Bicyclo[2.2.1]heptane and 6,6-dimethylbicyclo[3.1.1]heptane derivatives: orally active, potent, and selective prostaglandin D2 receptor antagonists.
Tsuri
T
T
Shionogi Research Laboratories, Shionogi & Co., Ltd., Osaka, Japan.
Honma
T
T
Hiramatsu
Y
Y
Okada
T
T
Hashizume
H
H
Mitsumori
S
S
Inagaki
M
M
Arimura
A
A
Yasui
K
K
Asanuma
F
F
Kishino
J
J
Ohtani
M
M
D000284:Administration, Oral; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D001792:Blood Platelets / Q000187:drug effects; D001643:Bridged Bicyclo Compounds / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D006168:Guinea Pigs; D006801:Humans; D009636:Norbornanes / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D015230:Prostaglandin D2 / Q000378:metabolism*; D011971:Receptors, Immunologic; D011982:Receptors, Prostaglandin / Q000008:administration & dosage* / Q000378:metabolism; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D000894:Anti-Inflammatory Agents, Non-Steroidal; D001643:Bridged Bicyclo Compounds; D009636:Norbornanes; D011971:Receptors, Immunologic; D011982:Receptors, Prostaglandin; D015230:Prostaglandin D2; C036293:prostaglandin D2 receptor