Assemblin, an essential herpesvirus proteinase.
The herpesvirus maturational proteinase, called assemblin, is essential for the production of infectious virus and represents a new molecular target for the development of antivirals. A brief summary of the synthesis, structure, and function of this fascinating enzyme is presented here.
Gibson
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Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA. Wade_Gibson@qmail.bs.jhu.edu
Hall
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D000818:Animals; D000998:Antiviral Agents; D010450:Endopeptidases / Q000737:chemistry* / Q000235:genetics* / Q000502:physiology; D006564:Herpesviridae / Q000201:enzymology*; D006801:Humans; D012697:Serine Endopeptidases; D019065:Virus Assembly / Q000502:physiology
D000998:Antiviral Agents; D010450:Endopeptidases; D012697:Serine Endopeptidases; C071910:assemblin