[Levels of endothelin-I in bronchoalveolar fluid of patients with selected respiratory tract diseases].
Endothelin-I (ET-I) levels in BALF of symptomatic (n = 7) and asymptomatic (n = 10) asthmatic patients, sarcoidosis (n = 10), allergic alveolitis (n = 6) and healthy volunteers (n = 6) was evaluated. In all patients BALF level of endothelin-I was assessed by radioimmunoassay. We observed that patients with symptomatic asthma had more increased amounts of ET-I in BALF in comparison with asymptomatic asthmatics, patients with sarcoidosis, allergic alveolitis and control group.


CONCLUSIONS
1. Presence of ET-I in BALF indicates that this peptide is involved in the pathogenesis of bronchial asthma, sarcoidosis and allergic alveolitis. 2. Endothelin-I is involved in bronchial smooth muscle contraction.
Gawlik
R
R
Katedry i Kliniki Chorób Wewnetrznych i Alergologii, Slaskiej Akademii Medycznej w Zabrzu.
Ziora
D
D
Rogala
E
E
Pluskiewicz
W
W
D000328:Adult; D000542:Alveolitis, Extrinsic Allergic / Q000378:metabolism; D001249:Asthma / Q000378:metabolism; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry*; D019332:Endothelin-1 / Q000737:chemistry*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012140:Respiratory Tract Diseases / Q000378:metabolism*; D017565:Sarcoidosis, Pulmonary / Q000378:metabolism
D019332:Endothelin-1