title: Bioactive constituents of Morus australis and Broussonetia papyrifera.
abstract: The biological activities of the active principles of two plants in the Moraceae have been investigated. A new prenylflavonoid, australone A (1), and a new triterpenoid, 3 beta-[(m-methoxybenzoyl)oxy]urs-12-en-28-ioc acid (2) were isolated from the root bark of Morus australis, and their structures determined by spectroscopic methods. Also isolated from this plant were seven known compounds, morusin (3), kuwanon C (4), betulinic acid, beta-amyrin, quercetin, ursolic acid, and compound A. Morusin (3) showed significant effects on arachidonic acid-, collagen-, and PAF-induced platelet aggregation, while kuwanon C (4) was active in the arachidonic acid- and PAF-induced platelet aggregation assays. In biological work on a second plant, Broussonetia papyrifera, broussoflavonols F (5) and G (6), broussoflavan A (7), and broussoaurone A (8) potently inhibited Fe(2+)-induced lipid oxidation in rat-brain homogenate. Compounds 5-7 also significantly inhibited the proliferation of rat vascular smooth muscle cells.
authors.affiliation: School of Pharmacy, Kaohsiung Medical College, Taiwan, Republic of China.
authors.forename: H H
authors.initials: HH
authors.lastname: Ko
authors.forename: S M
authors.initials: SM
authors.lastname: Yu
authors.forename: F N
authors.initials: FN
authors.lastname: Ko
authors.forename: C M
authors.initials: CM
authors.lastname: Teng
authors.forename: C N
authors.initials: CN
authors.lastname: Lin
mesh_terms: D000818:Animals; D001013:Aorta, Thoracic / Q000166:cytology / Q000187:drug effects; D001923:Brain Chemistry / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D005419:Flavonoids / Q000302:isolation & purification* / Q000494:pharmacology; D066298:In Vitro Techniques; D015227:Lipid Peroxidation / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D009131:Muscle, Smooth, Vascular / Q000166:cytology / Q000187:drug effects; D010946:Plants, Medicinal / Q000737:chemistry*; D010974:Platelet Aggregation / Q000187:drug effects; D011817:Rabbits; D051381:Rats; D013056:Spectrophotometry, Ultraviolet; D013936:Thymidine / Q000378:metabolism; D014315:Triterpenes / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: C109391:3-((methoxybenzoyl)oxy)urs-12-en-28-oic acid; D005419:Flavonoids; D014315:Triterpenes; C109390:australone A; D013936:Thymidine