title: Intrathecal sufentanil for labor analgesia does not cause a sympathectomy.
abstract: BACKGROUND
  Intrathecal sufentanil (ITS) is frequently used to provide analgesia during labor. Decreases in blood pressure and sensory changes in this circumstance suggest that ITS may have a local anesthetic effect and thus cause a sympathectomy. To determine whether ITS given to laboring women causes a sympathectomy, the authors evaluated central and lower extremity temperature changes after ITS administration. These findings were compared with those in a control group of women having spinal anesthesia with bupivacaine for elective cesarean section in whom an extensive sympathectomy was expected.
  
  
  METHODS
  Twenty parturients classified as American Society of Anesthesiologists' physical status 1 or 2 had temperatures measured centrally, at the calf, and at the great toe at frequent intervals after receiving 10 microg ITS for labor analgesia (sufentanil group, n = 10), or hyperbaric bupivacaine 12 mg in their spinal anesthetic for cesarean section (bupivacaine group, n = 10). Calf-to-toe temperature indices (C-T) were calculated by subtracting toe temperature from calf temperature. A decrease in this index means that the toe had warmed compared with the calf and is an indication of vasodilation and a sympathectomy.
  
  
  RESULTS
  There was no significant change in the C-T indices or central temperature in the sufentanil group, but the C-T indices and central temperature decreased significantly in the bupivacaine group.
  
  
  CONCLUSIONS
  The decreases in the C-T index and central temperature in the bupivacaine group indicate the presence of a sympathectomy. The lack of change in the C-T indices and central temperature in the sufentanil group indicates that no significant vasodilation occurred. Therefore, the decrease in blood pressure seen after ITS administration for labor analgesia is unlikely to be the result of a sympathectomy.
authors.affiliation: Department of Anesthesia, Stanford University School of Medicine, California 94305, USA. edriley@Leland.Stanford.edu
authors.forename: E T
authors.initials: ET
authors.lastname: Riley
authors.forename: D
authors.initials: D
authors.lastname: Walker
authors.forename: C L
authors.initials: CL
authors.lastname: Hamilton
authors.forename: S E
authors.initials: SE
authors.lastname: Cohen
mesh_terms: D000328:Adult; D016362:Analgesia, Obstetrical; D000701:Analgesics, Opioid / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D001831:Body Temperature / Q000187:drug effects; D005260:Female; D006801:Humans; D007278:Injections, Spinal; D011247:Pregnancy; D017409:Sufentanil / Q000008:administration & dosage / Q000494:pharmacology*; D013564:Sympathetic Nervous System / Q000187:drug effects*
chemical_list: D000701:Analgesics, Opioid; D017409:Sufentanil