PTHrP(107-111) inhibits in vivo resorption that was stimulated by PTHrP(1-34) when applied intermittently to neonatal mice.
Stimulated resorption by PTH(1-34) and PTHrP(1-34) was studied in a neonatal mouse model by injecting a relatively high dose (0.2 microgram/g BW) of the peptides for 6 or 16 consecutive daily injections. 3H-Tetracycline was applied once, before the beginning of the injection period. Only PTHrP(1-34) increased resorption as revealed by decreased radioactivity remaining in the tibia when compared with vehicle-treated mice. This activity was related to increased numbers of mature osteoclasts in the metaphysis of the young bones. PTHrP(107-111) completely aborted the stimulated resorption when applied simultaneously with PTHrP(1-34).
Rihani-Basharat
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S
Division of Morphological Sciences, Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
Lewinson
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D
D000135:Acid Phosphatase / Q000032:analysis; D000818:Animals; D000831:Animals, Newborn; D001862:Bone Resorption / Q000139:chemically induced / Q000188:drug therapy*; D007527:Isoenzymes / Q000032:analysis; D051379:Mice; D010010:Osteoclasts / Q000187:drug effects*; D010281:Parathyroid Hormone / Q000008:administration & dosage / Q000627:therapeutic use*; D044162:Parathyroid Hormone-Related Protein; D010446:Peptide Fragments / Q000008:administration & dosage*; D011506:Proteins / Q000008:administration & dosage* / Q000627:therapeutic use*; D000071681:Tartrate-Resistant Acid Phosphatase; D013752:Tetracycline / Q000032:analysis; D013977:Tibia / Q000166:cytology / Q000187:drug effects; D014316:Tritium
D007527:Isoenzymes; D010281:Parathyroid Hormone; D044162:Parathyroid Hormone-Related Protein; D010446:Peptide Fragments; D011506:Proteins; C071784:parathyroid hormone-related protein (107-111); D014316:Tritium; C054296:parathyroid hormone-related protein (1-34); D000135:Acid Phosphatase; D000071681:Tartrate-Resistant Acid Phosphatase; D013752:Tetracycline