Inhibition of virus-induced age-dependent poliomyelitis by interferon-gamma.
Age-dependent poliomyelitis (ADPM) is a neuroparolytic disease which results from combined infection of susceptible mice with lactate dehydrogenase-elevating virus (LDV) and murine leukemia virus (MuLV). The present study examined the effects of interferon-gamma (IFN-gamma) treatment on the incidence of ADPM, replication of LDV and MuLV and anti-LDV immunity. IFN-gamma treatment of ADPM-susceptible C58/M mice protected them from paralytic disease, but had no detectable effect on the IgG anti-LDV response or LDV viremia. IFN-gamma-mediated protection from ADPM correlated with reduced expression of LDV RNA, but not MuLV RNA, in the spinal cords of C58/M mice. These results confirm that spinal cord LDV replication is the determinant of ADPM and demonstrate that cytokine-mediated inhibition of LDV replication in the central nervous system prevents neuroparalytic disease.
Cafruny
W A
WA
Department of Microbiology, University of South Dakota School of Medicine, Vermillion, USA. bcafruny@sundance.usd.edu
Haven
T R
TR
Lawson
S R
SR
Wong
G H
GH
Rowland
R R
RR
D000375:Aging / Q000473:pathology*; D000818:Animals; D000917:Antibody Formation; D020022:Genetic Predisposition to Disease; D007074:Immunoglobulin G / Q000096:biosynthesis; D007371:Interferon-gamma / Q000494:pharmacology*; D007772:Lactate dehydrogenase-elevating virus / Q000187:drug effects* / Q000276:immunology / Q000302:isolation & purification; D009052:Leukemia Virus, Murine / Q000187:drug effects*; D051379:Mice; D008817:Mice, Mutant Strains; D011051:Poliomyelitis / Q000517:prevention & control*; D012367:RNA, Viral / Q000235:genetics; D013116:Spinal Cord / Q000821:virology
D007074:Immunoglobulin G; D012367:RNA, Viral; D007371:Interferon-gamma