[Role of inducible nitric oxide synthase in acute gastric mucosal damage in stress, in rats].
In groups of female Wistar rats, someted to stress by immobilization and immersion in 18 degrees C water during 6 hrs, the role of nitric oxide (NO) in its pathophysiologic was studied. Agonist and antagonist of the isoforms Constitutive NO Synthase (cNOS) and of the inducible NO Synthase (iNOS) were used. Was found that the overdose of L-arginine aggravated of stress acute gastric lesions. The agonist of iNOS the NMDA and the antagonists dexamethasone and aminoguanidine were used. The NMDA aggravated the stress acute gastric lesions; in contrast, dexamethasone and aminoguanidine given a evident protection of the gastric mucosa in stress. Was concluded that the production of NO given by iNOS, play a role important in the pathophysiologic in stress acute gastric lesions.
Laudanno
O M
OM
Cátedras de Gastroenterología y de Histología, Facultad de Ciencias Médicas de Rosario, Argentina.
Cesolari
J A
JA
San Miguel
P
P
Bedini
O A
OA
D000208:Acute Disease; D000818:Animals; D003907:Dexamethasone / Q000494:pharmacology; D018690:Excitatory Amino Acid Agonists / Q000494:pharmacology; D005260:Female; D005753:Gastric Mucosa / Q000201:enzymology* / Q000473:pathology / Q000503:physiopathology; D006146:Guanidines / Q000494:pharmacology; D016202:N-Methylaspartate / Q000494:pharmacology; D009569:Nitric Oxide / Q000502:physiology*; D019001:Nitric Oxide Synthase / Q000502:physiology*; D052247:Nitric Oxide Synthase Type II; D051381:Rats; D017208:Rats, Wistar; D018709:Statistics, Nonparametric; D013312:Stress, Physiological / Q000378:metabolism*
D018690:Excitatory Amino Acid Agonists; D006146:Guanidines; D009569:Nitric Oxide; D016202:N-Methylaspartate; D003907:Dexamethasone; D019001:Nitric Oxide Synthase; D052247:Nitric Oxide Synthase Type II; C496318:Nos2 protein, rat; C004479:pimagedine