Assignment of the possible HTLV receptor gene to chromosome 17q21-q23.
We have determined the HTLV (Human T-cell leukemia virus) receptor localization more precisely on the human chromosome 17. Based on the fact that HTLV infection induces syncytium formation of infected cells as a result of interaction between the viral envelope and viral receptor, we performed the sensitive biological assay using recombinant vaccinia expression system. Our results from the induced syncytium pattern of the somatic hybrid cell lines with different deletions indicated that the HTLV receptor gene may reside from q21 to q23 on the long arm of the human chromosome 17.
Tajima
Y
Y
Department of Neurology, Hokkaido University School of Medicine, Sapporo, Japan.
Tashiro
K
K
Camerini
D
D
D000818:Animals; D002460:Cell Line; D002874:Chromosome Mapping; D002886:Chromosomes, Human, Pair 17 / Q000737:chemistry* / Q000378:metabolism; D015368:Human T-lymphotropic virus 1 / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D006822:Hybrid Cells; D051379:Mice; D011991:Receptors, Virus / Q000737:chemistry / Q000235:genetics*
C080823:HTLV-I receptor; D011991:Receptors, Virus