Leptin interacts with glucagon-like peptide-1 neurons to reduce food intake and body weight in rodents.
The adipose tissue hormone, leptin, and the neuropeptide glucagon-like peptide-1 (7-36) amide (GLP-1) both reduce food intake and body weight in rodents. Using dual in situ hybridization, long isoform leptin receptor (OB-Rb) was localized to GLP-1 neurons originating in the nucleus of the solitary tract. ICV injection of the specific GLP-1 receptor antagonist, exendin(9-39), at the onset of dark phase, did not affect feeding in saline pre-treated controls, but blocked the reduction in food intake and body weight of leptin pre-treated rats. These findings suggest that GLP-1 neurons are a potential target for leptin in its control of feeding.
Goldstone
A P
AP
Department of Endocrinology and Metabolic Medicine, Imperial College School of Medicine, Hammersmith Hospital, London, UK.
Mercer
J G
JG
Gunn
I
I
Moar
K M
KM
Edwards
C M
CM
Rossi
M
M
Howard
J K
JK
Rasheed
S
S
Turton
M D
MD
Small
C
C
Heath
M M
MM
O'Shea
D
D
Steere
J
J
Meeran
K
K
Ghatei
M A
MA
Hoggard
N
N
Bloom
S R
SR
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism; D015342:DNA Probes; D004435:Eating / Q000187:drug effects; D015870:Gene Expression; D005934:Glucagon / Q000032:analysis / Q000235:genetics / Q000378:metabolism*; D052216:Glucagon-Like Peptide 1; D017403:In Situ Hybridization; D020738:Leptin; D008027:Light; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009474:Neurons / Q000737:chemistry / Q000378:metabolism*; D010446:Peptide Fragments / Q000378:metabolism* / Q000494:pharmacology; D052336:Proglucagon; D011498:Protein Precursors / Q000032:analysis / Q000235:genetics / Q000378:metabolism*; D011506:Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism* / Q000494:pharmacology; D012333:RNA, Messenger / Q000032:analysis; D051381:Rats; D017208:Rats, Wistar; D011956:Receptors, Cell Surface; D054411:Receptors, Leptin; D017552:Solitary Nucleus / Q000166:cytology* / Q000378:metabolism
D002352:Carrier Proteins; D015342:DNA Probes; D020738:Leptin; D010446:Peptide Fragments; D011498:Protein Precursors; D011506:Proteins; D012333:RNA, Messenger; D011956:Receptors, Cell Surface; D054411:Receptors, Leptin; C515447:leptin receptor, mouse; C083773:exendin (9-39); D052336:Proglucagon; D052216:Glucagon-Like Peptide 1; D005934:Glucagon