title: Transitional cell carcinoma in situ of the seminal vesicles: 8 cases with discussion of pathogenesis, and clinical and biological implications.
abstract: OBJECTIVE
  Mucosal migration of transitional cell carcinoma in situ is a potential mechanism for multifocal lower tract disease.
  
  
  METHODS
  The clinical course and pathological studies of 8 cases of carcinoma in situ are reviewed in detail.
  
  
  RESULTS
  The pattern of disease of carcinoma in situ of seminal vesicle provides circumstantial evidence for mucosal migration of cancer from a bladder or prostatic urethral origin.
  
  
  CONCLUSIONS
  A monoclonal origin of bladder cancer combined with mucosal spread of carcinoma in situ suggests that incomplete destruction of carcinoma in situ may adversely affect long-term results by permitting extension into the distal ureters, prostatic duct or seminal vesicles. Protracted intravesical treatment of carcinoma in situ without complete elimination of the disease allows the natural history of mucosal spread to become evident.
authors.affiliation: Department of Surgery, University of Michigan, Ann Arbor 48109-0330, USA.
authors.forename: J E
authors.initials: JE
authors.lastname: Montie
authors.forename: K
authors.initials: K
authors.lastname: Wojno
authors.forename: E
authors.initials: E
authors.lastname: Klein
authors.forename: C
authors.initials: C
authors.lastname: Pearsall
authors.forename: H
authors.initials: H
authors.lastname: Levin
mesh_terms: D000368:Aged; D002278:Carcinoma in Situ / Q000209:etiology* / Q000473:pathology*; D002295:Carcinoma, Transitional Cell / Q000209:etiology* / Q000473:pathology*; D005834:Genital Neoplasms, Male / Q000209:etiology* / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009378:Neoplasms, Multiple Primary / Q000209:etiology* / Q000473:pathology*; D012669:Seminal Vesicles