title: Plasmodium falciparum- and merozoite surface protein 1-specific antibody isotype balance in immune Senegalese adults.
abstract: This study shows markedly different isotype distributions of antibodies to asexual blood stages of Plasmodium falciparum and to merozoite surface protein 1 in clinically immune Senegalese adults depending on the study site. The relationships between immunoglobulin M (IgM) and IgG and between IgG3 and IgG1 antibodies differed in settings where transmission is perennial compared to settings where it is seasonal. This suggests a role for antibody class and/or subclass production and utilization in the regulation of protective immunity to such antigens.
authors.affiliation: Laboratoire d'Immunologie, Institut Pasteur, Dakar, Sénégal.
authors.forename: C M
authors.initials: CM
authors.lastname: Nguer
authors.forename: T O
authors.initials: TO
authors.lastname: Diallo
authors.forename: A
authors.initials: A
authors.lastname: Diouf
authors.forename: A
authors.initials: A
authors.lastname: Tall
authors.forename: A
authors.initials: A
authors.lastname: Dieye
authors.forename: R
authors.initials: R
authors.lastname: Perraut
authors.forename: O
authors.initials: O
authors.lastname: Garraud
mesh_terms: D000328:Adult; D000818:Animals; D000913:Antibodies, Protozoan / Q000097:blood*; D000953:Antigens, Protozoan / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000145:classification; D007132:Immunoglobulin Isotypes / Q000097:blood*; D020066:Merozoite Surface Protein 1; D010963:Plasmodium falciparum / Q000276:immunology*; D011498:Protein Precursors / Q000276:immunology*; D015800:Protozoan Proteins / Q000276:immunology*
chemical_list: D000913:Antibodies, Protozoan; D000953:Antigens, Protozoan; D007074:Immunoglobulin G; D007132:Immunoglobulin Isotypes; D020066:Merozoite Surface Protein 1; D011498:Protein Precursors; D015800:Protozoan Proteins