Pathogenesis of dengue virus diseases: missing pieces in the jigsaw.
The mechanisms involved in the pathogenesis of dengue hemorrhagic fever and dengue shock syndrome remain unresolved. Antibody-dependent enhancement of infection has long been thought to play a central role; however, this remains unverified. The alternative hypothesis that virus variation, virulence and dynamics may account for severe dengue disease, particularly in children, should be considered.
Bielefeldt-Ohmann
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Centre for Molecular Biotechnology (Arbovirology Group), School of Life Science, Queensland University of Technology, Brisbane, Australia. helle@biosci.ug.edu.au
D000818:Animals; D003716:Dengue Virus / Q000276:immunology / Q000472:pathogenicity*; D006801:Humans; D019595:Severe Dengue / Q000276:immunology / Q000821:virology*