Genomic structure of the human PLCD1 (phospholipase C delta 1) locus on 3p22-->p21.3.
A large-scale sequencing analysis of genomic DNA in the vicinity of homozygous deletion on chromosome 3p found in a lung cancer cell line disclosed that the gene encoding phospholipase C delta 1 (PLCD1) is located just distal to the region removed by the deletion We report the genomic structure of this gene, which consists of 15 exons and spans about 22 kb, and its precise localization to chromosome 3p22-->p21.3.
Ishikawa
S
S
Laboratory of Molecular Medicine, Institute of Medical Science, University of Tokyo, Japan.
Takahashi
T
T
Ogawa
M
M
Nakamura
Y
Y
D017398:Alternative Splicing / Q000235:genetics; D002893:Chromosomes, Human, Pair 3; D004252:DNA Mutational Analysis; D005091:Exons / Q000235:genetics; D015894:Genome, Human; D006801:Humans; D007438:Introns / Q000235:genetics; D007527:Isoenzymes / Q000235:genetics*; D008175:Lung Neoplasms / Q000235:genetics*; D054803:Phospholipase C delta; D014407:Tumor Cells, Cultured; D010738:Type C Phospholipases / Q000235:genetics*
D007527:Isoenzymes; D010738:Type C Phospholipases; C518024:PLCD1 protein, human; D054803:Phospholipase C delta