Cadmium and/or selenium effects on guinea pig lung PGE2, TXB2 and LTC4.
Male Hartley guinea pigs (480-610 g; n=5) were treated intratracheally with saline, cadmium (Cd, 0.3 mg) as cadmium chloride, selenium (Se, 0.3 or 0.06 mg) as sodium selenite or Se (0.06 mg) and Cd (0.3 mg). After 24 hours, lungs were collected and analyzed for prostaglandin (PGE2), thromboxane (TXB2) and leukotriene (LTC4) levels. Results indicated that, 0.3 mg Se and 0.06 mg Se in combination with 0.3 mg Cd increased PGE2 significantly. Selenium and Cd alone or in combination, decreased LTC4 and TXB2 significantly.
Bell
R R
RR
Novartis Pharmaceutical Corp., Summit, NJ 07901-1398, USA.
Soliman
M R
MR
Nonavinakere
V K
VK
Hammerbeck
D M
DM
Early
J L
JL
D000818:Animals; D019256:Cadmium Chloride / Q000008:administration & dosage / Q000633:toxicity*; D002273:Carcinogens / Q000633:toxicity*; D015232:Dinoprostone / Q000378:metabolism*; D004357:Drug Synergism; D006168:Guinea Pigs; D017997:Leukotriene C4 / Q000378:metabolism*; D008168:Lung / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D018038:Sodium Selenite / Q000008:administration & dosage / Q000633:toxicity*; D013929:Thromboxane B2 / Q000378:metabolism*
D002273:Carcinogens; D017997:Leukotriene C4; D013929:Thromboxane B2; D018038:Sodium Selenite; D019256:Cadmium Chloride; D015232:Dinoprostone