title: Impact of age on the severity, course, and complications of alcohol withdrawal.
abstract: BACKGROUND
  Early identification of alcohol-dependent patients at increased risk for severe or complicated alcohol withdrawal would improve triage and treatment. However, the role of age in predicting alcohol withdrawal outcomes has not been well studied.
  
  
  OBJECTIVE
  To assess the impact of age on the severity, course, and complications of alcohol withdrawal.
  
  
  METHODS
  We performed a retrospective cohort study of 284 inpatients admitted for alcohol withdrawal between September 1992 and August 1994. Outcomes included alcohol withdrawal severity measured by the revised Clinical Institute Withdrawal Assessment for Alcohol scale, quantity and duration of benzodiazepine therapy, and complications during withdrawal.
  
  
  RESULTS
  Initial and maximal withdrawal severity scores, amount of benzodiazepine administered, and duration of benzodiazepine treatment for elevated withdrawal severity scores did not change significantly with age. However, patients aged 60 years and older had increased risk for delirium (adjusted odds ratio [OR], 4.7; 95% confidence interval [CI], 1.5-15.0; P = .008), falls (OR, 3.1; 95% CI, 0.9-11.2; P = .08), and transient dependency in 2 or more activities of daily living (OR, 5.8; 95% CI, 2.9-11.7; P < .001). As age increased, there were significant increases in length of stay (P < .001) and frequency of discharge to an extended care facility (P < .001).
  
  
  CONCLUSIONS
  Although alcohol withdrawal severity scores and benzodiazepine requirements were similar across age groups, patients aged 60 years and older were at increased risk for cognitive and functional impairment during withdrawal. These findings support recommendations that older patients with alcohol withdrawal are best treated in closely supervised settings.
authors.affiliation: Division of General Internal Medicine, Deaconess Hospital, Boston, Mass., USA.
authors.forename: K L
authors.initials: KL
authors.lastname: Kraemer
authors.forename: M F
authors.initials: MF
authors.lastname: Mayo-Smith
authors.forename: D R
authors.initials: DR
authors.lastname: Calkins
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000430:Alcohol Withdrawal Delirium / Q000150:complications* / Q000188:drug therapy; D014151:Anti-Anxiety Agents / Q000627:therapeutic use; D001569:Benzodiazepines; D005260:Female; D006801:Humans; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D012720:Severity of Illness Index
chemical_list: D014151:Anti-Anxiety Agents; D001569:Benzodiazepines