Experimental models for evaluating enzyme induction potential of new drug candidates in animals and humans and a strategy for their use.
Experimental models that have application for evaluating enzyme induction potential have been described in order of increasing complexity. The main focus was on models that have had wide application thus far. However, many new models are currently being developed that may have future applications in evaluating enzyme induction potential. A strategy to evaluate the enzyme induction potential of drug candidates was outlined. This scheme uses a combination of new and established techniques to evaluate data in a stepwise manner that is appropriate to the drug's current stage of development.
Thompson
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TN
Department of Drug Metabolism, North American Pharmacokinetics, Hoechst Marion Roussel, Inc., Kansas City, Missouri 64137, USA.
D000818:Animals; D015153:Blotting, Western; D002478:Cells, Cultured; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis*; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D004347:Drug Interactions; D004790:Enzyme Induction; D006801:Humans; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D010600:Pharmacology
D003577:Cytochrome P-450 Enzyme System