Effect of combined neonatal imprinting by vitamin A, vitamin D3, benzpyrene and allylestrenol on adult rat thymus glucocorticoid and uterine estrogen receptors.
1. Combined neonatal imprinting with allylestrenol, vitamins A and D3 and benzpyrene significantly increased thymic glucocorticoid receptor capacity in male and female animals and decreased receptors affinity in adult females only. 2. Uterine estrogen receptor affinity or density was not influenced. 3. Considering that perinatal treatment with allylestrenol or vitamin D3 decreased glucocorticoid receptor capacity, the dominance of the positive effect of retinol should be surmised. 4. The experiments call attention to the interrelation of different materials acting simultaneously in the perinatal period.
Csaba
G
G
Department of Biology, Semmelweis University of Medicine, Budapest, Hungary.
Inczefi-Gonda
A
A
D000500:Allylestrenol / Q000494:pharmacology*; D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D000893:Anti-Inflammatory Agents / Q000378:metabolism; D001564:Benzo(a)pyrene / Q000494:pharmacology*; D002762:Cholecalciferol / Q000494:pharmacology*; D003600:Cytosol / Q000187:drug effects / Q000378:metabolism; D003907:Dexamethasone / Q000378:metabolism; D005260:Female; D066298:In Vitro Techniques; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D011960:Receptors, Estrogen / Q000187:drug effects*; D011965:Receptors, Glucocorticoid / Q000187:drug effects*; D013950:Thymus Gland / Q000187:drug effects / Q000378:metabolism*; D014599:Uterus / Q000187:drug effects / Q000378:metabolism*; D014801:Vitamin A / Q000494:pharmacology*
D000893:Anti-Inflammatory Agents; D011960:Receptors, Estrogen; D011965:Receptors, Glucocorticoid; D014801:Vitamin A; D002762:Cholecalciferol; D001564:Benzo(a)pyrene; D003907:Dexamethasone; D000500:Allylestrenol