[Morphological aspects of the effect of magnesium orotate therapy on changes in the vascular walls induced by cholesterol-rich diet].
Heart and blood vessel disease are one of the leading causes of death, so their prevention and therapy are very important. In the present study the effects of magnesium chloride, magnesium orotate and orotic acid were tested. New Zealand rabbits were fed with enriched (2%) cholesterol diet during 112 days: starting with day 56 all rabbits were treated with MgCl2, Mg-orotate or orotic acid (orally). Aortas, coronaries, renal and femoral arteries were removed and evaluated by morphological and morphometric methods. Atherosclerotic alterations in each vessel could be influenced moderately by Mg-chloride, quite well by orotic acid and excellently by Mg-orotate. From these results one can conclude that orotic acid and Mg-orotate have a beneficial effect in the prevention and therapy of heart and vessels diseases.
Jellinek
H
H
Országos Pathologiai Intézet Budapest.
Takács
E
E
D000818:Animals; D001161:Arteriosclerosis / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology / Q000517:prevention & control; D002791:Cholesterol, Dietary / Q000008:administration & dosage*; D004036:Diet, Atherogenic; D004195:Disease Models, Animal; D006937:Hypercholesterolemia / Q000517:prevention & control; D015636:Magnesium Chloride; D009963:Orotic Acid / Q000008:administration & dosage*; D011817:Rabbits; D011859:Radiography
D002791:Cholesterol, Dietary; D015636:Magnesium Chloride; D009963:Orotic Acid