title: Precocious pseudopuberty due to a granulosa cell tumour in a seven-month-old female.
abstract: We describe a juvenile granulosa cell tumour resulting in pseudopuberty in an infant female. The progression of the clinical signs of puberty were non-consonant and the diagnosis was complicated by marginally elevated serum alpha-fetoprotein levels. The histological appearance of the resected tumour and binding of MIC2 antibody to tumour cells confirmed the diagnosis.
authors.affiliation: Department of Endocrinology, Great Ormond Street Hospital for Sick Children NHS Trust, London, UK.
authors.forename: F J
authors.initials: FJ
authors.lastname: Cameron
authors.forename: I
authors.initials: I
authors.lastname: Scheimberg
authors.forename: R
authors.initials: R
authors.lastname: Stanhope
mesh_terms: D003937:Diagnosis, Differential; D004958:Estradiol / Q000097:blood; D005260:Female; D005500:Follow-Up Studies; D006106:Granulosa Cell Tumor / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D006801:Humans; D007223:Infant; D010051:Ovarian Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D010053:Ovary / Q000473:pathology; D011629:Puberty, Precocious / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D000509:alpha-Fetoproteins / Q000378:metabolism
chemical_list: D000509:alpha-Fetoproteins; D004958:Estradiol