title: Subcapsular cell hyperplasia and mast cell infiltration in the adrenal cortex of mice: comparative study in 7 inbred strains.
abstract: Subcapsular cell hyperplasia (SCH) in the adrenal cortex of aged mice (13-15 months old) was frequent in both sexes of BALB/c, C3H/He, DBA/2J and IQI/Jic mice and in the females of A/J and C57BL/6, although the incidence and severity of SCH were considerably different among mouse strains. Mast cells were closely associated with SCH in the A/J, BALB/c, C57BL/6, DBA/2J and IQI/Jic mice, but not in the C3H/He strain. Compared with other strains, IQI/Jic mice had a significantly larger number of mast cells in the adrenal glands. Our findings suggest that mast cells may participate in the development of SCH, and IQI/Jic would be suitable for studying the pathogenesis of SCH and the role of mast cells in this lesion.
authors.affiliation: Laboratory of Experimental Toxicology, National Institute of Industrial Health, Kawasaki, Japan.
authors.forename: J S
authors.initials: JS
authors.lastname: Kim
authors.forename: H
authors.initials: H
authors.lastname: Kubota
authors.forename: Y
authors.initials: Y
authors.lastname: Kiuchi
authors.forename: K
authors.initials: K
authors.lastname: Doi
authors.forename: J
authors.initials: J
authors.lastname: Saegusa
mesh_terms: D000303:Adrenal Cortex Diseases / Q000209:etiology / Q000473:pathology / Q000662:veterinary*; D000311:Adrenal Glands / Q000166:cytology / Q000473:pathology*; D000818:Animals; D005260:Female; D006965:Hyperplasia / Q000209:etiology; D008297:Male; D008407:Mast Cells / Q000502:physiology*; D051379:Mice; D008815:Mice, Inbred Strains / Q000033:anatomy & histology*