title: Complications experienced with central venous catheters in children with congenital bleeding disorders.
abstract: The use of central venous catheters (CVC) in children with coagulation disorders allows home treatment, the use of prophylactic blood product replacement and induction of immune tolerance. Previous reports have suggested an almost complete lack of infective complications in this patient group. We reviewed 2 3 patients with bleeding disorders who have had 32 CVC inserted at this institution with a median follow-up of 27 months (range 1-92 months). There were 25 documented line-associated infections, including two subcutaneous infections at the port site, and 23 bacteraemias (one episode per 26 patient months at risk). There were 15 Gram-positive, nine Gram-negative and one mixed infection. Infections occurred in 48% of the patients. 15 CVCs were removed: one for erosion through the skin, two for line blockage and 12 for infection. Five patients with inhibitors to factor VIII suffered 14 infections in 12 lines (one per 8.3 months) whereas the 18 without inhibitors suffered 11 infections in 20 lines (one per 50 months) (P<0.03). The use of CVCs is favoured by families of children with bleeding disorders in spite of these complications, but close liaison between families and experienced staff at a Haemophilia Centre is essential to ensure that patients gain the benefits of a CVC as safely as possible.
authors.affiliation: The Haemophilia Comprehensive Care Centre, Great Ormond Street Hospital for Children NHS Trust, London.
authors.forename: P W
authors.initials: PW
authors.lastname: Collins
authors.forename: K S
authors.initials: KS
authors.lastname: Khair
authors.forename: R
authors.initials: R
authors.lastname: Liesner
authors.forename: I M
authors.initials: IM
authors.lastname: Hann
mesh_terms: D001424:Bacterial Infections / Q000209:etiology*; D001778:Blood Coagulation Disorders / Q000151:congenital / Q000628:therapy*; D001803:Blood Transfusion; D002405:Catheterization, Central Venous / Q000009:adverse effects*; D002675:Child, Preschool; D006467:Hemophilia A; D006801:Humans; D007223:Infant; D012307:Risk Factors