title: Screening for prostatic carcinoma with prostate specific antigen.
abstract: The usefulness of prostate specific antigen (PSA) in screening for prostatic carcinoma was studied in 262 inpatients of the department of internal medicine. All patients underwent a rectal digital examination and determination of PSA by the Tandem-E method (Hybritech). The plan was to perform biopsies if there were suspicious findings on the rectal examination or if the PSA value was more than 10 ng/ml. The PSA values were < or = 4 ng/ml in 219 patients (83.6%), > 4 to 10 ng/ml in 27 patients (10.3%) and > 10 ng/ml in 16 men (6.1%). In consideration of the severity of disease which limited life expectancy we did not perform a biopsy on 37.5% of the patients with PSA > 10 ng/ml. 7 patients with prostatic carcinoma were found. Their PSA values varied between 11.2 and 875 ng/ml. The cancer detection rate was highest for the combination of a suspicious rectal examination and a PSA value > 10 ng/ml (70%).
authors.affiliation: Department of Urology, Ludwig Maximilians University, Munich, Germany.
authors.forename: R
authors.initials: R
authors.lastname: Waidelich
authors.forename: H M
authors.initials: HM
authors.lastname: Jansen
authors.forename: P
authors.initials: P
authors.lastname: Stieber
authors.forename: N
authors.initials: N
authors.lastname: Schmeller
authors.forename: R
authors.initials: R
authors.lastname: Lamerz
authors.forename: K
authors.initials: K
authors.lastname: Werdan
authors.forename: A
authors.initials: A
authors.lastname: Fateh-Moghadam
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D006801:Humans; D008297:Male; D008875:Middle Aged; D017430:Prostate-Specific Antigen / Q000097:blood*; D011471:Prostatic Neoplasms / Q000175:diagnosis*
chemical_list: D017430:Prostate-Specific Antigen