Activity and tissue localization of cathepsin G in non small cell lung cancer.
Activity and tissue localization of cathepsin G were examined in tumors deriving from 73 patients with non small cell lung cancer. Activity of cathepsin G was highest in adenocarcinoma, lower in planoepitheliale cancer, the lowest in macrocellular cancer. In all histological types of tumors cathepsin G activity in supernatants was lower than in sediments. The enzyme immunohistochemically was localized in neutrophils. There is evident correlation between neutrophil numbers and cathepsin G activity in examined cancer types. Result of our examinations indicate a relationship between cathepsin G activity, grade of tumor differentiation and particular clinical stages of disease.
Maksimowicz
T
T
Department of Instrumental Analysis, Medical Academy of Białystok.
Chyczewska
E
E
Chyczewski
L
L
Nikliński
J
J
Ostrowska
H
H
Szyszko
J
J
Furman
M
M
D000230:Adenocarcinoma / Q000201:enzymology / Q000473:pathology / Q000648:ultrastructure; D000328:Adult; D000368:Aged; D018287:Carcinoma, Large Cell / Q000201:enzymology / Q000473:pathology / Q000648:ultrastructure; D002289:Carcinoma, Non-Small-Cell Lung / Q000201:enzymology* / Q000473:pathology / Q000648:ultrastructure; D002294:Carcinoma, Squamous Cell / Q000201:enzymology / Q000473:pathology / Q000648:ultrastructure; D056649:Cathepsin G; D002403:Cathepsins / Q000032:analysis*; D002454:Cell Differentiation; D002458:Cell Fractionation; D005260:Female; D006801:Humans; D008168:Lung / Q000201:enzymology; D008175:Lung Neoplasms / Q000201:enzymology* / Q000473:pathology / Q000648:ultrastructure; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000032:analysis*; D009367:Neoplasm Staging; D009504:Neutrophils / Q000201:enzymology*; D012697:Serine Endopeptidases; D012995:Solubility
D009363:Neoplasm Proteins; D002403:Cathepsins; D012697:Serine Endopeptidases; C534094:CTSG protein, human; D056649:Cathepsin G