title: Clinical and clinicopathologic effects of large doses of raw linseed oil as compared to mineral oil in healthy horses.
abstract: The clinical and clinicopathologic effects of raw linseed oil and mineral oil were compared. In a crossover experimental design trial, 6 horses were given either raw linseed oil (2.5 mL/kg body weight) or mineral oil (10 mL/kg body weight), twice, 12 hours apart. Two weeks later, the horses received the opposite treatment. All horses given mineral oil or linseed oil developed nonformed feces by 24 hours of the first administration of oil. Horses treated with mineral oil had formed feces at 48 hours; horses treated with linseed oil developed normally formed feces at 96 to 108 hours. All horses treated with linseed oil had signs of depression and anorexia, and 3 had signs of mild colic. These signs were not observed in horses treated with mineral oil. Concentrations of serum glucose and bilirubin were significantly higher in horses treated with linseed oil when compared with horses treated with mineral oil.
authors.affiliation: Department of Large Animal Surgery and Medicine, Auburn University College of Veterinary Medicine, Auburn University, AL 36849-5522, USA.
authors.forename: J
authors.initials: J
authors.lastname: Schumacher
authors.forename: F J
authors.initials: FJ
authors.lastname: DeGraves
authors.forename: J S
authors.initials: JS
authors.lastname: Spano
mesh_terms: D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001663:Bilirubin / Q000097:blood; D001772:Blood Cell Count / Q000662:veterinary; D001786:Blood Glucose / Q000032:analysis; D001798:Blood Proteins / Q000032:analysis; D001806:Blood Urea Nitrogen; D002400:Cathartics / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D003404:Creatinine / Q000097:blood; D018592:Cross-Over Studies; D004305:Dose-Response Relationship, Drug; D004573:Electrolytes / Q000097:blood; D005260:Female; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology; D006736:Horses / Q000097:blood* / Q000502:physiology; D007441:Intubation, Gastrointestinal; D008043:Linseed Oil / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D008899:Mineral Oil / Q000008:administration & dosage / Q000494:pharmacology*; D010758:Phosphorus / Q000097:blood; D013997:Time Factors
chemical_list: D001786:Blood Glucose; D001798:Blood Proteins; D002400:Cathartics; D004573:Electrolytes; D010758:Phosphorus; D008043:Linseed Oil; D008899:Mineral Oil; D003404:Creatinine; D001219:Aspartate Aminotransferases; D001663:Bilirubin