Genes coding for melanoma antigens recognised by cytolytic T lymphocytes.
It is now well established that human melanoma cells express antigens that are recognised by cytolytic T lymphocytes derived from the tumour-bearing patient. The molecular definition of these antigens is progressing at an accelerated pace. The currently characterised melanoma antigens can be classified into three categories: differentiation antigens, antigens encoded by genes that are specifically expressed in tumours, and antigens encoded by mutated genes. Several of these antigens are sufficiently tumour-specific to qualify them as candidate anti-cancer vaccines in melanoma patients.
De Smet
C
C
Ludwig Institute for Cancer Research, Brussels branch, Belgium.
Lurquin
C
C
De Plaen
E
E
Brasseur
F
F
Zarour
H
H
De Backer
O
O
Coulie
P G
PG
Boon
T
T
D000941:Antigens / Q000235:genetics; D000945:Antigens, Differentiation, T-Lymphocyte / Q000235:genetics; D000951:Antigens, Neoplasm / Q000235:genetics*; D005796:Genes; D006801:Humans; D007167:Immunotherapy; D008545:Melanoma / Q000276:immunology* / Q000628:therapy; D017354:Point Mutation; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*
D000941:Antigens; D000945:Antigens, Differentiation, T-Lymphocyte; D000951:Antigens, Neoplasm