Integrin signaling: specificity and control of cell survival and cell cycle progression.
Integrin-mediated adhesion to the extracellular matrix plays an important role in regulating cell survival and proliferation. There is now increasing evidence that integrins activate shared as well as subgroup-specific signaling pathways. The signals from these adhesion receptors are integrated with those originating from growth factor and cytokine receptors in order to organize the cytoskeleton, stimulate mitogen-activated protein kinase cascades, and regulate immediate early gene expression. The repertoire of integrins and composition of the extracellular matrix appear to dictate whether a cell will survive, proliferate or exit the cell cycle and differentiate in response to soluble factors.
Giancotti
F G
FG
Cellular Biochemistry and Biophysics Program, Memorial Sloan-Kettering Cancer Center, Cornell University, New York, NY 10021, USA. f-giancotti@ski.mskcc.org
D000818:Animals; D002453:Cell Cycle / Q000502:physiology*; D002470:Cell Survival / Q000502:physiology; D004847:Epithelial Cells / Q000502:physiology; D005347:Fibroblasts / Q000502:physiology; D016023:Integrins / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*
D016023:Integrins