[Role of bacterial lipopolysaccharides in human diseases: evolution of outlook].
The authors propose a new conception of the role of bacterial lipopolysaccharides (LPS) in human illnesses. Being a structural component of a great variety of gram-negative bacteria, upon the entrance of human body bacterial LPS serve as a biological signal indicative of bacterial invasion. This activates body defenses striving to limit the inflammatory focus, to arrest dissemination of the bacteria and their cleaning up. Such response of the body is feasible only in case of adequate function of the body defenses. Functional failure of the latter leads to inadequate response of the body which can not control systemic inflammation with polyorganic lesions.
Malov
V A
VA
Medico-Profilactic Faculty of MMA of IM Sechenov.
Pak
S G
SG
D015415:Biomarkers; D006090:Gram-Negative Bacteria / Q000378:metabolism* / Q000472:pathogenicity; D016905:Gram-Negative Bacterial Infections / Q000150:complications* / Q000378:metabolism; D006801:Humans; D011135:Polysaccharides, Bacterial / Q000378:metabolism*; D018805:Sepsis / Q000209:etiology* / Q000378:metabolism / Q000382:microbiology
D015415:Biomarkers; D011135:Polysaccharides, Bacterial