gamma-Tocopherol: an efficient protector of lipids against nitric oxide-initiated peroxidative damage.
Nitric oxide released by macrophages during inflammation reacts with active oxygen to form peroxynitrite. Peroxynitrite nitrates protein and peroxidizes lipids. gamma-Tocopherol traps peroxynitrite and is more effective than alpha-tocopherol in protecting lipids against such peroxidation.
Wolf
G
G
Department of Nutritional Sciences, University of California, Berkeley 94720, USA.
D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects*; D008264:Macrophages / Q000378:metabolism; D009566:Nitrates / Q000737:chemistry / Q000494:pharmacology; D009569:Nitric Oxide / Q000494:pharmacology*; D014810:Vitamin E / Q000494:pharmacology*
D009566:Nitrates; D014810:Vitamin E; C039642:peroxynitric acid; D009569:Nitric Oxide