Effects of postoperative peritoneal lavage on pharmacokinetics of gentamicin in horses after celiotomy.
OBJECTIVE
To evaluate the effect of peritoneal lavage on pharmacokinetics of gentamicin sulfate in healthy horses after experimental celiotomy.


METHODS
13 clinically normal horses.


METHODS
Horses were randomly assigned to control or experimental groups. All horses received gentamicin (6.6 mg/kg of body weight, IV, q 24 h) before surgery, underwent experimental abdominal surgery, and had abdominal drains placed percutaneously. Horses of the experimental group received postoperative peritoneal lavage; horses of the control group did not receive peritoneal lavage. The day after surgery, 24 hours after the preoperative dose of gentamicin, a second dose of gentamicin was administered. Three and 15 hours after this second dose of gentamicin, horses of the experimental group received peritoneal lavage. Venous blood was obtained, for determination of concentration of gentamicin, immediately before and at specified intervals during the 24-hour period after the second dose of gentamicin.


RESULTS
There were no differences in any of the pharmacokinetic values of gentamicin between horses of the control and experimental groups.


CONCLUSIONS
Peritoneal lavage had no effect on pharmacokinetics of gentamicin in healthy horses after abdominal surgery, in which localized nonseptic peritonitis was induced.


CONCLUSIONS
Peritoneal lavage in horses with localized nonseptic peritonitis or for the prevention of intra-abdominal adhesions should not necessitate alteration of the dosage of gentamicin to maintain predictable serum concentrations.
Easter
J L
JL
Department of Large Animal Medicine and Surgery, College of Veterinary Medicine, Texas A&M University, College Station 77843, USA.
Hague
B A
BA
Brumbaugh
G W
GW
Nguyen
J
J
Chaffin
M K
MK
Honnas
C M
CM
Kemper
D L
DL
D000005:Abdomen / Q000601:surgery*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000032:analysis / Q000097:blood / Q000493:pharmacokinetics*; D001202:Ascitic Fluid / Q000737:chemistry / Q000662:veterinary; D005839:Gentamicins / Q000032:analysis / Q000097:blood / Q000493:pharmacokinetics*; D006734:Horse Diseases / Q000517:prevention & control; D006736:Horses / Q000097:blood / Q000378:metabolism* / Q000601:surgery*; D010533:Peritoneal Lavage / Q000379:methods / Q000662:veterinary*; D011182:Postoperative Care / Q000662:veterinary; D011184:Postoperative Period; D013997:Time Factors; D000267:Tissue Adhesions / Q000517:prevention & control / Q000662:veterinary
D000900:Anti-Bacterial Agents; D005839:Gentamicins