The role of supraspinal modulation of alpha-2-adrenergic receptors on nociceptive process.
Our findings have shown that both supraspinal activation and blockade of alpha-2-adrenergic receptors change bioelectrical response of studied brain structures on the nociceptive stimulation, among other things by the modulation of hippocampal activity. The mechanism of this effect remains to be established.
Szymbor
B
B
Department of Pharmacology and Toxicology, Military Institute of Hygiene and Epidemiology, Warsaw, Poland.
Kowalczyk
M
M
D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology*; D000818:Animals; D004558:Electric Stimulation; D004567:Electrodes, Implanted; D004594:Electrophysiology; D008297:Male; D009619:Nociceptors / Q000187:drug effects*; D010147:Pain Measurement / Q000187:drug effects; D011817:Rabbits; D018341:Receptors, Adrenergic, alpha-2 / Q000187:drug effects*; D013116:Spinal Cord / Q000187:drug effects*
D000317:Adrenergic alpha-Antagonists; D018341:Receptors, Adrenergic, alpha-2