title: Patterning the Xenopus blastula.
abstract: This review starts from the classical standpoint that there are at least two separable processes acting with respect to axis formation and tissue specification in the early Xenopus embryo: a UV-insensitive event establishing a postgastrula embryo consisting of three concentric germ layers, ectoderm, mesoderm and endoderm, all of a ventral character; and a UV-sensitive event producing tissue of a dorsal type, including somites, notochord and neural tissue, and concomitantly establishing the dorsoventral and anteroposterior axes. The experimental evidence suggesting the molecular basis of the dorsal and ventral pathways is reviewed.
authors.affiliation: Institute of Human Genetics and Department of Cell Biology and Neuroanatomy, University of Minnesota School of Medicine, Minneapolis 55455, USA. heasman@lenti.med.umn.edu
authors.forename: J
authors.initials: J
authors.lastname: Heasman
mesh_terms: D000818:Animals; D019521:Body Patterning / Q000502:physiology*; D003598:Cytoskeletal Proteins / Q000502:physiology; D004625:Embryo, Nonmammalian / Q000187:drug effects / Q000528:radiation effects; D008954:Models, Biological; D015398:Signal Transduction; D015534:Trans-Activators; D014157:Transcription Factors / Q000378:metabolism; D016212:Transforming Growth Factor beta / Q000502:physiology; D014466:Ultraviolet Rays; D014981:Xenopus / Q000196:embryology* / Q000254:growth & development*; D029867:Xenopus Proteins; D051176:beta Catenin
chemical_list: C495266:CTNNB1 protein, Xenopus; D003598:Cytoskeletal Proteins; D015534:Trans-Activators; D014157:Transcription Factors; D016212:Transforming Growth Factor beta; D029867:Xenopus Proteins; D051176:beta Catenin