title: Differential expression of mammalian TRP homologues across tissues and cell lines.
abstract: Mammalian homologues of the Drosophila trp gene have been invoked as the structural basis for the currents associated with capacitative Ca2+ entry (CCE) in many cell types. Trp homologues are members of a large protein family that may associate as channel subunits providing an explanation for the functional diversity of store-operated channels observed in these cells. However, there is little information as to which of these genes are co-expressed at the cellular level. We have examined the tissue specific expression of five mammalian trp genes and determined which are co-expressed in five different cell lines. The results show tissue- and cell-specific co-expression of multiple trp forms. This implies that the subunit composition of a particular CCE channel may vary depending on the cell type.
authors.affiliation: Rammelkamp Center for Education and Research, Case Western Reserve University School of Medicine, Cleveland, Ohio 44109-1998, USA.
authors.forename: R L
authors.initials: RL
authors.lastname: Garcia
authors.forename: W P
authors.initials: WP
authors.lastname: Schilling
mesh_terms: D000818:Animals; D015139:Blotting, Southern; D015220:Calcium Channels / Q000096:biosynthesis* / Q000235:genetics; D002417:Cattle; D006801:Humans; D019169:Jurkat Cells; D008969:Molecular Sequence Data; D051381:Rats; D017207:Rats, Sprague-Dawley; D050052:TRPC Cation Channels
chemical_list: D015220:Calcium Channels; D050052:TRPC Cation Channels; C096351:transient receptor potential cation channel, subfamily C, member 1