title: Prognostic value of nuclear morphometry in feline mammary carcinomas.
abstract: This study of 30 cats with mammary carcinoma was designed to investigate the relationship between (1) six nuclear morphometric parameters (mean nuclear profile area [MNA], standard deviation of MNA [SDa], coefficient of variation of MNA [CVa], nuclear form factor (p2/4 pi area) [FF], standard deviation of FF [SDf], and coefficient of variation of FF [CVf]) assessed by image analysis, and (2) survival for > 1 year or < 1 year after surgical removal of the tumour. Only the SDf and the CVf appeared to be related to survival. Cats that died within 1 year had an SDf or CVf (or both) higher than the corresponding mean values (SDft and CVft) for all 30 cats; but only four of 16 cases (25%) with a SDf lower than SDft and five of 17 cases (29.4%) with a CVf lower than CVft died within 1 year. The authors conclude that SDf and CVf represent reliable prognostic parameters in feline mammary carcinomas.
authors.affiliation: Dipartimento di Patologia, Facoltà di Medicina Veterinaria, Università di Napoli Federico II, Italy.
authors.forename: G
authors.initials: G
authors.lastname: De Vico
authors.forename: P
authors.initials: P
authors.lastname: Maiolino
mesh_terms: D000230:Adenocarcinoma / Q000401:mortality / Q000473:pathology / Q000662:veterinary*; D000818:Animals; D002277:Carcinoma / Q000401:mortality / Q000473:pathology / Q000662:veterinary*; D002415:Cats; D002467:Cell Nucleus / Q000473:pathology*; D015674:Mammary Neoplasms, Animal / Q000401:mortality / Q000473:pathology*; D011237:Predictive Value of Tests; D011379:Prognosis; D015996:Survival Rate