title: Human African trypanosomiasis: MRI.
abstract: We report a case of human African trypanosomiasis caused by Trypanosoma brucei rhodesiense. After the febrile period of parasite dissemination, the patient had meningeal involvement but normal CT. MRI showed the appearances of meningitis. After two periods of arsenical treatment, a severe encephalopathy occurred suggesting post-therapeutic reactive encephalitis (PTRE). Nevertheless, T2-weighted MRI showed no oedema, but focal bilateral high signal areas in the white matter. PTRE was excluded and a third course of treatment was undertaken. The lesions progressively disappeared.
authors.affiliation: Department of Infectious and Tropical Diseases, HIA LAVERAN, Marseille Armées, France. sabbherv@mail.pf
authors.forename: P
authors.initials: P
authors.lastname: Sabbah
authors.forename: C
authors.initials: C
authors.lastname: Brosset
authors.forename: P
authors.initials: P
authors.lastname: Imbert
authors.forename: G
authors.initials: G
authors.lastname: Bonardel
authors.forename: P
authors.initials: P
authors.lastname: Jeandel
authors.forename: J F
authors.initials: JF
authors.lastname: Briant
mesh_terms: D000328:Adult; D000818:Animals; D001921:Brain / Q000473:pathology; D004359:Drug Therapy, Combination; D004660:Encephalitis / Q000175:diagnosis* / Q000188:drug therapy; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008549:Melarsoprol / Q000008:administration & dosage; D008581:Meningitis / Q000175:diagnosis* / Q000188:drug therapy; D011239:Prednisolone / Q000008:administration & dosage; D014057:Tomography, X-Ray Computed; D016833:Trypanosoma brucei rhodesiense / Q000187:drug effects; D014353:Trypanosomiasis, African / Q000175:diagnosis* / Q000188:drug therapy
chemical_list: D011239:Prednisolone; D008549:Melarsoprol