Metabolic bone status in young women with JCA.
The study was based on clinical, densitometric and biochemical evaluations and on a life-style questionnaire, applied in a cohort of 41 individuals. The mean age of the young women was 24.2 (18-36) years. The main point was to compare subgroups with (CS) an without (NCS) corticosteroid treatment (19 and 22 patients, respectively). There was no significant difference in age, weight and duration of JCA. Of the densitometric examinations, spine DXA (DPX-L LUNAR apparatus) yielded values significantly lower in CS than in NCS individuals (p = 0.05). Much more apparent was the difference in stiffness measurements in the calcanei performed by Achilles-LUNAR ultrasound instrument, again with lower values in CS women (p = 0.001) (Fig. 1, 2, 3). No significant differences were found between the two subgroups as regards blood levels of bone alkaline phosphatase, osteocalcin and tartrate-resistant acidic phosphatase, and urine hydroxyproline output. Menarche occurred at a mean age of 14.37 years in the CS subgroup (p = 0.01, against healthy population) and of 13.32 years in the NCS subgroup (not significant). The prevalence of fractures was enconsiderable in both subgroups. These findings are to be understood from the viewpoint of combined influences of both disease activity and corticotherapy in the CS patients with JCA.
Havelka
S
S
Institute of Rheumatology, Charles University, Prague, Czech Republic.
Vavrincová
P
P
Stĕpán
J
J
Hladíková
M
M
D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000009:adverse effects; D000328:Adult; D001171:Arthritis, Juvenile / Q000188:drug therapy / Q000378:metabolism* / Q000503:physiopathology; D015519:Bone Density / Q000187:drug effects; D015331:Cohort Studies; D005260:Female; D006801:Humans
D000305:Adrenal Cortex Hormones