title: The functional matrix hypothesis revisited. 4. The epigenetic antithesis and the resolving synthesis.
abstract: In two interrelated articles, the current revision of the functional matrix hypothesis extends to a reconsideration of the relative roles of genomic and of epigenetic processes and mechanisms in the regulation (control, causation) of craniofacial growth and development. The dialectical method was chosen to analyze this matter, because it explicitly provides for the fuller presentation of a genomic thesis, an epigenetic antithesis, and a resolving synthesis. The later two are presented here, where the synthesis suggests that both genomic and epigenetic factors are necessary causes, that neither alone is also a sufficient cause, and that only the two, interacting together, furnish both the necessary and sufficient cause(s) of ontogenesis. This article also provides a comprehensive bibliography that introduces the several new, and still evolving, disciplines that may provide alternative viewpoints capable of resolving this continuing controversy; repetition of the present theoretical bases for the arguments on both sides of these questions seems nonproductive. In their place, it is suggested that the group of disciplines, broadly termed Complexity, would most likely amply repay deeper consideration and application in the study of ontogenesis.
authors.affiliation: Department of Anatomy and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA. moss@civil.columbia.edu
authors.forename: M L
authors.initials: ML
authors.lastname: Moss
mesh_terms: D001696:Biomechanical Phenomena; D001846:Bone Development / Q000235:genetics / Q000502:physiology; D002454:Cell Differentiation / Q000235:genetics / Q000502:physiology; D004247:DNA / Q000235:genetics; D004777:Environment; D016678:Genome; D006128:Growth; D006801:Humans; D008445:Maxillofacial Development / Q000235:genetics* / Q000502:physiology; D008954:Models, Biological; D009024:Morphogenesis / Q000235:genetics / Q000502:physiology
chemical_list: D004247:DNA