Clinical significance of cytokine measurement for detection of meningitis.
Levels of interleukin-6 and tumor necrosis factor alpha were measured in cerebrospinal fluids from patients with meningitis. Interleukin-6 was increased in aseptic and bacterial meningitis, whereas tumor necrosis factor alpha was increased only in bacterial meningitis. We concluded that measurement of cytokines in cerebrospinal fluid may be useful for the rapid diagnosis of meningitis.
Azuma
H
H
Department of Pediatrics, Asahikawa Medical College, Hokkaido, Japan.
Tsuda
N
N
Sasaki
K
K
Okuno
A
A
D016022:Case-Control Studies; D002555:Cerebrospinal Fluid / Q000166:cytology; D002648:Child; D002675:Child, Preschool; D003937:Diagnosis, Differential; D006801:Humans; D007223:Infant; D015850:Interleukin-6 / Q000134:cerebrospinal fluid*; D008582:Meningitis, Aseptic / Q000134:cerebrospinal fluid* / Q000276:immunology*; D016920:Meningitis, Bacterial / Q000134:cerebrospinal fluid* / Q000276:immunology*; D015203:Reproducibility of Results; D014409:Tumor Necrosis Factor-alpha / Q000134:cerebrospinal fluid*
D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha