title: The prevention of prosthetic infection using a cross-linked albumin coating in a rabbit model.
abstract: We evaluated the effects of a serum protein coating on prosthetic infection in 29 adult male rabbits divided into three groups: control, albumin-coated and uncoated. We used 34 grit-blasted, commercially pure titanium implants. Eleven were coated with cross-linked albumin. All the implants were exposed to a suspension of Staphylococcus epidermidis before implantation. Our findings showed that albumin-coated implants had a much lower infection rate (27%) than the uncoated implants (62%). This may be a useful method of reducing the infection of prostheses.
authors.affiliation: Medical University of South Carolina, Charleston 29425-2239, USA.
authors.forename: Y H
authors.initials: YH
authors.lastname: An
authors.forename: J
authors.initials: J
authors.lastname: Bradley
authors.forename: D L
authors.initials: DL
authors.lastname: Powers
authors.forename: R J
authors.initials: RJ
authors.lastname: Friedman
mesh_terms: D000038:Abscess / Q000473:pathology / Q000517:prevention & control*; D000818:Animals; D018786:Bone Substitutes / Q000009:adverse effects / Q000592:standards*; D004195:Disease Models, Animal; D008297:Male; D008422:Materials Testing; D016459:Prosthesis-Related Infections / Q000473:pathology / Q000517:prevention & control*; D011817:Rabbits; D011897:Random Allocation; D012710:Serum Albumin, Bovine / Q000592:standards*; D013203:Staphylococcal Infections / Q000473:pathology / Q000517:prevention & control*; D013212:Staphylococcus epidermidis; D014025:Titanium / Q000009:adverse effects / Q000592:standards*
chemical_list: D018786:Bone Substitutes; D012710:Serum Albumin, Bovine; D014025:Titanium