Association of apolipoprotein allele epsilon 2 with psoriasis vulgaris in Japanese population.
We studied phenotypic variations of apolipoprotein E (apoE) and the corresponding allele frequencies in 100 Japanese patients with psoriasis vulgaris (PV). The phenotypes of apoE were examined using analytical isoelectric focusing followed by immunoblotting with goat anti-apoE antibody and alkaline phosphatase-conjugated rabbit antigoat IgG. The phenotypic frequency of apoE3/2 in PV was significantly higher than in healthy controls, and this elevation was associated with an increased frequency of the epsilon 2 allele. Therefore, it is suggested that the apoE molecule plays an important role in the development of PV.
Furumoto
H
H
Department of Dermatology, Yamaguchi University School of Medicine, Japan.
Nakamura
K
K
Imamura
T
T
Hamamoto
Y
Y
Shimizu
T
T
Muto
M
M
Asagami
C
C
D000293:Adolescent; D000328:Adult; D000368:Aged; D000483:Alleles; D001057:Apolipoproteins E / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005787:Gene Frequency; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D011565:Psoriasis / Q000235:genetics*
D001057:Apolipoproteins E