title: The nucleus basalis (Ch4) in the alcoholic Wernicke-Korsakoff syndrome: reduced cell number in both amnesic and non-amnesic patients.
abstract: BACKGROUND
  The cholinergic nucleus basalis (Ch4) is an exclusive site of neurofibrillary degeneration in alcoholic patients with Wernicke's encephalopathy.
  
  
  OBJECTIVE
  To test the hypothesis that the loss of Ch4 neurons contributes to the memory disorder, Korsakoff's psychosis, commonly seen in Wernicke's encephalopathy.
  
  
  METHODS
  Magnocellular basal forebrain neurons were quantified in alcoholic patients with Wernicke's encephalopathy, both with and without Korsakoff's psychosis, and neurologically asymptomatic alcoholic and non-alcoholic controls. Because amnesic and non-amnesic patients with Wernicke's encephalopathy share common periventricular lesions, both thiamine deficient groups as well as alcoholic patients with no neurological complications were included to determine the lesion specific to memory impairment.
  
  
  RESULTS
  Ch4 cell number did not differ significantly between alcoholic and non-alcoholic controls and there was no correlation between cell number and lifetime alcohol intake. However, Ch4 cell number in all groups was significantly correlated with the volume of its major projection target, the cerebral cortex. Ch4 cell number in the non-amnesic Wernicke's encephalopathy group was significantly below controls (24%), with cell number in patients with Korsakoff's psychosis 21% below controls. There was considerable overlap in cell number between groups. On discriminant analysis, there was significantly greater cell loss in three non-amnesic patients with Wernicke's encephalopathy than in some patients with Korsakoff's psychosis. The nonamnesic patient with the greatest cell loss was impaired on attentional tasks.
  
  
  CONCLUSIONS
  Whereas neurons in the nucleus basalis are at risk in thiamine deficient alcoholic patients, cell loss is minor and does not account for the profound memory disorder.
authors.affiliation: Department of Pathology, The University of Sydney, NSW, Australia.
authors.forename: K M
authors.initials: KM
authors.lastname: Cullen
authors.forename: G M
authors.initials: GM
authors.lastname: Halliday
authors.forename: D
authors.initials: D
authors.lastname: Caine
authors.forename: J J
authors.initials: JJ
authors.lastname: Kril
mesh_terms: D000328:Adult; D000368:Aged; D000425:Alcohol Amnestic Disorder / Q000150:complications* / Q000473:pathology* / Q000523:psychology; D000437:Alcoholism / Q000150:complications*; D000647:Amnesia / Q000209:etiology*; D001921:Brain / Q000473:pathology*; D002799:Cholinergic Fibers / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009410:Nerve Degeneration; D012044:Regression Analysis; D013832:Thiamine Deficiency / Q000209:etiology; D014899:Wernicke Encephalopathy / Q000150:complications* / Q000473:pathology*