Anti-platelet aggregation activity of some pyrazines.
This report describes the anti-platelet aggregation activity of 48 pyrazines. Among alkyl- and arylpyrazines tested, 2,3-diphenylpyrazines showed the strongest anti-platelet aggregation activity. Then, various substituents were introduced into the phenyl groups, and the 2,3-bis(p-methoxyphenyl)pyrazine derivatives were consequently found to possess considerably strong inhibitory activity.
Ohta
A
A
Tokyo University of Pharmacy and Life Science, Japan.
Takahashi
H
H
Miyata
N
N
Hirono
H
H
Nishio
T
T
Uchino
E
E
Yamada
K
K
Aoyagi
Y
Y
Suwabe
Y
Y
Fujitake
M
M
Suzuki
T
T
Okamoto
K
K
D000818:Animals; D016718:Arachidonic Acid / Q000633:toxicity; D003094:Collagen / Q000633:toxicity; D004353:Drug Evaluation, Preclinical; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D011719:Pyrazines / Q000737:chemistry / Q000494:pharmacology*; D011817:Rabbits; D013329:Structure-Activity Relationship
D010975:Platelet Aggregation Inhibitors; D011719:Pyrazines; D016718:Arachidonic Acid; D003094:Collagen