Nephrotoxicity associated with cyclosporine and FK506.
In conclusion, nephrotoxicity is a common and potentially clinically significant problem with cyclosporine and FK506 following transplantation. Further definition of its pathogenesis and improved dosing strategies for both of these drugs may reduce the impact of nephrotoxicity on both short-term and long-term outcomes.
Klintmalm
G B
GB
Baylor University Medical Center, Dallas, TX 75246, USA.
Gonwa
T A
TA
D000818:Animals; D016572:Cyclosporine / Q000009:adverse effects* / Q000627:therapeutic use; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006084:Graft Rejection / Q000276:immunology / Q000517:prevention & control*; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D007668:Kidney / Q000187:drug effects* / Q000503:physiopathology; D016377:Organ Transplantation; D016559:Tacrolimus / Q000009:adverse effects* / Q000627:therapeutic use
D007166:Immunosuppressive Agents; D016572:Cyclosporine; D016559:Tacrolimus