title: Cisapride use during human pregnancy: a prospective, controlled multicenter study.
abstract: The objective of this prospective multicenter study was to determine whether cisapride is associated with increased risk of malformations, spontaneous abortions, or decreased birthweight when used during pregnancy. Cases were paired for age, smoking, and alcohol consumption with controls exposed to nonteratogens, as well as with disease-paired controls. One hundred and twenty-nine pregnant women were exposed to cisapride during pregnancy, including 88 during the period of fetal organogenesis. There were no differences in maternal history, birthweight, gestational age at delivery, and rates of livebirths, spontaneous or therapeutic abortions, fetal distress, and major or minor malformations among groups. It is concluded that exposure to cisapride during pregnancy is not associated with a major increased risk of malformations or spontaneous abortions or with decreased birthweight.
authors.affiliation: Department of Pediatrics, The Hospital for Sick Children and the University of Toronto, Ontario, Canada.
authors.forename: B
authors.initials: B
authors.lastname: Bailey
authors.forename: A
authors.initials: A
authors.lastname: Addis
authors.forename: A
authors.initials: A
authors.lastname: Lee
authors.forename: K
authors.initials: K
authors.lastname: Sanghvi
authors.forename: P
authors.initials: P
authors.lastname: Mastroiacovo
authors.forename: T
authors.initials: T
authors.lastname: Mazzone
authors.forename: M
authors.initials: M
authors.lastname: Bonati
authors.forename: C
authors.initials: C
authors.lastname: Paolini
authors.forename: H
authors.initials: H
authors.lastname: Garbis
authors.forename: T
authors.initials: T
authors.lastname: Val
authors.forename: C F
authors.initials: CF
authors.lastname: De Souza
authors.forename: D
authors.initials: D
authors.lastname: Matsui
authors.forename: A S
authors.initials: AS
authors.lastname: Schechtman
authors.forename: B
authors.initials: B
authors.lastname: Conover
authors.forename: M
authors.initials: M
authors.lastname: Lau
authors.forename: G
authors.initials: G
authors.lastname: Koren
mesh_terms: D000014:Abnormalities, Drug-Induced / Q000453:epidemiology* / Q000209:etiology; D000022:Abortion, Spontaneous / Q000139:chemically induced*; D000328:Adult; D001724:Birth Weight / Q000187:drug effects*; D016022:Case-Control Studies; D020117:Cisapride; D015331:Cohort Studies; D005260:Female; D005765:Gastrointestinal Agents / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D007231:Infant, Newborn; D010880:Piperidines / Q000009:adverse effects* / Q000627:therapeutic use; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy*; D011446:Prospective Studies; D012307:Risk Factors
chemical_list: D005765:Gastrointestinal Agents; D010880:Piperidines; D020117:Cisapride