title: The effects of reflex parasympathetic stimulation on the QT interval and QT dispersion.
abstract: The effect of phenylephrine-induced reflex parasympathetic stimulation on QT interval and its dispersion was studied in 16 healthy subjects with a history of paroxysmal supraventricular tachycardia, both during sinus rhythm and during atrial pacing. Results demonstrate that rapid reflex parasympathetic stimulation does not influence QT interval duration or QT dispersion, and also emphasize the inappropriateness of Bazett's formula, the need for comparison of QT intervals during identical heart rates, and the importance of analyzing all 12 leads of a standard electrocardiogram when assessing the effects of various interventions on the QT interval.
authors.affiliation: Department of Cardiological Sciences, St. George's Hospital Medical School, London, United Kingdom.
authors.forename: J
authors.initials: J
authors.lastname: Kautzner
authors.forename: J E
authors.initials: JE
authors.lastname: Hartikainen
authors.forename: S
authors.initials: S
authors.lastname: Heald
authors.forename: A J
authors.initials: AJ
authors.lastname: Camm
authors.forename: M
authors.initials: M
authors.lastname: Malik
mesh_terms: D000328:Adult; D004562:Electrocardiography / Q000187:drug effects*; D005260:Female; D006321:Heart / Q000294:innervation*; D006801:Humans; D008297:Male; D010275:Parasympathetic Nervous System / Q000187:drug effects*; D010656:Phenylephrine; D012018:Reflex / Q000187:drug effects*; D012815:Signal Processing, Computer-Assisted; D013566:Sympathomimetics
chemical_list: D013566:Sympathomimetics; D010656:Phenylephrine