Immunosuppressive effects of gallic acid and chebulagic acid on CTL-mediated cytotoxicity.
Gallic acid (GA) and chebulagic acid (CA) were isolated from the extract of a herbal medicine, kashi (myrobalans: the fruit of Terminalia chebula) as active principles that blocked the cytotoxic T lymphocyte (CTL)-mediated cytotoxicity. GA and CA inhibited the killing activity of CD8+ CTL clone at IC50 values of 30 microM and 50 microM, respectively. Granule exocytosis in response to anti-CD3 stimulation was also blocked by GA and CA at the equivalent concentrations.
Hamada
S
S
Department of Bioengineering, Tokyo Institute of Technology, Yokohama, Japan.
Kataoka
T
T
Woo
J T
JT
Yamada
A
A
Yoshida
T
T
Nishimura
T
T
Otake
N
N
Nagai
K
K
D000818:Animals; D001578:Benzopyrans / Q000302:isolation & purification / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D002999:Clone Cells; D004791:Enzyme Inhibitors / Q000302:isolation & purification / Q000494:pharmacology*; D005707:Gallic Acid / Q000302:isolation & purification / Q000494:pharmacology*; D005960:Glucosides / Q000302:isolation & purification / Q000494:pharmacology*; D051379:Mice; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*
D001578:Benzopyrans; D004791:Enzyme Inhibitors; D005960:Glucosides; D010936:Plant Extracts; C076178:chebulagic acid; D005707:Gallic Acid