Paracetamol induced acute interstitial nephritis superimposed on mesangiocapillary glomerulonephritis.
We report the case of a young alcoholic male whose first renal biopsy disclosed mesangiocapillary glomerulonephritis. One month later he took 1.5 g paracetamol to control the fever. Soon he got hospitalized due to toxicoderma, elevated liver and renal function tests. While the liver enzymes returned to normal, uremia developed. A repeated renal biopsy revealed severe interstitial inflammation, tubular atrophy. Haemodialysis was started and he got steroids (1 mg/kg body weight). He showed considerable recovery of renal function in some weeks. The case points to the possibility that paracetamol-even in therapeutic dosage-might result in hepatic and renal damage in alcoholics.
Trinn
C
C
Second Deptartment of Medicine, University Medical School Pécs, Hungary.
Szöke
B
B
Tóth
T
T
Nagy
J
J
D000082:Acetaminophen / Q000633:toxicity*; D000328:Adult; D000437:Alcoholism / Q000150:complications; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000633:toxicity*; D015432:Glomerulonephritis, Membranoproliferative / Q000139:chemically induced* / Q000150:complications / Q000473:pathology; D006801:Humans; D007668:Kidney / Q000473:pathology; D008099:Liver / Q000473:pathology; D008297:Male; D009395:Nephritis, Interstitial / Q000139:chemically induced* / Q000150:complications / Q000473:pathology
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000082:Acetaminophen