title: Infections in IFNGR-1-deficient children.
abstract: Human interferon-gamma receptor 1 (IFNGR-1) deficiency is a newly identified autosomal recessive inherited immune disorder. Children with IFNGR-1 deficiency exhibit a severe, profound and selective susceptibility to weakly virulent mycobacteria, such as bacillus Calmette-Guerin (BCG) vaccine or environmental nontuberculous mycobacteria (NTM). This review compares the infections found in IFNGR-1-deficient children to those in IFN-gamma-deficient or IFNGR-1-deficient mice.
authors.affiliation: INSERM U429, Hôpital Necker-Enfants Malades, Paris, France.
authors.forename: E
authors.initials: E
authors.lastname: Jouanguy
authors.forename: F
authors.initials: F
authors.lastname: Altare
authors.forename: S
authors.initials: S
authors.lastname: Lamhamedi-Cherradi
authors.forename: J L
authors.initials: JL
authors.lastname: Casanova
mesh_terms: D000818:Animals; D001424:Bacterial Infections / Q000503:physiopathology; D002648:Child; D006801:Humans; D007239:Infections / Q000503:physiopathology*; D007371:Interferon-gamma; D051379:Mice; D010272:Parasitic Diseases / Q000503:physiopathology; D017471:Receptors, Interferon / Q000172:deficiency*; D014777:Virus Diseases / Q000503:physiopathology; D000096743:Interferon gamma Receptor
chemical_list: D007371:Interferon-gamma; D017471:Receptors, Interferon; D000096743:Interferon gamma Receptor