title: Ki-67 antigen in ameloblastomas: correlation with clinical and histological parameters in 54 cases from Kenya.
abstract: The aim of this study was to assess the cell proliferation in ameloblastomas and to correlate this with clinical features and histology. Immunohistochemistry with Ki-67 monoclonal antibody was performed on fresh tissue from 54 ameloblastomas. A labelling index (LI) was calculated by expressing the percentage of Ki-67 positive cells. There was no significant correlation between LI and clinical features: age, sex or tumour size. Follicular ameloblastomas had significantly higher LI (5.0 +/- 0.5; mean +/- SEM) than plexiform tumours (3.2 +/- 0.6; P < 0.05). Plexiform ameloblastomas from the anterior mandible had a significantly lower LI (1.8 +/- 0.5) than those from the posterior (3.9 +/- 0.8; P < 0.05). LI was higher in squamous arcades (6.4 +/- 3.1%) than in epithelial cords and cysts (1.4 +/- 1.3%; P < 0.001). These results suggest that LI correlates most closely with the histological pattern of the epithelium of ameloblastoma, both within and between different tumours.
authors.affiliation: Department of Oral Pathology, St Bartholomew's and the Royal London School of Medicine and Dentistry, UK.
authors.forename: M N
authors.initials: MN
authors.lastname: Ong'uti
authors.forename: A T
authors.initials: AT
authors.lastname: Cruchley
authors.forename: G L
authors.initials: GL
authors.lastname: Howells
authors.forename: D M
authors.initials: DM
authors.lastname: Williams
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000564:Ameloblastoma / Q000145:classification / Q000473:pathology*; D000911:Antibodies, Monoclonal; D002455:Cell Division; D002467:Cell Nucleus / Q000648:ultrastructure; D002648:Child; D003560:Cysts / Q000473:pathology; D004848:Epithelium / Q000473:pathology; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D007630:Kenya; D019394:Ki-67 Antigen / Q000032:analysis*; D008297:Male; D008339:Mandibular Neoplasms / Q000473:pathology*; D008441:Maxillary Neoplasms / Q000473:pathology; D008875:Middle Aged; D012737:Sex Factors
chemical_list: D000911:Antibodies, Monoclonal; D019394:Ki-67 Antigen