title: Unexplained neurologic deficit after uneventful combined spinal and epidural anesthesia for cesarean delivery.
abstract: OBJECTIVE
  Neurologic deficits after spinal and epidural anesthesia are uncommon and have a variety of pathophysiologic mechanisms. Local anesthetic neurotoxicity may occur, although subarachnoid bupivacaine has an unblemished clinical record.
  
  
  METHODS
  A healthy parturient underwent uneventful combined spinal and epidural anesthesia for elective cesarean delivery. Intraspinal drugs administered included hyperbaric bupivacaine 0.5% and fentanyl (subarachnoid) and 2% lidocaine with epinepherine 1:200,000 and meperidine (epidural).
  
  
  RESULTS
  On the third postpartum day the patient reported buttock numbness. An area of hypoesthesia in the distribution of the lower sacral nerves was present, without systemic or other neurologic symptoms and signs. The deficit persisted, and imaging of the lower spinal canal revealed no significant abnormality. Full recovery of sensation occurred after 7 months.
  
  
  CONCLUSIONS
  Drug-induced neurotoxicity is a possible explanation, although the exact etiology is uncertain.
authors.affiliation: Department of Anaesthesia, King Edward Memorial Hospital for Women, Perth, Western Australia.
authors.forename: M J
authors.initials: MJ
authors.lastname: Paech
mesh_terms: D000328:Adult; D000767:Anesthesia, Epidural / Q000009:adverse effects; D000773:Anesthesia, Obstetrical / Q000009:adverse effects; D000775:Anesthesia, Spinal / Q000009:adverse effects; D002585:Cesarean Section; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D009422:Nervous System Diseases / Q000209:etiology*; D011183:Postoperative Complications / Q000503:physiopathology; D011247:Pregnancy