[Changes in hemostasis and vagal tonus in healthy individuals and patients with facial neuropathy by micro-dose heparin stimulation of nasal receptors].
The effects of heparin microdoses on vagal tone (the Bayevsky heart rate variability index) and blood coagulation time were examined in 15 healthy men and women and in 14 patients with acute facial neuropathy. Nasal inhalation of heparin solution vapour (thrice every 30 sec, interrupted by a 60-80 sec interval) without changes in olfactory sensation or nasal secretion prolongs the onset and completion of blood clotting and decreased heart rate (vagal activation) in normotony volunteers. The similar procedure of distilled water nasal inhalation appears to be ineffective.
Uryvaev
I V
IV
Medical Academy of IM Sechenov, Moscow.
Iudel'son
I B
IB
Sergeev
V V
VV
D000208:Acute Disease; D000280:Administration, Inhalation; D000293:Adolescent; D000328:Adult; D000925:Anticoagulants / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D005156:Facial Neuralgia / Q000097:blood* / Q000503:physiopathology; D005260:Female; D006487:Hemostasis / Q000187:drug effects / Q000502:physiology*; D006493:Heparin / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D009666:Nose / Q000187:drug effects / Q000294:innervation; D013268:Stimulation, Chemical; D014630:Vagus Nerve / Q000187:drug effects / Q000502:physiology*
D000925:Anticoagulants; D006493:Heparin