Both plasma and renal endothelin-1 participate in the acute cardiovascular response to exercise.
Plasma endothelin (ET-1) and renal endothelin are two distinct functional systems involved in maintaining blood volume. To investigate whether plasma and renal ET-1 participate in the cardiovascular response to exercise-induced hypovolaemia, we studied changes in plasma and urinary ET-1 in healthy non-professional athletes after 2 h of jogging performed both without and with drinking isotonic fluids. After the run, which caused a 13% plasma volume (PV) reduction, plasma and renal ET-1 (+117% and +118%) increased significantly (all P < 0.01). Fluid loss restitution during the run significantly attenuated either the PV contraction (-1.2%) and plasma and renal ET-1 increase (+2 and +3%). At multiple regression analysis changes in AVP plasma concentration, and not in PRA or PV per se, were significantly related to ET-1 changes both in plasma and urine. The present findings indicate that both plasma and renal ET-1 participate in the cardiovascular response to hypovolaemia induced by long-lasting, dynamic exercise.
Neri Serneri
G G
GG
Clinica Medica e Cardiologia, University of Florence, Italy.
Cecioni
I
I
Migliorini
A
A
Vanni
S
S
Galanti
G
G
Modesti
P A
PA
D000328:Adult; D001810:Blood Volume; D001835:Body Weight; D019332:Endothelin-1 / Q000097:blood* / Q000652:urine*; D006801:Humans; D007552:Isotonic Solutions / Q000008:administration & dosage; D007668:Kidney / Q000737:chemistry*; D008297:Male; D005082:Physical Exertion / Q000502:physiology*; D012044:Regression Analysis; D012083:Renin / Q000097:blood; D014882:Water-Electrolyte Balance
D019332:Endothelin-1; D007552:Isotonic Solutions; D012083:Renin