A case of acute deterioration in asthma symptoms induced by isoniazid prophylaxis.
The present case report describes a 10-year-old boy with clinical history of steroid-dependent asthma who developed severe exacerbation of his respiratory symptoms upon isoniazid administration. Subsequent control of his asthma symptoms was re-established and maintained only after isoniazid withdrawal. This case is the first to emphasize the dangers of isoniazid administration in patients who have asthma.
Polosa
R
R
Istituto Malattie Apparato Respiratorio, Università di Catania, Italy.
Colombrita
R
R
Prosperini
G
G
Cacciola
R
R
D000208:Acute Disease; D000995:Antitubercular Agents / Q000009:adverse effects*; D001249:Asthma / Q000139:chemically induced* / Q000503:physiopathology; D002648:Child; D006801:Humans; D007538:Isoniazid / Q000009:adverse effects*; D008297:Male; D010366:Peak Expiratory Flow Rate / Q000187:drug effects; D014376:Tuberculosis / Q000517:prevention & control*
D000995:Antitubercular Agents; D007538:Isoniazid