Functional characteristics of heterologously expressed 5-HT receptors.
Over the past 10 years, molecular cloning has revealed the presence of 15 serotonin (5-hydroxytryptamine; 5-HT) receptor subtypes, which can be subdivided in seven subfamilies. Except for the 5-HT3 receptors, which are ligand-gated ion channels, all 5-HT receptors belong to the superfamily of G-protein-coupled receptors. The large multiplicity of 5-HT receptor subtypes has been suggested to be a direct result of the evolutionary age of the 5-HT system. Molecular information on G-protein-coupled 5-HT receptors is currently available for several mammalian species as well as for a limited number of invertebrate species (insects, molluscs). The aim of this review is to give an overview of all cloned 5-HT receptor subtypes belonging to the superfamily of G-protein-coupled receptors with specific emphasis on the pharmacological and signaling properties of the receptors upon expression in several heterologous expression systems.
Gerhardt
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Department of Biochemistry and Molecular Biology, Research Institute Neurosciences, Vrije Universteit, Amsterdam, The Netherlands.
van Heerikhuizen
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D000818:Animals; D001048:Aplysia / Q000737:chemistry; D004330:Drosophila / Q000737:chemistry; D005786:Gene Expression Regulation; D006801:Humans; D008195:Lymnaea / Q000737:chemistry; D044302:Receptor, Serotonin, 5-HT1B; D044346:Receptor, Serotonin, 5-HT1D; D044402:Receptor, Serotonin, 5-HT2A; D044405:Receptor, Serotonin, 5-HT2C; D011985:Receptors, Serotonin / Q000145:classification* / Q000235:genetics / Q000502:physiology*; D044263:Receptors, Serotonin, 5-HT1; D044422:Receptors, Serotonin, 5-HT4; D015398:Signal Transduction / Q000502:physiology*; D009626:Terminology as Topic; D000096642:Receptor, Serotonin, 5-HT1F
D044302:Receptor, Serotonin, 5-HT1B; D044346:Receptor, Serotonin, 5-HT1D; D044402:Receptor, Serotonin, 5-HT2A; D044405:Receptor, Serotonin, 5-HT2C; D011985:Receptors, Serotonin; D044263:Receptors, Serotonin, 5-HT1; D044422:Receptors, Serotonin, 5-HT4; D000096642:Receptor, Serotonin, 5-HT1F; C470302:HTR1B protein, human; C076396:serotonin 1E receptor; C097216:serotonin 6 receptor; C104425:serotonin 7 receptor