Dietary fat clearance in normal subjects is modulated by genetic variation at the apolipoprotein B gene locus.
Apolipoprotein B (apo B) plays a dominant role in cholesterol homeostasis. Several polymorphic sites within or adjacent to the gene locus for apo B have been detected. The X+ allele (XbaI restriction site present) of the XbaI restriction fragment polymorphism on the apo B gene has been found in some studies to be associated with higher serum cholesterol and/or triglyceride levels and with greater dietary response. The present study was designed to evaluate whether the apo B XbaI polymorphism was associated with the interindividual variability observed during postprandial lipemia. Fifty-one healthy young male volunteers [20 X-/X- (X-), and 31 X+/X- or X+/X+ (X+)], homozygotes for the apo E3 allele, were subjected to a vitamin A-fat load test. Subjects with the X- genotype had significantly greater retinyl palmitate (RP) and apo B-48 postprandial responses on both the large and the small TRL lipoprotein fractions compared with X+ subjects. In summary, subjects with the X-/X- genotype at the apo B locus have a greater postprandial response than X+ subjects. These differences observed in postprandial lipoprotein metabolism could explain some of the reported associations of this polymorphism to coronary heart disease risk.
Lopez-Miranda
J
J
Unidad de Lipidos y Arteriosclerosis, Hospital Universitario Reina Sofia, Cordoba, Spain.
Ordovas
J M
JM
Ostos
M A
MA
Marin
C
C
Jansen
S
S
Salas
J
J
Blanco-Molina
A
A
Jimenez-Pereperez
J A
JA
Lopez-Segura
F
F
Perez-Jimenez
F
F
D000293:Adolescent; D000328:Adult; D000483:Alleles; D053283:Apolipoprotein B-48; D053318:Apolipoprotein E3; D001053:Apolipoproteins / Q000235:genetics*; D001055:Apolipoproteins B / Q000097:blood; D001057:Apolipoproteins E / Q000235:genetics; D002874:Chromosome Mapping; D004041:Dietary Fats / Q000493:pharmacokinetics* / Q000494:pharmacology; D004224:Diterpenes; D004435:Eating / Q000502:physiology; D014644:Genetic Variation / Q000502:physiology*; D006801:Humans; D008074:Lipoproteins / Q000097:blood; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000502:physiology; D012016:Reference Values; D000084562:Retinyl Esters; D014280:Triglycerides / Q000097:blood; D014801:Vitamin A / Q000031:analogs & derivatives / Q000097:blood
D053283:Apolipoprotein B-48; D053318:Apolipoprotein E3; D001053:Apolipoproteins; D001055:Apolipoproteins B; D001057:Apolipoproteins E; D004041:Dietary Fats; D004224:Diterpenes; D008074:Lipoproteins; D000084562:Retinyl Esters; D014280:Triglycerides; C049537:apolipoprotein G; D014801:Vitamin A; C014794:retinol palmitate