Controlling conditioning-related emesis in children undergoing bone marrow transplantation.
OBJECTIVE
To compare the efficacy of two antiemetic regimens, ondansetron alone versus perphenazine with diphenhydramine, on emesis control in children undergoing conditioning therapy for bone marrow transplantation (BMT).


METHODS
Single-center, prospective, open, randomized, crossover study.


METHODS
Pediatric BMT unit in an urban area in the northeastern United States.


METHODS
28 children, ages 4-17, undergoing BMT for a variety of underlying diseases.


METHODS
After randomization to one of the two antiemetic regimens, emesis control was evaluated during conditioning therapy. If a participant experienced more than five episodes of emesis during any 12-hour period, he or she was crossed over to the other antiemetic regimen. If emesis control still was not achieved, the participant was removed from the study and other medications were administered to control vomiting.


METHODS
Number of emetic episodes and incidence of side effects.


RESULTS
10 of 15 patients (67%) who received ondansetron experienced major emesis control (no more than two episodes) compared with 0 of 13 patients (0%) who received perphenazine with diphenhydramine (p = 0.044, Fisher exact test). Of those who crossed over to ondansetron after failure with perphenazine and diphenhydramine, 38% were able to achieve major emesis control.


CONCLUSIONS
Ondansetron offers superior antiemetic control over the combination of perphenazine and diphenhydramine for children undergoing high-dose chemotherapy with or without total body irradiation for BMT.


CONCLUSIONS
Oncology nurses must develop an understanding of the etiology of therapy-induced emesis and the mechanisms of action of the various classes of antiemetic agents designed to control it. Implementing documentation to describe events of emesis will help to tailor antiemetic therapy to a patient's specific situation. Further research is necessary to determine alternate strategies, including different combinations or sequences of antiemetics to provide optimum emetic control during acute and delayed phases of emesis. The higher cost of ondansetron therapy must be considered within the context of superior efficacy.
Mehta
N H
NH
Department of Nursing, Children's Hospital, Boston, MA, USA.
Reed
C M
CM
Kuhlman
C
C
Weinstein
H J
HJ
Parsons
S K
SK
D000293:Adolescent; D000932:Antiemetics / Q000627:therapeutic use*; D016026:Bone Marrow Transplantation; D002648:Child; D002675:Child, Preschool; D018592:Cross-Over Studies; D004155:Diphenhydramine / Q000627:therapeutic use*; D018492:Dopamine Antagonists / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D017294:Ondansetron / Q000627:therapeutic use*; D010546:Perphenazine / Q000627:therapeutic use*; D011446:Prospective Studies; D019172:Transplantation Conditioning / Q000009:adverse effects*; D014839:Vomiting / Q000209:etiology / Q000517:prevention & control*
D000932:Antiemetics; D018492:Dopamine Antagonists; D017294:Ondansetron; D004155:Diphenhydramine; D010546:Perphenazine