title: Role of left ventricular hypertrophy in diastolic dysfunction in aged hypertensive patients.
abstract: OBJECTIVE
  To evaluate the influence of left ventricular hypertrophy (LVH) on the diastolic dysfunction in older hypertensive patients.
  
  
  METHODS
  In total 665 patients (58% men, 61% White, aged 55-80 years) with mild-to-moderate essential hypertension underwent Doppler echocardiography. Data included left ventricular dimensions, left ventricular mass index, body mass index, E- and A-wave mitral flow velocities, E:A ratio, deceleration time > 150 ms), impaired relaxation (E:A ratio < 1.0, prolonged deceleration time according to age), and restrictive physiology (E:A ratio > 2.1, deceleration time < 150 ms)]. Data were distributed according to age (50-59, 60-69, and 70-80 years).
  
  
  RESULTS
  The overall prevalence of sex-adjusted LVH in this study was 65%. When we compared hypertensive patients with and without LVH, the E- and A-wave velocities, E:A ratio, and deceleration time were similar. Moreover, the prevalences of normal, impaired relaxation, and restrictive physiology patterns among patients with and without LVH did not differ significantly (20, 79.5, and 0.5 versus 24, 75.5, and 0.5%). When the mitral flow patterns were adjusted according to age, the impaired relaxation pattern increased further with age (to 73% during the fifth decade, 83% during the sixth decade, and 88% during the seventh decade).
  
  
  CONCLUSIONS
  LVH is not an independent factor associated with abnormal flow patterns in hypertensive patients aged over 50 years with normal systolic contractility. The impaired relaxation is the predominant pattern of diastolic dysfunction in older hypertensive patients and increases further with aging.
authors.affiliation: Department of Medicine/Cardiology, University of Texas Health Science Center at San Antonio, USA.
authors.forename: M
authors.initials: M
authors.lastname: Zabalgoitia
authors.forename: S N
authors.initials: SN
authors.lastname: Ur Rahman
authors.forename: W E
authors.initials: WE
authors.lastname: Haley
authors.forename: D A
authors.initials: DA
authors.lastname: Abochamh
authors.forename: L
authors.initials: L
authors.lastname: Oneschuk
authors.forename: J
authors.initials: J
authors.lastname: Amerena
authors.forename: S
authors.initials: S
authors.lastname: Yarows
authors.forename: L
authors.initials: L
authors.lastname: Krause
authors.forename: C
authors.initials: C
authors.lastname: Yunis
authors.forename: C
authors.initials: C
authors.lastname: Lucas
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001783:Blood Flow Velocity; D001794:Blood Pressure; D003971:Diastole / Q000502:physiology*; D015150:Echocardiography, Doppler; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000503:physiopathology*; D017379:Hypertrophy, Left Ventricular / Q000453:epidemiology / Q000209:etiology / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D008943:Mitral Valve / Q000000981:diagnostic imaging; D015995:Prevalence; D011446:Prospective Studies