Switching gears during T-cell maturation: RANTES and late transcription.
Although much is understood about the induction of genes expressed early (within 24 h) after T-cell activation, little is known about the regulation of expression of genes expressed 'late' (three or more days) post-stimulation. A better understanding of transcriptional regulation at this important stage of T-cell maturation may yield new insights into T-cell development and new immunotherapeutic targets.
Ortiz
B D
BD
Division of Immunology, University of California, Berkeley 94720-3200, USA.
Nelson
P J
PJ
Krensky
A M
AM
D000818:Animals; D002454:Cell Differentiation; D018946:Chemokine CCL5 / Q000235:genetics*; D006801:Humans; D007167:Immunotherapy; D008213:Lymphocyte Activation / Q000235:genetics; D011401:Promoter Regions, Genetic; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology* / Q000378:metabolism; D013997:Time Factors; D014157:Transcription Factors / Q000378:metabolism; D014158:Transcription, Genetic
D018946:Chemokine CCL5; D014157:Transcription Factors