Neutrophil antibodies.
Several advances have been made in understanding the polymorphisms of the neutrophil Fc-gamma-receptor IIIb (Fc gamma RIIIb). In one recent study, 21 individuals whose neutrophils lack Fc gamma RIIIb were found to be missing the entire Fc gamma RIIIB and Fc gamma RIIC genes. Another polymorphism of Fc gamma RIIIb, SH, has been characterized. New methods to determine the genotype of Fc gamma RIIIB for NA1, NA2, and SH using leukocyte genomic DNA have been described. A new monoclonal antibody to neutrophil-specific antigen NB1 was produced. Advances have been made in understanding alloimmunization in granulocyte transfusion recipients and the treatment of autoimmune neutropenia with granulocyte colony-stimulating factor (G-CSF). Granulocyte transfusion recipients were found to be alloimmunized both to neutrophil-specific and HLA antigens, suggesting that the transfusion of these patients with granulocytes matched only for HLA antigens will not be effective. A case report suggests that the beneficial effects of G-CSF on patients with autoimmune neutropenia is due in part to G-CSF's action of increasing plasma levels of soluble Fc gamma RIIIb.
Stroncek
D F
DF
National Institutes of Health, Warren G. Magnuson Clinical Center, Department of Transfusion Medicine, Bethesda, MD 20892-1184, USA.
D001327:Autoimmune Diseases / Q000628:therapy; D006098:Granulocytes / Q000276:immunology; D006801:Humans; D007114:Immunization; D007518:Isoantibodies / Q000097:blood*; D007519:Isoantigens / Q000097:blood; D017708:Leukocyte Transfusion; D009503:Neutropenia / Q000276:immunology*; D009504:Neutrophils / Q000276:immunology*
D007518:Isoantibodies; D007519:Isoantigens