New developments in drug therapy of hypertension.
The explosion of new knowledge about the complex mechanisms mediating high blood pressure is providing new targets for drug therapy of hypertension and other cardiovascular disorders. This article reviews the current status of several new approaches in the management of hypertension, including vasopressin antagonists, natriuretic peptide clearance inhibitors, endothelin antagonists, renin inhibitors, angiotensin receptor antagonists, and selective T-type calcium ion channel antagonists.
Kobrin
I
I
Department of Clinical Development, Hoffmann-LaRoche, Nutley, New Jersey, USA.
Charlon
V
V
Bursztyn
M
M
D000818:Animals; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001127:Arginine Vasopressin / Q000037:antagonists & inhibitors; D009320:Atrial Natriuretic Factor / Q000378:metabolism / Q000502:physiology; D016232:Endothelins / Q000037:antagonists & inhibitors; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*
D000959:Antihypertensive Agents; D016232:Endothelins; D001127:Arginine Vasopressin; D009320:Atrial Natriuretic Factor