title: Brain activity assessed with PET during recall of word lists and narratives.
abstract: This study investigated the functional neuroanatomy involved in retrieval of structured versus unstructured verbal information. We compared cerebral blood flow using PET with the [15O]water method while subjects engaged in recall of novel and practised narratives and lists of unrelated words. Left orbital frontal cortex was activated during recall of both novel and practised unrelated words. Right parietal cortex was relatively more active during recall of the novel word list. Right orbital frontal cortex and anterior cingulate were relatively more active during recall of the practised but not the novel word list. These results are consistent with the role of left orbital frontal cortex in retrieval of unstructured verbal information. Right orbital frontal activity suggests that cognitive strategies may be involved in retrieval of well-practised words.
authors.affiliation: Department of Psychiatry Administration, University of Iowa College of Medicine, Iowa City 52242, USA.
authors.forename: S
authors.initials: S
authors.lastname: Paradiso
authors.forename: B
authors.initials: B
authors.lastname: Crespo Facorro
authors.forename: N C
authors.initials: NC
authors.lastname: Andreasen
authors.forename: D S
authors.initials: DS
authors.lastname: O'Leary
authors.forename: L G
authors.initials: LG
authors.lastname: Watkins
authors.forename: L
authors.initials: L
authors.lastname: Boles Ponto
authors.forename: R D
authors.initials: RD
authors.lastname: Hichwa
mesh_terms: D000328:Adult; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D008297:Male; D011939:Mental Recall; D012016:Reference Values; D014055:Tomography, Emission-Computed; D014706:Verbal Learning / Q000502:physiology*