title: Early high-dose intravenous methylprednisolone in acute disseminated encephalomyelitis: a successful recovery.
abstract: We describe a patient with acute disseminated encephalomyelitis (ADEM) who was treated with high-dose intravenous methylprednisolone 2 days after onset of neurologic symptoms. Despite poor prognostic factors and extensive white matter lesions, the patient recovered dramatically with no need for maintenance steroid therapy. This case report of fulminant ADEM treated successfully with early high-dose intravenous methylprednisolone, although uncontrolled, suggests that this agent should be studied in other cases.
authors.affiliation: Department of Internal Medicine, University Hospital of Geneva, Switzerland.
authors.forename: J
authors.initials: J
authors.lastname: Straub
authors.forename: M
authors.initials: M
authors.lastname: Chofflon
authors.forename: J
authors.initials: J
authors.lastname: Delavelle
mesh_terms: D000328:Adult; D000893:Anti-Inflammatory Agents / Q000009:adverse effects* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004673:Encephalomyelitis, Acute Disseminated / Q000175:diagnosis / Q000188:drug therapy*; D006801:Humans; D007275:Injections, Intravenous; D008279:Magnetic Resonance Imaging; D008297:Male; D008775:Methylprednisolone / Q000009:adverse effects* / Q000627:therapeutic use; D012074:Remission Induction
chemical_list: D000893:Anti-Inflammatory Agents; D008775:Methylprednisolone