title: [A case of multiple muscular abscesses of the lower limbs by Staphylococcus aureus after chemotherapy for lung cancer].
abstract: A 67-year-old male was admitted to our hospital because of lung cancer and interstitial pneumonia. Cisplatin, vindesie and mitomycin C were administered for treatment of lung cancer. The leucocyte-counts declined to 1700/microliter on the eighth day after the chemotherapy. Though granulocyte colony-stimulating factor was administered, pain in the right thigh and high grade fever developed. Because Staphylococcus aureus was isolated from the blood specimen, piperacillin was administered. But the high grade fever continued and the pain was expanded to the right hip, left hip, thigh and leg. Because a computed tomograph of the lower limbs showed low density areas in bilateral gluteus maximus muscle right adductor magnus muscle, left biceps femoris muscle and left soleus muscle and the culture of an aspirate from abscess of right leg detected S. aureus, multiple muscular abscesses of the lower limbs was confirmed. We changed the antibiotics from PIPC to imipenem/cilastatin and minocycline on nineteenth day after the chemotherapy. His symptoms improved after the change of antibacterial agents. But he died of acute exacerbation of interstitial pneumonia, after about two months of the chemotherapy. Muscular abscesses of the limbs are very rare in Japan. Only four cases with muscular abscess of the limbs were reported in Japan, since 1988. This case suggests that a muscular abscess must be considered in the differential diagnosis of fever in patients with neutropenia.
authors.affiliation: Internal Medicine II, Nara Medical University, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Teramoto
authors.forename: M
authors.initials: M
authors.lastname: Konishi
authors.forename: K
authors.initials: K
authors.lastname: Mikasa
authors.forename: K
authors.initials: K
authors.lastname: Hamada
authors.forename: K
authors.initials: K
authors.lastname: Maeda
authors.forename: M
authors.initials: M
authors.lastname: Sakamoto
authors.forename: M
authors.initials: M
authors.lastname: Tsujimoto
authors.forename: K
authors.initials: K
authors.lastname: Mori
authors.forename: K
authors.initials: K
authors.lastname: Ueda
authors.forename: R
authors.initials: R
authors.lastname: Sano
authors.forename: T
authors.initials: T
authors.lastname: Masutani
authors.forename: M
authors.initials: M
authors.lastname: Sawaki
authors.forename: N
authors.initials: N
authors.lastname: Narita
mesh_terms: D000038:Abscess / Q000382:microbiology*; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D006801:Humans; D007866:Leg; D008175:Lung Neoplasms / Q000150:complications / Q000188:drug therapy*; D008297:Male; D009135:Muscular Diseases / Q000382:microbiology*; D009503:Neutropenia / Q000139:chemically induced / Q000150:complications*; D013203:Staphylococcal Infections / Q000209:etiology*