title: Methohexital-induced changes in spectral power of neuromagnetic signals: beta augmentation is smaller over the hemisphere containing the epileptogenic focus.
abstract: Previous research has suggested that methohexital, a short-term barbiturate, alters activity in the primary epileptogenic area. It can be assumed that drug-induced activation of the epileptogenic focus provides a rapid and safe method to obtain a sufficient amount of information relevant for the lateralization and localisation of the primary epileptogenic area. This study shows that methohexital changes spectral power in the beta band derived from magnetoencephalographic (MEG) signals over the hemisphere ipsilateral to the primary epileptogenic area. This effect was demonstrated for 10/13 of the investigated patients suffering from unilateral temporal lobe epilepsy (TLE). The side and location of the primary epileptogenic area of these patients (5 left TLE, 8 right TEL) was determined invasively during presurgical evaluation. During a 1-2 minute interval after intravenous bolus injection of 100 mg methohexital a clear lateralization effect in the beta band was observed, which differed marginally between fronto-central, fronto-temporal and temporo-parietal brain regions. In addition, bilateral spectral power changes were obtained in the theta, alpha and gamma bands that differed between brain regions. Analyses of simultaneously recorded scalp electroencephalographic (EEG) data revealed effects consistent with those of the MEG analysis. The reduced enhancement of beta band spectral power of MEG recordings provides a potential application for the non-invasive lateralization of the primary epileptogenic area.
authors.affiliation: Institute for Experimental Audiology, University of Münster, Germany. chris@schweden.uni-muenster.de
authors.forename: C
authors.initials: C
authors.lastname: Wienbruch
authors.forename: C
authors.initials: C
authors.lastname: Eulitz
authors.forename: K
authors.initials: K
authors.lastname: Lehnertz
authors.forename: A
authors.initials: A
authors.lastname: Brockhaus
authors.forename: C E
authors.initials: CE
authors.lastname: Elger
authors.forename: T
authors.initials: T
authors.lastname: Elbert
authors.forename: M
authors.initials: M
authors.lastname: Hoke
mesh_terms: D000328:Adult; D001921:Brain / Q000187:drug effects / Q000503:physiopathology*; D001931:Brain Mapping; D004569:Electroencephalography / Q000187:drug effects / Q000379:methods; D004833:Epilepsy, Temporal Lobe / Q000503:physiopathology*; D005189:False Positive Reactions; D007839:Functional Laterality; D006801:Humans; D015225:Magnetoencephalography / Q000187:drug effects* / Q000295:instrumentation / Q000379:methods; D008723:Methohexital / Q000494:pharmacology*; D015203:Reproducibility of Results; D013997:Time Factors
chemical_list: D008723:Methohexital