title: [Topiramate, a new antiepileptic drug].
abstract: OBJECTIVE
  The characteristics of the new anti-epileptic drug topiramato (TPM) are described: multiple mechanism of action, favourable pharmaco-kinetics, wide therapeutic range and is relatively well tolerated, Development. Its initial usefulness in patients with partial crises resistant to other anti-epileptic drugs has been shown. TPM is equally effective in primary generalized crises, and in patients with the Lennox-Gastaut syndrome, in whom no problem of tolerance has been seen.
  
  
  CONCLUSIONS
  TPM is a valuable drug for the treatment of epilepsy.
authors.affiliation: Servicio de Neuropediatria, Hospital Universitario Marqués de Valdecilla, Facultad de Medicina, Santander, España.
authors.forename: J L
authors.initials: JL
authors.lastname: Herranz
mesh_terms: D000927:Anticonvulsants / Q000494:pharmacology / Q000627:therapeutic use; D004827:Epilepsy / Q000188:drug therapy; D005632:Fructose / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D000077236:Topiramate
chemical_list: D000927:Anticonvulsants; D000077236:Topiramate; D005632:Fructose