Intra-hippocampal estradiol infusion enhances memory in ovariectomized rats.
Ovariectomized adult Long-Evans rats received an eight-trial training session in a hippocampal-dependent hidden platform water maze task. Following trial 8, rats received an intra-hippocampal injection of estradiol in a water soluble cyclodextrin inclusion complex (1.0, 2.0 or 5.0 micrograms/0.5 microliter), or saline. Twenty-four hours later, the retention test escape latencies of rats administered post-training intra-hippocampal injections of estradiol (5.0 micrograms) were significantly lower than those of saline treated rats, indicating a memory-enhancing effect of estradiol. Injections of estradiol (5.0 micrograms) given 2 h post-training had no effect on retention, indicating a time-dependent effect of estradiol on memory storage processes.
Packard
M G
MG
Department of Psychology, University of New Orleans, LA 70148, USA.
Teather
L A
LA
D000704:Analysis of Variance; D000818:Animals; D001345:Autoradiography; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D006624:Hippocampus / Q000166:cytology / Q000187:drug effects*; D018782:Maze Learning / Q000502:physiology*; D008568:Memory / Q000187:drug effects*; D009474:Neurons / Q000187:drug effects*; D010052:Ovariectomy; D010053:Ovary / Q000502:physiology*; D051381:Rats
D004958:Estradiol