Acupuncture normalizes dysfunction of hypothalamic-pituitary-ovarian axis.
This article summarizes the studies of the mechanism of electroacupuncture (EA) in the regulation of the abnormal function of hypothalamic-pituitary-ovarian axis (HPOA) in our laboratory. Clinical observation showed that EA with the effective acupoints could cure some anovulatory patients in a highly effective rate and the experimental results suggested that EA might regulate the dysfunction of HPOA in several ways, which means EA could influence some gene expression of brain, thereby, normalizing secretion of some hormones, such as GnRH, LH and E2. The effects of EA might possess a relative specificity on acupoints.
Chen
B Y
BY
Institute of Acupuncture, Shanghai Medical University, P.R. China.
D000311:Adrenal Glands / Q000502:physiology; D000818:Animals; D000858:Anovulation / Q000628:therapy; D001921:Brain / Q000378:metabolism; D003345:Corticosterone / Q000097:blood; D015671:Electroacupuncture; D004847:Epithelial Cells / Q000502:physiology; D004958:Estradiol / Q000097:blood; D005260:Female; D015870:Gene Expression; D007987:Gonadotropin-Releasing Hormone / Q000378:metabolism; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology*; D007246:Infertility / Q000628:therapy; D007986:Luteinizing Hormone / Q000097:blood; D010052:Ovariectomy; D010053:Ovary / Q000503:physiopathology*; D011085:Polycystic Ovary Syndrome / Q000503:physiopathology / Q000601:surgery; D016760:Proto-Oncogene Proteins c-fos / Q000235:genetics; D012333:RNA, Messenger / Q000235:genetics; D051381:Rats; D017208:Rats, Wistar; D011960:Receptors, Estrogen / Q000235:genetics; D012741:Sexual Maturation / Q000502:physiology; D014621:Vagina / Q000166:cytology / Q000601:surgery; D001615:beta-Endorphin / Q000097:blood
D016760:Proto-Oncogene Proteins c-fos; D012333:RNA, Messenger; D011960:Receptors, Estrogen; D007987:Gonadotropin-Releasing Hormone; D004958:Estradiol; D001615:beta-Endorphin; D007986:Luteinizing Hormone; D003345:Corticosterone