ApoE genotype and Alzheimer's disease in adults with Down syndrome: meta-analysis.
The apoE gene polymorphism was examined in 100 adults with Down syndrome (with and without dementia) compared to 346 control subjects without mental retardation. Meta-analysis of available data (480 subjects) revealed that apolipoprotein E genotype distribution for people with Down syndrome was similar to that of the nonretarded population. Although no significant association between possession of the apoE epsilon 4 allele and onset of Alzheimer's disease was found, subjects with the allele had a tendency towards lower age of onset of dementia. Subjects with apoE epsilon 2 allele may not develop dementia and may have increased longevity.
Prasher
V P
VP
University of Birmingham, Queen Elizabeth Hospital, Birmingham, United Kingdom.
Chowdhury
T A
TA
Rowe
B R
BR
Bain
S C
SC
D000328:Adult; D000368:Aged; D000483:Alleles; D000544:Alzheimer Disease / Q000150:complications* / Q000235:genetics*; D001057:Apolipoproteins E / Q000235:genetics*; D004314:Down Syndrome / Q000150:complications*; D005260:Female; D005838:Genotype; D006801:Humans; D008136:Longevity; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic
D001057:Apolipoproteins E