Biphasic effects of pu-chung-i-chi-tang on sedation and excitation.
The biphasic effects of Pu-Chung-I-Chi-Tang (PCT) on sedation and excitation in acute treatment or after one-week consecutive treatment were studied. The results indicated that PCT produces sedation in acute treatment and excitation after one-week consecutive treatment. The sedative mechanism of PCT in acute treatment might be due to an increase in serotonergic activity and a decrease in dopaminergic activity. However, the excitatory mechanism of PCT after one-week consecutive treatment might involve the increase in dopaminergic activity and the decrease in serotonergic activity.
Hsieh
M T
MT
Institute of Chinese Pharmaceutical Sciences, China Medical College, Taichung, Taiwan.
Lu
S P
SP
Peng
W H
WH
Chang
K H
KH
Pan
I H
IH
D000818:Animals; D018492:Dopamine Antagonists / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000494:pharmacology*; D006591:Hexobarbital; D006993:Hypnotics and Sedatives / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects*; D051381:Rats; D017207:Rats, Sprague-Dawley; D017366:Serotonin Receptor Agonists / Q000494:pharmacology; D012890:Sleep / Q000187:drug effects*
D018492:Dopamine Antagonists; D004365:Drugs, Chinese Herbal; D006993:Hypnotics and Sedatives; D017366:Serotonin Receptor Agonists; C110111:pu-chung-i-chi-tang; D006591:Hexobarbital