Brazilin modulates immune function mainly by augmenting T cell activity in halothane administered mice.
Previously we reported that brazilin, the main principle of Caesalpinia sappan, was able to improve the altered immune functions caused by halothane administration in mice. To elucidate the mechanisms of its immunomodulating activities, the effects of brazilin on the functions of T cells and splenic cellularity were investigated. Brazilin decreased splenic cellularity and IL-2 production which had been augmented in mice treated with halothane (21.5% in olive oil, 10 mmol/kg) for 4 consecutive days whereas the reduced expression of IL-2 receptors by ConA or standard IL-2 was increased by brazilin treatment. These data indicate that halothane induced a dysfunction of T cells resulting in abnormal immune responses and these altered immune functions might be improved mainly by affecting the function of T cells.
Choi
S Y
SY
College of Pharmacy, Seoul National University, Korea.
Yang
K M
KM
Jeon
S D
SD
Kim
J H
JH
Khil
L Y
LY
Chang
T S
TS
Moon
C K
CK
D000818:Animals; D001578:Benzopyrans / Q000494:pharmacology*; D002478:Cells, Cultured; D003208:Concanavalin A / Q000494:pharmacology; D007887:Fabaceae; D005260:Female; D006221:Halothane / Q000494:pharmacology*; D007376:Interleukin-2 / Q000096:biosynthesis / Q000494:pharmacology; D008213:Lymphocyte Activation / Q000187:drug effects*; D051379:Mice; D008810:Mice, Inbred C57BL; D037121:Plant Lectins; D010946:Plants, Medicinal; D015375:Receptors, Interleukin-2 / Q000096:biosynthesis; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000187:drug effects* / Q000276:immunology
D001578:Benzopyrans; D007376:Interleukin-2; D037121:Plant Lectins; D015375:Receptors, Interleukin-2; D003208:Concanavalin A; C044362:brazilin; D006221:Halothane