title: A role for the roof plate and its resident TGFbeta-related proteins in neuronal patterning in the dorsal spinal cord.
abstract: Distinct neuronal cell types are generated at characteristic times and positions in the dorsal horn of the spinal cord. We provide evidence that the identity and pattern of generation of dorsal neurons depend initially on BMP-mediated signals that derive from the epidermal ectoderm and induce dorsal midline cells of the roof plate. Roof plate cells provide a secondary source of TGFbeta-related signals that are required for the generation of distinct classes of dorsal interneurons. These inductive interactions involve both qualitative and quantitative differences in signaling by TGFbeta-related factors and temporal changes in the response of neural progenitor cells.
authors.affiliation: Department of Biochemistry and Molecular Biophysics, Center for Neurobiology and Behavior, Columbia University, New York, New York 10032, USA.
authors.forename: K F
authors.initials: KF
authors.lastname: Liem
authors.forename: G
authors.initials: G
authors.lastname: Tremml
authors.forename: T M
authors.initials: TM
authors.lastname: Jessell
mesh_terms: D028341:Activins; D000818:Animals; D015415:Biomarkers; D019521:Body Patterning / Q000235:genetics / Q000502:physiology*; D019485:Bone Morphogenetic Proteins / Q000235:genetics / Q000494:pharmacology / Q000502:physiology*; D002352:Carrier Proteins; D002454:Cell Differentiation; D002642:Chick Embryo; D004475:Ectoderm / Q000502:physiology; D004627:Embryonic Induction / Q000502:physiology; D004817:Epidermis / Q000196:embryology; D038681:Follistatin; D018507:Gene Expression Regulation, Developmental; D006023:Glycoproteins / Q000494:pharmacology; D018398:Homeodomain Proteins / Q000032:analysis; D007265:Inhibins / Q000235:genetics / Q000494:pharmacology; D007395:Interneurons / Q000166:cytology*; D008969:Molecular Sequence Data; D009432:Neural Crest / Q000196:embryology; D009672:Notochord / Q000637:transplantation; D011506:Proteins / Q000494:pharmacology; D051381:Rats; D015398:Signal Transduction / Q000502:physiology; D013116:Spinal Cord / Q000166:cytology / Q000196:embryology*; D016212:Transforming Growth Factor beta / Q000502:physiology*; D000099176:Noggin Protein
chemical_list: D028341:Activins; D015415:Biomarkers; D019485:Bone Morphogenetic Proteins; D002352:Carrier Proteins; D038681:Follistatin; D006023:Glycoproteins; D018398:Homeodomain Proteins; D007265:Inhibins; D011506:Proteins; D016212:Transforming Growth Factor beta; D000099176:Noggin Protein