Structure of benzyl T-antigen disaccharide bound to Amaranthus caudatus agglutinin.
Amaranthus caudatus agglutinin contains a novel arrangement of four beta-trefoil domains. The sugar-binding site provides specificity for the carcinoma-associated T-antigen disaccharide even when 'masked' by other sugars.
Transue
T R
TR
Smith
A K
AK
Mo
H
H
Goldstein
I J
IJ
Saper
M A
MA
D000957:Antigens, Viral, Tumor / Q000737:chemistry*; D001593:Benzyl Compounds; D018360:Crystallography, X-Ray / Q000379:methods; D019281:Dimerization; D004187:Disaccharides; D002523:Edible Grain; D037102:Lectins / Q000737:chemistry*; D008958:Models, Molecular; D037121:Plant Lectins; D011487:Protein Conformation; D054788:Ribosome Inactivating Proteins; D054789:Ribosome Inactivating Proteins, Type 1; D012639:Seeds
D000957:Antigens, Viral, Tumor; D001593:Benzyl Compounds; D004187:Disaccharides; D037102:Lectins; D037121:Plant Lectins; D054789:Ribosome Inactivating Proteins, Type 1; C061152:amaranthin protein, Amaranthus; D054788:Ribosome Inactivating Proteins