Quick onset of severe abdominal pain after codeine in an ultrarapid metabolizer of debrisoquine.
The authors describe a 33-year-old woman who experienced severe pain in the epigastrium after codeine intake. This side-effect is consistent with that of morphine. Later, the patient was phenotyped and genotyped as an ultrarapid metabolizer with high capacity to metabolize codeine to morphine.
Dalén
P
P
Department of Medical Laboratory Sciences & Technology, Huddinge University Hospital, Sweden.
Frengell
C
C
Dahl
M L
ML
Sjöqvist
F
F
D015746:Abdominal Pain / Q000139:chemically induced* / Q000378:metabolism; D000328:Adult; D000701:Analgesics, Opioid / Q000009:adverse effects* / Q000378:metabolism; D003061:Codeine / Q000009:adverse effects* / Q000378:metabolism*; D019389:Cytochrome P-450 CYP2D6 / Q000378:metabolism*; D003647:Debrisoquin / Q000378:metabolism; D005260:Female; D006801:Humans
D000701:Analgesics, Opioid; D019389:Cytochrome P-450 CYP2D6; D003061:Codeine; D003647:Debrisoquin