title: Absence of hepatitis C virus transmission but frequent transmission of HIV-1 from sexual contact with doubly-infected individuals.
abstract: Hepatitis C virus (HCV) is transmitted through infected blood and blood products, but evidence of other routes of transmission is less clearly understood. In a study designed to examine human immunodeficiency virus (HIV) transmission, the prevalence of HCV has also been measured. Sixty-one couples were analysed, 30 in which partners were at risk through sexual contact alone, of whom 12 (40%) became infected with HIV and none with HCV. Thirty-one partners were exposed sexually and additionally through intravenous drug use. Of these, 16 (52%) became infected with HIV and 25 (80%) contracted HCV infection. These findings support the evidence of others that HCV is only rarely transmitted by sexual intercourse in heterosexual relationships and that HIV is not a co-factor for HCV transmission.
authors.affiliation: Muirhouse Medical Group, Edinburgh, U.K.
authors.forename: R
authors.initials: R
authors.lastname: Wyld
authors.forename: J R
authors.initials: JR
authors.lastname: Robertson
authors.forename: R P
authors.initials: RP
authors.lastname: Brettle
authors.forename: J
authors.initials: J
authors.lastname: Mellor
authors.forename: L
authors.initials: L
authors.lastname: Prescott
authors.forename: P
authors.initials: P
authors.lastname: Simmonds
mesh_terms: D000293:Adolescent; D000328:Adult; D018562:Disease Transmission, Infectious; D005260:Female; D015658:HIV Infections / Q000635:transmission*; D015497:HIV-1; D016174:Hepacivirus; D006526:Hepatitis C / Q000635:transmission*; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D012749:Sexually Transmitted Diseases / Q000635:transmission*; D018454:Spouses