title: Successful surgery of multiple recurrent basal cell carcinomas guided by photodynamic diagnosis.
abstract: We describe a 56-year-old Caucasian man with history of multiple regressed basal cell carcinomas. During the last 20 years approximately 200 histologically proven basal cell carcinomas preferentially localized on the face were surgically treated. Several large skin grafts were necessary to cover the extensive tissue defects on the face and scalp. Although all excised tissues were histologically proven to be basal cell carcinomas with tumor-free margins, new tumors developed in proximity to the skin graft margins. The dissemination of the new tumors made it difficult to perform additional invasive operation procedures without influencing the cosmetic result. Thus, we used photodynamic diagnosis to improve detection and demarcation of the neoplastic tissues. This procedure facilitated surgical planning and enabled primary in toto excisions. Surgical trauma and a number of interventions were thus minimized with the consequence of improved cosmetic and functional results.
authors.affiliation: Düsseldorf, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Fritsch
authors.forename: P M
authors.initials: PM
authors.lastname: Becker-Wegerich
authors.forename: H
authors.initials: H
authors.lastname: Menke
authors.forename: T
authors.initials: T
authors.lastname: Ruzicka
authors.forename: G
authors.initials: G
authors.lastname: Goerz
authors.forename: R R
authors.initials: RR
authors.lastname: Olbrisch
mesh_terms: D000622:Aminolevulinic Acid / Q000627:therapeutic use; D002280:Basal Cell Carcinoma / Q000473:pathology / Q000601:surgery / Q000628:therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D010778:Photochemotherapy / Q000379:methods*; D012878:Skin Neoplasms / Q000473:pathology / Q000601:surgery / Q000628:therapy
chemical_list: D000622:Aminolevulinic Acid