Effect of increased intracranial pressure on arterial peripheral and cerebral blood pressure.
The effect of increased intracranial pressure (ICP) on arterial peripheral (PBP) and cerebral blood pressure (CBP) was studied in 16 rabbits (New Zealand White). Changes of arterial blood pressure in peripheral and cerebral blood circulation were caused by a temporary (3 min) ICP increase. A raised ICP was obtained by infusing into the left lateral brain ventricle artificial cerebrospinal fluid at a pressure equal to 50, 100, and 150% of the initial CBP value. The experiments carried out showed that on reaching the initial CBP value, increased ICP induced Cushing response. The magnitude and duration of this reaction changed with increasing ICP, the intensity of the changes depending on the brain region in which the ICP increase was initiated.
Dmowska
M
M
Department of Animal Physiology, M. Curie-Skłodowska University, Lublin, Poland.
Schoenborn
R
R
Modrzejewski
E
E
D000818:Animals; D001794:Blood Pressure; D002552:Cerebral Ventricles / Q000502:physiology; D002555:Cerebrospinal Fluid / Q000502:physiology; D007427:Intracranial Pressure; D008297:Male; D011817:Rabbits