Molecular basis of antimicrobial resistance in non-typable Haemophilus influenzae.
Strains of the facultative anaerobe Haemophilus influenzae, both type b and non typable strains, are frequently multiresistant. The measurement of the antibiotic permeability of Haemophilus influenzae outer membrane (OM) shows that antibiotics can cross through the OM easily. Thus, enzymatic activity or efflux pumps could be responsible for multiresistance. An efflux system closely related to AcrAB of Escherichia coli is present in Haemophilus influenzae. However, their role in multiresistance seems irrelevant. Classical mechanisms such as plasmid exchange seems to be playing a major role in the multidrug resistance in Haemophilus influenzae.
Sánchez
L
L
Laboratori de Microbiologia, Institut Universitari de Salut Pública, Universitat de Barcelona, Spain.
Leranoz
S
S
Puig
M
M
Lorén
J G
JG
Nikaido
H
H
Viñas
M
M
D000900:Anti-Bacterial Agents / Q000378:metabolism; D001425:Bacterial Outer Membrane Proteins / Q000502:physiology; D001426:Bacterial Proteins / Q000235:genetics / Q000502:physiology; D001692:Biological Transport; D001693:Biological Transport, Active; D002352:Carrier Proteins; D002463:Cell Membrane Permeability; D004352:Drug Resistance, Microbial / Q000235:genetics / Q000502:physiology*; D018432:Drug Resistance, Multiple / Q000235:genetics / Q000502:physiology*; D029968:Escherichia coli Proteins; D006193:Haemophilus influenzae / Q000187:drug effects* / Q000235:genetics / Q000502:physiology; D008074:Lipoproteins / Q000235:genetics / Q000502:physiology; D008565:Membrane Proteins / Q000235:genetics / Q000502:physiology; D026901:Membrane Transport Proteins; D027425:ATP-Binding Cassette, Sub-Family C Proteins; D011815:R Factors
D000900:Anti-Bacterial Agents; D001425:Bacterial Outer Membrane Proteins; D001426:Bacterial Proteins; D002352:Carrier Proteins; D029968:Escherichia coli Proteins; D008074:Lipoproteins; D008565:Membrane Proteins; D026901:Membrane Transport Proteins; D027425:ATP-Binding Cassette, Sub-Family C Proteins; C083497:AcrA protein, E coli; C083496:AcrB protein, E coli