Structure of the receptor binding fragment HC of tetanus neurotoxin.
The 2.7 A structure of the tetanus neurotoxin receptor binding fragment Hc reveals a jelly-roll domain and a beta-trefoil domain. Hc retains the unique transport properties of the holotoxin and is capable of eliciting a protective immunological response against the full length holotoxin.
Umland
T C
TC
Wingert
L M
LM
Swaminathan
S
S
Furey
W F
WF
Schmidt
J J
JJ
Sax
M
M
D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D003198:Computer Simulation; D018360:Crystallography, X-Ray; D008565:Membrane Proteins / Q000737:chemistry* / Q000378:metabolism; D008958:Models, Molecular; D008961:Models, Structural; D008969:Molecular Sequence Data; D009474:Neurons / Q000378:metabolism; D010446:Peptide Fragments / Q000737:chemistry / Q000276:immunology; D017433:Protein Structure, Secondary; D017384:Sequence Deletion; D012984:Software; D013744:Tetanus Toxin / Q000737:chemistry* / Q000276:immunology
D008565:Membrane Proteins; D010446:Peptide Fragments; D013744:Tetanus Toxin; C028728:tetanus toxin receptor