Effects of midazolam on glycemia and serum lipids in rats.
Midazolam administered ip. in albino rats (each group consisted from 10 animals rendered hyperdyslipidemic by the administration of Triton WR-1339) induced at most doses a significant reduction of glycemia (p < 0.001). However, the reduction of blood glucose level was outside of the dangerous level. Midazolam elicited also very significant decrease of the elevated serum lipids (p < 0.001). The pharmacological analysis of these phenomena by using the peripheral type benzodiazepine (BZD) receptors antagonist PK 11105, the central BZD receptor antagonist flumazenil and the purinergic P1 receptors antagonist aminophylline has shown that the effects on serum lipids were due, very probably to the stimulation of the peripheral type BZD receptors. Aminophylline seems to have the property to block the peripheral type BZD receptors. The effects on blood glucose level were very variable.
Cuparencu
B
B
Department of Pharmacology, University of Oradea, Romania.
Horák
J
J
Horák
A
A
Lenghel
A
A
D000628:Aminophylline / Q000494:pharmacology; D000818:Animals; D014151:Anti-Anxiety Agents / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D001786:Blood Glucose / Q000378:metabolism*; D004347:Drug Interactions; D011345:Fenofibrate / Q000494:pharmacology; D005442:Flumazenil / Q000494:pharmacology; D018757:GABA Modulators / Q000494:pharmacology; D000960:Hypolipidemic Agents / Q000494:pharmacology; D007546:Isoquinolines / Q000494:pharmacology; D008055:Lipids / Q000097:blood*; D008297:Male; D008874:Midazolam / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D010726:Phosphodiesterase Inhibitors / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar
D014151:Anti-Anxiety Agents; D001786:Blood Glucose; D018757:GABA Modulators; D000960:Hypolipidemic Agents; D007546:Isoquinolines; D008055:Lipids; D010726:Phosphodiesterase Inhibitors; D000628:Aminophylline; D005442:Flumazenil; D008874:Midazolam; D011345:Fenofibrate; C037850:PK 11195