Cytokeratin and vimentin expression in normal epithelium and squamous cell carcinomas of the larynx.
The immunohistochemical expression patterns of cytokeratin polypeptides and vimentin were investigated in normal epithelia and squamous cell carcinomas of the larynx with special emphasis on tumor grading. During malignant transformation of epithelial cells, the cytokeratin expression patterns changed, depending on the differentiation grade of the carcinomas. In low-grade carcinomas, the expression patterns were close to those of the normal epithelium. With increasing tumor grade, there was decreased expression of stratification cytokeratins and increased expression of basal cell, simple cell and hyperproliferation-related cytokeratins. Increasing tumor grade was also associated with the expression of vimentin, a cytoskeletal protein of mesenchymal cells. No relationship was found between vimentin expression and the presence of lymph-node metastases.
van der Velden
L A
LA
Department of Otorhinolaryngology, University Hospital Nijmegen, The Netherlands.
Schaafsma
H E
HE
Manni
J J
JJ
Ruiter
D J
DJ
Ramaekers
F C
FC
Kuijpers
W
W
D014408:Biomarkers, Tumor / Q000032:analysis*; D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D002455:Cell Division / Q000502:physiology; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D004848:Epithelium / Q000473:pathology; D006801:Humans; D007633:Keratins / Q000032:analysis*; D007822:Laryngeal Neoplasms / Q000473:pathology*; D007830:Larynx / Q000473:pathology; D008207:Lymphatic Metastasis; D009367:Neoplasm Staging; D011379:Prognosis; D012016:Reference Values; D014746:Vimentin / Q000032:analysis*
D014408:Biomarkers, Tumor; D014746:Vimentin; D007633:Keratins