Molecular and biological constraints on ligand-binding affinity and specificity.
Interactions between biological macromolecules have characteristic values of affinity and specificity that are set according to the biological function that is served by the interaction in the organism. Here we examine the molecular mechanisms that are used to achieve the required values of affinity and specificity in various biological systems.
Szwajkajzer
D
D
Princeton University, Department of Chemistry, NJ 08544, USA.
Carey
J
J
D004247:DNA / Q000737:chemistry* / Q000378:metabolism*; D007700:Kinetics; D008024:Ligands; D046911:Macromolecular Substances; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism*; D013379:Substrate Specificity; D013816:Thermodynamics
D008024:Ligands; D046911:Macromolecular Substances; D011506:Proteins; D004247:DNA