Targeted therapy for lymphoma with peptides.
Using the newly developed combinatorial peptide library methods, D-amino acid containing peptides that are specific against pan-B cell markers such as CD19, CD20, and CD22 can potentially be identified. These peptides can then be used as targeting agents for human lymphoma.
Lam
K S
KS
Arizona Cancer Center, Tucson, USA.
Zhao
Z G
ZG
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology / Q000627:therapeutic use; D000951:Antigens, Neoplasm / Q000276:immunology; D000954:Antigens, Surface / Q000276:immunology / Q000378:metabolism; D006801:Humans; D007130:Immunoglobulin Idiotypes / Q000276:immunology; D008223:Lymphoma / Q000175:diagnosis / Q000188:drug therapy* / Q000276:immunology / Q000378:metabolism; D008565:Membrane Proteins / Q000378:metabolism*; D051379:Mice; D009363:Neoplasm Proteins / Q000378:metabolism*; D010446:Peptide Fragments / Q000138:chemical synthesis / Q000378:metabolism / Q000627:therapeutic use*; D019151:Peptide Library; D011485:Protein Binding; D013329:Structure-Activity Relationship
D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm; D000954:Antigens, Surface; D007130:Immunoglobulin Idiotypes; D008565:Membrane Proteins; D009363:Neoplasm Proteins; D010446:Peptide Fragments; D019151:Peptide Library