title: Genes coding for melanoma antigens recognised by cytolytic T lymphocytes.
abstract: It is now well established that human melanoma cells express antigens that are recognised by cytolytic T lymphocytes derived from the tumour-bearing patient. The molecular definition of these antigens is progressing at an accelerated pace. The currently characterised melanoma antigens can be classified into three categories: differentiation antigens, antigens encoded by genes that are specifically expressed in tumours, and antigens encoded by mutated genes. Several of these antigens are sufficiently tumour-specific to qualify them as candidate anti-cancer vaccines in melanoma patients.
authors.affiliation: Ludwig Institute for Cancer Research, Brussels branch, Belgium.
authors.forename: C
authors.initials: C
authors.lastname: De Smet
authors.forename: C
authors.initials: C
authors.lastname: Lurquin
authors.forename: E
authors.initials: E
authors.lastname: De Plaen
authors.forename: F
authors.initials: F
authors.lastname: Brasseur
authors.forename: H
authors.initials: H
authors.lastname: Zarour
authors.forename: O
authors.initials: O
authors.lastname: De Backer
authors.forename: P G
authors.initials: PG
authors.lastname: Coulie
authors.forename: T
authors.initials: T
authors.lastname: Boon
mesh_terms: D000941:Antigens / Q000235:genetics; D000945:Antigens, Differentiation, T-Lymphocyte / Q000235:genetics; D000951:Antigens, Neoplasm / Q000235:genetics*; D005796:Genes; D006801:Humans; D007167:Immunotherapy; D008545:Melanoma / Q000276:immunology* / Q000628:therapy; D017354:Point Mutation; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*
chemical_list: D000941:Antigens; D000945:Antigens, Differentiation, T-Lymphocyte; D000951:Antigens, Neoplasm