New and potent inhibitors of nitric oxide synthase reduce motor activity in mice.
Potent inhibitors of nitric oxide synthase (NOS), 3-bromo-7-nitro indazole, 1-(2-trifluoromethylphenyl)imidazole, S-methyl-L-thiocitrulline and 7-nitro indazole, reduced locomotion in mice. These results suggest that activity of NOS and corresponding NO release are of importance for normal locomotion.
Dzoljic
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Department of Pharmacology, Faculty of Medicine and Health Sciences, Erasmus University Rotterdam, The Netherlands.
De Vries
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R
Dzoljic
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MR
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000502:physiology; D004569:Electroencephalography / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000494:pharmacology; D008124:Locomotion / Q000187:drug effects / Q000502:physiology; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology*; D019001:Nitric Oxide Synthase / Q000187:drug effects / Q000502:physiology*
D004791:Enzyme Inhibitors; D019001:Nitric Oxide Synthase