Acute myeloid leukemia following psoralen with ultraviolet A therapy: a fluorescence in situ hybridization study.
A woman with mycosis fungoides treated by psoralen with ultraviolet A (PUVA) and electron beam therapy developed acute myeloid leukemia (AML) three years later. Karyotypic analysis of the leukemia cells revealed monosomy 7. Fluorescence in situ hybridization showed that the monosomy 7 clone had accounted for about a third of the marrow cells after PUVA treatment, but replaced the entire marrow at leukemic transformation. These findings were consistent with a secondary AML evolving from an underlying myelodysplasia, supporting that PUVA therapy might have a mutagenic effect on hematopoietic cells. This might be related to its effect on circulating hematopoietic stem cells.
Kwong
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University Department of Medicine, Queen Mary Hospital, Hong Kong, People's Republic of China.
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Chan
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D002897:Chromosomes, Human, Pair 7; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D015470:Leukemia, Myeloid, Acute / Q000139:chemically induced* / Q000235:genetics*; D008875:Middle Aged; D009006:Monosomy; D009182:Mycosis Fungoides / Q000188:drug therapy / Q000532:radiotherapy; D011701:PUVA Therapy / Q000009:adverse effects*