Effect of selected triterpenoids on chronic dermal inflammation.
The activity of four natural triterpenoids on a 12-O-tetradecanoylphorbol-13-acetate multiple-dose model of skin chronic inflammation was studied. Erythrodiol and ursolic acid were significantly effective. The most important features concerning structure-activity relationship and previous data on the effect of these triterpenoids on other inflammatory conditions are discussed.
Máñez
S
S
Departament de Farmacologia, Universitat de València, Spain.
Recio
M C
MC
Giner
R M
RM
Ríos
J L
JL
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D003877:Dermatitis, Contact / Q000188:drug therapy*; D003907:Dexamethasone / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical; D005260:Female; D051379:Mice; D009828:Oleanolic Acid / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology; D053978:Pentacyclic Triterpenes; D013755:Tetradecanoylphorbol Acetate; D014315:Triterpenes / Q000737:chemistry / Q000494:pharmacology*; D000094062:Betulinic Acid; D000097245:Ursolic Acid
D000893:Anti-Inflammatory Agents; D003907:Dexamethasone; D009828:Oleanolic Acid; D053978:Pentacyclic Triterpenes; D013755:Tetradecanoylphorbol Acetate; D014315:Triterpenes; D000094062:Betulinic Acid; D000097245:Ursolic Acid; C077953:erythrodiol; C002503:betulin