title: 3 beta,5 alpha-Dihydroxycholestan-6-one exists in human blood.
abstract: 3 beta,5 alpha-Dihydroxycholestan-6-one was detected in fresh human plasma at the concentration of 14-44 ng/mL. The oxysterol binds specifically to phorbol ester specific binding protein in vitro, and may be an endogenous ligand of the protein.
authors.affiliation: Graduate School of Pharmaceutical Sciences, University of Tokyo, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Yamaguchi
authors.forename: Y
authors.initials: Y
authors.lastname: Endo
authors.forename: M
authors.initials: M
authors.lastname: Shimizu
authors.forename: K
authors.initials: K
authors.lastname: Yamamoto
authors.forename: S
authors.initials: S
authors.lastname: Yamada
authors.forename: K
authors.initials: K
authors.lastname: Shudo
mesh_terms: D000818:Animals; D002417:Cattle; D002470:Cell Survival / Q000502:physiology; D002778:Cholestanones / Q000097:blood*; D006801:Humans; D011485:Protein Binding; D013755:Tetradecanoylphorbol Acetate / Q000097:blood*
chemical_list: D002778:Cholestanones; C082633:yakkasterone; D013755:Tetradecanoylphorbol Acetate