title: Changes in cyclosporine A kinetics after experimental reduction of renal parenchyma.
abstract: Experimental chronic renal insufficiency (produced by 5/6 ablation of renal parenchyma) is associated with changes in the kinetics of oral (intragastric) cyclosporine A (CyA). Compared with animals with intact renal parenchyma, significantly lower levels of CyA are reached under these conditions. The factors responsible for reduced CyA availability under these conditions have not yet been identified.
authors.affiliation: Institute for Clinical and Experimental Medicine, Prague, Czech Republic.
authors.forename: O
authors.initials: O
authors.lastname: Schück
authors.forename: M
authors.initials: M
authors.lastname: Bohdanecká
authors.forename: J
authors.initials: J
authors.lastname: Sedivý
authors.forename: M
authors.initials: M
authors.lastname: Krajícková
authors.forename: M
authors.initials: M
authors.lastname: Chadimová
authors.forename: K
authors.initials: K
authors.lastname: Matousovic
mesh_terms: D000818:Animals; D016572:Cyclosporine / Q000097:blood / Q000493:pharmacokinetics*; D007166:Immunosuppressive Agents / Q000097:blood / Q000493:pharmacokinetics*; D007668:Kidney / Q000378:metabolism*; D008297:Male; D009392:Nephrectomy / Q000379:methods*; D051381:Rats; D051437:Renal Insufficiency / Q000378:metabolism; D013997:Time Factors
chemical_list: D007166:Immunosuppressive Agents; D016572:Cyclosporine