title: Arterial ketone body ratio during hepatectomy.
abstract: The arterial ketone body ratio (AKBR) has been proposed as an accurate indicator of liver mitochondrial redox potential. However, the efficacy of the AKBR as a biochemical marker has been recently called into question. To resolve this issue, we studied the effect of temporary vascular occlusion on the AKBR during hepatectomy. Twenty patients undergoing hepatectomy were divided into two groups: those with hepatocellular carcinoma with a history of hepatic cirrhosis (n = 10; cirrhotic group) and those with liver disease without cirrhosis (n = 10; non-cirrhotic group). To minimize blood loss during hepatectomy, temporary vascular occlusion was applied using the Pringle maneuver. Acetoacetate and beta-hydroxybutyrate concentrations in the arterial blood and the AKBR were determined before and after vascular occlusion. In 25% of the two groups combined, the AKBR increased following normothermic ischemia, as compared with the levels prior to clamping; in 20% of cases in the cirrhotic group, it increased immediately following reperfusion, as compared with the levels prior to clamping. Changes in the AKBR during hepatectomy did not correlate with preoperative hepatocellular function. An AKBR of less than 0.7 prior to clamping which persisted during surgery was not a consistent risk factor for postoperative complications. The AKBR was not a useful predictor of liver viability in partial liver resection with temporary vascular occlusion.
authors.affiliation: Department of Surgery, Nagano Red Cross Hospital, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Hanazaki
authors.forename: M
authors.initials: M
authors.lastname: Wakabayashi
authors.forename: H
authors.initials: H
authors.lastname: Sodeyama
authors.forename: Y
authors.initials: Y
authors.lastname: Sode
authors.forename: N
authors.initials: N
authors.lastname: Kawamura
authors.forename: T
authors.initials: T
authors.lastname: Miyazaki
authors.forename: M
authors.initials: M
authors.lastname: Ohtsuka
mesh_terms: D020155:3-Hydroxybutyric Acid; D000090:Acetoacetates / Q000097:blood; D006528:Carcinoma, Hepatocellular / Q000097:blood / Q000601:surgery; D016022:Case-Control Studies; D005260:Female; D006498:Hepatectomy; D006801:Humans; D006885:Hydroxybutyrates / Q000097:blood; D007432:Intraoperative Period; D007657:Ketone Bodies / Q000097:blood*; D008103:Liver Cirrhosis / Q000097:blood / Q000601:surgery; D008113:Liver Neoplasms / Q000097:blood / Q000601:surgery; D008297:Male; D008875:Middle Aged
chemical_list: D000090:Acetoacetates; D006885:Hydroxybutyrates; D007657:Ketone Bodies; D020155:3-Hydroxybutyric Acid