Investigation of the association of the CRTM and CRTL1 genes with radiographically evident osteoarthritis in subjects from the Rotterdam study.
OBJECTIVE
To investigate whether radiographically evident osteoarthritis (ROA) in 55-65-year-old men and women is associated with specific alleles or genotypes of the cartilage matrix protein (CRTM) and cartilage link protein (CRTL1) genes.


METHODS
Cases were selected from a population-based study on the presence of ROA of the knee or hip. Further radiographic analysis included scoring for spine and hand ROA. Controls, selected from the same population, were free of ROA in all joints.


RESULTS
The CRTM locus was significantly associated with hip ROA in men (odds ratio 0.50, 95% confidence interval 0.26-0.95). A significant association between ROA and the CRTL1 gene was not observed.


CONCLUSIONS
These results suggest that the CRTM locus may play a role in the sex- and joint site-specific pattern of ROA development.
Meulenbelt
I
I
Gaubius Laboratory, and University Hospital, Leiden, The Netherlands.
Bijkerk
C
C
de Wildt
S C
SC
Miedema
H S
HS
Valkenburg
H A
HA
Breedveld
F C
FC
Pols
H A
HA
Te Koppele
J M
JM
Sloos
V F
VF
Hofman
A
A
Slagboom
P E
PE
van Duijn
C M
CM
D000368:Aged; D064236:Cartilage Oligomeric Matrix Protein; D016326:Extracellular Matrix Proteins; D005260:Female; D005796:Genes; D006023:Glycoproteins / Q000235:genetics*; D006621:Hip Joint; D006801:Humans; D008297:Male; D064235:Matrilin Proteins; D008875:Middle Aged; D010003:Osteoarthritis / Q000000981:diagnostic imaging* / Q000235:genetics*; D011506:Proteins / Q000235:genetics*; D011509:Proteoglycans; D011859:Radiography; D012727:Sex Characteristics; D000099249:Proteoglycan Link Protein
D064236:Cartilage Oligomeric Matrix Protein; D016326:Extracellular Matrix Proteins; D006023:Glycoproteins; D064235:Matrilin Proteins; D011506:Proteins; D011509:Proteoglycans; D000099249:Proteoglycan Link Protein; C577539:MATN1 protein, human; C577553:TSP5 protein, human