Anti-Legionella activity of trovafloxacin compared with seven other antimicrobial agents including an intermethod evaluation.
The activity of trovafloxacin, a new fluorinated naphtheridone, was tested against 61 Legionella spp. isolates and compared with that of 4 fluoroquinolones, 2 macrolides, and rifampin. Trovafloxacin MICs were determined by a reference agar dilution method and E-test (Solna, Sweden) strips on buffered charcoal yeast extract agar. Among the fluoroquinolone compounds, the rank order of activity (on the basis of MIC90 results) determined with E-test strips was as follows: levofloxacin (MIC90, 0.094 microgram/ml) > trovafloxacin = sparfloxacin = ofloxacin (MIC90, 0.19 microgram/ml). Rifampin (MIC90, 0.008 microgram/ ml) and clarithromycin (MIC90, 0.032 microgram/ml) were the most potent of all drugs tested, and erythromycin and ciprofloxacin were the least active. In this study, the E-test strips with trovafloxacin were validated (100% of results +/- one log2 dilution compared to the reference value) for susceptibility testing with Legionella isolates.
Marco
F
F
Department of Pathology, University of Iowa College of Medicine, Iowa City 52242, USA.
Biedenbach
D J
DJ
Jones
R N
RN
D042462:4-Quinolones; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000494:pharmacology*; D024841:Fluoroquinolones; D016952:Legionella pneumophila / Q000187:drug effects*; D018942:Macrolides; D008826:Microbial Sensitivity Tests; D009287:Naphthyridines / Q000494:pharmacology*
D042462:4-Quinolones; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D018942:Macrolides; D009287:Naphthyridines; C080163:trovafloxacin