title: Cell communities and robustness in development.
abstract: The robustness of patterning events in development is a key feature that must be accounted for in proposed models of these events. When considering explicitly cellular systems, robustness can be exhibited at different levels of organization. Consideration of two widespread patterning mechanisms suggests that robustness at the level of cell communities can result from variable development at the level of individual cells; models of these mechanisms show how interactions between participating cells guarantee community-level robustness. Cooperative interactions enhance homogeneity within communities of like cells and the sharpness of boundaries between communities of distinct cells, while competitive interactions amplify small inhomogeneities within communities of initially equivalent cells, resulting in fine-grained patterns of cell specialization.
authors.affiliation: Centre for Mathematical Biology, University of Oxford, U.K. nmonk@maths.ox.ac.uk
authors.forename: N A
authors.initials: NA
authors.lastname: Monk
mesh_terms: D000818:Animals; D002450:Cell Communication; D005314:Embryonic and Fetal Development; D005246:Feedback; D008433:Mathematics; D008954:Models, Biological