title: Celiac disease transmitted by allogeneic non-T cell-depleted bone marrow transplantation.
abstract: We observed the occurrence of celiac disease following allogeneic bone marrow transplantation in a patient transplanted for acute leukemia. The marrow donor was his HLA-identical sister, who had suffered from celiac disease since birth. The post-transplant period was characterized by recurrent episodes of diarrhea. Detailed workup showed atrophic intestinal mucosa on histology and anti-gliadin and anti-endomysium antibodies in the serum, features that were not present before transplantation. GVHD was absent at that time. The patient remains free of symptoms on gluten-free diet and slight immunosuppression. This case suggests transmission of celiac disease by bone marrow transplantation and supports the T cell concept in celiac disease.
authors.affiliation: Department of Internal Medicine, Kantonsspital Basel, Switzerland.
authors.forename: M J
authors.initials: MJ
authors.lastname: Bargetzi
authors.forename: A
authors.initials: A
authors.lastname: Schönenberger
authors.forename: A
authors.initials: A
authors.lastname: Tichelli
authors.forename: R
authors.initials: R
authors.lastname: Fried
authors.forename: G
authors.initials: G
authors.lastname: Cathomas
authors.forename: E
authors.initials: E
authors.lastname: Signer
authors.forename: B
authors.initials: B
authors.lastname: Speck
authors.forename: A
authors.initials: A
authors.lastname: Gratwohl
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D002446:Celiac Disease / Q000209:etiology* / Q000276:immunology; D006801:Humans; D007938:Leukemia / Q000628:therapy*; D008212:Lymphocyte Depletion; D008297:Male; D013601:T-Lymphocytes / Q000276:immunology; D014184:Transplantation, Homologous