title: Inflammatory myofibroblastic tumor of bone: report of two cases with evidence of clonal chromosomal changes.
abstract: Inflammatory myofibroblastic tumor (inflammatory pseudotumor) is a pseudosarcomatous lesion that is recognized with increasing frequency in various anatomic locations. However, this lesion has not been previously reported in bone. We report on two cases of inflammatory myofibroblastic tumor occurring in bone in young adults. Both tumors presented as slightly painful, osteolytic, and well-delineated lesions of the distal femur, with a hyperintense signal on T2-weighted magnetic resonance imaging. The patients had an uneventful recovery after curettage. The follow-up time was 11 months for both patients, and no recurrence was noted. On histologic examination, the lesions were characterized by collagen-rich and generally poorly cellular tissue containing spindled to plump (myo)fibroblast-like cells and a variable admixture of inflammatory cells. Focal calcifications and reactive bone formation were present. Clonal, albeit different, chromosomal changes were found in both cases (47,XY,-9,-12,add(21)(q21),+der(?)t(?;9)(?;q11), +mar,+r and 47, XY, +r/47, idem, add(12)(p13)). The present and other reported cytogenetic findings suggest that inflammatory myofibroblastic tumors could well be neoplastic.
authors.affiliation: Department of Pathology, University Hospitals Leuven, Belgium.
authors.forename: R
authors.initials: R
authors.lastname: Sciot
authors.forename: P
authors.initials: P
authors.lastname: Dal Cin
authors.forename: C D
authors.initials: CD
authors.lastname: Fletcher
authors.forename: J M
authors.initials: JM
authors.lastname: Hernandez
authors.forename: J L
authors.initials: JL
authors.lastname: Garcia
authors.forename: I
authors.initials: I
authors.lastname: Samson
authors.forename: L
authors.initials: L
authors.lastname: Ramos
authors.forename: P
authors.initials: P
authors.lastname: Brys
authors.forename: B
authors.initials: B
authors.lastname: Van Damme
authors.forename: H
authors.initials: H
authors.lastname: Van den Berghe
mesh_terms: D000328:Adult; D001847:Bone Diseases / Q000000981:diagnostic imaging / Q000235:genetics / Q000473:pathology*; D002869:Chromosome Aberrations; D025063:Chromosome Disorders; D002881:Chromosomes, Human, Pair 12; D002891:Chromosomes, Human, Pair 21; D002893:Chromosomes, Human, Pair 3; D002899:Chromosomes, Human, Pair 9; D005819:Genetic Markers; D006104:Granuloma, Plasma Cell / Q000000981:diagnostic imaging / Q000235:genetics / Q000473:pathology*; D006801:Humans; D017403:In Situ Hybridization; D007719:Knee Joint / Q000000981:diagnostic imaging / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D014057:Tomography, X-Ray Computed
chemical_list: D005819:Genetic Markers