title: Elevation of soluble adhesion molecules is associated with the severity of myocardial damage in acute myocardial infarction.
abstract: In 20 patients with acute myocardial infarction, blood samples were taken to study the serial changes in the soluble intercellular adhesion molecule-1 (ICAM-1), vascular cellular adhesion molecule-1 (VCAM-1) and E-selectin. Results indicated that soluble ICAM-1 increased significantly and persisted throughout the study period; however, soluble E-selectin was significantly elevated only transiently and decreased rapidly thereafter, and the VCAM-1 did not increase during entire study period. There was a significant correlation between the levels of ICAM-1, E-selectin 6 hours after admission, and peak creatine kinase level; the levels of ICAM-1 and E-selectin were also positively correlated with total leukocyte count at admission.
authors.affiliation: Department of Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan, Republic of China.
authors.forename: Y H
authors.initials: YH
authors.lastname: Li
authors.forename: J K
authors.initials: JK
authors.lastname: Teng
authors.forename: W C
authors.initials: WC
authors.lastname: Tsai
authors.forename: L M
authors.initials: LM
authors.lastname: Tsai
authors.forename: L J
authors.initials: LJ
authors.lastname: Lin
authors.forename: J H
authors.initials: JH
authors.lastname: Chen
mesh_terms: D016022:Case-Control Studies; D019040:E-Selectin / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000175:diagnosis / Q000473:pathology; D009206:Myocardium / Q000473:pathology*; D019010:Vascular Cell Adhesion Molecule-1 / Q000097:blood*
chemical_list: D019040:E-Selectin; D019010:Vascular Cell Adhesion Molecule-1; D018799:Intercellular Adhesion Molecule-1