Development of an antimicrobial susceptibility surveillance system for Neisseria gonorrhoeae in Malawi: comparison of methods.
Susceptibility of Neisseria gonorrhoeae to gentamicin, the primary treatment for gonorrhea in Malawi since 1993, was determined by using agar dilution MICs, E-test MICs, disc diffusion, and clinical cure rate. Agar dilution MICs were slightly higher in 1996 than in 1993 isolates, with a concomitant drop in the clinical cure rate. E-test MICs were substantially lower than agar dilution determinations, with only 77.4% within 1 log2 concentration.
Daly
C C
CC
John Snow, Inc., Boston, Massachusetts, USA.
Hoffman
I
I
Hobbs
M
M
Maida
M
M
Zimba
D
D
Davis
R
R
Mughogho
G
G
Cohen
M S
MS
D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000627:therapeutic use; D005839:Gentamicins / Q000494:pharmacology* / Q000627:therapeutic use; D006069:Gonorrhea / Q000188:drug therapy* / Q000382:microbiology; D006801:Humans; D008295:Malawi; D008826:Microbial Sensitivity Tests / Q000379:methods*; D009344:Neisseria gonorrhoeae / Q000187:drug effects* / Q000302:isolation & purification; D014521:Urethra / Q000382:microbiology
D000900:Anti-Bacterial Agents; D005839:Gentamicins