Effects of occupational lead and cadmium exposure on some immunoregulatory cytokine levels in man.
The levels of serum interleukin-1beta (IL-1beta), interleukin-2 (IL-2), tumor necrosis factor alpha (TNF-alpha) and gamma-interferon (gamma-IFN) were assessed in the workers who were occupationally exposed to lead and cadmium. The values were compared with the age-matched control group. Blood lead and cadmium levels were significantly raised. Our findings suggest that chronic lead and cadmium exposure in humans resulted in significant suppression of the serum IL-1beta level, but did not alter IL-2 and TNF-alpha levels. The gamma-IFN level was also reduced in lead workers. In contrast, a significant enhancement was observed in the cadmium-exposed group. We conclude from these results that lead and cadmium exposure at chronically high level may affect some cytokine levels in humans.
Yücesoy
B
B
Department of Toxicology, Faculty of Pharmacy, Ankara University, Tandŏgan, Turkey.
Turhan
A
A
Ure
M
M
Imir
T
T
Karakaya
A
A
D000328:Adult; D002104:Cadmium / Q000009:adverse effects* / Q000097:blood; D016207:Cytokines / Q000097:blood*; D019652:Extraction and Processing Industry; D006801:Humans; D007371:Interferon-gamma / Q000097:blood; D007375:Interleukin-1 / Q000097:blood; D007376:Interleukin-2 / Q000097:blood; D007854:Lead / Q000009:adverse effects* / Q000097:blood; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure / Q000009:adverse effects*; D013054:Spectrophotometry, Atomic; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D016207:Cytokines; D007375:Interleukin-1; D007376:Interleukin-2; D014409:Tumor Necrosis Factor-alpha; D002104:Cadmium; D007854:Lead; D007371:Interferon-gamma