The embryonic and post-natal expression of the nicotinic receptor alpha 3-subunit in rat lower brainstem.
The mRNA expression of the alpha 3 nicotinic acetylcholine receptor subunit in the rat lower brainstem is more widespread in the embryo and at birth than in the mature brain, but the major cell groups expressing alpha 3 are generally the same, with two exceptions. The transcript for the alpha 3-subunit is transiently expressed in the ventral cochlear nucleus (VCN). Expression was very high in the embryonic and early post-natal VCN, but was significantly decreased in the VCN late in the post-natal period (about post-natal day 15). Conversely, alpha 3 mRNA was not expressed in the motor trigeminal nucleus until about PN3.
Morley
B J
BJ
Neurochemistry Laboratory, Boys Town National Research Hospital, Omaha, NE 68131, USA. morley@boystown.org
D000818:Animals; D001933:Brain Stem / Q000196:embryology / Q000254:growth & development / Q000378:metabolism*; D004622:Embryo, Mammalian / Q000378:metabolism; D005314:Embryonic and Fetal Development / Q000502:physiology; D005260:Female; D008297:Male; D010446:Peptide Fragments / Q000096:biosynthesis*; D051381:Rats; D017207:Rats, Sprague-Dawley; D011978:Receptors, Nicotinic / Q000096:biosynthesis*
D010446:Peptide Fragments; D011978:Receptors, Nicotinic