[Thromboembolic complications in neurosurgical patients].
This study was aimed at the analysis of thromboembolic risk factors in a large and representative group of adult neurosurgical patients. Using an open retrospectively designed mode of evaluation, 3162 inpatients treated in 5 years were investigated. Thromboembolism was diagnosed clinically and confirmed be ultrasound and phlebographic tests. Thromboembolism prophylaxis included subcutaneous injection of low-molecular-weight heparin and supporting physical therapy. In the whole patient population, 2.6% deep venous thromboses and 0.7% fulminant pulmonary embolisms were diagnosed. Risk factors such as malignant disease, ischemic disease of the heart, history of thromboembolism, age over 60 years, varicosis, and immobilisation rendered patients especially prone to thromboembolic events, increasing 2- to 3-fold their respective risk and reaching for some factors the level of statistical significance. Low-molecular-weight heparin application reduced the rate of thromboembolic complications, as compared to the group without heparin prophylaxis. Wound revision because of hematoma formation was necessary in 1.1% of all cases, and heparin did not induce an increase in the rate of wound hematoma formation. We conclude that low-molecular-weight heparin prophylaxis is able to safely reduce the rate of thromboembolic events in neurosurgical patients without producing additional drug-related surgical complications.
Heidecke
V
V
Klinik für Neurochirurgie, Martin-Luther Universität Halle-Wittenberg.
Rainov
N G
NG
Heidecke
K
K
Burkert
W
W
D000328:Adult; D000368:Aged; D002493:Central Nervous System Diseases / Q000601:surgery*; D016543:Central Nervous System Neoplasms / Q000601:surgery*; D003131:Combined Modality Therapy; D005260:Female; D006495:Heparin, Low-Molecular-Weight / Q000008:administration & dosage; D006801:Humans; D008297:Male; D008875:Middle Aged; D026741:Physical Therapy Modalities; D011183:Postoperative Complications / Q000209:etiology* / Q000517:prevention & control; D011655:Pulmonary Embolism / Q000209:etiology / Q000517:prevention & control; D012189:Retrospective Studies; D012307:Risk Factors; D013923:Thromboembolism / Q000209:etiology* / Q000517:prevention & control; D013924:Thrombophlebitis / Q000209:etiology / Q000517:prevention & control
D006495:Heparin, Low-Molecular-Weight