Purification of a factor that enhances the antibacterial activity of beta-lactams against methicillin-resistant Staphylococcus aureus: its identification as undecaphosphotungstate.
Previously, a factor (Factor T) was found in aged mixtures of tungstate and phosphate, which greatly enhances the antibacterial effects of beta-lactam antibiotics on methicillin-resistant Staphylococcus aureus. Factor T was purified and identified as undecaphosphotungstate ([PW11O39]7-). Undecasilicotungstate ([SiW11O39]8-), a compound closely related to undecaphosphotungstate, showed a similar enhancing effect.
Tajima
Y
Y
Chemical Assay Center, Nabeshima, Saga, Japan.
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004357:Drug Synergism; D016106:Methicillin Resistance; D008826:Microbial Sensitivity Tests; D017553:Phosphorus Compounds / Q000302:isolation & purification* / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000502:physiology; D017973:Tungsten Compounds / Q000302:isolation & purification* / Q000494:pharmacology*; D047090:beta-Lactams
D000900:Anti-Bacterial Agents; D017553:Phosphorus Compounds; D017973:Tungsten Compounds; D047090:beta-Lactams; C108976:undecaphosphotungstate