title: The effect of starvation on brain carnitine concentration in neonatal rats.
abstract: BACKGROUND
  We examined carnitine concentrations in fasted neonatal rat brain to evaluate the effect of starvation on fatty acid metabolism.
  
  
  METHODS
  The free- and acylcarnitine concentrations in neonatal rat brain and heart were determined after a 72-hour starvation period from the 3rd to 6th postnatal day. They were also determined in rats at 3 and 6 days of age fed normally by the mother rats as controls.
  
  
  RESULTS
  In the brain, the mean free carnitine concentration in the fasted group showed an increase similar to that in normal rats and there was no difference between the fasted and 6-day-old control rats. However, the mean acylcarnitine concentration was significantly higher in the fasted group than in the control group at both 3 and 6 days of age. Almost all of the increased acylcarnitine in the fasted group was short-chain acylcarnitine. In the heart, there was no difference in the mean free carnitine concentration between the fasted group and control group at 6 days of age. The 6-day-old rats in both the fasted and control groups showed higher levels compared to 3-day-old rats in the control group. The mean acylcarnitine concentration in the fasted group was not different from that in control group at 6 days of age, while the amount of short-chain acylcarnitine was less than that in the control group at 6 days of age.
  
  
  CONCLUSIONS
  These findings suggest that in the brain, carnitine is accumulated as a result of redistribution during starvation, and is utilized for energy supply by fatty acid oxidation.
authors.affiliation: Department of Pediatrics, Awaji Prefectural Hospital, Hyougo-ken, Japan.
authors.forename: R
authors.initials: R
authors.lastname: Murakami
authors.forename: A
authors.initials: A
authors.lastname: Tanaka
authors.forename: H
authors.initials: H
authors.lastname: Nakamura
mesh_terms: D000375:Aging / Q000378:metabolism; D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000033:anatomy & histology; D001923:Brain Chemistry; D002331:Carnitine / Q000032:analysis* / Q000378:metabolism; D005227:Fatty Acids / Q000032:analysis / Q000378:metabolism; D006321:Heart / Q000033:anatomy & histology; D009206:Myocardium / Q000737:chemistry; D009929:Organ Size; D051381:Rats; D017208:Rats, Wistar; D013217:Starvation / Q000503:physiopathology*; D015430:Weight Gain / Q000502:physiology
chemical_list: D005227:Fatty Acids; D002331:Carnitine