title: Synthesis of L-ribofuranosyl C-nucleosides.
abstract: C-Nucleosides, 4-amino-8-(beta-L-ribofuranosyl)pyrazolo[1, 5-a]-1,3,5-triazine (12) and 4-amino-7-(beta-L-ribofuranosyl)-5H-pyrrolo[3,2-d]pyrimidine (L-9-deazaadenosine, 22), were synthesized from the key intermediate, 3-dimethylamino-2-(2,3-O-isopropylidene-5-O-trityl-L-ribofuranosyl) acrylonitrile (8), which was prepared from L-xylose in 11 steps.
authors.affiliation: Department of Medicinal Chemistry, College of Pharmacy, University of Georgia, Athens 30602, USA.
authors.forename: C
authors.initials: C
authors.lastname: Liang
authors.forename: T
authors.initials: T
authors.lastname: Ma
authors.forename: J S
authors.initials: JS
authors.lastname: Cooperwood
authors.forename: J
authors.initials: J
authors.lastname: Du
authors.forename: C K
authors.initials: CK
authors.lastname: Chu
mesh_terms: D019380:Anti-HIV Agents / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D000998:Antiviral Agents / Q000627:therapeutic use*; D002460:Cell Line; D006509:Hepatitis B / Q000188:drug therapy; D015394:Molecular Structure; D012263:Ribonucleosides / Q000138:chemical synthesis*; D014372:Tubercidin / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: D019380:Anti-HIV Agents; D000970:Antineoplastic Agents; D000998:Antiviral Agents; C110006:L APTR; D012263:Ribonucleosides; C038031:9-deazaadenosine; D014372:Tubercidin