Unexpected correlation in the sensitivity of 19 herpes simplex virus strains to types I and II interferons.
We compared the sensitivity of 19 herpes simplex virus (HSV) strains to type I (IFN-alpha and IFN-beta) and type II (IFN-gamma) human interferons in cultures of human retinal epithelial (K-1034) and lung (HEL) cells. Their sensitivities proved to be well correlated, even though type I and type II IFN have been reported to have different antiviral actions. The correlation was not because IFN-gamma stimulated the formation of IFN-beta, for an antibody that neutralized IFN-beta did not reduce its inhibitory effects. Our results show that each HSV strain has a characteristic and similar sensitivity to type I and type II IFN and suggest some common pathway in the mechanism of their antiviral actions.
Arao
Y
Y
Department of Pathology, National Institute of Infectious Diseases, Tokyo, Japan.
Ando
Y
Y
Narita
M
M
Kurata
T
T
D002478:Cells, Cultured; D006801:Humans; D007370:Interferon Type I / Q000494:pharmacology*; D007371:Interferon-gamma / Q000494:pharmacology*; D008168:Lung / Q000166:cytology / Q000187:drug effects*; D010857:Pigment Epithelium of Eye / Q000166:cytology / Q000187:drug effects*; D018139:Simplexvirus / Q000187:drug effects*
D007370:Interferon Type I; D007371:Interferon-gamma