title: Massive uncomplicated vascular immune complex deposits in the kidney of a patient with systemic lupus erythematosus.
abstract: The case of a patient with systemic lupus erythematosus (SLE) is reported which was accompanied by renal dysfunction and massive vascular immune deposits in the kidney without active glomerular lesions. The renal biopsy showed arterioles and small arteries with circumferential periodic acid-Schiff (PAS) and Masson trichrome-positive homogenous material in the subendothelial area in the absence of thrombotic, necrotizing or inflammatory lesions. Immunofluorescence and electron microscopy examination demonstrated immune deposits in the vascular walls. Glomeruli showed only minor abnormalities with a trend to collapse. There was no improvement in renal dysfunction over a 4-year period until the patient's death, despite steroid therapy producing a decrease in disease activity. The autopsy showed similar vascular changes to those seen in the biopsy, however; glomeruli were either sclerotic or showed a trend to collapse. Massive uncomplicated vascular immune complex deposition without active glomerular lesions is rare. The present case indicates that this type of lupus vasculopathy may be a prognostic factor for the loss of renal function in SLE mediated by hemodynamic glomerular injury.
authors.affiliation: Second Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Takazoe
authors.forename: T
authors.initials: T
authors.lastname: Shimada
authors.forename: H
authors.initials: H
authors.lastname: Nakano
authors.forename: T
authors.initials: T
authors.lastname: Kawamura
authors.forename: Y
authors.initials: Y
authors.lastname: Utsunomiya
authors.forename: T
authors.initials: T
authors.lastname: Kanai
authors.forename: T
authors.initials: T
authors.lastname: Kitajima
authors.forename: Y
authors.initials: Y
authors.lastname: Yamaguchi
authors.forename: K
authors.initials: K
authors.lastname: Joh
authors.forename: T
authors.initials: T
authors.lastname: Mitarai
authors.forename: O
authors.initials: O
authors.lastname: Sakai
mesh_terms: D000368:Aged; D000936:Antigen-Antibody Complex / Q000276:immunology*; D001160:Arterioles / Q000276:immunology / Q000648:ultrastructure; D001706:Biopsy; D005260:Female; D006801:Humans; D007678:Kidney Glomerulus / Q000276:immunology* / Q000648:ultrastructure; D008181:Lupus Nephritis / Q000276:immunology* / Q000473:pathology; D012077:Renal Artery / Q000276:immunology / Q000648:ultrastructure
chemical_list: D000936:Antigen-Antibody Complex