Effects of repeated administration of dithiol chelating agent--sodium 2,3-dimercapto-1-propanesulphonate (DMPS)--on biochemical and haematological parameters in rabbits.
The effects of weekly intravenously administered a dithiol chelating agent-sodium 2,3-dimercaptopropane-sulphonate (DMPS)-in a single dose of 50 mg/kg/week for 10 weeks on biochemical and haematological parameters were studied in rabbits. DMPS was well tolerated, an increase in body weight was similar in the DMPS-treated and control animals. DMPS caused significant decrease in plasma calcium and vitamin E concentrations at the end of the experiment. No significant differences in haematological parameters between the DMPS and control groups were observed. A significant decrease in magnesium content in myocardial tissue was observed in the DMPS-treated rabbits. The above-mentioned biochemical changes should be taken into account in studies of possible chelating and radical scavenging effects of DMPS in various pathological conditions.
Gersl
V
V
Department of Pharmacology, Charles University, Faculty of Medicine, Hradec Králové.
Hrdina
R
R
Vávrová
J
J
Holecková
M
M
Palicka
V
V
Voglová
J
J
Mazurová
Y
Y
Bajgar
J
J
D000818:Animals; D001769:Blood / Q000187:drug effects*; D001772:Blood Cell Count / Q000187:drug effects; D001774:Blood Chemical Analysis; D001835:Body Weight / Q000187:drug effects; D002614:Chelating Agents / Q000008:administration & dosage / Q000494:pharmacology*; D007275:Injections, Intravenous; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D011817:Rabbits; D014494:Unithiol / Q000008:administration & dosage / Q000494:pharmacology*
D002614:Chelating Agents; D014494:Unithiol