Evaluation of the genotoxic potential of alkylalkanolamines.
Three alkylalkanolamines, N,N-dimethylethanolamine, N-methyldiethanolamine, and tert-butyldiethanolamine, were evaluated for potential genotoxic activity using the Salmonella/microsome reverse gene mutation test, the CHO/HGPRT forward gene mutation test, a sister chromatid exchange test in cultured CHO cells, and an in vivo peripheral blood micronucleus test in Swiss-Webster mice. None of the three alkylalkanolamines produced any significant or dose-related increases in the frequencies of mutations, sister chromatid exchanges or micronuclei. These results indicate that N,N-dimethylethanolamine, N-methyldiethanolamine, and tert-butyldiethanolamine are not genotoxic in the tests conducted.
Leung
H W
HW
Union Carbide Corporation, Danbury, CT 06817-0001, USA.
Ballantyne
B
B
D000818:Animals; D016466:CHO Cells; D006224:Cricetinae; D003642:Deanol / Q000493:pharmacokinetics / Q000633:toxicity*; D004983:Ethanolamines / Q000493:pharmacokinetics / Q000633:toxicity*; D005260:Female; D007041:Hypoxanthine Phosphoribosyltransferase / Q000235:genetics; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D015162:Micronucleus Tests / Q000379:methods; D008862:Microsomes, Liver / Q000378:metabolism; D009152:Mutagenicity Tests / Q000379:methods; D009153:Mutagens / Q000493:pharmacokinetics / Q000633:toxicity*; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics; D012854:Sister Chromatid Exchange / Q000187:drug effects / Q000235:genetics
D004983:Ethanolamines; D009153:Mutagens; C104208:tert-butyldiethanolamine; D003642:Deanol; C008430:N-methyldiethanolamine; D007041:Hypoxanthine Phosphoribosyltransferase