title: Hepatitis C virus nonstructural region 5A protein is a potent transcriptional activator.
abstract: The hepatitis C virus (HCV) nonstructural region 5A (NS5A) protein, without its 146 amino-terminal amino acids and fused to the DNA-binding domain of GAL4, strongly activates transcription in yeast and human hepatoma cells. Transcriptional activation by the HCV NS5A protein may play a role in viral replication and hepatocarcinogenesis.
authors.affiliation: Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan. kato-2im@h.u-tokyo.ac.jp
authors.forename: N
authors.initials: N
authors.lastname: Kato
authors.forename: K H
authors.initials: KH
authors.lastname: Lan
authors.forename: S K
authors.initials: SK
authors.lastname: Ono-Nita
authors.forename: Y
authors.initials: Y
authors.lastname: Shiratori
authors.forename: M
authors.initials: M
authors.lastname: Omata
mesh_terms: D000595:Amino Acid Sequence; D005260:Female; D015967:Gene Expression Regulation, Viral; D006526:Hepatitis C / Q000235:genetics* / Q000821:virology; D006801:Humans; D007477:Ions; D008297:Male; D008969:Molecular Sequence Data; D015534:Trans-Activators / Q000235:genetics*; D014157:Transcription Factors / Q000235:genetics*; D014158:Transcription, Genetic; D015533:Transcriptional Activation; D017361:Viral Nonstructural Proteins / Q000235:genetics*; D012324:RNA-Dependent RNA Polymerase
chemical_list: D007477:Ions; D015534:Trans-Activators; D014157:Transcription Factors; D017361:Viral Nonstructural Proteins; C087036:NS-5 protein, hepatitis C virus; D012324:RNA-Dependent RNA Polymerase