Two new puriniums and three new pyrimidines from Heterostemma brownii.
Two new puriniums, heteromines D (4) and E (5), and three new pyrimidines, heteromines F (6), G (7), and H (8), were isolated from the aerial parts of Heterostemma brownii Hay. Their structures were determined as 7,9-dimethyl-2-(N,N-dimethylamino)guaninium chloride, 7,9-dimethyl-2-(N-methylamino)guaninium chloride, 6-methoxy-4-(N-methylamino)-2-(N,N-dimethylamino)-5- (N-methylformamido)pyrimidine, 6-methoxy-2,4-bis(N-methylamino)-5-(N-methylformamido)pyrimidine, and 2-amino-6-methoxy-4-(N-methylamino)-5-(N-methylformamido)-pyrimidi ne, respectively.
Lin
Y L
YL
National Research Institute of Chinese Medicine, Taipei, Taiwan, Republic of China.
Huang
R L
RL
Chang
C M
CM
Kuo
Y H
YH
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D011687:Purines / Q000302:isolation & purification* / Q000494:pharmacology; D011743:Pyrimidines / Q000302:isolation & purification* / Q000494:pharmacology; D051381:Rats; D014407:Tumor Cells, Cultured
D000972:Antineoplastic Agents, Phytogenic; D011687:Purines; D011743:Pyrimidines; C109380:heteromine D; C109382:heteromine E; C109381:heteromine F; C109383:heteromine G; C109384:heteromine H