title: Crossover trials with a cumulative response.
abstract: We consider the use of a crossover design when the response is long-lasting and cumulative. Examples include the treatment of chronic diseases such as cerebral palsy, and educational and psychological intervention studies. Cumulative response models are developed for the two-treatment, two-period design. Various estimators for the treatment and carryover effects are compared, and ANOVA tables are derived. The crossover design including pretreatment observations is found to be more cost-efficient than the one-period randomised design. Without pretreatment data, it may be more or less efficient, depending on the reliability of the data, and the costs of subject recruitment, treatment, and observation.
authors.affiliation: Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada.
authors.forename: S D
authors.initials: SD
authors.lastname: Walter
mesh_terms: D000704:Analysis of Variance; D018592:Cross-Over Studies; D006801:Humans; D015233:Models, Statistical; D016032:Randomized Controlled Trials as Topic / Q000379:methods*; D012107:Research Design; D013997:Time Factors