Indonesian medicinal plants. XXI. Inhibitors of Na+/H+ exchanger from the bark of Erythrina variegata and the roots of Maclura cochinchinensis.
Through bioassay-guided separation of the methanol extracts of Indonesian medicinal plants, three inhibitors of the Na+/H+ exchange system, erythrinin B (2), euchrenone b10 (3), and 1,3,5-trihydroxy-4-(3-methylbut-2-enyl)xanthen-9-one (4), were isolated from the bark of Erythrina variegata (Fabaceae) (for 2) and the roots of Maclura cochinchinensis (Moraceae) (for 2, 3, 4). Compounds 2, 3, and 4 significantly inhibited the Na+/H+ exchange system of arterial smooth muscle cells, with minimum inhibitory concentrations of 1.25, 1.25, and 10 micrograms/ml, respectively. Three new prenylated xanthones named isocudraniaxanthones B (5) and A (7) and isoalvaxanthone (9) were also isolated from M. cochinchinensis and the chemical structures were elucidated on the bases of their chemical and physicochemical properties.
Kobayashi
M
M
Faculty of Pharmaceutical Sciences, Osaka University, Suita, Japan.
Mahmud
T
T
Yoshioka
N
N
Shibuya
H
H
Kitagawa
I
I
D000818:Animals; D002478:Cells, Cultured; D004895:Erythrina; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification*; D007214:Indonesia; D007529:Isoflavones / Q000737:chemistry / Q000302:isolation & purification*; D037102:Lectins / Q000737:chemistry / Q000302:isolation & purification*; D009682:Magnetic Resonance Spectroscopy; D009131:Muscle, Smooth, Vascular / Q000187:drug effects* / Q000378:metabolism; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology; D037121:Plant Lectins; D018517:Plant Roots; D010946:Plants, Medicinal; D051381:Rats; D011918:Rats, Inbred SHR; D017923:Sodium-Hydrogen Exchangers / Q000037:antagonists & inhibitors*; D014966:Xanthenes / Q000737:chemistry / Q000302:isolation & purification*; D044004:Xanthones
C109429:1,3,5-trihydroxy-4-(3-methylbut-2-enyl)xanthen-9-one; D005663:Furans; D007529:Isoflavones; D037102:Lectins; D010936:Plant Extracts; D037121:Plant Lectins; D017923:Sodium-Hydrogen Exchangers; D014966:Xanthenes; D044004:Xanthones; C045629:erythrina lectin; C109428:euchrenone b10