Concomitant administration of sodium dichloroacetate and vitamin B1 for lactic acidemia in children with MELAS syndrome.
Myoclonic seizures, intractable abdominal pain, and headaches resolved during the concomitant administration of sodium dichloroacetate and vita min B1 in two Japanese siblings with the MELAS syndrome (mitochondrial myopathy, encephalopathy, lactic acidosis and strokelike syndrome).
Kuroda
Y
Y
Department of Pediatrics, School of Medicine, University of Tokushima, Japan.
Ito
M
M
Naito
E
E
Yokota
I
I
Matsuda
J
J
Saijo
T
T
Kondo
S
S
Yoneda
Y
Y
Miyazaki
M
M
Mori
K
K
Iwamoto
H
H
D000140:Acidosis, Lactic / Q000097:blood / Q000188:drug therapy* / Q000209:etiology*; D000284:Administration, Oral; D002648:Child; D003999:Dichloroacetic Acid / Q000097:blood / Q000627:therapeutic use*; D016903:Drug Monitoring; D004359:Drug Therapy, Combination; D006801:Humans; D017241:MELAS Syndrome / Q000150:complications*; D008297:Male; D012720:Severity of Illness Index; D013831:Thiamine / Q000627:therapeutic use*
D003999:Dichloroacetic Acid; D013831:Thiamine