title: Linell classification of breast cancer morphology compared to histologic grading, S-phase fraction and DNA-ploidy.
abstract: One hundred and fifty-eight histologically verified mammary carcinomas with known mammographic doubling time (DT) were studied with special emphasis on a morphologic classification proposed by Linell et al. [8, 12, 14, 15]. The hypothesis that Linell classification of ductal carcinomas into comedo, tubuloductal and tubular carcinomas is easy to perform with small inter-observer variations, was not fully confirmed. The Linell classification was found to correlate well with conventional WHO malignancy grading, S-phase fraction and DNA-ploidy. The Linell classification also correlated to surgical stage, lymph node status and DT, but not at all to tumour size. Using distant disease-free survival as an endpoint, the Linell classification gave prognostic information comparable to conventional histologic grading, seeming to be a simple, cheap and reliable method well worth trying on a larger scale.
authors.affiliation: Department of Surgery, University of Umeå, Sweden.
authors.forename: J
authors.initials: J
authors.lastname: Söderström
authors.forename: C
authors.initials: C
authors.lastname: Arnerlöv
authors.forename: S O
authors.initials: SO
authors.lastname: Emdin
authors.forename: B
authors.initials: B
authors.lastname: Lundgren
authors.forename: G
authors.initials: G
authors.lastname: Roos
authors.forename: L
authors.initials: L
authors.lastname: Bjersing
authors.forename: C
authors.initials: C
authors.lastname: Norberg
authors.forename: K A
authors.initials: KA
authors.lastname: Angquist
mesh_terms: D000230:Adenocarcinoma / Q000145:classification* / Q000235:genetics / Q000473:pathology; D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000145:classification* / Q000235:genetics / Q000473:pathology*; D018270:Carcinoma, Ductal, Breast / Q000145:classification* / Q000235:genetics / Q000473:pathology; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000145:classification* / Q000235:genetics / Q000473:pathology; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D011003:Ploidies; D016196:S Phase