title: Combined-modality therapy of head and neck cancer.
abstract: The treatment of head and neck cancer has traditionally consisted of surgery with postoperative radiation therapy. Chemotherapy has been reserved for palliation. In recent years, induction chemotherapy has been shown to allow for larynx preservation in patients with laryngeal or hypopharyngeal cancer. Concomitant chemoradiotherapy has been shown to provide a statistically significant survival benefit in selected studies and recent meta-analyses. In patients with nasopharyngeal cancer, the use of cisplatin and concomitant radiation therapy results in a marked survival benefit.
authors.affiliation: University of Chicago, Cancer Research Center, Illinois, USA.
authors.forename: E E
authors.initials: EE
authors.lastname: Vokes
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D002945:Cisplatin / Q000627:therapeutic use; D003131:Combined Modality Therapy; D006258:Head and Neck Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D006801:Humans; D009303:Nasopharyngeal Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000628:therapy; D011182:Postoperative Care; D011859:Radiography; D016032:Randomized Controlled Trials as Topic
chemical_list: D000970:Antineoplastic Agents; D002945:Cisplatin