title: A randomized, double-blind, placebo controlled comparison of droperidol, ondansetron, and metoclopramide for the prevention of vomiting following outpatient strabismus surgery in children.
abstract: OBJECTIVE
  To compare the efficacy of ondansetron, droperidol, or metoclopramide with placebo in preventing postoperative vomiting following strabismus surgery.
  
  
  METHODS
  Randomized, double-blind, placebo-controlled clinical trial.
  
  
  METHODS
  University outpatient surgery center.
  
  
  METHODS
  160 ASA physical status I and II children ages 1 to 12 years who were scheduled for strabismus surgery.
  
  
  METHODS
  Administration of either ondansetron 100 mcg/kg, metoclopramide 250 mcg/kg, droperidol 75 mcg/kg, or placebo intravenously after induction of anesthesia.
  
  
  RESULTS
  Both ondansetron and droperidol were superior to metoclopramide and placebo in preventing predischarge vomiting, with incidences of 5%, 5%, 32%, and 25%, respectively. However, there was no difference in the incidence of postdischarge vomiting among the groups (ondansetron 25%, droperidol 25%, metoclopramide 20%, and placebo 25%).
  
  
  CONCLUSIONS
  While both ondansetron and droperidol are more effective than metoclopramide when compared with placebo in decreasing the incidence of predischarge vomiting, none of these drugs was more effective than placebo in decreasing the incidence of postdischarge vomiting. Recovery from anesthesia was not significantly different among the groups as assessed by time to awakening, initial Steward score, and time to discharge.
authors.affiliation: Department of Anesthesia, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, NC 27157-1009, USA.
authors.forename: P E
authors.initials: PE
authors.lastname: Scuderi
authors.forename: R G
authors.initials: RG
authors.lastname: Weaver
authors.forename: R L
authors.initials: RL
authors.lastname: James
authors.forename: G
authors.initials: G
authors.lastname: Mims
authors.forename: W G
authors.initials: WG
authors.lastname: Elliott
authors.forename: D B
authors.initials: DB
authors.lastname: Weeks
mesh_terms: D000556:Ambulatory Surgical Procedures; D000932:Antiemetics / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D004311:Double-Blind Method; D004329:Droperidol / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008787:Metoclopramide / Q000627:therapeutic use*; D017294:Ondansetron / Q000627:therapeutic use*; D011183:Postoperative Complications / Q000517:prevention & control; D011446:Prospective Studies; D013285:Strabismus / Q000601:surgery*; D014839:Vomiting / Q000517:prevention & control*
chemical_list: D000932:Antiemetics; D017294:Ondansetron; D008787:Metoclopramide; D004329:Droperidol