title: [A case of fatal poisoning with the anti-arrhythmia agents Katen and Neo-Gilurytmal].
abstract: The case is presented on 17-year-old student who ingested larger doses of tablets and capsules in privacy. She ingested antiarrhythmics Katen and Neo-Gilurytmal without clinical therapy by these drugs and without history of suicidal attempt. The imminent case of death was asphyxiation by aspiration of vomits from gastric contents after ingestion of excessive doses of drugs. The secondary findings as brain edema, petechiae under the serous membranes and congestion of the abdominal cavity, were relieved at autopsy. Noxae was identified by the postmortem toxicological analysis of blood, liver, kidney, gastric contents and intestinal contents. Mexiletine and prajmaline were analysed by the capillary gas chromatography with FID detection. Retention time of mexiletine was 6.66 minutes, prajmaline 15.15 minutes, respectively. Blood alcohol concentration was 0.21 mg.g-1. Concentration of prajmaline in gastric contents was 3.03 mg.g-1, mexiletine 0.11 mg.g-1, respectively.
authors.affiliation: Súdnolekárske oddelnie NsP, Nitra.
authors.forename: P
authors.initials: P
authors.lastname: Petovský
authors.forename: J
authors.initials: J
authors.lastname: Malý
mesh_terms: D000293:Adolescent; D000889:Anti-Arrhythmia Agents / Q000493:pharmacokinetics / Q000506:poisoning*; D017809:Fatal Outcome; D005260:Female; D005554:Forensic Medicine; D006801:Humans; D008801:Mexiletine / Q000493:pharmacokinetics / Q000506:poisoning*; D011219:Prajmaline / Q000493:pharmacokinetics / Q000506:poisoning*; D014018:Tissue Distribution
chemical_list: D000889:Anti-Arrhythmia Agents; D008801:Mexiletine; D011219:Prajmaline