title: The effect of pharmacologic erection on the dorsal nerve of the penis.
abstract: The dorsal nerve of the penis (DNP) is the primary source of afferent somatic input from the penis and is critical in the male sexual functions of erection and ejaculation. Using genitourinary electrodiagnostic techniques, this study was conducted to investigate the effect of pharmacologic erection on the DNP. Three tests were administered, and the changes in the DNP between flaccid, stretched, and erect states were examined. Calculated nerve conduction velocity (cNCV) measurements of the DNP increased with pharmacologic erection because mechanical straightening of the nerve allowed for a more precise measurement of nerve length. The latencies of the cortical evoked response and the bulbocavernosus reflex were not significantly changed with stretch or pharmacologic erection. In the evaluation of impotence, cNCV DNP measurements should be performed on the erect penis.
authors.affiliation: Department of Urology, University of Washington, Seattle 98195, USA.
authors.forename: C C
authors.initials: CC
authors.lastname: Yang
authors.forename: W E
authors.initials: WE
authors.lastname: Bradley
authors.forename: R E
authors.initials: RE
authors.lastname: Berger
mesh_terms: D000328:Adult; D005071:Evoked Potentials; D006801:Humans; D008297:Male; D009424:Nervous System Physiological Phenomena; D009431:Neural Conduction; D010208:Papaverine / Q000494:pharmacology; D010410:Penile Erection / Q000502:physiology*; D010413:Penis / Q000187:drug effects / Q000294:innervation* / Q000502:physiology; D010646:Phentolamine / Q000494:pharmacology; D012018:Reflex / Q000502:physiology; D013268:Stimulation, Chemical; D013997:Time Factors; D014665:Vasodilator Agents / Q000494:pharmacology
chemical_list: D014665:Vasodilator Agents; D010208:Papaverine; D010646:Phentolamine