Dopamine function in obsessive-compulsive disorder: growth hormone response to apomorphine stimulation.
Indirect observations suggest that the dopaminergic system may be involved in the pathophysiology of obsessive-compulsive disorder (OCD). The dopaminergic function of 15 patients with OCD and 15 age/sex-matched controls was evaluated by measuring the growth hormone (GH) responses to stimulation with the dopaminergic agonist apomorphine (APO), which increases growth hormone-releasing hormone (GHRH), GH, and somatomedine C (SMD-C) secretions. Therefore, we measured basal plasma GH and SMD-C concentrations and GH responses to GHRH stimulation to exclude that a downstream pathology of the somatotropic axis could obscure the significance of the results of the APO test. The response of prolactin (PRL) to APO inhibition were also measured. Basal plasma levels of GH, SMD-C, and PRL, GH responses to GHRH stimulation, and PRL responses to APO inhibition did not differ in the two groups of subjects. GH responses to APO stimulation were blunted in obsessive-compulsive (OC) patients. The emetic response to the same stimulation was stronger in patients than in controls. These responses suggest that in our OC patients there is a dysregulation of the dopaminergic system, which is possibly expressed in different ways in the various areas of the central nervous system.
Brambilla
F
F
Psychoneuroendocrine Center, Istituto Scientifico H. San Raffaele, Milan, Italy.
Bellodi
L
L
Perna
G
G
Arancio
C
C
Bertani
A
A
D000293:Adolescent; D000328:Adult; D001058:Apomorphine / Q000494:pharmacology* / Q000627:therapeutic use; D004298:Dopamine / Q000097:blood*; D018491:Dopamine Agonists / Q000494:pharmacology*; D005260:Female; D013007:Growth Hormone-Releasing Hormone / Q000097:blood / Q000378:metabolism*; D019382:Human Growth Hormone / Q000097:blood / Q000378:metabolism*; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009771:Obsessive-Compulsive Disorder / Q000188:drug therapy*; D011388:Prolactin / Q000097:blood / Q000378:metabolism
D018491:Dopamine Agonists; D019382:Human Growth Hormone; D007334:Insulin-Like Growth Factor I; D011388:Prolactin; D013007:Growth Hormone-Releasing Hormone; D001058:Apomorphine; D004298:Dopamine