Antiemetic inhibits conditioned taste aversion, but not the hypophagia induced by epinephrine.
It has been shown that relatively high doses of epinephrine (E) injected intraperitoneally (IP) produce hypophagia and conditioned taste aversion (CTA) in rats. We examined the possibility that E effects involve malaise. For this purpose, changes in saccharin preference induced by E injected IP (100 microg/kg) were determined after a previous administration of trimethobenzamide (TMB, 5 mg/kg), an antiemetic agent. E alone decreased saccharin preference by 54% (p < 0.01), but only by 16% (not significant) in the presence of TMB. In contrast, the injection of 75 or 100 microg/kg E reduced food intake by 50 and 85%, respectively (p < 0.01), regardless of previous injection of TMB. In conclusion, the results suggest that E-induced malaise is not the direct cause of the hypophagia it elicits.
Racotta
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IS
División de Biología Marina, Centro de Investigaciones Biológicas del Noroeste, La Paz, BCS, México.
Arzuffi
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Garduño
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Racotta
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R
D000818:Animals; D000932:Antiemetics / Q000494:pharmacology*; D001245:Association Learning / Q000187:drug effects*; D001362:Avoidance Learning / Q000187:drug effects*; D001549:Benzamides / Q000494:pharmacology*; D003214:Conditioning, Classical / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004435:Eating / Q000187:drug effects*; D004837:Epinephrine / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D008297:Male; D009042:Motivation; D051381:Rats; D017208:Rats, Wistar; D013649:Taste / Q000187:drug effects*
D000932:Antiemetics; D001549:Benzamides; C100146:trimethobenzamide; D004837:Epinephrine