title: Trigeminal neuralgia in patients with multiple sclerosis: lesion localization with magnetic resonance imaging.
abstract: We performed conventional T2-weighted brain MRI examinations in six patients with multiple sclerosis (MS) and trigeminal neuralgia. In all patients brainstem lesions in positions expected to involve trigeminal fibers, particularly the entry zone of sensory fibers, were demonstrated. Compression of the trigeminal nerve by ectatic vessels, a recognized cause of idiopathic trigeminal neuralgia, was not observed. We conclude that in MS trigeminal neuralgia is usually caused by demyelinating lesions affecting pontine trigeminal pathways.
authors.affiliation: Multiple Sclerosis NMR Research Unit, Institute of Neurology, London, UK.
authors.forename: A
authors.initials: A
authors.lastname: Gass
authors.forename: N
authors.initials: N
authors.lastname: Kitchen
authors.forename: D G
authors.initials: DG
authors.lastname: MacManus
authors.forename: I F
authors.initials: IF
authors.lastname: Moseley
authors.forename: M G
authors.initials: MG
authors.lastname: Hennerici
authors.forename: D H
authors.initials: DH
authors.lastname: Miller
mesh_terms: D000328:Adult; D000368:Aged; D001933:Brain Stem / Q000473:pathology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000150:complications* / Q000175:diagnosis*; D014276:Trigeminal Nerve / Q000473:pathology; D014277:Trigeminal Neuralgia / Q000150:complications* / Q000175:diagnosis*