title: Evidence of rare codon clusters within Escherichia coli coding regions.
abstract: It is known that there is a high occurrence of rare codons at the start of coding region. Here it is shown that although the remainder of the gene is likely to contain a relatively low number of rare codons, rare and non-rare codons do not form a random sequence. It is apparent that throughout the coding region there is a higher than expected number of rare codon clusters. For example once a rare codon has occurred there is a greater chance than expected of the next six codons containing another rare codon. This non-random distribution implies that rare codons may have an as yet unidentified biological role.
authors.affiliation: Department of Applied Biology, University of Central Lancashire, Preston, UK. d.a.phoenix@uclan.ac.uk
authors.forename: D A
authors.initials: DA
authors.lastname: Phoenix
authors.forename: E
authors.initials: E
authors.lastname: Korotkov
mesh_terms: D001483:Base Sequence; D003062:Codon / Q000235:genetics*; D004269:DNA, Bacterial / Q000235:genetics; D016208:Databases, Factual; D004926:Escherichia coli / Q000235:genetics*; D005798:Genes, Bacterial; D014176:Protein Biosynthesis; D017510:Protein Folding
chemical_list: D003062:Codon; D004269:DNA, Bacterial