Reduction of myocardial ischemia-reperfusion injury by isovolumic hemodilution.
In order to study the effects of isovolumic hemodilution and its combination with Danshen solution on acute ischemic reperfused canine myocardium, 24 adult hybrid dogs were used and divided into four groups. Group I was the control group, groups II-IV were treated with Dextron 40, Danshen solution and a combination of the two, respectively. The results showed that either Dextron 40 or Danshen solution alone had a significant increase of +/- dp/dt-max when compared with group I (p < 0.05). Although no significant difference existed between group II and III, the former showed more rapid action. The combination of the two therapies improved +/- dp/dt-max and LVSP, and significantly reduced the necrotic sizes and the MDA contents in the ischemic myocardia compared with not only group I, but also group II or group III (all p < 0.05). The results suggest that isovolumic hemodilution or Danshen may protect the ischemic reperfused myocardium and the former may come into action more rapidly, and that the combination of the two may show a better synergism than each one of the two by itself.
Wang
B S
BS
Department of Pathophysiology, First College for Clinical Medicine, Henan Medical University, Zhengzhou, China.
Wang
L J
LJ
Zhang
Y B
YB
Lu
J S
JS
Tang
N
N
Huang
Y T
YT
Yan
W H
WH
Song
W
W
D000818:Animals; D003911:Dextrans / Q000627:therapeutic use*; D004285:Dogs; D005260:Female; D006438:Hemodilution / Q000379:methods*; D018056:Hemorheology; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D015428:Myocardial Reperfusion Injury / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D009336:Necrosis; D012996:Solutions
D003911:Dextrans; D012996:Solutions; D008315:Malondialdehyde