In vitro antimalarial activity of penduline, a bisbenzylisoquinoline from Isopyrum thalictroides.
Two bisbenzylisoquinolines, tetrandrine and penduline, were purified from Isopyrum thalictroides. When tested for antimalarial activity in vitro, penduline was efficient at concentrations fivefold lower than those of tetrandrine. In highly synchronized parasite cultures, penduline mostly interfered between the 8th and the 32nd hours of the parasite cycle.
Valentin
A
A
Laboratoire d'Immunologie et Parasitologie, UFR Sciences Pharmaceutiques, Montpellier, France.
Benoit-Vical
F
F
Moulis
C
C
Stanislas
E
E
Mallié
M
M
Fouraste
I
I
Bastide
J M
JM
D000470:Alkaloids / Q000302:isolation & purification / Q000494:pharmacology*; D000962:Antimalarials / Q000302:isolation & purification / Q000494:pharmacology*; D044182:Benzylisoquinolines; D002738:Chloroquine / Q000494:pharmacology; D004912:Erythrocytes / Q000469:parasitology; D005347:Fibroblasts / Q000187:drug effects; D006801:Humans; D007546:Isoquinolines / Q000302:isolation & purification / Q000494:pharmacology*; D016778:Malaria, Falciparum / Q000469:parasitology; D009101:Multiple Myeloma; D010936:Plant Extracts / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet; D014407:Tumor Cells, Cultured
D000470:Alkaloids; D000962:Antimalarials; D044182:Benzylisoquinolines; D007546:Isoquinolines; D010936:Plant Extracts; C009438:tetrandrine; D002738:Chloroquine; C027870:berbamine