Taming TNF: strategies to restrain this proinflammatory cytokine.
Recent studies have demonstrated the essential role of tumor necrosis factor alpha (TNF-alpha) in rheumatoid arthritis and Crohn's disease. This article discusses agents known to suppress the formation or activity of TNF-alpha, and summarizes clinical studies using anti-TNF-alpha antibodies.
Eigler
A
A
Medizinische Klinik, Klinikum Innenstadt der Ludwig-Maximilians-Universität, München, Germany.
Sinha
B
B
Hartmann
G
G
Endres
S
S
D000818:Animals; D000906:Antibodies / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000276:immunology / Q000628:therapy; D003424:Crohn Disease / Q000276:immunology / Q000628:therapy; D006801:Humans; D018836:Inflammation Mediators / Q000037:antagonists & inhibitors* / Q000502:physiology; D010726:Phosphodiesterase Inhibitors / Q000494:pharmacology; D018805:Sepsis / Q000276:immunology / Q000628:therapy; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors* / Q000502:physiology
D000906:Antibodies; D018836:Inflammation Mediators; D010726:Phosphodiesterase Inhibitors; D014409:Tumor Necrosis Factor-alpha