title: Prominent sensory ataxia in Guillain-Barré syndrome associated with IgG anti-GD1b antibody.
abstract: Sensitization with GD1b has been shown to cause sensory neuropathy in rabbit. A patient with chronic sensory-dominant polyneuropathy who had IgM antibody specifically to GD1b has been reported previously. This report describes the first patient with acute demyelinating polyneuropathy with prominent sensory symptoms who had a high titer of serum IgG anti-GD1b antibody. The serum reacted with neither GM1 nor with other b-series gangliosides (GD2, GD3, GT1b and GQ1b). Improvement in symptoms was coincident with decrease in IgG anti-GD1b antibody titer after plasmapheresis. This case supports the experimental results in rabbit suggesting that anti-GD1b antibody functions in the development of sensory ataxia.
authors.affiliation: Dept. of Neurology, University Hospital Eppendorf, Hamburg, Germany.
authors.forename: E M
authors.initials: EM
authors.lastname: Wicklein
authors.forename: G
authors.initials: G
authors.lastname: Pfeiffer
authors.forename: N
authors.initials: N
authors.lastname: Yuki
authors.forename: C
authors.initials: C
authors.lastname: Hartard
authors.forename: K
authors.initials: K
authors.lastname: Kunze
mesh_terms: D001259:Ataxia / Q000150:complications*; D003711:Demyelinating Diseases / Q000473:pathology / Q000503:physiopathology; D004797:Enzyme-Linked Immunosorbent Assay; D005732:Gangliosides / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D011129:Polyradiculoneuropathy / Q000150:complications* / Q000276:immunology*
chemical_list: D005732:Gangliosides; D007074:Immunoglobulin G; C033851:ganglioside, GD1b