[Reversible neuropsychiatric side effects of lithium with normal serum levels. A case report].
Lithium therapy in patients with manic depressive disorder occasionally causes neuropsychiatric side effects even at therapeutic serum levels. Those lithium-induced symptoms can be polymorphous and may be hard to differentiate from other disorders and from other drugs' side effects. We report the case of a 56-year-old woman with manic-depressive illness, who developed neuropsychiatric side effects from lithium prophylaxis at therapeutic serum levels. The symptoms included disorientation, aphasia, ideatoric apraxia, parkinsonism, restlessness and severe sleep disorder. In contrast to previous reports, the casual role lithium was underscored by symptom increase after lithium re-exposure at therapeutic serum levels. The patient recovered completely after cessation of the lithium prophylaxis.
Fallgatter
A J
AJ
Psychiatrische Klinik und Poliklinik, Universität Würzburg.
Strik
W K
WK
D018692:Antimanic Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000493:pharmacokinetics; D001037:Aphasia / Q000139:chemically induced / Q000175:diagnosis / Q000523:psychology; D001072:Apraxias / Q000139:chemically induced / Q000175:diagnosis / Q000523:psychology; D001714:Bipolar Disorder / Q000097:blood / Q000188:drug therapy* / Q000523:psychology; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D016651:Lithium Carbonate / Q000008:administration & dosage / Q000009:adverse effects* / Q000493:pharmacokinetics; D008875:Middle Aged; D009460:Neurologic Examination / Q000187:drug effects*; D009483:Neuropsychological Tests; D010302:Parkinson Disease, Secondary / Q000139:chemically induced* / Q000175:diagnosis / Q000523:psychology; D012008:Recurrence; D019966:Substance-Related Disorders / Q000175:diagnosis* / Q000523:psychology
D018692:Antimanic Agents; D016651:Lithium Carbonate