Laurencia rigida: chemical investigations of its antifouling dichloromethane extract.
From the CH2Cl2 extract of the temperate marine red alga, Laurencia rigida, which has antifouling properties, eight sesquiterpenes (1-8) were isolated. Of these, four (3-acetoxy-E-gamma-bisabolene (1), (-)-10 alpha-bromo-9 beta-hydroxy-alpha-chamigrene (2), rigidol (3), and (+)-(10S)-10-bromo-beta-chamigrene (4)), were shown to be new natural products. For the known compound deschloroelatol (5), reassignment of the 1H- and 13C-NMR data was found to be necessary on the basis of extensive NMR measurements. For elatol (6), complete 1H- and 13C-NMR data are also reported. The antimicrobial and antialgal activities of all isolates were assessed.
König
G M
GM
Department of Pharmaceutical Biology, Technical University of Braunschweig, Germany. g.koenig@tu-bs.de
Wright
A D
AD
D001419:Bacteria / Q000187:drug effects; D002725:Chloroform; D056890:Eukaryota / Q000187:drug effects / Q000502:physiology; D005658:Fungi / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008387:Marine Toxins / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D000461:Rhodophyta / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D014020:Tissue Extracts / Q000737:chemistry / Q000494:pharmacology
D008387:Marine Toxins; D012717:Sesquiterpenes; D014020:Tissue Extracts; D002725:Chloroform