title: A comparison of zopiclone and propiomazine as hypnotics in outpatients: a multicentre, double-blind, randomized, parallel-group comparison of zopiclone and propiomazine in insomniacs.
abstract: In a double-blind, parallel-group study of 135 patients with a mean age of 60 years, zopiclone 5 mg was compared with propiomazine 25 mg. The patients rated their sleep in a diary. There were statistically significant differences in favour of zopiclone for nine out of 13 variables measuring subjective sleep quality and quantity. Concerning side-effects, bad taste was reported more frequently in the zopiclone group and restless legs in the propiomazine group.
authors.affiliation: Department of Internal Medicine, Lund University Hospital, Sweden.
authors.forename: O
authors.initials: O
authors.lastname: Dehlin
authors.forename: C
authors.initials: C
authors.lastname: Bengtsson
authors.forename: B
authors.initials: B
authors.lastname: Rubin
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D053961:Azabicyclo Compounds; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010640:Phenothiazines / Q000627:therapeutic use*; D010879:Piperazines / Q000627:therapeutic use*; D012148:Restless Legs Syndrome / Q000139:chemically induced; D007319:Sleep Initiation and Maintenance Disorders / Q000188:drug therapy*; D013649:Taste / Q000187:drug effects
chemical_list: D014150:Antipsychotic Agents; D053961:Azabicyclo Compounds; D006993:Hypnotics and Sedatives; D010640:Phenothiazines; D010879:Piperazines; C515050:zopiclone; C084591:propiomazine