title: Effect of ecabet sodium on Helicobacter pylori adhesion to gastric epithelial cells.
abstract: Helicobacter pylori is a major etiological agent in gastroduodenal disorders, with the adhesion of H. pylori to gastric epithelial cells being the initial step of H. pylori infection. Inhibition of H. pylori adhesion is thus a therapeutic target in preventing H. pylori infection. We evaluated the effect of ecabet sodium, an antiulcer agent, on H. pylori adhesion to gastric epithelial cells, using our previously established enzyme-linked immunosorbent assay. The adhesion of H. pylori was significantly inhibited by ecabet sodium in a dose-dependent manner. Our studies suggest that ecabet sodium inhibits the adhesion of H. pylori to gastric epithelial cells.
authors.affiliation: Department of Microbiology, School of Medicine, Sapporo Medical University, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Hayashi
authors.forename: T
authors.initials: T
authors.lastname: Sugiyama
authors.forename: A
authors.initials: A
authors.lastname: Yachi
authors.forename: K
authors.initials: K
authors.lastname: Yokota
authors.forename: Y
authors.initials: Y
authors.lastname: Hirai
authors.forename: K
authors.initials: K
authors.lastname: Oguma
authors.forename: N
authors.initials: N
authors.lastname: Fujii
mesh_terms: D045784:Abietanes; D000897:Anti-Ulcer Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001422:Bacterial Adhesion / Q000187:drug effects*; D002277:Carcinoma / Q000473:pathology; D004224:Diterpenes / Q000494:pharmacology* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004847:Epithelial Cells / Q000187:drug effects / Q000382:microbiology / Q000473:pathology; D005753:Gastric Mucosa / Q000187:drug effects / Q000382:microbiology* / Q000473:pathology; D016480:Helicobacter pylori / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D010437:Peptic Ulcer / Q000473:pathology; D013274:Stomach Neoplasms / Q000473:pathology; D014407:Tumor Cells, Cultured
chemical_list: D045784:Abietanes; D000897:Anti-Ulcer Agents; D004224:Diterpenes; C061681:ecabet