title: Soluble E-selectin and intercellular adhesion molecule-1 plasma levels increase during acute myocardial infarction.
abstract: Previous studies have shown that adhesion molecules play a crucial role in leukocyte-endothelium interactions that occur during myocardial ischemia and reperfusion. We assessed the plasma levels of the soluble form of E-selectin (sE-selectin) and intercellular adhesion molecule-1 (sICAM-1) in 15 patients with acute myocardial infarction (AMI) and in 15 controls with chronic stable angina. In patients with AMI, the levels of sE-selectin and sICAM-1 increased significantly during the first 8 h after infarction and subsequently decreased. Soluble E-selectin levels were inversely related to the peak plasma levels of creatine kinase-MB (CK-MB), and the time course of their appearance in plasma correlated with that of neutrophil count and plasma D-dimer. In individual patients, peak and mean sICAM-1 levels correlated respectively with plasma D-dimer concentrations and monocyte count, but no correlation were found when their time courses were analyzed. Eight hours after symptom onset, the mean plasma sE-selectin levels were higher in patients with AMI than in those with stable angina, whereas no significant differences were found in mean plasma sICAM-1 levels between the two groups at every time analyzed. In the acute phase of MI (a) sE-selectin and sICAM-1 levels increase during the first 8 h and subsequently decrease; (b) the increase in sE-selectin probably reflects activation of endothelial cells, correlates with other inflammatory and coagulation parameters, and is inversely related to the degree of myocardial damage; and (c) sICAM-1 plasma levels do not represent a good marker of "cell activation" because they reflect activation of different cells and may be affected by different conditions.
authors.affiliation: Laboratory of Cadiovascular Pathophysiology, Istituto Scientifico San Raffaele, Milan, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Pellegatta
authors.forename: G
authors.initials: G
authors.lastname: Pizzetti
authors.forename: Y
authors.initials: Y
authors.lastname: Lu
authors.forename: A
authors.initials: A
authors.lastname: Radaelli
authors.forename: D
authors.initials: D
authors.lastname: Pomes
authors.forename: M
authors.initials: M
authors.lastname: Carlino
authors.forename: C
authors.initials: C
authors.lastname: Meloni
authors.forename: G
authors.initials: G
authors.lastname: Belotti
authors.forename: L
authors.initials: L
authors.lastname: Galli
authors.forename: M J
authors.initials: MJ
authors.lastname: Vidal
authors.forename: S L
authors.initials: SL
authors.lastname: Chierchia
mesh_terms: D000328:Adult; D000368:Aged; D003402:Creatine Kinase / Q000097:blood*; D019040:E-Selectin / Q000097:blood*; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D007527:Isoenzymes; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood*
chemical_list: D019040:E-Selectin; D007527:Isoenzymes; D018799:Intercellular Adhesion Molecule-1; D003402:Creatine Kinase