title: A gene spans the pseudoautosomal boundary in mice.
abstract: The X and Y chromosomes of the mouse, like those of other mammals, are heteromorphic over most of their length, but at the distal ends of the chromosomes is a region of sequence identity, the pseudoautosomal region (PAR), where the chromosomes pair and recombine during male meiosis. The point at which the PAR diverges into X- and Y-specific sequences is called the pseudoautosomal boundary. We have completed a genomic walk from the X-specific Amelogenin gene to the PAR. Analysis of this region revealed that the pseudoautosomal boundary of mice is located within an intron of a transcribed gene that encodes a novel RING finger protein. The first three of the exons of the gene are located on the X chromosome whereas the 3' exons of the gene are located on both X and Y chromosomes. This unusual arrangement may indicate that the gene is in a state of transition from pseudoautosomal to X-unique and provides evidence for a process of attrition of the pseudoautosomal region on the Y chromosome.
authors.affiliation: Cancer Research Campaign Centre for Cell and Molecular Biology, Chester Beatty Laboratories, The Institute of Cancer Research, Fulham Road, London SW3 6JB, United Kingdom.
authors.forename: S
authors.initials: S
authors.lastname: Palmer
authors.forename: J
authors.initials: J
authors.lastname: Perry
authors.forename: D
authors.initials: D
authors.lastname: Kipling
authors.forename: A
authors.initials: A
authors.lastname: Ashworth
mesh_terms: D053523:Amelogenin; D000818:Animals; D016386:Chromosome Walking; D018244:Chromosomes, Artificial, Yeast; D003746:Dental Enamel Proteins / Q000235:genetics; D005260:Female; D018628:Gene Dosage; D015870:Gene Expression; D015723:Gene Library; D007438:Introns; D008297:Male; D051379:Mice / Q000235:genetics*; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D011506:Proteins / Q000235:genetics*; D012091:Repetitive Sequences, Nucleic Acid; D017422:Sequence Analysis, DNA; D016324:Sequence Tagged Sites; D012730:Sex Chromosomes; D014018:Tissue Distribution; D044767:Ubiquitin-Protein Ligases; D014960:X Chromosome; D014998:Y Chromosome
chemical_list: D053523:Amelogenin; C507200:Amelx protein, mouse; D003746:Dental Enamel Proteins; D011506:Proteins; C109037:Mid1 protein, mouse; D044767:Ubiquitin-Protein Ligases