T-cell transfer and cytokine/TCR gene deletion models in the study of inflammatory bowel disease.
Until recently there existed no appropriate immunological animal models for human inflammatory bowel diseases (IBD). Today a number of models, mostly in the mouse and rat, have proved useful in the study of several aspects of IBD, including the histopathology and the disease-inductive and -protective cell types, subsets and cytokines, for example CD4+ T cells, IFN gamma, IL-12, IL-2, IL-10 and TGF beta. Furthermore, these recent IBD models make it possible to examine various chemo- and immunotherapeutic approaches. This review focuses on IBD development in adoptive T-cell transfer models and in gene-deleted mice.
Bregenholt
S
S
Department of Medical Anatomy, Panum Institute, University of Copenhagen, Denmark.
Delbro
D
D
Claesson
M H
MH
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D016207:Cytokines / Q000502:physiology*; D004195:Disease Models, Animal; D019206:GTP-Binding Protein alpha Subunits, Gi-Go / Q000502:physiology; D017353:Gene Deletion; D019672:Genes, T-Cell Receptor; D018928:Immunity, Mucosal; D007116:Immunization, Passive; D015212:Inflammatory Bowel Diseases / Q000276:immunology*; D016753:Interleukin-10 / Q000502:physiology; D051379:Mice; D018345:Mice, Knockout; D016513:Mice, SCID; D051381:Rats; D013601:T-Lymphocytes / Q000276:immunology*
D016207:Cytokines; D016753:Interleukin-10; D019206:GTP-Binding Protein alpha Subunits, Gi-Go