Comparative mutagenic and genotoxic effects of three propionic acid derivatives ibuprofen, ketoprofen and naproxen.
The mutagenicity of three propionic acid derivatives, namely ibuprofen, ketoprofen and naproxen, was tested in the Ames mutagenicity assay (in strains TA97a, TA100 and TA102) and in vivo genotoxicity was tested by sister chromatid exchange (SCE) in bone marrow cells of mice. These are the anti-inflammatory drugs frequently used in different parts of the world. Mutagenicity results showed no mutagenic effects in strains TA97a, TA100 and TA102 for all three drugs. Results of in vivo SCE assays indicate that these three drugs are weakly genoxic in bone marrow cells of mice. This is the first report of the Ames mutagenicity assay for ketoprofen and in vivo SCE assay for three drugs.
Philipose
B
B
Indian Institute of Chemical Biology, Jadavpur, Calcutta, India.
Singh
R
R
Khan
K A
KA
Giri
A K
AK
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000633:toxicity*; D001854:Bone Marrow Cells / Q000187:drug effects; D007052:Ibuprofen / Q000633:toxicity*; D066298:In Vitro Techniques; D007660:Ketoprofen / Q000633:toxicity*; D008297:Male; D051379:Mice; D008862:Microsomes, Liver / Q000378:metabolism; D009152:Mutagenicity Tests; D009153:Mutagens / Q000633:toxicity*; D009288:Naproxen / Q000633:toxicity*; D051381:Rats; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics; D012854:Sister Chromatid Exchange / Q000187:drug effects
D000894:Anti-Inflammatory Agents, Non-Steroidal; D009153:Mutagens; D009288:Naproxen; D007660:Ketoprofen; D007052:Ibuprofen