Chromosomal abnormalities in low grade chondrosarcoma and a review of the literature.
In this study, cytogenetic analysis of two low-grade chondrosarcomas revealed relatively simple chromosomal complements with structural rearrangements involving chromosomes 1, 6, and 12 [46,XY,add(16)(q24)[3]/46,XY,t(1;20)(q21;q11),t(6;17)(q23;q23)[3]/46,XY, t(4;14)(q12;q24),t(5;6)(q12;p21) [2] and 45,XY,t(12;16)(q13;q24),-14[17]/44,idem,add(4)(p16),-17,[2] respectively]. Previously published reports of chondrosarcoma have revealed structural abnormalities of chromosomes 1, 6, 9, 12, and 15 as common. Also, a correlation between the simplicity or complexity of the abnormalities seen and histologic grade has been suggested. The findings of the current study support these earlier observations.
Swarts
S J
SJ
Department of Orthopaedic Surgery, University of Nebraska Medical Center, Omaha 68198-5440, USA.
Neff
J R
JR
Nelson
M
M
Johansson
S
S
Bridge
J A
JA
D002813:Chondrosarcoma / Q000235:genetics* / Q000473:pathology; D006801:Humans; D007621:Karyotyping; D008297:Male; D008875:Middle Aged; D014178:Translocation, Genetic