Orthopaedic surgery in hemophilic patients with human immunodeficiency virus.
Patients registered at the author's hemophilia center between 1982 and 1994 were studied to establish whether major orthopaedic surgical procedures accelerate the fall of CD4 lymphocyte counts of patients with hemophilia who are infected with the human immunodeficiency virus, and whether patients who had surgery had different rates of development of acquired immune deficiency syndrome or death when compared with patients who did not have surgery. The patients were divided into four groups: Group 1, 22 patients who were human immunodeficiency virus positive undergoing orthopaedic surgery; Group 2, 89 patients who were human immunodeficiency virus positive not undergoing orthopaedic surgery; Group 3, 18 patients who were human immunodeficiency virus negative undergoing orthopaedic surgery; and Group 4, 135 patients who were human immunodeficiency virus negative not undergoing orthopaedic surgery. There was no significant difference between the rates of decline of CD4 lymphocyte counts for patients who were human immunodeficiency virus positive who underwent surgery when compared with human immunodeficiency virus positive patients who did not undergo surgery, nor was there any significant difference between the two human immunodeficiency virus negative groups. There were no significant differences in the rate of development of acquired immune deficiency syndrome or mortality rates between patients who had surgery and those who did not.
Phillips
A M
AM
Royal Free Hospital, Northampton, United Kingdom.
Sabin
C A
CA
Ribbans
W J
WJ
Lee
C A
CA
D000163:Acquired Immunodeficiency Syndrome / Q000097:blood / Q000150:complications; D000843:Ankle Joint / Q000601:surgery; D018791:CD4 Lymphocyte Count; D002423:Cause of Death; D018450:Disease Progression; D004551:Elbow Joint / Q000601:surgery; D017558:Elective Surgical Procedures; D005500:Follow-Up Studies; D015658:HIV Infections / Q000097:blood / Q000150:complications; D018023:HIV Seronegativity; D006679:HIV Seropositivity / Q000097:blood / Q000150:complications*; D006467:Hemophilia A / Q000097:blood / Q000150:complications / Q000601:surgery*; D002836:Hemophilia B / Q000097:blood / Q000150:complications / Q000601:surgery; D006801:Humans; D007592:Joint Diseases / Q000209:etiology / Q000601:surgery; D007596:Joints / Q000601:surgery*; D007719:Knee Joint / Q000601:surgery; D011379:Prognosis; D014842:von Willebrand Diseases / Q000097:blood / Q000150:complications / Q000601:surgery