title: Prospects for respiratory gene therapy.
abstract: Over the last 5 years a number of articles have been published on gene therapy for a range of diseases. The initial tone of a number of these articles evoked high expectations, particularly from the public. Over the last 2-3 years data from these studies have begun to filter through and, perhaps not surprisingly, initial problems have been encountered, resulting in a recent spate of bad press for gene therapy. This article aims to examine where the prospects for respiratory gene therapy lie in the face of these mixed reactions.
authors.affiliation: Ion Transport Unit, National Heart and Lung Institute, London.
authors.forename: E W
authors.initials: EW
authors.lastname: Alton
authors.forename: D M
authors.initials: DM
authors.lastname: Geddes
mesh_terms: D000260:Adenoviruses, Human; D000818:Animals; D017321:Clinical Trials, Phase I as Topic; D003550:Cystic Fibrosis / Q000628:therapy; D015870:Gene Expression; D018390:Gene Targeting; D018014:Gene Transfer Techniques; D015316:Genetic Therapy; D006801:Humans; D066298:In Vitro Techniques; D008171:Lung Diseases / Q000628:therapy*; D008175:Lung Neoplasms / Q000628:therapy; D051379:Mice; D019896:alpha 1-Antitrypsin Deficiency / Q000628:therapy