Diabetes mellitus.
Epidemiological studies have documented a high prevalence of diabetic neuropathy. The risk of lower leg amputation is increased three to four times in patients with clinical signs of neuropathy and ankle weakness is more common than hitherto recognized. Increased nerve hydration and increased expression of low affinity p75 receptor for neurotrophins suggest new therapeutic potentials for the prevention of diabetic neuropathy.
Andersen
H
H
Department of Neurology, Aarhus University Hospital, Denmark.
Jakobsen
J
J
D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000175:diagnosis*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000175:diagnosis*; D003929:Diabetic Neuropathies / Q000175:diagnosis* / Q000209:etiology / Q000517:prevention & control; D006801:Humans; D009460:Neurologic Examination; D012307:Risk Factors