The importance of cellular environment to function of the CD44 matrix receptor.
Much has been learned recently by experimental manipulation of the structure of CD44 and assessment of the resulting functions. However, even greater structural variation is naturally introduced by CD44-bearing cells. A structural model is now available for the portion of CD44 that recognizes hyaluronan, but it is clear that all domains of the molecule influence CD44 functions.
Kincade
P W
PW
Oklahoma Medical Research Foundation, Oklahoma City 73104, USA. paul-kincade@omrf.ouhsc.edu
Zheng
Z
Z
Katoh
S
S
Hanson
L
L
D000818:Animals; D005109:Extracellular Matrix; D006031:Glycosylation; D018960:Hyaluronan Receptors / Q000737:chemistry*; D006820:Hyaluronic Acid / Q000378:metabolism
D018960:Hyaluronan Receptors; D006820:Hyaluronic Acid