Synthesis of lactosyl phosphate diester derivatives of nucleosides.
Derivatives of the lactosyl phosphate diester and the lactosyl thiophosphate diester of 1-(beta-D-arabinofuranosyl)cytosine (Ara-C) and 9-(beta-D-arabinofuranosyl)adenine (Ara-A) were synthesized by condensation of 3-hydroxypropyl lactoside and a protected Ara-C or Ara-A via H-phosphonate methodology and phosphoramidite methodology, respectively.
Cai
T W
TW
National Research Laboratories of Natural and Biomimetic Drugs, Beijing Medical University, China.
Min
J M
JM
Zhang
L H
LH
D000818:Animals; D002240:Carbohydrate Sequence; D003561:Cytarabine / Q000737:chemistry*; D004952:Esters; D007275:Injections, Intravenous; D007668:Kidney / Q000737:chemistry; D007785:Lactose / Q000737:chemistry*; D008099:Liver / Q000737:chemistry; D051379:Mice; D008969:Molecular Sequence Data; D009928:Organ Specificity; D010710:Phosphates / Q000737:chemistry*; D014740:Vidarabine / Q000737:chemistry*
D004952:Esters; D010710:Phosphates; D003561:Cytarabine; D014740:Vidarabine; D007785:Lactose