Hepatic undifferentiated (embryonal) sarcoma arising in a mesenchymal hamartoma.
We report the case of a hepatic undifferentiated (embryonal) sarcoma (UES) arising within a mesenchymal hamartoma (MH) in a 15-year-old girl. Mapping of the tumor demonstrated a typical MH transforming gradually into a UES composed of anaplastic stromal cells. When evaluated by flow cytometry, the MH was diploid and the UES showed a prominent aneuploid peak. Karyotypic analysis of the UES showed structural alterations of chromosome 19, which have been implicated as a potential genetic marker of MH. The histogenesis of MH and UES is still debated, and reports of a relationship between them, although suggested on the basis of histomorphologic similarities, have never been convincing. The histologic, flow cytometric, and cytogenetic evidence reported herein suggests a link between these two hepatic tumors of the pediatric population.
Lauwers
G Y
GY
Department of Pathology and Laboratory Medicine, University of Florida College of Medicine, Gainesville 32610, USA.
Grant
L D
LD
Donnelly
W H
WH
Meloni
A M
AM
Foss
R M
RM
Sanberg
A A
AA
Langham
M R
MR
D000293:Adolescent; D014408:Biomarkers, Tumor / Q000032:analysis; D005260:Female; D005434:Flow Cytometry; D006222:Hamartoma / Q000737:chemistry / Q000000981:diagnostic imaging / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D007621:Karyotyping; D008113:Liver Neoplasms / Q000737:chemistry / Q000000981:diagnostic imaging / Q000473:pathology*; D008648:Mesoderm / Q000737:chemistry / Q000000981:diagnostic imaging / Q000473:pathology*; D009373:Neoplasms, Germ Cell and Embryonal / Q000737:chemistry / Q000000981:diagnostic imaging / Q000473:pathology*; D011003:Ploidies; D012509:Sarcoma / Q000737:chemistry / Q000000981:diagnostic imaging / Q000473:pathology*; D014057:Tomography, X-Ray Computed
D014408:Biomarkers, Tumor