The role of DNA demethylation during development.
The somatic genomic methylation pattern which plays a role in the suppression of basal gene activity is established anew in each generation through developmentally regulated de novo and demethylation steps. Demethylation appears to be carried out by a nucleotide exchange reaction which may involve RNA molecules, and is directed to specific loci in the genome through interactions between cis acting elements and trans acting factors.
Weiss
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A
Department of Cellular Biochemistry, Hebrew University Medical School, Jerusalem, Israel.
Cedar
H
H
D000818:Animals; D019175:DNA Methylation; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D008954:Models, Biological; D009928:Organ Specificity