title: [Inefficacy of exchange-transfusion in case of a methotrexate poisoning].
abstract: We report on a case of methotrexate (MTX) intoxication occurring in a 19-year-old man treated for a leukemia. Exchange-transfusion (ET) was performed in attempt to remove the MTX from the body. This exchange-transfusion was unable to decrease the MTX plasma concentration. This inefficacy of ET in MTX intoxication is in contradiction with previously reported recommendations. However, this result is easily explained by MTX pharmacokinetics parameters.
authors.affiliation: Service de pharmacologie clinique, Centre Midi-Pyrénées de pharmacovigilance, de pharmacoépidémiologie et d'informations sur le médicament, Faculté de médecine, Toulouse, France.
authors.forename: S
authors.initials: S
authors.lastname: Bénézet
authors.forename: E
authors.initials: E
authors.lastname: Chatelut
authors.forename: H
authors.initials: H
authors.lastname: Bagheri
authors.forename: F
authors.initials: F
authors.lastname: Rigal-Huguet
authors.forename: L
authors.initials: L
authors.lastname: Nguyen
authors.forename: J
authors.initials: J
authors.lastname: Pourrat
authors.forename: A
authors.initials: A
authors.lastname: Robert
authors.forename: J L
authors.initials: JL
authors.lastname: Montastruc
authors.forename: P
authors.initials: P
authors.lastname: Canal
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000628:therapy; D000328:Adult; D000931:Antidotes / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000506:poisoning*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D004232:Diuretics / Q000627:therapeutic use; D062787:Drug Overdose / Q000209:etiology / Q000628:therapy; D005078:Exchange Transfusion, Whole Blood; D005665:Furosemide / Q000627:therapeutic use; D006801:Humans; D002955:Leucovorin / Q000627:therapeutic use; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage / Q000097:blood / Q000506:poisoning*; D010198:Pancytopenia / Q000139:chemically induced; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy*; D017211:Treatment Failure
chemical_list: D000931:Antidotes; D000970:Antineoplastic Agents; D004232:Diuretics; D005665:Furosemide; D002955:Leucovorin; D008727:Methotrexate