title: CYP1A1 and GSTM1 polymorphisms and oral cancer risk.
abstract: The importance of both the CYP1A1 exon 7 (ile:val) and GSTM1 (0/0) polymorphisms in oral cancer susceptibility was assessed by examining polymorphic prevalences in 135 patients with oral cancer and 135 noncancer controls frequency-matched by age at diagnosis (+/- 5 years), race, sex, and institute of patient recruitment. The prevalence of the GSTM1 (0/0) genotype was approximately 51% in both cases and controls. The prevalence of the CYP1A1 (ile:val) polymorphism [including both the (ile/val) and (val/val) genotypes] was significantly higher in cases as compared to controls (17.6% versus 7.6%, respectively; crude odds ratio, 2.6; confidence interval, 1.2-5.7). No association was observed between polymorphic prevalence and levels of smoking or alcohol consumption in cases. These results suggest that the GSTM1 null genotype is not associated with oral cancer risk. These results also suggest that individuals with the CYP1A1 exon 7 ile:val polymorphism are at increased risk for oral cancer, and that this risk may not be influenced by differences in exposure to tobacco smoke.
authors.affiliation: Department of Pathology, School of Medicine, Temple University, Philadelphia, Pennsylvania 19140, USA.
authors.forename: J Y
authors.initials: JY
authors.lastname: Park
authors.forename: J E
authors.initials: JE
authors.lastname: Muscat
authors.forename: Q
authors.initials: Q
authors.lastname: Ren
authors.forename: S P
authors.initials: SP
authors.lastname: Schantz
authors.forename: R D
authors.initials: RD
authors.lastname: Harwick
authors.forename: J C
authors.initials: JC
authors.lastname: Stern
authors.forename: V
authors.initials: V
authors.lastname: Pike
authors.forename: J P
authors.initials: JP
authors.lastname: Richie
authors.forename: P
authors.initials: P
authors.lastname: Lazarus
mesh_terms: D000328:Adult; D000368:Aged; D000428:Alcohol Drinking; D002294:Carcinoma, Squamous Cell / Q000201:enzymology / Q000453:epidemiology / Q000235:genetics*; D016022:Case-Control Studies; D019363:Cytochrome P-450 CYP1A1 / Q000235:genetics*; D005260:Female; D005838:Genotype; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D007822:Laryngeal Neoplasms / Q000201:enzymology / Q000453:epidemiology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000201:enzymology / Q000453:epidemiology / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012307:Risk Factors; D012907:Smoking; D044465:White People / Q000235:genetics
chemical_list: D019363:Cytochrome P-450 CYP1A1; D005982:Glutathione Transferase