Neurotrophic activity of organosulfur compounds having a thioallyl group on cultured rat hippocampal neurons.
Several organosulfur compounds found in garlic extract promoted the survival of rat hippocampal neurons in vitro. From the analysis of structure-activity relationship, thioallyl group in these compounds is essential for the manifestation of neurotrophic activity. S-Allyl-L-cysteine (SAC), one of the organosulfur compounds having thioallyl group in garlic extract, also promoted the axonal branching of cultured neurons. These results suggest that thioallyl compounds make a unique group of neurotrophic factors.
Moriguchi
T
T
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo, Japan.
Matsuura
H
H
Kodera
Y
Y
Itakura
Y
Y
Katsuki
H
H
Saito
H
H
Nishiyama
N
N
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D003545:Cysteine / Q000031:analogs & derivatives / Q000502:physiology; D004622:Embryo, Mammalian; D005737:Garlic / Q000737:chemistry / Q000502:physiology; D006624:Hippocampus / Q000166:cytology / Q000187:drug effects*; D009414:Nerve Growth Factors / Q000502:physiology*; D009474:Neurons / Q000187:drug effects*; D010946:Plants, Medicinal; D051381:Rats; D017208:Rats, Wistar; D013455:Sulfur / Q000502:physiology*
D009414:Nerve Growth Factors; D013455:Sulfur; C006453:alliin; C065299:S-allylcysteine; D003545:Cysteine