Effect of locust poison on neuromembrane functional activity.
1. The effect of locust poison (LP) on membrane excitability, chemosensitivity and Na-K pump activity was studied. 2. LP in a concentration of 10(-4) mg/ml has a potential independent blocking effect on neuromembrane excitability. 3. LP has an activation effect on Na-K pump-induced membrane hyperpolarization. 4. In a concentration higher than 10(-4) mg/ml, LP leads to a decrease in the acetylcholine-induced current and to an increase in this current after the washout of LP from the medium.
Saghyan
A
A
Biophysics Center, Armenian NAS, Yerevan, Armenia.
Hunanian
A
A
Ayrapetyan
S
S
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D006110:Grasshoppers; D006372:Helix, Snails; D066298:In Vitro Techniques; D008564:Membrane Potentials / Q000187:drug effects; D009474:Neurons / Q000187:drug effects*; D009498:Neurotoxins / Q000494:pharmacology*; D018408:Patch-Clamp Techniques; D011042:Poisons / Q000494:pharmacology*; D000254:Sodium-Potassium-Exchanging ATPase / Q000187:drug effects*
D009498:Neurotoxins; D011042:Poisons; D000254:Sodium-Potassium-Exchanging ATPase; D000109:Acetylcholine