Chorea-acanthocytosis with polyclonal antibodies to ganglioside GM1.
A patient with chorea-acanthocytosis presenting with axonal neuropathy showed an elevation in IgM polyclonal antibodies to the GM1 ganglioside, which were estimated by enzyme-linked immunosorbent assay and complement-mediated liposome immune lysis assay (LILA). This is the first demonstration of such antibodies in chorea-acanthocytosis. Anti-GM1 antibodies might have directly caused the axonal neuropathy by binding to GM1 or cross-reactive antigens in the nerves.
Hirayama
M
M
Second Department of Internal Medicine, Fukui Medical School, Japan.
Hamano
T
T
Shiratori
M
M
Mutoh
T
T
Kumano
T
T
Aita
T
T
Kuriyama
M
M
D000050:Acanthocytes / Q000276:immunology*; D000328:Adult; D000906:Antibodies / Q000032:analysis*; D001369:Axons / Q000473:pathology*; D002819:Chorea / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D005677:G(M1) Ganglioside / Q000276:immunology*; D006801:Humans; D008297:Male; D009468:Neuromuscular Diseases / Q000276:immunology* / Q000473:pathology
D000906:Antibodies; D005677:G(M1) Ganglioside