Does cytomegalovirus cause glomerular injury in renal allograft recipients?
The case of a 16-yr-old woman who received an ABO-incompatible renal allograft for end-stage renal disease due to membranoproliferative glomerulonephritis type I is presented. The patient's posttransplant course was complicated by cytomegalovirus (CMV) infection and the rare finding of glomerular CMV inclusions on renal biopsy. This article focuses on the pathology and pathogenesis of glomerular injury associated with CMV infection in renal allograft recipients and also reviews the epidemiology, clinical implications, diagnosis and management of CMV infection in these patients.
Birk
P E
PE
Department of Pediatrics, University of Minnesota, Minneapolis 55455, USA.
Chavers
B M
BM
D000293:Adolescent; D003587:Cytomegalovirus / Q000276:immunology; D003586:Cytomegalovirus Infections / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology* / Q000628:therapy*; D005260:Female; D015432:Glomerulonephritis, Membranoproliferative / Q000150:complications; D006801:Humans; D007167:Immunotherapy; D015994:Incidence; D007676:Kidney Failure, Chronic / Q000209:etiology / Q000601:surgery; D007678:Kidney Glomerulus / Q000473:pathology* / Q000821:virology; D016030:Kidney Transplantation / Q000009:adverse effects*; D012307:Risk Factors; D012698:Serologic Tests; D014184:Transplantation, Homologous / Q000009:adverse effects; D014765:Viral Vaccines / Q000008:administration & dosage*
D014765:Viral Vaccines