title: Metastatic inflammatory carcinoma of the rectum: tumor spread by three routes.
abstract: We report a case of a patient with adenocarcinoma of the rectum with inflammatory metastases to the skin who was treated with radiation therapy and subsequently developed lymphatic obstruction with resultant extensive lymphedema of the lower extremities. Histopathologic examination and immunohistochemistry showed intralymphatic, intravascular, and interstitial malignant cells in the dermis. To our knowledge, this is the second reported case of inflammatory carcinoma arising from metastatic carcinoma of the rectum. However, tumor cell spread to the skin by three routes has not previously been demonstrated.
authors.affiliation: Department of Dermatology, University of Maryland School of Medicine, Baltimore 21201 U.S.A.
authors.forename: C L
authors.initials: CL
authors.lastname: Kauffman
authors.forename: B
authors.initials: B
authors.lastname: Sina
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology / Q000532:radiotherapy / Q000556:secondary*; D002196:Capillaries / Q000473:pathology; D002272:Carcinoembryonic Antigen / Q000032:analysis; D004730:Endothelium, Vascular / Q000473:pathology; D004890:Erythema / Q000473:pathology; D017809:Fatal Outcome; D006801:Humans; D007150:Immunohistochemistry; D008207:Lymphatic Metastasis / Q000473:pathology; D008208:Lymphatic System / Q000473:pathology; D008209:Lymphedema / Q000209:etiology; D008297:Male; D008875:Middle Aged; D009360:Neoplastic Cells, Circulating / Q000473:pathology; D012004:Rectal Neoplasms / Q000473:pathology* / Q000532:radiotherapy; D012867:Skin / Q000098:blood supply / Q000473:pathology; D012878:Skin Neoplasms / Q000556:secondary*
chemical_list: D002272:Carcinoembryonic Antigen