Improved cardiac iodine-123 metaiodobenzylguanidine accumulation after drug therapy in a patient with Parkinson's disease.
A 72-year-old woman with Parkinson's disease and autonomic dysfunction underwent I-123 MIBG cardiac imaging to study sympathetic neuronal integrity. This revealed a defect in the infero-posterior wall. Tc-99m sestamibi myocardial perfusion imaging revealed no abnormalities. On follow-up I-123 MIBG SPECT, the defect was less prominent and the parkinsonian symptoms were ameliorated by drug therapy. Cardiac I-123 MIBG imaging may be a promising new method for evaluating drug therapy in patients with Parkinson's disease.
Kanzaki
N
N
Department of Radiology, National Minami Okayama Hospital, Japan.
Sato
K
K
Hayabara
T
T
D019797:3-Iodobenzylguanidine; D000368:Aged; D000978:Antiparkinson Agents / Q000627:therapeutic use*; D001342:Autonomic Nervous System Diseases / Q000000981:diagnostic imaging; D003326:Coronary Circulation; D015103:Droxidopa / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D015637:Gated Blood-Pool Imaging; D006321:Heart / Q000000981:diagnostic imaging*; D006331:Heart Diseases / Q000000981:diagnostic imaging; D006801:Humans; D007457:Iodine Radioisotopes; D010300:Parkinson Disease / Q000188:drug therapy*; D010479:Pergolide / Q000627:therapeutic use; D019275:Radiopharmaceuticals; D013318:Stroke Volume; D013564:Sympathetic Nervous System / Q000000981:diagnostic imaging; D017256:Technetium Tc 99m Sestamibi; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods
D000978:Antiparkinson Agents; D007457:Iodine Radioisotopes; D019275:Radiopharmaceuticals; D010479:Pergolide; D019797:3-Iodobenzylguanidine; D017256:Technetium Tc 99m Sestamibi; D015103:Droxidopa