title: Regulation and execution of meiosis in Drosophila males.
abstract: In this chapter we review the regulation and execution of the meiotic cell divisions in the context of the developmental program that comprises Drosophila spermatogenesis. Male germ line cells undergoing meiosis are readily identifiable and are of a size and abundance that makes this system well suited for morphological characterizations of cell division. Furthermore, a wide range of molecular genetic techniques are available, facilitating mechanistic investigations. We present an overview of key stages in spermatogenesis and, in particular, meiosis. We consider the pathways controlling entry into the meiotic divisions in the context of established cell cycle regulators as well as newly identified loci required for meiotic entry. We then review the assembly and function of both the meiotic spindle and the contractile ring. We conclude with a consideration of questions and problems that await further investigation.
authors.affiliation: Department of Molecular Biology and Oncology, University of Texas Southwestern Medical Center, Dallas 75235-9148, USA.
authors.forename: J
authors.initials: J
authors.lastname: Maines
authors.forename: S
authors.initials: S
authors.lastname: Wasserman
mesh_terms: D000818:Animals; D002453:Cell Cycle / Q000502:physiology; D002454:Cell Differentiation / Q000502:physiology; D002455:Cell Division / Q000502:physiology; D004330:Drosophila / Q000502:physiology*; D008297:Male; D008540:Meiosis / Q000502:physiology*; D009154:Mutation; D013091:Spermatogenesis / Q000502:physiology; D008941:Spindle Apparatus / Q000502:physiology