Remarkable inhibitory effects of hybrid liposomes on the growth of HL-60 cells coupled to induction of apoptosis.
The hybrid liposomes (90 mol% DMPC/10 mol% C12(EO)10 or C12(EO)12) have a highly inhibitory effect on the growth of tumor cells (HL-60). The induction of apoptosis by the hybrid liposomes in HL-60 cells was revealed on the basis of flow cytometry and DNA electrophoresis.
Imamura
C
C
Kumamoto Institute of Technology, Japan.
Kemura
Y
Y
Matsumoto
Y
Y
Ueoka
R
R
D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000633:toxicity; D017209:Apoptosis / Q000187:drug effects*; D016923:Cell Death; D053938:DNA Fragmentation / Q000187:drug effects; D004134:Dimyristoylphosphatidylcholine; D004587:Electrophoresis, Agar Gel; D018922:HL-60 Cells; D006801:Humans; D008081:Liposomes / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D000077423:Polidocanol; D011092:Polyethylene Glycols
D000970:Antineoplastic Agents; D008081:Liposomes; D000077423:Polidocanol; D011092:Polyethylene Glycols; D004134:Dimyristoylphosphatidylcholine