[The blood concentration of flurenizid in patients with destructive pulmonary tuberculosis].
Some pharmacokinetic features of new capsulated and tableted antituberculous drug flurenizidum were studied microbiologically in 50 adult patients with advanced pulmonary tuberculosis. Flurenizidum in vitro shows high mycobacteriostatic activity: it suppresses growth of Mycobacteria tuberculosis H37Rv strain in concentration of 0.05 mkg/ml. Single doze of flurenizidum--0.3 and 0.6 g--provided mycobacteriostatic blood concentration for 6 and 12 hours respectively. Maximum concentrations of the drug (0.46 +/- 0.07) mkg/ml and (1.02 +/- 0.14) mkg/ml respectively were observed in 3 hours after administration.
Panasiuk
V O
VO
Mykhal'chuk
V I
VI
D000328:Adult; D000995:Antitubercular Agents / Q000008:administration & dosage / Q000097:blood*; D002214:Capsules; D002908:Chronic Disease; D004305:Dose-Response Relationship, Drug; D006571:Heterocyclic Compounds / Q000008:administration & dosage / Q000097:blood*; D006801:Humans; D008826:Microbial Sensitivity Tests / Q000379:methods; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D013607:Tablets; D013997:Time Factors; D014397:Tuberculosis, Pulmonary / Q000097:blood* / Q000188:drug therapy
D000995:Antitubercular Agents; D002214:Capsules; D006571:Heterocyclic Compounds; D013607:Tablets; C065925:flurenizid