title: Effects of topical otic preparations on hearing in chronic otitis media.
abstract: Most of the topical otic preparations have been shown to cause ototoxicity. In this study ciprofloxacin hydrochloride, a relatively new topical agent, and gentamicin sulfate were studied in two groups of 20 patients with chronic otitis media. Patients were randomly selected to receive either ciprofloxacin (200 microg/ml) or gentamicin sulfate (5 mg/ml) locally, five drops three times a day for 10 days. Clinical response was seen in 20 of 20 patients in the ciprofloxacin group compared with 6 of 20 patients in the gentamicin group. Audiometric evaluation revealed no significant ototoxic effect in either group. In fact, hearing thresholds were slightly better than pretreatment levels in both groups.
authors.affiliation: Department of ENT, Faculty of Medicine, Marmara University, Istanbul, Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Ozagar
authors.forename: A
authors.initials: A
authors.lastname: Koç
authors.forename: A
authors.initials: A
authors.lastname: Ciprut
authors.forename: A
authors.initials: A
authors.lastname: Tutkun
authors.forename: F
authors.initials: F
authors.lastname: Akdaş
authors.forename: M A
authors.initials: MA
authors.lastname: Sehitoğlu
mesh_terms: D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001309:Auditory Threshold; D002648:Child; D002908:Chronic Disease; D002939:Ciprofloxacin / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D005839:Gentamicins / Q000008:administration & dosage / Q000627:therapeutic use*; D006309:Hearing / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D010034:Otitis Media with Effusion / Q000188:drug therapy* / Q000503:physiopathology
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D005839:Gentamicins; D002939:Ciprofloxacin