Evaluation for malignant hyperthermia susceptibility in black-tailed deer.
To investigate a possible link of malignant hyperthermia to capture myopathy, between June 1990 and July 1993 we anesthetized four black-tailed deer (Odocoileus hemionus columbianus) and challenged them with halothane and succinylcholine. Halothane had no significant effect on oxygen consumption. Succinylcholine significantly (P < 0.05) increased cardiac output (mean +/- SD), from 2.94 +/- 1.05 l/min to 5.26 +/- 1.79 l/min, and oxygen consumption, from 5.5 +/- 2.1 ml/kg/min to 10.1 +/- 2.9 ml/kg/min. Muscle biopsy specimens tested for malignant hyperthermia susceptibility responded normally to halothane and caffeine. We conclude that these deer did not experience malignant hyperthermia; suggesting no link to capture myopathy.
Antognini
J F
JF
Department of Anesthesiology, University of California, Davis 95616, USA.
Eisele
P H
PH
Gronert
G A
GA
D018685:Anesthetics, Inhalation; D000818:Animals; D001784:Blood Gas Analysis / Q000662:veterinary; D002302:Cardiac Output / Q000187:drug effects; D003670:Deer; D004198:Disease Susceptibility; D004305:Dose-Response Relationship, Drug; D005260:Female; D006221:Halothane; D008297:Male; D008305:Malignant Hyperthermia / Q000503:physiopathology / Q000662:veterinary*; D018482:Muscle, Skeletal / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology; D009467:Neuromuscular Depolarizing Agents / Q000009:adverse effects*; D010101:Oxygen Consumption / Q000187:drug effects; D013390:Succinylcholine / Q000009:adverse effects*
D018685:Anesthetics, Inhalation; D009467:Neuromuscular Depolarizing Agents; D013390:Succinylcholine; D006221:Halothane