Selective expansion of gammadelta T cells among liver-derived lymphocytes of AIDS patients with disseminated Mycobacterium avium complex infection.
The aim of this study was to investigate a potential expansion of gammadelta T cells in AIDS patients in response to disseminated infection with Mycobacterium avium complex. Liver-derived lymphocytes and peripheral blood lymphocytes were obtained from 5 AIDS patients with disseminated Mycobacterium avium complex infection and 10 HIV-infected patients without mycobacterial disease. Control patients included 14 HIV-negative patients without bacterial disease and 4 HIV-negative patients with disseminated Mycobacterium tuberculosis infection. The percentage of gammadelta T cells among CD3+ T lymphocytes was determined by flow cytometry. gammadelta T cells were markedly enhanced in liver biopsies but not among peripheral blood lymphocytes of AIDS patients with disseminated M. avium complex infection (median liver gammadelta/CD3: 26%) as compared to HIV-infected control patients without mycobacterial disease (median liver gammadelta/CD3: 2.3%; P < 0,005). Disseminated infection with M. tuberculosis in HIV-negative patients leads to a similar expansion of gammadelta T cells among liver-derived CD3+ lymphocytes (median gammadelta/CD3: 15.5%) as compared to control patients without mycobacterial disease (median gammadelta/CD3: 2.15%; P < 0,001).
Gröttrup-Wolfers
E
E
Virchow-Klinikum, Humboldt-University Berlin, Berlin, 13353, Germany.
Grünewald
T
T
Strzelecki
R
R
Pohle
H D
HD
Ruf
B
B
D017088:AIDS-Related Opportunistic Infections / Q000097:blood*; D000328:Adult; D000368:Aged; D001706:Biopsy; D005260:Female; D006801:Humans; D008099:Liver / Q000737:chemistry / Q000166:cytology* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D015270:Mycobacterium avium-intracellulare Infection / Q000097:blood*; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000097:blood*
D016692:Receptors, Antigen, T-Cell, gamma-delta