title: Surgical treatment of epilepsy from schizencephaly with fused lips.
abstract: BACKGROUND
  Surgical treatment of schizencephaly with fused lips has been reported in few cases. In all of the previously reported cases, temporal lobectomy was selected as a major surgical treatment, except for one case with cortical resection. We present a case of direct resection of dysplastic walls of the schizencephalic cleft and the surrounding epileptic area.
  
  
  METHODS
  This 20-year-old college student with medication-resistant epilepsy was surgically treated by subpial cortical resection of the epileptogenic area around a schizencephalic cleft. Magnetic resonance imaging showed an unilateral schizencephalic cleft with fused lips in the right parietal lobe. Pathologic examination demonstrated dysplastic neurons in the epileptogenic cortex. Intraoperative electrocorticography clearly detected epileptiform discharges around the cleft, and the epileptogenic lesion was completely resected. He has been seizure-free for 1 year since the operation and he has no neurologic deficits.
  
  
  CONCLUSIONS
  Subpial resection of the dysplastic cortex surrounding the cleft under the guide of electrocorticography is an effective and minimally invasive procedure for the treatment of schizencephaly.
authors.affiliation: Tokyo Metropolitan Neurological Hospital, Department of Neurosurgery, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Maehara
authors.forename: H
authors.initials: H
authors.lastname: Shimizu
authors.forename: H
authors.initials: H
authors.lastname: Nakayama
authors.forename: M
authors.initials: M
authors.lastname: Oda
authors.forename: N
authors.initials: N
authors.lastname: Arai
mesh_terms: D000328:Adult; D002540:Cerebral Cortex / Q000473:pathology* / Q000503:physiopathology / Q000601:surgery*; D004569:Electroencephalography; D004827:Epilepsy / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D006801:Humans; D008297:Male; D016343:Monitoring, Intraoperative