title: Dibasic benzo[b]thiophene derivatives as a novel class of active site-directed thrombin inhibitors. 1. Determination of the serine protease selectivity, structure-activity relationships, and binding orientation.
authors.affiliation: Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA.
authors.forename: D J
authors.initials: DJ
authors.lastname: Sall
authors.forename: J A
authors.initials: JA
authors.lastname: Bastian
authors.forename: S L
authors.initials: SL
authors.lastname: Briggs
authors.forename: J A
authors.initials: JA
authors.lastname: Buben
authors.forename: N Y
authors.initials: NY
authors.lastname: Chirgadze
authors.forename: D K
authors.initials: DK
authors.lastname: Clawson
authors.forename: M L
authors.initials: ML
authors.lastname: Denney
authors.forename: D D
authors.initials: DD
authors.lastname: Giera
authors.forename: D S
authors.initials: DS
authors.lastname: Gifford-Moore
authors.forename: R W
authors.initials: RW
authors.lastname: Harper
authors.forename: K L
authors.initials: KL
authors.lastname: Hauser
authors.forename: V J
authors.initials: VJ
authors.lastname: Klimkowski
authors.forename: T J
authors.initials: TJ
authors.lastname: Kohn
authors.forename: H S
authors.initials: HS
authors.lastname: Lin
authors.forename: J R
authors.initials: JR
authors.lastname: McCowan
authors.forename: A D
authors.initials: AD
authors.lastname: Palkowitz
authors.forename: G F
authors.initials: GF
authors.lastname: Smith
authors.forename: K
authors.initials: K
authors.lastname: Takeuchi
authors.forename: K J
authors.initials: KJ
authors.lastname: Thrasher
authors.forename: J M
authors.initials: JM
authors.lastname: Tinsley
authors.forename: B G
authors.initials: BG
authors.lastname: Utterback
authors.forename: S C
authors.initials: SC
authors.lastname: Yan
authors.forename: M
authors.initials: M
authors.lastname: Zhang
mesh_terms: D000818:Animals; D001665:Binding Sites; D018360:Crystallography, X-Ray; D006801:Humans; D015842:Serine Proteinase Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013876:Thiophenes / Q000737:chemistry / Q000494:pharmacology*; D013917:Thrombin / Q000037:antagonists & inhibitors*
chemical_list: D015842:Serine Proteinase Inhibitors; D013876:Thiophenes; C088015:benzothiophene; D013917:Thrombin