Comparative study of CD26 as a Th1-like and CD30 as a potential Th2-like operational marker in leprosy.
In the last years we have been able to establish CD26 as an operational marker for a human Th1-like reaction in various granulomatous diseases. Recently, CD30 was described as a marker for a Th2-type reaction, where CD30 is preferentially expressed and its soluble form released by human T cell clones producing Th2-type cytokines. To evaluate the possibility of CD30 as an eventual operational marker for a human Th2-like reaction in vivo, we performed immunohistological stainings on frozen sections of skin biopsies from patients with lepromatous and tuberculoid leprosy. A maximum of three to four CD30-positive cells was found per section, and there was no difference in the accumulation of CD30-positive cells between the tuberculoid and the lepromatous form of leprosy. With respect to CD26-positive cells, a high number was found in tuberculoid leprosy in contrast to a greatly reduced expression of CD26 in lepromatous leprosy. We conclude that, while CD26 was confirmed as an operational marker for a Th1-like reaction in leprosy, CD30 does not represent an operational Th2 marker in this disease.
Seitzer
U
U
Department of Immunology and Cell Biology, Forschungszentrum Borstel, Germany.
Scheel-Toellner
D
D
Hahn
M
M
Heinemann
G
G
Mattern
T
T
Flad
H D
HD
Gerdes
J
J
D015415:Biomarkers; D018819:Dipeptidyl Peptidase 4 / Q000276:immunology*; D006801:Humans; D017730:Ki-1 Antigen / Q000276:immunology*; D007918:Leprosy / Q000276:immunology* / Q000503:physiopathology; D018417:Th1 Cells / Q000276:immunology*; D018418:Th2 Cells / Q000276:immunology*
D015415:Biomarkers; D017730:Ki-1 Antigen; D018819:Dipeptidyl Peptidase 4