title: The stability and conformation of duplex DNA containing the novel anti-HIV drug ADRT.
abstract: The anti-HIV drug 4'-azidothymidine (ADRT) has been incorporated into DNA by the phosphoramidite method. The presence of the modified nucleotide was shown to have a minimal effect on duplex conformation and stability by CD spectroscopy and UV melting.
authors.affiliation: Zenaca Diagnostics, Northwich, England, U.K.
authors.forename: N J
authors.initials: NJ
authors.lastname: Gibson
authors.forename: C M
authors.initials: CM
authors.lastname: McKellar
authors.forename: T
authors.initials: T
authors.lastname: Brown
mesh_terms: D019380:Anti-HIV Agents / Q000737:chemistry*; D002942:Circular Dichroism; D004247:DNA / Q000737:chemistry*; D009690:Nucleic Acid Conformation; D013816:Thermodynamics; D015215:Zidovudine / Q000031:analogs & derivatives* / Q000737:chemistry
chemical_list: D019380:Anti-HIV Agents; C072200:4'-azidothymidine; D015215:Zidovudine; D004247:DNA