Calcipotriol/calcipotriene (Dovonex/Daivonex) in combination with phototherapy: a review.
BACKGROUND
Calcipotriol/calcipotriene (Dovonex/Daivonex) ointment plus phototherapy has been used in the treatment of psoriasis.


OBJECTIVE
We will attempt to clarify two issues: First, is there any benefit to combining the above treatment modalities? Second, is there any increased risk associated with the use of the combination?


METHODS
A complete review of the literature revealed four studies dealing with the combination of calcipotriol with UVB phototherapy and three studies dealing with the combination of calcipotriol with PUVA phototherapy.


RESULTS
These studies showed an advantage to the use of the combination compared with the use of either treatment alone.


CONCLUSIONS
Topical calcipotriol enhances the effect of UVB and PUVA phototherapy.
Koo
J
J
UCSF Psoriasis and Skin Treatment Center, University of California, San Francisco 94143, USA.
D002117:Calcitriol / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D003131:Combined Modality Therapy; D018849:Controlled Clinical Trials as Topic; D003879:Dermatologic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D015337:Multicenter Studies as Topic; D011701:PUVA Therapy; D010789:Phototherapy; D011565:Psoriasis / Q000188:drug therapy / Q000628:therapy*; D012306:Risk; D014467:Ultraviolet Therapy
D003879:Dermatologic Agents; C055085:calcipotriene; D002117:Calcitriol