Invasive Haemophilus influenzae type b (Hib) infection in an adult patient with a selective deficiency of antibody to the Hib capsular polysaccharide.
A 31-year-old woman without any underlying disease contracted severe invasive Haemophilus influenzae type b (Hib) infection but developed no antibodies to the Hib capsular polysaccharide. Serum immunoglobulin levels were normal, but she had an isolated deficiency of antibody to Hib. Subsequently, immunization with a tetanus toxoid-conjugated Hib vaccine induced only a minimal response. However, she had a protective level of antibody (> 1 microgram/mL) after the fifth vaccination.
Follin
P
P
Department of Infectious Diseases, Faculty of Health Science, University of Linköping, Sweden.
Ulanova
M
M
Hahn-Zoric
M
M
Hanson
L A
LA
D000328:Adult; D000907:Antibodies, Bacterial / Q000276:immunology*; D005260:Female; D006192:Haemophilus Infections / Q000276:immunology* / Q000382:microbiology / Q000628:therapy; D018073:Haemophilus Vaccines / Q000276:immunology*; D019741:Haemophilus influenzae type b / Q000276:immunology*; D006801:Humans; D007136:Immunoglobulins / Q000276:immunology*; D007167:Immunotherapy
D000907:Antibodies, Bacterial; D018073:Haemophilus Vaccines; D007136:Immunoglobulins; C074704:bacterial polysaccharide immune globulin