Protective genes expressed in endothelial cells: a regulatory response to injury.
Endothelial cells (ECs) have evolved to guard against insults that incite inflammation. Response to injury is an active process that, if uncontrolled, can progress to EC death (apoptosis). Here Fritz Bach and colleagues suggest that ECs have a balancing component to their proinflammatory response: they upregulate a set of protective genes, including anti-apoptotic genes, that serve to limit the activation process and thereby regulate the response to injury.
Bach
F H
FH
Sandoz Center for Immunobiology, Dept. of Surgery, Boston, MA, USA.
Hancock
W W
WW
Ferran
C
C
D000818:Animals; D017209:Apoptosis / Q000235:genetics; D004727:Endothelium / Q000276:immunology* / Q000293:injuries / Q000378:metabolism; D015870:Gene Expression; D006084:Graft Rejection; D006085:Graft Survival; D006801:Humans; D007249:Inflammation / Q000209:etiology; D008954:Models, Biological; D016328:NF-kappa B / Q000378:metabolism; D014183:Transplantation, Heterologous
D016328:NF-kappa B