Genotoxic effects of poly-D-lysine in m-AMSA (amsacrine) treated Chinese hamster ovary (CHO) cells.
Cultured Chinese hamster ovary (CHO) cells were pre-treated with m-AMSA (amsacrine) and post-treated with different doses of polycationic compound poly-D-lysine (PDL) during G2 period in order to test on the frequency of chromatid-type aberrations. The present results indicate that PDL enhances the genotoxic action of m-AMSA measured as induced chromatid aberrations.
Panneerselvam
N
N
SPK Centre for Environmental Sciences, Manonmaniam Sundaranar University, Tirunelveli, India.
D000677:Amsacrine / Q000494:pharmacology*; D000818:Animals; D016466:CHO Cells; D006224:Cricetinae; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D009153:Mutagens / Q000494:pharmacology*; D011107:Polylysine / Q000494:pharmacology*; D059005:Topoisomerase II Inhibitors
D004791:Enzyme Inhibitors; D009153:Mutagens; D059005:Topoisomerase II Inhibitors; D000677:Amsacrine; D011107:Polylysine