title: The rules of drug taking: wine and poppy derivatives in the Ancient World. VIII. Lack of evidence of opium addiction.
abstract: The widespread therapeutic use of opium and its probable ritual use is faced with the absence of any explicit description of cases of opium dependence. It is possible that this was due to a lack of diagnostic capability. However, even the attempt to uncover cases of opium dependence by systematically analyzing the literary passages in which poppies, opium, and meconium are quoted are unsuccessful. The only two cases of suspected opium addiction that can be selected in this way are those of the Emperor Marcus Aurelius and Ovid. The most parsimonious interpretation is the lack of an hedonic use of poppy derivatives, being that this kind of use is the most frequently connected with the development of addiction.
authors.affiliation: Institute of Medical Pharmacology, University of Rome La Sapienza, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Nencini
mesh_terms: D018436:Ancient Lands; D049690:History, Ancient; D006801:Humans; D009293:Opioid-Related Disorders / Q000266:history*; D009892:Opium / Q000266:history*
chemical_list: D009892:Opium