The hippocampus--the key structure in processing of emotional input in the central nervous system.
Gray's conception hypothesizes that anxiolytics act indirectly to impair the behavioural inhibition system through GABA-ergic modulation of the ascending NA and 5-HT pathways to the hippocampus. The obtained results support this theory.
Jessa
M
M
Institute of Psychiatry and Neurology, Department of Pharmacology and Physiology of Nervous System, Warsaw, Poland.
Nazar
M
M
Stefański
R
R
Płaznik
A
A
D000818:Animals; D003220:Conflict, Psychological; D004644:Emotions / Q000187:drug effects / Q000502:physiology*; D018755:GABA Agonists / Q000494:pharmacology; D018756:GABA Antagonists / Q000494:pharmacology; D006624:Hippocampus / Q000187:drug effects / Q000502:physiology*; D008845:Microinjections; D051381:Rats; D018079:Receptors, GABA / Q000187:drug effects / Q000502:physiology; D016194:Receptors, N-Methyl-D-Aspartate / Q000819:agonists / Q000037:antagonists & inhibitors; D011985:Receptors, Serotonin / Q000187:drug effects / Q000502:physiology; D012702:Serotonin Antagonists / Q000494:pharmacology; D017366:Serotonin Receptor Agonists / Q000494:pharmacology
D018755:GABA Agonists; D018756:GABA Antagonists; D018079:Receptors, GABA; D016194:Receptors, N-Methyl-D-Aspartate; D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D017366:Serotonin Receptor Agonists