title: Hepatic undifferentiated (embryonal) sarcoma arising in a mesenchymal hamartoma.
abstract: We report the case of a hepatic undifferentiated (embryonal) sarcoma (UES) arising within a mesenchymal hamartoma (MH) in a 15-year-old girl. Mapping of the tumor demonstrated a typical MH transforming gradually into a UES composed of anaplastic stromal cells. When evaluated by flow cytometry, the MH was diploid and the UES showed a prominent aneuploid peak. Karyotypic analysis of the UES showed structural alterations of chromosome 19, which have been implicated as a potential genetic marker of MH. The histogenesis of MH and UES is still debated, and reports of a relationship between them, although suggested on the basis of histomorphologic similarities, have never been convincing. The histologic, flow cytometric, and cytogenetic evidence reported herein suggests a link between these two hepatic tumors of the pediatric population.
authors.affiliation: Department of Pathology and Laboratory Medicine, University of Florida College of Medicine, Gainesville 32610, USA.
authors.forename: G Y
authors.initials: GY
authors.lastname: Lauwers
authors.forename: L D
authors.initials: LD
authors.lastname: Grant
authors.forename: W H
authors.initials: WH
authors.lastname: Donnelly
authors.forename: A M
authors.initials: AM
authors.lastname: Meloni
authors.forename: R M
authors.initials: RM
authors.lastname: Foss
authors.forename: A A
authors.initials: AA
authors.lastname: Sanberg
authors.forename: M R
authors.initials: MR
authors.lastname: Langham
mesh_terms: D000293:Adolescent; D014408:Biomarkers, Tumor / Q000032:analysis; D005260:Female; D005434:Flow Cytometry; D006222:Hamartoma / Q000737:chemistry / Q000000981:diagnostic imaging / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D007621:Karyotyping; D008113:Liver Neoplasms / Q000737:chemistry / Q000000981:diagnostic imaging / Q000473:pathology*; D008648:Mesoderm / Q000737:chemistry / Q000000981:diagnostic imaging / Q000473:pathology*; D009373:Neoplasms, Germ Cell and Embryonal / Q000737:chemistry / Q000000981:diagnostic imaging / Q000473:pathology*; D011003:Ploidies; D012509:Sarcoma / Q000737:chemistry / Q000000981:diagnostic imaging / Q000473:pathology*; D014057:Tomography, X-Ray Computed
chemical_list: D014408:Biomarkers, Tumor