In vivo mutation of the alpha 2A-adrenergic receptor by homologous recombination reveals the role of this receptor subtype in multiple physiological processes.
MacMillan
L B
LB
Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, USA.
Lakhlani
P P
PP
Hein
L
L
Piascik
M
M
Guo
T Z
TZ
Lovinger
D
D
Maze
M
M
Limbird
L E
LE
D000316:Adrenergic alpha-Agonists / Q000494:pharmacology; D000595:Amino Acid Sequence; D019943:Amino Acid Substitution; D000818:Animals; D001216:Asparagine; D001224:Aspartic Acid; D001794:Blood Pressure / Q000187:drug effects; D001921:Brain / Q000378:metabolism*; D002460:Cell Line; D017124:Conserved Sequence; D015536:Down-Regulation; D008125:Locus Coeruleus / Q000502:physiology; D051379:Mice; D008817:Mice, Mutant Strains; D016297:Mutagenesis, Site-Directed; D017354:Point Mutation; D018341:Receptors, Adrenergic, alpha-2 / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology*; D011994:Recombinant Proteins / Q000378:metabolism; D011995:Recombination, Genetic; D014158:Transcription, Genetic
C547769:Adra2a protein, mouse; D000316:Adrenergic alpha-Agonists; D018341:Receptors, Adrenergic, alpha-2; D011994:Recombinant Proteins; D001224:Aspartic Acid; D001216:Asparagine