Osteoporosis due to testicular atrophy in male leprosy patients.
A study was conducted to examine the relationship of testicular atrophy to bone metabolism in male leprosy patients. The study consisted of 31 leprosy patients (mean age: 62.0 years) and 31 healthy control men (mean age: 60.0 years). Measurements were made of their serum levels of free testosterone (FT), estradiol (E2), luteinizing hormone (LH) and 25-hydroxyvitamin D (25 OHD). Bone mineral density (BMD) was measured at radial sites and the lumbar vertebral bodies (L2-L4) by dual-energy X-ray absorptiometry using a Hologic QDR-2000 densitometer. FT and E2 levels were significantly lower and LH levels higher in leprosy patients than in controls. This represents a primary hypogonadal pattern. A value of 7.20 pg/ml of FT ( = Mean - 1 SD of control) was used as a cut off value, and the subjects were subdivided into a hypogonadal group (HG) and a non hypogonadal group (non-HG). When the subjects were compared for differences in age, age at onset of disease, duration of disease, body mass index and BMD, only the duration of disease and BMD were significantly different between the two groups. Furthermore, BMD of the forearm significantly correlated with FT levels (r = 0.689, P < 0.0001). Low BMD may be due to orchitis and testicular atrophy.
Ishikawa
S
S
Department of Orthopaedic Surgery, Okayama University Medical School, Japan.
Tanaka
H
H
Mizushima
M
M
Hashizume
H
H
Ishida
Y
Y
Inoue
H
H
D000368:Aged; D001284:Atrophy; D015519:Bone Density; D004958:Estradiol / Q000097:blood; D006801:Humans; D007918:Leprosy / Q000150:complications*; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis / Q000209:etiology*; D013737:Testis / Q000473:pathology*; D013739:Testosterone / Q000097:blood
D013739:Testosterone; D004958:Estradiol; D007986:Luteinizing Hormone