Chronic granulomatous disease masquerading as a bladder tumor: a potential source of diagnostic error.
Chronic granulomatous disease (CGD) is a rare inherited disease of childhood, characterized by recurrent bacterial or fungal infections. The underlying defect is a dysfunction of neutrophil granulocytes interfering with their ability to kill phagocytosed microorganisms. Genitourinary tract involvement has been reported in 38% of these patients. We report a case of CGD in whom the most important findings were urinary bladder tumors at different locations and a subsequent obstruction of the left ureter. A review of the pathogenesis of the disease, potential involvement of the urinary tract and treatment is presented.
Bendhack
M L
ML
Department of Urology, School of Medicine, Heinrich Heine University, Düsseldorf, Germany.
Vögeli
T
T
Schroten
H
H
Gerharz
C D
CD
Ackermann
R
R
D000328:Adult; D003558:Cystoscopy; D003937:Diagnosis, Differential; D006105:Granulomatous Disease, Chronic / Q000150:complications / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D006869:Hydronephrosis / Q000209:etiology; D008279:Magnetic Resonance Imaging; D008297:Male; D009092:Mucous Membrane / Q000473:pathology; D011127:Polyps / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D014463:Ultrasonography; D014513:Ureter / Q000473:pathology; D001749:Urinary Bladder Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology