title: Calciuria in children with juvenile chronic arthritis.
abstract: Demineralization of bone is a frequent finding in children with juvenile chronic arthritis (JCA). Recently there have been reports about hypercalciuria accompanying JCA. This is believed to be associated with increased bone resorption due to cytokines and immobility of the patients and steroid treatment. In 12 patients with confirmed diagnosis of JCA basic biochemical indices of bone metabolism, were performed (S-Ca, P, ALP, U-Ca/U-creatinine, U-P). Bone mineral density (BMD) was measured using DPXA method and results obtained were compared to the Lunar BMD DPXA standards. In spite of decreased BMD, no significant hypercalciuria was found and other mentioned biochemical indices of bone and mineral metabolism were normal as well.
authors.affiliation: Department of Pediatrics, First Medical Faculty, Charles University, Prague, Czech Republic.
authors.forename: D
authors.initials: D
authors.lastname: Nĕmcová
authors.forename: S
authors.initials: S
authors.lastname: Kutílek
authors.forename: M
authors.initials: M
authors.lastname: Bayer
authors.forename: J J
authors.initials: JJ
authors.lastname: Stĕpán
authors.forename: J
authors.initials: J
authors.lastname: Hoza
mesh_terms: D000293:Adolescent; D000328:Adult; D001171:Arthritis, Juvenile / Q000150:complications / Q000378:metabolism / Q000652:urine*; D015519:Bone Density; D001862:Bone Resorption / Q000209:etiology / Q000652:urine; D002118:Calcium / Q000652:urine*; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D011241:Prednisone / Q000009:adverse effects
chemical_list: D002118:Calcium; D011241:Prednisone