Inhibition of the Ser-Thr phosphatases PP1 and PP2A by naturally occurring toxins.
The okadaic acid class of naturally occurring toxins is a structurally diverse group of molecules that inhibit the protein phosphatases PP1 and PP2A. Studies providing information about the mode of binding between the toxins and the phosphatases contribute to an overall understanding of the signal transduction pathways in which the phosphatases are involved.
Sheppeck
J E
JE
Department of Chemistry, University of California at Irvine 92697, USA.
Gauss
C M
CM
Chamberlin
A R
AR
D000595:Amino Acid Sequence; D004791:Enzyme Inhibitors / Q000494:pharmacology; D008969:Molecular Sequence Data; D016297:Mutagenesis, Site-Directed; D019319:Okadaic Acid / Q000494:pharmacology; D010749:Phosphoprotein Phosphatases / Q000037:antagonists & inhibitors*; D011506:Proteins / Q000235:genetics / Q000502:physiology
D004791:Enzyme Inhibitors; D011506:Proteins; D019319:Okadaic Acid; D010749:Phosphoprotein Phosphatases