title: Modeling mechanical cardiopulmonary interactions for virtual environments.
abstract: We have developed a computer system for modeling mechanical cardiopulmonary behavior in an interactive, 3D virtual environment. The system consists of a compact, scalar description of cardiopulmonary mechanics, with an emphasis on respiratory mechanics, that drives deformable 3D anatomy to simulate mechanical behaviors of and interactions between physiological systems. Such an environment can be used to facilitate exploration of cardiopulmonary physiology, particularly in situations that are difficult to reproduce clinically. We integrate 3D deformable body dynamics with new, formal models of (scalar) cardiorespiratory physiology, associating the scalar physiological variables and parameters with corresponding 3D anatomy. Our approach is amenable to modeling patient-specific circumstances in two ways. First, using CT scan data, we apply semi-automatic methods for extracting and reconstructing the anatomy to use in our simulations. Second, our scalar models are defined in terms of clinically-measurable, patient-specific parameters. This paper describes our approach and presents a sample of results showing normal breathing and acute effects of pneumothoraces.
authors.affiliation: Center for Human Modeling and Simulation, University of Pennsylvania/VAMC, Philadelphia, USA.
authors.forename: J M
authors.initials: JM
authors.lastname: Kaye
mesh_terms: D003198:Computer Simulation; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008953:Models, Anatomic; D008954:Models, Biological; D008955:Models, Cardiovascular; D011030:Pneumothorax / Q000473:pathology / Q000503:physiopathology; D015656:Respiratory Mechanics; D012137:Respiratory System / Q000033:anatomy & histology; D013898:Thoracic Injuries / Q000473:pathology / Q000503:physiopathology; D014057:Tomography, X-Ray Computed; D014584:User-Computer Interface; D014684:Venae Cavae / Q000033:anatomy & histology / Q000502:physiology