title: Penetration of erythrocyte membrane by peroxynitrite: participation of the anion exchange protein.
abstract: Participation of the anion exchange protein (Band 3 protein) of the erythrocyte membrane in the transport of peroxynitrite into erythrocytes was shown by partial inhibition of hemoglobin oxidation by extracellular peroxynitrite in cells treated with Band 3 inhibitors. These results demonstrate that permeation in the anionic form may be a minor pathway in the membrane transport of the peroxynitrite anion/peroxynitrous acid couple, especially in membranes reach in anion exchangers or channels.
authors.affiliation: Department of Molecular Biophysics, University of Lódź, Poland. sosmirek@krysia.uni.lodz.pl
authors.forename: M
authors.initials: M
authors.lastname: Soszyński
authors.forename: G
authors.initials: G
authors.lastname: Bartosz
mesh_terms: D017878:4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid / Q000494:pharmacology; D012856:4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid / Q000494:pharmacology; D000328:Adult; D001457:Anion Exchange Protein 1, Erythrocyte / Q000037:antagonists & inhibitors / Q000378:metabolism*; D000838:Anions; D001692:Biological Transport; D004910:Erythrocyte Membrane / Q000378:metabolism*; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D006863:Hydrogen-Ion Concentration; D009566:Nitrates / Q000378:metabolism*; D010084:Oxidation-Reduction
chemical_list: D001457:Anion Exchange Protein 1, Erythrocyte; D000838:Anions; D006454:Hemoglobins; D009566:Nitrates; C039642:peroxynitric acid; D012856:4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; D017878:4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid