Therapeutic effects of omoconazole nitrate on experimental tinea pedis, an intractable dermatophytosis, in guinea-pigs.
The therapeutic efficacy of omoconazole nitrate was investigated in an experimental tinea pedis model produced by topical inoculation with Trichophyton mentagrophytes in guinea-pigs, which is pathologically similar to naturally infected tinea pedis in humans. Treatment with omoconazole nitrate cream was started on week 2 postinfection and continued for 3 or 4 weeks. Once-a-day application of 1% omoconazole nitrate to the site of infection exhibited an excellent therapeutic efficacy, and was superior to 1% bifonazole cream in culture result. This result suggests that omoconazole nitrate has a potential usefulness for the treatment of tinea pedis in humans.
Itoyama
T
T
Teikyo University Institute of Medical Mycology, Tokyo, Japan.
Uchida
K
K
Yamaguchi
H
H
Fujita
S
S
D000818:Animals; D000935:Antifungal Agents / Q000627:therapeutic use*; D005260:Female; D006168:Guinea Pigs; D007093:Imidazoles / Q000627:therapeutic use*; D014008:Tinea Pedis / Q000188:drug therapy* / Q000382:microbiology
D000935:Antifungal Agents; D007093:Imidazoles; C050566:omoconazole; C036596:bifonazole