title: Quick onset of severe abdominal pain after codeine in an ultrarapid metabolizer of debrisoquine.
abstract: The authors describe a 33-year-old woman who experienced severe pain in the epigastrium after codeine intake. This side-effect is consistent with that of morphine. Later, the patient was phenotyped and genotyped as an ultrarapid metabolizer with high capacity to metabolize codeine to morphine.
authors.affiliation: Department of Medical Laboratory Sciences & Technology, Huddinge University Hospital, Sweden.
authors.forename: P
authors.initials: P
authors.lastname: Dalén
authors.forename: C
authors.initials: C
authors.lastname: Frengell
authors.forename: M L
authors.initials: ML
authors.lastname: Dahl
authors.forename: F
authors.initials: F
authors.lastname: Sjöqvist
mesh_terms: D015746:Abdominal Pain / Q000139:chemically induced* / Q000378:metabolism; D000328:Adult; D000701:Analgesics, Opioid / Q000009:adverse effects* / Q000378:metabolism; D003061:Codeine / Q000009:adverse effects* / Q000378:metabolism*; D019389:Cytochrome P-450 CYP2D6 / Q000378:metabolism*; D003647:Debrisoquin / Q000378:metabolism; D005260:Female; D006801:Humans
chemical_list: D000701:Analgesics, Opioid; D019389:Cytochrome P-450 CYP2D6; D003061:Codeine; D003647:Debrisoquin