Indomethacin in the management of elevated intracranial pressure: a review.
Elevated intracranial pressure occurs frequently in patients with severe head injury. A number of studies in recent years suggest that indomethacin may be useful in the management of elevated intracranial pressure. Indomethacin acts primarily by reducing cerebral blood flow and decreasing cerebral edema following head injury. This review summarizes the basic and clinical studies of the effects of indomethacin on cerebral blood flow, brain edema, and intracranial pressure. The pharmacology of indomethacin, and issues for future investigation in the use of indomethacin in severe head injury, are discussed.
Harrigan
M R
MR
Department of Surgery, University of Michigan Medical Center, and College of Pharmacy, Ann Arbor, USA.
Tuteja
S
S
Neudeck
B L
BL
D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D001929:Brain Edema / Q000188:drug therapy* / Q000503:physiopathology; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D002986:Clinical Trials as Topic; D006259:Craniocerebral Trauma / Q000150:complications* / Q000503:physiopathology; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology*; D004195:Disease Models, Animal; D006801:Humans; D007213:Indomethacin / Q000494:pharmacology*; D007427:Intracranial Pressure / Q000187:drug effects*
D016861:Cyclooxygenase Inhibitors; D007213:Indomethacin