Desensitisation of substance P decreases the contractile effect of M15 and Gal (1-14)-(Abu 8) SCY-I on the rat gastric fundus.
Tachyphylaxis to SP decreased the effect of M15 and Gal(1-14)-[Abu8]SCY-I on gastric smooth muscles, without effect on the action of Gal. These findings support our initial hypothesis: the action of M15 and Gal(1-14)-[Abu8]SCY-I on the smooth muscles may not only be due to their agonist activity at Gal receptors, but may result from a subsequent stimulation of receptors for SP and perhaps for other tachykinins as well, however, a possibility that Gal analogues release endogenous SP can not be excluded. Further studies involving a tachykinin antagonist (spantide) are in progress at the moment. [1].
Korolkiewicz
R
R
Department of Pharmacology, Medical University of Gdansk, Poland.
Sliwinski
W
W
Rekowski
P
P
Halama
A
A
Szczurowicz
A
A
Korolkiewicz
K Z
KZ
D000818:Animals; D019004:Galanin / Q000031:analogs & derivatives* / Q000494:pharmacology*; D005748:Gastric Fundus / Q000187:drug effects; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects*; D064729:Neurokinin-1 Receptor Antagonists; D051381:Rats; D017208:Rats, Wistar; D013373:Substance P / Q000031:analogs & derivatives* / Q000494:pharmacology; D015320:Tachykinins / Q000494:pharmacology*; D013618:Tachyphylaxis / Q000502:physiology
D064729:Neurokinin-1 Receptor Antagonists; D015320:Tachykinins; C109871:gal (1-14)-(Abu 8) scy-I; C074975:galantide; D013373:Substance P; D019004:Galanin