title: Chemical structure of lipid A from Helicobacter pylori strain 206-1 lipopolysaccharide.
abstract: The chemical structure of a novel lipid A, which was obtained as a major component from lipopolysaccharide of Helicobacter pylori strain 206-1, was determined to be a glucosamine beta(1-6) disaccharide 1-(2-aminoethyl)phosphate acylated by (R)-3-hydroxyoctadecanoic acid and (R)-3-(octadecanoyloxy)octadecanoic acid at the 2- and 2'-position, respectively. The absence of a phosphoryl group at the 4'-position and fatty acyl groups at the 3- and 3'-position, and the stoichiometric presence of 2-aminoethyl phosphate at the 1-position are unique features, distinguishing it from the lipid A of enterobacteria.
authors.affiliation: Department of Chemistry, Graduate School of Science, Osaka University, Toyonaka. ysuda@chem.sci.osaka-u.ac.jp
authors.forename: Y
authors.initials: Y
authors.lastname: Suda
authors.forename: T
authors.initials: T
authors.lastname: Ogawa
authors.forename: W
authors.initials: W
authors.lastname: Kashihara
authors.forename: M
authors.initials: M
authors.lastname: Oikawa
authors.forename: T
authors.initials: T
authors.lastname: Shimoyama
authors.forename: T
authors.initials: T
authors.lastname: Hayashi
authors.forename: T
authors.initials: T
authors.lastname: Tamura
authors.forename: S
authors.initials: S
authors.lastname: Kusumoto
mesh_terms: D002240:Carbohydrate Sequence; D016480:Helicobacter pylori / Q000737:chemistry*; D008050:Lipid A / Q000737:chemistry*; D008070:Lipopolysaccharides / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008969:Molecular Sequence Data; D015394:Molecular Structure
chemical_list: D008050:Lipid A; D008070:Lipopolysaccharides