Solitary extramedullary plasmacytoma five years after successful cardiac transplantation: case report and review of the literature.
We document the occurrence of a solitary extramedullary plasmacytoma (SEP) in a cardiac transplant patient. The diagnosis of plasma cell malignancy was confirmed by histopathologic and immunohistochemical examination of a nodular skin lesion. A complete systemic evaluation showed no evidence of metastatic disease. The patient was treated locally with radiation therapy (RT), but disseminated multiple myeloma developed 4 months after diagnosis. A variety of tumors have been reported to develop in the cardiac or renal transplant recipient, although plasma cell malignancies are rare. To our knowledge, this is the first reported case of an SEP in an organ transplant recipient.
Leigh
B R
BR
Department of Radiation Oncology, University of California, Davis Cancer Center, Sacramento 95817-2229, USA.
Larkin
E C
EC
Doggett
R L
RL
D002467:Cell Nucleus / Q000648:ultrastructure; D017809:Fatal Outcome; D005500:Follow-Up Studies; D016027:Heart Transplantation; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007145:Immunoglobulin kappa-Chains / Q000032:analysis; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000473:pathology; D010950:Plasma Cells / Q000473:pathology; D010954:Plasmacytoma / Q000473:pathology* / Q000532:radiotherapy; D011882:Radiotherapy, High-Energy; D012074:Remission Induction; D012878:Skin Neoplasms / Q000473:pathology* / Q000532:radiotherapy
D007074:Immunoglobulin G; D007145:Immunoglobulin kappa-Chains