title: SigmaE is an essential sigma factor in Escherichia coli.
abstract: SigmaE is an alternative sigma factor that controls the extracytoplasmic stress response in Escherichia coli. SigmaE is essential at high temperatures but was previously thought to be nonessential at temperatures below 37 degrees C. We present evidence that sigmaE is an essential sigma factor at all temperatures. Cells lacking sigmaE are able to grow at low temperatures because of the presence of a frequently arising, unlinked suppressor mutation.
authors.affiliation: Department of Bacteriology, University of Wisconsin-Madison, 53706, USA.
authors.forename: A
authors.initials: A
authors.lastname: De Las Peñas
authors.forename: L
authors.initials: L
authors.lastname: Connolly
authors.forename: C A
authors.initials: CA
authors.lastname: Gross
mesh_terms: D004926:Escherichia coli / Q000235:genetics / Q000254:growth & development*; D016296:Mutagenesis; D011994:Recombinant Proteins / Q000096:biosynthesis; D012808:Sigma Factor / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D013489:Suppression, Genetic; D013696:Temperature; D014157:Transcription Factors / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D014161:Transduction, Genetic
chemical_list: D011994:Recombinant Proteins; D012808:Sigma Factor; D014157:Transcription Factors; C063202:sporulation-specific sigma factors