Altered tumor growth factor beta mRNA expression is associated with thymectomy-related clinical remission in myasthenia gravis.
Clinical remission in myasthenia gravis after thymectomy and immune suppressive treatment may be reflected by changes of immunoregulatory cytokines. Mononuclear cells from paired blood samples from fifteen patients with myasthenia gravis before and after thymectomy and immunosuppressive therapy were examined by in situ hybridization for acetylcholine receptor-induced mRNA expression of the T helper type 1 proinflammatory cytokines interferon gamma (IFN-gamma), tumor necrosis factor alpha (TNF-alpha) and TNF-beta, the T helper type 2 cytokines interleukin 4 (IL-4) and IL-10 and the immune response downregulating cytokine tumor growth factor beta (TGF-beta). A significant change was observed for TGF-beta, with increased expression after treatment and induction of clinical remission. Augmentation of TGF-beta may play a role in the induction of remission in myasthenia gravis.
Weissert
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Department of Neurology, University of Tübingen, Germany. robert.weissert@cmm.ki.se
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D000293:Adolescent; D000328:Adult; D000368:Aged; D016207:Cytokines / Q000235:genetics; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009157:Myasthenia Gravis / Q000378:metabolism* / Q000601:surgery; D012333:RNA, Messenger / Q000096:biosynthesis*; D012074:Remission Induction / Q000379:methods; D013934:Thymectomy; D016212:Transforming Growth Factor beta / Q000235:genetics*
D016207:Cytokines; D007166:Immunosuppressive Agents; D012333:RNA, Messenger; D016212:Transforming Growth Factor beta