title: Relationships between neuropsychological and oculomotor measures in schizophrenia patients and normal controls.
abstract: Establishing the relationship between oculomotor and neuropsychological impairments might facilitate a more coherent description of schizophrenia-associated neurocognitive deficits. Therefore, we assessed several aspects of neuropsychological and oculomotor function in 25 medicated schizophrenia patients and 24 age-matched controls. Neuropsychological tasks included the Wisconsin Cart Sort Test (WCST), the Trail Making Test (TMT), the Rey Auditory Verbal Learning Test, and finger tapping speed. Oculomotor functions assessed included smooth pursuit, initiation of smooth pursuit, predictive pursuit, fixation, visually guided saccades, remembered saccades, and antisaccades. Among the schizophrenia patients, predictive pursuit performance correlated significantly with finger tapping (dominant hand), TMT (both parts), and one WCST measure (categories completed). The only other significant correlation among the schizophrenia patients was between antisaccade performance and part A of the TMT. Perseverative errors during the WCST and antisaccade performance were the only measures significantly correlated among the normals. Closely related neurocognitive deficits may be responsible for impairments in TMT, WCST, predictive pursuit, and antisaccade performance in schizophrenia.
authors.affiliation: Psychopharmacology Laboratory, Harborview Medical Center, University of Washington, Seattle, USA.
authors.forename: A D
authors.initials: AD
authors.lastname: Radant
authors.forename: K
authors.initials: K
authors.lastname: Claypoole
authors.forename: D K
authors.initials: DK
authors.lastname: Wingerson
authors.forename: D S
authors.initials: DS
authors.lastname: Cowley
authors.forename: P P
authors.initials: PP
authors.lastname: Roy-Byrne
mesh_terms: D000328:Adult; D001288:Attention / Q000502:physiology; D004585:Electrooculography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests / Q000706:statistics & numerical data*; D015835:Ocular Motility Disorders / Q000175:diagnosis* / Q000503:physiopathology; D011594:Psychometrics; D011698:Pursuit, Smooth / Q000502:physiology*; D011930:Reaction Time / Q000502:physiology; D012016:Reference Values; D015203:Reproducibility of Results; D012438:Saccades / Q000502:physiology*; D012559:Schizophrenia / Q000175:diagnosis* / Q000503:physiopathology; D012815:Signal Processing, Computer-Assisted