P53 auto-antibodies in the sera of patients with oral squamous cell carcinoma.
OBJECTIVE
To investigate the sera of patients with oral squamous cell carcinoma (OSCC) for the existence of p53 auto-antibodies.


METHODS
The sera of thirty-nine OSCC-patients were investigated. All samples were from untreated patients with no history of another neoplastic disease. The sera of nine healthy subjects served as controls.


RESULTS
P53 auto-antibodies were not detected both in all healthy subjects and in 20.6% OSCC-patients with their disease at an advanced stage. We prove that the extinction rates for p53 auto-antibodies in OSCC are very weak in the majority of investigated sera (50%) and are not related to tumour stage.


CONCLUSIONS
It is unlikely that p53 auto-antibodies can serve as a prognostic marker of OSCC.
Friedrich
R E
RE
Department of Oral and Maxillofacial Surgery, Eppendorf University Hospital, University of Hamburg, Germany.
Bartel-Friedrich
S
S
Plambeck
K
K
Bahlo
M
M
Klapdor
R
R
D001323:Autoantibodies / Q000097:blood*; D002294:Carcinoma, Squamous Cell / Q000097:blood*; D006801:Humans; D009062:Mouth Neoplasms / Q000097:blood*; D011379:Prognosis; D016159:Tumor Suppressor Protein p53 / Q000276:immunology*
D001323:Autoantibodies; D016159:Tumor Suppressor Protein p53