title: Treatment of relapsing-remitting multiple sclerosis with natural interferon beta: a multicenter, randomized clinical trial.
abstract: Preliminary results of a multicenter, randomized study on the effect of natural interferon beta (n-INFN-beta) in relapsing-remitting MS are reported. Sixty patients received either no treatment or n-IFN-beta (9 MIU three times a week, subcutaneously). After 6 months, the n-IFN-beta-treated group showed a 58% median reduction in the number of active lesions detected on monthly magnetic resonance imaging scans as well as a 38% reduction in the exacerbation rate as compared with the control group. Side-effects were mild and self-limiting. The study continues according to the protocol.
authors.affiliation: Department of Neurology, Hospital Carlos Haya, Malaga, Spain.
authors.forename: O
authors.initials: O
authors.lastname: Fernández
authors.forename: A
authors.initials: A
authors.lastname: Antiquëdad
authors.forename: T
authors.initials: T
authors.lastname: Arbizu
authors.forename: A
authors.initials: A
authors.lastname: Capdevíla
authors.forename: P
authors.initials: P
authors.lastname: de Castro
authors.forename: J C
authors.initials: JC
authors.lastname: Correa de Sa
authors.forename: J A
authors.initials: JA
authors.lastname: García-Merino
authors.forename: G
authors.initials: G
authors.lastname: Izquierdo
authors.forename: A
authors.initials: A
authors.lastname: Magalhaes
authors.forename: X
authors.initials: X
authors.lastname: Montalbán
mesh_terms: D000276:Adjuvants, Immunologic / Q000008:administration & dosage*; D000293:Adolescent; D000328:Adult; D006801:Humans; D016899:Interferon-beta / Q000008:administration & dosage*; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000175:diagnosis / Q000628:therapy*; D012008:Recurrence
chemical_list: D000276:Adjuvants, Immunologic; D016899:Interferon-beta