title: Desensitisation of substance P decreases the contractile effect of M15 and Gal (1-14)-(Abu 8) SCY-I on the rat gastric fundus.
abstract: Tachyphylaxis to SP decreased the effect of M15 and Gal(1-14)-[Abu8]SCY-I on gastric smooth muscles, without effect on the action of Gal. These findings support our initial hypothesis: the action of M15 and Gal(1-14)-[Abu8]SCY-I on the smooth muscles may not only be due to their agonist activity at Gal receptors, but may result from a subsequent stimulation of receptors for SP and perhaps for other tachykinins as well, however, a possibility that Gal analogues release endogenous SP can not be excluded. Further studies involving a tachykinin antagonist (spantide) are in progress at the moment. [1].
authors.affiliation: Department of Pharmacology, Medical University of Gdansk, Poland.
authors.forename: R
authors.initials: R
authors.lastname: Korolkiewicz
authors.forename: W
authors.initials: W
authors.lastname: Sliwinski
authors.forename: P
authors.initials: P
authors.lastname: Rekowski
authors.forename: A
authors.initials: A
authors.lastname: Halama
authors.forename: A
authors.initials: A
authors.lastname: Szczurowicz
authors.forename: K Z
authors.initials: KZ
authors.lastname: Korolkiewicz
mesh_terms: D000818:Animals; D019004:Galanin / Q000031:analogs & derivatives* / Q000494:pharmacology*; D005748:Gastric Fundus / Q000187:drug effects; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects*; D064729:Neurokinin-1 Receptor Antagonists; D051381:Rats; D017208:Rats, Wistar; D013373:Substance P / Q000031:analogs & derivatives* / Q000494:pharmacology; D015320:Tachykinins / Q000494:pharmacology*; D013618:Tachyphylaxis / Q000502:physiology
chemical_list: D064729:Neurokinin-1 Receptor Antagonists; D015320:Tachykinins; C109871:gal (1-14)-(Abu 8) scy-I; C074975:galantide; D013373:Substance P; D019004:Galanin