Combined neuroendocrine carcinoma of the skin (Merkel cell tumor) and trichilemmal cyst.
We report a case of neuroendocrine (Merkel cell) carcinoma (NC) of the skin, associated with a trichilemmal cyst, showing pagetoid spread into the trichilemmal epithelium. The association of the two lesions may strengthen the hypothesis that NC originates from pluripotent stem cells of adnexal epithelium.
Collina
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Sezione di Anatomia Patologica, Dipartimento di Scienze Morfologiche e Medico Legali, Università di Modena, Italy.
Bagni
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Fano
R A
RA
D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D015266:Carcinoma, Merkel Cell / Q000473:pathology*; D002466:Cell Nucleolus / Q000648:ultrastructure; D002467:Cell Nucleus / Q000648:ultrastructure; D002843:Chromatin / Q000648:ultrastructure; D003593:Cytoplasm / Q000648:ultrastructure; D004814:Epidermal Cyst / Q000473:pathology*; D004848:Epithelium / Q000473:pathology; D005260:Female; D006801:Humans; D007633:Keratins / Q000032:analysis; D014411:Neoplastic Stem Cells / Q000473:pathology; D016900:Neurofilament Proteins / Q000032:analysis; D010751:Phosphopyruvate Hydratase / Q000032:analysis; D012867:Skin / Q000473:pathology; D012871:Skin Diseases / Q000473:pathology*; D012878:Skin Neoplasms / Q000473:pathology*
D014408:Biomarkers, Tumor; D002843:Chromatin; D016900:Neurofilament Proteins; D007633:Keratins; D010751:Phosphopyruvate Hydratase