title: Regulation of ion transport by protein-protein interaction domains.
abstract: Protein-protein interaction via specific modular domains has been implicated in the regulation of many signalling pathways. Recently, such modules, in particular WW, Src homology-3 and PDZ domains, have been shown to regulate localization, clustering and function of several ion channels and transporters, including the epithelial Na+ channel, K+ channel and ionotropic neurotransmitter receptors.
authors.affiliation: Hospital for Sick Children, Division of Respiratory Research, Toronto, Ontario, Canada.
authors.forename: O
authors.initials: O
authors.lastname: Staub
authors.forename: D
authors.initials: D
authors.lastname: Rotin
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D006801:Humans; D007473:Ion Channels / Q000378:metabolism*; D017136:Ion Transport; D008969:Molecular Sequence Data; D011485:Protein Binding; D011506:Proteins / Q000737:chemistry / Q000378:metabolism*
chemical_list: D007473:Ion Channels; D011506:Proteins