Antibody response to influenza immunization in patients after heart transplantation.
The aim of this study was to evaluate post-heart transplantation (Htx) response to two-dose and three-dose influenza vaccine. Hemagglutination inhibition antibodies were monitored in HTx recipients immunized twice (n = 25) or three times (n = 17), and non-HTx controls (n = 8) once, with inactivated influenza vaccine. Post-first dose protective antibody titers (> or = 1:40) were demonstrated in 9/25 (36%) for A/Singapore/ (H1N1), 5/25 (20%) for A/Shanghai/(H3N2) and 2/25 (8%) for B/Yamagata compared with 4/8 (50%), 6/8 (75%) and 2/8 (25%), respectively, for controls. Post-second dose protective titers remained low, increasing following the third dose to 71%, 65% and 29%, respectively. The abnormally low antibody responses of HTx recipients to one-dose and two-dose influenza vaccine can be overcome by a third dose.
Admon
D
D
Department of Cardiology, Hadassah University Hospital, Jerusalem, Israel.
Engelhard
D
D
Strauss
N
N
Goldman
N
N
Zakay-Rones
Z
Z
D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000097:blood; D016027:Heart Transplantation / Q000276:immunology*; D006801:Humans; D007114:Immunization; D016867:Immunocompromised Host; D007252:Influenza Vaccines / Q000276:immunology*; D008297:Male; D008875:Middle Aged
D000914:Antibodies, Viral; D007252:Influenza Vaccines