title: Echocardiographic assessment of cardiac involvement in systemic AL amyloidosis in relation to whole body amyloid load measured by serum amyloid P component (SAP) clearance.
abstract: The severity of cardiac infiltration in AL amyloidosis is unrelated to whole body amyloid load as measured by serum amyloid P (SAP) tracer studies. Radiolabeled SAP and echocardiography permit identification of patients with severe cardiac disease with a low whole body load who may be the best candidates for transplantation.
authors.affiliation: Department of Medicine, Hammersmith Hospital, London, United Kingdom.
authors.forename: G J
authors.initials: GJ
authors.lastname: Clesham
authors.forename: D M
authors.initials: DM
authors.lastname: Vigushin
authors.forename: P N
authors.initials: PN
authors.lastname: Hawkins
authors.forename: M B
authors.initials: MB
authors.lastname: Pepys
authors.forename: C M
authors.initials: CM
authors.lastname: Oakley
authors.forename: P
authors.initials: P
authors.lastname: Nihoyannopoulos
mesh_terms: D000328:Adult; D000368:Aged; D000682:Amyloid / Q000378:metabolism*; D000686:Amyloidosis / Q000503:physiopathology*; D009202:Cardiomyopathies / Q000473:pathology / Q000503:physiopathology*; D015150:Echocardiography, Doppler; D005260:Female; D006352:Heart Ventricles / Q000473:pathology; D006801:Humans; D007457:Iodine Radioisotopes; D008297:Male; D008875:Middle Aged; D000683:Serum Amyloid P-Component / Q000493:pharmacokinetics*; D013997:Time Factors; D016277:Ventricular Function, Left / Q000187:drug effects
chemical_list: D000682:Amyloid; D007457:Iodine Radioisotopes; D000683:Serum Amyloid P-Component; C035222:amyloid protein AL