title: Clinical value of CYFRA 8/18 and TPS in the diagnosis and follow up of invasive breast cancer.
abstract: In a prospective study, we evaluated the diagnostic accuracy of CYFRA 8/18, TPS, CEA and CA 15-3 among 415 patients in various clinical situations of invasive breast cancer and 244 women with benign breast diseases. In comparison to TPS, the sensitivity of CYFRA 8/18 was slightly lower as well in local malignancy (25% vs. 30%) as in metastatic cancer (54% vs. 57%), but in follow up care the rate of false positive results of TPA (> or = 25%) seems to be higher than that of CYFRA 8/18 (> or = 17%). In conclusion, the clinical value of CYFRA 8/18 and TPA appears to be similar.
authors.affiliation: Department of Gynecology and Obstetrics, University of Würzburg, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Sütterlin
authors.forename: M K
authors.initials: MK
authors.lastname: Oehler
authors.forename: H
authors.initials: H
authors.lastname: Caffier
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood*; D001943:Breast Neoplasms / Q000097:blood* / Q000175:diagnosis; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D010455:Peptides / Q000097:blood*
chemical_list: D014408:Biomarkers, Tumor; D010455:Peptides; C089984:tissue polypeptide specific antigen