Echocardiographic assessment of cardiac involvement in systemic AL amyloidosis in relation to whole body amyloid load measured by serum amyloid P component (SAP) clearance.
The severity of cardiac infiltration in AL amyloidosis is unrelated to whole body amyloid load as measured by serum amyloid P (SAP) tracer studies. Radiolabeled SAP and echocardiography permit identification of patients with severe cardiac disease with a low whole body load who may be the best candidates for transplantation.
Clesham
G J
GJ
Department of Medicine, Hammersmith Hospital, London, United Kingdom.
Vigushin
D M
DM
Hawkins
P N
PN
Pepys
M B
MB
Oakley
C M
CM
Nihoyannopoulos
P
P
D000328:Adult; D000368:Aged; D000682:Amyloid / Q000378:metabolism*; D000686:Amyloidosis / Q000503:physiopathology*; D009202:Cardiomyopathies / Q000473:pathology / Q000503:physiopathology*; D015150:Echocardiography, Doppler; D005260:Female; D006352:Heart Ventricles / Q000473:pathology; D006801:Humans; D007457:Iodine Radioisotopes; D008297:Male; D008875:Middle Aged; D000683:Serum Amyloid P-Component / Q000493:pharmacokinetics*; D013997:Time Factors; D016277:Ventricular Function, Left / Q000187:drug effects
D000682:Amyloid; D007457:Iodine Radioisotopes; D000683:Serum Amyloid P-Component; C035222:amyloid protein AL