Intratumoral microdistribution of [131I]MB-1 in patients with B-cell lymphoma following radioimmunotherapy.
Intratumoral microdistribution of radiolabeled anti-CD37 murine monoclonal antibody, [131I]MB-1, in lymph nodes from five patients with non-Hodgkin's B-cell lymphoma following radioimmunotherapy were evaluated by microautoradiography and image analysis of macroautoradiographs. Microdistribution of radioactivity was highly heterogeneous: silver grain counts varied from 28-70 to 8-10 per 400 X field, and the coefficients of variations calculated by image analysis ranged between 42.5 and 79.3%. Variable radiation doses delivered could have contributed to the limited durability of tumor regression.
Brown
R S
RS
Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor 48109-0028, USA.
Kaminski
M S
MS
Fisher
S J
SJ
Chang
A E
AE
Wahl
R L
RL
D000911:Antibodies, Monoclonal / Q000493:pharmacokinetics*; D001345:Autoradiography; D017321:Clinical Trials, Phase I as Topic; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007150:Immunohistochemistry; D007457:Iodine Radioisotopes; D007553:Isotope Labeling; D008198:Lymph Nodes / Q000000981:diagnostic imaging / Q000473:pathology; D016393:Lymphoma, B-Cell / Q000378:metabolism* / Q000473:pathology / Q000628:therapy*; D016499:Radioimmunotherapy / Q000379:methods*; D011877:Radionuclide Imaging; D016622:Silver Staining
D000911:Antibodies, Monoclonal; D007457:Iodine Radioisotopes