title: An unusual case of severe combined immunodeficiency with hypereosinophilia.
abstract: Investigation of the cytokine profile in a 26-year-old man, suffering from combined immunodeficiency with hypereosinophilia, revealed high levels of interleukin-4 and interleukin-5 and relatively low levels of interleukin-2 and interferon gamma, consistent with a T-helper type 2 pattern, as has been reported in Omenn's syndrome. However, some distinct clinical and immunological features suggest that this case may represent a unique disease with specific pathogenesis.
authors.affiliation: Department of Internal Medicine, University Hospital Nijmegen, The Netherlands. E.Dams@nugen@azn.nl
authors.forename: E T
authors.initials: ET
authors.lastname: Dams
authors.forename: F
authors.initials: F
authors.lastname: Mascart-Lemone
authors.forename: L
authors.initials: L
authors.lastname: Schandené
authors.forename: J W
authors.initials: JW
authors.lastname: van der Meer
mesh_terms: D000328:Adult; D016207:Cytokines / Q000097:blood; D003937:Diagnosis, Differential; D004802:Eosinophilia / Q000150:complications* / Q000276:immunology; D006801:Humans; D008297:Male; D016511:Severe Combined Immunodeficiency / Q000150:complications* / Q000175:diagnosis / Q000276:immunology; D013577:Syndrome
chemical_list: D016207:Cytokines