5-HT1A receptors in lithium-induced conditioned taste aversion.
Experiments were carried out using rats to investigate whether 5-HT1A neural mechanisms are involved in lithium-induced conditioned taste aversion (CTA). We found that the 5-HT1A antagonists p-MPPI and pindolol caused CTA similar to that produced by LiCl. The 5-HT1A agonist 8-OH-DPAT counteracted lithium-induced CTA. Pindolol dose-dependently abolished effects of 8-OH-DPAT on LiCl-induced CTA. These findings support the notion that lithium has antagonistic actions on 5-HT1A receptors. Inhibition of 5-HT synthesis by PCPA failed, however, to prevent lithium-induced CTA. Evidently, mechanisms other than those governed solely by 5-HT are also involved in lithium-induced CTA.
Wegener
G
G
Department of Biological Psychiatry, Psychiatric Hospital, Aarhus University, Risskov, Denmark.
Smith
D F
DF
Rosenberg
R
R
D017371:8-Hydroxy-2-(di-n-propylamino)tetralin / Q000494:pharmacology; D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D005247:Feeding Behavior / Q000187:drug effects*; D008094:Lithium / Q000494:pharmacology*; D008297:Male; D010869:Pindolol / Q000494:pharmacology; D051381:Rats; D011985:Receptors, Serotonin / Q000187:drug effects / Q000502:physiology*; D044263:Receptors, Serotonin, 5-HT1; D012439:Saccharin; D013649:Taste
D011985:Receptors, Serotonin; D044263:Receptors, Serotonin, 5-HT1; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; D008094:Lithium; D010869:Pindolol; D012439:Saccharin