title: Nasal provocation tests in the diagnosis of urticaria induced by acetylsalicylic acid.
abstract: Nasal provocation tests with lysine acetylsalicylic acid (ASA) have been used in the diagnosis of ASA-induced asthma and rhinitis. To establish its possible role in identifying aspirin sensitivity manifested by urticaria or angioedema, 18 patients suffering from chronic or acute recurring urticaria/angioedema (10 ASA-sensitive and 8 ASA-nonsensitive) were submitted to nasal provocation tests with freshly prepared solutions of lysine ASA. Clinical response and variation of nasal expiratory peak-flow were evaluated, classified according to previously defined scores, and compared. The results showed a significant difference between ASA-sensitive and ASA-nonsensitive patients, suggesting that this test can be an important diagnostic tool for ASA-induced urticaria/angioedema.
authors.affiliation: I Medical Clinic, University Hospital Santa Maria, Lisboa, Portugal.
authors.forename: E M
authors.initials: EM
authors.lastname: Tomaz
authors.forename: M F
authors.initials: MF
authors.lastname: Ferreira
authors.forename: M A
authors.initials: MA
authors.lastname: Spínola
authors.forename: M L
authors.initials: ML
authors.lastname: Oliveira
authors.forename: M H
authors.initials: MH
authors.lastname: Clode
authors.forename: A G
authors.initials: AG
authors.lastname: Palma-Carlos
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D001241:Aspirin / Q000009:adverse effects* / Q000031:analogs & derivatives*; D005260:Female; D006801:Humans; D008239:Lysine / Q000031:analogs & derivatives*; D008297:Male; D008875:Middle Aged; D009299:Nasal Provocation Tests; D012680:Sensitivity and Specificity; D014581:Urticaria / Q000139:chemically induced / Q000175:diagnosis*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D008239:Lysine; D001241:Aspirin; C010395:acetylsalicylic acid lysinate