Intraarticular dexamethasone in advanced chronic synovitis in hemophilia.
From 1988 to 1966, 34 patients with advanced chronic hemophilic synovitis (25 Grade III and nine Grade IV) were treated with intraarticular injections of long acting dexamethasone (sodium phosphate of dexamethasone plus acetate of dexamethasone) in cycles of three injections with 3-week intervals between each injection with 6-month rest intervals between cycles for as many as three cycles, depending on the evolution of each case. All patients had chronic severe synovitis, axial deformity, muscular atrophy, and diminution of range of movement. There were 31 knees, two ankles, and two shoulders. Subjective and objective evaluations were done grouping the results in good, fair, and poor according to grade of patient satisfaction, presence of synovitis and pain, range of movement, and limitation of activities of daily living. In the subjective results there were 19 good results, 12 fair results, and four poor results, and in the objective evaluation there were 22 good results, nine fair results, and four poor results at an average followup of 1.5 years. The use of intraarticular dexamethasone as an alternative in the short to medium term for treatment of advanced chronic hemophilic synovitis with pain and limitation of function before doing an invasive surgical treatment is proposed.
Fernández-Palazzi
F
F
Orthopaedic Unit, National Hemophilia Treatment Center, Hospital San Juán de Dios, Caracas, Venezuela.
Caviglia
H A
HA
Salazar
J R
JR
López
J
J
Aoun
R
R
D000203:Activities of Daily Living; D000293:Adolescent; D000328:Adult; D000843:Ankle Joint / Q000187:drug effects; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D018771:Arthralgia / Q000188:drug therapy; D002908:Chronic Disease; D003907:Dexamethasone / Q000008:administration & dosage / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D005500:Follow-Up Studies; D005938:Glucocorticoids / Q000008:administration & dosage / Q000627:therapeutic use*; D006395:Hemarthrosis / Q000145:classification / Q000188:drug therapy / Q000209:etiology; D006467:Hemophilia A / Q000150:complications*; D002836:Hemophilia B / Q000150:complications; D006801:Humans; D007270:Injections, Intra-Articular; D016916:Joint Deformities, Acquired / Q000209:etiology; D007719:Knee Joint / Q000187:drug effects; D009133:Muscular Atrophy / Q000209:etiology; D017060:Patient Satisfaction; D016059:Range of Motion, Articular; D012785:Shoulder Joint / Q000187:drug effects; D013585:Synovitis / Q000145:classification / Q000188:drug therapy* / Q000209:etiology / Q000601:surgery; D016896:Treatment Outcome
D000893:Anti-Inflammatory Agents; D005938:Glucocorticoids; D003907:Dexamethasone