title: The reaction to nailing or cementing of the femur in rats. A microangiographic and fluorescence study.
abstract: Bone reaction to cement and to a cementless stem was studied in the rat femur with histological fluorescence and microangiographic techniques. Periosteal and endosteal apposition, and consequent remodelling, appeared as a reaction to reaming rather than caused by cement or a cementless stem. Every change in bone began with proliferation, progression and orientation of the vessels. Endosteal apposition was absent in cemented femurs because the entire medulla was occupied by the acrylic cement, but remodelling of the subendosteal cortex followed medullary revascularisation which was far advanced after 90 days. In cementless stems, endosteal apposition of primary woven bone and remodelling was the basis for bony ingrowth and anchorage through bony bridges. Our results suggest that the pattern of blood supply is relevant to the structural organisation of mature lamellar bone around the implant. Cemented stems have maximum anchorage and stability as soon as they are inserted, but this decreases with time as revascularisation occurs. Cementless stems can reach maximum integration later after insertion, and revascularisation is less critical because they usually do not fill the canal completely.
authors.affiliation: Facoltà di Medicina e Chirurgia, Università di Brescia, Italy.
authors.forename: U E
authors.initials: UE
authors.lastname: Pazzaglia
authors.forename: L
authors.initials: L
authors.lastname: Andrini
authors.forename: A
authors.initials: A
authors.lastname: Di Nucci
mesh_terms: D000818:Animals; D001843:Bone Cements / Q000494:pharmacology*; D001858:Bone Nails; D016723:Bone Remodeling / Q000187:drug effects; D005269:Femur / Q000033:anatomy & histology / Q000098:blood supply / Q000502:physiology / Q000601:surgery*; D010521:Periosteum / Q000033:anatomy & histology / Q000187:drug effects / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar
chemical_list: D001843:Bone Cements