title: [Hepatic veno-occlusive disease associated to the use of azathioprine in a renal transplant recipient].
abstract: We report a 30 years old male, recipient of a kidney allograft and treated with azathioprine, who eighteen days after transplantation had a clinically asymptomatic elevation of total bilirubin and alkaline phosphatases. Nineteen months later, he presented with mild ascites, with a total bilirubin of 3.5 mg/dl, alkaline phosphatases of 308 U/L (normal < 170 U/L) and a prothrombin time at 55% of control. A liver biopsy showed sinusoidal and perivenular fibrosis without inflammation, compatible with chronic venous obstruction. Hepatic veno-occlusive disease is an infrequent complication of azathioprine use.
authors.affiliation: Departamento de Medicina Interna, Hospital Clínico Universidad de Chile.
authors.forename: K
authors.initials: K
authors.lastname: Hola
authors.forename: J
authors.initials: J
authors.lastname: Brahm
authors.forename: M
authors.initials: M
authors.lastname: Alvo
authors.forename: A
authors.initials: A
authors.lastname: Cotera
authors.forename: W
authors.initials: W
authors.lastname: Passalacqua
authors.forename: G
authors.initials: G
authors.lastname: Smok
mesh_terms: D000328:Adult; D001379:Azathioprine / Q000009:adverse effects* / Q000627:therapeutic use; D006504:Hepatic Veno-Occlusive Disease / Q000139:chemically induced* / Q000175:diagnosis; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D007676:Kidney Failure, Chronic / Q000601:surgery*; D016030:Kidney Transplantation; D008297:Male
chemical_list: D007166:Immunosuppressive Agents; D001379:Azathioprine