title: Organic surface chemistry on titanium surfaces via thin film deposition.
abstract: In order to develop a synthetic strategy for the fine tuning of the interfacial properties of titanium-based implants and implant parts, a thin polymeric film was deposited from ethylene plasma on the surfaces of Ti foils. The intended aim was to further modify the adherent, delamination-resistant organic coating using the techniques of surface modification of polymers to direct interfacial interactions at the metal foil-biological phase interface. In particular, air-plasma treatment and Ce(IV)-induced hydroxyethylmethacrylate grafting, two typical reactions of biomedical polymers surface chemistry, were used to improve cell adhesion or to impart cell resistance to the plasma-coated Ti. Results indicate that a plasma-deposited thin polymeric film effectively can act as a viable substrate for further surface chemical modifications and allow the application of a huge background of surface-modification polymers to metallic devices.
authors.affiliation: Nobil Bio Richerche, Villafranca d'Asti, Italy. mmorra@mbox.vol.it
authors.forename: M
authors.initials: M
authors.lastname: Morra
authors.forename: C
authors.initials: C
authors.lastname: Cassinelli
mesh_terms: D000818:Animals; D002448:Cell Adhesion; D002455:Cell Division; D002460:Cell Line; D002625:Chemistry, Organic; D005347:Fibroblasts / Q000166:cytology; D051379:Mice; D055601:Organic Chemistry Phenomena; D013499:Surface Properties; D014025:Titanium / Q000737:chemistry*
chemical_list: D014025:Titanium