title: Juvenile chronic arthritis--bone mineral density in relation to corticosteroid therapy.
abstract: Bone demineralization often accompanies juvenile chronic arthritis (JCA). Fourteen patients with confirmed diagnosis of JCA had their bone mineral density (BMD) measured with the use of dual photon X-ray absorptiometry. The results obtained were compared to the Lunar BMD DPXA standards. Seven patients received Prednisone in doses of more than 0.16 mg/kg/day for more than 6 months and 7 patients (sex and age matched) never received any steroids at all. In the first group BMD was decreased in 7 patients (100%), in the second group BMD was mildly decreased in 2 patients (28%). Due to the difference in BMD in both groups, it is obvious that corticosteroids have substantial influence on bone demineralization in JCA.
authors.affiliation: Department of Paediatrics, First Medical Faculty, Charles University, Prague, Czech Republic.
authors.forename: M
authors.initials: M
authors.lastname: Bayer
authors.forename: J
authors.initials: J
authors.lastname: Stĕpán
authors.forename: D
authors.initials: D
authors.lastname: Nĕmcová
authors.forename: S
authors.initials: S
authors.lastname: Kutílek
authors.forename: J
authors.initials: J
authors.lastname: Hoza
mesh_terms: D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000009:adverse effects*; D000328:Adult; D001171:Arthritis, Juvenile / Q000188:drug therapy* / Q000378:metabolism*; D015519:Bone Density / Q000187:drug effects*; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D012189:Retrospective Studies
chemical_list: D000305:Adrenal Cortex Hormones