A region of allelic imbalance in 1q31-32 in primary breast cancer coincides with a recombination hot spot.
Previous studies have shown that the 1q31-32 region frequently presents allelic imbalance (AI) in various neoplastic diseases, such as breast cancer, medulloblastoma, male germ cell tumors, and renal collecting duct carcinoma, suggesting the presence of a tumor suppressor gene in this location. We used 19 informative microsatellite markers to analyze 33 primary breast tumors for AI in the 1q31-32 region. Our results demonstrate a 10-cM critical region of AI that is present in more than 60% of the tumors. This region is located proximal to the REN locus and is flanked by the CACNL1A3 and D1S2655 markers. Most important, the critical region of AI coincides with a female hot spot of recombination, suggesting a possible correlation between the two regions.
Benítez
J
J
Departamento Genética, Fundación Jimenez Díaz, Madrid, Spain. fjdvgenetica@jet.es
Osorio
A
A
Barroso
A
A
Arranz
E
E
Díaz-Guillén
M A
MA
Robledo
M
M
Rodríguez de Córdoba
S
S
Heine-Suñer
D
D
D000483:Alleles; D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology; D018270:Carcinoma, Ductal, Breast / Q000235:genetics; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics*; D018450:Disease Progression; D005260:Female; D016147:Genes, Tumor Suppressor; D005819:Genetic Markers; D006801:Humans; D019656:Loss of Heterozygosity; D008297:Male; D018895:Microsatellite Repeats; D011995:Recombination, Genetic; D012727:Sex Characteristics
D005819:Genetic Markers