Impact of protease inhibitors on AIDS-defining events and hospitalizations in 10 French AIDS reference centres. Fédération National des Centres de Lutte contre le SIDA.
OBJECTIVE
To assess the clinical and economic consequences of the use of protease inhibitors in the treatment of HIV infection.


METHODS
Multicentric, observational, retrospective cohort study.


METHODS
Ten AIDS reference centres in France.


METHODS
All patients followed in each centre from September 1995 through October 1996.


METHODS
AIDS-defining events, death, health-care resources use, administration of antiretroviral therapy.


RESULTS
Data from 7749 patients in 10 centres showed a drop in hospitalization days by 35%, new AIDS cases by 35%, and deaths by 46%. In the same period, the proportion of patients receiving antiretrovirals rose from 36 to 53% including highly active antiretroviral therapy (HAART), which rose from 0.3 to 18%. Overall cost evaluation showed a slight increase of monthly treatment cost of US$ 12 per patient. Comparison of the three centres that used HAART earliest to the three centres that used it latest showed a clear benefit to early HAART with a drop in hospitalization days by 41%, new AIDS cases by 41% and deaths by 69%. The proportion of patients with HAART rose to 27% and monthly health-care cost decreased by US$ 248852 (i.e., by US$ 101 per patient per month). Late prescribing centres experienced a less marked effect with a drop in hospitalization days by 22%, new AIDS cases by 31%, and deaths by 32.5%. Proportion of patients with HAART rose to 12% and monthly health-care costs increased by US$ 113578 (i.e., by US$ 38 per patient per month).


CONCLUSIONS
This study supports the extensive use of HAART in HIV-infected patients.
Mouton
Y
Y
Service des Maladies Infectieuses, Centre Hospitalier, Tourcoing, France.
Alfandari
S
S
Valette
M
M
Cartier
F
F
Dellamonica
P
P
Humbert
G
G
Lang
J M
JM
Massip
P
P
Mechali
D
D
Leclercq
P
P
Modai
J
J
Portier
H
H
D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy* / Q000191:economics; D019380:Anti-HIV Agents / Q000191:economics / Q000627:therapeutic use*; D015331:Cohort Studies; D016527:Drug Costs; D017320:HIV Protease Inhibitors / Q000191:economics / Q000627:therapeutic use*; D017721:Hospital Costs; D006760:Hospitalization; D006801:Humans; D010043:Outcome and Process Assessment, Health Care; D012189:Retrospective Studies
D019380:Anti-HIV Agents; D017320:HIV Protease Inhibitors