Removal of catheter distortion in multiple indicator dilution studies: a deconvolution-based method and case studies on glucose blood-tissue exchange.
The study of blood-tissue exchange by the multiple indicator dilution technique often needs frequent sampling in the blood of the indicator dilution curves (IDC). Usually, this requires the use of a catheter supported by a pump. This causes a distortion in the IDC, which must be removed for proper interpretation of the data. A deconvolution-based methodology to remove IDC distortion is presented. First, the catheter impulse response is modelled by means of data obtained from a suitable experiment. Then the reconstruction of the blood IDC is tackled by a new nonparametric deconvolution algorithm, which provides (quasi) time-continuous signals and exploits statistically based criteria for the choice of the regularisation parameter. The methodology is applied to the removal of catheter distortion in studies of glucose blood-tissue exchange in the human forearm and myocardium.
Sparacino
G
G
Department of Electronics and Informatics, University of Padova, Italy.
Vicini
P
P
Bonadonna
R
R
Marraccini
P
P
Lehtovirta
M
M
Ferrannini
E
E
Cobelli
C
C
D001786:Blood Glucose / Q000378:metabolism*; D001800:Blood Specimen Collection; D002404:Catheterization; D005542:Forearm; D006801:Humans; D008954:Models, Biological; D009206:Myocardium / Q000378:metabolism; D011865:Radioisotope Dilution Technique
D001786:Blood Glucose