title: How valid is emergency liver transplantation for acute liver necrosis in patients with multiple-organ failure?
abstract: Multiple-organ failure (MOF), defined as the failure of initially uninvolved organs, is the final step of definitive and massive liver necrosis. Emergency liver transplantation (ELT) has radically modified the outcome of acute liver failure and early primary graft failure, but the results of ELT in cases of MOF are unknown. From May 1988 to June 1993, 243 patients underwent a liver transplantation (LT). Thirty-seven patients (15.2%) who had an acute liver necrosis complicated by a MOF underwent an ELT. Twenty-one patients were children. An emergency retransplantation was performed in 16 patients. Three or 4 organ-system failures (OSF) were present in 13 patients. Before ELT, the mean Acute Physiology and Chronic Health Evaluation (APACHE) II score was 26.3 +/- 5.1. Six-month and 1-year survival rates were 37.8% and 25.9%, respectively, after ELT complicated by MOF, and 78% and 73.5%, respectively, in other cases of LT. Twenty-six patients had surgical complications (70%), whereas thirty-one patients had medical complications (84%). Twenty-two patients died during the postoperative period (60%). Before ELT, infection (P < .05), cardiovascular failure (P < .03), and more than two OSF (P < .05) were more frequent in patients who died after intervention. The APACHE II score (P < .05) and the length of stay in the intensive care unit before ELT (P < .05) were lower among survivors. In the context of liver allograft shortage, our results suggest that an ELT should not be performed in patients with cardiac failure, more than two OSF, or an APACHE II score higher than 30.
authors.affiliation: Clinique Chirurgicale, Hôpital Cochin, Paris, France.
authors.forename: J
authors.initials: J
authors.lastname: Pitre
authors.forename: O
authors.initials: O
authors.lastname: Soubrane
authors.forename: B
authors.initials: B
authors.lastname: Dousset
authors.forename: Y
authors.initials: Y
authors.lastname: Ozier
authors.forename: F
authors.initials: F
authors.lastname: Baudin
authors.forename: D
authors.initials: D
authors.lastname: Devictor
authors.forename: O
authors.initials: O
authors.lastname: Bernard
authors.forename: D
authors.initials: D
authors.lastname: Houssin
authors.forename: Y
authors.initials: Y
authors.lastname: Chapuis
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D004630:Emergencies; D005260:Female; D006801:Humans; D007223:Infant; D008099:Liver / Q000473:pathology*; D016031:Liver Transplantation / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000601:surgery*; D009336:Necrosis; D012189:Retrospective Studies; D016896:Treatment Outcome