title: Eurycoma longifolia Jack enhances libido in sexually experienced male rats.
abstract: The effects of Eurycoma longifolia Jack were studied on the libido of sexually experienced male rats after dosing them with 200, 400 and 800 mg/kg body weight twice daily of different fractions of E. longifolia Jack for 10 days. Results showed that E. longifolia Jack produced a dose-dependent increase in mounting frequency of the treated animals with 400 mg/kg of chloroform, methanol, water and butanol fractions resulting in mounting frequencies of 5.3 +/- 1.2, 4.9 +/- 0.7, 4.8 +/- 0.7 and 5.2 +/- 0.1, and 800 mg/kg further increased them to 5.4 +/- 0.8, 5.4 +/- 0.8, 5.2 +/- 0.6 and 5.3 +/- 0.2 respectively but there were no erections, intromissions, ejaculations or seminal emissions during the 20-min observation period which allowed for the measurement of sexual arousal reflected by mounting frequency uninfluenced by other behavioural components. This study provides evidence that E. longifolia Jack is a potent stimulator of sexual arousal in sexually vigorous male rats in the absence of feedback from genital sensation.
authors.affiliation: School of Pharmaceutical Sciences, University of Science Malaysia, Penang, Malaysia.
authors.forename: H H
authors.initials: HH
authors.lastname: Ang
authors.forename: M K
authors.initials: MK
authors.lastname: Sim
mesh_terms: D000818:Animals; D001046:Aphrodisiacs / Q000008:administration & dosage; D004305:Dose-Response Relationship, Drug; D007989:Libido; D008297:Male; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology*; D010946:Plants, Medicinal; D051381:Rats; D017207:Rats, Sprague-Dawley / Q000523:psychology*; D012726:Sexual Behavior, Animal / Q000187:drug effects*
chemical_list: D001046:Aphrodisiacs; D010936:Plant Extracts