Tumor necrosis factor locus polymorphisms in rheumatoid arthritis.
We examined six polymorphic elements in the tumor necrosis factor (TNF) locus and determined their allelic distribution in 98 Caucasian rheumatoid arthritis patients in comparison with 91 ethnically-matched controls. Polymorphic elements at four biallelic sites were distributed similarly between patients and controls, irrespective of the presence or absence of DR4. Differences were observed between the two groups at the TNFa and TNFe loci, but these were consistent with extended MHC haplotypes known to be present in rheumatoid arthritis patients. Therefore, this study suggests that there is little, if any, independent contribution of the TNF locus to the genetic background for rheumatoid arthritis susceptibility.
Field
M
M
Centre for Rheumatic Diseases, University of Glasgow, Department of Medicine, Scotland, United Kingdom.
Gallagher
G
G
Eskdale
J
J
McGarry
F
F
Richards
S D
SD
Munro
R
R
Oh
H H
HH
Campbell
C
C
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D001172:Arthritis, Rheumatoid / Q000235:genetics*; D002874:Chromosome Mapping; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D011110:Polymorphism, Genetic; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*; D044465:White People / Q000235:genetics
D014409:Tumor Necrosis Factor-alpha