title: Surgical treatment of aortic arch aneurysms in profound hypothermia and circulatory arrest.
abstract: BACKGROUND
  This study was undertaken to define the factors that influence mortality rate and neurologic outcome after repair of the aortic arch and various portions of the thoracic aorta in patients with profound hypothermia and circulatory arrest.
  
  
  METHODS
  Between November 1986 and January 1996, 105 patients were treated surgically for aortic disease involving the transverse aortic arch. Profound hypothermic circulatory arrest and selective brachiocephalic perfusion was used in all patients. In 19 patients retrograde cerebral perfusion was instituted during the period of circulatory arrest. Independent predictors for 30-day mortality and permanent neurologic deficits were evaluated by multiple logistic regression.
  
  
  RESULTS
  Thirty-day mortality for the entire group was 19% (20/105); 21.2% for urgent versus 15.4% for elective cases, respectively. Statistical analysis showed that age is the most important factor that significantly influences mortality rate (p < 0.0145) and neurologic outcome (p < 0.006). Variables such as circulatory arrest time (p < 0.24), previous cardiac or aortic operations (p < 0.19), and sex (p < 0.55) failed to show any influence on mortality rate. Permanent neurologic deficits were diagnosed in 12.9% (11/85) of the patients.
  
  
  CONCLUSIONS
  The incidence of permanent neurologic dysfunction as well as the mortality rate are predominantly related to the age of the patient. In this patient group, statistical analysis failed to show a direct correlation between duration of circulatory interruption and neurologic outcome.
authors.affiliation: Clinic of Surgery, Department of Cardio-Thoracic Surgery, University of Vienna, Austria.
authors.forename: M
authors.initials: M
authors.lastname: Grabenwöger
authors.forename: M
authors.initials: M
authors.lastname: Ehrlich
authors.forename: F
authors.initials: F
authors.lastname: Cartes-Zumelzu
authors.forename: M
authors.initials: M
authors.lastname: Mittlböck
authors.forename: G
authors.initials: G
authors.lastname: Weigel
authors.forename: G
authors.initials: G
authors.lastname: Laufer
authors.forename: E
authors.initials: E
authors.lastname: Wolner
authors.forename: M
authors.initials: M
authors.lastname: Havel
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D017545:Aortic Aneurysm, Thoracic / Q000401:mortality / Q000601:surgery*; D005260:Female; D006324:Heart Arrest, Induced; D006801:Humans; D007036:Hypothermia, Induced; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009422:Nervous System Diseases / Q000209:etiology*; D012189:Retrospective Studies; D013997:Time Factors; D014656:Vascular Surgical Procedures / Q000009:adverse effects / Q000401:mortality*