[Value of K+ and Mg2+ in treatment of acute myocardial infarct].
A critical role analysis of literature concerning the effects of intravenous magnesium on arrhythmias and mortality in acute myocardial infarction shows discrepant results and often inappropriate methods. So far neither an antiarrhythmic efficacy nor prophylactic effects with respect to mortality could be demonstrated. In contrast, potassium substitution should be performed in the setting of acute myocardial infarction with documented hypokalemia (K+ < 3.5 mmol/l) because of increased risk of ventricular arrhythmias. According to the documented results of the trials reviewed in this article no recommendations for the routine use of magnesium in myocardial infarction can be given.
Kunert
M
M
Herzzentrum Wuppertal, Universität Witten/Herdecke.
Scheuble
L
L
Stolzenburg
H
H
Gülker
H
H
D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage*; D005117:Cardiac Complexes, Premature / Q000188:drug therapy; D004359:Drug Therapy, Combination; D006801:Humans; D007008:Hypokalemia / Q000188:drug therapy; D007262:Infusions, Intravenous; D008274:Magnesium / Q000008:administration & dosage*; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000401:mortality; D011188:Potassium / Q000008:administration & dosage*; D015996:Survival Rate; D017180:Tachycardia, Ventricular / Q000188:drug therapy / Q000401:mortality; D016896:Treatment Outcome; D014693:Ventricular Fibrillation / Q000188:drug therapy / Q000401:mortality
D000889:Anti-Arrhythmia Agents; D008274:Magnesium; D011188:Potassium