A bout of resistance exercise increases urinary calcium independently of osteoclastic activation in men.
Metabolic acidosis increases urinary calcium excretion in humans as a result of administration of ammonium chloride, an increase in dietary protein intake, and fasting-induced ketoacidosis. An intense bout of exercise, exceeding aerobic capacity, also causes significant decrease in blood pH as a result of increase in blood lactate concentration. In this study we investigated changes in renal calcium handling, plasma parathyroid hormone concentration, and osteoclastic bone resorption after a single bout of resistance exercise. Ten male subjects completed a bout of resistance exercise with an intensity of 60% of one repetition maximum for the first set and 80% of one repetition maximum for the second and third sets. After exercise, blood and urine pH shifted toward acidity and urinary calcium excretion increased. Hypercalciuria was observed in the presence of an increased fractional calcium excretion and an unchanged filtered load of calcium. Therefore, the observed increase in urinary calcium excretion was due primarily to decrease in renal tubular reabsorption of calcium. Likely causes of the increase in renal excretion of calcium are metabolic acidosis itself and decreased parathyroid hormone. When urinary calcium excretion increased, urinary deoxypyridinoline, a marker of osteoclastic bone resorption, decreased. These results suggest that 1) strenuous resistance exercise increased urinary calcium excretion by decreasing renal tubular calcium reabsorption, 2) urinary calcium excretion increased independently of osteoclast activation, and 3) the mechanism resulting in postexercise hypercalciuria might involve non-cell-mediated physicochemical bone dissolution.
Ashizawa
N
N
Laboratory of Biochemistry of Exercise and Nutrition, Institute of Health and Sport Sciences, University of Tsukuba, Tsukuba 305, Japan.
Fujimura
R
R
Tokuyama
K
K
Suzuki
M
M
D000138:Acidosis / Q000378:metabolism; D000328:Adult; D000693:Anaerobiosis / Q000502:physiology; D002118:Calcium / Q000737:chemistry / Q000378:metabolism / Q000652:urine*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003404:Creatinine / Q000652:urine; D006801:Humans; D008297:Male; D010010:Osteoclasts / Q000378:metabolism / Q000502:physiology*; D010281:Parathyroid Hormone / Q000097:blood; D013997:Time Factors; D014891:Weight Lifting / Q000502:physiology*
D010281:Parathyroid Hormone; D003404:Creatinine; D002118:Calcium