title: Technetium-99m HMPAO labeled leukocytes as the primary diagnostic tool in a case of brain abscess.
abstract: The authors present a case in which Tc-99m HMPAO labeled autologous leukocytes were used to demonstrate a brain abscess in a patient undergoing evaluation for fever of unknown origin. The abscess was demonstrated on both 1-hour and 24-hour images. The positive 1-hour image led to CT and MRI studies, which are included for correlation. In addition to its previously identified role as a secondary diagnostic test in the differentiation of tumor and abscess, the authors propose that Tc-99m HMPAO is useful as a primary diagnostic tool in the identification of brain abscess. Furthermore, the authors suggest that Tc-99m HMPAO is preferable to In-111 labeled leukocytes because of its better resolution and earlier imaging characteristics.
authors.affiliation: Department of Radiology, Mercy Hospital of Pittsburgh, PA 15219, USA.
authors.forename: P R
authors.initials: PR
authors.lastname: Saba
authors.forename: K
authors.initials: K
authors.lastname: McDonald
authors.forename: J
authors.initials: J
authors.lastname: Hunn
authors.forename: K
authors.initials: K
authors.lastname: Dastur
authors.forename: V
authors.initials: V
authors.lastname: Chablani
mesh_terms: D000368:Aged; D001922:Brain Abscess / Q000150:complications / Q000175:diagnosis / Q000000981:diagnostic imaging*; D005335:Fever of Unknown Origin / Q000209:etiology; D005625:Frontal Lobe / Q000000981:diagnostic imaging / Q000382:microbiology; D006801:Humans; D007089:Image Enhancement; D007205:Indium Radioisotopes; D007962:Leukocytes; D008279:Magnetic Resonance Imaging; D008297:Male; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D013290:Streptococcal Infections / Q000150:complications / Q000175:diagnosis / Q000000981:diagnostic imaging*; D013291:Streptococcus / Q000145:classification; D019690:Technetium Tc 99m Exametazime; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D014182:Transplantation, Autologous; D014915:Whole-Body Counting
chemical_list: D007205:Indium Radioisotopes; D019275:Radiopharmaceuticals; D019690:Technetium Tc 99m Exametazime