[Carotid baroreflex in sleep apnea patients].
15 patients (11 male, 9 female) with obstructive sleep apnoea syndrome (OSAS) and 10 healthy age- and weight-matched control subjects volunteered to participate in the study to test circadian variations of cardiac response to activation of carotid baroreceptors. Activation of carotid baroreceptors was evoked by applying a negative pressure to both left and right carotid sinus regions, using two small separate neck-suction capsules. All experiments were performed under standard conditions every two hours. The cardiac response to carotid baroreceptors activation was significantly reduced in OSAS Patients, to a greater degree in the group of hypertensive patients. A characteristic circadian rhythm of baroreceptor reactivity persisted in all OSAS patients. Thus, OSAS patients constitute a high-risk group for the development of cardiovascular diseases and pathological course of blood pressure during daytime.
Klawe
J J
JJ
Medizinische Poliklinik, Schlafmedizinisches Labor, Universität Marburg.
Tafil-klawe
M
M
Grote
L
L
Schneider
H
H
Peter
J H
JH
Marcyniak
M
M
Szajnoch
W
W
D001794:Blood Pressure / Q000502:physiology; D002346:Carotid Sinus / Q000294:innervation*; D002940:Circadian Rhythm / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011311:Pressoreceptors / Q000503:physiopathology*; D012016:Reference Values; D012021:Reflex, Abnormal / Q000502:physiology*; D012891:Sleep Apnea Syndromes / Q000175:diagnosis / Q000503:physiopathology*