title: Prognostic significance of surgical margin in hepatocellular carcinoma resection: an analysis of 165 Childs' A patients.
abstract: OBJECTIVE
  The clinical significance of the width of the surgical margin in the resection of hepatocellular carcinoma (HCC) has yet to be clarified.
  
  
  METHODS
  Childs' A patients (165) who underwent resections of HCC were studied. Patients were divided into a wide margin group (1.0 cm or more, group W, n = 85), and a narrow margin group (< 1.0 cm, group N, n = 80).
  
  
  RESULTS
  Multivariate analysis showed that preoperative alpha-fetoprotein level (P = 0.0202), venous invasion (P = 0.0226), surgical margin (P = 0.0012), and TNM stage (P = 0.0023) were significant predictors of disease-free survival. By the log-rank test, the disease-free survival rate of the group W patients was significantly higher than that of the group N patients (P = 0.0007). Group N had a higher percentage of patients undergoing minor resection (wedge resection or subsegmentectomy) (44% vs. 26%, P = 0.016) and had a higher percentage of patients with centrally located tumor (62% vs. 29%, P = 0.000) than group W.
  
  
  CONCLUSIONS
  The results of this study indicated the significant influence of surgical margin on HCC recurrence after resection. Minor resection and centrally located tumor are factors related to a narrow surgical margin.
authors.affiliation: Department of Surgery, Veterans General Hospital-Taipei, Taiwan.
authors.forename: G Y
authors.initials: GY
authors.lastname: Chau
authors.forename: W Y
authors.initials: WY
authors.lastname: Lui
authors.forename: S H
authors.initials: SH
authors.lastname: Tsay
authors.forename: K L
authors.initials: KL
authors.lastname: King
authors.forename: C C
authors.initials: CC
authors.lastname: Loong
authors.forename: J H
authors.initials: JH
authors.lastname: Chiu
authors.forename: C W
authors.initials: CW
authors.lastname: Wu
authors.forename: F K
authors.initials: FK
authors.lastname: P'eng
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D006528:Carcinoma, Hepatocellular / Q000601:surgery*; D018572:Disease-Free Survival; D005260:Female; D006498:Hepatectomy / Q000379:methods; D006801:Humans; D008113:Liver Neoplasms / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011379:Prognosis