title: Comparison of peak serum C-reactive protein and hydroxybutyrate dehydrogenase levels in patients with acute myocardial infarction treated with alteplase and streptokinase.
abstract: Peak serum C-reactive protein concentrations were measured in 146 patients randomized to receive streptokinase, alteplase, or a combination of streptokinase and alteplase in the GUSTO-I trial. Those receiving alteplase treatment had lower values than those receiving streptokinase or the combination treatment. Irrespective of treatment, complete reperfusion of the infarct-related artery (TIMI grade 3 flow) was associated with low peak serum C-reactive protein values.
authors.affiliation: Clinic of Internal Medicine, Department of Clinical Sciences, Tampere University, Finland.
authors.forename: K
authors.initials: K
authors.lastname: Pietilä
authors.forename: W T
authors.initials: WT
authors.lastname: Hermens
authors.forename: A
authors.initials: A
authors.lastname: Harmoinen
authors.forename: T
authors.initials: T
authors.lastname: Baardman
authors.forename: A
authors.initials: A
authors.lastname: Pasternack
authors.forename: E J
authors.initials: EJ
authors.lastname: Topol
authors.forename: M L
authors.initials: ML
authors.lastname: Simoons
mesh_terms: D000368:Aged; D002097:C-Reactive Protein / Q000378:metabolism*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D006884:Hydroxybutyrate Dehydrogenase / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000188:drug therapy; D013300:Streptokinase / Q000627:therapeutic use*; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use*
chemical_list: D002097:C-Reactive Protein; D006884:Hydroxybutyrate Dehydrogenase; D013300:Streptokinase; D010959:Tissue Plasminogen Activator