Inherent abnormalities in oxidative metabolism in Alzheimer's disease: interaction with vascular abnormalities.
Extensive studies over the last 20 years have documented the existence of inherent abnormalities in oxidative/energy metabolism in Alzheimer's disease (AD). These abnormalities can be linked to characteristics of AD by plausible pathophysiological mechanisms for which there is abundant, robust evidence. The inherent abnormalities in cerebral metabolism of oxygen and glucose can reasonably be expected to interact synergistically with vascular compromise of cerebral oxygen and glucose metabolism in causing brain damage in AD.
Blass
J P
JP
Burke Medical Research Institute, Cornell University, White Plains, New York, USA. jpblass@mail.med.cornell.edu
Sheu
K F
KF
Piacentini
S
S
Sorbi
S
S
D000544:Alzheimer Disease / Q000378:metabolism* / Q000473:pathology; D001921:Brain / Q000378:metabolism; D002560:Cerebrovascular Circulation; D004734:Energy Metabolism; D005947:Glucose / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D010100:Oxygen / Q000378:metabolism*
D005947:Glucose; D010100:Oxygen