title: [Lymphomatoid granulomatosis--remission induction with interferon-alpha 2b].
abstract: METHODS
  A 72-year-old woman was admitted to hospital because of nonproductive cough, acrodistal sensorimotor axonal polyneuropathy, fatigue and 10 kg weight loss over the preceding 9 months.
  
  
  METHODS
  Chest radiogram showed multiple round foci in both lungs. No organs other than the lungs and the peripheral nervous system were affected. Open lung biopsy revealed a pleomorphic angioinvasive lymphocytic infiltrations.
  
  
  METHODS
  The findings indicated lymphomatoid granulomatosis (LG). Wegener granulomatosis was excluded on the basis of the clinical, serological and histopathological findings. Treatment with alpha-interferon (IFN-alpha) produced complete remission within 4 months. Interruption of treatment immediately resulted in a recurrence.
  
  
  CONCLUSIONS
  Together with previously reported cases this patient's response to IFN-alpha suggests that IFN-alpha is a less toxic alternative to cyclophosphamide and corticosteroid administration in the early stages of LG.
authors.affiliation: Poliklinik für Rheumatologie und Rheumaklinik Bad Bramstedt, Institut für Pathologie, Berufsgenossenschaftliche Kliniken Bergmannsheil der Ruhr-Universität, Bochum.
authors.forename: C
authors.initials: C
authors.lastname: Richter
authors.forename: A
authors.initials: A
authors.lastname: Schnabel
authors.forename: K M
authors.initials: KM
authors.lastname: Müller
authors.forename: M
authors.initials: M
authors.lastname: Reuter
authors.forename: P
authors.initials: P
authors.lastname: Schuster
authors.forename: W L
authors.initials: WL
authors.lastname: Gross
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000627:therapeutic use*; D008230:Lymphomatoid Granulomatosis / Q000000981:diagnostic imaging / Q000188:drug therapy*; D013902:Radiography, Thoracic; D011994:Recombinant Proteins; D012074:Remission Induction; D014057:Tomography, X-Ray Computed
chemical_list: D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins