title: A prospective comparison of high-resolution planar, pinhole, and triple-detector SPECT for the detection of renal cortical defects.
abstract: To compare the detection rate of renal cortical defects with Tc-99m dimercaptosuccinic acid (DMSA) using triple-detector SPECT, pinhole, and planar cortical scintigraphy, the authors prospectively studied 80 kidneys in 40 patients (26 males, 14 females) who ranged in age from 3 months to 26 years (mean: 7.5 years). They found single or multiple definite defects in 30 kidneys using SPECT, 23 using pinhole imaging, and 17 using planar imaging (McNemar's test, two-tailed, P < 0.001 and P = 0.03, respectively). SPECT was significantly better than pinhole imaging at demonstrating definite defects (P = 0.008). This study indicates that SPECT, and to a lesser extent pinhole, are superior to planar imaging for conclusively demonstrating renal cortical defects.
authors.affiliation: Section of Pediatric Radiology, Cleveland Clinic Foundation, OH 44195, USA.
authors.forename: K E
authors.initials: KE
authors.lastname: Applegate
authors.forename: L P
authors.initials: LP
authors.lastname: Connolly
authors.forename: R T
authors.initials: RT
authors.lastname: Davis
authors.forename: D
authors.initials: D
authors.lastname: Zurakowski
authors.forename: S T
authors.initials: ST
authors.lastname: Treves
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007223:Infant; D007672:Kidney Cortex / Q000002:abnormalities / Q000000981:diagnostic imaging*; D007674:Kidney Diseases / Q000000981:diagnostic imaging; D008297:Male; D011446:Prospective Studies; D019275:Radiopharmaceuticals; D012680:Sensitivity and Specificity; D019783:Technetium Tc 99m Dimercaptosuccinic Acid; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*
chemical_list: D019275:Radiopharmaceuticals; D019783:Technetium Tc 99m Dimercaptosuccinic Acid