Changes in repolarization dynamicity and the assessment of the arrhythmic risk.
At the present time, the assessment of the arrhythmic risk from surface ECG recordings is built on time-domain and frequent-domain analysis of high resolution ECG acquisition together with interlead variability of QT interval duration (QT dispersion). The corresponding raw ECG tracings are obtained in resting conditions. However, the dynamic aspects of the ECG signal is a rapidly evolving matter of interest. In addition to the beat-to-beat oscillations of the ventricular repolarization amplitude (QT alternans), there is growing evidence that the patterns of QT interval shortening with increasing heart rate are linked to susceptibility to ventricular arrhythmias. In this report, we will mainly address the association between QT dynamicity and the risk of developing torsades de pointes.
Maison-Blanche
P
P
Department of Cardiology, Hôpital Lariboisière, Paris, France.
Coumel
P
P
D000889:Anti-Arrhythmia Agents / Q000009:adverse effects; D001145:Arrhythmias, Cardiac / Q000175:diagnosis / Q000503:physiopathology*; D018780:Body Surface Potential Mapping; D004305:Dose-Response Relationship, Drug; D004562:Electrocardiography; D015716:Electrocardiography, Ambulatory; D005080:Exercise Test; D006801:Humans; D008133:Long QT Syndrome / Q000503:physiopathology; D018570:Risk Assessment; D012307:Risk Factors; D016171:Torsades de Pointes / Q000139:chemically induced / Q000503:physiopathology
D000889:Anti-Arrhythmia Agents