title: Sequential mechanical and pharmacological thromboprophylaxis in the surgery of hip fractures. A pilot study.
abstract: Two hundred and thirty-eight patients with femoral neck fractures were entered into a randomised pilot study comparing the use of sequential treatment by 'Flowtron DVT' garments in the perioperative period followed by Enoxaparin (Clexane-Rhône-Poulenc Rorer), and Enoxaparin alone. One hundred and ninety-three patients were excluded indicating the difficulty of achieving pure comparisons in this population. The remaining 44 were randomised: 21 received Enoxaparin from the time of admission, and 23 had sequential treatment. There was no statistically significant difference in the incidence of thromboembolism. Patient preference did not indicate a favoured treatment subjectively. The operation field was drier in the sequential group, although this did not reach significance. Sequential treatment was not shown to be better or worse than treatment with Enoxaparin, but the trends favoured sequential treatment rather than drug treatment alone. The technique allows the operation to be carried out without the problems produced by low dose heparins and mobilisation is not hindered by compression garments.
authors.affiliation: Academic Department of Orthopaedic Surgery, General Infirmary, Leeds, UK.
authors.forename: M B
authors.initials: MB
authors.lastname: Eskander
authors.forename: D
authors.initials: D
authors.lastname: Limb
authors.forename: M H
authors.initials: MH
authors.lastname: Stone
authors.forename: A J
authors.initials: AJ
authors.lastname: Furlong
authors.forename: D
authors.initials: D
authors.lastname: Shardlow
authors.forename: D
authors.initials: D
authors.lastname: Stead
authors.forename: G
authors.initials: G
authors.lastname: Culleton
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000925:Anticoagulants / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D017984:Enoxaparin / Q000627:therapeutic use*; D005260:Female; D005265:Femoral Neck Fractures / Q000601:surgery*; D005676:Gravity Suits; D006801:Humans; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D011182:Postoperative Care; D011183:Postoperative Complications / Q000453:epidemiology / Q000517:prevention & control*; D011655:Pulmonary Embolism / Q000453:epidemiology / Q000517:prevention & control; D013924:Thrombophlebitis / Q000453:epidemiology / Q000517:prevention & control*; D016896:Treatment Outcome
chemical_list: D000925:Anticoagulants; D017984:Enoxaparin