Central serotonergic system and mechanism of anxiolytic action.
The results clearly indicate that the hippocampus, rather than nucleus accumbens is involved in mediating anxiolytic-like effects of the 5-HT1A receptor agonists. Furthermore, hippocampal postsynaptic 5-HT1A receptors may account for the anti-emotional influence of this groups of drugs. As far as the 5-HT3 receptor antagonists are concerned, it was more difficult to localize their central anti-anxiety like action. More clear and unequirocal effects could be observed after intra-accumbens, rather than after intrahippocampal injections of tropisetron and ondansetron.
Plaznik
A
A
Department of Pharmacology and Physiology of the Nervous System, Institute of Psychiatry and Neurology, Warsaw, Poland.
Stefański
R
R
Jessa
M
M
Nazar
M
M
Bidziński
A
A
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D003220:Conflict, Psychological; D004597:Electroshock; D006624:Hippocampus / Q000187:drug effects; D009043:Motor Activity / Q000187:drug effects; D009714:Nucleus Accumbens / Q000187:drug effects; D051381:Rats; D012701:Serotonin / Q000502:physiology*; D012702:Serotonin Antagonists / Q000494:pharmacology; D017366:Serotonin Receptor Agonists / Q000494:pharmacology
D014151:Anti-Anxiety Agents; D012702:Serotonin Antagonists; D017366:Serotonin Receptor Agonists; D012701:Serotonin