Auxiliary heterotopic partial liver transplantation in pigs with acute ischemic liver failure.
OBJECTIVE
Fulminant hepatic failure (FHF) is usually fatal without liver transplantation. Auxiliary heterotopic partial liver transplantation (AHPLT) may offer advantages over orthotopic liver transplantation (OLT) or any other heterotopic procedure for the treatment of patients with fulminant liver failure. We studied AHPLT in a severe acute hepatic failure model in pigs.


METHODS
Group A (control: n = 5) underwent portal vein and hepatic artery ligation and side-to-side portocaval shunting. Group B (AHPLT: n = 15) underwent host portal vein and hepatic artery ligation and AHPLT.


RESULTS
All of the pigs in group A died within 48 hours from massive liver necrosis. Ten of the 15 pigs (67%) in group B had well-functioning grafts. Five of these ten died between 8 and 17 days postoperatively due to various complications. The remaining five survived for sixty days postoperatively in healthy condition. At the time of sacrifice, four of these five had well-functioning grafts weighing 739 +/- 52 g (mean +/- SEM) and regenerated, but still atrophied, host livers weighing 262 +/- 23 g (p < 0.0002). On the other hand, the one remaining pig had an atrophied graft weighing 310 g and a well-regenerated host liver weighing 470 g, probably due to a late, poorly functioning graft associated with severe rejection.


CONCLUSIONS
AHPLT may result in survival despite host hepatic failure, and the host liver may recover within two months, despite total interruption of blood inflow.
Nagashima
I
I
Transplant Service and Surgical Research Laboratory, Hartford Hospital, CT, USA.
Bergmann
L
L
Alsina
A E
AE
Schweizer
R T
RT
D000818:Animals; D005260:Female; D006499:Hepatic Artery; D006501:Hepatic Encephalopathy / Q000601:surgery*; D007511:Ischemia / Q000209:etiology / Q000601:surgery; D008026:Ligation; D016031:Liver Transplantation; D011169:Portal Vein; D013552:Swine; D016042:Transplantation, Heterotopic