title: Second-trimester membrane rupture. Abortion induced with prostaglandin E2 after oxytocin failure.
abstract: OBJECTIVE
  To test an effective method of terminating second-trimester pregnancy with ruptured membranes in women who fail to abort from an oxytocin infusion.
  
  
  METHODS
  Five patients with rupture of membranes during the second trimester of pregnancy and failed to abort using the traditional method of intravenous oxytocin infusion were treated with intrauterine instillation of prostaglandin E2 (PGE2) solution through a double-balloon device.
  
  
  RESULTS
  All five patients aborted within 8.8 +/- 4.5 hours from the beginning of PGE2 instillation. No major complications occurred. The only side effect was short-duration pyrexia (less than 48 hours).
  
  
  CONCLUSIONS
  Use of the double-balloon device and intrauterine instillation of PGE2 was effective for termination of pregnancy in patients with rupture of membranes who do not respond to oxytocin.
authors.affiliation: Department of Obstetrics and Gynecology, Carmel Medical Center/Technion School of Medicine, Haifa, Israel.
authors.forename: J
authors.initials: J
authors.lastname: Atad
authors.forename: M
authors.initials: M
authors.lastname: Hallak
authors.forename: O
authors.initials: O
authors.lastname: Fruchter
authors.forename: J
authors.initials: J
authors.lastname: Borenstein
authors.forename: H
authors.initials: H
authors.lastname: Abramovici
mesh_terms: D000019:Abortifacient Agents; D000028:Abortion, Induced / Q000379:methods*; D000328:Adult; D015232:Dinoprostone / Q000008:administration & dosage*; D005260:Female; D005322:Premature Rupture of Fetal Membranes; D005865:Gestational Age; D006801:Humans; D010121:Oxytocin / Q000008:administration & dosage; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D017211:Treatment Failure; D014599:Uterus / Q000187:drug effects*
chemical_list: D000019:Abortifacient Agents; D010121:Oxytocin; D015232:Dinoprostone