Basic fibroblast growth factor and platelet-derived growth factor prevent the death of spinal motor neurons after sciatic nerve transection in the neonatal rats.
In vivo, motor neurons are destined to die after axotomy. Several neuronal growth factors, such as ciliary neurotrophic factor, brain-derived neurotrophic factor, and leukemia inhibitory factor rescue neuronal death of axotomized motor neurons. Here, we report that systemically administered basic fibroblast growth factor and platelet-derived growth factor prevented spinal motor neuron death in neonatal rats following sciatic nerve resection. These data indicate that basic fibroblast growth factor and platelet derived growth factor play a role for motor neuron survival in vivo.
Iwasaki
Y
Y
Fourth Department of Internal Medicine, Toho University, Ohashi Hospital, Tokyo, Japan.
Shiojima
T
T
Tagaya
N
N
Kobayashi
T
T
Kinoshita
M
M
D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D019771:Axotomy; D016923:Cell Death / Q000187:drug effects; D005260:Female; D016222:Fibroblast Growth Factor 2 / Q000494:pharmacology*; D008297:Male; D009046:Motor Neurons / Q000187:drug effects* / Q000502:physiology; D010982:Platelet-Derived Growth Factor / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012584:Sciatic Nerve / Q000502:physiology*; D013116:Spinal Cord / Q000166:cytology / Q000187:drug effects*
D010982:Platelet-Derived Growth Factor; D016222:Fibroblast Growth Factor 2