Eukaryotic protein secretion.
The components responsible for protein translocation across the endoplasmic reticulum membrane have been identified and their functions have been clarified in vitro. The structural features of the signal peptide specify the factors and pathways of membrane translocation. Various chaperones and folding enzymes are involved in the folding and quality control of secretory proteins in the lumen.
Sakaguchi
M
M
Department of Molecular Biology, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan. sakag@cell.med.kyushu-u.ac.jp
D000818:Animals; D001709:Biotechnology / Q000379:methods; D003001:Cloning, Molecular / Q000379:methods; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D004798:Enzymes / Q000096:biosynthesis* / Q000737:chemistry; D018014:Gene Transfer Techniques; D006801:Humans; D018832:Molecular Chaperones / Q000502:physiology; D017510:Protein Folding; D011499:Protein Processing, Post-Translational; D021382:Protein Sorting Signals; D011994:Recombinant Proteins / Q000096:biosynthesis* / Q000737:chemistry
D004798:Enzymes; D018832:Molecular Chaperones; D021382:Protein Sorting Signals; D011994:Recombinant Proteins