title: Optimal treatment of descending necrotising mediastinitis.
abstract: BACKGROUND
  Descending necrotising mediastinitis is caused by downward spread of neck infection and has a high fatality rate of 31%. The seriousness of this infection is caused by the absence of barriers in the contiguous fascial planes of neck and mediastinum.
  
  
  METHODS
  The recent successful treatment of seven adult patients with descending necrotising mediastinitis emphasises the importance of optimal early drainage of both neck and mediastinum and prolonged antibiotic therapy. The case is also presented of a child with descending necrotising mediastinitis, demonstrating the rapidity with which the infection can develop and lead to death. Twenty four case reports and 12 series of adult patients with descending necrotising mediastinitis published since 1970 were reviewed with meta-analysis. In each case of confirmed descending necrotising mediastinitis the method of surgical drainage (cervical, mediastinal, or none) and the survival outcome (discharge home or death) were noted. The chi 2 test of statistical significance was used to detect a difference between cases treated with cervical drainage alone and cases where mediastinal drainage was added.
  
  
  RESULTS
  Cervical drainage alone was often insufficient to control the infection with a fatality rate of 47% compared with 19% when mediastinal drainage was added (p < 0.05).
  
  
  CONCLUSIONS
  Early combined drainage with neck and chest incisions, together with broad spectrum intravenous antibiotics, should be considered standard care for this disease.
authors.affiliation: Department of Otolaryngology, University of Ottawa, Ontario, Canada.
authors.forename: M J
authors.initials: MJ
authors.lastname: Corsten
authors.forename: F M
authors.initials: FM
authors.lastname: Shamji
authors.forename: P F
authors.initials: PF
authors.lastname: Odell
authors.forename: J A
authors.initials: JA
authors.lastname: Frederico
authors.forename: G G
authors.initials: GG
authors.lastname: Laframboise
authors.forename: K R
authors.initials: KR
authors.lastname: Reid
authors.forename: E
authors.initials: E
authors.lastname: Vallieres
authors.forename: F
authors.initials: F
authors.lastname: Matzinger
mesh_terms: D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D004322:Drainage; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008297:Male; D008480:Mediastinitis / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000628:therapy*; D008875:Middle Aged; D009333:Neck; D009336:Necrosis; D013909:Thorax; D014057:Tomography, X-Ray Computed
chemical_list: D000900:Anti-Bacterial Agents