title: Catechol O-methyltransferase: characterization of the protein, its gene, and the preclinical pharmacology of COMT inhibitors.
authors.affiliation: Department of Pharmacology and Toxicology, University of Kuopio, Finland.
authors.forename: P T
authors.initials: PT
authors.lastname: Männistö
mesh_terms: D000578:Amidines / Q000494:pharmacology*; D000818:Animals; D000978:Antiparkinson Agents / Q000494:pharmacology*; D001577:Benzophenones / Q000494:pharmacology*; D001921:Brain / Q000201:enzymology; D002394:Catechol O-Methyltransferase / Q000235:genetics* / Q000378:metabolism*; D065098:Catechol O-Methyltransferase Inhibitors; D002396:Catechols / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D005260:Female; D007980:Levodopa / Q000494:pharmacology; D008253:Macaca mulatta; D009043:Motor Activity / Q000187:drug effects; D009570:Nitriles; D009596:Nitrophenols; D010300:Parkinson Disease / Q000188:drug therapy*; D011247:Pregnancy; D011728:Pyridones / Q000494:pharmacology*; D051381:Rats; D000077867:Tolcapone
chemical_list: D000578:Amidines; D000978:Antiparkinson Agents; D001577:Benzophenones; D065098:Catechol O-Methyltransferase Inhibitors; D002396:Catechols; D004791:Enzyme Inhibitors; D009570:Nitriles; D009596:Nitrophenols; D011728:Pyridones; C067181:N-(2-pyridone-6-yl)-N',N'-di-n-propylformamidine; D007980:Levodopa; C071192:entacapone; D000077867:Tolcapone; D002394:Catechol O-Methyltransferase