title: Inappropriate shocks in patients receiving internal cardioverter-defibrillators for malignant ventricular arrhythmias.
abstract: Implantation of internal cardioverter defibrillators (ICDs) for treatment of malignant ventricular arrhythmias is complicated by failure of therapy or inappropriate shocks. We studied 81 patients (age range 16-72 years; mean 48 +/- 13 years) who underwent ICD implantation for device therapy. The underlying aetiology was ischaemic heart disease (39%), cardiomyopathies (32%) and others (28%). Information regarding shocks was collected using Holter monitoring, telemetry or device memory (stored electrograms) and lastly by clinical follow-up. Fifty-eight patients completed 36 months of follow-up. Thirty-five patients experienced 337 spontaneous shocks, appropriate in 21, inappropriate in 12, and both in two patients. Of the 74 episodes of inappropriate discharges for rhythms other that ventricular tachycardia (VT) or ventricular fibrillation(VF), 55 percent were due to supraventricular arrhythmias (atrial flutter or fibrillation). Lead malfunction occurred in four and the device was replaced in two. Additional drugs controlled AF in one. There was no mortality in any of the 81 patients. The frequency of shocks was highest in the first six months after implantation and atrial fibrillation remains the main cause. In conclusion, inappropriate shocks are frequent in patients undergoing ICD implantation.
authors.affiliation: Department of Cardiological Sciences, St. George's Hospital Medical School, London.
authors.forename: K
authors.initials: K
authors.lastname: Prasad
authors.forename: A G
authors.initials: AG
authors.lastname: Kishore
authors.forename: M H
authors.initials: MH
authors.lastname: Anderson
authors.forename: D E
authors.initials: DE
authors.lastname: Ward
authors.forename: E
authors.initials: E
authors.lastname: Rowland
authors.forename: J S
authors.initials: JS
authors.lastname: Gill
authors.forename: A J
authors.initials: AJ
authors.lastname: Camm
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D016009:Chi-Square Distribution; D017147:Defibrillators, Implantable / Q000009:adverse effects*; D004554:Electric Countershock; D015716:Electrocardiography, Ambulatory; D004868:Equipment Failure; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D014693:Ventricular Fibrillation / Q000628:therapy*