title: Pustular allergic contact dermatitis to isoconazole nitrate.
abstract: The topical imidazole antimycotics are widely used and are an infrequent cause of contact allergy. We report on a woman, who developed an unusual clinical picture of allergic contact dermatitis, namely papulo-pustular reaction, evoked by an isoconazole nitrate-containing cream. The histopathologic changes included subcorneal pustules, spongiosis, and an inflammatory infiltrate composed mainly of lymphocytes and some eosinophils and neutrophils. The patient demonstrated a severe vesicular reaction to isoconzole nitrate as is and at an imidazoles concentration of 0.5%. No cross-reactivity with other imidazole antimycotics was noted.
authors.affiliation: Dermatological Clinic, Meir General Hospital, 44281 Kfar Saba, Israel.
authors.forename: A
authors.initials: A
authors.lastname: Lazarov
authors.forename: A
authors.initials: A
authors.lastname: Ingber
mesh_terms: D000287:Administration, Topical; D000935:Antifungal Agents / Q000008:administration & dosage / Q000009:adverse effects*; D017449:Dermatitis, Allergic Contact / Q000209:etiology*; D003875:Drug Eruptions / Q000209:etiology*; D005260:Female; D006801:Humans; D008825:Miconazole / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D008875:Middle Aged; D009824:Ointments; D014008:Tinea Pedis / Q000188:drug therapy
chemical_list: D000935:Antifungal Agents; D009824:Ointments; D008825:Miconazole; C020382:isoconazole