title: Chagas disease in Ecuador: evidence for disease transmission in an Indigenous population in the Amazon region.
abstract: Two well-defined synthetic peptides TcD and PEP2 were used in a sero-epidemiological study for the detection of Trypanosoma cruzi infections in an indigenous group in the Amazon region of Ecuador. Of the 18 communities studied along the Rio Napo, province of Napo, 15 (83.3%) were found to be positive for T. cruzi infection. Of the 1,011 individuals examined 61 (6.03%) resulted positive. A prevalence of infection of 4.8% was found in children aged 1-5 years. The prevalence of infection increased with age, with adults 50 years or older showing a maximum prevalence of 18.8%. Autochthonous transmission of T. cruzi is present among this isolated indigenous population.
authors.affiliation: Departamento de Investigaciones Clínicas, Hospital Vozandes, HCJB, Quito, Ecuador.
authors.forename: M
authors.initials: M
authors.lastname: Chico
authors.forename: C
authors.initials: C
authors.lastname: Sandoval
authors.forename: A
authors.initials: A
authors.lastname: Guevara
authors.forename: M
authors.initials: M
authors.lastname: Calvopiña
authors.forename: P J
authors.initials: PJ
authors.lastname: Cooper
authors.forename: S G
authors.initials: SG
authors.lastname: Reed
authors.forename: R H
authors.initials: RH
authors.lastname: Guderian
mesh_terms: D000293:Adolescent; D014355:Chagas Disease / Q000453:epidemiology* / Q000635:transmission*; D002648:Child; D002675:Child, Preschool; D004484:Ecuador / Q000453:epidemiology; D005260:Female; D006801:Humans; D007199:Indians, South American; D007223:Infant; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D016036:Seroepidemiologic Studies