title: Sequencing analysis of prion genes from red deer and camel.
abstract: An abnormal isoform of the prion protein (PrP) appears to be the agent responsible for transmissible spongiform encephalopathies (TSE). The normal isoform of PrP is host-encoded and expressed in the central nervous system. The recent bovine spongiform encephalopathy (BSE) epidemic in the UK and the incidence of prion-related diseases in other animals could indicate that ruminants are highly susceptible to infection via ingestion of prion-contaminated food. Sequence analysis of PrP gene open reading frames from red deer and camel was carried out to investigate sequence variability of these genes among ruminants.
authors.affiliation: University of Nottingham, Sutton Bonington Campus, Loughborough, UK. virukalu@savba.sk
authors.forename: S
authors.initials: S
authors.lastname: Kaluz
authors.forename: M
authors.initials: M
authors.lastname: Kaluzova
authors.forename: A P
authors.initials: AP
authors.lastname: Flint
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002162:Camelus / Q000235:genetics*; D003670:Deer / Q000235:genetics*; D014644:Genetic Variation; D008969:Molecular Sequence Data; D016366:Open Reading Frames / Q000235:genetics; D011328:Prions / Q000737:chemistry / Q000235:genetics*; D017422:Sequence Analysis, DNA; D017386:Sequence Homology, Amino Acid; D012689:Sequence Homology, Nucleic Acid
chemical_list: D011328:Prions