[Lymph node eosinophilic granuloma. Apropos of 2 cases of Langerhans-cell histiocytosis with isolated lymph node involvement].
The authors report two cases of isolated lymph node involvement by Langerhans' cell histiocytosis which affected two young children. The histologic aspect reveals that lymph nodes have been modified by a proliferation of large histiocyte-like cells, associated with eosinophils. An immunohistochemical study on paraffin sections and for one case on frozen sections, reveals the usual phenotype of Langerhans' cells: these cells stain positively with S 100 protein and CD1 and are negative for both lysozyme and al antichymotrypsine. After a period of two years for one child and four years for the other, these children are in total remission, one spontaneously, the other after chemotherapy.
Robert
M
M
Laboratoire d'Anatomie Pathologique, Hôpital Gaston Doumergue, Nîmes.
Marty-Double
C
C
D002675:Child, Preschool; D003937:Diagnosis, Differential; D004803:Eosinophilic Granuloma / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy; D006646:Histiocytosis, Langerhans-Cell / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy; D006801:Humans; D007223:Infant; D008198:Lymph Nodes / Q000473:pathology*; D008297:Male; D009333:Neck