title: Laryngeal necrosis after combined chemotherapy and radiation therapy.
abstract: Post-radiation necrosis of the larynx is a major complication after irradiation and has become rare. Recently, combined chemotherapy and radiation therapy has been introduced for head and neck tumours. The authors report a case of laryngeal necrosis after combination therapy for a patient with cervical lymph node metastases of nasopharyngeal carcinoma and review the literature on late laryngeal necrosis. Although radiation-induced laryngeal necrosis has become a rare complication, the combination of chemotherapy and radiation therapy may increase its incidence. We should always consider it as a possible late complication and treat it appropriately.
authors.affiliation: Department of Otorhinolaryngology, Osaka University School of Medicine, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Miyaguchi
authors.forename: H
authors.initials: H
authors.lastname: Takashima
authors.forename: T
authors.initials: T
authors.lastname: Kubo
mesh_terms: D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000532:radiotherapy; D003131:Combined Modality Therapy; D006801:Humans; D007817:Laryngeal Cartilages / Q000187:drug effects / Q000473:pathology* / Q000528:radiation effects; D008297:Male; D009303:Nasopharyngeal Neoplasms / Q000188:drug therapy / Q000532:radiotherapy; D011832:Radiation Injuries / Q000473:pathology; D011878:Radiotherapy / Q000009:adverse effects*; D013997:Time Factors