[Current problems of regulation of adrenocortical function].
The currently available data on the regulation of corticosteroid secretion are analyzed. ACTH is the main regulator during acute stress. It accelerates the biosynthesis of glucocorticoids at the stage of cholesterol delivery to the mitochondrial inner membrane where the latter is converted to pregnenolone by side-chain cleavage. The Steroidogenic Acute Regulatory Protein (STAR) could play a great role in the supply of mitochondria with cholesterol. Under chronic stress, adrenal hypertrophy is largely involved in higher corticosteroid formation. Neuropeptides, cytokines, and growth factors modulate adrenal function. Prolactin which plays a role as a mitogenic factor in many tissues takes an active part in the control of adrenal function and proliferation.
Mikosha
A S
AS
Institute of Endocrynology of Metabolism AMN of Ukraine, Kiev.
D000302:Adrenal Cortex / Q000502:physiology*; D000324:Adrenocorticotropic Hormone / Q000096:biosynthesis; D000818:Animals; D001692:Biological Transport / Q000502:physiology; D005938:Glucocorticoids / Q000096:biosynthesis; D006801:Humans
D005938:Glucocorticoids; D000324:Adrenocorticotropic Hormone