Human immunodeficiency virus type 2 envelope glycoprotein binds to CD8 as well as to CD4 molecules on human T cells.
We report here that human immunodeficiency virus type 2 (HIV-2) envelope glycoprotein (gp105), but not HIV-1 gp120, can bind to CD8 molecules as well as to CD4 molecules on human T cells. This phenomenon may lead to differences in the life cycles of HIV-1 and HIV-2, and it may be related to the differences in disease manifestations of HIV-1 and HIV-2 infection, including longer survival of HIV-2-infected patients.
Kaneko
H
H
Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan.
Neoh
L P
LP
Takeda
N
N
Akimoto
H
H
Hishikawa
T
T
Hashimoto
H
H
Hirose
S
S
Karaki
S
S
Takiguchi
M
M
Nakauchi
H
H
Kaneko
Y
Y
Yamamoto
N
N
Sekigawa
I
I
D015704:CD4 Antigens / Q000378:metabolism*; D015496:CD4-Positive T-Lymphocytes / Q000821:virology*; D016827:CD8 Antigens / Q000378:metabolism*; D018414:CD8-Positive T-Lymphocytes / Q000821:virology*; D002460:Cell Line; D015686:Gene Products, env / Q000378:metabolism*; D015699:HIV Envelope Protein gp120 / Q000378:metabolism; D015498:HIV-2 / Q000378:metabolism*; D006801:Humans; D011485:Protein Binding; D015728:Receptors, HIV / Q000378:metabolism*; D054299:env Gene Products, Human Immunodeficiency Virus
D015704:CD4 Antigens; D016827:CD8 Antigens; D015686:Gene Products, env; D015699:HIV Envelope Protein gp120; D015728:Receptors, HIV; D054299:env Gene Products, Human Immunodeficiency Virus; C069790:gp105 envelope protein, Human immunodeficiency virus 2