Propofol produces anticonflict action by inhibiting 5-HT release in rat dorsal hippocampus.
We examined the effect of propofol, an injectable anesthetic agent on conflict behavior in a Vogel type conflict test and on release of serotonin (5-hydroxytryptamine, 5-HT) in the dorsal hippocampus using an in vivo microdialysis method in rats. Propofol (20 and 40 mg/kg, i.p.) dose-dependently suppressed elevated 5-HT release normally seen in a conflict situation and concomitantly attenuated conflict behavior. These findings suggest that propofol exerts an antianxiety action by inhibiting 5-HT neuronal activity in the dorsal hippocampus.
Matsuo
M
M
Department of Dental Anesthesiology, Nagasaki University Dental Hospital, Japan.
Ayuse
T
T
Oi
K
K
Kataoka
Y
Y
D018686:Anesthetics, Intravenous / Q000494:pharmacology*; D000818:Animals; D003220:Conflict, Psychological; D006624:Hippocampus / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D017551:Microdialysis; D015742:Propofol / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012701:Serotonin / Q000378:metabolism*
D018686:Anesthetics, Intravenous; D012701:Serotonin; D015742:Propofol