title: Conservative surgery in high-risk epithelial ovarian carcinoma.
abstract: BACKGROUND
  In epithelial ovarian cancer, conservative surgery has mainly been adopted for stage Ia disease. The aim of this study is to report on a conservative surgical approach used in selected young patients with ovarian cancer who would usually undergo radical operations.
  
  
  METHODS
  From 1980 through 1994, 10 patients with invasive epithelial ovarian cancer and with high-grade or limited extraovarian disease were treated with conservative surgery. The mean age was 22.7 years. The stage was Ia grade 3 in 2 patients, Ic in 2 patients, IIIa in 2 patients, and IIIc in 4 patients. Eight patients were given adjuvant therapy (radiotherapy in 1 and chemotherapy in 7).
  
  
  RESULTS
  All patients were alive and disease-free at a median followup time of 70 months (range 24-138 months). Nine patients were menstruating regularly and three had become pregnant.
  
  
  CONCLUSIONS
  It seems that in selected patients, conservative operations can be used beyond the worldwide accepted criterion of stage Ia. This concept deserves additional investigation in larger series.
authors.affiliation: Department of Gynecologic Surgical Oncology, Istituto Nazionale Tumori, Milan, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Raspagliesi
authors.forename: R
authors.initials: R
authors.lastname: Fontanelli
authors.forename: D
authors.initials: D
authors.lastname: Paladini
authors.forename: E M
authors.initials: EM
authors.lastname: di Re
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000473:pathology / Q000601:surgery*; D000293:Adolescent; D000328:Adult; D018284:Cystadenocarcinoma, Serous / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D008197:Lymph Node Excision; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000473:pathology / Q000601:surgery*; D016896:Treatment Outcome