title: Evidence for genetic variability in venous responsiveness.
abstract: Alterations in adrenergic mediated vascular responsiveness and glucose metabolism have been implicated in the pathogenesis of essential hypertension. We sought for a human model to study possible interactions between the two pathogenetical factors. In a group of Latin-Americans there is a predominance of diabetes mellitus, impaired glucose tolerance and obesity, while the rate of hypertension is unexpectedly low (lower than in the normal population). Here we demonstrate attenuated alpha 1 adrenergic mediated vasoconstriction in the above group, suggesting a possible protective mechanism against the development hypertension.
authors.affiliation: Department of Medicine, Maricopa Medical Center, Phoenix, USA.
authors.forename: Z
authors.initials: Z
authors.lastname: Vajo
authors.forename: B
authors.initials: B
authors.lastname: Székács
authors.forename: W
authors.initials: W
authors.lastname: Dachman
mesh_terms: D000316:Adrenergic alpha-Agonists / Q000494:pharmacology; D000328:Adult; D004305:Dose-Response Relationship, Drug; D005260:Female; D005823:Genetics; D005947:Glucose / Q000378:metabolism; D006225:Hand / Q000098:blood supply; D006801:Humans; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000294:innervation*; D010656:Phenylephrine / Q000494:pharmacology; D012039:Regional Blood Flow / Q000502:physiology; D013564:Sympathetic Nervous System / Q000378:metabolism / Q000502:physiology*; D014664:Vasodilation / Q000187:drug effects; D014680:Veins / Q000294:innervation / Q000378:metabolism / Q000502:physiology
chemical_list: D000316:Adrenergic alpha-Agonists; D010656:Phenylephrine; D005947:Glucose