Varicella vaccination in children after bone marrow transplantation.
Herpes zoster (HZ) is one of the most common complications after bone marrow transplantation (BMT) in children. Apart from treatment with antiviral drugs, effective prevention by active immunization with varicella-zoster virus (VZV) appears to be possible. In this study 15 patients were vaccinated with a live attenuated VZV vaccine (Varilrix) 12-23 months after BMT. The vaccine was well tolerated without adverse reactions. Chickenpox or HZ were not observed for up to 2 years after immunization. Eight out of nine seronegative patients seroconverted and in six virus-specific IgG could still be demonstrated 2 years later. The incidence of VZV diseases in 133 non-immunized children after BMT was 26.3%. Infections usually occurred within 18 months after BMT.
Sauerbrei
A
A
Institute for Antiviral Chemotherapy of the Friedrich Schiller University, Jena, Germany.
Prager
J
J
Hengst
U
U
Zintl
F
F
Wutzler
P
P
D000293:Adolescent; D000914:Antibodies, Viral / Q000097:blood / Q000187:drug effects / Q000276:immunology; D000998:Antiviral Agents / Q000627:therapeutic use; D016026:Bone Marrow Transplantation; D001973:Bromodeoxyuridine / Q000031:analogs & derivatives / Q000627:therapeutic use; D002644:Chickenpox / Q000188:drug therapy / Q000517:prevention & control; D019433:Chickenpox Vaccine / Q000008:administration & dosage* / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D004305:Dose-Response Relationship, Drug; D005500:Follow-Up Studies; D006562:Herpes Zoster / Q000188:drug therapy / Q000517:prevention & control; D006801:Humans; D007108:Immune Tolerance / Q000187:drug effects / Q000276:immunology; D007074:Immunoglobulin G; D012189:Retrospective Studies; D014611:Vaccination
D000914:Antibodies, Viral; D000998:Antiviral Agents; D019433:Chickenpox Vaccine; D007074:Immunoglobulin G; C020235:brivudine; D001973:Bromodeoxyuridine