Effects of anesthetic technique on the hemodynamic response to microlaryngeal surgery.
Our aim was to study the attenuation of the hemodynamic response to microlaryngeal surgery by beta-blocking agents used as support drugs to the anesthetic technique. The study was carried out in 30 patients randomly allocated to one of three groups. The control group received only anesthetic drugs. The second group received labetalol hydrochloride 0.3 mg/kg 3 minutes before induction and 0.15 mg/ kg 2 minutes prior to the start of suspension of the larynx. The third group received esmolol hydrochloride 500 micrograms/kg 3 minutes prior to induction and a continuous infusion of 300 micrograms/kg during the surgical procedure. Hemodynamic data in the three groups were compared by analysis of variance. A statistically significant difference (p < .05) was found in hemodynamic data among the two groups treated with blocking agents and the control group. The addition of beta-blocking agents to the anesthetic technique attenuates the hemodynamic response to suspension laryngoscopy.
Ayuso
A
A
Department of Anesthesiology, University of Barcelona, Spain.
Luis
M
M
Sala
X
X
Sánchez
J
J
Traserra
J
J
D000317:Adrenergic alpha-Antagonists / Q000627:therapeutic use*; D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D000328:Adult; D000771:Anesthesia, Intravenous / Q000379:methods*; D001784:Blood Gas Analysis; D004724:Endoscopy / Q000009:adverse effects*; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D007741:Labetalol / Q000627:therapeutic use*; D007822:Laryngeal Neoplasms / Q000503:physiopathology / Q000601:surgery*; D007828:Laryngoscopy / Q000009:adverse effects*; D008297:Male; D008866:Microsurgery / Q000009:adverse effects*; D008875:Middle Aged; D016343:Monitoring, Intraoperative; D011412:Propanolamines / Q000627:therapeutic use*
D000317:Adrenergic alpha-Antagonists; D000319:Adrenergic beta-Antagonists; D011412:Propanolamines; C036604:esmolol; D007741:Labetalol