title: Tau-like proteins in the nervous system of goldfish.
abstract: This report describes the presence of a group of tau-like proteins (TLPs) in goldfish central nervous system. The TLPs were immunoreactive with antibodies that recognized the carboxy-terminal domain of mammalian tau, but not with antibodies that recognized the amino-terminus. The TLPs of goldfish exhibited the basic properties of tau proteins including neuronal specificity, structural heterogeneity, heat stability and the ability to co-assemble with tubulin. We propose that TLPs may represent a precursor of tau, that share the microtubule binding domain and the carboxy-terminal domain with mammalian tau proteins. In contrast the amino-terminus of the TLPs is much shorter and may represent a more variable domain of tau proteins.
authors.affiliation: Department of Neurobiology and Anatomy, Allegheny University of the Health Sciences, Medical College of Pennsylvania, Philadelphia, USA.
authors.forename: Y
authors.initials: Y
authors.lastname: Liu
authors.forename: J
authors.initials: J
authors.lastname: Xia
authors.forename: D
authors.initials: D
authors.lastname: Ma
authors.forename: D S
authors.initials: DS
authors.lastname: Faber
authors.forename: I
authors.initials: I
authors.lastname: Fischer
mesh_terms: D000818:Animals; D002490:Central Nervous System / Q000737:chemistry* / Q000378:metabolism; D006054:Goldfish; D006358:Hot Temperature; D008870:Microtubules / Q000378:metabolism; D009928:Organ Specificity; D011485:Protein Binding; D051381:Rats; D016875:tau Proteins / Q000096:biosynthesis / Q000737:chemistry* / Q000378:metabolism
chemical_list: D016875:tau Proteins