title: Effect of hyperthyroidism on antral myoelectrical activity, gastric emptying and dyspepsia in man.
abstract: OBJECTIVE
  The objective of the present study was to investigate the effect of hyperthyroidism on antral myoelectrical activity, gastric emptying and dyspepsia in man.
  
  
  METHODS
  Twenty-three patients with manifest hyperthyroidism and dyspepsia confirmed by a standardized protocol were studied by electrogastrography (EGG). The following EGG parameters were determined: dominant frequency (DF cycles per minute (cpm), DF (%) in the normal range (2-4 cpm)), bradygastria (< 2 cpm), tachygastria (4-10 cpm), dominant frequency instability coefficient (DFIC), and postprandial to fasting power ratio. Data were correlated to results obtained in 18 age- and gender-matched controls. In 10 patients, a control measurement was performed after antithyroid therapy. In addition, in 15 consecutive patients, EGG data were compared to gastric emptying of radionuclides recorded simultaneously (gamma camera).
  
  
  RESULTS
  Hyperthyroid patients revealed a significant increase in preprandial DF, and in pre- and post-prandial tachygastrias compared to controls (3.3 cpm vs 3.1 cpm; 8.8% vs 3.5%; 12.3% vs 3.5%; p < 0.05). After antithyroid therapy, postprandial tachygastrias were reduced significantly. About 50% of the patients exhibited delayed gastric emptying compared to previously evaluated normal values (t 60 nuclide retention: > 68%). However, these patients did not differ in tachygastria and the other EGG parameters from those with normal gastric emptying (p > 0.05). Both EGG and radioscintigraphy did not correlate significantly with dyspepsia.
  
  
  CONCLUSIONS
  Dyspeptic patients with hyperthyroidism frequently display tachygastria and delayed gastric emptying. However, tachygastria has no important effect on gastric motor activity in hyperthyroidism.
authors.affiliation: Department of Medicine and Radiology, St. Josef-Hospital, Ruhr-University, Bochum, Germany.
authors.forename: B
authors.initials: B
authors.lastname: Pfaffenbach
authors.forename: R J
authors.initials: RJ
authors.lastname: Adamek
authors.forename: D
authors.initials: D
authors.lastname: Hagelmann
authors.forename: J
authors.initials: J
authors.lastname: Schaffstein
authors.forename: M
authors.initials: M
authors.lastname: Wegener
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D004415:Dyspepsia / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D005260:Female; D005746:Gastric Emptying; D006801:Humans; D006980:Hyperthyroidism / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology*; D008297:Male; D016065:Myoelectric Complex, Migrating; D011877:Radionuclide Imaging; D013270:Stomach / Q000000981:diagnostic imaging