title: The nature of generalized anxiety disorder and pathological worry: current evidence and conceptual models.
abstract: OBJECTIVE
  To examine the nature and conceptualization of generalized anxiety disorder (GAD) and chronic worry as well as data bearing on the validity of GAD as a distinct diagnosis.
  
  
  METHODS
  Narrative literature review.
  
  
  RESULTS
  Although a wealth of data have been obtained on the epidemiology, genetics, and nature of GAD, many important questions remain regarding the validity of current conceptual models of pathological worry and the discriminability of GAD from certain emotional disorders (for instance, mood disorders) and higher-order trait vulnerability dimensions (for example, negative affect).
  
  
  CONCLUSIONS
  Because the constituent features of GAD are salient to current conceptual models of emotional disorders (for example, models that implicate negative affect or worry/anxious apprehension as vulnerability factors), research on the nature of GAD and its associated features should provide important information on the pathogenesis, course, and co-occurrence of the entire range of anxiety and mood disorders.
authors.affiliation: Center for Anxiety and Related Disorders, Boston University, MA 02215-2015, USA.
authors.forename: T A
authors.initials: TA
authors.lastname: Brown
mesh_terms: D001007:Anxiety / Q000145:classification / Q000175:diagnosis* / Q000523:psychology; D001008:Anxiety Disorders / Q000145:classification / Q000175:diagnosis* / Q000523:psychology; D006801:Humans; D011569:Psychiatric Status Rating Scales; D011599:Psychopathology