The influence of dosage form on aspirin kinetics: implications for acute cardiovascular use.
In this study, the pharmacokinetics of several formulations of aspirin were examined: soluble aspirin, mouth-dispersible aspirin, plain aspirin and enteric-coated aspirin granules. Blood samples were taken at frequent intervals for 24 hours after single dosing in 12 healthy volunteers and Tmax, Cmax and t1/2 measured. Cmax was significantly higher for soluble aspirin than for the other formulations and the t1/2 was shorter. The results show the rapid absorption of aspirin from a soluble formulation compared with that from plain aspirin or enteric-coated aspirin granules. Recommendations to treat patients suspected of having a heart attack as soon as possible with aspirin are now widely accepted and the present study would suggest that soluble aspirin should be the aspirin of choice in this situation.
Muir
N
N
Reckitt and Colman plc, HULL, UK.
Nichols
J D
JD
Clifford
J M
JM
Stillings
M R
MR
Hoare
R C
RC
D000328:Adult; D001241:Aspirin / Q000737:chemistry* / Q000493:pharmacokinetics* / Q000627:therapeutic use; D001682:Biological Availability; D002626:Chemistry, Pharmaceutical; D018592:Cross-Over Studies; D016903:Drug Monitoring; D006801:Humans; D007408:Intestinal Absorption; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy; D010975:Platelet Aggregation Inhibitors / Q000737:chemistry* / Q000493:pharmacokinetics* / Q000627:therapeutic use; D012995:Solubility; D013608:Tablets, Enteric-Coated; D013997:Time Factors
D010975:Platelet Aggregation Inhibitors; D013608:Tablets, Enteric-Coated; D001241:Aspirin