Atypical lymphoid infiltrates arising in cutaneous lesions of connective tissue disease.
Atypical lymphoid infiltrates occurring in the setting of connective-tissue disease (CTD) comprise malignant neoplasms of B-cell or T-cell phenotypes and various reactive lymphoid hyperplasias, such as myoepithelial sialadenitis, lymphocytic thyroiditis, and lymphocytic interstitial pneumonitis. We describe 17 patients with atypical lymphoid infiltrates arising in cutaneous lesions of CTD, the spectrum of which included lupus erythematosus, dermatomyositis, relapsing polychondritis, and lichen sclerosus et atrophicus. There were two principal categories, pseudolymphoma and malignant lymphoma, the former representing 15 of the 17 cases. The clinical and histologic features and possible pathogenetic mechanisms are discussed.
Magro
C M
CM
Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School Pathology Services, Inc., Cambridge, Massachusetts, USA.
Crowson
A N
AN
Harrist
T J
TJ
D000328:Adult; D000368:Aged; D001402:B-Lymphocytes / Q000473:pathology; D003240:Connective Tissue Diseases / Q000473:pathology*; D003882:Dermatomyositis / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D018459:Lichen Sclerosus et Atrophicus / Q000473:pathology; D017563:Lung Diseases, Interstitial / Q000473:pathology; D008178:Lupus Erythematosus, Cutaneous / Q000473:pathology; D008179:Lupus Erythematosus, Discoid / Q000473:pathology; D008180:Lupus Erythematosus, Systemic / Q000473:pathology; D008214:Lymphocytes / Q000473:pathology*; D008223:Lymphoma / Q000473:pathology; D016410:Lymphoma, T-Cell, Cutaneous / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D011081:Polychondritis, Relapsing / Q000473:pathology; D019310:Pseudolymphoma / Q000473:pathology; D012793:Sialadenitis / Q000473:pathology; D012871:Skin Diseases / Q000473:pathology*; D012878:Skin Neoplasms / Q000473:pathology; D013601:T-Lymphocytes / Q000473:pathology; D013967:Thyroiditis, Autoimmune / Q000473:pathology