title: Pathophysiology of fever. Part 2: Relooking at cooling interventions.
abstract: Presently, fever is thought to play a beneficial role in the control and containment of infection by curtailing virus replication, enhancing natural killer cell activity, and killing of natural killer-resistant leukemia cells. The first article in this set of articles on fever physiology, which was printed in a previous issue, covered the role of cytokines in fever. This article expands the physiology to describe the body's positive response to fever, so critical care nurses can decide which patients to cool, which ones not to cool, and how to revise cooling protocols.
authors.affiliation: University of North Carolina at Chapel Hill, School of Nursing, USA.
authors.forename: P J
authors.initials: PJ
authors.lastname: Rowsey
mesh_terms: D003422:Critical Care / Q000379:methods; D017679:Cryotherapy; D005334:Fever / Q000451:nursing / Q000503:physiopathology* / Q000628:therapy*; D006801:Humans; D009730:Nursing Assessment