title: Hepatotoxicity of diazepam. Structural and trace metal studies in rat.
abstract: Studies of effects of diazepam on liver parenchyma are very scanty. In this study, adult albino rats were treated with diazepam in two different doses (0.25 mg and 0.30 mg/kg body wt) daily for 30 and 60 d. Through light microscopy and electron microscopy, prenecrotic and necrotic changes were noted in the high-dose group. Trace metal analysis indicated that zinc (Zn) was reduced by 30 and 60 day under both the doses, whereas iron (Fe) and copper (Cu) were reduced significantly in these groups only after 60 d of treatment. This reduction in metal contents may have some correlations with necrotic changes in liver parenchyma.
authors.affiliation: Department of Anatomy, R. G. Kar Medical College, Calcutta, India.
authors.forename: S
authors.initials: S
authors.lastname: Chatterjee
authors.forename: J
authors.initials: J
authors.lastname: Chatterjee
authors.forename: K
authors.initials: K
authors.lastname: Chaudhuri
authors.forename: S
authors.initials: S
authors.lastname: Basu
authors.forename: C
authors.initials: C
authors.lastname: Maiti
mesh_terms: D000818:Animals; D056486:Chemical and Drug Induced Liver Injury; D003300:Copper / Q000032:analysis; D003975:Diazepam / Q000008:administration & dosage / Q000633:toxicity*; D007501:Iron / Q000032:analysis; D008099:Liver / Q000737:chemistry / Q000187:drug effects* / Q000473:pathology; D008107:Liver Diseases / Q000378:metabolism / Q000473:pathology; D008854:Microscopy, Electron; D051381:Rats; D013054:Spectrophotometry, Atomic; D014131:Trace Elements / Q000032:analysis*; D015032:Zinc / Q000032:analysis
chemical_list: D014131:Trace Elements; D003300:Copper; D007501:Iron; D015032:Zinc; D003975:Diazepam