Use of paper for treatment of a peripheral nerve trauma in the rat.
Reinnervation of the muscles and skin in the rat hindpaw was studied after transection and attempted repair of the sciatic nerve. Reconnecting the transected nerve with lens cleaning paper was at least as effective in rejoining the transected nerves as traditional microsurgical neurorraphy. Paper induced a slightly bigger fibrous scar around the site of transection than neurorraphy, but this scar did not cause impairment of functional recovery or excessive signs of neuropathic pain. We conclude that a paper graft can be used in restorative surgery of severed peripheral nerves.
Kauppila
T
T
Department of Physiology, University of Helsinki, Finland.
Jyväsjärvi
E
E
Murtomäki
S
S
Mansikka
H
H
Pertovaara
A
A
Virtanen
I
I
Liesi
P
P
D000818:Animals; D006614:Hindlimb / Q000294:innervation; D008297:Male; D018482:Muscle, Skeletal / Q000294:innervation*; D009416:Nerve Regeneration / Q000502:physiology*; D010209:Paper; D051381:Rats; D017208:Rats, Wistar; D012584:Sciatic Nerve / Q000293:injuries* / Q000601:surgery