title: Hemophilic synovitis of the knee and the elbow.
abstract: A prospective study from 1974 to 1996 was done to determine optimal treatment for chronic hemophilic synovitis of the knee and synovitis of the elbow. Sixty-five patients with synovitis affecting 65 knee joints and 40 patients who had synovitis of the elbow (44 elbows), despite a 3-month trial of prophylactic substitution therapy, were treated by synovectomy. Radiation synovectomies (Au-198 synoviorthesis) were done on 38 knees, open surgical synovectomy on 18, and nine had an arthroscopic procedure. Radioactive gold synoviorthesis was performed on 29 elbows, and 15 had a resection of the radial head and partial open synovectomy. Synovectomy (by any method) significantly reduced bleeding episodes, but did not halt the radiographic deterioration of the joints. It is thought that radiation synovectomy is the best choice for patients with persistent synovitis of the knee and synovitis of the elbow unresponsive to a 3-month trial of prophylactic factor replacement. If two to three consecutive synoviortheses with 3 to 6 months intervals had been ineffective, or when the radiographic score is more than two points, an open synovectomy is indicated.
authors.affiliation: International Hemophilia Treatment and Training Center, La Paz University Hospital, Madrid, Spain.
authors.forename: E C
authors.initials: EC
authors.lastname: Rodríguez-Merchán
authors.forename: M
authors.initials: M
authors.lastname: Magallón
authors.forename: E
authors.initials: E
authors.lastname: Galindo
authors.forename: C
authors.initials: C
authors.lastname: López-Cabarcos
mesh_terms: D000293:Adolescent; D000328:Adult; D001182:Arthroscopy; D002648:Child; D002908:Chronic Disease; D018450:Disease Progression; D004551:Elbow Joint / Q000473:pathology*; D004724:Endoscopy; D005169:Factor VIII / Q000008:administration & dosage / Q000627:therapeutic use; D005500:Follow-Up Studies; D006050:Gold Radioisotopes / Q000008:administration & dosage / Q000627:therapeutic use; D006395:Hemarthrosis / Q000209:etiology / Q000517:prevention & control; D006467:Hemophilia A / Q000150:complications* / Q000517:prevention & control; D006801:Humans; D007270:Injections, Intra-Articular; D007592:Joint Diseases / Q000000981:diagnostic imaging / Q000209:etiology; D007719:Knee Joint / Q000473:pathology*; D011446:Prospective Studies; D011859:Radiography; D019275:Radiopharmaceuticals / Q000008:administration & dosage / Q000627:therapeutic use; D011884:Radius / Q000601:surgery; D012008:Recurrence; D000074402:Synovectomy; D013585:Synovitis / Q000209:etiology* / Q000517:prevention & control / Q000532:radiotherapy / Q000601:surgery; D016896:Treatment Outcome; D015021:Yttrium Radioisotopes / Q000008:administration & dosage / Q000627:therapeutic use
chemical_list: D006050:Gold Radioisotopes; D019275:Radiopharmaceuticals; D015021:Yttrium Radioisotopes; D005169:Factor VIII