title: Three new pseudodistomins, piperidine alkaloids from the ascidian Pseudodistoma megalarva.
abstract: Bioassay-guided fractionation of the MeOH-CH2Cl2 extract of the Micronesian ascidian Pseudodistoma megalarva yielded three new piperidine alkaloids, pseudodistomins D-F (3-5) and the previously reported pseudodistomins B and C (1 and 2). The structure and stereochemistry of these compounds were established by interpretation of spectral data. Pseudodistomins B-F were found to be active in a cell-based assay for DNA damage induction, but the activity was due to an alternative mechanism.
authors.affiliation: Department of Biomolecular Discovery, SmithKline Beecham Pharmaceuticals, R & D, King of Prussia, Pennsylvania 19406-0939, USA. Alan_J_Freyer@sbphrd.com
authors.forename: A J
authors.initials: AJ
authors.lastname: Freyer
authors.forename: A D
authors.initials: AD
authors.lastname: Patil
authors.forename: L
authors.initials: L
authors.lastname: Killmer
authors.forename: N
authors.initials: N
authors.lastname: Troupe
authors.forename: M
authors.initials: M
authors.lastname: Mentzer
authors.forename: B
authors.initials: B
authors.lastname: Carte
authors.forename: L
authors.initials: L
authors.lastname: Faucette
authors.forename: R K
authors.initials: RK
authors.lastname: Johnson
mesh_terms: D000470:Alkaloids / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D002855:Chromatography, Thin Layer; D004260:DNA Repair / Q000187:drug effects; D004271:DNA, Fungal / Q000096:biosynthesis; D009682:Magnetic Resonance Spectroscopy; D009152:Mutagenicity Tests; D009153:Mutagens / Q000302:isolation & purification* / Q000494:pharmacology; D010880:Piperidines / Q000302:isolation & purification* / Q000494:pharmacology; D014561:Urochordata / Q000737:chemistry*; D015003:Yeasts / Q000187:drug effects / Q000235:genetics
chemical_list: D000470:Alkaloids; D004271:DNA, Fungal; D009153:Mutagens; D010880:Piperidines; C109385:pseudodistomin D; C109386:pseudodistomin E; C109387:pseudodistomin F