title: 6-Chloro-5-methyl-1-[[2-[(2-methyl-3-pyridyl)oxy]-5-pyridyl]carbamoyl]- indoline (SB-242084): the first selective and brain penetrant 5-HT2C receptor antagonist.
authors.affiliation: SmithKline Beecham Pharmaceuticals, Discovery Research, Harlow, Essex, England.
authors.forename: S M
authors.initials: SM
authors.lastname: Bromidge
authors.forename: M
authors.initials: M
authors.lastname: Duckworth
authors.forename: I T
authors.initials: IT
authors.lastname: Forbes
authors.forename: P
authors.initials: P
authors.lastname: Ham
authors.forename: F D
authors.initials: FD
authors.lastname: King
authors.forename: K M
authors.initials: KM
authors.lastname: Thewlis
authors.forename: F E
authors.initials: FE
authors.lastname: Blaney
authors.forename: C B
authors.initials: CB
authors.lastname: Naylor
authors.forename: T P
authors.initials: TP
authors.lastname: Blackburn
authors.forename: G A
authors.initials: GA
authors.lastname: Kennett
authors.forename: M D
authors.initials: MD
authors.lastname: Wood
authors.forename: S E
authors.initials: SE
authors.lastname: Clarke
mesh_terms: D000631:Aminopyridines / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology*; D000818:Animals; D001812:Blood-Brain Barrier; D002460:Cell Line; D065607:Cytochrome P-450 Enzyme Inhibitors; D004791:Enzyme Inhibitors / Q000494:pharmacology; D006801:Humans; D007211:Indoles / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology*; D015394:Molecular Structure; D051381:Rats; D044405:Receptor, Serotonin, 5-HT2C; D011985:Receptors, Serotonin / Q000187:drug effects*; D012702:Serotonin Antagonists / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology*
chemical_list: C107820:6-chloro-5-methyl-1-((2-(2-methylpyrid-3-yloxy)pyrid-5-yl)carbamoyl)indoline; D000631:Aminopyridines; D065607:Cytochrome P-450 Enzyme Inhibitors; D004791:Enzyme Inhibitors; D007211:Indoles; D044405:Receptor, Serotonin, 5-HT2C; D011985:Receptors, Serotonin; D012702:Serotonin Antagonists