NLPR, an agonist of AVP4-8, increases NGF gene expression in memory-impaired rat brain.
Oral administration of the tetrapeptide Asn-Leu-Pro-Arg (NLPR) to memory-impaired rats results in improved acquisition and maintenance of behavioural response and also facilitates nerve growth factor (NGF) expression in the brain. It is suggested that NLPR can ameliorate memory disability by promoting NGF gene expression, so implying that NLPR is a potential drug candidate for curing memory impairment.
Zhou
A W
AW
Shanghai Institute of Biochemistry, Academia Sinica, China.
Guo
J
J
Du
Y C
YC
D000818:Animals; D001127:Arginine Vasopressin / Q000819:agonists*; D001921:Brain / Q000378:metabolism* / Q000503:physiopathology; D005260:Female; D005786:Gene Expression Regulation / Q000187:drug effects*; D008569:Memory Disorders / Q000235:genetics / Q000378:metabolism*; D009414:Nerve Growth Factors / Q000096:biosynthesis* / Q000235:genetics; D009842:Oligopeptides / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D009414:Nerve Growth Factors; D009842:Oligopeptides; C108849:asparaginyl-leucyl-prolyl-arginine; D001127:Arginine Vasopressin