title: Application of human liver microsomes in metabolism-based drug-drug interactions: in vitro-in vivo correlations and the Abbott Laboratories experience.
authors.affiliation: Drug Metabolism Department, Abbott Laboratories, Abbott Park, Illinois 60064-3500, USA.
authors.forename: A D
authors.initials: AD
authors.lastname: Rodrigues
authors.forename: S L
authors.initials: SL
authors.lastname: Wong
mesh_terms: D000818:Animals; D017291:Clarithromycin / Q000493:pharmacokinetics; D065607:Cytochrome P-450 Enzyme Inhibitors; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D003891:Desipramine / Q000493:pharmacokinetics; D004353:Drug Evaluation, Preclinical / Q000379:methods; D004347:Drug Interactions; D006801:Humans; D007527:Isoenzymes / Q000037:antagonists & inhibitors / Q000378:metabolism; D008862:Microsomes, Liver / Q000378:metabolism*; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D019438:Ritonavir / Q000494:pharmacology; D016593:Terfenadine / Q000378:metabolism
chemical_list: D065607:Cytochrome P-450 Enzyme Inhibitors; D007527:Isoenzymes; D004364:Pharmaceutical Preparations; D016593:Terfenadine; D003577:Cytochrome P-450 Enzyme System; D017291:Clarithromycin; D019438:Ritonavir; D003891:Desipramine