The value of immunoglobulin and complement levels in the early diagnosis of neonatal sepsis.
Serum IgG, IgG1, G2, G3, G4, IgM, C3c and C4 concentrations were measured in 24 term neonates with sepsis and 17 healthy normal neonates of similar age, sex and weight (control group). The serum IgG, IgG1, G2, G3, G4, IgM, C3c, and C4 levels were similar in the patients with sepsis and the control group (p > 0.05). In the neonates with sepsis, serum IgG, G1, G2, IgM and C4 levels were not significantly different between the 1st and 10th days, while there were significant differences for IgG3, G4 and C3c (p < 0.05). We conclude that the serum levels of IgG, IgG1, G2, G3, G4, IgM, C3c and C4 concentrations are of no value for the early diagnosis of neonatal sepsis.
Kalayci
A G
AG
Department of Paediatrics, Ondokuz Mayis University, School of Medicine, Samsun, Turkey.
Adam
B
B
Yilmazer
F
F
Uysal
S
S
Gürses
N
N
D016470:Bacteremia / Q000175:diagnosis* / Q000276:immunology; D001724:Birth Weight; D015932:Complement C3c / Q000378:metabolism*; D003181:Complement C4 / Q000378:metabolism*; D005260:Female; D005865:Gestational Age; D006801:Humans; D007136:Immunoglobulins / Q000097:blood*; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000175:diagnosis* / Q000276:immunology; D008297:Male; D011379:Prognosis; D012016:Reference Values
D003181:Complement C4; D007136:Immunoglobulins; D015932:Complement C3c