Behavioral effects of trichloroethylene and tetrachloroethylene in mice.
This study was performed to clarify the toxicological profiles of trichloroethylene (TRCE) and tetrachloroethylene (TECE) when they are administered intraperitoneally in mice. The ED50 for loss of righting reflex were 2596 mg/kg in TRCE and 4209 mg/kg in TECE. TRCE and TECE impaired bridge test performance at 500 and 2000 mg/kg, respectively. An operant behavior performance was also inhibited by TRCE at 1000 mg/kg and by TECE at 2000 mg/kg. Both TRCE and TECE exhibited anticonflict effects in a Vogel-type task at 500 mg/kg. This effect was confirmed by the finding that TRCE exhibited anticonflict action in a Geller-type paradigm at 250 mg/kg and more, as did TRCE did at 1000 mg/kg. These results show that TRCE and TECE affect various behaviors in mice and suggest that conflict behaviors are one of the most sensitive behavioral indicators of the effects of these substances. The toxicological profiles of TRCE and TECE with respect to behavioral effects were very similar, and they can be classified in a single category.
Umezu
T
T
Regional Enviroment Division, National Institute for Environmental Studies, Ibaraki, Japan.
Yonemoto
J
J
Soma
Y
Y
Miura
T
T
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D003216:Conditioning, Operant / Q000187:drug effects; D003220:Conflict, Psychological; D004305:Dose-Response Relationship, Drug; D007274:Injections, Intraperitoneal; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D004856:Postural Balance / Q000187:drug effects; D012018:Reflex / Q000187:drug effects; D012997:Solvents / Q000008:administration & dosage / Q000633:toxicity*; D013750:Tetrachloroethylene / Q000008:administration & dosage / Q000633:toxicity*; D014241:Trichloroethylene / Q000008:administration & dosage / Q000633:toxicity*
D012997:Solvents; D014241:Trichloroethylene; D013750:Tetrachloroethylene