Features and prognosis of exertional syncope in light-chain associated AL cardiac amyloidosis.
Syncope is common in AL amyloid heart disease and in almost 1/3 of our patients who experienced syncope, it was precipitated by physiologic stress. Stress-precipitated syncope was associated with a poor prognosis in such patients, both in terms of their median survival of 2 months and was frequently a precursor of sudden cardiac death.
Chamarthi
B
B
Section of Cardiology and the Arthritis Research Center, Boston University School of Medicine, Massachusetts, USA.
Dubrey
S W
SW
Cha
K
K
Skinner
M
M
Falk
R H
RH
D000686:Amyloidosis / Q000150:complications* / Q000503:physiopathology; D009202:Cardiomyopathies / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology; D016757:Death, Sudden, Cardiac / Q000209:etiology; D004562:Electrocardiography; D015444:Exercise; D005080:Exercise Test; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D013312:Stress, Physiological / Q000150:complications; D013575:Syncope / Q000209:etiology* / Q000503:physiopathology; D019462:Syncope, Vasovagal / Q000209:etiology / Q000503:physiopathology