title: Methodological issues in the use of biological markers in cancer epidemiology: cohort studies.
abstract: In this chapter we summarize the major strengths and weaknesses of cohort studies; consider how these characteristics influence the use of biomarkers in cohort studies; briefly review considerations of statistical power, design and the influence of measurement error in cohort studies; and discuss some of the emerging ethical considerations that relate to the use of biomarkers in prospective studies.
authors.affiliation: Harvard School of Public Health, Department of Epidemiology, Boston, MA 02115, USA.
authors.forename: D J
authors.initials: DJ
authors.lastname: Hunter
mesh_terms: D014408:Biomarkers, Tumor; D015331:Cohort Studies; D015340:Epidemiologic Research Design; D004992:Ethics, Medical; D005260:Female; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000453:epidemiology*; D011446:Prospective Studies
chemical_list: D014408:Biomarkers, Tumor