title: Treatment of refractory depression.
abstract: Treatment of refractory depression is a common challenge for mental health professionals. To assure optimal treatment, the clinician should first determine that adequate dosage has been employed for an adequate duration. Next there are a variety of augmentation strategies or alternative antidepressants that could be considered. This report reviews the evidence supporting these strategies, describes their implementation, compares their effectiveness, and offers suggestions for approaching the array of treatments available.
authors.affiliation: Yale University School of Medicine, New Haven, CT, USA.
authors.forename: J C
authors.initials: JC
authors.lastname: Nelson
mesh_terms: D000928:Antidepressive Agents / Q000627:therapeutic use*; D019090:Case Management; D003863:Depression / Q000188:drug therapy*; D004334:Drug Administration Schedule; D004351:Drug Resistance; D004359:Drug Therapy, Combination; D006801:Humans; D017410:Practice Guidelines as Topic; D011619:Psychotropic Drugs / Q000627:therapeutic use
chemical_list: D000928:Antidepressive Agents; D011619:Psychotropic Drugs