title: Multilamellar structures of DNA complexes with cationic liposomes.
abstract: Studies of DNA complexes with cationic liposomes are prompted by the search for nonviral DNA carriers for gene therapy. Recent experiments have identified a stable multilamellar phase in which ordered smectic layers of DNA alternate with cationic bilayers. In this paper we identify the forces governing DNA adsorption on cationic lamellae, including a membrane-induced attraction between the adsorbed DNA. Calculating the DNA interhelical spacing as a function of system composition, the model successfully explains recent surprising observations.
authors.affiliation: Department of Chemical Engineering, University of Delaware, Newark 19716, USA. dan@che.udel.edu
authors.forename: N
authors.initials: N
authors.lastname: Dan
mesh_terms: D000327:Adsorption; D001665:Binding Sites; D055592:Biophysical Phenomena; D001703:Biophysics; D002412:Cations; D004247:DNA / Q000008:administration & dosage / Q000737:chemistry*; D004337:Drug Carriers; D015316:Genetic Therapy; D066298:In Vitro Techniques; D008081:Liposomes / Q000737:chemistry*; D046911:Macromolecular Substances; D008956:Models, Chemical; D055672:Static Electricity; D013499:Surface Properties; D013816:Thermodynamics
chemical_list: D002412:Cations; D004337:Drug Carriers; D008081:Liposomes; D046911:Macromolecular Substances; D004247:DNA