title: Progressive multifocal leukoencephalopathy in AIDS: initial and follow-up CT and MRI.
abstract: We sought to determine the value of follow-up CT and MRI in patients with acquired immuno-deficiency syndrome (AIDS) and progressive multifocal leukoencephalopathy (PML). We reviewed 50 CT and 19 MRI examinations performed in 21 biopsy- or autopsy-proven cases of PML; 17 patients had follow-up examinations (mean time 5.9 weeks). The radiological examinations were correlated with pathological findings at autopsy. On initial imaging studies, 73 lesions were found. On follow-up, the most striking feature was rapid progression in both size and number of the lesions (from a mean of 3.2 to 6.9 per patient). One third of the patients showed increasing mass effect. A central area suggesting necrosis, of variable size, was found in 12/16 patients. Autopsy revealed macroscopic necrotic changes in the lesions in 11/16 patients.
authors.affiliation: Department of Radiology, University of Vienna, Austria.
authors.forename: M M
authors.initials: MM
authors.lastname: Thurnher
authors.forename: S A
authors.initials: SA
authors.lastname: Thurnher
authors.forename: B
authors.initials: B
authors.lastname: Mühlbauer
authors.forename: J A
authors.initials: JA
authors.lastname: Hainfellner
authors.forename: A
authors.initials: A
authors.lastname: Steuer
authors.forename: D
authors.initials: D
authors.lastname: Fleischmann
authors.forename: S
authors.initials: S
authors.lastname: Trattnig
authors.forename: H
authors.initials: H
authors.lastname: Budka
authors.forename: E
authors.initials: E
authors.lastname: Schindler
mesh_terms: D015526:AIDS Dementia Complex / Q000175:diagnosis*; D000328:Adult; D001706:Biopsy; D001921:Brain / Q000473:pathology*; D002540:Cerebral Cortex / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007968:Leukoencephalopathy, Progressive Multifocal / Q000175:diagnosis*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009336:Necrosis; D014057:Tomography, X-Ray Computed