Ribavirin therapy for adenovirus pneumonia in an AIDS patient.
We report the effectiveness of ribavirin in an AIDS patient with multinodular pneumonia due to adenovirus. A 38-year-old AIDS patient who experienced multiple opportunistic infections and whose CD4 lymphocyte count was 5/mm3 developed bilateral nodular lung opacities. Lung surgical biopsy yielded necrotizing pneumonitis with characteristic nuclear inclusions and positive immunocytology with adenovirus antibodies. Marked clinical and radiological improvement was obtained after intravenous then oral ribavirin. Ribavirin was discontinued after 40 d because of anemia. Relapse of pneumonia with respiratory distress led to death 8 mo later. This observation illustrates a rarely reported pulmonary opportunistic infection in AIDS and the potential value of ribavirin therapy for adenovirus pneumonia.
Maslo
C
C
Service des Maladies Infectieuses et Tropicales, Hôpital Rothschild, Paris, France.
Girard
P M
PM
Urban
T
T
Guessant
S
S
Rozenbaum
W
W
D017088:AIDS-Related Opportunistic Infections / Q000175:diagnosis / Q000188:drug therapy* / Q000276:immunology; D000258:Adenovirus Infections, Human / Q000175:diagnosis / Q000188:drug therapy* / Q000276:immunology; D000260:Adenoviruses, Human / Q000276:immunology; D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis; D000998:Antiviral Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001706:Biopsy; D018791:CD4 Lymphocyte Count; D017809:Fatal Outcome; D005500:Follow-Up Studies; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D011024:Pneumonia, Viral / Q000175:diagnosis / Q000188:drug therapy* / Q000276:immunology; D012008:Recurrence; D012254:Ribavirin / Q000008:administration & dosage / Q000627:therapeutic use*; D014057:Tomography, X-Ray Computed
D000914:Antibodies, Viral; D000998:Antiviral Agents; D012254:Ribavirin