Subcapsular cell hyperplasia and mast cell infiltration in the adrenal cortex of mice: comparative study in 7 inbred strains.
Subcapsular cell hyperplasia (SCH) in the adrenal cortex of aged mice (13-15 months old) was frequent in both sexes of BALB/c, C3H/He, DBA/2J and IQI/Jic mice and in the females of A/J and C57BL/6, although the incidence and severity of SCH were considerably different among mouse strains. Mast cells were closely associated with SCH in the A/J, BALB/c, C57BL/6, DBA/2J and IQI/Jic mice, but not in the C3H/He strain. Compared with other strains, IQI/Jic mice had a significantly larger number of mast cells in the adrenal glands. Our findings suggest that mast cells may participate in the development of SCH, and IQI/Jic would be suitable for studying the pathogenesis of SCH and the role of mast cells in this lesion.
Kim
J S
JS
Laboratory of Experimental Toxicology, National Institute of Industrial Health, Kawasaki, Japan.
Kubota
H
H
Kiuchi
Y
Y
Doi
K
K
Saegusa
J
J
D000303:Adrenal Cortex Diseases / Q000209:etiology / Q000473:pathology / Q000662:veterinary*; D000311:Adrenal Glands / Q000166:cytology / Q000473:pathology*; D000818:Animals; D005260:Female; D006965:Hyperplasia / Q000209:etiology; D008297:Male; D008407:Mast Cells / Q000502:physiology*; D051379:Mice; D008815:Mice, Inbred Strains / Q000033:anatomy & histology*