title: Malignant proliferating trichilemmal tumor showing distant metastases.
abstract: We describe a case of malignant proliferating trichilemmal tumor showing multiple distant metastases. For 10 years, the patient had had a round mass in the occiput, which recurred twice after wide excisions, and later metastasized to the cervical lymph nodes, periparotid area, and chest. Each time the lesions were excised, histologic specimens demonstrated a proliferating trichilemmal tumor with increasing nuclear atypia. Serial specimens showed increasing Ki-67 positivity as the extent of the tumor advanced.
authors.affiliation: Department of Dermatology, Seoul National University College of Medicine, Korea.
authors.forename: B S
authors.initials: BS
authors.lastname: Park
authors.forename: S G
authors.initials: SG
authors.lastname: Yang
authors.forename: K H
authors.initials: KH
authors.lastname: Cho
mesh_terms: D000328:Adult; D002455:Cell Division; D002467:Cell Nucleus / Q000648:ultrastructure; D006258:Head and Neck Neoplasms / Q000556:secondary; D006801:Humans; D019394:Ki-67 Antigen / Q000032:analysis; D008207:Lymphatic Metastasis / Q000473:pathology*; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D018295:Neoplasms, Basal Cell / Q000473:pathology* / Q000556:secondary; D012535:Scalp / Q000473:pathology*; D012878:Skin Neoplasms / Q000473:pathology*; D013899:Thoracic Neoplasms / Q000556:secondary
chemical_list: D019394:Ki-67 Antigen