title: Serum free thyroxine concentration is not reduced in premature infants with respiratory distress syndrome.
abstract: OBJECTIVE
  We used improved methods of assay to determine whether pituitary-thyroid function is altered in premature infants with respiratory distress syndrome (RDS) during the first week of postnatal life.
  
  
  METHODS
  Serum free thyroxine (T4) was measured by direct equilibrium dialysis, total thyroxine (TT4) by radioimmunoassay, and thyrotropin by a sensitive immunometric assay in 90 premature infants (45 healthy control subjects and 45 with RDS) during their first week of life after 25 to 30 weeks of gestation. Infants in the RDS group received exogenous surfactant therapy.
  
  
  RESULTS
  Free T4 and thyrotropin concentrations of infants were not significantly different between RDS and control groups. As expected, infants with RDS had significantly lower serum total T4 concentrations compared with control infants (p < 0.001). This difference was present even after stratification for gestational age (25- to 27-week group, p = 0.012; 28- to 30-week group, p = 0.002). Lower total T4 concentrations were attributable to lower T4 binding to serum proteins among infants with RDS compared with control subjects, especially in the 25- to 27-week gestation group (p = 0.0075).
  
  
  CONCLUSIONS
  These data indicate that pituitary-thyroid function is not altered in premature infants with RDS. The low total T4 state in these premature infants is attributable solely to reduced serum T4 binding, as is often seen in acute nonthyroidal illnesses.
authors.affiliation: Department of Pediatrics, Loma Linda University School of Medicine, CA 92350, USA.
authors.forename: L
authors.initials: L
authors.lastname: Job
authors.forename: J R
authors.initials: JR
authors.lastname: Emery
authors.forename: A O
authors.initials: AO
authors.lastname: Hopper
authors.forename: D D
authors.initials: DD
authors.lastname: Deming
authors.forename: G A
authors.initials: GA
authors.lastname: Nystrom
authors.forename: S J
authors.initials: SJ
authors.lastname: Clark
authors.forename: J C
authors.initials: JC
authors.lastname: Nelson
mesh_terms: D016022:Case-Control Studies; D003956:Dialysis; D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D011663:Pulmonary Surfactants / Q000627:therapeutic use; D011863:Radioimmunoassay; D012127:Respiratory Distress Syndrome, Newborn / Q000097:blood* / Q000188:drug therapy; D013972:Thyrotropin / Q000097:blood*; D013974:Thyroxine / Q000097:blood*
chemical_list: D011663:Pulmonary Surfactants; D013972:Thyrotropin; D013974:Thyroxine