CMV-induced anti-Sia-b1 cold agglutinin in an immunocompromised patient.
In postinfection cold agglutination, certain cold agglutinin (CA) specificities are associated with distinct infectious agents. The combined occurrence of anti-I and anti-Sia-b1 CAs following Mycoplasma pneumoniae infection has been reported recently. After renal transplantation and hyperacute graft rejection, transiently occurring CAs were observed in an 18-year-old boy. The CAs were characterized by serum cold absorption with sialidase-treated red cells and warm elution from the cells. An anti-Sia-b1 CA could be differentiated from an accompanying low-liter anti-I. Fresh infections with Mycoplasma pneumoniae, Epstein-Barr virus, rubella, and varicella viruses were excluded, but CMV infection was demonstrated. This is the first case of a postinfection anti-Sia-b1 CA associated with CMV infection.
Zilow
G
G
Institut für Immunologie, Ruprecht-Karls-Universität Heidelberg, Germany.
Haffner
D
D
Roelcke
D
D
D000293:Adolescent; D000373:Agglutinins / Q000097:blood*; D000918:Antibody Specificity / Q000276:immunology; D003298:Coombs Test; D003450:Cryoglobulins; D003587:Cytomegalovirus / Q000276:immunology*; D003586:Cytomegalovirus Infections / Q000276:immunology*; D017707:Erythrocyte Transfusion; D006084:Graft Rejection / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007519:Isoantigens / Q000276:immunology*; D007676:Kidney Failure, Chronic / Q000276:immunology*; D016030:Kidney Transplantation / Q000276:immunology; D008297:Male; D009894:Opportunistic Infections / Q000276:immunology*; D012795:Sialoglycoproteins / Q000276:immunology*
D000373:Agglutinins; D003450:Cryoglobulins; D007074:Immunoglobulin G; D007519:Isoantigens; D012795:Sialoglycoproteins; C029443:cold agglutinins