title: [Dynamic 31-phosphorus magnetic resonance spectroscopy of the m. quadriceps: therapy-induced changes in arterial occlusive disease].
abstract: OBJECTIVE
  The present investigation aimed at examining changes in muscle metabolism caused by treatment of arterial occlusive disease, using dynamic 31-phosphorus methods.
  
  
  METHODS
  32 patients with arterial occlusive disease were examined in a 1.5 T apparatus with a 6 cm surface coil before and after treatment. The metabolic changes in the quadriceps muscles were visualised during a 36 s phosphorus spectrum during rest, exercise (isometric and isotonic) and during a period of recovery.
  
  
  RESULTS
  Vascular therapy resulted in a significant increase in the duration of both types of exercise during dynamic phosphorus spectroscopy (isometric exercise: 282 s against 199 s: p = 0.002, isotonic exercise: 575 s against 222 s; p = 5 x 10(-6). After treatment, exercise-induced changes in pH (7.00 against 6.94; p = 0.004 and 7.00 against 6.93; p = 0.02) and the ratio Pi/PCr (0.34 against 0.44; p = 0.002 and 0.36 against 0.50; p = 0.009) were significantly smaller than before therapy, using a similar amount of exercise. Recovery time of Pi/PCr (45 s against 82 s; P = 10(-5) and 42 s against 57 s; p = 0.01) and pH value (154 s against 181 s; p = 0.14 and 173 s against 214 s; p = 0.22) showed significant reduction after treatment.
  
  
  CONCLUSIONS
  Dynamic 31-phosphorus magnetic resonance spectroscopy indicates increased mitochondrial oxidative capacity in the quadriceps muscles as evidence for increased oxygen supply to muscle tissue following vascular therapy.
authors.affiliation: Klinik und Poliklinik für Radiologie, Johannes Gutenberg-Universität Mainz.
authors.forename: K
authors.initials: K
authors.lastname: Schunk
authors.forename: B
authors.initials: B
authors.lastname: Romaneehsen
authors.forename: M
authors.initials: M
authors.lastname: Dahm
authors.forename: U
authors.initials: U
authors.lastname: Dietz
authors.forename: W
authors.initials: W
authors.lastname: Kersjes
authors.forename: S
authors.initials: S
authors.lastname: Schadmand-Fischer
authors.forename: C
authors.initials: C
authors.lastname: Düber
authors.forename: M
authors.initials: M
authors.lastname: Thelen
mesh_terms: D001157:Arterial Occlusive Diseases / Q000378:metabolism* / Q000628:therapy; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D009682:Magnetic Resonance Spectroscopy / Q000295:instrumentation / Q000379:methods; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000098:blood supply / Q000378:metabolism*; D010388:Pelvis / Q000098:blood supply*; D018709:Statistics, Nonparametric