Identifying neuronal non-L Ca2+ channels--more than stamp collecting?
The pharmacology of the majority of Ca2+ channels in the nervous system is very limited. Although attempts have been made to constrain native Ca2+ channels into the framework provided by the six pore-forming molecules cloned to date, refined biophysical analysis of Ca2+ currents, expression techniques and the use of selective toxins have helped to identify unambiguously only a limited number of Ca2+ channels. In fact, many native Ca2+ channel activities remain as 'orphans', waiting for their molecular counterparts to be defined. In this article, Janet Nooney, Régis Lambert and Anne Feltz systematically delineate the well characterized non-L Ca2+ channel activities and the missing elements in our knowledge of the Ca2+ channel family.
Nooney
J M
JM
Department of Pharmacology, University of Edinburgh, UK.
Lambert
R C
RC
Feltz
A
A
D000595:Amino Acid Sequence; D000818:Animals; D015220:Calcium Channels / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D008969:Molecular Sequence Data; D009474:Neurons / Q000187:drug effects / Q000378:metabolism*
D015220:Calcium Channels