Detection of anti-PPD IgG antibody and PPD-induced delayed type hypersensitivity in anterior uveitis patients.
Present study relates to the results of anti-PPD IgG, anti-A60 and antinuclear antibodies and PPD-induced delayed type hypersensitivity (DTH) in 17 anterior uveitis, (AU) patients. Results of anti-PPD IgG assay revealed detection of higher mean antibody level (O.D. 0.11 +/- 0.06) compared to healthy controls (O.D. 0.04 +/- 0.03), other eye disease controls (O.D. 0.05 +/- 0.003) and leprosy controls (O.D. 0.03 +/- 0.03). Anti-A60 IgM antibody assay revealed insignificant differences in mean antibody levels between various groups. Four of 17(23.5%) AU patients and 1(5.8%) subject each, belonging to other eye disease and healthy control groups had raised anti-nuclear antibody index. Findings of PPD skin test revealed detection of moderate to strong (2 to 4+) reactivity in 14 (82%). AU patients. Conversely, 13(76%) healthy controls and 8(47%) other eye disease controls gave mild (1+) reactivity. Results of this study suggested possible role of hypersensitivity to mycobacterial antigens in pathogenesis of anterior uveitis.
Kapoor
A K
AK
Department of Pathology, K.G. Medical College, Lucknow.
Gopal
R
R
Lal
B
B
Asthana
O P
OP
Agarwal
P K
PK
Mukerjee
K
K
Saxena
R P
RP
Dhawan
P
P
D000974:Antibodies, Antinuclear / Q000097:blood; D000907:Antibodies, Bacterial / Q000097:blood; D016022:Case-Control Studies; D006801:Humans; D006968:Hypersensitivity, Delayed; D007074:Immunoglobulin G / Q000097:blood; D009169:Mycobacterium tuberculosis / Q000276:immunology / Q000472:pathogenicity; D014373:Tuberculin / Q000276:immunology*; D014606:Uveitis, Anterior / Q000209:etiology / Q000276:immunology*
D000974:Antibodies, Antinuclear; D000907:Antibodies, Bacterial; D007074:Immunoglobulin G; D014373:Tuberculin