title: Euglena gracilis as an eukaryotic test organism for detecting mutagens and antimutagens.
abstract: The unicellular flagellate Euglena gracilis was used in order to assess the inhibition of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) and N-methyl-N-nitrosourea (MNU) mutagenicities, which induce white mutants due to the irreversible loss of chloroplasts. All tested compounds, including o-aminobenzoic acid and p-aminobenzoic acid, salicylic acid, acetylsalicylic acid, sodium salicylate and p-aminosalicylic acid, were not mutagenic per se and inhibited MNNG mutagenicity by at least 50%. The last two compounds inhibited by at least 50% also MNU mutagenicity.
authors.affiliation: Institute of Cellular Biology, Comenius University, Bratislava, Slovak Republic.
authors.forename: P
authors.initials: P
authors.lastname: Foltínová
authors.forename: J
authors.initials: J
authors.lastname: Grones
mesh_terms: D010129:4-Aminobenzoic Acid / Q000494:pharmacology; D010131:Aminosalicylic Acid / Q000494:pharmacology; D000818:Animals; D016587:Antimutagenic Agents / Q000494:pharmacology*; D001241:Aspirin / Q000494:pharmacology; D002736:Chloroplasts / Q000187:drug effects / Q000235:genetics; D005056:Euglena gracilis / Q000187:drug effects* / Q000235:genetics*; D005057:Eukaryotic Cells; D008769:Methylnitronitrosoguanidine / Q000633:toxicity; D008770:Methylnitrosourea / Q000633:toxicity; D009152:Mutagenicity Tests / Q000379:methods*; D009153:Mutagens / Q000633:toxicity*; D009154:Mutation; D010858:Pigmentation / Q000187:drug effects / Q000235:genetics; D012459:Salicylates / Q000494:pharmacology; D020156:Salicylic Acid; D012980:Sodium Salicylate / Q000494:pharmacology; D062367:ortho-Aminobenzoates / Q000494:pharmacology
chemical_list: D016587:Antimutagenic Agents; D009153:Mutagens; D012459:Salicylates; D062367:ortho-Aminobenzoates; C031385:anthranilic acid; D008769:Methylnitronitrosoguanidine; D010131:Aminosalicylic Acid; D008770:Methylnitrosourea; D020156:Salicylic Acid; D001241:Aspirin; D010129:4-Aminobenzoic Acid; D012980:Sodium Salicylate