Tau-like proteins in the nervous system of goldfish.
This report describes the presence of a group of tau-like proteins (TLPs) in goldfish central nervous system. The TLPs were immunoreactive with antibodies that recognized the carboxy-terminal domain of mammalian tau, but not with antibodies that recognized the amino-terminus. The TLPs of goldfish exhibited the basic properties of tau proteins including neuronal specificity, structural heterogeneity, heat stability and the ability to co-assemble with tubulin. We propose that TLPs may represent a precursor of tau, that share the microtubule binding domain and the carboxy-terminal domain with mammalian tau proteins. In contrast the amino-terminus of the TLPs is much shorter and may represent a more variable domain of tau proteins.
Liu
Y
Y
Department of Neurobiology and Anatomy, Allegheny University of the Health Sciences, Medical College of Pennsylvania, Philadelphia, USA.
Xia
J
J
Ma
D
D
Faber
D S
DS
Fischer
I
I
D000818:Animals; D002490:Central Nervous System / Q000737:chemistry* / Q000378:metabolism; D006054:Goldfish; D006358:Hot Temperature; D008870:Microtubules / Q000378:metabolism; D009928:Organ Specificity; D011485:Protein Binding; D051381:Rats; D016875:tau Proteins / Q000096:biosynthesis / Q000737:chemistry* / Q000378:metabolism
D016875:tau Proteins