Mechanisms of growth failure in non-growth-hormone deficient children of short stature.
So far, the clinical evaluation of short children has focused on the measurement of immunoreactive growth hormone (GH) in the blood to determine if the growth retardation is due to GH deficiency. However, GH-dependent short stature may be caused by defects in either the secretion of bioactive GH or by the inability to respond to GH. Both GH secretion and GH responsiveness should, therefore, be evaluated when investigating the cause of short stature. Recent advances in molecular biology have generated new ways of studying different molecules involved in growth regulation, and new genetic defects have been identified in short children.
Boguszewski
C L
CL
Department of Internal Medicine, Sahlgrenska University Hospital, Göteborg, Sweden.
Carlsson
B
B
Carlsson
L M
LM
D002648:Child; D006130:Growth Disorders / Q000097:blood / Q000145:classification / Q000503:physiopathology*; D019382:Human Growth Hormone / Q000097:blood / Q000378:metabolism*; D006801:Humans; D018969:Insulin-Like Growth Factor Binding Proteins / Q000502:physiology; D007334:Insulin-Like Growth Factor I / Q000502:physiology; D008954:Models, Biological
D018969:Insulin-Like Growth Factor Binding Proteins; D019382:Human Growth Hormone; D007334:Insulin-Like Growth Factor I