[The embryotoxic and teratogenic action of some brands of epoxy resins].
The studies made permit stating that such epoxy resins as DE-500 with dose levels of 1/10 and 1/50 DL50, DE-1000 with 1/10, 1/50, 1/100, 1/250 DL50, UP-650, UP-650T with 1/10 DL50 administered into the stomach of pregnant females of nondescript albino rats from the 1st to the 19th day of pregnancy (DL50 being 5338 +/- 1134, 6644 +/- 1114, 9180 +/- 1154, 7717 +/- 586, 6980 +/- 621 mg/kg for the resins DE-500, DE-1000, DE-2000, UP-650, UP-650T respectively) have embryotoxic as well as teratogenic effects. The embryotoxic effect of the above epoxy resins depends on the dose administered and their chemical structure. These same embryotoxic and teratogenic effects a need to be taken into consideration in scientific substantiation/revision of hygienic regulations for polyoxipropilene diepoxides and alicyclic epoxy resins.
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D000284:Administration, Oral; D000818:Animals; D001755:Blastocyst / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004622:Embryo, Mammalian / Q000187:drug effects*; D004853:Epoxy Resins / Q000008:administration & dosage / Q000633:toxicity*; D005260:Female; D007928:Lethal Dose 50; D011247:Pregnancy; D051381:Rats; D013723:Teratogens / Q000633:toxicity*
D004853:Epoxy Resins; D013723:Teratogens