title: Protective immunity against respiratory syncytial virus in early life after murine maternal or neonatal vaccination with the recombinant G fusion protein BBG2Na.
abstract: Maternal and neonatal immunization were evaluated for their capacity to induce protective immunity against respiratory syncytial virus (RSV) lower respiratory tract infections in early life. Murine models were studied by use of a novel recombinant vaccine candidate, designated BBG2Na, which was derived in part from the RSV (Long) G protein. Maternal immunization resulted in the passive transfer of high levels of RSV-A antibodies to the offspring, which protected them from RSV challenge for up to 14 weeks. Indeed, protection correlated with the detection of RSV antibodies in the serum. Neonatal immunization with BBG2Na induced significant antibody responses even in the first week of life. Most importantly, these neonatal responses were not inhibited by the presence of RSV maternal antibodies. Consequently, the combination of maternal and neonatal immunization with BBG2Na resulted in the continual presence of protective levels of antibodies in the offspring.
authors.affiliation: World Health Organization Collaborating Center for Neonatal Vaccinology, Department of Pathology, University of Geneva, Switzerland.
authors.forename: C
authors.initials: C
authors.lastname: Brandt
authors.forename: U F
authors.initials: UF
authors.lastname: Power
authors.forename: H
authors.initials: H
authors.lastname: Plotnicky-Gilquin
authors.forename: T
authors.initials: T
authors.lastname: Huss
authors.forename: T
authors.initials: T
authors.lastname: Nguyen
authors.forename: P H
authors.initials: PH
authors.lastname: Lambert
authors.forename: H
authors.initials: H
authors.lastname: Binz
authors.forename: C A
authors.initials: CA
authors.lastname: Siegrist
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis / Q000276:immunology; D007110:Immunity, Active; D007112:Immunity, Maternally-Acquired; D051379:Mice; D008807:Mice, Inbred BALB C; D018448:Models, Immunological; D018357:Respiratory Syncytial Virus Infections / Q000276:immunology* / Q000517:prevention & control; D018113:Respiratory Syncytial Virus, Human / Q000276:immunology; D013047:Specific Pathogen-Free Organisms; D014611:Vaccination; D014614:Vaccines, Synthetic / Q000008:administration & dosage* / Q000276:immunology*; D014764:Viral Proteins / Q000276:immunology
chemical_list: D000914:Antibodies, Viral; D014614:Vaccines, Synthetic; D014764:Viral Proteins