title: C-terminal modifications of histidyl-N-benzylglycinamides to give improved inhibition of Ras farnesyltransferase, cellular activity, and anticancer activity in mice.
authors.affiliation: Parke-Davis Pharmaceutical Research, Division of Warner-Lambert Company, Ann Arbor, Michigan 48105, USA. mcnamad@aa.wl.com
authors.forename: D J
authors.initials: DJ
authors.lastname: McNamara
authors.forename: E
authors.initials: E
authors.lastname: Dobrusin
authors.forename: D M
authors.initials: DM
authors.lastname: Leonard
authors.forename: K R
authors.initials: KR
authors.lastname: Shuler
authors.forename: J S
authors.initials: JS
authors.lastname: Kaltenbronn
authors.forename: J
authors.initials: J
authors.lastname: Quin
authors.forename: S
authors.initials: S
authors.lastname: Bur
authors.forename: C E
authors.initials: CE
authors.lastname: Thomas
authors.forename: A M
authors.initials: AM
authors.lastname: Doherty
authors.forename: J D
authors.initials: JD
authors.lastname: Scholten
authors.forename: K K
authors.initials: KK
authors.lastname: Zimmerman
authors.forename: B S
authors.initials: BS
authors.lastname: Gibbs
authors.forename: R C
authors.initials: RC
authors.lastname: Gowan
authors.forename: M P
authors.initials: MP
authors.lastname: Latash
authors.forename: W R
authors.initials: WR
authors.lastname: Leopold
authors.forename: S A
authors.initials: SA
authors.lastname: Przybranowski
authors.forename: J S
authors.initials: JS
authors.lastname: Sebolt-Leopold
mesh_terms: D019883:Alkyl and Aryl Transferases / Q000037:antagonists & inhibitors*; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002460:Cell Line; D004151:Dipeptides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D051379:Mice; D015394:Molecular Structure; D009374:Neoplasms, Experimental / Q000188:drug therapy; D017368:Protein Prenylation; D051381:Rats; D014407:Tumor Cells, Cultured; D018631:ras Proteins / Q000378:metabolism*
chemical_list: D000970:Antineoplastic Agents; D004151:Dipeptides; D004791:Enzyme Inhibitors; C108921:PD 152440; C108922:benzyloxycarbonyl-histidyl-N-(2-(benzyloxyphenylmethyl))glycine N-(2-methyl-2-phenylpropyl)amide; D019883:Alkyl and Aryl Transferases; C064911:p21(ras) farnesyl-protein transferase; D018631:ras Proteins