title: Ocular and systemic reactivity to isoprenaline in patients with insulin-dependent diabetes mellitus.
abstract: There is experimental evidence of decreased beta-adrenergic myocardial sensitivity in patients with insulin-dependent diabetes mellitus (IDDM). In the present study we hypothesized that the ocular response to isoprenaline, as a consequence of increased arterial vessel rigidity, might also be blunted in patients with IDDM. We therefore compared the correlation between systemic pulse pressure amplitude (PPA) and fundus pulsation amplitude (FPA) during intravenous isoprenaline administration in 11 otherwise healthy IDDM patients and 11 healthy control subjects. Ocular fundus pulsations were measured by a recently developed laser interferometric method. Isoprenaline increased PPA in both study groups in a dose-dependent way, but the response was significantly less in IDDM patients (at 0.8 microgram min-1: +38% in control subjects, +27% in IDDM patients, P < 0.05 between groups). Moreover, a dose-dependent increase in FPA was observed, which again was more pronounced in healthy subjects (at 0.8 microgram min-1: +45% in controls, +17% in IDDM patients, P < 0.005 between groups). The regression line between PPA and FPA was very close to the 45 degrees line in healthy subjects, whereas it was significantly flattened in IDDM patients. In conclusion, linear regression between PPA and FPA during isoprenaline suggests arterial stiffening in patients with IDDM. Hence, comparison of systemic PPA and FPA during isoprenaline provocation may be a useful method of estimating changes in arterial capacitance in patients with diabetes mellitus.
authors.affiliation: Department of Clinical Pharmacology, University of Vienna, Austria.
authors.forename: L
authors.initials: L
authors.lastname: Schmetterer
authors.forename: O
authors.initials: O
authors.lastname: Findl
authors.forename: K
authors.initials: K
authors.lastname: Strenn
authors.forename: P
authors.initials: P
authors.lastname: Fasching
authors.forename: G
authors.initials: G
authors.lastname: Zanaschka
authors.forename: H G
authors.initials: HG
authors.lastname: Eichler
authors.forename: M
authors.initials: M
authors.lastname: Wolzt
mesh_terms: D000318:Adrenergic beta-Agonists / Q000494:pharmacology*; D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D003922:Diabetes Mellitus, Type 1 / Q000503:physiopathology*; D005123:Eye / Q000098:blood supply* / Q000187:drug effects; D005654:Fundus Oculi; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007368:Interferometry; D007429:Intraocular Pressure / Q000187:drug effects*; D007545:Isoproterenol / Q000494:pharmacology*; D007834:Lasers; D008297:Male; D008875:Middle Aged; D012039:Regional Blood Flow / Q000187:drug effects; D012044:Regression Analysis
chemical_list: D000318:Adrenergic beta-Agonists; D007545:Isoproterenol