title: Mitomycin C primary trabeculectomy in primary glaucoma of white patients.
abstract: OBJECTIVE
  To evaluate the clinical outcome of eyes which underwent primary trabeculectomy with adjunctive mitomycin C (MMC) for primary glaucoma.
  
  
  METHODS
  A prospective analysis of 25 eyes in 23 patients who underwent primary trabeculectomy with MMC for primary glaucoma was performed. Clinical outcome measures including postoperative intraocular pressure, change in logarithm of the minimum angle of resolution (LogMAR) visual acuity, and incidence of complications were measured up to 1 year postoperatively.
  
  
  RESULTS
  Mean intraocular pressure decreased from 26.0 +/- 4.4 mmHg preoperatively to 12.5 +/- 3.9 mmHg (p < 0.0001) 1 year postoperatively. The mean LogMAR visual acuity changed from 0.23 +/- 0.19 preoperatively to 0.23 +/- 0.20 1 year postoperatively (p = 1.0). One eye developed a temporary hypotonous maculopathy and 4 eyes progressed in cataract formation.
  
  
  CONCLUSIONS
  Primary trabeculectomy with MMC in eyes with primary glaucoma showed excellent pressure reduction. There were no cases of persistent hypotonous maculopathy or bleb endophthalmitis.
authors.affiliation: Department of Ophthalmology, Academic Hospital Maastricht, Maastrich, The Netherlands.
authors.forename: R M
authors.initials: RM
authors.lastname: Nuijts
authors.forename: R C
authors.initials: RC
authors.lastname: Vernimmen
authors.forename: C A
authors.initials: CA
authors.lastname: Webers
mesh_terms: D000963:Antimetabolites / Q000627:therapeutic use*; D002386:Cataract / Q000209:etiology / Q000503:physiopathology; D018450:Disease Progression; D005901:Glaucoma / Q000188:drug therapy* / Q000208:ethnology / Q000601:surgery*; D006801:Humans; D007429:Intraocular Pressure; D007430:Intraoperative Care; D016685:Mitomycin / Q000627:therapeutic use*; D011183:Postoperative Complications; D011184:Postoperative Period; D011446:Prospective Studies; D012164:Retinal Diseases / Q000209:etiology; D014130:Trabeculectomy; D014792:Visual Acuity; D044465:White People
chemical_list: D000963:Antimetabolites; D016685:Mitomycin