title: Epstein-Barr virus-associated lymphoproliferative eruption with progression to large granular lymphocytic leukaemia.
abstract: A 12-year-old Korean girl gave a 9-year history of recurrent necrotizing papules and vesicles on the face, scalp and extremities. Skin biopsy specimens showed an atypical lymphoreticular infiltrate with vasculitis in the dermis and subcutis. In situ hybridization demonstrated latent infection by Epstein-Barr virus (EBV) of the lymphoid cells in the dermis. The disease was diagnosed as an EBV-associated lymphoproliferative skin eruption presenting as recurrent necrotic papulovesicles. The patient subsequently developed large granular lymphocytic leukaemia of natural killer cell origin. Our observations suggest that a patient with an EBV-associated lymphoproliferative skin eruption presenting with recurrent necrotic papulovesicles might progress to develop leukaemia as well as lymphoma.
authors.affiliation: Department of Dermatology, Seoul National University College of Medicine, Korea.
authors.forename: K H
authors.initials: KH
authors.lastname: Cho
authors.forename: C W
authors.initials: CW
authors.lastname: Kim
authors.forename: O S
authors.initials: OS
authors.lastname: Kwon
authors.forename: S G
authors.initials: SG
authors.lastname: Yang
authors.forename: K C
authors.initials: KC
authors.lastname: Park
authors.forename: M H
authors.initials: MH
authors.lastname: Park
authors.forename: H I
authors.initials: HI
authors.lastname: Cho
authors.forename: J G
authors.initials: JG
authors.lastname: Kim
mesh_terms: D002648:Child; D017809:Fatal Outcome; D005260:Female; D006566:Herpesviridae Infections / Q000150:complications* / Q000473:pathology; D004854:Herpesvirus 4, Human; D006801:Humans; D016130:Immunophenotyping; D007945:Leukemia, Lymphoid / Q000276:immunology / Q000473:pathology / Q000821:virology*; D008232:Lymphoproliferative Disorders / Q000150:complications / Q000473:pathology; D017193:Skin Diseases, Viral / Q000150:complications* / Q000473:pathology; D014412:Tumor Virus Infections / Q000150:complications* / Q000473:pathology