title: Mycobacterium chelonae keratitis after excimer laser photorefractive keratectomy.
abstract: This is the first report of a severe case of Mycobacterium chelonae keratitis; it occurred in a 26-year-old man after he had undergone excimer laser photorefractive keratectomy for the correction of severe myopia, once the epithelium was already healed. The diagnosis was made by culture results and acid-fast staining of corneal scrapings. Topical ciprofloxacin sodium, 0.3 mg/mL, plus amikacin sodium, 10 mg/mL, and oral clarithromycin sodium led to remission of the ulceration after 3 months of therapy. Subsequent topical corticosteroid therapy led to complete visual recovery during 1 year of follow-up. There may be an increased risk of severe keratitis during the first postoperative months in eyes that have already undergone photorefractive keratectomy, due to the presence of some microepithelial defects symptomatically negative and not easily detectable by slit-lamp examination.
authors.affiliation: Department of Ophthalmology and Visual Sciences, Scientific Institute San Raffaele Hospital, University of Milan, Italy. r.brancato@ophthalm.hsr.it
authors.forename: R
authors.initials: R
authors.lastname: Brancato
authors.forename: F
authors.initials: F
authors.lastname: Carones
authors.forename: E
authors.initials: E
authors.lastname: Venturi
authors.forename: A
authors.initials: A
authors.lastname: Cavallero
authors.forename: G
authors.initials: G
authors.lastname: Gesu
mesh_terms: D000328:Adult; D000583:Amikacin / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002939:Ciprofloxacin / Q000627:therapeutic use; D017291:Clarithromycin / Q000627:therapeutic use; D003315:Cornea / Q000382:microbiology* / Q000473:pathology / Q000601:surgery; D003320:Corneal Ulcer / Q000188:drug therapy / Q000382:microbiology* / Q000473:pathology; D015818:Eye Infections, Bacterial / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D005500:Follow-Up Studies; D006801:Humans; D054018:Lasers, Excimer; D008297:Male; D009165:Mycobacterium Infections, Nontuberculous / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D016926:Mycobacterium chelonae / Q000302:isolation & purification*; D009216:Myopia / Q000601:surgery; D018903:Photorefractive Keratectomy / Q000009:adverse effects*; D011183:Postoperative Complications; D014792:Visual Acuity; D014945:Wound Healing
chemical_list: D000900:Anti-Bacterial Agents; D002939:Ciprofloxacin; D000583:Amikacin; D017291:Clarithromycin