title: Stereotactic radiosurgery of skull base meningiomas.
abstract: Between April 1992 and February 1996, 97 patients with skull base meningiomas were treated at our department. The age of these patients ranged from 10 to 80 years. The male/female ratio was 1/2. Fifty-three of these patients had primary open surgery for partial removal or recurrent growth and subsequent radiosurgical treatment. Radiosurgery was performed as a primary treatment in 44 patients. The mean tumor volume was 13.7 cm3 (range: 0.8-82 cm3). These tumor volumes could be covered by mean isodose volumes of 45% (range: 20-70%) and were treated by a mean dose of 13.8 Gy (range: 7-25 Gy) at the tumor border. Six patients underwent radiosurgery with a staged treatment protocol with 4.6-6 months interval. In 78 patients, a total of 102 follow-up scans were available. The remaining 19 patients have not been included in the post-radiosurgical evaluation since the observation time was either too short or the patients were lost for follow-up. The mean interval between gamma knife treatment and last follow-up scan was 18.5 months, with a range from 6 to 46 months. Follow-up imaging (CT, MRI or both) revealed a decreased volume of the tumor in 31 cases (40%). In 44 cases (56%), tumor progression was stopped, and in 3 cases (4%) increased tumor volumes could be observed. In 8 cases marked central tumor necrosis was seen. Neurological follow-up examinations in 76 patients showed a stable neurological status in 71%, ameliorated status in 24% and worsening in 5% of the patients.
authors.affiliation: Department of Neurosurgery, Karl Franzens University, Graz, Austria.
authors.forename: G
authors.initials: G
authors.lastname: Pendl
authors.forename: O
authors.initials: O
authors.lastname: Schröttner
authors.forename: S
authors.initials: S
authors.lastname: Eustacchio
authors.forename: K
authors.initials: K
authors.lastname: Feichtinger
authors.forename: J
authors.initials: J
authors.lastname: Ganz
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008579:Meningioma / Q000175:diagnosis / Q000601:surgery*; D008875:Middle Aged; D016634:Radiosurgery; D019292:Skull Base Neoplasms / Q000175:diagnosis / Q000601:surgery*; D014057:Tomography, X-Ray Computed