Chemical structure of lipid A from Helicobacter pylori strain 206-1 lipopolysaccharide.
The chemical structure of a novel lipid A, which was obtained as a major component from lipopolysaccharide of Helicobacter pylori strain 206-1, was determined to be a glucosamine beta(1-6) disaccharide 1-(2-aminoethyl)phosphate acylated by (R)-3-hydroxyoctadecanoic acid and (R)-3-(octadecanoyloxy)octadecanoic acid at the 2- and 2'-position, respectively. The absence of a phosphoryl group at the 4'-position and fatty acyl groups at the 3- and 3'-position, and the stoichiometric presence of 2-aminoethyl phosphate at the 1-position are unique features, distinguishing it from the lipid A of enterobacteria.
Suda
Y
Y
Department of Chemistry, Graduate School of Science, Osaka University, Toyonaka. ysuda@chem.sci.osaka-u.ac.jp
Ogawa
T
T
Kashihara
W
W
Oikawa
M
M
Shimoyama
T
T
Hayashi
T
T
Tamura
T
T
Kusumoto
S
S
D002240:Carbohydrate Sequence; D016480:Helicobacter pylori / Q000737:chemistry*; D008050:Lipid A / Q000737:chemistry*; D008070:Lipopolysaccharides / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008969:Molecular Sequence Data; D015394:Molecular Structure
D008050:Lipid A; D008070:Lipopolysaccharides