title: The basal ganglia and cognitive pattern generators.
abstract: This article introduces the notion of cognitive pattern generators and suggests, by analogy with the central pattern generators of the motor system, that these pattern generators operate to organize neural activity underlying aspects of action-oriented cognition. It is further proposed that the basal ganglia are involved in the control of cognitive as well as motor pattern generators. Disorders of the basal ganglia may thereby contribute to neural circuit dysfunctions that are expressed as positive and negative symptoms of schizophrenia.
authors.affiliation: Dept. of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge 02139, USA.
authors.forename: A M
authors.initials: AM
authors.lastname: Graybiel
mesh_terms: D001288:Attention / Q000502:physiology; D001479:Basal Ganglia / Q000503:physiopathology; D001480:Basal Ganglia Diseases / Q000175:diagnosis / Q000503:physiopathology* / Q000523:psychology; D001931:Brain Mapping; D003072:Cognition Disorders / Q000175:diagnosis / Q000503:physiopathology* / Q000523:psychology; D004298:Dopamine / Q000502:physiology; D006801:Humans; D009042:Motivation; D009415:Nerve Net / Q000503:physiopathology; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000175:diagnosis / Q000503:physiopathology*; D012565:Schizophrenic Psychology
chemical_list: D004298:Dopamine