Pregnancy after intracytoplasmic sperm injection with sperm from a man with a 47,XXY Klinefelter's karyotype.
OBJECTIVE
To report the initiation of a pregnancy that was achieved by intracytoplasmic sperm injection (ICSI) with sperm from a patient with Klinefelter's syndrome.


METHODS
Case report.


METHODS
University women's hospital IVF center.


METHODS
A couple with primary infertility and nonmosaic 47,XXY karyotype of the male partner.


METHODS
Intracytoplasmic sperm injection after ovarian stimulation and transvaginal ultrasound-guided oocyte pick-up with sperm from a hypergonadotropic man with a nonmosaic 47,XXY karyotype.


METHODS
Clinical pregnancy.


RESULTS
Despite a 47,XXY karyotype in all 50 analyzed lymphocyte metaphases, the sperm of the patient led to a clinical pregnancy with the first attempt of ICSI and intrauterine transfer of three embryos. The pregnancy stopped developing in the ninth week. Cytogenetic investigation of the abortion material revealed a numerical normal 46,XXY karyotype.


CONCLUSIONS
Sperm from a patient with hypergonadotropic nonmosaic Klinefelter's syndrome, when used for ICSI, can lead to a pregnancy.
Hinney
B
B
University of Goettingen, Germany. BHINNEY@MED.UNI-GOETTINGEN.DE
Guttenbach
M
M
Schmid
M
M
Engel
W
W
Michelmann
H W
HW
D000028:Abortion, Induced; D000328:Adult; D003593:Cytoplasm; D005260:Female; D006801:Humans; D007621:Karyotyping; D007713:Klinefelter Syndrome / Q000235:genetics*; D008297:Male; D008845:Microinjections; D008846:Micromanipulation; D011247:Pregnancy; D013094:Spermatozoa