Genetic variation of the apolipoprotein B gene in Korean patients with coronary artery disease.
In view of the clinical importance of apolipoprotein B (apo B) as a major risk factor for coronary artery disease (CAD), we investigated the two polymorphisms (signal peptide and XbaI) of the apo B gene in 235 Korean patients with CAD and in 216 normal controls. The insertion allele (INS) frequency of signal peptide polymorphism was significantly higher in cases than the controls (P<0.05). Signal peptide polymorphism was also associated with levels of plasma cholesterol, triglyceride and low density lipoprotein-cholesterol. However, XbaI polymorphism was not associated with plasma lipid levels. Therefore, our results suggest that signal peptide polymorphism of the apo B gene might be one of the factors in explaining an association in Korean CAD patients.
Hong
S H
SH
Department of Molecular Biology, Center for Cell Differentiation, Seoul National University, Korea.
Lee
C C
CC
Kim
J Q
JQ
D000328:Adult; D000483:Alleles; D001055:Apolipoproteins B / Q000097:blood / Q000235:genetics*; D003327:Coronary Disease / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005796:Genes; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic
D001055:Apolipoproteins B; D008055:Lipids