title: [Dermo-pharmaceutical efficacy of emulsions with NEO-PCL: galenic and rheological studies].
abstract: The future EU prohibition (Directive 86/609/CEE) of using experimentation animals has induced the implementation of non-invasive techniques which are to substitute the present methods. Two non-invasive techniques are used to determine the cosmetological effectiveness of two emulsions formulated on a modern excipient NEO-PCL Base. Furthermore, the incorporation of multiflower honey is analyzed, being carried out the appropriate essays in order to obtain its tipification from a galenic and rheological point of view. After the formulation adjustment, O/W emulsioned systems, eudermic pH, and the rheological parameters to its application on the skin are obtained. Out of the effectiveness study, a high moisturization/emolliency degree is deduced. On the other hand, we conclude that multiflower honey rises the moisturizing power on this kind of products.
authors.affiliation: Departamento de Farmacia y Tecnología Farmacéutica, Facultad de Farmacia, Universidad de Alcalá de Henares, Madrid.
authors.forename: M J
authors.initials: MJ
authors.lastname: Fresno Contreras
authors.forename: M M
authors.initials: MM
authors.lastname: Jiménez Soriano
authors.forename: E
authors.initials: E
authors.lastname: Sellés Flores
mesh_terms: D003358:Cosmetics / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D004655:Emulsions; D006722:Honey; D066298:In Vitro Techniques; D012212:Rheology; D012867:Skin / Q000187:drug effects*
chemical_list: D003358:Cosmetics; D004655:Emulsions