Factors influencing MAC reduction after cardiopulmonary bypass in dogs.
BACKGROUND
Anaesthetic requirements may be reduced following surgery employing cardiopulmonary bypass (CPB). This study, in dogs, determined the role of a) volatile agents (enflurane [E] vs isoflurane [I]), b) oxygenator (bubble [B] vs membrane [M]), and c) presence [FL] vs absence [NoFL] of an in-line arterial filter in the bypass circuit in altering anaesthetic requirements following CPB.


METHODS
Male mongrel dogs were anaesthetized with either enflurane (n = 24) or isoflurane (n = 24). They were randomly assigned to one of eight groups (n = 6 per group); Group 1 (E/B/FL), Group 2 (E/M/FL), Group 3 (E/M/NoFL), Group 4 (E/B/NoFL), Group 5 (I/M/FL), Group 6 (I/B/FL), Group 7 (I/M/NoFL) or Group 8 (I/B/NoFL). MAC was determined using the tail-clamp method at hourly intervals, twice before and three times after a one hour normothermic perfusion using aortoatrial cannulation and CPB.


RESULTS
Prior to CPB, MAC was reproducible (enflurane: MAC1 2.17 +/- 0.29 vs MAC2 2.14 +/- 0.28%; isoflurane: MAC1 1.42 +/- 0.31 vs MAC2 1.41 +/- 0.33%) and differed among groups only for the volatile agent employed. Following CPB, MAC was reduced in all groups (P < 0.05 vs pre-CPB measurements) except Group 1 (E/B/FL). The degree of MAC reduction in other groups ranged from 39-64% and was not different based on type of agent employed, use of a membrane or bubble oxygenator, or presence or absence of an in-line arterial filter.


CONCLUSIONS
In dogs, MAC reduction following CPB was variable, not related to type of volatile agent employed, use of a membrane or bubble oxygenator, or presence or absence of an in-line arterial filter. The explanation for reductions in anaesthetic requirements following CPB in this model remains speculative.
Neumeister
M W
MW
Department of Anaesthesia, Dalhousie University, Halifax, Nova Scotia, Canada.
Li
G
G
Williams
G
G
Doak
G
G
Sullivan
J A
JA
Hall
R I
RI
D000777:Anesthetics / Q000493:pharmacokinetics*; D018685:Anesthetics, Inhalation / Q000493:pharmacokinetics; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002315:Cardiopulmonary Bypass; D004285:Dogs; D004737:Enflurane / Q000493:pharmacokinetics; D007530:Isoflurane / Q000493:pharmacokinetics; D008297:Male; D010101:Oxygen Consumption / Q000187:drug effects / Q000502:physiology; D011650:Pulmonary Alveoli / Q000378:metabolism*; D013997:Time Factors
D000777:Anesthetics; D018685:Anesthetics, Inhalation; D004737:Enflurane; D007530:Isoflurane