title: Effect of intraluminal thrombus on abdominal aortic aneurysm wall stress.
abstract: OBJECTIVE
  Abdominal aortic aneurysms (AAAs) rupture when the wall stress exceeds the strength of the vascular tissue. Intraluminal thrombus may absorb tension and reduce AAA wall stress. This study was performed to test the hypothesis that intraluminal thrombus can significantly reduce AAA wall stress.
  
  
  METHODS
  AAA wall stresses were determined by axisymmetric finite element analysis. Model AAAs had external diameters ranging from 2.0 to 4.0 cm. Model parameters included: AAA length, 6 cm; wall thickness, 1.5 mm; Poisson's ratio, 0.49; Young's modulus, 1.0 MPa; and luminal pressure, 1.6 x 10(5) dyne/cm2. Stresses were calculated for each model without thrombus, and then were recalculated with thrombus filling 10% of the AAA cavity. Calculations were repeated as thrombus size was increased in 10% increments and as thrombus elastic modulus increased from 0.01 MPa to 1.0 MPa. Maximum wall stresses were compared between models that had intraluminal thrombus and the unmodified models. Stress reduction greater than 25% was considered significant.
  
  
  RESULTS
  The maximum stress reduction of 51% occurred when thrombus with elastic modulus of 1.0 MPa filled the entire AAA cavity. Stresses were reduced by only 25% as modulus decreased to 0.2 MPa. Similarly, decreasing thrombus size by 70% resulted in stress reduction of only 28%. Large AAAs experienced greater stress reduction than small AAAs (48% vs 11%).
  
  
  CONCLUSIONS
  Intraluminal thrombus can significantly reduce AAA wall stress.
authors.affiliation: Department of Biomathematics, University of California-Los Angeles School of Medicine, USA.
authors.forename: W R
authors.initials: WR
authors.lastname: Mower
authors.forename: W J
authors.initials: WJ
authors.lastname: Quiñones
authors.forename: S S
authors.initials: SS
authors.lastname: Gambhir
mesh_terms: D001012:Aorta, Abdominal / Q000503:physiopathology*; D017544:Aortic Aneurysm, Abdominal / Q000150:complications / Q000503:physiopathology*; D003198:Computer Simulation; D004548:Elasticity; D006801:Humans; D008955:Models, Cardiovascular; D013314:Stress, Mechanical; D013927:Thrombosis / Q000150:complications* / Q000503:physiopathology