title: HLA-DQ alleles associate with cutaneous features of onchocerciasis. The Kaduna-London-Manchester Collaboration for Research on Onchocerciasis.
abstract: Onchocerciasis is associated with a spectrum of cutaneous changes, ranging from clinically normal skin to acute and chronic pathology. An important aspect of disease expression may be the level of immune response to parasite antigens, which is likely to be regulated by MHC-encoded molecules. We therefore investigated HLA class I and class II phenotypes in Nigerian residents of an area endemic for onchocerciasis. All study subjects were carefully characterized for parasite load and skin pathology. Individuals with depigmentation had increased frequencies of DQA1*0501 and DQB1*0301 compared with persons with normal skin and high microfilarial load (NSHMF) (Odds Ratios 3.6 (95% CI 1.0 to 13.2) and 3.8 (1.0 to 15.2), respectively). Conversely, individuals with depigmentation had a decreased frequency of DQA1*0101 and Cw6 compared with NSHMF (Odds Ratios 0.2 (0.1 to 0.9) and 0.1 (0.02 to 0.8), respectively). When NSHMF subjects were examined by age, a further decrease in DQA1*0501 frequency and increase in DQA1*0101 frequency were observed in older NSHMF individuals. These results strongly suggest that there is an immunogenetic basis for the spectrum of cutaneous presentations in onchocerciasis and that HLA-DQ molecules are associated with the level of immune response to parasite antigens.
authors.affiliation: Department of Ophthalmology, Ahmadu Bello University Teaching Hospital, Kaduna, Nigeria.
authors.forename: M E
authors.initials: ME
authors.lastname: Murdoch
authors.forename: A
authors.initials: A
authors.lastname: Payton
authors.forename: A
authors.initials: A
authors.lastname: Abiose
authors.forename: W
authors.initials: W
authors.lastname: Thomson
authors.forename: V K
authors.initials: VK
authors.lastname: Panicker
authors.forename: P A
authors.initials: PA
authors.lastname: Dyer
authors.forename: B R
authors.initials: BR
authors.lastname: Jones
authors.forename: R M
authors.initials: RM
authors.lastname: Maizels
authors.forename: W E
authors.initials: WE
authors.lastname: Ollier
mesh_terms: D000293:Adolescent; D000328:Adult; D000483:Alleles; D002648:Child; D005260:Female; D006683:HLA-DQ Antigens / Q000032:analysis / Q000235:genetics*; D059848:HLA-DQ alpha-Chains; D059866:HLA-DQ beta-Chains; D006684:HLA-DR Antigens / Q000032:analysis / Q000235:genetics; D059811:HLA-DRB1 Chains; D006238:Haploidy; D006650:Histocompatibility Testing; D006801:Humans; D008297:Male; D008875:Middle Aged; D009855:Onchocerciasis / Q000276:immunology*; D012871:Skin Diseases / Q000276:immunology* / Q000469:parasitology
chemical_list: D006683:HLA-DQ Antigens; D059848:HLA-DQ alpha-Chains; D059866:HLA-DQ beta-Chains; C069050:HLA-DQA1 antigen; C069051:HLA-DQB1 antigen; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains