Th1-type immunity is incompatible with successful pregnancy.
Several years ago, the rather provocative question was raised: is successful pregnancy a T helper 2 (Th2) phenomenon? Implicit in this argument is the corollary that unsuccessful pregnancy is a Th1-type situation. Here, evidence from murine and human pregnancy is presented to show that, since Th1-type cytokines mediate pregnancy loss, a shift towards Th1-type immunity may help resolve 'unexplained' pregnancy failure.
Raghupathy
R
R
Dept. of Microbiology, Faculty of Medicine, Kuwait University, Kuwait. Raj@hscc.kuniv.edu.kw
D000022:Abortion, Spontaneous / Q000276:immunology / Q000517:prevention & control; D000818:Animals; D016207:Cytokines / Q000276:immunology; D005260:Female; D006801:Humans; D007167:Immunotherapy; D051379:Mice; D011247:Pregnancy / Q000276:immunology*; D018417:Th1 Cells / Q000276:immunology*; D018418:Th2 Cells / Q000276:immunology
D016207:Cytokines