title: Bicyclo[2.2.1]heptane and 6,6-dimethylbicyclo[3.1.1]heptane derivatives: orally active, potent, and selective prostaglandin D2 receptor antagonists.
authors.affiliation: Shionogi Research Laboratories, Shionogi & Co., Ltd., Osaka, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Tsuri
authors.forename: T
authors.initials: T
authors.lastname: Honma
authors.forename: Y
authors.initials: Y
authors.lastname: Hiramatsu
authors.forename: T
authors.initials: T
authors.lastname: Okada
authors.forename: H
authors.initials: H
authors.lastname: Hashizume
authors.forename: S
authors.initials: S
authors.lastname: Mitsumori
authors.forename: M
authors.initials: M
authors.lastname: Inagaki
authors.forename: A
authors.initials: A
authors.lastname: Arimura
authors.forename: K
authors.initials: K
authors.lastname: Yasui
authors.forename: F
authors.initials: F
authors.lastname: Asanuma
authors.forename: J
authors.initials: J
authors.lastname: Kishino
authors.forename: M
authors.initials: M
authors.lastname: Ohtani
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D001792:Blood Platelets / Q000187:drug effects; D001643:Bridged Bicyclo Compounds / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D006168:Guinea Pigs; D006801:Humans; D009636:Norbornanes / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D015230:Prostaglandin D2 / Q000378:metabolism*; D011971:Receptors, Immunologic; D011982:Receptors, Prostaglandin / Q000008:administration & dosage* / Q000378:metabolism; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D001643:Bridged Bicyclo Compounds; D009636:Norbornanes; D011971:Receptors, Immunologic; D011982:Receptors, Prostaglandin; D015230:Prostaglandin D2; C036293:prostaglandin D2 receptor