title: Neurotrophic activity of organosulfur compounds having a thioallyl group on cultured rat hippocampal neurons.
abstract: Several organosulfur compounds found in garlic extract promoted the survival of rat hippocampal neurons in vitro. From the analysis of structure-activity relationship, thioallyl group in these compounds is essential for the manifestation of neurotrophic activity. S-Allyl-L-cysteine (SAC), one of the organosulfur compounds having thioallyl group in garlic extract, also promoted the axonal branching of cultured neurons. These results suggest that thioallyl compounds make a unique group of neurotrophic factors.
authors.affiliation: Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Moriguchi
authors.forename: H
authors.initials: H
authors.lastname: Matsuura
authors.forename: Y
authors.initials: Y
authors.lastname: Kodera
authors.forename: Y
authors.initials: Y
authors.lastname: Itakura
authors.forename: H
authors.initials: H
authors.lastname: Katsuki
authors.forename: H
authors.initials: H
authors.lastname: Saito
authors.forename: N
authors.initials: N
authors.lastname: Nishiyama
mesh_terms: D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D003545:Cysteine / Q000031:analogs & derivatives / Q000502:physiology; D004622:Embryo, Mammalian; D005737:Garlic / Q000737:chemistry / Q000502:physiology; D006624:Hippocampus / Q000166:cytology / Q000187:drug effects*; D009414:Nerve Growth Factors / Q000502:physiology*; D009474:Neurons / Q000187:drug effects*; D010946:Plants, Medicinal; D051381:Rats; D017208:Rats, Wistar; D013455:Sulfur / Q000502:physiology*
chemical_list: D009414:Nerve Growth Factors; D013455:Sulfur; C006453:alliin; C065299:S-allylcysteine; D003545:Cysteine