title: The effects of blood pressure resting level and lability on cardiovascular reactions to laboratory stress.
abstract: Evidence that individuals with elevated resting blood pressures display excessive cardiovascular reactions to laboratory stress is regarded as implicating excessive reactivity in the pathogenesis of hypertension. However, it remains possible that this relationship is artifactual, in that resting blood pressure levels and cardiovascular reactions might both reflect intrinsic cardiovascular lability. To examine this possibility, blood pressure and heart rate were measured at rest and in response to an active laboratory stressor in 1259 men. Systolic blood pressure and heart rate reactions to the stressor were predicted by resting blood pressure. Although cardiovascular lability showed some association with both reactivity and resting blood pressure level, the resting blood pressure level-reactivity relationship survived statistical adjustment for such associations. Accordingly, the excessive cardiovascular reactions characteristic of individuals with elevated resting blood pressure would not appear to be explainable, to any substantial extent, by lability effects.
authors.affiliation: Division of Cardiology, University of North Carolina at Chapel Hill 27599-7075, USA.
authors.forename: D
authors.initials: D
authors.lastname: Sheffield
authors.forename: G D
authors.initials: GD
authors.lastname: Smith
authors.forename: D
authors.initials: D
authors.lastname: Carroll
authors.forename: M J
authors.initials: MJ
authors.lastname: Shipley
authors.forename: M G
authors.initials: MG
authors.lastname: Marmot
mesh_terms: D000328:Adult; D001794:Blood Pressure / Q000502:physiology*; D002320:Cardiovascular Physiological Phenomena; D005260:Female; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D012189:Retrospective Studies; D013315:Stress, Psychological / Q000503:physiopathology*