Reactivation of Epstein-Barr virus: regulation and function of the BZLF1 gene.
The switch from latent infection to virus replication in Epstein-Barr virus (EBV)-infected B cells is initiated by expression of the viral BZLF1 gene. Recent studies have identified the key cellular transcription factors involved in regulating this switch in viral programs and the signal transduction pathways to which they respond. Understanding this switch may facilitate development of strategies to interfere with EBV infection.
Speck
S H
SH
Dept of Pathology, Washington University School of Medicine, St Louis, MO 63110, USA. speck@pathology.wustl.edu
Chatila
T
T
Flemington
E
E
D000818:Animals; D004268:DNA-Binding Proteins / Q000235:genetics*; D015967:Gene Expression Regulation, Viral; D005814:Genes, Viral; D004854:Herpesvirus 4, Human / Q000235:genetics* / Q000254:growth & development*; D006801:Humans; D015534:Trans-Activators / Q000235:genetics*; D014764:Viral Proteins; D015678:Viral Structural Proteins / Q000235:genetics*; D014775:Virus Activation
C063676:BZLF1 protein, Herpesvirus 4, Human; D004268:DNA-Binding Proteins; D015534:Trans-Activators; D014764:Viral Proteins; D015678:Viral Structural Proteins