The beta subunit, Kv beta 1.2, acts as a rapid open channel blocker of NH2-terminal deleted Kv1.4 alpha-subunits.
A recently discovered class of ancillary subunits has been shown to modify the inactivation properties of alpha-subunits belonging to the Kv1 family of potassium channels. One of these subunits, Kv beta 1.2, modifies intrinsic alpha-subunit C-type inactivation. N-type inactivation and open channel block have been proposed to increase the rate of development of C-type inactivation. We demonstrate here that Kv beta 1.2 has kinetic properties which are consistent with rapid open channel block.
Rasmusson
R L
RL
Department of Biomedical Engineering, School of Engineering, Duke University, Durham, NC 27708, USA.
Wang
S
S
Castellino
R C
RC
Morales
M J
MJ
Strauss
H C
HC
D000818:Animals; D003198:Computer Simulation; D004553:Electric Conductivity; D005289:Ferrets; D015640:Ion Channel Gating / Q000502:physiology; D007700:Kinetics; D051663:Kv1.2 Potassium Channel; D051665:Kv1.4 Potassium Channel; D046911:Macromolecular Substances; D015221:Potassium Channels / Q000737:chemistry / Q000502:physiology*; D024642:Potassium Channels, Voltage-Gated
D051663:Kv1.2 Potassium Channel; D051665:Kv1.4 Potassium Channel; D046911:Macromolecular Substances; D015221:Potassium Channels; D024642:Potassium Channels, Voltage-Gated