[Suicidal poisoning with benzodiazepines].
In the period from 1987 to 1996, 103 patients with suicidal benzodiazepines poisoning were treated, including 62 women and 41 men from 16 to 79 (mean 34) years old. 23 persons were poisoned only by benzodiazepines, in 80 remaining cases intoxications were mixed eg. including benzodiazepines and alcohol, tricyclic antidepressants, barbiturates, opioids, phenothiazines. The main causes of suicides were mainly depression, drug addiction and alcoholism. Nobody died in the benzodiazepines group, while mortality rate in the group of mixed poisoning was 4%. Prescribing benzodiazepines by physicians was quite often not justified and facilitated, among others, accumulation of the dose sufficient for suicide attempt. Flumazenil was efficient for leading out from coma in 86% of cases with poisoning only by benzodiazepines and 13% of cases with mixed intoxications mainly containing benzodiazepines and alcohol or carbamazepine.
Chodorowski
Z
Z
I Kliniki Chorób Wewnetrznych I Ostrych Zatruć, Instytutu Chorób Wewnetrznych, Akademii Medycznej w Gdańsku.
Sein Anand
J
J
D000293:Adolescent; D000328:Adult; D000368:Aged; D000437:Alcoholism / Q000453:epidemiology; D001569:Benzodiazepines / Q000506:poisoning*; D002220:Carbamazepine / Q000506:poisoning; D003128:Coma / Q000139:chemically induced / Q000453:epidemiology / Q000628:therapy; D000431:Ethanol / Q000506:poisoning; D005260:Female; D005442:Flumazenil / Q000627:therapeutic use; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000453:epidemiology; D008875:Middle Aged; D011044:Poland / Q000453:epidemiology; D019966:Substance-Related Disorders / Q000453:epidemiology; D013406:Suicide, Attempted / Q000523:psychology / Q000706:statistics & numerical data*
D001569:Benzodiazepines; D002220:Carbamazepine; D000431:Ethanol; D005442:Flumazenil