DNA typing of the HLA-A, -B and -C genes: possible MHC class I haplotypes in the northeastern-Thais.
The phenotype and gene frequencies of HLA class I were studied in the Northeastern Thai population. Blood samples were collected from 100 unrelated healthy northeastern-Thais. HLA-A, -B and -Cw alleles were determined using the polymerase chain reaction- amplification refractory mutation system (PCR-ARMS). 12 HLA-A, 20 HLA-B and 14 HLA-Cw alleles were found. Linkage disequilibrium analysis indicated the existence of 7 HLA-A-B and 19 HLA-B-Cw haplotypes. A*0207-Cw*01-B*4601 was the most common possible haplotype in this population. These results provide regional basic information for further studies in anthropology, organ transplantation and MHC disease associations in the northeastern-Thais.
Romphruk
A
A
Blood Transfusion Centre, Faculty of Medicine, Khon Kaen University, Thailand.
Leelayuwat
C
C
Barusrux
S
S
Puapairoj
C
C
Romphruk
A
A
Urwijitaroon
Y
Y
D000483:Alleles; D016009:Chi-Square Distribution; D005006:Ethnicity / Q000235:genetics*; D005787:Gene Frequency; D015234:HLA-A Antigens / Q000235:genetics*; D015235:HLA-B Antigens / Q000235:genetics*; D015236:HLA-C Antigens / Q000235:genetics*; D006239:Haplotypes; D006720:Homozygote; D006801:Humans; D010641:Phenotype; D016133:Polymerase Chain Reaction / Q000379:methods; D011110:Polymorphism, Genetic; D013785:Thailand
D015234:HLA-A Antigens; D015235:HLA-B Antigens; D015236:HLA-C Antigens