DNA recognition and bending.
DNA-binding proteins recognize their DNA targets not only through the formation of specific contacts with the nucleotide bases but also through inherent properties of the DNA sequence, including increased bendability and rigidity. Consideration of the properties of both the protein and the DNA is required before the sequence specificity and the observed DNA bend in DNA-protein complexes can be understood.
Allemann
R K
RK
Department of Chemistry, ETH-Zurich, Switzerland. allemann@chem.ethz.ch
Egli
M
M
D000818:Animals; D004247:DNA / Q000737:chemistry* / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000737:chemistry*; D006801:Humans; D009690:Nucleic Acid Conformation; D013329:Structure-Activity Relationship
D004268:DNA-Binding Proteins; D004247:DNA