Short-term regulation of energy intake is intact in hypophagic tumor-bearing rats.
Anorexia and weight loss are major problems in the care of cancer patients. Data from laboratory studies using an animal model of tumor-induced anorexia suggest that energy intake may be regulated in the tumor-bearing host as it is in healthy animals. The purpose of the present study was to determine if hypophagic tumor-bearing rats would alter their food intake in response to manipulations known to affect food intake in normal healthy animals. Both tumor-bearing and healthy animals increased their food intake when housed at 22 versus 25 degrees C and reduced their food intake when injected with anorexigenic doses of bacterial lipopolysaccharide or interleukin-1 alpha. These data suggest that selected physiological responses affecting short-term food intake are intact in the hypophagic tumor bearing host.
McCarthy
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DO
School of Nursing, University of Wisconsin-Madison 53792, USA.
D000818:Animals; D000855:Anorexia / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology*; D006528:Carcinoma, Hepatocellular / Q000150:complications / Q000378:metabolism / Q000503:physiopathology*; D004195:Disease Models, Animal; D004435:Eating; D002149:Energy Intake; D008114:Liver Neoplasms, Experimental / Q000150:complications / Q000378:metabolism / Q000503:physiopathology*; D008297:Male; D051381:Rats; D013696:Temperature