Molecular cloning and mapping of a human cDNA (PA2G4) that encodes a protein highly homologous to the mouse cell cycle protein p38-2G4.
We have identified a novel human gene with strong homology to the mouse Pa2g4 cell cycle gene. This novel gene (called PA2G4) belongs to a gene family with members in several chromosome regions: 3q24-q25, 6q22, 9q21, 12q13, 18q12, 20p12 and Xq25. A composite cDNA of 1697 nucleotides was isolated. The sequence of this cDNA predicts a protein of 394 amino acids. The deduced amino acid sequence of this human protein shows very strong homology to the mouse protein p38-2G4. The cDNA analyzed probably corresponds to a functional copy found at 12q13.
Lamartine
J
J
International Agency for Research on Cancer, Lyon, France.
Seri
M
M
Cinti
R
R
Heitzmann
F
F
Creaven
M
M
Radomski
N
N
Jost
E
E
Lenoir
G M
GM
Romeo
G
G
Sylla
B S
BS
D000818:Animals; D001483:Base Sequence; D015152:Blotting, Northern; D002453:Cell Cycle / Q000235:genetics*; D002871:Chromosome Banding; D002874:Chromosome Mapping; D002881:Chromosomes, Human, Pair 12; D002890:Chromosomes, Human, Pair 20; D002893:Chromosomes, Human, Pair 3; D002896:Chromosomes, Human, Pair 6; D002899:Chromosomes, Human, Pair 9; D003001:Cloning, Molecular; D018076:DNA, Complementary / Q000302:isolation & purification; D004268:DNA-Binding Proteins; D005260:Female; D006801:Humans; D007422:Intestines / Q000737:chemistry; D007962:Leukocytes / Q000737:chemistry; D008297:Male; D051379:Mice; D008969:Molecular Sequence Data; D009687:Nuclear Proteins / Q000235:genetics*; D010053:Ovary / Q000737:chemistry; D011467:Prostate / Q000737:chemistry; D011544:Pseudogenes; D012333:RNA, Messenger / Q000032:analysis; D016601:RNA-Binding Proteins; D017386:Sequence Homology, Amino Acid; D013154:Spleen / Q000737:chemistry; D013737:Testis / Q000737:chemistry; D014960:X Chromosome
D018076:DNA, Complementary; D004268:DNA-Binding Proteins; D009687:Nuclear Proteins; C095938:Pa2g4 protein, mouse; D012333:RNA, Messenger; D016601:RNA-Binding Proteins