Autoimmune progesterone dermatitis: effective prophylactic treatment with danazol.
BACKGROUND
Autoimmune progesterone dermatitis is a rare condition appearing during the perimenstrual period or following progesterone treatment. Various treatment modalities have been suggested, but most have proved to be ineffective.


METHODS
We used the anabolic androgen danazol as a preventive treatment for recurrent episodes of autoimmune progesterone dermatitis in two young women. The treatment regimen consisted of 200 mg danazol twice daily, starting 1-2 days before the expected date of each menses and continuing for 3 days thereafter.


RESULTS
This treatment regimen proved to be highly effective in preventing the eruptions in these two patients.


CONCLUSIONS
Patients with autoimmune progesterone dermatitis may benefit from prophylactic treatment with danazol.
Shahar
E
E
Institute of Allergy, Clinical Immunology, and AIDS, Rambam Medical Center, Haifa, Israel.
Bergman
R
R
Pollack
S
S
D000328:Adult; D001327:Autoimmune Diseases / Q000139:chemically induced / Q000276:immunology / Q000473:pathology / Q000517:prevention & control*; D001707:Biopsy, Needle; D003613:Danazol / Q000627:therapeutic use*; D003872:Dermatitis / Q000276:immunology / Q000473:pathology / Q000517:prevention & control*; D003875:Drug Eruptions / Q000473:pathology / Q000517:prevention & control; D004965:Estrogen Antagonists / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008597:Menstrual Cycle / Q000276:immunology; D011374:Progesterone / Q000009:adverse effects / Q000276:immunology*
D004965:Estrogen Antagonists; D011374:Progesterone; D003613:Danazol