title: Overrepresentation of 1q21-23 and 12q13-21 in lipoma-like liposarcomas but not in benign lipomas: a comparative genomic hybridization study.
abstract: Twenty lipomatous tumors, including eight lipoma-like liposarcomas and 12 benign lipomas, were analyzed using comparative genomic hybridization (CGH). DNA sequence copy number changes detected in five lipoma-like liposarcomas (mean, 1.1 aberrations/tumor; range, 0-2) consisted of gains of 12q13-21 (five tumors) and 1q21-23 (four tumors). Two of the tumors showed high-level amplification at 12q14-21 and one tumor at 1q21-22. No copy number changes were found in lipomas. Overrepresentation of 1q and 12q sequences was a recurrent finding in lipoma-like liposarcomas but not in lipomas. Thus, CGH may help in the differential diagnosis of low-grade or borderline adipose neoplasms.
authors.affiliation: Department of Medical Genetics, Haartman Institute, University of Helsinki, Finland.
authors.forename: J
authors.initials: J
authors.lastname: Szymanska
authors.forename: M
authors.initials: M
authors.lastname: Virolainen
authors.forename: M
authors.initials: M
authors.lastname: Tarkkanen
authors.forename: T
authors.initials: T
authors.lastname: Wiklund
authors.forename: S
authors.initials: S
authors.lastname: Asko-Seljavaara
authors.forename: E
authors.initials: E
authors.lastname: Tukiainen
authors.forename: I
authors.initials: I
authors.lastname: Elomaa
authors.forename: C
authors.initials: C
authors.lastname: Blomqvist
authors.forename: S
authors.initials: S
authors.lastname: Knuutila
mesh_terms: D000328:Adult; D000368:Aged; D002878:Chromosomes, Human, Pair 1; D002881:Chromosomes, Human, Pair 12; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D017403:In Situ Hybridization / Q000379:methods*; D008067:Lipoma / Q000235:genetics*; D008080:Liposarcoma / Q000235:genetics*; D008297:Male; D008875:Middle Aged