title: Changes in regional blood flow in response to distension of the uterus in anaesthetised pigs.
abstract: The present study was undertaken in anaesthetised pigs to determine the primary reflex effects of distension of the uterus on the peripheral circulation. Experiments were performed in seven pigs anaesthetised with alpha-chloralose and artificially ventilated. Blood flow in the superior mesenteric, left renal and left external iliac arteries was assessed using electromagnetic flowmeters. Distension of the uterus was performed whilst preventing changes in heart rate and aortic blood pressure by injecting 20 ml of warm Ringer solution in a balloon positioned within the viscus (mean transmural pressure of about 18 mmHg). In each pig, distension of the uterus caused decreases in all measured blood flows. In four pigs, these decreases were graded by step increments of distension. In the seven pigs, the responses of decrease in mesenteric, renal and iliac blood flows were not affected by blockade of beta-adrenergic receptors with propranolol, but were abolished by the subsequent blockade of alpha-adrenergic receptors with phentolamine. The present study showed that distension of the uterus in anaesthetised pigs primarily caused reflex vasoconstriction in the mesenteric, renal and iliac vascular beds. This reflex response was mediated by sympathetic mechanisms which involved alpha vascular adrenergic receptors.
authors.affiliation: Dipartimento di Scienze Mediche, Facoltà di Medicina e Chirurgia di Novara, Università di Torino, Novara, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Vacca
authors.forename: A
authors.initials: A
authors.lastname: Battaglia
authors.forename: E
authors.initials: E
authors.lastname: Grossini
authors.forename: D A
authors.initials: DA
authors.lastname: Mary
authors.forename: C
authors.initials: C
authors.lastname: Molinari
authors.forename: N
authors.initials: N
authors.lastname: Surico
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000758:Anesthesia; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D005260:Female; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology; D007422:Intestines / Q000098:blood supply; D018482:Muscle, Skeletal / Q000098:blood supply; D009476:Neurons, Efferent / Q000187:drug effects / Q000502:physiology; D011433:Propranolol / Q000494:pharmacology; D012039:Regional Blood Flow / Q000187:drug effects / Q000502:physiology; D012079:Renal Circulation / Q000502:physiology; D013552:Swine; D013564:Sympathetic Nervous System / Q000187:drug effects / Q000502:physiology*; D014599:Uterus / Q000294:innervation / Q000502:physiology*
chemical_list: D000319:Adrenergic beta-Antagonists; D011433:Propranolol