Melanin-concentrating hormone (MCH) involvement in pentylenetetrazole (PTZ)-induced seizure in rat and guinea pig.
Intraperitoneal injection of 60 mg/kg of pentylenetetrazole (PTZ) induced seizure in rats, but was subthreshold and did not result in seizure in guinea pigs. Three days after intracerebroventricular (i.c.v.) injection of 75 micrograms 6-hydroxydopamine (6-OHDA) in guinea pigs, PTZ induced seizures similar to those seen in rats. In both rats and 6-OHDA-treated guinea pigs, i.c.v. injection of melanin-concentrating hormone (MCH) 15 min before PTZ prevented seizure activity. These results suggest that MCH-containing neurons may participate in the neural circuits involved in expression of PTZ-induced seizure.
Knigge
K M
KM
Laboratory for Neuroendocrine Research, University of Rochester, School of Medicine, NY 14642, USA.
Wagner
J E
JE
D000818:Animals; D003292:Convulsants / Q000633:toxicity*; D005260:Female; D006168:Guinea Pigs; D007028:Hypothalamic Hormones / Q000494:pharmacology / Q000502:physiology*; D008297:Male; D008543:Melanins / Q000494:pharmacology / Q000502:physiology*; D009474:Neurons / Q000502:physiology; D016627:Oxidopamine / Q000633:toxicity; D010433:Pentylenetetrazole / Q000633:toxicity*; D010907:Pituitary Hormones / Q000494:pharmacology / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012640:Seizures / Q000209:etiology* / Q000503:physiopathology*; D013045:Species Specificity
D003292:Convulsants; D007028:Hypothalamic Hormones; D008543:Melanins; D010907:Pituitary Hormones; C019463:melanin-concentrating hormone; D016627:Oxidopamine; D010433:Pentylenetetrazole