Notulae seminologicae. 8. Ultrastructural sperm defects in two men, carriers of autosomal inversion.
The electron microscopical analysis of spermatozoa in two infertile male carriers of a pericentric inversion in one of the chromosomes 9 revealed the presence of a peculiar defect affecting the tails' fibrous sheath in both patients. This structure appeared completely disorganized and hyperplasic; sometimes the defect was associated with other usual malformations concerning the nuclear and acrosomal shape and texture and the axonemal assembly. Most spermatozoa (90-100%) of these patients were immotile. Our findings point to a definite ultrastructural sperm defect found in cases of autosomal inversion.
Baccetti
B
B
Istituto di Biologia Generale, Università di Siena, Italy.
Collodel
G
G
Crisà
D
D
Moretti
E
E
Piomboni
P
P
D000177:Acrosome / Q000648:ultrastructure; D000328:Adult; D002467:Cell Nucleus / Q000648:ultrastructure; D002843:Chromatin / Q000648:ultrastructure; D007446:Chromosome Inversion; D002899:Chromosomes, Human, Pair 9; D006801:Humans; D007248:Infertility, Male / Q000235:genetics* / Q000473:pathology*; D007621:Karyotyping; D008297:Male; D008854:Microscopy, Electron; D013094:Spermatozoa / Q000002:abnormalities* / Q000648:ultrastructure*
D002843:Chromatin