title: Structure of the receptor binding fragment HC of tetanus neurotoxin.
abstract: The 2.7 A structure of the tetanus neurotoxin receptor binding fragment Hc reveals a jelly-roll domain and a beta-trefoil domain. Hc retains the unique transport properties of the holotoxin and is capable of eliciting a protective immunological response against the full length holotoxin.
authors.forename: T C
authors.initials: TC
authors.lastname: Umland
authors.forename: L M
authors.initials: LM
authors.lastname: Wingert
authors.forename: S
authors.initials: S
authors.lastname: Swaminathan
authors.forename: W F
authors.initials: WF
authors.lastname: Furey
authors.forename: J J
authors.initials: JJ
authors.lastname: Schmidt
authors.forename: M
authors.initials: M
authors.lastname: Sax
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D003198:Computer Simulation; D018360:Crystallography, X-Ray; D008565:Membrane Proteins / Q000737:chemistry* / Q000378:metabolism; D008958:Models, Molecular; D008961:Models, Structural; D008969:Molecular Sequence Data; D009474:Neurons / Q000378:metabolism; D010446:Peptide Fragments / Q000737:chemistry / Q000276:immunology; D017433:Protein Structure, Secondary; D017384:Sequence Deletion; D012984:Software; D013744:Tetanus Toxin / Q000737:chemistry* / Q000276:immunology
chemical_list: D008565:Membrane Proteins; D010446:Peptide Fragments; D013744:Tetanus Toxin; C028728:tetanus toxin receptor