Alterations in gene expression associated with primary demyelination and remyelination in the peripheral nervous system.
Primary demyelination is an important component of a number of human diseases and toxic neuropathies. Animal models of primary demyelination are useful for isolating processes involved in myelin breakdown and remyelination because the complicating events associated with axonal degeneration and regeneration are not present. The tellurium neuropathy model has proven especially useful in this respect. Tellurium specifically blocks synthesis of cholesterol, a major component of PNS myelin. The resulting cholesterol deficit in myelin-producing Schwann cells rapidly leads to sychronous primary demyelination of the sciatic nerve, which is followed by rapid synchronous remyelination when tellurium exposure is discontinued. Known alterations in gene expression for myelin proteins and for other proteins involved in the sequence of events associated with demyelination and subsequent remyelination in the PNS are reviewed, and new data regarding gene expression changes during tellurium neuropathy are presented and discussed.
Toews
A D
AD
Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill 27599, USA. ARREL@CSS.UNC.EDU
Hostettler
J
J
Barrett
C
C
Morell
P
P
D000818:Animals; D003711:Demyelinating Diseases / Q000139:chemically induced / Q000503:physiopathology*; D004195:Disease Models, Animal; D005786:Gene Expression Regulation; D006801:Humans; D008264:Macrophages / Q000502:physiology; D009185:Myelin Proteins / Q000096:biosynthesis / Q000235:genetics*; D009186:Myelin Sheath / Q000502:physiology; D017933:Peripheral Nervous System / Q000503:physiopathology*; D012333:RNA, Messenger / Q000378:metabolism; D013691:Tellurium
D009185:Myelin Proteins; D012333:RNA, Messenger; D013691:Tellurium