title: Fine-needle aspiration of 697 palpable breast lesions with histopathologic correlation.
abstract: BACKGROUND
  Fine-needle aspiration breast biopsy has been used increasingly as an alternative to excisional biopsy. The purpose of this study is to evaluate the accuracy of fine-needle aspiration with histopathologic confirmation.
  
  
  METHODS
  A retrospective study was performed using a computer database over a 5-year period. All women who had had fine-needle aspiration breast biopsy with histopathologic confirmation of the diagnosis were included. Fine-needle aspirations were interpreted as malignant, suspicious, or benign. Histopathologic diagnosis included core-needle biopsy, open excisional biopsy, or mastectomy specimen.
  
  
  RESULTS
  A total of 697 patients fulfilled the criteria. Only 5 (0.7%) of the specimens were inadequate for study. There were 401 total malignant fine-needle aspiration diagnoses, with only 3 false-positive specimens. All three were ductal hyperplasia, one from a previously radiated breast. There were 125 suspicious readings; 84 of these were malignant and 41 were false-suspicious specimens. Most of the false-suspicious lesions were fibrocystic disease. Of the 166 lesions interpreted as benign, there were 13 false-negative specimens. The test had a 97% sensitivity, 78% specificity, 92% positive predictive value, and 92% negative predictive value.
  
  
  CONCLUSIONS
  Fine-needle aspiration is a sensitive test that can be useful as an adjunct in the diagnosis of breast cancer. "Malignant" and "benign" interpretations are highly predictive but must be used only in the context of other diagnostic modalities. "Suspicious" lesions require further investigation.
authors.affiliation: Department of Surgery, Loyola University Medical Center, Maywood, Ill. 60153, USA.
authors.forename: S
authors.initials: S
authors.lastname: O'Neil
authors.forename: M
authors.initials: M
authors.lastname: Castelli
authors.forename: P
authors.initials: P
authors.lastname: Gattuso
authors.forename: L
authors.initials: L
authors.lastname: Kluskens
authors.forename: K
authors.initials: K
authors.lastname: Madsen
authors.forename: G
authors.initials: G
authors.lastname: Aranha
mesh_terms: D001707:Biopsy, Needle; D001940:Breast / Q000166:cytology / Q000473:pathology*; D001941:Breast Diseases / Q000473:pathology*; D001943:Breast Neoplasms / Q000473:pathology* / Q000601:surgery; D019992:Databases as Topic; D005188:False Negative Reactions; D005189:False Positive Reactions; D005260:Female; D005348:Fibrocystic Breast Disease / Q000473:pathology*; D006801:Humans; D008408:Mastectomy; D016347:Medical Records Systems, Computerized; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012680:Sensitivity and Specificity