Effect of sodium chloride, chlorite, and perchlorate on the hypochlorite-induced peroxidation of phospholipid liposomes.
The abilities of sodium hypochlorite (NaClO), chlorite (NaClO2), chlorate (NaClO3), and perchlorate (NaClO4) to initiate lipid peroxidation (LP) in liposomes formed from unsaturated phosphatidylcholine were compared. It was shown that only NaClO induced an intensive accumulation of LP products (thiobarbituric acid-reactive substances and diene conjugates) in the liposomes as a result of their co-incubation. The other oxochlorates produced no similar effects and did not affect the hypochlorite-induced LP. This indicates that the observed hypochlorite-induced LP does not result from the presence of chlorite, chlorate, or perchlorate anion admixtures in the medium.
Panasenko
O M
OM
Research Institute of Physico-Chemical Medicine, Russia.
Arnhold
J
J
Sergienko
V I
VI
D000818:Animals; D002645:Chickens; D002712:Chlorides / Q000494:pharmacology*; D006997:Hypochlorous Acid / Q000494:pharmacology*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008081:Liposomes; D010472:Perchlorates / Q000494:pharmacology*; D010743:Phospholipids / Q000378:metabolism*; D012965:Sodium Chloride / Q000494:pharmacology*; D017670:Sodium Compounds / Q000494:pharmacology*; D013053:Spectrophotometry; D017392:Thiobarbituric Acid Reactive Substances / Q000032:analysis / Q000378:metabolism
D002712:Chlorides; D008081:Liposomes; D010472:Perchlorates; D010743:Phospholipids; D017670:Sodium Compounds; D017392:Thiobarbituric Acid Reactive Substances; D012965:Sodium Chloride; D006997:Hypochlorous Acid; C031068:sodium perchlorate; C001599:chlorite