[The significance of the medical research study: hemodynamic and pathophysiologic characteristics in peripheral arterial reconstruction].
In cases of peripheral arterial reconstructive surgery, it is important to prevent postoperative early and late occlusion of the reconstructed artery. The postoperative early outcome of the reconstructed artery were related to electromagnetically determined flow waveform of the reconstructed artery. Flow waveform was classified in 5 types, i. e. types O, I, II, III, and IV. The prognosis of the reconstructed arteries with types O and I was excellent. Type II showed no postoperative early occlusion but late occlusion did occur in 31%. Type III and IV were all failed within 48 hours postoperatively. Correlation between prognosis of the reconstructed artery and flow waveform was established by the intraluminal velocity profile of blood flow, using a specially designed flow wave simulation pump system. Postoperative late occlusion in arterial reconstruction often occurs in cases with poor distal runoff and caused by intimal hyperplasia of implanted autovein graft and its distal end-to-side anastomosis. The features of intimal hyperplasia of the implanted autovein graft differed from those at the distal end-to-side anastomosis; the former being related to active proliferation of smooth muscle cells while the latter displayed an excessive proliferation of fibroblasts and collagen fibers.
Kusaba
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Department of Surgery II, Faculty of Medecine, University of Ryukyus, Okinawa, Japan.
D001157:Arterial Occlusive Diseases / Q000601:surgery*; D001158:Arteries / Q000601:surgery; D006439:Hemodynamics; D006801:Humans; D007866:Leg / Q000098:blood supply*; D009131:Muscle, Smooth, Vascular / Q000166:cytology; D011183:Postoperative Complications; D011379:Prognosis