title: Carcinosarcoma of the uterus: a clinicopathological multicenter CTF study.
abstract: The purpose of this paper is to retrospectively analyze the clinical and pathological data of 118 cases of uterine carcinosarcoma. Prognostic factors and management were evaluated. chi 2 and log-rank tests were performed. Surgical stage at time of surgery was the most important prognostic factor (P < 0.0001); in stage I-II disease depth of myometrial invasion and lymphatic/vascular space involvement were significantly related to outcome, whereas other factors were not useful. In stage I-II patients postoperative radiation did not improve 5-year disease-free survival. Survival curves in patients with advanced disease treated with cisplatin-containing regimens or with doxorubicin (without cisplatin)-containing regimens were overlapping.
authors.affiliation: Department of Obstetrics and Gynecology, University of Brescia, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Sartori
authors.forename: L
authors.initials: L
authors.lastname: Bazzurini
authors.forename: A
authors.initials: A
authors.lastname: Gadducci
authors.forename: F
authors.initials: F
authors.lastname: Landoni
authors.forename: A
authors.initials: A
authors.lastname: Lissoni
authors.forename: T
authors.initials: T
authors.lastname: Maggino
authors.forename: P
authors.initials: P
authors.lastname: Zola
authors.forename: B
authors.initials: B
authors.lastname: La Face
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002296:Carcinosarcoma / Q000473:pathology* / Q000601:surgery / Q000628:therapy; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D011379:Prognosis; D018714:Radiotherapy, Adjuvant; D012189:Retrospective Studies; D014594:Uterine Neoplasms / Q000473:pathology* / Q000601:surgery / Q000628:therapy