title: Failed Nissen fundoplication in two patients who had persistent vomiting and eosinophilic esophagitis.
abstract: The following report describes two patients who had chronic symptoms of gastroesophageal reflux and persistent histological esophagitis, despite aggressive medical antireflux therapy, who continued to have esophagitis and remained symptomatic post antireflux surgery (Nissen fundoplication). Both patients demonstrated a severe eosinophilic esophagitis with normal gastric and duodenal histology before and after surgery. Postoperatively, each received the diagnosis of allergic enteritis and both responded clinically and histologically to oral corticosteroids and an elemental diet.
authors.affiliation: Children's Hospital of Philadelphia, The University of Pennsylvania School of Medicine, USA.
authors.forename: C A
authors.initials: CA
authors.lastname: Liacouras
mesh_terms: D000293:Adolescent; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D002648:Child; D004802:Eosinophilia / Q000150:complications*; D004941:Esophagitis / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D005260:Female; D018662:Fundoplication / Q000379:methods*; D005764:Gastroesophageal Reflux / Q000150:complications* / Q000601:surgery*; D006801:Humans; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D012720:Severity of Illness Index; D017211:Treatment Failure; D014839:Vomiting / Q000150:complications*
chemical_list: D000893:Anti-Inflammatory Agents; D008775:Methylprednisolone