[Aminopeptidases in cells of non-Hodgkin's lymphoma of varying degrees of malignancy and in lymphogranulomatosis].
26 cases of lymphoproliferative diseases were studied: 8 cases of reactive follicular hyperplasia (RFH), 11 cases of non-Hodgkin's malignant lymphomas (NML), 7 cases of lymphogranulomatosis (LGM). Only gamma-glutamyl transpeptidase (GGT) was found in lymphoid cells of B- and T-dependent areas of lymph nodes with reactive changes as well as in tumor cells of NML and LGM. GGT activity was more pronounced in NML of high-grade malignancy (centroblast and immunoblast) as compared to lymphomas of lower grade of malignancy (lymphocytic, centroblast-centrocytic and in Lennert lymphoma). GGT activity in cells of Hodgkin and Berezovsky-Sterberg in some cases of LGM was high, in others low. Significant differences in GGT activity between RFH and follicular centroblast-centrocytic lymphoma were not found. Activity of aminopeptidase M was observed in histiocytes, fibroblasts, vessels and areas of connective tissue growth. Aminopeptidase A activity was observed in vessels only. Activity of dipeptidyl(amino)peptidase IV was observed in some lymphoid cells in RFH, NML and LGM. Thus, GGT activity may be considered as a differential-diagnostic marker in separating NML of high and low degree of malignancy and this may presume a different sensitivity to the therapy.
Bukaeva
I A
IA
Institute of Anatomy, Free University, Berlin, Germany.
Raĭkhlin
N T
NT
Probatova
N A
NA
Smirnova
E A
EA
Tupitsyn
N N
NN
Sholokhova
E N
EN
Gossrau
R
R
D000626:Aminopeptidases / Q000032:analysis*; D001402:B-Lymphocytes / Q000201:enzymology / Q000473:pathology; D006689:Hodgkin Disease / Q000201:enzymology* / Q000473:pathology; D006801:Humans; D006965:Hyperplasia / Q000201:enzymology / Q000473:pathology; D008228:Lymphoma, Non-Hodgkin / Q000201:enzymology* / Q000473:pathology; D013601:T-Lymphocytes / Q000201:enzymology / Q000473:pathology
D000626:Aminopeptidases