title: [Intragastric proteolysis after vagotomy in perforative duodenal ulcer].
abstract: The examination of intragastric proteolysis in patients operated on the perforative duodenal ulcer has been performed in 80 patients in the period up to 16 years after the surgery. The selective proximal vagotomy was performed in 65 of the patients, the trunk vagotomy--in 15 of the patients. In 55 patients the vagotomy was combined with ulcerrraphy, in 25 patients--with draining operations. The 30-35% decrease of the intragastric pepsin proteolysis was detected in patients after the vagotomy. There was no any signs of restoration of the suppressed proteolytic activity in the time period up to 16 years after the surgery. The draining operations lead to suppression of pepsin proteolysis in long-term period after the surgery and to its substitution with digestion with the pancreatic proteinases.
authors.affiliation: State Medical University, Kemerovo.
authors.forename: V I
authors.initials: VI
authors.lastname: Podoluzhnyí
authors.forename: S V
authors.initials: SV
authors.lastname: Ivanov
authors.forename: I V
authors.initials: IV
authors.lastname: Podoluzhnaia
mesh_terms: D004381:Duodenal Ulcer / Q000150:complications* / Q000601:surgery; D005500:Follow-Up Studies; D006801:Humans; D010439:Peptic Ulcer Perforation / Q000209:etiology / Q000601:surgery*; D010447:Peptide Hydrolases / Q000378:metabolism*; D011184:Postoperative Period; D013270:Stomach / Q000201:enzymology*; D013997:Time Factors; D014628:Vagotomy
chemical_list: D010447:Peptide Hydrolases