title: Effect of alprazolam and ketamine on seizures induced by two different convulsants.
abstract: Effect of two anticonvulsants with different mechanism of action, i.e. alprazolam and ketamine, was tested in two types of seizure activity. The first one was induced by N-(3,5-dimethoxy-4-propoxyphenylethyl)-aziridine, the second one by pentylenetetrazol. While alprazolam alleviated both the minimal as well as major paroxysms, ketamine suppressed only major seizures. These effects are discussed in terms of the both N-methyl-D-aspartate and GABA receptors involvement.
authors.affiliation: Military Medical Academy J. E. Purkynĕ, Hradec Králové.
authors.forename: J
authors.initials: J
authors.lastname: Herink
mesh_terms: D000525:Alprazolam / Q000627:therapeutic use*; D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use*; D001388:Aziridines; D003292:Convulsants; D007649:Ketamine / Q000627:therapeutic use*; D008297:Male; D010433:Pentylenetetrazole; D051381:Rats; D017208:Rats, Wistar; D012640:Seizures / Q000139:chemically induced / Q000188:drug therapy*
chemical_list: D000927:Anticonvulsants; D001388:Aziridines; D003292:Convulsants; C098190:N-((3,5-dimethoxy-4-propoxyphenyl)ethyl)aziridine; D007649:Ketamine; D010433:Pentylenetetrazole; D000525:Alprazolam