title: Aspirin-induced asthma as a risk factor for asthma mortality.
abstract: We have recently reported severe airway obstruction and bronchial hyperresponsiveness (BHR) in fatal asthma compared with patients without a history of near-fatal asthma. Based on these findings, we evaluated whether aspirin-induced asthma (AIA) is a risk factor for asthma mortality by analyzing pulmonary function and BHR. FEV1.0% and methacholine inhalation threshold were significantly lower in the fatal asthma group compared with the AIA and non-AIA groups. However, there were no significant differences between the AIA and non-AIA groups. Our results suggested that AIA is not a risk factor for asthma mortality if avoidance of aspirin and aspirin-like drugs is assured.
authors.affiliation: Second Department of Internal Medicine, Nagasaki University School of Medicine, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Matsuse
authors.forename: T
authors.initials: T
authors.lastname: Shimoda
authors.forename: N
authors.initials: N
authors.lastname: Matsuo
authors.forename: C
authors.initials: C
authors.lastname: Fukushima
authors.forename: A
authors.initials: A
authors.lastname: Takao
authors.forename: H
authors.initials: H
authors.lastname: Sakai
authors.forename: S
authors.initials: S
authors.lastname: Asai
authors.forename: S
authors.initials: S
authors.lastname: Kohno
mesh_terms: D000328:Adult; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D001241:Aspirin / Q000009:adverse effects*; D001249:Asthma / Q000139:chemically induced* / Q000401:mortality*; D016535:Bronchial Hyperreactivity / Q000139:chemically induced / Q000401:mortality; D001985:Bronchial Provocation Tests; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D008297:Male; D016210:Methacholine Chloride / Q000494:pharmacology; D008875:Middle Aged; D012130:Respiratory Hypersensitivity / Q000139:chemically induced / Q000401:mortality; D012307:Risk Factors; D012720:Severity of Illness Index; D012737:Sex Factors
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D016210:Methacholine Chloride; D001241:Aspirin