Interneuron migration from basal forebrain to neocortex: dependence on Dlx genes.
Although previous analyses indicate that neocortical neurons originate from the cortical proliferative zone, evidence suggests that a subpopulation of neocortical interneurons originates within the subcortical telencephalon. For example, gamma-aminobutyric acid (GABA)-expressing cells migrate in vitro from the subcortical telencephalon into the neocortex. The number of GABA-expressing cells in neocortical slices is reduced by separating the neocortex from the subcortical telencephalon. Finally, mice lacking the homeodomain proteins DLX-1 and DLX-2 show no detectable cell migration from the subcortical telencephalon to the neocortex and also have few GABA-expressing cells in the neocortex.
Anderson
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SA
Nina Ireland Laboratory of Developmental Neurobiology, Center for Neurobiology and Psychiatry, Department of Psychiatry, University of California at San Francisco, CA 94143-0984, USA.
Eisenstat
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DD
Shi
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Rubenstein
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JL
D000818:Animals; D064026:Calbindins; D002465:Cell Movement; D003342:Corpus Striatum / Q000166:cytology* / Q000196:embryology / Q000378:metabolism; D046508:Culture Techniques; D003598:Cytoskeletal Proteins; D004268:DNA-Binding Proteins / Q000235:genetics* / Q000502:physiology; D005801:Genes, Homeobox; D005968:Glutamate Decarboxylase / Q000378:metabolism; D018398:Homeodomain Proteins / Q000235:genetics* / Q000502:physiology; D007395:Interneurons / Q000737:chemistry / Q000502:physiology*; D051379:Mice; D009154:Mutation; D019579:Neocortex / Q000166:cytology* / Q000196:embryology / Q000378:metabolism; D016601:RNA-Binding Proteins; D064030:S100 Calcium Binding Protein G / Q000032:analysis; D013687:Telencephalon / Q000166:cytology* / Q000196:embryology / Q000378:metabolism; D014157:Transcription Factors; D005680:gamma-Aminobutyric Acid / Q000032:analysis
D064026:Calbindins; D003598:Cytoskeletal Proteins; D004268:DNA-Binding Proteins; C088334:Distal-less homeobox proteins; D018398:Homeodomain Proteins; D016601:RNA-Binding Proteins; D064030:S100 Calcium Binding Protein G; C093661:Tes protein, mouse; D014157:Transcription Factors; D005680:gamma-Aminobutyric Acid; D005968:Glutamate Decarboxylase