A protein particle vaccine containing multiple malaria epitopes.
Ty virus-like particles consist of a single protein species that can be produced in yeast. Recombinant Ty-VLPs carrying a string of up to 15 defined cytotoxic T lymphocyte (CTL) epitopes from Plasmodium species prime protective CTL responses in mice following a single administration without adjuvant. Effective processing of epitopes from the string was demonstrated in vitro and in vivo and was not affected by flanking sequences.
Gilbert
S C
SC
Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, UK.
Plebanski
M
M
Harris
S J
SJ
Allsopp
C E
CE
Thomas
R
R
Layton
G T
GT
Hill
A V
AV
D000595:Amino Acid Sequence; D000818:Animals; D000939:Epitopes / Q000737:chemistry* / Q000276:immunology; D005260:Female; D006801:Humans; D017780:Malaria Vaccines / Q000737:chemistry* / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D008969:Molecular Sequence Data; D010962:Plasmodium berghei / Q000276:immunology; D010963:Plasmodium falciparum / Q000276:immunology*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology
D000939:Epitopes; D017780:Malaria Vaccines