Quantitative trait loci analysis affecting contextual conditioning in mice.
In an extensive backcross of mice between C3H/HeJ (C3H) and C57BL/6J (B6), we sought to map genes that influence learning and memory as measured by performance in a contextual fear-conditioning paradigm. Our results indicate that there are several genetic regions that have a strong influence on performance in this paradigm. The strongest influences map to the proximal and distal ends of chromosome 1 (lod scores of 5.14 and 4.76, respectively). Other chromosomal regions (chromosomes 3, 7, 8, 9 and 18) were also identified as candidates for regions containing genes influencing contextual fear conditioning, with lod scores ranging from 1.8 to 2.7.
Caldarone
B
B
Department of Psychology, University at Albany, State University of New York 12222, USA.
Saavedra
C
C
Tartaglia
K
K
Wehner
J M
JM
Dudek
B C
BC
Flaherty
L
L
D000818:Animals; D001522:Behavior, Animal / Q000502:physiology*; D002874:Chromosome Mapping / Q000379:methods*; D002875:Chromosomes; D003213:Conditioning, Psychological / Q000502:physiology*; D005239:Fear / Q000502:physiology; D005260:Female; D005819:Genetic Markers; D008126:Lod Score; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D008815:Mice, Inbred Strains; D019655:Quantitative Trait, Heritable
D005819:Genetic Markers