title: 99Tcm-MDP scintigraphy in high-voltage electrical burn patients.
abstract: In high-voltage electrical burn injuries (> 1000 V), it is difficult to identify the site and extent of non-viable deep tissue damage for debridement to avoid further tissue injury from wound infection and the risk of sepsis. This prospective study was designed to evaluate the usefulness of 99Tcm-methylene di-phosphonate (99Tcm-MDP) scintigraphy in detecting the extent of tissue injury and determining the level of amputation required for electrical burn patients. Over a 5 year period, 33 high-voltage electrical burn patients were studied. Blood flow and blood pool studies revealed absent perfusion in 37 limbs, all of which eventually were amputated. In addition to a routine three-phase bone scan, images were obtained at 30-60 min (early images) to evaluate whether soft tissue injury could be detected better at that time. For comparison of the detection rate from the early images and bone (delayed) images, 164 corresponding spot views of both images were reviewed. Eighty-three and 125 tissue necrotic lesions were demonstrated by the early images and bone images respectively. All of the 83 lesions found by the early images were more clearly identified by the bone images. All but one of the 125 lesions underwent surgical debridement or amputation. We concluded that the blood flow and blood pool images correlated well with the level of amputation required. The site and extent of tissue necrotic lesions can be clearly identified on 99Tcm-MDP bone scans. Because the early images were less sensitive in detecting tissue necrosis, we suggest that early imaging is not necessary.
authors.affiliation: Department of Nuclear Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan, Republic of China.
authors.forename: P F
authors.initials: PF
authors.lastname: Kao
authors.forename: K Y
authors.initials: KY
authors.lastname: Tzen
authors.forename: L Y
authors.initials: LY
authors.lastname: Chang
authors.forename: D L
authors.initials: DL
authors.lastname: You
authors.forename: J Y
authors.initials: JY
authors.lastname: Yang
mesh_terms: D000293:Adolescent; D000328:Adult; D000671:Amputation, Surgical; D001842:Bone and Bones / Q000000981:diagnostic imaging; D002058:Burns, Electric / Q000000981:diagnostic imaging* / Q000503:physiopathology / Q000601:surgery; D002648:Child; D003646:Debridement; D005121:Extremities / Q000098:blood supply / Q000000981:diagnostic imaging / Q000293:injuries; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009336:Necrosis; D011446:Prospective Studies; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D012039:Regional Blood Flow; D013669:Technetium Tc 99m Medronate
chemical_list: D019275:Radiopharmaceuticals; D013669:Technetium Tc 99m Medronate