Interaction of muscle relaxant effect of gallamine with ethanol: in vivo mammalian model.
Ethanol produces alterations in muscular contraction and neuromuscular function both in vitro and in vivo in mammalian and amphibian tissues in dose dependent manner. It is not very well known whether gallamine, a commonly used muscle relaxant produces any interaction with ethanol. Hence in the present study, interactions of ethanol with gallamine are undertaken using rabbit head drop method. The latency time to produce head drop by gallamine in the absence and presence of ethanol (dose which produce ataxia) was insignificantly different (P > 0.05). It may be due to fact that ataxic dose may not be affecting neuromuscular transmission a significant manner. It, therefore, does not warrant to adjust the dose of gallamine in alcoholic persons.
Kela
A K
AK
Department of Pharmacology, Lady Hardinge Medical College, New Delhi, India.
Sharma
A K
AK
Mehta
S C
SC
Mehta
V L
VL
D000818:Animals; D004347:Drug Interactions; D000431:Ethanol / Q000494:pharmacology*; D005260:Female; D005703:Gallamine Triethiodide / Q000494:pharmacology*; D008297:Male; D003473:Neuromuscular Nondepolarizing Agents / Q000494:pharmacology*; D011817:Rabbits
D003473:Neuromuscular Nondepolarizing Agents; D000431:Ethanol; D005703:Gallamine Triethiodide