title: Chemical synthesis of polar zipper peptides: motifs for potential protein association in inherited neurodegenerative diseases.
abstract: Syntheses of peptides containing contiguous repeats of glutamine or asparagine, related to sequences derived from proteins associated with neurodegenerative diseases, are described. Such homo-polymeric peptides are notoriously difficult to prepare due to the formation of aggregated structures during their solid phase synthesis. A novel approach using a randomized array of side chain protected and unprotected residues proved to be an effective strategy for preventing intermolecular peptide-chain association.
authors.affiliation: Medical Research Council, Laboratory of Molecular Biology, Cambridge, England, U.K.
authors.forename: T
authors.initials: T
authors.lastname: Johnson
mesh_terms: D000595:Amino Acid Sequence; D001927:Brain Diseases / Q000235:genetics* / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D005973:Glutamine; D006801:Humans; D006816:Huntington Disease / Q000378:metabolism; D007202:Indicators and Reagents; D017827:Machado-Joseph Disease / Q000378:metabolism; D008969:Molecular Sequence Data; D009136:Muscular Dystrophies / Q000378:metabolism; D009410:Nerve Degeneration / Q000235:genetics* / Q000378:metabolism*; D009419:Nerve Tissue Proteins; D010455:Peptides / Q000138:chemical synthesis / Q000737:chemistry*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D013132:Spinocerebellar Degenerations / Q000378:metabolism
chemical_list: D007202:Indicators and Reagents; D009419:Nerve Tissue Proteins; D010455:Peptides; C095278:atrophin-1; D005973:Glutamine