title: Cellular effects of individual high-linear energy transfer particles and implications for tissue response at low doses.
abstract: The energy deposition patterns produced by the radiation environment in space can be quite different from those in conventional radiation environments. Furthermore, conventional radiation biological experiments, using randomly distributed particle tracks, cannot access some variables which may be important in determining the health effects of irradiation. Controlled microbeam irradiation provides the means to investigate the effects and unique energy deposition patterns and cell environment for a variety of end points.
authors.affiliation: Texas A&M University, College of Engineering, Department of Nuclear Engineering, College Station 77843-3133, USA.
authors.forename: L A
authors.initials: LA
authors.lastname: Braby
authors.forename: A L
authors.initials: AL
authors.lastname: Brooks
authors.forename: N F
authors.initials: NF
authors.lastname: Metting
mesh_terms: D000512:Alpha Particles; D000818:Animals; D002478:Cells, Cultured / Q000528:radiation effects; D002869:Chromosome Aberrations; D002875:Chromosomes / Q000528:radiation effects*; D004249:DNA Damage / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D005720:Gamma Rays; D006801:Humans; D018499:Linear Energy Transfer; D008722:Methods; D015162:Micronucleus Tests; D013026:Space Flight