[Effects of hormone replacement therapy in bone resorption, in post-menopausal women].
BACKGROUND
The effects of different therapies on bone loss rate can be measured using biochemical markers of bone resorption such as urinary hydroxyproline.


OBJECTIVE
To study the effects of hormone replacement therapy on urinary hydroxyproline in postmenopausal women.


METHODS
Eighty three postmenopausal women without hormone replacement therapy, 54 postmenopausal women receiving hormone replacement therapy and 16 premenopausal women (considered as the control group) were studied. Hydroxyproline was measured in an early morning urine sample, after one day of diet without meat or gelatin.


RESULTS
Urinary hydroxyproline in premenopausal women was 33.7 +/- 7.9 mg/g creatinine. The figure for postmenopausal women with hormonal replacement therapy was 33.7 +/- 5.9 mg/g creatinine. Postmenopausal women without replacement therapy had an urinary hydroxyproline of 47.4 +/- 8.5 mg/g creatinine, significantly higher than that of premenopausal and supplemented women. In 21 postmenopausal women, hydroxyproline was measured before and after three months of replacement therapy, values decreased 35.5 +/- 11% in this period and there was a direct correlation between initial values and the degree of reduction (r = 0.69, p < 0.001).


CONCLUSIONS
Postmenopausal women receiving hormone replacement therapy have a urinary hydroxyproline excretion similar to that of premenopausal women.
Villaseca
P
P
Departamento de Endocrinología, Facultad de Medicina, Pontificia Universidad Católica de Chile.
Arteaga
E
E
Campusano
C
C
López
J M
JM
Rojas
A
A
Nazar
G
G
O'Brien
A
A
D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D001862:Bone Resorption / Q000188:drug therapy* / Q000652:urine; D015914:Estrogen Replacement Therapy; D005260:Female; D006801:Humans; D006909:Hydroxyproline / Q000652:urine*; D008875:Middle Aged
D006909:Hydroxyproline