title: P53 auto-antibodies in the sera of patients with oral squamous cell carcinoma.
abstract: OBJECTIVE
  To investigate the sera of patients with oral squamous cell carcinoma (OSCC) for the existence of p53 auto-antibodies.
  
  
  METHODS
  The sera of thirty-nine OSCC-patients were investigated. All samples were from untreated patients with no history of another neoplastic disease. The sera of nine healthy subjects served as controls.
  
  
  RESULTS
  P53 auto-antibodies were not detected both in all healthy subjects and in 20.6% OSCC-patients with their disease at an advanced stage. We prove that the extinction rates for p53 auto-antibodies in OSCC are very weak in the majority of investigated sera (50%) and are not related to tumour stage.
  
  
  CONCLUSIONS
  It is unlikely that p53 auto-antibodies can serve as a prognostic marker of OSCC.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Eppendorf University Hospital, University of Hamburg, Germany.
authors.forename: R E
authors.initials: RE
authors.lastname: Friedrich
authors.forename: S
authors.initials: S
authors.lastname: Bartel-Friedrich
authors.forename: K
authors.initials: K
authors.lastname: Plambeck
authors.forename: M
authors.initials: M
authors.lastname: Bahlo
authors.forename: R
authors.initials: R
authors.lastname: Klapdor
mesh_terms: D001323:Autoantibodies / Q000097:blood*; D002294:Carcinoma, Squamous Cell / Q000097:blood*; D006801:Humans; D009062:Mouth Neoplasms / Q000097:blood*; D011379:Prognosis; D016159:Tumor Suppressor Protein p53 / Q000276:immunology*
chemical_list: D001323:Autoantibodies; D016159:Tumor Suppressor Protein p53