title: Diffusion-weighted imaging of the human optic nerve: a new approach to evaluate optic neuritis in multiple sclerosis.
abstract: The apparent diffusion coefficient (ADC) in the optic nerve was measured from diffusion-weighted magnetic resonance imaging using an intravoxel incoherent motion (IVIM) sequence. The subjects were seven normal volunteers and eight patients with multiple sclerosis (MS) with a total of four optic nerves with acute neuritis and nine nerves with chronic neuritis. The mean ADC (4.18 +/- 1.13 x 10(-3) mm2/s, n = 9) in the optic nerves with chronic neuritis was significantly higher than that in normal volunteers (1.56 +/- 0.675 x 10(-3) mm2/s, n = 14) and that in the nerves with acute neuritis (0.94 +/- 0.43 x 10(-3) mm2/s n = 4) (P < 0.001). The ADC is useful in assessing MS foci in the optic nerves.
authors.affiliation: Department of Radiology, Yokohama City University, School of Medicine, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Iwasawa
authors.forename: H
authors.initials: H
authors.lastname: Matoba
authors.forename: A
authors.initials: A
authors.lastname: Ogi
authors.forename: H
authors.initials: H
authors.lastname: Kurihara
authors.forename: K
authors.initials: K
authors.lastname: Saito
authors.forename: T
authors.initials: T
authors.lastname: Yoshida
authors.forename: S
authors.initials: S
authors.lastname: Matsubara
authors.forename: A
authors.initials: A
authors.lastname: Nozaki
mesh_terms: D000293:Adolescent; D000328:Adult; D003287:Contrast Media; D005260:Female; D019786:Gadolinium DTPA; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000150:complications / Q000175:diagnosis*; D009900:Optic Nerve / Q000473:pathology*; D009902:Optic Neuritis / Q000175:diagnosis* / Q000209:etiology
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA