The value of immunohistochemical identification of neuroendocrine differentiation in non small cell lung carcinoma.
Neuroendocrine differentiation (NE) has been found to be a feature of neuroendocrine tumours and also a proportion of non-small cell lung carcinomas. Detection of NE by immunohistochemical assays depends on spectrum of used antibodies and criteria. Immunohistochemical identification of NE in non-small cell lung cancer has been discussed in an article together with criteria, diagnostic helpfulness and prognostic value of this feature.
Słodkowska
J
J
Department of Pathology, National Institute of Tuberculosis and Lung Diseases, Warsaw, Poland.
D014408:Biomarkers, Tumor / Q000032:analysis*; D018278:Carcinoma, Neuroendocrine / Q000737:chemistry / Q000473:pathology; D002289:Carcinoma, Non-Small-Cell Lung / Q000737:chemistry / Q000473:pathology*; D002454:Cell Differentiation; D002864:Chromogranins / Q000032:analysis; D006801:Humans; D008175:Lung Neoplasms / Q000737:chemistry / Q000473:pathology*; D009363:Neoplasm Proteins / Q000032:analysis*; D009419:Nerve Tissue Proteins / Q000032:analysis; D018358:Neuroendocrine Tumors / Q000737:chemistry / Q000473:pathology*; D010751:Phosphopyruvate Hydratase / Q000032:analysis; D013869:Thiolester Hydrolases / Q000032:analysis; D043222:Ubiquitin Thiolesterase
D014408:Biomarkers, Tumor; D002864:Chromogranins; D009363:Neoplasm Proteins; D009419:Nerve Tissue Proteins; C081781:RTN1 protein, human; D013869:Thiolester Hydrolases; D043222:Ubiquitin Thiolesterase; D010751:Phosphopyruvate Hydratase