Hodgkin's disease of the esophagus.
A 61-year-old man with acquired immunodeficiency syndrome (AIDS) sought care because of the onset of progressive dysphagia. He was found to have a perforated, fungating esophageal mass. The combined histologic and immunologic findings were diagnostic of Hodgkin's disease, nodular sclerosis type, lymphocyte-depleted variant, arising in the esophagus. The Reed-Sternberg cells and mononuclear variants were positive for Epstein-Barr virus (EBV) latent membrane protein (LMP1) and EBV RNA. Occasional small lymphoid cells were also positive for EBV RNA. Polymerase chain reaction studies demonstrated the presence of EBV type A without deletion of the EBV LMP1 gene. Other authors have reported an increased frequency of type B EBV and deletion of the EBV LMP1 gene in cases of human immunodeficiency virus-associated Hodgkin's disease. Hodgkin's disease arising in the esophagus is rare in immunocompetent patients. However, in the presence of AIDS, Hodgkin's disease should be considered in the differential diagnosis of patients with signs or symptoms of esophageal disease.
Gelb
A B
AB
Department of Pathology, University of California, San Francisco 94143-0102, USA.
Medeiros
L J
LJ
Chen
Y Y
YY
Weiss
L M
LM
Weidner
N
N
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000473:pathology; D001483:Base Sequence; D001707:Biopsy, Needle; D004273:DNA, Neoplasm / Q000032:analysis / Q000737:chemistry / Q000235:genetics; D004279:DNA, Viral / Q000032:analysis / Q000737:chemistry / Q000235:genetics; D003937:Diagnosis, Differential; D019309:Epstein-Barr Virus Nuclear Antigens / Q000235:genetics; D004938:Esophageal Neoplasms / Q000150:complications* / Q000175:diagnosis* / Q000473:pathology; D004947:Esophagus / Q000737:chemistry / Q000473:pathology; D004854:Herpesvirus 4, Human / Q000235:genetics; D006689:Hodgkin Disease / Q000150:complications* / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D016130:Immunophenotyping; D017730:Ki-1 Antigen / Q000032:analysis; D017493:Leukocyte Common Antigens / Q000032:analysis; D008099:Liver / Q000737:chemistry / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009841:Oligonucleotides / Q000032:analysis / Q000737:chemistry / Q000235:genetics; D016133:Polymerase Chain Reaction / Q000379:methods; D012333:RNA, Messenger / Q000032:analysis / Q000737:chemistry / Q000235:genetics; D014763:Viral Matrix Proteins / Q000235:genetics
D004273:DNA, Neoplasm; D004279:DNA, Viral; C037662:EBV-associated membrane antigen, Epstein-Barr virus; D019309:Epstein-Barr Virus Nuclear Antigens; D017730:Ki-1 Antigen; D009841:Oligonucleotides; D012333:RNA, Messenger; D014763:Viral Matrix Proteins; D017493:Leukocyte Common Antigens