title: Analysis of harvest morbidity and radiographic outcome using autograft for anterior cervical fusion.
abstract: METHODS
  Retrospective study of 184 autologous iliac crest bone grafts used for anterior cervical fusion in 144 procedures.
  
  
  OBJECTIVE
  To evaluate the effect of autologous iliac crest bone graft harvest site on operation and recovery and to identify patients at risk for harvest morbidity.
  
  
  BACKGROUND
  Although autologous iliac crest bone graft is considered the most successful grafting material, concerns about harvest morbidity provide a rationale for considering allograft. Data about the use of autograft therefore would assist spinal surgeons in selecting the appropriate substrates for fusion after anterior cervical decompression.
  
  
  METHODS
  Statistical analysis based on patient gender, smoking history, obesity, and medical or pharmacologic risk factors for wound healing was used to evaluate morbidity after patient interviews and examinations. Limited assessment of radiographic outcome also was performed.
  
  
  RESULTS
  A second operation because of donor site morbidity was performed in four patients (2.8%), but only one (0.7%) with meralgia paresthetica had permanent sequelae. Superficial wound infection or dehiscence occurred in 5.6% of patients, with a disproportionate number of women, obese patients, and those with medical risk represented. Protracted wound symptoms of pain and poor cosmesis were reported in 2.8% and 3.5% of patients, respectively, and also were found in a significant number of female and obese patients. Evidence of fusion was present in 97% of cases.
  
  
  CONCLUSIONS
  Autologous iliac crest bone graft harvest results in minimal major morbidity when regional anatomy is respected and careful technique is observed. The identification of patients at risk for minor complications suggests that allograft may be appropriate in these patients; however, prospective comparison is required to identify whether graft material or technical factors determine fusion success and relative benefit.
authors.affiliation: Division of Neurosurgery, University of Pennsylvania, Philadelphia 19104, USA.
authors.forename: C L
authors.initials: CL
authors.lastname: Schnee
authors.forename: A
authors.initials: A
authors.lastname: Freese
authors.forename: R J
authors.initials: RJ
authors.lastname: Weil
authors.forename: P J
authors.initials: PJ
authors.lastname: Marcotte
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016025:Bone Transplantation; D002574:Cervical Vertebrae / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D007085:Ilium / Q000637:transplantation*; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D009017:Morbidity; D011859:Radiography; D012086:Reoperation; D012189:Retrospective Studies; D013123:Spinal Fusion / Q000009:adverse effects / Q000379:methods*; D014182:Transplantation, Autologous; D016896:Treatment Outcome; D014946:Wound Infection / Q000209:etiology / Q000473:pathology