Analysis of trifluoroacetic acid in lyophilized natural products by capillary electrophoresis.
A rapid and simple method for the capillary electrophoretic determination of residual trifluoroacetic acid in lyophilized natural products is described. The technique utilizes 2,6-naphthalenedicarboxylic acid as a separation buffer additive providing indirect ultraviolet absorption detection. Using this method, acceptable precision, accuracy, selectivity, range and linearity were achieved.
Strege
M A
MA
Lilly Research Laboratories, Eli Lilly and Co., Indianapolis, IN 46285, USA.
Mascher
W G
WG
D003998:Dicarboxylic Acids; D004340:Drug Contamination; D019075:Electrophoresis, Capillary; D005612:Freeze Drying; D008074:Lipoproteins / Q000032:analysis*; D009281:Naphthalenes; D010455:Peptides / Q000032:analysis*; D012680:Sensitivity and Specificity; D013056:Spectrophotometry, Ultraviolet; D014269:Trifluoroacetic Acid / Q000032:analysis*
D003998:Dicarboxylic Acids; D008074:Lipoproteins; D009281:Naphthalenes; D010455:Peptides; C109064:2,6-naphthalenedicarboxylic acid; D014269:Trifluoroacetic Acid