title: Gangliocytoma with immature neuronal cell elements in the pituitary of a rat.
abstract: A spontaneous pituitary gangliocytoma with abundant, immature neuronal cell elements was found incidentally in a 109-week-old female Fischer 344 rat. The pituitary parenchyma was largely occupied by a tumor nodule with necrotic and hemorrhagic foci and cyst. The tumor was composed of mature ganglion-like (M) cells, small immature ganglion (I) cells and transitional (T) cells, with a fibrillar matrix. The I and T cells were intermingled with the M cells or were arranged in compact clusters, in which the I cells formed perivascular rosette-like structures, sometimes with mitotic figures. Immunohistochemically, all types of tumor cells were positive for neuron-specific enolase, and only the M cells was positive for chromogranin A. This result may be correlated with the degree of cytodifferentiation.
authors.affiliation: Mitsubishi Chemical Safety Institute Ltd., Ibaraki, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Okazaki
authors.forename: O
authors.initials: O
authors.lastname: Katsuta
authors.forename: M
authors.initials: M
authors.lastname: Yokoyama
authors.forename: Y
authors.initials: Y
authors.lastname: Wako
authors.forename: Y
authors.initials: Y
authors.lastname: Yamagishi
authors.forename: M
authors.initials: M
authors.lastname: Tsuchitani
mesh_terms: D000818:Animals; D053379:Chromogranin A; D002864:Chromogranins / Q000032:analysis / Q000378:metabolism; D005260:Female; D005729:Ganglioneuroma / Q000737:chemistry / Q000473:pathology / Q000662:veterinary*; D007150:Immunohistochemistry / Q000379:methods; D010751:Phosphopyruvate Hydratase / Q000032:analysis / Q000378:metabolism; D010903:Pituitary Gland, Anterior / Q000737:chemistry / Q000378:metabolism / Q000473:pathology; D010911:Pituitary Neoplasms / Q000737:chemistry / Q000473:pathology / Q000662:veterinary*; D051381:Rats; D011916:Rats, Inbred F344; D012376:Rodent Diseases / Q000378:metabolism / Q000473:pathology*
chemical_list: D053379:Chromogranin A; D002864:Chromogranins; D010751:Phosphopyruvate Hydratase