title: Chorea-acanthocytosis with polyclonal antibodies to ganglioside GM1.
abstract: A patient with chorea-acanthocytosis presenting with axonal neuropathy showed an elevation in IgM polyclonal antibodies to the GM1 ganglioside, which were estimated by enzyme-linked immunosorbent assay and complement-mediated liposome immune lysis assay (LILA). This is the first demonstration of such antibodies in chorea-acanthocytosis. Anti-GM1 antibodies might have directly caused the axonal neuropathy by binding to GM1 or cross-reactive antigens in the nerves.
authors.affiliation: Second Department of Internal Medicine, Fukui Medical School, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Hirayama
authors.forename: T
authors.initials: T
authors.lastname: Hamano
authors.forename: M
authors.initials: M
authors.lastname: Shiratori
authors.forename: T
authors.initials: T
authors.lastname: Mutoh
authors.forename: T
authors.initials: T
authors.lastname: Kumano
authors.forename: T
authors.initials: T
authors.lastname: Aita
authors.forename: M
authors.initials: M
authors.lastname: Kuriyama
mesh_terms: D000050:Acanthocytes / Q000276:immunology*; D000328:Adult; D000906:Antibodies / Q000032:analysis*; D001369:Axons / Q000473:pathology*; D002819:Chorea / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D005677:G(M1) Ganglioside / Q000276:immunology*; D006801:Humans; D008297:Male; D009468:Neuromuscular Diseases / Q000276:immunology* / Q000473:pathology
chemical_list: D000906:Antibodies; D005677:G(M1) Ganglioside