Nocturnal fall in blood pressure in the elderly is related to presence of hypertension and not age.
OBJECTIVE
To determine whether the reduced nocturnal fall in blood pressure (BP) reported in elderly hypertensives is due to ageing or to the presence of hypertension.


METHODS
Twenty-four hour ambulatory BP recordings of 68 normotensive elderly were compared with those of 55 elderly treated hypertensives, aged 63-88 years. Mean night-time BPs were calculated from the average of readings during sleep and mean daytime BPs from the remaining recordings. The maximum day-night BP differences were calculated. Plasma renin, aldosterone and noradrenaline were measured.


RESULTS
Normotensive subjects were aged 72.0 +/- 4.7 years and treated hypertensives 73.7 +/- 4.9 years (p = 0.049). Normotensives had lower systolic BP (SBP) than hypertensives (125 +/- 12 mmHg versus 135 +/- 14 mmHg, p < 0.01). The fall in SPB at night was greater in normotensives than in hypertensives (18 +/- 9 versus 14 +/- 9 mmHg, p < 0.02). Non-dipping occurred in 24% of all subjects, with 59% of these being hypertensives. The nocturnal fall in SBP was not related to age (beta = -0.04, p < 0.62) but was inversely related to a history of hypertension (chi (2) = 5.82, p = 0.02). Serum noradrenaline was significantly related to nocturnal SBP fall (beta = 0.28, p = 0.01).


CONCLUSIONS
Elderly normotensives have a greater decline in nocturnal SBP than treated elderly hypertensives. The failure of SBP to fall at night appears to be more a feature of hypertension than of ageing. Early morning noradrenaline estimations are higher in patients with a greater nocturnal blood pressure fall.
Morfis
L
L
Department of Aged Care, UNSW, St George Hospital, Kogarah, Australia.
Howes
L G
LG
D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D001794:Blood Pressure / Q000502:physiology*; D018660:Blood Pressure Monitoring, Ambulatory; D002940:Circadian Rhythm / Q000502:physiology*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000503:physiopathology*; D008297:Male; D009638:Norepinephrine / Q000097:blood
D009638:Norepinephrine