title: Central serotonin activity and aggression: inverse relationship with prolactin response to d-fenfluramine, but not CSF 5-HIAA concentration, in human subjects.
abstract: OBJECTIVE
  This study compared the nature and magnitude of the relationship between aggression and CSF 5-hydroxyindoleacetic acid (5-HIAA) concentration with that between aggression and the prolactin response to d-fenfluramine challenge in human subjects.
  
  
  METHODS
  The Life History of Aggression assessment scores of 24 subjects with personality disorders were compared with their lumbar CSF 5-HIAA concentrations and with their prolactin responses to d-fenfluramine challenge.
  
  
  RESULTS
  Aggression was significantly and inversely correlated with prolactin responses to d-fenfluramine challenge but not with lumbar CSF 5-HIAA concentrations in these subjects.
  
  
  CONCLUSIONS
  Prolactin response to d-fenfluramine may be more sensitive than lumbar CSF 5-HIAA concentration in detecting a relationship between aggression and central serotonin activity in noncriminally violent human subjects.
authors.affiliation: Department of Psychiatry, MCP Hahnemann School of Medicine, Allegheny University of the Health Sciences, Philadelphia, PA, USA.
authors.forename: E F
authors.initials: EF
authors.lastname: Coccaro
authors.forename: R J
authors.initials: RJ
authors.lastname: Kavoussi
authors.forename: T B
authors.initials: TB
authors.lastname: Cooper
authors.forename: R L
authors.initials: RL
authors.lastname: Hauger
mesh_terms: D000328:Adult; D000374:Aggression / Q000502:physiology*; D001921:Brain / Q000187:drug effects / Q000502:physiology; D005260:Female; D005277:Fenfluramine / Q000494:pharmacology*; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000134:cerebrospinal fluid*; D008297:Male; D010554:Personality Disorders / Q000097:blood / Q000134:cerebrospinal fluid / Q000175:diagnosis*; D011388:Prolactin / Q000097:blood*; D011569:Psychiatric Status Rating Scales; D012701:Serotonin / Q000502:physiology*; D014754:Violence
chemical_list: D005277:Fenfluramine; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D011388:Prolactin