title: Anti-platelet aggregation activity of some pyrazines.
abstract: This report describes the anti-platelet aggregation activity of 48 pyrazines. Among alkyl- and arylpyrazines tested, 2,3-diphenylpyrazines showed the strongest anti-platelet aggregation activity. Then, various substituents were introduced into the phenyl groups, and the 2,3-bis(p-methoxyphenyl)pyrazine derivatives were consequently found to possess considerably strong inhibitory activity.
authors.affiliation: Tokyo University of Pharmacy and Life Science, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Ohta
authors.forename: H
authors.initials: H
authors.lastname: Takahashi
authors.forename: N
authors.initials: N
authors.lastname: Miyata
authors.forename: H
authors.initials: H
authors.lastname: Hirono
authors.forename: T
authors.initials: T
authors.lastname: Nishio
authors.forename: E
authors.initials: E
authors.lastname: Uchino
authors.forename: K
authors.initials: K
authors.lastname: Yamada
authors.forename: Y
authors.initials: Y
authors.lastname: Aoyagi
authors.forename: Y
authors.initials: Y
authors.lastname: Suwabe
authors.forename: M
authors.initials: M
authors.lastname: Fujitake
authors.forename: T
authors.initials: T
authors.lastname: Suzuki
authors.forename: K
authors.initials: K
authors.lastname: Okamoto
mesh_terms: D000818:Animals; D016718:Arachidonic Acid / Q000633:toxicity; D003094:Collagen / Q000633:toxicity; D004353:Drug Evaluation, Preclinical; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D011719:Pyrazines / Q000737:chemistry / Q000494:pharmacology*; D011817:Rabbits; D013329:Structure-Activity Relationship
chemical_list: D010975:Platelet Aggregation Inhibitors; D011719:Pyrazines; D016718:Arachidonic Acid; D003094:Collagen