title: Early experience with intravenous immunoglobulin treatment in Wegener's granulomatosis with ocular involvement.
abstract: BACKGROUND
  Pooled intravenous gammaglobulin (IVIg) was reported to be effective in the treatment of Wegener's granulomatosis (WG). No reports have been made on the effects of this new treatment on ocular manifestations of WG.
  
  
  METHODS
  IVIg treatment was given to two patients suffering from WG with ocular involvement after several other treatment regimes had failed.
  
  
  RESULTS
  Although the systemic disease was under control, the ocular symptoms of both patients worsened during and after IVIg treatment. In one case an adverse effect consisting of retinal vasculitis was noted on two occasions.
  
  
  CONCLUSIONS
  Although beneficial effects of IVIg treatment on WG have been previously described, the two cases with ocular involvement presented here did not reveal any positive response. Paradoxical and unpredictable reactions cannot be ruled out. Thus, patients treated with IVIg should be closely surveyed by an ophthalmologist.
authors.affiliation: Department of Ophthalmology, University of Heidelberg, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Blum
authors.forename: K
authors.initials: K
authors.lastname: Andrassy
authors.forename: D
authors.initials: D
authors.lastname: Adler
authors.forename: M
authors.initials: M
authors.lastname: Hartmann
authors.forename: H E
authors.initials: HE
authors.lastname: Völcker
mesh_terms: D000328:Adult; D000368:Aged; D005128:Eye Diseases / Q000150:complications / Q000175:diagnosis / Q000628:therapy*; D005260:Female; D005500:Follow-Up Studies; D014890:Granulomatosis with Polyangiitis / Q000150:complications / Q000175:diagnosis / Q000628:therapy*; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000009:adverse effects / Q000627:therapeutic use*; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008279:Magnetic Resonance Imaging; D008297:Male; D012008:Recurrence; D012164:Retinal Diseases / Q000139:chemically induced / Q000473:pathology; D012171:Retinal Vessels / Q000187:drug effects / Q000473:pathology; D014057:Tomography, X-Ray Computed; D014657:Vasculitis / Q000139:chemically induced
chemical_list: D016756:Immunoglobulins, Intravenous; D007166:Immunosuppressive Agents