[Levels of serum KL-6 in a patient with drug-induced pneumonitis].
We describe a 67-year-old man in who serum KL-6 levels were measured during drug-induced pneumonia. The patient was hospitalized, because of coughing, fever, and dyspnea on exertion after administration of Sho-saiko-to (herbal medicine). After he was hospitalized, his symptoms were relieved, and the infiltration shadow on chest X-ray films resolved, but after re-administration of Sho-saiko-to, fever and hypoxemia developed. The serum KL-6 level was again high one day after oral re-administration of the drug. However, the level of lactate dehydrogenase in serum was not high after the re-administration. After treatment with on oral steroid drug the serum KL-6 level decreased gradually, symptoms were relieved the previously high level of c-reactive protein in serum decreased, the previously high white blood cell count decreased, and radiographic findings returned to normal. The diagnosis of drug-induced pneumonia is difficult, because specific diagnostic measures have not been developed. In the present case the serum KL-6 level increased rapidly after re-administration of the drug, and therefore measurement of serum KL-6 level may be helpful in the diagnosis of drug-induced pneumonia.
Nakajima
M
M
Department of Medicine, Kawasaki Medical School, Kurashiki, Japan.
Manabe
T
T
Mitekura
H
H
Hashiguchi
K
K
Niki
Y
Y
Matsushima
T
T
D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D000941:Antigens / Q000097:blood*; D000951:Antigens, Neoplasm; D015415:Biomarkers / Q000097:blood*; D004365:Drugs, Chinese Herbal / Q000009:adverse effects*; D006023:Glycoproteins / Q000097:blood*; D006801:Humans; D008297:Male; D018396:Mucin-1; D009077:Mucins / Q000097:blood*; D011014:Pneumonia / Q000097:blood* / Q000139:chemically induced*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000941:Antigens; D000951:Antigens, Neoplasm; D015415:Biomarkers; D004365:Drugs, Chinese Herbal; D006023:Glycoproteins; C060192:MUC1 protein, human; D018396:Mucin-1; D009077:Mucins; C018142:saiko-keishi-to