beta-Amyloid-induced cerebrovascular endothelial dysfunction.
Cerebrovascular effects of beta-amyloid were investigated using bovine mid-cerebral arteries. beta-amyloid-induced endothelial damage was evidenced by increased vasoconstriction, diminished vasodilation and was evident on electron microscopy. The endothelial dysfunction was mediated by reactive oxygen radicals. Vascular damage by beta-amyloid may be an early event in the development of the pathology of Alzheimer's disease.
Thomas
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Department of Psychiatry, College of Medicine, University of South Florida, Tampa 33613, USA.
McLendon
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Sutton
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Thomas
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D016229:Amyloid beta-Peptides / Q000494:pharmacology*; D000818:Animals; D002417:Cattle; D002536:Cerebral Arteries / Q000187:drug effects; D004730:Endothelium, Vascular / Q000187:drug effects*; D066298:In Vitro Techniques; D012701:Serotonin / Q000494:pharmacology; D014661:Vasoconstriction / Q000187:drug effects
D016229:Amyloid beta-Peptides; D012701:Serotonin