title: Antiemetic inhibits conditioned taste aversion, but not the hypophagia induced by epinephrine.
abstract: It has been shown that relatively high doses of epinephrine (E) injected intraperitoneally (IP) produce hypophagia and conditioned taste aversion (CTA) in rats. We examined the possibility that E effects involve malaise. For this purpose, changes in saccharin preference induced by E injected IP (100 microg/kg) were determined after a previous administration of trimethobenzamide (TMB, 5 mg/kg), an antiemetic agent. E alone decreased saccharin preference by 54% (p < 0.01), but only by 16% (not significant) in the presence of TMB. In contrast, the injection of 75 or 100 microg/kg E reduced food intake by 50 and 85%, respectively (p < 0.01), regardless of previous injection of TMB. In conclusion, the results suggest that E-induced malaise is not the direct cause of the hypophagia it elicits.
authors.affiliation: División de Biología Marina, Centro de Investigaciones Biológicas del Noroeste, La Paz, BCS, México.
authors.forename: I S
authors.initials: IS
authors.lastname: Racotta
authors.forename: R
authors.initials: R
authors.lastname: Arzuffi
authors.forename: I
authors.initials: I
authors.lastname: Garduño
authors.forename: R
authors.initials: R
authors.lastname: Racotta
mesh_terms: D000818:Animals; D000932:Antiemetics / Q000494:pharmacology*; D001245:Association Learning / Q000187:drug effects*; D001362:Avoidance Learning / Q000187:drug effects*; D001549:Benzamides / Q000494:pharmacology*; D003214:Conditioning, Classical / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004435:Eating / Q000187:drug effects*; D004837:Epinephrine / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D008297:Male; D009042:Motivation; D051381:Rats; D017208:Rats, Wistar; D013649:Taste / Q000187:drug effects*
chemical_list: D000932:Antiemetics; D001549:Benzamides; C100146:trimethobenzamide; D004837:Epinephrine