Reduction of malachite green to leucomalachite green by intestinal bacteria.
Intestinal microfloras from human, rat, mouse, and monkey fecal samples and 14 pure cultures of anaerobic bacteria representative of those found in the human gastrointestinal tract metabolized the triphenylmethane dye malachite green to leucomalachite green. The reduction of malachite green to the leuco derivative suggests that intestinal microflora could play an important role in the metabolic activation of the triphenylmethane dye to a potential carcinogen.
Henderson
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AL
National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas 72079, USA.
Schmitt
T C
TC
Heinze
T M
TM
Cerniglia
C E
CE
D000814:Aniline Compounds / Q000378:metabolism* / Q000633:toxicity; D000818:Animals; D001419:Bacteria / Q000302:isolation & purification / Q000378:metabolism*; D001421:Bacteria, Anaerobic / Q000378:metabolism; D002273:Carcinogens / Q000378:metabolism / Q000633:toxicity; D002851:Chromatography, High Pressure Liquid; D005243:Feces / Q000382:microbiology; D006801:Humans; D007422:Intestines / Q000382:microbiology*; D008253:Macaca mulatta; D013058:Mass Spectrometry; D051379:Mice; D008809:Mice, Inbred C3H; D010084:Oxidation-Reduction; D051381:Rats; D011916:Rats, Inbred F344; D012394:Rosaniline Dyes / Q000378:metabolism* / Q000633:toxicity
D000814:Aniline Compounds; D002273:Carcinogens; D012394:Rosaniline Dyes; C005095:malachite green; C015320:leucomalachite green