Systemic lupus: from the bedside to the laboratory bench.
The author highlights some of the clinical, biological and serological signs associated with systemic lupus erythematosus and use them as keys to enter into the most recent advances in the immunopathology of the disease, in particular the mechanisms underlying the production of pathogenic autoantibodies.
Houssiau
F A
FA
Service de Rhumatologie, Cliniques Universitaires Saint-Luc, Bruxelles, Belgium.
D000974:Antibodies, Antinuclear / Q000032:analysis; D001323:Autoantibodies / Q000096:biosynthesis / Q000276:immunology; D001324:Autoantigens / Q000032:analysis; D001327:Autoimmune Diseases / Q000097:blood / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology; D001402:B-Lymphocytes / Q000276:immunology; D004247:DNA / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology; D008181:Lupus Nephritis / Q000276:immunology / Q000473:pathology; D008213:Lymphocyte Activation / Q000276:immunology; D020733:RNA, Small Cytoplasmic; D012261:Ribonucleoproteins / Q000032:analysis; D013601:T-Lymphocytes / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology; D000099207:SS-A Antigen
D000974:Antibodies, Antinuclear; D001323:Autoantibodies; D001324:Autoantigens; D004247:DNA; D007074:Immunoglobulin G; D020733:RNA, Small Cytoplasmic; D012261:Ribonucleoproteins; D000099207:SS-A Antigen; C116006:RO60 protein, human