Multisubstrate analogue based on 5,8,10-trideazafolate.
Boger
D L
DL
Department of Chemistry, Scripps Research Institute, La Jolla, CA 92037, USA.
Haynes
N E
NE
Warren
M S
MS
Ramcharan
J
J
Kitos
P A
PA
Benkovic
S J
SJ
D002455:Cell Division / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry* / Q000378:metabolism; D005971:Glutamates / Q000138:chemical synthesis* / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D019877:Hydroxymethyl and Formyl Transferases / Q000037:antagonists & inhibitors; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D051027:Phosphoribosylaminoimidazolecarboxamide Formyltransferase; D051026:Phosphoribosylglycinamide Formyltransferase; D011799:Quinazolines / Q000138:chemical synthesis* / Q000737:chemistry* / Q000378:metabolism; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013379:Substrate Specificity; D014407:Tumor Cells, Cultured
D004791:Enzyme Inhibitors; D005971:Glutamates; C109265:N-(4-(3-(2-amino-3,4-dihydro-4-oxoquinazol-6-yl)-((8-phosphono)-1-(octanoyloxy))prop-2-yl)benzoyl)glutamic acid; D011799:Quinazolines; D019877:Hydroxymethyl and Formyl Transferases; D051026:Phosphoribosylglycinamide Formyltransferase; D051027:Phosphoribosylaminoimidazolecarboxamide Formyltransferase