title: The beta subunit, Kv beta 1.2, acts as a rapid open channel blocker of NH2-terminal deleted Kv1.4 alpha-subunits.
abstract: A recently discovered class of ancillary subunits has been shown to modify the inactivation properties of alpha-subunits belonging to the Kv1 family of potassium channels. One of these subunits, Kv beta 1.2, modifies intrinsic alpha-subunit C-type inactivation. N-type inactivation and open channel block have been proposed to increase the rate of development of C-type inactivation. We demonstrate here that Kv beta 1.2 has kinetic properties which are consistent with rapid open channel block.
authors.affiliation: Department of Biomedical Engineering, School of Engineering, Duke University, Durham, NC 27708, USA.
authors.forename: R L
authors.initials: RL
authors.lastname: Rasmusson
authors.forename: S
authors.initials: S
authors.lastname: Wang
authors.forename: R C
authors.initials: RC
authors.lastname: Castellino
authors.forename: M J
authors.initials: MJ
authors.lastname: Morales
authors.forename: H C
authors.initials: HC
authors.lastname: Strauss
mesh_terms: D000818:Animals; D003198:Computer Simulation; D004553:Electric Conductivity; D005289:Ferrets; D015640:Ion Channel Gating / Q000502:physiology; D007700:Kinetics; D051663:Kv1.2 Potassium Channel; D051665:Kv1.4 Potassium Channel; D046911:Macromolecular Substances; D015221:Potassium Channels / Q000737:chemistry / Q000502:physiology*; D024642:Potassium Channels, Voltage-Gated
chemical_list: D051663:Kv1.2 Potassium Channel; D051665:Kv1.4 Potassium Channel; D046911:Macromolecular Substances; D015221:Potassium Channels; D024642:Potassium Channels, Voltage-Gated