title: [How is hemolytic-uremic syndrome in childhood acquired in Switzerland?].
abstract: Intestinal infections with shigatoxin-producing Escherichia coli or Shigella dysenteriae type I play a major role in the pathogenesis of the hemolytic-uremic syndrome in childhood. Escherichia coli has been repeatedly detected in the intestines of healthy cattle. Twenty-seven children with hemolytic-uremic syndrome were treated at our hospital between June 1990 and March 1997. Factors indicating a possible previous contact with bovine intestinal content were found in 18 out of the 27 patients: parents stockbreeders (n = 7), recent visit to a cowshed or contact with cowdung or manure (n = 5), residence in a rural cattle-breeding area (n = 5), or consumption of raw milk (n = 1). The factors mentioned were found in 5 out of 27 control patients (p < 0.01). Two children experienced hemolytic-uremic syndrome after a stay respectively in Egypt and Tunisia. Our results indicate an important source for acquisition of hemolytic-uremic syndrome in childhood. Observing simple hygienic rules such as washing of hands and pasteurization of milk is likely to have a positive influence on the incidence of this illness. There are also grounds to consider adding the hemolytic-uremic syndrome to the list of travel-related diseases.
authors.affiliation: Medizinische Universitätskinderklinik, Inselspital, Bern.
authors.forename: K H
authors.initials: KH
authors.lastname: Kernland
authors.forename: R
authors.initials: R
authors.lastname: Laux-End
authors.forename: A C
authors.initials: AC
authors.lastname: Truttmann
authors.forename: D
authors.initials: D
authors.lastname: Reymond
authors.forename: M G
authors.initials: MG
authors.lastname: Bianchetti
mesh_terms: D000818:Animals; D002417:Cattle; D002648:Child; D002675:Child, Preschool; D004405:Dysentery, Bacillary / Q000150:complications / Q000635:transmission; D004927:Escherichia coli Infections / Q000150:complications / Q000635:transmission; D005260:Female; D005759:Gastroenteritis / Q000150:complications / Q000209:etiology; D005766:Gastrointestinal Contents / Q000382:microbiology; D006463:Hemolytic-Uremic Syndrome / Q000209:etiology* / Q000517:prevention & control; D006801:Humans; D007223:Infant; D008297:Male; D012307:Risk Factors; D012762:Shigella dysenteriae; D014195:Travel