title: The xanthine derivatives and cerebral blood flow (CBF) after i.v. or i.c. administration in SHR rats.
abstract: It was shown, that TPH after i.v. administration causes significant decrease of CBF, but IBMX and P-23 had no effects on CBF. After i.c. administration of TPH and P-23 CBF decreased, whereas IBMX i.c. injection had no effect on CBF in SHR rats. These results indicate that direct administration of TPH or P-23 into the cerebral vascular beds causes intensification of TPH activity and reveals the action of P-23. These data suggest, that intracarotid administration of xanthine derivatives can change their cerebrovascular activity.
authors.affiliation: Department of Pharmacology, University of Medical Science in Poznañ, Poland.
authors.forename: R
authors.initials: R
authors.lastname: Forjasz-Grus
authors.forename: T
authors.initials: T
authors.lastname: Bobkiewicz-Kozlowska
mesh_terms: D015056:1-Methyl-3-isobutylxanthine / Q000494:pharmacology; D000818:Animals; D002344:Carotid Body / Q000502:physiology; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D000960:Hypolipidemic Agents / Q000494:pharmacology; D007267:Injections; D007275:Injections, Intravenous; D008297:Male; D010726:Phosphodiesterase Inhibitors / Q000494:pharmacology; D058915:Purinergic P1 Receptor Antagonists; D011727:Pyridinolcarbamate / Q000494:pharmacology; D051381:Rats; D011918:Rats, Inbred SHR; D013806:Theophylline / Q000494:pharmacology; D014970:Xanthines / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D000960:Hypolipidemic Agents; D010726:Phosphodiesterase Inhibitors; D058915:Purinergic P1 Receptor Antagonists; D014970:Xanthines; D011727:Pyridinolcarbamate; D013806:Theophylline; D015056:1-Methyl-3-isobutylxanthine