title: Effect of gegen-tang on painful gynecomastia in patients with liver cirrhosis: a brief report.
abstract: Four patients with liver cirrhosis and complaining of painful gynecomastia were treated with oral administration of Gegen-Tang (TJ-1). Pain disappeared in 3 patients in one week, and in one patient in 4 weeks. The size of gynecomastia did not change significantly on mammography, but palpable induration diminished or disappeared. The patients had been treated with Chaihu (saiko) group drugs for liver diseases, and TJ-1 was used in combination with these drugs. Serum levels of estrogen, progesterone, testosterone, and other sex hormones did not change significantly after TJ-1 treatment. These results suggest that TJ-1 could be used for the painful gynecomastia that is occasionally seen in cirrhotic patients.
authors.affiliation: Department of Internal Medicine, Kanazawa University, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Motoo
authors.forename: H
authors.initials: H
authors.lastname: Taga
authors.forename: S B
authors.initials: SB
authors.lastname: Su
authors.forename: N
authors.initials: N
authors.lastname: Sawabu
mesh_terms: D000284:Administration, Oral; D000368:Aged; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D012739:Gonadal Steroid Hormones / Q000097:blood; D006177:Gynecomastia / Q000188:drug therapy* / Q000209:etiology*; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications*; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000188:drug therapy*; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D010946:Plants, Medicinal
chemical_list: D004365:Drugs, Chinese Herbal; D012739:Gonadal Steroid Hormones; D010936:Plant Extracts; C090831:kakkon-to