1-Octadecene as a solvent for ferrofluids for intraocular use.
OBJECTIVE
1-Octadecene is a hydrocarbon with one double bond in its structure that could serve as a solvent for ferrofluids. The aim of this pilot study was to obtain preliminary information on intraocular tolerance to 1-octadecene.


METHODS
Vitreous compression with perfluoropropane gas was achieved in 20 eyes of albino rabbits. Four days after gas injection a fluid-gas exchange was undertaken. Sixteen eyes received 1-octadecene. Four eyes received balanced salt solution. Eyes were obtained at 3, 7, 14 and 30 days. The samples were fixed in 10% buffered formalin, processed in paraffin and sections were stained with hematoxylin and eosin.


RESULTS
Emulsification of the oil bubble was observed in 31.25% of the cases by the fifth day; light microscopy showed normal retinal architecture in all the eyes and epiretinal and vitreous macrophages in 50% of the eyes.


CONCLUSIONS
1-Octadecene does not appear to have any retinal cytotoxic effect but elicits an inflammatory response in the vitreous activity.
Tejada
P
P
Hospital 12 de Octubre, Madrid, Spain.
Méndez
M J
MJ
Madero
S
S
Cava
C
C
Barcelo
A
A
Castellano
V
V
D000475:Alkenes / Q000633:toxicity*; D000818:Animals; D004655:Emulsions; D005466:Fluorocarbons / Q000008:administration & dosage; D015745:Granuloma, Foreign-Body / Q000139:chemically induced / Q000473:pathology; D008264:Macrophages / Q000473:pathology; D009504:Neutrophils / Q000473:pathology; D010865:Pilot Projects; D011817:Rabbits; D012160:Retina / Q000187:drug effects* / Q000473:pathology; D012590:Sclera / Q000473:pathology; D012997:Solvents / Q000633:toxicity*; D014821:Vitrectomy / Q000379:methods; D014822:Vitreous Body / Q000473:pathology
D000475:Alkenes; D004655:Emulsions; D005466:Fluorocarbons; D012997:Solvents; C042852:perflutren; C109760:1-octadecene