In vitro study of the mechanical effects of shock-wave lithotripsy.
Impulsive stress in repeated shock waves administered during extracorporeal shock-wave lithotripsy (ESWL) causes injury to kidney tissue. In a study of the mechanical input of ESWL, the effects of focused shock waves on thin planar polymeric membranes immersed in a variety of tissue-mimicking fluids have been examined. A direct mechanism of failure by shock compression and an indirect mechanism by bubble collapse have been observed. Thin membranes are easily damaged by bubble collapse. After propagating through cavitation-free acoustically heterogeneous media (liquids mixed with hollow glass spheres, and tissue) shock waves cause membranes to fail in fatigue by a shearing mechanism. As is characteristic of dynamic fatigue, the failure stress increases with strain rate, determined by the amplitude and rise time of the attenuated shock wave. Shocks with large amplitude and short rise time (i.e., in uniform media) cause no damage. Thus the inhomogeneity of tissue is likely to contribute to injury in ESWL. A definition of dose is proposed which yields a criterion for damage based on measurable shock wave properties.
Howard
D
D
Graduate Aeronautical Laboratories, California Institute of Technology, Pasadena 91125, USA.
Sturtevant
B
B
D002368:Castor Oil; D003101:Collodion; D003238:Connective Tissue / Q000293:injuries*; D019855:Ethylene Glycol; D005898:Glass; D005990:Glycerol; D019220:High-Energy Shock Waves; D066298:In Vitro Techniques; D008096:Lithotripsy / Q000009:adverse effects*; D008433:Mathematics; D008567:Membranes, Artificial; D008863:Microspheres; D008954:Models, Biological; D019047:Phantoms, Imaging; D013314:Stress, Mechanical; D014867:Water
D008567:Membranes, Artificial; D014867:Water; D002368:Castor Oil; D003101:Collodion; D019855:Ethylene Glycol; D005990:Glycerol