title: Dynamic autoregulation and renal injury in Dahl rats.
abstract: The Dahl salt-sensitive (Dahl S) rat develops hypertension and renal injuries when challenged with a high salt diet and has been considered to be a model of chronic renal failure. Renal injuries appear very early in life compared with the spontaneously hypertensive rat (SHR). During the course of hypertension, a gradual impairment of autoregulatory control of renal blood flow might expose the glomerular circulation to periods of elevated pressure, resulting in renal injuries in Dahl S rats. Dynamic autoregulatory capacity was assessed in Dahl S and Dahl salt-resistant (Dahl R) rats, SHR, and Sprague-Dawley rats by inducing broad-band fluctuations in the arterial blood pressure and simultaneously measuring renal blood flow. Dynamic autoregulation was estimated by the transfer function using blood pressure as the input and renal blood flow as the output. Renal morphological injuries were evaluated in Dahl S rats and SHR and were scored semiquantitatively. Dynamic autoregulation was efficient and comparable in the low-frequency range (<0.015 Hz) in Dahl R rats, SHR, and Sprague-Dawley rats. The response in Dahl S rats depended strongly on the initiation time of the high salt diet. Autoregulation was preserved during a low salt diet and in rats exposed to a late-onset hypertension of short duration, only partly preserved if the late-onset hypertension was of a longer duration, and abolished in early-onset hypertension. All Dahl S rats on a high salt diet showed severe morphological changes in the kidney. In conclusion, autoregulatory capacity in the kidney of Dahl S rats is gradually impaired when rats are rendered hypertensive with a high salt diet. Renal morphological injuries develop before loss of dynamic autoregulation. Impaired autoregulation appears to be the result, not the cause, of the process that ultimately leads to renal failure in the Dahl S rat.
authors.affiliation: Department of Medical Physiology, The Panum Institute, University of Copenhagen, Denmark. fmk@mfi.ku.dk
authors.forename: F M
authors.initials: FM
authors.lastname: Karlsen
authors.forename: C B
authors.initials: CB
authors.lastname: Andersen
authors.forename: P P
authors.initials: PP
authors.lastname: Leyssac
authors.forename: N H
authors.initials: NH
authors.lastname: Holstein-Rathlou
mesh_terms: D000818:Animals; D001794:Blood Pressure; D004039:Diet, Sodium-Restricted; D004351:Drug Resistance; D006706:Homeostasis; D006973:Hypertension / Q000503:physiopathology; D007668:Kidney / Q000473:pathology*; D008297:Male; D051381:Rats; D011918:Rats, Inbred SHR; D011919:Rats, Inbred Strains; D017207:Rats, Sprague-Dawley; D012079:Renal Circulation; D012965:Sodium Chloride / Q000494:pharmacology
chemical_list: D012965:Sodium Chloride