Baculoviruses as expression vectors.
Recent advances in baculovirus expression vector technology include improvements to methods for the selection of recombinant viruses and further developments in virion display vectors. It is now also possible to modify the host cell glycosylation pathway to alter the structure of glycans added to the recombinant polypeptide. Baculovirus vectors also continue to be modified to facilitate gene expression in mammalian cells.
Possee
R D
RD
NERC Institute of Virology and Environmental Microbiology, Oxford, UK. possee@molbiol.ox.ac.uk
D000818:Animals; D016367:Baculoviridae; D001709:Biotechnology / Q000379:methods; D002460:Cell Line; D017930:Genes, Reporter; D005822:Genetic Vectors; D006023:Glycoproteins / Q000096:biosynthesis*; D006801:Humans; D007313:Insecta; D011499:Protein Processing, Post-Translational; D011994:Recombinant Proteins / Q000096:biosynthesis*; D014162:Transfection / Q000379:methods*; D014771:Virion
D006023:Glycoproteins; D011994:Recombinant Proteins