title: A region of allelic imbalance in 1q31-32 in primary breast cancer coincides with a recombination hot spot.
abstract: Previous studies have shown that the 1q31-32 region frequently presents allelic imbalance (AI) in various neoplastic diseases, such as breast cancer, medulloblastoma, male germ cell tumors, and renal collecting duct carcinoma, suggesting the presence of a tumor suppressor gene in this location. We used 19 informative microsatellite markers to analyze 33 primary breast tumors for AI in the 1q31-32 region. Our results demonstrate a 10-cM critical region of AI that is present in more than 60% of the tumors. This region is located proximal to the REN locus and is flanked by the CACNL1A3 and D1S2655 markers. Most important, the critical region of AI coincides with a female hot spot of recombination, suggesting a possible correlation between the two regions.
authors.affiliation: Departamento Genética, Fundación Jimenez Díaz, Madrid, Spain. fjdvgenetica@jet.es
authors.forename: J
authors.initials: J
authors.lastname: Benítez
authors.forename: A
authors.initials: A
authors.lastname: Osorio
authors.forename: A
authors.initials: A
authors.lastname: Barroso
authors.forename: E
authors.initials: E
authors.lastname: Arranz
authors.forename: M A
authors.initials: MA
authors.lastname: Díaz-Guillén
authors.forename: M
authors.initials: M
authors.lastname: Robledo
authors.forename: S
authors.initials: S
authors.lastname: Rodríguez de Córdoba
authors.forename: D
authors.initials: D
authors.lastname: Heine-Suñer
mesh_terms: D000483:Alleles; D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology; D018270:Carcinoma, Ductal, Breast / Q000235:genetics; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics*; D018450:Disease Progression; D005260:Female; D016147:Genes, Tumor Suppressor; D005819:Genetic Markers; D006801:Humans; D019656:Loss of Heterozygosity; D008297:Male; D018895:Microsatellite Repeats; D011995:Recombination, Genetic; D012727:Sex Characteristics
chemical_list: D005819:Genetic Markers