title: Poisoning by sodium channel blocking agents.
abstract: Poisoning by drugs that block voltage-gated sodium channels produces intraventricular conduction defects, myocardial depression, bradycardia, and ventricular arrhythmias. Human and animal reports suggest that hypertonic sodium bicarbonate may be effective therapy for numerous agents possessing sodium channel blocking properties, including cocaine, quinidine, procainamide, flecainide, mexiletine, bupivacaine, and others.
authors.affiliation: Department of Medical Toxicology, Good Samaritan Regional Medical Center, Phoenix, Arizona, USA.
authors.forename: P F
authors.initials: PF
authors.lastname: Kolecki
authors.forename: S C
authors.initials: SC
authors.lastname: Curry
mesh_terms: D000200:Action Potentials; D064420:Drug-Related Side Effects and Adverse Reactions; D006321:Heart / Q000187:drug effects; D006331:Heart Diseases / Q000139:chemically induced* / Q000188:drug therapy; D006801:Humans; D011041:Poisoning / Q000150:complications; D017693:Sodium Bicarbonate / Q000627:therapeutic use; D026941:Sodium Channel Blockers; D015222:Sodium Channels / Q000502:physiology
chemical_list: D026941:Sodium Channel Blockers; D015222:Sodium Channels; D017693:Sodium Bicarbonate