Human bronchiolar deposition and retention of 6-, 8- and 10-micrograms particles.
Three groups, each consisting of 6 healthy subjects, inhaled, respectively, 6-micrograms (aerodynamic diameter), 8-micrograms, and 10-micrograms Teflon particles, labeled with indium-111. The particles were inhaled at an extremely low flow rate, 0.05 L/s. Lung retention was measured after 0, 24, 48, and 72 h. Two models were used to calculate particle deposition in the lungs in the various generations: the Karolinska Institute model (KI model) and the University of Southampton model (US model). From the experimental clearance data and the theoretical deposition data, it was calculated that the average retention after 24 h was around 100% for particles deposited in generations 13-16 (ciliated bronchioles) and around 20% in generations 0-12 (both large and small ciliated airways). In these calculations, it was assumed that the retained fractions were independent of particle size. The depositions in the bronchial region (generations 0-8), bronchiolar region (generations 9-15 or 9-16), and the alveolar region were calculated using the two models and compared with the recent ICRP model. On the whole, the three models agreed fairly well.
Camner
P
P
Division of Inhalation Toxicology, Karolinska Institute, Stockholm, Sweden.
Anderson
M
M
Philipson
K
K
Bailey
A
A
Hashish
A
A
Jarvis
N
N
Bailey
M
M
Svartengren
M
M
D000280:Administration, Inhalation; D000328:Adult; D001980:Bronchi / Q000378:metabolism*; D005260:Female; D006801:Humans; D007205:Indium Radioisotopes / Q000008:administration & dosage / Q000493:pharmacokinetics; D008168:Lung / Q000378:metabolism*; D008297:Male; D008863:Microspheres; D009079:Mucociliary Clearance / Q000502:physiology*; D010316:Particle Size; D011138:Polytetrafluoroethylene / Q000008:administration & dosage / Q000493:pharmacokinetics*; D012129:Respiratory Function Tests
D007205:Indium Radioisotopes; D011138:Polytetrafluoroethylene