[The role of free radicals in the etiopathogenesis of systemic sclerosis].
This article reviews the current concept in the ethiology and pathogenesis of systemic sclerosis. It is suggested that free radicals play a crucial role in pathomechanisms of scleroderma. In addition, the influence of some environmental agents (silica, bleomycin, alcohol, toxic oil) on free radical production and subsequent induction of scleroderma or scleroderma-like syndrome is also described.
Komosińska
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Katedra i Zakład Chemii Klinicznej i Diagnostyki Laboratoryjnej Slaskiej Akademii Medycznej w Sosnowcu.
Olczyk
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Winsz
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D000975:Antioxidants / Q000378:metabolism; D001761:Bleomycin / Q000009:adverse effects; D004781:Environmental Exposure / Q000009:adverse effects; D000431:Ethanol / Q000009:adverse effects; D005347:Fibroblasts / Q000502:physiology; D005609:Free Radicals / Q000009:adverse effects* / Q000378:metabolism; D006801:Humans; D017382:Reactive Oxygen Species / Q000502:physiology; D012595:Scleroderma, Systemic / Q000209:etiology*; D012822:Silicon Dioxide / Q000009:adverse effects; D014752:Vinyl Chloride / Q000009:adverse effects
D000975:Antioxidants; D005609:Free Radicals; D017382:Reactive Oxygen Species; D001761:Bleomycin; D000431:Ethanol; D012822:Silicon Dioxide; D014752:Vinyl Chloride