Pharmacokinetics of tertiary butyl alcohol in male and female Fischer 344 rats.
Tertiary butyl alcohol (TBA) is a small aliphatic alcohol with multiple industrial and scientific uses. A comprehensive pharmacokinetic profile for TBA has not been determined in rats. The purpose of this study was to fully characterize the pharmacokinetics of TBA in male and female F-344 rats following intravenous administration of 37.5, 75, 150 and 300 mg/kg TBA. TBA was observed to undergo a rapid distribution phase followed by a slower elimination phase. The steady-state volume of distribution for TBA was roughly 4.5 times greater than total body water, and the clearance was lower than the estimated glomerular filtration rate. The elimination of TBA appears to saturate at higher doses, as evidenced by a disproportional increase in area under the concentration-time curve and decreased rate of clearance.
Poet
T S
TS
Chemical Industry Institute of Toxicology, Research Triangle Park, NC 27709, USA.
Valentine
J L
JL
Borghoff
S J
SJ
D000818:Animals; D005260:Female; D005919:Glomerular Filtration Rate; D008297:Male; D008657:Metabolic Clearance Rate; D051381:Rats; D011916:Rats, Inbred F344; D020002:tert-Butyl Alcohol / Q000493:pharmacokinetics*
D020002:tert-Butyl Alcohol