title: A verrucous lesion on skin grafted after necrotizing fasciitis in a diabetic patient successfully treated with combined topical 5-FU and tacalcitol.
abstract: Many complications of diabetes mellitus involve the feet. These include infections, neuropathy, vasculopathy, and poor wound healing. Neuropathy causes chronic pressure or friction on an area of sensory loss and occasionally causes verrucous skin lesions. We describe a diabetic patient, complicated by necrotizing fasciitis, who developed a verrucous skin lesion on a skin graft site. The verrucous skin lesion was treated successfully with combined topical 5-fluorouracil and vitamin D3 application.
authors.affiliation: Department of Dermatology, Asahikawa Medical College, Hokkaido, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Sakai
authors.forename: Y
authors.initials: Y
authors.lastname: Fukami
authors.forename: M
authors.initials: M
authors.lastname: Ibe
authors.forename: T
authors.initials: T
authors.lastname: Tamura
authors.forename: Y
authors.initials: Y
authors.lastname: Hashimoto
authors.forename: H
authors.initials: H
authors.lastname: Iizuka
mesh_terms: D000287:Administration, Topical; D017719:Diabetic Foot / Q000150:complications / Q000601:surgery*; D004100:Dihydroxycholecalciferols / Q000008:administration & dosage; D004359:Drug Therapy, Combination; D019115:Fasciitis, Necrotizing / Q000150:complications / Q000601:surgery*; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D008297:Male; D008875:Middle Aged; D016038:Skin Transplantation / Q000009:adverse effects*; D014860:Warts / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology
chemical_list: D004100:Dihydroxycholecalciferols; C023850:1 alpha,24-dihydroxyvitamin D3; D005472:Fluorouracil