title: Pharmacokinetics of a porcine insulin zinc suspension in diabetic dogs.
abstract: Ten dogs with naturally occurring diabetes mellitus were injected with a highly purified porcine insulin zinc suspension at a dose according to their expected requirement. Plasma insulin and glucose concentrations were measured at two-hourly intervals over 24 hours following injection. There were either one or two peaks in plasma insulin concentration: one at about four hours (mean 4.3 +/- 1.3 [SD]) and another at about 11 hours (mean 11 +/- 1.85) after the injection. The second insulin peak was seen in only eight dogs. Persistence of elevated plasma insulin concentrations ranged from 14 to 24 hours (mean 17.4 +/- 3.65). These results compare favourably with those published for other intermediate-acting insulin preparations used to treat canine diabetes mellitus and suggest that this preparation has useful properties for the successful management of many canine diabetics.
authors.affiliation: Department of Veterinary Clinical Studies, University of Glasgow.
authors.forename: P A
authors.initials: PA
authors.lastname: Graham
authors.forename: A S
authors.initials: AS
authors.lastname: Nash
authors.forename: Q A
authors.initials: QA
authors.lastname: McKellar
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D003920:Diabetes Mellitus / Q000097:blood / Q000188:drug therapy / Q000662:veterinary*; D004283:Dog Diseases / Q000097:blood* / Q000188:drug therapy; D004285:Dogs; D005260:Female; D007004:Hypoglycemic Agents / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use; D049528:Insulin, Long-Acting / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use; D008297:Male; D019518:Postprandial Period; D013552:Swine
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D049528:Insulin, Long-Acting