title: Gene for nonspecific X-linked mental retardation (MRX 47) is located in Xq22.3-q24.
abstract: We describe a large family with nonspecific X-linked mental retardation (MRX 47). An X-linked recessive transmission is suggested by the inheritance from the mothers in two generations of a moderate to severe form of mental retardation in six males, without any specific clinical findings. Two point linkage analysis demonstrated significant linkage between the disorder and two markers in Xq23 (Zmax = 3.75, theta = 0). Multipoint linkage analyses confirmed the significant linkage with a maximum lod score (Z = 3.96, theta = 0) at DXS1059. Recombination events observed with the flanking markers DXS1105 and DXS8067 delineate a 17 cM interval. This interval overlaps with several loci of XLMR disorders previously localized in Xq23-q24, which are reviewed herein.
authors.affiliation: INSERM U129-ICGM, Faculté de Médecine Cochin, Paris, France.
authors.forename: V
authors.initials: V
authors.lastname: des Portes
authors.forename: N
authors.initials: N
authors.lastname: Soufir
authors.forename: A
authors.initials: A
authors.lastname: Carrié
authors.forename: P
authors.initials: P
authors.lastname: Billuart
authors.forename: T
authors.initials: T
authors.lastname: Bienvenu
authors.forename: M C
authors.initials: MC
authors.lastname: Vinet
authors.forename: C
authors.initials: C
authors.lastname: Beldjord
authors.forename: G
authors.initials: G
authors.lastname: Ponsot
authors.forename: A
authors.initials: A
authors.lastname: Kahn
authors.forename: J
authors.initials: J
authors.lastname: Boué
authors.forename: J
authors.initials: J
authors.lastname: Chelly
mesh_terms: D002874:Chromosome Mapping; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D008607:Intellectual Disability / Q000235:genetics*; D008126:Lod Score; D008297:Male; D010375:Pedigree; D011995:Recombination, Genetic; D014960:X Chromosome
chemical_list: D005819:Genetic Markers