title: [Tolosa-Hunt syndrome. Troubles in diagnosis and pattern of response to prednisone].
abstract: The Tolosa-Hunt syndrome (THS) consists of a painful ophthalmoplegia related to granulomatous inflammatory process in the cavernous sinus. According to recent concepts, the diagnosis is established only when other causes of painful ophthalmoplegia are ruled out. A typical pattern of response to corticosteroids associated with a benign evolution may reinforce this possibility. Tumors such as lymphoma and meningioma and orbital pseudotumors can make difficult the differential diagnosis because they also may respond to steroids. Thus it is always necessary to make an extensive ancillary investigation. We performed a clinical, laboratory and radiologic study of five patients with THS. Prednisone was used in all, with dosages ranging from 40 to 80 mg/day. In four patients there was a dramatic analgesic effect in less than 48 hours. Improvement of the ophthalmoplegia was not so fast but occurred in all with a complete remission in 4 to 45 days.
authors.affiliation: Departamento de Neurologia da Faculdade de Medicina da Universidade de São Paulo (FMUSP), Brasil.
authors.forename: P E
authors.initials: PE
authors.lastname: Carrilho
authors.forename: F I
authors.initials: FI
authors.lastname: Yamamoto
authors.forename: M
authors.initials: M
authors.lastname: Scaff
mesh_terms: D000328:Adult; D000368:Aged; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009886:Ophthalmoplegia / Q000175:diagnosis* / Q000188:drug therapy*; D011241:Prednisone / Q000627:therapeutic use*
chemical_list: D000893:Anti-Inflammatory Agents; D011241:Prednisone