High intratumoural level of cytokines mediates efficient regression of a rat histiocytoma.
We have studied the role of cytokines in the spontaneous regression of AK-5 histiocytoma in syngeneic rats. Animals in which the tumour regresses show high levels of cytokines in the serum compared with animals which succumb to the tumour, and levels of IL-2, IL-4, IL-12, interferon-gamma (IFN-gamma) and tumour necrosis factor-alpha (TNF-alpha) are significantly higher in tumour tissue of the former. Thus there is an association between rejection of the tumour and the levels of cytokines present in the tumour mass. Our results also suggest a predominant Th1-type of response in those rats that display early tumour rejection.
Khar
A
A
Centre for Cellular & Molecular Biology, Hyderabad, India.
Muralikrishna
K
K
Varalakshmi
C
C
D000818:Animals; D016207:Cytokines / Q000097:blood / Q000276:immunology*; D018219:Histiocytoma, Benign Fibrous / Q000097:blood / Q000276:immunology* / Q000473:pathology*; D009365:Neoplasm Regression, Spontaneous / Q000276:immunology*; D009374:Neoplasms, Experimental / Q000097:blood / Q000276:immunology / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar; D012878:Skin Neoplasms / Q000097:blood / Q000276:immunology* / Q000473:pathology*
D016207:Cytokines