Increased beta adrenoceptor activation overcomes conditioned olfactory learning deficits induced by serotonin depletion.
It was hypothesized that 5-HT2 receptors in the olfactory bulb prime the bulbar response to a beta adrenoceptor mediated unconditioned stimulus (UCS) during odor preference learning in 1-week-old rat pups. The ability of 4 mg/kg of isoproterenol + stroking and 6 mg/kg of isoproterenol + no stroking to induce normal odor preference learning in pups depleted of bulbar 5-HT in the present study supports the hypothesis. The inverted-U curve relation between UCS strength and learning also appears to occur within the bulb.
Langdon
P E
PE
Division of Basic Medical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St. John's, Canada.
Harley
C W
CW
McLean
J H
JH
D000318:Adrenergic beta-Agonists / Q000494:pharmacology; D000704:Analysis of Variance; D000818:Animals; D002755:Choice Behavior / Q000187:drug effects; D003214:Conditioning, Classical / Q000187:drug effects*; D007545:Isoproterenol / Q000494:pharmacology; D007859:Learning Disabilities / Q000503:physiopathology*; D009812:Odorants; D009830:Olfactory Bulb / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D011943:Receptors, Adrenergic, beta / Q000502:physiology*; D012701:Serotonin / Q000172:deficiency*
D000318:Adrenergic beta-Agonists; D011943:Receptors, Adrenergic, beta; D012701:Serotonin; D007545:Isoproterenol