title: [MR tomographic temperature quantification at 1.5 T in vitro: a comparison of fast T1 maps and a phase-sensitive sequence].
abstract: OBJECTIVE
  To determine the value of fast T1-maps and a phase-sensitive sequence for temperature quantification with MR imaging.
  
  
  METHODS
  The experimental setup allowed both homogeneous heating as well as laser-induced interstitial thermotherapy (Nd:YAG, 1064 nm) of tissue specimens (pig brain, liver and muscle) in vitro. A total of 60 experiments were performed. T1-maps were calculated by means of a multi-point-turbo-FLASH sequence. Additionally, the temperature dependent phase shift was determined with a 2D-FLASH sequence.
  
  
  RESULTS
  The T1-relaxation times of four different aqueous solutions of gadolinium-DTPA (0.125-1.0 mmol/l) varied by less than 5%. During homogeneous heating, the T1-maps revealed a linear correlation (r > 0.98) between temperature and T1-relaxation times. The temperature coefficients were 11.0 +/- 0.42 ms/degree C. Variations of the linear correlation were observed during laser irradiation. There was only slight variation of the temperature coefficients of the chemical shift during homogeneous heating of different tissues (brain: 0.0098 +/- 0.0002 ppm/degree C; muscle: 0.0109 +/- 0.0003 ppm/degree C; liver: 0.0093 +/- 0.0002 ppm/degree C). The temperatures calculated during laser therapy based on the phase shift correlated strongly (r = 0.99) to the measured temperatures.
  
  
  CONCLUSIONS
  Due to the considerable tissue independence and high accuracy, the phase mapping method is superior to T1-maps for monitoring thermal therapy modalities at 1.5 T in vitro.
authors.affiliation: Institut für Diagnostische Radiologie, Heinrich-Heine-Universität, Düsseldorf.
authors.forename: T
authors.initials: T
authors.lastname: Kahn
authors.forename: T
authors.initials: T
authors.lastname: Harth
authors.forename: B
authors.initials: B
authors.lastname: Schwabe
authors.forename: H J
authors.initials: HJ
authors.lastname: Schwarzmaier
authors.forename: U
authors.initials: U
authors.lastname: Mödder
mesh_terms: D000818:Animals; D001921:Brain / Q000033:anatomy & histology; D003287:Contrast Media; D005682:Gadolinium; D019786:Gadolinium DTPA; D006801:Humans; D066298:In Vitro Techniques; D053685:Laser Therapy; D008099:Liver / Q000033:anatomy & histology; D008279:Magnetic Resonance Imaging / Q000295:instrumentation / Q000379:methods*; D009132:Muscles / Q000033:anatomy & histology; D009942:Organometallic Compounds; D004369:Pentetic Acid / Q000031:analogs & derivatives; D019047:Phantoms, Imaging; D013552:Swine; D013696:Temperature; D013821:Thermometers; D013997:Time Factors
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; D004369:Pentetic Acid; D005682:Gadolinium; D019786:Gadolinium DTPA