title: Rhabdomyolysis, acute renal failure and hepatopathy induced by lovastatin monotherapy.
abstract: Lovastatin is a popular drug for the treatment of hypercholesterolemia. Few serious complications are associated with its use although rhabdomyolysis with renal failure has been reported when lovastatin is combined with cyclosporine or other drugs following transplantation. We report the case of a patient who developed hepatopathy and rhabdomyolysis accompanied by acute renal failure after 4 weeks of lovastatin monotherapy. The pathogenesis and treatment of these complications are also discussed.
authors.affiliation: Department of Internal Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan.
authors.forename: P H
authors.initials: PH
authors.lastname: Chu
authors.forename: W J
authors.initials: WJ
authors.lastname: Chen
authors.forename: C W
authors.initials: CW
authors.lastname: Chiang
authors.forename: Y S
authors.initials: YS
authors.lastname: Lee
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced*; D000924:Anticholesteremic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000188:drug therapy; D008148:Lovastatin / Q000008:administration & dosage / Q000009:adverse effects*; D008875:Middle Aged; D012206:Rhabdomyolysis / Q000139:chemically induced*
chemical_list: D000924:Anticholesteremic Agents; D008148:Lovastatin