[Change in bronchial hyperreactivity with nCPAP respiration in patients with sleep related respiratory disorders].
Own results of 23,174 patients suffering from sleep apnoea syndrome showed that about 4 per cent of these patients have an increase of bronchial reactivity. In 60 patients with assured bronchial hyperreactivity we performed an inhalative bronchial provocation test using carbachol. Tests were performed before and after two days of treatment with nCPAP in the early morning. 23 of our 60 patients showed a decrease of PD20 FEV1 after nCPAP. The other patients did not show any significant differences. Our results demonstrate that in patients with increased bronchial reactivity, nCPAP therapy may aggravate bronchial hyperreactivity.
Thalhofer
S
S
Pneumologisches Zentrum, DRK-Krankenhaus Mark Brandenburg, FU Berlin.
Dorow
P
P
Meissner
P
P
Luding
K
K
D000328:Adult; D000368:Aged; D000403:Airway Resistance / Q000502:physiology; D001980:Bronchi / Q000503:physiopathology; D016535:Bronchial Hyperreactivity / Q000503:physiopathology* / Q000628:therapy; D001985:Bronchial Provocation Tests; D002217:Carbachol; D000075202:Contraindications; D005260:Female; D005541:Forced Expiratory Volume / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011175:Positive-Pressure Respiration; D012891:Sleep Apnea Syndromes / Q000503:physiopathology* / Q000628:therapy
D002217:Carbachol