Effect of salmon-calcitonin on in vitro opioid withdrawal.
The effect on the in vitro withdrawal sign induced by naloxone in morphine-dependent guinea pig ileum has been analyzed. Salmon calcitonin (s-CT) dose-dependently reduced the force of the contraction induced by naloxone in morphine incubated tissues, but did not modify the contraction induced by administration of acetylcholine or substance P in non-treated tissues. Therefore, the effect of s-CT in morphine incubated tissues may not be attributable to postsynaptic mechanisms, and an inhibitory modulation of the excitatory pathways triggered by naloxone would be suggested. In conclusion, s-CT is able to prevent the withdrawal sign in vitro.
Alfaro
M J
MJ
Departamento de Farmacología, Facultad de Medicina, Universidad Complutense de Madrid, Spain.
Fernández
B
B
Goicoechea
C
C
Martín
M I
MI
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology; D002116:Calcitonin / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004558:Electric Stimulation; D005071:Evoked Potentials / Q000187:drug effects; D006168:Guinea Pigs; D066298:In Vitro Techniques; D009020:Morphine / Q000009:adverse effects*; D009119:Muscle Contraction / Q000187:drug effects; D009270:Naloxone / Q000009:adverse effects*; D013375:Substance Withdrawal Syndrome / Q000188:drug therapy* / Q000503:physiopathology
D009270:Naloxone; D009020:Morphine; D002116:Calcitonin