Fatal hepatic necrosis after isoflurane anaesthesia.
Several halogenated anaesthetic agents have been associated with hepatotoxicity. We report a case of fulminant, fatal hepatic necrosis after uneventful isoflurane anaesthesia in a patient without previous liver disease, who may have been sensitised by previous exposure to enflurane. Although no anti-trifluoroacetyl antibodies could be detected in the patient's serum, isoflurane hepatotoxicity seems very likely to be the reason for fulminant hepatic failure in this patient.
Weitz
J
J
Department of Surgery, University of Heidelberg, Germany.
Kienle
P
P
Böhrer
H
H
Hofmann
W
W
Theilmann
L
L
Otto
G
G
D000328:Adult; D018685:Anesthetics, Inhalation / Q000009:adverse effects*; D017809:Fatal Outcome; D005260:Female; D006501:Hepatic Encephalopathy / Q000139:chemically induced*; D006801:Humans; D007530:Isoflurane / Q000009:adverse effects*; D008099:Liver / Q000473:pathology*; D009336:Necrosis
D018685:Anesthetics, Inhalation; D007530:Isoflurane