction, stress-shortening index, velocity of circumferential fiber shortening, stress-velocity index, and cardiac index at all concentrations than did sevoflurane.
  
  
  CONCLUSIONS
  Sevoflurane causes a lesser decrease in cardiac output than does halothane in infants.
authors.affiliation: Department of Anesthesiology and Surgical Intensive Care 2, Centre Hospitalier Regional et Universitaire, Rennes, France.
authors.forename: E
authors.initials: E
authors.lastname: Wodey
authors.forename: P
authors.initials: P
authors.lastname: Pladys
authors.forename: C
authors.initials: C
authors.lastname: Copin
authors.forename: M M
authors.initials: MM
authors.lastname: Lucas
authors.forename: A
authors.initials: A
authors.lastname: Chaumont
authors.forename: P
authors.initials: P
authors.lastname: Carre
authors.forename: B
authors.initials: B
authors.lastname: Lelong
authors.forename: O
authors.initials: O
authors.lastname: Azzis
authors.forename: C
authors.initials: C
authors.lastname: Ecoffey
mesh_terms: D018685:Anesthetics, Inhalation / Q000494:pharmacology*; D004452:Echocardiography; D004987:Ethers / Q000494:pharmacology*; D005260:Female; D006221:Halothane / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D007223:Infant; D008297:Male; D008738:Methyl Ethers; D009200:Myocardial Contraction / Q000187:drug effects; D000077149:Sevoflurane
chemical_list: D018685:Anesthetics, Inhalation; D004987:Ethers; D008738:Methyl Ethers; D000077149:Sevoflurane; D006221:Halothane