Influence of rigid gas permeable contact lens solutions on corneal epithelial wound healing.
To determine the effect of RGP contact lens solution on corneal epithelial wound healing, the following solutions including Soaclens, Contopharma GPHCL-S, Boston condition, Bausch & Lomb condition and Duracare were applied on corneal epithelial wounds of enucleated pig eyes to evaluate possible cytotoxicity of RGP solutions. The wounds, created by excimer laser, were 1.5mm in diameter with 70 microns in depth. The eyeballs were maintained in an incubator using a perfusion system. After twenty-four hours, a score from 3 to 0 was given depending on the size of defect from absence of healing to completely healing. The average scores of the epithelial defect in each group are: Soaclens: 0.38 +/- 0.74; GPHCL-S: 0.63 +/- 0.52; Boston condition: 0.38 +/- 0.52; Bausch & Lomb condition: 0.25 +/- 0.46 and Duracare: 2.38 +/- 0.52. Most of the epithelial wounds healed with one exception, the eyeballs which received Duracare still had large defects. The difference of scores between Duracare and other groups are statistically significant. Duracare, which contains benzalkonium chloride, may be responsible for retarded wound healing.
Lin
C P
CP
Department of Ophthalmology, Kaohsiung Medical College, Taiwan, Republic of China.
Boehnke
M
M
D000818:Animals; D018639:Contact Lens Solutions / Q000009:adverse effects*; D003315:Cornea / Q000187:drug effects*; D004848:Epithelium / Q000187:drug effects; D013552:Swine; D014945:Wound Healing / Q000187:drug effects*
D018639:Contact Lens Solutions