title: Renal vascular transit time and tubular transit time dispersion for 99Tcm-MAG3.
abstract: Renal transit time usually refers to tubular transit time, as introduced by Taplin, but other measures of renal transit have been proposed. Here we examine the vascular transit time (VTT, following Rutland) and the standard deviation of tubular transit time (SDTT, following Britton) in a group of 30 patients having baseline and ACE-inhibitor 99Tcm-MAG3 renography prior to arteriography. A same-day, low-dose/high-dose protocol was used for renography; only the post-captopril dose was high enough to measure VTT. Pre-captopril, the Spearman rank correlation coefficient for SDTT was rho = 0.52 (n = 53 kidneys; P < 0.0002); post-captopril, rho = 0.54 (n = 49 kidneys; P < 0.0002). For VTT, the post-captopril value was rho = 0.24 (n = 30 kidneys; N.S.). For comparison, the same statistics were calculated for Taplin's original measure of transit time: the time from injection to maximum count rate (peak time). Pre-captopril, for peak time, rho was 0.47 (n = 53 kidneys; P < 0.001); post-captopril, rho was 0.39 (n = 50 kidneys, P < 0.01). These findings confirm the diagnostic value of SDTT but not of VTT. SDTT correlated better than peak time with the arteriographic findings.
authors.affiliation: University of Alabama Hospital, Birmingham, USA.
authors.forename: C D
authors.initials: CD
authors.lastname: Russell
authors.forename: M
authors.initials: M
authors.lastname: Japanwalla
authors.forename: S
authors.initials: S
authors.lastname: Khan
authors.forename: J W
authors.initials: JW
authors.lastname: Scott
authors.forename: E V
authors.initials: EV
authors.lastname: Dubovsky
mesh_terms: D000328:Adult; D000806:Angiotensin-Converting Enzyme Inhibitors; D002216:Captopril; D006801:Humans; D007668:Kidney / Q000000981:diagnostic imaging*; D007684:Kidney Tubules / Q000000981:diagnostic imaging / Q000378:metabolism; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D012078:Renal Artery Obstruction / Q000000981:diagnostic imaging; D012079:Renal Circulation; D017263:Technetium Tc 99m Mertiatide / Q000493:pharmacokinetics
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D019275:Radiopharmaceuticals; D017263:Technetium Tc 99m Mertiatide; D002216:Captopril