Generating, partitioning, targeting and functioning of superoxide in mitochondria.
Recently, we proposed a hypothetical model of coexistence of "Reactive oxygen cycle" with Q cycle and H+ cycle in mitochondrial respiratory chain to combine both processes of univalent electron leak for production of superoxide and of proton leak across inner mitochondrial membrane. This review presents a more detailed description of this model and summaries the supporting experimental evidence obtained.
Liu
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SS
State Key Laboratory of Biomembrane and Membrane Biotechnology, Chinese Academy of Sciences, Beijing, China.
D000818:Animals; D002462:Cell Membrane / Q000378:metabolism; D019069:Cell Respiration; D006801:Humans; D008564:Membrane Potentials; D008928:Mitochondria / Q000378:metabolism*; D008954:Models, Biological; D011522:Protons; D017382:Reactive Oxygen Species; D013481:Superoxides / Q000378:metabolism*
D011522:Protons; D017382:Reactive Oxygen Species; D013481:Superoxides