title: Failure to block adhesion of Plasmodium falciparum-infected erythrocytes to ICAM-1 with soluble ICAM-1.
abstract: The adhesion of Plasmodium falciparum-infected erythrocytes is thought to play a central role in the pathogenesis of severe malaria. ICAM-1 has been identified as one of the host receptors for parasitized erythrocytes and has been implicated as being involved in progression to cerebral malaria. Thus, intervention strategies based on the reversal of this interaction could potentially be used to reduce morbidity and mortality. We have investigated the inhibition of the interaction between ICAM-1 and infected erythrocytes by using recombinant soluble ICAM-1 as competitor and find that we are unable to reduce adhesion to ICAM-1 in vitro.
authors.affiliation: Molecular Parasitology Group, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, United Kingdom. acraig@hammer.imm.ox.ac.uk
authors.forename: A G
authors.initials: AG
authors.lastname: Craig
authors.forename: R
authors.initials: R
authors.lastname: Pinches
authors.forename: S
authors.initials: S
authors.lastname: Khan
authors.forename: D J
authors.initials: DJ
authors.lastname: Roberts
authors.forename: G D
authors.initials: GD
authors.lastname: Turner
authors.forename: C I
authors.initials: CI
authors.lastname: Newbold
authors.forename: A R
authors.initials: AR
authors.lastname: Berendt
mesh_terms: D000818:Animals; D019556:COS Cells; D002448:Cell Adhesion; D004912:Erythrocytes / Q000469:parasitology* / Q000502:physiology; D018799:Intercellular Adhesion Molecule-1 / Q000502:physiology*; D010963:Plasmodium falciparum / Q000502:physiology*; D011994:Recombinant Proteins / Q000494:pharmacology
chemical_list: D011994:Recombinant Proteins; D018799:Intercellular Adhesion Molecule-1