[Level of vasopressin in renal venous blood of patients with renovascular hypertension due to unilateral stenosis of renal arteries].
Assessment of plasma renin activity (PRA) in renal vein blood is used in the diagnosis of unilateral renovascular hypertension (URVH). Recently also other markers of renal ischaemia (atrial natriuretic peptide, adrenalin, nonadrenaline and dopamine) have been described. The present study aimed to assess renal handling of vasopressin (AVP) by the ischaemic kidney in patients with URVH. In 16 patients with URVH, PRA and AVP were estimated in renal vein blood of the ischemic (IK) and non-ischemic kidney (NK), in arterial blood (A) and in blood samples withdrawn from the inferior vena cava (VCI) below the orifices of the renal veins. In contrast to PRA no significant difference between plasma levels of AVP in renal vein blood of the ischaemic and non-ischaemic kidney was noticed (4.8 +/- 0.9 pg/ml vs 5.1 +/- 0.8 pg/ml respectively).


CONCLUSIONS
Chronic hypoperfusion of the kidney does not influence renal handling of AVP in patients with URVH. Thus assessment of AVP in renal vein blood in these patients is deprived of diagnostic value.
Kiersztejn
M
M
Katedry i Kliniki Nefrologii Slaskiej Akademii Medycznej w Katowicach.32
Wiecek
A
A
Kokot
F
F
Kuczera
M
M
D000328:Adult; D015415:Biomarkers / Q000097:blood; D005260:Female; D006801:Humans; D006977:Hypertension, Renal / Q000097:blood* / Q000175:diagnosis / Q000209:etiology; D007511:Ischemia / Q000097:blood / Q000150:complications / Q000175:diagnosis; D007668:Kidney / Q000098:blood supply; D008297:Male; D008875:Middle Aged; D012078:Renal Artery Obstruction / Q000097:blood* / Q000150:complications; D014667:Vasopressins / Q000097:blood*
D015415:Biomarkers; D014667:Vasopressins