Effect of vitamin C supplementation on oxidative stress in experimental diabetes.
Alloxan diabetic rats supplemented with vitamin C (ascorbic acid) orally in drinking water had increased plasma and liver ascorbic acid as compared to unsupplemented diabetic rats. The levels of liver reduced glutathione also increased in vitamin C supplemented diabetic rats as compared to non-supplemented diabetic rats. Vitamin C supplementation did not have any effect in reducing increased liver lipid peroxidation in diabetic rats. The results of the present study suggest that diabetes results in decreased levels of protective antioxidant species and vitamin C is effective to some extent in maintaining levels of plasma and liver ascorbic acid and liver reduced glutathione.
Garg
M C
MC
Department of Biochemistry, Panjab University, Chandigarh, India.
Singh
K P
KP
Bansal
D D
DD
D000818:Animals; D001205:Ascorbic Acid / Q000627:therapeutic use*; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D019587:Dietary Supplements; D005260:Female; D018384:Oxidative Stress; D051381:Rats; D017207:Rats, Sprague-Dawley
D001205:Ascorbic Acid