title: The effect of flumazenil on subclinical psychometric or neurophysiological alterations in cirrhotic patients: a double-blind placebo-controlled study.
abstract: It is not yet clear if benzodiazepine receptor ligands, implicated in the pathophysiology of hepatic coma, also have a role in subclinical cognitive or neurophysiological alterations in cirrhotic patients. Therefore, we carried out a double-blind, placebo-controlled study to evaluate the effectiveness of flumazenil, a benzodiazepine antagonist, on brainstem auditory evoked responses and on the number connection test in cirrhotic patients with subclinical neurophysiological or cognitive alterations. Thirteen cirrhotic subjects with subclinical neurophysiological or cognitive alterations were studied. A total of 3 mg of flumazenil or saline was infused intravenously. Before and after the infusion, the number connection test was administered and brainstem auditory evoked responses recorded. After 72 h, patients were crossed over. Flumazenil did not influence brainstem auditory evoked responses or the number connection test. A screening test for benzodiazepines was negative in all subjects. We conclude that benzodiazepine receptor ligands have a negligible role, if any, in the pathophysiology of subclinical neurophysiological or cognitive alterations of cirrhotic patients.
authors.affiliation: Clinical Medicine II Department of Clinical and Experimental Medicine, University of Padua, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Amodio
authors.forename: P
authors.initials: P
authors.lastname: Marchetti
authors.forename: F
authors.initials: F
authors.lastname: Del Piccolo
authors.forename: A
authors.initials: A
authors.lastname: Beghi
authors.forename: F
authors.initials: F
authors.lastname: Comacchio
authors.forename: P
authors.initials: P
authors.lastname: Carraro
authors.forename: G
authors.initials: G
authors.lastname: Campo
authors.forename: L
authors.initials: L
authors.lastname: Baruzzo
authors.forename: C
authors.initials: C
authors.lastname: Marchiori
authors.forename: A
authors.initials: A
authors.lastname: Gatta
mesh_terms: D003071:Cognition / Q000187:drug effects; D003072:Cognition Disorders / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology; D004311:Double-Blind Method; D016057:Evoked Potentials, Auditory, Brain Stem / Q000187:drug effects; D005260:Female; D005442:Flumazenil / Q000494:pharmacology*; D058787:GABA-A Receptor Antagonists; D006501:Hepatic Encephalopathy / Q000188:drug therapy* / Q000209:etiology / Q000523:psychology; D006801:Humans; D008024:Ligands; D008103:Liver Cirrhosis / Q000150:complications / Q000503:physiopathology / Q000523:psychology*; D008297:Male; D008875:Middle Aged; D011594:Psychometrics; D011963:Receptors, GABA-A / Q000502:physiology
chemical_list: D058787:GABA-A Receptor Antagonists; D008024:Ligands; D011963:Receptors, GABA-A; D005442:Flumazenil