The stability and conformation of duplex DNA containing the novel anti-HIV drug ADRT.
The anti-HIV drug 4'-azidothymidine (ADRT) has been incorporated into DNA by the phosphoramidite method. The presence of the modified nucleotide was shown to have a minimal effect on duplex conformation and stability by CD spectroscopy and UV melting.
Gibson
N J
NJ
Zenaca Diagnostics, Northwich, England, U.K.
McKellar
C M
CM
Brown
T
T
D019380:Anti-HIV Agents / Q000737:chemistry*; D002942:Circular Dichroism; D004247:DNA / Q000737:chemistry*; D009690:Nucleic Acid Conformation; D013816:Thermodynamics; D015215:Zidovudine / Q000031:analogs & derivatives* / Q000737:chemistry
D019380:Anti-HIV Agents; C072200:4'-azidothymidine; D015215:Zidovudine; D004247:DNA