title: Application of HLA class II polymorphism analysis to the study of the population structure of the Island of Krk, Croatia.
abstract: The population structure of the northern Adriatic island of Krk, Croatia, was studied using PCR methodology and nonradioactive oligonucleotide hybridization for the analysis of HLA-DRB1, DRB3, DRB4, DRB5, DQA1, and DQB1 polymorphisms. Allele frequencies, genetic kinship (R), and genetic distances (E2) were computed, and correlations between distance (genetic, linguistic, geographic) and kinship (migration) matrices were examined. The results, reflecting past (micro-) evolutionary processes, indicate that ethnohistorical and sociocultural events rather than geographic distances are the primary determinants of today's population structure of the island.
authors.affiliation: Institute for Anthropological Research, Zagreb, Croatia.
authors.forename: I
authors.initials: I
authors.lastname: Martinović
authors.forename: M
authors.initials: M
authors.lastname: Bakran
authors.forename: A
authors.initials: A
authors.lastname: Chaventré
authors.forename: B
authors.initials: B
authors.lastname: Janićijević
authors.forename: V
authors.initials: V
authors.lastname: Jovanović
authors.forename: N
authors.initials: N
authors.lastname: Smolej-Narancić
authors.forename: A
authors.initials: A
authors.lastname: Kastelan
authors.forename: Z
authors.initials: Z
authors.lastname: Grubić
authors.forename: R
authors.initials: R
authors.lastname: Zunec
authors.forename: D F
authors.initials: DF
authors.lastname: Roberts
authors.forename: P
authors.initials: P
authors.lastname: Rudan
mesh_terms: D000328:Adult; D000883:Anthropology; D017523:Croatia; D004247:DNA / Q000032:analysis*; D005260:Female; D005828:Genetics, Population; D006683:HLA-DQ Antigens / Q000235:genetics*; D006684:HLA-DR Antigens / Q000235:genetics*; D006801:Humans; D016013:Likelihood Functions; D008297:Male
chemical_list: D006683:HLA-DQ Antigens; D006684:HLA-DR Antigens; D004247:DNA