title: Does fasting plasma insulin increase by age in the general elderly population?
abstract: The aim of this study was to examine the association of fasting plasma insulin with age. Insulin levels are influenced by obesity, physical inactivity, and medications, e.g., thiazide diuretics and beta adrenergic blockers. Further, comorbidity and pre-terminal conditions may confound the age-association of insulin. 1197 random subjects from four birth cohorts of the general aged population in southern Finland were examined, and followed for five years. Insulin levels at baseline tended to increase in men to the age of 75 years (mean 15.1 mU/L, SE 2.18), and in women to the age of 80 years (mean 15.9 mU/L, SE 1.14). The same association was seen among survivors in a five-year follow-up. These associations remained significant after controlling for obesity, physical inactivity and hyperinsulinogenic medications.
authors.affiliation: Department of Medicine, University of Helsinki, Finland.
authors.forename: O
authors.initials: O
authors.lastname: Lindberg
authors.forename: R S
authors.initials: RS
authors.lastname: Tilvis
authors.forename: T E
authors.initials: TE
authors.lastname: Strandberg
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000097:blood*; D002318:Cardiovascular Diseases / Q000209:etiology; D015331:Cohort Studies; D003924:Diabetes Mellitus, Type 2 / Q000209:etiology; D005215:Fasting / Q000097:blood; D005260:Female; D005387:Finland; D005500:Follow-Up Studies; D006801:Humans; D007328:Insulin / Q000097:blood*; D007333:Insulin Resistance; D008297:Male; D012307:Risk Factors
chemical_list: D007328:Insulin