title: Vitamin C supplementation and the common cold--was Linus Pauling right or wrong?
abstract: In 1970 Linus Pauling claimed that vitamin C prevents and alleviates the episodes of the common cold. Pauling was correct in concluding from trials published up till then, that in general vitamin C does have biological effects on the common cold, but he was rather over-optimistic as regards the size of benefit. His quantitative conclusions were based on a single placebo-controlled trial on schoolchildren in a skiing camp in the Swiss Alps, in which a significant decrease in common cold incidence and duration in the group administered 1 g/day of vitamin C was found. As children in a skiing camp are not a representative sample of the general population, Pauling's extrapolation to the population at large was too bold, erring as to the magnitude of the effect. Nevertheless, Pauling's general conclusion that vitamin C has physiological effects on the common cold is of major importance as it conflicts with the prevailing consensus that the only physiological effect of vitamin C on human beings is to prevent scurvy.
authors.affiliation: Department of Public Health, University of Helsinki, Finland.
authors.forename: H
authors.initials: H
authors.lastname: Hemilä
mesh_terms: D001205:Ascorbic Acid / Q000008:administration & dosage / Q000494:pharmacology*; D002986:Clinical Trials as Topic; D003139:Common Cold / Q000453:epidemiology / Q000503:physiopathology / Q000517:prevention & control*; D019587:Dietary Supplements; D006801:Humans; D015994:Incidence; D012720:Severity of Illness Index
chemical_list: D001205:Ascorbic Acid