title: Rationale and clinical status of local hyperthermia, radiation, and chemotherapy in locally advanced malignancies.
abstract: The combination of ionizing irradiation and local hyperthermia therapy has been demonstrated to be efficacious in a variety of localized neoplasms. One of the most consistent conclusions from this experience, however, is the finding that large tumor size is a significant negative prognosticator for attaining complete tumor regression. During the past decade investigators have begun to look at the possibility of adding chemotherapy to thermo-radiotherapy in order to improve the efficacy of treatment in patients with large tumors. This review article summarizes the recent clinical experience with such triple modality therapy.
authors.affiliation: Medical University of Lübeck, Germany.
authors.forename: T
authors.initials: T
authors.lastname: Feyerabend
authors.forename: R
authors.initials: R
authors.lastname: Steeves
authors.forename: G J
authors.initials: GJ
authors.lastname: Wiedemann
authors.forename: E
authors.initials: E
authors.lastname: Richter
authors.forename: H I
authors.initials: HI
authors.lastname: Robins
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D003131:Combined Modality Therapy; D006801:Humans; D006979:Hyperthermia, Induced; D009369:Neoplasms / Q000628:therapy*
chemical_list: D000970:Antineoplastic Agents