Beta-lactamases of Mycobacterium tuberculosis and Mycobacterium kansasii.
Re-emergence of infectious diseases caused by mycobacteria as well as the emergence of multiresistant strains of Mycobacterium has promoted the research on the use of beta-lactames in the treatment of such diseases. Mycobacteria produce beta-lactamases: M. tuberculosis produces a wide-spectrum beta-lactamase whose behaviour mimicks those of Gram-negative bacteria. M. kansasii produces also beta-lactamase which can be inhibited by clavulanic acid. An overview on beta-lactamases from both species is reported.
Segura
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Departament de Genètica i Microbiologia, Universitat Autònoma de Barcelona, Spain.
Salvadó
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D000995:Antitubercular Agents / Q000378:metabolism / Q000494:pharmacology; D002463:Cell Membrane Permeability; D002473:Cell Wall / Q000502:physiology; D019818:Clavulanic Acid / Q000494:pharmacology; D004352:Drug Resistance, Microbial / Q000235:genetics; D018432:Drug Resistance, Multiple / Q000235:genetics; D004791:Enzyme Inhibitors / Q000494:pharmacology; D019909:Mycobacterium kansasii / Q000187:drug effects / Q000201:enzymology* / Q000235:genetics; D009169:Mycobacterium tuberculosis / Q000187:drug effects / Q000201:enzymology* / Q000235:genetics; D013045:Species Specificity; D065093:beta-Lactamase Inhibitors; D001618:beta-Lactamases / Q000235:genetics / Q000302:isolation & purification / Q000502:physiology*
D000995:Antitubercular Agents; D004791:Enzyme Inhibitors; D065093:beta-Lactamase Inhibitors; D019818:Clavulanic Acid; D001618:beta-Lactamases