Developmental expression of synaptophysin, synapsin I and syntaxin in the rat retina.
Expression of synaptophysin, synapsin I and syntaxin was studied immunocytochemically in the developing rat retina using indirect immunoperoxidase technique. In the inner plexiform layer (IPL), syntaxin immunoreactivity appeared at postnatal day 1 (P1) whereas synaptophysin and synapsin I staining were first observed at P2. In the outer plexiform layer (OPL), synaptophysin appeared at P4, while synapsin I and syntaxin appeared at P8. In the case of synaptophysin, a punctate pattern of staining was observed from the time of its appearance (P4) in the OPL and from P12 onwards in the IPL. Synapsin I and syntaxin immunoreactivity in the OPL were of a low intensity throughout the development and in the adult stage. These findings are discussed in relation to synaptogenesis in the rat retina.
Dhingra
N K
NK
Department of Neurophysiology, National Institute of Mental Health and Neuro Sciences, Bangalore, India.
Ramamohan
Y
Y
Raju
T R
TR
D000818:Animals; D005260:Female; D007124:Immunoenzyme Techniques; D008297:Male; D008565:Membrane Proteins / Q000096:biosynthesis; D009419:Nerve Tissue Proteins / Q000096:biosynthesis*; D050765:Qa-SNARE Proteins; D051381:Rats; D017208:Rats, Wistar; D012160:Retina / Q000254:growth & development* / Q000378:metabolism; D016704:Synapsins / Q000096:biosynthesis; D016708:Synaptophysin / Q000096:biosynthesis
D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; D050765:Qa-SNARE Proteins; D016704:Synapsins; D016708:Synaptophysin