title: Bioconcentration and excretion of fenitrothion in the brain of the eel (Anguilla anguilla).
abstract: The bioconcentration of fenitrothion in the brain of the european eel (Anguilla anguilla) and its posterior elimination have been studied. Animals were exposed to a sublethal concentration of fenitrothion (0.04 mg/L) for 96 hours in a flow-through test system. After this pesticide exposure, animals were transferred to clean water for 72 hours more. Bioconcentration and elimination processes of fenitrothion were studied in blood and brain. This insecticide showed a strong tendency to bioconcentrate into selected tissues. A steady-state was observed in blood in few hours. Highest accumulation was detected in brain, where any steady-state could be observed. Elimination started rapidly from both tissues when a recovery period was allowed. Elimination kinetics were adjusted to one-compartment model. K2 of 0.015 and 0.044 hr-1 were calculated for fenitrothion in blood and brain. These K2 values were related with a relatively short half-live of fenitrothion in the analyzed tissues; probably due to the low biotransformation rate of this toxicant in the european eel. That fact would protect the animals against many biotransformation products even more toxic than the parent fenitrothion.
authors.affiliation: Department of Animal Biology (Animal Physiology), Faculty of Biology, University of Valencia, Spain.
authors.forename: E
authors.initials: E
authors.lastname: Sancho
authors.forename: M D
authors.initials: MD
authors.lastname: Ferrando
authors.forename: A
authors.initials: A
authors.lastname: Ten
authors.forename: E
authors.initials: E
authors.lastname: Andreu-Moliner
mesh_terms: D000704:Analysis of Variance; D000811:Anguilla; D000818:Animals; D001711:Biotransformation; D001921:Brain / Q000378:metabolism*; D005278:Fenitrothion / Q000032:analysis / Q000097:blood / Q000493:pharmacokinetics*; D007306:Insecticides / Q000097:blood / Q000493:pharmacokinetics*; D007928:Lethal Dose 50; D013030:Spain; D014874:Water Pollutants, Chemical / Q000032:analysis
chemical_list: D007306:Insecticides; D014874:Water Pollutants, Chemical; D005278:Fenitrothion