Inductive interactions underlie neural crest formation.
The data summarized here indicate that (1) the neural crest can arise by means of inductive interaction between the neural and nonneural ectoderm; (2) initially, progenitor cells are multipotent, having the potential to form multiple ectodermal derivatives (epidermis, neural crest, and neural tube derivatives); and (3) with time, the precursors become progressively restricted to form neural crest derivatives and eventually to individual phenotypes.
Bronner-Fraser
M
M
Division of Biology, California Institute of Technology, Pasedena 91125, USA.
D000818:Animals; D001921:Brain / Q000196:embryology*; D002454:Cell Differentiation; D004475:Ectoderm / Q000166:cytology / Q000502:physiology; D009432:Neural Crest / Q000166:cytology / Q000502:physiology*; D013116:Spinal Cord / Q000196:embryology*; D013234:Stem Cells / Q000502:physiology; D014714:Vertebrates