title: Pregnancy after intracytoplasmic sperm injection with sperm from a man with a 47,XXY Klinefelter's karyotype.
abstract: OBJECTIVE
  To report the initiation of a pregnancy that was achieved by intracytoplasmic sperm injection (ICSI) with sperm from a patient with Klinefelter's syndrome.
  
  
  METHODS
  Case report.
  
  
  METHODS
  University women's hospital IVF center.
  
  
  METHODS
  A couple with primary infertility and nonmosaic 47,XXY karyotype of the male partner.
  
  
  METHODS
  Intracytoplasmic sperm injection after ovarian stimulation and transvaginal ultrasound-guided oocyte pick-up with sperm from a hypergonadotropic man with a nonmosaic 47,XXY karyotype.
  
  
  METHODS
  Clinical pregnancy.
  
  
  RESULTS
  Despite a 47,XXY karyotype in all 50 analyzed lymphocyte metaphases, the sperm of the patient led to a clinical pregnancy with the first attempt of ICSI and intrauterine transfer of three embryos. The pregnancy stopped developing in the ninth week. Cytogenetic investigation of the abortion material revealed a numerical normal 46,XXY karyotype.
  
  
  CONCLUSIONS
  Sperm from a patient with hypergonadotropic nonmosaic Klinefelter's syndrome, when used for ICSI, can lead to a pregnancy.
authors.affiliation: University of Goettingen, Germany. BHINNEY@MED.UNI-GOETTINGEN.DE
authors.forename: B
authors.initials: B
authors.lastname: Hinney
authors.forename: M
authors.initials: M
authors.lastname: Guttenbach
authors.forename: M
authors.initials: M
authors.lastname: Schmid
authors.forename: W
authors.initials: W
authors.lastname: Engel
authors.forename: H W
authors.initials: HW
authors.lastname: Michelmann
mesh_terms: D000028:Abortion, Induced; D000328:Adult; D003593:Cytoplasm; D005260:Female; D006801:Humans; D007621:Karyotyping; D007713:Klinefelter Syndrome / Q000235:genetics*; D008297:Male; D008845:Microinjections; D008846:Micromanipulation; D011247:Pregnancy; D013094:Spermatozoa