Kaposi's sarcoma-associated herpesvirus (KSHV)/human herpesvirus 8 (HHV8)--a new human tumour virus.
Recently, a novel DNA virus has been molecularly cloned from Kaposi's sarcoma (KS) tissue, a tumour common in acquired immune deficiency syndrome (AIDS). Analysis of the viral genome confirms that it is a relative of human herpesviruses and the virus has been designated HHV-8. Epidemiological evidence suggests a strong aetiological link between the presence of HHV-8 DNA and/or antibodies against the virus, and KS. Additional sequence analysis suggests that the HHV-8 genome contains sequences which encode a D type cyclin and a number of other genes potentially implicated in growth deregulation which may be relevant to its proposed role as a transforming virus.
Brooks
L A
LA
Department of Clinical Sciences, London School of Hygiene and Tropical Medicine, U.K.
Wilson
A J
AJ
Crook
T
T
D017088:AIDS-Related Opportunistic Infections / Q000150:complications*; D016679:Genome, Viral; D006678:HIV; D006566:Herpesviridae Infections / Q000150:complications*; D019288:Herpesvirus 8, Human / Q000235:genetics*; D006801:Humans; D016483:Lymphoma, AIDS-Related / Q000209:etiology / Q000821:virology; D016133:Polymerase Chain Reaction; D012514:Sarcoma, Kaposi / Q000209:etiology / Q000821:virology*; D012878:Skin Neoplasms / Q000209:etiology / Q000821:virology*