title: Cancer morbidity in workers at aluminum foundries and secondary aluminum smelters.
abstract: In a Swedish cohort of workers (n = 6,454) from seven aluminum foundries and three secondary aluminum (scrap) smelters there was no overall excess risk of cancer among male or female workers less than 85 years of age (males: 325 observed cases, standardized incidence ratio (SIR) 1.02, 95% confidence interval (CI) 0.91-1.13; females: 22 cases, SIR = 0.95, 95% CI = 0.60-1.44). In male workers, however, significantly elevated risk estimates were observed for cancer of the lung (51 cases; SIR = 1.49, 95% CI = 1.11-1.96), anorectal cancer (33 cases; SIR 2.13, 95% CI = 1.47-2.99), and sinonasal cancer (4 cases; SIR = 4.70, 95% CI = 1.28-12.01). There was no increase of urinary bladder or liver cancer. Lung cancer risks were highest in workers with a short duration of employment (< 5 years) suggesting determinants of risk related to socioeconomic factors rather than the occupational environment under study, but there were also indications of a lung cancer hazard from sand casting of aluminum for 10 years or more (SIR = 2.10, 95% CI = 1.01-3.87). The increase in anorectal cancer could not be etiologically related to occupational determinants of risk. Sand casting of aluminum aside, the cancer risk in secondary aluminum smelting seems to be lower than in primary aluminum smelting and in iron and steel founding, respectively.
authors.affiliation: Department of Occupational and Environmental Medicine, Orebro Medical Centre Hospital, Sweden. anders.selden@orebroll.se
authors.forename: A I
authors.initials: AI
authors.lastname: Seldén
authors.forename: H B
authors.initials: HB
authors.lastname: Westberg
authors.forename: O
authors.initials: O
authors.lastname: Axelson
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000395:Air Pollutants, Occupational / Q000009:adverse effects*; D000535:Aluminum / Q000009:adverse effects*; D015331:Cohort Studies; D005260:Female; D006801:Humans; D015994:Incidence; D007414:Intestinal Neoplasms / Q000453:epidemiology; D008113:Liver Neoplasms / Q000453:epidemiology; D008175:Lung Neoplasms / Q000453:epidemiology; D008297:Male; D008669:Metallurgy; D008875:Middle Aged; D009369:Neoplasms / Q000453:epidemiology*; D009664:Norway / Q000208:ethnology; D016273:Occupational Exposure / Q000009:adverse effects*; D009790:Occupations; D010255:Paranasal Sinus Neoplasms / Q000453:epidemiology; D012307:Risk Factors; D013548:Sweden / Q000453:epidemiology; D013997:Time Factors; D001749:Urinary Bladder Neoplasms / Q000453:epidemiology
chemical_list: D000395:Air Pollutants, Occupational; D000535:Aluminum