Regulation of ion transport by protein-protein interaction domains.
Protein-protein interaction via specific modular domains has been implicated in the regulation of many signalling pathways. Recently, such modules, in particular WW, Src homology-3 and PDZ domains, have been shown to regulate localization, clustering and function of several ion channels and transporters, including the epithelial Na+ channel, K+ channel and ionotropic neurotransmitter receptors.
Staub
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Hospital for Sick Children, Division of Respiratory Research, Toronto, Ontario, Canada.
Rotin
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D000595:Amino Acid Sequence; D000818:Animals; D006801:Humans; D007473:Ion Channels / Q000378:metabolism*; D017136:Ion Transport; D008969:Molecular Sequence Data; D011485:Protein Binding; D011506:Proteins / Q000737:chemistry / Q000378:metabolism*
D007473:Ion Channels; D011506:Proteins