title: Relapse of acute leukemia in childhood presenting as proptosis due to an orbital mass.
abstract: Extramedullary relapse of acute leukemia in sites outside the central nervous system or testes is rare. We report two children who developed proptosis due to an orbital mass as the initial presentation of leukemic relapse. The first patient was an 11-year-old girl with acute myelogenous leukemia who had undergone bone marrow transplantation 4 years previously. She had been in remission until 2 months prior to the present admission, when she developed isolated relapse of disease in the left orbit. The second patient, an 11-year-old girl with acute lymphoblastic leukemia, had been off chemotherapy for 2 years and in remission for 5 years. She suffered from concurrent orbital and central nervous system relapse. Both patients were treated with systemic chemotherapy and orbital radiotherapy. More than 1 year after the relapse, the proptosis was completely cured in both patients.
authors.affiliation: Department of Ophthalmology, Provincial Taoyuan Hospital, Taiwan, ROC.
authors.forename: L Y
authors.initials: LY
authors.lastname: Hsu
authors.forename: J R
authors.initials: JR
authors.lastname: Jou
authors.forename: H S
authors.initials: HS
authors.lastname: Tseng
authors.forename: C
authors.initials: C
authors.lastname: Shiue
authors.forename: P K
authors.initials: PK
authors.lastname: Hou
authors.forename: K H
authors.initials: KH
authors.lastname: Lin
mesh_terms: D002648:Child; D005094:Exophthalmos / Q000209:etiology*; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000150:complications*; D009918:Orbital Neoplasms / Q000150:complications*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications*; D012008:Recurrence