title: ApoE genotype and Alzheimer's disease in adults with Down syndrome: meta-analysis.
abstract: The apoE gene polymorphism was examined in 100 adults with Down syndrome (with and without dementia) compared to 346 control subjects without mental retardation. Meta-analysis of available data (480 subjects) revealed that apolipoprotein E genotype distribution for people with Down syndrome was similar to that of the nonretarded population. Although no significant association between possession of the apoE epsilon 4 allele and onset of Alzheimer's disease was found, subjects with the allele had a tendency towards lower age of onset of dementia. Subjects with apoE epsilon 2 allele may not develop dementia and may have increased longevity.
authors.affiliation: University of Birmingham, Queen Elizabeth Hospital, Birmingham, United Kingdom.
authors.forename: V P
authors.initials: VP
authors.lastname: Prasher
authors.forename: T A
authors.initials: TA
authors.lastname: Chowdhury
authors.forename: B R
authors.initials: BR
authors.lastname: Rowe
authors.forename: S C
authors.initials: SC
authors.lastname: Bain
mesh_terms: D000328:Adult; D000368:Aged; D000483:Alleles; D000544:Alzheimer Disease / Q000150:complications* / Q000235:genetics*; D001057:Apolipoproteins E / Q000235:genetics*; D004314:Down Syndrome / Q000150:complications*; D005260:Female; D005838:Genotype; D006801:Humans; D008136:Longevity; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic
chemical_list: D001057:Apolipoproteins E