The protective effect of zinc sulphate pretreatment against duodenal ulcers in the rat.
Exogenously administered zinc compounds have been shown to possess antiulcer activity in the development of gastric lesions. The aim of this study was to investigate the effects of zinc sulphate pretreatment of rats on cysteamine-induced duodenal ulcers and to correlate them with changes in zinc serum and tissue levels. Atomic absorption spectrophotometry was used to determine zinc serum and tissue concentrations in all animal groups. Cysteamine produced marked duodenal ulceration in control animals 24 h after application, with an increase in endogenous zinc tissue concentrations and a marked decrease in serum concentrations. Zinc sulphate (20, 40 or 80 mg kg-1) applied per os one hour prior to cysteamine application inhibited the development of duodenal lesions in a dose-related manner. The application of zinc sulphate in a single intraperitoneal (i.p.) application (80 mg kg-1) did not, however, prevent the formation of duodenal lesions. In order to assess zinc absorption from the gastrointestinal tract, one group of rats received a single oral dose of zinc sulphate (80 mg kg-1) without cysteamine application. The observations of this study seem to indicate that zinc plays an important cytoprotective role in duodenal ulcer disease.
Troskot
B
B
Department of Gastroenterology, Clinical Hospital Sestre Milosrdnice, Medical School, University of Zagreb, Croatia.
Simicevic
V N
VN
Dodig
M
M
Rotkvic
I
I
Ivankovic
D
D
Duvnjak
M
M
D000284:Administration, Oral; D000818:Animals; D003543:Cysteamine; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004381:Duodenal Ulcer / Q000139:chemically induced / Q000517:prevention & control*; D004386:Duodenum / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D005260:Female; D007274:Injections, Intraperitoneal; D007408:Intestinal Absorption / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D013054:Spectrophotometry, Atomic; D015032:Zinc / Q000032:analysis* / Q000097:blood; D019287:Zinc Sulfate / Q000008:administration & dosage* / Q000494:pharmacology
D003543:Cysteamine; D019287:Zinc Sulfate; D015032:Zinc