title: Results of a pilot study of endoscopic screening of first degree relatives of colorectal cancer patients in Italy.
abstract: OBJECTIVE
  Screening recommendations for colorectal cancer include sigmoidoscopy in asymptomatic, average risk persons aged 50 and over and colonoscopy every three to five years in high risk groups. Little is known about the eligible population's compliance with endoscopic screening. This is the first Italian report of an endoscopic screening programme for colorectal cancer patients' relatives.
  
  
  METHODS
  In 1986, a pilot project for colorectal cancer screening by endoscopy in high risk subjects was started in the Desio (Milan, Italy) public health service region. The results obtained after seven years are described.
  
  
  METHODS
  The names of 536 inhabitants with colorectal cancer diagnosed between January 1975 and December 1984 and their relatives' addresses were obtained from the Regione Lombardia Health System records and from the municipal registry offices respectively.
  
  
  METHODS
  From October 1986 to October 1993, 778 first degree relatives aged 20-75 were offered colonoscopy.
  
  
  RESULTS
  After seven years, 233 (29.9%) had undergone endoscopic examination, mostly up to the splenic flexure. Being > 60 in age at the start of the programme negatively affected the participation (p < 0.05). Two cancers were detected and adenomatous polyps were found in another 24 of those screened (frequencies 0.9% and 10.3% respectively). Male gender (p < 0.05), increasing age in males (p < 0.01), and two or more affected relatives in females (p < 0.01) positively affected the frequency of polyps detection.
  
  
  CONCLUSIONS
  These results suggest that about 30% of the eligible population would comply at least with sigmoidoscopic screening. The collaboration of family doctors and more widespread public information about the ability to cure colorectal cancer are necessary for better compliance.
authors.affiliation: University Department of Clinical Pathology, Hospital of Desio, Milan, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Colombo
authors.forename: G
authors.initials: G
authors.lastname: Corti
authors.forename: F
authors.initials: F
authors.lastname: Magrì
authors.forename: A
authors.initials: A
authors.lastname: Marocchi
authors.forename: P
authors.initials: P
authors.lastname: Brambilla
authors.forename: C
authors.initials: C
authors.lastname: Crespi
authors.forename: L
authors.initials: L
authors.lastname: Manieri
authors.forename: S
authors.initials: S
authors.lastname: Ghezzi
authors.forename: D
authors.initials: D
authors.lastname: Giannone
authors.forename: L
authors.initials: L
authors.lastname: Merlino
authors.forename: P
authors.initials: P
authors.lastname: Mocarelli
mesh_terms: D011125:Adenomatous Polyposis Coli / Q000175:diagnosis; D000328:Adult; D000367:Age Factors; D000368:Aged; D003113:Colonoscopy; D015179:Colorectal Neoplasms / Q000517:prevention & control*; D005192:Family Health; D005260:Female; D006801:Humans; D007558:Italy; D008297:Male; D008403:Mass Screening; D008875:Middle Aged; D009780:Occult Blood; D010349:Patient Compliance; D010865:Pilot Projects; D012737:Sex Factors