title: The effect of intravenous lidocaine injection on hearing thresholds.
abstract: The effect of intravenous injection of lidocaine on hearing thresholds was studied in normal subjects. Continuous and intermittent tones at 1, 4 and 8 kHz were used as stimuli and the threshold change with lidocaine injection was measured using a self-recording audiometer (Békésy audiometer). Both increases and decreases in the threshold were observed. The former occurred more frequently than the latter. In cases of a threshold increase, lidocaine injection exhibited a frequency specific effect; the higher the frequency, the more often the threshold was increased by lidocaine injection. There was no significant difference in threshold changes between continuous and intermittent tones. The present results suggest that lidocaine may act on the inner ear hair cells.
authors.affiliation: Department of Hearing and Speech Science, Faculty of Medicine, Kyoto University, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Shiomi
authors.forename: K
authors.initials: K
authors.lastname: Funabiki
authors.forename: Y
authors.initials: Y
authors.lastname: Naito
authors.forename: N
authors.initials: N
authors.lastname: Fujiki
authors.forename: J
authors.initials: J
authors.lastname: Tsuji
mesh_terms: D000328:Adult; D000779:Anesthetics, Local / Q000494:pharmacology*; D001301:Audiometry, Pure-Tone; D001309:Auditory Threshold / Q000187:drug effects*; D005260:Female; D006199:Hair Cells, Auditory, Inner / Q000187:drug effects; D006801:Humans; D007275:Injections, Intravenous; D008012:Lidocaine / Q000494:pharmacology*; D008297:Male; D010898:Pitch Perception / Q000187:drug effects
chemical_list: D000779:Anesthetics, Local; D008012:Lidocaine