title: Plakinidine D, a new pyrroloacridine alkaloid from two ascidians of the genus Didemnum.
abstract: A previously undescribed red Didemnum sp. collected in Indonesia contained a novel pyrroloacridine, plakinidine D (4), along with the known compounds 3,5-diiodo-4-methoxyphenethylamine (5) and ascididemin (6), both of which had previously been isolated from ascidians of the genus Didemnum. Plakinidine D (4) and 3,5-diiodo-4-methoxyphenethylamine (5) were also isolated from Didemnum rubeum from the Republic of Palau. Interestingly, a collection of D. rubeum from Indonesia did not contain plakinidine D (4), but instead contained 3,5-diiodo-4-methoxyphenethylamine (5) and ascididemin (6). The structure of plakinidine D (4) was elucidated by analysis of its spectral data. Plakinidine D (4) is closely related to plakinidines A-C (1-3), previously isolated from the sponge Plakortis sp.
authors.affiliation: Department of Medicinal Chemistry, University of Utah, Salt Lake City 84112, USA.
authors.forename: C J
authors.initials: CJ
authors.lastname: Smith
authors.forename: D A
authors.initials: DA
authors.lastname: Venables
authors.forename: C
authors.initials: C
authors.lastname: Hopmann
authors.forename: C E
authors.initials: CE
authors.lastname: Salomon
authors.forename: J
authors.initials: J
authors.lastname: Jompa
authors.forename: A
authors.initials: A
authors.lastname: Tahir
authors.forename: D J
authors.initials: DJ
authors.lastname: Faulkner
authors.forename: C M
authors.initials: CM
authors.lastname: Ireland
mesh_terms: D000470:Alkaloids / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D000970:Antineoplastic Agents / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared; D014407:Tumor Cells, Cultured; D014561:Urochordata / Q000737:chemistry*
chemical_list: D000470:Alkaloids; D000970:Antineoplastic Agents; C109396:plakinidine D