Oral administration of a unicellular green algae, Chlorella vulgaris, prevents stress-induced ulcer.
Oral administration of dry powder of Chlorella vulgaris (CVP) showed clear prophylactic effects in water-immersion restraint stress-induced and in cysteamine-induced peptic ulcer models, but not in Shay's rat model. Drugs that enhance the protective factors of ulcer formation are effective in the first two models. CVP may prevent ulcer formation mainly through the "immune-brain-gut" axis and protection of gastric mucosa by its own characteristics.
Tanaka
K
K
Yamada
A
A
Noda
K
K
Shoyama
Y
Y
Kubo
C
C
Nomoto
K
K
D000284:Administration, Oral; D000818:Animals; D002708:Chlorella; D003543:Cysteamine; D005753:Gastric Mucosa / Q000473:pathology / Q000503:physiopathology*; D006632:Histamine; D010946:Plants, Medicinal; D051381:Rats; D012149:Restraint, Physical; D013276:Stomach Ulcer / Q000139:chemically induced / Q000503:physiopathology / Q000517:prevention & control*; D013315:Stress, Psychological
D003543:Cysteamine; D006632:Histamine