Effect of alprazolam and ketamine on seizures induced by two different convulsants.
Effect of two anticonvulsants with different mechanism of action, i.e. alprazolam and ketamine, was tested in two types of seizure activity. The first one was induced by N-(3,5-dimethoxy-4-propoxyphenylethyl)-aziridine, the second one by pentylenetetrazol. While alprazolam alleviated both the minimal as well as major paroxysms, ketamine suppressed only major seizures. These effects are discussed in terms of the both N-methyl-D-aspartate and GABA receptors involvement.
Herink
J
J
Military Medical Academy J. E. Purkynĕ, Hradec Králové.
D000525:Alprazolam / Q000627:therapeutic use*; D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use*; D001388:Aziridines; D003292:Convulsants; D007649:Ketamine / Q000627:therapeutic use*; D008297:Male; D010433:Pentylenetetrazole; D051381:Rats; D017208:Rats, Wistar; D012640:Seizures / Q000139:chemically induced / Q000188:drug therapy*
D000927:Anticonvulsants; D001388:Aziridines; D003292:Convulsants; C098190:N-((3,5-dimethoxy-4-propoxyphenyl)ethyl)aziridine; D007649:Ketamine; D010433:Pentylenetetrazole; D000525:Alprazolam