title: A protein particle vaccine containing multiple malaria epitopes.
abstract: Ty virus-like particles consist of a single protein species that can be produced in yeast. Recombinant Ty-VLPs carrying a string of up to 15 defined cytotoxic T lymphocyte (CTL) epitopes from Plasmodium species prime protective CTL responses in mice following a single administration without adjuvant. Effective processing of epitopes from the string was demonstrated in vitro and in vivo and was not affected by flanking sequences.
authors.affiliation: Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, UK.
authors.forename: S C
authors.initials: SC
authors.lastname: Gilbert
authors.forename: M
authors.initials: M
authors.lastname: Plebanski
authors.forename: S J
authors.initials: SJ
authors.lastname: Harris
authors.forename: C E
authors.initials: CE
authors.lastname: Allsopp
authors.forename: R
authors.initials: R
authors.lastname: Thomas
authors.forename: G T
authors.initials: GT
authors.lastname: Layton
authors.forename: A V
authors.initials: AV
authors.lastname: Hill
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000939:Epitopes / Q000737:chemistry* / Q000276:immunology; D005260:Female; D006801:Humans; D017780:Malaria Vaccines / Q000737:chemistry* / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D008969:Molecular Sequence Data; D010962:Plasmodium berghei / Q000276:immunology; D010963:Plasmodium falciparum / Q000276:immunology*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology
chemical_list: D000939:Epitopes; D017780:Malaria Vaccines