title: Thrombocytopathia and light-chain proteinuria in a dog naturally infected with Ehrlichia canis.
abstract: A 6-year-old dog was presented for evaluation of recurrent epistaxis. Platelet counts, biochemical tests, and coagulation tests were within the normal range, but a mucosal bleeding time was prolonged; there was hyperproteinemia and a monoclonal gammopathy. Heterogeneity of light chains appeared in urine, however, thus suggesting that the gammopathy was polyclonal. Platelet aggregation tests showed decreased responsiveness to collagen. An Ehrlichia canis indirect fluorescent-antibody titer was positive (1:40). Treatment with tetracycline, melphalan, and prednisone resulted in a rapid clinical improvement that persisted for at least 3 years.
authors.affiliation: Centre Mèdic Veterinari de Barcelona, Spain.
authors.forename: F
authors.initials: F
authors.lastname: Varela
authors.forename: X
authors.initials: X
authors.lastname: Font
authors.forename: J E
authors.initials: JE
authors.lastname: Valladares
authors.forename: J
authors.initials: J
authors.lastname: Alberola
mesh_terms: D000818:Animals; D018906:Antineoplastic Agents, Alkylating / Q000627:therapeutic use; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use; D001777:Blood Coagulation / Q000502:physiology; D001791:Blood Platelet Disorders / Q000150:complications / Q000175:diagnosis / Q000662:veterinary*; D003094:Collagen / Q000494:pharmacology; D004283:Dog Diseases / Q000175:diagnosis* / Q000382:microbiology* / Q000628:therapy; D004285:Dogs; D004536:Ehrlichia / Q000302:isolation & purification*; D016873:Ehrlichiosis / Q000150:complications / Q000175:diagnosis / Q000662:veterinary*; D007147:Immunoglobulin Light Chains / Q000652:urine*; D008297:Male; D008558:Melphalan / Q000627:therapeutic use; D010265:Paraproteinemias / Q000097:blood / Q000175:diagnosis / Q000662:veterinary; D010974:Platelet Aggregation; D010976:Platelet Count; D011241:Prednisone / Q000627:therapeutic use; D011507:Proteinuria / Q000150:complications / Q000175:diagnosis / Q000662:veterinary*; D013752:Tetracycline / Q000627:therapeutic use
chemical_list: D018906:Antineoplastic Agents, Alkylating; D018931:Antineoplastic Agents, Hormonal; D007147:Immunoglobulin Light Chains; D003094:Collagen; D013752:Tetracycline; D008558:Melphalan; D011241:Prednisone