Negative finding in cross-protective activity of Japanese Borrelia isolates against infection with three species of Lyme disease Borrelia in outbred mice.
Outer surface protein A (OspA) is the most promising candidate for a component vaccine against Lyme disease caused by Borrelia burgdorferi sensu lato. Active cross-protection using a whole-cell vaccine prepared from strains belonging various OspA serotypes observed in Japan and worldwide was examined. No cross-protection was obtained by heterologous OspA-serotype vaccines. Since OspA is a highly variable protein expressed by Borrelia, this suggests that immunologically different OspA serotypes need to be combined for the development of an effective vaccine in Japan.
Masuzawa
T
T
Department of Microbiology, School of Pharmaceutical Sciences, University of Shizuoka, Japan.
Kurita
T
T
Yanagihara
Y
Y
D000818:Animals; D000942:Antigens, Bacterial / Q000276:immunology*; D000954:Antigens, Surface / Q000235:genetics / Q000276:immunology*; D001096:Arachnid Vectors / Q000382:microbiology; D001425:Bacterial Outer Membrane Proteins / Q000235:genetics / Q000276:immunology*; D001428:Bacterial Vaccines / Q000276:immunology*; D001898:Borrelia / Q000145:classification / Q000235:genetics / Q000276:immunology* / Q000302:isolation & purification; D001899:Borrelia Infections / Q000276:immunology / Q000382:microbiology / Q000517:prevention & control*; D003429:Cross Reactions; D006801:Humans; D007564:Japan; D008074:Lipoproteins; D008193:Lyme Disease / Q000382:microbiology*; D051379:Mice; D012703:Serotyping; D013045:Species Specificity; D013987:Ticks / Q000382:microbiology; D014611:Vaccination
D000942:Antigens, Bacterial; D000954:Antigens, Surface; D001425:Bacterial Outer Membrane Proteins; D001428:Bacterial Vaccines; D008074:Lipoproteins; C072045:OspA protein