title: Splenomegaly as the first manifestation of thyroid cancer metastases.
abstract: We report the case of a 65-year-old man who developed a symptomatic splenomegaly due to spleen metastasis from thyroid follicular carcinoma. In 1982, at the age of 53, the patient had undergone a thyroid lobectomy for a cold node, followed one year later by a second intervention for a microfollicular adenoma. He was subsequently administered thyroid suppressive therapy with no further follow-up. The diagnosis of spleen metastases from thyroid cancer was first suspected on the basis of history, high serum thyroglobulin (Tg) levels, and the presence of pulmonary 99Tc uptake. The patient underwent a splenectomy, during which vast infiltration involving the diaphragm, spleen, stomach, colon and pancreas, was found. Histological and immunohistochemical results showed that the spleen and diaphragm metastases derived from thyroid follicular carcinoma. Radioiodine uptake by the pulmonary metastases confirmed the thyroid source. Retrospective re-evaluation of the thyroid tissue removed in 1983 revealed a histological pattern consistent with follicular carcinoma, which could not be unequivocally attributed to the widely or minimally invasive form. To our knowledge this is the first report of splenomegaly as the first manifestation of thyroid cancer metastases. In this paper cases of splenomegaly due to metastatic spread are reviewed and the management of the present case is discussed.
authors.affiliation: IVth Chair of Internal Medicine, University of Padua Medical School, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Paolini
authors.forename: S
authors.initials: S
authors.lastname: Toffoli
authors.forename: A
authors.initials: A
authors.lastname: Poletti
authors.forename: D
authors.initials: D
authors.lastname: Casara
authors.forename: P
authors.initials: P
authors.lastname: Moschino
authors.forename: F
authors.initials: F
authors.lastname: Fabris
authors.forename: A
authors.initials: A
authors.lastname: Girolami
mesh_terms: D018263:Adenocarcinoma, Follicular / Q000175:diagnosis* / Q000473:pathology / Q000556:secondary*; D000368:Aged; D003937:Diagnosis, Differential; D006801:Humans; D008297:Male; D013160:Splenic Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000556:secondary*; D013163:Splenomegaly / Q000209:etiology* / Q000473:pathology; D013964:Thyroid Neoplasms / Q000473:pathology*