title: The heart and conduit vessels in hypertension.
abstract: The heart and conduit vessels, integral components of a pulsatile pumping system, undergo complex adaptive and degenerative changes in response to the increased load of hypertension. Over the last two decades, great technological strides have been made with regards to further discovering the role of the heart and conduit vessels in hypertension. This article reviews the adaptation of the heart and vessels to hypertension, the clinical implications of these structural and functional changes, and the effects of therapy on cardiovascular function.
authors.affiliation: Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: G F
authors.initials: GF
authors.lastname: Mitchell
authors.forename: J M
authors.initials: JM
authors.lastname: Pfeffer
authors.forename: M A
authors.initials: MA
authors.lastname: Pfeffer
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D002320:Cardiovascular Physiological Phenomena / Q000187:drug effects; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000503:physiopathology*; D017379:Hypertrophy, Left Ventricular / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology*; D008297:Male
chemical_list: D000959:Antihypertensive Agents