title: ARVD4, a new locus for arrhythmogenic right ventricular cardiomyopathy, maps to chromosome 2 long arm.
abstract: Autosomal dominant arrhythmogenic right ventricular dysplasia (ARVD; MIM 107970) is a genetically heterogeneous cardiomyopathy, which often causes sudden death in juveniles and athletes. Two disease loci were previously mapped respectively to 14q23-q24 (ARVD1) and to 1q42-q43 (ARVD2). A third possible locus was assigned to 14q12-q22. We report here on a linkage study performed on three independent families with recurrence of ARVD characterized by localized involvement of the left ventricle. In these families the disease appears to be transmitted with three polymorphic DNA markers of the chromosome 2 long arm, showing a maximum lod score of 3.46 at theta = 0 for the marker D2S152. The multipoint linkage analysis suggests that the novel ARVD locus, provisionally named ARVD4, maps to 2q32. 1-q32.3, within the chromosomal region including markers D2S152, D2S103, and D2S389.
authors.affiliation: Department of Biology, University of Padua, Padua, I-35121, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Rampazzo
authors.forename: A
authors.initials: A
authors.lastname: Nava
authors.forename: M
authors.initials: M
authors.lastname: Miorin
authors.forename: P
authors.initials: P
authors.lastname: Fonderico
authors.forename: B
authors.initials: B
authors.lastname: Pope
authors.forename: N
authors.initials: N
authors.lastname: Tiso
authors.forename: B
authors.initials: B
authors.lastname: Livolsi
authors.forename: R
authors.initials: R
authors.lastname: Zimbello
authors.forename: G
authors.initials: G
authors.lastname: Thiene
authors.forename: G A
authors.initials: GA
authors.lastname: Danieli
mesh_terms: D019571:Arrhythmogenic Right Ventricular Dysplasia / Q000235:genetics*; D002874:Chromosome Mapping; D002889:Chromosomes, Human, Pair 2 / Q000235:genetics*; D005260:Female; D005799:Genes, Dominant; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D008126:Lod Score; D008297:Male; D010375:Pedigree
chemical_list: D005819:Genetic Markers