Recurrence of nonalcoholic steatohepatitis in a liver transplant recipient.
A 42-year-old white man with morbid obesity and hypertriglyceridemia was noted to have nonalcoholic steatohepatitis (NASH) at the time of a laparoscopic cholecystectomy for presumed gallstone pancreatitis. His postoperative course was complicated by a 50-kg weight loss and continued right upper quadrant pain. Repeat liver biopsy revealed NASH with accompanying micronodular cirrhosis. Due to progressive fatigue, he underwent an orthotopic liver transplantation complicated by a 36-kg weight gain. Sixteen months posttransplantation, a liver biopsy revealed the recurrence of NASH. Screening for defects in fatty acid oxidation proved negative.
Carson
K
K
Department of Medicine, Duke University Medical Center, Durham, NC, USA.
Washington
M K
MK
Treem
W R
WR
Clavien
P A
PA
Hunt
C M
CM
D000328:Adult; D001706:Biopsy; D005234:Fatty Liver / Q000150:complications / Q000473:pathology*; D006505:Hepatitis / Q000150:complications / Q000473:pathology*; D006801:Humans; D015228:Hypertriglyceridemia / Q000150:complications; D016031:Liver Transplantation / Q000473:pathology*; D008297:Male; D009765:Obesity / Q000150:complications; D012008:Recurrence