Primary HIV infection: follow-up of patients initially randomized to zidovudine or placebo.
A randomized trial of 77 patients with primary HIV infection concluded that a 6-month course of zidovudine significantly reduced the incidence of opportunistic infections and improved CD4 cell counts. Follow-up was extended over a mean of 28 months to assess whether these benefits persisted beyond the trial period under conditions of routine care. In the post-trial period, antiviral drugs were prescribed with similar frequency in the zidovudine (248 treatment days per patient) and placebo arms (239 days, P=0.59). At the end of follow-up, patients initially assigned to zidovudine had still accumulated fewer disease progression events (three) than those given placebo (eight), but contrary to the initial analysis, the difference was no longer statistically significant (logrank test, P=0.07). The incidence of progression events tended to increase over time in the zidovudine group, and to decrease in the placebo group (trends tested in Weibull survival models, P=0.04). Similarly, initial gains in CD4 counts in the zidovudine arm diminished progressively after the trial, as CD4 counts declined faster in this group than in placebo-treated patients (-5.0 vs. -3.2 cells/mm3/month, P=0.06). In summary, initial clinical and immunological benefits of a 6-month course of zidovudine in patients with primary HIV infection eroded over time, suggesting that longer and more potent antiviral treatment should be given consideration.
Kinloch-de Loës
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Division of Infectious Diseases, Geneva University Hospitals, Switzerland.
Perneger
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TV
D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D018791:CD4 Lymphocyte Count; D005500:Follow-Up Studies; D015658:HIV Infections / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D015497:HIV-1; D006801:Humans; D018894:Reverse Transcriptase Inhibitors / Q000627:therapeutic use*; D015215:Zidovudine / Q000627:therapeutic use*
D019380:Anti-HIV Agents; D018894:Reverse Transcriptase Inhibitors; D015215:Zidovudine