Permeability of contrast media through hemodialysis membrane.
OBJECTIVE
To compare the permeability of 10 contrast media (CM) through the hemodialysis membrane.


METHODS
An experimental model was constructed from clinical hemodialysis equipment. The 10 CM that were used were: diatrizoate, iothalamate, iopamidol, iohexol, iopromide, ioversol, iomeprol, ioxaglate, iodixanol and iotrolan. They were dissolved into the dialysate. Each solution ran into the blood circuit of the dialyzer at a rate of 200 ml/min and into the dialysate circuit of the dialysis machine at a rate of 500 ml/min. Permeability was expressed as clearance, calculated from the iodine concentration at the afferent and efferent lines of the dialyzer, and from the blood-flow rate.


RESULTS
The clearance of all the monomeric CM was superior to that of all the dimeric CM. Values of clearance and molecular weight correlated well.


CONCLUSIONS
The molecular weight of a contrast medium is the main factor that influences the efficiency of CM removal by hemodialysis.
Furukawa
T
T
Department of Radiology, Sumitomo Hospital, Osaka, Japan.
Ueda
J
J
Higashino
K
K
Takahashi
S
S
Sakaguchi
K
K
Imai
T
T
D002482:Cellulose / Q000031:analogs & derivatives; D003287:Contrast Media / Q000737:chemistry*; D008567:Membranes, Artificial; D008970:Molecular Weight; D009994:Osmolar Concentration; D010539:Permeability; D006435:Renal Dialysis / Q000295:instrumentation*
D003287:Contrast Media; D008567:Membranes, Artificial; D002482:Cellulose; C026170:cellulose diacetate