Insulin-like growth factor 1 induces climbing fibre re-innervation of the rat cerebellum.
The effect of insulin-like growth factor 1 (IGF-1) on neonatal plasticity was studied using the rat olivocerebellar projection as a model. Unilateral removal of climbing fibres in the rat before postnatal day 7 induces re-innervation of the deafferented hemi-cerebellum, which does not occur after postnatal day 10. Rats aged 11 or 12 days underwent climbing fibre transection followed by IGF-1 injection into the denervated cerebellar cortex 24 h later. The exogenous IGF-1 induced climbing fibre re-innervation of the denervated hemicerebellum in a pattern similar to that seen in the immature rat. Thus IGF-1 can extend the window of neonatal plasticity of the brain and therefore may be of potential therapeutic use post-trauma.
Sherrard
R M
RM
Neuroscience Laboratory, School of Life Science, Queensland University of Technology, Brisbane, Australia.
D000818:Animals; D000831:Animals, Newborn; D002531:Cerebellum / Q000166:cytology* / Q000187:drug effects; D003714:Denervation; D007267:Injections; D007334:Insulin-Like Growth Factor I / Q000008:administration & dosage / Q000494:pharmacology*; D009410:Nerve Degeneration / Q000473:pathology; D009412:Nerve Fibers / Q000187:drug effects*; D009473:Neuronal Plasticity / Q000187:drug effects; D009847:Olivary Nucleus / Q000166:cytology / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar
D007334:Insulin-Like Growth Factor I