title: Effects of pulsatile flow on gas transfer of membrane oxygenator: MENOX EL-4000 and Gyro C1-E3 pulsatile mode.
abstract: It is acknowledged that pulsatile flow enhances the gas exchange performance of membrane oxygenators. However, the data for currently developed oxygenators are limited. In this study, the effect of pulsatile flow was assessed utilizing the MENOX EL-4000 oxygenator. The in vitro test was performed following the Association for the Advancement of Medical Instrumentation (AAMI) standards. Pulsatile flow was produced by the Gyro C1-E3 centrifugal pump with periodical changing of the impeller speed. In Study 1, the following 3 groups were created and examined: nonpulsatile flow, pulsatile flow of 40 bpm, and pulsatile flow of 60 bpm. The blood flow rate was maintained at 3 L/min, and the V/Q ratio was 1. In Study 2, four groups were examined, nonpulsatile flow with V/Q = 1, nonpulsatile with V/Q = 2, pulsatile with V/Q = 1, and pulsatile with V/Q = 2. The blood flow rate was maintained at 4 L/min, and the pulse frequency was set at 40 bpm. In study 1, although O2 transfer was not enhanced, CO2 transfer was significantly improved (40-50%) by pulsatile flow, regardless of pulse frequency. Study 2 demonstrated that pulsatile flow resulted in improved CO2 transfer as did higher ventilation (V/Q = 2). Furthermore, even after applying higher ventilation, the pulsatile mode enhanced CO2 transfer more than the nonpulsatile mode. It was considered that the pulsatile mode induced an active secondary flow and enhanced mixing effects, and consequently CO2 transfer was improved. In conclusion, the pulsatile flow significantly enhanced the CO2 transfer of the MENOX oxygenator. It is indicated that applying the pulsatile mode is a unique and effective method to improve the gas exchange performance for a current membrane oxygenator.
authors.affiliation: Department of Surgery, Baylor College of Medicine, Houston, Texas, U.S.A.
authors.forename: E
authors.initials: E
authors.lastname: Tayama
authors.forename: Y
authors.initials: Y
authors.lastname: Niimi
authors.forename: Y
authors.initials: Y
authors.lastname: Takami
authors.forename: Y
authors.initials: Y
authors.lastname: Ohashi
authors.forename: G
authors.initials: G
authors.lastname: Ohtsuka
authors.forename: T
authors.initials: T
authors.lastname: Nakazawa
authors.forename: J A
authors.initials: JA
authors.lastname: Glueck
authors.forename: J
authors.initials: J
authors.lastname: Müller
authors.forename: Y
authors.initials: Y
authors.lastname: Nosé
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D002245:Carbon Dioxide; D002417:Cattle; D002498:Centrifugation; D015199:Extracorporeal Membrane Oxygenation; D008962:Models, Theoretical; D010100:Oxygen; D010107:Oxygenators, Membrane; D011659:Pulmonary Gas Exchange; D011673:Pulsatile Flow
chemical_list: D002245:Carbon Dioxide; D010100:Oxygen