Apolipoprotein E and alpha 1-antichymotrypsin in dialysis-related amyloidosis.
Dialysis-related amyloidosis as represented by carpal tunnel syndrome is a serious complication of long-term dialysis treatment of patients with chronic renal failure. beta 2-microglobulin has been identified as a structural component of the amyloid deposits, but other factors also are associated with amyloid formation. We recently demonstrated the presence of apolipoprotein E and alpha 1-antichymotrypsin in the amyloid deposits. We therefore analyzed how polymorphic variants of both genes were related to the onset of amyloidosis. Among the apolipoprotein E genotypes, allele epsilon 2 represented a protective factor that delayed the onset of disease. In contrast, polymorphic alpha 1-antichymotrypsin alleles had no effect on the onset of amyloidosis. Thus, the apolipoprotein E epsilon 2 allele can be added to the list of factors that determine the onset of dialysis-related amyloidosis, which include patient age at initiation of dialysis therapy, dialysis duration, and the dialysis membrane used.
Gejyo
F
F
Department of Clinical and Laboratory Medicine, Fukui Medical School, Japan.
Kimura
H
H
Suzuki
S
S
Miyazaki
R
R
Naiki
H
H
Nakakuki
K
K
D000686:Amyloidosis / Q000209:etiology*; D001057:Apolipoproteins E / Q000235:genetics*; D015153:Blotting, Western; D002349:Carpal Tunnel Syndrome / Q000209:etiology; D017931:DNA Primers / Q000737:chemistry; D018572:Disease-Free Survival; D004591:Electrophoresis, Polyacrylamide Gel; D006801:Humans; D007676:Kidney Failure, Chronic / Q000628:therapy; D008297:Male; D006435:Renal Dialysis / Q000009:adverse effects*; D015842:Serine Proteinase Inhibitors / Q000235:genetics*; D013583:Synovial Membrane / Q000737:chemistry / Q000473:pathology; D000514:alpha 1-Antichymotrypsin / Q000235:genetics*
D001057:Apolipoproteins E; D017931:DNA Primers; D015842:Serine Proteinase Inhibitors; D000514:alpha 1-Antichymotrypsin