title: Aluminum site structure in serum transferrin and lactoferrin revealed by synchrotron radiation X-ray spectroscopy.
abstract: The Al site structure of serum transferrin and lactoferrin is investigated using X-ray absorption near edge structure (XANES) spectroscopy. Al K-edge spectra in the mono- and dialuminum forms of the proteins have been recorded for the first time. Our results show that the aluminium ion is hexa-coordinated in an octahedral-like symmetry and that the monoaluminum form, where only the C-terminal binding site is saturated, has an increased structural distortion around the metal site.
authors.affiliation: Dipartimento di fisica and INFM, Universita' la Sapienza, Roma, Italy. congiu@axcasp.caspur.it
authors.forename: A
authors.initials: A
authors.lastname: Congiu-Castellano
authors.forename: F
authors.initials: F
authors.lastname: Boffi
authors.forename: S
authors.initials: S
authors.lastname: Della Longa
authors.forename: A
authors.initials: A
authors.lastname: Giovannelli
authors.forename: M
authors.initials: M
authors.lastname: Girasole
authors.forename: F
authors.initials: F
authors.lastname: Natali
authors.forename: M
authors.initials: M
authors.lastname: Pompa
authors.forename: A
authors.initials: A
authors.lastname: Soldatov
authors.forename: A
authors.initials: A
authors.lastname: Bianconi
mesh_terms: D000535:Aluminum / Q000032:analysis* / Q000737:chemistry; D001665:Binding Sites; D007781:Lactoferrin / Q000737:chemistry*; D013052:Spectrometry, X-Ray Emission; D014168:Transferrin / Q000737:chemistry*
chemical_list: D014168:Transferrin; D000535:Aluminum; D007781:Lactoferrin