Membrane-linked systems preventing superoxide formation.
New facts and ideas concerning the membrane-linked mechanisms preventing superoxide formation are summarised here. It is assumed that aerobic cells possess several lines of anti-ROS defence, including optimisation of the intracellular oxygen concentration, decrease in the concentration and life-time of one-electron O2 reductants such as CoQH; and mitochondrial and cell selections, i.e. elimination of mitochondria and cells producing ROS at high rate. It is postulated that ROS-dependent pore opening and ROS-dependent apoptosis are involved in mitochondrial and cell selections.
Skulachev
V P
VP
Department of Bioenergetics, A. N. Belozersky Institute of Physico-Chemical Biology, Moscow State University, Russia.
D000154:Aconitate Hydratase / Q000378:metabolism; D000818:Animals; D017209:Apoptosis; D001395:Azotobacter / Q000378:metabolism; D001419:Bacteria / Q000378:metabolism; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism*; D002463:Cell Membrane Permeability; D004272:DNA, Mitochondrial / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D008928:Mitochondria / Q000378:metabolism; D010084:Oxidation-Reduction; D010539:Permeability; D010944:Plants / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism*; D013481:Superoxides / Q000378:metabolism*; D014475:Uncoupling Agents / Q000378:metabolism / Q000494:pharmacology
D004272:DNA, Mitochondrial; D017382:Reactive Oxygen Species; D014475:Uncoupling Agents; D013481:Superoxides; D000154:Aconitate Hydratase