Response to hepatitis A vaccination in human immunodeficiency virus-infected and -uninfected homosexual men.
The influence of human immunodeficiency virus (HIV) infection and vaccination schedule on the immunogenicity of a hepatitis A vaccine was examined. Ninety HIV-infected homosexual men received two vaccinations with hepatitis A vaccine (each 2 mL of 720 ELISA units/mL) either 1 or 6 months apart; 44 HIV-uninfected men received vaccine at study entry and at 6 months. Anti-hepatitis A virus (HAV) titer after vaccination was measured in 83 HIV-positive and 39 HIV-negative men. Seroconversion (anti-HAV antibody > or = 20 IU/L) after two vaccinations occurred more frequently in HIV-negative men (100% vs. 88.2%; P = .03). Anti-HAV titer after two vaccinations was also significantly greater in HIV-negative men (1086 vs. 101 IU/L; P = .0001). HIV-positive men who responded to vaccination had significantly more CD4 lymphocytes (mean, 540/microL) at baseline than those who did not (280/microL; P = .033). Vaccine schedule did not affect response. Vaccination of susceptible patients against HAV should be recommended early in HIV infection using the shorter course to encourage compliance.
Neilsen
G A
GA
Sydney Sexual Health Centre, Sydney Hospital, NSW, Australia.
Bodsworth
N J
NJ
Watts
N
N
D000328:Adult; D018791:CD4 Lymphocyte Count; D015658:HIV Infections / Q000276:immunology*; D018023:HIV Seronegativity; D006679:HIV Seropositivity; D006506:Hepatitis A / Q000276:immunology* / Q000517:prevention & control*; D017957:Hepatitis A Virus, Human / Q000276:immunology; D006508:Hepatitis Antibodies / Q000032:analysis; D018451:Homosexuality, Male; D006801:Humans; D016867:Immunocompromised Host; D008297:Male; D014611:Vaccination; D015164:Vaccines, Inactivated / Q000008:administration & dosage / Q000276:immunology*
D006508:Hepatitis Antibodies; D015164:Vaccines, Inactivated