Lack of anticholinergic activity by baicalin in the isolated trachea of guinea pig.
The anticholinergic effect of baicalin on the trachea from asthmatic guinea pig had been described elsewhere. Using 1 x 10(-5) M bethanechol to induce contraction in the isolated trachea from non-asthmatic guinea pig, baicalin below 1 x 10(-4) M was unable to attenuate the bethanechol-induced tracheal contraction; however, 1 x 10(-4) M baicalin was demonstrated to increase the tracheal contraction in the presence of bethanechol. Baicalin (1 x 10(-4) M) was also able to induce tracheal contraction in the absence of bethanechol, and this baicalin-induced tracheal contraction was shown to be atropine-sensitive. These data suggested that the baicalin effect on the isolated trachea from non-asthmatic guinea pig was not anticholinergic in nature.
Wong
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D000818:Animals; D001249:Asthma; D018723:Bethanechol / Q000494:pharmacology; D018680:Cholinergic Antagonists; D004365:Drugs, Chinese Herbal; D005419:Flavonoids / Q000494:pharmacology*; D006168:Guinea Pigs; D066298:In Vitro Techniques; D007537:Isometric Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects / Q000502:physiology*; D014132:Trachea / Q000187:drug effects / Q000502:physiology*
D018680:Cholinergic Antagonists; D004365:Drugs, Chinese Herbal; D005419:Flavonoids; D018723:Bethanechol; C038044:baicalin