The germinal center kinase gene and a novel CDC25-like gene are located in the vicinity of the PYGM gene on 11q13.
Multiple endocrine neoplasia type 1 (MEN1) is tightly linked to the muscle-type glycogen phosphorylase (PYGM) gene in 11q13. This region of the human genome contains additional disease-related loci implicated in the development of insulin-dependent diabetes mellitus, familial paraganglioma type 2, spinocerebellar ataxia type 5, Bardet-Biedl syndrome and translocation t(11;17) described in B-cell non-Hodgkin's lymphoma. We approached cloning of candidate disease genes from 11q13 by large-scale genomic sequencing. We obtained > 106 kb of sequence around the PYGM gene and established a transcriptional map that includes: (i) two genes previously localized to 11q13, PYGM and a zinc-finger protein (ZFM1) gene; (ii) the germinal center kinase (GCK, human B-lymphocyte serine/threonine protein kinase) gene; (iii) a novel human CDC25-like (HCDC25L) gene; (iv) a dystrophia myotonica protein kinase-like (DMPKL) gene; and (v) a novel ubiquitously expressed gene of unknown function (germinal center kinase- neighboring gene, GCKNG).
Kedra
D
D
Department of Molecular Medicine, Karolinska Hospital, Stockholm, Sweden.
Seroussi
E
E
Fransson
I
I
Trifunovic
J
J
Clark
M
M
Lagercrantz
J
J
Blennow
E
E
Mehlin
H
H
Dumanski
J
J
D000595:Amino Acid Sequence; D002352:Carrier Proteins / Q000235:genetics; D018797:Cell Cycle Proteins / Q000235:genetics*; D002874:Chromosome Mapping; D002880:Chromosomes, Human, Pair 11 / Q000235:genetics*; D003001:Cloning, Molecular / Q000379:methods; D004268:DNA-Binding Proteins; D005091:Exons / Q000235:genetics; D005796:Genes / Q000235:genetics; D000081410:Germinal Center Kinases; D006801:Humans; D007438:Introns / Q000235:genetics; D008969:Molecular Sequence Data; D018761:Multiple Endocrine Neoplasia Type 1 / Q000235:genetics; D009132:Muscles / Q000201:enzymology; D009223:Myotonic Dystrophy; D065636:Myotonin-Protein Kinase; D009687:Nuclear Proteins / Q000235:genetics; D010749:Phosphoprotein Phosphatases / Q000235:genetics*; D006005:Phosphorylases / Q000235:genetics*; D017346:Protein Serine-Threonine Kinases / Q000235:genetics*; D000072260:RNA Splicing Factors; D012333:RNA, Messenger / Q000032:analysis; D017422:Sequence Analysis, DNA; D017386:Sequence Homology, Amino Acid; D014157:Transcription Factors; D020666:ras-GRF1
D002352:Carrier Proteins; D018797:Cell Cycle Proteins; C585517:DMPK protein, human; D004268:DNA-Binding Proteins; D000081410:Germinal Center Kinases; D009687:Nuclear Proteins; D000072260:RNA Splicing Factors; D012333:RNA, Messenger; C107467:SF1 protein, human; D014157:Transcription Factors; D020666:ras-GRF1; D006005:Phosphorylases; C105518:CDC42BPA protein, human; D065636:Myotonin-Protein Kinase; D017346:Protein Serine-Threonine Kinases; D010749:Phosphoprotein Phosphatases