title: Cervical sarcoma botryoides and ovarian Sertoli-Leydig cell tumor.
abstract: The case of a woman who developed a cervical sarcoma botryoides tumor at age 14 years and a right ovarian Sertoli-Leydig cell tumor with alpha-fetoprotein production at 27 years is presented. The sarcoma botryoides was a stage 1b, 4-cm, polypoid ectocervical tumor treated by radical hysterectomy and bilateral pelvic lymphadenectomy. The Sertoli-Leydig cell tumor was a stage 1a, 145-g mass removed piecemeal by right oophorectomy. Histologically, it was an intermediate Sertoli-Leydig cell tumor with a heterologous element composed of an endometrioid-like yolk sac tumor which was producing alpha-fetoprotein. There was no histological similarity between the two tumors. The patient is alive without evidence of disease, 16 years after diagnosis of her sarcoma botryoides and 3 years after her Sertoli-Leydig cell tumor. This is, to our knowledge, the third known association between these two rare gynecological tumors. The basis of the association remains unknown.
authors.affiliation: Department of Gynecological Oncology, Mercy Hospital for Women, Melbourne, Victoria, Australia.
authors.forename: P
authors.initials: P
authors.lastname: Golbang
authors.forename: A
authors.initials: A
authors.lastname: Khan
authors.forename: J
authors.initials: J
authors.lastname: Scurry
authors.forename: I
authors.initials: I
authors.lastname: MacIsaac
authors.forename: R
authors.initials: R
authors.lastname: Planner
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D010051:Ovarian Neoplasms / Q000097:blood / Q000473:pathology*; D018233:Rhabdomyosarcoma, Embryonal / Q000097:blood / Q000473:pathology*; D018310:Sertoli-Leydig Cell Tumor / Q000097:blood / Q000473:pathology*; D002583:Uterine Cervical Neoplasms / Q000097:blood / Q000473:pathology*; D000509:alpha-Fetoproteins / Q000032:analysis
chemical_list: D000509:alpha-Fetoproteins