title: Disturbed striatoprefrontal mediated visual behaviour in moderate to severe parkinsonian patients.
abstract: OBJECTIVE
  To study visuospatial and visual memory functions in moderate to severe parkinsonian patients.
  
  
  METHODS
  Visual antisaccades (AS) and remembered saccades (RS) were examined in 30 patients with moderate to severe Parkinson's disease and in 44 age matched controls. AS are saccades in the direction opposite to the target. RS are saccades towards the remembered position of a target that is no longer visible.
  
  
  RESULTS
  Patients with Parkinson's disease had serious difficulties in suppressing a reflex saccade ("visual grasping") or they made no saccade at all ("visual akinesia"). The remembered saccade was often wrongly directed.
  
  
  CONCLUSIONS
  These types of errors point to a dysfunction in the striatoprefrontal loop. The discrepancy of the results with those in the literature, which are mostly normal, could be explained by the more advanced stage of our patients. This might correspond to the development of unresponsiveness to levodopa or of non-dopaminergic lesions.
authors.affiliation: Department of Neurology, University of Ghent, Belgium.
authors.forename: L
authors.initials: L
authors.lastname: Crevits
authors.forename: K
authors.initials: K
authors.lastname: De Ridder
mesh_terms: D000328:Adult; D000978:Antiparkinson Agents / Q000627:therapeutic use; D003342:Corpus Striatum / Q000503:physiopathology*; D004585:Electrooculography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000188:drug therapy / Q000503:physiopathology*; D017397:Prefrontal Cortex / Q000503:physiopathology*; D012438:Saccades; D012720:Severity of Illness Index
chemical_list: D000978:Antiparkinson Agents