The effect of marker heterozygosity on the power to detect linkage disequilibrium.
The relationship between marker heterozygosity and the power to detect linkage disequilibrium is examined through the analysis of an example and through a simulation study. The analysis suggests that, despite the penalties for multiple testing incurred with multiple alleles, greater heterozygosity results in greater power. The results of the simulation study are in accord with those of the analysis.
Ott
J
J
Laboratory of Statistical Genetics, Rockefeller University, New York, New York 10021, USA.
Rabinowitz
D
D
D005819:Genetic Markers; D006579:Heterozygote; D015810:Linkage Disequilibrium; D008957:Models, Genetic
D005819:Genetic Markers