Therapeutic drug monitoring opportunities in cancer therapy.
Cancer is a common cause of death, and improvements in treatment are desperately needed. The high degree of variation in systemic exposure for a given dose and the relationships between blood concentrations and either toxic or antitumor effects would suggest that therapeutic drug monitoring is a potential mechanism for improving the treatment of individual patients. In this review, the case for therapeutic drug monitoring is made in a select number of commonly used cancer drugs and areas that require more concerted effort are highlighted.
McLeod
H L
HL
Department of Medicine and Therapeutics, University of Aberdeen, UK.
D000970:Antineoplastic Agents / Q000592:standards / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D016903:Drug Monitoring / Q000592:standards* / Q000639:trends*; D005544:Forecasting; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy*
D000970:Antineoplastic Agents