[Rheumatoid arthritis as a risk factor for development of multiple myeloma].
7 out of 154 patients with multiple myeloma (MM) with concomitant rheumatoid arthritis (RA) (5 persons) and Bechterev disease (BD) (2 persons) have been presented. There were 5 women and 2 men at age from 52 to 67 years. Four of them had joint's disease for 4, 5, 24 and 25 years prior to MM, and in the next there MM was diagnosed simultaneously with RA. Two patients are still living (50 and 55 months from the diagnosis of MM), the mean survival time of the five already dead was 34.5 months, and did not differ from the survival of patients with MM alone. The contribution of interleukin-6 (Il-6) and adhesion molecules ICAM-1, VCAM-1, CD44 in pathogenesis of both diseases are discussed.
Usnarska-Zubkiewicz
L
L
Katedra i Klinika Hematologii i Chorób Rozrostowych Krwi, Akademia Medyczna we Wrocławiu.
Czarnecka
M
M
Włodarczyk
S
S
Nowak
E
E
D000368:Aged; D001172:Arthritis, Rheumatoid / Q000150:complications* / Q000503:physiopathology; D015815:Cell Adhesion Molecules / Q000502:physiology; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000502:physiology; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000209:etiology* / Q000401:mortality / Q000503:physiopathology; D013167:Spondylitis, Ankylosing / Q000150:complications / Q000503:physiopathology; D015996:Survival Rate
D015815:Cell Adhesion Molecules; D015850:Interleukin-6