CD8+CD28- T cells in vertically HIV-infected children.
To evaluate whether vertical HIV infection interferes with the expression of CD28 on T lymphocytes, 25 HIV-infected children and 29 seroreverted children born to HIV+ mothers were studied. The percentage of CD28- cells among CD8+ T lymphocytes was higher in HIV-infected children than in controls (P < 0.001). In fact, in HIV-infected children, this percentage was elevated from the first year of life, while in healthy seroreverted children, the proportion of CD28- cells among CD8+ cells rose progressively with age (r = 0.49; P = 0.008). In HIV+ children, the CD8+ CD28-, but not CD8+ CD28+ cell proportion was significantly correlated with immunological markers of disease progression, such as CD4+ cell loss (r = -0.65; P < 0.001) and the level of in vitro spontaneous lymphocyte apoptosis (r = 0.53; P = 0.03).
Brugnoni
D
D
Clinical Immunology Service, Spedali Civili and University of Brescia, Italy.
Airo
P
P
Timpano
S
S
Malacarne
F
F
Ugazio
A G
AG
Cattaneo
R
R
Duse
M
M
D000367:Age Factors; D017209:Apoptosis; D018106:CD28 Antigens / Q000276:immunology*; D018791:CD4 Lymphocyte Count; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D015658:HIV Infections / Q000276:immunology* / Q000635:transmission*; D006679:HIV Seropositivity; D006801:Humans; D007223:Infant; D018445:Infectious Disease Transmission, Vertical; D018655:Lymphocyte Count
D018106:CD28 Antigens