Fluorine-18-labeled fluorine gas for synthesis of tracer molecules.
The aim of this work was to develop a method to produce 18F-labeled fluorine gas ([18F]F2) with high specific radioactivity (SA, radioactivity/mass-ratio). 18F-Labeled methyl fluoride ([18F]CH3F) was synthesized from [18F]F-aq and mixed with carrier F2 in an inert neon matrix. The constituents were atomized in an electric discharge, after which a rearrangement and 18F for 19F exchange took place. [18F]F2 with a specific radioactivity of up to 55 GBq/mumol is available for the labeling synthesis of tracers for positron emission tomography (PET).
Bergman
J
J
Turku Pet Centre, Abo Akademi University, Finland.
Solin
O
O
D002849:Chromatography, Gas; D017357:Cyclotrons; D005462:Fluorine Radioisotopes; D006845:Hydrocarbons, Fluorinated / Q000737:chemistry*; D007553:Isotope Labeling / Q000379:methods*; D007700:Kinetics; D007834:Lasers; D013054:Spectrophotometry, Atomic; D014466:Ultraviolet Rays
D005462:Fluorine Radioisotopes; D006845:Hydrocarbons, Fluorinated; C029999:fluoromethane