title: Haematopoietic reconstitution after autologous transplantation of CD34(+)-selected versus non-selected peripheral blood progenitor cells.
abstract: Selection of CD34+ cells for autologous transplantation is increasingly being used to reduce potential tumor cell contamination of the autograft. Haematopoietic reconstitution in 40 patients after transplantation of CD34(+)-selected versus non-selected G-CSF-mobilized PBPC was compared and was almost identical in the two groups of patients. Delayed platelet engraftment was only observed in patients transplanted with a CD34+ cell dose of < 2.5 x 10(6)/kg body weight. It has to be shown whether the positive selection of CD34+ cells will improve the disease free survival after autologous PBPC transplantation.
authors.affiliation: Department of Transfusion Medicine, University of Ulm, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Wiesneth
authors.forename: T
authors.initials: T
authors.lastname: Schreiner
authors.forename: M
authors.initials: M
authors.lastname: Sandherr
authors.forename: B
authors.initials: B
authors.lastname: Maccari
authors.forename: E
authors.initials: E
authors.lastname: Erne
authors.forename: C
authors.initials: C
authors.lastname: Bischof
authors.forename: N
authors.initials: N
authors.lastname: Frickhofen
authors.forename: C
authors.initials: C
authors.lastname: von Schilling
authors.forename: B
authors.initials: B
authors.lastname: Kubanek
mesh_terms: D000293:Adolescent; D000328:Adult; D018952:Antigens, CD34 / Q000097:blood*; D005260:Female; D000069585:Filgrastim; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage; D019650:Hematopoietic Stem Cell Mobilization / Q000379:methods*; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000097:blood / Q000628:therapy*; D010976:Platelet Count; D011994:Recombinant Proteins; D016896:Treatment Outcome
chemical_list: D018952:Antigens, CD34; D011994:Recombinant Proteins; D016179:Granulocyte Colony-Stimulating Factor; D000069585:Filgrastim