title: [Current status of low-dose CDDP. 5-FU therapy for solid malignant tumors--nationwide questionnaire survey].
abstract: A nation-wide questionnaire survey was undertaken concerning low-dose anticancer therapy of CDDP plus 5-FU, which involves (5-10 mg CDDP/body/day + 300-500 mg/body/day) for 4-6 weeks. Out of 1,525 cases from 130 institutions, 847 cases with evaluable lesions were collected from 79 institutions. The response rate was 56.4% in esophageal cancer, 34.3% in gastric cancer, 35.3% in colorectal cancer, 47.2% in liver cancer and 35.9% in lung cancer, respectively. Adverse effects were found to be fewer and compliance was much better than the conventional therapy. Such figures suggest that the present regimen may be more effective than any so far. Problems for medical administration such as unlicensed CDDP for colorectal cancer were pointed out, which hinder the forthcoming third phase study.
authors.affiliation: Second Dept. of Surgery, Gifu University School of Medicine.
authors.forename: S
authors.initials: S
authors.lastname: Saji
authors.forename: K
authors.initials: K
authors.lastname: Aiba
authors.forename: H
authors.initials: H
authors.lastname: Araki
authors.forename: K
authors.initials: K
authors.lastname: Sasaki
authors.forename: T
authors.initials: T
authors.lastname: Shirasaka
authors.forename: M
authors.initials: M
authors.lastname: Sowa
authors.forename: M
authors.initials: M
authors.lastname: Tanaka
authors.forename: Y
authors.initials: Y
authors.lastname: Chung
authors.forename: T
authors.initials: T
authors.lastname: Toge
authors.forename: K
authors.initials: K
authors.lastname: Hirata
authors.forename: K
authors.initials: K
authors.lastname: Yasumoto
authors.forename: S
authors.initials: S
authors.lastname: Yamamitsu
authors.forename: H
authors.initials: H
authors.lastname: Wada
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D002945:Cisplatin / Q000008:administration & dosage; D015179:Colorectal Neoplasms / Q000188:drug therapy; D004334:Drug Administration Schedule; D004938:Esophageal Neoplasms / Q000188:drug therapy; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy; D008175:Lung Neoplasms / Q000188:drug therapy; D009369:Neoplasms / Q000188:drug therapy*; D011795:Surveys and Questionnaires
chemical_list: D002945:Cisplatin; D005472:Fluorouracil