A multivariable risk factor analysis of the portoenterostomy (Kasai) procedure for biliary atresia: twenty-five years of experience from two centers.
OBJECTIVE
The authors investigated risk factors for failure after portoenterostomy for biliary atresia using univariate and multivariable methods.


BACKGROUND
Kasai's portoenterostomy has gained worldwide acceptance as the initial surgical therapy for infants with biliary atresia. Although extended survival has been achieved for many patients, factors influencing outcome have not been defined clearly.


METHODS
The authors analyzed risks for failure in 266 patients treated from 1972 to 1996 by the Kaplan-Meier product limit estimate and Cox proportional hazards model. Failure was defined as death or transplant.


RESULTS
Age at surgery, surgical decade, and anatomy of atretic bile ducts were identified as independent risk factors. Five-year survival was 49% and median survival was 15 years when bile drainage was achieved. Sixty-five patients had liver transplants. Mean age at transplant was 5.4 years.


CONCLUSIONS
The outcome after portoenterostomy for biliary atresia is determined by age at surgery and anatomy of the atretic extrahepatic bile ducts. Liver transplant will salvage patients with failed Kasai with 10-year posttransplant survival of 71%.
Altman
R P
RP
Department of Surgery, College of Physicians & Surgeons, Columbia University, Babies & Children's Hospital of New York, NY 10032, USA.
Lilly
J R
JR
Greenfeld
J
J
Weinberg
A
A
van Leeuwen
K
K
Flanigan
L
L
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000713:Anastomosis, Roux-en-Y; D001652:Bile Ducts / Q000473:pathology / Q000503:physiopathology; D001656:Biliary Atresia / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D001706:Biopsy; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D008099:Liver / Q000473:pathology; D016031:Liver Transplantation; D015999:Multivariate Analysis; D011171:Portoenterostomy, Hepatic / Q000009:adverse effects*; D016016:Proportional Hazards Models; D012307:Risk Factors; D016019:Survival Analysis; D015996:Survival Rate; D016896:Treatment Outcome