title: Robert Feulgen Lecture 1997. Lipid microdomains and membrane trafficking in mammalian cells.
abstract: This overview summarizes the data for how epithelial cells sort and deliver proteins and lipids to the apical and basolateral cell surface domains. The basolateral pathway uses a Rab-SNARE mechanism for docking and fusion, while the apical route employs a different machinery. This latter mechanism is based on lipid microdomains, composed of clusters of sphingolipids and cholesterol, which function as rafts for apical delivery. The sphingolipid-cholesterol raft mechanism seems to be employed generally by mammalian cells to transport raft-associated proteins to their post-Golgi destinations.
authors.affiliation: European Molecular Biology Laboratory, Cell Biology Programme, Heidelburg, Germany.
authors.forename: P
authors.initials: P
authors.lastname: Verkade
authors.forename: K
authors.initials: K
authors.lastname: Simons
mesh_terms: D000818:Animals; D001692:Biological Transport; D002462:Cell Membrane / Q000378:metabolism*; D004705:Endocytosis / Q000502:physiology; D004848:Epithelium / Q000378:metabolism; D006801:Humans; D050356:Lipid Metabolism; D008055:Lipids / Q000502:physiology; D008565:Membrane Proteins / Q000378:metabolism* / Q000502:physiology; D011506:Proteins / Q000378:metabolism; D050600:SNARE Proteins; D033921:Vesicular Transport Proteins
chemical_list: D008055:Lipids; D008565:Membrane Proteins; D011506:Proteins; D050600:SNARE Proteins; D033921:Vesicular Transport Proteins