title: Fat embolism syndrome.
abstract: Fat embolism syndrome, an important contributor to the development of acute respiratory distress syndrome, has been associated with both traumatic and nontraumatic disorders. Fat embolization after long bone trauma is probably common as a subclinical event. Fat emboli can deform and pass through the lungs, resulting in systemic embolization, most commonly to the brain and kidneys. The diagnosis of fat embolism syndrome is based on the patient's history, supported by clinical-signs of pulmonary, cerebral and cutaneous dysfunction and confirmed by the demonstration of arterial hypoxemia in the absence of other disorders. Treatment of fat embolism syndrome consists of general supportive measures, including splinting, maintenance of fluid and electrolyte balance and the administration of oxygen. Endotracheal intubation and mechanical ventilatory assistance can be indicated. The role of corticosteroids remains controversial. Early stabilization of long bone fractures has been shown to decrease the incidence of pulmonary complications. Clinical and experimental studies suggest that the exact method of fracture fixation plays a minor role in the development of pulmonary dysfunction. As more is learned about the specifics of the various triggers for the development of fat embolism syndrome, it is hoped that the prospect of more specific therapy for the prevention and treatment of this disorder will become a reality.
authors.affiliation: Department of Surgery, St. Michael's Hospital, Toronto, Ont.
authors.forename: R R
authors.initials: RR
authors.lastname: Richards
mesh_terms: D003937:Diagnosis, Differential; D004620:Embolism, Fat / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D005592:Fracture Fixation / Q000379:methods; D050723:Fractures, Bone / Q000150:complications; D006801:Humans; D000860:Hypoxia / Q000209:etiology; D015995:Prevalence; D012128:Respiratory Distress Syndrome / Q000209:etiology