title: Reorganization of verbal memory function in early onset left temporal lobe epilepsy.
abstract: The purpose of this investigation was to examine the issue of reorganization of verbal memory function following early insult to the left mesial temporal region. It was hypothesized that reorganization of memory function was most likely to occur in those patients with an early age of seizure onset who have a more limited degree of extra-hippocampal neuropathology. Fifty-four patients with epilepsy of unequivocal left temporal lobe origin were classified into four groups on the basis of the presence/absence of hippocampal sclerosis and degree of postoperative seizure relief. Measures of verbal learning and memory as well as nonmemory measures were administered both before and 6 to 8 months after anterior temporal lobectomy. Findings were consistent with the reorganization proposal. The clinical and theoretical significance of the findings are discussed.
authors.affiliation: Department of Psychology, Chicago Medical School, Illinois 60064, USA.
authors.forename: M
authors.initials: M
authors.lastname: Seidenberg
authors.forename: B P
authors.initials: BP
authors.lastname: Hermann
authors.forename: J
authors.initials: J
authors.lastname: Schoenfeld
authors.forename: K
authors.initials: K
authors.lastname: Davies
authors.forename: A
authors.initials: A
authors.lastname: Wyler
authors.forename: F C
authors.initials: FC
authors.lastname: Dohan
mesh_terms: D000328:Adult; D004833:Epilepsy, Temporal Lobe / Q000150:complications* / Q000473:pathology / Q000601:surgery; D005260:Female; D007839:Functional Laterality; D006624:Hippocampus / Q000473:pathology / Q000601:surgery; D006801:Humans; D008297:Male; D008569:Memory Disorders / Q000175:diagnosis / Q000209:etiology*; D009483:Neuropsychological Tests; D012598:Sclerosis / Q000473:pathology / Q000601:surgery; D012720:Severity of Illness Index