Low-level release of Shiga-like toxin (verocytotoxin) and endotoxin from enterohemorrhagic Escherichia coli treated with imipenem.
Shiga-like toxin (SLT) and endotoxin may participate in the pathogenesis of enterohemorrhagic Escherichia coli (EHEC) infection. Levels of release of SLT and endotoxin from EHEC treated in vitro with antibiotics were estimated. There were differential levels of release of SLT and endotoxin from EHEC treated with different antibiotics. Treatment of EHEC strains, namely, E. coli O157, O111, and O26, with imipenem induced much lower levels of release of SLT and endotoxin than treatment with ceftazidime.
Takahashi
K
K
Department of Microbiology and Immunology, Aichi Medical University, Nagakute, Japan.
Narita
K
K
Kato
Y
Y
Sugiyama
T
T
Koide
N
N
Yoshida
T
T
Yokochi
T
T
D001427:Bacterial Toxins / Q000378:metabolism*; D015780:Carbapenems / Q000494:pharmacology*; D004731:Endotoxins / Q000378:metabolism*; D004926:Escherichia coli / Q000187:drug effects / Q000378:metabolism*; D015378:Imipenem / Q000494:pharmacology*; D007700:Kinetics; D022622:Shiga Toxin 1
D001427:Bacterial Toxins; D015780:Carbapenems; D004731:Endotoxins; D022622:Shiga Toxin 1; D015378:Imipenem