title: Survey of herpes simplex virus infections of the central nervous system, including acute disseminated encephalomyelitis, in the Kyushu and Okinawa regions of Japan.
abstract: We analysed data from 27 patients with herpes simplex virus (HSV) infections of the central nervous system (CNS) found in a 1990-1992 survey in Kyushu and Okinawa, Japan. Patients ranged in age from one year to 70 years, with peaks seen in the 20s and 50s. Temporal lobe-limbic encephalitis was the most common HSV infection (13 patients), followed by meningitis (5), diffuse encephalitis (4), disseminated encephalomyelitis (ADEM) (3) and brain stem encephalitis (2). Another three patients with non-herpetic, non-paraneoplastic acute limbic encephalitis were presented. Our study indicates that HSV infection can course ADEM, although temporal lobe-limbic encephalitis or meningitis are more common. The early diagnosis of HSV-related ADEM is important because of the efficacy of the timely administration of corticosteroids.
authors.affiliation: First Department (Neurology) of Internal Medicine, Kurume University School of Medicine, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Kaji
authors.forename: T
authors.initials: T
authors.lastname: Kusuhara
authors.forename: M
authors.initials: M
authors.lastname: Ayabe
authors.forename: H
authors.initials: H
authors.lastname: Hino
authors.forename: H
authors.initials: H
authors.lastname: Shoji
authors.forename: T
authors.initials: T
authors.lastname: Nagao
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000914:Antibodies, Viral / Q000097:blood; D001933:Brain Stem / Q000821:virology; D002648:Child; D002675:Child, Preschool; D004673:Encephalomyelitis, Acute Disseminated / Q000175:diagnosis / Q000453:epidemiology* / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006306:Health Surveys; D006561:Herpes Simplex / Q000175:diagnosis / Q000453:epidemiology* / Q000276:immunology; D006801:Humans; D007223:Infant; D007564:Japan / Q000453:epidemiology; D008032:Limbic System / Q000821:virology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D013702:Temporal Lobe / Q000821:virology
chemical_list: D000914:Antibodies, Viral