Relative potentiality of some contragestational agents on trauma induced deciduoma formation in immature rats.
Relative progestational and antiprogestational profile of four contragestational agents, viz. RMI-12,936, RU-38,486, STS-557 and WIN-32,729, known to possess either or both the properties in other test systems, was determined in immature rats using deciduoma induction as marker. The deciduoma was produced by needle traumatization in one of the uterine horn, and the extent of stimulation was analysed, both macro and microscopically, against the control nontraumatized horn. The results indicated that the agents which demonstrated better potentiality(ies) as progestational and/or antiprogestational in this bioassay exhibit contraceptive efficacy at relatively lower doses as compared to those that showed mild to moderate potentiality.
Kitchlu
S
S
Division of Endocrinology, Central Drug Research Institute, Lucknow, India.
Mehrotra
P K
PK
D000818:Animals; D003656:Decidua / Q000187:drug effects* / Q000254:growth & development; D005260:Female; D011372:Progestins / Q000037:antagonists & inhibitors*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014599:Uterus / Q000293:injuries*
D011372:Progestins