title: Breast cancer: the high-risk mutations.
abstract: Mutations in the two known BRCA genes account for only 5% to 10% of breast cancer. The genes may play a role in genomic stability; their role in sporadic cancer remains unknown. Hence, genetic testing has created clinical dilemmas. Some pertain to women whose family history suggests inherited risk. Others, including the false reassurance that may be conferred by a negative finding, apply throughout the general population.
authors.affiliation: National Institutes of Health, Laboratory of Gene Transfer, Bethesda, Md., USA.
authors.forename: L C
authors.initials: LC
authors.lastname: Brody
authors.forename: B B
authors.initials: BB
authors.lastname: Biesecker
mesh_terms: D019313:BRCA1 Protein / Q000235:genetics; D024682:BRCA2 Protein; D001943:Breast Neoplasms / Q000208:ethnology / Q000235:genetics*; D005260:Female; D019398:Genes, BRCA1 / Q000235:genetics; D005819:Genetic Markers / Q000235:genetics; D006801:Humans; D007585:Jews / Q000235:genetics; D009154:Mutation / Q000235:genetics*; D009363:Neoplasm Proteins / Q000235:genetics; D010375:Pedigree; D012307:Risk Factors; D014157:Transcription Factors / Q000235:genetics
chemical_list: D019313:BRCA1 Protein; D024682:BRCA2 Protein; D005819:Genetic Markers; D009363:Neoplasm Proteins; D014157:Transcription Factors