The influence of gamma irradiation on the physicochemical properties of a novel triblock copolymer of epsilon-caprolactone and ethylene oxide.
A novel triblock copolymer of epsilon-caprolactone (CL) and ethylene oxide (E), CL6E90CL6, intended for use in implantable drug-delivery systems, has been subjected to gamma irradiation, in the solid state and in aqueous solution, under different controlled environmental conditions, to assess its stability to a radiation sterilization process. When copolymer matrices were irradiated with doses of irradiation up to 72 kGy in the presence of oxygen, negligible changes were observed in the molar mass, molecular mobility (assessed by pulsed nuclear magnetic resonance spectroscopy) and thermal properties. However, irradiation of matrices in the absence of oxygen (anoxia) induced the formation of cross-links, as indicated by a reduction in the molecular mobility of the copolymer, but without affecting its molar mass and thermal properties. Gamma irradiation of aqueous solutions of CL6E90CL6 in the presence of oxygen induced random polymer chain scission, as evidenced by a reduction in the molar mass, and the formation of a distribution of copolymer chain lengths in solution. Nuclear magnetic resonance relaxation studies showed that irradiation of solutions of CL6E90CL6 at concentrations greater than 4% w/v under anoxic conditions with doses of 54 kGy produced polymer gels with a network structure. These differences in the effects of gamma irradiation on the physicochemical properties of CL6E90CL6 might be germane to the method selected for sterilization of the polymer before its use in implantable drug-delivery systems.
Martini
L
L
School of Pharmacy and Pharmaceutical Sciences, University of Manchester, UK.
Collett
J H
JH
Attwood
D
D
D016503:Drug Delivery Systems; D004343:Drug Implants; D005027:Ethylene Oxide; D005720:Gamma Rays; D010100:Oxygen / Q000494:pharmacology; D011108:Polymers / Q000528:radiation effects*
D004343:Drug Implants; D011108:Polymers; D005027:Ethylene Oxide; D010100:Oxygen