Matrix and adhesion molecules in kidney pathology: recent observations.
The purpose of this article is to review a set of recently obtained data concerning matrix and matrix adhesion molecules in renal disease. Our goal is not to cover the entire topic, but rather to focus on findings obtained with an experimental model for chronic lupus nephritis, evoked in mice by inducing graft-versus-host disease (GVHD). The overall aim of these studies was to investigate the role of adhesion molecules as targets for autoantibodies, in the recruitment of inflammatory cells, and in the accumulation of matrix in kidney disorders. In addition, we set out to discover how matrix proteins in renal diseases differ from normal matrix molecules both quantitatively, in their increased frequency, and qualitatively, in their intramolecular structure. The advances in understanding and methodology described in this review imply a substantial capability for greater insight into the pathogenesis of kidney disease; for making better use of renal biopsies, such as in applying competitive reverse-transcriptase-polymerase chain reaction (RT-PCR) in RNA analysis for matrix; and in developing more effective treatment strategies for patients with kidney disease.
Bruijn
J A
JA
Department of Pathology, University of Leiden, The Netherlands.
Koostra
C J
CJ
Sutmuller
M
M
van Vliet
A I
AI
Bergijk
E C
EC
de Heer
E
E
D000818:Animals; D001323:Autoantibodies / Q000276:immunology; D015815:Cell Adhesion Molecules / Q000737:chemistry / Q000276:immunology / Q000378:metabolism*; D004195:Disease Models, Animal; D005109:Extracellular Matrix / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D016326:Extracellular Matrix Proteins / Q000737:chemistry / Q000276:immunology / Q000378:metabolism*; D006086:Graft vs Host Disease / Q000276:immunology; D006801:Humans; D007678:Kidney Glomerulus / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D008181:Lupus Nephritis / Q000276:immunology / Q000378:metabolism* / Q000473:pathology*; D051379:Mice
D001323:Autoantibodies; D015815:Cell Adhesion Molecules; D016326:Extracellular Matrix Proteins