[Effect on 5'-deoxy-5-fluorouridine (5'-DFUR) of pyrimidine nucleoside phosphorylase (PyNPase), matrix metalloprotease and serum IAP values. Hokuriku Colorectal Cancer Chemotherapy Study Group].
PyNPase activity, MMPs activity and serum IAP values were measured in tumor tissues from colorectal cancer patients who had been divided into two groups, one given preoperative 5'-DFUR and the controls. PyNPase activity of the preoperative administration group was approximately equivalent to that of the controls. In the control group, correlations were assessed between PyNPase activity and activities of MMP1 and MMP3. To assess the effect of 5'-DFUR on the activity of MMPs, we divided patients into two groups, a high and a low PyNPase activity group. Although there was no correlation with MMPs activity of the preoperative administration group and the control group in the low PyNPase activity group, the activities of MMP1 and MMP9 of the control group were significantly higher in the high PyNPase activity group. Moreover, the serum IAP value of the administration group was significantly lower than that of the control group. These results indicated that PyNPase activity was thus suggested to be somehow related to MMPs activity and serum IAP values.
Nishimura
G
G
Second Dept. of Surgery, Kanazawa University, School of Medicine.
Izumi
R
R
Matsuki
N
N
Takeyama
S
S
Konishi
K
K
Fujita
H
H
Miyata
R
R
Sasaki
T
T
Kojima
Y
Y
Takada
M
M
Takita
Y
Y
Kanno
M
M
Ueno
K
K
Mura
T
T
Asano
K
K
Syouji
M
M
Yamazaki
H
H
Ooto
T
T
Ueda
H
H
Takigawa
Y
Y
Sawa
T
T
Miyazaki
I
I
D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000494:pharmacology*; D003110:Colonic Neoplasms / Q000188:drug therapy / Q000201:enzymology / Q000378:metabolism* / Q000473:pathology; D005109:Extracellular Matrix / Q000201:enzymology*; D005260:Female; D005467:Floxuridine / Q000494:pharmacology*; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008666:Metalloendopeptidases / Q000378:metabolism*; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009363:Neoplasm Proteins / Q000097:blood*; D010430:Pentosyltransferases / Q000378:metabolism*; D057845:Pyrimidine Phosphorylases; D012004:Rectal Neoplasms / Q000188:drug therapy / Q000201:enzymology / Q000378:metabolism* / Q000473:pathology
D000970:Antineoplastic Agents; D009363:Neoplasm Proteins; C030193:immunosuppressive acidic protein; D005467:Floxuridine; D010430:Pentosyltransferases; D057845:Pyrimidine Phosphorylases; D008666:Metalloendopeptidases; C025034:doxifluridine