title: Family history and risk of fatal prostate cancer.
abstract: To examine the relation between fatal prostate cancer and family history of prostate cancer in a first-degree relative, we analyzed data from a prospective mortality study of 481,011 men with no history of cancer at enrollment in 1982. During 9 years of follow-up, 1,922 deaths from prostate cancer occurred. Results from Cox proportional hazard models showed that family history of prostate cancer was related to fatal prostate cancer [rate ratio (RR) = 1.60; 95% confidence interval (CI) = 1.31-1.97]; men with two or more affected relatives had a greater than threefold increase in risk (RR = 3.19; 95% CI = 1.51-6.71). Men whose relatives were diagnosed with prostate cancer before age 65 years (RR = 2.03; 95% CI = 1.33-3.09) had a greater effect of family history than men whose relatives were diagnosed at older ages (RR = 1.50; 95% CI = 1.17-1.91). Rate ratios did not increase with decreasing age of the study participants. The 60% increase in risk for men with at least one affected relative is lower than that reported in previous studies.
authors.affiliation: Department of Epidemiology & Surveillance Research, American Cancer Society, Atlanta, GA 30329-4251, USA.
authors.forename: C
authors.initials: C
authors.lastname: Rodríguez
authors.forename: E E
authors.initials: EE
authors.lastname: Calle
authors.forename: H L
authors.initials: HL
authors.lastname: Miracle-McMahill
authors.forename: L M
authors.initials: LM
authors.lastname: Tatham
authors.forename: P A
authors.initials: PA
authors.lastname: Wingo
authors.forename: M J
authors.initials: MJ
authors.lastname: Thun
authors.forename: C W
authors.initials: CW
authors.lastname: Heath
mesh_terms: D000328:Adult; D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D016001:Confidence Intervals; D005192:Family Health; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009679:Nuclear Family; D016017:Odds Ratio; D016016:Proportional Hazards Models; D011446:Prospective Studies; D011471:Prostatic Neoplasms / Q000235:genetics / Q000401:mortality*; D018570:Risk Assessment; D014481:United States / Q000453:epidemiology