title: Influence of family history of hypertension on insulin sensitivity in lean and obese hypertensive subjects.
abstract: We evaluated the influence of family history of hypertension on insulin sensitivity in lean and obese hypertensive subjects (H): 40 lean [body mass index (BMI) < or = 25 kg m-2] H with normotensive parents (F-), 50 lean H with one or two parents hypertensive (F+), 30 obese HF- (BMI > or = 30 kg m-2) and 35 obese HF+. The four groups were comparable in terms of age, sex and ambulatory blood pressure values. We evaluated glucose, insulin and C-peptide before and 30, 60, 90 and 120 min after an oral glucose load, insulin sensitivity index (ISI, fasting glucose/insulin ratio), fasting insulin/C-peptide ratio (I/Cp). Glucose, fasting and during test, and I/Cp were similar among the four groups; insulin and C-peptide, fasting and stimulated, were significantly higher and ISI lower in obese H than in lean H; at similar BMI, insulin and C-peptide were significantly higher in F+ than in F-. Insulin directly correlated with night-time blood pressure only in lean HF-. The correlation between insulin and BMI was significantly closer in F-than in F+. In conclusion, family history of hypertension appears to play a relevant role in insulin sensitivity in hypertensive subjects also in the presence of obesity.
authors.affiliation: Department of Clinical and Biological Sciences, II Faculty of Medicine, University of Pavia, Varese, Italy.
authors.forename: A M
authors.initials: AM
authors.lastname: Grandi
authors.forename: G
authors.initials: G
authors.lastname: Gaudio
authors.forename: A
authors.initials: A
authors.lastname: Fachinetti
authors.forename: P
authors.initials: P
authors.lastname: Zanzi
authors.forename: L
authors.initials: L
authors.lastname: Bianchi
authors.forename: L
authors.initials: L
authors.lastname: Ceriani
authors.forename: L
authors.initials: L
authors.lastname: Guasti
authors.forename: A
authors.initials: A
authors.lastname: Venco
mesh_terms: D000328:Adult; D000375:Aging; D001786:Blood Glucose / Q000032:analysis*; D001794:Blood Pressure; D015992:Body Mass Index; D001835:Body Weight; D002096:C-Peptide / Q000097:blood; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000150:complications / Q000235:genetics*; D007328:Insulin / Q000097:blood / Q000494:pharmacology*; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood* / Q000150:complications; D012044:Regression Analysis; D012727:Sex Characteristics
chemical_list: D001786:Blood Glucose; D002096:C-Peptide; D007328:Insulin