The leukocyte cell adhesion cascade and its role in myocardial ischemia-reperfusion injury.
Cell-cell and cell-matrix interactions are known to be mediated by specific cell adhesion receptors expressed on the cell surface. The characterization of these cell adhesion molecules has allowed researchers to examine their roles in a variety of physiologic and pathophysiologic conditions. Numerous studies have demonstrated that myocardial ischemia-reperfusion injury is an acute inflammatory process in which leukocytes are intimately involved. In this review, we summarize the current data on the leukocyte cell adhesion cascade, focus upon studies which have demonstrated specific cell adhesion molecule interactions which mediate the leukocyte involvement in myocardial ischemia-reperfusion injury and suggest future avenues of exploration and possible clinical implications of the studies reviewed.
Gumina
R J
RJ
Blood Research Institute, Blood Center of Southeastern Wisconsin Milwaukee 53213, USA.
Newman
P J
PJ
Kenny
D
D
Warltier
D C
DC
Gross
G J
GJ
D000818:Animals; D015815:Cell Adhesion Molecules / Q000502:physiology*; D006801:Humans; D007962:Leukocytes / Q000502:physiology*; D015428:Myocardial Reperfusion Injury / Q000209:etiology / Q000503:physiopathology*; D016028:Receptors, Leukocyte-Adhesion / Q000502:physiology
D015815:Cell Adhesion Molecules; D016028:Receptors, Leukocyte-Adhesion