Effects of DQ-2511, a novel prokinetic agent, on electrical activities of smooth muscle in the guinea pig stomach.
Electrophysiological experiments were carried out to investigate the prokinetic actions of DQ-2511 on isolated smooth muscle of the guinea pig stomach. DQ-2511 enhanced the myogenic gastric slow waves and cholinergic excitatory junction potential and reduced the frequency of slow waves and the nonadrenergic, noncholinergic, and nonnitrergic inhibitory junction potential, with no significant alteration of the resting membrane potential. The results suggest that the prokinetic actions of DQ-2511 involve excitatory actions directly on smooth muscle and indirectly on cholinergic transmission.
Imaeda
K
K
Department of Physiology, Nagoya City University Medical School, Nagoya, Japan. kimaeda@med.nagoya-cu.ac.jp
Hashitani
H
H
Xue
L
L
Yamamoto
Y
Y
Itoh
M
M
Suzuki
H
H
D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D001285:Atropine / Q000494:pharmacology; D001549:Benzamides / Q000494:pharmacology*; D006168:Guinea Pigs; D008297:Male; D008564:Membrane Potentials; D018727:Muscarinic Antagonists / Q000494:pharmacology; D009130:Muscle, Smooth / Q000187:drug effects* / Q000294:innervation / Q000502:physiology; D018408:Patch-Clamp Techniques; D013270:Stomach / Q000187:drug effects* / Q000294:innervation / Q000502:physiology
D000897:Anti-Ulcer Agents; D001549:Benzamides; D018727:Muscarinic Antagonists; C058308:ecabapide; D001285:Atropine