title: Bromovinyldeoxyurdine treatment of outer retinal necrosis due to varicella-zoster virus: a case-report.
abstract: In December 1995, a 70-years old male was referred to us because of rapid visual loss in the right eye, one month after a central retinal artery occlusion in the left eye. This renal transplant patient, with limited renal function, was on immunosuppressive therapy. The diagnosis of bilateral progressive outer retinal necrosis (PORN) due to varicella-zoster virus (VZV) was confirmed by polymerase chain reaction (PCR) detection of VZV DNA in the aqueous fluid. As retinitis progressed despite of intravenous acyclovir administration, the antiviral therapy was switched to oral bromovinyldeoxyuridine (BVDU). This case-report demonstrates that oral BVDU can be a good alternative to acyclovir for the treatment of VZV retinal infections.
authors.affiliation: Department of Ophthalmology, U.Z. Leuven.
authors.forename: H
authors.initials: H
authors.lastname: Dullaert
authors.forename: P C
authors.initials: PC
authors.lastname: Maudgal
authors.forename: A
authors.initials: A
authors.lastname: Leys
authors.forename: L
authors.initials: L
authors.lastname: Dralands
authors.forename: E
authors.initials: E
authors.lastname: Clercq
mesh_terms: D000284:Administration, Oral; D000368:Aged; D000998:Antiviral Agents / Q000627:therapeutic use*; D001973:Bromodeoxyuridine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005451:Fluorescein Angiography; D006562:Herpes Zoster / Q000150:complications*; D006801:Humans; D016867:Immunocompromised Host; D016030:Kidney Transplantation / Q000276:immunology; D008297:Male; D015882:Retinal Necrosis Syndrome, Acute / Q000175:diagnosis / Q000188:drug therapy* / Q000821:virology*
chemical_list: D000998:Antiviral Agents; C020235:brivudine; D001973:Bromodeoxyuridine