Risk factors for Alzheimer's disease: a case-control study.
The extent of current knowledge of risk factors for Alzheimer's disease (AD) is still limited. We conducted a case-control study of 98 AD patients and 98 age- and sex-matched controls. Light smoking had a decreased risk for AD (AD: 2.0%, controls: 21.4%, odds ratio = 0.10, p = 0.003), whereas daily smoking showed a trend to increase the risk for AD (AD: 45.9%, controls: 26.5%, odds ratio = 1.73, p = 0.08). After multivariable analyses factors associated with AD included the presence of apolipoprotein epsilon4 allele, and the duration of well water consumption.
Wang
P N
PN
Neurology, Neurological Institute, Veterans General Hospital Taipei and National Yang-Ming University School of Medicine, Taiwan.
Wang
S J
SJ
Hong
C J
CJ
Liu
T T
TT
Fuh
J L
JL
Chi
C W
CW
Liu
C Y
CY
Liu
H C
HC
D000368:Aged; D000483:Alleles; D000544:Alzheimer Disease / Q000175:diagnosis / Q000209:etiology / Q000235:genetics*; D001057:Apolipoproteins E / Q000235:genetics; D016022:Case-Control Studies; D005260:Female; D005838:Genotype; D015386:Hazardous Substances / Q000009:adverse effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects; D014867:Water / Q000009:adverse effects
D001057:Apolipoproteins E; D015386:Hazardous Substances; D014867:Water