Localization of manganese superoxide dismutase in the cerebral cortex and hippocampus of Alzheimer-type senile dementia.
Manganese-superoxide dismutase (Mn-SOD) was localized in the cerebral cortex and hippocampus of patients with Alzheimer-type senile dementia (ATD) by immunocytochemistry and the relationship of Mn-SOD with two major pathological features of ATD, i.e., senile plaques and neurofibrillar tangles (NFTs), was examined. Many astrocytes in senile plaques exhibited strong immunoreactivity for both Mn-SOD and glial fibrillar acidic protein (GFAP) on serial section analysis. This suggests that Mn-SOD scavenger system is associated with the formation of senile plaques. On the other hand, Mn-SOD immunoreactivity was not significant in NFT-loaded neurons.
Maeda
M
M
First Department of Anatomy, Osaka City University Medical School, Japan.
Takagi
H
H
Hattori
H
H
Matsuzaki
T
T
D000368:Aged; D000544:Alzheimer Disease / Q000201:enzymology*; D002540:Cerebral Cortex / Q000201:enzymology*; D005904:Glial Fibrillary Acidic Protein / Q000032:analysis; D006624:Hippocampus / Q000201:enzymology*; D006801:Humans; D007150:Immunohistochemistry; D013482:Superoxide Dismutase / Q000032:analysis*
D005904:Glial Fibrillary Acidic Protein; D013482:Superoxide Dismutase