title: Chronic granulomatous disease masquerading as a bladder tumor: a potential source of diagnostic error.
abstract: Chronic granulomatous disease (CGD) is a rare inherited disease of childhood, characterized by recurrent bacterial or fungal infections. The underlying defect is a dysfunction of neutrophil granulocytes interfering with their ability to kill phagocytosed microorganisms. Genitourinary tract involvement has been reported in 38% of these patients. We report a case of CGD in whom the most important findings were urinary bladder tumors at different locations and a subsequent obstruction of the left ureter. A review of the pathogenesis of the disease, potential involvement of the urinary tract and treatment is presented.
authors.affiliation: Department of Urology, School of Medicine, Heinrich Heine University, Düsseldorf, Germany.
authors.forename: M L
authors.initials: ML
authors.lastname: Bendhack
authors.forename: T
authors.initials: T
authors.lastname: Vögeli
authors.forename: H
authors.initials: H
authors.lastname: Schroten
authors.forename: C D
authors.initials: CD
authors.lastname: Gerharz
authors.forename: R
authors.initials: R
authors.lastname: Ackermann
mesh_terms: D000328:Adult; D003558:Cystoscopy; D003937:Diagnosis, Differential; D006105:Granulomatous Disease, Chronic / Q000150:complications / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D006869:Hydronephrosis / Q000209:etiology; D008279:Magnetic Resonance Imaging; D008297:Male; D009092:Mucous Membrane / Q000473:pathology; D011127:Polyps / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D014463:Ultrasonography; D014513:Ureter / Q000473:pathology; D001749:Urinary Bladder Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology