title: Occupational asthma in an isothiazolinone manufacturing plant.
abstract: A chemical plant operator developed asthma five months after starting work in an isothiazolinone manufacturing plant. He described symptoms of late asthmatic reactions after work with isothiazolinone. Airway responsiveness to methacholine improved tenfold when he was removed from the plant for 18 days. A workplace challenge study then resulted in a deterioration in airway responsiveness to its earlier level and in progressive falls in forced expiratory volume in one second (FEV1) over three days at work compared with control days, indicating statistically significant late asthmatic reactions of increasing severity.
authors.affiliation: Department of Respiratory Medicine, Newcastle General Hospital, University of Newcastle upon Tyne, UK.
authors.forename: S J
authors.initials: SJ
authors.lastname: Bourke
authors.forename: R P
authors.initials: RP
authors.lastname: Convery
authors.forename: S C
authors.initials: SC
authors.lastname: Stenton
authors.forename: R M
authors.initials: RM
authors.lastname: Malcolm
authors.forename: D J
authors.initials: DJ
authors.lastname: Hendrick
mesh_terms: D000890:Anti-Infective Agents / Q000009:adverse effects*; D001249:Asthma / Q000139:chemically induced* / Q000175:diagnosis; D001985:Bronchial Provocation Tests; D016085:Bronchoconstrictor Agents; D002617:Chemical Industry; D005541:Forced Expiratory Volume; D006801:Humans; D008297:Male; D016210:Methacholine Chloride; D008875:Middle Aged; D009784:Occupational Diseases / Q000139:chemically induced* / Q000175:diagnosis
chemical_list: D000890:Anti-Infective Agents; D016085:Bronchoconstrictor Agents; D016210:Methacholine Chloride