title: Intratumoral microdistribution of [131I]MB-1 in patients with B-cell lymphoma following radioimmunotherapy.
abstract: Intratumoral microdistribution of radiolabeled anti-CD37 murine monoclonal antibody, [131I]MB-1, in lymph nodes from five patients with non-Hodgkin's B-cell lymphoma following radioimmunotherapy were evaluated by microautoradiography and image analysis of macroautoradiographs. Microdistribution of radioactivity was highly heterogeneous: silver grain counts varied from 28-70 to 8-10 per 400 X field, and the coefficients of variations calculated by image analysis ranged between 42.5 and 79.3%. Variable radiation doses delivered could have contributed to the limited durability of tumor regression.
authors.affiliation: Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor 48109-0028, USA.
authors.forename: R S
authors.initials: RS
authors.lastname: Brown
authors.forename: M S
authors.initials: MS
authors.lastname: Kaminski
authors.forename: S J
authors.initials: SJ
authors.lastname: Fisher
authors.forename: A E
authors.initials: AE
authors.lastname: Chang
authors.forename: R L
authors.initials: RL
authors.lastname: Wahl
mesh_terms: D000911:Antibodies, Monoclonal / Q000493:pharmacokinetics*; D001345:Autoradiography; D017321:Clinical Trials, Phase I as Topic; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007150:Immunohistochemistry; D007457:Iodine Radioisotopes; D007553:Isotope Labeling; D008198:Lymph Nodes / Q000000981:diagnostic imaging / Q000473:pathology; D016393:Lymphoma, B-Cell / Q000378:metabolism* / Q000473:pathology / Q000628:therapy*; D016499:Radioimmunotherapy / Q000379:methods*; D011877:Radionuclide Imaging; D016622:Silver Staining
chemical_list: D000911:Antibodies, Monoclonal; D007457:Iodine Radioisotopes