Application of human liver microsomes in metabolism-based drug-drug interactions: in vitro-in vivo correlations and the Abbott Laboratories experience.
Rodrigues
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AD
Drug Metabolism Department, Abbott Laboratories, Abbott Park, Illinois 60064-3500, USA.
Wong
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SL
D000818:Animals; D017291:Clarithromycin / Q000493:pharmacokinetics; D065607:Cytochrome P-450 Enzyme Inhibitors; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D003891:Desipramine / Q000493:pharmacokinetics; D004353:Drug Evaluation, Preclinical / Q000379:methods; D004347:Drug Interactions; D006801:Humans; D007527:Isoenzymes / Q000037:antagonists & inhibitors / Q000378:metabolism; D008862:Microsomes, Liver / Q000378:metabolism*; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D019438:Ritonavir / Q000494:pharmacology; D016593:Terfenadine / Q000378:metabolism
D065607:Cytochrome P-450 Enzyme Inhibitors; D007527:Isoenzymes; D004364:Pharmaceutical Preparations; D016593:Terfenadine; D003577:Cytochrome P-450 Enzyme System; D017291:Clarithromycin; D019438:Ritonavir; D003891:Desipramine