In vivo lipid peroxidation responses of tissues in lead-treated Swiss mice.
A single intraperitoneal injection of lead acetate (200 mg/kg body weight) increased the lipid peroxidation potential (LPP) measured as thiobarbituric acid-reactive substance (TBA-RS) in different tissues of Swiss mice. All the tissues taken for experimentation, generated significantly higher amount of TBA-RS in lead-treated mice when compared with the respective control value. However, none of the tissues could correspond to the control value after the lapse of four weeks post-treatment. Possibilities of differential responsiveness of tissues to generate lipid peroxides in lead-treated mice have been discussed.
Acharya
S
S
Department of Zoology, Berhampur University, India.
Acharya
U R
UR
D000818:Animals; D001921:Brain / Q000187:drug effects; D007668:Kidney / Q000187:drug effects; D007854:Lead / Q000633:toxicity*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D051379:Mice; D009942:Organometallic Compounds / Q000633:toxicity*; D013737:Testis / Q000187:drug effects
D009942:Organometallic Compounds; D007854:Lead; C008261:lead acetate