Renal osmoregulatory transport of compatible organic osmolytes.
Cells in renal medullas are exposed to a high concentration of salt during antidiuresis. They adapt in part by accumulating myo-inositol, glycine betaine, taurine, and other amino acids by transporting them from the interstitial fluid. This transport is osmotically regulated by changes in transcription of the transporters and by post-translational modifications. Most of the original studies were in vitro, but these processes are increasingly being examined in vivo.
Burg
M B
MB
National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892-1603, USA. maurice_burg@NIH.gov
D000818:Animals; D001692:Biological Transport; D006801:Humans; D007294:Inositol / Q000378:metabolism*; D007679:Kidney Medulla / Q000378:metabolism*; D009994:Osmolar Concentration
D007294:Inositol