The use of lidocaine as a test of liver function in liver transplantation.
The hepatic metabolism of lidocaine to monoethyl-glycinexylidide (MEGX) is the basis of a dynamic test of liver function. To understand its potential value in liver transplantation, the latter has been considered in the following three separate stages: pretransplantation assessment of potential candidates, potential liver donors, and the transplant recipient. In pretransplantation patients, data support its role in assessing risk of morbidity and mortality. In assessment of the liver transplant donor, there are differences concerning apparent usefulness, and these must be resolved. In the liver transplant recipient, serial measurements are useful to measure real-time hepatic metabolic activity. Low MEGX values reflect the clinical condition of the patient, and the importance of entirely assessing the patient, not just noting the test result, is paramount. This review has considered the role of the MEGX test in liver transplantation.
Potter
J M
JM
Department of Clinical Pharmacology, Princess Alexandra Hospital, Brisbane, Queensland, Australia.
Oellerich
M
M
D006801:Humans; D008012:Lidocaine / Q000031:analogs & derivatives* / Q000097:blood / Q000378:metabolism; D008111:Liver Function Tests / Q000379:methods*; D016031:Liver Transplantation
D008012:Lidocaine; C001173:monoethylglycinexylidide