title: Fatal hepatic necrosis after isoflurane anaesthesia.
abstract: Several halogenated anaesthetic agents have been associated with hepatotoxicity. We report a case of fulminant, fatal hepatic necrosis after uneventful isoflurane anaesthesia in a patient without previous liver disease, who may have been sensitised by previous exposure to enflurane. Although no anti-trifluoroacetyl antibodies could be detected in the patient's serum, isoflurane hepatotoxicity seems very likely to be the reason for fulminant hepatic failure in this patient.
authors.affiliation: Department of Surgery, University of Heidelberg, Germany.
authors.forename: J
authors.initials: J
authors.lastname: Weitz
authors.forename: P
authors.initials: P
authors.lastname: Kienle
authors.forename: H
authors.initials: H
authors.lastname: Böhrer
authors.forename: W
authors.initials: W
authors.lastname: Hofmann
authors.forename: L
authors.initials: L
authors.lastname: Theilmann
authors.forename: G
authors.initials: G
authors.lastname: Otto
mesh_terms: D000328:Adult; D018685:Anesthetics, Inhalation / Q000009:adverse effects*; D017809:Fatal Outcome; D005260:Female; D006501:Hepatic Encephalopathy / Q000139:chemically induced*; D006801:Humans; D007530:Isoflurane / Q000009:adverse effects*; D008099:Liver / Q000473:pathology*; D009336:Necrosis
chemical_list: D018685:Anesthetics, Inhalation; D007530:Isoflurane