Microbial transformation of sclareolide.
The microbial transformation of sclareolide (1) by Curvularia lunata afforded five oxidized metabolites identified as 3-ketosclareolide (2), 1 beta-hydroxysclareolide (3), 3 beta-hydroxysclareolide (4), 1 alpha,3 beta-dihydroxysclareolide (5), and 1 beta, 3 beta-dihydroxysclareolide (6). Fermentations of 1 with Aspergillus niger also produced metabolites 2-6. Metabolites 2-5 were obtained by fermention with Gibberella fujikuroii, while fermentation with Fusarium lini afforded metabolites 4 and 5.
Atta-ur-Rahman
H. E. J. Research Institute of Chemistry, University of Karachi, Pakistan.
Farooq
A
A
Choudhary
M I
MI
D000363:Agaricales / Q000378:metabolism; D001234:Aspergillus niger / Q000378:metabolism; D001711:Biotransformation; D003470:Culture Media / Q000032:analysis; D004224:Diterpenes / Q000378:metabolism*; D005285:Fermentation; D005658:Fungi / Q000378:metabolism*; D005670:Fusarium / Q000378:metabolism; D005874:Gibberella / Q000378:metabolism; D003904:Mitosporic Fungi / Q000378:metabolism
D003470:Culture Media; D004224:Diterpenes; C109395:sclareolide