CEA adhesion molecules: multifunctional proteins with signal-regulatory properties.
The carcinoembryonic antigen family comprises a large number of complex molecules, several of which possess cell adhesion activities. The primordial adhesion molecules of this family are the cell-cell adhesion molecules (C-CAMs), which have been found to be multifunctional, signal-regulatory proteins. C-CAMs inhibit tumor growth, interact with calmodulin, protein tyrosine kinases and protein tyrosine phosphatases, and are subject to specific dimerization reactions. These new insights indicate that C-CAMs are important regulators of cellular functions.
Obrink
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Department of Cell and Molecular Biology, Medical Nobel Institute, Karolinska Institute, Stockholm, Sweden. bjorn.obrink@cmb.ki.se
D000595:Amino Acid Sequence; D000818:Animals; D002272:Carcinoembryonic Antigen / Q000502:physiology*; D015815:Cell Adhesion Molecules / Q000502:physiology*; D006801:Humans; D008969:Molecular Sequence Data; D015398:Signal Transduction / Q000502:physiology*
D002272:Carcinoembryonic Antigen; D015815:Cell Adhesion Molecules