Adherence as a particular issue with protease inhibitors.
Suboptimal therapeutic doses of HIV protease inhibitors lead to the emergence of drug resistance and reduced drug efficacy. It is imperative, then, that patients and clinicians alike are fully educated about the importance of patients taking all the pills in these new, admittedly complex, antiretroviral regimens. With protease inhibitors especially, missing doses and/or taking drug holidays or partial doses will mean the rapid emergence of HIV isolates that are resistant to these drugs.
Katzenstein
D A
DA
Stanford University Medical Center, CA, USA.
D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy*; D004352:Drug Resistance, Microbial; D019983:Guideline Adherence; D017320:HIV Protease Inhibitors / Q000627:therapeutic use*; D006801:Humans; D010349:Patient Compliance; D017410:Practice Guidelines as Topic; D012367:RNA, Viral / Q000187:drug effects
D017320:HIV Protease Inhibitors; D012367:RNA, Viral