CD26 as a positive regulator of HIV envelope-glycoprotein induced apoptosis in CD4+ T cells.
The membrane-expressed HIV-1 envelope glycoprotein complex, gp120/gp41, has been shown to be responsible for the initiation of cell killing by apoptosis in CD4+ T cells. By using two experimental approaches we demonstrate that CD26, independent of its DPP IV activity, appears to be implicated in this function of the gp120/gp41 complex to initiate apoptosis.
Jacotot
E
E
Unité de Virologie et Immunologie Cellulaire, UA CNRS 1157 Institut Pasteur, Paris, France.
Callebaut
C
C
Blanco
J
J
Rivière
Y
Y
Krust
B
B
Hovanessian
A G
AG
D000818:Animals; D017209:Apoptosis; D015496:CD4-Positive T-Lymphocytes / Q000473:pathology / Q000502:physiology* / Q000821:virology; D018819:Dipeptidyl Peptidase 4 / Q000502:physiology*; D015699:HIV Envelope Protein gp120 / Q000502:physiology*; D015658:HIV Infections; D015497:HIV-1; D006801:Humans
D015699:HIV Envelope Protein gp120; D018819:Dipeptidyl Peptidase 4