A critical review of 5-HT brain microdialysis and behavior.
Serotonin (5-HT) has been implicated in many central nervous system-mediated functions including sleep, arousal, feeding, motor activity and the stress response. In order to help establish the precise role of 5-HT in physiology and behavior, in vivo microdialysis studies have sought to identify the conditions under which the release of 5-HT is altered. Extracellular 5-HT levels have been monitored in more than fifteen regions of the brain during a variety of spontaneous behaviors, and in response to several physiological, environmental, and behavioral manipulations. The vast majority of these studies found increases (30-100%) in 5-HT release in almost all brain regions studied. Since electrophysiological studies have shown that behavioral arousal is the primary determinant of brain serotonergic neuronal activity, we suggest that the increase in 5-HT release seen during a wide variety of experimental conditions is largely due to one factor, namely an increase in behavioral arousal/motor activity associated with the manipulation.
Rueter
L E
LE
Department of Psychology, Princeton University, NJ 08544-1010, USA.
Fornal
C A
CA
Jacobs
B L
BL
D000200:Action Potentials / Q000187:drug effects; D000374:Aggression / Q000187:drug effects / Q000502:physiology; D000818:Animals; D001007:Anxiety / Q000503:physiopathology; D001143:Arousal / Q000502:physiology*; D001362:Avoidance Learning / Q000187:drug effects / Q000502:physiology; D001519:Behavior / Q000187:drug effects / Q000502:physiology*; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology; D001923:Brain Chemistry; D002415:Cats; D002940:Circadian Rhythm / Q000187:drug effects / Q000502:physiology; D005110:Extracellular Space / Q000737:chemistry; D005247:Feeding Behavior / Q000187:drug effects / Q000502:physiology; D006801:Humans; D017551:Microdialysis; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology; D010146:Pain / Q000503:physiopathology; D011903:Raphe Nuclei / Q000502:physiology; D051381:Rats; D012701:Serotonin / Q000032:analysis / Q000494:pharmacology / Q000502:physiology*; D012756:Sheep; D013312:Stress, Physiological / Q000503:physiopathology
D012701:Serotonin