Effect of inflammation on measures of antioxidant status in patients with non-small cell lung cancer.
This study examined the effect of an inflammatory response on measures of antioxidant status in patients with non-small cell lung cancer (NSCLC). In healthy, control subjects (n = 13) and NSCLC patients (n = 22) fasting concentrations of albumin, C-reactive protein, cholesterol, and the antioxidants alpha-tocopherol, retinol, lutein, lycopene, and alpha- and beta-carotene were measured. The two groups were similar in terms of age, sex, and body mass index. However, the cancer group had an inflammatory response as evidenced by significantly increased C-reactive protein concentrations. Concentrations of all the measured antioxidants of the NSCLC group were significantly lower than those of the control group (P < 0.01). The lowest concentrations were those of the carotenoids lycopene and alpha- and beta-carotene. In the cancer group there were significant negative correlations between concentrations of C-reactive protein and retinol (r = -0.682, P < 0.01), alpha-tocopherol (r = -0.464, P < 0.05), and lutein (r = -0.599, P < 0.01). The results of this study have implications for the interpretation of circulating antioxidant concentrations in patients with NSCLC.
Talwar
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Department of Human Nutrition, Royal Infirmary, Glasgow, United Kingdom.
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T K
TK
Scott
H R
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Cooney
J
J
Fell
G S
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O'Reilly
D S
DS
Lean
M E
ME
McMillan
D C
DC
D000368:Aged; D000369:Aged, 80 and over; D000975:Antioxidants / Q000378:metabolism*; D002097:C-Reactive Protein / Q000378:metabolism; D002289:Carcinoma, Non-Small-Cell Lung / Q000097:blood* / Q000276:immunology; D016022:Case-Control Studies; D005215:Fasting / Q000097:blood; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood*; D008175:Lung Neoplasms / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging
D000975:Antioxidants; D002097:C-Reactive Protein