title: Unusual lactam formation occurring in the synthesis of a biotinylated T-antigen-serine derivative.
abstract: Synthesis of the biotinylated T-antigens, linked to a serine by an alpha (7 alpha) or a beta (7 beta) 2-acetamido-2-deoxy-D-galactoside bond, is described. These derivatives were needed for the detection of a specific endogenous lectin at the surface and/or on the migration pathway of melanoma cells. In the course of the synthesis, an unusual lactam formation was observed with the beta anomer of the azido-disaccharide 5 beta.
authors.affiliation: Institut Pasteur, Département de Biochimie et Génétique Moléculaire, Paris, France.
authors.forename: S
authors.initials: S
authors.lastname: Bay
authors.forename: O
authors.initials: O
authors.lastname: Berthier-Vergnes
authors.forename: V
authors.initials: V
authors.lastname: Biberovic
authors.forename: D
authors.initials: D
authors.lastname: Cantacuzène
mesh_terms: D000957:Antigens, Viral, Tumor / Q000737:chemistry*; D019921:Biotinylation; D002236:Carbohydrate Conformation; D002240:Carbohydrate Sequence; D007769:Lactams / Q000737:chemistry; D037102:Lectins / Q000032:analysis; D015335:Molecular Probes; D008969:Molecular Sequence Data; D012694:Serine / Q000737:chemistry*
chemical_list: D000957:Antigens, Viral, Tumor; D007769:Lactams; D037102:Lectins; D015335:Molecular Probes; D012694:Serine