title: General issues of study design and analysis in the use of biomarkers in cancer epidemiology.
abstract: Other contributions to this volume have discussed sources of variation (see Vineis) and measurement error (see White). In this article, we focus on statistical issues involved in the design and analysis of epidemiological studies that use biomarkers. We do not consider statistical issues of laboratory analyses.
authors.affiliation: Wellington Asthma Research Group, Wellington School of Medicine, New Zealand.
authors.forename: N
authors.initials: N
authors.lastname: Pearce
authors.forename: P
authors.initials: P
authors.lastname: Boffetta
mesh_terms: D014408:Biomarkers, Tumor; D003627:Data Interpretation, Statistical; D015340:Epidemiologic Research Design; D006801:Humans; D009369:Neoplasms / Q000453:epidemiology*
chemical_list: D014408:Biomarkers, Tumor