title: The ubiquitin system.
abstract: Eukaryotes contain a highly conserved multi-enzyme system that covalently links ubiquitin to a variety of intracellular proteins that bear degradation signals recognized by this system. The resulting ubiquitin-protein conjugates are degraded by the 26S proteasome, a large ATP-dependent protease. Pathways that involve ubiquitin underlie a multitude of processes, including cell differentiation, the cell cycle and responses to stress.
authors.affiliation: Division of Biology, California Institute of Technology, Pasadena 91125, USA. avarsh@cco.caltech.edu
authors.forename: A
authors.initials: A
authors.lastname: Varshavsky
mesh_terms: D003546:Cysteine Endopeptidases / Q000737:chemistry; D009097:Multienzyme Complexes / Q000737:chemistry; D046988:Proteasome Endopeptidase Complex; D011506:Proteins / Q000737:chemistry*; D014452:Ubiquitins / Q000737:chemistry*
chemical_list: D009097:Multienzyme Complexes; D011506:Proteins; D014452:Ubiquitins; D003546:Cysteine Endopeptidases; D046988:Proteasome Endopeptidase Complex