title: Benign cellular responses in rats to different wear particles in intra-articular and intramedullary environments.
abstract: We examined the cellular responses to various particles injected into the knees and the intramedullary femoral cavities of rats in the presence of polymethylmethacrylate (PMMA) plugs. The intra-articular particles were mainly ingested by synovial fibroblasts. Increased numbers of macrophages were not detected and there was only a slight increase in synovial thickness. Cellular responses in the intramedullary space were similarly mild and bone resorption around the PMMA plug did not occur. Bone formation was inhibited only by polyethylene particles. In contrast to current views, our study shows that wear particles per se do not initiate bone resorption.
authors.affiliation: Academic Medical Centre, Amsterdam, The Netherlands.
authors.forename: H M
authors.initials: HM
authors.lastname: Van Der Vis
authors.forename: R K
authors.initials: RK
authors.lastname: Marti
authors.forename: W
authors.initials: W
authors.lastname: Tigchelaar
authors.forename: H M
authors.initials: HM
authors.lastname: Schüller
authors.forename: C J
authors.initials: CJ
authors.lastname: Van Noorden
mesh_terms: D000818:Animals; D001862:Bone Resorption / Q000276:immunology; D002858:Chromium Alloys / Q000009:adverse effects*; D005269:Femur / Q000276:immunology*; D005347:Fibroblasts / Q000276:immunology; D007249:Inflammation / Q000276:immunology; D007719:Knee Joint / Q000276:immunology*; D008297:Male; D010316:Particle Size; D011095:Polyethylenes / Q000009:adverse effects*; D019904:Polymethyl Methacrylate / Q000494:pharmacology*; D011137:Polystyrenes / Q000009:adverse effects*; D011475:Prosthesis Failure; D051381:Rats; D017208:Rats, Wistar; D013583:Synovial Membrane / Q000276:immunology; D014025:Titanium / Q000009:adverse effects*; D015040:Zirconium / Q000009:adverse effects*
chemical_list: D002858:Chromium Alloys; D011095:Polyethylenes; D011137:Polystyrenes; D019904:Polymethyl Methacrylate; D015040:Zirconium; D014025:Titanium; C028541:zirconium oxide