title: Dynamics of MLAEP changes in midazolam-induced sedation.
abstract: This study aimed at assessing the effects of midazolam (MDZ) sedation on auditory brainstem (BAEP) and middle latency (MLAEP) evoked potentials in intensive care conditions. Ten ventilated comatose patients were receiving an intravenous MDZ bolus dose (0.2 mg/kg) followed by a 2 h continuous infusion (0.1 mg/kg/h). MLAEPs and BAEPs elicited by clicks (90 dB HL + masking) were simultaneously and continuously monitored during the first 6 h and for 30 min the next morning. We found no effect of MDZ sedation on BAEPs. Only MLAEP components were modified. However, none of the patients presented any total abolition of the MLAEPs. Bolus injection led to very early alteration of cortical responses, beginning after 5 min and lasting almost 1 h (maximum Pa latency increase, 3.1 ms; maximum Pa-Nb amplitude decrease, 46%). During continuous infusion, MLAEPs remained slightly, although significantly, altered (Pa latency, +1.3 ms; Pa-Nb amplitude, 27%). The Nb wave seemed to be modified earlier and to return to normality later than the Pa wave. These findings incite a careful interpretation of MLAEP tracings acquired during the first hour following MDZ bolus injection. If possible, MDZ should be administered as continuous infusion for reliable interpretation of evoked potential changes in intensive care unit, or during surgery.
authors.affiliation: Mental Process and Brain Activation, INSERM U280, Lyon, France. morlet@lyon151.inserm.fr
authors.forename: D
authors.initials: D
authors.lastname: Morlet
authors.forename: O
authors.initials: O
authors.lastname: Bertrand
authors.forename: F
authors.initials: F
authors.lastname: Salord
authors.forename: R
authors.initials: R
authors.lastname: Boulieu
authors.forename: J
authors.initials: J
authors.lastname: Pernier
authors.forename: C
authors.initials: C
authors.lastname: Fischer
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003128:Coma / Q000188:drug therapy* / Q000503:physiopathology; D004569:Electroencephalography; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D006801:Humans; D006993:Hypnotics and Sedatives / Q000494:pharmacology*; D008297:Male; D008874:Midazolam / Q000494:pharmacology*; D008875:Middle Aged
chemical_list: D006993:Hypnotics and Sedatives; D008874:Midazolam