title: Successful treatment of two brothers with congenital afibrinogenemia for splenic rupture using heat- and solvent detergent-treated fibrinogen concentrates.
abstract: OBJECTIVE
  This report describes life-threatening spontaneous splenic rupture in two brothers with congenital afibrinogenemia.
  
  
  METHODS
  Two brothers, aged 11 and 14 years, had intra-abdominal bleeding due to splenic rupture confirmed by ECHO ultrasonography and computed tomography scans.
  
  
  RESULTS
  Splenectomy was performed after administration of heat- and solvent-detergent treated fibrinogen concentrates.
  
  
  CONCLUSIONS
  Hemostatic treatment for splenic rupture using heat- and solvent detergent-treated fibrinogen concentrates was effective. Careful attention must be paid to the risk of splenic rupture during the growth spurt in physically active children with this rare coagulation disorder.
authors.affiliation: Department of Pediatrics, Nara Medical University, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Shima
authors.forename: I
authors.initials: I
authors.lastname: Tanaka
authors.forename: Y
authors.initials: Y
authors.lastname: Sawamoto
authors.forename: H
authors.initials: H
authors.lastname: Kanehiro
authors.forename: N
authors.initials: N
authors.lastname: Matsuo
authors.forename: A
authors.initials: A
authors.lastname: Nishimura
authors.forename: J C
authors.initials: JC
authors.lastname: Giddings
authors.forename: A
authors.initials: A
authors.lastname: Yoshioka
mesh_terms: D000293:Adolescent; D000347:Afibrinogenemia / Q000150:complications* / Q000235:genetics / Q000628:therapy*; D000925:Anticoagulants / Q000737:chemistry / Q000627:therapeutic use*; D002648:Child; D003902:Detergents; D005340:Fibrinogen / Q000737:chemistry / Q000627:therapeutic use*; D005500:Follow-Up Studies; D006358:Hot Temperature; D006801:Humans; D008297:Male; D012997:Solvents; D013161:Splenic Rupture / Q000000981:diagnostic imaging / Q000209:etiology / Q000628:therapy*; D014057:Tomography, X-Ray Computed
chemical_list: D000925:Anticoagulants; D003902:Detergents; D012997:Solvents; D005340:Fibrinogen