[Hyperplastic follicular response of the regional lymph nodes in cancer (immunohistochemistry, ultrastructure, prognostic importance)].
194 regional lymph nodes surgically removed because of cancer at various sites from 60 cancer patients are studied immunohistochemically and ultrastructurally. Monoclonal antibodies (MCAB) against antigens CD 1, CD 2, CD 3, CD 4, CD 8, CD 10, CD 19, CD 20, CD 30, CD 45, CD 56, BLA-36 were used for differentiating lymphoid cells. MCAB against alpha 1-antichymotrypsin, lysozyme, S100 protein, desmin, pan-cytokeratin, vimentin, laminin, collagen type IV, factor VIII; CD 35 were used as markers of non-lymphoid cells. Immunohistochemical classification of the hyperplastic follicular reaction is proposed: 1) typical B-cell follicle; 2) B-cell follicle with high content of T- and NK-cells; a) with domination of helper-inducer subpopulation, b) with domination of killer-suppressor sub-population; III) T-cell follicle; IV) non-lymphoid cell follicle. It was established that type I and IV follicular reaction correlates with a low 5-year survival, while type IIb and III. hyperplasia correlates with a favourable prognosis.
Tsyplakov
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DE
Petrov
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SV
D000911:Antibodies, Monoclonal; D001402:B-Lymphocytes / Q000473:pathology; D006801:Humans; D006965:Hyperplasia; D007150:Immunohistochemistry; D008198:Lymph Nodes / Q000473:pathology* / Q000648:ultrastructure; D008207:Lymphatic Metastasis; D008854:Microscopy, Electron; D009369:Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000648:ultrastructure; D011379:Prognosis; D013601:T-Lymphocytes / Q000473:pathology
D000911:Antibodies, Monoclonal