Induction of HIV-1 specific mucosal immune responses by DNA vaccination.
DNA vaccination has been shown to induce immunity against several different pathogens including HIV-1. The authors demonstrate here that administration of DNA vaccines via the intranasal route is sufficient to induce immune responses both at distal mucosal sites and systemically. Since transmission of HIV-1 occurs largely across mucosal surfaces, the intranasal route provides a further means of application for DNA immunization.
Asakura
Y
Y
Microbiology and Tumor Biology Center, Karolinska Institute, Stockholm, Sweden.
Hinkula
J
J
Leandersson
A C
AC
Fukushima
J
J
Okuda
K
K
Wahren
B
B
D000281:Administration, Intranasal; D000818:Animals; D000956:Antigens, Viral / Q000276:immunology; D000939:Epitopes / Q000276:immunology; D015483:HIV Antibodies / Q000096:biosynthesis*; D015497:HIV-1 / Q000276:immunology*; D018928:Immunity, Mucosal; D007070:Immunoglobulin A / Q000096:biosynthesis; D007074:Immunoglobulin G / Q000096:biosynthesis; D008213:Lymphocyte Activation; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D019444:Vaccines, DNA / Q000008:administration & dosage / Q000276:immunology*
D000956:Antigens, Viral; D000939:Epitopes; D015483:HIV Antibodies; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D019444:Vaccines, DNA