title: Effect of nebulised lignocaine on the quality of induction of anaesthesia in cigarette smokers.
abstract: We have assessed the effect of nebulised lignocaine, given pre-operatively, upon the quality of induction of anaesthesia in cigarette smokers. Seventy-five patients were studied in a double-blind randomised fashion, receiving a nebuliser of either 4 ml 0.9% NaCl or 4 ml 4% lignocaine. All patients received a standardised anaesthetic consisting of thiopentone followed by progressive increments of enflurane. Thirty-three out of 38 patients (87%) who received nebulised lignocaine had induction without adverse events, compared with 25 out of 37 patients (68%) in the nebulised saline group (Chi-squared test p < 0.05). We conclude that the use of nebulised lignocaine, administered pre-operatively, improves the quality of induction of anaesthesia in cigarette smokers.
authors.affiliation: University Department of Anaesthesia, Leicester Royal Infirmary, UK.
authors.forename: R
authors.initials: R
authors.lastname: Caranza
authors.forename: J H
authors.initials: JH
authors.lastname: Raphael
authors.forename: N
authors.initials: N
authors.lastname: Nandwani
authors.forename: J A
authors.initials: JA
authors.lastname: Langton
mesh_terms: D000280:Administration, Inhalation; D000328:Adult; D000368:Aged; D000768:Anesthesia, General; D000779:Anesthetics, Local / Q000494:pharmacology*; D004311:Double-Blind Method; D006801:Humans; D008012:Lidocaine / Q000494:pharmacology*; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D011229:Preanesthetic Medication; D012120:Respiration Disorders / Q000209:etiology / Q000517:prevention & control*; D012907:Smoking / Q000009:adverse effects*
chemical_list: D000779:Anesthetics, Local; D008012:Lidocaine; D010100:Oxygen