title: [Hormone inactive neuroendocrine tumors of the pancreas].
abstract: During the past 10 years (1987-1996), 842 laparotomies were performed for pancreatic or periampullary neoplasms; in 25 patients (2.9%) a neuroendocrine tumor was diagnosed. In 19 of these 25 patients (76%) a non-functioning endocrine tumor and in 6 patients (24%) a hormone-active tumor (four insulinoma, one gastrinoma, one VIPoma) was found. Of 19 non-functioning neuroendocrine tumors, 14 were malignant. The resection rate of these malignant tumors was 78.6% (11 of 14; 3 resections were palliative); in comparison, the resection rate of ductal pancreatic carcinoma in our hospital was 28.1%. The probability of 5-year survival amounts to 73% after surgical resection in malignant endocrine tumors and to 19% in ductal pancreatic carcinoma (including palliative resections). As it is not always clear whether non-functioning endocrine tumors are benign or malignant, oncological resection is recommended. Adjuvant chemotherapy seems not to be necessary.
authors.affiliation: Chirurgische Universitätsklinik, Klinikum Mannheim, Fakultät für Klinische Medizin, Ruprecht-Karls-Universität Heidelberg.
authors.forename: M
authors.initials: M
authors.lastname: Schwab
authors.forename: M R
authors.initials: MR
authors.lastname: Knoll
authors.forename: D
authors.initials: D
authors.lastname: Jentschura
authors.forename: E
authors.initials: E
authors.lastname: Hagmüller
mesh_terms: D000328:Adult; D000368:Aged; D014670:Ampulla of Vater / Q000473:pathology / Q000601:surgery*; D018270:Carcinoma, Ductal, Breast / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D003138:Common Bile Duct Neoplasms / Q000175:diagnosis / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D005260:Female; D015408:Gastrinoma / Q000175:diagnosis / Q000401:mortality / Q000473:pathology / Q000601:surgery; D006801:Humans; D007340:Insulinoma / Q000175:diagnosis / Q000401:mortality / Q000473:pathology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D018358:Neuroendocrine Tumors / Q000175:diagnosis / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D010166:Palliative Care; D010179:Pancreas / Q000473:pathology; D010180:Pancreatectomy; D010190:Pancreatic Neoplasms / Q000175:diagnosis / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D011379:Prognosis; D015996:Survival Rate; D003969:Vipoma / Q000175:diagnosis / Q000401:mortality / Q000473:pathology / Q000601:surgery