Multifaceted roles for IGFBP-1 in human endometrium during implantation and pregnancy.
IGFBP-1 is a major protein product of nonpregnant endometrium during the mid-late secretory phase and occurs in abundance in decidua. Its roles as an IGF-binding protein and as a trophoblast integrin ligand suggest that it may have multiple roles in endometrial development and in interactions between the decidua and the invading trophoblast. IGFBP-1 in vaginal/cervical secretions has already had clinical application as a predictor of premature rupture of fetal membranes. The future awaits elucidation of the potential utility of IGFBP-1 in serum and in decidua in predicting fetal growth restriction and preeclampsia and perhaps implantation failure.
Giudice
L C
LC
Department of Gynecology and Obstetrics, Stanford University Medical Center, California 94305-5317, USA.
D010064:Embryo Implantation / Q000502:physiology*; D004717:Endometrium / Q000502:physiology*; D005260:Female; D006801:Humans; D018970:Insulin-Like Growth Factor Binding Protein 1 / Q000502:physiology*; D011247:Pregnancy / Q000502:physiology*
D018970:Insulin-Like Growth Factor Binding Protein 1