Cisplatin-induced renal toxicity: possible reversal by N-acetylcysteine treatment.
Cisplatin administration is frequently associated with renal insufficiency and tubular dysfunction. In this article, a case of massive cisplatin overdose as a result of an accidental substitution for carboplatin is reported. The patient developed oliguric renal failure, hepatotoxicity, ototoxicity, peripheral neuropathy, blindness, and severe myelosuppression. A therapeutic trial with N-acetylcysteine to reverse renal toxicity was attempted. This article reviews the literature on cisplatin nephrotoxicity, with an emphasis on possible mechanisms involved, and suggests therapy for its modification.
Sheikh-Hamad
D
D
Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA.
Timmins
K
K
Jalali
Z
Z
D000111:Acetylcysteine / Q000627:therapeutic use*; D058186:Acute Kidney Injury / Q000139:chemically induced / Q000188:drug therapy / Q000503:physiopathology; D000328:Adult; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000633:toxicity*; D002945:Cisplatin / Q000008:administration & dosage / Q000633:toxicity*; D062787:Drug Overdose; D005260:Female; D016166:Free Radical Scavengers / Q000627:therapeutic use*; D006801:Humans; D007668:Kidney / Q000187:drug effects* / Q000503:physiopathology; D008508:Medication Errors; D013997:Time Factors
D000970:Antineoplastic Agents; D016166:Free Radical Scavengers; D002945:Cisplatin; D000111:Acetylcysteine