The renal dopamine system.
Intrarenally formed dopamine induced natriuresis by inhibiting the activity of renal tubular Na/KATPase. This effect is mediated via a complex signal network, which includes inhibition of PP1 via the adenylyl cyclase-PKA-DARPP32 pathway and activation of PKC via the PLA2-arachidonic acid-20HETE pathway. The renal dopamine availability is a major determinant of the natriuretic effect of dopamine and is to a large extent modulated by the activity of COMT. The possibility that regulation of dopamine storage and release influences renal dopamine effects should be considered.
Aperia
A
A
Department of Woman and Child Health, St. Göran's Children's Hospital, Karolinska Institute, Stockholm, Sweden.
Eklöf
A C
AC
Holtbäck
U
U
Nowicki
S
S
Sundelöf
M
M
Greengard
P
P
D000262:Adenylyl Cyclases / Q000378:metabolism; D000818:Animals; D016718:Arachidonic Acid / Q000378:metabolism; D002394:Catechol O-Methyltransferase / Q000378:metabolism; D017868:Cyclic AMP-Dependent Protein Kinases / Q000378:metabolism; D004298:Dopamine / Q000502:physiology*; D051937:Dopamine and cAMP-Regulated Phosphoprotein 32; D006893:Hydroxyeicosatetraenoic Acids / Q000378:metabolism; D007668:Kidney / Q000502:physiology*; D007684:Kidney Tubules / Q000201:enzymology; D009318:Natriuresis; D009419:Nerve Tissue Proteins / Q000378:metabolism; D010741:Phospholipases A / Q000378:metabolism; D054467:Phospholipases A2; D010750:Phosphoproteins / Q000378:metabolism; D015398:Signal Transduction; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism
D051937:Dopamine and cAMP-Regulated Phosphoprotein 32; D006893:Hydroxyeicosatetraenoic Acids; D009419:Nerve Tissue Proteins; D010750:Phosphoproteins; D016718:Arachidonic Acid; C055987:20-hydroxy-5,8,11,14-eicosatetraenoic acid; D002394:Catechol O-Methyltransferase; D017868:Cyclic AMP-Dependent Protein Kinases; D010741:Phospholipases A; D054467:Phospholipases A2; D000262:Adenylyl Cyclases; D000254:Sodium-Potassium-Exchanging ATPase; D004298:Dopamine