title: Examination of ligand-induced conformational changes in the beta 2-adrenergic receptor by fluorescence spectroscopy.
authors.affiliation: Division of Cardiovascular Medicine, Howard Hughes Medical Institute, Stanford University Medical School, California 94305, USA.
authors.forename: B K
authors.initials: BK
authors.lastname: Kobilka
authors.forename: U
authors.initials: U
authors.lastname: Gether
mesh_terms: D000262:Adenylyl Cyclases / Q000378:metabolism; D000318:Adrenergic beta-Agonists / Q000494:pharmacology; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000818:Animals; D002460:Cell Line; D003545:Cysteine; D004837:Epinephrine / Q000494:pharmacology*; D005456:Fluorescent Dyes; D007545:Isoproterenol / Q000494:pharmacology*; D008024:Ligands; D016296:Mutagenesis; D010069:Oxadiazoles; D011412:Propanolamines / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D011487:Protein Conformation / Q000187:drug effects; D018343:Receptors, Adrenergic, beta-2 / Q000096:biosynthesis / Q000737:chemistry* / Q000187:drug effects; D011994:Recombinant Proteins / Q000096:biosynthesis / Q000737:chemistry; D013050:Spectrometry, Fluorescence / Q000379:methods; D018411:Spodoptera; D014162:Transfection
chemical_list: D000318:Adrenergic beta-Agonists; D000319:Adrenergic beta-Antagonists; D005456:Fluorescent Dyes; D008024:Ligands; D010069:Oxadiazoles; D011412:Propanolamines; D018343:Receptors, Adrenergic, beta-2; D011994:Recombinant Proteins; C026777:ICI 118551; C035573:4-(N-(iodoacetoxy)ethyl-N-methyl)amino-7-nitrobenz-2-oxa-1,3-diazole; D011433:Propranolol; D000262:Adenylyl Cyclases; D003545:Cysteine; D007545:Isoproterenol; D004837:Epinephrine