title: Molecular markers for throat and skin isolates of group A streptococci.
abstract: In summary, the emm chromosomal patterns distinguish between the two principal tissue site reservoirs of group A streptococci--the nasopharyngeal mucosa and impetigo lesion. Strains derived from normally sterile tissue sites are probably transmitted to new hosts by respiratory droplets, at least in the Connecticut population. The speA gene provides an example of how genetic exchange between different strains of group A streptococci may be limited to a single tissue site or to a subset of emm chromosomal patterns.
authors.affiliation: Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut, USA.
authors.forename: D E
authors.initials: DE
authors.lastname: Bessen
authors.forename: T R
authors.initials: TR
authors.lastname: Fiorentino
authors.forename: S K
authors.initials: SK
authors.lastname: Hollingshead
mesh_terms: D000942:Antigens, Bacterial; D001425:Bacterial Outer Membrane Proteins; D001426:Bacterial Proteins / Q000235:genetics; D002352:Carrier Proteins; D002353:Carrier State / Q000382:microbiology; D002876:Chromosomes, Bacterial / Q000235:genetics; D005098:Exotoxins / Q000235:genetics; D015321:Gene Rearrangement; D018014:Gene Transfer Techniques; D005798:Genes, Bacterial; D005819:Genetic Markers; D006801:Humans; D007169:Impetigo / Q000382:microbiology; D008565:Membrane Proteins; D008957:Models, Genetic; D009305:Nasopharynx / Q000382:microbiology*; D009928:Organ Specificity; D010612:Pharyngitis / Q000382:microbiology; D012213:Rheumatic Fever / Q000382:microbiology; D012703:Serotyping; D012867:Skin / Q000382:microbiology*; D013290:Streptococcal Infections / Q000382:microbiology; D013297:Streptococcus pyogenes / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification*
chemical_list: D000942:Antigens, Bacterial; D001425:Bacterial Outer Membrane Proteins; D001426:Bacterial Proteins; D002352:Carrier Proteins; D005098:Exotoxins; D005819:Genetic Markers; D008565:Membrane Proteins; C117980:SpeA protein, Streptococcus pyogenes; C027951:erythrogenic toxin; C014689:streptococcal M protein