Effect of lecithinized-superoxide dismutase on the interstitial pneumonia model induced by bleomycin in mice.
Superoxide anion (O2-) acts as an exacerbation factor in interstitial pneumonia. Lecithinized-superoxide dismutase (PC-SOD), which is synthesized with a lecithin derivative bound covalently to recombinant human Cu,Zn-SOD, has a longer half-life in plasma and higher affinity to cell membranes than unmodified SOD. The effect of PC-SOD was evaluated using the bleomycin-induced interstitial pneumonia mouse model. Treatment with PC-SOD at 10 mg/kg significantly reduced the hydroxyproline content and fibrosis score. Namely, PC-SOD suppressed the progression of pulmonary fibrosis on the bleomycin-induced interstitial pneumonia mouse model. PC-SOD may be a potential drug for interstitial pneumonia therapy.
Yamazaki
C
C
Tokyo Research Institute, Seikagaku Corporation, Tokyo, Japan.
Hoshino
J
J
Hori
Y
Y
Sekiguchi
T
T
Miyauchi
S
S
Mizuno
S
S
Horie
K
K
D000818:Animals; D000964:Antimetabolites, Antineoplastic / Q000009:adverse effects*; D001761:Bleomycin / Q000009:adverse effects*; D004195:Disease Models, Animal; D005355:Fibrosis; D006909:Hydroxyproline / Q000187:drug effects / Q000378:metabolism; D008168:Lung / Q000033:anatomy & histology / Q000201:enzymology / Q000473:pathology; D017563:Lung Diseases, Interstitial / Q000139:chemically induced* / Q000188:drug therapy* / Q000201:enzymology; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010713:Phosphatidylcholines / Q000494:pharmacology; D011994:Recombinant Proteins / Q000627:therapeutic use; D013482:Superoxide Dismutase / Q000097:blood / Q000627:therapeutic use*
D000964:Antimetabolites, Antineoplastic; D010713:Phosphatidylcholines; D011994:Recombinant Proteins; D001761:Bleomycin; D013482:Superoxide Dismutase; D006909:Hydroxyproline