Genetic counselling in mitochondrial diseases.
Mitochondrial disorders may be caused by mutations either in mitochondrial or in nuclear genes involved in the synthesis or regulation of respiratory chain subunits. The unique nature of the mitochondrial genome calls for a different approach to genetic counselling and risk analysis.
Warner
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TT
Royal Free Hospital School of Medicine, London, UK.
Schapira
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AH
D004252:DNA Mutational Analysis; D004579:Electron Transport / Q000235:genetics; D005817:Genetic Counseling; D006801:Humans; D017237:Mitochondrial Encephalomyopathies / Q000145:classification / Q000175:diagnosis / Q000235:genetics*; D011379:Prognosis; D018570:Risk Assessment