title: Effect of selected triterpenoids on chronic dermal inflammation.
abstract: The activity of four natural triterpenoids on a 12-O-tetradecanoylphorbol-13-acetate multiple-dose model of skin chronic inflammation was studied. Erythrodiol and ursolic acid were significantly effective. The most important features concerning structure-activity relationship and previous data on the effect of these triterpenoids on other inflammatory conditions are discussed.
authors.affiliation: Departament de Farmacologia, Universitat de València, Spain.
authors.forename: S
authors.initials: S
authors.lastname: Máñez
authors.forename: M C
authors.initials: MC
authors.lastname: Recio
authors.forename: R M
authors.initials: RM
authors.lastname: Giner
authors.forename: J L
authors.initials: JL
authors.lastname: Ríos
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D003877:Dermatitis, Contact / Q000188:drug therapy*; D003907:Dexamethasone / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical; D005260:Female; D051379:Mice; D009828:Oleanolic Acid / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology; D053978:Pentacyclic Triterpenes; D013755:Tetradecanoylphorbol Acetate; D014315:Triterpenes / Q000737:chemistry / Q000494:pharmacology*; D000094062:Betulinic Acid; D000097245:Ursolic Acid
chemical_list: D000893:Anti-Inflammatory Agents; D003907:Dexamethasone; D009828:Oleanolic Acid; D053978:Pentacyclic Triterpenes; D013755:Tetradecanoylphorbol Acetate; D014315:Triterpenes; D000094062:Betulinic Acid; D000097245:Ursolic Acid; C077953:erythrodiol; C002503:betulin