Synthesis of Tn and sialyl Tn antigen-lipid A analog conjugates for synthetic vaccines.
Conjugates of Tn and sialyl Tn antigen with N-teradecanoyl L-seryl-beta-alanine-containing D-glucosamine derivatives structurally related to lipid A as an immunoadjuvant were synthesized for the development of totally synthetic vaccines against cancers or HIV.
Miyajima
K
K
School of Pharmaceutical Sciences, University of Shizuoka, Japan.
Nekado
T
T
Ikeda
K
K
Achiwa
K
K
D015295:Antigens, Tumor-Associated, Carbohydrate / Q000737:chemistry*; D002236:Carbohydrate Conformation; D002240:Carbohydrate Sequence; D008050:Lipid A / Q000737:chemistry*; D008969:Molecular Sequence Data; D014614:Vaccines, Synthetic / Q000737:chemistry*
D015295:Antigens, Tumor-Associated, Carbohydrate; D008050:Lipid A; D014614:Vaccines, Synthetic; C055491:sialosyl-Tn antigen