title: [Analysis of observations in the admissions room of the Krakow Clinical Toxicology Department of substance dependent persons in relation to changes in central nervous system metabolism caused by substances of abuse].
abstract: Authors presented the course of clinical observation of 393 acutely intoxicated patients dependent on psychoactive substances (28%) or ethanol (72%) who were discharged from the hospital at their own request before diagnosis and treatment were completed. In the first stage of detoxification the different intensity symptoms of toxic coma (25% of patients), behavioral changes-agitation and aggression (16%) and also the disturbances in consciousness accompanied by tremor and vegetative storm (15%) were observed. Authors pointed out that among others the neurobiological changes in brain reward systems of patients who discontinued diagnosis and treatment could be endangering for both the patient and the doctor. They postulate that criteria of life threatening state should by more accurately defined and the methods of full security for patient and doctors should be worked out.
authors.affiliation: Kliniki Toksykologii Collegium Medicum, Uniwersytetu Jagiellońskiego w Krakowie.
authors.forename: J
authors.initials: J
authors.lastname: Chrostek Maj
authors.forename: J
authors.initials: J
authors.lastname: Pach
authors.forename: D
authors.initials: D
authors.lastname: Targosz
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000437:Alcoholism / Q000150:complications* / Q000378:metabolism / Q000628:therapy; D001921:Brain / Q000378:metabolism*; D003128:Coma / Q000139:chemically induced* / Q000453:epidemiology / Q000628:therapy; D003244:Consciousness Disorders / Q000139:chemically induced* / Q000453:epidemiology / Q000628:therapy; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D001523:Mental Disorders / Q000139:chemically induced* / Q000453:epidemiology / Q000628:therapy; D008875:Middle Aged; D019966:Substance-Related Disorders / Q000150:complications* / Q000378:metabolism / Q000628:therapy