title: Incidence of Barrett's adenocarcinoma in an Italian population: an endoscopic surveillance programme. Gruppo Operativo per lo Studio delle Precancerosi Esofagee (GOSPE).
abstract: BACKGROUND
  Barrett's oesophagus is a premalignant condition leading to adenocarcinoma. The incidence of adenocarcinoma of the oesophagus and the gastrooesophageal junction is rapidly increasing in the USA, northern and central Europe. Data from southern Europe are still unavailable.
  
  
  OBJECTIVE
  To evaluate the incidence of oesophageal adenocarcinoma in a large cohort of Italian patients with Barrett's oesophagus.
  
  
  METHODS
  A total of 344 patients (253 males and 91 females, age range 19-75 years) with histologically proven Barrett's oesophagus (length of metaplasia > or = 3 cm) were enrolled from November 1987 to June 1995. Endoscopic and histological examinations were scheduled at yearly intervals.
  
  
  RESULTS
  One hundred and eighty-seven patients complied with the follow-up. The mean duration of the follow-up period was 36 months (total follow-up 562 patient-years; range 12-90 months). Low grade dysplasia was found in five patients at the initial examination. During the surveillance period, dysplasia increased in frequency as well as in severity and was found exclusively in the intestinal type of Barrett's oesophagus. In all, dysplastic changes were found in seven patients (five low grade and two high grade) and adenocarcinoma developed in three patients during the follow-up. In a single case, both adenocarcinoma and specialized columnar epithelium developed without any evidence of dysplasia or intestinal metaplasia at the previous follow-up examination. This prospective study shows an incidence of adenocarcinoma in Barrett's oesophagus of 1/187 patient-years. When only patients with specialized columnar epithelium were considered, the risk of adenocarcinoma was 1/88 patient-years.
  
  
  CONCLUSIONS
  The present report shows that the incidence of adenocarcinoma in Italian Barrett's oesophagus patients is in the range of that reported from other Western countries.
authors.affiliation: Divisione di Gastroenterologia ed Endoscopia Digestiva, Ospedale Mauriziano Umberto I, Turin, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Ferraris
authors.forename: L
authors.initials: L
authors.lastname: Bonelli
authors.forename: M
authors.initials: M
authors.lastname: Conio
authors.forename: M
authors.initials: M
authors.lastname: Fracchia
authors.forename: G
authors.initials: G
authors.lastname: Lapertosa
authors.forename: H
authors.initials: H
authors.lastname: Aste
mesh_terms: D000230:Adenocarcinoma / Q000453:epidemiology*; D000328:Adult; D000368:Aged; D001471:Barrett Esophagus / Q000453:epidemiology*; D015331:Cohort Studies; D004724:Endoscopy; D004938:Esophageal Neoplasms / Q000453:epidemiology*; D005260:Female; D006801:Humans; D007558:Italy; D008297:Male; D008403:Mass Screening; D008875:Middle Aged; D011446:Prospective Studies