Benzoquinones inhibit the expression of inducible nitric oxide synthase gene.
Benzoquinones inhibited the production of NO induced by LPS and gamma-IFN in C6 glia cells. The mechanistic studies showed that benzoquinones inhibited the expression of iNOS mRNA through inactivation of NF kappa B. Benzoquinones may be a useful candidate for the development of a drug to treat disease due to iNOS gene over-expression.
Niwa
M
M
Faculty of Pharmaceutical Sciences, The University of Tokushima, Japan. mniwa@ph.tokushima-u.ac.jp
Nakamura
N
N
Kitajima
K
K
Ueda
M
M
Tsutsumishita
Y
Y
Futaki
S
S
Takaishi
Y
Y
D000818:Animals; D016227:Benzoquinones / Q000494:pharmacology*; D015971:Gene Expression Regulation, Enzymologic / Q000187:drug effects*; D005796:Genes / Q000187:drug effects*; D009457:Neuroglia; D019001:Nitric Oxide Synthase / Q000096:biosynthesis / Q000235:genetics*; D012333:RNA, Messenger / Q000037:antagonists & inhibitors; D051381:Rats; D014407:Tumor Cells, Cultured
D016227:Benzoquinones; D012333:RNA, Messenger; D019001:Nitric Oxide Synthase