Gamma delta T-cells in human cutaneous immunology.
Gamma delta T-Cells represent a minor subpopulation of T-lymphocytes in man and their role in normal and diseased human skin is unknown. This article is a comprehensive review of T-lymphocytes bearing the gamma delta T-cell receptor in normal and pathological human skin. Firstly, we have documented the occurrence of gamma delta T-cells in normal skin and in a range of reactive and malignant skin conditions. We have then discussed the experimental findings regarding the repertoire used by gamma delta T-cells in normal human skin and in cutaneous disorders with an increased percentage of gamma delta T-cells.
Alaibac
M
M
Dermatology Unit, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK.
Morris
J
J
Chu
A C
AC
D000818:Animals; D006801:Humans; D016773:Leishmaniasis, Cutaneous / Q000276:immunology / Q000473:pathology; D008206:Lymphatic Diseases / Q000276:immunology / Q000473:pathology; D051379:Mice; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000378:metabolism*; D012867:Skin / Q000166:cytology* / Q000276:immunology*; D012871:Skin Diseases / Q000276:immunology / Q000473:pathology; D012878:Skin Neoplasms / Q000276:immunology / Q000473:pathology; D016176:T-Lymphocyte Subsets / Q000276:immunology*
D016692:Receptors, Antigen, T-Cell, gamma-delta