title: Levels of serum tumor necrosis factor alpha in relation to clinical involvement and treatment among Thai adults with Plasmodium falciparum malaria.
abstract: Concentrations of tumor necrosis factor alpha (TNF-alpha) in serum were measured in 17 Thai men infected with Plasmodium falciparum malarial infections to determine whether they were affected by severity of infections or exchange transfusions. Twelve patients were considered having complicated malarial infections, eight of whom had cerebral malaria. Five patients had uncomplicated malarial infections. The results showed that malarial infection markedly raised TNF-alpha level above normal values (mean +/- SEM 406 +/- 38 vs 15 +/- 5, p = 0.004). In complicated malaria, cerebral involvement appeared to significantly increase concentration of TNF-alpha when compared to values in uncomplicated malaria (mean +/- SEM 496 +/- 64 vs 339 +/- 12, p = 0.01). Degree of parasitemia, intravenous quinine (day 0 value vs day 7 value) and exchange transfusion did not significantly affect TNF-alpha levels.
  
  
  CONCLUSIONS
  Serum level of TNF-alpha is increased in Plasmodium falciparum malarial infections and may be a useful index to predict severity of malarial infection, cerebral malaria in particular.
authors.affiliation: Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
authors.forename: S
authors.initials: S
authors.lastname: Chuncharunee
authors.forename: S
authors.initials: S
authors.lastname: Jootar
authors.forename: A
authors.initials: A
authors.lastname: Leelasiri
authors.forename: N
authors.initials: N
authors.lastname: Archararit
authors.forename: W
authors.initials: W
authors.lastname: Prayoonwiwat
authors.forename: W
authors.initials: W
authors.lastname: Mongkonsritragoon
authors.forename: P
authors.initials: P
authors.lastname: Polvicha
authors.forename: T
authors.initials: T
authors.lastname: Srichaikul
mesh_terms: D000328:Adult; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D016779:Malaria, Cerebral / Q000150:complications; D016778:Malaria, Falciparum / Q000097:blood* / Q000150:complications; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D013785:Thailand; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis*
chemical_list: D014409:Tumor Necrosis Factor-alpha