title: Nephrotoxicity in goats caused by dosing with a water extract from the stems of Narthecium ossifragum plants.
abstract: Seven goats were given a single dose of an aqueous extract derived from 30 g (wet weight) of Narthecium ossifragum per kg liveweight. Their serum creatinine and urea concentrations increased to day 5 but then fell to normal by day 10. Serum magnesium increased to day 4 and decreased to normal by day 9. Their serum calcium concentration was lower than normal on days 4, 5 and 6. Histopathological examination of the kidneys of goats killed or found dead 2, 4, 6, 8, 11 or 16 days after dosing revealed tubular epithelial cell degeneration and necrosis. Regeneration of the tubular epithelium and signs of interstitial fibroplast proliferation and fibrosis could be seen in animals killed on days 8, 11, 16 and 42. No signs of liver damage were observed in 3 goats dosed with the insoluble plant material from 40 g (wet weight) Narthecium ossifragum per kg liveweight. The total dose was divided into three doses, which were given intraruminally within 7 h. The activities of aspartate aminotransferase, gamma-glutamyltransferase and glutamate dehydrogenase remained within the normal range in all 10 goats after dosing.
authors.affiliation: Department of Reproduction and Forensic Medicine, Norwegian College of Veterinary Medicine, Oslo, Norway.
authors.forename: A
authors.initials: A
authors.lastname: Flåøyen
authors.forename: B
authors.initials: B
authors.lastname: Bratberg
authors.forename: A
authors.initials: A
authors.lastname: Frøslie
authors.forename: H
authors.initials: H
authors.lastname: Grønstøl
authors.forename: W
authors.initials: W
authors.lastname: Langseth
authors.forename: P G
authors.initials: PG
authors.lastname: Mantle
authors.forename: A
authors.initials: A
authors.lastname: von Krogh
mesh_terms: D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D002118:Calcium / Q000097:blood; D003404:Creatinine / Q000097:blood; D004305:Dose-Response Relationship, Drug; D004848:Epithelium / Q000187:drug effects / Q000473:pathology; D005969:Glutamate Dehydrogenase / Q000097:blood; D015511:Goat Diseases / Q000209:etiology*; D006041:Goats; D007668:Kidney / Q000187:drug effects* / Q000473:pathology / Q000503:physiopathology; D008099:Liver / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology; D008168:Lung / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology; D008274:Magnesium / Q000097:blood; D008297:Male; D009336:Necrosis; D010936:Plant Extracts / Q000032:analysis / Q000633:toxicity*; D010939:Plant Poisoning / Q000209:etiology / Q000662:veterinary*; D018547:Plant Stems / Q000737:chemistry*; D013997:Time Factors; D014508:Urea / Q000097:blood; D014867:Water; D005723:gamma-Glutamyltransferase / Q000097:blood
chemical_list: D010936:Plant Extracts; D014867:Water; D014508:Urea; D003404:Creatinine; D005969:Glutamate Dehydrogenase; D005723:gamma-Glutamyltransferase; D001219:Aspartate Aminotransferases; D008274:Magnesium; D002118:Calcium