title: Effect of high fiber intake in fish oil-treated patients with non-insulin-dependent diabetes mellitus.
abstract: The short-term effect of high fiber intake on fish-oil treatment in 15 free-living, non-insulin-dependent diabetic patients was evaluated by using a controlled, sequential study design. During an 8-wk fish-oil-treatment period when patients received 20 g fish oil/d, the usual daily fiber intake was increased with a 15-g pectin supplement at midpoint. Fish oil alone lowered triacylglycerol and very-low-density-lipoprotein-cholesterol concentrations by 41% and 36%, respectively (both P < 0.01 by the end of the treatment period) with unchanged mean total, low-density-, and high-density-lipoprotein-cholesterol concentrations. When the fiber intake was increased, however, total and low-density-lipoprotein-cholesterol concentrations decreased significantly (P < 0.001 and < 0.05, respectively) with fish-oil treatment. The cholesterol ester fraction of plasma lipids was reduced by 34% when compared with fish oil alone (P < 0.05). The plasma triacylglycerol fraction decreased further by 44% (P < 0.001). Other beneficial effects observed included a 30% decline in the fatty acid fraction (P < 0.002) by end of the treatment period. Diabetic control was maintained during the 12-wk study. In conclusion, a high fiber intake may be beneficial in fish oil-treated diabetic patients.
authors.affiliation: Department of Medicine, Case Western Reserve University, School of Medicine, Cleveland, USA.
authors.forename: J P
authors.initials: JP
authors.lastname: Sheehan
authors.forename: I W
authors.initials: IW
authors.lastname: Wei
authors.forename: M
authors.initials: M
authors.lastname: Ulchaker
authors.forename: K Y
authors.initials: KY
authors.lastname: Tserng
mesh_terms: D000328:Adult; D000368:Aged; D001786:Blood Glucose; D003300:Copper / Q000097:blood / Q000652:urine; D003924:Diabetes Mellitus, Type 2 / Q000178:diet therapy* / Q000378:metabolism; D004043:Dietary Fiber / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D005395:Fish Oils / Q000627:therapeutic use*; D006801:Humans; D008274:Magnesium / Q000097:blood / Q000652:urine; D008297:Male; D008875:Middle Aged; D010368:Pectins / Q000008:administration & dosage / Q000627:therapeutic use*; D015032:Zinc / Q000097:blood / Q000652:urine
chemical_list: D001786:Blood Glucose; D004043:Dietary Fiber; D005395:Fish Oils; D003300:Copper; D010368:Pectins; D008274:Magnesium; D015032:Zinc