[The immunological consequences of congenital infections].
Mice of different strains were inoculated with type A influenza virus or Mycoplasma arthritidis in the second half of pregnancy. A part of the animals born after this inoculation were characterized by a sharp retardation of growth. The study of the immune status of such animals revealed that their proliferative response to mitogenic/superantigenic factors of the infective agents introduced during pregnancy was suppressed or absent, and the cells of their immune system began to recognize syngeneic intact stimulators in the mixed lymphocytes culture as heterogeneous ones. The spleen of the experimental animals was found to contain suppressor cells, both specific and nonspecific with respect to the infective agent. After inoculation with M. arthritidis areactivity was observed only in mice, sensitive to mycoplasmal superantigen. The data thus obtained suggest that the penetration of infecting agents producing mitogenic/superantigenic factors induced changes in the immune system, contributing to the persistence of the infective agent in the host body.
Pronin
A V
AV
Deeva
A V
AV
Zuev
V A
VA
Mirchink
E P
EP
Rakovskaia
I V
IV
Alfimova
E Iu
EIu
D000818:Animals; D003601:Cytotoxicity Tests, Immunologic; D005260:Female; D009980:Influenza A virus; D007378:Interleukins / Q000097:blood; D007959:Lymphocyte Culture Test, Mixed; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009175:Mycoplasma Infections / Q000151:congenital* / Q000276:immunology*; D009976:Orthomyxoviridae Infections / Q000151:congenital* / Q000276:immunology*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D013154:Spleen / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis
D007378:Interleukins; D014409:Tumor Necrosis Factor-alpha