title: Autoregulation of human optic nerve head blood flow in response to acute changes in ocular perfusion pressure.
abstract: BACKGROUND
  Studies in animals have demonstrated that optic nerve head (ONH) blood flow (F(onh)) is autoregulated, but there is a lack of evidence for such a process in humans. Therefore, we investigated the relationship between F(onh) and mean ocular perfusion pressure (PPm) in normal volunteers when PPm is decreased through elevation of the intraocular pressure (IOP).
  
  
  METHODS
  Laser Doppler flowmetry (LDF) was used to measure relative mean velocity (Velohn), volume (Volonh) and F(onh) of blood at sites of the ONH away from visible vessels, while PPm was decreased in two ways: (1) rapidly, by IOP increments of 15 s duration, and (2) slowly, by IOP increments of 2 min duration, both by scleral suction cup in one eye of each of nine subjects.
  
  
  RESULTS
  A rapid and large decrease of PPm of more than 100% induced a decrease of more than 80% in F(onh). With the slower decrease in PPm, F(onh) remained constant down to a PPm of approximately 22 mm Hg (IOP = 40 mm Hg) and then decreased, predominantly due to a decrease in Velohn. Immediately after removal of the suction cup, F(onh) increased transiently by 44% above baseline.
  
  
  CONCLUSIONS
  This study demonstrates efficient blood flow autoregulation in the OHN, which is probably brought about by an increase in vascular capacitance. The magnitude of the reactive hyperaemia agrees with the compensatory decrease in ONH vascular resistance during IOP elevation. The time scale of the autoregulatory process and the dependence of the hyperaemia upon duration of IOP elevation suggest a metabolic mechanism of autoregulation.
authors.affiliation: Institut de Recherche en Ophthalmologie, Sion, Switzerland. charles.riva@iro.vsnet.ch
authors.forename: C E
authors.initials: CE
authors.lastname: Riva
authors.forename: M
authors.initials: M
authors.lastname: Hero
authors.forename: P
authors.initials: P
authors.lastname: Titze
authors.forename: B
authors.initials: B
authors.lastname: Petrig
mesh_terms: D000328:Adult; D001783:Blood Flow Velocity; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology; D017078:Laser-Doppler Flowmetry; D008297:Male; D008875:Middle Aged; D009798:Ocular Hypertension / Q000503:physiopathology*; D009898:Optic Disk / Q000098:blood supply*; D010477:Perfusion; D011312:Pressure