Mechanism of catalysis by retaining beta-glycosyl hydrolases.
Recent structural studies provide a fresh look at the catalytic mechanism of polysaccharide hydrolysis by retaining beta-glycosyl hydrolases. Highlights include insights into saccharide ring distortion, both upon binding and during the course of catalysis, and evidence for the regulation of the pKa of key catalytic residues.
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Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, MA 02254-9110, USA. awhite@auriga.rose.brandeis.edu
Rose
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D000345:Affinity Labels / Q000737:chemistry / Q000378:metabolism; D002236:Carbohydrate Conformation; D050260:Carbohydrate Metabolism; D002241:Carbohydrates / Q000737:chemistry*; D002384:Catalysis; D018360:Crystallography, X-Ray; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology; D004852:Epoxy Compounds / Q000378:metabolism / Q000494:pharmacology; D006026:Glycoside Hydrolases / Q000737:chemistry* / Q000378:metabolism*; D006027:Glycosides / Q000737:chemistry / Q000378:metabolism; D008958:Models, Molecular; D009113:Muramidase / Q000737:chemistry; D011487:Protein Conformation
D000345:Affinity Labels; D002241:Carbohydrates; D004791:Enzyme Inhibitors; D004852:Epoxy Compounds; D006027:Glycosides; D006026:Glycoside Hydrolases; D009113:Muramidase