title: In-vitro susceptibility, tolerance and glycocalyx production in Streptococcus mutans.
abstract: We studied the presence of high-level resistance to aminoglycosides, penicillin tolerance and glycocalyx production in 160 isolates of Streptococcus mutans. Susceptibility to amoxycillin, cefazolin, imipenem, erythromycin, clindamycin, vancomycin and teicoplanin was also investigated. Of the isolates analysed, 58.8% produced glycocalyx in vitro and 2.5% were penicillin-tolerant. High-level resistance to streptomycin was found in 16.3% of the isolates, but all were sensitive to all other antibiotics tested. We found no significant relationship between glycocalyx production and high-level streptomycin resistance, penicillin tolerance or antibiotic susceptibility, except for a greater susceptibility to clindamycin and vancomycin in isolates that produced glycocalyx. Although our findings reflect the clinically favourable pattern of susceptibility currently found in this species, the appearance in some isolates of resistance, tolerance and glycocalyx production should be investigated because of the risks involved in endocarditis caused by S. mutans.
authors.affiliation: Department of Microbiology, University Hospital, University of Granada, Spain.
authors.forename: A
authors.initials: A
authors.lastname: De la Higuera
authors.forename: A
authors.initials: A
authors.lastname: Castillo
authors.forename: J
authors.initials: J
authors.lastname: Gutiérrez
authors.forename: A
authors.initials: A
authors.lastname: García-Mendoza
authors.forename: J
authors.initials: J
authors.lastname: Liébana
mesh_terms: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D004352:Drug Resistance, Microbial; D019276:Glycocalyx / Q000378:metabolism*; D006020:Glycopeptides; D018942:Macrolides; D008826:Microbial Sensitivity Tests; D010403:Penicillin Resistance; D010406:Penicillins / Q000494:pharmacology; D013295:Streptococcus mutans / Q000187:drug effects* / Q000378:metabolism
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D006020:Glycopeptides; D018942:Macrolides; D010406:Penicillins