title: Histamine modulates NMDA-dependent swelling in the neostriatum.
abstract: In the present study, infrared differential interference contrast videomicroscopy was used to examine the effect of histamine on N-methyl-D-aspartate-induced swelling in neostriatal neurons in a brain slice preparation. Histamine caused a concentration-dependent increase in swelling evoked by N-methyl-D-aspartate. By itself, histamine did not cause swelling. Electrical stimulation also caused N-methyl-D-aspartate-dependent swelling which was enhanced by histamine. In addition, histamine was found to enhance N-methyl-D aspartate-induced swelling from postnatal day 7 to 28 but not at postnatal day 3. Finally, this histamine-induced enhancement was prevented by treatment with either the H2 receptor antagonist cimetidine or with the potassium channel blocker tetraethylammonium chloride. Overall, these findings suggest that histamine modulates N-methyl-D-aspartate receptor function in the neostriatum through a H2 receptor-mediated regulation of potassium channels.
authors.affiliation: Mental Retardation Research Center, University of California-Los Angeles, 90024-1759, USA. ccolwell@npih.mednet.ucla.edu
authors.forename: C S
authors.initials: CS
authors.lastname: Colwell
authors.forename: M S
authors.initials: MS
authors.lastname: Levine
mesh_terms: D000818:Animals; D001929:Brain Edema / Q000503:physiopathology*; D016923:Cell Death / Q000187:drug effects; D004558:Electric Stimulation; D018690:Excitatory Amino Acid Agonists / Q000494:pharmacology; D006632:Histamine / Q000494:pharmacology*; D006633:Histamine Antagonists / Q000494:pharmacology; D008297:Male; D018715:Microscopy, Video; D016202:N-Methylaspartate / Q000494:pharmacology; D017072:Neostriatum / Q000737:chemistry / Q000166:cytology / Q000503:physiopathology*; D009474:Neurons / Q000737:chemistry / Q000473:pathology; D011073:Polyamines / Q000494:pharmacology; D026902:Potassium Channel Blockers; D015221:Potassium Channels / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D016194:Receptors, N-Methyl-D-Aspartate / Q000502:physiology*; D019789:Tetraethylammonium / Q000494:pharmacology; D014343:Trypan Blue
chemical_list: D018690:Excitatory Amino Acid Agonists; D006633:Histamine Antagonists; D011073:Polyamines; D026902:Potassium Channel Blockers; D015221:Potassium Channels; D016194:Receptors, N-Methyl-D-Aspartate; D016202:N-Methylaspartate; D019789:Tetraethylammonium; D006632:Histamine; D014343:Trypan Blue