title: An intracellular protein that binds amyloid-beta peptide and mediates neurotoxicity in Alzheimer's disease.
abstract: Amyloid-beta is a neurotoxic peptide which is implicated in the pathogenesis of Alzheimer's disease. It binds an intracellular polypeptide known as ERAB, thought to be a hydroxysteroid dehydrogenase enzyme, which is expressed in normal tissues, but is overexpressed in neurons affected in Alzheimer's disease. ERAB immunoprecipitates with amyloid-beta, and when cell cultures are exposed to amyloid-beta, ERAB inside the cell is rapidly redistributed to the plasma membrane. The toxic effect of amyloid-beta on these cells is prevented by blocking ERAB and is enhanced by overexpression of ERAB. By interacting with intracellular amyloid-beta, ERAB may therefore contribute to the neuronal dysfunction associated with Alzheimer's disease.
authors.affiliation: Department of Pathology, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA. sdy1@columbia.edu
authors.forename: S D
authors.initials: SD
authors.lastname: Yan
authors.forename: J
authors.initials: J
authors.lastname: Fu
authors.forename: C
authors.initials: C
authors.lastname: Soto
authors.forename: X
authors.initials: X
authors.lastname: Chen
authors.forename: H
authors.initials: H
authors.lastname: Zhu
authors.forename: F
authors.initials: F
authors.lastname: Al-Mohanna
authors.forename: K
authors.initials: K
authors.lastname: Collison
authors.forename: A
authors.initials: A
authors.lastname: Zhu
authors.forename: E
authors.initials: E
authors.lastname: Stern
authors.forename: T
authors.initials: T
authors.lastname: Saido
authors.forename: M
authors.initials: M
authors.lastname: Tohyama
authors.forename: S
authors.initials: S
authors.lastname: Ogawa
authors.forename: A
authors.initials: A
authors.lastname: Roher
authors.forename: D
authors.initials: D
authors.lastname: Stern
mesh_terms: D015094:3-Hydroxyacyl CoA Dehydrogenases; D000544:Alzheimer Disease / Q000378:metabolism* / Q000473:pathology; D000595:Amino Acid Sequence; D016229:Amyloid beta-Peptides / Q000378:metabolism* / Q000633:toxicity; D000818:Animals; D001921:Brain / Q000378:metabolism / Q000473:pathology; D019556:COS Cells; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism*; D003001:Cloning, Molecular; D006367:HeLa Cells; D006801:Humans; D006913:Hydroxysteroid Dehydrogenases / Q000235:genetics / Q000378:metabolism; D008969:Molecular Sequence Data; D011485:Protein Binding; D011993:Recombinant Fusion Proteins / Q000235:genetics / Q000378:metabolism; D014162:Transfection
chemical_list: D016229:Amyloid beta-Peptides; D002352:Carrier Proteins; D011993:Recombinant Fusion Proteins; D006913:Hydroxysteroid Dehydrogenases; D015094:3-Hydroxyacyl CoA Dehydrogenases; C108634:HSD17B10 protein, human; C458480:Hsd17b10 protein, mouse