Audiogenic seizures after neck tourniquet-induced cerebral ischemia in the rat.
Development of audiogenic seizures (AGS) and their correlation with neurodegeneration were studied after 7.5 min of whole-brain ischemia. One day post-ischemia, all animals became hyperreactive and responded to auditory stimulation by generalized seizures. Neuronal necrosis developed already 6 h post-ischemia in inferior colliculi, reticular thalamic nucleus and hippocampal hilar region. Repeated ischemia did not induce any neurological changes, suggesting that the neurological effects are consequences of selective neuronal injury.
Vanický
I
I
Institute of Neurobiology, Slovak Academy of Sciences, Kosice, Slovak Republic.
Cízková
D
D
Prosbová
T
T
Marsala
M
M
D000161:Acoustic Stimulation; D000818:Animals; D002545:Brain Ischemia / Q000150:complications / Q000503:physiopathology*; D004195:Disease Models, Animal; D007245:Inferior Colliculi / Q000098:blood supply* / Q000503:physiopathology; D009333:Neck; D051381:Rats; D017208:Rats, Wistar; D012640:Seizures / Q000209:etiology / Q000503:physiopathology*; D016622:Silver Staining; D014111:Tourniquets