Absorption of oligodeoxynucleotide by suppository from rat rectal route.
Rectal absorption of 32-mer phosphorothioate deoxynucleotides (S-Oligo) in the rat was attempted with the aid of a suppository containing oleic acid and a surfactant. Although, the suppository without adjuvant did not show detectable blood levels, that containing over 10% oleic acid enabled the absorption of S-Oligo with tmax at 2 h postdosing.
Yoshikawa
H
H
Department of Drug Dosage Form Design, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Japan.
Gould
F
F
Takada
K
K
Seebach
S
S
D000285:Administration, Rectal; D000818:Animals; D004355:Drug Stability; D007408:Intestinal Absorption; D008297:Male; D019301:Oleic Acid; D009841:Oligonucleotides / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D010592:Pharmaceutic Aids; D051381:Rats; D017208:Rats, Wistar; D012007:Rectum / Q000378:metabolism*; D013488:Suppositories; D013873:Thionucleotides / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*
D009841:Oligonucleotides; D010592:Pharmaceutic Aids; D013488:Suppositories; D013873:Thionucleotides; D019301:Oleic Acid