title: Adenoviral vectors for gene transfer.
abstract: Adenoviruses began to be developed into highly effective gene expression vectors in the early 1980s. Recently, the increased interest in utilizing this transfer system in vivo has posed new problems for heterologous gene-transfer, spurring a renewed effort in the field of vector development toward solving the structural, immunological and targeting problems posed by gene therapy applications.
authors.affiliation: GenVec Inc., Rockville, MD 20852, USA. kovesdi@genvec.com
authors.forename: I
authors.initials: I
authors.lastname: Kovesdi
authors.forename: D E
authors.initials: DE
authors.lastname: Brough
authors.forename: J T
authors.initials: JT
authors.lastname: Bruder
authors.forename: T J
authors.initials: TJ
authors.lastname: Wickham
mesh_terms: D000256:Adenoviridae / Q000235:genetics*; D000818:Animals; D000917:Antibody Formation; D016207:Cytokines / Q000096:biosynthesis; D015316:Genetic Therapy / Q000379:methods; D005822:Genetic Vectors; D006801:Humans; D007111:Immunity, Cellular; D007167:Immunotherapy / Q000379:methods; D011994:Recombinant Proteins / Q000096:biosynthesis*; D014162:Transfection / Q000379:methods*
chemical_list: D016207:Cytokines; D011994:Recombinant Proteins