title: The successful use of protein C concentrate during pregnancy in a patient with type 1 protein C deficiency, previous thrombosis and recurrent fetal loss.
abstract: The risks of venous thrombosis and fetal loss are increased in patients with protein C deficiency. We describe a patient with a history of thrombosis and recurrent fetal loss who was found to have type 1 protein C deficiency. In view of her history and intolerance of heparin preparations, she was treated with protein C concentrate during the first and third trimesters of her seventh pregnancy. The patient suffered no thromboembolic event during this pregnancy and gave birth to a healthy infant. The implications of the success of this therapeutic strategy are discussed.
authors.affiliation: Department of Haematology, Royal Hallamshire Hospital, Sheffield.
authors.forename: E M
authors.initials: EM
authors.lastname: Richards
authors.forename: M
authors.initials: M
authors.lastname: Makris
authors.forename: F E
authors.initials: FE
authors.lastname: Preston
mesh_terms: D000026:Abortion, Habitual / Q000517:prevention & control*; D000328:Adult; D005260:Female; D006801:Humans; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000517:prevention & control*; D011250:Pregnancy Complications, Hematologic / Q000517:prevention & control*; D011261:Pregnancy Trimester, First; D011263:Pregnancy Trimester, Third; D011486:Protein C / Q000627:therapeutic use; D020151:Protein C Deficiency; D013923:Thromboembolism / Q000517:prevention & control*
chemical_list: D011486:Protein C