Localization of the candidate tumor suppressor gene ING1 to human chromosome 13q34.
A novel gene ING1 was recently cloned and defined as a candidate tumor suppressor gene. Reduced expression and rearrangements of ING1 are found in several tumor cell lines, ING1 overexpression is associated with cell growth arrest and ING1 suppression promotes neoplastic transformation (1). Using radiation hybrid mapping technique ING1 was assigned to subtelomeric region of the long arm of human chromosome 13 (13q34) which is known to be frequently rearranged in squamous carcinomas of head and neck.
Zeremski
M
M
Department of Genetics, University of Illinois at Chicago 60607, USA.
Horrigan
S K
SK
Grigorian
I A
IA
Westbrook
C A
CA
Gudkov
A V
AV
D000818:Animals; D018797:Cell Cycle Proteins; D002874:Chromosome Mapping; D002882:Chromosomes, Human, Pair 13 / Q000737:chemistry*; D006224:Cricetinae; D004268:DNA-Binding Proteins; D016147:Genes, Tumor Suppressor; D005819:Genetic Markers; D006131:Growth Inhibitors / Q000235:genetics*; D006801:Humans; D006822:Hybrid Cells; D000076023:Inhibitor of Growth Protein 1; D047908:Intracellular Signaling Peptides and Proteins; D051379:Mice; D009687:Nuclear Proteins; D011506:Proteins / Q000235:genetics*; D025521:Tumor Suppressor Proteins
D018797:Cell Cycle Proteins; D004268:DNA-Binding Proteins; D005819:Genetic Markers; D006131:Growth Inhibitors; C501503:ING1 protein, human; C501505:Ing1 protein, mouse; D000076023:Inhibitor of Growth Protein 1; D047908:Intracellular Signaling Peptides and Proteins; D009687:Nuclear Proteins; D011506:Proteins; D025521:Tumor Suppressor Proteins