title: Insulin-like growth factor-binding protein-1 in human follicular fluid: a marker for oocyte maturation.
abstract: In order to investigate the role of insulin-like growth factors (IGFs) in human ovulation, we evaluated the concentrations of IGF-binding proteins (IGFBPs) in human follicular fluid (FF). The concentrations of IGFBP-1 in the FFs of 15 women undergoing in vitro fertilization and embryo transfer were measured and related to those of 17beta-estradiol (E2), progesterone and androstenedione in the FFs. IGFBP-1 levels in the FFs were positively correlated with those of E2 and progesterone. No correlation was found between the IGFBP-1 and androstenedione levels in FFs. The concentrations of IGFBP-1 were significantly increased in the FFs which contained mature oocytes compared with those of immature oocytes, whereas IGFBP-3 in FFs tended to decrease as oocytes matured. It is suggested that IGFs may play important roles in human preovulatory processes, and that IGFBP-1 may be a valuable biochemical marker in the evaluation of oocytes.
authors.affiliation: Department of Obstetrics and Gynecology, Oita Medical University, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Kawano
authors.forename: H
authors.initials: H
authors.lastname: Narahara
authors.forename: N
authors.initials: N
authors.lastname: Matsui
authors.forename: K
authors.initials: K
authors.lastname: Nasu
authors.forename: K
authors.initials: K
authors.lastname: Miyamura
authors.forename: I
authors.initials: I
authors.lastname: Miyakawa
mesh_terms: D000735:Androstenedione / Q000378:metabolism; D015415:Biomarkers; D015153:Blotting, Western; D004624:Embryo Transfer; D004797:Enzyme-Linked Immunosorbent Assay; D004958:Estradiol / Q000378:metabolism; D005260:Female; D005307:Fertilization in Vitro; D015571:Follicular Fluid / Q000378:metabolism*; D006801:Humans; D007247:Infertility, Female / Q000378:metabolism / Q000628:therapy; D018970:Insulin-Like Growth Factor Binding Protein 1 / Q000378:metabolism*; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000378:metabolism; D009865:Oocytes / Q000502:physiology*; D009866:Oogenesis / Q000502:physiology*; D011374:Progesterone / Q000378:metabolism; D011863:Radioimmunoassay
chemical_list: D015415:Biomarkers; D018970:Insulin-Like Growth Factor Binding Protein 1; D018972:Insulin-Like Growth Factor Binding Protein 3; D000735:Androstenedione; D011374:Progesterone; D004958:Estradiol