title: Misoprostol (cytotec) in the treatment of peripheral ischaemic disease.
abstract: The stable prostacyclin analogue-iloprost and prostaglandin E1 (Alprostadil) showed a beneficial effect on activated platelets and leukocytes, and thrombocyte and leukocyte vessel interaction and damaged endothelium, improving microvascular perfusion and were useful in treatment of patients with peripheral arterial disease. The 4 weeks therapy with misoprostol caused a clinical improvement in all 14 patients and resulted in vasorelaxation and showed antiplatelet and fibrinolytic effects.
authors.forename: A
authors.initials: A
authors.lastname: Goszcz
authors.forename: L
authors.initials: L
authors.lastname: Grodzinska
authors.forename: E
authors.initials: E
authors.lastname: Kostka-Trebka
authors.forename: K
authors.initials: K
authors.lastname: Bieron
authors.forename: M
authors.initials: M
authors.lastname: Slawinski
authors.forename: R
authors.initials: R
authors.lastname: Jachym
mesh_terms: D006801:Humans; D016595:Misoprostol / Q000627:therapeutic use*; D016491:Peripheral Vascular Diseases / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D012039:Regional Blood Flow / Q000187:drug effects / Q000502:physiology
chemical_list: D016595:Misoprostol