title: Effect of salmon-calcitonin on in vitro opioid withdrawal.
abstract: The effect on the in vitro withdrawal sign induced by naloxone in morphine-dependent guinea pig ileum has been analyzed. Salmon calcitonin (s-CT) dose-dependently reduced the force of the contraction induced by naloxone in morphine incubated tissues, but did not modify the contraction induced by administration of acetylcholine or substance P in non-treated tissues. Therefore, the effect of s-CT in morphine incubated tissues may not be attributable to postsynaptic mechanisms, and an inhibitory modulation of the excitatory pathways triggered by naloxone would be suggested. In conclusion, s-CT is able to prevent the withdrawal sign in vitro.
authors.affiliation: Departamento de Farmacología, Facultad de Medicina, Universidad Complutense de Madrid, Spain.
authors.forename: M J
authors.initials: MJ
authors.lastname: Alfaro
authors.forename: B
authors.initials: B
authors.lastname: Fernández
authors.forename: C
authors.initials: C
authors.lastname: Goicoechea
authors.forename: M I
authors.initials: MI
authors.lastname: Martín
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology; D002116:Calcitonin / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004558:Electric Stimulation; D005071:Evoked Potentials / Q000187:drug effects; D006168:Guinea Pigs; D066298:In Vitro Techniques; D009020:Morphine / Q000009:adverse effects*; D009119:Muscle Contraction / Q000187:drug effects; D009270:Naloxone / Q000009:adverse effects*; D013375:Substance Withdrawal Syndrome / Q000188:drug therapy* / Q000503:physiopathology
chemical_list: D009270:Naloxone; D009020:Morphine; D002116:Calcitonin