Sibling allogeneic bone marrow transplantation in a patient with type I Glanzmann's thrombasthenia.
Glanzmann's thrombasthenia is a rare inherited bleeding disorder caused by either quantitative or qualitative abnormalities of the platelet membrane glycoprotein (Gp) IIb/IIIa complex. Bleeding is usually mucocutaneous in origin and may be of a severe nature. We report the use of allegeneic bone marrow transplantation in a 5-year-old child with homozygous type I Glanzmann's thrombasthenia, using the patient's younger brother as marrow donor. Engraftment was successful and has resulted in a resolution of bleeding episodes. We conclude that allogeneic BMT is a potentially curative option for those with Glanzmann's thrombasthenia associated with severe bleeding symptoms.
McColl
M D
MD
Department of Haematology, Royal Hospital for Sick Children, Yorkhill, Glasgow.
Gibson
B E
BE
D016026:Bone Marrow Transplantation / Q000379:methods*; D002675:Child, Preschool; D006801:Humans; D008297:Male; D010980:Platelet Membrane Glycoproteins / Q000032:analysis; D013915:Thrombasthenia / Q000097:blood / Q000628:therapy*; D014184:Transplantation, Homologous
D010980:Platelet Membrane Glycoproteins