The herbal preparation abana protects against radiation-induced micronuclei in mouse bone marrow.
The induction of micronuclei was studied in mouse bone marrow treated or not with 5, 10 and 20 mg/kg b.wt. of abana (a herbal preparation) before exposure to 0-3 Gy of gamma-radiation. Whole-body irradiation of mice resulted in a dose-dependent increase in the frequency of micronuclei. Treatment of mice with various doses of abana before exposure to different doses of gamma-rays resulted in a significant reduction of the micronucleus frequency at all exposure doses. The highest decline in the frequencies of micronuclei was observed after administration of 20 mg/kg abana, where the frequency of micronuclei was approximately 4-fold less than that of the concurrent control. The PCE/NCE ratio was significantly higher in the drug-treated group compared to DDW + irradiated control and it was almost restored to normal level after administration of 20 mg/kg abana. Our results demonstrate that abana protects mice against radiation-induced micronucleus formation and radiation-induced decline in cell proliferation.
Jagetia
G C
GC
Department of Radiobiology, Kasturba Medical College, Manipal, India.
Aruna
R
R
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects* / Q000528:radiation effects* / Q000648:ultrastructure; D002455:Cell Division / Q000187:drug effects / Q000528:radiation effects; D005720:Gamma Rays / Q000009:adverse effects; D008297:Male; D051379:Mice; D048629:Micronuclei, Chromosome-Defective / Q000187:drug effects* / Q000528:radiation effects*; D015162:Micronucleus Tests; D008903:Minerals / Q000008:administration & dosage / Q000494:pharmacology*; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology*; D011837:Radiation-Protective Agents / Q000008:administration & dosage / Q000494:pharmacology*
D008903:Minerals; D010936:Plant Extracts; D011837:Radiation-Protective Agents; C064613:abana