Progressive vaccinia treated with ribavirin and vaccinia immune globulin.
A 67-year-old man with metastatic melanoma and chronic lymphocytic leukemia was inadvertently given a vaccinia melanoma oncolysate vaccination. He developed progressive vaccinia at the site of inoculation. The lesion started to heal only when he was treated with ribavirin. Vaccinia immune globulin was administered and appeared to help control the initial lesion and limit the development of satellite lesions.
Kesson
A M
AM
Discipline of Pathology, University of Newcastle, New South Wales, Australia.
Ferguson
J K
JK
Rawlinson
W D
WD
Cunningham
A L
AL
D000368:Aged; D000914:Antibodies, Viral / Q000008:administration & dosage / Q000627:therapeutic use*; D000998:Antiviral Agents / Q000627:therapeutic use*; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000150:complications; D008297:Male; D008545:Melanoma / Q000150:complications; D012254:Ribavirin / Q000627:therapeutic use*; D012878:Skin Neoplasms / Q000150:complications; D014611:Vaccination; D014615:Vaccinia / Q000188:drug therapy* / Q000821:virology
D000914:Antibodies, Viral; D000998:Antiviral Agents; D012254:Ribavirin