Prophylactic perioperative treatment in a patient with colon carcinoma complicated by polycythemia vera.
A patient with colon carcinoma complicated by polycythemia vera (PV) who underwent a partial colectomy concomitant with prophylactic perioperative treatment resulting in successful outcome is herein described. Seven weeks after the cessation of the latest exacerbation of PV, a partial colectomy was performed. In order to prevent the development of disseminated intravascular coagulation and thrombotic complications, the following perioperative treatment was performed: administration of gabexate mesilate (2,000 mg/day), fresh frozen plasma (300 ml/day), heparin (5,000 IU/day) for 7 days and anti-thrombin-III for 4 days, and a potent antibiotic therapy for 12 days and graded elastic bandages around the bilateral lower extremities for 14 days. As a result, an uneventful postoperative course was achieved. The present case suggests that these treatments are useful in the perioperative management of PV patients.
Yamaguchi
T
T
Department of Surgery, Takayama Red-Cross-Hospital, Japan.
Yokoo
N
N
Kitakado
Y
Y
Shiroko
T
T
Futamura
M
M
Yoneyama
T
T
Mori
S
S
Azuma
H
H
Yonezawa
K
K
Shimizu
K
K
Yoshida
T
T
Tanabashi
S
S
D000230:Adenocarcinoma / Q000150:complications* / Q000601:surgery*; D000368:Aged; D000925:Anticoagulants / Q000627:therapeutic use; D000990:Antithrombin III / Q000627:therapeutic use; D001803:Blood Transfusion; D003082:Colectomy; D003110:Colonic Neoplasms / Q000150:complications* / Q000601:surgery*; D004211:Disseminated Intravascular Coagulation / Q000517:prevention & control; D005260:Female; D016670:Gabexate / Q000627:therapeutic use; D006801:Humans; D010949:Plasma; D011087:Polycythemia Vera / Q000150:complications*; D011183:Postoperative Complications / Q000517:prevention & control*; D013927:Thrombosis / Q000517:prevention & control
D000925:Anticoagulants; D016670:Gabexate; D000990:Antithrombin III