Functional activation during an auditory comprehension task in patients with temporal lobe lesions.
Functional magnetic resonance imaging (fMRI) was used to map regional brain activation during an auditory comprehension task in two normal controls and two patients with left temporal lobe lesions. Activity in the superior temporal and angular gyrus regions was detected in all normal subjects. In the patients, the spatial distribution of activation ipsilateral to the lesions differed from the pattern observed in contralateral cortex or in control subjects. These studies highlight the potential of fMRI for mapping abnormal functional anatomy in the human brain.
Alsop
D C
DC
Department of Radiology, University of Pennsylvania Medical Center, Philadelphia 19104, USA.
Detre
J A
JA
D'Esposito
M
M
Howard
R S
RS
Maldjian
J A
JA
Grossman
M
M
Listerud
J
J
Flamm
E S
ES
Judy
K D
KD
Atlas
S W
SW
D000328:Adult; D000849:Anomia / Q000503:physiopathology; D001288:Attention / Q000502:physiology*; D001925:Brain Damage, Chronic / Q000503:physiopathology*; D001931:Brain Mapping; D004833:Epilepsy, Temporal Lobe / Q000503:physiopathology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D009483:Neuropsychological Tests; D013067:Speech Perception / Q000502:physiology*; D013702:Temporal Lobe / Q000503:physiopathology*