title: CD6-ligand interactions: a paradigm for SRCR domain function?
abstract: The scavenger receptor cysteine-rich (SRCR) superfamily, which includes proteins expressed by leukocytes, can be subdivided into groups A and B. Group B contains the lymphocyte cell-surface receptor CD6. This article reviews recent progress in understanding the interaction between CD6 and its ligand, activated leukocyte cell adhesion molecule (ALCAM). Analysis of the CD6-ALCAM interaction may help to understand how other SRCR domains bind to their ligands.
authors.affiliation: Bristol-Myers Squibb Pharmaceutical Research Institute, Seattle, WA 98121, USA. aruffo@bms.com
authors.forename: A
authors.initials: A
authors.lastname: Aruffo
authors.forename: M A
authors.initials: MA
authors.lastname: Bowen
authors.forename: D D
authors.initials: DD
authors.lastname: Patel
authors.forename: B F
authors.initials: BF
authors.lastname: Haynes
authors.forename: G C
authors.initials: GC
authors.lastname: Starling
authors.forename: J A
authors.initials: JA
authors.lastname: Gebe
authors.forename: J
authors.initials: J
authors.lastname: Bajorath
mesh_terms: D020410:Activated-Leukocyte Cell Adhesion Molecule; D000595:Amino Acid Sequence; D000818:Animals; D015703:Antigens, CD / Q000276:immunology*; D000945:Antigens, Differentiation, T-Lymphocyte / Q000276:immunology*; D015815:Cell Adhesion Molecules / Q000276:immunology; D006023:Glycoproteins / Q000276:immunology; D006801:Humans; D008024:Ligands; D008565:Membrane Proteins; D008958:Models, Molecular; D008969:Molecular Sequence Data; D011956:Receptors, Cell Surface / Q000737:chemistry / Q000235:genetics / Q000276:immunology*; D011971:Receptors, Immunologic; D018110:Receptors, Lipoprotein; D051116:Receptors, Scavenger; D051122:Scavenger Receptors, Class B; D017386:Sequence Homology, Amino Acid
chemical_list: D020410:Activated-Leukocyte Cell Adhesion Molecule; D015703:Antigens, CD; D000945:Antigens, Differentiation, T-Lymphocyte; C062279:CD6 antigen; D015815:Cell Adhesion Molecules; D006023:Glycoproteins; D008024:Ligands; D008565:Membrane Proteins; D011956:Receptors, Cell Surface; D011971:Receptors, Immunologic; D018110:Receptors, Lipoprotein; D051116:Receptors, Scavenger; C454739:Scarb1 protein, mouse; D051122:Scavenger Receptors, Class B