title: Cerebrovascular pathology in Alzheimer's disease: cause, effect or epiphenomenon?
abstract: Cerebrovascular pathology abounds in Alzheimer's disease. Changes in the endothelium, disruption of the blood-brain barrier and amyloid deposition in the cerebral blood vessels are almost universal in advanced cases. Do these changes represent the cause, the effect, or the consequences of a common pathogenesis of Alzheimer's disease? This volume addresses some of these issues by presenting new knowledge gained from a diversity of fields. Recognition of the mechanisms involved will open new possibilities for therapeutic trials.
authors.affiliation: Department of Clinical Neurological Sciences, London Health Sciences Center, University of Western Ontario, Canada.
authors.forename: V
authors.initials: V
authors.lastname: Hachinski
authors.forename: D G
authors.initials: DG
authors.lastname: Munoz
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000453:epidemiology / Q000235:genetics / Q000473:pathology*; D001812:Blood-Brain Barrier; D002536:Cerebral Arteries / Q000473:pathology; D002550:Cerebral Veins / Q000473:pathology; D002560:Cerebrovascular Circulation; D004730:Endothelium, Vascular / Q000473:pathology; D006801:Humans; D008833:Microcirculation