Bacterial protein secretion--a target for new antibiotics?
The heavy use of antibiotics over recent decades has resulted in widespread resistance of bacteria to many drugs. Overcoming resistance requires new approaches to antibiotic development, including the exploitation of new targets in the bacterial cell. Protein secretion is essential for bacterial cell growth and virulence, so it could be a suitable target for new therapeutic agents.
Stephens
C
C
Department of Biology, Santa Clara University, CA 95053, USA. cstephens@mailer.scu.edu
Shapiro
L
L
D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001426:Bacterial Proteins / Q000187:drug effects / Q000378:metabolism*; D015195:Drug Design
D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins