Glutamatergic system and developmental lead neurotoxicity.
The excitatory amino acid receptor subtype N-Methyl-D-Aspartate (NMDA) has been the focus of intense investigation during the last decade because of its role in brain development and synaptic plasticity and in pathological conditions associated with excitotoxicity. This receptor complex has recently been identified to be a target for lead (Pb2+) effects on the developing central nervous system. This presentation is an overview of studies demonstrating the interaction of Pb2+ with the NMDA receptor and its potential effects on cellular function and cognition.
Guilarte
T R
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Department of Environmental Health Sciences, The Johns Hopkins University, School of Hygiene and Public Health, Baltimore, Maryland 21205, U.S.A.
D000818:Animals; D005260:Female; D007854:Lead / Q000633:toxicity*; D018811:Maternal Exposure; D009498:Neurotoxins / Q000633:toxicity*; D016194:Receptors, N-Methyl-D-Aspartate / Q000187:drug effects*
D009498:Neurotoxins; D016194:Receptors, N-Methyl-D-Aspartate; D007854:Lead