title: Hemodynamic advantages of left atrial epinephrine administration in open heart operations.
abstract: BACKGROUND
  It is often necessary to administer a catecholamine to patients who have undergone cardiac operations. However, there are some potential disadvantages to using the central venous circulation, a routine route for catecholamine infusion. The advantages of the left atrial infusion of epinephrine were investigated in 21 patients.
  
  
  METHODS
  The first group received epinephrine through the central venous route (central venous group), and the second group received adrenaline through the left atrial route (left atrial group). Hemodynamic studies were performed in all patients before and after the infusions. Blood samples were also taken from the radial and pulmonary arteries to determine the epinephrine concentrations.
  
  
  RESULTS
  The average pulmonary arterial pressure and pulmonary vascular resistance were higher in the central venous group, whereas higher cardiac indices and average blood pressures were noted in the left atrial group (p < 0.05). There was a statistically significant difference in the epinephrine concentrations in the pulmonary arterial and radial arterial samples between the two groups.
  
  
  CONCLUSIONS
  We conclude that epinephrine infusion through the left atrial route is associated with greater hemodynamic advantages than infusion through the central venous route.
authors.affiliation: Department of Cardiovascular Surgery, Faculty of Medicine, University of Ankara, Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Aral
authors.forename: M
authors.initials: M
authors.lastname: Oğuz
authors.forename: H
authors.initials: H
authors.lastname: Ozberrak
authors.forename: Y
authors.initials: Y
authors.lastname: Batislam
authors.forename: T
authors.initials: T
authors.lastname: Corapçioğlu
authors.forename: N T
authors.initials: NT
authors.lastname: Eren
authors.forename: R
authors.initials: R
authors.lastname: Taşöz
authors.forename: H
authors.initials: H
authors.lastname: Akalin
mesh_terms: D000368:Aged; D006348:Cardiac Surgical Procedures; D001026:Coronary Artery Bypass; D004837:Epinephrine / Q000008:administration & dosage* / Q000097:blood / Q000494:pharmacology; D005260:Female; D006325:Heart Atria; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged
chemical_list: D004837:Epinephrine