Soluble E-selectin and intercellular adhesion molecule-1 plasma levels increase during acute myocardial infarction.
Previous studies have shown that adhesion molecules play a crucial role in leukocyte-endothelium interactions that occur during myocardial ischemia and reperfusion. We assessed the plasma levels of the soluble form of E-selectin (sE-selectin) and intercellular adhesion molecule-1 (sICAM-1) in 15 patients with acute myocardial infarction (AMI) and in 15 controls with chronic stable angina. In patients with AMI, the levels of sE-selectin and sICAM-1 increased significantly during the first 8 h after infarction and subsequently decreased. Soluble E-selectin levels were inversely related to the peak plasma levels of creatine kinase-MB (CK-MB), and the time course of their appearance in plasma correlated with that of neutrophil count and plasma D-dimer. In individual patients, peak and mean sICAM-1 levels correlated respectively with plasma D-dimer concentrations and monocyte count, but no correlation were found when their time courses were analyzed. Eight hours after symptom onset, the mean plasma sE-selectin levels were higher in patients with AMI than in those with stable angina, whereas no significant differences were found in mean plasma sICAM-1 levels between the two groups at every time analyzed. In the acute phase of MI (a) sE-selectin and sICAM-1 levels increase during the first 8 h and subsequently decrease; (b) the increase in sE-selectin probably reflects activation of endothelial cells, correlates with other inflammatory and coagulation parameters, and is inversely related to the degree of myocardial damage; and (c) sICAM-1 plasma levels do not represent a good marker of "cell activation" because they reflect activation of different cells and may be affected by different conditions.
Pellegatta
F
F
Laboratory of Cadiovascular Pathophysiology, Istituto Scientifico San Raffaele, Milan, Italy.
Pizzetti
G
G
Lu
Y
Y
Radaelli
A
A
Pomes
D
D
Carlino
M
M
Meloni
C
C
Belotti
G
G
Galli
L
L
Vidal
M J
MJ
Chierchia
S L
SL
D000328:Adult; D000368:Aged; D003402:Creatine Kinase / Q000097:blood*; D019040:E-Selectin / Q000097:blood*; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D007527:Isoenzymes; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood*
D019040:E-Selectin; D007527:Isoenzymes; D018799:Intercellular Adhesion Molecule-1; D003402:Creatine Kinase