Cell adhesion: a new target for therapy.
Intercellular adhesive events are involved in a wide range of biological processes, including pattern formation and morphogenesis during development, immune responses, leukocyte recirculation, wound repair, tumour growth and metastasis. In the multicellular state, signals from cell adhesion molecules, along with those from growth factor and cytokine receptors, provide a range of information to the cell that is integrated to yield a final message, perhaps to maintain the cell cycle (if it is a stem cell) or follow a path towards terminal differentiation. Aberrant cell adhesion plays a key role in many developmental defects, acute and chronic inflammatory disease and cancer.
Buckley
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Dept of Rheumatology, University of Birmingham, Edgbaston, UK.
Simmons
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D000818:Animals; D015820:Cadherins / Q000378:metabolism; D002448:Cell Adhesion / Q000235:genetics / Q000502:physiology*; D015815:Cell Adhesion Molecules / Q000378:metabolism*; D002450:Cell Communication; D002465:Cell Movement; D029721:Drosophila Proteins; D004727:Endothelium / Q000502:physiology; D066246:ErbB Receptors / Q000378:metabolism; D006801:Humans; D007962:Leukocytes / Q000502:physiology; D011518:Proto-Oncogene Proteins / Q000378:metabolism; D020794:Receptor Protein-Tyrosine Kinases / Q000378:metabolism; D015398:Signal Transduction; D051155:Wnt1 Protein
D015820:Cadherins; D015815:Cell Adhesion Molecules; D029721:Drosophila Proteins; D011518:Proto-Oncogene Proteins; D051155:Wnt1 Protein; C074622:wg protein, Drosophila; D066246:ErbB Receptors; D020794:Receptor Protein-Tyrosine Kinases