title: Taming TNF: strategies to restrain this proinflammatory cytokine.
abstract: Recent studies have demonstrated the essential role of tumor necrosis factor alpha (TNF-alpha) in rheumatoid arthritis and Crohn's disease. This article discusses agents known to suppress the formation or activity of TNF-alpha, and summarizes clinical studies using anti-TNF-alpha antibodies.
authors.affiliation: Medizinische Klinik, Klinikum Innenstadt der Ludwig-Maximilians-Universität, München, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Eigler
authors.forename: B
authors.initials: B
authors.lastname: Sinha
authors.forename: G
authors.initials: G
authors.lastname: Hartmann
authors.forename: S
authors.initials: S
authors.lastname: Endres
mesh_terms: D000818:Animals; D000906:Antibodies / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000276:immunology / Q000628:therapy; D003424:Crohn Disease / Q000276:immunology / Q000628:therapy; D006801:Humans; D018836:Inflammation Mediators / Q000037:antagonists & inhibitors* / Q000502:physiology; D010726:Phosphodiesterase Inhibitors / Q000494:pharmacology; D018805:Sepsis / Q000276:immunology / Q000628:therapy; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors* / Q000502:physiology
chemical_list: D000906:Antibodies; D018836:Inflammation Mediators; D010726:Phosphodiesterase Inhibitors; D014409:Tumor Necrosis Factor-alpha