title: Serum S-100 has prognostic significance in malignant melanoma.
abstract: BACKGROUND
  Pretreatment serum values of S-100 and NSE were compared in patients with malignant melanoma.
  
  
  METHODS
  Pretreatment serum levels of patients with malignant melanoma were analysed for stage of disease and survival.
  
  
  RESULTS
  S-100 pretreatment serum values seem highly specific, but have low sensitivity.
  
  
  CONCLUSIONS
  Further evaluation is needed with an assay with improved sensitivity.
authors.affiliation: Department of Clinical Chemistry, The Netherlands Cancer Institute (Antoni van Leeuwenhoek Huis), Amsterdam, The Netherlands.
authors.forename: J M
authors.initials: JM
authors.lastname: Bonfrer
authors.forename: C M
authors.initials: CM
authors.lastname: Korse
authors.forename: S P
authors.initials: SP
authors.lastname: Israels
mesh_terms: D006801:Humans; D008545:Melanoma / Q000097:blood*; D010751:Phosphopyruvate Hydratase / Q000097:blood; D011379:Prognosis; D009418:S100 Proteins / Q000097:blood*; D012680:Sensitivity and Specificity
chemical_list: D009418:S100 Proteins; D010751:Phosphopyruvate Hydratase